US3285818A - Hair and skin compositions containing pantethine - Google Patents
Hair and skin compositions containing pantethine Download PDFInfo
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- US3285818A US3285818A US365783A US36578364A US3285818A US 3285818 A US3285818 A US 3285818A US 365783 A US365783 A US 365783A US 36578364 A US36578364 A US 36578364A US 3285818 A US3285818 A US 3285818A
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- Prior art keywords
- pantethine
- parts
- hair
- added
- compositions containing
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- DJWYOLJPSHDSAL-UHFFFAOYSA-N Pantethine Natural products OCC(C)(C)C(O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)C(O)C(C)(C)CO DJWYOLJPSHDSAL-UHFFFAOYSA-N 0.000 title claims description 21
- 235000008975 pantethine Nutrition 0.000 title claims description 21
- 239000011581 pantethine Substances 0.000 title claims description 21
- DJWYOLJPSHDSAL-ROUUACIJSA-N pantethine Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)CO DJWYOLJPSHDSAL-ROUUACIJSA-N 0.000 title claims description 21
- 229960000903 pantethine Drugs 0.000 title claims description 21
- 239000000203 mixture Substances 0.000 title description 10
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 14
- 239000002537 cosmetic Substances 0.000 description 10
- 238000002360 preparation method Methods 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 7
- 229940055726 pantothenic acid Drugs 0.000 description 7
- 235000019161 pantothenic acid Nutrition 0.000 description 7
- 239000011713 pantothenic acid Substances 0.000 description 7
- 239000002304 perfume Substances 0.000 description 7
- 230000001256 tonic effect Effects 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000008294 cold cream Substances 0.000 description 6
- 239000006071 cream Substances 0.000 description 6
- 239000003995 emulsifying agent Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 230000002421 anti-septic effect Effects 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 2
- 239000005516 coenzyme A Substances 0.000 description 2
- 229940093530 coenzyme a Drugs 0.000 description 2
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 229940057995 liquid paraffin Drugs 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 229940101267 panthenol Drugs 0.000 description 2
- 235000020957 pantothenol Nutrition 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 description 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000001570 sorbitan monopalmitate Substances 0.000 description 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 description 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/447—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
Definitions
- Pantethine is non-crystalline, almost colorless and odor-less, and stable againstli-ght, heat, and moisture and is soluble in water, alcohol, and glycerol. It is also observed that pantethin-e applied directly to human skin by itself or in a form of a cosmetic is quickly absorbed into the human body. Pantothenic acid is, as is Well known, a vitamin useful for human beings and is a component of coenzyme A which plays a part in the metabolism of a living body.
- pantothenic acid has been also well known that a lack of pantothenic acid in a human body causes various disturbances, and, moreover, there are many reports describing the effectiveness of pantothenic acid in nourishing and beautifying the skin and hair. Accordingly, it has been widely employed recently as a skin nourishing cream and a hair tonic as well as a medicine. Homoilogs of pantot-henic acid, such as panthenol or its esters or ethers, are used in cosmetics for the same purposes.
- pant-ethine an effective component of the cosmetic preparations, is a compound which is more effective than pantothenic acid as a component of coenzyme A, and it can be utilized for a biochemical formation of coenzyme A more quickly than pantothenic acid.
- Pantethine is utilized in vivo more effectively than panthenol and its derivatives which are utilized after changing to pantothenic acid in vivo.
- pantothenic acid is unstable as a free acid, and its calcium salt and sodium salt are so hygroscopic that they gradually lose their activity in a hydrous state, and, particularly on heating, they are considerably decomposed.
- pantethine is stable as an aqueous solution, and slightly decomposed on heating. As described above, pantethine is an excellent material as a component of a cosmetic from the physical, chemical and biochemical viewpoints.
- the cosmetic preparation according to this invention is prepared by adding pantethine by itself, its
- a hydrous alcohol is used for the manufacture of a hair tonic
- an oily or waxy material such as Vaseline, liquid paraffin, vegetable oil, lanolin, or stearyil alcohol is used for the manufacture of a cold cream and a vanishing cream.
- a base further includes the following emulsifiers.
- non-ionic surface-active agents of less than HLB 9 or metallic soap are used for the manufacture of a'cold cream
- non-ionic surface-active agents of more than HLB 10 or water soluble anionic surface-active agents are used for the manufacture of a vanishing cream.
- the emulsifier is dissolved beforehand in the base, and pantethine by itself or its solution is added thereto and agitated to blend.
