US3013048A - Isocy anato substituted aryl phosphorus esters - Google Patents

Isocy anato substituted aryl phosphorus esters Download PDF

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US3013048A
US3013048A US789810A US78981059A US3013048A US 3013048 A US3013048 A US 3013048A US 789810 A US789810 A US 789810A US 78981059 A US78981059 A US 78981059A US 3013048 A US3013048 A US 3013048A
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isocyanato
aryl
phosphoric acid
acid
phenyl
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Holtschmidt Hans
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/77—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur
    • C08G18/776—Polyisocyanates or polyisothiocyanates having heteroatoms in addition to the isocyanate or isothiocyanate nitrogen and oxygen or sulfur phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/18—Esters of thiophosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/242—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/71—Monoisocyanates or monoisothiocyanates
    • C08G18/717—Monoisocyanates or monoisothiocyanates containing phosphorus

Definitions

  • R and R" may represent radicals 4,4',4"-triisocyanatophenyl dithiophosphate of polyhydric alcohols, such as, for example, ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol and the p H 10 like, polyvalent amines, such as, for example, N,N-di- OCN S [OC NCO] methyl ethylene diamine, N,N-diethyl-1,3-propylene di- 2 amine, N,N-dimethyl-1,3-phenylene diamine, and the like,
  • polyhydric alcohols such as, for example, ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol and the p H 10 like
  • polyvalent amines such as, for example, N,N-di- OCN S [OC NCO] methyl ethylene diamine, N,N-diethyl-1,3-propylene di- 2 amine, N,N-dimethyl-1,
  • linear or branched polyesters such as, for example, the reaction product of succinic acid with trimethylol propane 4,4,4"-triisocyanatophenyl tetrath-iophosphate s or ethylene glycol, and the like, polyethers, such as, for example,
  • 1i 1 example, those obtained from the condensation of alkylene oxides and compounds such as diethylene glycol, poly- 4-isocyanat0, 6-chlorophenyl diethyl phosphoric a id L anudes, polyester amides, such as, for example, the reaction product of succinic acid with amino alcohols and more particularly l-amino, Z-hydroxy ethylene and the Cl 0 like and polythioethers, such as, for example, thioglycols OCNOO% (OCZH5)Z and more particularly thiodig lycol which link two or more phosphoric acid or thlophosphoric ac1d nuclei through oxygen, sulfur and/or nitrogen atoms.
  • alkylene oxides and compounds such as diethylene glycol, poly- 4-isocyanat0, 6-chlorophenyl diethyl phosphoric a id L anudes
  • polyester amides such as, for example, the reaction product of succinic acid with amino alcohols and more particularly
  • Repre- 4isocyanato, fi-chlorophenyl diethyl thiophosphoric acid sentative compounds of this type contemplated by the triester invention are, for example, those having the following formulae: Cl s o 0 ester NCO 4,4',4"-triisocyanato benzyl dithiophosphate
  • the new isocyanates are prepared by phosgenating the corresponding amino aryl phosphoric acid derivatives.
  • the amino aryl phosphoric acid derivatives may be pre- OCNOCH -SP- 0-0Hz" NOO] pared by nitration followed by reduction or the corre- 2 sponding phosphoric acid and thiophosphoric esters, thiO- 1 esters and amides, such as, for example, triphenyl phosphate, tricresyl phosphate, triphenyl thiophosphate, triphenyl phosphor-amide and the like.
  • amino Phenylphosphoric acid ester bis N,N-4-isocyanato pheny process of this invention to prepare the new aromatic iso- O derivatives which are phosgenated in accordance with the C 0i N/ cyauates-may be prepared by the reaction of phosphoric 1 acid chlorides or substituted phosphoric acid chlorides v 2 with nitrophenols and the like, such as, for example, nitro v henzyl alcohol, nitro naphthol and nitro methylphenol pheny! Phosphor? acid ester bls followed by reduction to the corresponding amines.
  • the remainder of the amino-compound is obtained by precipitation with water, whereby about another 210 g. crystallize out, so that the total yield is about 315 g. (85% of the theoretical).
  • the substance is obtained in an analytically pure form having sharp melting point. It can be recrystallized from alcohol and is completely soluble in hydrochloric acid and has a melting point of 155 C.
