US3439523A - Hemostatic clip constructions - Google Patents

Hemostatic clip constructions Download PDF

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US3439523A
US3439523A US3439523DA US3439523A US 3439523 A US3439523 A US 3439523A US 3439523D A US3439523D A US 3439523DA US 3439523 A US3439523 A US 3439523A
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clip
applicator
portions
portion
hemostatic
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Ernest C Wood
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RENE G LE VAUX
ERNEST C WOOD
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RENE G LE VAUX
ERNEST C WOOD
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/122Clamps or clips, e.g. for the umbilical cord

Description

April 22, 1969 E. c. WOOD HEMOSTATIC CLIP CONSTRUCTIONS Sheet Original Filed March 30, 1964 Iliili IN VENTOR Ernesz C. Wood y April 22, 1969 3, 000 3,439,523

HEMOSTATIC CLIP CONSTRUCTIONS Original Filed March so, 1964 Sheet 2 of 2 INVENTOE Ernest C. Wood azzys United States Patent 3,439,523 HEMOSTATIC CLIP CONSTRUCTIONS Ernest C. Wood, Los Angeles, Calif., assignor of onethird each to Peter B. Samuels and Rene G. Le Vaux Original application Mar. 30, 1964, Ser. No. 355,810, now Patent No. 3,326,216, dated June 20, 1967. Divided and this application May 8, 1967, Ser. No. 649,391

Int. Cl. BZld 9/08 US. Cl. 72410 7 Claims ABSTRACT OF THE DISCLOSURE This disclosure is of a hemostatic clip applicator of plier type configuration wherein the jaw portions have workpiece receiving faces for receiving hemostatic clips having parallel arm portions interconnected at one end thereof.

This is a division of my copending application Ser. No. 355,810, filed Mar. 30, 1964, and now Patent No. 3,326,216, issued June 20, 1967, and entitled Hemostatic Clip Constructions.

This invention relates to mechanisms useful in the strangulation of tubular members. Specifically, it is directed toward devices including hemostatic clips and applicator structures useful in the strangulation of blood vessels and other fluid ducts in the human body.

The particular application of this invention to the strangulation of blood vessels will serve as an illustration of the inventive concepts enclosed herein. It will be appreciated, however, that the mechanisms embodying the concepts of this invention can be adapted for the closing of other tubular structures at intermediate points as well as near their open ends.

In the course of a surgical operation, a surgeon must often sever one or more blood vessels. It is desirable to provide means for closing the ends of the severed vessels, at least until the end of the operation, to stop bleeding that could interfere with the performance of the operation as well as present unnecessary risks to the patient.

Conventional means for closure consist of ligatures or the like tied about the individual vessels at the desired point of strangulation. The customary technique provides for the separate clamping of each vessel after the incision has been made. After clamping the vessels, a ligature is secured about each vessel providing closure and permitting the removal of the clamps. In some instances a great number of vessels must be severed after requiring one or more hours for proper closure at which point the operation may proceed. It will be apparent that an improved technique for closure will not only obviate the excessive expenditures of time by the surgeon and his assistants under conventional practice but also the dangers to the patient inherent in any delay.

It is an object of this invention to provide mechanisms for use in the strangulation of blood vessels whereby the time required for closure is materially reduced and whereby bleeding can be terminated without the use of the excessive combination of clamping and tying operations.

It is a more particular object of this invention to provide improved mechanisms for the strangulation of blood vessels. and the like whereby the blood vessels may be sealed'off in a highly efficient manner to prevent bleeding during an operation and whereby the operation can proceed with a minimum loss of time as well as blood thereby to maintain conditions most favorable to the patient.

It is a specific object of this invention to provide an improved design for a hemostatic clip, which is adapted to meet the foregoing objects and an applicator struc- 3,439,523 Patented Apr. 22, 1969 ture for the insertion of the aforementioned clip, both to be used in conjunction with a holding means that will facilitate their rapid use to accomplish the aforementioned objects.

