US3172912A - Haloacetylenic amines - Google Patents
Haloacetylenic amines Download PDFInfo
- Publication number
- US3172912A US3172912A US3172912DA US3172912A US 3172912 A US3172912 A US 3172912A US 3172912D A US3172912D A US 3172912DA US 3172912 A US3172912 A US 3172912A
- Authority
- US
- United States
- Prior art keywords
- methyl
- chloro
- butyne
- bromo
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001412 amines Chemical class 0.000 title description 24
- 150000001875 compounds Chemical class 0.000 claims description 36
- 239000002253 acid Substances 0.000 claims description 32
- 239000011780 sodium chloride Substances 0.000 claims description 30
- 238000007792 addition Methods 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 24
- -1 thiornorpholino Chemical group 0.000 description 98
- 125000000217 alkyl group Chemical group 0.000 description 36
- 238000004458 analytical method Methods 0.000 description 28
- 239000000460 chlorine Substances 0.000 description 28
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 28
- 150000003840 hydrochlorides Chemical class 0.000 description 28
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- 125000003342 alkenyl group Chemical group 0.000 description 18
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 16
- 239000011541 reaction mixture Substances 0.000 description 16
- 125000003118 aryl group Chemical group 0.000 description 14
- 239000002585 base Substances 0.000 description 14
- 125000000753 cycloalkyl group Chemical group 0.000 description 14
- XEKOWRVHYACXOJ-UHFFFAOYSA-N acetic acid ethyl ester Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- 125000000392 cycloalkenyl group Chemical group 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- 239000001257 hydrogen Substances 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- ODZPKZBBUMBTMG-UHFFFAOYSA-N Sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 10
- 125000003545 alkoxy group Chemical group 0.000 description 10
- 239000007788 liquid Substances 0.000 description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 10
- 125000002950 monocyclic group Chemical group 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- VZGDMQKNWNREIO-UHFFFAOYSA-N Carbon tetrachloride Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 8
- CDVHNKWGLUSIQI-UHFFFAOYSA-N ClC#CC(C)(C)NC(C)(C)C Chemical compound ClC#CC(C)(C)NC(C)(C)C CDVHNKWGLUSIQI-UHFFFAOYSA-N 0.000 description 8
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 8
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 8
- 125000004432 carbon atoms Chemical group C* 0.000 description 8
- 229910052801 chlorine Inorganic materials 0.000 description 8
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 8
- 230000000875 corresponding Effects 0.000 description 8
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 8
- 238000001704 evaporation Methods 0.000 description 8
- 125000005843 halogen group Chemical group 0.000 description 8
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 8
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
- 238000010992 reflux Methods 0.000 description 8
- 159000000000 sodium salts Chemical class 0.000 description 8
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-Bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 229910052783 alkali metal Inorganic materials 0.000 description 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 6
- 238000004821 distillation Methods 0.000 description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 230000036571 hydration Effects 0.000 description 6
- 238000006703 hydration reaction Methods 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 6
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 238000001953 recrystallisation Methods 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 4
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-Toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- YJZXVJCBQCXSLF-UHFFFAOYSA-N BrC#CC(C)(C)NC(C)(C)C Chemical compound BrC#CC(C)(C)NC(C)(C)C YJZXVJCBQCXSLF-UHFFFAOYSA-N 0.000 description 4
- NMCUIPGRVMDVDB-UHFFFAOYSA-L Iron(II) chloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N P-Toluenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 4
- 230000002378 acidificating Effects 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 239000002220 antihypertensive agent Substances 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 230000003197 catalytic Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- VXAWCKIQYKXJMD-UHFFFAOYSA-N ethynamine Chemical compound NC#C VXAWCKIQYKXJMD-UHFFFAOYSA-N 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000012458 free base Substances 0.000 description 4
- 230000002140 halogenating Effects 0.000 description 4
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 4
- 239000000543 intermediate Substances 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 125000004433 nitrogen atoms Chemical group N* 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 230000003389 potentiating Effects 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000007858 starting material Substances 0.000 description 4
- 125000003107 substituted aryl group Chemical group 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- MNFORVFSTILPAW-UHFFFAOYSA-N Β-Lactam Chemical compound O=C1CCN1 MNFORVFSTILPAW-UHFFFAOYSA-N 0.000 description 4
- CRPTXKKKIGGDBX-UHFFFAOYSA-N (Z)-but-2-ene Chemical group [CH2]C=CC CRPTXKKKIGGDBX-UHFFFAOYSA-N 0.000 description 2
- ZLMNRPCLXQDADC-UHFFFAOYSA-N 2,4-dinitrobenzoic acid Chemical compound OC(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O.OC(=O)C1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O ZLMNRPCLXQDADC-UHFFFAOYSA-N 0.000 description 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 2
- 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 description 2
- CPBZARXQRZTYGI-UHFFFAOYSA-N 3-cyclopentylpropylcyclohexane Chemical compound C1CCCCC1CCCC1CCCC1 CPBZARXQRZTYGI-UHFFFAOYSA-N 0.000 description 2
- 125000005917 3-methylpentyl group Chemical group 0.000 description 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N Azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- YMMCMXIGTONKSO-UHFFFAOYSA-N BrC#CC(CC)(C)NC1=CC=CC=C1 Chemical compound BrC#CC(CC)(C)NC1=CC=CC=C1 YMMCMXIGTONKSO-UHFFFAOYSA-N 0.000 description 2
- CNIVMHUSEVRORX-UHFFFAOYSA-N BrC#CC(CC)(CC)NCC Chemical compound BrC#CC(CC)(CC)NCC CNIVMHUSEVRORX-UHFFFAOYSA-N 0.000 description 2
- IPIMATNRXFFRPR-UHFFFAOYSA-N BrC#CC(CCC)(CC)NC1=CC=C(C=C1)O.N1(CCCC1)C1=CC=C(NC2(CCCCCC2)C#CCl)C=C1 Chemical compound BrC#CC(CCC)(CC)NC1=CC=C(C=C1)O.N1(CCCC1)C1=CC=C(NC2(CCCCCC2)C#CCl)C=C1 IPIMATNRXFFRPR-UHFFFAOYSA-N 0.000 description 2
- OKIPAMXFGLXSEV-UHFFFAOYSA-N C(C)CC(C#CBr)(C)N Chemical compound C(C)CC(C#CBr)(C)N OKIPAMXFGLXSEV-UHFFFAOYSA-N 0.000 description 2
