US3586064A - Blood serum collection tube and method of collection - Google Patents
Blood serum collection tube and method of collection Download PDFInfo
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- US3586064A US3586064A US854982A US3586064DA US3586064A US 3586064 A US3586064 A US 3586064A US 854982 A US854982 A US 854982A US 3586064D A US3586064D A US 3586064DA US 3586064 A US3586064 A US 3586064A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
- B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0672—Integrated piercing tool
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0478—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure pistons
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
Definitions
- the disclosure relates to an apparatus and a method for removing serum from the uppermost portions of a specimen tube of centrifuged blood, in which the blood serum is disposed in a liquid pool above settled-out cellular solid materials. More particularly, the invention is directed to an easily handleable, readily mailable, collection tube closed at both ends by one-shot" valve structures comprising self-sealing elastomeric elements pierced by hollow needles. Additionally, at least the lower valve element is definitive of a pistonlike member which is adapted to engage the inner walls of the specimen tube to pump serum therefrom.
- the blood serum has been removed from the specimen tube, after the blood has been centrifuged to separate the serum from the clotted cells by drawing the serum off with a conventional syringe; by pouring the serum off through tilting of the specimen tube; by use of pipettes and the like; and or by use of plungerlike apparatus of the type disclosed in U.S. Pat. No. 3,355,098.
- the shortcomings of the prior art devices have been overcome by the method and apparatus of the present invention, which provide a new and improved method of collecting serum and a new and improved self-sealing, serum collection tube, and which tube may be directly filled from centrifuged specimen tubes with collected blood serum.
- the new serum collection tube basically comprises a hollow cylinder whose ends are closed off by novel one-shot" valves, one of which also functions as a piston member.
- the valves comprise selfsealing elastomeric end caps pierced by removable hollow needles.
- FIG. 1 is a cross-sectional view of the apparatus of the present invention with its upper and lower, one-shot" valves opened in preparation for collecting a serum sample from a specimen tube;
- FlG. 2 is a cross-sectional view of the apparatus of FIG. 1 during serum collection with both valves opened;
- E10. 3 is a crosssectional view of the apparatus of the invention with the upper end of the collection tube closed off by removal of the upper needle to capture and to retain the serum sample in the collection tube prior to withdrawal of the same from the specimen tube;
- FIG. 43 is a front elevational view of the collection tube with both ends self-sealed and with the blood serum safely trapped therein in accordance with the principles of the present invention.
- FIG. 1 there is shown a conventional centrifuged specimen collection tube having a pool of serum 11 disposed above settled-out, clotted cellular material 12.
- the specimen tube advantageously may be of the so-called vacutainer" type sold by Becton-Dickinson Co. for use by medical personnel in withdrawing blood samples from patients for subsequent laboratory analysis.
- Such specimen tubes typically have inside diameters of approximately flve-eighths inch. Their lengths generally will vary depending upon the size of the volumetric samples of blood required.
- the new and improved serum collection apparatus 9 of the present invention includes an elongated cylindrical collection tube 15 which is open at its upper and lower ends. Integral annular beads or flanges l6, 17 are formed at the upper and lower ends respectively of the collection tube 15, as shown.
- the upper end of the collection tube 15 is closed off by a generally cup-shaped, elastomeric, self-sealing element 18 which is mechanically connected .to the collection tube by means of a resilient, split snap ring 19 which engages the outer surface of the element 18, as shown in H0. 1., to hold the element 18 to the flange 16.
- a resilient, split snap ring 19 which engages the outer surface of the element 18, as shown in H0. 1., to hold the element 18 to the flange 16.
- Any other'suitable mechanical means, such as threads, keys, locks, etc. may be employed in lieu of the snap ring arrangement, as should be understood.
- the upper sealing element 18 is pierced by a narrow, hollow needle 20, such as a hardened steel syringe needle, which provides communication between the inside of the tube 15 and the atmosphere.
- the needle 20 mounts a head or grippable portion 21 which is adapted to be grasped by a user to facilitate the subsequent removal of the needle 20 from the sealing element 18 after serum collection.
- the sealing element 18 and the needle 20 comprise an upper, selectively actuatable one-shot" valve.
- the upper end of the collection tube in a manner similar to the lower end, is closed off by a generally cup-shaped, elastomeric, self-sealing element.
- a resilient split, snap ring 23 or other suitable means mechanically fastens the element 22 to the flanged, lower end of the tube, as shown.
- a lower elongated, hollow needle 24, similar in construction to the aforementioned needle 20, extends through the sealing element 22 to provide communication through the lower end of the collection tube.
- the lower needle 24 mounts a grippable portion 25 which may be readily grasped to remove the needle 24 from the sealing element 22;
- the lower cup-shaped element 22 together with the needle 24 also defines a one-shot" valve, the outer diameter of which is slightly greater than the inner diameter of the tube 10.
- the sealing element 22 is able to function as a piston element when inserted in telescoping association with the specimen tube. That is to say, the cylindrical outer surfaces of the sealing element 22 are appropriately dimensioned (c.g. slightly greater than flve-eighths inch in diameter) so that the element 22 sealingly, slidingly engages the inner walls of the specimen tube when inserted therein, as shown in FIGS. 2 and 3.
