US3317603A - Improvement in the preparation of n-vinyl-n-methylacetamide - Google Patents
Improvement in the preparation of n-vinyl-n-methylacetamide Download PDFInfo
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- US3317603A US3317603A US312015A US31201563A US3317603A US 3317603 A US3317603 A US 3317603A US 312015 A US312015 A US 312015A US 31201563 A US31201563 A US 31201563A US 3317603 A US3317603 A US 3317603A
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- vinyl
- methylacetamide
- preparation
- acetaldehyde
- methylamine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Definitions
- the present invention relates to an improved method for the preparation of N-vinyl-N-methylacetamide; more particularly, it relates to the adaptation and improvement of a method used heretofore to prepare N-alkyl-N(1- aIkenyD-acetamides by the addition of acetic anhydride to N-alkylald-imines and the subsequent splitting ofi of acetic acid.
- N-vinyl-N-methylacetamide is a known compound that can be polymerized, under appropriate conditions, to larger molecules possessing rather interesting chemical and physical properties, as disclosed in copending application S.N. 302,481, filed Aug. 15, 1963. So far, however, these useful polymers have not been available on a practical basis to those engaged in the art partly because of the difficulties attendant to the methods heretofore available for the production of themonomer.
- the existing methods for the preparation of N-vinyl-N-methylacetamide are not satisfactory either in terms of yield or of purity of product.
- the preparation of the. monomer by pyrolysis of -N-(beta-acetoxyethyl)methylacetamide, for instance, is notorious for low yields of impure material.
- N-vinyl- N-propylacetamide has been prepared by a method which consists in forming a Schiff base by the condensation of acetaldehyde and n-propylamine and allowing the Schiff base, N-ethylidenepropylamine, to react with acetic anhydride to form an acetoxy derivative from which acetic acid is split in the presence of triethylamine to yield the vinyl monomer.
- the best yields achieved by these reactions are 78% for the condensation and 68% for the combined acetylation and deactylation respectively, an overall yield of 53%.
- the method has been used with slightly lower eltectiveness for the N(1-propenyl) and the N'(1-'butenyl) homologs of the N-vinyl compound.
- the method fails surprisingly to provide the compound in any yield and purity approaching those of the higher homologs just mentioned.
- N-vinyl-N-methylacetamide can be produced in high yield and high purity. It is also an object to provide N-vinyl-N-methylacetamide of monomer grade which can undergo polymerization to solid high molecular weight products.
- CH3GH NCH3 (CHaCO)20 (manor-on,
- reaction mixture was subjected to heat in a process which combined the distillation and thermal cracking steps of the previous example to yield the following fractions:
- the materials used were The ad- The removal of water was accomplished in three stages by addition of 200 g., 100 g. and 155 g. of potassium hydroxide respectively. The total weight of water extracted was 295 g., 99% of theory. The organic phase of the ACETAMIDE N-Vinyl-N-methylacetamide Boiling point. Fraction Weight (g.) C., 12 mm.
- N-Ethylidenemethylamine (769 g., 13.5 moles) and benzene (500 ml.) were added to a five-liter, three-neck flask equipped with stirrer, condenser, dropping funnel and thermometer. bath at 10 C.
- Triethylamine (1400 g., 13.8 moles) was mixed with acetic anhydride (1380 g., 13.5 moles) and the mixture was added dropwise to the flask at a rate to maintain the temperature below 5 C. The contents of the flask were stirred throughout the period required for the addition. for 2.5 days and then heated to reflux for 5 hours.
- EXAMPLE 3 60 1 Preparation of N-vinyl-N-methylacetamide in impure state but capable of purification by recycling.
- the polymer was milled,
- N-vinyl-N-methylacetamide ment, i.e. the heating of the acetaldehyde-methylamine trimer for conversion into N-ethylidenemethylamine, is obviously restricted to the condensation product of these two particular reactants, since such an interfering trimer molecule is not formed when higher amines and aldehydes are used in the preparation of homologs of N-vinyl-N- methylacetamide.
- anhydride-triethylamine mixture products with aqueous potassium carbonate is of benefit in the preparation of any N-(1-alkenyl)-N-(hydrocarbon substituted)-acetamide from the corresponding Schifl base Part of this improve- The washing of the Schifl base-acetic 5 since the object of this treatment is to obtain a distillate pure enough for subsequent polymerization and at the same time to minimize decomposition of the crude product in the pot.
