US20230096416A1 - Fluid handling device and fluid handling system - Google Patents
Fluid handling device and fluid handling system Download PDFInfo
- Publication number
- US20230096416A1 US20230096416A1 US17/490,091 US202117490091A US2023096416A1 US 20230096416 A1 US20230096416 A1 US 20230096416A1 US 202117490091 A US202117490091 A US 202117490091A US 2023096416 A1 US2023096416 A1 US 2023096416A1
- Authority
- US
- United States
- Prior art keywords
- protrusion
- fluid handling
- groove
- film
- arc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000012530 fluid Substances 0.000 title claims abstract description 68
- 239000012528 membrane Substances 0.000 claims abstract description 48
- 239000000758 substrate Substances 0.000 claims abstract description 35
- 239000000463 material Substances 0.000 description 9
- -1 polyethylene terephthalate Polymers 0.000 description 6
- 239000000806 elastomer Substances 0.000 description 5
- 238000005086 pumping Methods 0.000 description 5
- 150000001925 cycloalkenes Chemical class 0.000 description 4
- 229920005989 resin Polymers 0.000 description 4
- 239000011347 resin Substances 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004721 Polyphenylene oxide Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000002572 peristaltic effect Effects 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000570 polyether Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 229920002050 silicone resin Polymers 0.000 description 2
- 229920002379 silicone rubber Polymers 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920006285 olefinic elastomer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Images
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/1238—Machines, pumps, or pumping installations having flexible working members having peristaltic action using only one roller as the squeezing element, the roller moving on an arc of a circle during squeezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
- F04B43/00—Machines, pumps, or pumping installations having flexible working members
- F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
- F04B43/14—Machines, pumps, or pumping installations having flexible working members having peristaltic action having plate-like flexible members
Definitions
- the present invention relates to a fluid handling device and a fluid handling system.
- microchannel chip In recent years, a microchannel chip or the like has been used to analyze cells, proteins, and nucleic acids.
- the microchannel chip has the advantage of requiring only a small amount of reagents and samples for analysis, and are expected to be used in a variety of applications such as clinical tests, food tests and environment tests.
- a pump such as a peristaltic pump to the channel for flowing fluid to the channel.
- PTL 1 discloses a transfusion device which has a peristaltic pump (rotary membrane pump) including an arc-shaped pump channel.
- FIG. 1 A is a plan view schematically illustrating a rotary membrane pump 24 disclosed in PTL 1.
- Left view of FIG. 1 B is a sectional view taken along B 1 -B 1 line in FIG. 1 A .
- Right view of FIG. 1 B is a sectional view taken along B 2 -B 2 line in FIG. 1 A .
- As shown in the left view of FIG. 1 B there are spaces (grooves 23 closed by a film 22 ; pump channel) disposed symmetrically with respect to a center of an arc, in which fluid can flow.
- the right view of FIG. 1 B there is a space disposed one side with respect to the center of the arc, in which fluid can flow.
- a rotary membrane pump 24 is composed of a groove 23 disposed on a substrate 21 and a film 22 (diaphragm) disposed on the substrate 21 so as to close the groove 23 . Further, as can be seen from the right view of FIG. 1 B , the height of the area between both ends of the arc-shaped groove 23 is the same as the height of the surface of the substrate 21 , and the area is a protrusion 25 with respect to the groove 23 .
- pressing protrusions 11 of a rotary member 10 press the film 22 and the groove 23 is closed, and the rotary membrane pump 24 exerts a pumping function.
- two pressing protrusions 11 of the rotary member 10 press the film 22 to the bottom of the groove 23 and the rotary member 10 rotates to exert a pumping function.
- An object of the present invention is to provide a fluid handling device capable of preventing an inclination of the rotary member for pressing the rotary membrane pump. It is also an object of the present invention to provide a fluid handling system having this fluid handling device.
- a fluid handling device including: a substrate; an arc-shaped groove having a central angle more than 180° disposed on the substrate; a first protrusion located between both ends of the groove in the same circumference as the arc-shaped groove; a second protrusion disposed in the groove; and a film joined on the substrate so as to cover the groove, the first protrusion and the second protrusion, wherein the groove closed by the film functions as a rotary membrane pump.
- a fluid handling system includes the fluid handling device described above and a rotary member for pressing the rotary membrane pump of the fluid handling device.
- the present invention it is possible to provide a fluid handling device capable of preventing the inclination of the rotary member for pressing the rotary membrane pump. Further, according to the present invention, it is possible to provide a fluid handling system having the fluid handling device.
- FIG. 1 A is a plan view schematically illustrating a conventional rotary membrane pump
- FIG. 1 B is a cross-sectional view of a B 1 -B 1 line and a B 2 -B 2 line in FIG. 1 A
- FIG. 1 C is a cross-sectional view schematically illustrating operation of a fluid handling system including the conventional rotary membrane pump
- FIG. 2 A is a cross-sectional view of a fluid handling system according to an embodiment, and FIG. 2 B is a bottom view of a fluid handling device; 2
- FIG. 3 A is a partially enlarged sectional view of FIG. 2 A , and a cross-sectional view of an arc-shaped groove having a second protrusion
- FIG. 3 B is a cross-sectional view of an arcuate groove having no second protrusion
- FIG. 4 A is a plan view of a rotary member
- FIG. 4 B is a cross-sectional view of the rotary member
- FIG. 5 A is a diagram schematically illustrating the operation of a fluid handling system according to a comparative example
- FIG. 5 B is a diagram schematically illustrating the operation of the fluid handling system according to the embodiment.
- FIG. 2 A is a cross-sectional view illustrating a configuration of a fluid handling system 100 according to this embodiment.
- FIG. 2 B is a bottom view of a fluid handling device 200 of a fluid handling system 100 according to this embodiment.
- FIG. 3 A is a partially enlarged sectional view of the circumference of a rotary membrane pump 240 in FIG. 2 A (a groove 234 , a first protrusion 251 , a second protrusion 252 ).