- HDAHZQGVBJZIEM-UHFFFAOYSA-N C(C)NC1(CCCCC1)C#CBr Chemical compound C(C)NC1(CCCCC1)C#CBr HDAHZQGVBJZIEM-UHFFFAOYSA-N 0.000 description 2
- NLISJXRKXNSLFC-UHFFFAOYSA-N C(CCC)NC#CC(C)C Chemical compound C(CCC)NC#CC(C)C NLISJXRKXNSLFC-UHFFFAOYSA-N 0.000 description 2
- MFCSKUWQILTMHQ-UHFFFAOYSA-N CN(C(C#CBr)(C)C)C(C)(C)C Chemical compound CN(C(C#CBr)(C)C)C(C)(C)C MFCSKUWQILTMHQ-UHFFFAOYSA-N 0.000 description 2
- AUVUYGWJZGBGDW-UHFFFAOYSA-N CN(C(C#CBr)(C)C)CC Chemical compound CN(C(C#CBr)(C)C)CC AUVUYGWJZGBGDW-UHFFFAOYSA-N 0.000 description 2
- KVDKFVIPRCEMPH-UHFFFAOYSA-N CN(C(C#CBr)(C)C)NC(C)(C)C Chemical compound CN(C(C#CBr)(C)C)NC(C)(C)C KVDKFVIPRCEMPH-UHFFFAOYSA-N 0.000 description 2
- 210000003169 Central Nervous System Anatomy 0.000 description 2
- WEBFWUJRJJVULL-UHFFFAOYSA-N Cl.BrC#CC(C)(C)NC(C)(C)C Chemical compound Cl.BrC#CC(C)(C)NC(C)(C)C WEBFWUJRJJVULL-UHFFFAOYSA-N 0.000 description 2
- JSJKIQIJYNUREX-UHFFFAOYSA-N Cl.CN(C(C#C)(C)C)CC Chemical compound Cl.CN(C(C#C)(C)C)CC JSJKIQIJYNUREX-UHFFFAOYSA-N 0.000 description 2
- VHLHSOSXXJDCAO-UHFFFAOYSA-N Cl.NC#C Chemical compound Cl.NC#C VHLHSOSXXJDCAO-UHFFFAOYSA-N 0.000 description 2
- HKLZMNHRLASLDI-UHFFFAOYSA-N ClC#CC(C(C)C)(C)NC(C)C Chemical compound ClC#CC(C(C)C)(C)NC(C)C HKLZMNHRLASLDI-UHFFFAOYSA-N 0.000 description 2
- XPGRMHXAVAOMRE-UHFFFAOYSA-N ClC#CC(CCCC)(C)NC(C)(C)C Chemical compound ClC#CC(CCCC)(C)NC(C)(C)C XPGRMHXAVAOMRE-UHFFFAOYSA-N 0.000 description 2
- NYRFOVBCPAKXMM-UHFFFAOYSA-N ClC#CC(CCCCCCCCCCCC)(C1=C(C=CC=C1)Cl)NC Chemical compound ClC#CC(CCCCCCCCCCCC)(C1=C(C=CC=C1)Cl)NC NYRFOVBCPAKXMM-UHFFFAOYSA-N 0.000 description 2
- VHYORFXZNBEMAU-UHFFFAOYSA-N ClC#CC(NC(C)(C)C)C1=CC=CC=C1 Chemical compound ClC#CC(NC(C)(C)C)C1=CC=CC=C1 VHYORFXZNBEMAU-UHFFFAOYSA-N 0.000 description 2
- HSRPEVPTIGYFKX-UHFFFAOYSA-N ClC1(CCC2=CC=CC=C12)C#C Chemical compound ClC1(CCC2=CC=CC=C12)C#C HSRPEVPTIGYFKX-UHFFFAOYSA-N 0.000 description 2
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N Cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-XIXRPRMCSA-N Mesotartaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-XIXRPRMCSA-N 0.000 description 2
- PSIOAFYUECKQAZ-UHFFFAOYSA-N N-butyl-2-methylbut-3-yn-2-amine Chemical compound CCCCNC(C)(C)C#C PSIOAFYUECKQAZ-UHFFFAOYSA-N 0.000 description 2
- HTWJRJQUAYBYHH-UHFFFAOYSA-N NC(C#CBr)(C(C)C)C(C)C Chemical compound NC(C#CBr)(C(C)C)C(C)C HTWJRJQUAYBYHH-UHFFFAOYSA-N 0.000 description 2
- FEMRXDWBWXQOGV-UHFFFAOYSA-N Potassium amide Chemical compound [NH2-].[K+] FEMRXDWBWXQOGV-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000000219 Sympatholytic Substances 0.000 description 2
- 239000000150 Sympathomimetic Substances 0.000 description 2
- 235000011054 acetic acid Nutrition 0.000 description 2
- HSFWRNGVRCDJHI-UHFFFAOYSA-N acetylene Chemical compound C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 2
- 125000003158 alcohol group Chemical group 0.000 description 2
- 230000001476 alcoholic Effects 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 125000005418 aryl aryl group Chemical group 0.000 description 2
- 125000004429 atoms Chemical group 0.000 description 2
- 150000001539 azetidines Chemical class 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000007810 chemical reaction solvent Substances 0.000 description 2
- 125000001047 cyclobutenyl group Chemical group C1(=CCC1)* 0.000 description 2
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 description 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 2
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 2
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- PSLIMVZEAPALCD-UHFFFAOYSA-N ethanol;ethoxyethane Chemical compound CCO.CCOCC PSLIMVZEAPALCD-UHFFFAOYSA-N 0.000 description 2
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 2
- 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N fumaric acid Chemical compound OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000001077 hypotensive Effects 0.000 description 2
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 2
- 239000011630 iodine Substances 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 125000000468 ketone group Chemical group 0.000 description 2
- 150000002576 ketones Chemical class 0.000 description 2
- 239000011976 maleic acid Substances 0.000 description 2
- 125000005394 methallyl group Chemical group 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 125000001624 naphthyl group Chemical group 0.000 description 2
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- GRYLNZFGIOXLOG-UHFFFAOYSA-N nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 125000003367 polycyclic group Chemical group 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- 239000011973 solid acid Substances 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 125000005504 styryl group Chemical group 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 125000001424 substituent group Chemical group 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000001384 succinic acid Substances 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- 230000001975 sympathomimetic Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 229960001367 tartaric acid Drugs 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- 125000003944 tolyl group Chemical group 0.000 description 2
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 125000001834 xanthenyl group Chemical group C1=CC=CC=2OC3=CC=CC=C3C(C12)* 0.000 description 2
- 125000005023 xylyl group Chemical group 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/40—Radicals substituted by oxygen atoms
- C07D307/42—Singly bound oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/66—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
- C07D311/82—Xanthenes
- C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
- C07D311/88—Nitrogen atoms
Definitions
- R and R when taken separately, can be hydrogen, C -C alkyl, C C alkenyl, lower alkoxy-substituted C C alkyl, lower alkoxy substituted C C alkenyl, cycloalkyl, cycloalkenyl, aryl, and substituted aryl, and when taken together with the carbon atoms to which they are attached, can be cycloalkyl, cycloalkenyl, polycyclic aryl, and partially hydrogenated polycyclic aryl;
- R and R when taken separately, can be hydrogen, C C alkyl, C C alkenyl, cycloalkyl, cycloalkenyl, aryl, substituted aryl and aralkyl, and when taken together with the nitrogen atom to which they are attached, can be morpholino, thiornorpholino, piperidino, pyrrolidino and 4-alkylpiperazino;
- R, R R and R are C -C alkyl radicals, they can be illustratively methyl, ethyl, isopropyl, n-butyl, n amyl, 3-methylpentyl, Z-ethylhexyl, n-decyl, sec-hexyl, isooctyl, 4-ethyloctyl, 6-ethyldecyl, undecyl, 2,3,3-trimethylpentyl, neopentyl and the like; and when they represent C C alkenyl radicals, they can be illustratively allyl, methallyl, crotyl, and the like.
