US2812283A - Therapeutic solvent vehicle - Google Patents

Therapeutic solvent vehicle Download PDF

Info

Publication number
US2812283A
US2812283A US198236A US19823650A US2812283A US 2812283 A US2812283 A US 2812283A US 198236 A US198236 A US 198236A US 19823650 A US19823650 A US 19823650A US 2812283 A US2812283 A US 2812283A
Authority
US
United States
Prior art keywords
ester
decyl
found
cis
percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US198236A
Inventor
Charles F Geschickter
Martin I Rubin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GESCHICKTER FUND FOR MEDICAL RESEARCH Inc
GESCHICKTER FUND MED RES
Original Assignee
GESCHICKTER FUND MED RES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GESCHICKTER FUND MED RES filed Critical GESCHICKTER FUND MED RES
Priority to US198236A priority Critical patent/US2812283A/en
Application granted granted Critical
Publication of US2812283A publication Critical patent/US2812283A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Definitions

  • the present invention relates to combinations of esters of cis-A -tetrahydrophthalic acid and vegetable oils which have been foundto be excellent 'sol vents and vehicles for therapeutic materials bothfor injection purposes and oral administration.
  • R may be equal to R1 in the case of symmetrical esters and in that event R and R1 are straight chain or branch chain alkyl or aralkyl groupings of from six to ten carbons each.
  • R and R1 may be hexyl, decyl or octyl.
  • R and R1 may be alkyl or aralkyl radicals andthe number of carbon atoms in both R and R1jmay vary between ten and twenty.
  • R may be ethyl and R1 decyl; R may be butyl and R1 decyl; R may be hexyl and R1 decyl and R may be hexyl and R1 octyl.
  • R should contain at least two carbon atoms since the methyl esters have not proven particularly effective for the purposes hereinafter set forth.
  • the above compounds, in combination with a suitable vegetable oil, have been found to be especially useful solvents for therapeutic agents and have also been effective therapeutics in themselves.
  • the vegetable oils involved are preferably non-drying oils of the type ordinarily used for injection purposes, such as peanut oil, sesame oil or corn oil and in general may be characterized as glycerides or esters of long-chain saturated and unsaturated monocarboxylic acids having from twenty to twelve carbon atoms, inclusive.
  • the vegetable oils involved are, of course, preferably liquid at ordinary temperatures.
  • a great many therapeutic compounds have been found to be highly soluble in the combination of esters and vegetable oil hereinbefore described, and the combination when used for injection purposes has been found to be especially nonirritating and nontoxic.
  • the vegetable oil and phthalate ester combination above described has been found to enhance the action of certain therapeutics so much as to exhibit a synergistic effect in combination therewith.
  • compositions have been found to be the combination of the dioctyl ester of cis-M-tetrahydrophthalic acid and a vegetable oil, especially sesame oil, and compounds of the character described in Geschreiber and Rubin applications Serial Nos. 118,997 and 118,998, both filed on September 30, 1949, now Patent No. 2,594,418 and Patent No. 2,594,419, have been found to be more effective for the treatment of respiratory dis- 2,812,283 Patented Nov. 5, 1957 "ice cases than the compounds themselves.
  • pentaquine salicylate i. e.
  • the salicylic acid salt of 8-(5- isopropylaminoamylamino) 6 methoxy quinoline dissolved in the dioctyl ester of cis-M-tetrahydrophthalic acid and sesame oil has been found to be especially effeclive for the treatment of asthma and other respiratory ailments. Further, the combination of the dioctyl ester of cis-A -tetrahydrophthalic acid and sesame oil has been found to maintain beneficial results in ailments of this same type.
  • novel vehicles of the present invention have also been found to be suitable for dissolving antibiotics, such as penicillin and chloromycetin, as well as other therapeutic compounds normally administered by injection.