- FIG. 3 B is a partially enlarged sectional view, when it is assumed that there is no second protrusion 252 in FIG. 3 A .
- FIG. 3 A is a cross-sectional view illustrating a configuration of a fluid handling system 100 according to this embodiment.
- FIG. 2 B is a bottom view of a fluid handling device 200 of a fluid handling system 100 according to this embodiment.
- FIG. 3 A is a partially enlarged sectional view of the circumference of a rotary membrane pump 240 in FIG. 2 A (a groove 2
- FIG. 2 A The cross-section of fluid handling system 100 in FIG. 2 A is a cross-sectional view of A-A line in FIG. 2 B .
- the fluid handling system 100 has a fluid handling device 200 , a first rotary member 110 for pressing a valve 232 of a rotary membrane valve of the fluid handling device 200 , and a second rotary member 120 for pressing the rotary membrane pump 240 of the fluid handling device 200 .
- the first rotary member 110 is rotated about the first central axis CA 1 by an external drive mechanism (not shown).
- the second rotary member 120 is rotated about a second central axis CA 2 by an external drive mechanism (not shown).
- the fluid handling device 200 has a substrate 210 and a film 220 and is installed so that the film 220 contacts with the first rotary member 110 and the second rotary member 120 . Note that, in FIG. 2 A , for clarity of the configuration of the fluid handling system 100 , each components are illustrated in condition of apart from each other.
- the fluid handling device 200 has a substrate 210 and a film 220 (see FIG. 2 A ).
- the groove 234 to from the flow path 233 an arc-shaped groove 241 to form an arc-shaped rotary membrane pump 240 , and through holes 231 to serve as an inlets or outlets are formed.
- the substrate 210 has a first protrusion 251 located between both ends of the arc-shaped groove 241 , and at least one second protrusion 252 disposed in the arc-shaped groove 241 .
- Film 220 is joined to one surface of the substrate 210 so as to cover the groove 234 , the first protrusion 251 , the second protrusion 252 and the through hole 231 formed on the substrate 210 .
- the groove 234 on the substrate 210 closed by the film 220 serves as a channel 233 for flowing a fluid such as a reagent or a liquid sample, a cleaning liquid, a gas, or a powder.
- the arc-shaped groove 241 closed by the film 220 becomes a rotary membrane pump 240 for moving the fluid.
- the film 220 which closes the arc-shaped groove 241 functions as a diaphragm of the rotary membrane pump 240 .
- the through hole 231 closed by the film 220 becomes a well 230 .
- the well 230 is used as an inlet for introducing the fluid, or an outlet for taking out the fluid.
- the thickness of the substrate 210 is not particularly limited.
- the thickness of the substrate 210 is 1 mm or more and 10 mm or less.
- the substrate 210 may be in the form of a film having a thickness of less than 1 mm.
- the material of the substrate 210 is not particularly limited.
- the material of the substrate 210 may be appropriately selected from known resins and glasses.
- the material of the substrate 210 may be an elastic body. Examples of materials of the substrate 210 include polyethylene terephthalate, polycarbonate, polymethyl methacrylate, polyvinyl chloride, polypropylene, polyether, polyethylene, polystyrene, cycloolefin-based resins, silicone resins and elastomers.
- the thickness of the film 220 is not particularly limited as long as it can function as a diaphragm.
- the thickness of the film 220 is 30 ⁇ m or more and 300 ⁇ m or less. In this embodiment, the thickness of the film 220 is 200 ⁇ m.
- the material of the film 220 is not particularly limited as long as it can function as a diaphragm.
- the material of the film 220 may be appropriately selected from known resins.
- Examples of materials of film 220 include polyethylene terephthalate, polycarbonate, polymethyl methacrylate, polyvinyl chloride, polypropylene, polyether, polyethylene, polystyrene, cycloolefin-based resins, silicone resins and elastomers.
- Examples of elastomers include olefinic elastomers and cycloolefin-based elastomers (cycloolefin-based elastomers).
- the film 220 is joined to the substrate 210 by, for example, thermal welding or laser welding, an adhesive or the like. Note that the material of the film 220 may be the same as or different from the material of the substrate 210 .
- the fluid handling device 200 has wells 230 , valves 232 , channels 233 , a rotary membrane pump 240 , and a vent hole 242 .
- the fluid introduced into the well 230 is sent to the channel 233 by driving the rotary membrane pump 240 while being controlled by the opening and closing of the valves 232 .
- these components will be described.
- the well 230 is a bottomed recess.
- the number of wells 230 is not particularly limited and is appropriately set depending on the intended use.
- the fluid handling device 200 has a plurality of wells 230 as shown in FIGS. 2 A and 2 B .
- each of the wells (recesses) 230 is composed of a through hole 231 formed in the substrate 210 and a film 220 which closes one opening of the through hole 231 .
- the shape and size of these recesses are not particularly limited, and appropriately set depending on the intended use.
- the shape of these recesses is, for example, a substantially cylindrical shape.
- the width of these recesses is, for example, about 2 mm.
- valves 232 control the flow of fluid in channel 233 .
- these valves 232 are rotary membrane valves (diaphragm valves) whose opening and closing are controlled by the rotation of the first rotary member 110 .
- a plurality of valves 232 is disposed on a circumference of a first circle centered on the first central axis CA 1 . Further, the valve 232 is disposed between the well 230 and the arc-shaped channel 233 (see FIG. 2 B ).
- the valve 232 is closed, when the first pressing protrusion 111 of the first rotary member 110 which rotates about the first central axis CA 1 presses the film 220 toward the bottom of the groove.
- the film 220 functions as a diaphragm for the valve 232 .
- the channel 233 is a flow path through which the fluid can move.
- One end of channel 233 is connected to a well 230 and the other end is connected to a rotary membrane pump 240
- each of the channels 233 is composed of a groove 234 formed in the substrate 210 , and a film 220 which closes the opening of the groove.