These and other obj ects of this invention will hereinafter appear and for purposes of illustration, but not of limitation, specific embodiments of the invention are shown in the accompanying drawings, in which:

FIG. 1 is a plan view of the hemostatic clip applicator structure;

FIG. 2 is an enlarged sectional elevational view of the jaws of the applicator structure;

FIG. 3 is an enlarged top view of one jaw of the applicator, taken about line 3-3 of FIG. 2;

FIG. 4 is an enlarged cross-sectional view of the jaws taken about line 4-4 of FIG. 2;

'FIG. 5 is a view of the applicator along lines 55 of FIG. 1;

FIG. 6 is an elevational view of the applicator;

FIG. 7 is a view of the applicator taken about line 7-7 of FIG. 1;

FIG. 8 is a front elevational view of a magazine construction adapted to hold a plurality of the clips of this invention;

FIG. 9 is an end elevational view of the holding means suitable for hemostatic clips made in accordance with this invention shown in FIG. 8;

FIG. 10 is a view of the holding means taken about line 10-40 of FIG. 8;

FIG. 11 is a sectional elevational view showing the spatial relation of the clip and magazine;

FIG. 12 comprises an enlarged cross-sectional view illustrating the relative positions of clip, applicator and magazine during loading of the applicator with a clip from the magazine;

FIG. 13 is an enlarged sectional view illustrating the manner in which the jaw portions of the applicator provide for closing the clip;

FIG. 14 is a perspective view of a hemostatic clip constrnction designed in accordance with the concepts of this invention;

FIG. 15 is an elevational view of the clip shown in FIG. 14;

FIG. 16 is a view of the clip taken about line 1616 of FIG. 15.

FIG. 17 is a cross-sectional view of the clip taken about line 1717 of FIG. 15.

FIG. 18 is a perspective view of a blood vessel with a clip clamped thereon; and

FIG. 19 illustrates the strangulation of a blood vessel effected by having a clip clamped thereon.

The hemostatic clip of this invention is adapted to be formed from a strip of deformable nontoxic material whereby it can be safely used in an operation. The clip to be fully described hereinafter defines a pair of arm portions with interfaces in opposed relationship. These interfaces, when clamped by means to be described, engage the outer surface of a blood vessel to effect the strangulation desired. The applicator of this invention includes jaw portions with defining means for receiving the outer faces of the arm portion of the clip. When so received the clip will be firmly held and there will be little tendency for the clip to be dislodged therefrom before being clamped to a blood vessel.

In order to further increase the efiiciency of this invention, a suitable magazine or holding means is provided for mounting a plurality of clips in position to be loaded between the jaws of the applicator for use. The holding means and associated clips can be sterilized and packaged whereby they can be stored indefinitely and will be ready for use at any time. The slots defined in the holding means are dimensioned to receive therein the end portion of the jaws of the applicator means, to permit the jaws to grasp the clip contained therein and extract it from the holding means thereby eliminating the necessity of handling the clip at any time between sterilization and use in the strangulation of a blood vessel.

The accompanying drawings illustrate the structures that embody the concepts of this invention. As illustrated in FIGS. 14 through 17, the hemostatic clip of this invention comprises an elongate strip 25 of deformable material having its end portions arranged in arms 28 in spaced apart parallel relation with the facing inner surfaces of the arms being formed intermediate their lateral edges with a valley or recessed portion 26 extending lengthwise through at least the end portion of the arms and preferably through the entire length thereof.

In the preferred practice, as illustrated, the clip is formed with but a single recessed portion which extends continuously through the central portion of the strip but it will be understood that the inner face of the strip may be formed with more than one such recessed portion in side by side parallel relation. The ridges 24 formed alongside the recessed portion are preferably formed to curvilinear shape and the inner surfaces are preferably, but not necessarily, formed with longitudinally spaced apart, crosswise extending serrations 29 which extend continuously crosswise of the strip from edge to edge.

The strip is formed of non-toxic material, such as stainless steel, plastics and like materials, which are capable of being deformed and which retain the amount of deformation for fixedly clamping the blood vessels therebetween.

In the illustrated modification, the bail portion 30 of the strip intermediate the spaced arms 28 is bent to substantially V-shape but it will be apparent that the portion intermediate the arms may be formed to other contours, such as U-shape, rounded shape, or other polygonal shape.

