US3258489A - N-(1-aminocyclohexylmethyl)anilines and n-(1-nitrocyclohexylmethyl)an-ilines - Google Patents
N-(1-aminocyclohexylmethyl)anilines and n-(1-nitrocyclohexylmethyl)an-ilines Download PDFInfo
- Publication number
- US3258489A US3258489A US287806A US28780663A US3258489A US 3258489 A US3258489 A US 3258489A US 287806 A US287806 A US 287806A US 28780663 A US28780663 A US 28780663A US 3258489 A US3258489 A US 3258489A
- Authority
- US
- United States
- Prior art keywords
- nitrocyclohexylmethyl
- aminocyclohexylmethyl
- grams
- phenylenediamine
- aniline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B5/00—Preserving by using additives, e.g. anti-oxidants
- C11B5/0042—Preserving by using additives, e.g. anti-oxidants containing nitrogen
- C11B5/005—Amines or imines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3526—Organic compounds containing nitrogen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/17—Amines; Quaternary ammonium compounds
- C08K5/18—Amines; Quaternary ammonium compounds with aromatically bound amino groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/16—Nitrogen-containing compounds
- C08K5/32—Compounds containing nitrogen bound to oxygen
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K15/00—Anti-oxidant compositions; Compositions inhibiting chemical change
- C09K15/04—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds
- C09K15/16—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing nitrogen
- C09K15/18—Anti-oxidant compositions; Compositions inhibiting chemical change containing organic compounds containing nitrogen containing an amine or imine moiety
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/925—Natural rubber compositions having nonreactive materials, i.e. NRM, other than: carbon, silicon dioxide, glass titanium dioxide, water, hydrocarbon or halohydrocarbon
Definitions
- the new compounds may be represented by the formula X @CHM R where X is N0 or NH and R is H, alkoxy of l-12 carbon atoms, alkyl of 1-12 carbon atoms, phenylamino, tolylamino, cyclohexylamino, or
- antioxidants for oxidizable substances which deteriorate by absorption of oxygen from the air, as for example rubber, gasoline, soap and vegetable oils. Some of them possess biological properties as hereinafter described.
- N(l-nitrocyclohexylmethyl)anilines form from condensation of nitrocyclohexane, formaldehyde and aniline or substituted aniline. Reduction is preferably ef fected with elemental hydrogen in the presence of a hydrogenation catalyst.
- Compounds with a secondary amino substituent in the cyclohexane ring are also valuable antioxidants. These may be formed by isolating the free amino compound and alkylating in known manner or by reductive alkylation of the nitro compound with an aldehyde or ketone. Examples of compounds available through these reactions comprise N-( 1-isopropylaminocyclohexylmethyl) -N'-phenyl-pphenylenediamine,
- Reduction of the nitro compound is preferably carried out in the presence of finely divided nickel, at temperatures between 4060 C. and hydrogen pressures of 50-80 pounds per square inch. Hydrogenation is preferably continued until hydrogen has been consumed in an amount corresponding approximately to that theoretically re quired for the conversion.
- the method of producing the various products of the invention will be understood from the following description and examples:
- Example 1 A mixture was prepared containing 129.16 grams (1.0 mole) of nitrocyclohexane, 300 m1. of methanol, 93 grams (1.0 mole) of aniline and 5 ml. of benzyl trimethyl ammonium hydroxide. To this stirred mixture maintained at refluxing temperature (70 C.) was added dropwise in 5 hours, 100 grams (1.23 moles) of 37% formaldehyde. During the addition the temperature rose gradually to a maximum of 77 C. After addition was complete, the reaction was stirred at refluxing temperature for 3 hours. After cooling to 0-6 C. and stirring /2 hour longer, the product was filtered and washed with ml. of cold methanol. The precipitate was air-dried at room temperature.
