US3564256A - Radioisotope generator of the mother-daughter type having quick-detachable members - Google Patents

Radioisotope generator of the mother-daughter type having quick-detachable members Download PDF

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Publication number
US3564256A
US3564256A US3564256DA US3564256A US 3564256 A US3564256 A US 3564256A US 3564256D A US3564256D A US 3564256DA US 3564256 A US3564256 A US 3564256A
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United States
Prior art keywords
holder
vessel
quick
fluid
coupling
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Expired - Lifetime
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English (en)
Inventor
Jan Jacob Ariman
Dirk Nonhebel
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MAALLINCKRODT DIAGNOSTICA (HOLLAND) BV WESTERDUINWEG 3 1755 LE PETTEN NETHERLANDS
US Philips Corp
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US Philips Corp
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Publication of US3564256A publication Critical patent/US3564256A/en
Assigned to MAALLINCKRODT DIAGNOSTICA (HOLLAND) B.V., WESTERDUINWEG 3, 1755 LE PETTEN, THE NETHERLANDS reassignment MAALLINCKRODT DIAGNOSTICA (HOLLAND) B.V., WESTERDUINWEG 3, 1755 LE PETTEN, THE NETHERLANDS CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). EFFECTIVE DATE: SEPTEMBER 3, 1984 Assignors: BYK-MALLINCKRODT CIL B.V.
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Expired - Lifetime legal-status Critical Current

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Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L29/00—Joints with fluid cut-off means
    • F16L29/005—Joints with fluid cut-off means joints with cut-off devices which can be perforated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21F—PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT; TREATING RADIOACTIVELY CONTAMINATED MATERIAL; DECONTAMINATION ARRANGEMENTS THEREFOR
    • G21F7/00—Shielded cells or rooms
    • G21F7/06—Structural combination with remotely-controlled apparatus, e.g. with manipulators
    • G21F7/068—Remotely manipulating devices for fluids
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00—Radioactive sources
    • G21G4/04—Radioactive sources other than neutron sources
    • G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08—Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/2013—Piercing means having two piercing ends
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/0005—Isotope delivery systems