The depth and width of the recess 26 is not sufiicient to noticeably weaken the clip, yet adequate to leave ridges 24 that will impress a circumferential band of compression about the blood vessel whereon the clip is attached.

The crosswise extending serrations are dimensioned to have a depth and width substantially equal to the depth and width of the recess 26, and spaced to permit at least one and preferably more than one such serration to be in contact with the surface of the blood vessel upon which the clip is attached, yet not so close as to permit the distance between the center lines of the serrations to be less than twice the width of recess 26.

FIGS. 1 through 6 illustrate an applicator 10 and details of various portions thereof. The applicator structure comprises two pivotally joined elongate members 11 and 11', each providing a cooperating jaw member 13 on one side of the pivot 12, and cooperating handle portions 11 on the other side of the pivot. Means are provided between the handle portions resiliently to urge the handle portions in the direction away from each other and correspondingly to urge the jaw portions 19 in the direction away from each other but between certain limits, as will hereinafter be defined. For these purposes, there is provided a leaf spring 15 which is formed 15 intermediate its ends to offset the end portions 15 and 15 in normal position, fastened to one handle portion 11 at 16 and slidably connected to the other handle portion.

As best shown in FIG. 5, the movable end 23 of the curvilinear leaf spring 15 defines a slot 22 which is adapted to receive a hook 17 fixed to the handle portion 11. It will be apparent that pressure exerted in the finger holes 18 directed to bring the handles together will cause the movable end portion of the spring 15 to slide relative to its associated handle portion. Similarly, removal of the pressure from the finger holes will permit the spring 15 to urge apart the handle portions and their associated jaw portions, the movable end of the spring sliding relative to its associated handle portion until the end of the slot 22 engages the hook 17 as shown in FIG. 5, thereby limiting the separation of the handle portion 11 and hence the separation of the jaws 13.

Further limiting the separation of the jaws and associated handle portions is the interaction of pin 37, shown in FIG. 1, firmly secured to one of the elongate members 11 or 11 and the edges of hole 38 in the other elongate member through which the pin 37 passes. Both the pin and the hole are preferably located on the handle side of the pivot 12 in a position close to the pivot on portions of the elongate members having mutually sliding interfaces. The hole and pin are dimensioned to permit the pin to move freely in the hole, its motion defining an arc about pivot 12, the hole dimensioned as to limit the separation of the handle portion 11 to that separation to which the handles are limited by the hook 17 engaging the end of the slot 22.

FIG. 3 provides an illustration of the preferred construction of the jaws of the applicator. Each jaw defines a body portion 30 and a lip portion 19 with said lip being angularly offset from the body portion. The contact surfaces of each lip portion is in a coplanar relationship to the surface of the body portion of its associated jaw, the lip and body of each jaw being formed with a blind groove 20 extending continuously throughout the length of the body portion and terminating just short of the end of the jaw thereby to form a ridge 21 on the outer end of the lip portion 19. In the preferred practice, it is desirable to have the recessed portions located centrally along the inner face of the jaw members and to extend continuously about the bend and to terminate in the body portions as illustrated in FIG. 3. The ridge 21 is formed to provide an abrupt abutment at the end of the recessed groove. The straight portion of the blind groove within the lip portion of the jaw is dimensioned to have a length slightly greater than the length of a closed hemostatic clip, a width dimensioned comfortably to receive said clip, and a depth sufiicient to provide a firm hold thereon. As will hereinafter appear, the said ridges and grooves provide for the extracting of the clip 25 from a clip magazine as well as the firm gripping of the clips when held by the jaws.

FIG. 8 illustrates a magazine designed to hold a plurality of clips and FIGS. 9 and 10 the internal features thereof.

As illustrated in the drawings, the clip holder 31 comprises a rigid body in the form of a substantially rectangular block 40 having a recessed portion across the top and down the sides with the recessed portion 32 across the top being formed of V-shaped or other shape corresponding to the bail of the clip and dimensioned to have a length corresponding to the length of the clip and a width slightly greater than the width of the clip. The recessed portion 34, which extend downwardly along the sides of the body from the opposite end of the top recess, are dimensioned to have a width slightly greater than the width of the clip and the jaw portions of the applicator with the bail seated firmly on the saddle portion 32 of the recess and with the arms extending downwardly in the recessed portion 34 with the ends of the clip terminating short of the ends of the recessed portions by an amount which corresponds to the spaced relation between the end of the recessed portion 20 and the end of the jaw portion or slightly greater.

