US3655306A - Apparatus for molding heart valves - Google Patents
Apparatus for molding heart valves Download PDFInfo
- Publication number
- US3655306A US3655306A US3749A US3655306DA US3655306A US 3655306 A US3655306 A US 3655306A US 3749 A US3749 A US 3749A US 3655306D A US3655306D A US 3655306DA US 3655306 A US3655306 A US 3655306A
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- forming members
- tissue
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- Expired - Lifetime
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- 210000003709 heart valve Anatomy 0.000 title claims abstract description 18
- 238000000465 moulding Methods 0.000 title description 3
- 238000004519 manufacturing process Methods 0.000 claims abstract description 8
- 230000000295 complement effect Effects 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 229920003023 plastic Polymers 0.000 claims description 4
- 239000013536 elastomeric material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 9
- 210000000689 upper leg Anatomy 0.000 abstract description 3
- 210000001765 aortic valve Anatomy 0.000 description 5
- 229920002379 silicone rubber Polymers 0.000 description 3
- 239000004945 silicone rubber Substances 0.000 description 3
- 238000004026 adhesive bonding Methods 0.000 description 2
- 229920004934 Dacron® Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/901—Method of manufacturing prosthetic device
Definitions
- the present invention relates to surgical apparatus and method.
- a technique for manufacturing a replacement heart valve using tissue taken from the thigh region of a patient undergoing treatment Because the patient's own tissue is used, this so-called autograft technique avoids the serious problems of degeneration and calcification associated with the so-called homograft technique in which a faulty heart valve is replaced by a similar valve taken from a cadaver.
- the manufacture of the replacement valve requires the tissue to be cut and shaped into the form of the cusps of the valve by the surgeon performing the operation. This is a time-consuming process and demands a high standard of competence on the part of the surgeon.
- FIG. 1 is a representation of one embodiment of the invention mounted in a frame
- FIG. 2 shows a perspective view of the co-operating surfaces of formers according to one embodiment
- FIG. 3 shows in perspective a second embodiment of one former
- FIG. 4 shows a support for use with the embodiments shown in FIGS. 2 and 3.
- a male former 11 and a female former 12 have complementary surfaces 13 and 14 respectively, which are so shaped as to conform to the configurations of the three cusps of an aortic valve.
- the formers 11 and 12 are cylindrical and have respective recesses 15 and 16 in their bases into which fit locating pegs l7 and 18 that form part of a frame 19.
- the peg 17 is in the form of a spring-loaded plunger to facilitate the insertion of the formers 11 and 12 into the frame 19.
- the peg 17 is also arranged to be adjustable, so that the spring pressure can be varied and thus provides varying pressure on the tissue.
- the frame 19 is mounted upon a stand 20 by means of a universal joint 21.
- the shapes of the co-operating surfaces 13 and 14 are determined by taking a cast of an aortic valve and transferring the configuration of the cast to the female former 12.
- the former 12 is then used to cast a male reproduction 22 in a silicone rubber, which is mounted on a poly methyl methacrylate cylinder 23 to form the male former 11.
- the male former 11 is made in this fashion so that the silicone rubber would act as a cushion and reduce the possibility of damage to tissue placed between the male and female formers.
- a support 24 is used to maintain the tissue in the shape formed by the formers 11 and 12 when the tissue is placed therebetween.
- the support 24, which conforms accurately to the shape of the cusps of the aortic valve, is made of the plastics material known as polypropylene and is covered by biologically compatible woven or knitted plastics material such as Dacron or Teflon.
- the male former 11 includes a base 37 from which depend three finger-like members, 38, 39 and 40.
- the free ends of the members each include a pad 31, 32 and 33 respectively.
- the pads may be made from silicone rubber.
- the member 38 is integral with the base 37.
- the members 39 and 40 are removable from the base 37, a spring clip 34 and 35 pivoted to the base 37 securing the respective member in seatings (not shown) in the base.
- the base 37 also includes a recess 15.
- the former 12 is used to cast and mould to the required shape the pads 31, 32 and 33.
