US2435403A - Cyclic alcohols and their preparation - Google Patents

Cyclic alcohols and their preparation Download PDF

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US2435403A
US2435403A US441245A US44124542A US2435403A US 2435403 A US2435403 A US 2435403A US 441245 A US441245 A US 441245A US 44124542 A US44124542 A US 44124542A US 2435403 A US2435403 A US 2435403A
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butadiene
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Rupert C Morris
Theodore W Evans
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Shell Development Co
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/17Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds
    • C07C29/172Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrogenation of carbon-to-carbon double or triple bonds with the obtention of a fully saturated alcohol

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  • This invention relates to the production of a1 cohols containing a carbocyclic radical attached to the carbinol group. More particularly, the invention relates to the preparation of saturated alcohols containing a monoor polycarbocyclic radical attached to the carbinol group.
  • These alcohols which may be represented by the general formula:
  • the process of the invention comprises the condensation of cyclic and/or acyclic polyolefinic by drocarbons with cyclic and/or acyclic olefinic carbonylic compounds to produce aldehydes or ketones containing an unsaturated carbocyclic radical directly attached to the carbonyl group; and/or the hydrogenation of such unsaturated carbocyclic-substituted aldehydes or ketones to produce the corresponding saturated carbocyclicsubstituted alcohols represented by the first formula of paragraph 1; and/or the further hydrogenation of the saturated carbocyclic-substituted aldehydes or ketones of the type derived by hydrogenation of the products step to produce the corresponding saturated carbocyclic-substitutedalcohols (i. e. the same products as produced in accordance with the first hydrogenation step).
  • hexahydro phenyl carbinol may be obtained from butadiene and acrolein and/or from tetrahydro benzaldehyde.
  • the alcohols containing a saturated carbocyclic radical attached to the carbinol group and prepared in accordance with the process of the invention are valuable solvents, intermediate or starting materials for chemical synthesis as well as useful for many other purposes such as insecticides, plasticizers, drugs, perfumes, etc.
  • Hitherto such alcohols, particularly the secondary alcohols as are here obtained-from an afiolefinic ketone and a conjugated diolefln, have been obtained in the laboratory through the Grignard reaction or by the hydrogenation of the corresponding aromatic compounds (as cyclohexylmethylcarbinol from acetophenone) which procedures have produced yields considerably less than the theoretical amount as well as giving various by-products.
  • polyoleflnic hydrocarbons particularly conjugated diolefins
  • oleflnic carbonylic compounds in particular those laflolefinic ketones and aldehydes] in which a double bond carbon atom is attached by a single bond to the carbonyl carbon atom
  • the ketone or aldehyde may be reacted in the vapor phase or, if in the liquid phase, at a temperature above its normalboiling point and under pressure sufficient at least to maintain it in the liquid phase.
  • the condensation takes place as illustrated by the equation M R v /i Edi-R R (I? wherein each R is a cycloalkyl, alkaryl, aryl or aralkyl radical (which may be further substituted).
  • the reacting diolecfin may likewise be a cyclic compound of the type described, in which case a bicyclic aldehyde or ketone is produced, such as the 2-methyl, 2-a-hydroxy ethyl, bicyclo (2,2,1) heptane, supra.
  • the temperature and reaction time for this condensation step should be regulated with respect to each other. For a higher temperature, a shorter reaction period will elfect the same degree of completeness of the reaction as will a lower hydrogen atom or an alkyl,
  • upper temperature limit is, in general, that at which substantial polymerization of the reacting material or product takes place,
  • the dimer may be formed in considerable amount at temperatures not substantially in excess of about 250 C. and at this temperature the reaction of methyl vinyl ketone with butadiene may reach substantial completion in approximately 30 seconds.
  • the same reaction may require an hour and a half or more.
  • the condensation reaction may also be promoted by increased pressure.
  • This condensation step may be carried out in batch, intermittent or continuous manner. If a continuous mode of operation is desired, this may be conveniently accomplished, for example,
  • reaction in the vapor phase and at or near ordinary atmospheric pressure may conveniently be accomplished by confining the unsaturated aldehyde or ketone and the polyolefin in a suitable chamber such as an autoclave and applying a temperature commensurate with the reaction time and pressure as indicated above. If the gaseous reactants are charged to a reaction vessel equipped with a pressure indicator, the progress of the reaction can be gauged by the decrease in pressure since the condensation step is essentially a union of two molecules to form one molecule with a consequent reduction of the vapor pressure in the reactor.