- the cross-sectional area and the cross-sectional shape of the channel is not particularly limited. Examples of cross-sectional shape of the channel include rectangular and U-shape.
- the rotary membrane pump 240 is composed of an arc-shaped groove 241 having a central angle a more than 180° disposed on the substrate and a film 220 disposed to cover the arc-shaped groove 241 , as shown in FIG. 2 B .
- the center angle a is not particularly limited as long as it exceeds 180°, the center angle a is preferably 270° or more, and more preferably 330° or more, in order to make the capacity of the rotary membrane pump 240 sufficient.
- the diaphragm of the rotary membrane pump 240 is a part of the flexible film 220 .
- the diaphragm has an arc-shape centered on the second central axis CA 2 .
- the cross-sectional area and the cross-sectional shape of the arc-shaped groove 241 is not particularly limited. Examples of cross-sectional shapes of the arc-shaped grooves 241 include rectangular and U-shape.
- the second protrusion 252 is disposed in the arc-shaped groove 241 .
- the second protrusion 252 may be at least one (one or more).
- the second protrusion 252 is a protrusion with respect to the bottom of the arc-shaped groove 241 .
- the second protrusion 252 is a concave portion with respect to the surface of the substrate 210 , but a convex portion with respect to the bottom of the arc-shaped groove 241 (see and compare with FIG. 3 B in which the arc-shaped groove 241 does not have a second protrusion 252 ).
- the second protrusion 252 is for preventing inclination of the second rotary member 120 by the first protrusion 251 (see FIG. 5 B ).
- the first protrusion 251 and the second protrusion 252 is preferably disposed so as to correspond to the arrangement of the plurality of the second pressing protrusion 122 in the second rotary member 120 . By being arranged so as to correspond in this way, the second rotary member 120 is prevented from being inclined.
- the number of the second protrusion 252 may be one or a plurality.
- the second pressing protrusions 122 are usually arranged at equal intervals around the rotational center of the second pressing protrusions (see FIG. 4 A , which will be described later). Therefore, the first protrusion and at least one second protrusion are preferably arranged at equal intervals on the circumference of the circle corresponding to the arc-shape.
- the number of the second pressing protrusion 122 may be a plurality. In this embodiment, the number of the second pressing convex portion 122 is two.
- the two second pressing protrusion 122 are disposed so as to face each other across the second central axis CA 2 of the second rotary member 120 (the center of the rotary membrane pump) (see FIG. 4 A which will be described later). Therefore, so as to correspond to this, the first protrusion 251 and the second protrusion 252 is disposed so as to face each other across the second central axis CA 2 (They are arranged at 180° intervals on the circumference about the second central axis).
- the first protrusion 251 and each of the two second protrusions 252 are arranged on the circumference around the second central axis CA 2 at 120° intervals, so as to correspond to the second pressing protrusions 122 .
- the first protrusion 251 and each of the three second protrusions 252 are arranged on the circumference around the second central axis CA 2 at 90° intervals, so as to correspond to the second pressing protrusions 122 .
- the length of the second protrusion 252 is substantially the same as the length of the first protrusion 251 , or longer than the length of the first protrusion 251 . From this, it is possible to avoid a state in which a certain second pressing protrusion 122 is riding on the first protrusion 251 and the other second pressing protrusion 122 is not riding on the second protrusion 252 . And as a result, the inclination of the second rotary member 120 is prevented.
- the length of the second protrusion 252 is, for example, 90% or more, 100% or more, or 110% or more of the length of the first protrusion 251 .
- the upper limit of the length of the second protrusion 252 is, for example, preferably 120% or less of the length of the first protrusion 251 in the direction along the circumference.
- the height of the second protrusion 252 from the bottom of the arc-shaped groove 241 is preferably equal to or less than the height of the first protrusion from the bottom of the arc-shaped groove 241 .
- the height of the second protrusion from the bottom of the arc-shaped groove 241 is preferably 50% to 100%, and more preferably 70% to 80% of the height of the first protrusion from the bottom of the arc-shaped groove 241 .
- the depth of the arc-shaped groove 241 is 200 ⁇ m
- the height of the first protrusion 251 from the bottom of the groove is 200 ⁇ m
- the height of the second protrusion 252 from the bottom of the groove is 150 ⁇ m. That is, in this embodiment, the height of the second protrusion 252 is 75% of the height of the first protrusion 251 .
- the height of the second protrusion 252 from the bottom of the arc-shaped groove 241 is the same as the height of the first protrusion 251 from the bottom of the arcuate groove 241 (in case the above numerical value is 100%)
- the height of the second protrusion 252 becomes the same height as the surface of the substrate 210 .
- the second protrusion 252 and the film 220 are not bonded for allowing the fluid passing between the second protrusion 252 and the film. As both of them are not joined together, the film 220 having flexibility is swollen, and fluid can pass.
- the vent hole 242 is a bottomed recess for discharging or introducing the fluid (e.g., air) in the rotary membrane pump, when the second protrusion 122 of the second rotary member 120 presses and slides on the diaphragm of the rotary membrane pump 240 .
- the vent hole 242 is composed of a through hole formed in the substrate 210 , and the film 220 which closes one of the openings of the through hole.
- the shape and size of the vent hole 242 is not particularly limited and can be appropriately set as necessary.
- the shape of the vent hole 242 for example, a substantially cylindrical shape.
- the width of the vent hole 242 is, for example, about 2 mm.
- FIG. 4 A is a plan view of the second rotary member 120
- FIG. 4 B is a cross-sectional view of a line B-B of FIG. 4 A .
- the second rotary member 120 includes a second body 121 , and a second pressing protrusion 122 for pressing the diaphragm.
- the second rotary member 120 rotates about the second central axis CA 2 to drive the rotary membrane pump 240 .