- blood serum may be removed from the centrifuged specimen tube 10 and securely trapped within the collection tube 15 in the following manner.
- the lower end of the collection tube 15 is inserted into the specimen tube, as shown in FIG. 2, and plunged downwardly therein, while the upper one-shot" valve is open to the atmosphere.
- the serum will be driven by the pumplike" action of the piston 22 and up through the open needle 24 and into the collection tube 15, without disturbing the clotted matter 12.
- the upper needle 20 is removed from the self-sealing, elastomeric cap 18 by merely gripping the portion 21 and pulling outwardly thereon and then it is discarded. This closes the upper one-shot" valve and will seal off the upper end of the collection tube 15 to capture the serum collected therein, in accordance with well-known principles of physics, and in spite of the fact that the lower needle 25 is still present in the collection tube.
- the collection tube apparatus 9 is withdrawn from the specimen tube W, as shown in FIG. 3, and the collected serum M is permanently trapped in the collection tube 15 by removing the lower needle 2% by grasping and pulling outwardly on the lower gripping portion 25. This closes the lower one-shot valve to provide a completely sealed collection tube 115.
- the lower needle 24 then may be discarded and the filled tube 15 may be readily mailed to pathology laboratories for testing analysis, etc. in a suitable mailing envelope M (shown in phantom in FIG. 1).
- the sealing elements R8, 22 are advantageously made of rubber and the collection tube 15 is made from glass.
- the tube 15 has an etched labeling portion 26 integral therewith upon which suitable identifying indicia may be inscribed to ensure accurate handling.
- Apparatus for removing and trapping the upper portions of a pool of liquid contained in a specimen tube having a predetermined inner diameter comprising:
- a cylindrical tubular element open at its upper and lower ends and having an outer diameter less than said predetermined inner diameter of the specimen tube
- Lower valve means closing off the lower end of said tubular element and being adapted to communicate between said inner portions of said tubular element and the liquid in said pool,
- said lower valve means comprising a puncturable, first elastomeric sealing means and a first hollow needle extending therethrough
- said first sealing means defining a cylindrical piston head having an outer diameter slightly greater than said predetermined inner diameter of said specimen tube, whereby said piston head is adapted to make sliding, sealing contact therewith.
- said upper valve means includes a second elastomeric sealing material cover said upper end and a second hollow needle extending therethrough,
- said second elastomeric material possesses sufficient resilience and said second hollow needle is sufficiently narrow whereby up on the removal of said second needle from said second elastomeric material said upper end of the tubular member will be completely self-sealed.
- the second needle mounts a gripping means by which the second needle may be removed from said second elastomeric material.
- a mechanical means joins said second elastomeric sealing means to said upper end of the tubular member.
- said mechanical means includes a resilient snap ring
- said elastomeric sealing means comprises a generally cupshaped member
- the uppermost end of said tubular member includes an annular bead.
- a mechanical means joins said first elastomeric sealing means to said lower end of the tubular member.
- said mechanical means includes a resilient snap ring
- said elastomeric sealing means comprises a generally cupshaped member
- the uppermost end of said tubular member includes an annular bead.
- tubular member is transparent.
- tubular member is glass
- predetermined portions of said glass are etched and thereby adapted to be indicia bearing.
- a method of removing serum from a specimen tube 40 comprising the steps of:
Abstract
The disclosure relates to an apparatus and a method for removing serum from the uppermost portions of a specimen tube of centrifuged blood, in which the blood serum is disposed in a liquid pool above settled-out cellular solid materials. More particularly, the invention is directed to an easily handleable, readily mailable, collection tube closed at both ends by ''''oneshot'''' valve structures comprising self-sealing elastomeric elements pierced by hollow needles. Additionally, at least the lower valve element is definitive of a pistonlike member which is adapted to engage the inner walls of the specimen tube to pump serum therefrom.
Description
United States Patent Paul A. Brown Portsmouth, NJL;
Joseph OBrien, Teaneck, NJ.
Sept. 3, 1969 June 22, 1971 Metropolitan Pathology Laboratory, lnc. Teaneck, NJ.
Inventors Appl. No. Filed Patented Assignee BLOOD SERUM COLLECTION TUBE AND Primary Examiner-Laverne D. Geiger Assistant Examiner-Edward J. Earls Attorney-Mandeville and Schweitzer ABSTRACT: The disclosure relates to an apparatus and a method for removing serum from the uppermost portions of a specimen tube of centrifuged blood, in which the blood serum is disposed in a liquid pool above settled-out cellular solid materials. More particularly, the invention is directed to an easily handleable, readily mailable, collection tube closed at both ends by one-shot" valve structures comprising self-sealing elastomeric elements pierced by hollow needles. Additionally, at least the lower valve element is definitive of a pistonlike member which is adapted to engage the inner walls of the specimen tube to pump serum therefrom.