  • Intimate commingling of the reactants in the execution of the condensation step is desirable. This may be effected, if one or more of the reactants are in the liquid phase, by shaking, stirring or other suitable means; or if the process is being carried out in a continuous vapor phase manner, the gases may be passedthrough reaction tubes or chambers packed with an inert substance such as quartz chips, glass wool, porcelain chips, Raschig rings of noncatalytic material and the like which'also act by way of efiecting a more uniform heat transfer in the reaction space, mini- 'mizing spots of extreme temperature, etc.
  • the essential apparatus, namely, the reaction tube or chambers obviously may be of widely varying design, care being taken, however, to fabricate it of material which will not catalyze the polymerization or decomposition 'of the reactants or products.
  • Example I In an autoclave was placed 1.0 mol g.) of methyl vinyl ketone and 1.1 mols of butadiene (59 g.). The material was heated for 1.5 hours at 100 C. and then fractionated. cyclohexenyl methyl ketone, boiling at 100-101 at 50 mm., was obtained in better than yield.
  • the carbonylic compound which contains an unsaturated carbocyclic radical attached to the carbonyl carbon atom, and which is formed by the above condensation can be selectively hydrogenated in high yield, under carefully controlled conditions as herein described, to produce first the corresponding saturated carbocyclic-substituted ketone or aldehyde and then the corresponding saturated carbocyclic-substituted alcohol. If an aldehyde is employed in the condensation, the hydrogenated product will be a primary alcohol; if a ketone is employed, the hydrogenated product will be a secondary alcohol.
  • the hydrogenation procedure to produce the saturated carbocyclic-substituted alcohol is carried out at a relatively high pressure.
  • a hydrogen pressure of from about 40 to about atmospheres is employed, whereas in hydrogenating cyclohexenyl methyl ketone to cyclohexyl methyl ketone a hytadiene-l,3;
  • a solvent may be used for convenience, such as an alcohol, ester, ether and/or a saturated hydrocarbon, although the reaction does not depend on this solvent and may, as in the continuous, consecutive vapor condensation and hydrogenation procedure, be carried on entirely in the vapor phase, the hydrogenation being effected in a further section of the reaction tube or chamber wherein the condensation is taking place.
  • the temperature employed for this higher pressure range is from about 165 C. to about 100C the necessary temperature decreasing accordingly to correspond with increased pressure.
  • the optimum reaction conditions may vary for individual compounds.
  • a hydrogenation catalyst is conveniently employed to accelerate the reaction. Any of the hydrogenation catalysts known to the art may be utilized with varying degrees of effectiveness. Of those which are especially adapted for such work, Raneys nickel and Adkins copper-chromium oxide are very eflicacious from the viewpoint of both cost and efflciency.
  • Other suitable hydrogenation catalysts are those consisting of or comprising one or more metals, or catalytically active compounds of metals such as Fe, Co, Cu, Pd, Zr, Ti, Th, V, Ta, Ag, Mo, Al and the like. This hydrogenation step of the process is further illustrated by the following:
  • Example II 414 g. of cyclohexenyl methyl ketone prepared as shown in Example I, was placed in a high pressure hydrogenation apparatus together with approximately 5 g. of Raney nickel catalyst per mol of cyclohexenyl methyl ketone. The vessel was heated to 165 C. and the hydrogen pressure raised to 40 atmospheres. After completion of the hydrogenation, there was obtained 380 g, of cyclohexyl methyl carbinol boiling at 108-9 at 50 mm., and at 812 at mm. 1
  • the polyolefins employed as the starting material according to the present invention may be such compounds as butadiene-1,3 (bivinyl), isoprene (2-methylbutadiene-1,3) chloroprene (2-chlorbutadiene-l,3), pentadiene-1,3 (piperylene), 2-ethylbutadiene-1,3; Z-haloethylbutadiene-1,3; 2,3-Mez-butadiene-L3 (methylisoprene); 1,4-Mez-butadiene-L3; 2,3-dihalobu- 2,3-halo ethyl halobutadiene,1,3; iuran, cyclopentadiene, cyclohexadiene, anthracene, thiophene, pyrrole, iulvenes, a and B terpinene, a and ,8
  • the unsaturated carbonylic compounds utilized as the starting material to condense with the above polyolefins, according to the process of the present invention, of which the up olefinic carbonylic compounds are a preferred class, are such compounds as acrolein, oz methacrolein, or ethyl acrolein, a propyl acrolein, crotonaldehyde, tiglic pound, preferably aldehyde, p-methyl-crotonaldehyde, up dimethylcrotonic aldehyde, cltral, nonadiene-(2,6) -al-(1) methyl vinyl ketone (methylene acetone), methyl isopropenyl ketone, artemesia ketone, vinyl phenyl ketone, propenyl phenyl ketone, methyl cinnamyl ketone, distyryl-ketone, styryl phenyl ketone, e
  • a process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone at a temperature or about 100 C. and at a pressure sufllcient to maintain the methyl vinyl ketone in the liquid Phase, re-
  • a process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone at a temperature or about C. and at a pressure suflicient to maintain the methyl vinyl ketone in the liquid phase, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the presence of Raney nickel catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature in the range of from about100 C to about C,
  • a process for preparing eyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone at a temperature of about 100 C. and at a pressure sufiicient to maintain 7 the methyl vinyl ketone in the liquid phase, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the presence of a hydrogenation catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature in the range of from about 100 C. to about 165 C., and separating the resulting cyclohexyl methyl carbinol.
