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  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
  • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
  • C07D213/30—Oxygen atoms
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
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  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
  • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
  • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
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  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
  • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
  • C07D213/46—Oxygen atoms
  • C07D213/50—Ketonic radicals
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  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
  • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D213/55—Acids; Esters
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  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
  • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
  • C07D213/57—Nitriles
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  • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
  • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
  • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
  • C07D215/14—Radicals substituted by oxygen atoms
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  • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
  • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
  • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
  • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
  • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
  • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
  • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
  • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
  • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
  • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
  • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Definitions

• the present invention concerns and has for its object the provision of new cycloaliphatic amines with 5 to 8 ring-carbon atoms in the cycloaliphatic moiety, which latter contains a single amino group on one ring-carbon atom and on separate ring-carbon atoms at least one heterocyclic aromatic radical or at least one carbocyclic aromatic and two carbocyclic aliphatic or aromatic radicals, but not more than three radicals selected from the group consisting of a heterocyclic aromatic, a carbocyclic aliphatic and a carbocyclic aromatic radical, whereby in the triaryl compounds at least two of the aromatic radicals are separated from the amino-nitrogen atom by at least three ring-carbon atoms, N-oxides and quaternaries thereof and salts of these compounds, as well as methods for their preparation.
• These compounds may contain one or two double bonds in the cycloaliphatic moiety, separated from the amino group by at least 2 single bonds and may be unsubstituted or substituted in the remaining positions thereof available for substitution, for example by lower alkyl or aralkyl, such as methyl, ethyl, nor i-propyl or butyl, benzyl, 1- or 2-phenylethyl, free, etherified or esterified hydroxy, such as lower alkoxy, lower alkanoyloxy, aroyloxy, lower alkane or benzene sulfonyloxy, e.g.
• carbomethoxy or carbethoxy carbamyl, lower alkylor di-lower alkylcarbamyl, e.g. methylor ethyl-carbamyl, dimethylor diethylcarbamyl, or cyano.
• the maino-substituent therein is an unsubstituted or substituted amino group.
• the substituents of the amino ice group are above all lower hydrocarbon radicals that may also be interrupted by hetero atoms, for example, nitrogen, oxygen or sulfur atoms.
• lower hydrocarbon radicals there may be mentioned above all lower alkyl or alkenyl groups, for example, methyl, ethyl, nor i-propyl, straight or branched chain butyl, pentyl, hexyl or heptyl groups bound in any position; allyl or methallyl groups; cycloalkyl or cycloalkenyl radicals, such as cyclopentyl, cyclo'hexyl, cycloheptyl, cyclopentenyl or cyclohexenyl groups; lower aralkyl or aralkenyl radicals, such as benzyl, phenethyl, styryl or 1-phenyl-buten( 1)-yl-( 3 lower alkylene or alkenylene groups such as ethylene, 1,3-propylene, l,4-butylene, 1,5-pentylene, 1,5,2,5- or 1,6-hexylene or 2,6- hept
• Hydrocarbon radicals that are interrupted by hetero atoms are, for example, di-lower alkylamino-lower alkyl or lower alkoxy-lower alkyl radicals, such as l-dimethylor l-diethylamino-ethyl-(Z), -propyl-(3) or butyl- (4) groups, l-methoxyor 1-ethoxy-ethyl-(2) or -propyl- (3) groups, aza-, oxaor thia-alkylene radicals, such as S-aza, 3-oxa or 3-thia-pentylene-(1,5), 3-methylor 3- ethyl-3-aza-pentylene-(1,5), 3-aza-hexylene-( 1,6) or 4- azaor 4-oxa-heptylene-(2,6).
• di-lower alkylamino-lower alkyl or lower alkoxy-lower alkyl radicals such as l-dimethylor l-
• Said amino group is primarily a tertiary amino group, for example a di-lower alkylamino group, such as dirnethylamino, diethylamino, N-methyl-ethylarnino or dipropylamino, and especially a lower alkylene-, aza-alkylene, oxa-alkyleneor thia-alkyleneimino group, such as py-rrolidino, piperidino, piperazino, N-methylpiperazino, morpholino or thiamorpholino.
• a di-lower alkylamino group such as dirnethylamino, diethylamino, N-methyl-ethylarnino or dipropylamino
• a lower alkylene-, aza-alkylene, oxa-alkyleneor thia-alkyleneimino group such as py-rrolidino, piperidino, piperazin
• the heterocyclic aromatic radical is a monoor bicyclic radical containing at most two nitrogen atoms or an oxygen or sulfur atom, such as 2- or 3-pyrryl, 2-, 3- or 4- pyridyl, 2- or 3-indolyl, 2-, 3-, 4- or S-quinolyl, lor 3- isoquinolyl, Z-imidazolyl, 3- or 4-pyridazinyl, 2-, 4- or 5- pyrimidinyl, 2-pyrazinyl, 4-oxazolyl, 2-thiazolyl, 4H-1,2- oxazinyl- (4) 2H-1 ,3-oxazinyl- (2 4H-1 ,3-thiaziny1- (4) Z-quinazolinyl, Z-quinoxalinyl, l-phthalazinyl, 1,5-naphthyridinyl-(Z) or -(4), 2,6- or 2,7-naphthyridinyl-(l), Z-furyl,
• the carbocyclic aromatic radical preferably is also a monoor bicyclic one, such as phenyl, 1- or Z-naphthyl, whereas the carbocyclic aliphatic radical preferably is a monocyclic one, containing especially 5 to 7 ring-carbon atoms, such as the cycloalkyl or cycloalkenyl radicals mentioned above.
• All of the aromatic radicals mentioned may be unsubstituted or substituted in the nucleus by one or more than one of the same or of diflFerent su-bstituents, for example lower alkyl groups, such as those mentioned above, free or functionally converted hydroxy or mercapto groups, such as methoxy, ethoxy, methylenedioxy, methylor ethylmercapto, halogen, e.g. fluorochloro or bromo, trifluoromethyl, amino, especially di-lower alkylamino, e.g. dimethylor diethylamino, or free or functionally converted carboxy of sulfonyl, e.g. carbethoxy or sulfamyl.
• lower alkyl groups such as those mentioned above
• free or functionally converted hydroxy or mercapto groups such as methoxy, ethoxy, methylenedioxy, methylor ethylmercapto, halogen
• the quaternaries are preferably those containing an additional lower alkyl or aralkyl group, e.g. one of these mentioned above, on any tertiary nitrogen atom present.
• the compounds of the invention possess valuable pharmacological properties. Thus, they exhibit some antiintlamma-tory and especially diuretic activity, with negligible effect on potassium excretion, which can be demonstrated in animal tests using, for example, rats and dogs as test objects. This is in contrast to the kaliuresis which may accompany the natriand chloriuresis of known non-mercurial diuretics.
• the compounds of the present invention are, therefore, useful diuretic, especially natriand chloriuretic agents, for example in the treatment of excessive water, sodium and chlorine retention due, for example, to heart failure or kidney conditions. Furthermore, the new compounds are useful as intermediates in the manufacture of other valuable compounds, especially medicines.
