US3586064A - Blood serum collection tube and method of collection - Google Patents

Blood serum collection tube and method of collection Download PDF

Info

Publication number
US3586064A
US3586064A US3586064DA US3586064A US 3586064 A US3586064 A US 3586064A US 3586064D A US3586064D A US 3586064DA US 3586064 A US3586064 A US 3586064A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
apparatus
needle
tube
serum
collection tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Paul A Brown
Joseph O'brien
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Metropolitan Pathology Lab Inc
Original Assignee
Metropolitan Pathology Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5021Test tubes specially adapted for centrifugation purposes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/491Blood by separating the blood components
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/041Connecting closures to device or container
    • B01L2300/044Connecting closures to device or container pierceable, e.g. films, membranes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/04Closures and closing means
    • B01L2300/046Function or devices integrated in the closure
    • B01L2300/048Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0672Integrated piercing tool
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0475Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0478Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/06Valves, specific forms thereof
    • B01L2400/0633Valves, specific forms thereof with moving parts
    • B01L2400/0638Valves, specific forms thereof with moving parts membrane valves, flap valves

Abstract

The disclosure relates to an apparatus and a method for removing serum from the uppermost portions of a specimen tube of centrifuged blood, in which the blood serum is disposed in a liquid pool above settled-out cellular solid materials. More particularly, the invention is directed to an easily handleable, readily mailable, collection tube closed at both ends by ''''oneshot'''' valve structures comprising self-sealing elastomeric elements pierced by hollow needles. Additionally, at least the lower valve element is definitive of a pistonlike member which is adapted to engage the inner walls of the specimen tube to pump serum therefrom.

Description

United States Patent Paul A. Brown Portsmouth, NJL;

Joseph OBrien, Teaneck, NJ.

Sept. 3, 1969 June 22, 1971 Metropolitan Pathology Laboratory, lnc. Teaneck, NJ.

Inventors Appl. No. Filed Patented Assignee BLOOD SERUM COLLECTION TUBE AND Primary Examiner-Laverne D. Geiger Assistant Examiner-Edward J. Earls Attorney-Mandeville and Schweitzer ABSTRACT: The disclosure relates to an apparatus and a method for removing serum from the uppermost portions of a specimen tube of centrifuged blood, in which the blood serum is disposed in a liquid pool above settled-out cellular solid materials. More particularly, the invention is directed to an easily handleable, readily mailable, collection tube closed at both ends by one-shot" valve structures comprising self-sealing elastomeric elements pierced by hollow needles. Additionally, at least the lower valve element is definitive of a pistonlike member which is adapted to engage the inner walls of the specimen tube to pump serum therefrom.

PATENTED JUN22 197:

(FIG. 4

INVENTORS PAU L BROW N BY JOSEPH O'BRIEN ffl ATTOR EYS BLOOD SERUM COLLECTION TUBE AND METHOD OF COLLECTION BACKGROUND OF THE INVENTION ln the examination of blood samples in pathological laboratories, it is often necessary or desirable to examine blood serum after it has been separated from the suspended cellular material, and for this purpose it is customary to subject the specimen tubes, in which the blood samples are delivered to the laboratory, to centrifuging action to cause the settling of the cells to the bottom of the specimen tube. Since many laboratories process large numbers of blood samples every day, facility of handling specimens, accuracy of labeling of specimens, and the ease of drawing ofi and retaining serum specimens are important to successful and safe operation.

Quite often, laboratory workers have experienced difficulty in efficiently removing the clear serum from centrifuged blood specimen tube, without disturbing the settled out solid material. Additionally there have been problems in maintaining with accuracy the identity of the source (patient) from which the serum was originally obtained throughout its travels from hospital to laboratory, etc.

l-leretofore, the blood serum has been removed from the specimen tube, after the blood has been centrifuged to separate the serum from the clotted cells by drawing the serum off with a conventional syringe; by pouring the serum off through tilting of the specimen tube; by use of pipettes and the like; and or by use of plungerlike apparatus of the type disclosed in U.S. Pat. No. 3,355,098.

SUMMARY OF THE PRESENT lNVENTlON The shortcomings of the prior art devices have been overcome by the method and apparatus of the present invention, which provide a new and improved method of collecting serum and a new and improved self-sealing, serum collection tube, and which tube may be directly filled from centrifuged specimen tubes with collected blood serum. The new serum collection tube basically comprises a hollow cylinder whose ends are closed off by novel one-shot" valves, one of which also functions as a piston member. The valves comprise selfsealing elastomeric end caps pierced by removable hollow needles.