- the second body 121 has a cylindrical shape, and has the second pressing protrusion 122 disposed on its top surface.
- the second body 121 is rotatable about the second central axis CA 2 .
- the second body 121 is rotated by an external drive mechanism (not shown).
- the second pressing protrusion 122 is for pressing the diaphragm of the rotary membrane pump 240 (film 220 ).
- the second pressing protrusion 122 is preferably arranged at equal intervals on a circle around the second central axis CA 2 .
- the number of the second pressing protrusion 122 is not particularly limited as long as the number is a plurality.
- the number of the second pressing protrusion 122 is, for example, two, three, or four.
- the two second pressing protrusion 122 are arranged at intervals of 180° on a circle centered on the second central axis CA 2 .
- the second pressing protrusions 122 of the second rotary member 120 shown in FIGS. 4 A and 4 B press the diaphragm (film 220 ) of the rotary membrane pump, and rotate. When pressed, the film 220 flexes and contacts with the bottom of the arc-shaped groove 241 .
- the channel 233 becomes negative pressure, and the fluid in the channel 233 is moved toward the rotary membrane pump 240 .
- the second pressing protrusion 122 rotates toward the valve 232 (clockwise in 2 B) while pressing the diaphragm of the rotary membrane pump 240
- the channel 233 becomes positive pressure, and the fluid in the rotary membrane pump 240 is moved toward the channel 233 .
- FIG. 5 A schematically illustrate the operating conditions of the fluid handling system 100 of the comparative example having no second protrusion 252 .
- the left-hand view of FIG. 5 A is a plan view of a rotary membrane pump, and the right-hand view of FIG. 5 A is a cross-sectional view taken along line A-A in the left-hand view.
- FIG. 5 B schematically illustrate the state during operation of the rotary membrane pump 240 in the fluid handling device 200 according to the embodiment having the second protrusion 252 .
- the left view of the FIG. 5 B is a plan view of the rotary membrane pump
- the right view of FIG. 5 B is a cross-sectional view of the line A-A in the left view.
- FIGS. 5 A and B show that one of the second pressing protrusions 122 of the second rotary member 122 is on the first protrusion 251 between the ends of the rotary membrane pump 240 which is arc-shape.
- the rotary membrane pump 240 in contrast, as shown in FIG. 5 B , the rotary membrane pump 240 according to this embodiment, at the same time one of the second protrusions 122 rides on the first convex portion 251 , the other second pressing protrusion 122 rides on the second protrusion 252 .
- the second rotary member 120 is prevented from being inclined, and the other second pressing protrusion 122 can continue to properly press the film 220 toward the bottom of the groove 241 and completely close the groove 241 . This makes it easier for the pump function to be exerted properly.
- the rotary membrane pump 240 of the fluid handling device 200 has a second protrusion 252 in the arc-shaped groove 241 , and the second rotary member 120 is prevented from being inclined, and pumping function is exerted more appropriately.
- the fluid handling device and the fluid handling system of the present invention are useful in various applications such as, for example, clinical examination, food inspection, and environmental inspection.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Reciprocating Pumps (AREA)
Abstract
The present invention relates to a fluid handling device which can prevent an inclination of a rotary member. The fluid handling device includes a substrate; an arc-shaped groove having a central angle more than 180° disposed on the substrate; a first protrusion located between both ends of the groove in the same circumference as the arc-shaped groove; a second protrusion disposed in the groove; and a film joined on the substrate so as to cover the groove, the first protrusion and the second protrusion. The groove closed by the film functions as a rotary membrane pump.
Description
- The present invention relates to a fluid handling device and a fluid handling system.
- In recent years, a microchannel chip or the like has been used to analyze cells, proteins, and nucleic acids. The microchannel chip has the advantage of requiring only a small amount of reagents and samples for analysis, and are expected to be used in a variety of applications such as clinical tests, food tests and environment tests. In case the microchannel chip is used for analysis, it is necessary to connect a pump such as a peristaltic pump to the channel for flowing fluid to the channel.
- For example, PTL 1 discloses a transfusion device which has a peristaltic pump (rotary membrane pump) including an arc-shaped pump channel.
-
FIG. 1A is a plan view schematically illustrating arotary membrane pump 24 disclosed in PTL 1. Left view ofFIG. 1B is a sectional view taken along B1-B1 line inFIG. 1A . Right view ofFIG. 1B is a sectional view taken along B2-B2 line inFIG. 1A . As shown in the left view ofFIG. 1B , there are spaces (grooves 23 closed by afilm 22; pump channel) disposed symmetrically with respect to a center of an arc, in which fluid can flow. On the other hand, as shown in the right view ofFIG. 1B , there is a space disposed one side with respect to the center of the arc, in which fluid can flow. - As shown in
FIG. 1B , arotary membrane pump 24 is composed of agroove 23 disposed on asubstrate 21 and a film 22 (diaphragm) disposed on thesubstrate 21 so as to close thegroove 23. Further, as can be seen from the right view ofFIG. 1B , the height of the area between both ends of the arc-shaped groove 23 is the same as the height of the surface of thesubstrate 21, and the area is aprotrusion 25 with respect to thegroove 23. - As shown in
FIG. 1C , pressingprotrusions 11 of arotary member 10 press thefilm 22 and thegroove 23 is closed, and therotary membrane pump 24 exerts a pumping function. - Specifically, as shown in
FIG. 1C , two pressingprotrusions 11 of therotary member 10 press thefilm 22 to the bottom of thegroove 23 and therotary member 10 rotates to exert a pumping function. - Here, as shown in the left view of
FIG. 1C , when both of the twopressing protrusions 11 are on thegroove 23 and move while pressing thefilm 22 to the bottom of thegrooves 23, therotary member 10 rotates without problems, and the pumping function is appropriately exhibited. - However, as shown in the right view of
FIG. 1C , when one of thepressing protrusions 11 is on theprotrusion 25 between the ends of the arc-shaped groove 23, thepressing protrusion 11 rides on theprotrusion 25, and therotary member 10 may be inclined. Thus, the otherpressing protrusion 11 cannot properly press thefilm 22 to the bottom of thegroove 23. Consequently, therotary membrane pump 24 may not be able to exert an appropriate pumping function. - An object of the present invention is to provide a fluid handling device capable of preventing an inclination of the rotary member for pressing the rotary membrane pump. It is also an object of the present invention to provide a fluid handling system having this fluid handling device.
