US3343540A - Swab-type applicator with impregnated medicament - Google Patents
Swab-type applicator with impregnated medicament Download PDFInfo
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- US3343540A US3343540A US362927A US36292764A US3343540A US 3343540 A US3343540 A US 3343540A US 362927 A US362927 A US 362927A US 36292764 A US36292764 A US 36292764A US 3343540 A US3343540 A US 3343540A
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- wad
- applicator
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- polyethylene glycol
- absorbent material
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
- A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
Definitions
- applicators for surface application of medicaments
- such applicators may comprise an absorbent wad, such as a cotton wad, aifixed to the end of a thin stem, such as a wooden stem, plastic stem or paperboard stem.
- a thin stem such as a wooden stem, plastic stem or paperboard stem.
- a larger absorbent wad such as cotton pad or gauze pad
- a supporting stem such as cotton pad or gauze pad
- a disposable medicative applicator including a wad of absorbent material which is impregnated with a medicinal ingredient carried by a water dispersible low melting point resinous material in dry form.
- the applicator comprises a wad affixed to at least one end of a stern.
- the medicative applicator is made by initially forming a uniform liquid mixture containing the medicinal ingredient, or medicament, and a melt of its resin carrier, impreganting the absorbent wad with said liquid mixture and thereafter cooling and solidifyin said mixture impregnated on said wad.
- the medicant is dispersed in the melted resin, either as a true solution therein, or as a colloidal solution, or as a suspension, depending on the nature and concentration of the medicament and the nature of the resin.
- the liquid mixture is prepared by adding the desired amount of medicament, with stirring, to a batch of melted resin.
- the absorbent wad which is preferably composed of cotton, is dipped into the liquid mixture to thereby impregnate the wad, and is then removed from the mixture bath and allowed to solidify by cooling.
- the water dispersible resinous material is preferably a water soluble material capable of forming a true solution in water, but materials capable of forming stable emulsions, particularly in the presence of a surfactant, may also be used.
- the resulting applicator with its resin coated wad can be labeled with the name of the medicinal ingredient stamped or indicated by other means on the applicator stem.
- the applicators could be placed in boxes which are so labeled.
- This invention is not restricted to the use of any particular water dispersible low melting point resinous material, nor does it relate to medicaments per se.
- a suitable resin is polyethylene glycol.
- Polyethylene glycol is sold commercially as Carbowax (a trademark of Carbide and Carbon Chemicals Company). The polyethylene glycols are available in the variety of grades, are waxy in appearance and texture and have a relatively low melting point.
- Polyethylene glycol 400 melts at about 25% C. while polyethylene glycol 4000 has a melting point of approximately 55 C. Polyethylene glycol 400, which is considerably softer than polyethylene glycol 4000, improves the smoothness and uniformity of the resulting coating, when it is combined with the latter.
- Suitable water dispersible, low melting point resins which could be used in accordance with the invention are the polyoxyalkylene derivatives of lanolins and lanolin alcohols, polyoxyalkylene derivatives of cholesterol, polyoxyalkylene derivatives of sorbitol and lanolin, polyoxyethylene sorbitan tristearate, polyoxyethylene lauryl ether and polyoxyethylene derivatives of sorbitol and beeswax.
- Polyethylene glycol is the preferred water soluble resinous carrier not only because of its low melting point which permits fabrication of the swabs from a melt, but also because of its waxy nature which enables it to act as a lubricant when the applicator is used.
- the wad of the applicator is lightly wetted, as by dipping into a container of water, and the wetted wad is thereafter applied to the body surface desired to be treated.
- the proportions of resin and medicament are obviously dependent upon the nature of the medicament and the amount which is desired at the site of application. Generally at least 40 weight percent of water soluble resin, based on the combined weight of resin and medicament is required to act as a carrier base. Amounts of resin between about 40 percent and about 99.9 percent are suitable and amounts between about 60 percent and about 99 percent are preferred.