  • the phthalate ester may form from twenty to eighty percent of the vehicle, with the balance eighty to twenty percent by weight being a vegetable oil of the character described. If desired, a portion of the phthalate ester may be replaced by an additional solvent such as benzyl alcohol. In general, however, no more than twenty percent of the vehicle can be benzyl alcohol. However, with the addition of the benzyl alcohol higher concentrations of therapeutic compounds may be achieved.
  • a vehicle a hundred milligrams per cc. solution of calcium decyl tetrahydrophthalate may be prepared in the combination of fifty percent vegetable oil, such as sesame oil, and fifty percent of dioctyl tetrahydrophthalate.
  • a suitable and effective solution of a hundred milligrams per cc. may also be prepared using sixty percent of sesame oil and forty percent of the ester.
  • a combination best used is twenty percent of benzyl alcohol, forty percent of the dioctyl ester and forty percent of oil.
  • the calcium decyl tetrahydrophthalate is first dissolved in the benzyl alcohol, the solution is then added to the ester and finally the oil is added.
  • the calcium decyl tetrahydrophthalate is first dissolved in the ester and then the vegetable oil added.
  • the final composition may be utilized for injection purposes, i. e. intramuscular injection or it may be capsulated into suitable capsules and administered orally.
  • the combination has been found to be especially effective as a uterine relaxing agent in cases of dismenorrhea.
  • the combination of vegetable oil, such as sesame oil and dioctyl tetrahydrophthalate has been found suitable for preparing relatively high concentration solutions of pentaquine salicylate previously referred to.
  • a mixture of sixty percent vegetable oil, thirty percent of dioctyl A -tetrahydrophthalate and ten percent of benzyl alcohol will readily dissolve up to thirty milligrams per cc. of pentaquine salicylate.
  • forty percent of the phthalate ester and sixty percent of vegetable oil will serve to dissolve up to fifteen milligrams per cc. of pentaquine salicylate.
  • Example I Preparation of unsymmetrical esters of cis-M-tetrahyhydrophthalic acid was prepared by adding an aqueous silver nitrate solution in excess to a solution of ammonium decyl 'cis-At-tetrahydrophthalate which had been made slightly alkaline with ammonium hydroxide. 'The White silver salt which precipitated was removed by filtration and dried by. aieo'tropic distillation with benzene. To' thedry silver salt suspended in the benzene solvent was added an excess of ethyl io'dide. The mixture was heated under reflux overnight, filtered from the precipitated silver halide and then fractionally distilled.
  • the ethyl decyl ester of tetrahydrophthalic. acid had a boiling point of 148-152" at 0.3 mm.
  • Analysis for carbon showed 71.1% against 710% for theory and 10.1% of hydrogen as compared to 10.1% theory.
  • Example II The preparation of the symmetrical esters of 'cis-A tetrahydrophthalic acid: Av mixture of 0.3 moliof tetrahydrophthalic anhydride and the appropriate alcohol (0.8
  • Example III 2000 mg, of gpentaquine salicylate were dissolved in 100 cc. of 'dioctyl cis- At-tetrahydrophthalate. Thereafter the solution thus formed was added to 100 cc. of sesame oil. The resultant solution was then filled into capsules so that each capsule contained 5 mg. of pentaquine salicylate, cc. "of thephth'a'late ester and A cc. of sesame oil. A number of patients having asthma were treated with doses varying from'one to four ofthese capsules daily and symptoms were greatly alleviated. The solution was also suitable for intramuscular injection.
  • a solvent ve hicle for therapeutics comprising from 20 t 80% ofi ifif dioctyl ester of cis-A -tetrahydrophthalic acid and 20 to 80% of a vegetable oil.
  • 'ZQATtherapeut'ic composition comprising the salicylic acid 'salt of '8-(5 isopropylaminoamylamino)-6-rnethoxy quinoline dissolve d in the dioctyl ester'of cis-A tejtrahydropht'halic ac id'a'nd sesame oil.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Description