- A fluid handling device according to an embodiment of the present invention including: a substrate; an arc-shaped groove having a central angle more than 180° disposed on the substrate; a first protrusion located between both ends of the groove in the same circumference as the arc-shaped groove; a second protrusion disposed in the groove; and a film joined on the substrate so as to cover the groove, the first protrusion and the second protrusion, wherein the groove closed by the film functions as a rotary membrane pump.
- A fluid handling system according to an embodiment of the present invention includes the fluid handling device described above and a rotary member for pressing the rotary membrane pump of the fluid handling device.
- According to the present invention, it is possible to provide a fluid handling device capable of preventing the inclination of the rotary member for pressing the rotary membrane pump. Further, according to the present invention, it is possible to provide a fluid handling system having the fluid handling device.
-
FIG. 1A is a plan view schematically illustrating a conventional rotary membrane pump, andFIG. 1B is a cross-sectional view of a B1-B1 line and a B2-B2 line inFIG. 1A , andFIG. 1C is a cross-sectional view schematically illustrating operation of a fluid handling system including the conventional rotary membrane pump; 1 -
FIG. 2A is a cross-sectional view of a fluid handling system according to an embodiment, andFIG. 2B is a bottom view of a fluid handling device; 2 -
FIG. 3A is a partially enlarged sectional view ofFIG. 2A , and a cross-sectional view of an arc-shaped groove having a second protrusion, andFIG. 3B is a cross-sectional view of an arcuate groove having no second protrusion; 3 -
FIG. 4A is a plan view of a rotary member, andFIG. 4B is a cross-sectional view of the rotary member; and -
FIG. 5A is a diagram schematically illustrating the operation of a fluid handling system according to a comparative example, andFIG. 5B is a diagram schematically illustrating the operation of the fluid handling system according to the embodiment. - Hereinafter, an embodiment of the present invention will be described in detail with reference to the drawings.
-
FIG. 2A is a cross-sectional view illustrating a configuration of afluid handling system 100 according to this embodiment.FIG. 2B is a bottom view of afluid handling device 200 of afluid handling system 100 according to this embodiment.FIG. 3A is a partially enlarged sectional view of the circumference of arotary membrane pump 240 inFIG. 2A (agroove 234, afirst protrusion 251, a second protrusion 252).FIG. 3B is a partially enlarged sectional view, when it is assumed that there is nosecond protrusion 252 inFIG. 3A . InFIG. 2B , thegroove 234 which serves as achannel 233 and other components are illustrated for explanation, although they are not seen originally since they are covered by thefilm 220. The cross-section offluid handling system 100 inFIG. 2A is a cross-sectional view of A-A line inFIG. 2B . - As shown in
FIG. 2A , thefluid handling system 100 has afluid handling device 200, a firstrotary member 110 for pressing avalve 232 of a rotary membrane valve of thefluid handling device 200, and a secondrotary member 120 for pressing therotary membrane pump 240 of thefluid handling device 200. - The first
rotary member 110 is rotated about the first central axis CA1 by an external drive mechanism (not shown). The secondrotary member 120 is rotated about a second central axis CA2 by an external drive mechanism (not shown). Thefluid handling device 200 has asubstrate 210 and afilm 220 and is installed so that thefilm 220 contacts with the firstrotary member 110 and the secondrotary member 120. Note that, inFIG. 2A , for clarity of the configuration of thefluid handling system 100, each components are illustrated in condition of apart from each other. - As mentioned above, the
fluid handling device 200 has asubstrate 210 and a film 220 (seeFIG. 2A ). In thesubstrate 210, thegroove 234 to from theflow path 233, an arc-shapedgroove 241 to form an arc-shapedrotary membrane pump 240, and throughholes 231 to serve as an inlets or outlets are formed. Further, thesubstrate 210 has afirst protrusion 251 located between both ends of the arc-shapedgroove 241, and at least onesecond protrusion 252 disposed in the arc-shapedgroove 241. -
Film 220 is joined to one surface of thesubstrate 210 so as to cover thegroove 234, thefirst protrusion 251, thesecond protrusion 252 and the throughhole 231 formed on thesubstrate 210. Thegroove 234 on thesubstrate 210 closed by thefilm 220 serves as achannel 233 for flowing a fluid such as a reagent or a liquid sample, a cleaning liquid, a gas, or a powder. The arc-shapedgroove 241 closed by thefilm 220 becomes arotary membrane pump 240 for moving the fluid. Incidentally, thefilm 220 which closes the arc-shapedgroove 241 functions as a diaphragm of therotary membrane pump 240. Further, the throughhole 231 closed by thefilm 220 becomes a well 230. Incidentally, the well 230 is used as an inlet for introducing the fluid, or an outlet for taking out the fluid. - The thickness of the
substrate 210 is not particularly limited. For example, the thickness of thesubstrate 210 is 1 mm or more and 10 mm or less. Thesubstrate 210 may be in the form of a film having a thickness of less than 1 mm. Also, the material of thesubstrate 210 is not particularly limited. For example, the material of thesubstrate 210 may be appropriately selected from known resins and glasses. The material of thesubstrate 210 may be an elastic body. Examples of materials of thesubstrate 210 include polyethylene terephthalate, polycarbonate, polymethyl methacrylate, polyvinyl chloride, polypropylene, polyether, polyethylene, polystyrene, cycloolefin-based resins, silicone resins and elastomers. - The thickness of the
film 220 is not particularly limited as long as it can function as a diaphragm. For example, the thickness of thefilm 220 is 30 μm or more and 300 μm or less. In this embodiment, the thickness of thefilm 220 is 200 μm. Also, the material of thefilm 220 is not particularly limited as long as it can function as a diaphragm. For example, the material of thefilm 220 may be appropriately selected from known resins. - Examples of materials of