- the benzene and toluene employed in the process are merely examples of inert solvents for the system and that the sodium carbonate functions because it is a mildly alkaline material Which can be replaced by any non-solvent material having aqueous solutions in the pH range of about 7.5 to about 10.5, for example other carbonates, phosphates, salts of certain organic acids, and so on.
- N-vinyl-N- methyl-acetamide wherein methylamine and acetaldehyde are reacted to form N-ethylidenemethylamine and a trimeric condensation product of methylamine and acetaldehyde; which products are extracted with an alkaline hydroxide compound, and wherein the N-ethylidenemethylamine is treated further to convert it into N-vinyl- N-methylacetamide; the improvement which comprises fractionally distilling the trimeric condensation product of methylamine and acetaldehyde to convert it into N- ethylidenemethylamine.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
United States Patent ()fifice 3,317,663 Patented May 2, 1967 The present invention relates to an improved method for the preparation of N-vinyl-N-methylacetamide; more particularly, it relates to the adaptation and improvement of a method used heretofore to prepare N-alkyl-N(1- aIkenyD-acetamides by the addition of acetic anhydride to N-alkylald-imines and the subsequent splitting ofi of acetic acid.
N-vinyl-N-methylacetamide is a known compound that can be polymerized, under appropriate conditions, to larger molecules possessing rather interesting chemical and physical properties, as disclosed in copending application S.N. 302,481, filed Aug. 15, 1963. So far, however, these useful polymers have not been available on a practical basis to those engaged in the art partly because of the difficulties attendant to the methods heretofore available for the production of themonomer. The existing methods for the preparation of N-vinyl-N-methylacetamide are not satisfactory either in terms of yield or of purity of product. The preparation of the. monomer by pyrolysis of -N-(beta-acetoxyethyl)methylacetamide, for instance, is notorious for low yields of impure material. The vinylation of N-methylacetamide with acetylene occurs at best in yields of about 30%. In these conditions, it is not surprising therefore that the polymerization of N-vinyl-N-methylacetamide has led, when attempted at all, to materials of little value in that they generally consist of dark oils of undefined properties.
N-vinyl- N-propylacetamide has been prepared by a method which consists in forming a Schiff base by the condensation of acetaldehyde and n-propylamine and allowing the Schiff base, N-ethylidenepropylamine, to react with acetic anhydride to form an acetoxy derivative from which acetic acid is split in the presence of triethylamine to yield the vinyl monomer. The best yields achieved by these reactions are 78% for the condensation and 68% for the combined acetylation and deactylation respectively, an overall yield of 53%. The method has been used with slightly lower eltectiveness for the N(1-propenyl) and the N'(1-'butenyl) homologs of the N-vinyl compound. In the case of N-vinyl-N-methylacetamide however, the method fails surprisingly to provide the compound in any yield and purity approaching those of the higher homologs just mentioned.
It is therefore an object of this invention to provide a method by which N-vinyl-N-methylacetamide can be produced in high yield and high purity. It is also an object to provide N-vinyl-N-methylacetamide of monomer grade which can undergo polymerization to solid high molecular weight products.
These and other objects which will become apparent in the course of this disclosure have been accomplished by allowing acetaldehyde and methylamine to react to form a mixture of N-ethylidenemethylamine, a Schiff base, with a substantial quantity of cyclic trimer. The trimer is then broken down to the Schitl base 'by slow distillation through a fractional distillation column. The reactions involved so far may be represented as follows:
OHaCHO CHaN'Hz HO OH=NCH| CHsN CHaHC NCH;
CECE;
' by the following reactions:
CH3GH=NCH3 (CHaCO)20 (manor-on,
' OAc coon,
The excellent yields of N-vlnyl-N-methylacetamide that are obtained by this improved process can be ascribed in part to the identification and consequent treatment of the acetaldehyde-methylamine trimer, a stage believed to be peculiar to the preparation of N-vinyl-N-methylacetamide, and to the potassium carbonate washing of the final reaction mixture of Schifi base, acetic anhydride and triethylamine, a step which enhances the stability of any N-alkyl-N-( l-alkenyl)-acetamide that is being produced.
The invention is further illustrated by not limited by the following examples, all parts and percentages given therein being on a weight basis unless otherwise noted.
