US3659615A - Encapsulated non-permeable piezoelectric powered pacesetter - Google Patents

Encapsulated non-permeable piezoelectric powered pacesetter Download PDF

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US3659615A
US3659615A US3659615DA US3659615A US 3659615 A US3659615 A US 3659615A US 3659615D A US3659615D A US 3659615DA US 3659615 A US3659615 A US 3659615A
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living
piezoelectric
generator
wax
envelope
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Carl C Enger
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Carl C Enger
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/378Electrical supply
    • A61N1/3785Electrical supply generated by biological activity or substance, e.g. body movement

Abstract

An encapsulated non-permeable piezoelectric self-powered pacesetter for implantation in an in vivo, or living, system in which the pacesetter is sealed and enclosed in an envelope formed of medical grade silicone rubber and preferably natural or synthetic animal, plant or insect wax, in which a piezoelectric poly-crystalline ceramic is completely embedded, enclosed or housed to function as a mechanical to electrical energy converter, when implanted near moving muscle in a living system, and without connection with a separate source of electrical energy either within or without the living system.

Description

United States Patent Enger [54] ENCAPSULATED NON-PERMEABLE PIEZOELECTRIC POWERED PACESETTER [72] inventor: Carl C. Enger, 12700 Lake Avenue, Lakewood, Ohio 44107 [22] Filed: June 8, 1970 [2 1] Appl. No.: 44,406

52 us. 01 ..l28/419 P, 128/419 B 51 1m. (:1. ..A61n 1/36 58 Field ofSearch ..12s/419 P, 419 B, 421,422,

[56] References Cited UNITED STATES PATENTS 3,486,506 12/1969 Auphan ..128/4l9 P PIEZOELECTRIC 20 UNIT 1451 May 2,1972

3,456,!34 7/1969 K0 ..l28/4l9P Primary Examiner-William E. Kamm Attorney-Arthur H. Van Horn [57] ABSTRACT An encapsulated non-permeable piezoelectric self-powered 'pacesetter for implantation in an in vivo, or living, system in which the pacesetter is sealed and enclosed in an envelope 5 Claims, 3 Drawing Figures Patented May 2, 1972 F IG.|

:l8' I PIEZOELECTRIC P20 l4 UNIT FIG.2

INVENTOR. CARL C. EN G E R @MMK ATTORNEY.

ENCAPSULATED NON-PERMEABLE PIEZOELECTRIC POWERED PACESETTER THE INVENTION This invention relates to pacesetters and more particularly to the encapsulated type enclosing a piezoelectric polycrystalline ceramic mechanical to electrical energy converter wherein the enclosure consists of a non-penneable envelope formed of medical grade silicone rubber and natural or synthetic animal, plant or insect wax to provide a compatible ion obstructing or excluding interface between living tissue and the implant.

The invention embodies two forms, one of which may consist of a material of uniformly integrated medical grade silicone rubber and one or more natural or synthetic waxes of the type disclosed, or another form consisting of a moulded wax providing a highly non-permeable coating to prevent transfer of relatively highly reactive electrolytes or other conductive moisture from entering the areas in which the piezoelectric unit and its associated electrical components are enclosed. The outer cover or envelope of medical grade silicone rubber must be compatible with living tissue, while the inner envelope provides a non-permeable coating for the implantable electrical devices associated with the piezoelectrical generator.

THE DRAWING .closing envelope is formed of an inner body of moulded wax and an outer covering layer of medical grade silicone rubber.

DESCRIPTION The figures illustrate forms of the invention which include an encapsulation constructed of materials compatible with living tissue with which they come into contact by implantation in a living system. While the invention is especially useful as a heart pacesetter for implantation in the chest cavity or ad jacent to the heart left ventricle, it is equally useful in other muscular areas of the living system by implantation to stimulate and regulate muscular activity as, for instance, pacing the bladder, blood pressure control centers of the circulatory system, gastro-intestinal tract, the pancreas and other electrically controlled organs of the living system.

Due to its miniature size and compactness, relatively light weight, non-permeability to body fluids and its ability to obstruct or exclude ion passage therethrough, it is readily adaptable to these many uses.

In the drawing, first referring to FIGS. 1 and 2, illustrating a simplified and preferred form of the invention. In this embodiment, which is shown somewhat enlarged for clearness, the encapsulation is indicated generally at 10 and is formed of a mass composed of substantially uniformly and intimately in tegrated medical grade silicone rubber and one or more natural waxes of the type herein disclosed, imparting a material having high non-permeable qualities to prevent transfer of highly reactive electrolytes or other conductive moisture from entering the areas in which the piezoelectric generator unit and its associated electrical components are enclosed, yet possessing flexibility sufficient to react to muscular movement in the area of its implantation, in a living system. Such material is found to be compatible with living tissue with which it comes into contact.