- Example IV As an anti-inflammatory agent: Hydrocortisone mg 250 Phenol g 5 Polyethylene glycol 400 g 20 Polyethylene glycol 4000 q.s ml 100
- Example V As a skin antiseptic:
- Polychol 15 (trademark designation for ethoxylated lanolin alcohol having about 15 ethylene oxide units)
- Example VI As a skin antiseptic:
- Hyamine 1622 (trademark designation for diisobutyl phenoxy ethoxy ethyl dimethyl benzyl ammonium chloride) 0.01 Water 5.0 Beeswax -a 50.0 Spermaceti 5.0 Mineral oil 5.0 Polyethylene glycol 4000 5.0
- Other medicinal agents which may be applied to swabs in water dispersible low melting point resins in accordance with this invention include local anesthetics for topical application, such as benzocaine and butacaine; protective materials, such as zinc oxide, titanium dioxide and zirconium oxide; anti-infective or antibacterial agents, such as tetracycline, hexachlorophene, bithionol, phenol, resorcinol and neomycin; anti-histamines, such as chlorpheniramine maleate; keratolytics, such as salicyclic acid; anti-fungal agents, such as salicylic acid, undecylenic acid and zinc undecylenate; astringents, such as zinc oxide and aluminum salts; and surface active agents, such as benzalkonium chloride and sodium lauryl sulfate.
- local anesthetics for topical application such as benzocaine and butacaine
- protective materials such as zinc oxide, titanium dioxide and
- this invention provides greater stability for those medicinal and other topical ingredients which are susceptible to degradation or bacterial in a wet state.
- the topical agents are maintained in accordance with this invention, their resistance to degradation is enhanced.
- this invention permits controlled application of topical agents and provides a prac tical means to avoid the application of excessive amounts of such agents, as might be the tendency with ointments and liquids.
- a medicative applicator which comprises a stem having a wad of absorbent material afiixed to at least one end thereof, said absorbent material being impregnated with a mixture comprising a medicinal ingredient carried by a water dispersible low melting point resinous material.
- a medicative applicator which comprises a t having a wad of cotton aflixed to at least one end thereof, said cotton being impregnated with a mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by a water soluble low melting point resin from about 40 percent to about 99.9 percent.
- a medicative applicator which comprises a stern having a wad of cotton affixed to at least one end thereof, said cotton being impregnated with a mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by polyethylene glycol from about 40 percent to about 99.9 percent.
- a medicative applicator which comprises a stem having a wad of cotton aflixed to at least one end thereof, said cotton being impregnated with a mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by a polyoxyalkylene derivative of lanolin from about 40 percent to about 99.9 percent.
- a medicative applicator which comprises a stern having a stem with a wad of absorbent material aflixed to of, said cotton being impregnated with a mixture comprising, by Weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by a polyoxyalkylene derivative of a lanolin alcohol from about 40 percent to about 99.9 percent.
- the method of preparing a medicative applicator having a stem with a wad of absorbent material afi'ixed to at least one end thereof comprising the steps of forming a uniform liquid mixture comprising a medicinal ingredient and a melted water dispersible resin, applying said uniform liquid mixture to said absorbent material, and solidifying by cooling a resin-medicinal ingredient composition from the mixture which has been applied to said absorbent material.
- the method of preparing a medicative applicator having a stem with a wad of absorbent material aflixed to at least one end thereof comprising the steps of forming a uniform liquid mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to above 60 percent carried by polyethylene glycol from about 40 percent to about 99.9 percent, applying said uniform liquid mixture to said absorbent material, and cooling the mixture which has been applied to said absorbent mate rial to solidify it.
- the method of preparing a medicative applicator having a stem with a Wad of absorbent material afiixed to at least one end thereof comprising the steps of forming a uniform liquid mixture comprising, a medicinal ingredient and a melt of a polyoxyalkylene derivative of lanolin, applying said uniform liquid mixture to said absorbent material and solidifying the mixture which has been applied to said absorbent material.
- the method of preparing a medicative applicator having a stem with a wad of absorbent material affixed to at least one end thereof comprising the steps of forming a uniform liquid mixture comprising, a medicinal ingredient and a melt of a polyoxyalkylene derivative of a lanolin alcohol, applying said uniform liquid mixture to said absorbent material, and solidifying the mixture which has been applied to said absorbent material.