  • a continuous process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone in the vapor phase and below the temperature at which substantial polymerization of the reactants occurs, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the presence of Raney nickel catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature of from about 100 C. to about 165 0., and separating the resulting cyclohexyl methyl carbinol.
  • a continuous process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which'process comprises reacting buta'diene with methyl vinyl ketone in the vapor phase and below the temperature at which substantial polymerization of the reactants occurs, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the resence of a hydrogenation catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature of from about 100 C. to about 165 C., and separating the resulting cyclohexyl methyl carbinol.
  • a continuous process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone in the vapor 8 phase to form cyclohexenyl methyl ketone. and hydrogenating the cyclohexenyl methyl ketone to cyclohexyl methyl carbinol.
  • a process for preparing cyclohexyl methyl carbinol which comprises reacting butadiene with methyl vinyl ketone in the vapor phase to form cyclohexenyl methyl ketone, and hydogenating the cyclohexenyl methyl ketone to cyclohexyl methyl carbinol.
  • a process for preparing a cyclohexyl methyl carbinol which comprises reacting methyl vinyl ketone with a conjugated diolefin in the vapor phase to form a cyclohexenyl methyl ketone, and hydrogenating the cyclohexenyl methyl ketone to a cycohexyl methyl carbinol.

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Description

Patented Feb. 3, 1948 CYCLIC ALconoLs Arm 'rnnm PREPARATION Rupert 0. Morris,
Evans, Oakland, .CallL,
,velopinent Company, S corporation of Delaware Berkeley, and Theodore W.
asslgnors to Shell Dean Francisco, Calif., a
No Drawing. Application April 30, 1942,
sci-a1 No. 441,245
s Claims. (cl. 280-617) This invention relates to the production of a1 cohols containing a carbocyclic radical attached to the carbinol group. More particularly, the invention relates to the preparation of saturated alcohols containing a monoor polycarbocyclic radical attached to the carbinol group. These alcohols which may be represented by the general formula:
on 11-04 thew-den R- -n n R -a z-methyLfl-ahydroxy ethyl, bicyclo (2,2,1) heptane, a compound produced by the process of the present invention from cyclopentadiene and methyl isopropenyl ketone.
The process of the invention comprises the condensation of cyclic and/or acyclic polyolefinic by drocarbons with cyclic and/or acyclic olefinic carbonylic compounds to produce aldehydes or ketones containing an unsaturated carbocyclic radical directly attached to the carbonyl group; and/or the hydrogenation of such unsaturated carbocyclic-substituted aldehydes or ketones to produce the corresponding saturated carbocyclicsubstituted alcohols represented by the first formula of paragraph 1; and/or the further hydrogenation of the saturated carbocyclic-substituted aldehydes or ketones of the type derived by hydrogenation of the products step to produce the corresponding saturated carbocyclic-substitutedalcohols (i. e. the same products as produced in accordance with the first hydrogenation step).
applicable, for example, to the production or cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone and/or from cyclohexenyl ,m'ethyl ketone. Similarly, hexahydro phenyl carbinol may be obtained from butadiene and acrolein and/or from tetrahydro benzaldehyde.