In the use of this invention for the strangulation of blood vessels as shown in FIG. 18, the hook 17 on the handle portion 11 of the applicator is normally positioned relative to the extreme end of the slot 22 in leaf spring 15 as to limit the separation of the lip portions 19 of the jaws 13 to slightly less than the spread of the outer faces of the parallel arm portions 28 of clip 25. It will be appreci ated that on inserting the applicator lips 19 into the defined slot 32 in the clip holder 31 to engage the clip 25, the ridges 21 on the ends of the lips may not easily pass over outer faces of the parallel arm portions 28. Rather, it is necessary to forcefully push the lips 19 into the holder thereby causing a sufiicient separation of the lips to permit the ridges 21 to slide along the parallel arms of the clip."As illustrated in FIG. 12, after sliding the entire length of the arm portions of the clip, the ridges 21, it will be appreciated, snap into the gap 35 resulting from the proper dimensioning of the clip relative to the depth of the recess 32. Moreover, it will be noted that the width of the grooves in the applicator lips are dimensioned approximately equal to the thickness of the clips 25. These two features in combination permit the clip to be received in 'fitting relation within the recessed portion 20. As the jaws of the applicator are withdrawn upwardly from the holder, the clip will tend to remain in the holder until the-abutment 21, formed at the end of the slot, comes into contact with the ends of the clip arms, preferably to position the clip in the jaw members. Continued withdrawal of the applicator jaws will effect displacement of the clip from the holder with the clip properly positioned between the jaw members. The clip will be firmly held thereby, with little tendency for the clip to fall away from the lips and, in this connection, there is no necessity for pressing the jaws together tohold the clips.

The open ends of a clip can be placed on opposite sides of the severed end of a blood vessel and, when pressure is applied through the finger holes 18 and handles 11 of the applicator to urge the jaw members in the direction towards each other, the clip held by the jaws will be clamped as shown in FIG. 13. The interfaces on the ends of the clip arms being the first portions to come in contact, the remainder of the interfaces encircling the blood vessel and pressing together, strangulating the vessel as shown in FIG. 18.

The clips are designed to tightly seal the blood vessel when clamped thereon and, therefore, the use of ligatures in an operation can be greatly diminished. As illustrated in FIG. 19, the ridges of opposed interfaces of the clip engage the surface of the blood vessel at multiple locations 24 whereby more than one tight seal is formed. The advantage of several separate sealing rings in a given length of blood vessel over one single seal is that the clamping force exerted by the clip is concentrated in the circumferental compression band impressed by the ridges on the clips interfaces rather than distributed over the enclosed length of the vessel clamped. To adequately seal the vessel less clamping pressure need be applied than is necessary with the clip with small interfaces. Such reduces the danger of crushing the vessel walls. The multiple crosswise serrations on the clip interfaces insure a firm hold on the blood vessel even with the light clamping pressure necessary to effect strangulation thereby preventing bleeding and providing an additional safety feature insuring that if the clamping pressure used to close the clip is excessive, part of the vessel upon which the clamp is fixed will remain uncrushed.

The design of the clip construction 25, which represents the preferred design, is particularly important. Thus,.the provisions of the parallel portions 28 serves to insure a firm gripping action by the applicator. These straight sections of the clip are readily seated in the grooves 20 in the lips 19, the ridges 21 preventing the clip from sliding from the groove.

The clip of this invention is preferably formed of surgical metals which are non-toxic and where therefore can be tolerated within the body for indefinite periods of time. Representatives of such metals are stainless steel, platinum and tantalum. It is also contemplated that the clips be formed of less expensive non-toxic, non-metallic materials such as plastic, or materials which are slowly absorbable in body fiuids, such as collagen, gelatin, albumin, dried blood, synthetic materials, and the like.

It will be understood that various changes can be made in the above described hemostatic clip and applicator constructions which provide the characteristics of this invention without departing from thes pirit thereof, particularly as defined in the following claims.

