US3539643A - Polyene compounds - Google Patents
Polyene compounds Download PDFInfo
- Publication number
- US3539643A US3539643A US609312A US3539643DA US3539643A US 3539643 A US3539643 A US 3539643A US 609312 A US609312 A US 609312A US 3539643D A US3539643D A US 3539643DA US 3539643 A US3539643 A US 3539643A
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- United States
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- solution
- compounds
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- water
- Prior art date
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- Expired - Lifetime
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- -1 Polyene compounds Chemical class 0.000 title description 26
- 239000000243 solution Substances 0.000 description 39
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 36
- 150000001875 compounds Chemical class 0.000 description 35
- 238000002360 preparation method Methods 0.000 description 34
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 25
- 239000000203 mixture Substances 0.000 description 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 16
- 239000002537 cosmetic Substances 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000004040 coloring Methods 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 15
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 14
- 239000000049 pigment Substances 0.000 description 14
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 238000000034 method Methods 0.000 description 11
- LHRXTFDXJQAGAV-UHFFFAOYSA-L disodium 3-hydroxy-4-(naphthalen-1-yldiazenyl)naphthalene-2,7-disulfonate Chemical compound [Na+].[Na+].Oc1c(cc2cc(ccc2c1N=Nc1cccc2ccccc12)S([O-])(=O)=O)S([O-])(=O)=O LHRXTFDXJQAGAV-UHFFFAOYSA-L 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 7
- 229910052938 sodium sulfate Inorganic materials 0.000 description 7
- 235000011152 sodium sulphate Nutrition 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- 108010010803 Gelatin Proteins 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
- 238000009835 boiling Methods 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 6
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- 239000003086 colorant Substances 0.000 description 6
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- 229920000159 gelatin Polymers 0.000 description 6
- 235000019322 gelatine Nutrition 0.000 description 6
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- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 5
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- BNDRWEVUODOUDW-UHFFFAOYSA-N 3-Hydroxy-3-methylbutan-2-one Chemical compound CC(=O)C(C)(C)O BNDRWEVUODOUDW-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 4
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- 239000003995 emulsifying agent Substances 0.000 description 3
- 150000002170 ethers Chemical class 0.000 description 3
- 238000005984 hydrogenation reaction Methods 0.000 description 3
- 239000005457 ice water Substances 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
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- 238000001953 recrystallisation Methods 0.000 description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
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- 235000013618 yogurt Nutrition 0.000 description 3
- WIDVGAUYQJKBRR-UHFFFAOYSA-N 3-methoxy-3-methyl-2-butanone Chemical compound COC(C)(C)C(C)=O WIDVGAUYQJKBRR-UHFFFAOYSA-N 0.000 description 2
- BDPQEKOXSJWJHX-UHFFFAOYSA-N 8-hydroxy-2,6-dimethylocta-2,4,6-trienal Chemical compound OCC=C(C)C=CC=C(C)C=O BDPQEKOXSJWJHX-UHFFFAOYSA-N 0.000 description 2
- 235000019489 Almond oil Nutrition 0.000 description 2
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 2
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- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- SZKKRCSOSQAJDE-UHFFFAOYSA-N Schradan Chemical group CN(C)P(=O)(N(C)C)OP(=O)(N(C)C)N(C)C SZKKRCSOSQAJDE-UHFFFAOYSA-N 0.000 description 2
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- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
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- VCJMYUPGQJHHFU-UHFFFAOYSA-N iron(3+);trinitrate Chemical compound [Fe+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O VCJMYUPGQJHHFU-UHFFFAOYSA-N 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- AFRJJFRNGGLMDW-UHFFFAOYSA-N lithium amide Chemical compound [Li+].[NH2-] AFRJJFRNGGLMDW-UHFFFAOYSA-N 0.000 description 2
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
- CMSYDJVRTHCWFP-UHFFFAOYSA-N triphenylphosphane;hydrobromide Chemical compound Br.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 CMSYDJVRTHCWFP-UHFFFAOYSA-N 0.000 description 2
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- QMMJWQMCMRUYTG-UHFFFAOYSA-N 1,2,4,5-tetrachloro-3-(trifluoromethyl)benzene Chemical compound FC(F)(F)C1=C(Cl)C(Cl)=CC(Cl)=C1Cl QMMJWQMCMRUYTG-UHFFFAOYSA-N 0.000 description 1
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- 239000011521 glass Substances 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 150000002440 hydroxy compounds Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- IPNPIHIZVLFAFP-UHFFFAOYSA-N phosphorus tribromide Chemical compound BrP(Br)Br IPNPIHIZVLFAFP-UHFFFAOYSA-N 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 239000012485 toluene extract Substances 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 229940086542 triethylamine Drugs 0.000 description 1
- PYOKUURKVVELLB-UHFFFAOYSA-N trimethyl orthoformate Chemical compound COC(OC)OC PYOKUURKVVELLB-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
- A23L5/47—Addition of dyes or pigments, e.g. in combination with optical brighteners using synthetic organic dyes or pigments not covered by groups A23L5/43 - A23L5/46
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4883—Capsule finishing, e.g. dyeing, aromatising, polishing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
- C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
- C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5442—Aromatic phosphonium compounds (P-C aromatic linkage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- This invention relates to coloring agents and the use of these coloring agents in coloring materials such as foodstuffs, pharmaceuticals and cosmetics. This invention also relates to a method of producing these coloring agents including intermediates in the preparation thereof.
- B-carotene and the apocarotenals derived from natural pigments have been found to be particularly useful.
- various disadvantages impose a limit on the general use of these pigments. This is seen by the fact that the color tones achieved with these pigments lie within a relatively narrow range which extends from yellow-orange to yellow-red. Intermediate tones, can of course, be obtained by mixing various components.
- such mixtures of pigments are not color-constant when, as is frequently the case, the indi vidual components are unstable or dilferentially stable.
- These pigments also vary their color with increasing dilution. In the case of carotene, for example, an undesirable color-shift to a pale yellow is observed with decreasing concentration.
- the desired saturated tints may often only be achieved by high concentrations, which are associated with 'high costs and are therefore uneconomical.
- lower alkyl The substituents in the formula shown above which are designated as lower alkyl are lower alkyl residues having from 1 to 4 carbon atoms such as methyl, ethyl, isopropyl.
- the polyene compounds of the Formula I above including the partially hydrogenated products, posses a Bordeaux-red to violet color. They accordingly enrich the small palette of the physiologically inoffensive foodstuff-pigments.
- the compounds are stable in known use forms and they are distinguished from other materials with related color properties in that the tint is not influenced by the concentration. Surprisingly, the solutions of these substances retain their color character unaltered even in strong dilution.
- the compounds of Formula I are accordingly suitable in an outstanding manner for coloring foodstulfs, pharmaceutical and cosmetic preparations.
- the coloring agents of Formula I above can be use to color any conventional foodstuff including beverages, fruits, vegetable preserves, mairnalades, cream foods, confectionery, edible fats, cheese, fish products, pasta, soup powders, etc.
- Any conventional pharmaceutical preparation can !be colored by compounds of Formula 1.
- the typical pharmaceutical preparations which can be colored in accordance with this invention are included drage, suppositories, gelatin capsules and syrups.
- any conventional cosmetic preparation can be colored with the compounds of Formula I above.
- toothpaste, skin creams, lipsticks and nonalcoholic mouthwashes are included.