- testing Officer out "having a stem with a to of” and insert instead at least one end thereof of October 1968.
Description
United States Patent Ofiice 3,343,540 Patented Sept. 26, 1967 3,343,540 SWAB-TYPE APPLICATOR WITH IMPREGNATED MEDICAMENT Frederick P. Siege], Chicago, Ill., assignor to Frederick P. Siege], Chicago, Ill., and Howard S. Siege], Skokie, Ill. No Drawing. Filed Apr. 27, 1964, Ser. No. 362,927 9 Claims. (Cl. 128-269) This invention relates to an applicator and particularly, to an applicator for the disposition of a topical agent on a body surface. In an optimum embodiment, the invention relates to a medicative applicator.
The use of applicators for surface application of medicaments is common. In one form, such applicators may comprise an absorbent wad, such as a cotton wad, aifixed to the end of a thin stem, such as a wooden stem, plastic stem or paperboard stem. In the use of such applicators, it is necessary to dip the absorbent wad into a bottle containing a medicative ingredient or to obtain the medicament from another external supply before it can be applied to the desired area.
In another form of applicator, a larger absorbent wad, such as cotton pad or gauze pad, may be used without a supporting stem. Such applicators are held directly in the hand during use in topical application.
The necessity of keeping bottles and tubes containing niedicaments on hand has many disadvantages, the primary one being that of storage difficulties. In small dispensaries, first aid stations and first aid kits in particular, the lack of storage facilities is an acute problem. In hospitals where storage facilities are adequate the necessity of opening bottles and tubes and applying the medicament to the applicator wad is troublesome and may result in spillage and a generally inefficient operation.
Many sanitary problems are incurred in the use of medicament bottles and tubes which have been exposed to opening thereof. As an example, the ointment within a tube can be easily contaminated if the member which received the preceding eliminated ointment contained surface germs.
In the present invention the foregoing difficulties are obviated in that there is provided a disposable medicative applicator including a wad of absorbent material which is impregnated with a medicinal ingredient carried by a water dispersible low melting point resinous material in dry form. In a preferred embodiment the applicator comprises a wad affixed to at least one end of a stern.
In accordance with the invention, the medicative applicator is made by initially forming a uniform liquid mixture containing the medicinal ingredient, or medicament, and a melt of its resin carrier, impreganting the absorbent wad with said liquid mixture and thereafter cooling and solidifyin said mixture impregnated on said wad. The medicant is dispersed in the melted resin, either as a true solution therein, or as a colloidal solution, or as a suspension, depending on the nature and concentration of the medicament and the nature of the resin. Usually the liquid mixture is prepared by adding the desired amount of medicament, with stirring, to a batch of melted resin.
The absorbent wad, which is preferably composed of cotton, is dipped into the liquid mixture to thereby impregnate the wad, and is then removed from the mixture bath and allowed to solidify by cooling.
The water dispersible resinous material is preferably a water soluble material capable of forming a true solution in water, but materials capable of forming stable emulsions, particularly in the presence of a surfactant, may also be used.
The resulting applicator with its resin coated wad can be labeled with the name of the medicinal ingredient stamped or indicated by other means on the applicator stem. Of course, the applicators could be placed in boxes which are so labeled. When it is necessary to apply the particular medication, the wad is dipped into a water supply so that the resin is caused to soften and partially dissolve, and the wad is then applied to the zone requiring medication.
This invention is not restricted to the use of any particular water dispersible low melting point resinous material, nor does it relate to medicaments per se.
Of course it is necessary to use a water soluble, low melting point resin which is non-toxic and a nonirritant. A suitable resin is polyethylene glycol. Polyethylene glycol is sold commercially as Carbowax (a trademark of Carbide and Carbon Chemicals Company). The polyethylene glycols are available in the variety of grades, are waxy in appearance and texture and have a relatively low melting point. Polyethylene glycol 400 melts at about 25% C. while polyethylene glycol 4000 has a melting point of approximately 55 C. Polyethylene glycol 400, which is considerably softer than polyethylene glycol 4000, improves the smoothness and uniformity of the resulting coating, when it is combined with the latter.