Definitions

  • a vessel for a flushing liquid is connected with the upper coupling portion and the vessel for the fluid to be collected is connected with the lower coupling member portion to facilitate washing of the holder and collection of the fluid from the holder while avoiding contamination ofthe fluid in the holder.
  • the invention relates to a device comprising a detachable holder for a substance having radioactive constituents, into which holder, in operation, a washing fluid is introduced at the upper end, while a fluid containing radioactive constituents, particularly suitable for medical purposes is obtained from the lower end of said holder and collected in a vessel.
  • the holder may contain a radioactive mother substance bound, for example, to an ion exchanger, for instance molybdenum-99 or germanium-68, which decays with time by radiation into a radioactive daughter substance having a shorter half-value period than the mother substance, for example, Technicium-99m or gallium-68.
  • ion exchanger for instance molybdenum-99 or germanium-68
  • a radioactive daughter substance having a shorter half-value period than the mother substance, for example, Technicium-99m or gallium-68.
  • These daughter substances suitable for various medical purposes. They may be injected as liquid suspensions into the blood vessels of the human body, where they provide by their radiation measurable data about physical procedures and conditions of body organs.
  • the desired product of the device formed by a fluid having the daughter substance is obtained.
  • a known device of this kind comprises a holder with the mother substance, also termed the generator, which holder is open at the bottom and whose closure at the top is removed for introducing the washing fluid. Beneath the holder an open vessel is arranged. In operation the holder and the vessel of that device are usually screened at least partly, for example by a lead jacket. During the washing operation, that is to say, when the flush is poured in and the product is collected, the upper end and the lower end of the holder and also the collecting vessel remain open.
  • This known device has the advantage that it allows quick manipulation, which is important for avoiding a noxious effect of the radiation on the operator or persons standing by. This advantage is particularly appreciated in preparing the device for operation, for example, when the generator is taken out of its packing and introduced into the device and during the washing operation itself.
  • the product of the device has to fulfill, because of its medical use, the requirements of being sterile and pyrogenfree.
  • the known device has the disadvantage that it cannot fulfill this requirement without the need for further steps. Since the holder and the collecting vessel are open during the washing operation, infecting substances are freely accessible to the product. it is therefore necessary to subject the product of this known device to a sterilizing treatment before use. This may be particularly disadvantageous, when the half-value period of the radioactive product is only little longer than the period of time required for sterilization. It is even not possible to use for medical purposes the radioactivity of the eluates obtained by the known device, if these eluates have a half-value period approximately equal to or shorter than the required period of sterilization. 1
  • the invention has for its object to provide a device for obtaining fluids containing radioactive constituents particularly suitable for medical purposes, by which the disadvantages of the known device described can be avoided and the said advantages are maintained.
  • a device of the kind set forth according to the invention is characterized in that the holder is provided at the upper end and at the lower end with a portion of a quick-coupling member, while in operation a vessel for the flushing liquid is connected with the upper coupling member portion and the vessel for the fluid to be collected is connected with the lower coupling member portion.
  • a further advantage of the device according to the invention consists in that during washing the holder and the vessels communicate with each other, so that the fluids and the contents of the holder are not accessible for particles from the environments. This means that, it being assumed that the conventional steps are taken such as the use of presterilized, pyrogen-free washing fluid, vessels and coupling members, the device can provide from a sterile, pyrogen-free generator a sterile and pyrogen-free product directly suitable for medical use. Subsequent sterilization of the product may be dispensed with. Even daughter. substances having a very short half-value period may be employed.
  • One embodiment of the device according to the invention is characterized in that a portion of the holder coupling member is formed by a pierceable wall portion of the holder and a coupling portion that can be connected herewith is formed by a hollow needle.
  • the pierceable wall portion may be formed by a rubber plug, arranged on the holder, for example, of glass and sealed at the edge by a flanged capsule.
  • the needle may be an injection needle.
  • a coupling portion adapted to be connected with a coupling portion of the holder is fastened to the end wall of an approximately box-shaped element, which is open at one end and surrounds the holder at least partly with small clearance in the operation of the device.
  • the box-shaped element previously sterilized in the conventional manner, may be fastened in or inserted into the device (for example through an opening of a lead jacket), after which the generator can be simply inserted into this element, while at the same time the connection of the coupling concerned can be rapidly established.
  • the device according to the invention may be furthermore characterized in that in operation the holder is surrounded by two box-shaped elements, which surround the holder with a slight amount of clearance and fit one in the other and, if any, in a screening jacket of the device, each element having a coupling portion adapted to be connected with a coupling portion of the holder. It is thus possible to connect the two sides of the holder rapidly with the elements, while the second box-shaped element is slipped onto the first element like a lid.
  • An advantageous embodiment'of the device according to the invention is characterized in that a connection between a vessel and a coupling portion adapted to be connected with a holder coupling includes a further detachable coupling member, a first portion of which is fastened to the vessel and a second portion to the coupling portion adapted to be connected with the holder. It is thus possible to handle a vessel and a box-shaped element as separate parts. They may therefore be sterilized separately, but the particular advantage of this embodiment resides in that the sterile quick connections of the holder once established need not be interrupted for the whole lifetime of the mother substance. During this period of time, in which the generator may be repeatedly washed, the box-shaped elements, if provided, remain in the device, while the vessels for the washing fluid and the product can be replaced according to need after each washing operation or more frequently.