  • Example 2 About 195 g. of p-nitrophenyl-thiophosphoric acidtriester, prepared from nitrophenol sodium plus PSCl in xylene (MP. 181 C.183 C.) are dissolved in 1.2 liters of methanol and, after adding about 30 g. of Raney nickel, are hydrogenated at a temperature of about 50 75 C. and at a hydrogen pressure of about -40 atm. The absorption of hydrogen is complete after two hours. After filtering, the main quantity of the p-aminophenylthiophosphoric acid-trimester crystallizes out from the methanol, and the remainder can be obtained by precipitation with Water. Yield: 152 g. (97.5% of the theoretical), M.P. 156 C.
  • Example3 About 95 g. of diethyl-p-nitrophenyl-thiophosphoric acid-triester, dissolved in about 300 cc. of methanol, are hydrogenated in the presence of about g. of Raney nickel at between about 50 and about 60 C. and under a hydrogen pressure of about 20-40 atm. The hydrogen absorption is complete after three hours. Thereafter the solid material is filtered oil from the catalyst and the methanol solution is concentrated. The residue is a reddish-yellow oil which is completely soluble in 10% hydrochloric acid. Yield: 86 g.
  • Example 4 About 302 g. of p-nitrophenyl-phosphoric acid-diester dirnethylamide (prepared from N-dimethylamino-phosphoric acid dichloride and nitrophenol sodium, M.P. 148 C.) are hydrogenated in about 1.2 liters of methanol at about 60 C.75 C. after the addition of about g. of Raney nickel. The hydrogenation is complete after three hours; the solid material is filtered oil from the catalyst and the filtrate is concentrated. A light yellow oil which crystallizes on stirring with methylene chloride is left. Yield: 258 g., ⁇ /i.P. 101 C.103 C. (with decomposition).
  • Example 5 About 268 g. of p-nitrophenyl-phosphoric acid-diester methyl phenylamide (prepared according to Example 4) are hydrogenated and worked up as in Example 4. Yield: 220 g., MP. 110 C.-111 C.
  • amino compounds used as starting materials in the process of this invention are more particularly disclosed in copending application S.N. 790,034.
  • amino aryl phosphoric acid derivatives or amino aryl thiophosphoric acid derivatives are converted to the corresponding isocyanates by phosgenation.
  • Any suitable phosgenation method may be used, such as, for example, the cold phase-hot phase phosgenation or even according to the hydrochloride process, the corresponding amine hydrochloride being phosgenated.
  • a suitable phosgenation process is disclosed in US. Patent 2,680,127. The process can be carried out either continuously or intermittently.
  • an inert solvent such as, toluene, benzene, xylylene, trichloro ethylene, chlorobenzene, o-dichloro benzene.
  • the temperature for the phosgenation reaction is not critical. However, it is preferable not to choose too high a temperature for the phosgenation. For this reason, the cold phase-hot phase phosgenation is preferred to the hydrochloride process. In the cold phase-hot phase phosgenation, the mixture of carbamic acid chloride and amine hydrochloride occurs in such a fine suspension that the hot phase phosgenation is completed in a short time. Temperatures between about C. and about 120 C. are preferred in the final phase of the phosgenation, although higher and lower temperatures may be used, if desired.
  • Recrystallization or distillation of the isocyanates prepared according to the process of this invention is not necessary in most cases, since the products are obtained in a relatively pure form. However, any carbamic acid chloride which may still be present should be destroyed. The excess phosgene may be adequately removed by heating the reaction mixture for a short time at reduced pressure below the boiling point or by blowing an inert gas through the reaction mixture at an elevated temperature.
  • Example 6 About 1.5 liters of substantially anhydrous 'chlorobenzone are placed in a three-liter flask, cooled to about 10 C. and thereafter about 800 g. of phosgene are introduced and condensed. At the same temperature about 371 g. of finely powdered 4,4,4"-triamino-triphenyl phosphate are added in portions. The mixture is stirred for about four hours in the cold and'then left overnight at room temperature. Thereafter, a powerful stream of phosgene is introduced at a temperature of between about C. and about C. until a homogeneous solution is present. The chlorobenzene solution is then blown out with nitrogen and the chlorobenzene distilled off in vacuo. The residue isthereafter treated for approximately another hour at about C. under high vacuum in order to destroy remaining traces of carbamic acid chloride.