- the members 38, 39 and 40 and base 37 of the former 11 may suitably be of stainless steel.
- the support 24 which is to form part of a valve to be made, is placed in position on the female former 12 with projections 24' coincident with the ridges 14'.
- Suitable pieces of tissue (not shown) taken for example from the thigh of a patient being operated upon, is then placed between the formers 11 and 12.
- the formers 11 and 12 are then held together and mounted in the frame 19 by means of the pegs 17 and 18.
- the exposed edges of the tissue are then attached to the support 24 using standard surgical sutures or careful glueing or stapling and trimmed with scissors.
- the tissue is attached along the curves of the support, conforming to the shape of the valve. This operation is facilitated by the universal joint 21.
- the formers 11 and 12 are then removed from the frame 19 and separated and the tissue is cut along the lines where the valve cusps meet, again with the aid of scissors.
- the support 24 is placed in position on the former 12 with fingers 24' coincident with ridges 14 as previously described.
- the curved surfaces in the support 24 then correspond with the curved edges on the former 12.
- the former is then mounted on the frame 19, the peg 18 on I the frame entering the recess 16.
- the former 11' with members 39 and 40 removed, is then mounted on the frame, the peg 17 which is spring mounted, entering the recess 15.
- a single piece of autogenous tissue having one straight edge is then wrapped around the former 12 and then held in position between the pad 31 on the fixed member 38 and one cusp 14 of the former 12.
- the tissue is then folded into a second cusp and the demountable member 39 is secured in position in the base 37, the spring clip 34 being pivoted downwardly to engage the member 39 and hold it securely in position.
- the tissue is then securely held between the second cusp 4 and the pad 32 as well as between the first cusp and the pad 31.
- the same procedure is used with respect to the other member 40.
- the tissue is thus moulded into the form of a tri-cuspic aortic valve.
- the edges of the tissue are then attached as before to the support 17 using standard surgical sutures or careful stap
- a tri-cuspic heart valve is obtained using autogenous fresh tissue, and can be placed in a defective heart.
- both embodiments of the invention provide a process which can be carried out quickly and simply by unskilled personnel.
- the aortic valve produced in the process and apparatus of the invention can be manufactured in the operating theatre while the surgeon is engaged in the early stages of an operation. This enables the surgeon and his assistant to concentrate on the operation and removes the onus of manufacturing the replacement from them, shortens the operation and reduces the risk of infection.
- An apparatus for manufacturing a replacement heart valve comprising tissue taken from a patient, and further comprising forming means including first and second forming members having first and second complementary surfaces, respectively, the first surface being defined by a plurality of projections which conform to the configuration of the cusps of a heart valve, and the second surface being defined by a plurality of recesses which also conform to the configuration of the cusps of a heart valve.
- An apparatus including mounting means mounting said first and second forming members for relative linear movement toward and away from each other.
- mounting means includes spring means for resiliently urging the first and second forming members in a direction toward each other.
- An apparatus including stationary support means, frame means rotatably mounted on said support means, means coacting with said frame means and said support means for selectively fixedly securing said frame means in a selected position relative to said support means, and means mounting said first and second forming members on said frame means for permitting relative linear movement of said forming members toward and away from each other.
- said frame means includes a substantially U-shaped member rotatably mounted on said support means for rotation about a substantially horizontal axis, and said first and second forming members being mounted on said U-shaped member substantially adjacent the free ends of the legs thereof for relative linear movement in a direction substantially transverse to said horizontal axis.
- An apparatus further including spring means coacting between said U-shaped member and one of said forming members for resiliently urging said one forming member into engagement with said other forming member.
- first and second forming members are cylindrical, and wherein the projections formed on said first forming member are constructed of an elastomeric material so as to act as a cushion when the forming members are positioned in engagement with one another so as to not damage the tissue placed therebetween.
- An apparatus further including a sleeve-like support member positioned in surrounding relationship to said forming members, said support member having projections adjacent one end thereof having a configuration conforming to the shape of the cusps of the heart valve and being made of a plastics material for permitting the edges of the tissue, when positioned between the forming members, to be sewn thereto.