- N(l-nitrocyclohexylmethyl)aniline was obtained as a yellow solid melting at 86 C. after recrystallization from heptane. Analysis gave 12.00% nitrogen (Dumas) compared to 11.96% calculated for C H N O
- Example 2 A mixture of 65.0 grams (0.2 mole) of N-(l-nitrocyclohexylmethyl)aniline produced as described in Example 1, 150 ml. of isopropanol and 12 grams (50% aqueous) of Raney nickel which had been washed twice with isopropanol was charged to an hydrogenator. Hydrogen was fed in at 50-60 pounds per square inch at 45-50 C. until the theoretical amount was taken up. After filtering out catalyst and stripping, yield of N-(l-aminocyclohexylmethyl)aniline was obtained melting at 44-45 C. after recrystallization from heptane.
- Example 3 To a reactor was charged 126 grams (0.975 mole) of nitrocyclohexane, 400 ml. of methanol, 7.5 ml. of benzyl trimethyl ammonium hydroxide and 184 grams (1.0 mole) of p-aminodiphenylamine. The mixture was stirred while adding dropwise at refluxing temperature (70 C.) 100 grams (1.23 moles) of 37% formaldehyde. After addition was complete the reaction was stirred at refluxing temperature for 12 hours. On cooling to 10 C. and seeding with a few crystals of the product of Example 1, the product solidified into light tan crystals. The solid was collected by filtration, washed with 100 ml. of cold methanol and 100 ml.
- Example 5 To a reactor was charged 64.5 grams (0.5 mole) of nitrocyclohexane, 150 ml. of isopropyl alcohol, 27 grams (0.25 mole) of p-phenylenediamine and 5 ml. of 25% sodium hydroxide. The mixture was stirred at 8587 C. while adding dropwise, over a period of 2 hours, 50 grams (0.626 mole) of 37% formaldehyde. A solid began to form after one-half of the formaldehyde had been added. The stirred reaction mixture was heated at 8587 C. for 2 hours, cooled to 5 C. and 150 ml. of cold heptane added. After stirring at 0-10" C.
- Example 7 A mixture of 69.5 grams (0.25 mole) of N-(I-nitrocyclohexylmethyl)-p-phenetidine, prepared as described in Example 6, 150 ml. of isopropanol and 13 grams (50% aqueous) of Raney nickel washed twice with isopropanol was charged to an hydrogenator and the product hydrogenated as herein described. A 93.2% yield of N-(1- aminocyclohexylmethyl)-p-phenetidine was obtained as an amber oil analyzing 10.96% nitrogen compared to 11.28% calculated for C H N O.
- Example 8 To a reactor was charged 60 grams (0.487 mole) of nitrocyclohexane, 200 ml. of methanol, 5 ml. of benzyl trimethyl ammonium hydroxide and 61.5 grams (0.5 mole) of panisidine. To this stirred mixture, maintained at refluxing temperature, was added dropwise in 3 hours, 70 grams (0.78 mole) of 37% formaldehyde. After addition was complete the reaction was stirred at refluxing temperature for 3 more hours and then isolated as described in Example 1. The product thus obtained, N-(l-nitrocyclohexylmethyl)-p-anisidine, was charged to an hydrogenator together with 150 ml.
- N (1 aminocyclohexylmethyl) panisidine was obtained as a tan solid melting at 62 C. after recrystallization from heptane.
- Example 9 A mixture of 48.8 grams (0.125 mole) of N,N-bis(lnitrocyclohexylmethyl)-p-phenylenediamine produced as described in Example 5, 250 ml. of benzene, 150 ml. of isopropanol and 25 grams (50% aqueous) of Raney nickel, which had been washed twice with isopropanol, was charged to a 1-liter Parr pressure reaction apparatus and purged with nitrogen. Hydrogen was then fed in at 70-80 pounds per square inch at 50-60 C. for about 2 hours whereupon the catalyst was collected, washed with isopropanol and the filtrate stripped, finally in vacuo to C. (maximum pot temperature) at about mm.
- N-(l-aminocyclohexylmethyl)-N'-phenyl p phenylenediamine N (1- aminocyclohexylmethyl)-p-phenetidine and N-(l-aminocyclohexylmethyl)-p-anisdine prevented growth of Salmonella typhosa.
- N-(l-aminocyclohexylmethyl)-p-phenetidine and N (1 aminocyclohexylmethyl)-p-anisidine prevented growth of Staphylococcus aural/s while N (1 aminocyclohexylmethyl)- N'-phenyl-p-phenylenediamine prevented growth of this organism at a concentration of 0.01%.
