US3519691A - O-hemiacetals of formaldehyde and catalytic process of manufacture - Google Patents
O-hemiacetals of formaldehyde and catalytic process of manufacture Download PDFInfo
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- US3519691A US3519691A US471759A US3519691DA US3519691A US 3519691 A US3519691 A US 3519691A US 471759 A US471759 A US 471759A US 3519691D A US3519691D A US 3519691DA US 3519691 A US3519691 A US 3519691A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/48—Preparation of compounds having groups
- C07C41/50—Preparation of compounds having groups by reactions producing groups
- C07C41/56—Preparation of compounds having groups by reactions producing groups by condensation of aldehydes, paraformaldehyde, or ketones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- the process of the present invention relates to a catalyzed process of making O-hemiacetals of formaldehyde and the products obtained thereby.
- hemiacetals are formed as intermediate products in the usual preparation of acetals from aldehydes and alcohols.
- the formation of he'miacetal is indicated by changes in the refractive index and specific gravity of the alcoholaldehyde mixture and by the disappearance of the carbonyl grouping as shown by adsorption spectra.
- hemiacetals are difficult to isolate and decompose on heating. I
- An object of the present invention is to obtain O-hemiacetals of formaldehyde by the reaction of anhydrous liquid or gaseous formaldehyde with compounds and polymers having at least one hydroxyl group where the reaction mixture contains a catalyst.
- O-hemiacetals of formaldehyde and high molecular weight and high melting point compounds by dissolving the high molecular weight and high melting point compound in a solvent and by adding a catalyst to the reaction mixture.
- the O-hemiformals If kept in open vessels, the O-hemiformals gradually give off formaldehyde. This property makes them especially useful as disinfectants and insecticides.
- the O-hemiformals because of their chemical reactivity, also form useful intermediaries for organic syntheses. Bisand polyformals are suitable components for the production of synthetic resins, lacquers and adhesives.
- alkalis such as sodium or potassium hydroxide
- hemiformal mixtures are obtained without the liberation of water or the formation of complete acetals, cyclic acetals or polyformals.
- the catalysis with alkalis is necessary here for the depolymerization of the paraformaldehyde and cannot be substituted by strong tertiary organic bases such as triethylamine or tri-n-butylamine.
- the re action with paraformaldehyde in the presence of alkali occurs however with appreciable velocity only at higher temperatures (SO- C.) where the reaction is vigorously exothermal and is difficult to control on a large scale.
- Uncontrollable amounts of formaldehyde are then set free and result in part to a polyaddition of the formaldehyde to an already present hemiformal and therefore produce mixtures.
- Hemiacetals of formaldehyde also may be produced in a very simple manner by a process not known in the prior art by introducing pure formaldehyde slowly and with cooling according to the speed of the reaction, into a substituted or unsubstituted monoor polyvalent alcohol which may be of high molecular weight and dissolved in an inert solvent, in such a manner that the reaction temperature will be at least 20 C. above and preferably 50 to C., above the boiling point of the pure form- 3 aldehyde, and with the concentration of free formaldehyde during the reaction not exceeding 8%, preferably not Experience has shown that the formation of O-hemiformals often occurs at only moderate speed, and sometimes so slowly that it could not be referred to as a reaction at all.
- hemiacetals of formaldehyde are produced at a greatly increased rate by reacting formaldehyde with an unsubstituted or even a substituted monoor polyvalent and possibly high molecular weight alcohols in the presence of an acid or a phosphine, arsine, stibine or nitrogenous compound.
- Suitable nitrogenous compounds are a N-methylol compound, a N-methylol ether, an amide or its derivative, an imino ether, a hydrazine derivative, 9. dithiocarbamic acid derivative or a quaternary ammonium compound, while suitable acid compounds are conc. sulfuric acid, perchloric acid, hydrochloric acid, p-toluene-sulfonic acid, or Lewis acids such as BF BF -etherate, or oxonium fluoboratc.
- Suitable catalysts which can be used in amounts of 0.00001% to 2% relative to the Weight of the added alcohol are especially the tertiary, secondary and primary amines such as triethylamine, tri-n-butylamine, pyridine, piperidine, diethyl-amine, cyclohexyl-methylamine, butylamine, N-methyl-aniline, cyclohexylamine, isoamylamine and tri-n-octylamine, phosphines such as triphenylphosphine and tri-n-butylphosphine, stibines such as tri-n-butyl-stibine, arsines such as tri-n-butylarsine, and quaternary ammonium compounds such as tetramethyl ammonium bromide.