For a more complete understanding of the present invention and its attendant advantages, reference should be made to the following detailed description taken in conjunction with the accompanying drawings.

DESCRIPTION OF THE DRAWINGS FIG. 1 is a cross-sectional view of the apparatus of the present invention with its upper and lower, one-shot" valves opened in preparation for collecting a serum sample from a specimen tube;

FlG. 2 is a cross-sectional view of the apparatus of FIG. 1 during serum collection with both valves opened;

E10. 3 is a crosssectional view of the apparatus of the invention with the upper end of the collection tube closed off by removal of the upper needle to capture and to retain the serum sample in the collection tube prior to withdrawal of the same from the specimen tube; and

FIG. 43 is a front elevational view of the collection tube with both ends self-sealed and with the blood serum safely trapped therein in accordance with the principles of the present invention.

DETAILED DESCRIPTION OF THE INVENTION Referring now to FIG. 1, there is shown a conventional centrifuged specimen collection tube having a pool of serum 11 disposed above settled-out, clotted cellular material 12. The specimen tube advantageously may be of the so-called vacutainer" type sold by Becton-Dickinson Co. for use by medical personnel in withdrawing blood samples from patients for subsequent laboratory analysis. Such specimen tubes typically have inside diameters of approximately flve-eighths inch. Their lengths generally will vary depending upon the size of the volumetric samples of blood required. Once drawn, blood samples are centrifuged in accordance with well-known known procedures to separate within the specimen tube 10 the serum 11 and cellular matter 12, as shown in FIG. 1.

The new and improved serum collection apparatus 9 of the present invention, includes an elongated cylindrical collection tube 15 which is open at its upper and lower ends. Integral annular beads or flanges l6, 17 are formed at the upper and lower ends respectively of the collection tube 15, as shown.

In accordance with the principles of the invention, the upper end of the collection tube 15 is closed off by a generally cup-shaped, elastomeric, self-sealing element 18 which is mechanically connected .to the collection tube by means of a resilient, split snap ring 19 which engages the outer surface of the element 18, as shown in H0. 1., to hold the element 18 to the flange 16. Any other'suitable mechanical means, such as threads, keys, locks, etc. may be employed in lieu of the snap ring arrangement, as should be understood. The upper sealing element 18 is pierced by a narrow, hollow needle 20, such as a hardened steel syringe needle, which provides communication between the inside of the tube 15 and the atmosphere. Advantageously, the needle 20 mounts a head or grippable portion 21 which is adapted to be grasped by a user to facilitate the subsequent removal of the needle 20 from the sealing element 18 after serum collection. In accordance with the principles of the invention, the sealing element 18 and the needle 20 comprise an upper, selectively actuatable one-shot" valve.

The upper end of the collection tube, in a manner similar to the lower end, is closed off by a generally cup-shaped, elastomeric, self-sealing element. A resilient split, snap ring 23 or other suitable means mechanically fastens the element 22 to the flanged, lower end of the tube, as shown. In accordance with the principles of the invention, a lower elongated, hollow needle 24, similar in construction to the aforementioned needle 20, extends through the sealing element 22 to provide communication through the lower end of the collection tube. The lower needle 24 mounts a grippable portion 25 which may be readily grasped to remove the needle 24 from the sealing element 22;

As an important aspect of the present invention, the lower cup-shaped element 22 together with the needle 24 also defines a one-shot" valve, the outer diameter of which is slightly greater than the inner diameter of the tube 10. Thus the sealing element 22 is able to function as a piston element when inserted in telescoping association with the specimen tube. That is to say, the cylindrical outer surfaces of the sealing element 22 are appropriately dimensioned (c.g. slightly greater than flve-eighths inch in diameter) so that the element 22 sealingly, slidingly engages the inner walls of the specimen tube when inserted therein, as shown in FIGS. 2 and 3.

In accordance with the invention, blood serum may be removed from the centrifuged specimen tube 10 and securely trapped within the collection tube 15 in the following manner. The lower end of the collection tube 15 is inserted into the specimen tube, as shown in FIG. 2, and plunged downwardly therein, while the upper one-shot" valve is open to the atmosphere. In accordance with well-known principles of pumps, the serum will be driven by the pumplike" action of the piston 22 and up through the open needle 24 and into the collection tube 15, without disturbing the clotted matter 12. When sufficient serum has been collected in this manner to cover the needle opening 24', the upper needle 20 is removed from the self-sealing, elastomeric cap 18 by merely gripping the portion 21 and pulling outwardly thereon and then it is discarded. This closes the upper one-shot" valve and will seal off the upper end of the collection tube 15 to capture the serum collected therein, in accordance with well-known principles of physics, and in spite of the fact that the lower needle 25 is still present in the collection tube.

