US3842836A - Multi-mix - Google Patents
Multi-mix Download PDFInfo
- Publication number
- US3842836A US3842836A US33118773A US3842836A US 3842836 A US3842836 A US 3842836A US 33118773 A US33118773 A US 33118773A US 3842836 A US3842836 A US 3842836A
- Authority
- US
- United States
- Prior art keywords
- stopper
- compartment
- vial
- diaphragm
- hole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2093—Containers having several compartments for products to be mixed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/02—Internal fittings
- B65D25/04—Partitions
- B65D25/08—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents
- B65D25/082—Partitions with provisions for removing or destroying, e.g. to facilitate mixing of contents the partition being in the form of a plug or the like which is removed by increasing or decreasing the pressure within the container
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/202—Separating means
- A61J1/2041—Separating means having removable plugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/162—Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube
- A61M2005/1623—Details of air intake
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S215/00—Bottles and jars
- Y10S215/08—Mixing
Definitions
- ABSTRACT This patent describes a novel medicament container comprising a vial having an open end and a closed end, at least one slidable resilient stopper within the vial normally positioned intermediate the open end and the closed end and normally forming a fluid tight seal on the walls of the container, the stopper being slidable within said container away from the open end toward the closed end, the vial having a zone of a diameter larger then the largest lateral diameter of the stopper and into which the stopper is received as it is slid away from the open end to permit fluid communication from one side of the stopper to the other side of the stopper and thereby permit mixing of different materials positioned above and below the stopper, the container also having a closure at the open end to provide a multi-compartment medicament storage device.
- U.S. Pat. No. 2,717,601 discloses a syringe ampule having a tubular body, the bore of the body at a zone intermediate the ends being oval or elliptical in cross-section to provide recessed portions and thereby create a bypass for liquid normally confined within the bore and to the rear of a resilient stopper as the stopper is shifted laterally of the bore in the zone of the oval cross-section.
- This device is, at least theoretically, capable of providing a two-compartment device in which a solid medicament and a liquid medicament or diluent are separated prior to the time of administration.
- the present invention comprises a novel medicament container comprising a vial having an open end and a closed end, at least one slidable resilient stopper within said vial normally positioned intermediate said open end and saidclosed end and normally said bottom portion and integrally joined thereto by a step-like transition zone, and a top cylindrical portion having an internal diameter less than that of said intermediate portion and integrally joined thereto by a step like transition zone, said top portion having an open end, resilient slidable stoppers positioned in said top and intermediate portions immediately above said transition zones and forming fluid tight seals on the walls of said portions, said stopper having a lateral diameter less than the internal diameter of the cylindrical portion of the vial immediately below it, and a third slidable resilient stopper in said open end whereby when said third stopper is slid downwardly into said top portion, said other stoppers are dislod
- Another object of the present invention is the provision of a two-compartment medicament container in which the center plug is dislodged into an enlarged zone where the center plug can fall free and thereby be rendered incapable of becoming re-seated or otherwise interferring with adequate mixing of the various medicament components within the device.
- a further object of the present invention is to provide a multi-compartment medicament device in which the center plug is a lyophilizing plug.
- Still another object of the present invention is the provision of a three-compartment medicament conforming a fluid tight seal on the walls of said container,
- said stopper being slidable within said container away from said open end toward said closed end, said vial having a zone of a diameter larger than the largest lateral diameter of said stopper and into which said stopper is received as it is slid away from said open end to permit fluid communication from one side of said stopper to the other side of said stopper and thereby permit mixing of different materials positioned above and below said stopper, said container also having closure means at said open end to provide a multicompartment medicament storage device.
- This patent also describes a three-compartment medicament container comprising a vial having a bottom cylindrical portion having a closed end, an intermediate cylindrical portion having an internal diameter less than that of taining device adapted to mix two liquids and a powder or two powders and a liquid.
- FIG. 1 is a sectional view of one embodiment of the present invention as it appears during normal storage with a dry medicament in the lower portion and a diluent therefor in the upper portion.
- FIG. 2 shows the device of FIG. 1 in operation with the center plug dislodged into the enlarged center section.
- FIG. 3 is another embodiment of the present invention in which the lower portion is enlarged throughout its length as compared to the upper portion of the container.
- FIG. 4 shows still another embodiment of the present invention in which the upper normally open end of a container is provided with an accordian-like device adapted to create hydraulic pressure within the container and dislodge the center plug. This device is also equipped with an outlet for the discharge of the mixed medicament ingredients.
- FIG. 5 shows still another embodiment of the present invention in which two liquid materials and a solid are normally separated and yet are adapted to be mixed.
- FIG. 6 is similar to FIG. 5 except that the device contains two solid materials and one liquid material.
- FIG. 7 shows another and preferred embodiment of the present invention in which the center plug is provided with passages around its periphery to permit lyophilization of the dry powder at the bottom of the container after said center plug has been partially inserted but not seated in the container.
- FIG. 8 shows the device of FIG. 7 after lyophilization has been completed and the center plug has been fully seated on the restricting ring.
- FIG. 10 shows the device of FIGS. 7-9 in operation in which the second plug has been reciprocated longitudinally to dislodge the center plug and permit mixing.
- FIG. 11 is an enlarged end view of the center plug shown in FIGS. 7-10.
- FIG. 12 is a sectional view taken along the line l2-12 in FIG. 11.
- FIG. 14 shows the device of FIGS. 7-13 wherein the center plug is seated in a different manner.
- FIG. 15 shows another embodiment of the invention wherein the end plug is fixed or non-reciprocating.
- the container 10 has an enlarged center portion 12, a closed end 14, and an open end 16. Received in container 10 is center stopper 18 and a second or end stopper 20.