- the tertiary, secondary and primary amines such as triethylamine, tri-n-butylamine, pyridine, piperidine, diethyl
- the catalyst is preferably introduced into the alcohol, whereupon the formaldehyde is added.
- the reaction which occurs with the liberation of heat and which therefore requires effective cooling, succeeds especially well if the formaldehyde is introduced in gaseous form.
- reactions which are performed at temperatures below the boiling point of monomeric formaldehyde (21 C.) in liquid form, only at the rate at which it is used up.
- the greatly increased reaction velocity resulting from the use of the catalyst it is now possible in technical processes to introduce the formaldehye at a rate which would ordinarily be difficult or impossible without danger of producing undesired side-products such as paraformaldehye.
- the reaction is advantageously performed at temperatures between 100 and +150 C., preferably between -20 and +130 C., and best at 30 C.
- Especally pure O-hemiacetals are obtained if a pure water-free formaldehyde is introduced which is sufficiently free from ionized impurities not to polymerize.
- the formaldehyde can, if desired, be diluted with an inert gas such as nitrogen, argon, neon, xenon and krypton.
- an inert gas such as nitrogen, argon, neon, xenon and krypton.
- solid alcohols or pehonls are preferably used in the molten condition, provided the melting point is not higher than about 150 C. and a further reaction of the hemiforrnal will not occur, which would naturally depend on the nature of the alcohol or phenol.
- Compounds which melt at higher temperatures are preferably dissolved in a solvent which can form concentrated solutions of the alcohol, the formaldehyde being then allowed to react with the alcohol at lower temperatures.
- Suitable solvents for the high melting point compounds are ethers such as diethyl ether, diisopropyl ether, di-n-butyl ether, methyl-ethyl ether, hydrocarbons such as n-propane, n-butane, n-pentane, n-hexane, and n-decane, as well as mixtures such as petroleum ether, ligroin, aromatics such as benzene, xylene, anisol or mixtures thereof, and chlorinated hydrocarbons such as carbon tetrachloride, chloroform, tetrachlorethane, trichlorethylene and methylene chloride.
- ethers such as diethyl ether, diisopropyl ether, di-n-butyl ether, methyl-ethyl ether, hydrocarbons such as n-propane, n-butane, n-pentane, n-hexane
- Suitable alcohols for reaction with formaldehyde are, e.g. methanol, ethanol, n-propanol, n-butanol, isobutyl alcohol, n-amyl alcohol, isoamyl alcohol, n-hexyl alcohol, n-he'ptanol, n-oxtyl alcohol, n-dexyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, benzyl alcohol, cyclohexanol, diethylene-glycol-monoethylether, triethylene glycol monoethyl ether, triethyleneglycol-monobutyl-ether, 1,2 propylene-glycol-l-n-butylether, ethylene-glycol monomethyl ether, isopropanol, sec.
- butyl alcohol tert. butyl alcohol, sec. amyl alcohol, tert. amyl alcohol, 6-ethy-decanol-(3), S-ethyl-heptanol- (2), S-ethyl-nonanol-(Z), and 6-ethyl-octanol-(3).
- Suitable compounds are, e.g. allyl alcohol, endomethylene-tetrahydro-benzyl-alcohol, ethylene chlorhydrin, 2-ethyl-3-hydroxy-hexanal, ethylene-glycol-monoacrylate, propylene-glycol-monoacrylate, and propyleneglycol-monomethacrylate.