I claim:

1. A hemostatic clip applicator for use with hemostatic clips having interconnected parallel arm portions, said applicator structure comprising two members pivotally interconnected intermediate their ends to provide jaw portions on one side of the pivot and handle portions on the other, said jaw portions consisting of a body portion and a lip portion, opposed recessed blind channels in said lip priion dimensioned to receive and hold the parallel arm portions of the clips, said channels terminating short of the ends of the lip portions to receive the clip arms in seated relation between the lip portions, whereby upon displacement of said jaw portions in the direction towards each other said members operate to effect the displacement of the clip arms in the direction towards each other into clamping position.

2. A hemostatic clip applicator constructed in accordance with claim 1, the lips therein dimensioned to have a length slightly greater than the length of the straight portion of the blind channel formed therein, the straight portion of the blind channel dimensioned to have a length slightly greater than the length of a closed hemostatic clip.

3. A hemostatic clip applicator constructed in accordance with claim 1 in which the width of said lip is greater than the width of the blind channel formed therein, the width of said channel dimensioned to comportably receive the outer face of one of the opposed parallel arm portions of the hemostatic clip.

4. A hemostatic clip applicator constructed in accordance with claim 1 in which the abutment between the extreme ends of each of the said lip portions and the ends of the blind channels formed therein is dimensioned to have a thickness corresponding to somewhat less than the distance between the extreme ends of the opposed parallel arms of a clip and the end of the recessed portion of a clip holder into which a clip is inserted.

5. An applicator construction in accordance with claim 1 including resilient means associated with said handle portions for normally urging said jaws into a spacedapart relationship, and a stop means associated with said resilient means constructed to limit the spaced relationship of the jaws to a distance measured from the beds of the opposed blind channels not significantly greater than the normal spread between the arms of said clips.

6. An applicator construction in accordance with claim 1 including a stop means constructed to limit the spaced relation of the handles and associated jaw portions comprising a pin firmly fastened to one member of the applicator at a point close to the pivot and passing through an oversize hole in the other member.

7. A hemostatic clip applicator for use with a hemostatic clip of the type having parallel arm portions interconnected at one end thereof, said applicator structure comprising two members pivotally interconnected intermediate their ends to provide jaw portions on one side of the pivot and handle portions on the other, said jaw portions having receiving means adapted to receive and hold the arm portions of said clip, the configuration of said receiving means in relation to the placement of said pivot being such that upon displacement of said jaw portions in the direction toward each other the arm portions of said clip first come together at their open ends forming an elliptical opening therebetween, whereby upon continuous displacement together of said jaws said clip substantially flattens to complete its clamping function.

References Cited UNITED STATES PATENTS 3,006,344 10/1961 Vogelfanger 72410 3,082,426 3/1963 Miles 72-410 RONALD D. CREPE, Primary Examiner.

