US2474665A - Pneumatic blood treating apparatus - Google Patents

Pneumatic blood treating apparatus Download PDF

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US2474665A
US2474665A US65022446A US2474665A US 2474665 A US2474665 A US 2474665A US 65022446 A US65022446 A US 65022446A US 2474665 A US2474665 A US 2474665A
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blood
container
subject
oxygen
chamber
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John R Guarino
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Frank J Guarino
Vincent T Guarino
Louis J Guarino
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/32Oxygenators without membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/1001General aspects of blood pumps irrespective of pump type
    • A61M1/1006Blood pumps incorporated within another functional device, e.g. an oxygenator, a dialyser or a blood chamber
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/1037Pumps having flexible elements, e.g. with membranes, diaphragms, or bladder pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/1037Pumps having flexible elements, e.g. with membranes, diaphragms, or bladder pumps
    • A61M1/1046Drive systems therefor, e.g. mechanically, electromechanically or skeletal muscle drive means
    • A61M1/106Drive systems therefor, e.g. mechanically, electromechanically or skeletal muscle drive means using hydraulic or pneumatic means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/1087Active valves for blood pumps or artificial hearts, i.e. using an external force for actuating the valve
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/1096Passive valves for blood pumps or artificial hearts, i.e. valves actuated by the fluid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00Surgery
    • Y10S128/03Heart-lung

Description

June 28, 1949. J. R. GUARINO PNEUMATIC BLOOD TREATING APPARATUS 2 Sheets-Sheet 1 Filed Feb. 26, 1946 FIG.3.

FIG-.2.

7E INVENTOB June 28, 1949. J. R. GUARINO PNEUMATIC BLOOD TREATING APPARATUS 2 Sheets-Sheet 2 Filed Feb. 26, 1946 FIG.7.

FIG'.6.

Patented June 28 1949 PNEUMATIC 131.001) TREATING APPARATUS John R. Guarino, Brooklyn, N. Y., assignor of one-fourth to Frank J. Guarino, one-fourth to Vincent T. Guarino, and one-fourth to Louis J.

Guarino, all of Brooklyn, N. Y. e

Application February 2c, 1946, Serial No. 650,224

This invention relates to methods and improvements in blood treating devices.

One object of this inventionis to provide an apparatus which may function as a part of the human circulatory system, and permit and control a flow of blood through said apparatus. Another object of this invention is to expose the blood of a given subject to a pneumatic medium which will enable the blood to be treated during its circula tion through the apparatus without clotting of the blood or formation of emboli in the circulatory system.

I accomplish these objects by methods and apparatus illustrated in the accompanying drawings, in which i i Fig. 1 is an assembly view of the apparatus which may be made of glass, quartz, metal, refractory or plastic material. The interior of this apparatus may be wax lined or wax coated.

Fig. 2 is a plan view of the chamber proper of the apparatus with all attachments removed.

Fig. 3 is a sectional view of the chamber taken along the line 3-3 of Fig. 2.

Fig. i is an assembly view of the entire apparatus showing an alternate method in which I use a double passage needle so that only one venipuncture is necessary. Such double passage needle may be made of glass, metal or plastics. I will refer to this needle throughout this specification as the double passage needle.

Fig. 5 is a plan view of the double passage needle.

Fig. 6 is a side view of the double passage needle.

Fig. '7 is a sectional view of the double passage needle, taken along the line l-"l of Fig. 5. Similar numerals refer to similar parts throughout the several views.

Following is a detailed description of my process in which this apparatus simulates the function of the human lung. This description will also serve to explain the methods by which I accomplish the aforementioned objects.