- both the nitro and amino bodies are antioxidants, the amines are more effective and are preferred.
- Substances which can be protected comprise natural rubber, cis-polybutadiene, cis-polyisopropene, butadienestyrene copolymer rubber, butyl rubber, polyethylene, polypropylene, ethylene-propylene copolymer rubber and the like.
- sulfur-vulcanizable rubber compositions stocks were compounded comprising Part by weight Stock B Smoked sheets Carbon black (Philblack O) Zinc oxide N-tort.butyl 2-benzothiazole-sub tenamide 0.
- the ratio of retention of ultimate tensile strength was calculated by arbitrarily assigning a value of 100 to the unprotected control.
- Rubber stocks were compounded comprising Parts by weight Stock F Smoked sheets Carbon black (Philblaek O) Zine oxide 5 Hydrocarbon softener Stearie acid Morpholino thiobenzot zo Sulfur N-(1-aminoeyc1ohexylmethyl) -N phenyleneriiamine ⁇ lie gopweecncc en oxen
- the compositions were cured by heating 45 minutes in a press at 144 C. and then aged 48 hours at 100 C. in an aluminum block (test tube aging). The tensile strength in pounds per square inch before and after aging are set forth below:
- a compound of the formula QSHM R where X is selected from a group consisting of N0 and NH and R is selected from a group consisting of hydrogen, alkoxy of 1 to 12 carbon atoms, alkyl of 1 to 12 carbon atoms, phenylamino, tolylamino, cyclohexylamino and where X has the same significance as before.
Description
United States Patent 3,258,489 N (1 AMINOCYCLOHEXYLMETHYDANILINES AND N (1 NITROCYCLOHEXYLMETHYL)AN- ILINES Darrell D. Mullins, Nitro, W. Va., assignor to Monsanto Company, a corporation of Delaware No Drawing. Filed June 14, 1963, Ser. No. 287,806 8 Claims. (Cl. 260-576) This invention relates to new and useful compositions of matter. The invention particularly relates to N-(laminocyclohexylmethyl)anilines. These compounds may be obtained by reduction of the corresponding N( l-nitrocyclohexylmethyl)anilines which precursers also appear to be new compounds. The N-(l-aminocyclohexylmethyl)anilines are in turn valuable intermediates for the preparation of compounds containing a secondary amino substituent in the 1-position of the cyclohexane ring.
The new compounds may be represented by the formula X @CHM R where X is N0 or NH and R is H, alkoxy of l-12 carbon atoms, alkyl of 1-12 carbon atoms, phenylamino, tolylamino, cyclohexylamino, or
where X has the same significance as before. Besides being valuable intermediates these compounds are antioxidants for oxidizable substances which deteriorate by absorption of oxygen from the air, as for example rubber, gasoline, soap and vegetable oils. Some of them possess biological properties as hereinafter described.
