US2309664A - Method of preparing guanamines - Google Patents
Method of preparing guanamines Download PDFInfo
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- US2309664A US2309664A US2309664DA US2309664A US 2309664 A US2309664 A US 2309664A US 2309664D A US2309664D A US 2309664DA US 2309664 A US2309664 A US 2309664A
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- US
- United States
- Prior art keywords
- biguanide
- guanamines
- parts
- glycerides
- solution
- Prior art date
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 42
- 125000005456 glyceride group Chemical group 0.000 description 30
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N diguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 28
- 238000006243 chemical reaction Methods 0.000 description 26
- VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 description 20
- BVDRUCCQKHGCRX-UHFFFAOYSA-N 2,3-dihydroxypropyl formate Chemical compound OCC(O)COC=O BVDRUCCQKHGCRX-UHFFFAOYSA-N 0.000 description 18
- 150000001298 alcohols Chemical class 0.000 description 18
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 16
- 239000002253 acid Substances 0.000 description 16
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 16
- 239000003795 chemical substances by application Substances 0.000 description 14
- 235000014113 dietary fatty acids Nutrition 0.000 description 14
- 239000000194 fatty acid Substances 0.000 description 14
- 150000004665 fatty acids Chemical class 0.000 description 14
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 14
- 125000001931 aliphatic group Chemical group 0.000 description 12
- 150000004703 alkoxides Chemical class 0.000 description 12
- 150000004283 biguanides Chemical class 0.000 description 12
- 150000002148 esters Chemical class 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 229940058933 biguanide antimalarials Drugs 0.000 description 10
- 229940090145 biguanide blood glucose lower drugs Drugs 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- LRHPLDYGYMQRHN-UHFFFAOYSA-N n-butanol Chemical group CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- VHUUQVKOLVNVRT-UHFFFAOYSA-N ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 8
- 239000000908 ammonium hydroxide Substances 0.000 description 8
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 230000000875 corresponding Effects 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical group C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 6
- 239000012458 free base Substances 0.000 description 6
- 238000002844 melting Methods 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 238000001953 recrystallisation Methods 0.000 description 6
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 6
- 229910052708 sodium Inorganic materials 0.000 description 6
- 239000011734 sodium Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- -1 alcohol ester Chemical class 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- 150000002430 hydrocarbons Chemical class 0.000 description 4
- 239000002198 insoluble material Substances 0.000 description 4
- 239000000944 linseed oil Substances 0.000 description 4
- 235000021388 linseed oil Nutrition 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- WQDUMFSSJAZKTM-UHFFFAOYSA-N sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- ODZPKZBBUMBTMG-UHFFFAOYSA-N Sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 2
- XHODMTAOVMFHQJ-UHFFFAOYSA-N aluminum;propan-2-ol Chemical compound [Al].CC(C)O XHODMTAOVMFHQJ-UHFFFAOYSA-N 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N carbodiimide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 150000001805 chlorine compounds Chemical class 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- HHFAWKCIHAUFRX-UHFFFAOYSA-N ethoxide Chemical compound CC[O-] HHFAWKCIHAUFRX-UHFFFAOYSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000007429 general method Methods 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 2
- 239000012046 mixed solvent Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006011 modification reaction Methods 0.000 description 2
- AMQJEAYHLZJPGS-UHFFFAOYSA-N n-pentanol Chemical compound CCCCCO AMQJEAYHLZJPGS-UHFFFAOYSA-N 0.000 description 2
- 239000005445 natural product Substances 0.000 description 2
- 229930014626 natural products Natural products 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- CUQCMXFWIMOWRP-UHFFFAOYSA-N phenyl biguanide Chemical compound NC(N)=NC(N)=NC1=CC=CC=C1 CUQCMXFWIMOWRP-UHFFFAOYSA-N 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000001376 precipitating Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000000344 soap Substances 0.000 description 2
- 239000011877 solvent mixture Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
Definitions
- This invention relates to a method of pre paring guanamines and more particularly guanamines substituted on the Z-carbon atom of the triazine ring by a relatively long aliphatic radical.