In Fig. 1, a veni-puncture needle I is inserted into a vein distal to a tourniquet applied to the arm or other anatomical regioninorder to establish the desired blood pressure gradients, unless it is inserted into an artery where the desired blood pressure gradients already exist. The blood will enter the veni-puncture needle I and flow through the conduit 2,thence through the nozzle 4, and thereupon into the chamber 3. Oxygen from the supply vessel 1 may pass through the nozzle 8 into the container or chamber 3 under a pressure regulated by means of a throttle valve,

7 Claims. (01. 128-4214) such as the valve 25, when the level of the blood rises to an elevation preferably below the entrance of the nozzle 4 and above the exit to the nozzle |0, the oxygen disposed in the area above the level of the blood will form a controllable pneumatic cushion; thereby providing an elastic medium which will control the flow of blood through the chamber 3. Some of this oxygen is absorbed by the reduced hemoglobin of the blood in the chamber 3 due to the partial pressure difference between the oxygen of the entering blood and the oxygen above the surface of the blood within the chamber 3. As a result thereof, oxygen may be absorbed by the blood to the limit of physiologicalrequirements. Nitrous oxide, nitrous oxide-oxygen or othergases, or gases of volatile liquids such as ether, similarly may be introduced into the chamber 3 to be absorbed by the blood.

Carbon dioxide contained in the blood will be liberated in the chamber 3 to the extent of the partial pressure difierences between the carbon dioxide of the blood and the carbon dioxide in the chamber 3. The liberted carbon dioxide passing out through the nozzles ,5 may be absorbed by a carbon dioxide absorbing agent such as lime water contained inthe vessels 8. In this way, the carbon dioxide in the blood may be liberated to the limit of physiological requirements. Other gases .or volatile liquids contained in the blood similarly maybe liberated from the blood and be absorbed by suitable absorbing agents.

An anti-coagulant such as sodium citrate contained in the vessel 9 maybe injected into the blood, it necessary, at nozzle 4. The treated blood passes out from the chamber 3 through the nozzle IE and. conduit H, thence through the venipuncture needle l2, which may be inserted into the desired :blood channel. A pressure gauge, suchasamanometer 13, maybe attaohedto the nozzle M for recording the pressure within the chamber 3. Themanometer l3 may be calibrated to record the quantity flow of the blood in the chamber 3. i

In Fig. lthere is shown an apparatus according to an alternate method bywhic'h the blood may be withdrawn and returned from and to the blood stream by the use of one veni-puncture needle 55, having a double passage way 16 and H, as shown in Fig. 7, by means of which the blood from a vein or artery enters the needle through the open-- ing It and then passes through the passage way ll out through the opening l9 into the conduit 2, through nozzle 4, and into the chamber 3. The blood after treatment passes out from the chant her 3 through the nozzle l0, thence through the conduit H, through the opening 20, thence through the passage Way l6 and out of the opening 2! into the blood stream. When the double passage needle I is inserted into the blood vessel 22, a tourniquet 23 may be applied to the arm 24, or other anatomical region of the subject, along the axis of the double passage needle l5, between the inlet opening l8, and the outlet opening 2|, in order to induce the blood pressure gradients desired.

It may be noted here, that althoughthis apparatus would function if the-chamber 3 were exposed to the open atmosphere'by raising the chamber to such a height that the blood in the chamber would attain its own hydraulic level, I prefer to supply a certain selected gas or gases into the chamber under a regulated pressure in order to make the apparatus more clinically applicable. Also, I wish to point out that with a regulated gas pressure in the chamber, this apparatus could function if one or more nozzles of the chamber 3, were open to the atmosphere. However, I prefer to maintain a closed system in order to measure gaseous exchanges to and from the blood.

It is known to me that heretofore, attempts have been made to inject oxygen gas intravenously for therapeusis. The reports on the failure of these attempts on intravenous oxygen therapy are given by F. S. Grodins, A. C. Ivy,

and H. F. Adler, of the Department of Physiology and Pharmacology of Northwestern University Medical school, and published in the Journal of Laboratory and Cinical Medicine, volume 28, 1942-1943, page 1013, entitled, Intravenous Administration of Oxygen, in which they state: Intravenous oxygen was not only unable to correct an existing anoxia produced by nembutal anesthesia, but actually increased the anoxemia. Thatnembutal anoxemia can be corrected. by oxygen inhalation hasbeen reported by Schnedorf and McClure and associates and confirmed by us. They also state: It would appear that if intravenous oxygen therapy will ever prove to be enicient, some way will have to be found so that significant amounts can be administered without causing bubble formation. It is to be noted that in the aforementioned attempts: at intravenous oxygen therapy, the oxygen was admitted by needle directly into the blood stream, and without provision for carbon dioxide elimination.