EXAMPLE 1 Preparation of N-ethylidenem ethylamine Methylamine g., 2.4 moles) was placed in a threeneck flask equipped with a stirrer, Dry-Ice condenser and dropping funnel. The flask was immersed in a Dry-Ice bath. Acetaldehyde (106 g., 2.4 moles) was added dropwise to the stirred reaction mixture. The mixture became very viscous half way through the addition and toluene ml.) was mixed in to facilitate stirring. When the acetaldehyde addition had been completed, the reaction mixture was allowed to warm to 15 C. Potassium hydroxide (50 g.) was added and the mixture was stirred until the hydroxide had dissolved. The aqueous phase was separated (91 g.) and the remaining organic layer was stirred for two hours with potassium hydroxide (50 g.). The organic phase was then decanted into a distilling flask and distillation was effected at atmospheric pressure through a ten-plate Oldershaw column. The following fractions were collected:
K CO was placed in a flask and cooled to C. by immersion in an ice bath. The reaction mixture was also TABLE I.DISTILLAIION OF N-ETHYLIDENEMETHYLAMINE Stillliead Fraction Composition (percent wt.) Fraction Weight Temp. Yield,
(g) 0.) Percent MeNH Toluene MeNCHCH The composition of the fractions was determined by infrared and vapor phase chromatographic analysis.
The residue was a viscous oil which had no unsaturated carbon-nitrogen band at 1675 cm? in its infrared spectrum. product was distilled through a ten-plate Oldershaw column surmounted by a stillhead to which were attached a receiving flask immersed in an acetone-Dry Ice bath and a condenser cooled with acetone-Dry Ice. distilled slowly at a stillhead temperature of 22-24 C., to yield an additional quantity of 51.3 g. N-ethylidenemethylamine. 37.4% to an overall figure of 78%.
reaction mixture was subjected to heat in a process which combined the distillation and thermal cracking steps of the previous example to yield the following fractions:
TABLE II.-DISTILLATION OF ACETALDEHYDE- It was cracked thermally at 70 to 80 C. and the The product In this manner the yield was raised by 25 The aqueous phase was The benzene extracts were com- The benzene solution was then dried by stirring were collected:
EXAMPLE 2 Preparation 0 N-ethylidenemethylamine TABLE III.DISIILLATION OF N-VINYL-N-METHYL- The method of preparation of Example 1 was employed, with the omission of toluene. methylamine (521 g., 16.8 moles) acetaldehyde (730 g., 16.5 moles) and potassium hydroxide (455 g.). dition of acetaldehyde was effected initially at 20 C.
The materials used were The ad- The removal of water was accomplished in three stages by addition of 200 g., 100 g. and 155 g. of potassium hydroxide respectively. The total weight of water extracted was 295 g., 99% of theory. The organic phase of the ACETAMIDE N-Vinyl-N-methylacetamide Boiling point. Fraction Weight (g.) C., 12 mm.
Hg.) Percent in Percent fraction yield The purity of the fractions was determined by vapor phase chromatography. A total yield of 82% N-vinyl-N- methylacetamide was thus produced, a small part of it METHYLAMINE CONDENSAIE Pot Stillhead Weight MeN CHCHa, Fraction Temp. Temp. (g.) Yield C.) 0.) (Percent) A residue weighing 71 g. remained in the distillation flask. The total yield of high purity N-ethylidene methylarnine was thus 85.5% of theory to which may be added the 3% of recoverable material obtained in the first fraction (28 g.).
N-Ethylidenemethylamine (769 g., 13.5 moles) and benzene (500 ml.) were added to a five-liter, three-neck flask equipped with stirrer, condenser, dropping funnel and thermometer. bath at 10 C. Triethylamine (1400 g., 13.8 moles) was mixed with acetic anhydride (1380 g., 13.5 moles) and the mixture was added dropwise to the flask at a rate to maintain the temperature below 5 C. The contents of the flask were stirred throughout the period required for the addition. for 2.5 days and then heated to reflux for 5 hours.
A solution of potassium carbonate (1400 ml. 33%
EXAMPLE 3 60 1 Preparation of N-vinyl-N-methylacetamide in impure state but capable of purification by recycling.