Representative examples of the new compounds are The N(l-nitrocyclohexylmethyl)anilines form from condensation of nitrocyclohexane, formaldehyde and aniline or substituted aniline. Reduction is preferably ef fected with elemental hydrogen in the presence of a hydrogenation catalyst. Compounds with a secondary amino substituent in the cyclohexane ring are also valuable antioxidants. These may be formed by isolating the free amino compound and alkylating in known manner or by reductive alkylation of the nitro compound with an aldehyde or ketone. Examples of compounds available through these reactions comprise N-( 1-isopropylaminocyclohexylmethyl) -N'-phenyl-pphenylenediamine,
N( 1-sec.butylaminocyclohexylmethyl) -N'-phenyl-pphenylenediamine,
N- 1-( 1', 3 '-dimethylbutyl amino cyclohexylmethyl] -N'- phenyl-p-phenylenediamine,
N- l-(l',4'- dimethylpentylamino)cyclohexylmethyl] -N'- phenyl-p-phenylenediamine,
N-[ l- 1',3 -dimethylpentylamino) cyclohexylmethyl] -N'- phenyl-p-phenylenediamine,
N( 1-methylaminocyclohexylmethyl)-N'-phenyl-p-phenylenediamine,
N( l-ethylaminocyclohexyhnethyl) -N'-phenyl-p-phenylenediamine,
N- l-benzylaminocyclohexyl methyl) -N-phenyl-p-phenylenediamine,
N( 1-methylaminocyclohexylmethyl) aniline,
N( 1-ethylaminocyclohexylmethyl) aniline,
N( 1-isopropylaminocyclohexylmethyl) aniline,
N( 1-propylaminocyclohexylmethyl) aniline,
N( 1-sec.-hexylaminocyclohexylmethyl) aniline,
N( l-sec.-octylaminocyclohexylmethyl) aniline,
N( l-dodecylaminocyclohexylmethyl) aniline,
N-( 1-phenylaminocyclohexylmethyl) aniline,
N- l-methylaminocyclohexyhnethyl) -p-isopropoxyaniline,
N( l-methylaminocyclohexylmethyl) -p-hexyloxyaniline,
N- l-methy1amiuocyclohexylmethyl) -p-octyloxyaniline,
N( 1-methylaminocyclohexylmethyl) -p-decyloxyaniline,
N( l-isopropylaminocyclohexylmethyl) -p-phenetidine,
N(1-isopropylaminocyclohexylmethyl)-p-octyloxyaniline,
N( l-phenylaminocyclohexylmethyl) -p-phenetidine and N( 1-cyclohexylaminocyclohexylmethyl) -N'-phenyl-pphenylenediamine.
Reduction of the nitro compound is preferably carried out in the presence of finely divided nickel, at temperatures between 4060 C. and hydrogen pressures of 50-80 pounds per square inch. Hydrogenation is preferably continued until hydrogen has been consumed in an amount corresponding approximately to that theoretically re quired for the conversion. The method of producing the various products of the invention will be understood from the following description and examples:
Example 1 A mixture was prepared containing 129.16 grams (1.0 mole) of nitrocyclohexane, 300 m1. of methanol, 93 grams (1.0 mole) of aniline and 5 ml. of benzyl trimethyl ammonium hydroxide. To this stirred mixture maintained at refluxing temperature (70 C.) was added dropwise in 5 hours, 100 grams (1.23 moles) of 37% formaldehyde. During the addition the temperature rose gradually to a maximum of 77 C. After addition was complete, the reaction was stirred at refluxing temperature for 3 hours. After cooling to 0-6 C. and stirring /2 hour longer, the product was filtered and washed with ml. of cold methanol. The precipitate was air-dried at room temperature. N(l-nitrocyclohexylmethyl)aniline was obtained as a yellow solid melting at 86 C. after recrystallization from heptane. Analysis gave 12.00% nitrogen (Dumas) compared to 11.96% calculated for C H N O Example 2 A mixture of 65.0 grams (0.2 mole) of N-(l-nitrocyclohexylmethyl)aniline produced as described in Example 1, 150 ml. of isopropanol and 12 grams (50% aqueous) of Raney nickel which had been washed twice with isopropanol was charged to an hydrogenator. Hydrogen was fed in at 50-60 pounds per square inch at 45-50 C. until the theoretical amount was taken up. After filtering out catalyst and stripping, yield of N-(l-aminocyclohexylmethyl)aniline was obtained melting at 44-45 C. after recrystallization from heptane.
3 Example 3 To a reactor was charged 126 grams (0.975 mole) of nitrocyclohexane, 400 ml. of methanol, 7.5 ml. of benzyl trimethyl ammonium hydroxide and 184 grams (1.0 mole) of p-aminodiphenylamine. The mixture was stirred while adding dropwise at refluxing temperature (70 C.) 100 grams (1.23 moles) of 37% formaldehyde. After addition was complete the reaction was stirred at refluxing temperature for 12 hours. On cooling to 10 C. and seeding with a few crystals of the product of Example 1, the product solidified into light tan crystals. The solid was collected by filtration, washed with 100 ml. of cold methanol and 100 ml. of cold heptane and air-dried at room temperature. A 91% yield of N-(l-nitrocyclohexylmethyl) N' phenyl p phenylenediamine was obtained melting at 105107 C. after recrystallization from alco- 1101. Analysis gave 12.93% nitrogen (Dumas) compared to 12.91% calculated for C H N O Example 4 Substituting N-( l-nitrocyclohexylmethyl -N'-phenyl-pphenylenediamine prepared according to Example 3 for the N-(l-nitrocyclohexylmethyl)aniline in the procedure of Example 2, N-(l-aminocyclohexylmethyl)-N'-pheny1- p-phenylenediamine was obtained in 100% yield. It may be purified by recrystallization from heptane. The compound, when pure, melts at 99100 C.