• R stands for hydrogen or lower alkyl
• R stands for hydrogen, lower alkyl, di-lower alkylaminoor lower alkyleneimino-lower alkyl or R and R taken together stand for lower alkylene or lower azo-, oxaor thiaalkylene
• each of R and R stands for hydrogen or lower alkyl
• each of R and R stands for cycloalkyl or one of the radicals mentioned for R and R stands for monocyclic carbocyclic or heterocyclic aryl, which latter contains at most two nitrogen atoms or an oxygen or sulfur atom and which aryl radicals are unsubstituted or substituted by lower alkyl, lower alkoxy, halogen, trifiuorome-th-yl or di-lower alkylamino, their 3-hydroxy or -acyloxy derivatives of which the acyl radical is that of a lower fatty acid or a monocyclic, carbocyclic aryl sulfonic
• each of R and R stands for alkyl with up to 4 carbon atoms or R and R taken together stand for 1,4-butylene, 1,5-pentylene, 3-oxa or 3-thia-pentylene-(1,5) or 3-methylor 3-ethyl-3-azapentylene-(l,5)
• each of R and R stands for hydrogen or methyl
• each of R and R stands for phenyl, lower alkyl-phenyl, lower alkoxy-phenyl, halophenyl, trifluoromethyl-phenyl or di-lower alkylamino-phenyl
• R stands for pyridyl or lower alkyl-pyridyl.
• the present invention concerns compounds of the formula CaHs CHr-CH. a -CE C H-Rt U C Ha-CH in which R stands for 1,4-butylene, 1,5-pentylene, 3-oxaor 3-thia-pentylene-(1,5) or 3-methylor 3-ethyl-3-azapentylene-( 1,5) and R stands for pyridyl-(2), pyridyl- (3) or pyridyl-(4) and acid addition salts thereof, which, when given to dogs at a dosage range between about 0.1 and 10 mg./kg./day, preferably at about 5 mg./kg./day, show outstanding diuretic activity, whereas their lower alkyl pyridinium quaternaries show outstanding hypotensive activity in dogs at about the same dosage range.
• the new compounds are prepared by methods in themselves known. Thus, for example, by (a) reducing the condensation product by an arylcycloaliphatic ketone with ammonia or an amine containing at least one hydrogen atom at the nitrogen atom, or (b) reacting a cycloaliphatic aminoketone with an aromatic metal compound and hydrolysing the resulting metal adduct or (c) replacing in an aryl-cycloaliphatic compound a substituent R in the cyloaliphatic ring, which is capable of being converted into amino, by an amino group, and, if desired, introducing into the resulting compounds any substituent disclosed or converting any substituent present by another disclosed substituent.
• the condensation product of an aryl-cycloaliphatic ketone especially with an amine is, for example, an enamine, a Schiif base or an oxirne. It is reduced, advantageously, without being isolated, for example, with catalytically activated hydrogen, i.e. hydrogen in the presence of a suitable catalyst, such as palladium platinum, platinum oxide or Raney nickel, with a complex di-light metal hydride, such as sodium boro-hydride, or with formic acid or also nascent hydrogen.
• a suitable catalyst such as palladium platinum, platinum oxide or Raney nickel
• a complex di-light metal hydride such as sodium boro-hydride
• formic acid or also nascent hydrogen formic acid or also nascent hydrogen.
• An aromatic metal compound is, for example, an alkali metal or Grignard compound, e.g. phenyl or 2- pyridyl lithium or a phenyl, naphthyl or quinolyl magnesium halide.
• an alkali metal or Grignard compound e.g. phenyl or 2- pyridyl lithium or a phenyl, naphthyl or quinolyl magnesium halide.
• the substituent R capable of being converted into amino is, for example, a reactive esterified hydroxyl group, more especially a hydroxyl group esterified with a strong inorganic or organic acid, for example, a halogen atom, such as chlorine or bromine, or an aryl-sulfonyloxy group, such as p-toluenesulfonyloxy. It is converted into an amino group, for example, by reaction with ammonia or a primary or secondary amine or with agents yielding them, such as hexamethylene tetramine, Scange bases or phthalimide salts. In the latter case, the condensation products obtained are, if necessary, split in the usual manner, for example, by hydrolysis or hydrazinolysis.
• a reactive esterified hydroxyl group more especially a hydroxyl group esterified with a strong inorganic or organic acid, for example, a halogen atom, such as chlorine or bromine, or an aryl-sulfonyl
• substituents that may be present may be split off or further substituents may be introduced by known methods.
• a compound that contains on one ring-carbon atom besides the aryl radical a free or esterified hydroxyl group this group can be eliminated with formation of a. double bond.
• Elimination of a free hydroxyl group may be performed, for example, with strong acids, such as sulfuric or phosphoric acid, and elimination of an esterified hydroxyl group, for example, with bases, such as an alkali metal carbonate or pyridine.
• the dehydro compounds thus obtained may be hydrogenated, for example, with catalytically activated hydrogen.
• aryl groups present can be hydrogenated to the corresponding cycloalkyl groups.
• any functional converted hydroxy or carboxy group present may be hydrolyzed or solvolyzed or in any amine obtained a substituent may be introduced into the amino group, if necessary, after conversion into a metal, e.g. alkali metal, derivative thereof.
• a metal e.g. alkali metal, derivative thereof.
• This can be done, for example, by reaction with a reactive ester of an appropriate alcohol, for example, that with a hydrohalic, e.g. hydrochloric, hydrobromic or hydriodic acid, or a sulfonic acid, such as a lower alkane or benzene sulfonic acid, e.g.
• methane, ethane or p-toluene sulfonic acid whereby higher substituted amines or quaternaries are obtained, or by reductive alkylation, i.e. reaction with an appropriate oxo compound and subsequent reduction analogous to the method shown under (a), or by oxidation, for example with hydrogen peroxide, a percarboxylic or sulfonic acid, e.g. peracetic, perbenzoic, monoperphthalic or p-toluene persulfonic acid, in order to obtain the N-oxides.
• a percarboxylic or sulfonic acid e.g. peracetic, perbenzoic, monoperphthalic or p-toluene persulfonic acid
• radicals which can be eliminated by hydrogenolysis for example, amino-substituted by a-arylalkyl e.g. benzyl radicals, the said radicals can be split off in the usual manner by hydrogenolysis.
• reaction are carried out according to standard methods, in the presence or absence of diluents, preferably such as are inert to the reagents and are solvents thereof, of catalysts, condensing or neutralizing agents and/or inert atmospheres, at low temperatures, room temperature or advantageously elevated temperatures, at atmospheric or superatmospheric pressure.
• diluents preferably such as are inert to the reagents and are solvents thereof
• the products of the invention are obtained in the free form or in the form of their salts, depending on the conditions under which the process is carried out; the salts are also included in the present invention.
• Salts that are obtained can be converted into the free bases in known manner, for example, with alkalies or ion ex changers.
• Free bases that are obtained can be converted into salts by reaction with organic or inorganic acids, especially those that are suitable for the formation of therapeutically useful salts.
• Such acids are, for example, hydrohalic acids, e.g.