- Guanamines having long aliphatic substituents on the 2,-carbon atom of the triazine ring have achieved importance since by reaction with formaldehyde they can be used in textile finishes.
- esters of lower monohydric alcohols gave much better results than the higher molecular alcohol ester. I have found, however, that contrary to what had been assumed, good results can be obtained by reacting glycerides of fatty acids with biguanide using the same type of metal alkoxide catalyst or condensation agent. Since glycerine is a polyhydric alcohol, the esters are of high molecular weight, and although in general are far less reactive in most reactions than are the corresponding esters of monohydric alcohols, they are, however, the cheapest source of most fatty acids and represent, therefore, a rawmaterial of great economic importance which hitherto had been considered unsuitable for the production of guanamines.
- the present invention is applicable to all glycerides of aliphatic acids. However, the economic importance is much greater in the case of the long chain glycerides because these are the compounds that are normally obtained in nature and present the greatest economic advantages. Therefore, while the invention is not limited to the use of glycerides of higher fatty acids, these constitute the preferred embodiment.
- glycerides are obtained in nature in the form of mixtures. In fact it is the exception to find in nature a pure glyceride of a single fatty acid. It is an advantage of the present invention that the process is applicable not only to pure glycerides of a single fatty acid, but also to mixtures. This permits the use of the cheap mixed glycerides that are obtainable from natural products and greatly reduces the cost of producing guanamines. In some cases where it may be desirable to have a certain proportion, partial separation of the glycerides may be effected whereby fractions differing in one or other of the components are obtained. The extreme flexibility of the process with regard to raw materials makes it possible to obtain guanamines of various physical properties from cheap raw materials.
- the guanamines of the present invention it is not necessary to use biguanide itself, but substituted biguanides such as phenyl biguanide, allyl biguanide, dimethyl biguanide, and the like may be used, in which case the corresponding N-substituted guanamines are produced.
- substituted biguanides such as phenyl biguanide, allyl biguanide, dimethyl biguanide, and the like
- the most important 2-alkyl substituted guanamines of the present invention are those prepared with unsubstituted biguanide in which case the two amino groups in the 4- and fi-positions of the triazine ring are free, and in a more specific aspect these are the preferred compounds of the present invention.
- the reaction of glycerides with biguanide and particularly with substituted biguanides is too slow in most cases to be economically practical and therefore it is desirable to use a condensing agent.
- the best condensing agents are the metal alkoxides and the compounds which in alcohol solutions will yield alkoxides. Typical compounds are sodium methoxide, ethoxide, aluminum isopropoxide, sodamide, and the like.
- alkoxide or other basic condensing agent will vary to some extent with different glycerides. In general it has been found that it is ordinarily desirable to use somewhat less of the alkoxide than that corresponding to stoichiometrical equivalents, whereas in the case of esters of monohydric alcohols it is usually desirable to use stoichiometrical equivalents.
- a large amount of the condensing agent reacts with some of the glyceride producing a soap which is not very soluble in the solvent mixture and which if present in excess amounts tends to be precipitated and interfere with the recovery of the guanamine.
- Biguanide and substituted biguanides may be dispersed in the glyceride where the latter is a liquid, but in general it is preferable to use a solvent.
- the present invention is not limited to any particular solvent, but I have found that the liquid monohydric alcohols are very effective and cheap and are therefore preferred.
- the choice of alcohol is aiiected to some extent by the glyceride used.
- the lower monohydric alcohols such as ethanol and methanol are excellent solvents for biguanide and substituted biguanides. However, they do not show as high a solubility for some of the glycerides notably the saturated glycerides.
- Example 1 parts of biguanide and 50 parts of olive oil are dissolved in about 2'75 parts of ethanol containing 2.3 parts of sodium, and the solution allowed to stand. After several days the solution is filtered and the solid discarded. The filtrate is treated with excess sulfuric acid and the guanamine sulfate which precipitates is washed with water. The free guanamine base is prepared by treatment with alcohol containing ammonium hydroxide and 12 parts of the product having a melting point of 83 is obtained. On recrystallization the product gives a melting point of 87 C.
