US2023160A - Alkyl chloro-dioxy-benzols - Google Patents
Alkyl chloro-dioxy-benzols Download PDFInfo
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- US2023160A US2023160A US715495A US71549534A US2023160A US 2023160 A US2023160 A US 2023160A US 715495 A US715495 A US 715495A US 71549534 A US71549534 A US 71549534A US 2023160 A US2023160 A US 2023160A
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- US
- United States
- Prior art keywords
- chloro
- tertiary
- dioxy
- resorcinol
- benzols
- Prior art date
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- -1 Alkyl chloro-dioxy-benzols Chemical class 0.000 title description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical group C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- SWZVJOLLQTWFCW-UHFFFAOYSA-N 2-chlorobenzene-1,3-diol Chemical compound OC1=CC=CC(O)=C1Cl SWZVJOLLQTWFCW-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229960000443 hydrochloric acid Drugs 0.000 description 4
- 235000011167 hydrochloric acid Nutrition 0.000 description 4
- 235000005074 zinc chloride Nutrition 0.000 description 4
- 239000011592 zinc chloride Substances 0.000 description 4
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 3
- FXNDIJDIPNCZQJ-UHFFFAOYSA-N 2,4,4-trimethylpent-1-ene Chemical group CC(=C)CC(C)(C)C FXNDIJDIPNCZQJ-UHFFFAOYSA-N 0.000 description 2
- PDVFPXQCQJNLKK-UHFFFAOYSA-N 2-chloro-4-pentylbenzene-1,3-diol Chemical group C(CCCC)C1=C(C(=C(O)C=C1)Cl)O PDVFPXQCQJNLKK-UHFFFAOYSA-N 0.000 description 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- AJPXTSMULZANCB-UHFFFAOYSA-N chlorohydroquinone Chemical compound OC1=CC=C(O)C(Cl)=C1 AJPXTSMULZANCB-UHFFFAOYSA-N 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- JQGLYGBRSXVOKT-UHFFFAOYSA-N 2-(2,4,4-trimethylpentan-2-yl)benzene-1,3-diol Chemical compound CC(C)(C)CC(C)(C)C1=C(O)C=CC=C1O JQGLYGBRSXVOKT-UHFFFAOYSA-N 0.000 description 1
- WKOWYEPZBPYVBF-UHFFFAOYSA-N 2-chloro-4-octylbenzene-1,3-diol Chemical group C(CCCCCCC)C1=C(C(=C(O)C=C1)Cl)O WKOWYEPZBPYVBF-UHFFFAOYSA-N 0.000 description 1
- GQKDZDYQXPOXEM-UHFFFAOYSA-N 3-chlorocatechol Chemical compound OC1=CC=CC(Cl)=C1O GQKDZDYQXPOXEM-UHFFFAOYSA-N 0.000 description 1
- YJBHMZTYHIGUOH-UHFFFAOYSA-N 4,6-bis(2-methylpropyl)benzene-1,3-diol Chemical compound CC(C)CC1=CC(CC(C)C)=C(O)C=C1O YJBHMZTYHIGUOH-UHFFFAOYSA-N 0.000 description 1
- NKJILAULCQTPQL-UHFFFAOYSA-N 4-butyl-2-chlorobenzene-1,3-diol Chemical group CCCCC1=CC=C(O)C(Cl)=C1O NKJILAULCQTPQL-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000790917 Dioxys <bee> Species 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- YABPXXOZZZIUBP-UHFFFAOYSA-N phenoxy hypochlorite Chemical class ClOOC1=CC=CC=C1 YABPXXOZZZIUBP-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/245—Halogenated derivatives monocyclic polyhydroxylic containing halogens bound to ring carbon atoms
Definitions
- This invention relates to new alkyl derivatives of chloro-dioxybenzols, characterized by the fact that the alkyl attached to the benzol nucleus is a tertiary alkyl group.
- R1, R2, R3 are alkyl groups, either straight-chained or branched, and the OH groups being either in ortho, in meta, or in para position to each other.
- alkyl chloro-dioxy benzols within the scope of this invention are the tertiary butyl, the tertiary amyl, the tertiary hexyl, the tertiary heptyl, the tertiary octyl, and the tertiary nonyl derivatives of chloro-pyrocatechol, of chlororesorcinol, and of chloro-hydroquinone, respectively.
- the new alkyl chloro-dioxy benzols may be prepared by introducing the chlorine into the corresponding tertiary alkyl dioxy benzol, or by introducing the desired tertiary alkyl group into the chloro-dioXy benzol derivative.