film 220 include polyethylene terephthalate, polycarbonate, polymethyl methacrylate, polyvinyl chloride, polypropylene, polyether, polyethylene, polystyrene, cycloolefin-based resins, silicone resins and elastomers. Examples of elastomers include olefinic elastomers and cycloolefin-based elastomers (cycloolefin-based elastomers). Thefilm 220 is joined to thesubstrate 210 by, for example, thermal welding or laser welding, an adhesive or the like. Note that the material of thefilm 220 may be the same as or different from the material of thesubstrate 210. - As shown in
FIGS. 2A and 2B , thefluid handling device 200 haswells 230,valves 232,channels 233, arotary membrane pump 240, and avent hole 242. The fluid introduced into the well 230 is sent to thechannel 233 by driving therotary membrane pump 240 while being controlled by the opening and closing of thevalves 232. Hereinafter, these components will be described. - The well 230 is a bottomed recess. The number of
wells 230 is not particularly limited and is appropriately set depending on the intended use. In this embodiment, thefluid handling device 200 has a plurality ofwells 230 as shown inFIGS. 2A and 2B . - In this embodiment, each of the wells (recesses) 230 is composed of a through
hole 231 formed in thesubstrate 210 and afilm 220 which closes one opening of the throughhole 231. The shape and size of these recesses are not particularly limited, and appropriately set depending on the intended use. The shape of these recesses is, for example, a substantially cylindrical shape. The width of these recesses is, for example, about 2 mm. - The
valves 232 control the flow of fluid inchannel 233. In this embodiment, thesevalves 232 are rotary membrane valves (diaphragm valves) whose opening and closing are controlled by the rotation of the firstrotary member 110. In this embodiment, a plurality ofvalves 232 is disposed on a circumference of a first circle centered on the first central axis CA1. Further, thevalve 232 is disposed between the well 230 and the arc-shaped channel 233 (seeFIG. 2B ). - The
valve 232 is closed, when the firstpressing protrusion 111 of the firstrotary member 110 which rotates about the first central axis CA1 presses thefilm 220 toward the bottom of the groove. Thus, thefilm 220 functions as a diaphragm for thevalve 232. - The
channel 233 is a flow path through which the fluid can move. One end ofchannel 233 is connected to a well 230 and the other end is connected to arotary membrane pump 240 - In this embodiment, each of the
channels 233 is composed of agroove 234 formed in thesubstrate 210, and afilm 220 which closes the opening of the groove. The cross-sectional area and the cross-sectional shape of the channel is not particularly limited. Examples of cross-sectional shape of the channel include rectangular and U-shape. - The
rotary membrane pump 240 is composed of an arc-shapedgroove 241 having a central angle a more than 180° disposed on the substrate and afilm 220 disposed to cover the arc-shapedgroove 241, as shown inFIG. 2B . Although the center angle a is not particularly limited as long as it exceeds 180°, the center angle a is preferably 270° or more, and more preferably 330° or more, in order to make the capacity of therotary membrane pump 240 sufficient. - One end of the
rotary membrane pump 240 is connected to thechannel 233, and the other end of therotary membrane pump 240 is connected to thevent hole 242 via thechannel 233. The diaphragm of therotary membrane pump 240 is a part of theflexible film 220. The diaphragm has an arc-shape centered on the second central axis CA2. The cross-sectional area and the cross-sectional shape of the arc-shapedgroove 241 is not particularly limited. Examples of cross-sectional shapes of the arc-shapedgrooves 241 include rectangular and U-shape. - As shown in
FIG. 2B , there is thefirst protrusion 251 between both ends of the arc-shapedgroove 241. The secondpressing protrusion 122 passes on thefirst protrusion 251, while pressing thefirst protrusion 251. Therefore, the secondrotary member 120 is easily subjected to a force such as tilting, if there is not thesecond protrusion 252 described later (seeFIG. 5A ). - As shown in
FIG. 2B andFIG. 3A , thesecond protrusion 252 is disposed in the arc-shapedgroove 241. Thesecond protrusion 252 may be at least one (one or more). Thesecond protrusion 252 is a protrusion with respect to the bottom of the arc-shapedgroove 241. For example, inFIG. 3A , thesecond protrusion 252 is a concave portion with respect to the surface of thesubstrate 210, but a convex portion with respect to the bottom of the arc-shaped groove 241 (see and compare withFIG. 3B in which the arc-shapedgroove 241 does not have a second protrusion 252). - The
second protrusion 252 is for preventing inclination of the secondrotary member 120 by the first protrusion 251 (seeFIG. 5B ). - The
first protrusion 251 and thesecond protrusion 252 is preferably disposed so as to correspond to the arrangement of the plurality of the secondpressing protrusion 122 in the secondrotary member 120. By being arranged so as to correspond in this way, the secondrotary member 120 is prevented from being inclined. The number of thesecond protrusion 252 may be one or a plurality. - For example, in plan view of the second
rotary member 120, the secondpressing protrusions 122 are usually arranged at equal intervals around the rotational center of the second pressing protrusions (seeFIG. 4A , which will be described later). Therefore, the first protrusion and at least one second protrusion are preferably arranged at equal intervals on the circumference of the circle corresponding to the arc-shape. - The number of the second
pressing protrusion 122 may be a plurality. In this embodiment, the number of the second pressingconvex portion 122 is two. The two secondpressing protrusion 122 are disposed so as to face each other across the second central axis CA2 of the second rotary member 120 (the center of the rotary membrane pump) (seeFIG. 4A which will be described later). Therefore, so as to correspond to this, thefirst protrusion 251 and thesecond protrusion 252 is disposed so as to face each other across the second central axis CA2 (They are arranged at 180° intervals on the circumference about the second central axis). - Similarly, when the number of the second
