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Bicuspid fascia lata valve

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US3739402A
US3739402A US3739402DA US3739402A US 3739402 A US3739402 A US 3739402A US 3739402D A US3739402D A US 3739402DA US 3739402 A US3739402 A US 3739402A
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Prior art keywords
ring
valve
tissue
base
struts
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P Kahn
D Cooley
D Liotta
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CUTTER LAB
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CUTTER LAB
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S623/00Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
    • Y10S623/90Stent for heart valve

Abstract

A graft-support for homograft and heterograft tissue valve implantation comprising a ring base, two struts extending from one side of the ring base and generally parallel to its axis, and a fabric layer covering the entire surface of the ring and struts. The fabric layer has a thickened portion at the apex of each strut, a second thickened portion along the top edge of the ring and a third thickened portion extending circumferentially of the ring. These thickened portions provide means for suturing the graft-support to the valve tissue and to the host heart, respectively. In one very advantageous embodiment, the ring is generally oblong in shape having a long diameter and a short diameter and the struts are disposed opposite to each other, one at each end of the oblong ring, i.e., at each end of the long diameter thereof or on a line parallel thereto. In effecting the transplantation, animal tissue, such as fascia lata derived from the patient, is wrapped around the upstanding struts and joined at the ends by suturing to form a closed ring of tissue, and forming also two cusps thereof supported by the struts. Each cusp is then sutured at its base to the covering at the top surface of the ring and along the sides of the struts, and a pledget of the fabric or suture is affixed around the top of the strut, the fabric thereover and the tissue to ensure coaptation of the cusps. The tissue, especially fascia lata from the patient, can also be extended to cover the side of the third thickened portion, or sewing ring, which is exposed to the ventricle so that, when the valve is emplaced, the entire ventricular surface is covered with autologous tissue. The device is then placed in the mitral valve position with struts extending into the ventricle and the host heart is sutured to the peripheral thickened flange, i.e., the third thickened portion.

Description

United States Patent 1 Cooley et al.

[ June 19, 1973 BICUSPID FASCIA LATA VALVE [73] Assignee: Cutter Laboratories, Inc., Berkeley,

Calif.

22 Filed: Oct. 15, 1970 21 Appl. No.: 81,064

OTHER PUBLICATIONS Surgery for Aortic Valve: Prosthesis and Heterograft by M. J. Levy et al., Surgery, Vol. 66, No. 2, pp. 313-318, August 1969.

-Surgitool Aortic Valve Prosthesis (Advertisement by Surgitool), The Journal of Thoracic & Cardiovascular Surgery, Vol. 58, No. 3, September 1969.

The Homograft Prosthesis by N. E. Shumway et al., Prosthetic Heart Valves by L. A. Brewer, Editor-in-- Chief, Charles C. Thomas, Publisher, Springfield, Illinois, pages 769-777, 1968.

Heart-Valve Replacement With 'Autologous Fascia Lata by M. l. Ionescoll et al., The Lancet, Vol. 2, Aug. 16, 1969, pages 335-338.

Technique of Mitral Valve Replacement with Autologous Fascia Lata by J. B. Flege et al., Journal of Thoracic & Cardiovascular Surgery, Vol. 54, No. 2, August 1967, pp. 222-226.

Prosthetic And Fascia Lata Valves: Hydrodynamics and Clinical Results by D. Liotta et al., Trans. Amer. Soc. Artif. lnt. Organs, Vol. XVI, April 1970, pages 244-251.

Primary ExaminerRichard A. Gaudet Assistant ExaminerRonald L. Frinks Attorney-Owen, Wickersham & Erickson and Bertram Bradley [57] ABSTRACT A graft-support for homograft and heterograft tissue valve implantation comprising a ring base, two struts extending from one side of the ring base and generally parallel to its axis, and a fabric layer covering the entire surface of the ring and struts. The fabric layer has a thickened portion at the apex of each strut, a second thickened portion along the top edge of the ring and a third thickened portion extending circumferentially of the ring. These thickened portions provide means for suturing the graft-support to the valve tissue and to the host heart, respectively. In one very advantageous embodiment, the ring is generally oblong in shape having a long diameter and a short diameter and the struts are disposed opposite to each other, one at each end of the oblong ring, i.e., at each end of the long diameter thereof or on a line parallel thereto.

In effecting the transplantation, animal tissue, such as fascia lata derived from the patient, is wrapped around the upstanding struts and joined at the ends by suturing to form a closed ring of tissue,and forming also two cusps thereof supported by the struts. Each cusp is then sutured at its baseto the covering at the top surface of the ring and along the sides of the struts, and a pledget of the fabric or suture is affixed around the top of the strut, the fabric thereover and the tissue to ensure coaptation of the cusps. The tissue, especially fascia lata from the patient, can also be extended to cover the side of the third thickened portion, or sewing ring, which is exposed to the ventricle so that, when the valve is emplaced, the entire ventricular surface is covered with autologous tissue. The device is then placed in the mitral valve position with struts extending into the ventricle and the host heart is sutured to the peripheral thickened flange, i.e., the third thickened portion.

12 Claims, 15 Drawing Figures PAIEMED 3.739.402

' sum 2 ur a INVENTOR. DENTON A COOLEY DOMINGO s. LIOTTA FIG, 1'] BYPAUL KAHN ATTORNEYS Pmmw 3739.402

SNEEI 3 If 3 INVENTOR. DENTON A. COOLEY DOMINGO s. LIOTTA PAUL KAHN ATTORNEYS BACKGROUND OF THE INVENTION This invention relates to a graft-support for valve transplantation into the human heart, and particularly it concerns a bicuspid device. The invention also concerns a method of effecting valve replacement, espe cially with the use of a homograft or autologous graft.

Synthesized and replacement tissue heart valves have been hitherto known to the art, and various types of such valves have been developed, both homograft and heterograft. It has been recognized that a tissue graft, e.g., using a semilunar valve as a replacement, is an advantageous means over a prosthesis because the dimensions of the natural valves are optimal and most nearly equal or approximate those of the damaged valve; after endothelialization no prosthetic material remains exposed to contact with the blood stream; and there is substantial absence of any thrombogenic surface or joint, so that the risk of complications from thrombosis and emboli is minimized. The longevity of aortic homograft valve has been well demonstrated and fresh aortic homografts have not appeared to deteriorate with time.