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Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242902A (en) * 1978-05-11 1981-01-06 United States Surgical Corporation Surgical clip applicator
DE3106851A1 (en) * 1980-02-25 1982-02-25 Ethicon Inc hemostatic clip
DE3311830A1 (en) * 1982-04-05 1983-10-20 Senco Products clip-instrument surgical and klammerntraeger
EP0092300A1 (en) * 1982-02-05 1983-10-26 Ethicon Inc. Tip configuration for a ligating clip applier
US4570633A (en) * 1981-09-28 1986-02-18 Ethicon, Inc. Surgical clip applier instrument adapter jaws
US4616651A (en) * 1985-04-15 1986-10-14 Ethicon, Inc. Surgical clip applier instrument adapter jaws
EP0201344A2 (en) 1985-05-10 1986-11-12 Ethicon Inc. Ligating clip and clip applier
US4696396A (en) * 1985-12-19 1987-09-29 Samuels Peter B Hemostatic clip cartridge
US5147356A (en) * 1991-04-16 1992-09-15 Microsurge, Inc. Surgical instrument
US5269792A (en) * 1992-05-26 1993-12-14 Origin Medsystems, Inc. Surgical clip
US5279416A (en) * 1992-06-05 1994-01-18 Edward Weck Incorporated Ligating device cartridge with separable retainer
US5431669A (en) * 1993-07-16 1995-07-11 Origin Medsystems, Inc. Surgical clip applier with distal hook
US6290575B1 (en) 1999-03-01 2001-09-18 John I. Shipp Surgical ligation clip with increased ligating force
US6350269B1 (en) 1999-03-01 2002-02-26 Apollo Camera, L.L.C. Ligation clip and clip applier
US20040044363A1 (en) * 2002-08-27 2004-03-04 Fowler David N. Apparatus and method for removing a clip
US20040040875A1 (en) * 2002-08-27 2004-03-04 Gallagher Richard J. Cartridge for holding asymmetric surgical clips and method for loading surgical clips into a clip applier
US20040044352A1 (en) * 2002-08-27 2004-03-04 Fowler David N. Fingertip-actuated surgical clip applier and related methods
US20040059359A1 (en) * 2002-09-20 2004-03-25 Wilson Donald F. Ligating clip with integral penetrating hook
US20040097971A1 (en) * 2002-11-19 2004-05-20 Hughett J. David Automated-feed surgical clip applier and related methods
US20040097970A1 (en) * 2002-11-19 2004-05-20 Hughett J. David Automated-feed surgical clip applier and related methods
US20040097972A1 (en) * 1993-08-25 2004-05-20 Surgicon, Inc. Surgical ligation clip and method for use thereof
US20050113847A1 (en) * 1999-01-25 2005-05-26 Applied Medical Resources Corporation Surgical instrument with improved handle assembly
US20050119677A1 (en) * 2003-06-09 2005-06-02 Shipp John I. Ligation clip applier
US20050149063A1 (en) * 2003-10-21 2005-07-07 Young Wayne P. Clip applier tool having a discharge configuration and method for use thereof
US20060124485A1 (en) * 2004-12-10 2006-06-15 Kennedy Daniel L Enhanced visibility cartridge with improved retainer
US20060129168A1 (en) * 2002-11-12 2006-06-15 Surgicon, Inc. Surgical ligation clip
US7485092B1 (en) 1998-08-12 2009-02-03 Maquet Cardiovascular Llc Vessel harvesting apparatus and method
US7534243B1 (en) 1998-08-12 2009-05-19 Maquet Cardiovascular Llc Dissection and welding of tissue
US7695470B1 (en) 1998-08-12 2010-04-13 Maquet Cardiovascular Llc Integrated vessel ligator and transector
US7938842B1 (en) 1998-08-12 2011-05-10 Maquet Cardiovascular Llc Tissue dissector apparatus
USD667116S1 (en) * 2009-06-04 2012-09-11 Medline Industries, Inc. Hinged medical instrument

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US3006344A (en) * 1959-02-24 1961-10-31 Isaac J Vogelfanger Surgical ligator and cutter
US3082426A (en) * 1960-06-17 1963-03-26 George Oliver Halsted Surgical stapling device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3006344A (en) * 1959-02-24 1961-10-31 Isaac J Vogelfanger Surgical ligator and cutter
US3082426A (en) * 1960-06-17 1963-03-26 George Oliver Halsted Surgical stapling device