United States Patent THERAPEUTIC soLvENT VEHICLE Charles F. Geschickter, Rock Creek Hills, andMartiu I. Rubin, Silver Spring, Md., assignors to Geschickter Fund for Medical Research, Inc., New York, N. Y., a corporation of New York N 0 Drawing. Application November 29, 1950,
Serial No. 198,236
2 Claims. Cl. 167-82) The present invention relates to novel vehicles and therapeutics. p
More particularly the present invention relates to combinations of esters of cis-A -tetrahydrophthalic acid and vegetable oils which have been foundto be excellent 'sol vents and vehicles for therapeutic materials bothfor injection purposes and oral administration.
The esters involved may be characterized by the following general formula:
COOK! In the foregoing formula R may be equal to R1 in the case of symmetrical esters and in that event R and R1 are straight chain or branch chain alkyl or aralkyl groupings of from six to ten carbons each. For example, both R and R1 may be hexyl, decyl or octyl.
The unsymmetrical esters of the character described are also within the scope of the present invention and here again R and R1 may be alkyl or aralkyl radicals andthe number of carbon atoms in both R and R1jmay vary between ten and twenty. As typical examples, R may be ethyl and R1 decyl; R may be butyl and R1 decyl; R may be hexyl and R1 decyl and R may be hexyl and R1 octyl. In the case of the unsymmetrical esters, however, R should contain at least two carbon atoms since the methyl esters have not proven particularly effective for the purposes hereinafter set forth.
The above compounds, in combination with a suitable vegetable oil, have been found to be especially useful solvents for therapeutic agents and have also been effective therapeutics in themselves. The vegetable oils involved are preferably non-drying oils of the type ordinarily used for injection purposes, such as peanut oil, sesame oil or corn oil and in general may be characterized as glycerides or esters of long-chain saturated and unsaturated monocarboxylic acids having from twenty to twelve carbon atoms, inclusive. The vegetable oils involved are, of course, preferably liquid at ordinary temperatures. A great many therapeutic compounds have been found to be highly soluble in the combination of esters and vegetable oil hereinbefore described, and the combination when used for injection purposes has been found to be especially nonirritating and nontoxic. In addition, the vegetable oil and phthalate ester combination above described has been found to enhance the action of certain therapeutics so much as to exhibit a synergistic effect in combination therewith.
An especially desirable composition has been found to be the combination of the dioctyl ester of cis-M-tetrahydrophthalic acid and a vegetable oil, especially sesame oil, and compounds of the character described in Geschickter and Rubin applications Serial Nos. 118,997 and 118,998, both filed on September 30, 1949, now Patent No. 2,594,418 and Patent No. 2,594,419, have been found to be more effective for the treatment of respiratory dis- 2,812,283 Patented Nov. 5, 1957 "ice cases than the compounds themselves. For example, pentaquine salicylate, i. e. the salicylic acid salt of 8-(5- isopropylaminoamylamino) 6 methoxy quinoline dissolved in the dioctyl ester of cis-M-tetrahydrophthalic acid and sesame oil, has been found to be especially effeclive for the treatment of asthma and other respiratory ailments. Further, the combination of the dioctyl ester of cis-A -tetrahydrophthalic acid and sesame oil has been found to maintain beneficial results in ailments of this same type. The combination of an ester as above described of cis-M-tetrahydrophthalic acid and a vegetable oil has also been found to be especially effective as a vehicle for dissolving antispasmodic compounds, such as calcium and magnesium salts of alkyl ester of cis-A tetrahydrophthalic acid, for example, calcium decyl tetrahydrophthalate, these compounds being disclosed in particular in the application of Reid and Geschickter, Serial No. 753,808, filed June 10, 1947, and now abandoned.
The novel vehicles of the present invention have also been found to be suitable for dissolving antibiotics, such as penicillin and chloromycetin, as well as other therapeutic compounds normally administered by injection. In preparing the vehicles of the present invention the phthalate ester may form from twenty to eighty percent of the vehicle, with the balance eighty to twenty percent by weight being a vegetable oil of the character described. If desired, a portion of the phthalate ester may be replaced by an additional solvent such as benzyl alcohol. In general, however, no more than twenty percent of the vehicle can be benzyl alcohol. However, with the addition of the benzyl alcohol higher concentrations of therapeutic compounds may be achieved.