Other suitable water dispersible, low melting point resins which could be used in accordance with the invention are the polyoxyalkylene derivatives of lanolins and lanolin alcohols, polyoxyalkylene derivatives of cholesterol, polyoxyalkylene derivatives of sorbitol and lanolin, polyoxyethylene sorbitan tristearate, polyoxyethylene lauryl ether and polyoxyethylene derivatives of sorbitol and beeswax.
Polyethylene glycol is the preferred water soluble resinous carrier not only because of its low melting point which permits fabrication of the swabs from a melt, but also because of its waxy nature which enables it to act as a lubricant when the applicator is used.
In use, the wad of the applicator is lightly wetted, as by dipping into a container of water, and the wetted wad is thereafter applied to the body surface desired to be treated.
The proportions of resin and medicament are obviously dependent upon the nature of the medicament and the amount which is desired at the site of application. Generally at least 40 weight percent of water soluble resin, based on the combined weight of resin and medicament is required to act as a carrier base. Amounts of resin between about 40 percent and about 99.9 percent are suitable and amounts between about 60 percent and about 99 percent are preferred.
Example I For the treatment of acne:
Salicyclic acid g 2 Hexachlorophene g 1 Polyethylene glycol 400 g 20 Polyethylene glycol 4000 q.s ml 100 Example 11 For removal of cerurnen:
Urea peroxide g 6 Polyethylene glycol 400 g 10 Polyethylene glycol 4000 q.s mL- 100 Example 111 As a styptic agent:
Alum g 50 Polyethylene glycol 4000 q.s ml 100 3 Example IV As an anti-inflammatory agent: Hydrocortisone mg 250 Phenol g 5 Polyethylene glycol 400 g 20 Polyethylene glycol 4000 q.s ml 100 Example V As a skin antiseptic:
Grams Benzalkonium chloride 0.01
Polychol 15 (trademark designation for ethoxylated lanolin alcohol having about 15 ethylene oxide units) Light mineral oil 15 Water Example VI As a skin antiseptic:
Grams Resorcinol 1.0 Polyethylene glycol 400 1.0 Polychol 50.0 Polyethylene glycol 4000 48.0 Example VII As a skin antiseptic:
Grams Hyamine 1622 (trademark designation for diisobutyl phenoxy ethoxy ethyl dimethyl benzyl ammonium chloride) 0.01 Water 5.0 Beeswax -a 50.0 Spermaceti 5.0 Mineral oil 5.0 Polyethylene glycol 4000 5.0
Other medicinal agents which may be applied to swabs in water dispersible low melting point resins in accordance with this invention include local anesthetics for topical application, such as benzocaine and butacaine; protective materials, such as zinc oxide, titanium dioxide and zirconium oxide; anti-infective or antibacterial agents, such as tetracycline, hexachlorophene, bithionol, phenol, resorcinol and neomycin; anti-histamines, such as chlorpheniramine maleate; keratolytics, such as salicyclic acid; anti-fungal agents, such as salicylic acid, undecylenic acid and zinc undecylenate; astringents, such as zinc oxide and aluminum salts; and surface active agents, such as benzalkonium chloride and sodium lauryl sulfate.
Those skilled in the art will have no difiiculty in determining suitable proportions of the above agents to be used from the known pharmacological properties of these agents in other media.
In addition to the advantages enumerated above, the use of this invention provides greater stability for those medicinal and other topical ingredients which are susceptible to degradation or bacterial in a wet state. In the solid anhydrous form in which the topical agents are maintained in accordance with this invention, their resistance to degradation is enhanced.
Furthermore, the use of this invention permits controlled application of topical agents and provides a prac tical means to avoid the application of excessive amounts of such agents, as might be the tendency with ointments and liquids.