  • a further connection between a quick-coupling member for the holder and a vessel may be established by means of a readily sterilizable coupling member, preferably a quickcoupling member known from the medical instrument technology.
  • the device according to the invention is characterized in that a coupling portion fastened to a vessel is formed by a pierceable wall portion of the vessel, while the coupling portion to be connected therewith is formed by a hollow needle. For withdrawing the air from the vessel a second hollow needle may be pierced through said wall portion of the vessel.
  • the vessel need not be freed of air.
  • This embodiment is characterized in that the vessel is substantially cylindrical and accommodates a movable piston.
  • the vessel and the holder of the resultant device form a closed system, into which no air need be introduced above the washing fluid and from which no air need be removed from the collecting vessel.
  • This device approaches therefore very closely the ideal of a perfectly sterile product.
  • a vessel with a piston cal syringe A vessel with a piston cal syringe.
  • the device in the position shown the device is provided with the holder having the substance containing radioactive constituents and the vessels for the washing fluid and the product to be collected.
  • the holder 1 of the device may contain a radioactive mother substance, such as molybdenum-99 or germanium-68, bound to an ion exchanger, formed for example by given resins or aluminum oxide.
  • the binder and the mother substance are designated by 2; they are provided in the holder 1 above a filter 3.
  • the holder 1, which is cylindrical in this embodiment, may be made of glass and has an opening at the upper and the lower ends, closed by rubber plugs 4. The edges of the plugs 4 are furthermore sealed by flanged capsules 5, which leave the center of the plugs 4 uncovered.
  • the holder 1 is surrounded by two box-shaped elements 6 fitting one in the other and around the holder with a small clearance.
  • the cylindrical elements 6 are open at one end and have a prolongation 8 at the end walls 7 at the opposite ends.
  • the ends of the prolongations 8 have a portion 9 of a mechanical quick-coupling member which by means of a screw thread is detachable.
  • the portions 9 form at the same time the settings for the hollow needles 10, which may be soldered in said portions 9.
  • the vessels 11 and 12 comprise each a cylindrical body 13, for example, of glass, to which rings 14 are cemented.
  • the lids 15 join the rings 14.
  • the other ends of the vessels [1 and 12 are closed by lids 16.
  • Through openings in the lids 15 emerge the piston rods 17 of the pistons 18.
  • the lids 16 comprise the portions 19 of a mechanical quick-coupling member, which are attached in the position shown to said portions 9 of said coupling member.
  • the vessel 11 contains a washing fluid 20, which may be a physiological salt solution.
  • the holder l and the elements 6 are largely surrounded by a screening jacket 21, for example, of lead. Through the screening jacket 21 bolts 22 are taken for clamping the elements 6 in the jacket 21.
  • the jacket 21 is closed at the upper end by lids 23, for example, of lead.
  • the vessel 12 for collecting the radioactive fluid is surrounded by a screening formed by a cylindrical jacket 24, cut into halves in the longitudinal direction, these halves being held in place by a tube 25, slipped around them and closed by a lid 26.
  • the jacket 24, the tube 25 and the lid 26 may also be made of lead.
  • the vessels 11 and 12 may be formed by conventional medical syringes of adequate capacities, for example 30 or 50 mls.
  • the screening jacket 21 bears on a support 27, having an upper plate 28, columns 29 and a base plate 30.
  • the device is operated as follows.
  • the holder, closed by the may be formed by the body ofa mediplugs 5, is introduced into the sterilized lower elements 6. arranged previously in the jacket 21, while the lower plug is pierced by the lower needle 10.
  • the lower coupling portion 9 may be closed by a suitable plug.
  • the upper element 6 with its needle 10 and the coupling portion 9 is arranged in place, after which the lids 23 are arranged.
  • the two plugs 5 of the holder 1 are then pierced by the needles 10.
  • the upper coupling portion 9 may be closed by a fitting plug.
  • the elements 6 can be fixed in place by means of the bolts 22.
  • the vessels 12 and 11 are connected; the vessel 12 in the empty state while the pistitfindlflpg l e W1 this vessel is in the upper position and the vessel 1 the washing fluid 20 beneath the piston 18 of this vessel.
  • the washing operation starts.
  • a slight pressure may be exerted on the upper piston rod 17, for example, by means of a weight.
  • the piston 18 of the vessel 11 has to be readily movable in the cylinder of this vessel.
  • the fluid 20 flows through the holder 1, while the radioactive mother substance remains bound to the binder, but the radioactive eluate is carried along downwards through the filter 3 to the collecting vessel 12.
  • the vessels 11 and 12 and the holder 1 form, during the washing operation, a closed system into which no air is allowed to enter and from which no air need be withdrawn. In this manner such a sterile, pyrogen-free fluid with a radioactive daughter substance is collected in the vessel 12 that subsequent sterilization is no longer required.
  • a device for obtaining fluids containing radioactive constituents particularly suitable for medical purposes comprising a detachable holder closed at its upper and lower end by a pierceable wall, a pair of interfitting box-shaped members surrounding said holder, each of said box-shaped members having a prolongation which is provided with a first part of a quick-coupling means, said first part for each prolongation carrying a hollow needle which protrudes into said pierceable wall during operation of said device, a vessel for containing washing fluid having a second part of said quick-coupling means to be connected with the first part of said quickcoupling means at the upper side of the holder, and a vessel for the fluid to be collected having a second part of said quickcoupling means at the lower side of the holder.
  • each vessel has a substantially cylindrical shape and accommodates a moveable piston.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Lining Or Joining Of Plastics Or The Like (AREA)
US3564256D 1966-06-03 1967-06-01 Radioisotope generator of the mother-daughter type having quick-detachable members Expired - Lifetime US3564256A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6607699A NL6607699A (da) 1966-06-03 1966-06-03

