US3322775A - Quaternary ammonium salts of [4-(3-aminoalkanoyl) phenoxy] alkanoic acids - Google Patents

Quaternary ammonium salts of [4-(3-aminoalkanoyl) phenoxy] alkanoic acids Download PDF

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US3322775A
US3322775A US326252A US32625263A US3322775A US 3322775 A US3322775 A US 3322775A US 326252 A US326252 A US 326252A US 32625263 A US32625263 A US 32625263A US 3322775 A US3322775 A US 3322775A
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phenoxy
quaternary ammonium
acetic acid
ammonium salts
aminoalkanoyl
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US326252A
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Jr Edward J Cragoe
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Merck and Co Inc
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Merck and Co Inc
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Priority to US326252A priority Critical patent/US3322775A/en
Priority to IL22402A priority patent/IL22402A/en
Priority to BR164186/64A priority patent/BR6464186D0/en
Priority to GB45941/64A priority patent/GB1079496A/en
Priority to DE19641493994 priority patent/DE1493994A1/en
Priority to FR996137A priority patent/FR1445472A/en
Priority to BE656217D priority patent/BE656217A/xx
Priority to CH1520764A priority patent/CH451198A/en
Priority to SE06173/67A priority patent/SE353900B/xx
Priority to SE14301/64A priority patent/SE311917B/xx
Priority to JP42033202A priority patent/JPS511696B1/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/06—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing halogen atoms, or nitro or nitroso groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