- the compounds of this invention possess especial germicidal and antiseptic activity coupled with relatively low toxicity, which properties may be utilized in the form of various antiseptics, germicidal and prophylactic solutions, jellies, lozenges and other media.
- Example 1 Tetiary butyl chloro-resorcinol ((CH3)3C-C6H2C1(OH)2) may be prepared by the following process: 55 gr. of resorcinol are dissolved in 100 cc. ether, and '74 gr. sulfuryl chloride added dropwise. The temperature of the mixture is gradually raised to C. and maintained for 3 hours, during which time suction is applied to remove the HCl and S02 liberated in the reaction. The temperature is the-n raised to C. and the ether evaporated, leaving chloro-resorcinol. To this are added 50 gr. tertiary butyl alcohol (tri-methyl carbinol) while stirring and then 10 cc.
- tertiary butyl alcohol tri-methyl carbinol
- Example 2.Tertiary amyl chloro-resorcinol ((CH3)2C2H5CC6H2C1(OH)2) may be prepared by the following process: To chloro-resorcinol prepared as in Example 1 from 55 gr. resorcinol are added 50 gr. tertiary amyl alcohol (di-methyl ethyl carbinol) and 10 cc. concentrated hydro chloric acid and the mixture heated to 100 C. 5 Then 30 gr. anhydrous zinc chloride are gradually added, and heating is continued for 2 hours.
- Example 3.-Tertiary amyl chloro-hydroquinone may be prepared by the following procedure: 28 gr. chloro-hydroquinone, 25 gr. tertiary amyl alcohol (dimethyl ethyl carbinol) and 12 gr. anhydrous zinc chloride are heated together with stirring to about 95 C. and when all is in solution 5 cc. concentrated hydrochloric acid are added dropwise, and heating is continued for 2 hours. After cooling, the oily layer is washed several times with water, taken up with benzol, washed again, and distilled at 148-150 C./4 mm. The product crystallizes on standing.
- Example 4 Mono-tertiary octyl chloro-resorcinol (diisobutyl chloro-resorcinol) may be prepared by the following procedure: Chloro-resorcinol prepared as in Example 1 from 27.5 gr. of resorcinol, is dissolved in 250 cc. glacial acetic acid. To this solution after cooling below 15 C. 25 cc. concentrated sulfuric acid are added 35 dropwise. Then 28 gr. diisobutylene are run in slowly. The mixture is then heated at 50 C. for
- Example 5 Tetiary amyl chloro-catechol may be prepared by the following procedure: 27.5 gr. catechol are dissolved in 75 cc. ether, and 37 45 gr. sulfuryl chloride added slowly. After heating 3 hours at 70 C. the solvent is evaporated, and to the residue 27 gr. tertiary amyl alcohol (dimethyl ethyl carbinol) are added, then 15 gr. anhydrous zinc chloride, and after the mixture 50 has dissolved, 5 cc. concentrated hydrochloric acid are added drop-wise, the temperature is raised to 125 C. and heating is continued for 2 hours. After cooling, the oily product is washed several times with water, then taken up with benzol, the 55 benzol extract washed, and then distilled, yielding a major fraction boiling at 135-140" C./3 mm.
- Example 6 Mono-tertiary octyl chloro-catechol (diisobutyl chloro-catechol) may be prepared as follows: Chloro-catechol prepared as in 5 from 27.5 gr. catechol is dissolved in 250 cc. glacial acetic acid, the solution cooled to 15 C., then 25 cc. concentrated sulfuric acid added dropwise, followed by 28 gr. diisobutylene. After warming the mixture at C. for 3 hours, it is poured into 1.5 liters water. The oily layer which separates is taken up with benzol, washed with water and distilled at 150-165" C./5 mm., the product solidifying on standing.
- tertiary octyl chloro-resorcinol can be obtained by starting with mono-tertiary octyl resorcinol (diisobutyl resorcinol prepared as per Niederl, journal American Chemical Society, June, 1933), dissolving it in ether, then adding sulfuryl chloride, heating about 3 hours at C., evaporating the solvent, washing the residue, and recrystallizing from carbon tetrachloride, thus obtaining a product as in Example 4.
- mono-tertiary octyl resorcinol diisobutyl resorcinol prepared as per Niederl, journal American Chemical Society, June, 1933
- sulfuryl chloride heating about 3 hours at C., evaporating the solvent, washing the residue, and recrystallizing from carbon tetrachloride, thus obtaining a product as in Example 4.