- the enlarged portion 12 is sufficiently larger in diameter than the zones above it and below it so that the center stopper 18 is essentially free of any sealing action when it is present in an enlarged zone. This result is provided by maintaining a greater inside diameter in portion 12 than the largest lateral diameter of stopper 18 over a longitudinal length of portion 12 which is at least slightly more than the longitudinal length of stopper 18.
- the container 22 has a lower portion 24 which is enlarged diametrically throughout its length as described above so that the center stopper 26 is free to fall therein when end stopper 28 is reciprocated in the upper part 30 of the container.
- FIG. 4 A variation of this device is shown in which the end of the container is provided with a bellows or accordion-like section 32 which when longitudinally compressed dislodges the center stopper 34 and permits mixing.
- the contents of the device can be discharged through tip 36 after removal of cover 38 secured to tip 36 by complementary threads 40.
- FIGS. 5 and 6 show a three-compartment device embodying the present invention.
- the top compartment 42 contains a liquid
- the intermediate compartment 44 contains a second liquid
- the bottom compartment 46 of the device contains a powder.
- the stoppers 48 and 50 are dislodgeable to permit mixing upon reciprocation of end stopper 52.
- this device may be used with two powders and a single diluent as shown in FIG. 6 or in any other combination of powders and liquids.
- FIGS. 7-13 involves the use of a lyophilizing stopper or plug 54.
- This plug 54 is provided with projections 56 around its lower periphery.
- the spaces 58 between the projections 56 provide a passage for any vapors coming from the inside of vial 60 during the lyophilizing process.
- the vial containing the material to be lyophilized is fitted with the plug in the position shown in FIG. 7.
- the vial is then placed in the lyophilizer and vacuum applied in conventional manner until the material within the vial has dried and the vapors withdrawn by passage through spaces 58.
- the operation at the time it is desired to administer the contents of the vial simply depresses the end stopper 66, as shown in FIG. 10 which dislodges the center lyophilizing plug 54 and permits mixing of the dry and wet materials.
- the contents of the vial can be removed using an ordinary hypodermic syringe provided with a needle which is used to puncture end stopper 66.
- the device of the present invention represents a major advance in the art of packaging wet-dry medication.
- the device is capable of simple fabrication.
- the vials used are normally glass and the .stoppers or plugs are usually formed of rubber or some other resilient material.
- a two compartment rigid mixing vial comprising a first compartment having a closed end, generally cylindrical walls, a second compartment having generally cylindrical walls, said first and second compartments having a common center line and being separated by an inwardly extending annular ring in the vial wall, a resilient imperforate first stopper in said second compartment, said first compartment being larger in diameter than said second compartment and said first stopper being receivable in said first compartment, a second resilient stopper sealing the end of said second compartment opposite said first stopper, said first stopper comprises an upper portion having one or more sealing rings forming a seal on the inside walls of said second compartment, and a lower portion comprising a series of generally vertical interruptions around the periphery of the lower portion, and an annular indentation immediately above said interruptions, said indentation being complementary in shape to said annular ring and receiving said ring to form a seal, said interruptions, when said sealing rings are held beyond the end of said sec- 0nd compartment by said interruptions, forming a force compression fit with the walls of said
- said second stopper contains a hole bridged by a diaphragm and a shallow dish-like depression surrounding said hole in that face of the stopper facing the inside of said second compartment whereby said hole acts as a collection point for the mixed material and substantially all of the contents of the vial can be removed therefrom when said diaphragm is pierced.
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
This patent describes a novel medicament container comprising a vial having an open end and a closed end, at least one slidable resilient stopper within the vial normally positioned intermediate the open end and the closed end and normally forming a fluid tight seal on the walls of the container, the stopper being slidable within said container away from the open end toward the closed end, the vial having a zone of a diameter larger then the largest lateral diameter of the stopper and into which the stopper is received as it is slid away from the open end to permit fluid communication from one side of the stopper to the other side of the stopper and thereby permit mixing of different materials positioned above and below the stopper, the container also having a closure at the open end to provide a multi-compartment medicament storage device.
Description
Elia
States atent [191 Ogle [ Oct. 22, 1974 1 MULTl-MIX Robert W. Ogle, Newport Beach, Calif.
Related US. Application Data [62] Division of Ser. No. 195,886, Nov. 4, 1971, which is a division of Ser. No. 830,311,,Iune 4,1969, Pat. No.
[75] Inventor:
[52] US. Cl 128/272, 206/47 A, 215/6, l28/D1G. 28 [51] int. Cl. A6lj l/00 [58] Fieldofsearch, l28/272,218M,2l6, DIG. 28; 206/47 A; 215/6, 38, 47, 56
[56] References Cited UNITED STATES PATENTS 2,305,278 12/1942 Smith l28/D1G. 28 2,649,090 8/1953 Parsons et a1 128/272 2,689,566 9/1954 Lockhart l28/D1G. 28 3,057,502 10/1962 Wood 215/47 3,144,151 8/1964 Grass l28/D1G. 28
3,330,280 7/1967 Ogle 128/218 M 3,330,282 7/1967 Visser et a1. 128/218 M 3,392,726 7/1968 Pochyla el al. 128/272 3,464,414 9/1969 Sponnoble l28/D1G. 28 3,467,097 9/1969 Ogle 128/272 3,552,387 1/1971 Stevens 128/272 Primary ExaminerRichard A. Gaudet Assistant Examiner-J. C. McGowan Attorney, Agent, or FirmJoseph E. Mueth 5 7] ABSTRACT This patent describes a novel medicament container comprising a vial having an open end and a closed end, at least one slidable resilient stopper within the vial normally positioned intermediate the open end and the closed end and normally forming a fluid tight seal on the walls of the container, the stopper being slidable within said container away from the open end toward the closed end, the vial having a zone of a diameter larger then the largest lateral diameter of the stopper and into which the stopper is received as it is slid away from the open end to permit fluid communication from one side of the stopper to the other side of the stopper and thereby permit mixing of different materials positioned above and below the stopper, the container also having a closure at the open end to provide a multi-compartment medicament storage device.