As an illustration of the use of the present combination as ,a vehicle a hundred milligrams per cc. solution of calcium decyl tetrahydrophthalate may be prepared in the combination of fifty percent vegetable oil, such as sesame oil, and fifty percent of dioctyl tetrahydrophthalate. A suitable and effective solution of a hundred milligrams per cc. may also be prepared using sixty percent of sesame oil and forty percent of the ester. However, if it is desired to prepare a solution of calcium decyl tetrahydrophthalate having a concentration of two hundred milligrams per cc., a combination best used is twenty percent of benzyl alcohol, forty percent of the dioctyl ester and forty percent of oil. In preparing the solutions of the character just described, the calcium decyl tetrahydrophthalate is first dissolved in the benzyl alcohol, the solution is then added to the ester and finally the oil is added. On the other hand, if no benzyl alcohol is used then the calcium decyl tetrahydrophthalate is first dissolved in the ester and then the vegetable oil added.
The final composition may be utilized for injection purposes, i. e. intramuscular injection or it may be capsulated into suitable capsules and administered orally. The combination has been found to be especially effective as a uterine relaxing agent in cases of dismenorrhea. Simi larly, the combination of vegetable oil, such as sesame oil and dioctyl tetrahydrophthalate has been found suitable for preparing relatively high concentration solutions of pentaquine salicylate previously referred to. For example, a mixture of sixty percent vegetable oil, thirty percent of dioctyl A -tetrahydrophthalate and ten percent of benzyl alcohol will readily dissolve up to thirty milligrams per cc. of pentaquine salicylate. In the absence of the benzyl alcohol forty percent of the phthalate ester and sixty percent of vegetable oil will serve to dissolve up to fifteen milligrams per cc. of pentaquine salicylate.
The following specific examples serve to illustrate but are not intended to limit the present invention:
Example I Preparation of unsymmetrical esters of cis-M-tetrahyhydrophthalic acid was prepared by adding an aqueous silver nitrate solution in excess to a solution of ammonium decyl 'cis-At-tetrahydrophthalate which had been made slightly alkaline with ammonium hydroxide. 'The White silver salt which precipitated was removed by filtration and dried by. aieo'tropic distillation with benzene. To' thedry silver salt suspended in the benzene solvent was added an excess of ethyl io'dide. The mixture was heated under reflux overnight, filtered from the precipitated silver halide and then fractionally distilled. The ethyl decyl ester of tetrahydrophthalic. acid had a boiling point of 148-152" at 0.3 mm. Analysis for carbon showed 71.1% against 710% for theory and 10.1% of hydrogen as compared to 10.1% theory.
' Similarly prepared were the benzyl decyl esterboiling point 189193 at 0.7 mm.; the butyl decyl esterboil' ing point 155-160 at 0.3 mm.'; the he'xyl decyl ester. boiling point 160,l63 at 0.3 mm.; and the hexyl octyl ester-boiling point 156160 at 0.3 mm.
Example II The preparation of the symmetrical esters of 'cis-A tetrahydrophthalic acid: Av mixture of 0.3 moliof tetrahydrophthalic anhydride and the appropriate alcohol (0.8
free of the alkali with water, dried over magnesiumsulphate (anhydrous), filtered and purified byfractionation. By this procedure the following symmetrical esters were prepared:
p Diethyl ester from heptyl alcohol'and tetrahydrophthalic alnhydride boilin'g point 163168 0.7 mm. Analysis for carbon'7l.8%. Found against 72.1% theory. Analysis for hydrogen found 104% against 10.5% theory.
Dioctyl ester from octyl alcohol and tetrahydrophthalic anhydride boilingpoint 195-19 7 0.7 mm. Analysis for carbon fauna 72.8%, theory 73.1%. Analysis for hydrogen found 10.8%, theory 10.7%.
The di-decyl ester from decyl alcohol and tetrahydrophthalic anhydrideboiling point 165170, 0.3 mm.
Example III 2000 mg, of gpentaquine salicylate were dissolved in 100 cc. of 'dioctyl cis- At-tetrahydrophthalate. Thereafter the solution thus formed was added to 100 cc. of sesame oil. The resultant solution was then filled into capsules so that each capsule contained 5 mg. of pentaquine salicylate, cc. "of thephth'a'late ester and A cc. of sesame oil. A number of patients having asthma were treated with doses varying from'one to four ofthese capsules daily and symptoms were greatly alleviated. The solution was also suitable for intramuscular injection.
We claim:
1. A solvent ve hicle for therapeutics comprising from 20 t 80% ofi ifif dioctyl ester of cis-A -tetrahydrophthalic acid and 20 to 80% of a vegetable oil.
'ZQATtherapeut'ic composition comprising the salicylic acid 'salt of '8-(5 isopropylaminoamylamino)-6-rnethoxy quinoline dissolve d in the dioctyl ester'of cis-A tejtrahydropht'halic ac id'a'nd sesame oil.
References Cited in the file of this patent UNITED STATES PATENTS 2,275,034 Moyle Mar. 3, 1942 2,275,335 Soday Mar. 3, 1942 2,384,955 7 Moyle Sept. 18, 1945 2,445,627 :Morris et' a1. July 20, 1948 2.544172. 0 Miller Mar. 6,1951
OTHER REFERENCES Beilstein, vol.- 9,- Berlin, 1926, pp. 772-774.
Arch. Ind. Hyg. Occup. Med., vol. 4, pp. 119-122 1951) (as 'c'ited in'Chem. 'Abstr., vol. 45, p. 9710g).