- two of said finger-like members include means whereby the two fingerlike members are demountable from said one forming member.
- the fingerlike members each include a pad at one extremity, which pads conform to the configuration of said recesses.
- the plurality of projections comprise three finger-like members spaced equidistantly around the periphery of one of said forming members, two of said two demountable dismantled from said one forming member.
- said one forming member includes securing means mounted on said forming member coactig with said two demountable members for securing said finger-like members in said one forming member when inserted in said one forming member.
- said securing means comprise spring means rotatably mounted on said one former member for coacting with respective stem means of said two finger-like members.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Manufacturing & Machinery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Abstract
The invention relates to an apparatus and method for manufacturing replacement aortic heart valves using tissue taken from a patient''s own thigh. The tissue is moulded between first and second complementary surfaces of two complementary forming members, the complementary surfaces corresponding to the configuration of the heart valve. The tissue when moulded is secured to a support.
Description
aet
oss et a1.
1151 3,655,306 [451 Apr.11,1972
APPARATUS F OR MOLDING HEART VALVES Inventors: Donald Nixon Ross; Derek Barrie Ray, both of National Heart Hospital West Moreland Street, London W. 1 England Filed: Jan. 19, 1970 Appl. No.: 3,749
US. Cl. ..425/l09, 3/DlG. 3, 425/2, 3/ 1 .2, 128/1 Int. Cl. ..A6lf l/22, 829d 31/00 Fieldofsearch ..3/l l-lV,DlG. 3; l37/525.1; 18/5 R, 5.1, l R, 16 R, 34 R, 22, 47 R References Cited UNITED STATES PATENTS 5/1967 High et al ..3/DIG. 3
3,466,671 9/1969 Siposs ..3/DlG.3 3,564,617 2/1971 Sauvageetal. ..3/DlG.3
Primary Examiner-Robert L. Spicer, Jr. Attorney-Woodhams, Blanchard and Flynn [5 7] ABSTRACT 14 Claims, 4 Drawing Figures AFPARATUS FOR MOLDING HEART VALVES The present invention relates to surgical apparatus and method.
A technique has been developed for manufacturing a replacement heart valve using tissue taken from the thigh region of a patient undergoing treatment. Because the patient's own tissue is used, this so-called autograft technique avoids the serious problems of degeneration and calcification associated with the so-called homograft technique in which a faulty heart valve is replaced by a similar valve taken from a cadaver.
However, the manufacture of the replacement valve requires the tissue to be cut and shaped into the form of the cusps of the valve by the surgeon performing the operation. This is a time-consuming process and demands a high standard of competence on the part of the surgeon.
It is an object of the invention to provide a surgical apparatus by means of which the manufacture of autogenous tissue heart valves is facilitated.
It is a further object of the invention to provide apparatus which includes formers which mould tissue to the shape required.
It is also among the objects of the invention to provide for relative movement of the formers towards and away from each other during manufacture of a valve.
Further objects of the invention will be evident when reading the following description in conjunction with the accompanying diagrammatic drawings, which illustrate by way of example embodiments of the invention, in which:
FIG. 1 is a representation of one embodiment of the invention mounted in a frame;
FIG. 2 shows a perspective view of the co-operating surfaces of formers according to one embodiment;
FIG. 3 shows in perspective a second embodiment of one former; and
FIG. 4 shows a support for use with the embodiments shown in FIGS. 2 and 3.
Referring to the drawings, a male former 11 and a female former 12 (FIG. 2) have complementary surfaces 13 and 14 respectively, which are so shaped as to conform to the configurations of the three cusps of an aortic valve.
The formers 11 and 12 are cylindrical and have respective recesses 15 and 16 in their bases into which fit locating pegs l7 and 18 that form part of a frame 19. The peg 17 is in the form of a spring-loaded plunger to facilitate the insertion of the formers 11 and 12 into the frame 19. The peg 17 is also arranged to be adjustable, so that the spring pressure can be varied and thus provides varying pressure on the tissue. The frame 19 is mounted upon a stand 20 by means of a universal joint 21.