6 Claims, 15 Drawing Figures PAIfiNIEnumzzwu mama MULTI-MIX This application is a division of Ser. No. 195,886, filed Nov. 4, 1971, which in turn is a division Ser. No. 830,311, filed June 4, 1969, now U.S. Patent No. 3,674,028.
BACKGROUND OF THE INVENTION Brown U.S. Pat. No. 2,717,601 discloses a syringe ampule having a tubular body, the bore of the body at a zone intermediate the ends being oval or elliptical in cross-section to provide recessed portions and thereby create a bypass for liquid normally confined within the bore and to the rear of a resilient stopper as the stopper is shifted laterally of the bore in the zone of the oval cross-section. This device is, at least theoretically, capable of providing a two-compartment device in which a solid medicament and a liquid medicament or diluent are separated prior to the time of administration. However, in practice it has been found that the device of the above patent is essentially unacceptable because the oval cross-section is such that the minor diameter of the ellipse is approximately equal to the diameter of the stopper. Thus, when the stopper is moved, it still is maintained in the oval zone in an aligned position. The consequence of this is that when the operator applies force sufficient to laterally shift the center plug of the bore, which force is surprisingly great in most cases because of the seizure that the rings of the center plug take to the walls of the bore during storage, the center plug has sufficient inertia created by the force required to break the seizure that it traverses the zone of oval cross-section in an aligned state and comes to rest at the opposite end of the oval zone or beyond it thereby re-sealing the one compartment from the other. The consequence of this situation is that in many cases, the
Brown device fails as a mixing device for wet and dry medicament components. The present invention is believed to represent a substantial advance in the art in SUMMARY OF THE INVENTION Briefly, the present invention comprises a novel medicament container comprising a vial having an open end and a closed end, at least one slidable resilient stopper within said vial normally positioned intermediate said open end and saidclosed end and normally said bottom portion and integrally joined thereto by a step-like transition zone, and a top cylindrical portion having an internal diameter less than that of said intermediate portion and integrally joined thereto by a step like transition zone, said top portion having an open end, resilient slidable stoppers positioned in said top and intermediate portions immediately above said transition zones and forming fluid tight seals on the walls of said portions, said stopper having a lateral diameter less than the internal diameter of the cylindrical portion of the vial immediately below it, and a third slidable resilient stopper in said open end whereby when said third stopper is slid downwardly into said top portion, said other stoppers are dislodged from fluid tight sealing to permit communication between all three portions of said vial.
It is an object of the present invention to provide a novel multi-compartment medicament storage container.
Another object of the present invention is the provision of a two-compartment medicament container in which the center plug is dislodged into an enlarged zone where the center plug can fall free and thereby be rendered incapable of becoming re-seated or otherwise interferring with adequate mixing of the various medicament components within the device.
A further object of the present invention is to provide a multi-compartment medicament device in which the center plug is a lyophilizing plug.
Still another object of the present invention is the provision of a three-compartment medicament conforming a fluid tight seal on the walls of said container,
said stopper being slidable within said container away from said open end toward said closed end, said vial having a zone of a diameter larger than the largest lateral diameter of said stopper and into which said stopper is received as it is slid away from said open end to permit fluid communication from one side of said stopper to the other side of said stopper and thereby permit mixing of different materials positioned above and below said stopper, said container also having closure means at said open end to provide a multicompartment medicament storage device. This patent also describes a three-compartment medicament container comprising a vial having a bottom cylindrical portion having a closed end, an intermediate cylindrical portion having an internal diameter less than that of taining device adapted to mix two liquids and a powder or two powders and a liquid.
These and other objects and advantages of the present invention will be apparent from the more detailed description which follows taken in conjunction with the accompanying drawings.
DESCRIPTION OF PREFERRED EMBODIMENTS Turning to the drawings: FIG. 1 is a sectional view of one embodiment of the present invention as it appears during normal storage with a dry medicament in the lower portion and a diluent therefor in the upper portion.
FIG. 2 shows the device of FIG. 1 in operation with the center plug dislodged into the enlarged center section.
FIG. 3 is another embodiment of the present invention in which the lower portion is enlarged throughout its length as compared to the upper portion of the container.
FIG. 4 shows still another embodiment of the present invention in which the upper normally open end of a container is provided with an accordian-like device adapted to create hydraulic pressure within the container and dislodge the center plug. This device is also equipped with an outlet for the discharge of the mixed medicament ingredients.
FIG. 5 shows still another embodiment of the present invention in which two liquid materials and a solid are normally separated and yet are adapted to be mixed.
FIG. 6 is similar to FIG. 5 except that the device contains two solid materials and one liquid material.
FIG. 7 shows another and preferred embodiment of the present invention in which the center plug is provided with passages around its periphery to permit lyophilization of the dry powder at the bottom of the container after said center plug has been partially inserted but not seated in the container.
FIG. 8 shows the device of FIG. 7 after lyophilization has been completed and the center plug has been fully seated on the restricting ring.
FIG. 9 shows the completion of the device of FIG. 8 with the second plug fully inserted in place in the open end of the container.
FIG. 10 shows the device of FIGS. 7-9 in operation in which the second plug has been reciprocated longitudinally to dislodge the center plug and permit mixing.
FIG. 11 is an enlarged end view of the center plug shown in FIGS. 7-10.
FIG. 12 is a sectional view taken along the line l2-12 in FIG. 11.
FIG. 13 is a sectional view taken along the line l313 in FIG. 11.
FIG. 14 shows the device of FIGS. 7-13 wherein the center plug is seated in a different manner.