- Suitable polyhydroxy alcohols for reaction with formaldehyde are, e.g. glycol, propylene-glycol-1,2, propyleneglyco1-1,3, -butane-dio1-1,4, pentane-diol-1,5, 1,4-butenediol, 2,Z-dimethyl-propane-diol-( 1,3 hexane-diol- 1,6) decane-diol-(1,l0), diethylene-glycol, triethylene-glycol, thiodiglycol, triethanolamine, thioglycol sulfoxide, 3- amino-2,5 dimethyl-hexane-diol-(2,5), 3,5-bis (oxyisopropyl)-pyridine, hexane dien-(2,4)-diol-( 1,6), and other diols in which the carbon chain contains a double bond or a triple bond, also glycerol, hexane-
- phenols such as phenol, o-cresol, m-cresol, p-cresol, 0-, mand p-chlorphenol, p-bromphenol, o-, mand p-nitrophenol, 2,4-dinitrophenol, guaiacol, cyclohexanol, eugenol, saligenine, o-oxy-acetophenone, o-cyclo-hexyl-phenol, pyrocatechol, resorcinol, hy-
- EXAMPLE 12 In the same apparatus used. in Examples 1 to 7, but provided with a reflux cooler, 330.3 parts resorcinol are dissolved in 1656 parts ether, 0.1 part triphenylphosl5 phine is added, and at C. 180 parts by weight of formaldehyde are conducted in during 95 minutes vwith vigorous stirring and intense cooling. The ether-is distilled off under a water aspirator vacuum while the sump temperature is not allowed to rise above 20 C. 506 parts- 20 of a strongly viscous clear liquid are .obtained which is shown by elementary analysisand infra-red spectroscopy to be resorcin-bis-hemiforrnal. v I
- a liquid comprising an organic compound containing at least one hydroxyl group, selected from the group consisting of alcohols and phenols;
- the improvement comprising conducting said reaction with cooling at a temperature between 100 and 150 C. in the presence of a catalytic quantity of a catalyst selected from the group consisting of concentrated sulfuric acid, perchloric acid, hydrochloric acid, p-toluene-sulfonic acid, BF BF -ether ate, oxonium fiuoborate, triethylamine, tri-n-butylamine, pyridine, piperidine, diethylamine, cyclohexylethylamine, butylamine, N-methyl-aniline, cyclohexylamine, isoamylamine, tri-n-octylamine, triphenylphosphine, tri-n-butylphosphine, tri-n-butyl-stibine, tri-n-butyl-arsine, tetramethyl ammonium bromide, and mixtures thereof.
- a catalyst selected from the group consisting of concentrated sulfuric acid, perch
- organis compound containing at least one hydroxyl group is 7 selected from the group consisting of tertiary butanol,
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Description
United States Patent Office US. Cl. 260-611 11 Claims ABSTRACT OF THE DISCLOSURE Several novel O-hemiacetals useful as convenient sources of formaldehyde, etc., and a novel improved method of making O-hemiacetals of formaldehyde comprising (a) adding gaseous formaldehyde to: (b) a liquid comprising an organic compoundcontaining one hydroxyl group; and (c) reacting (a) and (b) with vigorous and sufiicient agitation to insure uniform distribution of said formaldehyde and cooling at a temperature between 100 and 150 C., the rate of adding said formaldehyde being sufficiently slow so that the concentrationof free formaldehyde in the solution does not exceed 8%, the improvement comprising conducting the reaction in the presence of a catalytic quantity of a catalyst selected from the group consisting of acids, phosphines, arsines, stibines, nitrogenous compounds and mixtures thereof.
The process of the present invention relates to a catalyzed process of making O-hemiacetals of formaldehyde and the products obtained thereby.
As disclosed in Kirk-Othmer, Encyclopedia of Chemical Technology, 2nd edition (1963), vol. 1, pp. 107-109, hemiacetals are formed as intermediate products in the usual preparation of acetals from aldehydes and alcohols. The formation of he'miacetal is indicated by changes in the refractive index and specific gravity of the alcoholaldehyde mixture and by the disappearance of the carbonyl grouping as shown by adsorption spectra. According to the prior art, hemiacetals are difficult to isolate and decompose on heating. I
An object of the present invention is to obtain O-hemiacetals of formaldehyde by the reaction of anhydrous liquid or gaseous formaldehyde with compounds and polymers having at least one hydroxyl group where the reaction mixture contains a catalyst.
It is a particular object of the present invention to increase and control the speed of reaction of formaldehyde with monovalent and polyhydric alcoholssuch' as those disclosed in Kirk-Othmer, Encyclopedia of Chemical Technology, 2nd edition (1963), vol. 1, pp. 531-638, by the addition of a catalyst to the reaction mixture.
Other objects of the present invention are to form O-hemiacetals of formaldehyde and high molecular weight and high melting point compounds by dissolving the high molecular weight and high melting point compound in a solvent and by adding a catalyst to the reaction mixture. v
If kept in open vessels, the O-hemiformals gradually give off formaldehyde. This property makes them especially useful as disinfectants and insecticides. The O-hemiformals, because of their chemical reactivity, also form useful intermediaries for organic syntheses. Bisand polyformals are suitable components for the production of synthetic resins, lacquers and adhesives.