Example 5 To a reactor was charged 64.5 grams (0.5 mole) of nitrocyclohexane, 150 ml. of isopropyl alcohol, 27 grams (0.25 mole) of p-phenylenediamine and 5 ml. of 25% sodium hydroxide. The mixture was stirred at 8587 C. while adding dropwise, over a period of 2 hours, 50 grams (0.626 mole) of 37% formaldehyde. A solid began to form after one-half of the formaldehyde had been added. The stirred reaction mixture was heated at 8587 C. for 2 hours, cooled to 5 C. and 150 ml. of cold heptane added. After stirring at 0-10" C. for 15 minutes, the precipitate was collected by filtration, washed with 200 ml. of heptane and air-dried at 2530 C. N,N-bis(1-nitrocyclohexylmethyl)-p-phenylenediamine was obtained in 96% yield as a tan solid melting at 188189 C. after recrystallization from ethyl acetate. Analysis gave 14.20% nitrogen (Dumas) compared to 14.35% calculated for C H N O Example 6 To a reactor was charged 64.5 grams (0.5 mole) of nitrocyclohexane, 200 ml. of methanol, 5 ml. of benzyl trimethyl ammonium hydroxide and 68.5 grams (0.5 mole) of p-phenetidine. To this stirred solution at refluxing temperature (70-74" C.) was added dropwise over a period of 3 hours, 70 grams (0.78 mole) of 37% formaldehyde. The reaction mixture was heated at refluxing temperature for 12 hours, cooled to 05 C. and isolated as described in Example 3. N-(l-nitrocyclohexylmethyl)-p-phenetidine was obtained in 54% yield as a yellow solid melting at 69-71 C. after recrystallization from heptane. Analysis gave 10.98% nitrogen (Dumas) compared to 10.07% calculated for C H N O Example 7 A mixture of 69.5 grams (0.25 mole) of N-(I-nitrocyclohexylmethyl)-p-phenetidine, prepared as described in Example 6, 150 ml. of isopropanol and 13 grams (50% aqueous) of Raney nickel washed twice with isopropanol was charged to an hydrogenator and the product hydrogenated as herein described. A 93.2% yield of N-(1- aminocyclohexylmethyl)-p-phenetidine was obtained as an amber oil analyzing 10.96% nitrogen compared to 11.28% calculated for C H N O.
Example 8 To a reactor was charged 60 grams (0.487 mole) of nitrocyclohexane, 200 ml. of methanol, 5 ml. of benzyl trimethyl ammonium hydroxide and 61.5 grams (0.5 mole) of panisidine. To this stirred mixture, maintained at refluxing temperature, was added dropwise in 3 hours, 70 grams (0.78 mole) of 37% formaldehyde. After addition was complete the reaction was stirred at refluxing temperature for 3 more hours and then isolated as described in Example 1. The product thus obtained, N-(l-nitrocyclohexylmethyl)-p-anisidine, was charged to an hydrogenator together with 150 ml. of isopropanol and 13 grams of 50% aqueous Raney nickel which had been washed twice with isopropanol. After hydrogenating as above-described, N (1 aminocyclohexylmethyl) panisidine was obtained as a tan solid melting at 62 C. after recrystallization from heptane.