- Lower alkoXy-substit-uted C C alkyl radicals or lower alkoxy substituted C C alkenyl radicals, which R and R can represent are in general, formed by substituting any of the C -C alkyl or C -C alkenyl radicals illustrated above with an alkoxy group.
- Illustrative radicals thus formed include methoXyallyl, ethoxyethyl, methoxypropyl, isopropoxydecyl, S-butoxy-Z-pentenyl and the like.
- R, R R and R are aromatic radicals, they can be illustratively phenyl, thienyl, furyl, pyridyl, naphthyl and the like, and permissible substituents in these aromatic rings include halogen, C C alkyl, C alkenyl, nitro, perhaloalkyl, acetarnido, alkoxy, di-alkylamino, and the like.
- Illustrative substituted aromatic radicals which R, R R and R represent thus include a-bromonaphthyl, Z-chlorophenyl, Z-hydroxyfuryl, indenyl, 2 dimethylaminopyridyl, bromothienyl, tolyl, xylyl, allylphenyl, styryl, trifluoromethylphenyl, pentafluoro-ethylphenyl, trichloromethylphenyl, p-(n-heXyDphenyl, S-ethyl-S-acetylaminopyridyl, nitrothienyl, 3-rnethylfuryl, anisyl, ethoxyphenyl, methoxyfuryl, 3-n-butylphenyl, etc.
- aromatic is used herein in its conventional sense and includes all radicals having aromatic character. (See for example Chapter 3 of Organic Chemistry, Henry Gilman, editor, 2d edition, John Wiley and Sons, New York, 1943.)
- R, R R and R when they repreesnt cycloalkyl radicals or cycloalkenyl radicals can be illustratively cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclo-octyl, methylcyclopentyl, cyclobutenyl, bicyclo[2.2.l]heptyl, cy-
- R and R represent aralkyl radicals
- they can be, illustratively, benzyl, phenethyl, 2-phenylpropy1, 1- henylethyl, l-tolylethyl, m-chlorobenzyl, p-anisylrnethyl, homoveratryl and the like, the permissible aryl radicals substituted in the alkyl chain being in general those defined above for R, R R and R Representative compounds provided by this invention include the following:
- the free bases of this invention are oils or low melting solids while their acid addition salts are generally white crystalline solids.
- the free bases are preferably prepared according to the following equation:
- an acetylenic amine (I) is reacted with an alkali-metal base such as sodamide or potassium amide to form the corresponding alkali-metal salt of the acetylene (II).
- This alkali-metal salt is, in turn, reacted with an arylsulfonyl halide such as p-tosyl chloride or p-tosyl bromide to yield the corre sponding amino halo-acetylene (111).
- halogenating agents in particular those which contain a positive halogen'such as N-bromsuccinimide and the hypohalous acids, can be used in place of the arylsulfonyl halide in the above syntheisis to prepare the compounds of this invention.
- the acetylenic amines (I) which are starting materials for the above syntheses can be prepared in a number of ways depending upon the character of the constituent groups R, R R and R
- the method of Hennion and Teach, J. Am. Chem. Soc., 75, 1653 (1953) will furnish the desired primary acetylenic amine.
- the compounds can be prepared by the method of Hennion and Nelson, J. Am. Chem. Soc., 79, 2142 (1947).
- any of R, R R and R is an aromatic radical, the method disclosed in the co-pending application of Nelson R.
- the acid addition salts of the amino haloacetylenes of this invention are readily prepared by methods fully set forth in the prior art. For example, it a solid acid is to be employed in forming the acid addition salt, and equivalent of this acid, either as a solid or in solution, is added to a solution containing an equivalent of the aminoacetylen. If the acid addition salt thus formed is insoluble in the reaction solvent, the salt is isolated by filtration or centrifugation. On the other hand, if the salt is soluble in the reaction medium, it can be isolated as a solid residue by evaporation of the volatile constituents. When a gaseous acid, as for example hydrogen chloride, is employed, it is possible to use an excess of the acid since the excess can be readily removed by volatilization.
- a gaseous acid as for example hydrogen chloride
- acids which form acid addition salts with the amines of this invention are inorganic acids including hydrochloric acid, hydrobromic acid, hydriodic acid, sulphuric acid, phosphoric acid, nitric acid, and the like, as well as organic acids, including acetic acid, tartaric acid, benzoic acid, naphthylensulfonic acid, p-toluenesulfonic acid, succinic acid, maleic acid, 2,4-dinitrobenzoic acid. and the like.
- inorganic acids including hydrochloric acid, hydrobromic acid, hydriodic acid, sulphuric acid, phosphoric acid, nitric acid, and the like
- organic acids including acetic acid, tartaric acid, benzoic acid, naphthylensulfonic acid, p-toluenesulfonic acid, succinic acid, maleic acid, 2,4-dinitrobenzoic acid. and the like.
- the compounds of this invention are useful as chemical intermediates, since they contain two readily modifiable groupsthe acetylenic bond and the reactive halo en atom.
- the acetylenic bond can be hydrated to yield a ketone and the halogen atom can be hydrolyzed to yield a hydroxy group, thus giving a ketol grouping adjacent to an amine function.
- the keto group of the ke-tol can also be reduced, to form an amino 1,2glycol.