  • the yellow oil which remains is 4,4',4"-triisocyanato-;
  • Example 7 chlorobenzene and the mixture is left standing overnight in the cold. The temperature is thereafter raised with further introduction of phosgene. After about 6 hours, at a phosgenation temperature of about 100 C. to about 110 C. everything dissolves except for a slight slimy residue, which is filtered otf following the addition of substantially anhydrous active carbon. A lightyellow melt, 4,4',4"-triisocyanato phenyl thiophosphate, is left, which soon solidifies into crystalline form. Yield 380 g. (82% of the theoretical), M.P. 84 C.86 C.
  • Example 8 About 700 g. of phosgene are liquified in about 1.5 liters of chlorobenzene at about -10 C. Thereafter, a solution of about 475 g. of diethyl mono-p-aminophenyl-thiophosphoric acid-triester, dissolved in about 1 liter of chlorobenzene, is added dropwise so that the temperature does not rise higher than about C. After standing in the cold overnight, mo-re phosgene is introduced at about 100 C. to about 110 C. A light clear solution has formed after about 4 hours. This is worked up as in Example 2. About 472 g. of the slightly brownish oily isocyanate are obtained as residue. B.P.: 147 C.149 C. (with slight decomposition).
  • Example 9 About 220 g. of (p-aminophenyl)-phosphoric-di-estermono-methyl phenylarnide are introduced at about 0 C. to a solution of about 500 g. of pliosgene in about 2 liters of chlorobenzene. After standing in the cold overnight, the reaction mixture has solidified to a pasty mass which becomes liquid again at about 80 C. More phosgene is introduced for about 4 hours at about 100 to about 110 C. The isocyanate remaining, after distilling off the chlorobenzene, is a light brownish non-.
  • the process of the invention may be used to produce monoisocyanates, diisocyanates, triisocyanates or higher polyisocyanates.
  • the monoisocyanates and polyisocyanates obtainable by the process of the present invention are useful as starting materials for the manufacture of polyurethane plastics. They may be polymerized by the well-known isocyanate polyaddition process to prepare cellular polyurethanes or homogeneous polyurethanes having improved flame resistance. Coatings produced from the isocyanates of the present invention may be used to replace oil base paint for coating metals or other substrates.
  • Isocyanato phosphorous compounds having the formula wherein X is selected from the group consisting of oxygen and sulfur, R is selected from the group consisting of O-aryl, O-aralkyl, O-alkaryl, O-cycloalkaryl, S-aryl, S-aralkyl, S-alkaryl, S-cycloalkaryl, N-(aryl) N-(alkyl)(aryl), N-(alkaryl) N(aralkyl) and N(cycloalkaryl) R and R" are selected from the group consisting of R, O-alkyl, O-cycloalkyl, S-alkyl, S-cycloalkyl, N-(alkyl) and N-(cycloalkyh at least one of the aryl radicals having at least one isocyanato group bonded to a carbon atom of the aromatic ring.
  • Isocyanato phosphorous compounds having the formula II/ R-P wherein X is selected from the group consisting of oxygen and sulfur and R is O-aryl, at least one of the aryl radicals having at least one isocyanato group bonded to,
  • Isocyanato phosphorous compounds having the formula wherein X is selected from the group consisting of oxygen and sulfur, R and R are O-aryl and R is N-(alkyl)- (aryl), at least one of the aryl radicals having at least one isocyanato group bonded to a carbon atom of the aromatic ring.
  • Isocyanato phosphorous compounds having the formula X R M wherein X is selected from the group consisting of oxygen and sulfur, R is O-aryl and R and R" are O-alkyl, said aryl radical having at least one isocyanato group bonded to a carbon atom of the aromatic ring.
  • a process for the preparation of triisocyanato phen- 1% yl phosphate which comprises reacting a triarnino phenyl phosphate with phosgene.
  • a process for the preparation of triisocyanato phenyl thiophosphate which comprises reacting a triarnino phenyi thiophos-phate with phosgene.

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Description

United States T" atent Q1 3,013,048 ISOCYANATO SUBSTITUTED ARYL PHOSPHORUS ESTERS Hans Holtschmidt, Koln-Stammheini, Germany, assignor to Farbenfabriken Bayer Aktiengesellschaft, Leverkusen, Germany, a corporation of Germany N Drawing. Fiied Jan. 29, 1959, Ser. No. 789,810 Claims priority, application Germany Get. 20, 1958 14 Claims. (Cl. 260-461) This invention relates to aromatic isocyanates and more particularly to isocyanato aromatic esters, thioesters and amide derivatives of phosphoric acid and thiophosphoric acids.