The alcohols containing a saturated carbocyclic radical attached to the carbinol group and prepared in accordance with the process of the invention are valuable solvents, intermediate or starting materials for chemical synthesis as well as useful for many other purposes such as insecticides, plasticizers, drugs, perfumes, etc. Hitherto such alcohols, particularly the secondary alcohols as are here obtained-from an afiolefinic ketone and a conjugated diolefln, have been obtained in the laboratory through the Grignard reaction or by the hydrogenation of the corresponding aromatic compounds (as cyclohexylmethylcarbinol from acetophenone) which procedures have produced yields considerably less than the theoretical amount as well as giving various by-products. Also, the prior art on the condensation of such diolefins as butadiene with olefinic alkyl ketones such as methyl vinyl ketone, teaches the use of a solvent, an emulsifying agent, an oxidizing agent, a catalyst, a reaction time" of several days and a temperature below the boiling point of the olefinic alkyl ketone. By the present process all of these requirements are obviated. In addition,
, the employment of aryl and aralkyl ketones, of
of the condensation the type herein described, in the Diels-Alder condensation reaction is new as well as the substances produced by this condensation and-by the hydrogenation of these condensation compounds. The latter are novel and useful compounds suitabie for such uses as suggested above,
It is accordingly an object of the present invention to overcome the afore-mentioned defects of the prior art and to produce carbocyclic-substituted alcohols of the type above described in high yield, purity and/or in a continuous procedure, from cyclic and acyclic polyolefinic hydrocarbons together with cyclic and acyclic olefinic carbonylic compounds by processes of condensation and hydrogenation. Other objects are to produce the aforementioned carbocyclic-substituted alcohols in high yield and purity by hydrogenation of the corresponding carbonylic compounds containing a saturated or unsaturated carbocyclic radical attached to the carbonyl carbon atom. Still another object is the production of novel' compositions of matter. Other objects and advantages will be apparent from the follow- The process is particularly ingdescription.
It has now been found that polyoleflnic hydrocarbons (particularly conjugated diolefins) and oleflnic carbonylic compounds (in particular those laflolefinic ketones and aldehydes] in which a double bond carbon atom is attached by a single bond to the carbonyl carbon atom) can-be made to condense in high yield to produce carbonylic compounds containing an unsaturated carbocyclic radical attached to the carbonyl carbon atom by effecting the reaction above the atmospheric boiling point of one of the reactants, such as the reacting ketone, and, if desired under superatmospheric pressure, contrary to the teachings of the prior art. That is, the ketone or aldehyde may be reacted in the vapor phase or, if in the liquid phase, at a temperature above its normalboiling point and under pressure sufficient at least to maintain it in the liquid phase. The condensation takes place as illustrated by the equation M R v /i Edi-R R (I? wherein each R is a cycloalkyl, alkaryl, aryl or aralkyl radical (which may be further substituted). The reacting diolecfin may likewise be a cyclic compound of the type described, in which case a bicyclic aldehyde or ketone is produced, such as the 2-methyl, 2-a-hydroxy ethyl, bicyclo (2,2,1) heptane, supra.
It has also been found that much greater yields of the desired ketones and aldehydes containing an unsaturated carbocyclic radical attached to the carbonyl carbon atom, are obtained in a much shorter time in this manner than by the procedure taught in the prior art as exemplified by U. S. Patent 2,222,357, wherein the condensation of butadiene with methyl vinyl ketone is carried out at a temperature of about 50 C. and below 80 C. (which is the boiling point of methyl vinyl ketone at atmospheric pressure), and requires a solvent, an emulsifying agent, an oxidizing agent and a catalyst as well as requiring four days or longer for substantial completion.
The temperature and reaction time for this condensation step should be regulated with respect to each other. For a higher temperature, a shorter reaction period will elfect the same degree of completeness of the reaction as will a lower hydrogen atom or an alkyl,
temperature with a longer reaction time. The
upper temperature limit is, in general, that at which substantial polymerization of the reacting material or product takes place, For instance, with methyl vinyl ketone, the dimer may be formed in considerable amount at temperatures not substantially in excess of about 250 C. and at this temperature the reaction of methyl vinyl ketone with butadiene may reach substantial completion in approximately 30 seconds. At 100 C., on the other hand, the same reaction may require an hour and a half or more. The condensation reaction may also be promoted by increased pressure.