- the acetylenic bond can be hydrogenated to give a haloethylene derivative, hydration of which type of compound yields an whale-alcohol containing an amine group beta to the alcohol group.
- the acetylenic bond can also be hydrogenated past the ethylenic bond stage to give a saturated ut-halo-amine, which compound can be cyclized directly to yield an azetidine.
- the a-haloketone produced by the hydration of the acetylenic bond can be cyclized to yield an azetidinone.
- Both the azetidines and azetidinones thus produced have useful pharmaceutical activity as for example as hypotensive agents or as sympatholytic agents.
- the acid addition salts of the amine bases represented by the above formula can be used interchangeably with the base itself in various processes. In addition the acid addition salts are useful in isolating and purifying the amine bases themselves.
- a preferred group of compounds represented by the above formula are those in which R and R represent lower alkyl groups, as for example methyl, ethyl or isopropyl, or when taken together with the carbon atoms to which they are attached represent a cyclohexane ring; in which R represents a lower alkyl group such as ethyl, isopropyl, t-butyl or t-amyl; in which R is either hydrogen or methyl and Hal is chlorine or'bromine.
- R and R represent lower alkyl groups, as for example methyl, ethyl or isopropyl, or when taken together with the carbon atoms to which they are attached represent a cyclohexane ring; in which R represents a lower alkyl group such as ethyl, isopropyl, t-butyl or t-amyl; in which R is either hydrogen or methyl and Hal is chlorine or'bromine.
- These compounds have a very desirable pharmaceutical activity in
- Compounds which demonstrate hypotensive action include 1-chloro-3- t-butylamino-3-methyl-l-butyne, 1-bromo-3-t-butylamino- 3-methyl-1-butyne, N-methyl-N-t-butyl-l-bromo-3-amino- 3-methyl-1-butyne, and l-t-butylamino-l-bromethynylcyclohexane.
- 1-chloro-3-t-butylamino-3-methyl-1-heptyne is an extremely potent sympathomimetic agent.
- reaction mixture was next heated to refluxing temperature for about one hour, thus expelling all of the ammonia and leaving an ethereal suspension of the sodium salt of the acetylene.
- a solution of g. of p-tosyl chloride in 150 ml. of anhydrous ether was added; the resulting mixture was stirred for about two hours and was then allowed to remain at ambient room temperature over night. 200 m1. of water were added to the reaction mixture; the ether layer was separated and dried, and the ether was removed by evaporation in vacuo, leaving as a residue 1-chloro-3-t-butylamino-3-methyl 1 butyne formed in the above reaction.
- EXAMPLE 2 Preparation of N-methyl-N-ethyl-I-br0m0-3- amino-3-methyl-1 -butyne
- About 4 g. of sodium were added in small pieces to 300 ml. of liquid ammonia in the presence of a catalytic quantity of iron chloride, thus forming a suspension of sodamide in liquid ammonia.
- About 13.2 g. of N-methyl- N-ethyl-3-amino3-methyl-l-butyne hydrochloride were added to the sodamide suspension, thus forming the sodium salt of the acetylene with sodium chloride as a byproduct. After stirring the liquid ammonia reaction mixture for one hour, 400 ml.
- the ethereal layer was separated and was extracted with ml. of l N hydrochloric acid, thus causing N-methyl-N- ethyl-l-bromo-3-amino-3-methyl-1-butyne to pass into the aqueous acidic layer as the hydrochloride salt.
- the aqueous acidic layer was made basic by the addition of an excess of 50 percent (w./v.) sodium hydroxide, thus forming N methyl N-ethyl-l-bromo-3-amino-3-methy1-lbutyne free base. The free base was insoluble in the basic aqueous layer and was extracted into ether.
- N methyl N ethyl-1-bromo-3-amino-3-methyl-1- butyne thus prepared was dissolved in 50 ml. of ethanol. An excess of ethanolic hydrogen chloride was added, thus forming N methyl-N-ethyl-l-bromo-3-methyl-l-butyne hydrochloride, which melted at about 196-7 C. after recrystallization from an. ethanol-ether solvent mixture.
- R and R when taken separately, are members of the group consisting of hydrogen, (l -C alkyl, C C alkenyl, lower alkoXy-substituted C -C alkyl, lower alkoxy-substituted C -C alkenyl, cycloalkyl, cycloalkenyl monocyclic and bicyclic aryl, and substituted monocyclic and bicyclic aryl wherein said aryl substituents are members of the group consisting of chlorine, bromine, C -C alkyl, C -C alkenyl, nitro, perfiuoro lower alkyl, perchlorolower alkyl, acetamido, lower alkoXy, and di-lower-alkylamino, and, when taken together with the carbon atom to which they are attached, form a member of the group consisting of cycloalkyl, cycloalkenyl, and monocycl
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Description
United States Patent O 3,172,912 HALOACETYLENIC AMINES Nelson R. Easton and Charles W. Ryan, Indianapolis, Ind., assignors to Eli Lilly and Company, Indianapolis, ind, a corporation of Indiana No Drawing. Filed Nov. 28, 1961, Ser. No. 155,451 7 Qlaims. (61. 269-563) This invention relates to a group of novel halogenated acetylenic amines.
The compounds provided by this invention can be represented by the following formula wherein R and R when taken separately, can be hydrogen, C -C alkyl, C C alkenyl, lower alkoxy-substituted C C alkyl, lower alkoxy substituted C C alkenyl, cycloalkyl, cycloalkenyl, aryl, and substituted aryl, and when taken together with the carbon atoms to which they are attached, can be cycloalkyl, cycloalkenyl, polycyclic aryl, and partially hydrogenated polycyclic aryl; R and R when taken separately, can be hydrogen, C C alkyl, C C alkenyl, cycloalkyl, cycloalkenyl, aryl, substituted aryl and aralkyl, and when taken together with the nitrogen atom to which they are attached, can be morpholino, thiornorpholino, piperidino, pyrrolidino and 4-alkylpiperazino; and Hal is a halogen atom of atomic number greater than 10 such as chlorine, iodine, or bromine. Acid addition salts of the free bases represented by the above formula are also included within the scope of this invention.
When R, R R and R are C -C alkyl radicals, they can be illustratively methyl, ethyl, isopropyl, n-butyl, n amyl, 3-methylpentyl, Z-ethylhexyl, n-decyl, sec-hexyl, isooctyl, 4-ethyloctyl, 6-ethyldecyl, undecyl, 2,3,3-trimethylpentyl, neopentyl and the like; and when they represent C C alkenyl radicals, they can be illustratively allyl, methallyl, crotyl, and the like. Lower alkoXy-substit-uted C C alkyl radicals or lower alkoxy substituted C C alkenyl radicals, which R and R can represent are in general, formed by substituting any of the C -C alkyl or C -C alkenyl radicals illustrated above with an alkoxy group. Illustrative radicals thus formed include methoXyallyl, ethoxyethyl, methoxypropyl, isopropoxydecyl, S-butoxy-Z-pentenyl and the like.