It is an object of this invention to provide isocyanato aromatic phosphoric acid and thiophosphoric acid derivatives. Another object of this invention is to provide isocyanato aromatic phosphoric acid and thiophosphoric acid derivatives which may be used to prepare urethanes having improved flame resistance. Still another object of this invention is to provide a process for the preparation of aryl isocyanato phosphoric acid and thiophosphoric acid derivatives.
These objects and others, which will become obvious from the following disclosure, are accomplished, in accordance with the invention, generally speaking, by providing isocyanato aryl derivatives of phosphoric acids. Thus, this invention contemplates isocyanato aryl phosphorous esters, thioesters and amides having the formula 4,4',4",-triisocyanat0 phenyl phosphate I! -t Q 4,4',4-triisocyanato phenyl thiophosphate 4,4',4"-triisocyanato ben'zyl phosphate 4,4',4-triisocyanato benzyl thiophosphate i i 'P-[o-cmQzroo] I i 3 Diethy1-4-isocyanatophenyl phosphoric acid triester [HsCzOh-P-OQNCO Diethyl-4-isocyanatopheny1 thiophosphonic acid triester [HsCaOlz-P-OONCO Cyclopentadieny1-4-isocyanatophenyl phosphoric acid triester, dimethyl amide Cyclopentadienyl-4-isocyanatophenyl thiophosphoric acid diester dimethyl amide Ethyl, vinyl, 4-isocyanato naphthyl phosphoric acid tri-v ester 4 NCO Ethyl, vinyl, 4-isocyanato naphthyl thiophosphoric acid triester NCO' Ethyl phosphoric acid ester-bis (N-methyl-N-4-isocyanato- Ethyl thiopho sphoric acid ester-bis (N-methyl-N-4-isocyanatophenyl amide) f (3-isocyanato-5-methyl phenyl) phosphoric acid triester (3-isocyanato-5-methyl phenyl) thiophosphoric. acid triester t rte-$9 amide) 4 (3-isocyanato 5 methyl phenyl) dithiophosphoric acid ester, such as, carbomethoxy, carboethoxy and carbotriester. i butoxy, and unsaturated hydrocarbon, such as, vinyl, allyl and butenyl, in addition to the ispcyanato group which is CH3 i NCO attached to a carbon atom of an aromatic ring. Further, C SP 0G compounds containing more than one phosphoric acid or NCO CH3 7 0 thiophosphoric acid nucleus are contemplated by the invention. In such cases R and R" may represent radicals 4,4',4"-triisocyanatophenyl dithiophosphate of polyhydric alcohols, such as, for example, ethylene glycol, 1,3-propylene glycol, 1,4-butylene glycol and the p H 10 like, polyvalent amines, such as, for example, N,N-di- OCN S [OC NCO] methyl ethylene diamine, N,N-diethyl-1,3-propylene di- 2 amine, N,N-dimethyl-1,3-phenylene diamine, and the like,
linear or branched polyesters, such as, for example, the reaction product of succinic acid with trimethylol propane 4,4,4"-triisocyanatophenyl tetrath-iophosphate s or ethylene glycol, and the like, polyethers,,such as, for
1i: 1 example, those obtained from the condensation of alkylene oxides and compounds such as diethylene glycol, poly- 4-isocyanat0, 6-chlorophenyl diethyl phosphoric a id L anudes, polyester amides, such as, for example, the reaction product of succinic acid with amino alcohols and more particularly l-amino, Z-hydroxy ethylene and the Cl 0 like and polythioethers, such as, for example, thioglycols OCNOO% (OCZH5)Z and more particularly thiodig lycol which link two or more phosphoric acid or thlophosphoric ac1d nuclei through oxygen, sulfur and/or nitrogen atoms. Repre- 4isocyanato, fi-chlorophenyl diethyl thiophosphoric acid sentative compounds of this type contemplated by the triester invention are, for example, those having the following formulae: Cl s o 0 ester NCO 4,4',4"-triisocyanato benzyl dithiophosphate The new isocyanates are prepared by phosgenating the corresponding amino aryl phosphoric acid derivatives. 7 The amino aryl phosphoric acid derivatives may be pre- OCNOCH -SP- 0-0Hz" NOO] pared by nitration followed by reduction or the corre- 2 sponding phosphoric acid and thiophosphoric esters, thiO- 1 esters and amides, such as, for example, triphenyl phosphate, tricresyl phosphate, triphenyl thiophosphate, triphenyl phosphor-amide and the like. Further, the amino Phenylphosphoric acid ester bis (N,N-4-isocyanato pheny process of this invention to prepare the new aromatic iso- O derivatives which are phosgenated in accordance with the C 0i N/ cyauates-may be prepared by the reaction of phosphoric 1 acid chlorides or substituted phosphoric acid chlorides v 2 with nitrophenols and the like, such as, for example, nitro v henzyl alcohol, nitro naphthol and nitro methylphenol pheny! Phosphor? acid ester bls followed by reduction to the corresponding amines. The methyl Phenyl nude) following examples illustrate the preparation of reprer 2 V N 0 seutative amino aromatic phosphoric acid and thiophos- I phoric acid derivatives which may be phosgenated in accordance with the process of the present invention.