- the emulsifier is dissolved in an aqueous solution of pantethine, and the resulting solution is added to the base and agitated to be blended.
- the amount of pantethine contained in the cosmetic preparations according to this invention can be varied in a wide range, but preferably it is between S30%.
- Example 1 6 parts of pantethine are dissolved in 30 parts of water, and 0.15 part of salicylic acid, one part of a perfume, and 50 parts of alcohol are added to the resulting solution, whereby a hair tonic is produced.
- Example 2 5 parts of pantethine are dissolved in 50 parts of water, and 0.2 part of salicylic acid, a small quantity of a perfume, and 50 parts of alcohol are added to the resulting solution, whereby a hair tonic is produced.
- Example 3 20 parts of Vaseline, 20 parts of liquid paraffin, 10 parts of olive oil, 8 parts ofceresine, 4 parts of dehydrated lanolin and 3 parts of sorbitan monopa-lmitate are mixed, and to the resulting mixture, a small quantity of an antioxidant and an antiseptic are added and dissolved at 60 C. Then, to the resulting solution, a solution prepared by dissolving 2 parts of pantethine in. 20 parts of water and kept at 60 C. is added, and the mixture so produced is mixed, emulsified, and cooled to 50 C. A perfume is added to the resulting emulsion, whereby a cold cream is produced.
- Example 4 One part of a perfume and a small quantity of an antioxidant are added to 100 parts of olive oil; to the resulting mixture, a solution prepared by dissolving 5 parts of pantethine in 30 parts of glycerol is added; and, to the resulting mixture, 7 parts of 'glyceryl monostearate are added and mixed, whereby a hair tonic is produced.
- Example 5 25 parts of stearyl alcohol, and 25 parts of white Vaseline are mixed and dissolved at C. to form a mixture.
- a cold cream comprising an aqueous emulsion of 5 to. of 'pantethine represented by the formula References Cited by the Examiner UNITED STATES PATENTS 2,625,565 1/1953 Snell et al 260561 OTHER REFERENCES We'bsters 7th New Collegiate Dictionary, G. and C.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Description
United States Patent 3,285,818 HAIR AND SKIN COMPOSITIONS CONTAINING PANTE'IHINE Gcnkichi Ohta, Bunkyo-ku, Tokyo-to, Osamu Nagase,
Katsushika-ku, Tokyo-t0, and Masao Shimizu, Bunkyoku, Tokyo-to, Japan, assignors to Daiichi Seiyaku Kabu- LsIhiki Kaisha, Tokyo-to, Japan, a joint-stock company of apan No Drawing. Filed May 7, 1964, Ser. No. 365,783
. 3 Claims. (Cl. 167-87) This invention relates to novel cosmetic preparations containing pantethine which preparations favorably influence the properties of human skin and hair and furnish the same with what is necessary for the normal metabolism thereof. Pantethine, an effective material in the cosmetic preparations, is represented by the following formula:
CH OH (HO- CH2 (|3CH-C ONE-CH2 CHa-C ONH-CHz-CHr-S-h Pantethine is non-crystalline, almost colorless and odor-less, and stable againstli-ght, heat, and moisture and is soluble in water, alcohol, and glycerol. It is also observed that pantethin-e applied directly to human skin by itself or in a form of a cosmetic is quickly absorbed into the human body. Pantothenic acid is, as is Well known, a vitamin useful for human beings and is a component of coenzyme A which plays a part in the metabolism of a living body.
It has been also well known that a lack of pantothenic acid in a human body causes various disturbances, and, moreover, there are many reports describing the effectiveness of pantothenic acid in nourishing and beautifying the skin and hair. Accordingly, it has been widely employed recently as a skin nourishing cream and a hair tonic as well as a medicine. Homoilogs of pantot-henic acid, such as panthenol or its esters or ethers, are used in cosmetics for the same purposes. It has been known that pant-ethine, an effective component of the cosmetic preparations, is a compound which is more effective than pantothenic acid as a component of coenzyme A, and it can be utilized for a biochemical formation of coenzyme A more quickly than pantothenic acid. Pantethine is utilized in vivo more effectively than panthenol and its derivatives which are utilized after changing to pantothenic acid in vivo.
Furthermore, pantothenic acid is unstable as a free acid, and its calcium salt and sodium salt are so hygroscopic that they gradually lose their activity in a hydrous state, and, particularly on heating, they are considerably decomposed. In contrast, pantethine is stable as an aqueous solution, and slightly decomposed on heating. As described above, pantethine is an excellent material as a component of a cosmetic from the physical, chemical and biochemical viewpoints.