This condensation step may be carried out in batch, intermittent or continuous manner. If a continuous mode of operation is desired, this may be conveniently accomplished, for example,
by effecting the reaction in the vapor phase and at or near ordinary atmospheric pressure. If operation in a batch or intermittent manner is wanted, this may conveniently be accomplished by confining the unsaturated aldehyde or ketone and the polyolefin in a suitable chamber such as an autoclave and applying a temperature commensurate with the reaction time and pressure as indicated above. If the gaseous reactants are charged to a reaction vessel equipped with a pressure indicator, the progress of the reaction can be gauged by the decrease in pressure since the condensation step is essentially a union of two molecules to form one molecule with a consequent reduction of the vapor pressure in the reactor.
Intimate commingling of the reactants in the execution of the condensation step is desirable. This may be effected, if one or more of the reactants are in the liquid phase, by shaking, stirring or other suitable means; or if the process is being carried out in a continuous vapor phase manner, the gases may be passedthrough reaction tubes or chambers packed with an inert substance such as quartz chips, glass wool, porcelain chips, Raschig rings of noncatalytic material and the like which'also act by way of efiecting a more uniform heat transfer in the reaction space, mini- 'mizing spots of extreme temperature, etc. The essential apparatus, namely, the reaction tube or chambers, obviously may be of widely varying design, care being taken, however, to fabricate it of material which will not catalyze the polymerization or decomposition 'of the reactants or products.
Since the two components condense in equimolecular proportions, they may be brought together in approximately this ratio, although this is not essential for their reaction, This condensation step of the process is further illustrated by the following:
Example I In an autoclave was placed 1.0 mol g.) of methyl vinyl ketone and 1.1 mols of butadiene (59 g.). The material was heated for 1.5 hours at 100 C. and then fractionated. cyclohexenyl methyl ketone, boiling at 100-101 at 50 mm., was obtained in better than yield.
Analysis calculated for CsHmO: C,'77.4; H, 9.68; Br. No., 129. Found: C, 76.9; H, 9.77; Br. No., 126; d4, 0.9535; u 1.4696.
It has further been found, according to the process of the present invention, that the carbonylic compound which contains an unsaturated carbocyclic radical attached to the carbonyl carbon atom, and which is formed by the above condensation can be selectively hydrogenated in high yield, under carefully controlled conditions as herein described, to produce first the corresponding saturated carbocyclic-substituted ketone or aldehyde and then the corresponding saturated carbocyclic-substituted alcohol. If an aldehyde is employed in the condensation, the hydrogenated product will be a primary alcohol; if a ketone is employed, the hydrogenated product will be a secondary alcohol.
The hydrogenation procedure to produce the saturated carbocyclic-substituted alcohol is carried out at a relatively high pressure. For example, to obtain cyclohexylmethyl carbinol in high yield from cyclohexylmethyl ketone or from cyclohexenyl methyl ketone, a hydrogen pressure of from about 40 to about atmospheres is employed, whereas in hydrogenating cyclohexenyl methyl ketone to cyclohexyl methyl ketone a hytadiene-l,3;
drogen pressure of only genated in the liquid phase, a solvent may be used for convenience, such as an alcohol, ester, ether and/or a saturated hydrocarbon, although the reaction does not depend on this solvent and may, as in the continuous, consecutive vapor condensation and hydrogenation procedure, be carried on entirely in the vapor phase, the hydrogenation being effected in a further section of the reaction tube or chamber wherein the condensation is taking place. The temperature employed for this higher pressure range is from about 165 C. to about 100C the necessary temperature decreasing accordingly to correspond with increased pressure. The optimum reaction conditions, of course, may vary for individual compounds.
A hydrogenation catalyst is conveniently employed to accelerate the reaction. Any of the hydrogenation catalysts known to the art may be utilized with varying degrees of effectiveness. Of those which are especially adapted for such work, Raneys nickel and Adkins copper-chromium oxide are very eflicacious from the viewpoint of both cost and efflciency. Other suitable hydrogenation catalysts are those consisting of or comprising one or more metals, or catalytically active compounds of metals such as Fe, Co, Cu, Pd, Zr, Ti, Th, V, Ta, Ag, Mo, Al and the like. This hydrogenation step of the process is further illustrated by the following:
Example II 414 g. of cyclohexenyl methyl ketone prepared as shown in Example I, was placed in a high pressure hydrogenation apparatus together with approximately 5 g. of Raney nickel catalyst per mol of cyclohexenyl methyl ketone. The vessel was heated to 165 C. and the hydrogen pressure raised to 40 atmospheres. After completion of the hydrogenation, there was obtained 380 g, of cyclohexyl methyl carbinol boiling at 108-9 at 50 mm., and at 812 at mm. 1
Analysis calculated for CaHreO: C, 75.0; H, 12.5; acetyl value, 0.78. Found: C, 75.1; H, 12.5; acetyl value, 0.72; (14 0.925; n 1.4654.