According to the prior art disclosures of hemiacetal processes, pure hemiacetals have not been obtained free from alcohol or aldehyde residues, polymeric aldehydes, addition products of hemiacetals and aldehydes, complete acetals, etc. i
3,519,691 Patented July 7, 1970 With reference to formaldehyde, which as the first member of a homologous series has moreover divergent properties, it has lately been assumed (J. F. Walker, Formaldehyde, Reinhold Publishing Corp., New York (1964), p. 264, lines 9-10), that the equilibrium between formaldehyde and alcohol is much further on the side of the hemiformal than with other aldehydes.
For the production of hemiformals it has been variously suggested by the prior art that this may be accomplished by reacting aqueous formaldehyde solutions with alcohols, followed by removal of the water from the hemiformals. Such a process, however, is very tedious and can be performed in only certain cases. It also generally produces hemiformal mixtures containing besides the hemiformal, also alcohol, some residual water, formaldehyde and polyhemiformals.
According to the prior art, it is known that instead of formaldehyde solutions, it is possible to react para formaldehyde in the presence of catalysts with monoor polyvalent alcohols. In the presence of acids such as p-toluene-sulfonic acid or Lewis acids such as boron fluoride, there is then generally obtained from simple alcohols only the corresponding complete acetal with separation of the water, from simple diols such as glycol, 1,3-propane-diol, and 1,4-butane-diol only the corresponding cyclic acetals, while with higher homologous diols such as 1,5-pentane-diol, 1,7-heptane-diol, and 1,10- decane-diol the corresponding straight-chain polyformals with the liberation of water. On the other hand, in the presence of alkalis such as sodium or potassium hydroxide, hemiformal mixtures are obtained without the liberation of water or the formation of complete acetals, cyclic acetals or polyformals. The catalysis with alkalis is necessary here for the depolymerization of the paraformaldehyde and cannot be substituted by strong tertiary organic bases such as triethylamine or tri-n-butylamine. The re action with paraformaldehyde in the presence of alkali occurs however with appreciable velocity only at higher temperatures (SO- C.) where the reaction is vigorously exothermal and is difficult to control on a large scale. Uncontrollable amounts of formaldehyde are then set free and result in part to a polyaddition of the formaldehyde to an already present hemiformal and therefore produce mixtures. By the depolymerization of the formaldehyde there is a liberation of about.5% water,
depending on the composition of the material, which.
properties are produced, see for example, concurrently filed application, Ser. No. 471,702 and 471,761 of July 13,1965 which as filed refer to this application and describe industrially useful. polycondensates made on the basis of the O-hemiacetals of thisinvention.
Hemiacetals of formaldehyde also may be produced in a very simple manner by a process not known in the prior art by introducing pure formaldehyde slowly and with cooling according to the speed of the reaction, into a substituted or unsubstituted monoor polyvalent alcohol which may be of high molecular weight and dissolved in an inert solvent, in such a manner that the reaction temperature will be at least 20 C. above and preferably 50 to C., above the boiling point of the pure form- 3 aldehyde, and with the concentration of free formaldehyde during the reaction not exceeding 8%, preferably not Experience has shown that the formation of O-hemiformals often occurs at only moderate speed, and sometimes so slowly that it could not be referred to as a reaction at all.
In the reference of Houben-Weyl, vol. VII, Part 1 (1954), p. 416, it is stated that the formation of hemiformals is not influenced by the presence of catalysts.
On the other hand, according to other prior art references, the conversion of practically water-free formaldehyde with anionic catalysts such as amines or phosphines, or with cationic catalysts, e.g. Lewis acids such as boron fluoride, are preferred methods of producing high molecular weight polyoxymethylenes.
According to the present invention, applicant has discovered the neW and unexpected result that hemiacetals of formaldehyde are produced at a greatly increased rate by reacting formaldehyde with an unsubstituted or even a substituted monoor polyvalent and possibly high molecular weight alcohols in the presence of an acid or a phosphine, arsine, stibine or nitrogenous compound. Suitable nitrogenous compounds are a N-methylol compound, a N-methylol ether, an amide or its derivative, an imino ether, a hydrazine derivative, 9. dithiocarbamic acid derivative or a quaternary ammonium compound, while suitable acid compounds are conc. sulfuric acid, perchloric acid, hydrochloric acid, p-toluene-sulfonic acid, or Lewis acids such as BF BF -etherate, or oxonium fluoboratc.
Under the reaction conditions of this process such catalayts will greatly accelerate the formation of hemiformals and in some cases will make their production possible.