PATENTED JUN22 197:
(FIG. 4
INVENTORS PAU L BROW N BY JOSEPH O'BRIEN ffl ATTOR EYS BLOOD SERUM COLLECTION TUBE AND METHOD OF COLLECTION BACKGROUND OF THE INVENTION ln the examination of blood samples in pathological laboratories, it is often necessary or desirable to examine blood serum after it has been separated from the suspended cellular material, and for this purpose it is customary to subject the specimen tubes, in which the blood samples are delivered to the laboratory, to centrifuging action to cause the settling of the cells to the bottom of the specimen tube. Since many laboratories process large numbers of blood samples every day, facility of handling specimens, accuracy of labeling of specimens, and the ease of drawing ofi and retaining serum specimens are important to successful and safe operation.
Quite often, laboratory workers have experienced difficulty in efficiently removing the clear serum from centrifuged blood specimen tube, without disturbing the settled out solid material. Additionally there have been problems in maintaining with accuracy the identity of the source (patient) from which the serum was originally obtained throughout its travels from hospital to laboratory, etc.
l-leretofore, the blood serum has been removed from the specimen tube, after the blood has been centrifuged to separate the serum from the clotted cells by drawing the serum off with a conventional syringe; by pouring the serum off through tilting of the specimen tube; by use of pipettes and the like; and or by use of plungerlike apparatus of the type disclosed in U.S. Pat. No. 3,355,098.
SUMMARY OF THE PRESENT lNVENTlON The shortcomings of the prior art devices have been overcome by the method and apparatus of the present invention, which provide a new and improved method of collecting serum and a new and improved self-sealing, serum collection tube, and which tube may be directly filled from centrifuged specimen tubes with collected blood serum. The new serum collection tube basically comprises a hollow cylinder whose ends are closed off by novel one-shot" valves, one of which also functions as a piston member. The valves comprise selfsealing elastomeric end caps pierced by removable hollow needles.
For a more complete understanding of the present invention and its attendant advantages, reference should be made to the following detailed description taken in conjunction with the accompanying drawings.
DESCRIPTION OF THE DRAWINGS FIG. 1 is a cross-sectional view of the apparatus of the present invention with its upper and lower, one-shot" valves opened in preparation for collecting a serum sample from a specimen tube;
FlG. 2 is a cross-sectional view of the apparatus of FIG. 1 during serum collection with both valves opened;
E10. 3 is a crosssectional view of the apparatus of the invention with the upper end of the collection tube closed off by removal of the upper needle to capture and to retain the serum sample in the collection tube prior to withdrawal of the same from the specimen tube; and
FIG. 43 is a front elevational view of the collection tube with both ends self-sealed and with the blood serum safely trapped therein in accordance with the principles of the present invention.
DETAILED DESCRIPTION OF THE INVENTION Referring now to FIG. 1, there is shown a conventional centrifuged specimen collection tube having a pool of serum 11 disposed above settled-out, clotted cellular material 12. The specimen tube advantageously may be of the so-called vacutainer" type sold by Becton-Dickinson Co. for use by medical personnel in withdrawing blood samples from patients for subsequent laboratory analysis. Such specimen tubes typically have inside diameters of approximately flve-eighths inch. Their lengths generally will vary depending upon the size of the volumetric samples of blood required. Once drawn, blood samples are centrifuged in accordance with well-known known procedures to separate within the specimen tube 10 the serum 11 and cellular matter 12, as shown in FIG. 1.
The new and improved serum collection apparatus 9 of the present invention, includes an elongated cylindrical collection tube 15 which is open at its upper and lower ends. Integral annular beads or flanges l6, 17 are formed at the upper and lower ends respectively of the collection tube 15, as shown.
In accordance with the principles of the invention, the upper end of the collection tube 15 is closed off by a generally cup-shaped, elastomeric, self-sealing element 18 which is mechanically connected .to the collection tube by means of a resilient, split snap ring 19 which engages the outer surface of the element 18, as shown in H0. 1., to hold the element 18 to the flange 16. Any other'suitable mechanical means, such as threads, keys, locks, etc. may be employed in lieu of the snap ring arrangement, as should be understood. The upper sealing element 18 is pierced by a narrow, hollow needle 20, such as a hardened steel syringe needle, which provides communication between the inside of the tube 15 and the atmosphere. Advantageously, the needle 20 mounts a head or grippable portion 21 which is adapted to be grasped by a user to facilitate the subsequent removal of the needle 20 from the sealing element 18 after serum collection. In accordance with the principles of the invention, the sealing element 18 and the needle 20 comprise an upper, selectively actuatable one-shot" valve.