The invention has been described as applied to preferred embodiments and it will be understood that various substitutions and changes may be efiected without departing from the spirit and scope of the novel concepts and principles of this invention.
I claim:
1. A medicative applicator which comprises a stem having a wad of absorbent material afiixed to at least one end thereof, said absorbent material being impregnated with a mixture comprising a medicinal ingredient carried by a water dispersible low melting point resinous material.
2. A medicative applicator which comprises a t having a wad of cotton aflixed to at least one end thereof, said cotton being impregnated with a mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by a water soluble low melting point resin from about 40 percent to about 99.9 percent.
3. A medicative applicator which comprises a stern having a wad of cotton affixed to at least one end thereof, said cotton being impregnated with a mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by polyethylene glycol from about 40 percent to about 99.9 percent.
4. A medicative applicator which comprises a stem having a wad of cotton aflixed to at least one end thereof, said cotton being impregnated with a mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by a polyoxyalkylene derivative of lanolin from about 40 percent to about 99.9 percent.
5. A medicative applicator which comprises a stern having a stem with a wad of absorbent material aflixed to of, said cotton being impregnated with a mixture comprising, by Weight, a medicinal ingredient from about 0.1 percent to about 60 percent carried by a polyoxyalkylene derivative of a lanolin alcohol from about 40 percent to about 99.9 percent.
6. The method of preparing a medicative applicator having a stem with a wad of absorbent material afi'ixed to at least one end thereof, comprising the steps of forming a uniform liquid mixture comprising a medicinal ingredient and a melted water dispersible resin, applying said uniform liquid mixture to said absorbent material, and solidifying by cooling a resin-medicinal ingredient composition from the mixture which has been applied to said absorbent material.
7. The method of preparing a medicative applicator having a stem with a wad of absorbent material aflixed to at least one end thereof, comprising the steps of forming a uniform liquid mixture comprising, by weight, a medicinal ingredient from about 0.1 percent to above 60 percent carried by polyethylene glycol from about 40 percent to about 99.9 percent, applying said uniform liquid mixture to said absorbent material, and cooling the mixture which has been applied to said absorbent mate rial to solidify it.
8. The method of preparing a medicative applicator having a stem with a Wad of absorbent material afiixed to at least one end thereof, comprising the steps of forming a uniform liquid mixture comprising, a medicinal ingredient and a melt of a polyoxyalkylene derivative of lanolin, applying said uniform liquid mixture to said absorbent material and solidifying the mixture which has been applied to said absorbent material.
9. The method of preparing a medicative applicator having a stem with a wad of absorbent material affixed to at least one end thereof, comprising the steps of forming a uniform liquid mixture comprising, a medicinal ingredient and a melt of a polyoxyalkylene derivative of a lanolin alcohol, applying said uniform liquid mixture to said absorbent material, and solidifying the mixture which has been applied to said absorbent material.
References Cited UNITED STATES PATENTS 2,020,107 11/1935 Cruickshank 128271 2,244,027 6/1941 Smith 128-271 2,467,884 4/ 1949 Elias. 2,579,403 12/1951 SlomowitZ et al. 128269 2,696,456 12/1954 Hetterick 128271 X 2,705,009 3/1955 Plantinga et a1 128269 RICHARD A. GAUDET, Primary Examiner.
CHARLES F. ROSENBAUM, Examiner.
UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3 ,343 ,540
September 26, 196
Frederick P. Siegel It is hereby certified that error appears in the above numbered patent requiring correction and that the said Letters Patent should read as corrected below.
Column 2, line 19, for "25% C." read 25 C.
column 4, lines 23 and Z4, strike wad of absorbent material affixed having a wad of cotton affixed to Signed and sealed this 8th day SEAL) meet:
Edward M. Fletcher, Jr.
testing Officer out "having a stem with a to of" and insert instead at least one end thereof of October 1968.