Homografts have also been used as mitral and tricuspid replacement valves. However, in addition to difficulty with supply, these have posed some problems also. Some have exhibited small but undesirable stagnant areas in the flow patterns. In others, the shape of the ring, generally circular, does not sufficiently closely approximate the shape of the damaged valve; and in these circular devices also the flow may be therefore somewhat restricted because of reduced diameter. Also, inasmuch as the homograft valve prostheses are mounted on a fabric covered frame at the time of surgery, it is desired to. perform this procedure in minimum time.

SUMMARY OF THE INVENTION The valve device of this invention attains the above objectives and has other advantages. Particularly, where it has an oblong ring base, it more closely approximates the shape of certain damaged valves to be replaced, i.e., in the mitral position or area. In other words, there is better anatomical conformation of the ring support to themitral annulus and of the two leaflets of the valve, to be more fully described below, in relation to the ventricular cavity than in the previously known tricuspid valve. It is a particular advantage of the bicuspid valve of this invention that two struts or prongs only extend into the ventricle, and the projection of a third prong intothe outflow track is avoided. It is a further advantage that, having a two-pronged ring provided as a base, and having a fabric cover, the fabrication of the completed, tissue-covered valve at surgery is a simpler and speedier procedure. The oblong base bicuspid valve of this invention also enables good flow of blood through a larger orifice and with lower pressure drop than is obtainable with circular base supports, since more of the mitral valve area can be occupied.

The stent or support frame of this invention comprises a rigid frame (made of metal or of rigid plastic such as Delrin, Teflon, or Nylon) including as a base a ring of plastic or metal resistant to the action of and compatible with body fluids, and such ring having two struts or prongs extending from the upper or the lower face thereof to enable formation of two cusps with later-added tissue. Preferably, the ring with struts is of metal and is machined from one piece of commercially pure titanium in order to avoid possible corrosion at metal interfaces and also to avoid casting faults in the metal. A layer of fabric is contoured to and completely covers all the surfaces of the metal base. The fabric is non-absorbent or resistant to and compatible with body fluids and is preferably knitted of yarn or fibers and sewn to conform tothe shape of the metal base frame. Tetrafluoroethylene (Teflon) fibers or yarn is especially suitable; but other suitable fabric, knitted or otherwise made, can be employed if desired. The fabric layer is provided with a first thickened portion at the apex of each strut, i.e., the end remote from the ring, a second thickened portion along the top edge of the frame, i.e., at the top of the ring and extending along the sides of the struts, and a third thickened portion, or sewing ring or flange, extending outwardly from the metal ring.

In the method of using the device of this invention, tissue, preferably autologous fascia lata, is wrapped around the support at the struts and the ends of the tissue strip are sutured together along the length of the strut. The tissue is also sutured to the second thickened portion along the top of the ring and at the sides of the struts thereby forming two leaflets of the valve. The tissue can also be extended over the sewing ring or flange and sutured thereto so that all prosthetic surfaces exposed to the ventricle are covered with homologus tissue. When emplaced in a heart, the two prongs of the stent extend from the valve seat into the ventricle at the sites of the anatomical commissures. The prongs simulate papillary muscles in reversed position, and extend only a short distance into the ventricle. The sewing ring is sutured to the annulus of the valve seat in the heart into which the valve replacement is being fitted. The operative lips of the tissue cusps or leaflets meet on a line parallel to the longitudinal center line of the base ring and can coincide with it or be offset from it.

The support ring can be used with autologous, homologous, and heterologous tissue, and, depending upon whether the ring base is oblong or circular, in any intracardiac position. It appears presently to be most advantageous when used with autologous tissue, such as a fascia lata graft taken from the patient.

BRIEF DESCRIPTION OF THE DRAWINGS The device of this invention, its method of use, and some of the objects and advantages of the invention will be illustrated by the specific description of one embodiment thereof which is set forth below, and by the annexed drawings wherein:

FIG. 1 is a plan view of a metal base or support ring according to the invention.

FIG. 2 is a side elevation view of the ring of FIG. 1.

FIG. 3 is an end view of the ring of FIGS. 1 and 2.

FIG. 4 is a perspective view of a graft-support according to the invention, comprising a metal base ring covered with knitted fabric.

FIG. 5 is a top plan view of the graft-support of FIG. 4.

FIG. 6 is a cross-sectional view through a typical fabri c-covered strut, taken on line 6-6 of FIG. 5.

FIG. 7 is a cross-sectional view through a fabriccoveredring, taken on line 77 of FIG. 5.

FIG. 8 is a side view showing a stent according to the invention in position to receive tissue and strip of tissue ready to be applied.

FIG. 9 is a top plan view of a valve replacement according to the invention showing juncture of cusps or valve leaflets.

FIG. 10 is a side view of the valve replacement of FIG. 9 showing suturing of leaflet at its base, to the underlying fabric of the ring support.

FIG. 1 1 is a perspective view of a bicuspid fascia lata valve according to this invention sutured into the mitral annulus of a heart.

FIGS. 12a, 12b, and 120 show schematically the relative shapes and relationships of the normal mitral valve, a prior art valve and the valve device of the present invention.

FIG. 13 is like FIG. 9 but shows an embodiment wherein the struts are displaced from the center line of the ring and provide one longer leaflet.

DETAILED DESCRIPTION OF THE INVENTION In one embodiment of the device of this invention, a graft-support ring base 10 is machined in one piece from commercially pure titanium, to eliminate any likelihood of corrosion at the metallic interfaces and the presence of casting faults. The ring 10 in this embodiment is generally oblong in form, having a long diameter and a short diameter, and it is provided with a pair of prongs or struts 11, 11' which are preferably disposed opposite each other at each end of the long diameter and both of which extend in the same direction from the ring base 12. The struts 11, 11' are rounded off at the top and connect with the ring base 12 at their sides through asmooth curve, thus avoiding sharp corners or abrupt turns, as shown in FIGS. 2, 3, 4, 8 and 10. A typical ring base is shown in FIGS. 1, 2, and 3. The struts extend generally perpendicularly to the plane of the ring base or can be outwardly inclined at a small angle to the perpendicular, e.g., of from 2 to 5 thereto, and each is provided with an aperture 13 near its apex. The ring base 12 is also provided with suitable apertures 27 whereby fabric cover 14 is sewn to and anchored to the ring base.