• hydrochlorieor hydrobromic acid sulfuric, phosphoric, nitric or perchloric acid, aliphatic, alicyclic, aromatic or heterocyclic carboxylic or sulfonic acids, for example, formic, acetic, propionic, succinic, glycollic, lactic, malic, tartaric, citric, ascorbic, maleic, hydroxymaleic, pyroracemic, phenylacetic, benzoic, paminobenzoic, anthranilic, p-hydroxybenzoic, salicylic, p-aminosalicylic, embonic, methanesulfonic, ethanesulfonic, hydroxyethanesulfonic, ethylenesulfonic, halobenzenesulfonic, toluenesulfonic, naphthalenesulfonic or sulfanilic acid, methionine, tryptophane, lysine or arginine.
• salts of the new compounds for example, the picrates
• the bases can also be used for purification of the bases obtained; the bases are converted into salts, the salts are separated and the bases are liberated from the salts.
• a corresponding salt is also intended, provided such is possible or appropriate under the circumstances.
• the compounds of the invention are obtained in the form of various geometrical isomers (epimers) or, if they contain an asymmetrical carbon atom, in the form of racemate mixtures, pure racemates or optical antipodes.
• Epimers or mixtures of racemates obtained may be separated by virtue of the physicochemical differences between the components, for example by crystallization and/or chromatography.
• Racemic starting materials or end products can likewise be resolved into the optical antipodes by known methods, for example, by reaction with optically active acids, separation of the diastereomeric salts and liberation of the bases from the salts.
• the invention further includes any variant of the present process in which an intermediate product obtainable at any stage of the process is used as starting material and any remaining steps are carried out, or the process is discontinued at any stage thereof, or in which the starting materials are formed under the reaction conditions, or in which the reaction components may be used in the form of their salts. Mainly those starting materials should be used in the reactions of the invention that lead to the formation of those compounds indicated above as being especially valuable.
• the starting materials are known or, if they are new, may be prepared by methods in themselves known.
• the 3,4,S-triaryl-cyclohexanone compounds may be prepared by condensation of a 1,2-diaryl-ethanone with a A -1-aryl-2-a1kanoyl-alkene, advantageously in the presence of an alkali metal alcoholate, such as sodium .e'thylate.
• the 3-hydroxy-3,4,S-triaryl-cyclohexanone so obtained may be dehydrated, for example, by the use of a strong acid, and hereupon catalytically hydrogenated to the 3,4,S-triaryl-cyclohexanone.
• a complex di-light metal hydride such as lithium aluminum hydride or sodium borohydride
• a complex di-light metal hydride such as lithium aluminum hydride or sodium borohydride
• a complex di-light metal hydride such as lithium aluminum hydride or sodium borohydride
• a complex di-light metal hydride such as lithium aluminum hydride or sodium boro
• Another method for the preparation of said starting material consists in the aldol condensation of a bis-acyllower alkane, in which the carbonyl groups are separated by at least 2 carbon atoms and which may contain an etherified hydroxy group, e.g. 1,3-dibenzoyl-propane or 1,3-dibenzoyl-2-benzyloxy propane, with a mono arylmethane, e.g. toluene or a picoline, and dihydration of the resulting cycloalkanediol to the corresponding cycloalkadiene.
• a mono arylmethane e.g. toluene or a picoline
• dihydration of the resulting cycloalkanediol to the corresponding cycloalkadiene.
• it does not contain said etherified hydroxy group, it is oxidized, e.g.
• the unsaturated ketone which may be hydrogenated to the corresponding saturated ketone.
• the above dehydration product may be easily hydrolyzed or hydrogenolyzed, e.g. by catatylical hydrogenation, yielding the saturated cyclic alcohol.
• said starting ketones can be obtained directly by Michael-condensation of conjugated 6,5- diaryl-alkadienones, e.g. di-benzylidene-acetone, with a mono-aryl-methane, or by Diels-Alder-condensation, for example, of 1,2-diaryl-ethenes with 1-aryl-1,3-butadienes, epoxydation of the resulting 3,4,5-triaryl-cyclohexene, for example, with hydrogen peroxide, reductive cleavage of the epoxide obtained and, if desired, oxydation of the resulting cyclohexanol to the corresponding ketone.
• Michael-condensation of conjugated 6,5- diaryl-alkadienones e.g. di-benzylidene-acetone
• Diels-Alder-condensation for example, of 1,2-diaryl-ethenes with 1-aryl-1,3-butadienes
• Mono-, diand triaryl-cycloalkanones may also be prepared by subjecting an aryl-alkane-dicarboxylic acid ester, e.g. 'y-pyridyl-pimelic acid or fi,fi'-diphenyl-'ypyridyl-pimelic acid dimethyl ester, to Dieckmann condensation and decarboxylating the resulting cyclic ketoacid, for example, by pyrolysis.
• the same compounds are obtained by subjecting an araliphat-ic diketone, e.g.
• the corresponding cyclopentanone starting material can be prepared according to the Wallach degradation, by bromination of the cyclohexanone compounds, alkalitreatment of the dibromide, decarboxylation and oxidation of the resulting 1-hydroxy-cyclopentane-carboxylic acid.
• the corresponding cycloheptanone may be obtained from the cyclohexanone compounds by ring expansion with diazomethane, Whereas the corresponding cyclooctanol can be obtained by reaction of the enarnine condensation products with ethyl propiolate, hydrolysis, reduction and decarboxylation of the resulting Z-carbethoxycyclooctanone.
• substituents such as alkyl, aralkyl, acyl or cyano groups
• substituents may be introduced into any enarnine condensation product, for example, by reaction with the corresponding halo compounds.
• the same can be done with the cycloaliphatic ketones, which also may undergo aldol condensations for the introduction of substituents followed by dehydration and, if desired, hydrogenation and oxidation.
• the compounds of the invention can be used in the free form or in the form of their salts, for example, for the manufacture of pharmaceutical preparations containing the said compounds in admixture with organic or inorganic, solid or liquid pharmaceutical excipients suitable especially for enteral, but also for parenteral administration.
• Suitable excipients are substances that do not react With the new compounds, for example Water, gelatine, lactose, starch, stearyl alcohol, magnesium stearate, talc, vegetable oils, benzyl alcohols, gums, porpylene glycols, white petroleum jelly and other known medicinal excipients.
• the pharmaceutical preparations may be, for example, tables, dragees or capsules, or in liquid form as solutions, suspensions or emulsions.
• They may be terilized and/or contain adjuvants such as preserving, stabilizing, wetting or emulsifying agents, solutions promoters, salts for regulating the osmotic pressure or buffers. They may further contain other therapeutically valu able substances, such as those described in copending application Ser. No. 522,345 filed Jan. 24, 1966, for example, other diuretics, such as 6-chloro-7-sulfamy1-3,4- dihydro-ZH-1,2,4-benzothiadiazine-l ,l-dioxide.
• the starting material can be prepared as follows: A sodium ethoxide solution is prepared by dissolving 9.6 g. of sodium in 900 ml. of absolute ethanol under nitrogen. 81 g. of 2-phenacyl-pyridine are added with stirring, followed, after dissolution, by the addition of 60 g. of benzalacetone. The vigorously-stirred mixture begins to deposit crystals of the condensation product almost at once. The mixture is stirred 30 minutes with mild external cooling, then the product is separated by filtration, washed with water and dried. Recrystallizations from benzene yield the pure 3-hydroxy3,5-diphenyl 4 (2' pyridyl)- cyclohexanone, M.P.