- the compounds of Formula I above should be added to the material in an amount sufficient to impart a color to the material.
- the foodstuff, pharmaceutical and cosmetic preparation contain from about 0.0000001 part by weight to about 0.1 part by weight of compound of Formula I above based on the weight of the foodstuff, pharmaceutical and cosmetic preparation. It is suitable to make the amount of compounds of Formula I to be added dependent on the nature of the preparations to be colored.
- about 0.000002 part by weight to about 0.000005 part by weight are used for coloring beverages, such as carbonated beverages, about 0.00001 part by weight to about 0.000025 part by weight are used for coloring ice creams, confectionary etc. and 0.00001 part by weight to about 0.00005 part by weight are used for coloring yogurts).
- about 0.0000001 part by Weight to about 0.05 part by Weight of compound of Formula I are used based on the weight of the cosmetic preparation (e.g. from about 0.001 part by weight to about 0.05 part by weight are used for coloring lipsticks and from about 0.0000001 part by weight to about 0.00002 part by weight are used for coloring creams, such as skin creams, toothpaste etc.).
- compositions such as suppositories and syrups preferably contain from about 0.000005 part by weight to about 0.001 part by weight based on the weight of the preparation.
- the coating suitably contains from about 0.001 mg. to about 0.1 mg. of compound of Formula I per cm. surface of the drages.
- the polyene compounds of Formula I can be employed for coloring foodstuffs, pharmaceutical and cosmetic preparations both in the original crystalline form and in a particular water-soluble form.
- the polyene compounds of Formula I above can chiefly be used in the crystalline form for coloring fats and oils, as well as fat-containing substances such as, for example, marzipan, suppositories, lipsticks.
- the polyene compounds of Formula I above can, for example, be dissolved in oils without further ado.
- hard or soft fats Prior to the addition of the pigment, hard or soft fats are conveniently liquified by heating.
- Brusha-ble fats may also be colored by kneading-in an oily pigment-solution.
- Marzipan which, for example, is thoroughly kneaded with a solution of the polyene compound of Formula I in an almond oil, can also be colored in the same way.
- Colored suppositories and lipsticks can, for example, be manufactured in such a way that the polyene compound used as the pigment is stirred into the liquified carrier mass prior to filling into the molds.
- a water-dispersible form of the polyene compounds of Formula I For coloring fat-poor or fatless substances, there is generally used a water-dispersible form of the polyene compounds of Formula I.
- the preparation of these compounds in water dispersible form can be carried out by any of the techniques disclosed in U.S. Pat. 2,861,891, Bauernfeind et al. and U.S. Pat. 3,110,598, Muller et al. These include dissolving the polyene compounds of Formula I in a suitable solvent, homogenizing the solution (together with a stabilizer and a solubilizing or emulsifying agent if required, as well as with an animal or vegetable fat if desired) with Water in the presence of a protecting colloid and evaporating the emulsion formed to dryness under reduced pressure.
- Any conventional organic solvent capable of dissolving the compound of Formula I above can be utilized.
- These solvents include volatile halogenated hydrocarbons such as, for example, chloroform, carbon tetrachlo id met y 4 ene chloride, etc.
- Any conventional antioxidatively active stabilizers can be utilized. These antioxidants include tocopherols, 2,6-ditert-butyl-4-hydroxytoluene [BHT], butylhydroxyanisole [BHA].
- the salts of fatty acid esters of ascorbic acid have been found to be active as solubilizing agents. Any of the conventional solubilizing agents can be utilized in accordance with this invention. Concerning emulsifying agents, any conventional emulsifying agent can be utilized in accordance with this invention.
- the polyoxyethylene derivatives of sorbitan anhydrides partially esterified with fatty acids [Tweens] or non-ionogenic derivatives of fatty compounds with polyoxyethylene derivatives [Cremophores] are, for example, usable.
- the protecting colloids in which the compounds of Formula I are emulsified or dispersed include any of the conventional water soluble gelable colloids.
- the color brilliance of the aqueous solutions can be increased by the addition of any animal fat (e.g., beef tallow) or vegetable oil (e.g., groundnut oil).
- the linkage or condensation of the compounds of Formula II above, and II above, to produce a compound in accordance with Formula I above is carried out in an inert solvent in the presence of an alkali condensation agent.
- temperature and pressure are not critical and the reactions can be carried out at room temperature and atmospheric pressure or at elevated, temperatures and reduced pressure. If quicker reaction times are desired, it is preferred to utilize elevated temperatures such as between 40 and C.
- elevated temperatures such as between 40 and C.
- 1 mole of a compound of Formula II above is condensed with 2 moles of a compound of Formula III above.
- a molar excess of the compound of Formula III above can be utilized, that is, i.e., from about 2 moles to about 4 moles of the compound of Formula III per mole of the compound of Formula II. Generally, more than 4 moles of the compound of Formula III per mole of the compound of Formula II above are seldom utilized since no additional beneficial results are achieved thereby.
- Any conventional inert solvent can be utilized in carrying out the condensation reaction of compounds of Formulas II and III.
- Typical solvents which can be utilized in accordance with this invention include benzene, toluene, xylene, dimethylformamide, methylene chloride, dichloro-ethylene, etc.
- Any conventional organic or inorganic alkali can be utilized as the condensation agent in accordance with this invention.
- the condensation of the compounds of Formula II above, with compounds of the Formula III above, produce a compound of Formula I Where A is --CEC--.
- the compounds of Formula I above where A is CEC- can be catalytically hydrogenated in an inert solvent such as ethyl acetate, toluene or petroleum ether in the presence of a selective hydrogenation catalyst, e.g., a palladium-lead catalyst in the presence of quinoline, of the type disclosed in the publication Helv. Chim. Acta, 35, 446 (1952).
- the compound of Formula II can be partially hydrogenated in the above manner prior to reaction with compounds of Formula III to reduce the single bond therein to a double bond.
- the 2,6,10,15,l9,23 hexamethyl-tetracosa-2,4,6,8,l0, 14,16,18,20,22-decaen-l2-yne-1,2,4 dial of Formula 11 above, which is employed as a starting compound in the processes of this invention, can be manufactured by chain lengthening a suitable lower membered dialdehyde. This chain lengthening is carried out by condensing 1 mole of 2,7-dimethyl-octa-2,-6-dien-4-yne-1,8-dial with 2 moles of acetalized 3,7 dimethyl 8-oxo-octa-2,4,6-trienylphosphonium bromide.
- the condensation compounds of Formulas II and III above which are preferred are 3- methyl-3-hydroxy-2-butanone and 3-methyl 3 methoxy- 2-butanone.
- ammonia-alkaline lithium amide solution can be manufactured as follows:
- 0.5 g. of finely divided lithium are introduced with stirring into 600 ml. of liquid ammonia. After the addition of 0.5 g. of iron (III) nitrate, compressed air is led into the solution for a few seconds. As soon as the blue color of the solution has disappeared, a further 7.1 g. of finely divided lithium are added. The evaporating ammonia is condensed in a condenser charged with acetone/ Dry Ice and led back to the reaction mixture. The mixture is stirred until the blue color disappears [15 to 60 minutes].
- reaction solution is stirred for 90 minutes, then treated with 170 ml. of dry toluene and immediately subsequently with 114 g. of 3-ethoxy-2- methylacrolein in a rapid stream and further stirred for 30 minutes.