NCO About 461 g. (1 mol) of p-nitrophenyl-phosphoric acid-triester, prepared by nitration of triphenyl phosphate in nitric acid (density 1.51) at about 5 C, to about (358 0 C. are dissolved in about 3000 cc. of methanol and introduced into a 7-liter stirrer-type autoclave after adding about 25 g. of fresh Raney nickel. The reduction is completed after about 2-3 hours at a temperature of about 50 C. and a hydrogen pressure betweenabout 20 p v V l1 and about 40 atm. a Q NO 1 In working up the product, the reaction mixture is filtered while heating, from the hydrogenation catalyst Phenyl phosphoric acid diester, N,N-4-isocyanato benzyl amide The substituents in the, above-mentioned formula may and the filtrate is cooled with ice. About 105 g. of the also contain further subsutuents, such as, for example, paminophenyl-phosphoric acid-triester are. crystallized halogen, such as chlorine, iodine and bromine; alkoxy, out in the form of small needles. After filtering with such as, methoxy, ethoxy and propoxy; carboxylic acid suction, the remainder of the amino-compound is obtained by precipitation with water, whereby about another 210 g. crystallize out, so that the total yield is about 315 g. (85% of the theoretical). In this way the substance is obtained in an analytically pure form having sharp melting point. It can be recrystallized from alcohol and is completely soluble in hydrochloric acid and has a melting point of 155 C.
Analysis-Calculated: C, 58.3%; H, 4.86%; N, 11.31%; P, 8.36%. Found: C, 58.13%; H, 5.0%; N 11.40%; P, 8.5%.
Example 2 About 195 g. of p-nitrophenyl-thiophosphoric acidtriester, prepared from nitrophenol sodium plus PSCl in xylene (MP. 181 C.183 C.) are dissolved in 1.2 liters of methanol and, after adding about 30 g. of Raney nickel, are hydrogenated at a temperature of about 50 75 C. and at a hydrogen pressure of about -40 atm. The absorption of hydrogen is complete after two hours. After filtering, the main quantity of the p-aminophenylthiophosphoric acid-trimester crystallizes out from the methanol, and the remainder can be obtained by precipitation with Water. Yield: 152 g. (97.5% of the theoretical), M.P. 156 C.
Analysis-Calculated for C H O N PS: C: 56.0%,
H=4.6%, N=10.8%, S== 8.2%, P=8.0%. Found: C=55.6%, H=4.9%, N=10.8%, S=8.2%, P=8.2%. Example3 About 95 g. of diethyl-p-nitrophenyl-thiophosphoric acid-triester, dissolved in about 300 cc. of methanol, are hydrogenated in the presence of about g. of Raney nickel at between about 50 and about 60 C. and under a hydrogen pressure of about 20-40 atm. The hydrogen absorption is complete after three hours. Thereafter the solid material is filtered oil from the catalyst and the methanol solution is concentrated. The residue is a reddish-yellow oil which is completely soluble in 10% hydrochloric acid. Yield: 86 g.
Analysis. C a l c u l a t e d: N=5.7%, S=13.0%, P=l2.0%. Found: N=5.56%, S=12.0%, P=12.6%.
Analysis of the phenyl urea (M.P. 108 C.): Calculated N=7.7%, S=8.8%, P=8.5%. Found N=7.8%, S=8.3%, P=-8.5.%.