A transducer comprising elements 12 extend longitudinally along and within the encapsulation l and have imput electrical connection with a conventional piezoelectric generator unit 16 through electrodes of platinum or other suitable tissuecompatible conductors 18 and 20. Electrodes l8 and 20', respectively, are electrically connected with the output side of the unit 16 for purposes of delivering electrical impulses to the specific part of the body or living system in which the electrodes are implanted.

It is essential that the piezoelectric generator which is of very high impedance have a relatively slight ability to flex or bend in use to actively generate electrical energy. This is ensured by its encapsulation in a moulded or formed envelope 14 as disclosed herein.

The encapsulation 14 is preferably formed of either plant, insect or animal wax as distinguished from synthetic wax materials, to provide a highly non-permeable housing for the piezoelectric unit 16 and the transducer element 12 to prevent transfer of highly reactive electrolytes or other conductive moisture from entering the interior of the encapsulation 10.

Electrical generators such as piezoelectric bimorphs 12 have internal impedances of approximately 20 megohms and are adequate, for instance, for implantation in beeswax. Spermaciti, a mammal wax, also provides suitable non-permeable qualities and such waxes are compatible with living tissue. 1 have found that a thickness of non-permeable wax of the group referred to, when applied in a thickness of from 0.15 to 0.50 inch, is quite satisfactory.

l have found that the use of synthetic waxes as encapsulants are permeated by ions under the conditions of use in a living system and they do not maintain sufficient dielectric properties over a long period of implantation.

In FIG. 3 is illustrated an embodiment 10a which in many respects is similar to that described above in connection with the description of FIGS. 1 and 2, but differs in that an outer envelope of medical grade silicone rubber 22 completely encloses the inner core or encapsulation surrounding the piezoelectric unit and transducer elements 12a and provides a compatible, non-toxic interface between the implant and the living tissue in contact therewith.

The thickness of the envelope 22 may vary from 0.30 to 0.10 inch, depending upon the location of the implant or the mechanical requirements. The outer cover 22 also serves as a protective layer over the inner wax encapsulation 14a against abrasion that otherwise could occur in the presence of moving muscle or tissue.

I claim: 7

1. An encapsulated pacesetter implantable in a living system and responsive to movement of an organic muscle to which it is applied to stimulate and pace the natural movement of the muscle, said pacesetter comprising a piezoelectric unit, a transducer, input electrodes electrically connecting said transducer with said generator unit, generator output electrodes for implantation in the muscle tissue, an encapsulating envelope completely enclosing said pacesetter, said envelope formed of a living tissue compatible material consisting of medical grade silicone rubber and a natural wax substantially uniformly and intimately integrated together as a material possessing flexibility sufficient to respond to movement of the muscle tissue in which it is implanted.

2. The invention as defined in claim 1 in which said envelope comprises a natural wax inner enclosure for the generator and the transducer and a medical grade silicone rubber, outer, living tissue compatible envelope.

3. The invention defined in claim 1 in which the material forming the capsule consists of a natural wax and medical grade silicone rubber intimately and uniformly dispersed throughout the total mass to form an envelope.

4. An encapsulated pacesetter comprising an elongate capsule enclosing a piezoelectric generator unit at one end of the capsule, a transducer unit enclosed in the capsule and extending in a direction from said capsule end enclosing said generator to provide a flat flexing portion responsive to movement of organic muscle tissue in which the device is implanted in close proximity thereto, input electrodes within the capsule electrically connecting said transducer with said generator unit and generator output electrodes for implantation in the muscle tissue, said capsule comprising a mass consisting of medical grade silicone rubber and a natural wax.

5. The invention of claim 4 in which said encapsulation consists of an inner core of natural wax enclosing said generator,

transducer and input electrodes, and an outer relatively thin interface of medical grade silicone rubber completely enclos ing the core. 5

Claims (4)

  1. 2. The invention as defined in claim 1 in which said envelope comprises a natural wax inner enclosure for the generator and the transdUcer and a medical grade silicone rubber, outer, living tissue compatible envelope.
  2. 3. The invention defined in claim 1 in which the material forming the capsule consists of a natural wax and medical grade silicone rubber intimately and uniformly dispersed throughout the total mass to form an envelope.
  3. 4. An encapsulated pacesetter comprising an elongate capsule enclosing a piezoelectric generator unit at one end of the capsule, a transducer unit enclosed in the capsule and extending in a direction from said capsule end enclosing said generator to provide a flat flexing portion responsive to movement of organic muscle tissue in which the device is implanted in close proximity thereto, input electrodes within the capsule electrically connecting said transducer with said generator unit and generator output electrodes for implantation in the muscle tissue, said capsule comprising a mass consisting of medical grade silicone rubber and a natural wax.
  4. 5. The invention of claim 4 in which said encapsulation consists of an inner core of natural wax enclosing said generator, transducer and input electrodes, and an outer relatively thin interface of medical grade silicone rubber completely enclosing the core.
US3659615A 1970-06-08 1970-06-08 Encapsulated non-permeable piezoelectric powered pacesetter Expired - Lifetime US3659615A (en)