The ring base 12 is fitted with a fabric cover 14, as shown in FIGS. 4 to 8, to provide a suturing anchor and to which both the tissue and the host heart are sutured. This cover 14 is preferably a knitted fabric compatible with and resistant to attack by body fluids, for example, knitted Teflon (tetrafluoroethylene) fiber. In FIG. 4 is shown a typical knitted Teflon-covered device 15 comprising the ring base of FIGS. 1-3 and bearing the fabric cover 14. FIG. 6 shows a sectional view through a strut 11 having fabric cover 14 which is thickened at the top of strut 11 to provide a first thickened portion 16 to which later-applied tissue, especially fascia lata tissue, is sutured. As shown in FIG. 7, the fabric 14 is doubled over at the top of the base ring 12 to provide a second thickened portion 17 to which the cusps or leaflet bases of tissue as later applied are sutured. A third thickened portion 18 extends outwardly from ring base 12, suitably at an angle of from 30 to 60, preferably about 45, to the perpendicular or central axis of the ring, and provides a suturing anchor or support for fixing to the host heart when emplaced therein, as in the mitral valve position. If desired, the fabric of the sewing flange can be'partially quilted to stiffen it. Although the fabric has been described as being knitted Teflon, any other fabric, knitted, woven, felted or other can be employed which is compatible with the body flu ids and of sufficient strength.

When the base ring has been covered with the fabric cover, a rectangular piece of tissue 19, preferably autologous fascia lata, is wrapped around the prepared stent, as shown in FIGS. 8, 9 and 10 and is sutured at its ends to form a tube or a tubular tissue covering around the struts and intervening space. The tissue is sutured to the second thickened portion of fabric 14 to form two cusps or leaflets 20, 20 of the valve replacement and their upper edges 21, 21, i.e., those remote from the ring 12, lie adjacent each other to form the valve opening. The fascia lata tissue extends also over the sewing flange outer surface so that, when placed in the host heart all surfaces exposed to the ventricular cavity are of homologous tissue or of autologous tissue. A pledget of Teflon felt is wrapped around the apex of each strut, the fabric covering and the tissue thereover to ensure coaptation of the leaflets 21, 21', and is fixed in place by suturing. The valve replacement 25 is now ready for insertion into the host heart, after testing to determine that the leaflets operate properly. Such testing can be done by the method and means described in the co-pending patent application of Angel] et al. Ser. No. 726,288, filed May 3, 1968.

In the use and testing of the bicuspid valve of this invention, it has been found that the commissures during diastole separate approximately 2 millimeters, dropping the pressure gradient across the valve a little more than with prior art valve replacements and providing improved closure during systole. The anteromedial leaflet may be fabricated so that it is deeper than the lateral, thus becoming the principal leaflet during the functioning of the valve, such deeper leaflet being demonstrated in FIG. 13. In the embodiment of FIG. 13, struts 30, 30' are offset from the longitudinal center line of stent 31 and equidistant thereto, so that edges 21, 21' of leaflets 33, 33' are parallel to such center line. This has the result that one leaflet, 33, is longer or deeper than the other leaflet, 33, as described above.

FIG. 12a of the drawings shows a natural mitral valve 40 as occurring in a heart 41, having cusplets 42, 42', opening at 43. In FIG. 12b, the natural valve has been removed on line 44 and dotted line 45 indicates the shape of the circular base of the prior art, and lack of conformity can be seen. In FIG. 12c, the shape of the base 46 of the valve of the present invention can be seen to conform closely to the opening 44 in heart 41 which receives the valve replacement, cusplets 47, 47' meeting at line 48 to provide the valve opening during working of the valve.

The valve replacement 25 is inserted into the heart 41 to be treated, in a manner similar to that employed for the insertion of a prosthetic valve and to that described in the co-pending patent application of Angell et al, Ser. No. 726,288, filed May 3, 1968 and now U.S. Pat. No. 3,548,4l8. For mitral replacement No. 2-0 Tevdak sutures 35 are placed through the atrioventricular ring 36 of the patient, sixteen to twenty-two mattress sutures 35 being employed. When possible, the aorta is left unclamped and coronaries are perfused through the aortic root. If aortic cross-clamping is nec essary, local hypothermia may be employed for myocardial protection.

The sutures 35 are placed through the sewing ring 18 and valve replacement 25 is pushed gently into position being absolutely certain that struts 11, Ill slide past the atrioventricular ring 35 and lie in the ventricle. After assuring that sutures 35 are straight, they are pulled up and tied into place.

Caution is exercised in placement and orientation of valve replacement 25 in a small ventricle to prevent compromising the left ventricular outflow tract, and the device should be placed as high as possible in the mitral annulus consistent with good placement. Left ventricle and ascending aorta may be vented with a 20- gauge needle through the cardiac apex and ascending aorta.

All patients with prosthetic material exposed to he blood stream are preferably anticoagulated for 2-3 months postoperatively. With Coumadin (Warfarin sodium, Endo Laboratories, Inc.) as an anticoagulant, prothrombin times are maintained at 20 i 2 percent. Anticoagulants may be discontinued after a suitable period with the belief that the endothelialized surface will not form thrombus. Otherwise, patients can be treated as in any valve replacement, with gradually increasing activity.

The specific description and the drawings have been given for illustration only and modifications and variations can be made therein without departing from the spirit and scope of the appended claims. The ring base has been shown herein as oblong but it will be understood that a circular base ring can alternatively be used. The term oblong as used herein in the specification and claims is intended to mean a shape which is gener' ally oblong, that is, which has a long diameter and a short diameter, but wherein the corners and contours are rounded to conform more nearly to anatomical contours.

We claim: 1. A graft-support ring for a bicuspid valve for valve replacement in a damaged heart, including in combination a. a self-supporting shape-retaining frame comprising b. a rounded oblong ring having an upper face and a lower face and surrounding an oblong area having a major axis,

c. a pair of prongs extending from one of said faces and generally perpendicular to said oblong area, and being disposed on a plane parallel to said major axis and perpendicular to said area, and

d. a fabric covering compatible with body fluids contoured to said frame and completely enclosing it to provide a base for later suturing.

2. A graft-support ring as in claim 1 wherein said prongs extend from said ring approximately at the opposite ends of said major axis.

3. A graft-support ring as in claim 1 wherein said prongs are inclined outwardly at a small angle with respect to a line perpendicular to the plane of said area.

4. A graft-support ring for a bicuspid valve for use with autologous, homologous, or heterologous tissue, including in combination a. a self-supporting, shape-retaining frame comprisb. a generally oblong ring having an upper face, a

lower face, and a long diameter with a center,

c. a pair of struts extending from one of said faces and generally parallel to an axis through said cen' ter, and disposed on a plane parallel to said long diameter and perpendicular to the plane of said ring,

d. each said strut having an apex remote from said ring, and

e. a fabric covering compatible with body fluids con toured to said frame and completely enclosing it to provide a base for later suturing,

f. said covering having a first thickened portion adjacent each said apex, a second thickened portion along the surface of said ring to each said apex, and a third thickened portion extending outwardly from said ring to form a sewing flange.

