US3738372A - Apparatus for application of local hypothermy to the kidney - Google Patents

Apparatus for application of local hypothermy to the kidney Download PDF

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US3738372A
US3738372A US00217565A US3738372DA US3738372A US 3738372 A US3738372 A US 3738372A US 00217565 A US00217565 A US 00217565A US 3738372D A US3738372D A US 3738372DA US 3738372 A US3738372 A US 3738372A
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kidney
heat exchanger
refrigerant
hypothermy
local
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T Shioshvili
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/10—Cooling bags, e.g. ice-bags
    • A61F2007/101—Cooling bags, e.g. ice-bags for cooling organs in the body before or during surgery

Definitions

  • a heat-exchanger to cool down the kidney, which is essentially a big-diameter plastic tube, wherealong refrigerant or cooling agent is free to circulate.
  • the tube embraces the kidney as a ring and due to being in permanent contact therewith, cools it down.
  • said known apparatus suffers from the disadvantage that the distal margin, the portal region or the hilum renis and partly the poles of the kidney, i.e., about 30 percent its external surface, prove to be out of contact with the cooling tube, which results in an inadequate cooling of the kidney and, consequently, in a low rate of cooling thereof.
  • the heat exchanger is made as two hemispheres formed by a coiler element made of a plastic tube, wherealong refrigerant is under circulation.
  • the kidney being cooled, when placed in between said hemispheres, is in contact with the heat exchanger with but separate areas of its outer surface, this being due to the spherical-shape heat exchanger that is out of correspondence with the shape of the kidney and, besides, due to the fact that the tubes forming the hemispheres, contact the kidney only along the tangential lines.
  • the heat exchangeris composed of two stainless-steel members forming a confined space or chamher, said members being kidney-shaped and having double walls for the refrigerant to circulate therebetween.
  • a disadvantage inherent in the aforesaid heat exchanger resides in the fact that even a great number of diversely shaped heat exchangers will fail to cover a variety of sizes and shapes of the renal curvature with the result that said heat exchangers provide the contact of the kidney with the walls of the heat exchanger only at some separate points.
  • an apparatus for the application of local hypothermy to the kidney comprising a cooling heat exchanger made as a confined space or chamber having double walls for the refigerant to circulate therebetween and the inside surface whose shape corresponds to the renal shape, and also incorporating a reservoir for the refrigerant to hold and a pump for the refrigerant to recirculate between the cooling heat exchanger and the refrigerantcontaining reservoir, according to the invention the walls of the cooling heat exchanger are made of an elastic material.
  • the walls of the cooling heat exchanger be made of rubber.
  • FIG. 1 diagrammatically illustrates an apparatus for the application of local hypothermy to the kidney, according to the invention
  • FIG. 2 is an enlarged-scale view of the heat exchanger of the apparatus, showing its wallpartly cut away, according to the invention.
  • FIG. 3 is a diagrammatic cross-sectional view of the heat-exchanger walls, taken through the refrigerantcarrying tubes, according to the invention.
  • the apparatus for the application of local hypothermy to the kidney comprises a refrigerant tank 1 which is essentially a Dewar vacuum flask provided with. a' union 2 at the bottom thereof, connected to a rubber tube 3 part of which is accommodated inside the housing of a rotary roller pump 4. Rollers 5 of the pump 4 with their spindles 6 are fixed to a hub 7 set on a shaft 8 of a speed reducer 9; the latter is connected to a shaft 10 of an electric' chamber whose inner surface is shaped to suit the shape ofa kidney.
  • a wedge-like recess 17 (FIG. 2) made in the heat exchanger 12 is for convenience in the application of a clamp to the vascular pedicle or the crus renis.
  • the heat exchanger 12 has also slots 18 to facilitate fitting of the heat exchanger 12 onto the kidney.
  • the apparatus for the application of local hypothermy to the kidney operates as follows.
  • the tank 1 (FIG. 1) is filled with the refrigerant, viz., a 96-percent ethanol cooled down to lC.
  • the electric motor 11 is switched on to impart rotation via the speed reducer 9 to the hub 7 connected to the rollers 5.
  • the rollers 5 ride on the tube 3 in the direction indicated with the arrow in the Figure, thus forcing said tube to the inner wall of the housing of the rotary roller pump 4.
  • the refrigerant from the tank 1 is forced out along the tube 3 to the heat exchanger 12 which is fitted onto the kidney being cooled. From the heat exchanger 12 the refrigerant flows along the tube 16 to return into the tank 1.
  • the degree of filling of the space 15 of the heat exchanger 12 with the refrigerant depends upon the extent to which the tube 16 is compressed or pinched.
  • the inner elastic jacket 14 of the heat exchanger- 12 is made to snugly fit to the kidney over the entire surface thereof which provides for the best conditions for an adequate and rapid heat extraction from the kidney to apply hypothermy thereto.
  • the elastic jackets 13 and 14 of the heat exchanger 12 are made of rubber, their optimum thickness being 0.4-0.7 mm which enables both the required strength and heat conductance of the walls of the heat exchanger 12 to be attained.