FIG. 15 shows another embodiment of the invention wherein the end plug is fixed or non-reciprocating.
Turning to the drawings in greater detail, as shown in FIG. 1 in one embodiment of the present invention the container 10 has an enlarged center portion 12, a closed end 14, and an open end 16. Received in container 10 is center stopper 18 and a second or end stopper 20. The enlarged portion 12 is sufficiently larger in diameter than the zones above it and below it so that the center stopper 18 is essentially free of any sealing action when it is present in an enlarged zone. This result is provided by maintaining a greater inside diameter in portion 12 than the largest lateral diameter of stopper 18 over a longitudinal length of portion 12 which is at least slightly more than the longitudinal length of stopper 18.
Turning to FIG. 3, the container 22 has a lower portion 24 which is enlarged diametrically throughout its length as described above so that the center stopper 26 is free to fall therein when end stopper 28 is reciprocated in the upper part 30 of the container. A variation of this device is shown in FIG. 4 in which the end of the container is provided with a bellows or accordion-like section 32 which when longitudinally compressed dislodges the center stopper 34 and permits mixing. The contents of the device can be discharged through tip 36 after removal of cover 38 secured to tip 36 by complementary threads 40.
FIGS. 5 and 6 show a three-compartment device embodying the present invention. In this device the top compartment 42 contains a liquid, the intermediate compartment 44 contains a second liquid and the bottom compartment 46 of the device contains a powder. The stoppers 48 and 50 are dislodgeable to permit mixing upon reciprocation of end stopper 52. Obviously, this device may be used with two powders and a single diluent as shown in FIG. 6 or in any other combination of powders and liquids.
The embodiment shown in FIGS. 7-13 involves the use of a lyophilizing stopper or plug 54. This plug 54 is provided with projections 56 around its lower periphery. The spaces 58 between the projections 56 provide a passage for any vapors coming from the inside of vial 60 during the lyophilizing process. In operation, the vial containing the material to be lyophilized is fitted with the plug in the position shown in FIG. 7. The vial is then placed in the lyophilizer and vacuum applied in conventional manner until the material within the vial has dried and the vapors withdrawn by passage through spaces 58. Then the plates which those skilled in the art will recognize are standard in a lyophilizer, are lowered forcing the plug 54 into the vial to an extent necessary for the sealing rings 62 to form a seal on the inner walls of the vial. Thereafter oxygen or air can be permitted to enter the lyophilizing chamber. The partial or complete atmospheric pressure on the exposed surface of the plug 54 will then force it down into the vial until it seats on restriction 64 in vial 60, as shown in FIGS. 8 and 9. In some cases, it is desirable after removal of the vial from the lyophilizer to manually or otherwise further advance the plug 54 within vial 60 so that the restriction 64 is positioned between rings 62. In any case, the diluent for the dry powder is then inserted into the upper portion of vial 60 as shown in FIGS. 8 and 9 and the second or end stopper 66 is inserted.
In operation of the completed vial, the operation at the time it is desired to administer the contents of the vial simply depresses the end stopper 66, as shown in FIG. 10 which dislodges the center lyophilizing plug 54 and permits mixing of the dry and wet materials. After mixing, the contents of the vial can be removed using an ordinary hypodermic syringe provided with a needle which is used to puncture end stopper 66.
In the embodiment of FIG. 15, the vial 68 is provided with a center plug 70 and a fixed end plug 72 having an annular flange 74. The center plug and vial can be of any of the configurations previously described. This device can be operated by inserting a probe through the thin diaphragm portion 76 of plug 72 to reach and dislodge plug 70 into the enlarged area, permitting mixing. The mixed contents can then be withdrawn by a variety of techniques including an ordinary hypodermic syringe.
Those skilled in the art will immediately recognize that the device of the present invention represents a major advance in the art of packaging wet-dry medication. The device is capable of simple fabrication. For example, the vials used are normally glass and the .stoppers or plugs are usually formed of rubber or some other resilient material.
Having fully described the invention it is intended that it be limited only by the lawful scope of the appended claims.
I claim:
1. A two compartment rigid mixing vial comprising a first compartment having a closed end, generally cylindrical walls, a second compartment having generally cylindrical walls, said first and second compartments having a common center line and being separated by an inwardly extending annular ring in the vial wall, a resilient imperforate first stopper in said second compartment, said first compartment being larger in diameter than said second compartment and said first stopper being receivable in said first compartment, a second resilient stopper sealing the end of said second compartment opposite said first stopper, said first stopper comprises an upper portion having one or more sealing rings forming a seal on the inside walls of said second compartment, and a lower portion comprising a series of generally vertical interruptions around the periphery of the lower portion, and an annular indentation immediately above said interruptions, said indentation being complementary in shape to said annular ring and receiving said ring to form a seal, said interruptions, when said sealing rings are held beyond the end of said sec- 0nd compartment by said interruptions, forming a force compression fit with the walls of said second compartment and the spaces between the interruptions being adapted to provide a gas passage from the interior of said first compartment to the exterior.
2. The vial of claim 1 wherein said second stopper has a diaphragm in that face of the stopper facing the inside of said second compartment through which a probe may be inserted to upset said first stopper.
3. The vial of claim 1 wherein said first compartment contains a powder and said second vial contains a liquid diluent for said powder.
4. The vial of claim 1 wherein said second stopper contains a hole bridged by a diaphragm in that face of the stopper facing the inside of said second compartment.
5. The vial of claim 1 wherein said second stopper contains a hole bridged by a diaphragm and a shallow dish-like depression surrounding said hole in that face of the stopper facing the inside of said second compartment whereby said hole acts as a collection point for the mixed material and substantially all of the contents of the vial can be removed therefrom when said diaphragm is pierced.