Example 9 A mixture of 48.8 grams (0.125 mole) of N,N-bis(lnitrocyclohexylmethyl)-p-phenylenediamine produced as described in Example 5, 250 ml. of benzene, 150 ml. of isopropanol and 25 grams (50% aqueous) of Raney nickel, which had been washed twice with isopropanol, was charged to a 1-liter Parr pressure reaction apparatus and purged with nitrogen. Hydrogen was then fed in at 70-80 pounds per square inch at 50-60 C. for about 2 hours whereupon the catalyst was collected, washed with isopropanol and the filtrate stripped, finally in vacuo to C. (maximum pot temperature) at about mm. The product crystallized during distillation of the solvent and was dried in air to room temperature. N,N'-bis- (l-aminocyclohexylmethyl)-p-phenylenediamine was obtained as light tan crystals melting at l42 C. after recrystallization from dilute ethanol. Analysis gave 16.15% nitrogen compared to 16.95% calculated for zo a-r r- The new compounds disclosed herein are of use in several important applications. In low concentrations some of them are useful for combating microorganisms. For example, at a concentration of 0.1% N-(l-aminocyclohexylmethyl)-N'-phenyl p phenylenediamine, N (1- aminocyclohexylmethyl)-p-phenetidine and N-(l-aminocyclohexylmethyl)-p-anisdine prevented growth of Salmonella typhosa. At this same concentration N-(l-aminocyclohexylmethyl)-p-phenetidine and N (1 aminocyclohexylmethyl)-p-anisidine prevented growth of Staphylococcus aural/s while N (1 aminocyclohexylmethyl)- N'-phenyl-p-phenylenediamine prevented growth of this organism at a concentration of 0.01%.
Although both the nitro and amino bodies are antioxidants, the amines are more effective and are preferred. Substances which can be protected comprise natural rubber, cis-polybutadiene, cis-polyisopropene, butadienestyrene copolymer rubber, butyl rubber, polyethylene, polypropylene, ethylene-propylene copolymer rubber and the like. As illustrative of antioxidant properties in sulfur-vulcanizable rubber compositions stocks were compounded comprising Part by weight Stock B Smoked sheets Carbon black (Philblack O) Zinc oxide N-tort.butyl 2-benzothiazole-sub tenamide 0.
N l-nitrocyclohoxylrnethyl) -N phenyl-p-phenylenediamine N-(l-nitrocyclohexylmethyl) aniline N,N-bis (l-nitrocyclohexylmethyhp-phenylenedinmine ASTM Designation D1206-54T. The ratio of retention of ultimate tensile strength was calculated by arbitrarily assigning a value of 100 to the unprotected control.
Rubber stocks were compounded comprising Parts by weight Stock F Smoked sheets Carbon black (Philblaek O) Zine oxide 5 Hydrocarbon softener Stearie acid Morpholino thiobenzot zo Sulfur N-(1-aminoeyc1ohexylmethyl) -N phenyleneriiamine {lie gopweecncc en oxen The compositions were cured by heating 45 minutes in a press at 144 C. and then aged 48 hours at 100 C. in an aluminum block (test tube aging). The tensile strength in pounds per square inch before and after aging are set forth below:
TABLE II Stock Tensile, Unaged Tensile, Aged Other tests were carried out by aging in an aluminum block at 120 C. and one atmosphere of oxygen pressure. The samples were maintained at a constant elongation of 50% and the stress decay followed. The time in minutes to 50% of the initial stress is recorded below:
TABLE III Minutes to 50% Stock: Retention of stress Anti-exposure cracking tests were conducted by the stress relaxation method for measuring ozone cracking described by Decker and Wise in Rubber World, April 1962, pages 66-69. These are accelerated tests under dynamic conditions which simulate service conditions. The stocks were alternately stretched and relaxed on a reciprocating mechanism which imparted 25% strain to the test pieces 90 times each minute in an atmosphere which contained approximately 25 parts 0 per hundred million. The extent of cracking in a test piece was determined by measuring the forces required to extend the test pieces 100% before and after exposure to ozone. As the strips began to crack the number of stress supporting rubber chains decreased and the force required to extend the strip 100% was reduced. The ratio of this force to the original force was calculated and the ability of the rubber to resist ozone cracking was obtained by a comparison of these numbers. These ratios are referred to as percent of the original modulus.
TABLE IV Hours t0 Indicated Percent 01 Original Modulus Stock It is intended to cover all changes and modifications of the examples of the invention herein chosen for purposes of disclosure which do not constitute departures from the spirit and scope of the invention.