The shapes of the co-operating surfaces 13 and 14 are determined by taking a cast of an aortic valve and transferring the configuration of the cast to the female former 12. The former 12 is then used to cast a male reproduction 22 in a silicone rubber, which is mounted on a poly methyl methacrylate cylinder 23 to form the male former 11. The male former 11 is made in this fashion so that the silicone rubber would act as a cushion and reduce the possibility of damage to tissue placed between the male and female formers.
A support 24 is used to maintain the tissue in the shape formed by the formers 11 and 12 when the tissue is placed therebetween. The support 24, which conforms accurately to the shape of the cusps of the aortic valve, is made of the plastics material known as polypropylene and is covered by biologically compatible woven or knitted plastics material such as Dacron or Teflon.
Referring now to the second embodiment shown in FIG. 3, the male former 11 includes a base 37 from which depend three finger-like members, 38, 39 and 40. The free ends of the members each include a pad 31, 32 and 33 respectively. The pads may be made from silicone rubber.
The member 38 is integral with the base 37. The members 39 and 40 are removable from the base 37, a spring clip 34 and 35 pivoted to the base 37 securing the respective member in seatings (not shown) in the base. The base 37 also includes a recess 15.
As described above with reference to FIG. 2, the former 12 is used to cast and mould to the required shape the pads 31, 32 and 33. The members 38, 39 and 40 and base 37 of the former 11 may suitably be of stainless steel.
In use of the embodiment shown in FIG. 2 to make an autogenous heart valve, the support 24 which is to form part of a valve to be made, is placed in position on the female former 12 with projections 24' coincident with the ridges 14'. Suitable pieces of tissue (not shown) taken for example from the thigh of a patient being operated upon, is then placed between the formers 11 and 12. There are three pieces of tissue, one being placed between each pair of co-operating surfaces 13 and 14. The formers 11 and 12 are then held together and mounted in the frame 19 by means of the pegs 17 and 18. The exposed edges of the tissue are then attached to the support 24 using standard surgical sutures or careful glueing or stapling and trimmed with scissors. The tissue is attached along the curves of the support, conforming to the shape of the valve. This operation is facilitated by the universal joint 21. The formers 11 and 12 are then removed from the frame 19 and separated and the tissue is cut along the lines where the valve cusps meet, again with the aid of scissors.
In use of the embodiment shown in FIG. 3 the support 24 is placed in position on the former 12 with fingers 24' coincident with ridges 14 as previously described. The curved surfaces in the support 24 then correspond with the curved edges on the former 12.
The former is then mounted on the frame 19, the peg 18 on I the frame entering the recess 16. The former 11' with members 39 and 40 removed, is then mounted on the frame, the peg 17 which is spring mounted, entering the recess 15. A single piece of autogenous tissue having one straight edge is then wrapped around the former 12 and then held in position between the pad 31 on the fixed member 38 and one cusp 14 of the former 12. The tissue is then folded into a second cusp and the demountable member 39 is secured in position in the base 37, the spring clip 34 being pivoted downwardly to engage the member 39 and hold it securely in position. The tissue is then securely held between the second cusp 4 and the pad 32 as well as between the first cusp and the pad 31. The same procedure is used with respect to the other member 40. The tissue is thus moulded into the form of a tri-cuspic aortic valve. The edges of the tissue are then attached as before to the support 17 using standard surgical sutures or careful stapling or glueing and trimmed with scissors.
This operation is facilitated by a universal joint 21 on the stand 18.
When the mould is dismantled and the support is removed, a tri-cuspic heart valve is obtained using autogenous fresh tissue, and can be placed in a defective heart.
Thus both embodiments of the invention provide a process which can be carried out quickly and simply by unskilled personnel. Furthermore, the aortic valve produced in the process and apparatus of the invention can be manufactured in the operating theatre while the surgeon is engaged in the early stages of an operation. This enables the surgeon and his assistant to concentrate on the operation and removes the onus of manufacturing the replacement from them, shortens the operation and reduces the risk of infection.