6. The vial of claim 1 wherein said second stopper contains a hole bridged by a diaphragm and a shallow dish-like depression surrounding said hole in that face of the stopper facing the inside of said second compartment whereby said hole acts as a collection point for the mixed material and substantially all of the contents of the vial can be removed therefrom when said diaphragm is pierced, said second stopper having an annular flange, the underside of which abuts the end of said via] to prevent movement of said second stopper into said second compartment.
Claims (6)
1. A two compartment rigid mixing vial comprising a first compartment having a closed end, generally cylindrical walls, a second compartment having generally cylindrical walls, said first and second compartments having a common center line and being separated by an inwardly extending annular ring in the vial wall, a resilient imperforate first stopper in said second compartment, said first compartment being larger in diameter than said second compartment and said first stopper being receivable in said first compartment, a second resilient stopper sealing the end of said second compartment opposite said first stopper, said first stopper comprises an upper portion having one or more sealing rings forming a seal on the inside walls of said second compartment, and a lower portion comprising a series of generally vertical interruptions around the periphery of the lower portion, and an annular indentation immediately above said interruptions, said indentation being complementary in shape to said annular ring and receiving said ring to form a seal, said interruptions, when said sealing rings are held beyond the end of said second compartment by said interruptions, forming a force compression fit with the walls of said second compartment and the spaces between the interruptions being adapted to provide a gas passage from the interior of said first compartment to the exterior.
2. The vial of claim 1 wherein said second stopper has a diaphragm in that face of the stopper facing the inside of said second compartment through which a probe may be inserted to upset said first stopper.
3. The vial of claim 1 wherein said first compartment contains a powder and said second vial contains a liquid diluent for said powder.
4. The vial of claim 1 wherein said second stopper contains a hole bridged by a diaphragm in that face of the stopper facing the inside of said second compartment.
5. The vial of claim 1 wherein said second stopper contains a hole bridged by a diaphragm and a shallow dish-like depression surrounding said hole in that face of the stopper facing the inside of said second compartment whereby said hole acts as a collection point for the mixed material and substantially all of the contents of the vial can be removed therefrom when said diaphragm is pierced.
6. The vial of claim 1 wherein said second stopper contains a hole bridged by a diaphragm and a shallow dish-like depression surrounding said hole in that face of the stopper facing the inside of said second compartment whereby said hole acts as a collection point for the mixed material and substantially all of the contents of the vial can be removed therefrom when said diaphragm is pierced, said second stopper having an annular flange, the underside of which abuts the end of said vial to prevent movement of said second stopper into said second compartment.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3674028D US3674028A (en) | 1969-06-04 | 1969-06-04 | Multi-mix |
CA082,308A CA958380A (en) | 1969-06-04 | 1970-05-08 | Multiple compartment container |
US33118773 US3842836A (en) | 1969-06-04 | 1973-02-09 | Multi-mix |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83031169A | 1969-06-04 | 1969-06-04 | |
US19588671A | 1971-11-04 | 1971-11-04 | |
US33118773 US3842836A (en) | 1969-06-04 | 1973-02-09 | Multi-mix |
Publications (1)
Publication Number | Publication Date |
---|---|
US3842836A true US3842836A (en) | 1974-10-22 |
Family
ID=39745493
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US3674028D Expired - Lifetime US3674028A (en) | 1969-06-04 | 1969-06-04 | Multi-mix |
US33118773 Expired - Lifetime US3842836A (en) | 1969-06-04 | 1973-02-09 | Multi-mix |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US3674028D Expired - Lifetime US3674028A (en) | 1969-06-04 | 1969-06-04 | Multi-mix |
Country Status (2)
Country | Link |
---|---|
US (2) | US3674028A (en) |
CA (1) | CA958380A (en) |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2318653A1 (en) * | 1975-07-24 | 1977-02-18 | Merck Patent Gmbh | TWO CHAMBERS INJECTOR |
US4113097A (en) * | 1976-08-09 | 1978-09-12 | Diagnostic Isotopes Incorporated | Ampule capable of being autoclaved |
EP0122514A2 (en) * | 1983-04-13 | 1984-10-24 | Eppendorf-Netheler-Hinz Gmbh | Device for delivering at least one concentrate to a solvent in at least one addition step, as well as with the control element |
US4591357A (en) * | 1985-09-27 | 1986-05-27 | Sneider Vincent R | Container for drug isolation, storage and subsequent mixing |
US4927013A (en) * | 1989-04-12 | 1990-05-22 | Eastman Kodak Company | Package for storing and remixing two materials |
FR2639914A1 (en) * | 1988-12-05 | 1990-06-08 | Corbiere Jerome | NEW DISPENSER DEVICE FOR LIQUID PREPARATIONS |
US4979941A (en) * | 1989-12-05 | 1990-12-25 | International Medication Systems, Limited | Device suitable for mixing medication |