Thereafter, the collection tube apparatus 9 is withdrawn from the specimen tube W, as shown in FIG. 3, and the collected serum M is permanently trapped in the collection tube 15 by removing the lower needle 2% by grasping and pulling outwardly on the lower gripping portion 25. This closes the lower one-shot valve to provide a completely sealed collection tube 115. The lower needle 24 then may be discarded and the filled tube 15 may be readily mailed to pathology laboratories for testing analysis, etc. in a suitable mailing envelope M (shown in phantom in FIG. 1).

In accordance with a more specific aspect of the invention, the sealing elements R8, 22 are advantageously made of rubber and the collection tube 15 is made from glass. The tube 15 has an etched labeling portion 26 integral therewith upon which suitable identifying indicia may be inscribed to ensure accurate handling.

It should be understood that the blood serum collection method and apparatus herein illustrated and described are intended to be representative only, as certain changes may be made therein without departing from the clear teachings of the disclosure. Accordingly, reference should be made to the following appended claims in determining the full scope of the invention.

We claim:

1. Apparatus for removing and trapping the upper portions of a pool of liquid contained in a specimen tube having a predetermined inner diameter, comprising:

a. a cylindrical tubular element open at its upper and lower ends and having an outer diameter less than said predetermined inner diameter of the specimen tube,

b. selectively actuatable upper valve means closing off said upper end of said tubular element and being adapted to provide communication between interior upper portions of said tubular element and atmosphere,

c. Lower valve means closing off the lower end of said tubular element and being adapted to communicate between said inner portions of said tubular element and the liquid in said pool,

(I. said lower valve means comprising a puncturable, first elastomeric sealing means and a first hollow needle extending therethrough,

e. said elastomeric material possessing sufficient resilience and said first hollow needle being sufficiently narrow whereby on the removal of said first needle from said elastomeric material said lower end of the tubular member will be completely self sealed, said first sealing means defining a cylindrical piston head having an outer diameter slightly greater than said predetermined inner diameter of said specimen tube, whereby said piston head is adapted to make sliding, sealing contact therewith.

The apparatus of claim 1, in which: a. said upper valve means includes a second elastomeric sealing material cover said upper end and a second hollow needle extending therethrough,

b. said second elastomeric material possesses sufficient resilience and said second hollow needle is sufficiently narrow whereby up on the removal of said second needle from said second elastomeric material said upper end of the tubular member will be completely self-sealed.

3. The apparatus of claim 2, in which:

a. the second needle mounts a gripping means by which the second needle may be removed from said second elastomeric material.

4. The apparatus of claim 2, in which:

a. a mechanical means joins said second elastomeric sealing means to said upper end of the tubular member.

5. The apparatus of claim 41, in which:

a. said mechanical means includes a resilient snap ring, and

b. said elastomeric sealing means comprises a generally cupshaped member,

c. the uppermost end of said tubular member includes an annular bead.

6. The apparatus of claim 11, in which: a. the first needle mounts a gripping means by WhlCh the first needle may be removed from said first elastomeric material.

7. The apparatus of claim 1, in which:

a. a mechanical means joins said first elastomeric sealing means to said lower end of the tubular member.

8. The apparatus of claim 7, in which:

a. said mechanical means includes a resilient snap ring,

b. said elastomeric sealing means comprises a generally cupshaped member,

c. the uppermost end of said tubular member includes an annular bead.

9. The apparatus of claim l, in which:

a. said tubular member is transparent.

10. The apparatus of claim 1, in which:

a. said tubular member is glass, and

b. predetermined portions of said glass are etched and thereby adapted to be indicia bearing.

ll. A method of removing serum from a specimen tube 40 comprising the steps of:

inserting a tubular plungerclosed off at its lower end by a pistonlike element pierced by a hollow needle into the specimen tube to drive serum upwardly therethrough and into said collection tube,

b. maintaining the upper end of said collection tube open to atmosphere while said collection is driven downwardly into said serum,

c. closing off the upper end of said collection tube from atmosphere upon termination of the downward stroke of said collection tube,

d. removing said collection tube from said specimen tube,

and

e. closing off the lower end of said collection tube by removing said needle from the lower end thereof.