- the mixture is subsequently neutralized by the addition of 80 ml. of glacial acetic in 200 ml. of toluene.
- the acid solution is conveniently added through a dropping funnel of which the exit tube dips into the reaction mixture.
- the ammonia is evaporated off, with stirring, until the temperature in the reaction vessel has risen to 40 C.
- the toluene is subsequently distilled off under reduced pressure.
- the residual 1-ethoxy-8-(1-rnethoxy 1 methylethoxy) 2,6 dimethyl octa 2,6- dien-4-yn-3-ol is a light-brown oil.
- the 5-(l-methoxy-methylethoxy)-3 methyl pent 3- en-l-yne employed as starting compound can be manufactured as follows: 96 g. of 3-methyl-pent-2-en-4-yn-1-ol are, after the addition of 0.5 ml. of percent methyl alcoholic p-toluenesulphonic acid, treated with stirring and cooling at 5 to C. with 79 g. of isopropenyl methyl ether. The acetal is not isolated, but further processed directly.
- the ether extract is washed twice with icewater, three times with ice-cold 10 percent potassium hydrogen carbonate solution and twice with ice-water, briefly dried over sodium sulphate and immediately evaporated under reduced pressure at 20 C.
- the residual 8- bromo-2,6-dimethyl-octa-2,4,6-trien-1-al crystallizes after trituration with a little ether, M.P. 6870 C.; absorption maximum (in petroleum ether) 311 mg.
- the unstable compound is immediately dissolved in 50 ml. of methylene chloride and treated with 26 g. of triphenyl-phosphine. In doing so, the solution warms up to boiling. After 1 to 1% hours, 200 ml.
- E:Zem. 225, 40s, 2450, 1910.
- dialdehyde employed as starting compound can be manufactured as follows:
- the catalyst is filtered off.
- the filtrate is successively washed with N sulphuric acid, with water, with an aqueous sodium hydrogen carbonate solution and again with water, dried over sodium sulphate, filtered and evaporated under reduced pressure.
- the residue is dissolved in 500 ml. of acetic acid ethyl ester and, after the addition of 200 mg. of iodine, heated to boiling under lighting with a 500 watt lamp for 3 hours.
- EXAMPLE 4 According to the same mode of working described in Example 2, there can be manufactured: from at least 2 moles of 3-methyl-3-hydroxy-2-butanone and 1 mole of 2,6,10,15,19,23 hexamethyl-tetracosa 2,4,6,8,10,14,16, 18,20,22 decaen-12-yne-1,24-dial, 2,6,10,14,19,23,27,31- octamethyl-2,31-dihydroxy dotriaconta 4,6,8,10,12,14, 18,20,22,24,26,28 dodecaen-l6-yne-3,30'-dione M.P. 245- 247 C.; U.V. absorption maximum (in chloroform) 513 l;
- polyene compounds of Formula I for coloring foodstuffs, pharmaceutical and cosmetic preparations in accordance with the invention can, using a representative member of this class of compounds, be elucidated by the following examples.
- EXAMPLE 5 Manufacture of Bordeaux-red colored drages 10,000 dragee kernels each of 150 mg. are covered white with sugar syrup, starch and talc up to a kernel weight of 190 mg.
- 30 g. of color-preparation containing 300 mg. of 2,6,10, 14,19,23,27,31 octamethyl 2,3 l-dimethoxy-dotriaconta- 4,6,8,10,12,14,16,18,20,22,24,26,28 tridecaen-3,30-dione are soaked with 30 g. of water, combined with a solution from 330 g. of sugar and 135 g. of water which has been heated to boiling and subsequently cooled to 6070 C.
- the violet-colored sugar solution is applied little by little to the white-coated drages situated in the rotating coating-kettle, sprayed with cold air.
- the dragees are polished in the usual manner.
- the color layer of a dragee (weight 220 mg. diameter 1 cm., thickness 3 mm.) contains 0.03 mg. of the pure pigment named above.
- the water-soluble preparation employed as color-dispenser can, for example, be manufactured as follows:
- 1 g. of a polyene compound of Formula I is dissolved in 100 ml. of chloroform and, together with 100 mg. of tocopherol, 2 g. of arachis oil and 2 g. of ascorbyl palmitate, introduced into a solution of 60 g. of gelatin, 35 g. of sugar and 0.5 g. of calcined soda in 250 ml. of water and homogenized.
- the colored chloroform-containing gelatin emulsion is poured on a metal sheet and subsequently dried in vacuum. The dry product is broken into small pieces.
- EXAMPLE 6 Manufacture of violet-colored sweets 1 g. of purchasable fondant-composition is homogeneously mixed with a solution of 1.5 g. of color-preparation containing 15 mg. of 2,6,10,14,19,23,27,3l-octamethyl-2,31 dimethoxy-dotriaconta-4,6,8,10,12,14,16,18,20,22-
- EXAMPLE 8 Manufacture of Bordeaux-red caramels 1.5 g. of color-preparation containing 15 mg. of 2,6,10, 14,19,23,27,3l octamethyl-2,3l-dimethoxy-dotriaconta- 4,6,8,'10,12,14,16,18,20,22,24,26,28 tridecaen 330-dione [manufactured analogously to Example 5] are dissolved in 5 ml. of water and added towards the end of the cooking process or during the subsequent processing of 1 kg. of bon-bon composition and homogeneously worked in.
- EXAMPLE 9 Manufacture of carbonic acid-containing cassis-colored refreshing drinks 4 g. of color-preparation containing 40 mg. of 2,6,10, 14,19,23,27,31 octamethyl-2,3 l-dimethoxy-dotriaconta- 4,6,8,10,12,l4,16,18,20,22,24,28 tridecaen 3,30 dione [manufactured analogously to Example 5] are dissolved in 20 ml. of warm water and homogenized with g. of sugar syrup. After the addition of citric acid and aroma tmaterails, the colored solution is diluted to 10 liters with carbonic acid-containing water and filled into botles having stirrup-closures.
- EXAMPLE 10 Manufacture of violet-brownish colored suppositories 100 g. of suppository composition are heated with 100 mg. of crystallized 2,6,10,14,19,23,27,31-octamethyl-2,31- dimethoxy-dotriaconta 4,6,25,10,12,14,l6,18,20,22,24,26,
- 28-tridecaen-3,30-dione up to complete solution of the pigment.
- u-Tocopherol, BHT, BHA, gallates etc. can be admixed as antioxidants.
- the violet fatty composition is poured into the usual molds and allowed to cool.
- EXAMPLE 11 Manufacture of violet-colored gelatin capsules Manufacture of raspberry-red syrups and confectionery Per kg. of syrup or confectionery, 2 g. of color-preparation containing 20 mg. of 2,6,10,14,19,23,27,3l-octamethyl 2,3l-dimethoxy-dotriaconta-4,6,8,l0,12,l4,16,- 18,20,22,24,26,28 tridecaen 3,30-dione [manufactured analogously to Example 5] are dissolved warm in 5 ml. of Water and added to the syrup or confectionary composition towards the end of the thickening process.