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US3564256A true US3564256A (en) 1971-02-16

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US3564256D Expired - Lifetime US3564256A (en) 1966-06-03 1967-06-01 Radioisotope generator of the mother-daughter type having quick-detachable members

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US (1) US3564256A (da)
BE (1) BE699446A (da)
DE (1) DE1566539A1 (da)
DK (1) DK117913B (da)
FI (1) FI47266C (da)
FR (1) FR1583657A (da)
GB (1) GB1186587A (da)
NL (1) NL6607699A (da)
NO (1) NO123969B (da)
SE (1) SE344278B (da)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710118A (en) * 1970-05-25 1973-01-09 Mallinckrodt Chemical Works Radioisotope generator
US3740558A (en) * 1971-02-17 1973-06-19 Dainabot Radioisotope Labor Lt Radioactive isotope generator of short-lived nuclides
DE2421530A1 (de) * 1973-05-04 1974-11-21 Squibb & Sons Inc Generator zum erzeugen radioaktiver substanzen
US4387303A (en) * 1979-03-26 1983-06-07 Byk-Mallinckrodt Cil B.V. Radioisotope generator
EP0117752A2 (en) * 1983-02-28 1984-09-05 E.R. Squibb & Sons, Inc. Strontium-Rubidium Infusion System
US4472299A (en) * 1981-04-24 1984-09-18 Amersham International Plc Generator for radionuclide and process of use thereof
US4495150A (en) * 1983-07-25 1985-01-22 Beckman Instruments, Inc. Multiple object capturing and processing device
EP0160303A2 (en) * 1983-02-28 1985-11-06 E.R. Squibb & Sons, Inc. Strontium-rubidium infusion system
EP0586368A1 (de) * 1992-08-28 1994-03-09 CREMISA Medizintechnik GmbH Nuklidgenerator
WO1995023576A1 (fr) * 1994-03-04 1995-09-08 Pasteur Merieux Serums Et Vaccins Ensemble pour la repartition d'une solution pharmaceutique dans des carpules ou analogues, notamment apres reprise d'un produit lyophilise
US6366633B1 (en) * 1998-08-03 2002-04-02 Eurotope Entwicklungsgesellschaft für Isotopentechnologien mbh Storage and dispatch container for radioactive miniature radiation sources
WO2003081055A1 (en) * 2002-03-20 2003-10-02 Amersham Plc Component support and radioisotope generator including one or more component supports
WO2003088269A2 (en) * 2002-04-11 2003-10-23 Amersham Plc Radioisotope generator and method of construction thereof
US20050116186A1 (en) * 2002-04-11 2005-06-02 Weisner Peter S. Radioisotope generator
US20060286004A1 (en) * 2005-06-15 2006-12-21 Jacobs Merrit N Containers for reducing or eliminating foaming