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Cited By (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941137A (en) * 1971-02-27 1976-03-02 U.S. Philips Corporation Ambulatory stimulator
US4333469A (en) * 1979-07-20 1982-06-08 Telectronics Pty. Ltd. Bone growth stimulator
US4485268A (en) * 1983-06-13 1984-11-27 Minnesota Mining And Manufacturing Sealing device for an electrical connector and method therefor
US4485813A (en) * 1981-11-19 1984-12-04 Medtronic, Inc. Implantable dynamic pressure transducer system
US4545380A (en) * 1984-04-16 1985-10-08 Cordis Corporation Method and apparatus for setting and changing parameters or functions of an implanted device
US4763646A (en) * 1985-10-04 1988-08-16 Siemens Aktiengesellschaft Heart pacemaker
DE3709022A1 (en) * 1987-03-19 1988-09-29 Alt Eckhard Frequency-variable pacemaker
US4793825A (en) * 1984-09-11 1988-12-27 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom And Northern Ireland Active silicon implant devices
US4940053A (en) * 1989-01-25 1990-07-10 Siemens-Pacesetter, Inc. Energy controlled rate-responsive pacemaker having automatically adjustable control parameters
US4940052A (en) * 1989-01-25 1990-07-10 Siemens-Pacesetter, Inc. Microprocessor controlled rate-responsive pacemaker having automatic rate response threshold adjustment
US5040535A (en) * 1989-01-25 1991-08-20 Siemens-Pacesetter, Inc. Average amplitude controlled rate-responsive pacemaker having automatically adjustable control parameters
US5040534A (en) * 1989-01-25 1991-08-20 Siemens-Pacesetter, Inc. Microprocessor controlled rate-responsive pacemaker having automatic rate response threshold adjustment
US5332944A (en) * 1993-10-06 1994-07-26 Cline David J Environmentally sealed piezoelectric switch assembly
DE4330680A1 (en) * 1993-09-10 1995-03-16 Michael Dr Zwicker Device for electrical stimulation of cells within a living human or animal
US5431694A (en) * 1992-08-18 1995-07-11 Snaper; Alvin A. Bio-operable power source
US5749909A (en) * 1996-11-07 1998-05-12 Sulzer Intermedics Inc. Transcutaneous energy coupling using piezoelectric device
US5810015A (en) * 1995-09-01 1998-09-22 Strato/Infusaid, Inc. Power supply for implantable device
US5876424A (en) * 1997-01-23 1999-03-02 Cardiac Pacemakers, Inc. Ultra-thin hermetic enclosure for implantable medical devices
US5883459A (en) * 1997-07-21 1999-03-16 Balboa Instruments Inc. Electrical switch assembly encapsulated against moisture intrusion
US5894651A (en) * 1990-10-29 1999-04-20 Trw Inc. Method for encapsulating a ceramic device for embedding in composite structures
US6016020A (en) * 1997-09-03 2000-01-18 Balboa Instruments, Inc. Method and apparatus using low voltage level actuator to control operation of electrical appliance
US6187028B1 (en) 1998-04-23 2001-02-13 Intermedics Inc. Capacitors having metallized film with tapered thickness
US6249423B1 (en) 1998-04-21 2001-06-19 Cardiac Pacemakers, Inc. Electrolytic capacitor and multi-anodic attachment
US6275729B1 (en) 1998-10-02 2001-08-14 Cardiac Pacemakers, Inc. Smaller electrolytic capacitors for implantable defibrillators
US6385490B1 (en) 1999-12-16 2002-05-07 Cardiac Pacemakers, Inc. Capacitors with recessed rivets allow smaller implantable defibrillators
US6421226B1 (en) 1998-10-02 2002-07-16 Cardiac Pacemakes, Inc. High-energy capacitors for implantable defibrillators
US6426864B1 (en) 2000-06-29 2002-07-30 Cardiac Pacemakers, Inc. High energy capacitors for implantable defibrillators
US20020120295A1 (en) * 2001-02-27 2002-08-29 Olson Renee C. Battery-less, human-powered electrotherapy device and method of use
US20030168861A1 (en) * 2002-02-28 2003-09-11 Estevez Leonardo W. Generating electric power in response to activity of a biological system
US6654638B1 (en) * 2000-04-06 2003-11-25 Cardiac Pacemakers, Inc. Ultrasonically activated electrodes
US20040021322A1 (en) * 2002-07-31 2004-02-05 Arie Ariav Method and apparatus for body generation of electrical energy
US20050256549A1 (en) * 2002-10-09 2005-11-17 Sirius Implantable Systems Ltd. Micro-generator implant
US20060034943A1 (en) * 2003-10-31 2006-02-16 Technology Innovations Llc Process for treating a biological organism
US20060061938A1 (en) * 2004-07-16 2006-03-23 Cardiac Pacemakers, Inc. Method and apparatus for insulative film for capacitor components
US20060136005A1 (en) * 2004-12-21 2006-06-22 Ebr Systems, Inc. Implantable transducer devices
US20060136004A1 (en) * 2004-12-21 2006-06-22 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US20060147371A1 (en) * 2003-10-31 2006-07-06 Tuszynski Jack A Water-soluble compound
US20060175939A1 (en) * 2003-07-10 2006-08-10 Kazuo Murata Piezoelectric device and method of producing the same
US20060217776A1 (en) * 2005-03-25 2006-09-28 Robert White Implantable cardiac motion powered piezoelectric energy source