Suitable catalysts which can be used in amounts of 0.00001% to 2% relative to the Weight of the added alcohol are especially the tertiary, secondary and primary amines such as triethylamine, tri-n-butylamine, pyridine, piperidine, diethyl-amine, cyclohexyl-methylamine, butylamine, N-methyl-aniline, cyclohexylamine, isoamylamine and tri-n-octylamine, phosphines such as triphenylphosphine and tri-n-butylphosphine, stibines such as tri-n-butyl-stibine, arsines such as tri-n-butylarsine, and quaternary ammonium compounds such as tetramethyl ammonium bromide.
The catalyst is preferably introduced into the alcohol, whereupon the formaldehyde is added. The reaction, which occurs with the liberation of heat and which therefore requires effective cooling, succeeds especially well if the formaldehyde is introduced in gaseous form. In reactions which are performed at temperatures below the boiling point of monomeric formaldehyde (21 C.) in liquid form, only at the rate at which it is used up. With the greatly increased reaction velocity resulting from the use of the catalyst, it is now possible in technical processes to introduce the formaldehye at a rate which would ordinarily be difficult or impossible without danger of producing undesired side-products such as paraformaldehye.
For the same reason, it is advantageous to quickly disperse the introduced formaldehyde by rapid stirring.
The reaction is advantageously performed at temperatures between 100 and +150 C., preferably between -20 and +130 C., and best at 30 C.
Especally pure O-hemiacetals are obtained if a pure water-free formaldehyde is introduced which is sufficiently free from ionized impurities not to polymerize.
The formaldehyde can, if desired, be diluted with an inert gas such as nitrogen, argon, neon, xenon and krypton.
Under normal conditions solid alcohols or pehonls are preferably used in the molten condition, provided the melting point is not higher than about 150 C. and a further reaction of the hemiforrnal will not occur, which would naturally depend on the nature of the alcohol or phenol. Compounds which melt at higher temperatures are preferably dissolved in a solvent which can form concentrated solutions of the alcohol, the formaldehyde being then allowed to react with the alcohol at lower temperatures. Suitable solvents for the high melting point compounds are ethers such as diethyl ether, diisopropyl ether, di-n-butyl ether, methyl-ethyl ether, hydrocarbons such as n-propane, n-butane, n-pentane, n-hexane, and n-decane, as well as mixtures such as petroleum ether, ligroin, aromatics such as benzene, xylene, anisol or mixtures thereof, and chlorinated hydrocarbons such as carbon tetrachloride, chloroform, tetrachlorethane, trichlorethylene and methylene chloride.
Suitable alcohols for reaction with formaldehyde are, e.g. methanol, ethanol, n-propanol, n-butanol, isobutyl alcohol, n-amyl alcohol, isoamyl alcohol, n-hexyl alcohol, n-he'ptanol, n-oxtyl alcohol, n-dexyl alcohol, lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, benzyl alcohol, cyclohexanol, diethylene-glycol-monoethylether, triethylene glycol monoethyl ether, triethyleneglycol-monobutyl-ether, 1,2 propylene-glycol-l-n-butylether, ethylene-glycol monomethyl ether, isopropanol, sec. butyl alcohol, tert. butyl alcohol, sec. amyl alcohol, tert. amyl alcohol, 6-ethy-decanol-(3), S-ethyl-heptanol- (2), S-ethyl-nonanol-(Z), and 6-ethyl-octanol-(3).
It is also possible for compounds which in addition to the hydroxyl function also contain one or more reactive double bonds, triple bonds, one or more epoxy-, nitrile-, nitroor methoxy groups, or one or more halogen functions, to be reacted with formaldehyde in the presence of the named catalysts to form the corresponding hemiformals without in any manner changing the remainder of the molecule. Suitable compounds are, e.g. allyl alcohol, endomethylene-tetrahydro-benzyl-alcohol, ethylene chlorhydrin, 2-ethyl-3-hydroxy-hexanal, ethylene-glycol-monoacrylate, propylene-glycol-monoacrylate, and propyleneglycol-monomethacrylate.