Claims (10)

  1. 2. The apparaTus of claim 1, in which: a. said upper valve means includes a second elastomeric sealing material cover said upper end and a second hollow needle extending therethrough, b. said second elastomeric material possesses sufficient resilience and said second hollow needle is sufficiently narrow whereby up on the removal of said second needle from said second elastomeric material said upper end of the tubular member will be completely self-sealed.
  2. 3. The apparatus of claim 2, in which: a. the second needle mounts a gripping means by which the second needle may be removed from said second elastomeric material.
  3. 4. The apparatus of claim 2, in which: a. a mechanical means joins said second elastomeric sealing means to said upper end of the tubular member.
  4. 5. The apparatus of claim 4, in which: a. said mechanical means includes a resilient snap ring, and b. said elastomeric sealing means comprises a generally cup-shaped member, c. the uppermost end of said tubular member includes an annular bead.
  5. 6. The apparatus of claim 1, in which: a. the first needle mounts a gripping means by which the first needle may be removed from said first elastomeric material.
  6. 7. The apparatus of claim 1, in which: a. a mechanical means joins said first elastomeric sealing means to said lower end of the tubular member.
  7. 8. The apparatus of claim 7, in which: a. said mechanical means includes a resilient snap ring, b. said elastomeric sealing means comprises a generally cup-shaped member, c. the uppermost end of said tubular member includes an annular bead.
  8. 9. The apparatus of claim 1, in which: a. said tubular member is transparent.
  9. 10. The apparatus of claim 1, in which: a. said tubular member is glass, and b. predetermined portions of said glass are etched and thereby adapted to be indicia bearing.
  10. 11. A method of removing serum from a specimen tube comprising the steps of: inserting a tubular plunger closed off at its lower end by a pistonlike element pierced by a hollow needle into the specimen tube to drive serum upwardly therethrough and into said collection tube, b. maintaining the upper end of said collection tube open to atmosphere while said collection is driven downwardly into said serum, c. closing off the upper end of said collection tube from atmosphere upon termination of the downward stroke of said collection tube, d. removing said collection tube from said specimen tube, and e. closing off the lower end of said collection tube by removing said needle from the lower end thereof.
US3586064A 1969-09-03 1969-09-03 Blood serum collection tube and method of collection Expired - Lifetime US3586064A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US85498269 true 1969-09-03 1969-09-03

Publications (1)

Publication Number Publication Date
US3586064A true US3586064A (en) 1971-06-22

Family

ID=25320049

Family Applications (1)

Application Number Title Priority Date Filing Date
US3586064A Expired - Lifetime US3586064A (en) 1969-09-03 1969-09-03 Blood serum collection tube and method of collection

Country Status (1)

Country Link
US (1) US3586064A (en)