US20070060961A1 (en) * 2005-09-12 2007-03-15 Ebr Systems, Inc. Methods and apparatus for determining cardiac stimulation sites using hemodynamic data
US20070078490A1 (en) * 2004-12-21 2007-04-05 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US20070088402A1 (en) * 2005-10-18 2007-04-19 Melvin David B Muscle energy converter with smooth continuous tissue interface
US20080294208A1 (en) * 2007-05-23 2008-11-27 Ebr Systems, Inc. Optimizing energy transmission in a leadless tissue stimulation system
US20090152990A1 (en) * 2007-12-07 2009-06-18 Veryst Engineering Llc Apparatus for in vivo energy harvesting
WO2009120785A2 (en) 2008-03-25 2009-10-01 Ebr Systems, Inc. Implantable wireless acoustic stimulators with high energy conversion efficiencies
WO2010005915A2 (en) * 2008-07-06 2010-01-14 Synecor Llc Energy harvesting for implanted medical devices
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US20100140957A1 (en) * 2008-12-04 2010-06-10 Searete Llc Method for generation of power from intraluminal pressure changes
US20100140956A1 (en) * 2008-12-04 2010-06-10 Searete Llc. Method for generation of power from intraluminal pressure changes
US20100140958A1 (en) * 2008-12-04 2010-06-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for powering devices from intraluminal pressure changes
WO2010070650A1 (en) 2008-12-21 2010-06-24 Sirius Implantable Systems Ltd. High efficiency piezoelectric micro-generator and energy storage system
US20100160994A1 (en) * 2007-01-04 2010-06-24 Board Of Regents, The University Of Texas System Cardiovascular power source for automatic implantable cardioverter defibrillators
US20100179628A1 (en) * 2002-08-19 2010-07-15 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University Neurostimulator
US7765001B2 (en) 2005-08-31 2010-07-27 Ebr Systems, Inc. Methods and systems for heart failure prevention and treatments using ultrasound and leadless implantable devices
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
US20100217354A1 (en) * 2009-02-20 2010-08-26 Biotronik Crm Patent Ag Active Medical Implant
US20100234924A1 (en) * 2008-03-25 2010-09-16 Ebr Systems, Inc. Operation and estimation of output voltage of wireless stimulators
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US20100317977A1 (en) * 2009-06-10 2010-12-16 Piaget Thomas W Implantable medical device with internal piezoelectric energy harvesting
US20100317978A1 (en) * 2009-06-10 2010-12-16 Maile Keith R Implantable medical device housing modified for piezoelectric energy harvesting
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US7953493B2 (en) 2007-12-27 2011-05-31 Ebr Systems, Inc. Optimizing size of implantable medical devices by isolating the power source
US8016745B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. Monitoring of a food intake restriction device
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US20110237967A1 (en) * 2008-03-25 2011-09-29 Ebr Systems, Inc. Temporary electrode connection for wireless pacing systems
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
WO2012020034A1 (en) 2010-08-09 2012-02-16 Pi-Harvest Holding Ag Medical system, piezoelectric kit, related methods and medical procedures
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US9180285B2 (en) 2008-03-25 2015-11-10 Ebr Systems, Inc. Implantable wireless accoustic stimulators with high energy conversion efficiencies
US9289612B1 (en) 2014-12-11 2016-03-22 Medtronic Inc. Coordination of ventricular pacing in a leadless pacing system
US9353733B2 (en) 2008-12-04 2016-05-31 Deep Science, Llc Device and system for generation of power from intraluminal pressure changes
US9399140B2 (en) 2014-07-25 2016-07-26 Medtronic, Inc. Atrial contraction detection by a ventricular leadless pacing device for atrio-synchronous ventricular pacing
US9492668B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9492669B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9526418B2 (en) 2008-12-04 2016-12-27 Deep Science, Llc Device for storage of intraluminally generated power
US9623234B2 (en) 2014-11-11 2017-04-18 Medtronic, Inc. Leadless pacing device implantation
US9631610B2 (en) 2008-12-04 2017-04-25 Deep Science, Llc System for powering devices from intraluminal pressure changes
US9724519B2 (en) 2014-11-11 2017-08-08 Medtronic, Inc. Ventricular leadless pacing device mode switching
US9731139B2 (en) 2008-07-16 2017-08-15 Ebr Systems, Inc. Local lead to improve energy efficiency in implantable wireless acoustic stimulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3456134A (en) * 1967-10-05 1969-07-15 Us Health Education & Welfare Piezoelectric energy converter for electronic implants
US3486506A (en) * 1965-10-13 1969-12-30 Philips Corp Heart-actuated,spring driven cardiac stimulator