- Example 2 10 parts of biguanide and 50 parts of linseed oil are dissolved in a mixture of 50 arts of butanol and 80 parts of methanol and refluxed for 12 /2 hours. A small amount of insoluble material is filtered off and an excess of sulfuric acid added. The mixture is then heated to about 80 C., filtered, and cooled to precipitate guanamine sulfate. The free guanamine base is obtained by dissolving the sulfate in about 70 parts of hot ethanol, adding an excess of ammonium hydroxide, and precipitating the free base by dilution with water. A yield of the product is obtained which on recrystallization from acetone has a melting point of 106 C.
- Example 3 10 parts of biguanide and 50 parts of linseed oil are dissolved in about parts of butanol containing .23 part of sodium and the solution allowed to stand at room temperature for three days. The solution is then made acid by the addition of sulfuric acid, heated to boiling and the insoluble material filtered off. Guanamine sulfate crystallizes out on cooling, is filtered off and the free base obtained by treatment with alcohol solution containing ammonium hydroxide. The yield was 41 of theory.
- Example 4 10 parts of biguanide is dissolved in about 90 parts of methanol containing .23 part of sodium and this solution is added to a solution of 50 parts of a hydrogenated glyceride in 200 parts of toluene. The mixture is stirred for 1 /2 days, treated with excess sulfuric acid, and the precipitated guanamine sulfate washed with toluene. The sulfate is recrystallized from 450 parts ethanol yielding 25 parts of the pure guanamine sulfate. The free base is prepared by treatment with alcohol containing ammonium hydroxide and the desired product obtained by dilution with water. After recrystallization from acetone it melts at C.
- a method of preparing 2-substituted guanamines which comprises reacting a biguanide with a glyceride of an aliphatic acid.
- a method of preparing 2-substituted guanamines which comprises reacting biguanide with a'glyceride of an aliphatic acid.
- a method of preparing a long chain 2-substituted guanamine which comprises reacting a biguanide with a glyceride of a long chain aliphatic acid.
- a method of preparing a long chain 2-substituted guanamine which comprises reacting biguanide with a glyceride of a long chain aliphatic acid.
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Patented Feb. 2, 1943 METHOD OF PREPARING GUANAMINES Wilbur Null Oldham, Old Greenwich, Conn, as-
signor to American Cyanamid Company, New York, N. Y., a corporation of Maine No Drawing. Application August 30, 1941, Serial No. 409,150
12 Claims.
This invention relates to a method of pre paring guanamines and more particularly guanamines substituted on the Z-carbon atom of the triazine ring by a relatively long aliphatic radical.
Guanamines having long aliphatic substituents on the 2,-carbon atom of the triazine ring have achieved importance since by reaction with formaldehyde they can be used in textile finishes.
In the past it has been proposed to prepare guanamines and particularly long-chain guanamines by two general methods. The first involved reaction of biguanide or substituted biguanides with an acid chloride of the corresponding aliphatic acid. This process works smoothly and gives good yields in many cases but is open to the disadvantage that the acid chlorides are relatively expensive reagents. The second process involved the reaction of esters of fatty acids with lower monohydric alcohols. This process is also capable of giving good yields when a'suitab-le condensation agent is employed such as a metal alkoxide but again the esters of the fatty acids and monohydric alcohols are relatively expensive. It had been thought that the esters of lower monohydric alcohols gave much better results than the higher molecular alcohol ester. I have found, however, that contrary to what had been assumed, good results can be obtained by reacting glycerides of fatty acids with biguanide using the same type of metal alkoxide catalyst or condensation agent. Since glycerine is a polyhydric alcohol, the esters are of high molecular weight, and although in general are far less reactive in most reactions than are the corresponding esters of monohydric alcohols, they are, however, the cheapest source of most fatty acids and represent, therefore, a rawmaterial of great economic importance which hitherto had been considered unsuitable for the production of guanamines.