When R, R R and R are aromatic radicals, they can be illustratively phenyl, thienyl, furyl, pyridyl, naphthyl and the like, and permissible substituents in these aromatic rings include halogen, C C alkyl, C alkenyl, nitro, perhaloalkyl, acetarnido, alkoxy, di-alkylamino, and the like. Illustrative substituted aromatic radicals which R, R R and R represent thus include a-bromonaphthyl, Z-chlorophenyl, Z-hydroxyfuryl, indenyl, 2 dimethylaminopyridyl, bromothienyl, tolyl, xylyl, allylphenyl, styryl, trifluoromethylphenyl, pentafluoro-ethylphenyl, trichloromethylphenyl, p-(n-heXyDphenyl, S-ethyl-S-acetylaminopyridyl, nitrothienyl, 3-rnethylfuryl, anisyl, ethoxyphenyl, methoxyfuryl, 3-n-butylphenyl, etc.
The term aromatic is used herein in its conventional sense and includes all radicals having aromatic character. (See for example Chapter 3 of Organic Chemistry, Henry Gilman, editor, 2d edition, John Wiley and Sons, New York, 1943.)
R, R R and R when they repreesnt cycloalkyl radicals or cycloalkenyl radicals, can be illustratively cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclo-octyl, methylcyclopentyl, cyclobutenyl, bicyclo[2.2.l]heptyl, cy-
clopentenyl, cyclohexenyl, and the like.
3,1?2,9l2 Patented Mar. 9, 1965 The groups R and R when taken together with the carbon atom to which they are attached, represent cycloalkyl, cycloalkenyl, polycyclic aryl, and partially hydrogenated polycyclic aryl groups, such as, for example, tetralinyl, indanyl, indenyl, fluorenyl, cyclopentenyl, cyclobutyl, dihydroanthranyl, Xanthyl, Xanthenyl, thioxanthyl, dibenzocycloheptadienyl, dibenzocycloheptatrienyl, cycloheptyl, cyclopentyl, methylcyclopentenyl, cyclohexyl, cycloheptenyl, and the like.
When R and R represent aralkyl radicals, they can be, illustratively, benzyl, phenethyl, 2-phenylpropy1, 1- henylethyl, l-tolylethyl, m-chlorobenzyl, p-anisylrnethyl, homoveratryl and the like, the permissible aryl radicals substituted in the alkyl chain being in general those defined above for R, R R and R Representative compounds provided by this invention include the following:
1-chloro-3-methylamino-3-(o-chlorophenyl) -1-pentadecyne 1-chloro-3-dodecylarnino-3 (Z-bromothienyl -5-methyll-octyne N-ethyl-N- Z-ethoxy ethyll-chloro-3-amino-3-pdimethylaminophenylhex-S-enl-yne N-Z-pyridyl-N-methyll-chloro-3-amino-3-a-naphthyll-decyne l-piperidino- 1- (chloro-ethynyl indane 1-bromo-3-a-pipecolino-3-p-anisyl-4,4-dimethyl-1- pentyne 1-chloro-3- (4-indenylamino) -3-(o-al1yloxyphenyl) lnonyne 5-homoveratrylamino-5- ('chloro-ethynyl xanthene 5- l-chlorophenethylamino) -5- (chloro-ethynyl) l-thioxanthene l-iodo-3-t-butylarnino-3-rnethyl l -butyne 1-bro1no-3 -methylarnino-3-n1ethyll-butyne 1-brorno-3-ethylamino-3-methyl-l-butyne .l-chloro-3 -n-butylamino-3-rnethyl-l-butyne 1-cl1loro-3-morpholino-3-methyl- 1 -butyne 1-bromo-3-piperidino-3-methyl-l-butyne N-rnethyl-N-phenyl-l-chloro-3-amino-3-methyl- 1- butyne 1-chloro-3 -p-anisidino-3 -methyl-1-butyne l-bromo-3-ethylamino-3-methyll-pentyne 1-iodo-3 -isopropylamino-3-methyll-pentyne 1-chloro-3-diethylamino-3-rnethyll-pentyne 1-bromo-3 -anilino-3 -methyl-1-pentyne 1chloro-3-ethylamino-3-ethyll-pentyne 1-chloro-3-anilino-3-ethyll-pentyne 1-etl1yiamino-l-(chloro-ethynyl)cyclohexanc l-anilinol-bromoethynylcyclopentane 1-chloro-3-o-aminoanilino-3-methyll-octyne 1-chloro-3 -o-chloranilino-3-methyll-decyne 1-chloro-3 -m-chloranilino-3-rnethyll-nonyne 1-bromo-3-p-toluidino-3-rnethyl l-heptyne 1-chloro-3-m-nitroanilino-3-methyll-hexyne 1-brorno-3-amino-l-butyne,1-bromo-3-methylaminopropyne l-chloro-3-p-chloranilino-3-rnethyll-butyne N-rnethyl-N- Z-methoxyethyl) -3-amino-3 -methyl- 1- pentyne 1-chloro-3 (2,4-dichloranilino) -3,4-dimethyl-1-pentyne 1-bromo-3- (o-brornanilino -3 ,4,4-trimethyl-1-pentyne N-ethyl-N- 3 ,4-dimethoxyphenyl) l-chloro-3-amino- 3 -rnethy1-1-butyne 1-chloro-3 -rn-ethoxyanilino-3-methyll apentadecyne 1-chloro-3-p-toluidino-3-methyll-pentyne l-bromo-3 -p-acetylamino-anilino-3,5 -dimet l1yll-hexyne 1-chloro-3 -p-trifiuoromethylanilino-3 ,4-dimethyllhexyne 1- p-ethylamino -anilino- 1- (chloro-ethynyl) cyclobutane l-(p-butyenylamino)-anilino-1-(bromo-ethynyl) -3 cyclopentene 1- (4-chlorobenzylamino -lchloro-ethynyl cyclohexane 1- (4-pyrrolidino -anilino- 1- (chloro-ethynyl) cycloheptane 1-bromo-3-p-hydroxyanilino-3 -ethyl-1-hexyne Nmethyl-3- 3,4-dimethylanilino -1-chloro-3 -methyll-butyne 1-bromo-3-p-tolyl-3-benzylamino-l-bu'tyne 1-chloro-3-p-chlorophenyl-3-ethylarnino- 1 -butyne 1-chloro-3-phenyl-3 -n-butylamino-l -hexyne 1-chloro-3-phenyl-3-ethylaminol-nonyne 1-chloro-3-phenyl-3-t-butylamino-l-propyne 1-chloro-3 -allylamino-3-phenyll-butyne 1-bromo-3-phenyl-3-cyclohexylaminol-butyne 1-chloro-3-a1nino-3-phenyl-l-butyne l-bromo-3-ethylamino-3 -,8-naphthyl-1-butyne 1-chloro-3-ethylamino3-phenyl-3-a-thienylpropyne and the like.