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL165321C (nl) * 1971-03-02 1981-03-16 Byk Mallinckrodt Cil Bv Werkwijze voor de vervaardiging van een radio-isotopen producerende generator.
DE3531355A1 (de) * 1985-09-03 1987-03-12 Hoechst Ag Technetium-99m-generator, seine herstellung und verwendung
US5633900A (en) * 1993-10-04 1997-05-27 Hassal; Scott B. Method and apparatus for production of radioactive iodine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3156532A (en) * 1961-06-30 1964-11-10 Robert F Doering Yttrium-90 generator
US3446965A (en) * 1966-08-10 1969-05-27 Mallinckrodt Chemical Works Generation and containerization of radioisotopes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3156532A (en) * 1961-06-30 1964-11-10 Robert F Doering Yttrium-90 generator
US3446965A (en) * 1966-08-10 1969-05-27 Mallinckrodt Chemical Works Generation and containerization of radioisotopes

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710118A (en) * 1970-05-25 1973-01-09 Mallinckrodt Chemical Works Radioisotope generator
US3740558A (en) * 1971-02-17 1973-06-19 Dainabot Radioisotope Labor Lt Radioactive isotope generator of short-lived nuclides
DE2421530A1 (de) * 1973-05-04 1974-11-21 Squibb & Sons Inc Generator zum erzeugen radioaktiver substanzen
US4387303A (en) * 1979-03-26 1983-06-07 Byk-Mallinckrodt Cil B.V. Radioisotope generator
US4472299A (en) * 1981-04-24 1984-09-18 Amersham International Plc Generator for radionuclide and process of use thereof
EP0117752A3 (en) * 1983-02-28 1986-02-26 E.R. Squibb & Sons, Inc. Dosimetry system for strontium-rubidium infusion pump
EP0160303A2 (en) * 1983-02-28 1985-11-06 E.R. Squibb & Sons, Inc. Strontium-rubidium infusion system
EP0160303A3 (en) * 1983-02-28 1986-03-05 E.R. Squibb & Sons, Inc. Strontium-rubidium infusion system
EP0117752A2 (en) * 1983-02-28 1984-09-05 E.R. Squibb & Sons, Inc. Strontium-Rubidium Infusion System
US4495150A (en) * 1983-07-25 1985-01-22 Beckman Instruments, Inc. Multiple object capturing and processing device
EP0586368A1 (de) * 1992-08-28 1994-03-09 CREMISA Medizintechnik GmbH Nuklidgenerator
WO1995023576A1 (fr) * 1994-03-04 1995-09-08 Pasteur Merieux Serums Et Vaccins Ensemble pour la repartition d'une solution pharmaceutique dans des carpules ou analogues, notamment apres reprise d'un produit lyophilise
US6366633B1 (en) * 1998-08-03 2002-04-02 Eurotope Entwicklungsgesellschaft für Isotopentechnologien mbh Storage and dispatch container for radioactive miniature radiation sources
US7060998B2 (en) * 2002-03-20 2006-06-13 Ge Healthcare Limited Component support and radioisotope generator including one or more component supports
WO2003081055A1 (en) * 2002-03-20 2003-10-02 Amersham Plc Component support and radioisotope generator including one or more component supports
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Also Published As

Publication number Publication date
NO123969B (da) 1972-02-07
FR1583657A (da) 1969-11-28
DK117913B (da) 1970-06-15
SE344278B (da) 1972-04-10
FI47266C (fi) 1973-11-12
GB1186587A (en) 1970-04-02
NL6607699A (da) 1967-12-04
BE699446A (da) 1967-12-04
DE1566539A1 (de) 1970-04-30
FI47266B (da) 1973-07-31

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