3,322,775 QUATERNARY AMMONIUM SALTS F NOALKANOYDPHENOXY] Edward J. Cragoe, In,
[4-(3-AMI- ALKANOIC ACIDS lbansdale, Pa., assignor to Merck & (10., Inc., Rahway, NJ, a corporation of New Jersey No Drawing. Filed Nov. 26, 1963, Ser. No. 326,252 11 Claims. (Cl. 260-294) where R is a member selected from the group consisting of hydrogen, alkyl, trifluoromethyl-lower alkyl, aryl, aralkyl, cycloalkyl, alkylcycloalkyl, phenoxy, phenylthioalkyl, alkylphenyloxy, phenylalkylthio and halophenylalkyl, e.g., methyl, ethyl, propyl, butyl, isopropyl, isobutyl, pentyl, 2,2,2-trifluoroethyl, 3,3,3-trifluoropropyl, 2,2,2-trifiuoroisopropyl, phenyl, benzyl, phenylethyl, cyclopentyl, cyclohexyl, 4-methylcyclohexy1, benzylthio, tolyloxy, phenylethylthio, and 4-chlorobenzyl, each of the R radicals represents a member selected from the group consisting of lower alkyl and, together with the nitrogen atom to which they are attached, a heterocyclic ring selected from the group consisting of l-pyrrolidinyl, piperidino and morpholino, R is a member selected from the group consisting of lower alkyl and benzyl, X is a member selected from the group consistingof hydrogen, halogen, e.g., chlorine, bromine, fluorine and iodine, lower alkyl, lower alkoxy, trifluoromethyl, nitro and, taken together, two X radicals on adjacent carbon atoms of the benzene ring may be combined to form a 1.3-butadienylene chain (i.e., -CH=CHCH=CH). A- is a non-toxic pharmacologically acceptable anion, e.g., halide, i.e., chloride, bromide or iodide, sulfate, etc, m is an integer having a value less than 3, and n is an integer having a value of 15.
The above compounds are prepared by the reaction of a [4-(3aminoalkanoyl)phenoxy]acetic acid with a quaternizing agent according to the following equation:
where AR is a quaternizing agent and R, R R X, A, m and n are as defined above. Suitable quatermzing 3,322,775 Patented May 30, 1967 agents include, for example, alkyl halides and alkyl sulfates, such as methyl iodide, ethyl iodide, dimethyl sulfate, etc. Specific reaction conditions of temperature, pressure, solvent, etc., are not critical to the success of the reaction, but the process has been found to proceed most advantageously using a low molecular weight alcohol as a solvent, for example, methanol or ethanol, and reaction'temperatures of 20-100 C.
The amines employed as starting materials in the process are prepared by the well-known Mannich reaction, which comprises the condensation of formaldehyde or paraformaldehyde with a (4-acylphen-oxy)acetic acid in the presence of an acid addition salt of a secondary amine. Suitable secondary amines are, for example, dialkylamines, such as dimethylamine, piperidine, pyrrolidine and morpholine. The following equation illustrates this method of preparing the amine reactants:
where R, R X, m and n are as defined above, x is an integer having a value of one or a number greater than one and Z is the anion of an organic or inorganic acid, e.g., halide or acetate.
The quaternary ammonium salts of the invention exhibit highly useful diuretic properties and pharmacological studies demonstrate that they possess the unique property among diuretic agents in that they can cause more electrolyte to be excreted than can be caused to be excreted by known diuretic agents. Because of this property, they are useful in the treatment of conditions re-. sulting from an excesively high concentration of electrolyte in the body or an excesively high retention of fluid in the body, such as in the treatment of edematous conditions resulting, for example, from congestive heart failure,
The instant quaternary ammonium salts are also useful as chemical intermediates in the preparation of [4-(2- methylenealkanoyl)phenoxy]acetic acids. The said salts are easily converted to their corresponding methylene derivatives by treating the former with an aqueous solution of a weak base; generally, the reaction is conducted in an aqueous medium but the nature of the solvent is not necessarily critical and we have found that the reaction proceeds most advantageously in any similar media as, for example, in the presence of mixtures of water and organic solvents. While various Weak bases may be used to convert the salts to their corresponding methylene derivatives, I have employed sodium bicarbonate and potassium bicarbonate for this purpose with especially good results. Following the treatment of the quaternary ammonium compound with the weak base the reaction mixture is treated with an acid, for example an aqueous solution of hydrochloric acid, to precipitate the [4-(2 methylene alkanoyl)phenoxy]acetic acid product. The reaction can be illustrated by the following equation:
wherein R, R R X, A m and n are as hereinbefore defined. Like the quaternary ammonium compounds from which they are derived pharmacological studies of the [4-(Z-methylenealkanoyl)phenoxyl]acetic acids depicted as 111 in the above equation demonstrate that they also possess highly active diuretic, natriuretic and chloruretic properties. Furthermore, they possess the unique property among diuretic agents in that they can cause from two to five times more electrolyte to be excreted than can be caused to be excreted by known diuretics. Thus, while most known diuretic agents reach a threshhold or ceiling in the amount of electrolyte they can cause to be excreted (which is not exceeded even when the dose of agent is increased), the [4-(2 methylenealkanoyDphenoxy]acetic acid products can bring .about the excretion of from two to five or more times this ceiling value.
-. A preferred embodiment of the invention is the class of [4-(3-ammoniumalkanoyl)phenoxy]acetic acids depicted infra:
wherein R is a member selected from the group consisting of lower alkyl and trifiuoromethyl-lower alkyl, R and R represent lower alkyl, X and X each represents a member selected from the group consisting of hydrogen, halogen, lower alkyl, trifluoromethyl and, taken together, the X and X radicals may be combined to form a 1,3-butadienylene chain (i.e., -CH=CHCH=CH) and A- is a non-toxic pharmacologically acceptable anion, e.g., halogen. The above-described class of compounds exhibit particularly good diuretic, natriuretic and chloruretic properties and are thus especially useful agents in the treatment of conditions associated with electrolyte and fluid retention.
The following examples illustrate the quaternary ammonium salts of the invention and the methods for their preparation.
EXAMPLE 1 [3-flu0r0-4- [2-(trimethylam moniummethyl) butyryl] phenoxy1-acetz'c acid iodide ring one hour at room temperature the reaction flask is placed in a water bath and the temperature maintained at 50 C. for three hours. The carbon disulfide is then decanted and the residual aluminum complex is added to a mixture of 500 g. of ice and 125 ml. of concentrated hydrochloric acid. There is thus obtained (3-fiuoro-4-butyrylphenoxy)acetic acid which after crystallization from 1,000 ml. of benzene melts at 131.5133.5 C.; the yield is g. (67%).
Analysis-Calculated for C H FO C, 60.00; H, 5.45; F, 7.91. Found: C, 60.29; H, 5.50; F, 7.92.
Step B.-[3-flu0r0-4-[2 (dimer/1ylaminomethyl)buryryl]phenoxy]acetic acid hydr0chI0ride.-In a 100 ml. round flask equipped with an outlet tube suitable for application of intermittent suction, an intimate mixture of (3-fiuoro 4 butyrylphenoxy)acetic acid (9.6 g., 0.04 mole), paraformaldehyde (1.4 g., 0.047 mole), dry dimethylamine hydrochloride (3.56 g., 0.044 mole) and glacial acetic acid (0.5 ml.) is heated on the steam bath for about 1.5 hours. During this period suction is applied for about one minute at 15-minute intervals. The viscous, homogenous mixture obtained is triturated with 100 ml. of ether. The product is recrystallized from a mixture of isopropyl alcohol and ether to give 9.6 g. (73%) of [3- fiuoro-4 [2 (dimethylaminomethyl)butyryl]phenoxy] acetic acid hydrochloride, M.P. 173.5175.5 C.
AnalysisCalculated for C H ClFNO C, 53.97; H, 6.34; N, 4.20. Found: C, 54.16; H, 6.63; N, 4.07.
Step C[3 fiuoro 4 [2 (rrimethylammoniummethyl)-butyr'yl]plzen0xy]acetic acid i0dide.A 300 ml., 3-necked round-bottomed flask fitted with stirrer, condenser, dropping funnel and calcium chloride tube is charged with [3 -fiuoro-4- 2- (dimethylaminomethyl) -butyryl]phenoxy]acetic acid hydrochloride (10.3 g., 0.031 mole) and sodium hydroxide (1.24 g., 0.031 mole) in isopropyl alcohol (100 ml.). Methyl iodide (52 g., 0.366 mole) is added dropwise over two hours while the mixture is stirred and heated at 90 C. on a steam bath. The mixture is cooled and the precipitated sodium chloride is removed by filtration. The filtrate is concentrated by vacuum distillation and treated with ether to obtain [3- fiuoro 4 [2 (trimethylammoniummethyl)butyryl] phenoxy]-acetic acid iodide.
The following example illustrates the method of converting the quaternary ammonium compounds of the invention to their corresponding pharmacologically useful [4-(2methyleneacyl)phenoxy]alkanoic acid counterparts.
EXAMPLE 2 [3-fluor0-4-(Z-meIhyIenebutyryI)plzenoxy]acetic acid The [3 fiuoro 4 [2 (trimethylammoniummethyl) butyryl1phenoxy1acetic acid iodide from Step C of Example 1 is dissolved in water (150 ml.) and saturated aqueous sodium bicarbonate ml.) is added and the mixture heated on the steam bath for 75 minutes. After cooling, the solution is acidified with concentrated hydrochloric acid, extracted with 300 ml. of ether and the ether extract dried over sodium sulfate. The ether is removed in vacuo and the residue (5.4 g.) dissolved in hot benzene (40 ml.), treated with warm cyclohexane ml.) and cooled. The light yellow solid which forms is recrystallized from a mixture of benzene and cyclohexane, filtered and dried to give [3-fiuo1'o-4-(Z-methylenebutyryl)phenoxy] acetic acid, M.P. 8485.5 C. (Corr.).
Analysis.Calculated for C H FO C, 61.90; H, 5.20. Found: C, 62.35; H, 5.35.
By substituting the appropriate (4-alkanoy-lphenoxy) acetic acid for the (3-fiuoro-4-butyrylphenoxy)acetic acid of Example 1 and following the procedure described therein, the corresponding ammonium salt is prepared. The following equation and accompanying table depict the last step in the preparation of the quaternary compounds of the invention and illustrate the starting materials of the process and the products derived therefrom:
It is to be understood that the above examples are illustrative only and the invention is not to be construed as being limited thereto. Any [4-(3-aminoalkanoyl)phenoxyjalkanoic acid falling within the class of amine reactants depicted in the preceding equation may be substituted for the [3-fluoro-4-[2-(dimethylaminomethyl) butyryl]phenoxy] acetic acid of Step C in Example 1 to prepare the corresponding quaternary salt. The said amine reactants are prepared by the Mannich reaction disclosed in Step B and the (4-alk-anoylphenoxy)acetic acids employed as the starting materials ,in preparing the said amines are prepared by the method set forth in Step A of Example 1. It would thus be obvious to one skilled in the art, in view of the methods of preparation set forth in Steps A through C of Example 1, to begin with known reagents and produce the amine reactants necessary to produce the quaternary ammonium salts of the invention.
What is claimed is:
1. A compound of the formula toxic, pharmacologically acceptable anion.
2. A compound of the formula where R, R and R represent lower alkyl, X represents halogen and A- is a non-toxic, pharmacologically acceptable anion.
30 3. A compound of the formula where R, R R X and X represent lower alkyl and A is a non-toxic, pharmacologically acceptable anion.
4. A compound of the formula References Cited UNITED STATES PATENTS 3,121,723 2/1964 Kirchner 260-326.3
ALEX MAZEL, Primary Examiner. 75 JOSE TOVAR, Assistant Examiner.

