US3198385A - High pressure medical injection direct from a fluid containing ampule - Google Patents

High pressure medical injection direct from a fluid containing ampule Download PDF

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US3198385A
US3198385A US221775A US22177562A US3198385A US 3198385 A US3198385 A US 3198385A US 221775 A US221775 A US 221775A US 22177562 A US22177562 A US 22177562A US 3198385 A US3198385 A US 3198385A
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ampule
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Palmer M Maxwell
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00Measuring parameters of the user
    • A61M2230/04Heartbeat characteristics, e.g. ECG, blood pressure modulation
    • A61M2230/06Heartbeat rate only
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/12Pressure infusion

Description

g- 3, 1965 P. M. MAXWELL 3,198,335

HIGH PRESSURE MEDICAL INJECTION DIRECT FROM A FLUID CONTAINING AMPULE Filed Sept. 6, 1962 FIG. 7 3 0 34 2 9 Z I l/ ozoio,

INVENTOR PALMER M. MAXWELL ATTORNEYS United States Patent 3,198,385 HIGH PRESSURE MEDICAL INJECTION DIRECT FROM A FLUID C(DNTG AMPULE Palmer M. Maxwell, 'Wymberly Point Drive, Savannah, Ga. Filed Sept. 6, 1962, Ser. No. 221,775 4 Claims. (Cl. 222-41) This invention relates to a novel and useful means for the medical injection of fluids direct from fluid filled ampules of special construction. It is especially adaptable to certain high pressure procedures such as angiography and heart catheterization. It is also adaptable to most routine low-pressure procedures. 7

It teaches the principle of factory packaging of such fluid containing ampules under laboratory controlled sterile environment, and their further containment within a hermetically sealed plastic envelope to prevent contamination prior to use. Such a method of packaging provides simple means for temperature adjustment of the injectable fluid just prior to use; this may be accomplished by placement of the hermetically sealed container in a temperature controlled water-bath or other such means, without danger of contamination.

The fluid. containing ampule and its component parts are constructed of moulded non-toxic, non-pyrogenic, and pliable plastic or other suitable material. The shape of such an ampule and its component parts is such that when its attached flat leader component is introduced between the revolving faces of two parallel and proximal pressure rollers forward linear travel will be assured which, if continued, will pull the attached fluid filled ampule component between such rotating pressure rollers and thereby cause a progressive collapse of its fluid filled central cavity with a resultant pressure discharge of its fluid contents through an attached tube component and its attached surgical needle or surgical catheter. It is obvious that injection pressure at the surgically selected site will be in direct proportion to the rotational speed of the pressure rollers. Any electrical, mechanical, or manual means to cause rotation of the pressure rollers, in combination with such a constructed fluid filled ampule assembly must be considered the basic concept of this invention.

A wide variety of high-pressure injection apparatus has been offered in the past, all of which employ the same means to contain the injectable fluid and permit its pressure injection. The injectable fluid is introduced into a special high-pressure plunger type syringe, to be placed within the power inject mechanism so that when highpressure is applied to the plunger of such a syringe, pressure discharge of its fluid contents will result. Pressure means employed include manual lever, mechanical spring, motor driven linear actuator, hydraulic pressure, air pres sure, and carbon dioxide pressure. Generally, placement and removal of the fluid filled syringe is time consuming, and presents the problem of possible contamination. Most such mechanisms provide means to adjust pressure discharge. Generally they provide for auxiliary control operations such as X-ray exposure start and EKG signal injection start. They also provide for injection fluid temperature regulation by means of a thermostatic controlled heater surrounding the syringe component. I From the foregoing description of my invention and a review of the present state of the art, it should be apparent to anyone versed in the art that my invention is both novel and useful for a wide variety of medical injection procedures.

These, and other features of my invention, will be more clearly understood from the following detailed description and the accompanying drawings, in which like char- ,7 3,198,385 Patented Aug. 3, .1965

acters designate corresponding parts in all figures, and in which: I

FIGURE .1 ,is a side view of the ampule assembly shown in partial cut-out section of its central fluid filled component, and the attached exit tube component, and its attached flat leader component shown in section.

' FIGURE 2 is an end View of the central fluid filled ampule component showing the flat leader ampule com ponent attached.