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3719410A (en) * 1971-11-10 1973-03-06 Farrand Optical Co Inc Mixing and measuring apparatus
US3771965A (en) * 1971-04-23 1973-11-13 R Grams Biological fluid sampling apparatus
US3782548A (en) * 1972-12-07 1974-01-01 J Bowen Serum skimmer
US3799342A (en) * 1970-07-27 1974-03-26 Medical Res & Dev Inc Method of using a serum separator
US3814079A (en) * 1972-04-28 1974-06-04 Upjohn Co Liquid collecting and filtering device
US3814248A (en) * 1971-09-07 1974-06-04 Corning Glass Works Method and apparatus for fluid collection and/or partitioning
US3814258A (en) * 1973-03-15 1974-06-04 Dickinson And Co Blood plasma separator with filter
US3853011A (en) * 1972-06-14 1974-12-10 H Baumann Method and apparatus for the suction removal of a liquid
US3873449A (en) * 1973-04-05 1975-03-25 Baxter Laboratories Inc Filter skimming apparatus
US3882021A (en) * 1974-02-27 1975-05-06 Becton Dickinson Co Sealed assembly for separation of blood with anti-red cell barrier
US3891553A (en) * 1974-02-27 1975-06-24 Becton Dickinson Co Serum and plasma separator {13 {0 constrictionless type
US3905528A (en) * 1974-04-10 1975-09-16 Hugh V Maiocco Two-piece concentric centrifuge sample container
US3920557A (en) * 1974-02-27 1975-11-18 Becton Dickinson Co Serum/plasma separator--beads-plus-adhesive type
US3932277A (en) * 1974-03-29 1976-01-13 Bio-Logics Products, Inc. Method and apparatus for separating blood fractions
FR2276590A1 (en) * 1974-06-24 1976-01-23 Mediplast Ab Device to transfer blood or similar fluid into a pipette
US3941699A (en) * 1974-02-27 1976-03-02 Becton, Dickinson And Company Plasma separator with centrifugal valve
US3955423A (en) * 1972-09-18 1976-05-11 Marvin Padover Liquid sampling method
US4022576A (en) * 1975-06-09 1977-05-10 I. C. L. Scientific Method and apparatus for preparation of liquids containing suspended material for examination
US4057499A (en) * 1973-03-09 1977-11-08 Buono Frank S Apparatus and method for separation of blood
US4119125A (en) * 1977-06-22 1978-10-10 Elkins Carlos D Method and apparatus for handling liquid samples
US4142668A (en) * 1976-10-01 1979-03-06 Lee Jae Y Serum-plasma separator and transfer apparatus
US4197735A (en) * 1978-11-06 1980-04-15 Chase Instruments Corporation Blood sedimentation rate test means
US4209488A (en) * 1978-10-10 1980-06-24 Owens-Illinois, Inc. Fluid collection apparatus
US4210623A (en) * 1978-05-01 1980-07-01 Owens-Illinois, Inc. Fluid collection apparatus
US4234317A (en) * 1979-05-24 1980-11-18 Analytical Products, Inc. Apparatus and method for fractionation of lipoproteins
FR2471204A1 (en) * 1979-12-12 1981-06-19 Michael Cais Method and mass transfer device with at least one component from a liquid phase to another liquid phase, with separation of these two phases in the same device
DE3001409A1 (en) * 1980-01-16 1981-08-06 Rostislav Dr Caletka Conical connection between syringe cylinder and outlet - for sepn. of immiscible liquids
US4305303A (en) * 1980-02-19 1981-12-15 Texaco Inc. Sampling device and methods for collecting a lighter medium floating on a heavier medium
US4346608A (en) * 1980-07-31 1982-08-31 The United States Of America As Represented By The Secretary Of The Army Float device for density gradient fractionation
US4487696A (en) * 1978-08-14 1984-12-11 Ferrara Louis T Blood separator and dispenser
US4644807A (en) * 1985-02-21 1987-02-24 Dionex Corporation Fluid sample delivery apparatus
DE9013914U1 (en) * 1990-10-05 1991-02-14 Walter Sarstedt Geraete Und Verbrauchsmaterial Fuer Medizin Und Wissenschaft, 5223 Nuembrecht, De
US5257529A (en) * 1990-12-28 1993-11-02 Nissho Corporation Method and device for measurement of viscosity of liquids
US5340546A (en) * 1993-04-05 1994-08-23 David Bromley Gas filter
US5393494A (en) * 1992-05-28 1995-02-28 Diasys Corporation Apparatus for drawing fluid sample, components thereof, and slide assembly for use therewith
US5552064A (en) * 1993-02-26 1996-09-03 Ortho Diagnostic Systems, Inc. Column agglutination assay and device using biphasic centrifugation
US5855852A (en) * 1995-04-01 1999-01-05 Boehringer Mannheim Gmbh Vessel for reducing contamination in the treatment of liquids
US5919356A (en) * 1994-12-24 1999-07-06 Fsm Technologies Ltd. Fluid sampling device
US5968018A (en) * 1996-10-30 1999-10-19 Cohesion Corporation Cell separation device and in-line orifice mixer system
US5997811A (en) * 1997-07-02 1999-12-07 Cohesion Technologies, Inc. Method for sterile syringe packaging and handling
US6132353A (en) * 1996-10-21 2000-10-17 Winkelman; James W. Apparatus and method for separating plasma or serum from the red cells of a blood sample
US20020072703A1 (en) * 2000-07-18 2002-06-13 Peter Nollert Method and apparatus for preparing lipidic mesophase material
US20020160443A1 (en) * 1998-05-09 2002-10-31 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
WO2003028844A1 (en) * 2001-10-04 2003-04-10 Ikonisys, Inc. System and method for fractionation of a centrifuged sample
US20030175167A1 (en) * 2002-03-18 2003-09-18 Arai Takanori Apparatus for separating biological sample and separating method of the same
US20040171937A1 (en) * 2002-09-23 2004-09-02 Scimed Life Systems, Inc. Systems and methods for flushing catheters
US20060196885A1 (en) * 2005-02-21 2006-09-07 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
US20080206774A1 (en) * 1998-05-09 2008-08-28 Ikonisys, Inc. Automated cancer diagnostic methods using fish
US20080241848A1 (en) * 1998-05-09 2008-10-02 Ikonisys, Inc. Methods for prenatal diagnosis of aneuploidy
US20090111101A1 (en) * 1998-05-09 2009-04-30 Ikonisys, Inc. Automated Cancer Diagnostic Methods Using FISH
US20090250413A1 (en) * 2008-04-04 2009-10-08 Biomet Biologics, Llc Sterile Blood Separating System
US20100081166A1 (en) * 2008-09-30 2010-04-01 Tyco Healthcare Group Lp Microbial Detection Assembly
WO2011032530A1 (en) * 2009-09-18 2011-03-24 Hans-Werner Heinrich Disposable device for storing biological liquids and use thereof to detect materials, particles, and/or cells
US8182769B2 (en) 2008-04-04 2012-05-22 Biomet Biologics, Llc Clean transportation system
WO2012118392A1 (en) * 2011-03-01 2012-09-07 Infogene Lda. Portable device for the storage, transport and recuperation of biological material
US20160167061A1 (en) * 2014-12-15 2016-06-16 Akadeum Life Sciences, LLC Method and system for buoyant separation