The free bases of this invention are oils or low melting solids while their acid addition salts are generally white crystalline solids. The free bases are preferably prepared according to the following equation:
( (III) wherein R, R R R and Hal have the same significance as hereinabove. According to the equation, an acetylenic amine (I) is reacted with an alkali-metal base such as sodamide or potassium amide to form the corresponding alkali-metal salt of the acetylene (II). This alkali-metal salt is, in turn, reacted with an arylsulfonyl halide such as p-tosyl chloride or p-tosyl bromide to yield the corre sponding amino halo-acetylene (111). Other halogenating agents, in particular those which contain a positive halogen'such as N-bromsuccinimide and the hypohalous acids, can be used in place of the arylsulfonyl halide in the above syntheisis to prepare the compounds of this invention.
The acetylenic amines (I) which are starting materials for the above syntheses can be prepared in a number of ways depending upon the character of the constituent groups R, R R and R For example when'R and R are hydrogen and R and R are aliphatic, the method of Hennion and Teach, J. Am. Chem. Soc., 75, 1653 (1953), will furnish the desired primary acetylenic amine. When all of R, R R and R are aliphatic, the compounds can be prepared by the method of Hennion and Nelson, J. Am. Chem. Soc., 79, 2142 (1947). On the other hand, when any of R, R R and R is an aromatic radical, the method disclosed in the co-pending application of Nelson R. Easton and George F. Hennion, Serial No. 138,591, filed September 18, 1961, or the method disclosed in the co-pending application of Nelson R. Easton and Robert D. Dillard, Serial No. 138,585, filed September 18, 1961, can be employed to provide the desired starting material.
The acid addition salts of the amino haloacetylenes of this invention are readily prepared by methods fully set forth in the prior art. For example, it a solid acid is to be employed in forming the acid addition salt, and equivalent of this acid, either as a solid or in solution, is added to a solution containing an equivalent of the aminoacetylen. If the acid addition salt thus formed is insoluble in the reaction solvent, the salt is isolated by filtration or centrifugation. On the other hand, if the salt is soluble in the reaction medium, it can be isolated as a solid residue by evaporation of the volatile constituents. When a gaseous acid, as for example hydrogen chloride, is employed, it is possible to use an excess of the acid since the excess can be readily removed by volatilization.
Among the acids which form acid addition salts with the amines of this invention are inorganic acids including hydrochloric acid, hydrobromic acid, hydriodic acid, sulphuric acid, phosphoric acid, nitric acid, and the like, as well as organic acids, including acetic acid, tartaric acid, benzoic acid, naphthylensulfonic acid, p-toluenesulfonic acid, succinic acid, maleic acid, 2,4-dinitrobenzoic acid. and the like.
The compounds of this invention are useful as chemical intermediates, since they contain two readily modifiable groupsthe acetylenic bond and the reactive halo en atom. For example, the acetylenic bond can be hydrated to yield a ketone and the halogen atom can be hydrolyzed to yield a hydroxy group, thus giving a ketol grouping adjacent to an amine function. The keto group of the ke-tol can also be reduced, to form an amino 1,2glycol. In the same Way, the acetylenic bond can be hydrogenated to give a haloethylene derivative, hydration of which type of compound yields an whale-alcohol containing an amine group beta to the alcohol group. The acetylenic bond can also be hydrogenated past the ethylenic bond stage to give a saturated ut-halo-amine, which compound can be cyclized directly to yield an azetidine. Similarly, the a-haloketone produced by the hydration of the acetylenic bond can be cyclized to yield an azetidinone. Both the azetidines and azetidinones thus produced have useful pharmaceutical activity as for example as hypotensive agents or as sympatholytic agents. The acid addition salts of the amine bases represented by the above formula can be used interchangeably with the base itself in various processes. In addition the acid addition salts are useful in isolating and purifying the amine bases themselves.
The above examples of the utilization of the amino haloacetylene of this invention as intermediates are for the purposes of illustrations only, and it will be apparent to those skilled in the art that many other types of compounds can be prepared by operating upon the acetylenic bond, the acetylenic halogen, or the amine function singly or in combination by processes already illustrated in the prior art, such processes including hydrogenation, hydration hydrolysis, substitution, and the like.
A preferred group of compounds represented by the above formula are those in which R and R represent lower alkyl groups, as for example methyl, ethyl or isopropyl, or when taken together with the carbon atoms to which they are attached represent a cyclohexane ring; in which R represents a lower alkyl group such as ethyl, isopropyl, t-butyl or t-amyl; in which R is either hydrogen or methyl and Hal is chlorine or'bromine. These compounds have a very desirable pharmaceutical activity in that they afiect the central nervous system in desirable ways. Some of the compounds are potent hypotensive agents whereas others are stimulant amines. Compounds which demonstrate hypotensive action include 1-chloro-3- t-butylamino-3-methyl-l-butyne, 1-bromo-3-t-butylamino- 3-methyl-1-butyne, N-methyl-N-t-butyl-l-bromo-3-amino- 3-methyl-1-butyne, and l-t-butylamino-l-bromethynylcyclohexane. 1-chloro-3-t-butylamino-3-methyl-1-heptyne is an extremely potent sympathomimetic agent.
This invention is further illustrated by the following specific examples.
EXAMPLE 1 Preparation of 1-chI0r0-3-t-butylamino-3-methyl-1-butyne A suspension of sodamide in liquid ammonia was prepared by adding 2.59 g. of sodium in small pieces to about 300 ml. of liquid ammonia in the presence of a catalytic quantity of iron chloride. 13.99 g. of 3-t-butylamino-3'- methyll-butyne were added to the sodamide suspension in dropwise fashion, thus forming the sodium salt of the acetylen. The reaction mixture was stirred for about one hour at the end of which time 250 ml. of anhydrous ether Were added. The reaction mixture was next heated to refluxing temperature for about one hour, thus expelling all of the ammonia and leaving an ethereal suspension of the sodium salt of the acetylene. A solution of g. of p-tosyl chloride in 150 ml. of anhydrous ether was added; the resulting mixture was stirred for about two hours and was then allowed to remain at ambient room temperature over night. 200 m1. of water were added to the reaction mixture; the ether layer was separated and dried, and the ether was removed by evaporation in vacuo, leaving as a residue 1-chloro-3-t-butylamino-3-methyl 1 butyne formed in the above reaction. Distillation of the residue through a spinning-band fractionating column yielded purified 1-chloro-3-t-butylamino-3-methyl-l-butyne boiling at about 55 C. at a pressure of about 10 mm. of Hg; 12 1.451.