What is claimed is:
1. A compound of the formula QSHM R where X is selected from a group consisting of N0 and NH and R is selected from a group consisting of hydrogen, alkoxy of 1 to 12 carbon atoms, alkyl of 1 to 12 carbon atoms, phenylamino, tolylamino, cyclohexylamino and where X has the same significance as before.
2. A compound of the formula where R is alkyl of 1 to 12 carbon atoms.
3. A compound of the formula where R is alkyl of 1 to 12 carbon atoms.
4. N-(l-aminocyclohexylmethyl)-N-phenyl p phenylenediamine.
5. N-( l-aminocyclohexylmethyl) aniline.
6. N-( l-aminocyclohexylmethyl)-p-phenetidine.
7. N-( l-nitrocyclohexylmethyl) -p-phenetidine.
8. N-(l-nitrocyclohexylmethyl)-N'-phenyl p phenylenediamine.
References Cited by the Examiner UNITED STATES PATENTS 1,900,454 3/1933 Marx et al 260576 X 1,924,441 8/1933 Kranzlein et al 260576 2,111,307 3/1938 Bartram.
2,180,344 11/1939 Blicke 260576 X 2,256,186 9/1941 Bogemann et al 260576 2,393,889 l/1946 Cook et al 260516 X 2,822,396 2/1958 Dent 260576 3,061,585 10/1962 Wilder 260576 X CHARLES B. PARKER, Primary Examiner.
IRVING MARCUS, Examiner.
DALE R. MAHANAND, Assistant Examiner.
Claims (1)
1. A COMPOUND OF THE FORMULA
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US287806A US3258489A (en) | 1963-06-14 | 1963-06-14 | N-(1-aminocyclohexylmethyl)anilines and n-(1-nitrocyclohexylmethyl)an-ilines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US287806A US3258489A (en) | 1963-06-14 | 1963-06-14 | N-(1-aminocyclohexylmethyl)anilines and n-(1-nitrocyclohexylmethyl)an-ilines |
Publications (1)
Publication Number | Publication Date |
---|---|
US3258489A true US3258489A (en) | 1966-06-28 |
Family
ID=23104440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US287806A Expired - Lifetime US3258489A (en) | 1963-06-14 | 1963-06-14 | N-(1-aminocyclohexylmethyl)anilines and n-(1-nitrocyclohexylmethyl)an-ilines |
Country Status (1)
Country | Link |
---|---|
US (1) | US3258489A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3425844A (en) * | 1965-07-09 | 1969-02-04 | Air Prod & Chem | Ultraviolet absorbing composition comprising a formazan |
FR2154559A1 (en) * | 1971-09-23 | 1973-05-11 | Allen & Hanburys Ltd | |
US3975443A (en) * | 1972-06-06 | 1976-08-17 | Allen & Hanburys Limited | 1-(3,4-dichlorobenzamidomethyl)-cyclohexyldimethylamine |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1900454A (en) * | 1930-04-30 | 1933-03-07 | Gen Aniline Works Inc | Dyeing furs, hairs, feathers, and similar articles |
US1924441A (en) * | 1925-11-19 | 1933-08-29 | Gen Aniline Works Inc | Process for preparing cyclohexylamines |
US2111307A (en) * | 1935-09-12 | 1938-03-15 | Monsanto Chemicals | Mineral oil composition |
US2180344A (en) * | 1937-06-21 | 1939-11-21 | Frederick F Blicke | Tertiary n,n-di-cycloalkyl-alkyl amines |
US2256186A (en) * | 1935-10-10 | 1941-09-16 | Gen Aniline & Film Corp | Quaternary nitrogen compounds |
US2393889A (en) * | 1941-11-29 | 1946-01-29 | American Cyanamid Co | Preparation of n, n'-dicycloaliphatic-p-phenylenediamines |
US2822396A (en) * | 1955-03-05 | 1958-02-04 | Ici Ltd | Production of maines |
US3061585A (en) * | 1959-02-16 | 1962-10-30 | Monsanto Chemicals | Alicyclic oxyaniline rubber antidegradants |