- EXAMPLE 14 Manufacture of a weekly violet-colored daytime cream 1 g. of color-preparation containing mg. of 2,6,10,- 14,19,23,27,31 octamethyl-2,31dimethoxy-dotriaconta- 4,6,8,l0,l2,l4,l6,l8,20,22,24,26,28 tridccaen 3,30 dione [manufactured analogously to Example 5] is dissolved in 65 ml. of warm water. The solution is emulsified in a salve base which consists of 15 g. of cetyl alcohol and octadecyl alcohol 3 g. of spermaceti, 1 g. of butyl stearate, 1 g. of lanolin, 5 g. of Cetiol, 2.8 g. of Carol, 8 g. of glycerin or propyleneglycol and 0.5 g. of perfume oil composition.
- a salve base which consists of
- EXAMPLE 15 Manufacture of a raspberry-colored pudding composition 2 g. of color-preparation containing mg. of 2,6,10,- 14,19,23,27,31 octamethyl-2,3 l-dimethoxy-dotriaconta- 10 4,6,8,10,12,14,16,l8,20,22,24,26,28 tridecaen-3,30-dione [manufactured analogously to Example 5] are admixed with the pudding powder sufiicient for 1 liter of completely prepared pudding and [the mixture] further processed as usual by stirring or boiling up with milk.
- EXAMPLE 16 Manufacture of Bordeaux-red colored yogurt 2 g. of color-preparation containing 20 mg. of 2,6,10,- 14,19,23,27,31 octarnethyl-2,3l-dimethoxy-dotriaconta- 4,6,8,10,12,14,l6,18,20,22,24,26,28 tridecaen-3,30-dione [manufactured analogously to Example 5] are dissolved warm in 5 ml. of water, mixed with 1 liter of milk and [the mixture] processed in the usual manner to [give] yogurt.
- EXAMPLE 17 Manufacture of a Bordeaux-red marzipan composition 10 mg. of crystalline 2,6,l0,14,19,23,27,3l-octamethyl- 2,31 dimethoxy-dotriaconta-4,6,8,10,12,14,16,18,20,22,- 24,26,28-tridecaen-3,30-dioue are dissolved hot in 10 g. of almond oil, and, while still warm, worked into 1 kg, of marzipan composition manually or by machine.
- the marzipan composition can, if desired also be colored with a water-soluble pigment preparation which, dissolved in a little water, is admixed with the marzipan composition.
- EXAMPLE 18 Manufacture of a pale Bordeaux-red colored toothpaste 0.5 g. of pigment powder containing 5 mg. of 2,6,10,- l4,l9,23,27,31 octamethyl-2,3l-dimethoxy-dotriaconta 4,6,8,10,12,14,16,18,20,22,24,26,28 tridecaen-3,30-dione [manufactured analogously to Example 5] are dissolved in 2 ml. of water and homogeneously worked into g. of white toothpaste of the usual composition. The same pigment preparation can also be added, if desired, to the raw materials which are dissolved in water or converted into a paste with water.
- R is selected from the group consisting of hydrogen and a lower alkyl group.
- Raphael Adv. in Org. Chem, vol. 4, pp. 186 and 190- 192 (1963).
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Description
United States Patent 6 Int. Cl. c07c 49/04, 49/20 U.S. Cl. 260-593 3 Claims ABSTRACT OF THE DISCLOSURE Ethers of polyene diketo compounds which are useful as coloring agents for foodstulfs, pharmaceutical preparations and cosmetic preparations and a method for preparing these diketo ether compounds. The method of preparing these diketo ether compounds is carried out by condens a C dialdehyde with a monoketone ether.
BACKGROUND OF THE INVENTION This invention relates to coloring agents and the use of these coloring agents in coloring materials such as foodstuffs, pharmaceuticals and cosmetics. This invention also relates to a method of producing these coloring agents including intermediates in the preparation thereof.
Of the pigments of natural or synthetic origin which are suitable for coloring foodstufis, B-carotene and the apocarotenals derived from natural pigments have been found to be particularly useful. However, various disadvantages impose a limit on the general use of these pigments. This is seen by the fact that the color tones achieved with these pigments lie within a relatively narrow range which extends from yellow-orange to yellow-red. Intermediate tones, can of course, be obtained by mixing various components. However, such mixtures of pigments are not color-constant when, as is frequently the case, the indi vidual components are unstable or dilferentially stable. These pigments also vary their color with increasing dilution. In the case of carotene, for example, an undesirable color-shift to a pale yellow is observed with decreasing concentration. The desired saturated tints may often only be achieved by high concentrations, which are associated with 'high costs and are therefore uneconomical.
SUMMARY OF THE INVENTION The present invention is concerned with polyene compounds of the general formula:
OR W m o- A /K in which R representas hydrogen or a lower alkyl group and A is either -CE or CH=CH-, and process for their production which are utilized as coloring agents for foodstuffs, pharmaceutical and cosmetic preparations.
The substituents in the formula shown above which are designated as lower alkyl are lower alkyl residues having from 1 to 4 carbon atoms such as methyl, ethyl, isopropyl.
The process in accordance with the invention where the polyene dialdehyde compounds of the Formula I above was prepared, is carried out by reacting a dialdehyde of the formula:
0 MMA/s/ XAW' 0 with at least 2 moles of a compound of the general formula:
0B (ill) in which R has the significance given above, with the help of an alkaline condensation agent in the presence of an inert solvent and, if desired, the product obtained partially hydrogenated at the triple bond and isomerized.
Of the products of Formula I and the polyene compounds manufacturable therefrom by partial hydrogenation and isomerization, 2,6,10,14,19,23,27,3l-octamethyl- 2,3 l-dimethoxydotriaconta 4,6,8,l0,12,14,18,20,22,24,26, 28-dodecaen-l6-yne-3,30-dione which imparts to foodstuffs, phamaceutical and cosmetic preparations an intensive Bordeaux-red color, as well as 2,6,l0,l4,l9,23,27,3 loctamethyl-2,3-dimethoxydotriaconta 4,6,8,10,12,l4,16, 18,20,22,24,26,28-tridecaen-3,3l-dione which imparts to foodstuffs, pharmaceutical and cosmetic preparations a violet color, are especially valuable.
It has now been found the polyene compounds of the Formula I above, including the partially hydrogenated products, posses a Bordeaux-red to violet color. They accordingly enrich the small palette of the physiologically inoffensive foodstuff-pigments. The compounds are stable in known use forms and they are distinguished from other materials with related color properties in that the tint is not influenced by the concentration. Surprisingly, the solutions of these substances retain their color character unaltered even in strong dilution. The compounds of Formula I are accordingly suitable in an outstanding manner for coloring foodstulfs, pharmaceutical and cosmetic preparations.
DETAILED DESCRIPTION The coloring agents of Formula I above, in accordance with this invention, can be use to color any conventional foodstuff including beverages, fruits, vegetable preserves, mairnalades, cream foods, confectionery, edible fats, cheese, fish products, pasta, soup powders, etc. Any conventional pharmaceutical preparation can !be colored by compounds of Formula 1. Among the typical pharmaceutical preparations which can be colored in accordance with this invention are included drage, suppositories, gelatin capsules and syrups. Also any conventional cosmetic preparation can be colored with the compounds of Formula I above. Among the conventional cosmetic preparations which can be colored in accordance with this invention are included, toothpaste, skin creams, lipsticks and nonalcoholic mouthwashes.