Abstract

An apparatus for the application of local hypothermy to the kidney, comprising a kidney-cooling heat exchanger made as a confined chamber whose inside surface is so shaped as to suit the renal shape. The walls of the cooling heat exchanger are made double for the refrigerant to circulate therebetween, and fabricated from an elastic material.

Description

United States Patent 1191 Shioshvili 1 APPARATUS FOR APPLICATION OF LOCAL HYPOTHERMY TO THE KIDNEY [76] Inventor: Tamaz Iosifovich Shioshvili, ul. Barnova, 148, kv. l7, Tbilisi,
USSR.
[22] Filed: Jan. 13, 1972 21 Appl. No.: 217,565
[52] U.S. c1. 128/400, 128/402 [51] 1111. c1. A611 7/00 [58] Field of Search 128/400, 402, 258,
[5 6] References Cited UNITED STATES PATENTS 2,260,134 10/1941 Ballman 128/400 [11] 3,738,372 June 12, 1973 3,091,242 5/1963 Johnson et al 128/402 1,896,953 2/1933 Hassell 128/400 X 3,238,944 3/1966 Hirschhom 128/400 Primary Examiner-Lawrence W. Trapp Attorney-Eric H. Waters, John G. Schivartz and .1.
Harold Nissen [57] 1 ABSTRACT An apparatus for the application of local hypothermy to the kidney, comprising a kidney-cooling heat exchanger made as a confined chamber whose inside surface is so shaped as to suit the renal shape. The walls of the cooling heat exchanger are made double for the refrigerant to circulate therebetween, and fabricated from an elastic material.
2 Claims, 3 Drawing Figures APPARATUS FOR APPLICATION OF LOCAL HYPOTHERMY TO THE KIDNEY This invention relates generally to the art of medicine and has particular reference to apparatus for applying local hypothermy to the kidney excluded from the blood circulation.
Known in the present day medical practice is an apparatus for applying local hypothermy to the kidney, comprising a heat-exchanger to cool down the kidney, which is essentially a big-diameter plastic tube, wherealong refrigerant or cooling agent is free to circulate. The tube embraces the kidney as a ring and due to being in permanent contact therewith, cools it down.
However, said known apparatus suffers from the disadvantage that the distal margin, the portal region or the hilum renis and partly the poles of the kidney, i.e., about 30 percent its external surface, prove to be out of contact with the cooling tube, which results in an inadequate cooling of the kidney and, consequently, in a low rate of cooling thereof.
Another apparatus of the characterset forth above is now known to be used, wherein the heat exchanger is made as two hemispheres formed by a coiler element made of a plastic tube, wherealong refrigerant is under circulation. The kidney being cooled, when placed in between said hemispheres, is in contact with the heat exchanger with but separate areas of its outer surface, this being due to the spherical-shape heat exchanger that is out of correspondence with the shape of the kidney and, besides, due to the fact that the tubes forming the hemispheres, contact the kidney only along the tangential lines.
One more apparatus for the application of hypothermy to the kidney is known to use heretofore,
. wherein the heat exchangeris composed of two stainless-steel members forming a confined space or chamher, said members being kidney-shaped and having double walls for the refrigerant to circulate therebetween.
A disadvantage inherent in the aforesaid heat exchanger resides in the fact that even a great number of diversely shaped heat exchangers will fail to cover a variety of sizes and shapes of the renal curvature with the result that said heat exchangers provide the contact of the kidney with the walls of the heat exchanger only at some separate points.
Thus, due to inadequate contact with the surface, none of the hitherto known apparatus is capable of uniforrnly reducing the temperature of the kidney from 37 down to 20C within a period of time shorter than 8-10 minutes.
Such a low rate of cooling is undesirable not only on account of the fact that is prolongs the period of useless ischaemia and delays the operation but, largely, due to the fact that low cooling rate of the kidney being operated prolongs the period of discrepancy between high energy demand of the renal tissue and a limited amount of energy sources. Thus, even a 8l0-minute period of renal ischaemia occurring in an inadequately cooled .kidney, entails adverse functional sequelae; therefore,
cutting down of the cooling period by every minute is conducive to the successful outcome of the operation.
On the other hand, too high a cooling rate attainable due to the use of more frigorific refrigerants may inflict acceleration of the cooling rate is the attaining of a full contact of the refrigerant with the renal surface and, thereby, more complete heat transfer process.
It is therefore an essential object of the present invention to provide such an apparatus for the application of local hypothermy to the kidney that would comprise a heat exchanger capable of an adequate and safeful cooling of the human kidney of any size and configuration, this being due to a complete adherence of the walls thereof to the entire external renal surface and more perfect heat transfer process.