Suitable polyhydroxy alcohols for reaction with formaldehyde are, e.g. glycol, propylene-glycol-1,2, propyleneglyco1-1,3, -butane-dio1-1,4, pentane-diol-1,5, 1,4-butenediol, 2,Z-dimethyl-propane-diol-( 1,3 hexane-diol- 1,6) decane-diol-(1,l0), diethylene-glycol, triethylene-glycol, thiodiglycol, triethanolamine, thioglycol sulfoxide, 3- amino-2,5 dimethyl-hexane-diol-(2,5), 3,5-bis (oxyisopropyl)-pyridine, hexane dien-(2,4)-diol-( 1,6), and other diols in which the carbon chain contains a double bond or a triple bond, also glycerol, hexane-trio], dioxyacetone, pentaerythrite, polyoles such as polyvinyl alcohol, cis-transand 1:1 cis/trans mixtures of 2,2,4,4-tetramethyl 1,3 cyclohexane dirnethanol 1,4,2,5- or 2,6- norbornene diol, also ether-group containing diols such as:
Especially useful for reaction with formaldehyde to form hemiacetals are phenols such as phenol, o-cresol, m-cresol, p-cresol, 0-, mand p-chlorphenol, p-bromphenol, o-, mand p-nitrophenol, 2,4-dinitrophenol, guaiacol, cyclohexanol, eugenol, saligenine, o-oxy-acetophenone, o-cyclo-hexyl-phenol, pyrocatechol, resorcinol, hy-
-droquinone, pyrogallol, oxyhydroquinone, o-, mand paminophenol.
It is also possible to obtain lower hemiformals of polyvalent alcohols by introducing only as much formaldehyde as is needed for reaction with only one of the hydroxyl groups of diols, or with two of the hydroxyl groups of triols. The same alcohols can be used here as have already been described for use in the production of polyvalent hemiformals.
This new process is not limited, however, to hydroxyl Elementary Analysis Density, Calculated Found 20 Refractive D Index, 4 n ,20 1. 2680 1. 4671 9. 96 31. 67 1.4755 7. 81 52. 94 1. 2777 1. 4609 EXAMPLES 8 TO out catalysts. In the latter cases no reaction occurs at but only bubbles through. The catalyzed reaction is quan- In the Same apparatus used in Examples 1 to 7, form the low temperatures indicated. The formaldehyde which titative and occurs with the liberation of much heat, aldehyde is reacted as indicated in Table II. Comparisons is conducted into the alcohol 18 not absorbed thereby which is conducted away. are again made of hemiformal production with and with- TABLE II Molecular Formalde- Formaldehyde Con- Weight hyde, Reaction Introduction vercalcu- Calparts Temp., time in sion latcd cu- Alcohol, parts by weight by weight 8 0. Catalyst, parts minutes g./h. forlated Found li-lluty amne,0.05 140 CH 0 a 122.12 130 W 120 50 50 -.*..f3 f-.. ...if???-ififfffifffi.iii 10 Gl $170,513) 184 2 gggbutylarmnei 22:11:: ag 144 C H O 204. 26 212 58.80 9. 87 31.33 58. 60 4 Ycem i 180 40 Triethylarnine, 95 270 0,111.6. ise a iss5536 =Formaldehyde. b =No formaldehyde absorption. 0 Glycerol-mono-hemiformal.
8....-. Glycerol 644.6 9.--. Cyclohexane-dimethanol (50% EXAMPLE 11 In the same apparatus used in Examples 1 to 7, 148.2 parts tert. butanol and 0.1 part BF -etherate are mixed and heated to 82 C. 60 parts formaldehyde are con- 5 ducted into the mixture in the course of 35 minutes while the temperature is kept at 82 C. by intense cooling. There is produced butanol hemiformal as a clear, limpid liquid which, however, decomposes in 2 to 12 hours with the separation of paraformaldehyde.
EXAMPLE 12 In the same apparatus used. in Examples 1 to 7, but provided with a reflux cooler, 330.3 parts resorcinol are dissolved in 1656 parts ether, 0.1 part triphenylphosl5 phine is added, and at C. 180 parts by weight of formaldehyde are conducted in during 95 minutes vwith vigorous stirring and intense cooling. The ether-is distilled off under a water aspirator vacuum while the sump temperature is not allowed to rise above 20 C. 506 parts- 20 of a strongly viscous clear liquid are .obtained which is shown by elementary analysisand infra-red spectroscopy to be resorcin-bis-hemiforrnal. v I
From the foregoing description, one skilled in the art can easily ascertain theessential characteristics of this invention, and withoutdeparting from the spirit and scope thereof, can make various changes and modifica-' tions of theinvention to adapt itto various usages and conditions.Consequently, such changes and modifications are properly, equitably, and intendedto be, within the full range of equivalence of the following claims.