The upper end of the collection tube, in a manner similar to the lower end, is closed off by a generally cup-shaped, elastomeric, self-sealing element. A resilient split, snap ring 23 or other suitable means mechanically fastens the element 22 to the flanged, lower end of the tube, as shown. In accordance with the principles of the invention, a lower elongated, hollow needle 24, similar in construction to the aforementioned needle 20, extends through the sealing element 22 to provide communication through the lower end of the collection tube. The lower needle 24 mounts a grippable portion 25 which may be readily grasped to remove the needle 24 from the sealing element 22;
As an important aspect of the present invention, the lower cup-shaped element 22 together with the needle 24 also defines a one-shot" valve, the outer diameter of which is slightly greater than the inner diameter of the tube 10. Thus the sealing element 22 is able to function as a piston element when inserted in telescoping association with the specimen tube. That is to say, the cylindrical outer surfaces of the sealing element 22 are appropriately dimensioned (c.g. slightly greater than flve-eighths inch in diameter) so that the element 22 sealingly, slidingly engages the inner walls of the specimen tube when inserted therein, as shown in FIGS. 2 and 3.
In accordance with the invention, blood serum may be removed from the centrifuged specimen tube 10 and securely trapped within the collection tube 15 in the following manner. The lower end of the collection tube 15 is inserted into the specimen tube, as shown in FIG. 2, and plunged downwardly therein, while the upper one-shot" valve is open to the atmosphere. In accordance with well-known principles of pumps, the serum will be driven by the pumplike" action of the piston 22 and up through the open needle 24 and into the collection tube 15, without disturbing the clotted matter 12. When sufficient serum has been collected in this manner to cover the needle opening 24', the upper needle 20 is removed from the self-sealing, elastomeric cap 18 by merely gripping the portion 21 and pulling outwardly thereon and then it is discarded. This closes the upper one-shot" valve and will seal off the upper end of the collection tube 15 to capture the serum collected therein, in accordance with well-known principles of physics, and in spite of the fact that the lower needle 25 is still present in the collection tube.
Thereafter, the collection tube apparatus 9 is withdrawn from the specimen tube W, as shown in FIG. 3, and the collected serum M is permanently trapped in the collection tube 15 by removing the lower needle 2% by grasping and pulling outwardly on the lower gripping portion 25. This closes the lower one-shot valve to provide a completely sealed collection tube 115. The lower needle 24 then may be discarded and the filled tube 15 may be readily mailed to pathology laboratories for testing analysis, etc. in a suitable mailing envelope M (shown in phantom in FIG. 1).
In accordance with a more specific aspect of the invention, the sealing elements R8, 22 are advantageously made of rubber and the collection tube 15 is made from glass. The tube 15 has an etched labeling portion 26 integral therewith upon which suitable identifying indicia may be inscribed to ensure accurate handling.
It should be understood that the blood serum collection method and apparatus herein illustrated and described are intended to be representative only, as certain changes may be made therein without departing from the clear teachings of the disclosure. Accordingly, reference should be made to the following appended claims in determining the full scope of the invention.
We claim:
1. Apparatus for removing and trapping the upper portions of a pool of liquid contained in a specimen tube having a predetermined inner diameter, comprising:
a. a cylindrical tubular element open at its upper and lower ends and having an outer diameter less than said predetermined inner diameter of the specimen tube,
b. selectively actuatable upper valve means closing off said upper end of said tubular element and being adapted to provide communication between interior upper portions of said tubular element and atmosphere,
c. Lower valve means closing off the lower end of said tubular element and being adapted to communicate between said inner portions of said tubular element and the liquid in said pool,
(I. said lower valve means comprising a puncturable, first elastomeric sealing means and a first hollow needle extending therethrough,
e. said elastomeric material possessing sufficient resilience and said first hollow needle being sufficiently narrow whereby on the removal of said first needle from said elastomeric material said lower end of the tubular member will be completely self sealed, said first sealing means defining a cylindrical piston head having an outer diameter slightly greater than said predetermined inner diameter of said specimen tube, whereby said piston head is adapted to make sliding, sealing contact therewith.
The apparatus of claim 1, in which: a. said upper valve means includes a second elastomeric sealing material cover said upper end and a second hollow needle extending therethrough,
b. said second elastomeric material possesses sufficient resilience and said second hollow needle is sufficiently narrow whereby up on the removal of said second needle from said second elastomeric material said upper end of the tubular member will be completely self-sealed.
3. The apparatus of claim 2, in which:
a. the second needle mounts a gripping means by which the second needle may be removed from said second elastomeric material.
4. The apparatus of claim 2, in which:
a. a mechanical means joins said second elastomeric sealing means to said upper end of the tubular member.
5. The apparatus of claim 41, in which:
a. said mechanical means includes a resilient snap ring, and
b. said elastomeric sealing means comprises a generally cupshaped member,
c. the uppermost end of said tubular member includes an annular bead.
6. The apparatus of claim 11, in which: a. the first needle mounts a gripping means by WhlCh the first needle may be removed from said first elastomeric material.
7. The apparatus of claim 1, in which:
a. a mechanical means joins said first elastomeric sealing means to said lower end of the tubular member.
8. The apparatus of claim 7, in which:
a. said mechanical means includes a resilient snap ring,
b. said elastomeric sealing means comprises a generally cupshaped member,
c. the uppermost end of said tubular member includes an annular bead.
9. The apparatus of claim l, in which:
a. said tubular member is transparent.