pressing protrusion 122 is three and they are arranged evenly (at 120° intervals), thefirst protrusion 251 and each of the twosecond protrusions 252 are arranged on the circumference around the second central axis CA2 at 120° intervals, so as to correspond to the secondpressing protrusions 122. - Similarly, when the number of the second
pressing protrusion 122 is four and they are arranged evenly (at 90° intervals), thefirst protrusion 251 and each of the threesecond protrusions 252 are arranged on the circumference around the second central axis CA2 at 90° intervals, so as to correspond to the secondpressing protrusions 122. - In the direction along the circumference, it is preferable that the length of the
second protrusion 252 is substantially the same as the length of thefirst protrusion 251, or longer than the length of thefirst protrusion 251. From this, it is possible to avoid a state in which a certain secondpressing protrusion 122 is riding on thefirst protrusion 251 and the other secondpressing protrusion 122 is not riding on thesecond protrusion 252. And as a result, the inclination of the secondrotary member 120 is prevented. - Specifically, in the direction along the circumference, the length of the
second protrusion 252 is, for example, 90% or more, 100% or more, or 110% or more of the length of thefirst protrusion 251. The upper limit of the length of thesecond protrusion 252 is, for example, preferably 120% or less of the length of thefirst protrusion 251 in the direction along the circumference. When the length of thesecond protrusion 252 is within the above range with respect to the length of thefirst protrusion 251, the inclination of the secondrotary member 120 is prevented. - The height of the
second protrusion 252 from the bottom of the arc-shapedgroove 241 is preferably equal to or less than the height of the first protrusion from the bottom of the arc-shapedgroove 241. Specifically, the height of the second protrusion from the bottom of the arc-shapedgroove 241 is preferably 50% to 100%, and more preferably 70% to 80% of the height of the first protrusion from the bottom of the arc-shapedgroove 241. - In the present embodiment, the depth of the arc-shaped
groove 241 is 200 μm, the height of thefirst protrusion 251 from the bottom of the groove is 200 μm, and the height of thesecond protrusion 252 from the bottom of the groove is 150 μm. That is, in this embodiment, the height of thesecond protrusion 252 is 75% of the height of thefirst protrusion 251. - Incidentally, in case the height of the
second protrusion 252 from the bottom of the arc-shapedgroove 241 is the same as the height of thefirst protrusion 251 from the bottom of the arcuate groove 241 (in case the above numerical value is 100%), the height of thesecond protrusion 252 becomes the same height as the surface of thesubstrate 210. Thus, there is no space between thesecond protrusion 252 and thefilm 220 disposed thereon. In this case, it is necessary that thesecond protrusion 252 and thefilm 220 are not bonded for allowing the fluid passing between thesecond protrusion 252 and the film. As both of them are not joined together, thefilm 220 having flexibility is swollen, and fluid can pass. - The
vent hole 242 is a bottomed recess for discharging or introducing the fluid (e.g., air) in the rotary membrane pump, when thesecond protrusion 122 of the secondrotary member 120 presses and slides on the diaphragm of therotary membrane pump 240. In this embodiment, thevent hole 242 is composed of a through hole formed in thesubstrate 210, and thefilm 220 which closes one of the openings of the through hole. The shape and size of thevent hole 242 is not particularly limited and can be appropriately set as necessary. The shape of thevent hole 242, for example, a substantially cylindrical shape. The width of thevent hole 242 is, for example, about 2 mm. -
FIG. 4A is a plan view of the secondrotary member 120, andFIG. 4B is a cross-sectional view of a line B-B ofFIG. 4A . - The second
rotary member 120 includes asecond body 121, and a secondpressing protrusion 122 for pressing the diaphragm. The secondrotary member 120 rotates about the second central axis CA2 to drive therotary membrane pump 240. - The
second body 121 has a cylindrical shape, and has the secondpressing protrusion 122 disposed on its top surface. Thesecond body 121 is rotatable about the second central axis CA2. Thesecond body 121 is rotated by an external drive mechanism (not shown). - The second
pressing protrusion 122 is for pressing the diaphragm of the rotary membrane pump 240 (film 220). The secondpressing protrusion 122 is preferably arranged at equal intervals on a circle around the second central axis CA2. The number of the secondpressing protrusion 122 is not particularly limited as long as the number is a plurality. The number of the secondpressing protrusion 122 is, for example, two, three, or four. - In this embodiment, as shown in
FIGS. 4A and 4B , the two secondpressing protrusion 122 are arranged at intervals of 180° on a circle centered on the second central axis CA2. - Next, it will be described below that the rotary membrane pump is driven by the second
rotary member 120. - The second
pressing protrusions 122 of the secondrotary member 120 shown inFIGS. 4A and 4B press the diaphragm (film 220) of the rotary membrane pump, and rotate. When pressed, thefilm 220 flexes and contacts with the bottom of the arc-shapedgroove 241. - For example, when the second
pressing protrusion 122 rotates toward the vent hole 242 (counterclockwise in 2B) while pressing the diaphragm of therotary membrane pump 240, thechannel 233 becomes negative pressure, and the fluid in thechannel 233 is moved toward therotary membrane pump 240. On the other hand, when the secondpressing protrusion 122 rotates toward the valve 232 (clockwise in 2B) while pressing the diaphragm of therotary membrane pump 240, thechannel 233 becomes positive pressure, and the fluid in therotary membrane pump 240 is moved toward thechannel 233. - Next, the operation of the fluid handling system will be described with reference to
FIGS. 5A and 5B . - The left-hand and right-hand views of