-
1963
- 1963-06-14 US US287806A patent/US3258489A/en not_active Expired - Lifetime
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1924441A (en) * | 1925-11-19 | 1933-08-29 | Gen Aniline Works Inc | Process for preparing cyclohexylamines |
US1900454A (en) * | 1930-04-30 | 1933-03-07 | Gen Aniline Works Inc | Dyeing furs, hairs, feathers, and similar articles |
US2111307A (en) * | 1935-09-12 | 1938-03-15 | Monsanto Chemicals | Mineral oil composition |
US2256186A (en) * | 1935-10-10 | 1941-09-16 | Gen Aniline & Film Corp | Quaternary nitrogen compounds |
US2180344A (en) * | 1937-06-21 | 1939-11-21 | Frederick F Blicke | Tertiary n,n-di-cycloalkyl-alkyl amines |
US2393889A (en) * | 1941-11-29 | 1946-01-29 | American Cyanamid Co | Preparation of n, n'-dicycloaliphatic-p-phenylenediamines |
US2822396A (en) * | 1955-03-05 | 1958-02-04 | Ici Ltd | Production of maines |
US3061585A (en) * | 1959-02-16 | 1962-10-30 | Monsanto Chemicals | Alicyclic oxyaniline rubber antidegradants |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3425844A (en) * | 1965-07-09 | 1969-02-04 | Air Prod & Chem | Ultraviolet absorbing composition comprising a formazan |
FR2154559A1 (en) * | 1971-09-23 | 1973-05-11 | Allen & Hanburys Ltd | |
US3975443A (en) * | 1972-06-06 | 1976-08-17 | Allen & Hanburys Limited | 1-(3,4-dichlorobenzamidomethyl)-cyclohexyldimethylamine |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3219702A (en) | Manufacture of aromatic amines by aromatization | |
US3258489A (en) | N-(1-aminocyclohexylmethyl)anilines and n-(1-nitrocyclohexylmethyl)an-ilines | |
DE2502894C3 (en) | Supported ruthenium catalyst | |
CH663410A5 (en) | METHOD FOR PRODUCING DIPHENYLAMINES AND N, N'-DIPHENYL-PHENYLENE DIAMINES. | |
DE1294364B (en) | Process for making urethanes | |
US2193433A (en) | N-poly-hydroxy-alkyl-arylamines | |
DE2335906B2 (en) | PROCESS FOR THE CONTINUOUS PRODUCTION OF N-ALKYLARYLAMINES | |
US3217040A (en) | Process for the preparation of alkylated aromatic amines | |
DE1937526C3 (en) | Process for the preparation of substituted phenylamines | |
US1980102A (en) | Method of manufacturing secondary aromatic amines | |
US3173952A (en) | Tris-(3, 5-dialkyl-4-hydroxybenzyl) amines | |
US2618658A (en) | 2,2-dimethyl-3-hydroxypropylamine and process for its preparation | |
US3488388A (en) | N-substituted aminobenzenecarboxamides | |
US3283006A (en) | N-alicyclicmethyl phenylenediamines | |
DE1005515B (en) | Process to delay or prevent the formation of peroxide or the self-oxidation of organic compounds | |
US3634313A (en) | Antiozonants for rubber | |
US3968080A (en) | N,N'-dialkyl-p-phenylenediamine mixture | |
US2175585A (en) | Preparation of furfurylamines | |
DE2938698A1 (en) | METHOD FOR PRODUCING CIS-2,6-DIMETHYLMORPHOLINE | |
US3453329A (en) | N-polycyclic hydrocarbyl substituted phenylenediamines | |
US2496941A (en) | N-(di-substituted thiocarbamylthio-methylene) aromatic amines | |
US3511805A (en) | Rubber preserved with alicyclicmethyl phenylenediamines | |
US2765313A (en) | Preparation of thioformamides | |
DE2850995A1 (en) | BIS-ALKYLAMINOPHENOXYALKANES AS ANTIDEGRADATING AGENTS IN SERVICE RUBBER | |
DE2030972A1 (en) | Polyethylene molding compound containing an antioxidant |