Said object is accomplished due to the fact that in an apparatus for the application of local hypothermy to the kidney, comprising a cooling heat exchanger made as a confined space or chamber having double walls for the refigerant to circulate therebetween and the inside surface whose shape corresponds to the renal shape, and also incorporating a reservoir for the refrigerant to hold and a pump for the refrigerant to recirculate between the cooling heat exchanger and the refrigerantcontaining reservoir, according to the invention the walls of the cooling heat exchanger are made of an elastic material.
It is expedient that the walls of the cooling heat exchanger be made of rubber.
In the herein-proposed apparatus, when the heat exchanger is moderately filled with refrigerant, a close adherence of the inside surface thereof to the kidney is attained, which establishes the best conditions for a uniform, quick and safe heat transfer to occur. This enables a 3-4 fold increase in the renal cooling rate as compared to the best of the hitherto-known apparatus of similar purpose.
cold injury upon the kidney (cold ulcers, spasms of blood vessels); that is why the optimal way of maximum The apparatus is able to adequately and safely cool the kidney of an adult from 37 down to 20 within 23.5 minutes and the kidney ofa child, for l-l .5 minutes. When used in experiments on dogs the apparatus is instrumental in cooling down the kidney from 37 to FIG. 1 diagrammatically illustrates an apparatus for the application of local hypothermy to the kidney, according to the invention;
FIG. 2 is an enlarged-scale view of the heat exchanger of the apparatus, showing its wallpartly cut away, according to the invention; and
FIG. 3 is a diagrammatic cross-sectional view of the heat-exchanger walls, taken through the refrigerantcarrying tubes, according to the invention.
Now referring to the Drawings, the apparatus for the application of local hypothermy to the kidney comprises a refrigerant tank 1 which is essentially a Dewar vacuum flask provided with. a' union 2 at the bottom thereof, connected to a rubber tube 3 part of which is accommodated inside the housing of a rotary roller pump 4. Rollers 5 of the pump 4 with their spindles 6 are fixed to a hub 7 set on a shaft 8 of a speed reducer 9; the latter is connected to a shaft 10 of an electric' chamber whose inner surface is shaped to suit the shape ofa kidney. A space 15 confined in between the elastic jackets l3 and 14 communicates with the tube 3 running from the rotary roller pump 4 and with a tube 16 through which the space 15 communicates with the tank 1, both of the tubes 3 and 16 being connected to the space 15 in such a way as to let the refrigerant fillthe entire space 15.
A wedge-like recess 17 (FIG. 2) made in the heat exchanger 12 is for convenience in the application of a clamp to the vascular pedicle or the crus renis.
The heat exchanger 12 has also slots 18 to facilitate fitting of the heat exchanger 12 onto the kidney.
The apparatus for the application of local hypothermy to the kidney operates as follows.
The tank 1 (FIG. 1) is filled with the refrigerant, viz., a 96-percent ethanol cooled down to lC.
Then the electric motor 11 is switched on to impart rotation via the speed reducer 9 to the hub 7 connected to the rollers 5. The rollers 5 ride on the tube 3 in the direction indicated with the arrow in the Figure, thus forcing said tube to the inner wall of the housing of the rotary roller pump 4. As a result, the refrigerant from the tank 1 is forced out along the tube 3 to the heat exchanger 12 which is fitted onto the kidney being cooled. From the heat exchanger 12 the refrigerant flows along the tube 16 to return into the tank 1. The
- refrigerant passing through the space (FIG. 2) of the heat exchanger 12 and the surface of the heat exchanger 12 contacting the kidney, have a temperature from +1 to +3C.
The degree of filling of the space 15 of the heat exchanger 12 with the refrigerant depends upon the extent to which the tube 16 is compressed or pinched. When the space 15 is moderately filled with the refrigerant, the inner elastic jacket 14 of the heat exchanger- 12 is made to snugly fit to the kidney over the entire surface thereof which provides for the best conditions for an adequate and rapid heat extraction from the kidney to apply hypothermy thereto.
The elastic jackets 13 and 14 of the heat exchanger 12 are made of rubber, their optimum thickness being 0.4-0.7 mm which enables both the required strength and heat conductance of the walls of the heat exchanger 12 to be attained.
The use of rubber as the material of the heat exchanger is due to its high elasticity and resilience which makes it possible to easily control the degree of filling of the heat exchanger 12 during the operation of the apparatus to suit the size and shape of the kidney being cooled.
I claim:
1. An apparatus for the application of local hypothermy to the kidney, comprising: a cooling heat exchanger made as a confined chamber whose inside surface is so shaped as to suit the renal shape; double walls of said cooling heat exchanger adapted for the refrigerant to circulate therebetween and made of an elastic material; a recess made in said cooling heat exchanger for the kidney to accommodate; a refrigerant tank; a pump for the refrigerant to recirculate between said tank and said cooling heat exchanger.
2. An apparatus as claimed in claim 1, wherein said double walls of the cooling heat exchanger are made of rubber.