10. The apparatus of claim 1, in which:
a. said tubular member is glass, and
b. predetermined portions of said glass are etched and thereby adapted to be indicia bearing.
ll. A method of removing serum from a specimen tube 40 comprising the steps of:
inserting a tubular plungerclosed off at its lower end by a pistonlike element pierced by a hollow needle into the specimen tube to drive serum upwardly therethrough and into said collection tube,
b. maintaining the upper end of said collection tube open to atmosphere while said collection is driven downwardly into said serum,
c. closing off the upper end of said collection tube from atmosphere upon termination of the downward stroke of said collection tube,
d. removing said collection tube from said specimen tube,
and
e. closing off the lower end of said collection tube by removing said needle from the lower end thereof.
Claims (10)
- 2. The apparaTus of claim 1, in which: a. said upper valve means includes a second elastomeric sealing material cover said upper end and a second hollow needle extending therethrough, b. said second elastomeric material possesses sufficient resilience and said second hollow needle is sufficiently narrow whereby up on the removal of said second needle from said second elastomeric material said upper end of the tubular member will be completely self-sealed.
- 3. The apparatus of claim 2, in which: a. the second needle mounts a gripping means by which the second needle may be removed from said second elastomeric material.
- 4. The apparatus of claim 2, in which: a. a mechanical means joins said second elastomeric sealing means to said upper end of the tubular member.
- 5. The apparatus of claim 4, in which: a. said mechanical means includes a resilient snap ring, and b. said elastomeric sealing means comprises a generally cup-shaped member, c. the uppermost end of said tubular member includes an annular bead.
- 6. The apparatus of claim 1, in which: a. the first needle mounts a gripping means by which the first needle may be removed from said first elastomeric material.
- 7. The apparatus of claim 1, in which: a. a mechanical means joins said first elastomeric sealing means to said lower end of the tubular member.
- 8. The apparatus of claim 7, in which: a. said mechanical means includes a resilient snap ring, b. said elastomeric sealing means comprises a generally cup-shaped member, c. the uppermost end of said tubular member includes an annular bead.
- 9. The apparatus of claim 1, in which: a. said tubular member is transparent.
- 10. The apparatus of claim 1, in which: a. said tubular member is glass, and b. predetermined portions of said glass are etched and thereby adapted to be indicia bearing.
- 11. A method of removing serum from a specimen tube comprising the steps of: inserting a tubular plunger closed off at its lower end by a pistonlike element pierced by a hollow needle into the specimen tube to drive serum upwardly therethrough and into said collection tube, b. maintaining the upper end of said collection tube open to atmosphere while said collection is driven downwardly into said serum, c. closing off the upper end of said collection tube from atmosphere upon termination of the downward stroke of said collection tube, d. removing said collection tube from said specimen tube, and e. closing off the lower end of said collection tube by removing said needle from the lower end thereof.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US85498269A | 1969-09-03 | 1969-09-03 |
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US3586064A true US3586064A (en) | 1971-06-22 |
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US854982A Expired - Lifetime US3586064A (en) | 1969-09-03 | 1969-09-03 | Blood serum collection tube and method of collection |
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Cited By (61)
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US3719410A (en) * | 1971-11-10 | 1973-03-06 | Farrand Optical Co Inc | Mixing and measuring apparatus |
US3771965A (en) * | 1971-04-23 | 1973-11-13 | R Grams | Biological fluid sampling apparatus |
US3782548A (en) * | 1972-12-07 | 1974-01-01 | J Bowen | Serum skimmer |
US3799342A (en) * | 1970-07-27 | 1974-03-26 | Medical Res & Dev Inc | Method of using a serum separator |
US3814248A (en) * | 1971-09-07 | 1974-06-04 | Corning Glass Works | Method and apparatus for fluid collection and/or partitioning |
US3814258A (en) * | 1973-03-15 | 1974-06-04 | Dickinson And Co | Blood plasma separator with filter |
US3814079A (en) * | 1972-04-28 | 1974-06-04 | Upjohn Co | Liquid collecting and filtering device |