In coloring materials such as foodstuffs, cosmetic and pharmaceutical preparations, the compounds of Formula I above should be added to the material in an amount sufficient to impart a color to the material. Gen- 5 erally, it is preferred that the foodstuff, pharmaceutical and cosmetic preparation contain from about 0.0000001 part by weight to about 0.1 part by weight of compound of Formula I above based on the weight of the foodstuff, pharmaceutical and cosmetic preparation. It is suitable to make the amount of compounds of Formula I to be added dependent on the nature of the preparations to be colored. Thus, for coloring foodstuffs, it is advantageous to add from about 0.0000001 part by weight to about 00001 part by weight of compound of Formula I based on the weight of the preparation (e.g. about 0.000002 part by weight to about 0.000005 part by weight are used for coloring beverages, such as carbonated beverages, about 0.00001 part by weight to about 0.000025 part by weight are used for coloring ice creams, confectionary etc. and 0.00001 part by weight to about 0.00005 part by weight are used for coloring yogurts). In the cosmetic field preferably about 0.0000001 part by Weight to about 0.05 part by Weight of compound of Formula I are used based on the weight of the cosmetic preparation (e.g. from about 0.001 part by weight to about 0.05 part by weight are used for coloring lipsticks and from about 0.0000001 part by weight to about 0.00002 part by weight are used for coloring creams, such as skin creams, toothpaste etc.). Pharmaceutical preparations, such as suppositories and syrups preferably contain from about 0.000005 part by weight to about 0.001 part by weight based on the weight of the preparation. In case of coloring drages, the coating suitably contains from about 0.001 mg. to about 0.1 mg. of compound of Formula I per cm. surface of the drages. Although greater amounts than the parts by weight of the compound of Formula I specified above can be incorportaed into the foodstuff, pharmaceutical or cosmetic preparation, however, .these high amounts are seldom utilized since no additional benefits, as far as color is concerned, is obtained by utilizing such large amounts of the compounds of Formula I above.
The polyene compounds of Formula I can be employed for coloring foodstuffs, pharmaceutical and cosmetic preparations both in the original crystalline form and in a particular water-soluble form.
The polyene compounds of Formula I above can chiefly be used in the crystalline form for coloring fats and oils, as well as fat-containing substances such as, for example, marzipan, suppositories, lipsticks. The polyene compounds of Formula I above, can, for example, be dissolved in oils without further ado. Prior to the addition of the pigment, hard or soft fats are conveniently liquified by heating. Brusha-ble fats may also be colored by kneading-in an oily pigment-solution. Marzipan, which, for example, is thoroughly kneaded with a solution of the polyene compound of Formula I in an almond oil, can also be colored in the same way. Colored suppositories and lipsticks can, for example, be manufactured in such a way that the polyene compound used as the pigment is stirred into the liquified carrier mass prior to filling into the molds.
For coloring fat-poor or fatless substances, there is generally used a water-dispersible form of the polyene compounds of Formula I. The preparation of these compounds in water dispersible form can be carried out by any of the techniques disclosed in U.S. Pat. 2,861,891, Bauernfeind et al. and U.S. Pat. 3,110,598, Muller et al. These include dissolving the polyene compounds of Formula I in a suitable solvent, homogenizing the solution (together with a stabilizer and a solubilizing or emulsifying agent if required, as well as with an animal or vegetable fat if desired) with Water in the presence of a protecting colloid and evaporating the emulsion formed to dryness under reduced pressure.
Any conventional organic solvent capable of dissolving the compound of Formula I above, can be utilized. These solvents include volatile halogenated hydrocarbons such as, for example, chloroform, carbon tetrachlo id met y 4 ene chloride, etc. Any conventional antioxidatively active stabilizers can be utilized. These antioxidants include tocopherols, 2,6-ditert-butyl-4-hydroxytoluene [BHT], butylhydroxyanisole [BHA].
The salts of fatty acid esters of ascorbic acid (e.g., the sodium salt of ascorbyl palmitate), inter alia, have been found to be active as solubilizing agents. Any of the conventional solubilizing agents can be utilized in accordance with this invention. Concerning emulsifying agents, any conventional emulsifying agent can be utilized in accordance with this invention. The polyoxyethylene derivatives of sorbitan anhydrides partially esterified with fatty acids [Tweens] or non-ionogenic derivatives of fatty compounds with polyoxyethylene derivatives [Cremophores] are, for example, usable. The protecting colloids in which the compounds of Formula I are emulsified or dispersed include any of the conventional water soluble gelable colloids. Gelatin, dextrin, pectin, tragacanth, guar (especially in the presence of saccharose, glycerin, sorbitol), have, for example, been found to be useful as protecting colloids. The color brilliance of the aqueous solutions can be increased by the addition of any animal fat (e.g., beef tallow) or vegetable oil (e.g., groundnut oil).
The linkage or condensation of the compounds of Formula II above, and II above, to produce a compound in accordance with Formula I above, is carried out in an inert solvent in the presence of an alkali condensation agent. In carrying out this condensation reaction, temperature and pressure are not critical and the reactions can be carried out at room temperature and atmospheric pressure or at elevated, temperatures and reduced pressure. If quicker reaction times are desired, it is preferred to utilize elevated temperatures such as between 40 and C. Generally in carrying out the condensation reaction, 1 mole of a compound of Formula II above is condensed with 2 moles of a compound of Formula III above. If desired, a molar excess of the compound of Formula III above can be utilized, that is, i.e., from about 2 moles to about 4 moles of the compound of Formula III per mole of the compound of Formula II. Generally, more than 4 moles of the compound of Formula III per mole of the compound of Formula II above are seldom utilized since no additional beneficial results are achieved thereby.
Any conventional inert solvent can be utilized in carrying out the condensation reaction of compounds of Formulas II and III. Typical solvents which can be utilized in accordance with this invention include benzene, toluene, xylene, dimethylformamide, methylene chloride, dichloro-ethylene, etc. Any conventional organic or inorganic alkali can be utilized as the condensation agent in accordance with this invention. Thereby, alkalis under which may be used alkali metal or alkali earth metal hydroxides. Of the alkali metal hydroxides which can be utilized in the process of the conversion of potassium hydroxide or sodium hydroxide are preferred.
The condensation of the compounds of Formula II above, with compounds of the Formula III above, produce a compound of Formula I Where A is --CEC--. This may be reduced to a compound where A is CH=CH- by an conventional partial hydrolyzation technique. For example, the compounds of Formula I above where A is CEC- can be catalytically hydrogenated in an inert solvent such as ethyl acetate, toluene or petroleum ether in the presence of a selective hydrogenation catalyst, e.g., a palladium-lead catalyst in the presence of quinoline, of the type disclosed in the publication Helv. Chim. Acta, 35, 446 (1952). However, if desired, the compound of Formula II can be partially hydrogenated in the above manner prior to reaction with compounds of Formula III to reduce the single bond therein to a double bond.
The 2,6,10,15,l9,23 hexamethyl-tetracosa-2,4,6,8,l0, 14,16,18,20,22-decaen-l2-yne-1,2,4 dial of Formula 11 above, which is employed as a starting compound in the processes of this invention, can be manufactured by chain lengthening a suitable lower membered dialdehyde. This chain lengthening is carried out by condensing 1 mole of 2,7-dimethyl-octa-2,-6-dien-4-yne-1,8-dial with 2 moles of acetalized 3,7 dimethyl 8-oxo-octa-2,4,6-trienylphosphonium bromide. The condensation compounds of Formulas II and III above which are preferred are 3- methyl-3-hydroxy-2-butanone and 3-methyl 3 methoxy- 2-butanone.