What is claimed is:
1. In a method of making O-hemiacetals of formaldehyde comprising: 1
(a) adding gaseous formaldehyde to:
(b) a liquid comprising an organic compound containing at least one hydroxyl group, selected from the group consisting of alcohols and phenols; and
(c) reacting (a) and (b) with vigorous and suflicient agitation to insure uniform distribution of said formaldehyde, the rate of adding said formaldehyde being sufficiently slow so that the concentration of free formaldehyde in the solution does not exceed 8%,
the improvement comprising conducting said reaction with cooling at a temperature between 100 and 150 C. in the presence of a catalytic quantity of a catalyst selected from the group consisting of concentrated sulfuric acid, perchloric acid, hydrochloric acid, p-toluene-sulfonic acid, BF BF -ether ate, oxonium fiuoborate, triethylamine, tri-n-butylamine, pyridine, piperidine, diethylamine, cyclohexylethylamine, butylamine, N-methyl-aniline, cyclohexylamine, isoamylamine, tri-n-octylamine, triphenylphosphine, tri-n-butylphosphine, tri-n-butyl-stibine, tri-n-butyl-arsine, tetramethyl ammonium bromide, and mixtures thereof.
2. The method of claim 1, wherein the catalyst is butylamine.
3. The method of claim 1, wherein the catalyst is tri-n-butylamine. I
4. The method of claim 1, wherein the catalyst is borontrifluoricle etherate.
Q 5. The method of claim 1, wherein the catalyst is piperidine. i u 1 6. The method of claim 1, wherein the catalystis triethylamine. a A
7. A method as defined by claim 1 wherein said catalyst is present in an amount of .0.OOQ1% to 2% relative to the weight of said organic compound containing at least one hydroxyl group. v
8. The method of claim 1 wherein the catalyst is tripheuyl-phosphine. I m
v 9. A process. as defined by claim 1 wherein said organis compound containing at least one hydroxyl group is 7 selected from the group consisting of tertiary butanol,
resorcinol, hydroquinone, pyrogallol and tertiary amyl alcohol.
10. The O-hemiacetal of cyclohexane-dimethanol and formaldehyde.
11. The di-O-hemiacetal of cyclohexane-dimethanol and formaldehyde.
References Cited UNITED STATES PATENTS 2,333,927 11/1943 Harvey.
10 OTHER REFERENCES Walker, Formaldehyde (1944) pp. 37-38.
Raff et al. Canadian Journal of Chemistry (1951) pp.
UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3 519, 691 Dated Jul! 7 1970 t fl HANS VON PORTATIUS It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:
-C H to ---C H Column 4, Line 53, change 6 Column 4, Line 56, change "CH to ---CH 5mm an amen Q Attest:
Edward M. Flamlnr, It.
USCOMM-DC 60376-P59 FORM PO-OSO (10-69) a u s, covurmzm rnm'rmc orncr; nu O-JSi-Jlb
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEC33484A DE1241432B (en) | 1964-07-24 | 1964-07-24 | Process for the production of O-hemiacetals of formaldehyde |
| DE1241432 | 1964-07-24 |
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| US3519691A true US3519691A (en) | 1970-07-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| US471759A Expired - Lifetime US3519691A (en) | 1964-07-24 | 1965-07-13 | O-hemiacetals of formaldehyde and catalytic process of manufacture |
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| US (1) | US3519691A (en) |
| NL (1) | NL6509599A (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029711A (en) * | 1976-03-31 | 1977-06-14 | Chevron Research Company | 4-Hydroxy-n-butyraldehyde from allyl alcohol and formaldehyde |
| US4029710A (en) * | 1976-03-31 | 1977-06-14 | Chevron Research Company | 4-Alkoxy-N-butyraldehyde preparation |
| WO1988002360A1 (en) * | 1986-10-03 | 1988-04-07 | Exxon Research And Engineering Company | A process for the hydroformylation of sulfur-containing thermally cracked petroleum residua and novel products thereof |
| US20170066976A1 (en) * | 2015-09-08 | 2017-03-09 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US20170066977A1 (en) * | 2015-09-08 | 2017-03-09 | Ecolab Usa Inc. | Hydrocarbon soluble/dispersible hemiformals as hydrogen sulfide scavengers |
| US10196343B2 (en) | 2013-01-30 | 2019-02-05 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US10308886B2 (en) | 2015-04-22 | 2019-06-04 | Ecolab Usa Inc. | Development of a novel high temperature stable scavenger for removal of hydrogen sulfide |