In my apparatus, I expose the blood to the oxygen, and also provide means for carbon dioxide elimination.

The higher the carbon dioxide content of the blood, the greater will be the dissociation of oxygen from oxyhemoglobin. Carbon dioxide, therefore, must be taken out of the blood in measured amounts to accomplish full saturation of hemoglobin, and to prevent-premature dissociation of oxygen from oxyhemoglobin.

The influence exerted by carbon dioxide on the afiinity of hemoglobin for oxygen is referred to as the Bohr effect. Reference: Physiological Basis of Medical Practice, Best and Taylor, 3rd edition, pages 540-541.

Since in my apparatus, carbon dioxide is eliminated as is physiologically necessary, oxygen can be absorbed by the blood to the limit of physiological requirements, and anoxemia can be corrected without the formation of gas emboli in the blood.

In summation, I wish to state that in my ape thus eliminating all pumping mechanisms, and because of my control of blood flow, a desired rate of flow is maintained. As a result thereof, the prevention of blood clotting is assured. Since I allow the gaseous exchanges to occur with the blood within physiological requirements, gas emboli will not form.

It may be mentioned that additional therapeusis may be administered to the blood by providing an additional nozzle or nozzles, such as nozzle [4, to chamber 3, Figure 3. For example, solutions such as glucose and saline, and drugs such as penicillin and sulfonamides, or other medication may be administered through the chamber.

My apparatus points to uses and applications in the fields of clinical medicine and surgery that are not mentioned in my specifications, nor provided for in my drawings, but fall within the scope of my invention.

l. The combination of an'enclosed container, a discharge conduit in communication with the lower end of said container, a supply conduit in communication with said container above the lower end thereof and below the upper end thereof, the free ends of said conduits connected to the blood stream of a subject'to by-pass'blood from the subject through the supply conduit, container and discharge conduit, back to the subject, relyin in part upon the propagating force of the heart of the subject to effect the flow of the blood through the container, and a gas supply in communication with the'upper end of said container above the supply conduit to form a pneumatic cushion above the surface of the blood in the container, the pressure of the gas supply exceeding the pressure of the oxygen entering through the supply conduit to supplement the heart in effecting the flow of the blood from the subject through the container and back to the subject.

2. The combination of an enclosed container, a discharge conduit in communication with the lower end of said container, a supply conduit in communication with said container above the lower end thereof and below the upper end thereof, the free ends of said conduits connected to the blood stream of a subject to by-pass blood from the subject through the supply conduit, container and discharge conduit, back to the subject, relying in part upon the propagating force of the heart of the subject toeffect the flow of the blood through the container, and an oxygen supply under pressure connected to the upper end of said container to form a pneumatic cushion above the surface of the blood in the container, the pressure of the oxygen above the surface of the blood in the container exceedin the pressure of the oxygen in the blood entering through the supply conduit to supplement the heart in effecting the flow of the blood from the subject through the container and back to the subject.

3. The combination ofan" enclosedcontainer, a discharge conduit in communication with the lower end of said container, a supply conduit in communication with said container above the lower end thereof, the free ends of said'conduits connected to the blood stream of a subject to by-pass blood from the subject through'the supply conduit, container and discharge conduit, back to the subject, relying in part upon the propagating force of the heart of the subject to effect the flow of the blood through the container, an oxygen supply in communication with the upper end of said container to form a pneumatic cushion above the surface of the blood in the container, and a gas absorbing agent in communication with the upper end of said container to absorb obnoxious gases liberated by the blood while passing through said container and facilitate the absorption of the oxygen from the supply formed by the pneumatic cushion.