Example 4 About 302 g. of p-nitrophenyl-phosphoric acid-diester dirnethylamide (prepared from N-dimethylamino-phosphoric acid dichloride and nitrophenol sodium, M.P. 148 C.) are hydrogenated in about 1.2 liters of methanol at about 60 C.75 C. after the addition of about g. of Raney nickel. The hydrogenation is complete after three hours; the solid material is filtered oil from the catalyst and the filtrate is concentrated. A light yellow oil which crystallizes on stirring with methylene chloride is left. Yield: 258 g., \/i.P. 101 C.103 C. (with decomposition).
Analysis. C al cu l at e d: C=54.6%, H=5.8%, N=13.7%, P=10.1%. Found: C=54.6%, H=5.8%, N=14.2%, P=10.1%.
Example 5 About 268 g. of p-nitrophenyl-phosphoric acid-diester methyl phenylamide (prepared according to Example 4) are hydrogenated and worked up as in Example 4. Yield: 220 g., MP. 110 C.-111 C.
Analysis. C a l c 111 ate d: C=61.9%, H=5.4%, N=11.4%, P=8.4%. Found: C=61.9%, H=5.7%, N=11.7%, P=8.5%.
The amino compounds used as starting materials in the process of this invention are more particularly disclosed in copending application S.N. 790,034.
According to the process of the invention, amino aryl phosphoric acid derivatives or amino aryl thiophosphoric acid derivatives are converted to the corresponding isocyanates by phosgenation. Any suitable phosgenation method may be used, such as, for example, the cold phase-hot phase phosgenation or even according to the hydrochloride process, the corresponding amine hydrochloride being phosgenated. A suitable phosgenation process is disclosed in US. Patent 2,680,127. The process can be carried out either continuously or intermittently. Advantageously, one employs an inert solvent, such as, toluene, benzene, xylylene, trichloro ethylene, chlorobenzene, o-dichloro benzene.
The temperature for the phosgenation reaction is not critical. However, it is preferable not to choose too high a temperature for the phosgenation. For this reason, the cold phase-hot phase phosgenation is preferred to the hydrochloride process. In the cold phase-hot phase phosgenation, the mixture of carbamic acid chloride and amine hydrochloride occurs in such a fine suspension that the hot phase phosgenation is completed in a short time. Temperatures between about C. and about 120 C. are preferred in the final phase of the phosgenation, although higher and lower temperatures may be used, if desired.
Recrystallization or distillation of the isocyanates prepared according to the process of this invention is not necessary in most cases, since the products are obtained in a relatively pure form. However, any carbamic acid chloride which may still be present should be destroyed. The excess phosgene may be adequately removed by heating the reaction mixture for a short time at reduced pressure below the boiling point or by blowing an inert gas through the reaction mixture at an elevated temperature.
It was not to be expected that the phosgenation of the amino aryl phosphoric acid ester derivatives and the like would proceed without cleavage of the ester, thioester or amide bonds. However, the process of the invention proceeds in a surprisingly simple and convenient manner. The isocyanato aryl phosphoric acid derivatives are obtained in unexpectedly high yields usually exceeding 80% of the theoretical. The formation of acid chlorides which would be expected from the reaction of phosgene does not take place. Further, the acid chlorides do not appear as secondary products even in small quantities.
In order to better describe and further classify the invention, the following are specific embodiments.
Example 6 About 1.5 liters of substantially anhydrous 'chlorobenzone are placed in a three-liter flask, cooled to about 10 C. and thereafter about 800 g. of phosgene are introduced and condensed. At the same temperature about 371 g. of finely powdered 4,4,4"-triamino-triphenyl phosphate are added in portions. The mixture is stirred for about four hours in the cold and'then left overnight at room temperature. Thereafter, a powerful stream of phosgene is introduced at a temperature of between about C. and about C. until a homogeneous solution is present. The chlorobenzene solution is then blown out with nitrogen and the chlorobenzene distilled off in vacuo. The residue isthereafter treated for approximately another hour at about C. under high vacuum in order to destroy remaining traces of carbamic acid chloride.
The yellow oil which remains is 4,4',4"-triisocyanato-;
phenyl phosphate. It crystallizes after a few days as an analytically-pure white .waxy mass. Yield: 380 g. (85% of the theoretical).
Analysis-Calculated: c, 56.1%; H, 2.68%; N, 9.36%;
P, 6.91%; NCO, 28.1%. Found: C, 55.74%; H, 2.60%; N, 9.70%; P, 6.95%'; NCO, 28.3%.