The invention is further illustrated by the following examples.
EXAMPLE 1 (A) Preparation of ether 175 g. of crude 5 (1-methoxy-1-methylethoxy)-3- methyl-pent-3-en-1-yne are introduced in a rapid-stream into a solution of lithium amide in liquid ammonia.
The ammonia-alkaline lithium amide solution can be manufactured as follows:
0.5 g. of finely divided lithium are introduced with stirring into 600 ml. of liquid ammonia. After the addition of 0.5 g. of iron (III) nitrate, compressed air is led into the solution for a few seconds. As soon as the blue color of the solution has disappeared, a further 7.1 g. of finely divided lithium are added. The evaporating ammonia is condensed in a condenser charged with acetone/ Dry Ice and led back to the reaction mixture. The mixture is stirred until the blue color disappears [15 to 60 minutes].
The dark clear reaction solution is stirred for 90 minutes, then treated with 170 ml. of dry toluene and immediately subsequently with 114 g. of 3-ethoxy-2- methylacrolein in a rapid stream and further stirred for 30 minutes. The mixture is subsequently neutralized by the addition of 80 ml. of glacial acetic in 200 ml. of toluene. The acid solution is conveniently added through a dropping funnel of which the exit tube dips into the reaction mixture. The ammonia is evaporated off, with stirring, until the temperature in the reaction vessel has risen to 40 C. The toluene is subsequently distilled off under reduced pressure. The residual 1-ethoxy-8-(1-rnethoxy 1 methylethoxy) 2,6 dimethyl octa 2,6- dien-4-yn-3-ol is a light-brown oil. U.V. maximum [in ethanol]; 228 mu; e=18000; n =1.5120; d.=l.002.
The 5-(l-methoxy-methylethoxy)-3 methyl pent 3- en-l-yne employed as starting compound can be manufactured as follows: 96 g. of 3-methyl-pent-2-en-4-yn-1-ol are, after the addition of 0.5 ml. of percent methyl alcoholic p-toluenesulphonic acid, treated with stirring and cooling at 5 to C. with 79 g. of isopropenyl methyl ether. The acetal is not isolated, but further processed directly.
(B) Preparation of hydroxy compound 270 g. of l-ethoxy-8-(l-methoxy-l-methylethoxy)-2,6- dimethyl-octa-2,6-dien-4-yn-3-o1 are dissolved in 400 ml. of toluene and, with cooling and strong stirring, treated with 50 ml. of 2 percent sulphuric acid and 50 ml. of methanol, in doing which the temperature should not exceed 25 C. The reaction mixture is subsequently stirred at to C. with nitrogen gassing for 2 hours. The toluene phase is separated, washed with 400 ml. of a 10 percent aqueous sodium sulphate solution and subsequently with 400 ml. of a 5 percent sodium hydrogen carbonate solution. The aqueous phases are separated and one more shaken outwith 100 ml. of toluene. The combined toluene extracts are concentrated at 50 C. to a volume of 400 ml. The 2,6-dimethyl-8-hydroxy-octa-2,6-dien-4-yn-1-al dissolved in toluene can be acylated without isolation as described hereinafter. The toluene solution can also be completely evaporated and the residue crystallized from dibutyl ether. The 2,6-dimethyl-S-hydroxy-octa-Z,6-dien- 4-yn-1-al thus obtained melts at 32-34 C.
(C) Hydrogenation of ester 5.0 g. of 2,6-dimethyl-8-hydroxy-octa-2,6-dien-4-yn-1-a1 are dissolved in 30 ml. of toluene and, after the addition of 0.4 g. of a palladium/calcium carbonate catalyst deactivated by addition of lead and quinoline [Helv. Chim. Acta, 35 (1952), 446], hydrogenated up to the uptake of 1.05 equivalents of hydrogen. The reaction solution, after separation of the catalyst, is successively washed with 0.5 N sulphuric acid, potassium hydrogen carbonate solution and water, then dried over sodium sulphate and treated with a solution of 0.02 g. of iodine in 2 ml. of toluene. The solution is allowed to stand at room temperature for 18 hours and is subsequently successively washed with a 5 percent sodium thiosulphate solution and water, then dried over sodium sulphate and evaporated under reduced pressure. The residual 2,6-dimethyl8-hydroxyocta-2,4,6-trien-1-al melts at 70 to 72 C. after recrystallization from ethyl ether/petroleum ether [boiling range 30 to 40 C.].
(D) Preparation of 3,7-dimethy1-8-oxo-octa-2,4,6- trienyl triphenyl phosphonium bromide A mixture of 10.5 ml. of dimethylformamide and 45 ml. of methylene chloride is treated with stirring at -20 C. with 6.5 ml. of phosphorous tribromide and thereupon within 20 minutes with a solution of 16.6 g. of 8-hydroxy- 2,6-dimethyl-octa-2,4,6-trien-1-al in 25 ml. of methylene chloride. The reaction mixture is stirred at --10 C. for 1 hour, then poured in ice-water and extracted with 300 ml. of ether. The ether extract is washed twice with icewater, three times with ice-cold 10 percent potassium hydrogen carbonate solution and twice with ice-water, briefly dried over sodium sulphate and immediately evaporated under reduced pressure at 20 C. The residual 8- bromo-2,6-dimethyl-octa-2,4,6-trien-1-al crystallizes after trituration with a little ether, M.P. 6870 C.; absorption maximum (in petroleum ether) 311 mg. Without further purification, the unstable compound is immediately dissolved in 50 ml. of methylene chloride and treated with 26 g. of triphenyl-phosphine. In doing so, the solution warms up to boiling. After 1 to 1% hours, 200 ml. of acetic acid ethyl ester are slowly added while scratching with a glass rod. The 3,7-dimethyl-8-oxo-octa-2,4,6- trienyl triphenyl phosphonium bromide crystallizing out is filtered oil in the cold after standing for 12 hours. M.P. 203-205 C.; absorption maximum (in ethanol) 315 m EXAMPLE 2 44 g. of 3-methyl-3-methoxy-2-butanone are introduced into a solution of 10 g. of 2,6,10,15,19,23-hexamethyltetracosa 2,4,6,8,10,14,16,'18,20,22 decaen-12-yne-l,24- dial in 500 ml. of methylene chloride and treated dropwise within 2 hours with a solution of 5 g. of potassium hydroxide in 50 m1. of methanol. The reaction mixture is subsequently heated to 50 C. in a nitrogen atmosphere, stirred for 24 hours, then cooled and poured into ice-cold N sulphuric acid. The methylene chloride phase which separates is successively washed with water, with an aqueous sodium hydrogen carbonate solution and again with water, dried over sodium sulphate and evaporated under reduced pressure. The violet 2,6,10,14,19,23,27,31- octamethyl-2,3 l-dimethoxy dotriaconta 4,6,8,l0,12,14, 18,20,22,24,'26,28-dodecaen 16 yne 330 dione which remains behind melts at 2l7-219 C. after recrystallization twice from methylene chloride/ ethanol; U.V. maxima (in chloroform) 304, 355, 509, 536 (shoulder) ma;
E:Zem.=225, 40s, 2450, 1910.