FR2658487A1 (en) * | 1990-02-21 | 1991-08-23 | Valois | Device for spraying a medicine constituted by a mixture to be formed at the moment of emission |
WO1992004978A1 (en) * | 1990-09-26 | 1992-04-02 | Cryo-Cell International, Inc. | Method for use in preparing biological samples and related storage receptacle |
US5188803A (en) * | 1988-12-01 | 1993-02-23 | Abbott Laboratories | Device for preparing a medical sensor for use |
US5335773A (en) * | 1993-07-02 | 1994-08-09 | Habley Medical Technology Corporation | Multi-pharmaceutical storage, mixing and dispensing vial |
WO1995001285A1 (en) * | 1993-07-02 | 1995-01-12 | Habley Medical Technology Corporation | Multi-pharmaceutical storage, mixing and dispensing vial |
EP0803261A1 (en) * | 1995-08-09 | 1997-10-29 | HIGASHIKAWA, Tetsuro | Syringe, sealing construction and method therefor, and slide valve for syringe |
FR2767514A1 (en) * | 1997-08-22 | 1999-02-26 | Dominique Mounier | Container for mixing two part compounds just prior to injection by syringe |
WO1999015096A1 (en) * | 1997-09-22 | 1999-04-01 | Teva Pharmaceutical Industries Ltd. | Ampoules holding an injectable liquid |
WO1999024171A2 (en) * | 1997-11-08 | 1999-05-20 | Ing. Erich Pfeiffer Gmbh | Application method for at least two different media and dispenser therefor |
WO2000023037A1 (en) * | 1998-10-17 | 2000-04-27 | Boehringer Ingelheim Pharma Kg | Two chamber cartridge for atomizers |
US20050007870A1 (en) * | 2003-05-20 | 2005-01-13 | C.R.F. Societa Consortile Per Azioni | Disposable cartridge for mixing exothermic or endothermic reaction substances, and relative cartridge-support assembly |
US6905488B2 (en) | 1999-11-22 | 2005-06-14 | Kimberly-Clark Worldwide, Inc. | Absorbent article with child resistant refastenable seams |
US20070005027A1 (en) * | 2004-05-13 | 2007-01-04 | Talamonti Anthony R | Medical treatment kit and methods of use thereof |
US7213593B2 (en) | 1996-04-19 | 2007-05-08 | Boehringer Ingelheim Kg | Two-chamber cartridge for propellant-free metering aerosols |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10099022B2 (en) | 2014-05-07 | 2018-10-16 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3857392A (en) * | 1969-06-04 | 1974-12-31 | Ims Ltd | Intravenous container with dislodgeable septum and dislodging piercer |
US3941128A (en) * | 1970-11-10 | 1976-03-02 | Affiliated Hospital Products, Inc. | Fluid dispensing arrangement |
CH666870A5 (en) * | 1986-04-10 | 1988-08-31 | Cosmonor Sa | DEVICE FOR PACKAGING LIQUID OR LIQUID AND SOLID SUBSTANCES. |
CA2006582A1 (en) * | 1988-12-27 | 1990-06-27 | Gabriel Meyer | Storage and transfer bottle for storing two components of a medicinal substance |
CA2006584C (en) * | 1988-12-27 | 1998-11-10 | Gabriel Meyer | Storage and transfer bottle for storing a component of a medicinal substance |
GB8911878D0 (en) * | 1989-05-24 | 1989-07-12 | Allen Nicholas J | Mixing device |
WO1991007160A1 (en) * | 1989-11-13 | 1991-05-30 | Medicorp Holding S.A. | Storage bottle containing a constituent of a medicinal solution |
ATE125344T1 (en) * | 1990-08-30 | 1995-08-15 | Omniglow Corp | CHEMILUMINESCENT LIGHT ELEMENT. |
IT1251658B (en) * | 1991-10-07 | 1995-05-19 | Inge Spa | SINGLE USE DEVICE PREFERABLY FOR HYGIENE-SANITARY USE. |
US5353961A (en) * | 1993-01-15 | 1994-10-11 | Reseal International Limited Partnership | Dual chamber dispenser |
TW360548B (en) * | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
US5702019A (en) * | 1995-09-27 | 1997-12-30 | Becton Dickinson France S.A. | Vial having resealable membrane assembly activated by a medical delivery device |
US6003702A (en) * | 1995-09-27 | 1999-12-21 | Becton Dickinson France, S.A. | Vial with resealable connector assembly having a membrane and a multi-configuration fluid access device |
CA2185494A1 (en) | 1995-09-27 | 1997-03-28 | Jean-Pierre Grimard | Resealable vial with connector assembly having a membrane and pusher |
US5871110A (en) * | 1996-09-13 | 1999-02-16 | Grimard; Jean-Pierre | Transfer assembly for a medicament container having a splashless valve |
US5873872A (en) * | 1996-09-17 | 1999-02-23 | Becton Dickinson And Company | Multipositional resealable vial connector assembly for efficient transfer of liquid |
US6090093A (en) * | 1997-09-25 | 2000-07-18 | Becton Dickinson And Company | Connector assembly for a vial having a flexible collar |
US6213994B1 (en) | 1997-09-25 | 2001-04-10 | Becton Dickinson France, S.A. | Method and apparatus for fixing a connector assembly onto a vial |
US5925029A (en) * | 1997-09-25 | 1999-07-20 | Becton, Dickinson And Company | Method and apparatus for fixing a connector assembly onto a vial with a crimp cap |
US6003566A (en) * | 1998-02-26 | 1999-12-21 | Becton Dickinson And Company | Vial transferset and method |
US6382442B1 (en) | 1998-04-20 | 2002-05-07 | Becton Dickinson And Company | Plastic closure for vials and other medical containers |
US6681946B1 (en) * | 1998-02-26 | 2004-01-27 | Becton, Dickinson And Company | Resealable medical transfer set |
US6904662B2 (en) * | 1998-04-20 | 2005-06-14 | Becton, Dickinson And Company | Method of sealing a cartridge or other medical container with a plastic closure |
US6378714B1 (en) | 1998-04-20 | 2002-04-30 | Becton Dickinson And Company | Transferset for vials and other medical containers |
US6957745B2 (en) * | 1998-04-20 | 2005-10-25 | Becton, Dickinson And Company | Transfer set |