EDWARD J. BRENNER Commissioner of Patents
Claims (1)
1. A MEDICATIVE APPLICATOR WHICH COMPRISES A STEM HAVING A WAD OF ABSORBENT MATERIAL AFFIXED TO A LEAST ONE END THEREOF, SAID ABSORBENT MATERIAL BEING IMPREGNATED WITH A MIXTURE COMPRISING A MEDICINAL INGREDIENT CARRIED BY A WATER DISPERSIBLE LOW MELTING POINT RESINOUS MATERIAL.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US362927A US3343540A (en) | 1964-04-27 | 1964-04-27 | Swab-type applicator with impregnated medicament |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US362927A US3343540A (en) | 1964-04-27 | 1964-04-27 | Swab-type applicator with impregnated medicament |
Publications (1)
Publication Number | Publication Date |
---|---|
US3343540A true US3343540A (en) | 1967-09-26 |
Family
ID=23428087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US362927A Expired - Lifetime US3343540A (en) | 1964-04-27 | 1964-04-27 | Swab-type applicator with impregnated medicament |
Country Status (1)
Country | Link |
---|---|
US (1) | US3343540A (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3443562A (en) * | 1967-03-08 | 1969-05-13 | Fuller Lab Inc | Swab type applicator |
US3626470A (en) * | 1969-08-28 | 1971-12-07 | Armour Pharma | Diagnostic device for obtaining cytologic samples |
US3826232A (en) * | 1970-09-18 | 1974-07-30 | Pet Chem Inc | Composition and method for the control of fleas on domesticated animals |
US4166108A (en) * | 1977-01-31 | 1979-08-28 | Robert Brown | Styptic composition |
WO1981000356A1 (en) * | 1979-08-13 | 1981-02-19 | R Strickman | Polymeric drug delivery applicators |
US4318907A (en) * | 1978-04-04 | 1982-03-09 | Westwood Pharmaceuticals, Inc. | Method for treating acne vulgaris and compositions useful for that purpose |
US4331653A (en) * | 1977-08-18 | 1982-05-25 | Robert Brown | Composition for a topical cream for curtailing bleeding and treating skin disorders |
US4383986A (en) * | 1981-08-17 | 1983-05-17 | Ortho Pharmaceutical Corporation | Hemorrhoidal compositions |
US4778786A (en) * | 1985-04-03 | 1988-10-18 | Minnetonka, Inc. | Composition for transdermal drug delivery |
US4838851A (en) * | 1986-11-26 | 1989-06-13 | Shabo Alan L | Applicator and package therefor |
EP0327327A2 (en) * | 1988-02-02 | 1989-08-09 | Richardson-Vicks, Inc. | Medicated cleansing pads |
US5846215A (en) * | 1997-12-11 | 1998-12-08 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Antibacterial swabs |
US5958436A (en) * | 1995-12-21 | 1999-09-28 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
US5996780A (en) * | 1997-10-20 | 1999-12-07 | Gurrera; Vivien K. | Cosmetic apparatus |
US6488646B1 (en) | 2001-09-12 | 2002-12-03 | Unilever Home & Personal Care Usa | Swab deliverable actives |
US6494856B1 (en) | 2001-09-12 | 2002-12-17 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Swab deliverable actives |
US20030031727A1 (en) * | 1994-12-21 | 2003-02-13 | Cosmederm Technologies, Llc | Topical product formulations containing strontium for reducing skin irritation |
US20030124202A1 (en) * | 1994-12-21 | 2003-07-03 | Hahn Gary S. | Formulations and methods for reducing skin irritation |
US20040267180A1 (en) * | 2003-06-27 | 2004-12-30 | Beaudry Scott Alexander | Hemostatic cleansing swab |
US20060211978A1 (en) * | 2005-03-15 | 2006-09-21 | Ted Gerard Van Acker Do | Method for treatment of skin diseases and the like |
US20080038377A1 (en) * | 2006-08-09 | 2008-02-14 | Citow Jonathan S | Device for treatment of inflamed tissue |