Example 7 chlorobenzene and the mixture is left standing overnight in the cold. The temperature is thereafter raised with further introduction of phosgene. After about 6 hours, at a phosgenation temperature of about 100 C. to about 110 C. everything dissolves except for a slight slimy residue, which is filtered otf following the addition of substantially anhydrous active carbon. A lightyellow melt, 4,4',4"-triisocyanato phenyl thiophosphate, is left, which soon solidifies into crystalline form. Yield 380 g. (82% of the theoretical), M.P. 84 C.86 C.
Analysis.Calculated: C=54.l%, l-I=2.6%, N: 9.05%, P=6.7%, S=6.9%. Found: C=53.9%, H: 2.8%, N=9.1%, P=6.9%, S=7.3%.
Example 8 About 700 g. of phosgene are liquified in about 1.5 liters of chlorobenzene at about -10 C. Thereafter, a solution of about 475 g. of diethyl mono-p-aminophenyl-thiophosphoric acid-triester, dissolved in about 1 liter of chlorobenzene, is added dropwise so that the temperature does not rise higher than about C. After standing in the cold overnight, mo-re phosgene is introduced at about 100 C. to about 110 C. A light clear solution has formed after about 4 hours. This is worked up as in Example 2. About 472 g. of the slightly brownish oily isocyanate are obtained as residue. B.P.: 147 C.149 C. (with slight decomposition).
Analysis-Calculated: N=5.2%, P=l1.4%, 11.8%. Found: N=5.3%, P=ll.0%, S=11.0%.
Example 9 About 220 g. of (p-aminophenyl)-phosphoric-di-estermono-methyl phenylarnide are introduced at about 0 C. to a solution of about 500 g. of pliosgene in about 2 liters of chlorobenzene. After standing in the cold overnight, the reaction mixture has solidified to a pasty mass which becomes liquid again at about 80 C. More phosgene is introduced for about 4 hours at about 100 to about 110 C. The isocyanate remaining, after distilling off the chlorobenzene, is a light brownish non-.
crystallizing oil. Yield: 220 g.
-Analysis.Calculated: C=59.8%, H=3.8%, N: 10.2%,, P=7.5%. Found: C=59.9%, H=3.8%, N: 10.0%, P=7.4%.
Although only some of the aforementioned. isocyanato aryl phosphoric acid and thiophosphoric acid derivatives were prepared in the foregoing examples, it is to be understood that any of the class of phosphoric acid derivatives more fully disclosed above can be prepared in a similar manner. Further, any of the corresponding amino compounds, more fully disclosed above can be phosgenated in accordance with the process disclosed by the examples to produce the cor-responding isocyanato aryl phosphoric acid derivatives.
It is obvious that the process of the invention may be used to produce monoisocyanates, diisocyanates, triisocyanates or higher polyisocyanates. The monoisocyanates and polyisocyanates obtainable by the process of the present invention are useful as starting materials for the manufacture of polyurethane plastics. They may be polymerized by the well-known isocyanate polyaddition process to prepare cellular polyurethanes or homogeneous polyurethanes having improved flame resistance. Coatings produced from the isocyanates of the present invention may be used to replace oil base paint for coating metals or other substrates.
Although the invention has been described in considerable detail in the foregoing for the purpose of illustration, it is to be understood that such detail is solely for this purpose and that variations can be made therein by those skilled in the art without departing from the spirit and scope of the invention except as is set forth in the claims.
8 What is claimed is: 1. Isocyanato phosphorous compounds having the formula wherein X is selected from the group consisting of oxygen and sulfur, R is selected from the group consisting of O-aryl, O-aralkyl, O-alkaryl, O-cycloalkaryl, S-aryl, S-aralkyl, S-alkaryl, S-cycloalkaryl, N-(aryl) N-(alkyl)(aryl), N-(alkaryl) N(aralkyl) and N(cycloalkaryl) R and R" are selected from the group consisting of R, O-alkyl, O-cycloalkyl, S-alkyl, S-cycloalkyl, N-(alkyl) and N-(cycloalkyh at least one of the aryl radicals having at least one isocyanato group bonded to a carbon atom of the aromatic ring.
2. 4,4,4"-triisocyanato phenyl phosphate.
3. 4,4,4-triisocyanato phenyl thiophosphate.
4. Diethyl mono-p-isocyanato phenyl thiophosphoric acid triester.
5. (p-Isocyanato phenyl)-phosphoric-diester -monomethyl phenyl amide.