5. A graft-support ring as in claim 4 wherein said metal ring and struts are machined from one piece of titanium metal.

6. A graft-support ring as in claim 4 wherein said flange extends at an angle of from about 30 to about 60 to said central axis.

7. A graft-support ring as in claim 4 wherein said struts are inclined outwardly at a small angle with respect to the axis of the ring.

8. A graft-support ring as in claim 4 wherein one of said struts is disposed on said metal ring at each end of said long diameter.

9. A bicuspid fascia lata valve for insertion into a ventricle valve opening of a heart and providing ventricleexposed surfaces, including in combination,

a. a self-supporting, shape-retaining frame comprisb. a generally oblong metal ring' having an upper face, a lower face, and a long diameter with a center,

c. a pair of prongs extending from one of said faces generally parallel to an axis through said center, and disposed on a plane parallel to said center, and perpendicular to the plane of said ring,

d. each of said prongs being disposed at each end of said plane and each said prong having an apex re mote from said ring,

e. a fabric covering compatible with body fluids contoured to and completely enclosing said frame to provide a base for suturing,

f. said covering having a first thickened portion at each said apex, a second thickened portion along said prongs and said face, and a third thickened portion extending as a sewing flange from said ring, and

g. fascia lata tissue covering said ventricle-exposed surfaces of said valve when inserted in said valve opening, and sutured to said fabric at said thickened portions.

10. A fascia lata valve as in claim 9 wherein said metal frame is machined from one piece of titanium.

11. A fascia lata valve as in claim 9 wherein said fascia lata is autologous tissue.

12. A fascia lata valve as in claim 9 wherein said struts are disposed on a plane parallel to and offset from said center line.

Claims (12)