Claims (1)

1. A COMPOUND OF THE FORMULA
US326252A 1963-11-26 1963-11-26 Quaternary ammonium salts of [4-(3-aminoalkanoyl) phenoxy] alkanoic acids Expired - Lifetime US3322775A (en)

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Application Number Priority Date Filing Date Title
US326252A US3322775A (en) 1963-11-26 1963-11-26 Quaternary ammonium salts of [4-(3-aminoalkanoyl) phenoxy] alkanoic acids
IL22402A IL22402A (en) 1963-11-26 1964-11-04 Quaternary ammonium salts derived from(3-aminoalkanoyl)phenoxy alkanoic acids and method of their preparation
BR164186/64A BR6464186D0 (en) 1963-11-26 1964-11-11 PROCESS FOR THE PREPARATION OF QUATERNARY AMMONIUM SALTS
GB45941/64A GB1079496A (en) 1963-11-26 1964-11-11 Phenoxy alkanoic acids
FR996137A FR1445472A (en) 1963-11-26 1964-11-24 Process for the production of quaternary ammonium salts
DE19641493994 DE1493994A1 (en) 1963-11-26 1964-11-24 Process for the production of phenoxyacetic acid compounds
BE656217D BE656217A (en) 1963-11-26 1964-11-25
CH1520764A CH451198A (en) 1963-11-26 1964-11-25 Process for the preparation of quaternary ammonium salts
SE06173/67A SE353900B (en) 1963-11-26 1964-11-26
SE14301/64A SE311917B (en) 1963-11-26 1964-11-26
JP42033202A JPS511696B1 (en) 1963-11-26 1967-05-26

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BE (1) BE656217A (en)
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CH (1) CH451198A (en)
DE (1) DE1493994A1 (en)
GB (1) GB1079496A (en)
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SE (2) SE311917B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226804A (en) * 1979-03-09 1980-10-07 Dynapol Alpha amino acid dihydrochalcones
US4267165A (en) * 1979-03-09 1981-05-12 Dynapol Comestibles sweetened with alpha amino acid dihydrochalcones
EP0044541A1 (en) * 1980-07-21 1982-01-27 Teijin Limited Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical composition, containing at least one of these compounds

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3121723A (en) * 1955-11-02 1964-02-18 Sterling Drug Inc Lower alkyl n-(tertiary-amino-lower-alkyl) lower alkamates and quaternary ammonium salts thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3121723A (en) * 1955-11-02 1964-02-18 Sterling Drug Inc Lower alkyl n-(tertiary-amino-lower-alkyl) lower alkamates and quaternary ammonium salts thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226804A (en) * 1979-03-09 1980-10-07 Dynapol Alpha amino acid dihydrochalcones
US4267165A (en) * 1979-03-09 1981-05-12 Dynapol Comestibles sweetened with alpha amino acid dihydrochalcones
EP0044541A1 (en) * 1980-07-21 1982-01-27 Teijin Limited Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical composition, containing at least one of these compounds

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BR6464186D0 (en) 1973-07-26
CH451198A (en) 1968-05-15
IL22402A (en) 1968-08-22
JPS511696B1 (en) 1976-01-20
SE353900B (en) 1973-02-19
BE656217A (en) 1965-05-25
GB1079496A (en) 1967-08-16
DE1493994A1 (en) 1969-10-02
SE311917B (en) 1969-06-30

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