- Alkyl derivatives of chl'oro-dioxy benzols 10 having the general formula C6H2C1(OH)2CR1R2R3 where R1, R2, R3, are alkyls, either straightchained or branched, and the OH groups being either in ortho, in meta, or in para position to each other. 15
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Patented Dec. 3, 1935 :PATENT OFFICE ALKYL CHLORO-DIOXY-BENZOLS William E. Austin, New York, N. Y.
No Drawing. Application March 14, 1934 Serial No. 715,495
7 Claims.
This invention relates to new alkyl derivatives of chloro-dioxybenzols, characterized by the fact that the alkyl attached to the benzol nucleus is a tertiary alkyl group.
These compounds may be represented by the general formula C6H2C1(OH)2CR1R2R3 where R1, R2, R3 are alkyl groups, either straight-chained or branched, and the OH groups being either in ortho, in meta, or in para position to each other.
Among the alkyl chloro-dioxy benzols within the scope of this invention are the tertiary butyl, the tertiary amyl, the tertiary hexyl, the tertiary heptyl, the tertiary octyl, and the tertiary nonyl derivatives of chloro-pyrocatechol, of chlororesorcinol, and of chloro-hydroquinone, respectively.
The new alkyl chloro-dioxy benzols may be prepared by introducing the chlorine into the corresponding tertiary alkyl dioxy benzol, or by introducing the desired tertiary alkyl group into the chloro-dioXy benzol derivative.
The compounds of this invention possess especial germicidal and antiseptic activity coupled with relatively low toxicity, which properties may be utilized in the form of various antiseptics, germicidal and prophylactic solutions, jellies, lozenges and other media.
The following examples are illustrative of the preparation of the compounds of the present invention:
Example 1.Tertiary butyl chloro-resorcinol ((CH3)3C-C6H2C1(OH)2) may be prepared by the following process: 55 gr. of resorcinol are dissolved in 100 cc. ether, and '74 gr. sulfuryl chloride added dropwise. The temperature of the mixture is gradually raised to C. and maintained for 3 hours, during which time suction is applied to remove the HCl and S02 liberated in the reaction. The temperature is the-n raised to C. and the ether evaporated, leaving chloro-resorcinol. To this are added 50 gr. tertiary butyl alcohol (tri-methyl carbinol) while stirring and then 10 cc. concentrated hydrochloric acid, and in small portions 30 gr. of anhydrous zinc chloride, the mixture being heated about 1 hour at C. After cooling, the product is washed several times with water, dissolved in dilute caustic soda solution, reprecipitated with dilute hydrochloric acid, and the product then taken up with benzol, and again washed with water, after which the benzol solution is distilled, yielding a major fraction boiling at 140 C./5 mm. The product crystallizes on standing.
Example 2.Tertiary amyl chloro-resorcinol ((CH3)2C2H5CC6H2C1(OH)2) may be prepared by the following process: To chloro-resorcinol prepared as in Example 1 from 55 gr. resorcinol are added 50 gr. tertiary amyl alcohol (di-methyl ethyl carbinol) and 10 cc. concentrated hydro chloric acid and the mixture heated to 100 C. 5 Then 30 gr. anhydrous zinc chloride are gradually added, and heating is continued for 2 hours. After cooling, the product is washed with water, dissolved in dilute caustic soda, reprecipitated with dilute hydrochloric acid, then taken up with 10 benzol and again washed with water, after which the benzol solution is distilled. The major fraction is obtained at -150" C./7 mm. The product crystallizes on standing.
Example 3.-Tertiary amyl chloro-hydroquinone may be prepared by the following procedure: 28 gr. chloro-hydroquinone, 25 gr. tertiary amyl alcohol (dimethyl ethyl carbinol) and 12 gr. anhydrous zinc chloride are heated together with stirring to about 95 C. and when all is in solution 5 cc. concentrated hydrochloric acid are added dropwise, and heating is continued for 2 hours. After cooling, the oily layer is washed several times with water, taken up with benzol, washed again, and distilled at 148-150 C./4 mm. The product crystallizes on standing.