FIGURE 3 is a top view showing the central fluid filled ampule component passing between two rotating pressure rollers, and indicating a progresive collapse of its central fluid cavity, with fluid discharge from an attached surgical needle or surgical catheter.

. FIGURE 4 is a side view in partial cut-out section showing a power driven mechanism for providing pres sure roller rotation, with the ampule assembly shown in position between such rollers. It shows the micro-switch control modulebeing actuated by the flat leader ampule component.

FIGURE 5 is an end View of the removable pressure rollers, indicating their ribbed cylindrical surface and attachment means to their drive shaft.

' FIGURE 6 is an end view of the removable ampule guide clip showing attachment means to the top of mechanism housing.

FIGURE 7 is a top View of the removable micro-switch module assembly, showing the attachment means to the end of mechanism housing.

These figures, and the following detailed description, disclose a preferred and specific embodiment of my invention, but the invention is not limited to the details disclosed since it may be embodied in other equivalent forms.

The preferred and specific embodiment of this invention teaches the principle of the construction of a fiuid filled ampule assembly capable of being fed between a set of rotating pressure rollers in such a manner as to cause collapse and discharge of its fluid contents at a variety of discharge pressures. The construction of the fluid filled ampule assembly can be best seen in FIGURES l and 2, from which it is seen:

The ampule assembly and its component parts are moulded from non-toxic, non-pyrogenic and pliable plastic or other suitable material. Such an ampule assembly consists of a hollow cylindrical center component '1, having one end closed by a generally spherical wallsurface, having at its central axis an opening into an attached length of hollow tubing 3 terminated on its distal end by a surgical Linden connector 4, and a capping device 5; the opposite end of the generally cylindrical hollow ampule component 1 is to be closed by compression and bonding together of its'sid-e walls so as to form a flat leader component of appreciable length 6, whose function shall be to enable initial engagement between the rotating pressure rollers 9. The hollow cavity 2 thus formed within the central ampule component 1 is then filled under laboratory controlled sterile environment with the medically injectable fluid 7, and the ampule assembly sealed by the placement of capping device 5. The whole liquid filled ampule assembly is now hermetically sealed within a sterile plastic envelope 8 to assure against contamination prior to use, and to provide a safe means for pro-injection temperature regulation of the fluid contents of the ampule. The above described ampules are to be provided in a variety of fluidcontent, and fluid volume as may be required for various procedures.

The basic concept of my invention is best seen from FIGURE 3, from Which'it may be seen:

The previously described fluid filled ampule assembly has its flat leader component 6 fed between two parallel and adjacent pressure rollers 9, which are rotating in opposite directions so as to propel the flat leader ampule component 6 forward in a linear direction which, if continued, will causeithe central fluid filled ampule component 1 to pass between the rotating pressure rollers 9, and thereby progressively collapse the walls of fluid filled cavity 2 and cause the pressure discharge of its fluid contents 7 into the attached hollow tube ampule component 3, and the attached surgical needle 19 or the attached surgical catheter l1, and thence into the sun gically selected site. It should be obvious that the in jection pressure will be in direct proportion to the rotational speed of the pressure rollers 9.

Means to provide the required rotation of the pressure rollers 9 include a motor driven mechanism and associated control components shown in FIGURES 4 through 7, from which it may be seen:

The driven mechanism is housed in a cabinet 12, having a top component 13; a reversible variable speed electric motor 19 is attached to reduction gear from which is extented two parallel vertical drive shafts i5, geared to rotate in opposite directions. These shafts have sets of pins 17 placed at right angle to their shafts as engagement means for removable pressure rollers 9 which have centrally located slots 18 to engage with pins 17, the cylindrical faces of the pressure rollers 9 are vertically ribbed to provided traction when the fiat leader ampule component 6 is placed between their rotating faces. A removable ampule guide 14 having attachment means to the cabinet top 13 is provided to slidably support and properly align the ampule component 1 with the pressure rollers 9. Various relays 21 necessary for control operation are provided, whereby a fixed low-speed rotation is assured in either direction for initial set-up procedure and for removal of the exhausted ampule 1. Such a fixed speed operation is controlled by a reversing switch 25 and a panel push-switch 26-; it also provides a variable high-speed rotation for power inject which is dial calibrated 22 and set by switch 23, control being by means of a remote hand-push 24. Pilot lights 27 are provided to indicate various control conditions.