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3486506A (en) * 1965-10-13 1969-12-30 Philips Corp Heart-actuated,spring driven cardiac stimulator
US3456134A (en) * 1967-10-05 1969-07-15 Us Health Education & Welfare Piezoelectric energy converter for electronic implants

Cited By (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3941137A (en) * 1971-02-27 1976-03-02 U.S. Philips Corporation Ambulatory stimulator
US4333469A (en) * 1979-07-20 1982-06-08 Telectronics Pty. Ltd. Bone growth stimulator
US4485813A (en) * 1981-11-19 1984-12-04 Medtronic, Inc. Implantable dynamic pressure transducer system
US4485268A (en) * 1983-06-13 1984-11-27 Minnesota Mining And Manufacturing Sealing device for an electrical connector and method therefor
US4545380A (en) * 1984-04-16 1985-10-08 Cordis Corporation Method and apparatus for setting and changing parameters or functions of an implanted device
US4793825A (en) * 1984-09-11 1988-12-27 The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom And Northern Ireland Active silicon implant devices
US4763646A (en) * 1985-10-04 1988-08-16 Siemens Aktiengesellschaft Heart pacemaker
DE3709022A1 (en) * 1987-03-19 1988-09-29 Alt Eckhard Frequency-variable pacemaker
US4940053A (en) * 1989-01-25 1990-07-10 Siemens-Pacesetter, Inc. Energy controlled rate-responsive pacemaker having automatically adjustable control parameters
US4940052A (en) * 1989-01-25 1990-07-10 Siemens-Pacesetter, Inc. Microprocessor controlled rate-responsive pacemaker having automatic rate response threshold adjustment
US5040535A (en) * 1989-01-25 1991-08-20 Siemens-Pacesetter, Inc. Average amplitude controlled rate-responsive pacemaker having automatically adjustable control parameters
US5040534A (en) * 1989-01-25 1991-08-20 Siemens-Pacesetter, Inc. Microprocessor controlled rate-responsive pacemaker having automatic rate response threshold adjustment
US5894651A (en) * 1990-10-29 1999-04-20 Trw Inc. Method for encapsulating a ceramic device for embedding in composite structures
US5431694A (en) * 1992-08-18 1995-07-11 Snaper; Alvin A. Bio-operable power source
DE4330680A1 (en) * 1993-09-10 1995-03-16 Michael Dr Zwicker Device for electrical stimulation of cells within a living human or animal
US5332944A (en) * 1993-10-06 1994-07-26 Cline David J Environmentally sealed piezoelectric switch assembly
US5810015A (en) * 1995-09-01 1998-09-22 Strato/Infusaid, Inc. Power supply for implantable device
US5749909A (en) * 1996-11-07 1998-05-12 Sulzer Intermedics Inc. Transcutaneous energy coupling using piezoelectric device
US5876424A (en) * 1997-01-23 1999-03-02 Cardiac Pacemakers, Inc. Ultra-thin hermetic enclosure for implantable medical devices
US5883459A (en) * 1997-07-21 1999-03-16 Balboa Instruments Inc. Electrical switch assembly encapsulated against moisture intrusion
US6016020A (en) * 1997-09-03 2000-01-18 Balboa Instruments, Inc. Method and apparatus using low voltage level actuator to control operation of electrical appliance
US6881232B2 (en) 1998-04-21 2005-04-19 Cardiac Pacemakers, Inc. Electrolytic capacitor and multi-anodic attachment
US6249423B1 (en) 1998-04-21 2001-06-19 Cardiac Pacemakers, Inc. Electrolytic capacitor and multi-anodic attachment
US20040105212A1 (en) * 1998-04-21 2004-06-03 Cardiac Pacemakers, Inc. Electrolytic capacitor and multi-anodic attachment
US6597564B2 (en) 1998-04-21 2003-07-22 Cardiac Pacemakers, Inc. Electrolytic capacitor and multi-anodic attachment
US6187028B1 (en) 1998-04-23 2001-02-13 Intermedics Inc. Capacitors having metallized film with tapered thickness
US6514276B2 (en) 1998-04-23 2003-02-04 Intermedics, Inc. Metallized film capacitor for use in implantable defibrillator
US20090269610A1 (en) * 1998-10-02 2009-10-29 O'phelan Michael J High-energy capacitors for implantable defibrillators
US20050237697A1 (en) * 1998-10-02 2005-10-27 Cardiac Pacemakers, Inc. Smaller electrolytic capacitors for implantable defibrillators
US6535374B2 (en) 1998-10-02 2003-03-18 Cardiac Pacemakers, Inc. Smaller electrolytic capacitors for implantable defibrillators
US7251123B2 (en) 1998-10-02 2007-07-31 Cardiac Pacemakers, Inc. Smaller electrolytic capacitors for implantable defibrillators
US6556863B1 (en) 1998-10-02 2003-04-29 Cardiac Pacemakers, Inc. High-energy capacitors for implantable defibrillators