Claims (2)

1. An apparatus for the application of local hypothermy to the kidney, comprising: a cooling heat exchanger made as a confined chamber whose inside surface is so shaped as to suit the renal shape; double walls of said cooling heat exchanger adapted for the refrigerant to circulate therebetween and made of an elastic material; a recess made in said cooling heat exchanger for the kidney to accommodate; a refrigerant tank; a pump for the refrigerant to recirculate between said tank and said cooling heat exchanger.
2. An apparatus as claimed in claim 1, wherein said double walls of the cooling heat exchanger are made of rubber.
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Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865116A (en) * 1973-04-09 1975-02-11 Harold W Brooks Method of controlling tissue hypothermia
US3967627A (en) * 1974-11-18 1976-07-06 Moore-Perk Corporation Hot/cold applicator system
US4111209A (en) * 1977-04-18 1978-09-05 Datascope Corporation Topical hypothermia apparatus and method for treating the human body and the like
US4154245A (en) * 1977-07-11 1979-05-15 Daily Pat O Apparatus for local hypothermia
DE3002496A1 (en) * 1979-01-24 1980-07-31 Cobe Lab COOLING DEVICE FOR MEDICAL PURPOSES
US4335726A (en) * 1980-07-11 1982-06-22 The Kendall Company Therapeutic device with temperature and pressure control
US4338944A (en) * 1980-06-16 1982-07-13 The Kendall Company Therapeutic device
US4605006A (en) * 1984-02-28 1986-08-12 Minnesota Mining And Manufacturing Company Hypothermic protection pad
US4934996A (en) * 1984-02-27 1990-06-19 Boston Scientific Corporation Pressure-controlled intermittent coronary sinus occlusion apparatus and method
US4969470A (en) * 1984-02-27 1990-11-13 Boston Scientific Corporation Heart analysis using pressure-controlled intermittent coronary sinus occlusion
US4971056A (en) * 1989-08-07 1990-11-20 Daily Medical Products Incorporated Arcuate shaped cooling jacket
US5014695A (en) * 1988-10-04 1991-05-14 Benak Arnold M Kidney cooling jacket
US5174285A (en) * 1990-01-08 1992-12-29 Lake Shore Medical Development Partners Ltd. Localized heat transfer device
US6165207A (en) * 1999-05-27 2000-12-26 Alsius Corporation Method of selectively shaping hollow fibers of heat exchange catheter
US6197045B1 (en) 1999-01-04 2001-03-06 Medivance Incorporated Cooling/heating pad and system
US6287326B1 (en) 1999-08-02 2001-09-11 Alsius Corporation Catheter with coiled multi-lumen heat transfer extension
US6299599B1 (en) 1999-02-19 2001-10-09 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6368304B1 (en) 1999-02-19 2002-04-09 Alsius Corporation Central venous catheter with heat exchange membrane
US6375674B1 (en) 1999-01-04 2002-04-23 Medivance, Inc. Cooling/heating pad and system
US6393320B2 (en) 1999-02-19 2002-05-21 Alsius Corporation Method for treating cardiac arrest