Claims (1)

1. A SOLVENT VEHICLE FOR THERAPEUTICS COMPRISINF FROM 20 TO 80% OF THE DIOCTYL ESTER OF CIS-$4-TETRAHYDROPHTHALIC ACID AND FROM 20 TO 80% OF A VEGETABLE OIL.
US198236A 1950-11-29 1950-11-29 Therapeutic solvent vehicle Expired - Lifetime US2812283A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US198236A US2812283A (en) 1950-11-29 1950-11-29 Therapeutic solvent vehicle

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US198236A US2812283A (en) 1950-11-29 1950-11-29 Therapeutic solvent vehicle

Publications (1)

Publication Number Publication Date
US2812283A true US2812283A (en) 1957-11-05

Family

ID=22732548

Family Applications (1)

Application Number Title Priority Date Filing Date
US198236A Expired - Lifetime US2812283A (en) 1950-11-29 1950-11-29 Therapeutic solvent vehicle

Country Status (1)

Country Link
US (1) US2812283A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105793A (en) * 1956-11-28 1963-10-01 Lobel Mervyn Joseph Injectable medicinal composition
EP0003382A1 (en) * 1978-01-20 1979-08-08 Acf Chemiefarma Nv Solvent vehicle for therapeutics and pharmaceutical composition containing it
EP1205534A1 (en) * 1999-07-05 2002-05-15 Nippon Mitsubishi Oil Corporation Refrigerating oil composition
US20090312470A1 (en) * 2008-06-11 2009-12-17 Ferro Corporation Asymmetric Cyclic Diester Compounds
US20100113664A1 (en) * 2008-06-11 2010-05-06 Ferro Corporation Asymmetric Cyclic Diester Compounds

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2275385A (en) * 1940-01-11 1942-03-03 United Gas Improvement Co Alkyl esters of 3-methyl-delta4-tetrahydrophthalic acid
US2275034A (en) * 1941-05-02 1942-03-03 Dow Chemical Co Esters of 4-cyclohexene-1, 2-dicarboxylic acid
US2384955A (en) * 1941-10-01 1945-09-18 Dow Chemical Co Esters of 4-cyclohexene-1, 2-dicarboxylic acid
US2445627A (en) * 1944-09-19 1948-07-20 Shell Dev Monomeric and polymeric unsaturated esters and their production
US2544272A (en) * 1948-01-08 1951-03-06 Lilly Co Eli Penicillin salt suspensions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2275385A (en) * 1940-01-11 1942-03-03 United Gas Improvement Co Alkyl esters of 3-methyl-delta4-tetrahydrophthalic acid
US2275034A (en) * 1941-05-02 1942-03-03 Dow Chemical Co Esters of 4-cyclohexene-1, 2-dicarboxylic acid
US2384955A (en) * 1941-10-01 1945-09-18 Dow Chemical Co Esters of 4-cyclohexene-1, 2-dicarboxylic acid
US2445627A (en) * 1944-09-19 1948-07-20 Shell Dev Monomeric and polymeric unsaturated esters and their production
US2544272A (en) * 1948-01-08 1951-03-06 Lilly Co Eli Penicillin salt suspensions