I do not know why the glycerides react as effectively as they do in spite of their normally lower reactivity and the present invention is not intended to be limited to any theory of action.
The present invention is applicable to all glycerides of aliphatic acids. However, the economic importance is much greater in the case of the long chain glycerides because these are the compounds that are normally obtained in nature and present the greatest economic advantages. Therefore, while the invention is not limited to the use of glycerides of higher fatty acids, these constitute the preferred embodiment.
Many glycerides are obtained in nature in the form of mixtures. In fact it is the exception to find in nature a pure glyceride of a single fatty acid. It is an advantage of the present invention that the process is applicable not only to pure glycerides of a single fatty acid, but also to mixtures. This permits the use of the cheap mixed glycerides that are obtainable from natural products and greatly reduces the cost of producing guanamines. In some cases where it may be desirable to have a certain proportion, partial separation of the glycerides may be effected whereby fractions differing in one or other of the components are obtained. The extreme flexibility of the process with regard to raw materials makes it possible to obtain guanamines of various physical properties from cheap raw materials.
In carrying out the preparation of the guanamines of the present invention it is not necessary to use biguanide itself, but substituted biguanides such as phenyl biguanide, allyl biguanide, dimethyl biguanide, and the like may be used, in which case the corresponding N-substituted guanamines are produced. However, the most important 2-alkyl substituted guanamines of the present invention are those prepared with unsubstituted biguanide in which case the two amino groups in the 4- and fi-positions of the triazine ring are free, and in a more specific aspect these are the preferred compounds of the present invention.
The reaction of glycerides with biguanide and particularly with substituted biguanides is too slow in most cases to be economically practical and therefore it is desirable to use a condensing agent. The best condensing agents are the metal alkoxides and the compounds which in alcohol solutions will yield alkoxides. Typical compounds are sodium methoxide, ethoxide, aluminum isopropoxide, sodamide, and the like.
The optimum amount of alkoxide or other basic condensing agent will vary to some extent with different glycerides. In general it has been found that it is ordinarily desirable to use somewhat less of the alkoxide than that corresponding to stoichiometrical equivalents, whereas in the case of esters of monohydric alcohols it is usually desirable to use stoichiometrical equivalents. When a large amount of the condensing agent is used it reacts with some of the glyceride producing a soap which is not very soluble in the solvent mixture and which if present in excess amounts tends to be precipitated and interfere with the recovery of the guanamine. I do not know whether there is any particular chemical difficulty involved or whether the use of excess condensing agent merely introduces an operational difficulty. It is not intended to limit this modification to any particular theory of action. I believe, however, that at least the primary factor is the operational difficulty produced by the presence of additional solid.
Biguanide and substituted biguanides may be dispersed in the glyceride where the latter is a liquid, but in general it is preferable to use a solvent. The present invention is not limited to any particular solvent, but I have found that the liquid monohydric alcohols are very effective and cheap and are therefore preferred. The choice of alcohol is aiiected to some extent by the glyceride used. The lower monohydric alcohols such as ethanol and methanol are excellent solvents for biguanide and substituted biguanides. However, they do not show as high a solubility for some of the glycerides notably the saturated glycerides. Somewhat higher molecular weight monohydric alcohols show higher solubility for glycerides, for example butyl or amyl alcohol, but are somewhat more expensive. I have found that a very efiective compromise in many cases is to use a mixed solvent having a lower monohydric alcohol such as methanol or ethanol mixed with a suificient amount of a hydrocarbon solvent such as toluene or the like, which confers some additional solubility for some of the saturated glycerides. The solvent is essentially inert in its action and therefore any suitable mixture can be employed preferably using the cheaper alcohols and hydrocarbons.
The invention will be described in greater detail in conjunction with the following specific examples in which the parts are by weight.