US6209738B1 (en) | 1998-04-20 | 2001-04-03 | Becton, Dickinson And Company | Transfer set for vials and medical containers |
DE19922285A1 (en) * | 1999-05-14 | 2000-11-16 | Febit Ferrarius Biotech Gmbh | Sample vessel used for handling liquids, powders and granules has two front ends with a casing between the ends to limit a sample vessel chamber |
GB0100756D0 (en) | 2001-01-11 | 2001-02-21 | Powderject Res Ltd | Needleless syringe |
US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
US7482116B2 (en) | 2002-06-07 | 2009-01-27 | Dna Genotek Inc. | Compositions and methods for obtaining nucleic acids from sputum |
DE10226887C1 (en) * | 2002-06-17 | 2003-12-24 | Schwan-Stabilo Cosmetics Gmbh | Sleeve for at least partially receiving an applicator for cosmetic products |
WO2004000678A1 (en) * | 2002-06-25 | 2003-12-31 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Mixing vial |
US7028869B2 (en) * | 2002-07-15 | 2006-04-18 | L'oreal S.A. | Device and method for packaging at least one product and method for mixing at least two products |
US8147426B2 (en) * | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
US20080135424A1 (en) * | 2006-12-08 | 2008-06-12 | Dan Ostrowski | Dispensing Tube For A Powdered Drink Mix |
GB0708758D0 (en) | 2007-05-04 | 2007-06-13 | Powderject Res Ltd | Particle cassettes and process thereof |
CA2839693A1 (en) | 2011-06-19 | 2012-12-27 | Abogen, Inc. | Devices, solutions and methods for sample collection |
US9522771B2 (en) * | 2015-04-30 | 2016-12-20 | Fang Lin Yang | Container for receiving two materials |
AU2019384801A1 (en) | 2018-11-20 | 2021-06-10 | Spectrum Solutions, Llc | Sample collection system including sealing cap and valve |
US11701094B2 (en) | 2019-06-20 | 2023-07-18 | Spectrum Solutions L.L.C. | Sample collection system including valve and plug assemblies |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2717601A (en) * | 1949-08-10 | 1955-09-13 | Frederick M Turnbull | Syringe ampule |
US2847996A (en) * | 1953-08-13 | 1958-08-19 | Miljam Instr Corp | Hypodermic syringe |
US2869745A (en) * | 1954-02-05 | 1959-01-20 | Compule Corp | Plunger closures of containers |
US3163163A (en) * | 1960-12-14 | 1964-12-29 | Upjohn Co | Admixing vial or container |
US3198194A (en) * | 1963-05-13 | 1965-08-03 | Upjohn Co | Admixing storage container with means preventing inadvertent removal of closure means |
-
1969
- 1969-06-04 US US3674028D patent/US3674028A/en not_active Expired - Lifetime
-
1970
- 1970-05-08 CA CA082,308A patent/CA958380A/en not_active Expired
-
1973
- 1973-02-09 US US33118773 patent/US3842836A/en not_active Expired - Lifetime
Cited By (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2318653A1 (en) * | 1975-07-24 | 1977-02-18 | Merck Patent Gmbh | TWO CHAMBERS INJECTOR |
US4113097A (en) * | 1976-08-09 | 1978-09-12 | Diagnostic Isotopes Incorporated | Ampule capable of being autoclaved |
EP0122514A2 (en) * | 1983-04-13 | 1984-10-24 | Eppendorf-Netheler-Hinz Gmbh | Device for delivering at least one concentrate to a solvent in at least one addition step, as well as with the control element |
EP0122514A3 (en) * | 1983-04-13 | 1986-01-22 | Eppendorf Geratebau Netheler + Hinz Gmbh | Device for delivering at least one concentrate to a solvent in at least one addition step, as well as with the control element |
US4591357A (en) * | 1985-09-27 | 1986-05-27 | Sneider Vincent R | Container for drug isolation, storage and subsequent mixing |
US5188803A (en) * | 1988-12-01 | 1993-02-23 | Abbott Laboratories | Device for preparing a medical sensor for use |
FR2639914A1 (en) * | 1988-12-05 | 1990-06-08 | Corbiere Jerome | NEW DISPENSER DEVICE FOR LIQUID PREPARATIONS |
EP0373016A1 (en) * | 1988-12-05 | 1990-06-13 | Jérôme CORBIERE | Dispensing device for liquids |
US5071034A (en) * | 1988-12-05 | 1991-12-10 | Jerome Corbiere | Distributing device for liquid preparations |
US4927013A (en) * | 1989-04-12 | 1990-05-22 | Eastman Kodak Company | Package for storing and remixing two materials |
US4979941A (en) * | 1989-12-05 | 1990-12-25 | International Medication Systems, Limited | Device suitable for mixing medication |
FR2658487A1 (en) * | 1990-02-21 | 1991-08-23 | Valois | Device for spraying a medicine constituted by a mixture to be formed at the moment of emission |
WO1992004978A1 (en) * | 1990-09-26 | 1992-04-02 | Cryo-Cell International, Inc. | Method for use in preparing biological samples and related storage receptacle |
US5335773A (en) * | 1993-07-02 | 1994-08-09 | Habley Medical Technology Corporation | Multi-pharmaceutical storage, mixing and dispensing vial |
WO1995001285A1 (en) * | 1993-07-02 | 1995-01-12 | Habley Medical Technology Corporation | Multi-pharmaceutical storage, mixing and dispensing vial |
US5593028A (en) * | 1993-07-02 | 1997-01-14 | Habley Medical Technology Corporation | Multi-pharmaceutical storage, mixing and dispensing vial |
EP0803261A1 (en) * | 1995-08-09 | 1997-10-29 | HIGASHIKAWA, Tetsuro | Syringe, sealing construction and method therefor, and slide valve for syringe |
EP0803261A4 (en) * | 1995-08-09 | 2000-03-01 | Tetsuro Higashikawa | Syringe, sealing construction and method therefor, and slide valve for syringe |
US7793655B2 (en) | 1996-04-19 | 2010-09-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Two-chamber cartridge for propellant-free metering aerosols |
US7213593B2 (en) | 1996-04-19 | 2007-05-08 | Boehringer Ingelheim Kg | Two-chamber cartridge for propellant-free metering aerosols |