Cited By (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242902A (en) * 1978-05-11 1981-01-06 United States Surgical Corporation Surgical clip applicator
DE3106851A1 (en) * 1980-02-25 1982-02-25 Ethicon Inc hemostatic clip
US4570633A (en) * 1981-09-28 1986-02-18 Ethicon, Inc. Surgical clip applier instrument adapter jaws
EP0092300A1 (en) * 1982-02-05 1983-10-26 Ethicon Inc. Tip configuration for a ligating clip applier
DE3311830A1 (en) * 1982-04-05 1983-10-20 Senco Products clip-instrument surgical and klammerntraeger
US4485953A (en) * 1982-04-05 1984-12-04 Senco Products, Inc. Surgical stapling instrument and cartridge therefor
US4616651A (en) * 1985-04-15 1986-10-14 Ethicon, Inc. Surgical clip applier instrument adapter jaws
EP0201344A2 (en) 1985-05-10 1986-11-12 Ethicon Inc. Ligating clip and clip applier
US4696396A (en) * 1985-12-19 1987-09-29 Samuels Peter B Hemostatic clip cartridge
US5147356A (en) * 1991-04-16 1992-09-15 Microsurge, Inc. Surgical instrument
US5269792A (en) * 1992-05-26 1993-12-14 Origin Medsystems, Inc. Surgical clip
US5279416A (en) * 1992-06-05 1994-01-18 Edward Weck Incorporated Ligating device cartridge with separable retainer
WO1994001044A1 (en) * 1992-07-02 1994-01-20 Origin Medsystems, Inc. Surgical clip
US5431669A (en) * 1993-07-16 1995-07-11 Origin Medsystems, Inc. Surgical clip applier with distal hook
US7582095B2 (en) 1993-08-25 2009-09-01 Apollo Camera, L.L.C. Surgical ligation clip and method for use thereof
US20040097972A1 (en) * 1993-08-25 2004-05-20 Surgicon, Inc. Surgical ligation clip and method for use thereof
US7938842B1 (en) 1998-08-12 2011-05-10 Maquet Cardiovascular Llc Tissue dissector apparatus
US7534243B1 (en) 1998-08-12 2009-05-19 Maquet Cardiovascular Llc Dissection and welding of tissue
US7485092B1 (en) 1998-08-12 2009-02-03 Maquet Cardiovascular Llc Vessel harvesting apparatus and method
US9730782B2 (en) 1998-08-12 2017-08-15 Maquet Cardiovascular Llc Vessel harvester
US8460331B2 (en) 1998-08-12 2013-06-11 Maquet Cardiovascular, Llc Tissue dissector apparatus and method
US8986335B2 (en) 1998-08-12 2015-03-24 Maquet Cardiovascular Llc Tissue dissector apparatus and method
US20100234843A1 (en) * 1998-08-12 2010-09-16 Maquet Cardiovascular Llc Apparatus and method for integrated vessel ligator and transector
US9700398B2 (en) 1998-08-12 2017-07-11 Maquet Cardiovascular Llc Vessel harvester
US8075559B2 (en) 1998-08-12 2011-12-13 Maquet Cardiovascular, Llc Apparatus and method for integrated vessel ligator and transector
US7695470B1 (en) 1998-08-12 2010-04-13 Maquet Cardiovascular Llc Integrated vessel ligator and transector
US20050113847A1 (en) * 1999-01-25 2005-05-26 Applied Medical Resources Corporation Surgical instrument with improved handle assembly
US7731725B2 (en) * 1999-01-25 2010-06-08 Applied Medical Resources Corporation Surgical instrument with improved handle assembly
US7207997B2 (en) 1999-03-01 2007-04-24 Shipp John I Ligation clip and clip applier
US6652539B2 (en) 1999-03-01 2003-11-25 Surgicon, Inc. Method for applying a ligation clip
US20040106936A1 (en) * 1999-03-01 2004-06-03 Surgicon, Inc. Ligation clip and clip applier
US6290575B1 (en) 1999-03-01 2001-09-18 John I. Shipp Surgical ligation clip with increased ligating force
US6652545B2 (en) 1999-03-01 2003-11-25 Surgicon, Inc. Ligation clip and clip applier
US6350269B1 (en) 1999-03-01 2002-02-26 Apollo Camera, L.L.C. Ligation clip and clip applier
US20070021777A1 (en) * 2002-08-27 2007-01-25 Fowler David N Apparatus and method for removing a clip
US7131977B2 (en) 2002-08-27 2006-11-07 Pilling Weck Incorporated Apparatus and method for removing a clip
US20040040875A1 (en) * 2002-08-27 2004-03-04 Gallagher Richard J. Cartridge for holding asymmetric surgical clips and method for loading surgical clips into a clip applier
US7211091B2 (en) 2002-08-27 2007-05-01 Pilling Weck Incorporated Fingertip-actuated surgical clip applier and related methods
US20040044363A1 (en) * 2002-08-27 2004-03-04 Fowler David N. Apparatus and method for removing a clip
US20040044352A1 (en) * 2002-08-27 2004-03-04 Fowler David N. Fingertip-actuated surgical clip applier and related methods
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US20040059359A1 (en) * 2002-09-20 2004-03-25 Wilson Donald F. Ligating clip with integral penetrating hook
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