US6421226B1 (en) 1998-10-02 2002-07-16 Cardiac Pacemakes, Inc. High-energy capacitors for implantable defibrillators
US20060256505A1 (en) * 1998-10-02 2006-11-16 Cardiac Pacemakers, Inc. High-energy capacitors for implantable defibrillators
US6839224B2 (en) 1998-10-02 2005-01-04 Cardiac Pacemakers, Inc. Smaller electrolytic capacitors for implantable defibrillators
US20030223178A1 (en) * 1998-10-02 2003-12-04 Cardiac Pacemakers, Inc. Smaller electrolytic capacitors for implantable defibrillators
US7558051B2 (en) 1998-10-02 2009-07-07 Cardiac Pacemakers, Inc. High-energy capacitors for implantable defibrillators
US20040039421A1 (en) * 1998-10-02 2004-02-26 Cardiac Pacemakers, Inc. High-energy electrolytic capacitors for implantable defibrillators
US7043300B2 (en) 1998-10-02 2006-05-09 Cardiac Pacemakers, Inc. High-energy electrolytic capacitors for implantable defibrillators
US6275729B1 (en) 1998-10-02 2001-08-14 Cardiac Pacemakers, Inc. Smaller electrolytic capacitors for implantable defibrillators
US6385490B1 (en) 1999-12-16 2002-05-07 Cardiac Pacemakers, Inc. Capacitors with recessed rivets allow smaller implantable defibrillators
US6853538B2 (en) 1999-12-16 2005-02-08 Cardiac Pacemakers, Inc. Capacitors with recessed rivets allow smaller implantable defibrillators
US6654638B1 (en) * 2000-04-06 2003-11-25 Cardiac Pacemakers, Inc. Ultrasonically activated electrodes
US6426864B1 (en) 2000-06-29 2002-07-30 Cardiac Pacemakers, Inc. High energy capacitors for implantable defibrillators
US6546286B2 (en) * 2001-02-27 2003-04-08 Koninklijke Philips Electronics N.V. Battery-less, human-powered electrotherapy device
US20020120295A1 (en) * 2001-02-27 2002-08-29 Olson Renee C. Battery-less, human-powered electrotherapy device and method of use
US6822343B2 (en) 2002-02-28 2004-11-23 Texas Instruments Incorporated Generating electric power in response to activity of a biological system
US20030168861A1 (en) * 2002-02-28 2003-09-11 Estevez Leonardo W. Generating electric power in response to activity of a biological system
US20040021322A1 (en) * 2002-07-31 2004-02-05 Arie Ariav Method and apparatus for body generation of electrical energy
US7081683B2 (en) * 2002-07-31 2006-07-25 Arie Ariav Method and apparatus for body generation of electrical energy
US9457196B2 (en) 2002-08-19 2016-10-04 Arizona Board Of Regents On Behalf Of Arizona State University Neurostimulator
US8369956B2 (en) 2002-08-19 2013-02-05 Arizona Board Of Regents, A Body Corporate, Acting For And On Behalf Of Arizona State University Neurostimulator
US20100179628A1 (en) * 2002-08-19 2010-07-15 Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University Neurostimulator
US20110077722A1 (en) * 2002-08-19 2011-03-31 Arizona Board of Regents, a body corporate acting and on behalf of Arizona State University Neurostimulator
US8626303B2 (en) 2002-08-19 2014-01-07 Arizona Board Of Regents, A Body Corporate, Acting For And On Behalf Of Arizona State University Neurostimulator
US8774928B2 (en) 2002-08-19 2014-07-08 Arizona Board of Regents on Behalf Arizona State University Neurostimulator
US8340773B2 (en) * 2002-08-19 2012-12-25 Arizona Board Of Regents, A Body Corporate, Acting For And On Behalf Of Arizona State University Neurostimulator
US9555258B2 (en) 2002-08-19 2017-01-31 Arizona Board Of Regents On Behalf Of Arizona State Unveristy Neurostimulator
US20050256549A1 (en) * 2002-10-09 2005-11-17 Sirius Implantable Systems Ltd. Micro-generator implant
US20060175939A1 (en) * 2003-07-10 2006-08-10 Kazuo Murata Piezoelectric device and method of producing the same
US20060147371A1 (en) * 2003-10-31 2006-07-06 Tuszynski Jack A Water-soluble compound
US20060034943A1 (en) * 2003-10-31 2006-02-16 Technology Innovations Llc Process for treating a biological organism
US20100286744A1 (en) * 2004-06-15 2010-11-11 Ebr Systems, Inc. Methods and systems for heart failure treatments using ultrasound and leadless implantable devices
US9333364B2 (en) 2004-06-15 2016-05-10 Ebr Systems, Inc. Methods and systems for heart failure treatments using ultrasound and leadless implantable devices
US7426104B2 (en) 2004-07-16 2008-09-16 Cardiac Pacemakers, Inc. Method and apparatus for insulative film for capacitor components
US20060061938A1 (en) * 2004-07-16 2006-03-23 Cardiac Pacemakers, Inc. Method and apparatus for insulative film for capacitor components