The dialdehyde employed as starting compound can be manufactured as follows:
g. of 3,7-dimethyl-8-oxo-octa-2,4,6'trienyl triphenyl phosphonium bromide, prepared in Example 1, in ml. of abs. methanol are treated with 20 ml. of orthoformic acid trimethyl ester and a solution of 0.1 g. of
p-toluenesulphonic acid and 0.1 ml. of 85% phosphoric acid in 20 ml. of abs. methanol and allowed to stand at room temperature for 18 hours. The acetal formed which is present in solution is treated with stirring with ml. of pyridine and immediately thereafter simultaneously with a solution of 8 g. of sodium in 200 ml. of abs. methanol and a solution of 16.2 g. of 2,7-dimethyl-octa-2,6-dien- 4-yne-1,8-dial in 200 ml. of benzene. The reaction mixture is heated to 50 C. for 4 hours, then diluted with water and extracted with methylene chloride. The methylene chloride extract is washed neutral, dried over sodium sulphate and evaporated. The crude 2,6,10,15,19,23-hexamethyl tetracosa 2,4,6,8,10,14,16,18,20,22 decaen-lZ- yne-1,24-dial tetramethyl acetal which remains behind is dissolved in 400 ml. of acetone and after the addition of 50 ml. of N sulphuric acid, heated to boiling for 45 minutes. The dialdehyde which precipitates in violet crystals on cooling melts at 227-229 C. after recrystallization from methylene chloride/ethanol; U.V. absorption maxima (in chloroform) 274, 325, 485, 517 m EXAMPLE 3 10.3 g. 2,6,10,14,19,23,27,31 octamethyl 2,31 dimethoxydotriaconta 4,6,8,10,12,14,1=8,20,22,24,26,28- dodecaen-l6-yne-3,30-dione are dissolved in 500 ml. of methylene chloride and, after the addition of 5 g. of palladium/calcium carbonate catalyst partially poisoned by leadand quinoline-addition, 0.5 ml. of quinoline and 2 ml. of triethyl amine, hydrogenated until no more hydrogen is taken up. The catalyst is filtered off. The filtrate is successively washed with N sulphuric acid, with water, with an aqueous sodium hydrogen carbonate solution and again with water, dried over sodium sulphate, filtered and evaporated under reduced pressure. The residue is dissolved in 500 ml. of acetic acid ethyl ester and, after the addition of 200 mg. of iodine, heated to boiling under lighting with a 500 watt lamp for 3 hours. The 2,6,10,14, 19,23,27,31-octamethyl 2,31 dimethoxy-dotriaconta- 4,6,8,10,12,l4,16,18,20,22,24,26,28-tridecaen 3,30 dione which precipitates in violet crystals after concentration of the solution to 150 ml. melts at 223224 C.; U.V. absorption maxima (in carbon disulphide) 556 and 594 mu;
EiT, ,=2065 and 1590.
EXAMPLE 4 According to the same mode of working described in Example 2, there can be manufactured: from at least 2 moles of 3-methyl-3-hydroxy-2-butanone and 1 mole of 2,6,10,15,19,23 hexamethyl-tetracosa 2,4,6,8,10,14,16, 18,20,22 decaen-12-yne-1,24-dial, 2,6,10,14,19,23,27,31- octamethyl-2,31-dihydroxy dotriaconta 4,6,8,10,12,14, 18,20,22,24,26,28 dodecaen-l6-yne-3,30'-dione M.P. 245- 247 C.; U.V. absorption maximum (in chloroform) 513 l;
The use of polyene compounds of Formula I for coloring foodstuffs, pharmaceutical and cosmetic preparations in accordance with the invention can, using a representative member of this class of compounds, be elucidated by the following examples.
EXAMPLE 5 Manufacture of Bordeaux-red colored drages 10,000 dragee kernels each of 150 mg. are covered white with sugar syrup, starch and talc up to a kernel weight of 190 mg.
30 g. of color-preparation containing 300 mg. of 2,6,10, 14,19,23,27,31 octamethyl 2,3 l-dimethoxy-dotriaconta- 4,6,8,10,12,14,16,18,20,22,24,26,28 tridecaen-3,30-dione are soaked with 30 g. of water, combined with a solution from 330 g. of sugar and 135 g. of water which has been heated to boiling and subsequently cooled to 6070 C.
and homogenized. The violet-colored sugar solution is applied little by little to the white-coated drages situated in the rotating coating-kettle, sprayed with cold air. The dragees are polished in the usual manner. The color layer of a dragee (weight 220 mg. diameter 1 cm., thickness 3 mm.) contains 0.03 mg. of the pure pigment named above.
The water-soluble preparation employed as color-dispenser can, for example, be manufactured as follows:
1 g. of a polyene compound of Formula I is dissolved in 100 ml. of chloroform and, together with 100 mg. of tocopherol, 2 g. of arachis oil and 2 g. of ascorbyl palmitate, introduced into a solution of 60 g. of gelatin, 35 g. of sugar and 0.5 g. of calcined soda in 250 ml. of water and homogenized. The colored chloroform-containing gelatin emulsion is poured on a metal sheet and subsequently dried in vacuum. The dry product is broken into small pieces.
EXAMPLE 6 Manufacture of violet-colored sweets 1 g. of purchasable fondant-composition is homogeneously mixed with a solution of 1.5 g. of color-preparation containing 15 mg. of 2,6,10,14,19,23,27,3l-octamethyl-2,31 dimethoxy-dotriaconta-4,6,8,10,12,14,16,18,20,22-
Manufacture of pale violet colored ice cream 2 g. of color preparation containing 20 mg. of 2,6,10, 14,19,23,27,31 octamethyl-2,3 l-dimethoxy-dotriaconta- 4,6,8,10,12,14,16,18,20,22,24,26,28 -tridecaen 3,30-dione [manufactured analogously to Example 5] are dissolved warm in 5 ml. of water and added to the raw materials such as cream, milk, sugar, gelatin, aroma material necessary for 1 liter of ice cream. There is obtained a pale violet ice cream.
EXAMPLE 8 Manufacture of Bordeaux-red caramels 1.5 g. of color-preparation containing 15 mg. of 2,6,10, 14,19,23,27,3l octamethyl-2,3l-dimethoxy-dotriaconta- 4,6,8,'10,12,14,16,18,20,22,24,26,28 tridecaen 330-dione [manufactured analogously to Example 5] are dissolved in 5 ml. of water and added towards the end of the cooking process or during the subsequent processing of 1 kg. of bon-bon composition and homogeneously worked in.
EXAMPLE 9 Manufacture of carbonic acid-containing cassis-colored refreshing drinks 4 g. of color-preparation containing 40 mg. of 2,6,10, 14,19,23,27,31 octamethyl-2,3 l-dimethoxy-dotriaconta- 4,6,8,10,12,l4,16,18,20,22,24,28 tridecaen 3,30 dione [manufactured analogously to Example 5] are dissolved in 20 ml. of warm water and homogenized with g. of sugar syrup. After the addition of citric acid and aroma tmaterails, the colored solution is diluted to 10 liters with carbonic acid-containing water and filled into botles having stirrup-closures.