1. A graft-support ring for a bicuspid valve for valve replacement in a damaged heart, including in combination a. a self-supporting shape-retaining frame comprising b. a rounded oblong ring having an upper face and a lower face and surrounding an oblong area having a major axis, c. a pair of prongs extending from one of said faces and generally perpendicular to said oblong area, and being disposed on a plane parallel to said major axis and perpendicular to said area, and d. a fabric covering compatible with body fluids contoured to said frame and completely enclosing it to provide a base for later suturing.
2. A graft-support ring as in claim 1 wherein said prongs extend from said ring approximately at the opposite ends of said major axis.
3. A graft-support ring as in claim 1 wherein said prongs are inclined outwardly at a small angle with respect to a line perpendicular to the plane of said area.
4. A graft-support ring for a bicuspid valve for use with autologous, homologous, or heterologous tissue, including in combination a. a self-supporting, shape-retaining frame comprising b. a generally oblong ring having an upper face, a lower face, and a long diameter with a center, c. a pair of struts extending from one of said faces and generally parallel to an axis through said center, and disposed on a plane parallel to said long diameter and perpendicular to the plane of said ring, d. each said strut having an apex remote from said ring, and e. a fabric covering compatible with body fluids contoured to said frame and completely enclosing it to provide a base for later suturing, f. said covering having a first thickened portion adjacent each said apex, a second thickened portion along the surface of said ring to each said apex, and a third thickened portion extending outwardly from said ring to form a sewing flange.
5. A graft-support ring as in claim 4 wherein said metal ring and struts are machined from one piece of titanium metal.
6. A graft-support ring as in claim 4 wherein said flange extends at an angle of from about 30* to about 60* to said central axis.
7. A graft-support ring as in claim 4 wherein said struts are inclined outwardly at a small angle with respect to the axis of the ring.
8. A graft-support ring as in claim 4 wherein one of said struts is disposed on said metal ring at each end of said long diameter.
9. A bicuspid fascia lata valve for insertion into a ventricle valve opening of a heart and providing ventricle-exposed surfaces, including in combination, a. a self-supporting, shape-retaining frame comprising b. a generally oblong metal ring having an upper face, a lower face, and a long diameter with a center, c. a pair of prongs extending from one of said faces generally parallel to an axis through said center, and disposed on a plane parallel to said center, and perpendicular to the plane of said ring, d. each of said prongs being disposed at each end of said plane and each said prong having an apex remote from said ring, e. a fabric covering compatible with body fluids contoured to and completely enclosing said frame to provide a base for suturing, f. said covering having a first thickened portion at each said apex, a second thickened portion along said prongs and said face, and a third thickened portion extending as a sewing flange from said ring, and g. fascia lata tissue covering said ventricle-exposed surfaces of said valve when inserted in said valve opening, and sutured to said fabric at said thickened portions.
10. A fascia lata valve as in claim 9 wherein said metal frame is machined from one piece of titanium.
11. A fascia lata valve as in claim 9 wherein said fascia lata is autologous tissue.
12. A fascia lata valve as in claim 9 wherein said struts are disposed on a plane parallel to and offset from said center line.
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Cited By (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078268A (en) * 1975-04-24 1978-03-14 St. Jude Medical, Inc. Heart valve prosthesis
US4275469A (en) * 1979-12-13 1981-06-30 Shelhigh Inc. Prosthetic heart valve
US4306319A (en) * 1980-06-16 1981-12-22 Robert L. Kaster Heart valve with non-circular body
US4339831A (en) * 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4340977A (en) * 1980-09-19 1982-07-27 Brownlee Richard T Catenary mitral valve replacement
US4343048A (en) * 1979-08-06 1982-08-10 Ross Donald N Stent for a cardiac valve
USRE31040E (en) * 1975-04-24 1982-09-28 St. Jude Medical, Inc. Heart valve prosthesis
US4366581A (en) * 1981-09-02 1983-01-04 Medical Incorporated Elliptical suturing cuff
US4372317A (en) * 1975-10-24 1983-02-08 Look International Enterprises, Inc. Method of installing a scalp anchor for a hairpiece
EP0084395A1 (en) * 1982-01-20 1983-07-27 Martin Morris Black Artificial heart valves
US4441216A (en) * 1980-11-03 1984-04-10 Shiley, Inc. Tissue heart valve and stent
EP0108941A2 (en) * 1982-10-14 1984-05-23 PRO.BIO.SPE. srl. A low-profile biological bicuspid valve
US4477930A (en) * 1982-09-28 1984-10-23 Mitral Medical International, Inc. Natural tissue heat valve and method of making same
EP0125393A1 (en) * 1980-11-03 1984-11-21 Shiley Incorporated Prosthetic heart valve
US4491986A (en) * 1976-05-12 1985-01-08 Shlomo Gabbay Heart valve
US4605407A (en) * 1983-01-11 1986-08-12 The University Of Sheffield Heart valve replacements
US4655773A (en) * 1984-09-21 1987-04-07 Ge. Sv. In. S.R.L. Bicuspid valve prosthesis for an auriculo-ventricular cardiac aperture
US4759759A (en) * 1983-06-23 1988-07-26 Walker David K Bubble heart valve
EP0276975A1 (en) * 1987-01-30 1988-08-03 Yoel Ovil Replacement of cardiac valves in heart surgery
US4851000A (en) * 1987-07-31 1989-07-25 Pacific Biomedical Holdings, Ltd. Bioprosthetic valve stent
WO1992019185A1 (en) * 1991-05-08 1992-11-12 Nika Health Products Limited Process and apparatus for the production of a heart valve prosthesis
US5503638A (en) * 1994-02-10 1996-04-02 Bio-Vascular, Inc. Soft tissue stapling buttress
US5554184A (en) * 1994-07-27 1996-09-10 Machiraju; Venkat R. Heart valve
US5769892A (en) * 1996-10-22 1998-06-23 Mitroflow International Inc. Surgical stapler sleeve for reinforcing staple lines
US5861028A (en) * 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
US6264691B1 (en) 1999-04-23 2001-07-24 Shlomo Gabbay Apparatus and method for supporting a heart valve
US6358277B1 (en) * 2000-06-21 2002-03-19 The International Heart Institute Of Montana Foundation Atrio-ventricular valvular device
US6582464B2 (en) * 2000-05-03 2003-06-24 Shlomo Gabbay Biomechanical heart valve prosthesis and method for making same
US20030163194A1 (en) * 2002-02-28 2003-08-28 Quijano Rodolfo C. Supportless atrioventricular heart valve and minimally invasive delivery systems thereof
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US20040078077A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffold for ligament or tendon repair
US20040092858A1 (en) * 2002-08-28 2004-05-13 Heart Leaflet Technologies, Inc. Leaflet valve
US6755857B2 (en) * 2001-12-12 2004-06-29 Sulzer Carbomedics Inc. Polymer heart valve with perforated stent and sewing cuff
WO2005004753A1 (en) * 2003-06-09 2005-01-20 3F Therapeutics, Inc. Atrioventricular heart valve and minimally invasive delivery systems thereof
US20050038520A1 (en) * 2003-08-11 2005-02-17 Francois Binette Method and apparatus for resurfacing an articular surface
US20050113937A1 (en) * 2003-11-26 2005-05-26 Francois Binette Conformable tissue repair implant capable of injection delivery
US20050125077A1 (en) * 2003-12-05 2005-06-09 Harmon Alexander M. Viable tissue repair implants and methods of use
US20050149181A1 (en) * 2004-01-07 2005-07-07 Medtronic, Inc. Bileaflet prosthetic valve and method of manufacture
US20050177249A1 (en) * 2004-02-09 2005-08-11 Kladakis Stephanie M. Scaffolds with viable tissue
WO2005072654A1 (en) * 2004-01-23 2005-08-11 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US20050187618A1 (en) * 2004-02-19 2005-08-25 Shlomo Gabbay Low profile heart valve prosthesis
WO2005087140A1 (en) * 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US20050232967A1 (en) 2004-04-20 2005-10-20 Kladakis Stephanie M Nonwoven tissue scaffold
US20070031470A1 (en) * 2004-04-20 2007-02-08 Depuy Mitek, Inc. Nonwoven tissue scaffold
US20070067029A1 (en) * 2005-09-16 2007-03-22 Shlomo Gabbay Support apparatus to facilitate implantation of cardiac prosthesis
US20070093890A1 (en) * 2005-10-26 2007-04-26 Eliasen Kenneth A Heart valve implant
US20070255399A1 (en) * 2005-10-26 2007-11-01 Eliasen Kenneth A Balloon Mitral Spacer
US20070265700A1 (en) * 2005-10-26 2007-11-15 Eliasen Kenneth A Safety for Mitral Valve Plug
US20080288061A1 (en) * 2007-05-14 2008-11-20 Maurer Christopher W Solid Construct Mitral Spacer
US20090043382A1 (en) * 2005-10-26 2009-02-12 Cardiosolutions, Inc. Mitral Spacer
US20090048668A1 (en) * 2008-06-13 2009-02-19 Cardiosolutions, Inc. System and Method for Implanting a Heart Implant
US20090132033A1 (en) * 2007-11-15 2009-05-21 Cardiosolutions, Inc. Implant Delivery System and Method
US20090131849A1 (en) * 2007-11-15 2009-05-21 Cardiosolutions, Inc. Heart regurgitation method and apparatus
US20090240326A1 (en) * 2005-10-26 2009-09-24 Cardiosolutions Implant Delivery and Deployment System and Method
US20100022948A1 (en) * 2008-06-13 2010-01-28 Cardiosolutions Steerable Catheter and Dilator and System and Method for Implanting a Heart Implant
US8016867B2 (en) 1999-07-23 2011-09-13 Depuy Mitek, Inc. Graft fixation device and method
US20120143324A1 (en) * 2010-09-30 2012-06-07 BioStable Science & Engineering, Inc. Aortic Valve Devices
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US8449561B2 (en) 1999-07-23 2013-05-28 Depuy Mitek, Llc Graft fixation device combination
US8691259B2 (en) 2000-12-21 2014-04-08 Depuy Mitek, Llc Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US20140155990A1 (en) * 2012-05-30 2014-06-05 Neovasc Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US8895045B2 (en) 2003-03-07 2014-11-25 Depuy Mitek, Llc Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
WO2014201384A1 (en) * 2013-06-14 2014-12-18 The Regents Of The University Of California Transcatheter mitral valve
US9161835B2 (en) 2010-09-30 2015-10-20 BioStable Science & Engineering, Inc. Non-axisymmetric aortic valve devices
US9232998B2 (en) 2013-03-15 2016-01-12 Cardiosolutions Inc. Trans-apical implant systems, implants and methods
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US20160143730A1 (en) * 2013-06-14 2016-05-26 Arash Kheradvar Transcatheter mitral valve
US9364354B2 (en) 2000-03-27 2016-06-14 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
WO2016114928A1 (en) * 2015-01-13 2016-07-21 Horizon Scientific Corp. Mitral bileaflet valve
US9433514B2 (en) 2005-11-10 2016-09-06 Edwards Lifesciences Cardiaq Llc Method of securing a prosthesis
US9456896B2 (en) 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9480560B2 (en) 2009-09-29 2016-11-01 Edwards Lifesciences Cardiaq Llc Method of securing an intralumenal frame assembly
US9539091B2 (en) 2001-09-13 2017-01-10 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US9545305B2 (en) 2013-06-14 2017-01-17 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9744059B2 (en) 2003-11-19 2017-08-29 Neovasc Medical Ltd. Vascular implant
US9844434B2 (en) 2006-10-06 2017-12-19 BioStable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3263239A (en) * 1963-04-01 1966-08-02 Edwards Lab Inc Aorta valve with expansible suturing ring
US3451067A (en) * 1966-06-16 1969-06-24 Daniel Lazo Jordan Heart valve
US3548418A (en) * 1968-05-03 1970-12-22 Cutter Lab Graft valve transplantation for human hearts and graft-support ring therefor
US3570014A (en) * 1968-09-16 1971-03-16 Warren D Hancock Stent for heart valve