In addition to the drive mechanism the apparatus has a removable and interchangeable micro-switch module 28, having means 42 for attaching it to the end of cabinet 12. An actuator bar 34 extending vertically through a slot 29 in the top of the module 28 is arranged so that its extending end is contacted by the advancing proximal end of the fiat leader component 6 of the ampule assembly. This actuator bar 39 has a pointer 32 to indicate injection volume on a calibrated scale 33. The internally housed end of the actuator bar 30 is slidably attached at its lower end by a bearing block 31 to a horizontal rod 34 and is held in compression toward the start position adjacent to cabinet 12 by a spring 35. The positions of micro-switches 33, 39 and are adjustable by a screw-slot arrangement 36. In the specific embodiment described, it is the function of micro-switch 38 when actuated by the bearing block to terminate fixed low-speed set-up rotation and to cause pilot-light 27 to indicate a ready condition. The subsequent start of power inject at dial 23 selected speed is accomplished by closure of the remote hand pushswitch 24, which will start the rotation of pressure rollers 9 and thereby cause a progressive collapse of the ampule component 1 with a resultant pressure discharge of liquid contents 7 from the cavity 2 into the attached tubular ampule component 3 and the attached surgical needle 10, or the surgical catheter 11 placed wit in the surgically selected site. Such injection will continue, and when forward travel of the actuator bar 30 causes actuation of micro-switch 39 the X-ray exposure will be initiated, such condition being indicated by pilot light 27. Finally, when micro-switch 40 is actuated, the rotation of the mechanism will stop and terminate power injection, such condition also being indicated by pilot li ht 27. The exhausted ampule now may be removed at a fixed slow speed by the reversal of switch 25 and the closure of panel push-switch 26. The modular and easily changeable feature of the micro-switch assembly permits quick interchange of control modules arranged for a wide variety of auxiliary control operations.

What is claimcd as invention is:.

1. Apparatus for the controlled ejection of fluid comprising, in combination, an ampule having two ends and a hollow interior filled with said fluid, a solid rectangular leader attached to and extending from one end of the ampule, a hollow tube extending from the end of the ampule other than that to which the solid leader is attached and having its hollow interior filled with said fluid and joined to the hollow interior of the ampule, means for closing that end of the hollow tube remote from the ampule, two cylindrical rollers engaging opposite sides of the solid leader and having their centers of rotation parallel to each other in the same plane, means for rotating one cylindrical roller in a clockwise direction while rotating the other cylindrical roller in a counter-clockwise direction so as to impart motion to the ampule between said rollers, and means responsive to the said motion ofthe ampule for selectively limiting the extent of said motion.

2. Apparatus for the controlled ejection of fluid through an opening in a hollow point such as that of a surgical needle comprising, in combination, an ampule structure having a middle segment and two end segments, the middle segment being a pliable material and having a hollow interior filled with said fluid, the first end segment being solid and rectangular in shape and the second end segment being a tube whose hollow interior is filled with said fluid and joins the hollow interior of the middle segment to the interior of said hollow point; two cylindrical rollers positioned on opposite sides of the ampule structure, having their axes of rotation parallel to each other in the same plane and each engaging that segment of the ampule structure adjacent to it with its cylindrical surface; power means for rotating one cylindrical roller clockwise while rotating the other cylindrical roller counter-clockwise;mounting means for mounting the ampule structure for slidable motion along a line of motion perpendicular to the plane containing the axes of rotation of the cylindrical rollers; a control module removable mounted to the power means and having a slot and a rod, each with its center line in the same plane as the line of motion of the ampule structure; an actuator bar with its lower end slidably associated with the rod and with its upper end extending through the slot and into the line of motion of the ampule structure on that side of the two cylindrical rollers most remote from the second end segment; spring means for yieldably forcing the upper end of the actuator bar against that portion of the first end segment most remote from the middle segment; a plurality of microswitches positioned in the line of motion of the lower end of the actuator bar so that each is actuated when engaged by the lower end of the actuator bar; indicating light responsive to the actuation of the plurality of micro-switches; a control switch remote from, but electrically associated with, the power means; and control means responsive to the actuation of the plurality of microswitches and the control switch for controlling the power means and the start, speed, direction and duration of rotation of the cylindrical rollers.