Cited By (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799342A (en) * 1970-07-27 1974-03-26 Medical Res & Dev Inc Method of using a serum separator
US3771965A (en) * 1971-04-23 1973-11-13 R Grams Biological fluid sampling apparatus
US3814248A (en) * 1971-09-07 1974-06-04 Corning Glass Works Method and apparatus for fluid collection and/or partitioning
US3719410A (en) * 1971-11-10 1973-03-06 Farrand Optical Co Inc Mixing and measuring apparatus
US3814079A (en) * 1972-04-28 1974-06-04 Upjohn Co Liquid collecting and filtering device
US3853011A (en) * 1972-06-14 1974-12-10 H Baumann Method and apparatus for the suction removal of a liquid
US3955423A (en) * 1972-09-18 1976-05-11 Marvin Padover Liquid sampling method
US3782548A (en) * 1972-12-07 1974-01-01 J Bowen Serum skimmer
US4057499A (en) * 1973-03-09 1977-11-08 Buono Frank S Apparatus and method for separation of blood
US3814258A (en) * 1973-03-15 1974-06-04 Dickinson And Co Blood plasma separator with filter
US3873449A (en) * 1973-04-05 1975-03-25 Baxter Laboratories Inc Filter skimming apparatus
US3882021A (en) * 1974-02-27 1975-05-06 Becton Dickinson Co Sealed assembly for separation of blood with anti-red cell barrier
US3920557A (en) * 1974-02-27 1975-11-18 Becton Dickinson Co Serum/plasma separator--beads-plus-adhesive type
US3941699A (en) * 1974-02-27 1976-03-02 Becton, Dickinson And Company Plasma separator with centrifugal valve
US3891553A (en) * 1974-02-27 1975-06-24 Becton Dickinson Co Serum and plasma separator {13 {0 constrictionless type
US3932277A (en) * 1974-03-29 1976-01-13 Bio-Logics Products, Inc. Method and apparatus for separating blood fractions
US3905528A (en) * 1974-04-10 1975-09-16 Hugh V Maiocco Two-piece concentric centrifuge sample container
FR2276590A1 (en) * 1974-06-24 1976-01-23 Mediplast Ab Device to transfer blood or similar fluid into a pipette
US4022576A (en) * 1975-06-09 1977-05-10 I. C. L. Scientific Method and apparatus for preparation of liquids containing suspended material for examination
US4142668A (en) * 1976-10-01 1979-03-06 Lee Jae Y Serum-plasma separator and transfer apparatus
US4119125A (en) * 1977-06-22 1978-10-10 Elkins Carlos D Method and apparatus for handling liquid samples
US4210623A (en) * 1978-05-01 1980-07-01 Owens-Illinois, Inc. Fluid collection apparatus
US4487696A (en) * 1978-08-14 1984-12-11 Ferrara Louis T Blood separator and dispenser
US4209488A (en) * 1978-10-10 1980-06-24 Owens-Illinois, Inc. Fluid collection apparatus
WO1980000923A1 (en) * 1978-11-06 1980-05-15 R Munzer Blood sedimentation rate test means
US4197735A (en) * 1978-11-06 1980-04-15 Chase Instruments Corporation Blood sedimentation rate test means
US4234317A (en) * 1979-05-24 1980-11-18 Analytical Products, Inc. Apparatus and method for fractionation of lipoproteins
FR2471204A1 (en) * 1979-12-12 1981-06-19 Michael Cais Method and mass transfer device with at least one component from a liquid phase to another liquid phase, with separation of these two phases in the same device
DE3001409A1 (en) * 1980-01-16 1981-08-06 Rostislav Dr Caletka Conical connection between syringe cylinder and outlet - for sepn. of immiscible liquids
US4305303A (en) * 1980-02-19 1981-12-15 Texaco Inc. Sampling device and methods for collecting a lighter medium floating on a heavier medium
US4346608A (en) * 1980-07-31 1982-08-31 The United States Of America As Represented By The Secretary Of The Army Float device for density gradient fractionation
US4644807A (en) * 1985-02-21 1987-02-24 Dionex Corporation Fluid sample delivery apparatus
DE9013914U1 (en) * 1990-10-05 1991-02-14 Walter Sarstedt Geraete Und Verbrauchsmaterial Fuer Medizin Und Wissenschaft, 5223 Nuembrecht, De
US5257529A (en) * 1990-12-28 1993-11-02 Nissho Corporation Method and device for measurement of viscosity of liquids
US5393494A (en) * 1992-05-28 1995-02-28 Diasys Corporation Apparatus for drawing fluid sample, components thereof, and slide assembly for use therewith
US5552064A (en) * 1993-02-26 1996-09-03 Ortho Diagnostic Systems, Inc. Column agglutination assay and device using biphasic centrifugation
US5650068A (en) * 1993-02-26 1997-07-22 Ortho Diagnostic Systems Inc. Column agglutination assay and device using biphasic centrifugation
US5340546A (en) * 1993-04-05 1994-08-23 David Bromley Gas filter
US5919356A (en) * 1994-12-24 1999-07-06 Fsm Technologies Ltd. Fluid sampling device
US5855852A (en) * 1995-04-01 1999-01-05 Boehringer Mannheim Gmbh Vessel for reducing contamination in the treatment of liquids
US6132353A (en) * 1996-10-21 2000-10-17 Winkelman; James W. Apparatus and method for separating plasma or serum from the red cells of a blood sample