1-chloro-3-t-butylamino-3-methyl-l-butyne as prepared above was dissolved in anhydrous ether and an excess of an alcoholic hydrogen chloride solution was added to the ethereal solution, thus forming 1-chloro-3-t-butylamino-3- B-methyl-l-butyne hydrochloride which was isolated by filtration and which melted at about 158-9 C. after recrystallization from ethyl acetate.
Analysis.-Calc.: C, 51.43; H, 8.16; N, 6.67. Found: C, 51.93; H, 8.11; N, 6.41.
The following compounds were prepared by chlorinating or brominating the corresponding amino acetylene according to the procedure of Example 1. Their hydrochloride salts were formed as set forth in the same example.
l-chloro-3-t-amylamino-3-methyl-l-butyne. B.P. 55/4 mm. Hg; n =1.455. Hydrochloride salt: M.P. 1234 C. Analysis.-Calc.: Cl, 31.63; N, 6.25. Found: Cl, 31.63; N, 5.97.
1-chloro-3-isopropylamino-3,4-dimethyl-l-pentyne. B.P 53 C./ 5 rmn. Hg; n =1.452. Hydrochloride salt: M.P. 174-6 C. Analysis.--Calc Cl, 31.63; N, 6.25. Found: Cl, 31.39; N, 5.99.
1-chloro-3-t-butylamiuo-3-methyl-l-heptyne. B.P. 83 C./5 mm. Hg; n =1.456. Hydrochloride salt: M.P. 122-4 C. Analysis.-Calc.: Cl, 28.11; N. 5.55. Found: Cl, 28.31; N, 5.45.
l-ethylamino-l-chlorethynylcyclohexane. B.P. 47-51 C./1 mm. Hg; Hydrochloride salt M.P. 2l0-12 C. Analysis.Calc.: Cl, 15.96; N, 6.31. Found: Cl, 16.22; N, 6.20.
N-methyl-N-t-butylamino-1-bromo-3-amino-3-methyl-1- butyne. B.P. 495l C./ 1 mm. Hg; n =1.490. Hydrochloride salt: M.P. 242 C. Analysis.-Calc.: C, 44.70; H, 7.13; N, 5.22. Found: C, 44.78; H, 7.10; N, 5.28.
l-bromo-3-isopropylamino-3-methyl-l-butyne. Hydrochloride salt: M.P. 212214 C. Analysis.Calc.: C, 42.45; H, 6.73; N, 5.50. Found: C, 42.64; H, 6.74; N, 5.71.
1-bromo-3-ethylamino-3-ethyl-l-pentyne: low melting solid which sublimes upon distillation. Hydrochloride salt: M.P. 2l9-2-0 C. Analysis.Calc.: C, 39.94; H, 6.28; N, 5.82. Found: C, 39.97; H, 6.50; N, 5.54.
1-ehloro-3-ethylamino-3-phenyl-l-butyne. B.P. 8894 C./4 mm Hg. Hydrochloride salt: M.P. 1535 C. Analysis.Calc.: C, 59.03; H, 6.19. Found: C, 59.05; H, 6.33.
EXAMPLE 2 Preparation of N-methyl-N-ethyl-I-br0m0-3- amino-3-methyl-1 -butyne About 4 g. of sodium were added in small pieces to 300 ml. of liquid ammonia in the presence of a catalytic quantity of iron chloride, thus forming a suspension of sodamide in liquid ammonia. About 13.2 g. of N-methyl- N-ethyl-3-amino3-methyl-l-butyne hydrochloride were added to the sodamide suspension, thus forming the sodium salt of the acetylene with sodium chloride as a byproduct. After stirring the liquid ammonia reaction mixture for one hour, 400 ml. of ether were added and the reaction mixture was allowed to warm up to ambient room temperature, during which period a major part of the ammonia had evaporated. The ethereal reaction mixture was then heated to refluxing temperature for about one hour to expel the last traces of ammonia. A solution of 19.5 g. of p-tosyl bromide in 200 ml. of anhydrous ether was added to the suspension of the sodium salt of the acetylene, thus forming N-methyl-N-etliyl l bromo-3- amino-3-methyll-butyne. Afterlthe addition of the ptosyl bromide had been completed, the reaction mixture was stirred at refluxing temperature for about one hour and was then cooled. 200 ml. of water were added. The ethereal layer was separated and was extracted with ml. of l N hydrochloric acid, thus causing N-methyl-N- ethyl-l-bromo-3-amino-3-methyl-1-butyne to pass into the aqueous acidic layer as the hydrochloride salt. The aqueous acidic layer was made basic by the addition of an excess of 50 percent (w./v.) sodium hydroxide, thus forming N methyl N-ethyl-l-bromo-3-amino-3-methy1-lbutyne free base. The free base was insoluble in the basic aqueous layer and was extracted into ether. The ethereal layer was separated and dried, and the ether was removed by evaporation in vacuo, leaving N-methyl-N-ethyl-lbromo-3-amino-3-methyl-l-butyne as a crystalline residue.
N methyl N ethyl-1-bromo-3-amino-3-methyl-1- butyne, thus prepared was dissolved in 50 ml. of ethanol. An excess of ethanolic hydrogen chloride was added, thus forming N methyl-N-ethyl-l-bromo-3-methyl-l-butyne hydrochloride, which melted at about 196-7 C. after recrystallization from an. ethanol-ether solvent mixture.
Analysis.-Calc.: N, 5.82; Found: N, 5.53.
The following compounds were prepared by halogenating the corresponding amino acetylene hydrochloride salt as set forth in the above example.
3-amino-1-bromo-3-isopropyl4-methyl 1 pentyne. B.P. 48 C./1 mm. Hg. Hydrochloride salt: sublimed at 225 C. Analysis.-Calc.: C, 42.45; H, 6.73; N, 5.50. Found: C, 42.60; H, 6.62; N, 5.62.