US3853011A (en) * | 1972-06-14 | 1974-12-10 | H Baumann | Method and apparatus for the suction removal of a liquid |
US3873449A (en) * | 1973-04-05 | 1975-03-25 | Baxter Laboratories Inc | Filter skimming apparatus |
US3882021A (en) * | 1974-02-27 | 1975-05-06 | Becton Dickinson Co | Sealed assembly for separation of blood with anti-red cell barrier |
US3891553A (en) * | 1974-02-27 | 1975-06-24 | Becton Dickinson Co | Serum and plasma separator {13 {0 constrictionless type |
US3905528A (en) * | 1974-04-10 | 1975-09-16 | Hugh V Maiocco | Two-piece concentric centrifuge sample container |
US3920557A (en) * | 1974-02-27 | 1975-11-18 | Becton Dickinson Co | Serum/plasma separator--beads-plus-adhesive type |
US3932277A (en) * | 1974-03-29 | 1976-01-13 | Bio-Logics Products, Inc. | Method and apparatus for separating blood fractions |
FR2276590A1 (en) * | 1974-06-24 | 1976-01-23 | Mediplast Ab | DEVICE FOR TRANSFERRING BLOOD OR SIMILAR FLUID INTO A PIPETTE |
US3941699A (en) * | 1974-02-27 | 1976-03-02 | Becton, Dickinson And Company | Plasma separator with centrifugal valve |
US3955423A (en) * | 1972-09-18 | 1976-05-11 | Marvin Padover | Liquid sampling method |
US4022576A (en) * | 1975-06-09 | 1977-05-10 | I. C. L. Scientific | Method and apparatus for preparation of liquids containing suspended material for examination |
US4057499A (en) * | 1973-03-09 | 1977-11-08 | Buono Frank S | Apparatus and method for separation of blood |
US4119125A (en) * | 1977-06-22 | 1978-10-10 | Elkins Carlos D | Method and apparatus for handling liquid samples |
US4142668A (en) * | 1976-10-01 | 1979-03-06 | Lee Jae Y | Serum-plasma separator and transfer apparatus |
US4197735A (en) * | 1978-11-06 | 1980-04-15 | Chase Instruments Corporation | Blood sedimentation rate test means |
US4209488A (en) * | 1978-10-10 | 1980-06-24 | Owens-Illinois, Inc. | Fluid collection apparatus |
US4210623A (en) * | 1978-05-01 | 1980-07-01 | Owens-Illinois, Inc. | Fluid collection apparatus |
US4234317A (en) * | 1979-05-24 | 1980-11-18 | Analytical Products, Inc. | Apparatus and method for fractionation of lipoproteins |
FR2471204A1 (en) * | 1979-12-12 | 1981-06-19 | Michael Cais | METHOD AND DEVICE FOR TRANSFERRING MASS OF AT LEAST ONE COMPONENT FROM A LIQUID PHASE TO ANOTHER LIQUID PHASE WITH SEPARATION OF THESE TWO PHASES IN THIS SAME DEVICE |
DE3001409A1 (en) * | 1980-01-16 | 1981-08-06 | Rostislav Dr. 7910 Neu-Ulm Caletka | Conical connection between syringe cylinder and outlet - for sepn. of immiscible liquids |
US4305303A (en) * | 1980-02-19 | 1981-12-15 | Texaco Inc. | Sampling device and methods for collecting a lighter medium floating on a heavier medium |
US4346608A (en) * | 1980-07-31 | 1982-08-31 | The United States Of America As Represented By The Secretary Of The Army | Float device for density gradient fractionation |
US4487696A (en) * | 1978-08-14 | 1984-12-11 | Ferrara Louis T | Blood separator and dispenser |
US4644807A (en) * | 1985-02-21 | 1987-02-24 | Dionex Corporation | Fluid sample delivery apparatus |
DE9013914U1 (en) * | 1990-10-05 | 1991-02-14 | Walter Sarstedt Geraete Und Verbrauchsmaterial Fuer Medizin Und Wissenschaft, 5223 Nuembrecht, De | |
US5257529A (en) * | 1990-12-28 | 1993-11-02 | Nissho Corporation | Method and device for measurement of viscosity of liquids |
US5340546A (en) * | 1993-04-05 | 1994-08-23 | David Bromley | Gas filter |
US5393494A (en) * | 1992-05-28 | 1995-02-28 | Diasys Corporation | Apparatus for drawing fluid sample, components thereof, and slide assembly for use therewith |
US5552064A (en) * | 1993-02-26 | 1996-09-03 | Ortho Diagnostic Systems, Inc. | Column agglutination assay and device using biphasic centrifugation |
US5855852A (en) * | 1995-04-01 | 1999-01-05 | Boehringer Mannheim Gmbh | Vessel for reducing contamination in the treatment of liquids |
US5919356A (en) * | 1994-12-24 | 1999-07-06 | Fsm Technologies Ltd. | Fluid sampling device |
US5968018A (en) * | 1996-10-30 | 1999-10-19 | Cohesion Corporation | Cell separation device and in-line orifice mixer system |
US5997811A (en) * | 1997-07-02 | 1999-12-07 | Cohesion Technologies, Inc. | Method for sterile syringe packaging and handling |
US6132353A (en) * | 1996-10-21 | 2000-10-17 | Winkelman; James W. | Apparatus and method for separating plasma or serum from the red cells of a blood sample |
US20020072703A1 (en) * | 2000-07-18 | 2002-06-13 | Peter Nollert | Method and apparatus for preparing lipidic mesophase material |
US20020160443A1 (en) * | 1998-05-09 | 2002-10-31 | Ikonisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
WO2003028844A1 (en) * | 2001-10-04 | 2003-04-10 | Ikonisys, Inc. | System and method for fractionation of a centrifuged sample |