US6398705B1 (en) * 1996-10-21 2002-06-04 Manfred Grumberg Apparatus for separating plasma or serum from the red cells with a blood sample
US5968018A (en) * 1996-10-30 1999-10-19 Cohesion Corporation Cell separation device and in-line orifice mixer system
US5997811A (en) * 1997-07-02 1999-12-07 Cohesion Technologies, Inc. Method for sterile syringe packaging and handling
US20060078877A1 (en) * 1998-05-09 2006-04-13 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US20020160443A1 (en) * 1998-05-09 2002-10-31 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US7945391B2 (en) 1998-05-09 2011-05-17 Iknonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US7901887B2 (en) 1998-05-09 2011-03-08 Ikonisys, Inc. Automated cancer diagnostic methods using fish
US20080206774A1 (en) * 1998-05-09 2008-08-28 Ikonisys, Inc. Automated cancer diagnostic methods using fish
US20090111101A1 (en) * 1998-05-09 2009-04-30 Ikonisys, Inc. Automated Cancer Diagnostic Methods Using FISH
US7835869B2 (en) 1998-05-09 2010-11-16 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US7640112B2 (en) 1998-05-09 2009-12-29 Ikenisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US20060068377A1 (en) * 1998-05-09 2006-03-30 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US20060068375A1 (en) * 1998-05-09 2006-03-30 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US20060068376A1 (en) * 1998-05-09 2006-03-30 Ikonisys, Inc. Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis
US20080241848A1 (en) * 1998-05-09 2008-10-02 Ikonisys, Inc. Methods for prenatal diagnosis of aneuploidy
US6821487B2 (en) * 2000-07-18 2004-11-23 Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
US20040096364A1 (en) * 2000-07-18 2004-05-20 Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
US7410803B2 (en) 2000-07-18 2008-08-12 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
US20040092034A1 (en) * 2000-07-18 2004-05-13 Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
US7482166B2 (en) 2000-07-18 2009-01-27 The Regents Of The University Of California Method and apparatus for preparing lipidic mesophase material
US20020072703A1 (en) * 2000-07-18 2002-06-13 Peter Nollert Method and apparatus for preparing lipidic mesophase material
WO2003028844A1 (en) * 2001-10-04 2003-04-10 Ikonisys, Inc. System and method for fractionation of a centrifuged sample
US7323144B2 (en) * 2002-03-18 2008-01-29 Leisure, Inc. Apparatus for separating biological sample and separating method of the same
US20030175167A1 (en) * 2002-03-18 2003-09-18 Arai Takanori Apparatus for separating biological sample and separating method of the same
US7819848B2 (en) 2002-09-23 2010-10-26 Boston Scientific Scimed, Inc. Systems and methods for flushing catheters
US20040171937A1 (en) * 2002-09-23 2004-09-02 Scimed Life Systems, Inc. Systems and methods for flushing catheters
US8444620B2 (en) 2005-02-21 2013-05-21 Biomet Biologics, Llc Method and apparatus for application of a fluid
US20100274206A1 (en) * 2005-02-21 2010-10-28 Biomet Manufacturing Corp. Method and Apparatus for Application of a Fluid
US7766900B2 (en) 2005-02-21 2010-08-03 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
US20060196885A1 (en) * 2005-02-21 2006-09-07 Biomet Manufacturing Corp. Method and apparatus for application of a fluid
US9028457B2 (en) 2005-02-21 2015-05-12 Biomet Biologics, Llc Method and apparatus for application of a fluid
US9211487B2 (en) 2008-04-04 2015-12-15 Biomet Biologics, Llc Sterile blood separating system
US8182769B2 (en) 2008-04-04 2012-05-22 Biomet Biologics, Llc Clean transportation system
US8518272B2 (en) 2008-04-04 2013-08-27 Biomet Biologics, Llc Sterile blood separating system
US20090250413A1 (en) * 2008-04-04 2009-10-08 Biomet Biologics, Llc Sterile Blood Separating System
US8633016B2 (en) * 2008-09-30 2014-01-21 Covidien Lp Microbial detection assembly
US20100081166A1 (en) * 2008-09-30 2010-04-01 Tyco Healthcare Group Lp Microbial Detection Assembly
WO2011032530A1 (en) * 2009-09-18 2011-03-24 Hans-Werner Heinrich Disposable device for storing biological liquids and use thereof to detect materials, particles, and/or cells
WO2012118392A1 (en) * 2011-03-01 2012-09-07 Infogene Lda. Portable device for the storage, transport and recuperation of biological material
US9554780B2 (en) 2011-03-01 2017-01-31 Infogene Lda. Portable device for the storage, transport and recuperation of biological material
US20160167061A1 (en) * 2014-12-15 2016-06-16 Akadeum Life Sciences, LLC Method and system for buoyant separation
WO2016100290A1 (en) * 2014-12-15 2016-06-23 Akadeum Life Sciences, LLC Method and system for buoyant separation