US6409747B1 (en) 1998-04-21 2002-06-25 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6419643B1 (en) 1998-04-21 2002-07-16 Alsius Corporation Central venous catheter with heat exchange properties
US6447474B1 (en) 1999-09-15 2002-09-10 Alsius Corporation Automatic fever abatement system
US6450990B1 (en) 1998-08-13 2002-09-17 Alsius Corporation Catheter with multiple heating/cooling fibers employing fiber spreading features
US6458150B1 (en) 1999-02-19 2002-10-01 Alsius Corporation Method and apparatus for patient temperature control
US6474093B1 (en) 2000-10-23 2002-11-05 Cosmo Tech Development, Inc. Expanding barrel system for cooling beverages
US6572640B1 (en) 2001-11-21 2003-06-03 Alsius Corporation Method and apparatus for cardiopulmonary bypass patient temperature control
US6582398B1 (en) 1999-02-19 2003-06-24 Alsius Corporation Method of managing patient temperature with a heat exchange catheter
US6589271B1 (en) 1998-04-21 2003-07-08 Alsius Corporations Indwelling heat exchange catheter
US6716236B1 (en) 1998-04-21 2004-04-06 Alsius Corporation Intravascular catheter with heat exchange element having inner inflation element and methods of use
US20040127851A1 (en) * 2002-12-31 2004-07-01 Alsius Corporation System and method for controlling rate of heat exchange with patient
US20060036303A1 (en) * 1999-06-08 2006-02-16 Schwartz Arthur E Intravascular systems for corporeal cooling
US20060089689A1 (en) * 2004-10-22 2006-04-27 Hennemann Willard W Method and device for local cooling within an organ using an intravascular device
US20060111764A1 (en) * 2004-11-19 2006-05-25 Seacoast Technologies, Inc. Medical device having a dual fluid circulation structure for thermally affecting tissue
US7077825B1 (en) 2002-01-16 2006-07-18 Radiant Medical, Inc. Method for gastric cooling using balloon catheter
CN100431505C (en) * 2003-12-26 2008-11-12 日本麦迪科思株式会社 Heating-type balloon catheter device, and elastic tube device and vibrator device for the cathter device
US20090182400A1 (en) * 2002-04-10 2009-07-16 Zoll Circulation, Inc. Methods and systems for reducing substance-induced renal damage
US8128595B2 (en) 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US8308710B2 (en) 2001-10-12 2012-11-13 Applied Medical Resources Corporation High flow-low pressure irrigation system
CN105232214A (en) * 2015-09-01 2016-01-13 胡卫列 Kidney cooling capsule
US10420675B2 (en) 2002-01-16 2019-09-24 Zoll Circulation, Inc. Apparatus and method for esophageal cooling

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US1896953A (en) * 1931-05-18 1933-02-07 Hassell Cecil Starke Electric ice cap
US2260134A (en) * 1939-10-27 1941-10-21 William H Ballman Body pad
US3091242A (en) * 1960-04-04 1963-05-28 Garrett Corp Apparatus for local hypothermia
US3238944A (en) * 1962-10-08 1966-03-08 Max L Hirschhorn Temperature controlling device for living organs