EXAMPLE 4 Polymerization of N-vinyl-N-methylacetamide N-Vinyl-N-methylacetamide (450 g.) was added to a one-liter polymerization pot equipped with anchor-blade stirrer, nitrogen inlet, condenser and drying tube. Azo-diisobutyronitrile (2.25 g.) was added. The polymerization was run at 50 C. for 30 hours under dry nitrogen.
After 17 hours, a solid mass had formed. The polymer was dissolved in acetone (3 liters) and precipitated from the solution with hexane (16 liters). N-vinyl-N-rnethylacetarnide (28.6 g.) was recovered from the hexane by distillation. washed with hexane and dried. The yield was 365 g. corresponding to an 81% conversion of monomer. inherent viscosity, an indication of molecular weight, was
.05 in water and 1.08 in methanol.
The polymer was milled,
The
The process improvement with which this invention is concerned operates at each of the steps of the synthesis The flask was immersed in a cooling The flask was stored at 0 C.
of N-vinyl-N-methylacetamide. ment, i.e. the heating of the acetaldehyde-methylamine trimer for conversion into N-ethylidenemethylamine, is obviously restricted to the condensation product of these two particular reactants, since such an interfering trimer molecule is not formed when higher amines and aldehydes are used in the preparation of homologs of N-vinyl-N- methylacetamide. anhydride-triethylamine mixture products with aqueous potassium carbonate, on the other hand, is of benefit in the preparation of any N-(1-alkenyl)-N-(hydrocarbon substituted)-acetamide from the corresponding Schifl base Part of this improve- The washing of the Schifl base-acetic 5 since the object of this treatment is to obtain a distillate pure enough for subsequent polymerization and at the same time to minimize decomposition of the crude product in the pot.
Finally, it must be pointed out that the benzene and toluene employed in the process are merely examples of inert solvents for the system and that the sodium carbonate functions because it is a mildly alkaline material Which can be replaced by any non-solvent material having aqueous solutions in the pH range of about 7.5 to about 10.5, for example other carbonates, phosphates, salts of certain organic acids, and so on.
What is claimed therefore is:
1. In the process for the preparation of N-vinyl-N- methyl-acetamide wherein methylamine and acetaldehyde are reacted to form N-ethylidenemethylamine and a trimeric condensation product of methylamine and acetaldehyde; which products are extracted with an alkaline hydroxide compound, and wherein the N-ethylidenemethylamine is treated further to convert it into N-vinyl- N-methylacetamide; the improvement which comprises fractionally distilling the trimeric condensation product of methylamine and acetaldehyde to convert it into N- ethylidenemethylamine.
2. The process of claim 1 Where the heat treatment consists in slow fractional distillation of the trimer at a pot temperature greater than the boiling point of N-ethylidenemethylamine.
References Cited by the Examiner UNITED STATES PATENTS 1,926,014 9/1933 Rosenmund 260-561 2,186,976 1/ 1940 Junkmann et al 260-561 2,231,905 2/1941 Hanford et a1 26056l 2,648,709 8/1953 Sletzinger et a1 260-561 3,008,992 11/1961 Lynn et a1 260561 OTHER REFERENCES Breederveld Rec. Trav. Chirn. des Pays-Bas, vol. 79, pp. 401-407 (1960).
Craig et al., In: Weissberger, Technique of Organic Chemistry, vol. 3, 2nd revised ed., Part I Separation and Purification, pp. 150-151, N.Y., Interscience, 1956.
Kahovec, Zeit, Physikal. Chemie, vol. 43B, pp. 364- 374 (1939).
Smolin et a1. s-Triazines and Derivatives, pp. 476-478, N.Y. Interscience, 1959.
Triollais Bul. Soc. Chim. France, 5th Series, vol. 14, pp. 708-716 (1947).
WALTER A. MODANCE, Primary Examiner. NATALIE TROUSOF, Assistant Examiner.