4. The combination of an enclosed container, a discharge conduit in communication with the lower end of said container,a supply conduit in communication with said container above the lower end thereof, a double passage veni-puncture needle connected to the free ends of said conduits to enable the needle to be inserted into a blood vessel of the subject with the free ends of the needle exposed to the blood stream in one and the same blood vessel, the free ends of the needle being spaced from one another to enable the tourniquet to interrupt the flow in the bleed vessel between the two free ends of the needle and thereby enable the blood to be withdrawn from and return to one and the same blood vessel through one puncture in such vessel.

5. The combination of an enclosed container, a discharge conduit in communication with the lower end of said container, a supply conduit in communication with said container above the lower end thereof and below the upper end thereof, the free ends of said conduits connected to the blood stream of a subject to by-pass blood from the subject through the supply conduit, container and discharge conduit, back to the subject, relying in part upon the propogating force of the heart of the subject to effect the flow of the blood through the container, and a supply of an extraneous gas under pressure in excess of the pressure of the gas in the blood entering through the supply conduit, the upper end of the container above the surface of the blood being closed and containing, and being in communication with said supply of an extraneous gas to supplement the heart in effecting the flow of the blood from the subject through the container and back to the subject.

6. The combination of an enclosed container, a discharge conduit in communication with the lower end of said container, a supply conduit in communication with said container above the lower end thereof and below the upper end thereof, the free ends of said conduits connected to the blood stream of a subject to by-pass blood from the subject through the supply conduit, container and discharge conduit, back to the subject, relying in part upon the propogating force of the heart of the subject to effect the flow of the blood through the container, a gas absorbing agent, an extraneous gas supply under a pressure in excess of the pressure of the gas in the blood entering through the supply conduit, and a closed gas exchange chamber formed in the upper end of the container above the supply conduit and in communication with said gas absorbing agent to absorb obnoxious gases liberated by the bleed while passing through said container and also in communication with said extraneous gas supply to form a pneumatic cushion above the surface of the blood in the container to supplement the heart in effecting the flow of the blood from the subject through the container and back to the subject.

7. The combination of an enclosed container, a discharge conduit in communication with the lower end of said container, a supply conduit in communication with said container above the lower end thereof, the free ends of said conduits connected to the blood stream of a subject to bypass blood from the subject through the supply conduit, container and discharge conduit, back to the subject, relying in part upon the propagating force of the heart of the subject to effect the flow of the blood through the container, a fluid supply in communication with the upper end of said container to form a pneumatic cushion above the surface of the blood in the container, and a gas absorbing agent in communication with the upper end of said container to absorb obnoxious gases liberated by the blood while passing through said container.

JOHN R. GUARINO.

REFERENCES CITED The following references are of record in the file of this patent:

UNITED STATES PATENTS Number Name Date 1,683,877 Edblom Sept. 11, 1928 2,002,008 Harris May 21, 1935 2,137,132 Cooley Nov. 15, 1938 2,308,516 Knott Jan. 19, 1943 2,406,207 Desmet Aug. 20, 1946 2,409,343 Curtis Oct. 15, 1946 FOREIGN PATENTS Number Country Date 492,770 Germany Mar. 5, 1930 546,947 France 1- Sept. 6, 1922 743,148 France Jan. 6, 1933 OTHER REFERENCES Operative Surgery, vol. IIBickham pp. 207-209 (Copy in Div.