We claim:
1. An apparatus for manufacturing a replacement heart valve comprising tissue taken from a patient, and further comprising forming means including first and second forming members having first and second complementary surfaces, respectively, the first surface being defined by a plurality of projections which conform to the configuration of the cusps of a heart valve, and the second surface being defined by a plurality of recesses which also conform to the configuration of the cusps of a heart valve.
2. An apparatus according to claim 1, including mounting means mounting said first and second forming members for relative linear movement toward and away from each other.
3. An apparatus according to claim 2, wherein the mounting means includes spring means for resiliently urging the first and second forming members in a direction toward each other.
4. An apparatus according to claim 1, including stationary support means, frame means rotatably mounted on said support means, means coacting with said frame means and said support means for selectively fixedly securing said frame means in a selected position relative to said support means, and means mounting said first and second forming members on said frame means for permitting relative linear movement of said forming members toward and away from each other.
5. An apparatus according to claim 4, wherein said frame means includes a substantially U-shaped member rotatably mounted on said support means for rotation about a substantially horizontal axis, and said first and second forming members being mounted on said U-shaped member substantially adjacent the free ends of the legs thereof for relative linear movement in a direction substantially transverse to said horizontal axis.
6. An apparatus according to claim 5, further including spring means coacting between said U-shaped member and one of said forming members for resiliently urging said one forming member into engagement with said other forming member.
7. An apparatus according to claim 1, wherein said first and second forming members are cylindrical, and wherein the projections formed on said first forming member are constructed of an elastomeric material so as to act as a cushion when the forming members are positioned in engagement with one another so as to not damage the tissue placed therebetween.
8. An apparatus according to claim 7, further including a sleeve-like support member positioned in surrounding relationship to said forming members, said support member having projections adjacent one end thereof having a configuration conforming to the shape of the cusps of the heart valve and being made of a plastics material for permitting the edges of the tissue, when positioned between the forming members, to be sewn thereto.
9. An apparatus according to claim 1, wherein the plurality of projections comprise three finger-like members spaced equidistantly around the periphery of one of said forming members for co-operating with said other forming member.
10. An apparatus according to claim 9, wherein two of said finger-like members include means whereby the two fingerlike members are demountable from said one forming member.
11. An apparatus according to claim 9, wherein the fingerlike members each include a pad at one extremity, which pads conform to the configuration of said recesses.
12. An apparatus according to claim 1, wherein the plurality of projections comprise three finger-like members spaced equidistantly around the periphery of one of said forming members, two of said two demountable dismantled from said one forming member.
13. An apparatus according to claim 12, wherein said one forming member includes securing means mounted on said forming member coactig with said two demountable members for securing said finger-like members in said one forming member when inserted in said one forming member.
14. An apparatus according to claim 13, wherein said securing means comprise spring means rotatably mounted on said one former member for coacting with respective stem means of said two finger-like members.
Claims (14)
1. An apparatus for manufacturing a replacement heart valve comprising tissue taken from a patient, and further comprising forming means including first and second forming members having first and second complementary surfaces, respectively, the first surface being defined by a plurality of projections which conform to the configuration of the cusps of a heart valve, and the second surface being defined by a plurality of recesses which also conform to the configuration of the cusps of a heart valve.
2. An apparatus according to claim 1, including mounting means mounting said first and second forming members for relative linear movement toward and away from each other.
3. An apparatus according to claim 2, wherein the mounting means includes spring means for resiliently urging the first and second forming members in a direction toward each other.
4. An apparatus according to claim 1, including stationary support means, frame means rotatably mounted on said support means, means coacting with said frame means and said support means for selectively fixedly securing said frame means in a selected position relative to said support means, and means mounting said first and second forming members on said frame means for permitting relative linear movement of said forming members toward and away from each other.
5. An apparatus according to claim 4, wherein said frame means includes a substantially U-shaped member rotatably mounted on said support means for rotation about a substantially horizontal axis, and said first and second forming members being mounted on said U-shaped member substantially adjacent the free ends of the legs thereof for relative linear movement in a direction substantially transverse to said horizontal axis.