US7610092B2 (en) 2004-12-21 2009-10-27 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US7606621B2 (en) 2004-12-21 2009-10-20 Ebr Systems, Inc. Implantable transducer devices
US20100228308A1 (en) * 2004-12-21 2010-09-09 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US7558631B2 (en) 2004-12-21 2009-07-07 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US20090326601A1 (en) * 2004-12-21 2009-12-31 Ebr Systems, Inc. Implantable transducer devices
US9008776B2 (en) 2004-12-21 2015-04-14 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US7848815B2 (en) 2004-12-21 2010-12-07 Ebr Systems, Inc. Implantable transducer devices
US20100063562A1 (en) * 2004-12-21 2010-03-11 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US20060136004A1 (en) * 2004-12-21 2006-06-22 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US8315701B2 (en) 2004-12-21 2012-11-20 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US7890173B2 (en) 2004-12-21 2011-02-15 Ebr Systems, Inc. Implantable transducer devices
US20060136005A1 (en) * 2004-12-21 2006-06-22 Ebr Systems, Inc. Implantable transducer devices
US7996087B2 (en) 2004-12-21 2011-08-09 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US20070078490A1 (en) * 2004-12-21 2007-04-05 Ebr Systems, Inc. Leadless tissue stimulation systems and methods
US8016745B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. Monitoring of a food intake restriction device
US7927270B2 (en) 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US20100228312A1 (en) * 2005-03-25 2010-09-09 Robert White Implantable Cardiac Motion Powered Piezoelectric Energy Source
US20060217776A1 (en) * 2005-03-25 2006-09-28 Robert White Implantable cardiac motion powered piezoelectric energy source
US7729768B2 (en) * 2005-03-25 2010-06-01 Proteus Biomedical, Inc. Implantable cardiac motion powered piezoelectric energy source
US20090000090A1 (en) * 2005-05-09 2009-01-01 Cardiac Pacemakers, Inc. Method for insulative film for capacitor components
US7699899B2 (en) 2005-05-09 2010-04-20 Cardiac Pacemakers, Inc. Method for insulative film for capacitor components
US7765001B2 (en) 2005-08-31 2010-07-27 Ebr Systems, Inc. Methods and systems for heart failure prevention and treatments using ultrasound and leadless implantable devices
US7702392B2 (en) 2005-09-12 2010-04-20 Ebr Systems, Inc. Methods and apparatus for determining cardiac stimulation sites using hemodynamic data
US20070060961A1 (en) * 2005-09-12 2007-03-15 Ebr Systems, Inc. Methods and apparatus for determining cardiac stimulation sites using hemodynamic data
US20070088402A1 (en) * 2005-10-18 2007-04-19 Melvin David B Muscle energy converter with smooth continuous tissue interface
US7715918B2 (en) * 2005-10-18 2010-05-11 University Of Cincinnati Muscle energy converter with smooth continuous tissue interface
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US8152710B2 (en) 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
WO2008039619A2 (en) 2006-09-27 2008-04-03 Ebr Systems, Inc. Temporary leadless pacing systems and methods
US20100160994A1 (en) * 2007-01-04 2010-06-24 Board Of Regents, The University Of Texas System Cardiovascular power source for automatic implantable cardioverter defibrillators
US8718773B2 (en) 2007-05-23 2014-05-06 Ebr Systems, Inc. Optimizing energy transmission in a leadless tissue stimulation system
US20080294208A1 (en) * 2007-05-23 2008-11-27 Ebr Systems, Inc. Optimizing energy transmission in a leadless tissue stimulation system
US20090152990A1 (en) * 2007-12-07 2009-06-18 Veryst Engineering Llc Apparatus for in vivo energy harvesting
US8217523B2 (en) * 2007-12-07 2012-07-10 Veryst Engineering Llc Apparatus for in vivo energy harvesting
US8187163B2 (en) 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US8142452B2 (en) 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US7953493B2 (en) 2007-12-27 2011-05-31 Ebr Systems, Inc. Optimizing size of implantable medical devices by isolating the power source
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US8221439B2 (en) 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US8114345B2 (en) 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8057492B2 (en) 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8034065B2 (en) 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