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Cited By (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2652831A (en) * 1952-01-31 1953-09-22 Abraham E Chesler Heart-lung apparatus
US2659368A (en) * 1949-05-28 1953-11-17 Jefferson Medical College Of P Extracorporeal circulation device
US2689565A (en) * 1952-12-08 1954-09-21 Gobel Charles Blood pump
US2693802A (en) * 1951-05-15 1954-11-09 John J Osborn Blood oxygenation
US3756234A (en) * 1971-06-04 1973-09-04 Vital Assists Single needle dialysis
US3927980A (en) * 1973-08-22 1975-12-23 Baxter Laboratories Inc Oxygen overpressure protection system for membrane-type blood oxygenators
USRE29346E (en) * 1971-06-04 1977-08-09 Vital Assists, Inc. Single needle dialysis
US4098275A (en) * 1975-11-28 1978-07-04 Dante Vincent Consalvo Dual flow cannula set
US4134402A (en) * 1976-02-11 1979-01-16 Mahurkar Sakharam D Double lumen hemodialysis catheter
US4540402A (en) * 1982-04-20 1985-09-10 Karl Aigner Double perfusion catheter
US4568329A (en) * 1982-03-08 1986-02-04 Mahurkar Sakharam D Double lumen catheter
US4583968A (en) * 1983-10-03 1986-04-22 Mahurkar Sakharam D Smooth bore double lumen catheter
US4623327A (en) * 1985-02-12 1986-11-18 Mahurkar Sakharam D Method and apparatus for using dual-lumen catheters for extracorporeal treatment
US4627419A (en) * 1984-08-29 1986-12-09 The Board Of Regents, The University Of Texas Blood pump apparatus and method
US4692141A (en) * 1982-03-08 1987-09-08 Mahurkar Sakharam D Double lumen catheter
US4770652A (en) * 1985-02-12 1988-09-13 Mahurkar Sakharam D Method and apparatus for using dual-lumen catheters for extracorporeal treatment
US4808155A (en) * 1986-02-27 1989-02-28 Mahurkar Sakharam D Simple double lumen catheter
US5197951A (en) * 1983-12-14 1993-03-30 Mahurkar Sakharam D Simple double lumen catheter
US5221255A (en) * 1990-01-10 1993-06-22 Mahurkar Sakharam D Reinforced multiple lumen catheter
US5374245A (en) * 1990-01-10 1994-12-20 Mahurkar; Sakharam D. Reinforced multiple-lumen catheter and apparatus and method for making the same
US5690642A (en) * 1996-01-18 1997-11-25 Cook Incorporated Rapid exchange stent delivery balloon catheter
US6248087B1 (en) 1997-08-15 2001-06-19 Therox, Inc. Apparatus for generalized extracorporeal support
US6565807B1 (en) 1999-09-30 2003-05-20 Therox, Inc. Method of blood oxygenation
US6582387B2 (en) 2001-03-20 2003-06-24 Therox, Inc. System for enriching a bodily fluid with a gas
US6602468B2 (en) 1999-09-30 2003-08-05 Therox, Inc. Method of blood oxygenation
US6602467B1 (en) 1998-07-24 2003-08-05 Therox, Inc. Apparatus and method for blood oxygenation
US6613280B2 (en) 2001-03-20 2003-09-02 Therox, Inc. Disposable cartridge for producing gas-enriched fluids
US6676900B1 (en) 1994-12-09 2004-01-13 Therox, Inc. Method for the preparation and delivery of gas-enriched fluids
US6890482B2 (en) 1999-09-30 2005-05-10 Therox, Inc. Apparatus for blood oxygenation
US7008535B1 (en) 2000-08-04 2006-03-07 Wayne State University Apparatus for oxygenating wastewater
US20100143190A1 (en) * 2008-12-04 2010-06-10 Therox, Inc. System for enriching a bodily fluid with a gas having occlusion detection capabilities
US20100145248A1 (en) * 2008-12-04 2010-06-10 Therox, Inc. System for enriching a bodily fluid with a gas having automated priming capabilities
US20100143192A1 (en) * 2008-12-04 2010-06-10 Therox, Inc. Method and device for combined detection of bubbles and flow rate in a system for enriching a bodily fluid with a gas
US20100143191A1 (en) * 2008-12-04 2010-06-10 Therox, Inc. System for enriching a bodily fluid with a gas having a dual-function power switch mechanism
US20100145249A1 (en) * 2008-12-04 2010-06-10 Therox, Inc. System for enriching a bodily fluid with a gas having a removable gas-enrichment device with an information recording element
US8777832B1 (en) 2013-03-14 2014-07-15 The University Of Kentucky Research Foundation Axial-centrifugal flow catheter pump for cavopulmonary assistance
US8906300B2 (en) 2011-08-11 2014-12-09 The University Of Kentucky Research Foundation Even perfusion pump-integrated blood oxygenator