In view of the above described highly desirable characteristics of pantethine as a component of a cosmetic preparation, it is a general object of the present invention to provide various cosmetic preparations containing pa-ntethine as an effective component and simple methods for preparing the same.
It is a specific object to provide a hair tonic, a cold cream, and a vanishing cream each containing pantethine as an effective component.
The foregoing objects have been achieved by the present invention, the specific nature and details of which will be more clearly apparent by reference to the following detailed description concluding with illustrative examples of preparation according to the invention.
In general, the cosmetic preparation according to this invention is prepared by adding pantethine by itself, its
3,285,818 Patented Nov. 15, 1966 ice aqueous solution, or its solution in an organic solvent such as alcohol or polyhydric alcohol such as glycerol or propy-lene glycol to the base of the cosmetic preparation, if necessary, further adding thereto an emulsifier, an antioxidant, an antiseptic, and a perfume, and then dissolving, blending, and dispersing the ingredients. Changes such as decomposition are not observed during the above process steps.
As a base, a hydrous alcohol is used for the manufacture of a hair tonic, and an oily or waxy material such as Vaseline, liquid paraffin, vegetable oil, lanolin, or stearyil alcohol is used for the manufacture of a cold cream and a vanishing cream. A base further includes the following emulsifiers.
As an emulsifier, non-ionic surface-active agents of less than HLB 9 or metallic soap are used for the manufacture of a'cold cream, and non-ionic surface-active agents of more than HLB 10 or water soluble anionic surface-active agents are used for the manufacture of a vanishing cream.
For the manufacture of a cold cream, the emulsifier is dissolved beforehand in the base, and pantethine by itself or its solution is added thereto and agitated to blend. For the manufacture of a vanishing cream, the emulsifier is dissolved in an aqueous solution of pantethine, and the resulting solution is added to the base and agitated to be blended.
The amount of pantethine contained in the cosmetic preparations according to this invention can be varied in a wide range, but preferably it is between S30%.
In order to indicate more fully the nature and details of the invention, the following examples of typical procedure are set forth, it being understood that these examples are presented as illustrative only, and that they are not intended to limit the scope of the invention.
Example 1 6 parts of pantethine are dissolved in 30 parts of water, and 0.15 part of salicylic acid, one part of a perfume, and 50 parts of alcohol are added to the resulting solution, whereby a hair tonic is produced.
Example 2 5 parts of pantethine are dissolved in 50 parts of water, and 0.2 part of salicylic acid, a small quantity of a perfume, and 50 parts of alcohol are added to the resulting solution, whereby a hair tonic is produced.
Example 3 20 parts of Vaseline, 20 parts of liquid paraffin, 10 parts of olive oil, 8 parts ofceresine, 4 parts of dehydrated lanolin and 3 parts of sorbitan monopa-lmitate are mixed, and to the resulting mixture, a small quantity of an antioxidant and an antiseptic are added and dissolved at 60 C. Then, to the resulting solution, a solution prepared by dissolving 2 parts of pantethine in. 20 parts of water and kept at 60 C. is added, and the mixture so produced is mixed, emulsified, and cooled to 50 C. A perfume is added to the resulting emulsion, whereby a cold cream is produced.
Example 4 One part of a perfume and a small quantity of an antioxidant are added to 100 parts of olive oil; to the resulting mixture, a solution prepared by dissolving 5 parts of pantethine in 30 parts of glycerol is added; and, to the resulting mixture, 7 parts of 'glyceryl monostearate are added and mixed, whereby a hair tonic is produced.
Example 5 25 parts of stearyl alcohol, and 25 parts of white Vaseline are mixed and dissolved at C. to form a mixture.
Then 5 parts of pantethine, 12 parts of propylene glycol,
and 33 parts of distilled water containing an oil-in-water type emulsifier, such as 5 parts of po1lyoxyethy1ene-40- monostearate, a small quantity of an antioxidant, and an antiseptic, are heated to 75 C. and added to the above mixture, and the resulting mixture is stirred until it solidities. When this solidified mixture has been coo-led to a temperature lower than 45 C., a perfume is added thereto and blended therewith, whereby a vanishing cream is obtained. I
It should be understood, of course, that the foregoing disclosure in part relates to only particular embodiments and related details of the invention and that it is intended to cover all changes and modifications of these examples and details of the invention herein chosen for the purposes of the disclosure, which do not constitute departures from the spirit and scope of the invention as set forth in the appended claims.