US20030175167A1 (en) * | 2002-03-18 | 2003-09-18 | Arai Takanori | Apparatus for separating biological sample and separating method of the same |
US20040171937A1 (en) * | 2002-09-23 | 2004-09-02 | Scimed Life Systems, Inc. | Systems and methods for flushing catheters |
US20060196885A1 (en) * | 2005-02-21 | 2006-09-07 | Biomet Manufacturing Corp. | Method and apparatus for application of a fluid |
US20080206774A1 (en) * | 1998-05-09 | 2008-08-28 | Ikonisys, Inc. | Automated cancer diagnostic methods using fish |
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US20090111101A1 (en) * | 1998-05-09 | 2009-04-30 | Ikonisys, Inc. | Automated Cancer Diagnostic Methods Using FISH |
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US20100081166A1 (en) * | 2008-09-30 | 2010-04-01 | Tyco Healthcare Group Lp | Microbial Detection Assembly |
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US8182769B2 (en) | 2008-04-04 | 2012-05-22 | Biomet Biologics, Llc | Clean transportation system |
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US20160167061A1 (en) * | 2014-12-15 | 2016-06-16 | Akadeum Life Sciences, LLC | Method and system for buoyant separation |
US20170292102A1 (en) * | 2016-04-06 | 2017-10-12 | Corning Incorporated | Packaging and transfer system for microcarriers |
US20200009304A1 (en) * | 2018-07-09 | 2020-01-09 | Hanuman Pelican, Inc. | Apparatus and methods for processing blood |
US11291931B2 (en) | 2014-12-15 | 2022-04-05 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
US11583893B2 (en) | 2018-07-09 | 2023-02-21 | Akadeum Life Sciences, Inc. | System and method for buoyant particle processing |
US11819842B2 (en) | 2021-08-26 | 2023-11-21 | Akadeum Life Sciences, Inc. | Method and system for buoyant separation |
-
1969
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US3799342A (en) * | 1970-07-27 | 1974-03-26 | Medical Res & Dev Inc | Method of using a serum separator |
US3771965A (en) * | 1971-04-23 | 1973-11-13 | R Grams | Biological fluid sampling apparatus |
US3814248A (en) * | 1971-09-07 | 1974-06-04 | Corning Glass Works | Method and apparatus for fluid collection and/or partitioning |
US3719410A (en) * | 1971-11-10 | 1973-03-06 | Farrand Optical Co Inc | Mixing and measuring apparatus |
US3814079A (en) * | 1972-04-28 | 1974-06-04 | Upjohn Co | Liquid collecting and filtering device |
US3853011A (en) * | 1972-06-14 | 1974-12-10 | H Baumann | Method and apparatus for the suction removal of a liquid |
US3955423A (en) * | 1972-09-18 | 1976-05-11 | Marvin Padover | Liquid sampling method |
US3782548A (en) * | 1972-12-07 | 1974-01-01 | J Bowen | Serum skimmer |
US4057499A (en) * | 1973-03-09 | 1977-11-08 | Buono Frank S | Apparatus and method for separation of blood |
US3814258A (en) * | 1973-03-15 | 1974-06-04 | Dickinson And Co | Blood plasma separator with filter |
US3873449A (en) * | 1973-04-05 | 1975-03-25 | Baxter Laboratories Inc | Filter skimming apparatus |
US3941699A (en) * | 1974-02-27 | 1976-03-02 | Becton, Dickinson And Company | Plasma separator with centrifugal valve |
US3920557A (en) * | 1974-02-27 | 1975-11-18 | Becton Dickinson Co | Serum/plasma separator--beads-plus-adhesive type |
US3882021A (en) * | 1974-02-27 | 1975-05-06 | Becton Dickinson Co | Sealed assembly for separation of blood with anti-red cell barrier |
US3891553A (en) * | 1974-02-27 | 1975-06-24 | Becton Dickinson Co | Serum and plasma separator {13 {0 constrictionless type |
US3932277A (en) * | 1974-03-29 | 1976-01-13 | Bio-Logics Products, Inc. | Method and apparatus for separating blood fractions |
US3905528A (en) * | 1974-04-10 | 1975-09-16 | Hugh V Maiocco | Two-piece concentric centrifuge sample container |
FR2276590A1 (en) * | 1974-06-24 | 1976-01-23 | Mediplast Ab | DEVICE FOR TRANSFERRING BLOOD OR SIMILAR FLUID INTO A PIPETTE |
US4022576A (en) * | 1975-06-09 | 1977-05-10 | I. C. L. Scientific | Method and apparatus for preparation of liquids containing suspended material for examination |
US4142668A (en) * | 1976-10-01 | 1979-03-06 | Lee Jae Y | Serum-plasma separator and transfer apparatus |
US4119125A (en) * | 1977-06-22 | 1978-10-10 | Elkins Carlos D | Method and apparatus for handling liquid samples |
US4210623A (en) * | 1978-05-01 | 1980-07-01 | Owens-Illinois, Inc. | Fluid collection apparatus |
US4487696A (en) * | 1978-08-14 | 1984-12-11 | Ferrara Louis T | Blood separator and dispenser |
US4209488A (en) * | 1978-10-10 | 1980-06-24 | Owens-Illinois, Inc. | Fluid collection apparatus |
WO1980000923A1 (en) * | 1978-11-06 | 1980-05-15 | R Munzer | Blood sedimentation rate test means |