EP1938782A1 (en) | 2006-12-28 | 2008-07-02 | Henkel AG & Co. KGaA | Make-up remover |
EP2145614A3 (en) * | 1995-06-13 | 2010-03-17 | Zahra Mansouri | Non-irritating moisturizing or skin care composition comprising an antimicrobial agent and an emollient |
US20100330006A1 (en) * | 1995-06-13 | 2010-12-30 | Zahra Mansouri | Antimicrobial lotion compositions |
US20140370513A1 (en) * | 2012-01-31 | 2014-12-18 | Ge Healthcare Uk Limited | Biological sample collection |
US20170071303A1 (en) * | 2015-09-11 | 2017-03-16 | Olson Ip Technologies, Inc. | Travel Kit |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2020107A (en) * | 1934-08-06 | 1935-11-05 | George A Cruickshank | Combination pessary and vaginal suppository |
US2244027A (en) * | 1938-10-31 | 1941-06-03 | Benjamin D Smith | Teat dilator |
US2467884A (en) * | 1944-02-02 | 1949-04-19 | Nathaniel M Elias | Spermicides |
US2579403A (en) * | 1950-06-01 | 1951-12-18 | Slomowitz Julius | Medical bandage |
US2696456A (en) * | 1950-04-24 | 1954-12-07 | Lambert Company | Dual element suppository |
US2705009A (en) * | 1951-11-29 | 1955-03-29 | Johnson & Johnson | Impregnated tip |
-
1964
- 1964-04-27 US US362927A patent/US3343540A/en not_active Expired - Lifetime
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2020107A (en) * | 1934-08-06 | 1935-11-05 | George A Cruickshank | Combination pessary and vaginal suppository |
US2244027A (en) * | 1938-10-31 | 1941-06-03 | Benjamin D Smith | Teat dilator |
US2467884A (en) * | 1944-02-02 | 1949-04-19 | Nathaniel M Elias | Spermicides |
US2696456A (en) * | 1950-04-24 | 1954-12-07 | Lambert Company | Dual element suppository |
US2579403A (en) * | 1950-06-01 | 1951-12-18 | Slomowitz Julius | Medical bandage |
US2705009A (en) * | 1951-11-29 | 1955-03-29 | Johnson & Johnson | Impregnated tip |
Cited By (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3443562A (en) * | 1967-03-08 | 1969-05-13 | Fuller Lab Inc | Swab type applicator |
US3626470A (en) * | 1969-08-28 | 1971-12-07 | Armour Pharma | Diagnostic device for obtaining cytologic samples |
US3826232A (en) * | 1970-09-18 | 1974-07-30 | Pet Chem Inc | Composition and method for the control of fleas on domesticated animals |
US4166108A (en) * | 1977-01-31 | 1979-08-28 | Robert Brown | Styptic composition |
US4331653A (en) * | 1977-08-18 | 1982-05-25 | Robert Brown | Composition for a topical cream for curtailing bleeding and treating skin disorders |
US4318907A (en) * | 1978-04-04 | 1982-03-09 | Westwood Pharmaceuticals, Inc. | Method for treating acne vulgaris and compositions useful for that purpose |
WO1981000356A1 (en) * | 1979-08-13 | 1981-02-19 | R Strickman | Polymeric drug delivery applicators |
US4383986A (en) * | 1981-08-17 | 1983-05-17 | Ortho Pharmaceutical Corporation | Hemorrhoidal compositions |
US4778786A (en) * | 1985-04-03 | 1988-10-18 | Minnetonka, Inc. | Composition for transdermal drug delivery |
US4838851A (en) * | 1986-11-26 | 1989-06-13 | Shabo Alan L | Applicator and package therefor |
EP0327327A2 (en) * | 1988-02-02 | 1989-08-09 | Richardson-Vicks, Inc. | Medicated cleansing pads |
EP0327327A3 (en) * | 1988-02-02 | 1990-07-04 | Richardson-Vicks, Inc. | Medicated cleansing pads |
US20030031727A1 (en) * | 1994-12-21 | 2003-02-13 | Cosmederm Technologies, Llc | Topical product formulations containing strontium for reducing skin irritation |
US8147855B2 (en) | 1994-12-21 | 2012-04-03 | Cosmederm Bioscience, Inc. | Methods for inhibiting sensory responses in the skin such as pain and itch using topical product formulations containing strontium |