• a mixture of 30 ml. of 85% phosphoric acid and 10.0 g. of 3-hydroxy-3,5-diphenyl-4-(2-pyridyl)-cyclohexanone is heated on the steam bath with stirring under nitrogen for 1 hour. After cooling, the mixture is poured into water and made alkaline with ammonia. The product is extracted into methylene chloride and the extract dried and evaporated. Heating the residue with cyclohexane causes crystallization of a mixture of the threo and erythro isomers of 3,5-diphenyl-4-(2-pyridyl)-cyclohexen-2-one, which after recrystallizations from cyclohexane melt at about 122-125".
• EXAMPLE 3 A suspension of 3.43 g. of 3-hydroxy-3,5-diphenyl-4- (2'-pyridyl)-cyclohexanone, 0.5 g. of platinum oxide and 0.88 g. of p-dimethylaminoethylamine in 250 ml. of absolute ethanol is hydrogenated at atmospheric temperature and pressure. The catalyst is separated and the solution evaporated to a gum. The residue is dissolved in diethyl ether and the solution washed with water, dried and evaporated. The residue is dissolved in 10 ml. of acetone and there is added a solution of 2.2 g. of maleic acid in acetone.
• EXAMPLE 5 340 mg. of the oxime of 3,4,S-triphenyl-cyclohexen-2- one are dissolved in 60 ml. of glacial acetic acid, 2 ml. of concentrated hydrochloric acid are added and hydrogenation is carried out at atmospheric pressure in the presence of 350 mg. of 5% palladium-charcoal. After and evaporation the residue is dissolved in ethanol and treated with saturated ethanolic hydrochloric acid. After evaporating again the residue is triturated with ether to yield crystals of the hydrochloride of 3,4,5-triphenyl-cyclohexylamine melting above 260. This is dissolved in water and ammonia is added to precipitate the free base. Recrystallization from n-hexane yields the 3,4,5-triphenylcyclohexylamine of the formula 35115 melting at 1705-172".
• the starting material can be prepared as follows:
• EXAMPLE 6 480 mg. of 3,4,S-triphenyl-cyclohexanol p-toluene sulfonate and 710 mg. of pyrrolidine are dissolved in 25 ml. of purified dioxane, sealed in a pressure bottle and heated in a steam bath for 6 days. Insoluble salts are separated by filtration and the filtrate is evaporated to dryness. The residue is dissolved in methylene chloride, the solution washed with 5% aqueous sodium carbonate 9 solution, dried and evaporated. Upon recrystallization from n-hexane there is obtained the l-pyrrolidino-3,4,5- triphenyl-cyclohexane of the formula
• the starting material may be prepared as follows:
• EXAMPLE 8 Replacing in Example 1 the 3,5-diphenyl4-(2'-pyridyl)-cyclohexanone by the same amount of 3,5-diphenyl- 4 (3' pyridyl) cyclohexanone or 3,5 diphenyl 4- (4'-pyridyl)-cyclohexanone respectively, and carrying out the procedure in the analogous manner there is obtained the 1 pyrrolidino 3,5 diphenyl 4 (3' pyridyl) cy clohexane or 1 pyrrolidino 3,5 diphenyl 4 (4 pyridyl)cyclohexane respectively.
• EXAMPLE 12 is recrystallized from a small volume of n-hexane; M.P. 129140.
• the starting material used is prepared as follows: 22.1 g. 2-phenacyl-pyridine and 20.1 g. benzalacetone are added in this order to a stirred solution of sodium ethanolate prepared from 3.2 g. sodium and 300 ml. ethanol at room temperature under nitrogen. After stirring for 10 minutes at room temperature and for 30 minutes at 0 the resulting crystals are collected, triturated with hot ethanol, cooled, filtered and the same is repeated with benzene and after recrystallization from ethanol-methylene chloride the 3-hydroxy-3,5-diphenyl-4-(2pyridyl)- cyclohexanone melting at 246248 is obtained.
• EXAMPLE 13 The mixture of 3.27 g. 3,5-diphenyl-4-(2-pyridyl)-cyclohexanone, 5.7 g. anhydrous dimethylamine and 250 ml. absolute ethanol is refluxed for a short time and then hydrogenated at atmospheric temperature and pressure using 0.5 g. of 10% palladium-charcoal. After separation of the catalyst and evaporation the residue is recrystallized from n-hexane to yield a 1:1 mixture of the epimeric lg-dimethylamino-3,5-dipheny1-4-(2-pyridyl) cyclohexane of the formula melting at 80-115". It is separated by thin layer chromatography yielding one epimer melting at 125126 and the other melting at 134136.
• EXAMPLE 14 The mixture of 9.72 g. 3,4,5-triphenyl-2-cyclohexanone, 2.34 g. pyrrolidine, 175 ml. benzene and a trace of ptoluene sulfonic acid is refluxed under nitrogen on a water separator for 6 hours. After evaporation the residue is dissolved in 175 ml. absolute ethanol and hydrogenated in the presence of 10% palladium-charcoal and ml. pyrrolidine for 31 hours under normal conditions. Hereupon the mixture is filtered, the filtrate evaporated, the residue dissolved in diethyl ether and through the solution hydrogen chloride is bubbled.
• EXAMPLE 15 3.99 g. 1-pyrrolidino-3-hydroxy-3,5-diphenyl-4-(2-pyridyl)-cyclohexane in 500 ml. 95% ethanol are hydrogenated in the presence of 2 g. platinum oxide at 50 p.s.i. and 80 for 13 hours. After filtration, evaporation and recrystallization from ethanol the 1-pyrrolidino-3-hydroxy-3,5- dicyclohexyl-4-(2-pyridyl)-cyclohexane of the formula melting at 205-208 is obtained.
• EXAMPLE 16 The mixture of 3.27 g. 3,5-diphenyl-4-(Z-pyridyl)-cyclo- 12 hexanone, 1.76 g. ,B-dimethylamino-ethylamine, 150 ml. absolute ethanol and 0.5 g. 10% palladium-charcoal is hydrogenated at atmospheric temperature and pressure.
• the oil obtained after filtration and evaporation is taken up in petroleum ether and upon scratching one epimer of the so-obtained 1-(2-dimethylamino-ethylamino)-3,5-diphenyl-4-(2-pyridyl)-cyclohexane having the formula CuHs crystallizes and is recrystallized from n-hexane, M.P. 122- 124.
• EXAMPLE 18 The mixture of 3.27 g. 3,5-diphenyl-4-(Z-pyridyD-cyclohexanone, 275 m1. absolute ethanol, 4.3 g. anhydrous ammonia and 0.5 g. 10% palladium-charcoal is hydrogenated at atmospheric temperature and pressure. After filtration and evaporation the obtained crystalline l-amino- 3,5-diphenyl-4-(2-pyridyl)-cyclohexane of the formula CsHs melts upon recrystallization from benzene-cyclohexane at 1575-1585.
• EXAMPLE 19 5.2 g. of the 1g-piperidino-Sfi,5/3-diphenyl-4a-(2-pyridyl)-cyclohexane, obtained according to Example 12, are dissolved in 25 ml. ethanol and the solution chilled and filtered.