6. A process for the preparation of isocyanato phosphorous compounds having the formula wherein X is selected from the group consisting of oxygen and sulfur, R is O-aryl and R and R" are selected from the group consisting of R, O-alkyl, O-cycloalkyl, S-allryl, S-cycloalkyl, N-(alkyl) and N-(cyclo-alkyh at least one of the aryl radicals having at least one isocyanato group bonded to a carbon atom of the aromatic ring.
8. Isocyanato phosphorous compounds having the formula II/ R-P wherein X is selected from the group consisting of oxygen and sulfur and R is O-aryl, at least one of the aryl radicals having at least one isocyanato group bonded to,
'a carbon atom of the aromatic ring.
9'. Isocyanato phosphorous compounds having the formula wherein X is selected from the group consisting of oxygen and sulfur, R and R are O-aryl and R is N-(alkyl)- (aryl), at least one of the aryl radicals having at least one isocyanato group bonded to a carbon atom of the aromatic ring.
10. Isocyanato phosphorous compounds having the formula X R M wherein X is selected from the group consisting of oxygen and sulfur, R is O-aryl and R and R" are O-alkyl, said aryl radical having at least one isocyanato group bonded to a carbon atom of the aromatic ring.
11. A process for the preparation of triisocyanato phen- 1% yl phosphate which comprises reacting a triarnino phenyl phosphate with phosgene.
12. A process for the preparation of triisocyanato phenyl thiophosphate which comprises reacting a triarnino phenyi thiophos-phate with phosgene.
13. Triisocyanato phenyl phosphates.
14. Tiiisocyanato phenyl thiophosphate.
References Cited in the file of this patent UNITED STATES PATENTS 2,691,567 Kvalnes et a1. Oct. 12, 1954

Claims (2)

1. ISOCYANATO PHOSPHORUS COMPOUNDS HAVING THE FORMULA
11. A PROCESS FOR THE PREPARATION OF TRIISOCYANATO PHENPHOPHATE WITH PHOSGENE.
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3100790A (en) * 1960-03-12 1963-08-13 Bayer Ag Isocyanoaryl esters of phosphonic, phosphinic, thiophosphonic, and thiophosphinic acids
US3113146A (en) * 1960-05-09 1963-12-03 Ici Ltd Isocyanates containing silicon
US3240726A (en) * 1960-08-25 1966-03-15 Bayer Ag Polyurethanes prepared from isocyanato phosphorus compounds
US3277211A (en) * 1962-08-10 1966-10-04 Hooker Chemical Corp Pentahalocyclopentadienylsubstituted phosphates
US3277212A (en) * 1961-05-25 1966-10-04 Bayer Ag Phosphorous containing isocyanates
US3341463A (en) * 1964-11-16 1967-09-12 Mobay Chemical Corp Organic polyisocyanates
US20100086860A1 (en) * 2008-10-01 2010-04-08 Bayer Materialscience Ag Photopolymer compositions for optical elements and visual displays

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2691567A (en) * 1951-10-23 1954-10-12 Du Pont Polymeric organic phosphorus compounds for increasing flame resistance of textiles and method of using same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2691567A (en) * 1951-10-23 1954-10-12 Du Pont Polymeric organic phosphorus compounds for increasing flame resistance of textiles and method of using same

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3100790A (en) * 1960-03-12 1963-08-13 Bayer Ag Isocyanoaryl esters of phosphonic, phosphinic, thiophosphonic, and thiophosphinic acids
US3113146A (en) * 1960-05-09 1963-12-03 Ici Ltd Isocyanates containing silicon
US3240726A (en) * 1960-08-25 1966-03-15 Bayer Ag Polyurethanes prepared from isocyanato phosphorus compounds
US3277212A (en) * 1961-05-25 1966-10-04 Bayer Ag Phosphorous containing isocyanates
US3277211A (en) * 1962-08-10 1966-10-04 Hooker Chemical Corp Pentahalocyclopentadienylsubstituted phosphates
US3341463A (en) * 1964-11-16 1967-09-12 Mobay Chemical Corp Organic polyisocyanates
US20100086860A1 (en) * 2008-10-01 2010-04-08 Bayer Materialscience Ag Photopolymer compositions for optical elements and visual displays
TWI461485B (en) * 2008-10-01 2014-11-21 Bayer Materialscience Ag Photopolymer compositions for optical elements and visual displays

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