US20080131386A1 (en) * | 1994-12-21 | 2008-06-05 | Cosmederm Technologies, Inc. | Topical product formulations containing strontium for reducing skin irritation |
US20100173021A1 (en) * | 1994-12-21 | 2010-07-08 | Cosmederm Technologies, Inc. | Topical Product formulations containing strontium for reducing skin irritation |
US8449923B2 (en) | 1994-12-21 | 2013-05-28 | Cosmederm Bioscience, Inc. | Methods for inhibiting sensory nerves by topically administering strontium-containing compositions to keratinized skin |
US20030124202A1 (en) * | 1994-12-21 | 2003-07-03 | Hahn Gary S. | Formulations and methods for reducing skin irritation |
US7404967B2 (en) | 1994-12-21 | 2008-07-29 | Cosmederm, Inc. | Topical product formulations containing strontium for reducing skin irritation |
US20100330006A1 (en) * | 1995-06-13 | 2010-12-30 | Zahra Mansouri | Antimicrobial lotion compositions |
EP2145614A3 (en) * | 1995-06-13 | 2010-03-17 | Zahra Mansouri | Non-irritating moisturizing or skin care composition comprising an antimicrobial agent and an emollient |
US5958436A (en) * | 1995-12-21 | 1999-09-28 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
US5996780A (en) * | 1997-10-20 | 1999-12-07 | Gurrera; Vivien K. | Cosmetic apparatus |
US5846215A (en) * | 1997-12-11 | 1998-12-08 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Antibacterial swabs |
US5919152A (en) * | 1997-12-11 | 1999-07-06 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Antibacterial swabs |
US6494856B1 (en) | 2001-09-12 | 2002-12-17 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Swab deliverable actives |
US6488646B1 (en) | 2001-09-12 | 2002-12-03 | Unilever Home & Personal Care Usa | Swab deliverable actives |
US20040267180A1 (en) * | 2003-06-27 | 2004-12-30 | Beaudry Scott Alexander | Hemostatic cleansing swab |
US7008392B2 (en) * | 2003-06-27 | 2006-03-07 | Johnson & Johnson Consumer Companies, Inc. | Hemostatic cleansing swab |
US7582067B2 (en) * | 2005-03-15 | 2009-09-01 | Ted Gerard Van Acker | Prepared medication applicator including a swab and a pharmacological active agent |
US20090281472A1 (en) * | 2005-03-15 | 2009-11-12 | Ted Gerard Van Acker Do | Method for treatment of skin diseases and the like |
WO2006101557A3 (en) * | 2005-03-15 | 2009-04-09 | Acker Do Ted Gerard Van | Method for treatment of skin diseases and the like |
WO2006101557A2 (en) * | 2005-03-15 | 2006-09-28 | Do Ted Gerard Van Acker | Method for treatment of skin diseases and the like |
US8133193B2 (en) * | 2005-03-15 | 2012-03-13 | Ted Gerard Van Acker | Method for treatment of skin diseases and the like |
US20060211978A1 (en) * | 2005-03-15 | 2006-09-21 | Ted Gerard Van Acker Do | Method for treatment of skin diseases and the like |
US20080038377A1 (en) * | 2006-08-09 | 2008-02-14 | Citow Jonathan S | Device for treatment of inflamed tissue |
EP1938782A1 (en) | 2006-12-28 | 2008-07-02 | Henkel AG & Co. KGaA | Make-up remover |
US20140370513A1 (en) * | 2012-01-31 | 2014-12-18 | Ge Healthcare Uk Limited | Biological sample collection |
US9382577B2 (en) * | 2012-01-31 | 2016-07-05 | Ge Healthcare Uk Limited | Biological sample collection |
US20170071303A1 (en) * | 2015-09-11 | 2017-03-16 | Olson Ip Technologies, Inc. | Travel Kit |
US10286095B2 (en) * | 2015-09-11 | 2019-05-14 | Olson Ip Technologies, Inc. | Travel kit |
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