6. An apparatus according to claim 5, further including spring means coacting between said U-shaped member and one of said forming members for resiliently urging said one forming member into engagement with said other forming member.
7. An apparatus according to claim 1, wherein said first and second forming members are cylindrical, and wherein the projections formed on said first forming member are constructed of an elastomeric material so as to act as a cushion when the forming members are positioned in engagement with one another so as to not damage the tissue placed therebetween.
8. An apparatus according to claim 7, further including a sleeve-like support member positioned in surrounding relationship to said forming members, said support member having projections adjacent one end thereof having a configuration conforming to the shape of the cusps of the heart valve and being made of a plastics material for permitting the edges of the tissue, when positioned between the forming members, to be sewn thereto.
9. An apparatus according to claim 1, wherein the plurality of projections comprise three finger-like members spaced equidistantly around the periphery of one of said forming members for co-operating with said other forming member.
10. An apparatus according to claim 9, wherein two of said finger-like members include means whereby the two finger-like members are demountable from said one forming member.
11. An apparatus according to claim 9, wherein the finger-like members each include a pad at one extremity, which pads conform to the configuration of said recesses.
12. An apparatus according to claim 1, wherein the plurality of projections comprise three finGer-like members spaced equidistantly around the periphery of one of said forming members, two of said two demountable dismantled from said one forming member.
13. An apparatus according to claim 12, wherein said one forming member includes securing means mounted on said forming member coactig with said two demountable members for securing said finger-like members in said one forming member when inserted in said one forming member.
14. An apparatus according to claim 13, wherein said securing means comprise spring means rotatably mounted on said one former member for coacting with respective stem means of said two finger-like members.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US374970A | 1970-01-19 | 1970-01-19 |
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US3655306A true US3655306A (en) | 1972-04-11 |
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US3749A Expired - Lifetime US3655306A (en) | 1970-01-19 | 1970-01-19 | Apparatus for molding heart valves |
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Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4139337A (en) * | 1976-12-23 | 1979-02-13 | Loic David | Apparatus for the manufacture of orthopedic insoles |
US4340977A (en) * | 1980-09-19 | 1982-07-27 | Brownlee Richard T | Catenary mitral valve replacement |
US4364127A (en) * | 1981-10-02 | 1982-12-21 | Research Corporation | Trileaflet type prosthetic heart valve |
US4443895A (en) * | 1981-06-22 | 1984-04-24 | American Hospital Supply Corporation | Low-pressure fixation of valvular tissue intended for implantation |
WO1984002304A1 (en) * | 1982-12-15 | 1984-06-21 | Peterson Lab | Method and apparatus for making corrected custom foot molds |
US4477930A (en) * | 1982-09-28 | 1984-10-23 | Mitral Medical International, Inc. | Natural tissue heat valve and method of making same |
US4747989A (en) * | 1982-12-15 | 1988-05-31 | Peterson Laboratories | Method and apparatus for making corrected custom foot molds |
DE4002171A1 (en) * | 1989-10-03 | 1991-04-11 | Martinez Wilson Ramos | BRACKET TO HOLD A HEART VALVE PROSTHESIS DURING THE IMPLANTATION |