Example 4.--Mono-tertiary octyl chloro-resorcinol (diisobutyl chloro-resorcinol) may be prepared by the following procedure: Chloro-resorcinol prepared as in Example 1 from 27.5 gr. of resorcinol, is dissolved in 250 cc. glacial acetic acid. To this solution after cooling below 15 C. 25 cc. concentrated sulfuric acid are added 35 dropwise. Then 28 gr. diisobutylene are run in slowly. The mixture is then heated at 50 C. for
4 hours, and poured into 4 liters of water. The oil which separates is taken up with ether, washed and distilled, yielding an oil which solidifies. On 40 recrystallizing, a white granular product melting at l03-l04 C. is obtained.
Example 5.Tertiary amyl chloro-catechol may be prepared by the following procedure: 27.5 gr. catechol are dissolved in 75 cc. ether, and 37 45 gr. sulfuryl chloride added slowly. After heating 3 hours at 70 C. the solvent is evaporated, and to the residue 27 gr. tertiary amyl alcohol (dimethyl ethyl carbinol) are added, then 15 gr. anhydrous zinc chloride, and after the mixture 50 has dissolved, 5 cc. concentrated hydrochloric acid are added drop-wise, the temperature is raised to 125 C. and heating is continued for 2 hours. After cooling, the oily product is washed several times with water, then taken up with benzol, the 55 benzol extract washed, and then distilled, yielding a major fraction boiling at 135-140" C./3 mm.
Example 6.-Mono-tertiary octyl chloro-catechol (diisobutyl chloro-catechol) may be prepared as follows: Chloro-catechol prepared as in 5 from 27.5 gr. catechol is dissolved in 250 cc. glacial acetic acid, the solution cooled to 15 C., then 25 cc. concentrated sulfuric acid added dropwise, followed by 28 gr. diisobutylene. After warming the mixture at C. for 3 hours, it is poured into 1.5 liters water. The oily layer which separates is taken up with benzol, washed with water and distilled at 150-165" C./5 mm., the product solidifying on standing.
These compounds may be prepared also by chlorinating the corresponding tertiary alkyl dioxy-benzol, as for example, tertiary octyl chloro-resorcinol can be obtained by starting with mono-tertiary octyl resorcinol (diisobutyl resorcinol prepared as per Niederl, journal American Chemical Society, June, 1933), dissolving it in ether, then adding sulfuryl chloride, heating about 3 hours at C., evaporating the solvent, washing the residue, and recrystallizing from carbon tetrachloride, thus obtaining a product as in Example 4.
The invention is not limited by the descriptions or examples cited, which are merely illustrative.
I claim: 6
l. Alkyl derivatives of chloro-dioxy benzols having the general formula CsH2Cl(OH)2CR1R2R3 where R1, R2, R3 are alkyls, either straightchained or branched.
2. Alkyl derivatives of chl'oro-dioxy benzols 10 having the general formula C6H2C1(OH)2CR1R2R3 where R1, R2, R3, are alkyls, either straightchained or branched, and the OH groups being either in ortho, in meta, or in para position to each other. 15
3. Mono-tertiary alkyl chloro-resorcinols.
4. Mono-tertiary octyl chloro-resorcinols.
5. Mono-tertiary octyl chloro-resorcinol having the formula 6. Tertiary amyl chloro-resorcinol having the formula (CH3) 2C2H5C-C6H2C1 (OH) 2. 7. Tertiary butyl chl'oro-resorcinol.
WILLIAM E. AUSTIN. 25
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US715495A US2023160A (en) | 1934-03-14 | 1934-03-14 | Alkyl chloro-dioxy-benzols |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US715495A US2023160A (en) | 1934-03-14 | 1934-03-14 | Alkyl chloro-dioxy-benzols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US2023160A true US2023160A (en) | 1935-12-03 |
Family
ID=24874264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US715495A Expired - Lifetime US2023160A (en) | 1934-03-14 | 1934-03-14 | Alkyl chloro-dioxy-benzols |
Country Status (1)
| Country | Link |
|---|---|
| US (1) | US2023160A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2485562A (en) * | 1946-02-26 | 1949-10-25 | Koppers Co Inc | Production of 2,4,6-trichlororesorcin |
| US5410083A (en) * | 1993-10-15 | 1995-04-25 | The Dow Chemical Company | Synthesis of diaminoresorcinal from resorcinol |
-
1934
- 1934-03-14 US US715495A patent/US2023160A/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2485562A (en) * | 1946-02-26 | 1949-10-25 | Koppers Co Inc | Production of 2,4,6-trichlororesorcin |
| US5410083A (en) * | 1993-10-15 | 1995-04-25 | The Dow Chemical Company | Synthesis of diaminoresorcinal from resorcinol |
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