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3105793A (en) * 1956-11-28 1963-10-01 Lobel Mervyn Joseph Injectable medicinal composition
EP0003382A1 (en) * 1978-01-20 1979-08-08 Acf Chemiefarma Nv Solvent vehicle for therapeutics and pharmaceutical composition containing it
US4296131A (en) * 1978-01-20 1981-10-20 Acf Chemiefarma N.V. Pharmaceutical compositions and their use in the prophylaxis and/or treatment of certain diseases
EP1205534A1 (en) * 1999-07-05 2002-05-15 Nippon Mitsubishi Oil Corporation Refrigerating oil composition
EP1205534A4 (en) * 1999-07-05 2009-04-01 Nippon Mitsubishi Oil Corp Refrigerating oil composition
US20090312470A1 (en) * 2008-06-11 2009-12-17 Ferro Corporation Asymmetric Cyclic Diester Compounds
US20100113664A1 (en) * 2008-06-11 2010-05-06 Ferro Corporation Asymmetric Cyclic Diester Compounds
EP2307476A1 (en) * 2008-06-11 2011-04-13 Ferro Corporation Asymmetric cyclic diester compounds
EP2307476A4 (en) * 2008-06-11 2011-08-10 Ferro Corp Asymmetric cyclic diester compounds

Similar Documents

Publication Publication Date Title
EP0084865B1 (en) Propylene glycol diester solutions of pge-type compounds
IE52536B1 (en) Carbonate diester solutions of pge-type compounds
US2812283A (en) Therapeutic solvent vehicle
US2474729A (en) Insulin preparations
US3959492A (en) Method for reducing serum blood cholesterol
NZ204924A (en) Pge-type prostaglandins in stabilising solvent encapsulated in type a gelatin
SE467340B (en) USE OF INOSITOL MONOPHOSPHATE FOR THE PREPARATION OF AN EFFECTIVE EFFECT AS A NEUROPEPTID Y (NPY) ANTAGONIST
Drake et al. Some N1-(6-methoxy-8-quinolylaminoalkyl)-guanidines
US3345264A (en) Methods of suppressing anxiety employing sodium and iron salts of pyrrolidone carboxylic acid
US2259492A (en) Therapeutic preparation of bismuth and method of preparing same
US2910403A (en) Anti hypertensive compositions comprising 2-methyl-5, 8-dimethoxychromone and acetamides
US2941924A (en) Monoethanolamine salt of alpha-(acetylamino)-isocaproic acid
US3542826A (en) Cobalt dodecenedioate and use thereof
US2464284A (en) Vasoconstrictor composition
US2128741A (en) Amine hydriodides
US2939817A (en) Method of treating diseases associated with plasmin activity
US3181994A (en) Analgesic biphenyl acetic acid derivatives
US2472453A (en) Streptomycin composition of reduced toxicity
US1690705A (en) Benzoic acid salt of amino benzoic esters
Dallos et al. The comparative value of amantadine and levodopa
US2196495A (en) Isopropanolamine salts of theophylline and process of making them
IL26708A (en) 1,4-benzodioxane derivatives and their preparation
US3127316A (en) Cardiac auricular therapy with quesfl-
SE7513126L (en) NEW Nitrogen-containing, POLYCYCLIC ASSOCIATIONS JUST SEEN FOR THEIR PREPARATION
US3887706A (en) N6-(3-Chlorobuten-2-yl)-adenosines as anti-inflammatory agents