US5282328A (en) * | 1989-12-13 | 1994-02-01 | Peterson Technology Trust | Custom foot beds for footwear |
US5509930A (en) * | 1993-12-17 | 1996-04-23 | Autogenics | Stentless heart valve |
WO1997012565A1 (en) * | 1995-10-06 | 1997-04-10 | Cardiomend, L.L.C. | Products and methods for circulatory system valve repair |
US6190391B1 (en) * | 1999-10-01 | 2001-02-20 | Bristol-Myers Squibb Company | Method of preparing a resected posterior surface of a patella to receive a prosthetic element |
US20020029055A1 (en) * | 1990-06-28 | 2002-03-07 | Bonutti Peter M. | Apparatus and method for tissue removal |
US6425902B1 (en) | 2001-05-04 | 2002-07-30 | Cardiomend Llc | Surgical instrument for heart valve reconstruction |
US6491511B1 (en) * | 1999-10-14 | 2002-12-10 | The International Heart Institute Of Montana Foundation | Mold to form stent-less replacement heart valves from biological membranes |
US6598307B2 (en) | 1999-11-17 | 2003-07-29 | Jack W. Love | Device and method for assessing the geometry of a heart valve |
US20040172033A1 (en) * | 1991-08-12 | 2004-09-02 | Bonutti Peter M. | Tissue stabilization device and method |
US20060095125A1 (en) * | 2004-11-02 | 2006-05-04 | Chinn Joseph A | Attachment of a sewing cuff to a heart valve |
EP1864687A1 (en) * | 2006-06-09 | 2007-12-12 | Eidgenössische Technische Hochschule Zürich | Scaffolds for artificial heart valves and vascular structures |
US20090248172A1 (en) * | 2006-06-02 | 2009-10-01 | Eidgenossische Technische Hochschule Zurich | Porous membrane comprising a biocompatible block-copolymer |
US20120191179A1 (en) * | 2010-09-09 | 2012-07-26 | Yasuhide Nakayama | Base material for forming valved lumen shape tissue, method for producing valved lumen shape tissue, and valved artificial blood vessel |
US11179237B2 (en) | 2015-07-22 | 2021-11-23 | Corcym S.R.L. | Valvular sleeve for valvular prostheses and corresponding device |
US11464632B2 (en) | 2014-05-07 | 2022-10-11 | Baylor College Of Medicine | Transcatheter and serially-expandable artificial heart valve |
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US4139337A (en) * | 1976-12-23 | 1979-02-13 | Loic David | Apparatus for the manufacture of orthopedic insoles |
US4340977A (en) * | 1980-09-19 | 1982-07-27 | Brownlee Richard T | Catenary mitral valve replacement |
US4443895A (en) * | 1981-06-22 | 1984-04-24 | American Hospital Supply Corporation | Low-pressure fixation of valvular tissue intended for implantation |
US4364127A (en) * | 1981-10-02 | 1982-12-21 | Research Corporation | Trileaflet type prosthetic heart valve |
US4477930A (en) * | 1982-09-28 | 1984-10-23 | Mitral Medical International, Inc. | Natural tissue heat valve and method of making same |
WO1984002304A1 (en) * | 1982-12-15 | 1984-06-21 | Peterson Lab | Method and apparatus for making corrected custom foot molds |
US4522777A (en) * | 1982-12-15 | 1985-06-11 | Peterson Laboratories | Method and apparatus for making corrected custom foot molds |
US4747989A (en) * | 1982-12-15 | 1988-05-31 | Peterson Laboratories | Method and apparatus for making corrected custom foot molds |
DE4002171A1 (en) * | 1989-10-03 | 1991-04-11 | Martinez Wilson Ramos | BRACKET TO HOLD A HEART VALVE PROSTHESIS DURING THE IMPLANTATION |
US5282328A (en) * | 1989-12-13 | 1994-02-01 | Peterson Technology Trust | Custom foot beds for footwear |
US20020029055A1 (en) * | 1990-06-28 | 2002-03-07 | Bonutti Peter M. | Apparatus and method for tissue removal |
US7896880B2 (en) | 1990-06-28 | 2011-03-01 | P Tech, Llc | Apparatus and method for tissue removal |
US20020055755A1 (en) * | 1990-06-28 | 2002-05-09 | Bonutti Peter M. | Apparatus and method for tissue removal |
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US7134437B2 (en) | 1990-06-28 | 2006-11-14 | Bonutti Ip, Llc | Method for utilizing human tissue |
US20030009147A1 (en) * | 1990-06-28 | 2003-01-09 | Bonutti Peter M. | Biodegradable sac and method of using same |