The polyolefins employed as the starting material according to the present invention, of which the conjugated diolefins are a preferred group, may be such compounds as butadiene-1,3 (bivinyl), isoprene (2-methylbutadiene-1,3) chloroprene (2-chlorbutadiene-l,3), pentadiene-1,3 (piperylene), 2-ethylbutadiene-1,3; Z-haloethylbutadiene-1,3; 2,3-Mez-butadiene-L3 (methylisoprene); 1,4-Mez-butadiene-L3; 2,3-dihalobu- 2,3-halo ethyl halobutadiene,1,3; iuran, cyclopentadiene, cyclohexadiene, anthracene, thiophene, pyrrole, iulvenes, a and B terpinene, a and ,8 phellandrene, mycene and the like, their analogues, homologues and suitable substituted derivatives.
The unsaturated carbonylic compounds utilized as the starting material to condense with the above polyolefins, according to the process of the present invention, of which the up olefinic carbonylic compounds are a preferred class, are such compounds as acrolein, oz methacrolein, or ethyl acrolein, a propyl acrolein, crotonaldehyde, tiglic pound, preferably aldehyde, p-methyl-crotonaldehyde, up dimethylcrotonic aldehyde, cltral, nonadiene-(2,6) -al-(1) methyl vinyl ketone (methylene acetone), methyl isopropenyl ketone, artemesia ketone, vinyl phenyl ketone, propenyl phenyl ketone, methyl cinnamyl ketone, distyryl-ketone, styryl phenyl ketone, ethyl cinnamyi ketone and the like, their analogues, homologues and suitable substituted derivatives.
The principal steps of the present process may be summarized as follows:
1. The condensation of a. polyolefinic coma conjugated diolefln such as butadiene-1,3, with an olefinic carbonylic compound, preferably an alpha, beta, oleflnic aldehyde or ketone such as methyl vinyl ketone, to form an aldehyde or ketone which contains an unsaturated carbocyclic radical attached to the carbonyl carbon atom, such as cyclohexenyl methyl ketone, in high yield, by effecting the reaction either with both reactants in the vapor phase or with one of the reactants, as, for instance, the ketone, at a temperature above its normal boiling point but under suilicient pressure to maintain it in the liquid phase.
2. The selective hydrogenation of the unsaturated carbocyclic-substituted carbonylic compound produced in the above step, or the further hydrogenation of an aldehyde or ketone having a saturated carbocyclic radical attached to the carbonyl carbon atom to produce the corresponding saturated carbocyclic-substituted alcohol, such as cyciohexyl methyl carbinol, in high yield, this hydrogenation step being effected with the carbonylic compound either in the vaporor liquid phase.
3. The process of consecutively eifecting the 'above two steps in the order given as, for instance, by carrying out both the condensation and hydrogenation steps in either the vapor or liquid phase in successive sections of the apparatus in a continuous manner.
This application is a continuation-in-part of our copending application, Serial No. 434,114, filed March 10, 1942, now abandoned.
We claim as our invention:
1. A process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone at a temperature or about 100 C. and at a pressure sufllcient to maintain the methyl vinyl ketone in the liquid Phase, re-
. acting the resulting cyclohexenyl methyl ketone with hydrogen in the presence of Raney nickel catalyst at a pressure of about 40 atmospheres and at a temperature of about 165 0., and sepa-- rating the resulting cyclohexyl methyl carbinol.
2. A process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone at a temperature or about C. and at a pressure suflicient to maintain the methyl vinyl ketone in the liquid phase, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the presence of Raney nickel catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature in the range of from about100 C to about C,
and separating the resulting cyclohexyl methyl carbinol 3. A process for preparing eyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone at a temperature of about 100 C. and at a pressure sufiicient to maintain 7 the methyl vinyl ketone in the liquid phase, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the presence of a hydrogenation catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature in the range of from about 100 C. to about 165 C., and separating the resulting cyclohexyl methyl carbinol.
4. A continuous process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone in the vapor phase and below the temperature at which substantial polymerization of the reactants occurs, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the presence of Raney nickel catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature of from about 100 C. to about 165 0., and separating the resulting cyclohexyl methyl carbinol.