• the filtrate is evaporated and the residue recrystallized from n-hexane and acetonitrile to yield the lit-piperidino-3B,5Bdiphenyl-4a-(2-pyridyl)-cycl0hexane of the formula melting at 171-173 (equatorial epimer)
• the hexane mother liquor is evaporated and the residue recrystallized from ethanol and acetonitrile to yield the corresponding lot-epimer (axial) M.P. 148-150".
• EXAMPLE 21 The mixture of 6.52 g. 3,B-4u,5fi-triphenyl-cyclohexanone, 1.75 g. pyrrolidine, a trace of p-toluene sulfonic acid and 100 ml. benzene is refluxed under nitrogen for 12 hours on a Water trap. The residue after evaporation is dissolved in 100 ml. absolute ethanol, containing 1.0 g. 10% palladium-charcoal, and hydrogenated for 2 hours at normal conditions. After filtration and evaporation the residue is dissolved in diethyl ether, the solution filtered, evaporated and the residue dissolved in methylene chloride.
• the solution is washed with several portions of 0.1 N hydrochloric acid, dried and evaporated.
• the residue is triturated with diethyl ether, then suspended in etherwater and mixed with aqueous ammonia.
• the ether layer is separated, dried and evaporated and the residue purified on alumina (neutral, activity 11-111).
• the cyclohexane eluate yields the 1g-pyrrolidino-3fi,4a,5fi-triphenyl-cyclohexane of the formula aHs
• EXAMPLE 23 2.5 g. 3 5,5;9-diphenyl 4oz (-2-pyridyl)-cyclohexanone, 1.52 g. N-methyl-piperazine and a trace of p-toluene sulfonic acid are heated in 70 ml. refluxing toluene for 24 hours, separating the Water formed. The mixture is evaporated in vacuo, the residue suspended in ml. absolute ethanol and hydrogenated in the presence of 0.5 g. 10% palladium-charcoal at normal conditions for 4 /2 hours.
• the residue is triturated with diethylether, suspended in ether-water 2:1, and made alkaline with aqueous ammonia.
• the ether layer is evaporated, the residue dissolved in n-hexane, chromatographed on alumina (neutral, activity II-HI), eluted with n-hexane and recrystallized from acetonitrile yielding the 1m-pyrrolidino-3u-4a,5fi-triphenyl-cyclohexane of the formula melting at 148-151".
• the corresponding lB-epimer is eluted with benzene and melts after recrystallization from n-hexane at 124 126.
• EXAMPLE 25 The mixture of 4.9 g. 35,5;8-diphenyl-4a-(2 pyridyl)- cyclohexanone, 5.74 g. morpholine, one crystal of p-toluene sulfonic acid and 100 ml. benzene is refluxed under nitrogen and on a water trap for 22 hours. It is evaporated, the residue dissolved in 100 ml. absolute ethanol, containing 0.5 g. 10% palladium-charcoal, and hydrogenated -for 2 /2 hours.
• EXAMPLE 26 The mixture of 6.54 g. 3 8,5/3-diphenyl-4a-(2-pyridyl)- cyclohexanone, 28.8 g. pyrrolidine, 0.5 g. 10% palladiumcharcoal and 200 ml. absolute ethanol is hydrogenated for 2 hours. The catalyst is removed, the solvent evaporated, the residue dissolved in hot n-hexane, the solution filtered through charcoal and concentrated. On cooling white crystals separate, representing the la-pyrrolidino- 3 8,5-fi-diphenyl-4 t-(2-pyridyl)cyclohexaine of the formula Cal-I5 melting at 107-110".
• EXAMPLE 28 3.825 g. 1a-pyrrolidino-3fl,5,6-diphenyl-4ot-(2-pyridyl)- cyclohexane are dissolved in 100 ml. glacial acetate acid and 2.0 ml. 30% hydrogen peroxide are added. The solution is kept at 75-80" for 3 hours, mixed with another 1.6 ml. hydrogen peroxide and maintained for 9 hours at this temperature. Hereupon it is concentrated in vacuo to about 15 ml. 100 ml. water are added and then evaporated to dryness. To the residue 5 ml. water and an excess of solid sodium carbonate is added and the whole extracted with methylene chloride. The dried extract is filtered, chilled to 5 and filtered again.
• the white precipitate obtained is washed with cold methylene chloride and dried to yield the bis-N-oxide of 1u-pyrrolidino-35,5;3-diphenyl- 4a-(2-pyridyl)cyclohexane hemihydrate of the formula melting at 176-1765".
• EXAMPLE 29 The mixture of 6.9 g. 3,9,5B-diphenyl-4a-(2-pyridyl)- cyclohexanone, 3 ml. A -pyrroline, 0.01 g. p-toluene sulfonic acid and 125 ml. dry benzene is refluxed under nitrogen and on a water trap for 1 /2 hours and hereupon evaporated. The residue is dissolved in 20 ml. benzene, 0.82 ml. 97% formic acid are added, the solution refluxed for 2 hours under nitrogen and evaporated.
• EXAMPLE 30 is recrystallized from acetonitrile and melts at 162-165.
• the starting material is obtained as follows:
• EXAMPLE 3 1 The mixture of 2.54 g. 3,5-di-(2-furyl)4-(2-pyridyl)- cyclohexanone, 1.16 g. pyrrolidine and 50 ml. benzene is refluxed for 18 hours on a water separator. It is then evaporated in vacuo, the residue dissolved in 40 ml. absolute ethanol and hydrogenated in the presence of 750 mg. 10% palladium-charcoal. After filtration and evaporation the resulting 1-pyrrolidino-3,5-di-(2-furyl) 4-(2-pyridyl) cyclohexane of the formula melts after recrystallization from ethyl acetate at 70-75".
• the starting material is prepared as follows:
• EXAMPLE 32 The mixture of 1.7 g. 3,5-diphenyl-4-(4-pyrimidyl)-cycyohexanone, 1.0 ml. pyrrolidine and 50 ml. benzene is refluxed for 3 hours under nitrogen on a water trap and then evaporated. The residue is dissolved in 100 ml. absolute ethanol and hydrogenated in the presence of 1.0 g. palladium-charcoal at atmospheric pressure. The mixture is filtered, the filtrate evaporated, the residue taken up in diethyl ether and the solution filtered through silica gel and evaporated.
• the starting material is prepared as follows:
• EXAMPLE 33 The mixture of 4.51 g. 3,5-diphenyl-4-(2-quinolyl)-cyclohexanone, 5 ml. pyrrolidine and 150 ml. benzene is refluxed for 16 hours under nitrogen on a water trap. It is then hydrogenated under atmospheric pressure at room temperature in the presence of 1.0 g. platinum oxide and the hydrogenation is stopped after the required volume hydrogen has been consumed. The mixture is filtrated and It shows in the IR. spectrum (Nujol) bands at 1610, 1140, 825, 755 and 695,14.
• the starting material is prepared as follows:
• EXAMPLE 34 The mixture of 3.4 g. 35,5,8-di(4-methoxy-phenyl)-4u- (Z-pyridyl)-cyclohexanone, 2 ml. pyrrolidine and 100 ml. benzene is refluxed on a water trap for 4 hours, then cooled to room temperature and hydrogenated in the presence of 2 g. 10% palladium-charcoal for /2 hour. After filtration and evaporation the residue is dissolved in 10 m1. diethyl ether, 10 ml. pentane are added and the whole is chromatographed on 97.5 alumina (neutral activity I). The column is eluted with 830 ml. diethyl etherpentane 1:1 yielding product A, and 42.0 ml. diethyl ether yielding product B.