3. An apparatus for the controlled injection of fluid in connection with a medical procedure comprising, in combination, aihollow sack of pliable material filled with said fluid; two rollers engaging opposite sides of said sack and having just sumcient clearance between them to accommodate only the pliable material of the sack; power means for rotating the rollers in opposite directions, said power means being adjustable for various speeds of roller rotation; indicating lights; adjustable switch responsive to the relative position of the sack between rollers for controlling the power means, the il lumination of the indicating lights and the initiation of the medical procedure; and a remote switch means for manually controlling the power means.

4. An apparatus for the controlled injection of fluid through an injection device and in connection with a medical procedure comprising, in combination, an ampule having a hollow portion circular in cross section and filled with said fluid and a solid portion rectangular in cross section; two cylindrical rollers positioned on opposite sides of the ampule and with a distance between their cylindrical surfaces which will permit the cylindrical surfaces to securely grip the solid portion or" the ampule when it is placed between them; power means for rotating the two cylindrical rollers in opposite directions, said power means being adjustable to permit adjustment of the rotation speed of the rollers; means for removably positioning the ampule with its solid portion between the two cylindrical rollers and which permits slidable motion of the ampule toward the cylindrical rollers; a plurality of switch modules, each having a movable actuator bar extending from it, each being rernovably positionable so that the extending end of its actuator bar will be engaged and moved by the solid portion of the ampule as the ampule moves between the cylindrical rollers, each having a scale mounted on it with units related to the volume of fluid in a unit length of the hollow portion of the ampule, each having an indicator associated with its actuator bar and whose position along the scale is related to the length of the ampule extending between the actuator bar and the cylindrical rollers, each having a plurality of microswitches adjustably positioned within it and in locations which will cause said microswitches to be successively activated by motion of the actuator bar, and each differing from other modules in the number of microswitches within it and in the scale units used; and means for controlling the power means in response to the actuation of the microswitches in one of the plurality switch modules or in response to other electrical signals.

References Cited by the Examiner UNITED STATES PATENTS 1,219,265 3/17 Davis 222-95 1,479,101 1/24 Legendre 222-102 1,742,809 1/30 Hoover 222-107 X 2,707,578 5/55 Romano 222-102 X 2,750,719 6/55 Wandelt 53*22 2,941,694 6/60 Harman 222--107 I 2,962,192 11/ Volckening 222l07 3,087,653 4/63 Nolin 222- X FORElGN PATENTS 572,281 6/58 Italy.

588,042 1/59 Italy.

732,761 6/55 Great Britain.

LGUlS I. DEMBO, Primary Examiner.

EVERETT V. KIRBY, Examiner.

Claims (1)