1 ethylamino-1-bromo-ethynylcyclohexane. Hydrochloride salt: M.P. 248 C. Analysis.Calc.: C, 45.04; H, 6.43; N, 5.25. Found: C, 45.56; H, 6.61; N, 5.10.
l-(t-butylamino)-1-chlorethynylcyclohexane. B.P. 61 C./1 mm. Hg; m =1.485. Hydrochloride salt: M.P. 208-10 C. Analysis.Calc.: N, 5.60; Cl, 28.34. Found: N, 5.80; Cl, 28.19.
1-(3-t-butylamino)-1-bromo-ethyny1 cyclohexane. Hydrochloride salt: M.P. 241-2 C. with decomposition. Analysis-Calc.: C, 48.91; H, 7.18; N, 4.75. Found: C, 49.06; H, 7.32; N, 4.81.
EXAMPLE 3 Preparation of 1-br0mo-3-t-buty[amino-.i-methyl- -butyne 27.8 g. of 3-butylamino-3-methyl-l-butyne and 35.8 g. of N-bromosuccinimide were mixed with 250 ml. of carbon tetrachloride. The reaction mixture was heated to refluxing temperature for about fourteen hours, at the end of which time it was cooled and filtered. The carbon tetrachloride was removed by evaporation in vacuo, leaving as a residue 1 -'bromo 3 t butylamino-3-methyl-1- butyne formed in the above reaction. The compound was purified by distillation, and boiled in the range 50-60 C. at a pressure of about 0.5 mm. Hg.
1-bromo-3-t-butylamino-3-methyl-l-butyne prepared as above was dissolved in ethyl acetate and the resulting solution was saturated with gaseous hydrogen chloride, thus forming 1-bromo-3-t-butylamino-3-methyl-l-butyne hydrochloride, which melted at about =183-5 C. after recrystallization from methyl ethyl ketone. Analysis. Calc.: C, 42.45; H, 6.73. Found: C, 42.04; H, 6.82.
We claim:
1. A compound selected from the group consisting of the amino-haloacetylenes represented by the following formula and the acid addition salts thereof:
R-JJ-CEC-Hal wherein R and R when taken separately, are members of the group consisting of hydrogen, (l -C alkyl, C C alkenyl, lower alkoXy-substituted C -C alkyl, lower alkoxy-substituted C -C alkenyl, cycloalkyl, cycloalkenyl monocyclic and bicyclic aryl, and substituted monocyclic and bicyclic aryl wherein said aryl substituents are members of the group consisting of chlorine, bromine, C -C alkyl, C -C alkenyl, nitro, perfiuoro lower alkyl, perchlorolower alkyl, acetamido, lower alkoXy, and di-lower-alkylamino, and, when taken together with the carbon atom to which they are attached, form a member of the group consisting of cycloalkyl, cycloalkenyl, and monocyclic and bicyclic aryl; R and R when taken separately, are members of the group consisting of hydrogen, C -C alkyl, C C alkenyl, cycloalkyl, cycloalkenyl, monocyclic and bicyclic aryl, substituted monocyclic and bicyclic aryl wherein said aryl substitutents are members of the group consisting of chlorine, bromine, C -C alkyl, C C alkenyl, nitro, perfiuoro lower alkyl, perchloro lower alkyl, acetamido, lower alkoxy, di-loweralkylamino, and monocyclic aryl-substituted lower alkyl, and when taken together with the nitrogen atom to which they are attached, form a member of the group consisting of morpholino, thiomorpholino, piperidino, pyrrolidino, and 4-lower alkylpiperazino; and Hal is a halogen atom of atomic number greater than 10.
8 2. A compound represented by the formula all;
Am- -0EG-X all;
References Cited in the file of this patent UNITED STATES PATENTS 2,613,208 Van Hook et al Oct. 7, 1952 2,665,311 McKeever et a1 Jan. 5, 1954 2,901,886 Doerner Sept. 1, 1959 3,007,933 Hennion Nov. 7, 1961 3,067,101 Easton et a1. Dec. 4, 1962 OTHER REFERENCES Truchet: Ann. de Chim., 10th Series, vol. 16, pp. 309- 33s 1931 Marszak-Fleury: Ann. Chim. (Paris), Series 13, vol. 3, pages 656-7l 1 (1958).
Dobson et al.: J. Chem. Soc. (London), volume of 1958, pages 36423647.
Claims (1)
1. A COMPOUND SELECTED FROM THE GROUP CONSISTING OF THE AMINO-HALOACETYLENES REPRESENTED BY THE FOLLOWING FORMULA AND THE ACID ADDITION SALTS THEREOF:
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Cited By (2)
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US4594428A (en) * | 1979-07-06 | 1986-06-10 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Novel substituted heterocyclic amines and methods of preparation thereof |
US5179127A (en) * | 1990-05-24 | 1993-01-12 | Rohm And Haas Company | Halopropargyl acyl compound, compositions, microbicidal uses and processes of preparation |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US2613208A (en) * | 1949-06-29 | 1952-10-07 | Rohm & Haas | Tertiary aminomethylbenzenes |
US2665311A (en) * | 1950-09-23 | 1954-01-05 | Rohm & Haas | Preparation of acetylenic amines |
US2901886A (en) * | 1956-03-21 | 1959-09-01 | Dow Chemical Co | Method of increasing engine thrust |
US3007933A (en) * | 1957-02-27 | 1961-11-07 | Lilly Co Eli | Process for the preparation of secondary and tertiary acetylenic amines |
US3067101A (en) * | 1959-11-25 | 1962-12-04 | Lilly Co Eli | Method for controlling hypertension |
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0
- US US3172912D patent/US3172912A/en not_active Expired - Lifetime
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2613208A (en) * | 1949-06-29 | 1952-10-07 | Rohm & Haas | Tertiary aminomethylbenzenes |
US2665311A (en) * | 1950-09-23 | 1954-01-05 | Rohm & Haas | Preparation of acetylenic amines |
US2901886A (en) * | 1956-03-21 | 1959-09-01 | Dow Chemical Co | Method of increasing engine thrust |
US3007933A (en) * | 1957-02-27 | 1961-11-07 | Lilly Co Eli | Process for the preparation of secondary and tertiary acetylenic amines |
US3067101A (en) * | 1959-11-25 | 1962-12-04 | Lilly Co Eli | Method for controlling hypertension |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4594428A (en) * | 1979-07-06 | 1986-06-10 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | Novel substituted heterocyclic amines and methods of preparation thereof |
US5179127A (en) * | 1990-05-24 | 1993-01-12 | Rohm And Haas Company | Halopropargyl acyl compound, compositions, microbicidal uses and processes of preparation |
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