Claims (1)
1. IN THE PROCESS FOR THE PREPARATION OF N-VINYL-NMETHYL-ACETAMIDE WHEREIN METHYLAMINE AND ACETALDEHYDE ARE REACTED TO FORM N-ETHYLIDENIMETHYLAMINE AND A TRIMERIC CONDENSATION PRODUCT OF METHYLAMINE AND ACETALDEHYDE; WHICH PRODUCTS ARE EXTRACTED WITH AN ALKALINE HYDROXIDE COMPOUND, AND WHEREIN THE N-ETHYLIDENEMETHYLAMINE IS TREATED FURTHER TO CONVERT IT INTO N-VINYLN-METHYLACETAMIDEF THE IMPROVEMENT WHICH COMPRISES FRACTIONALLY DISTILLING THE TRIMERIC CONDENSATION PRODUCT OF METHYLAMINE AND ACETALDEHYDE TO CONVERT IT INTO NETHYLIDENEMETHYLAMINE.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US312015A US3317603A (en) | 1963-09-27 | 1963-09-27 | Improvement in the preparation of n-vinyl-n-methylacetamide |
GB39179/64A GB1082017A (en) | 1963-09-27 | 1964-09-25 | Improvements in and relating to the preparation of n-(hydrocarbon substituted)-n-(1-alkenyl)-acetamides |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US312015A US3317603A (en) | 1963-09-27 | 1963-09-27 | Improvement in the preparation of n-vinyl-n-methylacetamide |
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US3317603A true US3317603A (en) | 1967-05-02 |
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US312015A Expired - Lifetime US3317603A (en) | 1963-09-27 | 1963-09-27 | Improvement in the preparation of n-vinyl-n-methylacetamide |
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GB (1) | GB1082017A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3915970A (en) * | 1972-03-24 | 1975-10-28 | Coalite Chem Prod Ltd | Hexahydro-1,3,5-triazines |
US4080379A (en) * | 1975-06-27 | 1978-03-21 | Bayer Aktiengesellschaft | Sulphonamidosalicylaldehydes |
EP0670302A1 (en) * | 1994-03-04 | 1995-09-06 | Bayer Ag | N-acyloxylalkyl carboxylic acid amide and process for their preparation |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1926014A (en) * | 1929-10-31 | 1933-09-05 | Rosenmund Karl Wilhelm | Manufacture of n.n'-diacyl-compounds of ethylene-diamine and its derivatives |
US2186976A (en) * | 1940-01-16 | Tkialkylacetamides having satu | ||
US2231905A (en) * | 1939-03-03 | 1941-02-18 | Du Pont | Aliphatic vinyl tertiary amides |
US2648709A (en) * | 1948-07-02 | 1953-08-11 | Merck & Co Inc | Methyl-chlorpropyl formamide |
US3008992A (en) * | 1959-12-02 | 1961-11-14 | Union Carbide Corp | Process for recovering n-methyl-n-vinylacetamide |
-
1963
- 1963-09-27 US US312015A patent/US3317603A/en not_active Expired - Lifetime
-
1964
- 1964-09-25 GB GB39179/64A patent/GB1082017A/en not_active Expired
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2186976A (en) * | 1940-01-16 | Tkialkylacetamides having satu | ||
US1926014A (en) * | 1929-10-31 | 1933-09-05 | Rosenmund Karl Wilhelm | Manufacture of n.n'-diacyl-compounds of ethylene-diamine and its derivatives |
US2231905A (en) * | 1939-03-03 | 1941-02-18 | Du Pont | Aliphatic vinyl tertiary amides |
US2648709A (en) * | 1948-07-02 | 1953-08-11 | Merck & Co Inc | Methyl-chlorpropyl formamide |
US3008992A (en) * | 1959-12-02 | 1961-11-14 | Union Carbide Corp | Process for recovering n-methyl-n-vinylacetamide |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3915970A (en) * | 1972-03-24 | 1975-10-28 | Coalite Chem Prod Ltd | Hexahydro-1,3,5-triazines |
US4080379A (en) * | 1975-06-27 | 1978-03-21 | Bayer Aktiengesellschaft | Sulphonamidosalicylaldehydes |
EP0670302A1 (en) * | 1994-03-04 | 1995-09-06 | Bayer Ag | N-acyloxylalkyl carboxylic acid amide and process for their preparation |
US5599940A (en) * | 1994-03-04 | 1997-02-04 | Bayer Aktiengesellschaft | N-acyloxyalkyl-carboxamides and process for their preparation |
US5710279A (en) * | 1994-03-04 | 1998-01-20 | Bayer Aktiengesellschaft | N-acyloxyalkyl-carboxamides and process for their preparation |
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Publication number | Publication date |
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GB1082017A (en) | 1967-09-06 |
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