US8187162B2 (en) 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US9180285B2 (en) 2008-03-25 2015-11-10 Ebr Systems, Inc. Implantable wireless accoustic stimulators with high energy conversion efficiencies
US9981138B2 (en) 2008-03-25 2018-05-29 Ebr Systems, Inc. Operation and estimation of output voltage of wireless stimulators
EP2452721A1 (en) 2008-03-25 2012-05-16 EBR Systems, Inc. Method of manufacturing implantable wireless acoustic stimulators with high energy conversion efficiencies
US20110237967A1 (en) * 2008-03-25 2011-09-29 Ebr Systems, Inc. Temporary electrode connection for wireless pacing systems
US9283392B2 (en) 2008-03-25 2016-03-15 Ebr Systems, Inc. Temporary electrode connection for wireless pacing systems
US8364276B2 (en) 2008-03-25 2013-01-29 Ebr Systems, Inc. Operation and estimation of output voltage of wireless stimulators
US9907968B2 (en) 2008-03-25 2018-03-06 Ebr Systems, Inc. Temporary electrode connection for wireless pacing systems
US20100234924A1 (en) * 2008-03-25 2010-09-16 Ebr Systems, Inc. Operation and estimation of output voltage of wireless stimulators
WO2009120785A2 (en) 2008-03-25 2009-10-01 Ebr Systems, Inc. Implantable wireless acoustic stimulators with high energy conversion efficiencies
US9343654B2 (en) 2008-03-25 2016-05-17 Ebr Systems, Inc. Method of manufacturing implantable wireless acoustic stimulators with high energy conversion efficiencies
WO2010005915A3 (en) * 2008-07-06 2010-04-01 Synecor Llc Energy harvesting for implanted medical devices
WO2010005915A2 (en) * 2008-07-06 2010-01-14 Synecor Llc Energy harvesting for implanted medical devices
US9731139B2 (en) 2008-07-16 2017-08-15 Ebr Systems, Inc. Local lead to improve energy efficiency in implantable wireless acoustic stimulators
US9526418B2 (en) 2008-12-04 2016-12-27 Deep Science, Llc Device for storage of intraluminally generated power
US9759202B2 (en) 2008-12-04 2017-09-12 Deep Science, Llc Method for generation of power from intraluminal pressure changes
US20100140956A1 (en) * 2008-12-04 2010-06-10 Searete Llc. Method for generation of power from intraluminal pressure changes
US9631610B2 (en) 2008-12-04 2017-04-25 Deep Science, Llc System for powering devices from intraluminal pressure changes
US20100140957A1 (en) * 2008-12-04 2010-06-10 Searete Llc Method for generation of power from intraluminal pressure changes
US9567983B2 (en) 2008-12-04 2017-02-14 Deep Science, Llc Method for generation of power from intraluminal pressure changes
US9353733B2 (en) 2008-12-04 2016-05-31 Deep Science, Llc Device and system for generation of power from intraluminal pressure changes
US20100140958A1 (en) * 2008-12-04 2010-06-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for powering devices from intraluminal pressure changes
WO2010070650A1 (en) 2008-12-21 2010-06-24 Sirius Implantable Systems Ltd. High efficiency piezoelectric micro-generator and energy storage system
US20100217354A1 (en) * 2009-02-20 2010-08-26 Biotronik Crm Patent Ag Active Medical Implant
US8401647B2 (en) * 2009-02-20 2013-03-19 Biotronik Crm Patent Ag Active medical implant
US8777863B2 (en) * 2009-06-10 2014-07-15 Cardiac Pacemakers, Inc. Implantable medical device with internal piezoelectric energy harvesting
US20100317978A1 (en) * 2009-06-10 2010-12-16 Maile Keith R Implantable medical device housing modified for piezoelectric energy harvesting
US20100317977A1 (en) * 2009-06-10 2010-12-16 Piaget Thomas W Implantable medical device with internal piezoelectric energy harvesting
WO2012020034A1 (en) 2010-08-09 2012-02-16 Pi-Harvest Holding Ag Medical system, piezoelectric kit, related methods and medical procedures
US9399140B2 (en) 2014-07-25 2016-07-26 Medtronic, Inc. Atrial contraction detection by a ventricular leadless pacing device for atrio-synchronous ventricular pacing
US9492668B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9724519B2 (en) 2014-11-11 2017-08-08 Medtronic, Inc. Ventricular leadless pacing device mode switching
US9492669B2 (en) 2014-11-11 2016-11-15 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9808628B2 (en) 2014-11-11 2017-11-07 Medtronic, Inc. Mode switching by a ventricular leadless pacing device
US9623234B2 (en) 2014-11-11 2017-04-18 Medtronic, Inc. Leadless pacing device implantation
US9289612B1 (en) 2014-12-11 2016-03-22 Medtronic Inc. Coordination of ventricular pacing in a leadless pacing system

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