US4197735A (en) * | 1978-11-06 | 1980-04-15 | Chase Instruments Corporation | Blood sedimentation rate test means |
US4234317A (en) * | 1979-05-24 | 1980-11-18 | Analytical Products, Inc. | Apparatus and method for fractionation of lipoproteins |
FR2471204A1 (en) * | 1979-12-12 | 1981-06-19 | Michael Cais | METHOD AND DEVICE FOR TRANSFERRING MASS OF AT LEAST ONE COMPONENT FROM A LIQUID PHASE TO ANOTHER LIQUID PHASE WITH SEPARATION OF THESE TWO PHASES IN THIS SAME DEVICE |
DE3001409A1 (en) * | 1980-01-16 | 1981-08-06 | Rostislav Dr. 7910 Neu-Ulm Caletka | Conical connection between syringe cylinder and outlet - for sepn. of immiscible liquids |
US4305303A (en) * | 1980-02-19 | 1981-12-15 | Texaco Inc. | Sampling device and methods for collecting a lighter medium floating on a heavier medium |
US4346608A (en) * | 1980-07-31 | 1982-08-31 | The United States Of America As Represented By The Secretary Of The Army | Float device for density gradient fractionation |
US4644807A (en) * | 1985-02-21 | 1987-02-24 | Dionex Corporation | Fluid sample delivery apparatus |
DE9013914U1 (en) * | 1990-10-05 | 1991-02-14 | Walter Sarstedt Geraete Und Verbrauchsmaterial Fuer Medizin Und Wissenschaft, 5223 Nuembrecht, De | |
US5257529A (en) * | 1990-12-28 | 1993-11-02 | Nissho Corporation | Method and device for measurement of viscosity of liquids |
US5393494A (en) * | 1992-05-28 | 1995-02-28 | Diasys Corporation | Apparatus for drawing fluid sample, components thereof, and slide assembly for use therewith |
US5552064A (en) * | 1993-02-26 | 1996-09-03 | Ortho Diagnostic Systems, Inc. | Column agglutination assay and device using biphasic centrifugation |
US5650068A (en) * | 1993-02-26 | 1997-07-22 | Ortho Diagnostic Systems Inc. | Column agglutination assay and device using biphasic centrifugation |
US5340546A (en) * | 1993-04-05 | 1994-08-23 | David Bromley | Gas filter |
US5919356A (en) * | 1994-12-24 | 1999-07-06 | Fsm Technologies Ltd. | Fluid sampling device |
US5855852A (en) * | 1995-04-01 | 1999-01-05 | Boehringer Mannheim Gmbh | Vessel for reducing contamination in the treatment of liquids |
US6132353A (en) * | 1996-10-21 | 2000-10-17 | Winkelman; James W. | Apparatus and method for separating plasma or serum from the red cells of a blood sample |
US6398705B1 (en) * | 1996-10-21 | 2002-06-04 | Manfred Grumberg | Apparatus for separating plasma or serum from the red cells with a blood sample |
US5968018A (en) * | 1996-10-30 | 1999-10-19 | Cohesion Corporation | Cell separation device and in-line orifice mixer system |
US5997811A (en) * | 1997-07-02 | 1999-12-07 | Cohesion Technologies, Inc. | Method for sterile syringe packaging and handling |
US7901887B2 (en) | 1998-05-09 | 2011-03-08 | Ikonisys, Inc. | Automated cancer diagnostic methods using fish |
US20020160443A1 (en) * | 1998-05-09 | 2002-10-31 | Ikonisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
US20090111101A1 (en) * | 1998-05-09 | 2009-04-30 | Ikonisys, Inc. | Automated Cancer Diagnostic Methods Using FISH |
US7945391B2 (en) | 1998-05-09 | 2011-05-17 | Iknonisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
US20080241848A1 (en) * | 1998-05-09 | 2008-10-02 | Ikonisys, Inc. | Methods for prenatal diagnosis of aneuploidy |
US20080206774A1 (en) * | 1998-05-09 | 2008-08-28 | Ikonisys, Inc. | Automated cancer diagnostic methods using fish |
US7640112B2 (en) | 1998-05-09 | 2009-12-29 | Ikenisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
US7835869B2 (en) | 1998-05-09 | 2010-11-16 | Ikonisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
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US20060068377A1 (en) * | 1998-05-09 | 2006-03-30 | Ikonisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
US20060068375A1 (en) * | 1998-05-09 | 2006-03-30 | Ikonisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
US20060078877A1 (en) * | 1998-05-09 | 2006-04-13 | Ikonisys, Inc. | Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis |
US6821487B2 (en) * | 2000-07-18 | 2004-11-23 | Regents Of The University Of California | Method and apparatus for preparing lipidic mesophase material |
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US7323144B2 (en) * | 2002-03-18 | 2008-01-29 | Leisure, Inc. | Apparatus for separating biological sample and separating method of the same |
US20030175167A1 (en) * | 2002-03-18 | 2003-09-18 | Arai Takanori | Apparatus for separating biological sample and separating method of the same |
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US7819848B2 (en) | 2002-09-23 | 2010-10-26 | Boston Scientific Scimed, Inc. | Systems and methods for flushing catheters |
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