1. APPARATUS FOR THE CONTROLLED EJECTION OF FLUID COMPRISING, IN COMBINATION, AN AMPULE HAVING TWO ENDS AND A HOLLOW INTERIOR FILLED WITH SAID FLUID, A SOLID RECTANGULAR LEADER ATTACHED TO AND EXTENDING FROM ONE END OF THE AMPULE, A HOLLOW TUBE EXTENDING FROM THE END OF THE AMPULE OTHER THAN THAT TO WHICH THE SOLID LEADER IS ATTACHED AND HAVING ITS HOLLOW INTERIOR FILLED WITH SAID FLUID AND JOINED TO THE HOLLOW INTERIOR OF THE AMPULE, MEANS FOR CLOSING THAT END OF THE HOLLOW TUBE REMOTE FROM THE AMPULE, TWO CYLINDRICAL ROLLERS ENGAGING OPPOSITE SIDES OF THE SOLID LEADER AND HAVING THEIR CENTERS OF ROTATION PARALLEL TO EACH OTHER IN THE SAME PLANE, MEANS FOR ROTATING ONE CYLINDRICAL ROLLER IN A CLOCKWISE DIRECTION WHILE ROTATION THE OTHER CYLINDRICAL ROLLER IN A COUNTER-CLOCKWISE DIRECTION SO AS TO IMPART MOTION TO THE
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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044764A (en) * 1975-10-30 1977-08-30 Szabo Anthony W Fluid infusion apparatus
WO1981001658A1 (en) * 1979-12-13 1981-06-25 M Loeb Wearable insulin infusion system having a tubular reservoir and a positive displacement metering means
WO1982003556A1 (en) * 1981-04-24 1982-10-28 Inc Biotek Wearable medication infusion system with arcuate reservoir
US4382753A (en) * 1979-03-09 1983-05-10 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4391600A (en) * 1979-03-09 1983-07-05 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4410322A (en) * 1979-03-09 1983-10-18 Avi, Inc. Nonpulsating TV pump and disposable pump chamber
US4416662A (en) * 1980-06-13 1983-11-22 The United States Of America As Represented By The Department Of Health And Human Services Roller infusion apparatus
US4445826A (en) * 1982-01-22 1984-05-01 Polaroid Corporation Peristaltic pump apparatus
US4601707A (en) * 1980-06-03 1986-07-22 Albisser Anthony M Insulin infusion device
US4842576A (en) * 1986-10-15 1989-06-27 Baxter International Inc. System for generating substantially constant fluid pressure
US4857048A (en) * 1987-05-29 1989-08-15 Hewlett-Packard Company IV pump and disposable flow chamber with flow control
US4911703A (en) * 1986-10-15 1990-03-27 Baxter International Inc. Mobile, self-contained blood collection system and method
US5232439A (en) * 1992-11-02 1993-08-03 Infusion Technologies Corporation Method for pumping fluid from a flexible, variable geometry reservoir
US5232437A (en) * 1986-10-15 1993-08-03 Baxter International Inc. Mobile, self-contained blood collection system and method
US5300015A (en) * 1992-03-03 1994-04-05 Runge Thomas M Blood conduit for pulsatile cardiopulmonary bypass pump
US5320503A (en) * 1988-05-17 1994-06-14 Patient Solutions Inc. Infusion device with disposable elements
US5342313A (en) * 1992-11-02 1994-08-30 Infusion Technologies Corporation Fluid pump for a flexible, variable geometry reservoir
US5427274A (en) * 1992-07-23 1995-06-27 Wood; Robert Product delivery system for delivering sterile liquid product
US5584667A (en) * 1988-05-17 1996-12-17 Davis; David L. Method of providing uniform flow from an infusion device
US5803712A (en) * 1988-05-17 1998-09-08 Patient Solutions, Inc. Method of measuring an occlusion in an infusion device with disposable elements
US6074366A (en) * 1998-01-16 2000-06-13 Tandem Medical Inc. Medication delivery apparatus
US6296150B1 (en) * 1999-02-25 2001-10-02 Barry Farris Medicinal dosing apparatus and method
US20030102327A1 (en) * 2001-12-05 2003-06-05 International Dispensing Corporation Portion Control Dispenser
US6669668B1 (en) 1999-11-05 2003-12-30 Tandem Medical Medication delivery pump
US6726655B1 (en) 1999-11-05 2004-04-27 Tandem Medical Medication delivery system
US20130178825A1 (en) * 2011-01-31 2013-07-11 Robert E. HELM, JR. Catheter-dressing systems with integrated flushing mechanisms