• the starting material is prepared as follows:
• the aqueous phase is made basic with sodium hydroxide and then extracted with diethyl ether. The extracts are washed with water and evaporated. The remaining a-(2-pyridyl)-4-methoxy-acetophenone is distilled and the fraction boiling at 162/ 0.05 mm. collected, M.P. 89-91 (petroleum ether). 103.3 g. thereof are added to a solution of 10.6 sodium in 750 ml. anhydrous ethanol, kept under nitrogen, followed by 81 g. 4-methoxy-benzalacetone in 250 ml. ethanol within about /2 hour.
• EXAMPLE 36 The mixture of 6.0 g. 3-hydroxy-3,5fl-di-(4-methoxyphenyl)-4a-(2-pyridyl)-cyclohexanone, 2 ml. pyrrolidine and ml. benzene is refluxed for 12 hours on a water trap. Hereupon it is hydrogenated in the presence of 1.5 g. platinum oxide until one mole equivalent hydrogen is absorbed. After filtration and evaporation the resulting oily 1g-pyrrolidino-3-hydroxy-3,5,B-di (4-rnethoxy-phen- 1y)-4u-(2-pyridyl)-cyclohexane of the formula 00H: is obtained, it shows in the LR. spectrum (Nujol) bands at 1630, 1250, 1050, 840 and 760.41..
• EXAMPLE 37 The mixture of 3 g. 35,5fl-di-(4-chloro-phenyl)-4m-(2- pyridyl)-cycl0hexanone, 2 ml. pyrrolidine and 90 ml. benzene is refluxed for 12 hours on a water trap. Hereupon it is hydrogenated in the presence of 1.5 g. platinum oxide for 35 minutes, wherein one mol equivalent hydrogen is absorbed. After filtration and evaporation the remaining oily lg-pyrrolidino-3B,5,8-di(4-chloro-phenyl)- 4u-(2-pyridyl)-cyclohexane of the formula 11.8 g.
• EXAMPLE 38 The mixture of 3.0 g. 3,8-(4-chloro-phenyl)-4a-(2- pyridyl) 513 (4-methoxy-phenyl) cyclohexanone, 2 ml. pyrrolidine and 90 ml. benzene is refluxed on a water trap for 12 hours and hereupon hydrogenated in the presence of 1.5 g. platinum oxide. After filtration and evaporation the remaining oil 1g-pyrrolidino-3fi-(4-chlorophenyl)- 4oz -(2-pyridyl)- 55 -(4-methoxy-phenyl)-cyclohexane of the formula JWO 3 shows in the LR.
• Example 34 3 hydroxy 3 (4-methoxy-phenyl) 4a (2- pyridyl)-5 3-(4-chloro-phenyl)-cyclohexanone M.P. 234- 236 (diethyl ether-methylene chloride), corresponding A -compound M.P. 110-112" (ethanol) and 3fi-(4-chloro-phenyl)- 4oz -(2-pyridyl)- 5B -(4-methoxy-phenyl)-cyclohexanone M.P. 219220 (diethyl ether).
• EXAMPLE 39 The mixture of 2.22 g. 3fi,5B-di-(3,4,5-trimethoxyphenyl)-4a-(2-pyridyl)-cyclohexanone, 1.84 ml. pyrrolidine and 100 ml. benzene is refluxed for 18 hours on a water trap. Hereupon 0.5 g. platinum oxide are added and the mixture is hydrogenerated at normal conditions until 1 mol equivalent hydrogen is consumed. After filtration and evaporation the remaining l-pyrrolidino-3 ⁇ 3,5fidi (3,4,5-trimethoxy-phenyl) 4a (2-pyridyl) cyclo hexane of the formula OCH3 OCH;
• EXAMPLE 40 To a 14.02% solution and 1.54 g. n-butyl lithium in hexane, diluted with 100 ml. dry diethyl ether and kept at 60 under nitrogen, 4.1 g. 2-bromo-pyridine in 25 ml. diethyl ether are added dropwise with stirring. To the so-obtained stirred solution of 2-pyridyl lithium, 2.0 g. 4-pyrrolidino-cyclohexanone in 25 ml. diethyl ether are added dropwise during 45 minutes at 60 and stirring is continued for 2 hours more. Thereupon 25 ml. ethanol and 25 ml. water are added, the solution warmed up to room temperature and evaporated in vacuo.
• the residue is taken up in 75 ml. methylene chloride and the solution extracted with 10% hydrochloric acid.
• the aqueous layer is made basic with aqueous ammonia, extracted with methylene chloride and the dried extract evaporated.
• the residue is triturated with diethyl ether-petroleum ether, the crystals filtered off and recrystallized from n-hexane to yield the l-pyrrolidino-4-hydroxy-4-(2-pyridyl)-cyclocyclohexene of the formula melting at 1l21l4.
• EXAMPLE 41 The mixture of 3.5 g. 4-(2-pyridyl)-cyclohexanone 1.42 g. pyrrolidine, a trace of p-toluene sulfonic acid and 60 ml. benzene is refluxed under nitrogen for -6 hours on a water trap. It is evaporated in vacuo, the residue dissolved in 150 ml. absolute ethanol and hydrogenated in the presence of 0.6 g. 10% palladium-charcoal at normal conditions. After filtration and evaporation the resulting 1- pyrrolidino-4-(Z-pyridyD-cyclohexane is distilled and the fraction boiling at 147-149/ 0.1 mm. collected; it is identical with that obtained according to Example 40.
• the starting material is prepared as follows:
• EXAMPLE 42 0.44 g. 13-(4 bromo-benzene-sulfonyloxy)-3B,5,8-diphenyl-4a (2-.pyridyl)-cyclohexane are dissolved in 10 ml. dioxane and 0.71 g. pyrrolidine are added. The reaction mixture is heated on a steam bath under nitrogen for 24 hours and evaporated under reduced pressure. The remaining oil is dissolved in diethyl ether, the solution washed with 5% aqueous sodium hydrogencarbonate, dried and evaporated.
• Frictional crystallization of the residue from n-hexane yields, besides some unreacted brosylate, the 1a-pyrrolidino-3 8,5/3-diphenyl-4a-(2-pyridyl)- cyclohexane melting at 107-110"; it is identical with that obtained according to Example 26.
• the starting material is prepared as follows:
• the same equatorial compound melting at 227-228 can be prepared from the starting ketone by reduction with sodium borohydride in dioxane.
• EXAMPLE 43 The mixture of 2.0 g. 3B,5B-diphenyl-4a-(2-pyridyl)- cyclopentanone, 0.71 g. pyrrolidine, 1 crystal of p-toluene sulfonic acid and 50 ml. benzene is refluxed under nitrogen and on a water trap for 16 hours. The residue after evaporation in vacuo is dissolved in 100 ml. absolute ethanol and hydrogenated in the presence of 0.2 g. 10% palladium-charcoal.