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3263239A (en) * 1963-04-01 1966-08-02 Edwards Lab Inc Aorta valve with expansible suturing ring
US3451067A (en) * 1966-06-16 1969-06-24 Daniel Lazo Jordan Heart valve
US3548418A (en) * 1968-05-03 1970-12-22 Cutter Lab Graft valve transplantation for human hearts and graft-support ring therefor
US3570014A (en) * 1968-09-16 1971-03-16 Warren D Hancock Stent for heart valve

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Heart Valve Replacement With Autologous Fascia Lata by M. I. Ionescoll et al., The Lancet, Vol. 2, Aug. 16, 1969, pages 335 338. *
Prosthetic And Fascia Lata Valves: Hydrodynamics and Clinical Results by D. Liotta et al., Trans. Amer. Soc. Artif. Int. Organs, Vol. XVI, April 1970, pages 244 251. *
Surgery for Aortic Valve: Prosthesis and Heterograft by M. J. Levy et al., Surgery, Vol. 66, No. 2, pp. 313 318, August 1969. *
Surgitool Aortic Valve Prosthesis (Advertisement by Surgitool), The Journal of Thoracic & Cardiovascular Surgery, Vol. 58, No. 3, September 1969. *
Technique of Mitral Valve Replacement with Autologous Fascia Lata by J. B. Flege et al., Journal of Thoracic & Cardiovascular Surgery, Vol. 54, No. 2, August 1967, pp. 222 226. *
The Homograft Prosthesis by N. E. Shumway et al., Prosthetic Heart Valves by L. A. Brewer, Editor in Chief, Charles C. Thomas, Publisher, Springfield, Illinois, pages 769 777, 1968. *