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US2750719A (en) * 1952-04-21 1956-06-19 Ind Radiant Heat Corp Packaging method
US2941694A (en) * 1958-09-15 1960-06-21 Watts Electric & Mfg Co Composite tube structure
US2962192A (en) * 1958-09-10 1960-11-29 Ivers Lee Co Package for fluent commodities
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Publication number Priority date Publication date Assignee Title
US1219263A (en) * 1915-12-03 1917-03-13 Stephen A Ellison Collapsible container.
US1479101A (en) * 1921-10-04 1924-01-01 Legendre Alphonse Prosper Squeezing appliance
US1742809A (en) * 1928-10-02 1930-01-07 Ros P Hoover Dispensing container for liquid medicine
US2750719A (en) * 1952-04-21 1956-06-19 Ind Radiant Heat Corp Packaging method
US2707578A (en) * 1952-11-20 1955-05-03 James A Romano Dispenser for collapsible tubes with tube-collapsing rollers and indicator
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Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4044764A (en) * 1975-10-30 1977-08-30 Szabo Anthony W Fluid infusion apparatus
US4382753A (en) * 1979-03-09 1983-05-10 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4391600A (en) * 1979-03-09 1983-07-05 Avi, Inc. Nonpulsating IV pump and disposable pump chamber
US4410322A (en) * 1979-03-09 1983-10-18 Avi, Inc. Nonpulsating TV pump and disposable pump chamber
WO1981001658A1 (en) * 1979-12-13 1981-06-25 M Loeb Wearable insulin infusion system having a tubular reservoir and a positive displacement metering means
US4601707A (en) * 1980-06-03 1986-07-22 Albisser Anthony M Insulin infusion device
US4416662A (en) * 1980-06-13 1983-11-22 The United States Of America As Represented By The Department Of Health And Human Services Roller infusion apparatus
WO1982003556A1 (en) * 1981-04-24 1982-10-28 Inc Biotek Wearable medication infusion system with arcuate reservoir
US4525164A (en) * 1981-04-24 1985-06-25 Biotek, Inc. Wearable medication infusion system with arcuated reservoir
US4445826A (en) * 1982-01-22 1984-05-01 Polaroid Corporation Peristaltic pump apparatus
US4842576A (en) * 1986-10-15 1989-06-27 Baxter International Inc. System for generating substantially constant fluid pressure
US4911703A (en) * 1986-10-15 1990-03-27 Baxter International Inc. Mobile, self-contained blood collection system and method
US5232437A (en) * 1986-10-15 1993-08-03 Baxter International Inc. Mobile, self-contained blood collection system and method
US4857048A (en) * 1987-05-29 1989-08-15 Hewlett-Packard Company IV pump and disposable flow chamber with flow control
US6146109A (en) * 1988-05-17 2000-11-14 Alaris Medical Systems, Inc. Infusion device with disposable elements
US5803712A (en) * 1988-05-17 1998-09-08 Patient Solutions, Inc. Method of measuring an occlusion in an infusion device with disposable elements
US5320503A (en) * 1988-05-17 1994-06-14 Patient Solutions Inc. Infusion device with disposable elements
US6742992B2 (en) 1988-05-17 2004-06-01 I-Flow Corporation Infusion device with disposable elements
US5584667A (en) * 1988-05-17 1996-12-17 Davis; David L. Method of providing uniform flow from an infusion device
US6312227B1 (en) 1988-05-17 2001-11-06 I-Flow Corp. Infusion device with disposable elements
US5300015A (en) * 1992-03-03 1994-04-05 Runge Thomas M Blood conduit for pulsatile cardiopulmonary bypass pump
US5427274A (en) * 1992-07-23 1995-06-27 Wood; Robert Product delivery system for delivering sterile liquid product
US5232439A (en) * 1992-11-02 1993-08-03 Infusion Technologies Corporation Method for pumping fluid from a flexible, variable geometry reservoir
US5342313A (en) * 1992-11-02 1994-08-30 Infusion Technologies Corporation Fluid pump for a flexible, variable geometry reservoir
US6146360A (en) * 1998-01-16 2000-11-14 Tandem Medical, Inc. Medication delivery apparatus
US6416496B1 (en) 1998-01-16 2002-07-09 Tandem Medical, Inc. Medication delivery apparatus
US6074366A (en) * 1998-01-16 2000-06-13 Tandem Medical Inc. Medication delivery apparatus
US6296150B1 (en) * 1999-02-25 2001-10-02 Barry Farris Medicinal dosing apparatus and method
US6547099B1 (en) 1999-02-25 2003-04-15 Barry Farris Medicinal dosing apparatus and method
US6669668B1 (en) 1999-11-05 2003-12-30 Tandem Medical Medication delivery pump
US6726655B1 (en) 1999-11-05 2004-04-27 Tandem Medical Medication delivery system
US20030102327A1 (en) * 2001-12-05 2003-06-05 International Dispensing Corporation Portion Control Dispenser
US6659309B2 (en) * 2001-12-05 2003-12-09 International Dispensing Corporation Portion control dispenser
US20130178825A1 (en) * 2011-01-31 2013-07-11 Robert E. HELM, JR. Catheter-dressing systems with integrated flushing mechanisms
US9180275B2 (en) * 2011-01-31 2015-11-10 Robert E. Helm Catheter-dressing systems with integrated flushing mechanisms

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