• the extracts are dried, evaporated and the residue recrystallized from methanol to yield the l-hydroxy- 313,548-diphenyl 4oz (Z-pyridyl)-cyclopentane-carboxylic acid showing in the LR. spectrum characteristic bands at 1660 and 3500 cmr
• the compounds described hereinbefore may be used as the active ingredient of the following pharmaceutical compositions containing preferably about 25 to 500 mg. per dosage unit. It may be applied once or twice a day.
• the cyclohexane, lactose, 2,500 g. of the corn starch, the sugar and colloidal silica are passed through a 16 mesh screen and mixed for 20 minutes.
• the remaining corn starch is suspended in a cold solution of the color in 1000 ml. water and the suspension added to 4000 ml. boiling water.
• the mixed powders are granulated with the paste obtained using additional water as required.
• the granulate is passed through a 5 mesh screen, placed on trays and dried at 38 until the moisture content is between 2 and 3%.
• the granules are broken on a mill, passed through a 16 mesh screen and treated with the stearic acid and calcium stearate both screened through a 20 mesh screen. After mixing for 20 minutes, the granulate is compressed into tablets using inch dies, standard concave punches, uppers bisected, lowers monogrammed. (The sieve sizes used are mesh per inch.)
• the active ingredient may be replaced by the equivalent amount of other compounds previously described, such as 1a-pyrrolidino-3fl,5B-di-(4- methoxy-phenyl 4- (Z-pyridyl) -cyclohexane dimaleate.
• EXAMPLE 45 The mixture of 3.95 g. 4-cyano-3,5-diphenyl-4-(2-pyridyl)-cyclohexanone, 17 ml. pyrrolidine, 62 ml. benzene and a trace of p-toluenesulfonic acid is refluxed in a nitrogen atmosphere on a water trap for 6 hours. It is then evaporated, the crystalline residue suspended in 250 ml. absolute ethanol and hydrogenated in the presence of 0.5 g. 10% palladium-charcoal.
• the catalyst is removed by filtration and the filtrate evaporated to a crystalline solid, which is recrystallized from chloroform-n-hexane to yield the 15 pyrrolidino 4 cyano 3,5 diphenyl 4-(2-pyridyl)- cyclohexane of the formula melting at 215216.
• the l-pyrrolidino-4-cyano- 3,4,S-triphenyl-cyclohexane melting at 182 can be prepared by selecting the equivalent amount of the corresponding starting material.
• the former starting material is prepared as follows: 9.5 g. dibenzalacetone and 4.8 g. 2-pyridylacetonitrile are added to a stirred sodium methoxide solution prepared from 0.15 g. sodium and 50 ml. anhydrous methanol. An exothermic reaction takes place whereby white crystals are formed. They are filtered ofl, washed twice with methanol and dried, to yield the 4-cyano-3,5-diphenvl-4-(2- pyridyl)-cyclohexanone melting at 176-178.
• EXAMPLE 46 The mixture of 600 mg. 3 5,5/3-diphenyl-4a-(2-pyridy1)- cyclooctanone, 300 mg. pyrrolidine, 50 ml. benzene and one crystal of p-toluenesulfonic acid is refluxed in an atmosphere of nitrogen, on a water trap for 10 hours. The reaction mixture is evaporated to a yellow froth which is dissolved in 50 ml. ethanol and hydrogenated in the presence of mg. 10% palladium-charcoal at atmospheric pressure for 10 hours. The catalyst is removed and the filtrate evaporated to a yellow gum which crystallizes in n-hexane.
• the I.R.-spectrum shows a carbonyl absorption at 1715 cm.” and an olefin absorption at 1670 cmr it represents the 1-pyrr0lidino-3,8,5,8-dipheny1-4a-(2-pyridyl)-8- carbethoxy-6,8-cyclooctadiene.
• the solution is washed with 5% sodium 27 bicarbonate solution, water and brine, dried and evaporated to a yellow gum which shows an U.V.-absorption at 330 and 262 m with shoulders at 282 and 269 my and minima at 313 and 245 m (a methanol solution thereof gives a red color with ferric chloride solution) and represents the 3,B,5,8-diphenyl-4a-(2-pyridyl)- 8-carbethoxy-cyclooct-7-enone.
• the residue is chromatographed of alumina and eluted with benzene-chloroform-ethyl-acetate (50:75:50) to yield the lg-pyrrolidino- 3,4-dipheny1-5-(4-pyridyl)-cyclohexane of the formula CGHE showing in the I.R.spectrum bands at 1135, 1380, 1415, 1460, 1495 and 1600 cmf
• the starting material is obtained as follows: 1.0 g. sodium is reacted with 80 ml. ethanol and to the solution, kept under nitrogen, 9.0 g. desoxybenzoin are added while heating the mixture on a warm water bath until dissolution is finished. Hereupon 6.74 g.
• EXAMPLE 48 The mixture of 5.0 g. 3/3-(2-pyridyl)-4oz,5-diphenylcyclohexene-S-one, 3.3 ml. pyrrolidine, 150 ml. benzene and 50 ml. p-toluene sulfonic acid is refluxed for 24 hours on a water trap. Hereupon the mixture is washed with aqueous sodium bicarbonate, dried and evaporated in vacuo. The residue is dissolved in 25 ml. diethyl ether, to the solution 25 ml. petroleum ether are added and upon standing yellow crystals separate representing the 1- 28 pyrrolidino-3fl-(2-pyridyl)-4a,S-diphenyl-cyclohexa 1,5- diene melting at 140-144".
• the starting material is prepared as follows: The mixture of 9.85 ml. 2-pyridy1 aldehyde and 13.6 ml. ethyl acetoacetate is chilled to 0 and 9 drops of diethylamine are added. The mixture is allowed to stand for 6 days at 5 duringwhich time it becomes a dark green and viscous mixture. The crystalline cake formed is filtered off and the crystals triturated twice with 25 ml. of water. Hereupon they are dissolved in methylene chloride, the solution is passed through a column of silica gel and the eluate is evaporated. The residue is taken up in 50 ml. methylene chloride and 50 ml. cyclohexane and the solution is concentrated to about 30 ml. to yield the ethyl a- (2-pyridyl) methylidene-acetoacetate melting at 118- 122.
• EXAMPLE 49 The mixture of 3.37 g. 3B-phenyl-4a,5-di(2-pyridyl)- cyclohexene-S-one, 3.5 ml. pyrrolidine, ml. dry benzene and 1 mg. p-toluene sulfonic acid is refluxed for 16 hours on a water trap. Hereupon 1.0 g. 10% palladiumcharcoal is added and the mixture is hydrogenated at room temperature and atmospheric presssure until the theoretical amount of hydrogen is absorbed. The mixture is filtered, the filtrate Washed with aqueous ammonia, the organic layer dried, filtered and evaporated under reduced pressure.
• the starting material is prepared analogous to the method shown in Example 48.
• EXAMPLE 50 The solution of 3.96 g. citric acid monohydrate in 30 ml. 95% ethanol is added to the solution of 7.20 g. locpyrrolidino 35,55 diphenyl-4a-(2-pyridyl)-cyclohexane in 30 ml. of the same solvent. The mixture is warmed on the steam bath to dissolve base which initially precipitates; it is then cooled and seeded with crystalline citrate. After about two hours some crystals separate, but stirring and scratching are necessary to obtain a reasonable quantity. After chilling, a first crop M.P. 185-186, is obtained. Two further crops with lower melting points are obtained by successive concentration of the mother liquors. The combined material is recrystallized by dissolution in 65 ml.