EXAMPLE 10 Manufacture of violet-brownish colored suppositories 100 g. of suppository composition are heated with 100 mg. of crystallized 2,6,10,14,19,23,27,31-octamethyl-2,31- dimethoxy-dotriaconta 4,6,25,10,12,14,l6,18,20,22,24,26,
28-tridecaen-3,30-dione up to complete solution of the pigment. u-Tocopherol, BHT, BHA, gallates etc. can be admixed as antioxidants. After working in the active material, the violet fatty composition is poured into the usual molds and allowed to cool.
EXAMPLE 11 Manufacture of violet-colored gelatin capsules Manufacture of raspberry-red syrups and confectionery Per kg. of syrup or confectionery, 2 g. of color-preparation containing 20 mg. of 2,6,10,14,19,23,27,3l-octamethyl 2,3l-dimethoxy-dotriaconta-4,6,8,l0,12,l4,16,- 18,20,22,24,26,28 tridecaen 3,30-dione [manufactured analogously to Example 5] are dissolved warm in 5 ml. of Water and added to the syrup or confectionary composition towards the end of the thickening process.
EXAMPLE 13 Manufacture of Bordeaux-red gelatin foods 2 g. of color-preparation containing 20 mg. of 2,6,10,- n
14,19,23,27,31 octamethyl-2,3l-dimethoxy-dotriaconta- 4,6,8,10,12,14,16,18,20,22,24,26,28 tridecaen-3,30-dione [manufactured analogously to Example 5] are dissolvedin 6 ml. of warm water and stirred into 1 liter of the warm, liquid gelatin solution consisting of the usual ingredients. The solution is poured into molds and allowed to cool.
EXAMPLE 14 Manufacture of a weekly violet-colored daytime cream 1 g. of color-preparation containing mg. of 2,6,10,- 14,19,23,27,31 octamethyl-2,31dimethoxy-dotriaconta- 4,6,8,l0,l2,l4,l6,l8,20,22,24,26,28 tridccaen 3,30 dione [manufactured analogously to Example 5] is dissolved in 65 ml. of warm water. The solution is emulsified in a salve base which consists of 15 g. of cetyl alcohol and octadecyl alcohol 3 g. of spermaceti, 1 g. of butyl stearate, 1 g. of lanolin, 5 g. of Cetiol, 2.8 g. of Carol, 8 g. of glycerin or propyleneglycol and 0.5 g. of perfume oil composition.
EXAMPLE 15 Manufacture of a raspberry-colored pudding composition 2 g. of color-preparation containing mg. of 2,6,10,- 14,19,23,27,31 octamethyl-2,3 l-dimethoxy-dotriaconta- 10 4,6,8,10,12,14,16,l8,20,22,24,26,28 tridecaen-3,30-dione [manufactured analogously to Example 5] are admixed with the pudding powder sufiicient for 1 liter of completely prepared pudding and [the mixture] further processed as usual by stirring or boiling up with milk.
EXAMPLE 16 Manufacture of Bordeaux-red colored yogurt 2 g. of color-preparation containing 20 mg. of 2,6,10,- 14,19,23,27,31 octarnethyl-2,3l-dimethoxy-dotriaconta- 4,6,8,10,12,14,l6,18,20,22,24,26,28 tridecaen-3,30-dione [manufactured analogously to Example 5] are dissolved warm in 5 ml. of water, mixed with 1 liter of milk and [the mixture] processed in the usual manner to [give] yogurt.
EXAMPLE 17 Manufacture of a Bordeaux-red marzipan composition 10 mg. of crystalline 2,6,l0,14,19,23,27,3l-octamethyl- 2,31 dimethoxy-dotriaconta-4,6,8,10,12,14,16,18,20,22,- 24,26,28-tridecaen-3,30-dioue are dissolved hot in 10 g. of almond oil, and, while still warm, worked into 1 kg, of marzipan composition manually or by machine. The marzipan composition can, if desired also be colored with a water-soluble pigment preparation which, dissolved in a little water, is admixed with the marzipan composition.
EXAMPLE 18 Manufacture of a pale Bordeaux-red colored toothpaste 0.5 g. of pigment powder containing 5 mg. of 2,6,10,- l4,l9,23,27,31 octamethyl-2,3l-dimethoxy-dotriaconta 4,6,8,10,12,14,16,18,20,22,24,26,28 tridecaen-3,30-dione [manufactured analogously to Example 5] are dissolved in 2 ml. of water and homogeneously worked into g. of white toothpaste of the usual composition. The same pigment preparation can also be added, if desired, to the raw materials which are dissolved in water or converted into a paste with water.
What is claimed is:
1. Compounds of the formula wherein R is selected from the group consisting of hydrogen and a lower alkyl group.
2. 2,6,l0,14,l9,23,27,31 octamethyl-2,3l-dimethoxydotriaconta 4,6,8,10,12,14,18,20,22,24,26,28 docecaen- 16-yne-3,30-dione.
3. 2,6,10,14,l9,23,27,3l octamethyl-2,3l-dihydroxydotriaconta 4,6,8,10,12,14,18,20,24,26,28 docecaen-16- yne-3,30-dione.
References Cited Jackman: Acta. Chem. Scand., vol. 18(6), pp. 1404- 1411 (1964).
Raphael: Adv. in Org. Chem, vol. 4, pp. 186 and 190- 192 (1963).
BERNARD HELFIN, Primary Examiner W. B. LONE, Assistant Examiner
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH123366 | 1966-01-28 |
Publications (1)
Publication Number | Publication Date |
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US3539643A true US3539643A (en) | 1970-11-10 |
Family
ID=4205588
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US609312A Expired - Lifetime US3539643A (en) | 1966-01-28 | 1967-01-16 | Polyene compounds |
US819524A Expired - Lifetime US3659024A (en) | 1966-01-28 | 1969-04-24 | Use of certain polyenes as coloring agents |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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US819524A Expired - Lifetime US3659024A (en) | 1966-01-28 | 1969-04-24 | Use of certain polyenes as coloring agents |
Country Status (6)
Country | Link |
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US (2) | US3539643A (en) |
BE (1) | BE693073A (en) |
DE (1) | DE1301238B (en) |
ES (1) | ES336152A1 (en) |
GB (1) | GB1145213A (en) |
NL (1) | NL6700551A (en) |
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WO2022149070A1 (en) * | 2021-01-05 | 2022-07-14 | C-Care, Llc | Unit dose article for adding a cosmetic function to a cosmetic base product |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
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DE1090658B (en) * | 1957-10-18 | 1960-10-13 | Hoffmann La Roche | Process for the production of polyene aldehydes |
-
1966
- 1966-12-14 DE DEH61274A patent/DE1301238B/en active Pending
-
1967
- 1967-01-13 NL NL6700551A patent/NL6700551A/xx unknown
- 1967-01-16 US US609312A patent/US3539643A/en not_active Expired - Lifetime
- 1967-01-24 BE BE693073D patent/BE693073A/xx unknown
- 1967-01-27 ES ES336152A patent/ES336152A1/en not_active Expired
- 1967-01-27 GB GB4191/67A patent/GB1145213A/en not_active Expired
-
1969
- 1969-04-24 US US819524A patent/US3659024A/en not_active Expired - Lifetime
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Also Published As
Publication number | Publication date |
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GB1145213A (en) | 1969-03-12 |
DE1301238B (en) | 1969-08-14 |
BE693073A (en) | 1967-07-24 |
US3659024A (en) | 1972-04-25 |
NL6700551A (en) | 1967-07-31 |
ES336152A1 (en) | 1968-04-01 |
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