| US10336950B2 (en) | 2016-07-29 | 2019-07-02 | Ecolab Usa Inc. | Antifouling and hydrogen sulfide scavenging compositions and methods |
| US10538710B2 (en) | 2017-07-13 | 2020-01-21 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US11453729B2 (en) * | 2015-01-23 | 2022-09-27 | Se Tylose Gmbh & Co. Kg | Reversibly crosslinked cellulose ethers and process for the production thereof by selective oxidation of vicinal OH groups |
| US11499108B2 (en) | 2019-01-23 | 2022-11-15 | Championx Usa Inc. | Complete removal of solids during hydrogen sulfide scavenging operations using a scavenger and a Michael acceptor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2333927A (en) * | 1942-10-10 | 1943-11-09 | Harvel Res Corp | Tertiary amyl alcohol-formaldehyde condensation product and method for preparing the same |
-
1965
- 1965-07-13 US US471759A patent/US3519691A/en not_active Expired - Lifetime
- 1965-07-23 NL NL6509599A patent/NL6509599A/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2333927A (en) * | 1942-10-10 | 1943-11-09 | Harvel Res Corp | Tertiary amyl alcohol-formaldehyde condensation product and method for preparing the same |
Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029710A (en) * | 1976-03-31 | 1977-06-14 | Chevron Research Company | 4-Alkoxy-N-butyraldehyde preparation |
| US4029711A (en) * | 1976-03-31 | 1977-06-14 | Chevron Research Company | 4-Hydroxy-n-butyraldehyde from allyl alcohol and formaldehyde |
| WO1988002360A1 (en) * | 1986-10-03 | 1988-04-07 | Exxon Research And Engineering Company | A process for the hydroformylation of sulfur-containing thermally cracked petroleum residua and novel products thereof |
| US11339118B2 (en) | 2013-01-30 | 2022-05-24 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US10196343B2 (en) | 2013-01-30 | 2019-02-05 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US10703710B2 (en) | 2013-01-30 | 2020-07-07 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US11453729B2 (en) * | 2015-01-23 | 2022-09-27 | Se Tylose Gmbh & Co. Kg | Reversibly crosslinked cellulose ethers and process for the production thereof by selective oxidation of vicinal OH groups |
| US10308886B2 (en) | 2015-04-22 | 2019-06-04 | Ecolab Usa Inc. | Development of a novel high temperature stable scavenger for removal of hydrogen sulfide |
| US11085002B2 (en) | 2015-04-22 | 2021-08-10 | Championx Usa Inc. | Development of a novel high temperature stable scavenger for removal of hydrogen sulfide |
| CN107949625B (en) * | 2015-09-08 | 2020-10-02 | 艺康美国股份有限公司 | Hydrocarbon soluble/dispersible hemiformals as hydrogen sulfide scavengers |
| US10407626B2 (en) * | 2015-09-08 | 2019-09-10 | Ecolab Usa Inc. | Hydrocarbon soluble/dispersible hemiformals as hydrogen sulfide scavengers |
| US10584286B2 (en) * | 2015-09-08 | 2020-03-10 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| EP3347440A4 (en) * | 2015-09-08 | 2019-05-08 | Ecolab USA Inc. | Hydrogen sulfide scavengers |
| EP3347441A4 (en) * | 2015-09-08 | 2019-05-01 | Ecolab USA Inc. | Hydrocarbon soluble/dispersible hemiformals as hydrogen sulfide scavengers |
| CN107949625A (en) * | 2015-09-08 | 2018-04-20 | 艺康美国股份有限公司 | Hydrocarbon dissolubility/dispersiveness hemiformal as hydrogen sulfide scavenger |
| US20170066977A1 (en) * | 2015-09-08 | 2017-03-09 | Ecolab Usa Inc. | Hydrocarbon soluble/dispersible hemiformals as hydrogen sulfide scavengers |
| US20170066976A1 (en) * | 2015-09-08 | 2017-03-09 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US10336950B2 (en) | 2016-07-29 | 2019-07-02 | Ecolab Usa Inc. | Antifouling and hydrogen sulfide scavenging compositions and methods |
| US10538710B2 (en) | 2017-07-13 | 2020-01-21 | Ecolab Usa Inc. | Hydrogen sulfide scavengers |
| US11499108B2 (en) | 2019-01-23 | 2022-11-15 | Championx Usa Inc. | Complete removal of solids during hydrogen sulfide scavenging operations using a scavenger and a Michael acceptor |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6509599A (en) | 1966-01-25 |
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