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FR546947A (en) * 1922-02-08 1922-11-27 Device for artificial respiration and circulation
US1683877A (en) * 1927-03-03 1928-09-11 Lester A Edblom Means for treating blood-stream infections
DE492770C (en) * 1930-03-05 Arthur Johnson Medical device for the control of pathogens present in the bloodstream by radiographic and electrification
FR743148A (en) * 1933-03-23
US2002008A (en) * 1933-05-25 1935-05-21 Benjamin Howard Benson Apparatus for blood transfusion
US2137132A (en) * 1937-09-17 1938-11-15 Kenneth L Cooley Duplex needle
US2308516A (en) * 1939-05-01 1943-01-19 Emmet K Knott Method and means for irradiating blood
US2406207A (en) * 1944-10-04 1946-08-20 John P Desmet Blood treating device
US2409343A (en) * 1943-04-05 1946-10-15 Macalaster Bicknell Company Fluid inlet-outlet device, particularly for clinical purposes

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE492770C (en) * 1930-03-05 Arthur Johnson Medical device for the control of pathogens present in the bloodstream by radiographic and electrification
FR743148A (en) * 1933-03-23
FR546947A (en) * 1922-02-08 1922-11-27 Device for artificial respiration and circulation
US1683877A (en) * 1927-03-03 1928-09-11 Lester A Edblom Means for treating blood-stream infections
US2002008A (en) * 1933-05-25 1935-05-21 Benjamin Howard Benson Apparatus for blood transfusion
US2137132A (en) * 1937-09-17 1938-11-15 Kenneth L Cooley Duplex needle
US2308516A (en) * 1939-05-01 1943-01-19 Emmet K Knott Method and means for irradiating blood
US2409343A (en) * 1943-04-05 1946-10-15 Macalaster Bicknell Company Fluid inlet-outlet device, particularly for clinical purposes
US2406207A (en) * 1944-10-04 1946-08-20 John P Desmet Blood treating device

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2659368A (en) * 1949-05-28 1953-11-17 Jefferson Medical College Of P Extracorporeal circulation device
US2693802A (en) * 1951-05-15 1954-11-09 John J Osborn Blood oxygenation
US2652831A (en) * 1952-01-31 1953-09-22 Abraham E Chesler Heart-lung apparatus
US2689565A (en) * 1952-12-08 1954-09-21 Gobel Charles Blood pump
US3756234A (en) * 1971-06-04 1973-09-04 Vital Assists Single needle dialysis
USRE29346E (en) * 1971-06-04 1977-08-09 Vital Assists, Inc. Single needle dialysis
US3927980A (en) * 1973-08-22 1975-12-23 Baxter Laboratories Inc Oxygen overpressure protection system for membrane-type blood oxygenators
US4098275A (en) * 1975-11-28 1978-07-04 Dante Vincent Consalvo Dual flow cannula set
US4134402A (en) * 1976-02-11 1979-01-16 Mahurkar Sakharam D Double lumen hemodialysis catheter
US4568329A (en) * 1982-03-08 1986-02-04 Mahurkar Sakharam D Double lumen catheter
US4692141A (en) * 1982-03-08 1987-09-08 Mahurkar Sakharam D Double lumen catheter
US4540402A (en) * 1982-04-20 1985-09-10 Karl Aigner Double perfusion catheter
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