US7980243B2 (en) | 1996-04-19 | 2011-07-19 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | Two-chamber cartridge for propellant-free metering aerosols |
WO1999010245A1 (en) * | 1997-08-22 | 1999-03-04 | Dominique Mounier | Mixing flask contacting two isolated constituents before they are drawn and injected into a syringe |
CN1071242C (en) * | 1997-08-22 | 2001-09-19 | 多米尼克·穆尼耶 | Mixing flask contacting two isolated constituents before they are drawn and injected into syringe |
FR2767514A1 (en) * | 1997-08-22 | 1999-02-26 | Dominique Mounier | Container for mixing two part compounds just prior to injection by syringe |
WO1999015096A1 (en) * | 1997-09-22 | 1999-04-01 | Teva Pharmaceutical Industries Ltd. | Ampoules holding an injectable liquid |
WO1999024171A2 (en) * | 1997-11-08 | 1999-05-20 | Ing. Erich Pfeiffer Gmbh | Application method for at least two different media and dispenser therefor |
WO1999024171A3 (en) * | 1997-11-08 | 1999-07-15 | Pfeiffer Erich Gmbh & Co Kg | Application method for at least two different media and dispenser therefor |
US6626379B1 (en) | 1997-11-08 | 2003-09-30 | Ing. Erich Pfeiffer Gmbh | Application method for at least two different media and dispenser therefor |
US20030066524A1 (en) * | 1998-10-17 | 2003-04-10 | Boehringer Ingelheim Pharma Kg | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage |
US6986346B2 (en) | 1998-10-17 | 2006-01-17 | Boehringer Ingelheim Pharma Kg | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage |
US20060196500A1 (en) * | 1998-10-17 | 2006-09-07 | Boehringer Ingelheim Pharma Kmbh & Co. Kg | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage |
HRP20010273B1 (en) * | 1998-10-17 | 2009-02-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Two chamber cartridge for atomizers |
WO2000023037A1 (en) * | 1998-10-17 | 2000-04-27 | Boehringer Ingelheim Pharma Kg | Two chamber cartridge for atomizers |
CZ300606B6 (en) * | 1998-10-17 | 2009-06-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg. | Device consisting of closure cap and container |
US6905488B2 (en) | 1999-11-22 | 2005-06-14 | Kimberly-Clark Worldwide, Inc. | Absorbent article with child resistant refastenable seams |
US7303328B2 (en) * | 2003-05-20 | 2007-12-04 | C.R.F. Societa Consortile Per Azioni | Disposable cartridge for mixing exothermic or endothermic reaction substances, and relative cartridge-support assembly |
US20050007870A1 (en) * | 2003-05-20 | 2005-01-13 | C.R.F. Societa Consortile Per Azioni | Disposable cartridge for mixing exothermic or endothermic reaction substances, and relative cartridge-support assembly |
US7789854B2 (en) * | 2004-05-13 | 2010-09-07 | Talamonti Anthony R | Medical treatment kit and methods of use thereof |
US20070005027A1 (en) * | 2004-05-13 | 2007-01-04 | Talamonti Anthony R | Medical treatment kit and methods of use thereof |
US20100197542A1 (en) * | 2004-05-13 | 2010-08-05 | Talamonti Anthony R | Medical Treatment Kit and Methods Of Use Thereof |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US10220163B2 (en) | 2012-04-13 | 2019-03-05 | Boehringer Ingelheim International Gmbh | Nebuliser with coding means |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10894134B2 (en) | 2013-08-09 | 2021-01-19 | Boehringer Ingelheim International Gmbh | Nebulizer |
US11642476B2 (en) | 2013-08-09 | 2023-05-09 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10716905B2 (en) | 2014-02-23 | 2020-07-21 | Boehringer Lngelheim International Gmbh | Container, nebulizer and use |
US10099022B2 (en) | 2014-05-07 | 2018-10-16 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
Also Published As
Publication number | Publication date |
---|---|
US3674028A (en) | 1972-07-04 |
CA958380A (en) | 1974-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3842836A (en) | Multi-mix | |
US4153057A (en) | Stopper for two-chamber mixing syringe | |
US3542023A (en) | Minimix | |
US4768568A (en) | Hazardous material vial apparatus providing expansible sealed and filter vented chambers | |
US4048999A (en) | Two-chamber mixing syringe | |
US3198194A (en) | Admixing storage container with means preventing inadvertent removal of closure means | |
US4994043A (en) | Two compartment syringe | |
US3330281A (en) | Combination syringe and vial mixing container | |
US4516967A (en) | Wet-dry compartmental syringe | |
US3788524A (en) | Additive container | |
US3810469A (en) | Multiple compartment hypodermic devices | |
US5752940A (en) | Syringe and method for lyophilizing and reconstituting injectable medication | |
US3858580A (en) | Intravenous container mixing assembly | |
US5060812A (en) | Medication container stopper which can be punctured by nozzle of a hypodermic syringe | |
US3340869A (en) | Collapsible ampoules | |
JP2801207B2 (en) | Syringe and method of assembling syringe | |
US4254768A (en) | Hypodermic syringe | |
US5489266A (en) | Syringe assembly and method for lyophilizing and reconstituting injectable medication | |
US3340873A (en) | Compartmented medical container having a rupturable diaphragm between compartments | |
US2591706A (en) | Plural-compartment admixing hypodermic syringe ampoule for segregated storage of ingredients of liquid medicinal solutions and therapeutic preparations | |
US3527215A (en) | Syringe construction having internal bladder | |
JPH024374A (en) | Liquid shifting assembly | |
US3467097A (en) | Dual medicinal vial | |
US3630199A (en) | Unitized injection system | |
US3416657A (en) | Syringe assembly unit |