Example 1 parts of biguanide and 50 parts of olive oil are dissolved in about 2'75 parts of ethanol containing 2.3 parts of sodium, and the solution allowed to stand. After several days the solution is filtered and the solid discarded. The filtrate is treated with excess sulfuric acid and the guanamine sulfate which precipitates is washed with water. The free guanamine base is prepared by treatment with alcohol containing ammonium hydroxide and 12 parts of the product having a melting point of 83 is obtained. On recrystallization the product gives a melting point of 87 C.
Example 2 10 parts of biguanide and 50 parts of linseed oil are dissolved in a mixture of 50 arts of butanol and 80 parts of methanol and refluxed for 12 /2 hours. A small amount of insoluble material is filtered off and an excess of sulfuric acid added. The mixture is then heated to about 80 C., filtered, and cooled to precipitate guanamine sulfate. The free guanamine base is obtained by dissolving the sulfate in about 70 parts of hot ethanol, adding an excess of ammonium hydroxide, and precipitating the free base by dilution with water. A yield of the product is obtained which on recrystallization from acetone has a melting point of 106 C.
Example 3 10 parts of biguanide and 50 parts of linseed oil are dissolved in about parts of butanol containing .23 part of sodium and the solution allowed to stand at room temperature for three days. The solution is then made acid by the addition of sulfuric acid, heated to boiling and the insoluble material filtered off. Guanamine sulfate crystallizes out on cooling, is filtered off and the free base obtained by treatment with alcohol solution containing ammonium hydroxide. The yield was 41 of theory.
Example 4 10 parts of biguanide is dissolved in about 90 parts of methanol containing .23 part of sodium and this solution is added to a solution of 50 parts of a hydrogenated glyceride in 200 parts of toluene. The mixture is stirred for 1 /2 days, treated with excess sulfuric acid, and the precipitated guanamine sulfate washed with toluene. The sulfate is recrystallized from 450 parts ethanol yielding 25 parts of the pure guanamine sulfate. The free base is prepared by treatment with alcohol containing ammonium hydroxide and the desired product obtained by dilution with water. After recrystallization from acetone it melts at C.
What I claim is:
1. A method of preparing 2-substituted guanamines which comprises reacting a biguanide with a glyceride of an aliphatic acid.
2. A method of preparing 2-substituted guanamines which comprises reacting biguanide with a'glyceride of an aliphatic acid.
3. A method of preparing a long chain 2-substituted guanamine which comprises reacting a biguanide with a glyceride of a long chain aliphatic acid.
4. A method of preparing a long chain 2-substituted guanamine which comprises reacting biguanide with a glyceride of a long chain aliphatic acid.
5. A method according to claim 1 in which the reaction takes place in solution in a lower monohydric alcohol.
6. A method according to claim 2 in which the reaction takes place in solution in a lower monohydric alcohol.
7. A method according to claim 3 in which the reaction takes place in solution in a lower monohydric alcohol.
8. A method according to claim 4 in which the reaction takes place in solution in a lower monohydric alcohol.
9. A method according to claim 1 in which the reaction takes place in solution in an aromatic hydrocarbon.
10. A method according to claim 2 in which the reaction takes place in solution in an aromatic hydrocarbon.
11. A method according to claim 3 in which the reaction takes place in solution in an aromatic hydrocarbon.
12. A method according to claim 4 in which the reaction takes place in solution in an aromatic hydrocarbon.
WILBUR NULL OLDHAM.
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US2309664A true US2309664A (en) | 1943-01-26 |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2426148A (en) * | 1943-10-19 | 1947-08-19 | Hybinette And Cary | Thermal reduction of metals |
US2714057A (en) * | 1951-07-21 | 1955-07-26 | Universal Oil Prod Co | Stabilization of organic compounds |
-
0
- US US2309664D patent/US2309664A/en not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2426148A (en) * | 1943-10-19 | 1947-08-19 | Hybinette And Cary | Thermal reduction of metals |
US2714057A (en) * | 1951-07-21 | 1955-07-26 | Universal Oil Prod Co | Stabilization of organic compounds |
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