Similar Documents

Publication Publication Date Title
US3136440A (en) Self sealing pierceable stopper for sealed containers
US3494352A (en) Apparatus for taking multiple samples
US3525264A (en) Micropipette holder
US3190731A (en) Sample-supply cups for analysis apparatus
US6054099A (en) Urine specimen container
US3835835A (en) Two compartment locking sampling syringe
US6634243B1 (en) Sample testing device
US4416290A (en) Multiple sample needle assembly with vein indication
US4055501A (en) Fluid collection device with phase partitioning means
US5065768A (en) Self-sealing fluid conduit and collection device
US3596652A (en) Fluid separatory device
US5638828A (en) Fluid sample collection and introduction device and method
US3814522A (en) Specimen tube for microscopic examination
US4046699A (en) Access device for centrifugal separation assemblies
US4088582A (en) Blood phase separation means
US4879098A (en) Device for the separation of the lighter fraction from the heavier fraction of a liquid sample
US20050281713A1 (en) System and method for sample collection
US3127892A (en) Blood handling apparatus
US4266559A (en) Blood sampler
US5456885A (en) Fluid collection, separation and dispensing tube
US4962041A (en) Method and apparatus for automatic processing and analyzing of blood serum
US5560830A (en) Separator float and tubular body for blood collection and separation and method of use thereof
US4154229A (en) Blood collection system with venipuncture indicator
US4133304A (en) Syringe-like apparatus with removable capillary cartridge
US4142668A (en) Serum-plasma separator and transfer apparatus