Cited By (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4078268A (en) * 1975-04-24 1978-03-14 St. Jude Medical, Inc. Heart valve prosthesis
USRE31040E (en) * 1975-04-24 1982-09-28 St. Jude Medical, Inc. Heart valve prosthesis
US4372317A (en) * 1975-10-24 1983-02-08 Look International Enterprises, Inc. Method of installing a scalp anchor for a hairpiece
US4491986A (en) * 1976-05-12 1985-01-08 Shlomo Gabbay Heart valve
US4343048A (en) * 1979-08-06 1982-08-10 Ross Donald N Stent for a cardiac valve
US4275469A (en) * 1979-12-13 1981-06-30 Shelhigh Inc. Prosthetic heart valve
US4306319A (en) * 1980-06-16 1981-12-22 Robert L. Kaster Heart valve with non-circular body
US4340977A (en) * 1980-09-19 1982-07-27 Brownlee Richard T Catenary mitral valve replacement
EP0125393A1 (en) * 1980-11-03 1984-11-21 Shiley Incorporated Prosthetic heart valve
US4441216A (en) * 1980-11-03 1984-04-10 Shiley, Inc. Tissue heart valve and stent
US4339831A (en) * 1981-03-27 1982-07-20 Medtronic, Inc. Dynamic annulus heart valve and reconstruction ring
US4366581A (en) * 1981-09-02 1983-01-04 Medical Incorporated Elliptical suturing cuff
EP0084395A1 (en) * 1982-01-20 1983-07-27 Martin Morris Black Artificial heart valves
US4490859A (en) * 1982-01-20 1985-01-01 University Of Sheffield Artificial heart valves
US4477930A (en) * 1982-09-28 1984-10-23 Mitral Medical International, Inc. Natural tissue heat valve and method of making same
EP0108941B1 (en) * 1982-10-14 1989-07-12 PRO.BIO.SPE. srl. A low-profile biological bicuspid valve
US4561129A (en) * 1982-10-14 1985-12-31 Pro. Bio. Spe. S.R.L. Low-profile biological bicuspid valve
EP0108941A2 (en) * 1982-10-14 1984-05-23 PRO.BIO.SPE. srl. A low-profile biological bicuspid valve
US4605407A (en) * 1983-01-11 1986-08-12 The University Of Sheffield Heart valve replacements
US4759759A (en) * 1983-06-23 1988-07-26 Walker David K Bubble heart valve
US4655773A (en) * 1984-09-21 1987-04-07 Ge. Sv. In. S.R.L. Bicuspid valve prosthesis for an auriculo-ventricular cardiac aperture
EP0276975A1 (en) * 1987-01-30 1988-08-03 Yoel Ovil Replacement of cardiac valves in heart surgery
US4851000A (en) * 1987-07-31 1989-07-25 Pacific Biomedical Holdings, Ltd. Bioprosthetic valve stent
WO1992019185A1 (en) * 1991-05-08 1992-11-12 Nika Health Products Limited Process and apparatus for the production of a heart valve prosthesis
US5488789A (en) * 1991-05-08 1996-02-06 Nika Health Products Limited Process and apparatus for the production of a heart valve prosthesis
US5606928A (en) * 1991-05-08 1997-03-04 Nika Health Products Limited Process and apparatus for the production of a heart valve prosthesis
US5503638A (en) * 1994-02-10 1996-04-02 Bio-Vascular, Inc. Soft tissue stapling buttress
US5554184A (en) * 1994-07-27 1996-09-10 Machiraju; Venkat R. Heart valve
US5861028A (en) * 1996-09-09 1999-01-19 Shelhigh Inc Natural tissue heart valve and stent prosthesis and method for making the same
US5769892A (en) * 1996-10-22 1998-06-23 Mitroflow International Inc. Surgical stapler sleeve for reinforcing staple lines
US6264691B1 (en) 1999-04-23 2001-07-24 Shlomo Gabbay Apparatus and method for supporting a heart valve
US8449561B2 (en) 1999-07-23 2013-05-28 Depuy Mitek, Llc Graft fixation device combination
US8016867B2 (en) 1999-07-23 2011-09-13 Depuy Mitek, Inc. Graft fixation device and method
US9364354B2 (en) 2000-03-27 2016-06-14 Neovasc Medical Ltd Methods for treating abnormal growths in the body using a flow reducing implant
US6582464B2 (en) * 2000-05-03 2003-06-24 Shlomo Gabbay Biomechanical heart valve prosthesis and method for making same
US6610088B1 (en) * 2000-05-03 2003-08-26 Shlomo Gabbay Biologically covered heart valve prosthesis
US6358277B1 (en) * 2000-06-21 2002-03-19 The International Heart Institute Of Montana Foundation Atrio-ventricular valvular device
US8691259B2 (en) 2000-12-21 2014-04-08 Depuy Mitek, Llc Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US9572663B2 (en) 2001-09-13 2017-02-21 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US9572664B2 (en) 2001-09-13 2017-02-21 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US9539091B2 (en) 2001-09-13 2017-01-10 Edwards Lifesciences Corporation Methods and apparatuses for deploying minimally-invasive heart valves
US6755857B2 (en) * 2001-12-12 2004-06-29 Sulzer Carbomedics Inc. Polymer heart valve with perforated stent and sewing cuff
US20030163194A1 (en) * 2002-02-28 2003-08-28 Quijano Rodolfo C. Supportless atrioventricular heart valve and minimally invasive delivery systems thereof
US6974464B2 (en) 2002-02-28 2005-12-13 3F Therapeutics, Inc. Supportless atrioventricular heart valve and minimally invasive delivery systems thereof
US20040092858A1 (en) * 2002-08-28 2004-05-13 Heart Leaflet Technologies, Inc. Leaflet valve
US8163008B2 (en) 2002-08-28 2012-04-24 Heart Leaflet Technologies, Inc. Leaflet valve
US8637066B2 (en) 2002-10-18 2014-01-28 Depuy Mitek, Llc Biocompatible scaffold for ligament or tendon repair
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US20040078077A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffold for ligament or tendon repair
US9511171B2 (en) 2002-10-18 2016-12-06 Depuy Mitek, Llc Biocompatible scaffolds with tissue fragments
US20040078090A1 (en) * 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US8895045B2 (en) 2003-03-07 2014-11-25 Depuy Mitek, Llc Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof
WO2005004753A1 (en) * 2003-06-09 2005-01-20 3F Therapeutics, Inc. Atrioventricular heart valve and minimally invasive delivery systems thereof
US9211362B2 (en) 2003-06-30 2015-12-15 Depuy Mitek, Llc Scaffold for connective tissue repair
US8226715B2 (en) 2003-06-30 2012-07-24 Depuy Mitek, Inc. Scaffold for connective tissue repair
US20050038520A1 (en) * 2003-08-11 2005-02-17 Francois Binette Method and apparatus for resurfacing an articular surface
US9744059B2 (en) 2003-11-19 2017-08-29 Neovasc Medical Ltd. Vascular implant
US8137702B2 (en) 2003-11-26 2012-03-20 Depuy Mitek, Inc. Conformable tissue repair implant capable of injection delivery
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7875296B2 (en) 2003-11-26 2011-01-25 Depuy Mitek, Inc. Conformable tissue repair implant capable of injection delivery
US8496970B2 (en) 2003-11-26 2013-07-30 Depuy Mitek, Llc Conformable tissue repair implant capable of injection delivery
US20050113937A1 (en) * 2003-11-26 2005-05-26 Francois Binette Conformable tissue repair implant capable of injection delivery
US8641775B2 (en) 2003-12-05 2014-02-04 Depuy Mitek, Llc Viable tissue repair implants and methods of use
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US20050125077A1 (en) * 2003-12-05 2005-06-09 Harmon Alexander M. Viable tissue repair implants and methods of use
US20050149181A1 (en) * 2004-01-07 2005-07-07 Medtronic, Inc. Bileaflet prosthetic valve and method of manufacture
US8721716B2 (en) 2004-01-23 2014-05-13 Edwards Lifesciences Corporation Prosthetic heart valve with dissimilar leaflets
WO2005072654A1 (en) * 2004-01-23 2005-08-11 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US7871435B2 (en) 2004-01-23 2011-01-18 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral heart valve
US20110015731A1 (en) * 2004-01-23 2011-01-20 Edwards Lifesciences Corporation Anatomically Approximate Prosthetic Mitral Valve