US7727283B2 (en) | 1991-08-12 | 2010-06-01 | P Tech, Llc. | Tissue stabilizing implant method |
US7462200B2 (en) | 1991-08-12 | 2008-12-09 | Marctec, Llc | Method for tissue grafting |
US20040172033A1 (en) * | 1991-08-12 | 2004-09-02 | Bonutti Peter M. | Tissue stabilization device and method |
US7070557B2 (en) * | 1991-08-12 | 2006-07-04 | Marctec, Llc | Tissue graft material and method of making |
US20060106464A1 (en) * | 1991-08-12 | 2006-05-18 | Bonutti Peter M | Method for tissue grafting |
US20040169311A1 (en) * | 1991-08-12 | 2004-09-02 | Bonutti Peter M. | Tissue graft material and method of making |
US5509930A (en) * | 1993-12-17 | 1996-04-23 | Autogenics | Stentless heart valve |
WO1997012565A1 (en) * | 1995-10-06 | 1997-04-10 | Cardiomend, L.L.C. | Products and methods for circulatory system valve repair |
US5716399A (en) * | 1995-10-06 | 1998-02-10 | Cardiomend Llc | Methods of heart valve repair |
US6129758A (en) * | 1995-10-06 | 2000-10-10 | Cardiomend Llc | Products and methods for circulatory system valve repair |
US6506193B1 (en) * | 1999-10-01 | 2003-01-14 | Zimmer, Inc. | Bone resurfacing apparatus and related procedures |
US6190391B1 (en) * | 1999-10-01 | 2001-02-20 | Bristol-Myers Squibb Company | Method of preparing a resected posterior surface of a patella to receive a prosthetic element |
US6491511B1 (en) * | 1999-10-14 | 2002-12-10 | The International Heart Institute Of Montana Foundation | Mold to form stent-less replacement heart valves from biological membranes |
US6598307B2 (en) | 1999-11-17 | 2003-07-29 | Jack W. Love | Device and method for assessing the geometry of a heart valve |
WO2002089710A1 (en) * | 2001-05-04 | 2002-11-14 | Cardiomend, Llc | Surgical instrument for heart valve reconstruction |
US6425902B1 (en) | 2001-05-04 | 2002-07-30 | Cardiomend Llc | Surgical instrument for heart valve reconstruction |
US20060095125A1 (en) * | 2004-11-02 | 2006-05-04 | Chinn Joseph A | Attachment of a sewing cuff to a heart valve |
US7641687B2 (en) | 2004-11-02 | 2010-01-05 | Carbomedics Inc. | Attachment of a sewing cuff to a heart valve |
US20090248172A1 (en) * | 2006-06-02 | 2009-10-01 | Eidgenossische Technische Hochschule Zurich | Porous membrane comprising a biocompatible block-copolymer |
WO2007140964A3 (en) * | 2006-06-09 | 2008-10-09 | Eidgenoess Tech Hochschule | Scaffolds for artificial heart valves and vascular structures |
WO2007140964A2 (en) * | 2006-06-09 | 2007-12-13 | Eidgenössische Technische Hochschule Zürich | Scaffolds for artificial heart valves and vascular structures |
US20100168832A1 (en) * | 2006-06-09 | 2010-07-01 | Peter Neuenschwander | Scaffolds for artificial heart valves and vascular structures |
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US8562671B2 (en) | 2006-06-09 | 2013-10-22 | Eidgenossische Technische Hochschule Zurich | Scaffolds for artificial heart valves and vascular structures |
US20120191179A1 (en) * | 2010-09-09 | 2012-07-26 | Yasuhide Nakayama | Base material for forming valved lumen shape tissue, method for producing valved lumen shape tissue, and valved artificial blood vessel |
US8685082B2 (en) * | 2010-11-18 | 2014-04-01 | National Cerebral And Cardiovascular Center | Base material for forming valved lumen shape tissue, method for producing valved lumen shape tissue, and valved artificial blood vessel |
US11464632B2 (en) | 2014-05-07 | 2022-10-11 | Baylor College Of Medicine | Transcatheter and serially-expandable artificial heart valve |
US11571300B2 (en) | 2014-05-07 | 2023-02-07 | Baylor College Of Medicine | Serially expanding an artificial heart valve within a pediatric patient |
US11179237B2 (en) | 2015-07-22 | 2021-11-23 | Corcym S.R.L. | Valvular sleeve for valvular prostheses and corresponding device |
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