5. A continuous process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which'process comprises reacting buta'diene with methyl vinyl ketone in the vapor phase and below the temperature at which substantial polymerization of the reactants occurs, reacting the resulting cyclohexenyl methyl ketone with hydrogen in the resence of a hydrogenation catalyst at a pressure of about 40 atmospheres to about 100 atmospheres and at a temperature of from about 100 C. to about 165 C., and separating the resulting cyclohexyl methyl carbinol.
6. A continuous process for preparing cyclohexyl methyl carbinol from butadiene and methyl vinyl ketone which process comprises reacting butadiene with methyl vinyl ketone in the vapor 8 phase to form cyclohexenyl methyl ketone. and hydrogenating the cyclohexenyl methyl ketone to cyclohexyl methyl carbinol.
7. A process for preparing cyclohexyl methyl carbinol which comprises reacting butadiene with methyl vinyl ketone in the vapor phase to form cyclohexenyl methyl ketone, and hydogenating the cyclohexenyl methyl ketone to cyclohexyl methyl carbinol.
8 A process for preparing a cyclohexyl methyl carbinol which comprises reacting methyl vinyl ketone with a conjugated diolefin in the vapor phase to form a cyclohexenyl methyl ketone, and hydrogenating the cyclohexenyl methyl ketone to a cycohexyl methyl carbinol.
, RUPERT C. MORRIS. THEODORE W. EVANS.
REFERENCES CITED The following references are-of record in the file of this patent:
UNITED STATES PATENTS OTHER REFERENCES Sabatier, Comptes Ren'dus, 139, pages 345 et q.
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Cited By (14)

* Cited by examiner, † Cited by third party
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US2597842A (en) * 1950-05-09 1952-05-27 Universal Oil Prod Co Cyclic carbinols
US2694730A (en) * 1951-10-02 1954-11-16 Universal Oil Prod Co Derivatives of bicyclooctene hydrocarbons and production thereof
US2862026A (en) * 1953-08-06 1958-11-25 Ruhrchemie Ag Isomeric derivatives of monocyclic diolefinic terpenes
US2894983A (en) * 1957-02-23 1959-07-14 Asta Werke Ag Chem Fab Succinic acid esters
US3225102A (en) * 1960-12-13 1965-12-21 Eastman Kodak Co Allenic aldehydes
US3487102A (en) * 1966-08-22 1969-12-30 Int Flavors & Fragrances Inc Process for preparing alpha,3,3 - trimethyl cyclohexane methyl alkanoates
US3514489A (en) * 1967-09-05 1970-05-26 Int Flavors & Fragrances Inc Sec-butyl cyclohexane carboxaldenhydes
US3859324A (en) * 1972-08-03 1975-01-07 Universal Oil Prod Co Process for the preparation of alkaline sulfate esters of n-alkyl-substituted hydroxypolyalkoxymethylcyclohexenes
US3867421A (en) * 1972-08-03 1975-02-18 Universal Oil Prod Co Biodegradable sulfate detergents
US4153811A (en) * 1977-02-04 1979-05-08 International Flavors & Fragrances Inc. Hydroxy alkenyl norbornane derivatives
US4181631A (en) * 1975-02-12 1980-01-01 Givaudan Corporation Alpha-hydroxyalkyl-4-tertiary-alkylcyclohexane perfume compositions
US4549982A (en) * 1984-08-24 1985-10-29 International Flavors & Fragrances Inc. 1-Oxoalkyl-2-isopropylnorbornane derivatives, uses thereof in augmenting or enhancing the aroma of consumable materials and processes for preparing same
US20150011810A1 (en) * 2011-09-07 2015-01-08 United States Of America As Represented By The Secretary Of The Navy High Density Cyclic Fuels Derived From Linear Sesquiterpenes
US9963405B1 (en) 2009-07-29 2018-05-08 The United States Of America As Represented By The Secretary Of The Navy High density cyclic fuels derived from linear sesquiterpenes

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GB476189A (en) * 1936-06-26 1937-12-03 George William Johnson Improvements in the manufacture and production of secondary, mixed aliphatic-cyclic alcohols
US2197462A (en) * 1937-12-27 1940-04-16 Shell Dev Process and product relating to heteropolar compounds
US2198375A (en) * 1938-12-08 1940-04-23 Rohm & Haas Higher polyalkylated cyclohexyl derivative