US20060293745A1 (en) * 2004-01-23 2006-12-28 Carpentier Alain F Anatomically approximate prosthetic mitral heart valve
US8034104B2 (en) * 2004-01-23 2011-10-11 Edwards Lifesciences Corporation Anatomically approximate prosthetic mitral valve
US20050177249A1 (en) * 2004-02-09 2005-08-11 Kladakis Stephanie M. Scaffolds with viable tissue
US7247167B2 (en) 2004-02-19 2007-07-24 Shlomo Gabbay Low profile heart valve prosthesis
US20050187618A1 (en) * 2004-02-19 2005-08-25 Shlomo Gabbay Low profile heart valve prosthesis
WO2005087140A1 (en) * 2004-03-11 2005-09-22 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US8979922B2 (en) 2004-03-11 2015-03-17 Percutaneous Cardiovascular Solutions Pty Limited Percutaneous heart valve prosthesis
US20050232967A1 (en) 2004-04-20 2005-10-20 Kladakis Stephanie M Nonwoven tissue scaffold
US8137686B2 (en) 2004-04-20 2012-03-20 Depuy Mitek, Inc. Nonwoven tissue scaffold
US8221780B2 (en) 2004-04-20 2012-07-17 Depuy Mitek, Inc. Nonwoven tissue scaffold
US20070031470A1 (en) * 2004-04-20 2007-02-08 Depuy Mitek, Inc. Nonwoven tissue scaffold
US20070067029A1 (en) * 2005-09-16 2007-03-22 Shlomo Gabbay Support apparatus to facilitate implantation of cardiac prosthesis
US20100324668A1 (en) * 2005-10-26 2010-12-23 Cardiosolutions, Inc. Mitral Spacer
US8449606B2 (en) 2005-10-26 2013-05-28 Cardiosolutions, Inc. Balloon mitral spacer
US20070093890A1 (en) * 2005-10-26 2007-04-26 Eliasen Kenneth A Heart valve implant
US8486136B2 (en) 2005-10-26 2013-07-16 Cardiosolutions, Inc. Mitral spacer
US8216302B2 (en) 2005-10-26 2012-07-10 Cardiosolutions, Inc. Implant delivery and deployment system and method
US8506623B2 (en) 2005-10-26 2013-08-13 Cardiosolutions, Inc. Implant delivery and deployment system and method
US20090240326A1 (en) * 2005-10-26 2009-09-24 Cardiosolutions Implant Delivery and Deployment System and Method
US8894705B2 (en) 2005-10-26 2014-11-25 Cardiosolutions, Inc. Balloon mitral spacer
US9232999B2 (en) 2005-10-26 2016-01-12 Cardiosolutions Inc. Mitral spacer
US20070255399A1 (en) * 2005-10-26 2007-11-01 Eliasen Kenneth A Balloon Mitral Spacer
US20090043382A1 (en) * 2005-10-26 2009-02-12 Cardiosolutions, Inc. Mitral Spacer
US8888844B2 (en) 2005-10-26 2014-11-18 Cardiosolutions, Inc. Heart valve implant
US20070265700A1 (en) * 2005-10-26 2007-11-15 Eliasen Kenneth A Safety for Mitral Valve Plug
US8092525B2 (en) 2005-10-26 2012-01-10 Cardiosolutions, Inc. Heart valve implant
US8778017B2 (en) 2005-10-26 2014-07-15 Cardiosolutions, Inc. Safety for mitral valve implant
US7785366B2 (en) 2005-10-26 2010-08-31 Maurer Christopher W Mitral spacer
US9517129B2 (en) 2005-10-26 2016-12-13 Cardio Solutions, Inc. Implant delivery and deployment system and method
US9486336B2 (en) 2005-11-10 2016-11-08 Edwards Lifesciences Cardiaq Llc Prosthesis having a plurality of distal and proximal prongs
US9433514B2 (en) 2005-11-10 2016-09-06 Edwards Lifesciences Cardiaq Llc Method of securing a prosthesis
US9844434B2 (en) 2006-10-06 2017-12-19 BioStable Science & Engineering, Inc. Intra-annular mounting frame for aortic valve repair
US20080288061A1 (en) * 2007-05-14 2008-11-20 Maurer Christopher W Solid Construct Mitral Spacer
US8480730B2 (en) 2007-05-14 2013-07-09 Cardiosolutions, Inc. Solid construct mitral spacer
US8852270B2 (en) 2007-11-15 2014-10-07 Cardiosolutions, Inc. Implant delivery system and method
US20090132033A1 (en) * 2007-11-15 2009-05-21 Cardiosolutions, Inc. Implant Delivery System and Method
US9770330B2 (en) 2007-11-15 2017-09-26 Cardiosolutions, Inc. Implant delivery system and method
US8597347B2 (en) 2007-11-15 2013-12-03 Cardiosolutions, Inc. Heart regurgitation method and apparatus
US20090131849A1 (en) * 2007-11-15 2009-05-21 Cardiosolutions, Inc. Heart regurgitation method and apparatus
US9259317B2 (en) 2008-06-13 2016-02-16 Cardiosolutions, Inc. System and method for implanting a heart implant
US20100022948A1 (en) * 2008-06-13 2010-01-28 Cardiosolutions Steerable Catheter and Dilator and System and Method for Implanting a Heart Implant
US8591460B2 (en) 2008-06-13 2013-11-26 Cardiosolutions, Inc. Steerable catheter and dilator and system and method for implanting a heart implant
US20090048668A1 (en) * 2008-06-13 2009-02-19 Cardiosolutions, Inc. System and Method for Implanting a Heart Implant
US9456896B2 (en) 2008-09-29 2016-10-04 Edwards Lifesciences Cardiaq Llc Body cavity prosthesis
US9597183B2 (en) 2008-10-01 2017-03-21 Edwards Lifesciences Cardiaq Llc Delivery system for vascular implant
US9339379B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9339380B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant
US9339378B2 (en) 2009-04-15 2016-05-17 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9333073B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery method
US9333074B2 (en) 2009-04-15 2016-05-10 Edwards Lifesciences Cardiaq Llc Vascular implant and delivery system
US9585747B2 (en) 2009-04-15 2017-03-07 Edwards Lifesciences Cardiaq Llc Vascular implant
US9730790B2 (en) 2009-09-29 2017-08-15 Edwards Lifesciences Cardiaq Llc Replacement valve and method
US9480560B2 (en) 2009-09-29 2016-11-01 Edwards Lifesciences Cardiaq Llc Method of securing an intralumenal frame assembly
US9241790B2 (en) 2010-05-05 2016-01-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9770329B2 (en) 2010-05-05 2017-09-26 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9248014B2 (en) 2010-05-05 2016-02-02 Neovasc Tiara Inc. Transcatheter mitral valve prosthesis
US9161835B2 (en) 2010-09-30 2015-10-20 BioStable Science & Engineering, Inc. Non-axisymmetric aortic valve devices
US9814574B2 (en) 2010-09-30 2017-11-14 BioStable Science & Engineering, Inc. Non-axisymmetric aortic valve devices
JP2013542764A (en) * 2010-09-30 2013-11-28 バイオステイブル サイエンス アンド エンジニアリング インコーポレイテッド Aortic valve device
US20120143324A1 (en) * 2010-09-30 2012-06-07 BioStable Science & Engineering, Inc. Aortic Valve Devices
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9713529B2 (en) 2011-04-28 2017-07-25 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US20140155990A1 (en) * 2012-05-30 2014-06-05 Neovasc Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9345573B2 (en) * 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9730791B2 (en) 2013-03-14 2017-08-15 Edwards Lifesciences Cardiaq Llc Prosthesis for atraumatically grasping intralumenal tissue and methods of delivery
US9681951B2 (en) 2013-03-14 2017-06-20 Edwards Lifesciences Cardiaq Llc Prosthesis with outer skirt and anchors
US9833316B2 (en) 2013-03-15 2017-12-05 Cardiosolutions, Inc. Trans-apical implant systems, implants and methods
US9232998B2 (en) 2013-03-15 2016-01-12 Cardiosolutions Inc. Trans-apical implant systems, implants and methods
US9289297B2 (en) 2013-03-15 2016-03-22 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US20160143730A1 (en) * 2013-06-14 2016-05-26 Arash Kheradvar Transcatheter mitral valve
WO2014201384A1 (en) * 2013-06-14 2014-12-18 The Regents Of The University Of California Transcatheter mitral valve
US9545305B2 (en) 2013-06-14 2017-01-17 Cardiosolutions, Inc. Mitral valve spacer and system and method for implanting the same
USD755384S1 (en) 2014-03-05 2016-05-03 Edwards Lifesciences Cardiaq Llc Stent
WO2016114928A1 (en) * 2015-01-13 2016-07-21 Horizon Scientific Corp. Mitral bileaflet valve

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