Cited By (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865116A (en) * 1973-04-09 1975-02-11 Harold W Brooks Method of controlling tissue hypothermia
US3967627A (en) * 1974-11-18 1976-07-06 Moore-Perk Corporation Hot/cold applicator system
US4111209A (en) * 1977-04-18 1978-09-05 Datascope Corporation Topical hypothermia apparatus and method for treating the human body and the like
US4154245A (en) * 1977-07-11 1979-05-15 Daily Pat O Apparatus for local hypothermia
DE3002496A1 (en) * 1979-01-24 1980-07-31 Cobe Lab COOLING DEVICE FOR MEDICAL PURPOSES
US4259961A (en) * 1979-01-24 1981-04-07 Hood Iii Andrew G Cooling pad
US4338944A (en) * 1980-06-16 1982-07-13 The Kendall Company Therapeutic device
US4335726A (en) * 1980-07-11 1982-06-22 The Kendall Company Therapeutic device with temperature and pressure control
US4934996A (en) * 1984-02-27 1990-06-19 Boston Scientific Corporation Pressure-controlled intermittent coronary sinus occlusion apparatus and method
US4969470A (en) * 1984-02-27 1990-11-13 Boston Scientific Corporation Heart analysis using pressure-controlled intermittent coronary sinus occlusion
US4605006A (en) * 1984-02-28 1986-08-12 Minnesota Mining And Manufacturing Company Hypothermic protection pad
US5014695A (en) * 1988-10-04 1991-05-14 Benak Arnold M Kidney cooling jacket
US4971056A (en) * 1989-08-07 1990-11-20 Daily Medical Products Incorporated Arcuate shaped cooling jacket
US5174285A (en) * 1990-01-08 1992-12-29 Lake Shore Medical Development Partners Ltd. Localized heat transfer device
US5344436A (en) * 1990-01-08 1994-09-06 Lake Shore Medical Development Partners, Ltd. Localized heat transfer device
US6755851B2 (en) 1998-04-21 2004-06-29 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6716236B1 (en) 1998-04-21 2004-04-06 Alsius Corporation Intravascular catheter with heat exchange element having inner inflation element and methods of use
US6652565B1 (en) 1998-04-21 2003-11-25 Alsius Corporation Central venous catheter with heat exchange properties
US6589271B1 (en) 1998-04-21 2003-07-08 Alsius Corporations Indwelling heat exchange catheter
US8128595B2 (en) 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US6419643B1 (en) 1998-04-21 2002-07-16 Alsius Corporation Central venous catheter with heat exchange properties
US6409747B1 (en) 1998-04-21 2002-06-25 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6450990B1 (en) 1998-08-13 2002-09-17 Alsius Corporation Catheter with multiple heating/cooling fibers employing fiber spreading features
US6197045B1 (en) 1999-01-04 2001-03-06 Medivance Incorporated Cooling/heating pad and system
US6375674B1 (en) 1999-01-04 2002-04-23 Medivance, Inc. Cooling/heating pad and system
US6582398B1 (en) 1999-02-19 2003-06-24 Alsius Corporation Method of managing patient temperature with a heat exchange catheter
US6458150B1 (en) 1999-02-19 2002-10-01 Alsius Corporation Method and apparatus for patient temperature control
US6393320B2 (en) 1999-02-19 2002-05-21 Alsius Corporation Method for treating cardiac arrest
US6516224B2 (en) 1999-02-19 2003-02-04 Alsius Corporation Method for treating cardiac arrest
US6368304B1 (en) 1999-02-19 2002-04-09 Alsius Corporation Central venous catheter with heat exchange membrane
US6299599B1 (en) 1999-02-19 2001-10-09 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6620131B2 (en) 1999-02-19 2003-09-16 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6165207A (en) * 1999-05-27 2000-12-26 Alsius Corporation Method of selectively shaping hollow fibers of heat exchange catheter
US20060036303A1 (en) * 1999-06-08 2006-02-16 Schwartz Arthur E Intravascular systems for corporeal cooling
US6287326B1 (en) 1999-08-02 2001-09-11 Alsius Corporation Catheter with coiled multi-lumen heat transfer extension
US6447474B1 (en) 1999-09-15 2002-09-10 Alsius Corporation Automatic fever abatement system
US20030167034A1 (en) * 1999-09-15 2003-09-04 Balding David P. Automatic fever abatement applications
US6474093B1 (en) 2000-10-23 2002-11-05 Cosmo Tech Development, Inc. Expanding barrel system for cooling beverages
US8308710B2 (en) 2001-10-12 2012-11-13 Applied Medical Resources Corporation High flow-low pressure irrigation system
US6572640B1 (en) 2001-11-21 2003-06-03 Alsius Corporation Method and apparatus for cardiopulmonary bypass patient temperature control
US20060253095A1 (en) * 2002-01-16 2006-11-09 Radiant Medical, Inc. Method for gastric cooling using balloon catheter
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