US2222357A (en) * 1939-02-25 1940-11-19 Wingfoot Corp Tetrahydro aryl-alkyl ketones and method for preparing them
US2230005A (en) * 1938-01-04 1941-01-28 Shell Dev Process for the production of valuable products from cracked petroleum distillates
US2275752A (en) * 1938-11-25 1942-03-10 Ciba Pharm Prod Inc Cyclic condensation products and process of making same

Patent Citations (6)

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Publication number Priority date Publication date Assignee Title
GB476189A (en) * 1936-06-26 1937-12-03 George William Johnson Improvements in the manufacture and production of secondary, mixed aliphatic-cyclic alcohols
US2197462A (en) * 1937-12-27 1940-04-16 Shell Dev Process and product relating to heteropolar compounds
US2230005A (en) * 1938-01-04 1941-01-28 Shell Dev Process for the production of valuable products from cracked petroleum distillates
US2275752A (en) * 1938-11-25 1942-03-10 Ciba Pharm Prod Inc Cyclic condensation products and process of making same
US2198375A (en) * 1938-12-08 1940-04-23 Rohm & Haas Higher polyalkylated cyclohexyl derivative
US2222357A (en) * 1939-02-25 1940-11-19 Wingfoot Corp Tetrahydro aryl-alkyl ketones and method for preparing them

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2597842A (en) * 1950-05-09 1952-05-27 Universal Oil Prod Co Cyclic carbinols
US2694730A (en) * 1951-10-02 1954-11-16 Universal Oil Prod Co Derivatives of bicyclooctene hydrocarbons and production thereof
US2862026A (en) * 1953-08-06 1958-11-25 Ruhrchemie Ag Isomeric derivatives of monocyclic diolefinic terpenes
US2894983A (en) * 1957-02-23 1959-07-14 Asta Werke Ag Chem Fab Succinic acid esters
US3225102A (en) * 1960-12-13 1965-12-21 Eastman Kodak Co Allenic aldehydes
US3487102A (en) * 1966-08-22 1969-12-30 Int Flavors & Fragrances Inc Process for preparing alpha,3,3 - trimethyl cyclohexane methyl alkanoates
US3514489A (en) * 1967-09-05 1970-05-26 Int Flavors & Fragrances Inc Sec-butyl cyclohexane carboxaldenhydes
US3867421A (en) * 1972-08-03 1975-02-18 Universal Oil Prod Co Biodegradable sulfate detergents
US3859324A (en) * 1972-08-03 1975-01-07 Universal Oil Prod Co Process for the preparation of alkaline sulfate esters of n-alkyl-substituted hydroxypolyalkoxymethylcyclohexenes
US3907856A (en) * 1972-08-03 1975-09-23 Universal Oil Prod Co Biodegradable sulfate detergents
US3939197A (en) * 1972-08-03 1976-02-17 Universal Oil Products Company Process for the preparation of alkaline sulfate esters of N-alkyl-substituted hydroxypolyalkoxymethylcyclohexenes
US4181631A (en) * 1975-02-12 1980-01-01 Givaudan Corporation Alpha-hydroxyalkyl-4-tertiary-alkylcyclohexane perfume compositions
US4153811A (en) * 1977-02-04 1979-05-08 International Flavors & Fragrances Inc. Hydroxy alkenyl norbornane derivatives
US4549982A (en) * 1984-08-24 1985-10-29 International Flavors & Fragrances Inc. 1-Oxoalkyl-2-isopropylnorbornane derivatives, uses thereof in augmenting or enhancing the aroma of consumable materials and processes for preparing same
US9963405B1 (en) 2009-07-29 2018-05-08 The United States Of America As Represented By The Secretary Of The Navy High density cyclic fuels derived from linear sesquiterpenes
US9963651B1 (en) 2009-07-29 2018-05-08 The United States Of America As Represented By The Secretary Of The Navy High density cyclic fuels derived from linear sesquiterpenes
US9963652B1 (en) 2009-07-29 2018-05-08 The United States Of America As Represented By The Secretary Of The Navy High density cyclic fuels derived from linear sesquiterpenes
US20150011810A1 (en) * 2011-09-07 2015-01-08 United States Of America As Represented By The Secretary Of The Navy High Density Cyclic Fuels Derived From Linear Sesquiterpenes
US9493717B2 (en) * 2011-09-07 2016-11-15 The United States Of America As Represented By The Secretary Of The Navy High density cyclic fuels derived from linear sesquiterpenes

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