• benzene is refluxed in a nitrogen atmosphere for 2 hours under a water trap, then for an additional hour under a Soxhlet apparatus containing potassium hydroxide pellets. After evaporation of the solvent the residue is dissolved in 75 m1. anhydrous ethanol, 0.25 g. of palladium charcoal are added and hydrogenation is carried out at atmospheric pressure. After separation of the catalyst and evaporation of the solvent the residual syrup is taken up in ml. low-boiling petroleum ether.
• the yellow solution deposits the 1,3 pyrrolidino 3,53,5[3 diphenyl-4fi-(2-pyridyl)-cyclohexane of the formula CeHa T -QQ melting at 1335-1345".
• the starting material is prepared as follows:
• 35 g. of the 3,5-diphenyl 4-(2-pyridyl)-cyclohexanone melting at 240 and obtained according to Example 1, are dissolved in 500 ml. benzene and chromatographed on 500 g. alumina (neutral, activity 11-111).
• the first benzene eluate yields pure 3,8,5B-diphenyl-4;3(2-pyridyl)- cyclohexanone, which melts after recrystallization from cyclohexane at 157l58.
• the following eluate is a mixture (A) of said compound together with its 4aand 5aepimers.
• the mixture (A) is recrystallized from cyclohexanebenzene (5:1) to yield the 3,8,5fl-diphenyl-4a-(2-pyridyl)- cyclohexanone melting after recrystallization from methylene chloride-ethylacetate at 240242.
• the mother liquors are evaporated and the residue crystallized from diethyl ether to yield the 3fi,5a-diphenyl-4fi-(2-pyridyl)- cyclohexanone melting at 139.5140.5 after recrystallizations from methanol and cyclohexane.
• EXAMPLE 52 The reaction of 1.96 g. 3B,5a-diphenyl-45-(2-pyridyl)- cyclohexanone, 1.28 g. pyrrolidine and a trace of p-toluenesulfonic acid in 50 ml. benzene is performed as described in Example 51. The enamine obtained is then hydrogenated requiring, however, 18 hours for completion. After separation of the catalyst and removal of the solvent, the residue is taken up as completely as possible in hot cyclohexane, the solution filtered through charcoal and evaporated.
• the residual gum which appears to be homogeneous by thin-layer chromatography, is finally brought to crystallization by dissolution in a few milliliters of acetone and chilling and scratching.
• the resulting product is recrystallized from n-hexane to yield the 1.f-pyrrolidino-3,8,5a-diphenyl-4B-(2-pyridyl) cyclohexane of the formula melting at 123.5-124.5.
• EXAMPLE 53 The mixture of 36.14 g. 3/3,5B-diphenyl-4a-(2-pyridyl)- cyclohexanone, 23.54 g. pyrrolidine and 350 ml. toluene is refluxed for 4 hours on a water trap and hereupon it is evaporated under reduced pressure and at 6070. The residue is suspended in 500 ml. anhydrous ethanol and hydrogenated at room temperature over 4.2 g. 5% palladium-charcoal. After about 2 /2 hours the theoretical amount of hydrogen has been absorbed, the mixture is filtered and the filtrate evaporated in vacuo. The residue is dissolved in 500 ml.
• the starting material is prepared as follows:
• the slurry of 50.0 g. thereof in 150 ml. 85% phosphoric acid is stirred for 24 hours at 20i2 during which time solution occurs.
• the viscous solution is slowly poured onto a mixture of 300 g. ice, 100 ml. concentrated aqueous ammonia and 150 ml. methylene chloride during about one hour. Hereupon 200 m1.
• ammonia are added with cooling to raise the pH to 6.0 to 6.4.
• the organic layer is separated and the aqueous solution extracted 4 times with 50 ml. methylene chloride each.
• the combined organic solutions are washed with 100 ml. water, dried and concentrated on the steam bath to 250 ml. At this point 250 ml.
• cyclohexane are added and distillation is continued until the volume reaches 250 ml. Another 250 ml. cyclohexane are added, the suspension obtained cooled overnight at 5, hereupon filtered and the residue washed with 50 ml. cold cyclohexane to yield the 3,5B-diphenyl- 4a-(2-pyridyl)-2-cyclohexenone melting after drying at 60/40 mm. Hg at 140142.
• Ethylacetate is added to yield a volume of 250 ml., the mixture is refluxed for 15 minutes, then cooled slowly to room temperature and placed overnight in the refrigerator at 5. The following day the crystals formed are filtered off and washed with 25 ml. cold ethylacetate to yield the 35,5;8-diphenyl-4a-(2pyridyl)-cyclohexanone melting at 241-2455
• EXAMPLE 54 1000 tablets each containing 25 mg. of the active ingredient:
• the lactose and the citrate is passed through a comminuting machine using a screen with 1.2 mm. opening.
• the stearate, starch and silica previously mixed with a small portion of the lactose, are added to the sieved powders, which are mixed at low speed for minutes. They are then granulated with ethanol-water (1:1) until suitable granules are formed.
• the granulate is passed through a comminuting machine (knives forward) using a screen with 4.0 mm. opening.
• the granulate is dried at 49 to a moisture content below 2%, again passed through a comminuting machine (knives forward) using a screen with 1.4 mm. opening and compressed into 150 mg. tablets using 7 standard concave punches.
• the disintegration time of said tablets is less than 30 minutes.
• the starch, lactose, stearate and talc are passed through a screen with 1.2 mm. opening and mixed well,
• the citrate and benzothiadiazine, previously mixed with a portion of lactose and passed through the same screen, are added and the whole is blended for 20 minutes in a low speed mixer.
• the syrup and molten glycol are mixed at 70 and the mixture added to the powders to allow granulate for 30 minutes.
• the granulate is passed through a comminuting machine using a screen With 4.0 mm. opening and dried at room temperature overnight with circulating air.
• the dry granulate is passed through a comminuting machine using a screen with 1.4 mm, opening and compressed into 200 mg. tablets using dies and fiat beveled punches.
• the disintegration time of said tablets is about 30 minutes.
• R stands for a member selected from the group consisting of pyrrolidino, piperidino, morpholino, thiamorpholino, 4-methylpiperazino, dimethy'lamino, 2-dimethylamino-ethylamino, amino, n-propylamino and A pyrrolino, or a therapeutically acceptable acid addition salt thereof.

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• 1965
  • 1965-10-18 GB GB43974/65A patent/GB1102428A/en not_active Expired
  • 1965-10-21 FR FR35785A patent/FR1473003A/fr not_active Expired
  • 1965-10-25 AT AT963965A patent/AT263009B/de active
  • 1965-10-25 BE BE671369A patent/BE671369A/xx unknown
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• 1966
  • 1966-01-20 FR FR46585A patent/FR6405M/fr not_active Expired
  • 1966-01-20 FR FR46586A patent/FR5024M/fr not_active Expired
  • 1966-05-11 US US549180A patent/US3455944A/en not_active Expired - Lifetime

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