What is'claimed is:
1. A hair tonic compnising an aqueous alcoholic solu- -tion of 5 to 30% of pant-ethine represented by the forsaid solution containing an antiseptic and a perfume as additives.
2. A cold cream comprising an aqueous emulsion of 5 to. of 'pantethine represented by the formula References Cited by the Examiner UNITED STATES PATENTS 2,625,565 1/1953 Snell et al 260561 OTHER REFERENCES We'bsters 7th New Collegiate Dictionary, G. and C.
Merriam 00., Springfield, Mass., 1963, page 577.
JULIAN S. LEVITT, Primary Examiner.
VERA C. CLARKE, Assistant Examiner.
Claims (1)
1. A HAIR TONIC COMPRISING AN AQUEOUS ALCOHOLIC SOLUTION OF 5 TO 30% OF PANTETHINE REPRESENTED BY THE FORMULA
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US365783A US3285818A (en) | 1964-05-07 | 1964-05-07 | Hair and skin compositions containing pantethine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US365783A US3285818A (en) | 1964-05-07 | 1964-05-07 | Hair and skin compositions containing pantethine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US3285818A true US3285818A (en) | 1966-11-15 |
Family
ID=23440342
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US365783A Expired - Lifetime US3285818A (en) | 1964-05-07 | 1964-05-07 | Hair and skin compositions containing pantethine |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US3285818A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5673012A (en) * | 1979-11-20 | 1981-06-17 | Pola Chem Ind Inc | Beautifying cosmetic |
| JPS58128310A (en) * | 1982-01-28 | 1983-07-30 | Dai Ichi Seiyaku Co Ltd | Skin conditioner |
| EP0095615A3 (en) * | 1982-05-17 | 1984-09-26 | S.C. Johnson & Son, Inc. | Skin conditioning composition |
| EP0200208A3 (en) * | 1985-04-29 | 1987-03-18 | Richardson-Vicks, Inc. | Pantethine component for hair permanent waving |
| EP0231925A3 (en) * | 1986-02-07 | 1987-09-09 | Richardson-Vicks, Inc. | Hair care compositions |
| US4786493A (en) * | 1985-11-22 | 1988-11-22 | Estee Lauder Inc. | Hair protection composition |
| US5364885A (en) * | 1992-11-13 | 1994-11-15 | Ahluwalia Gurpreet S | Reduction of hair growth |
| WO2018101502A1 (en) * | 2016-11-30 | 2018-06-07 | 한국해양과학기술원 | Composition for promoting hair growth or hair restoration, containing novel pantetheine-based substance |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2625565A (en) * | 1951-03-28 | 1953-01-13 | Parke Davis & Co | Preparation of thio-alkyl pantothenamides |
-
1964
- 1964-05-07 US US365783A patent/US3285818A/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2625565A (en) * | 1951-03-28 | 1953-01-13 | Parke Davis & Co | Preparation of thio-alkyl pantothenamides |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5673012A (en) * | 1979-11-20 | 1981-06-17 | Pola Chem Ind Inc | Beautifying cosmetic |
| JPS58128310A (en) * | 1982-01-28 | 1983-07-30 | Dai Ichi Seiyaku Co Ltd | Skin conditioner |
| EP0095615A3 (en) * | 1982-05-17 | 1984-09-26 | S.C. Johnson & Son, Inc. | Skin conditioning composition |
| EP0200208A3 (en) * | 1985-04-29 | 1987-03-18 | Richardson-Vicks, Inc. | Pantethine component for hair permanent waving |
| AU580157B2 (en) * | 1985-04-29 | 1989-01-05 | Richardson-Vicks Inc. | Pantethine component for hair permanent waving |
| US4851215A (en) * | 1985-04-29 | 1989-07-25 | Richardson-Vicks Inc. | Pantethine component for hair permanent waving |
| US4786493A (en) * | 1985-11-22 | 1988-11-22 | Estee Lauder Inc. | Hair protection composition |
| EP0223257A3 (en) * | 1985-11-22 | 1989-06-28 | Estee Lauder Inc. | Hair stabilizing composition |
| EP0231925A3 (en) * | 1986-02-07 | 1987-09-09 | Richardson-Vicks, Inc. | Hair care compositions |
| US5364885A (en) * | 1992-11-13 | 1994-11-15 | Ahluwalia Gurpreet S | Reduction of hair growth |
| WO2018101502A1 (en) * | 2016-11-30 | 2018-06-07 | 한국해양과학기술원 | Composition for promoting hair growth or hair restoration, containing novel pantetheine-based substance |
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