FIG. 5A schematically illustrate the operating conditions of thefluid handling system 100 of the comparative example having nosecond protrusion 252. The left-hand view ofFIG. 5A is a plan view of a rotary membrane pump, and the right-hand view ofFIG. 5A is a cross-sectional view taken along line A-A in the left-hand view. - On the other hand, the left-hand view and the right-hand view of
FIG. 5B schematically illustrate the state during operation of therotary membrane pump 240 in thefluid handling device 200 according to the embodiment having thesecond protrusion 252. The left view of theFIG. 5B is a plan view of the rotary membrane pump, the right view ofFIG. 5B is a cross-sectional view of the line A-A in the left view. - Incidentally,
FIGS. 5A and B show that one of the secondpressing protrusions 122 of the secondrotary member 122 is on thefirst protrusion 251 between the ends of therotary membrane pump 240 which is arc-shape. - As shown in
FIG. 5A , in the conventional rotary membrane pump, when one of the secondpressing protrusions 122 is moved on thefirst protrusion 251, the second pressing protrusion rides on thefirst protrusion 251. Thus, the secondrotary member 120 is inclined. Then, the inclination of the secondrotary member 120 causes that the other secondpressing protrusion 122 cannot appropriately press thefilm 220 toward the bottom of thegroove 241 and completely close thegroove 241. This may cause the pump to fail to function properly. - In contrast, as shown in
FIG. 5B , therotary membrane pump 240 according to this embodiment, at the same time one of thesecond protrusions 122 rides on the firstconvex portion 251, the other secondpressing protrusion 122 rides on thesecond protrusion 252. Thus, the secondrotary member 120 is prevented from being inclined, and the other secondpressing protrusion 122 can continue to properly press thefilm 220 toward the bottom of thegroove 241 and completely close thegroove 241. This makes it easier for the pump function to be exerted properly. - According to the
fluid handling system 100 of the present embodiment, therotary membrane pump 240 of thefluid handling device 200 has asecond protrusion 252 in the arc-shapedgroove 241, and the secondrotary member 120 is prevented from being inclined, and pumping function is exerted more appropriately. - The fluid handling device and the fluid handling system of the present invention are useful in various applications such as, for example, clinical examination, food inspection, and environmental inspection.
-
- 10 Rotary member
- 11 Pressing protrusion
- 21, 210 Substrate
- 22, 220 Film
- 23 Groove
- 24, 240 Rotary membrane pump
- 25 Protrusion
- 100 Fluid handling system
- 110 First rotary member
- 111 First pressing protrusion
- 120 Second rotary member
- 121 Second body
- 122 Second pressing protrusion
- 200 Fluid handling device
- 230 Well
- 231 Through hole
- 232 Valve
- 233 Channel
- 234 Groove
- 241 Arc-shaped groove
- 242 Vent hole
- 251 First protrusion
- 252 Second protrusion
- CA1 First central axis
- CA2 Second central axis
Claims (6)
1. A fluid handling device comprising:
a substrate;
an arc-shaped groove having a central angle more than 180° disposed on the substrate;
a first protrusion located between both ends of the groove in the same circumference as the arc-shaped groove;
a second protrusion disposed in the groove; and
a film joined on the substrate so as to cover the groove, the first protrusion and the second protrusion,
wherein the groove closed by the film functions as a rotary membrane pump.
2. The fluid handling device according to claim 1 , wherein, in the direction of the circumference, the length of the first protrusion is substantially the same as the length of the second protrusion.
3. The fluid handling device according to claim 1 , wherein the height of the second protrusion from the bottom of the groove is equal to or less than the height of the first protrusion from the bottom of the groove.
4. The fluid handling device according to claim 3 , wherein the height of the second protrusion from the bottom of the groove is less than the height of the first protrusion from the bottom of the groove.
5. The fluid handling device according to claim 1 , wherein, the first protrusion and the second protrusion are arranged at equal intervals on the circumference
6. A fluid handling system comprising:
the fluid handling device according to claim 1 ; and
a rotary member for pressing the rotary membrane pump of the fluid handling device.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17/490,091 US20230096416A1 (en) | 2021-09-30 | 2021-09-30 | Fluid handling device and fluid handling system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17/490,091 US20230096416A1 (en) | 2021-09-30 | 2021-09-30 | Fluid handling device and fluid handling system |
Publications (1)
Publication Number | Publication Date |
---|---|
US20230096416A1 true US20230096416A1 (en) | 2023-03-30 |
Family
ID=85706602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US17/490,091 Abandoned US20230096416A1 (en) | 2021-09-30 | 2021-09-30 | Fluid handling device and fluid handling system |
Country Status (1)
Country | Link |
---|---|
US (1) | US20230096416A1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140105766A1 (en) * | 2011-06-17 | 2014-04-17 | Siemens Healthcare Diagnostics Inc. | Face drive fluid pump |
US8784079B2 (en) * | 2010-10-13 | 2014-07-22 | Fresenius Kabi Deutschland Gmbh | Pump module, pump base module and pump system |
US9987630B2 (en) * | 2014-07-09 | 2018-06-05 | Enplas Corporation | Fluid handling device and method of using the same |
US20210100938A1 (en) * | 2019-10-08 | 2021-04-08 | Alcon Inc. | Peristaltic pumps with reduced pulsations |
-
2021
- 2021-09-30 US US17/490,091 patent/US20230096416A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8784079B2 (en) * | 2010-10-13 | 2014-07-22 | Fresenius Kabi Deutschland Gmbh | Pump module, pump base module and pump system |
US20140105766A1 (en) * | 2011-06-17 | 2014-04-17 | Siemens Healthcare Diagnostics Inc. | Face drive fluid pump |
US9987630B2 (en) * | 2014-07-09 | 2018-06-05 | Enplas Corporation | Fluid handling device and method of using the same |
US20210100938A1 (en) * | 2019-10-08 | 2021-04-08 | Alcon Inc. | Peristaltic pumps with reduced pulsations |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6981762B2 (en) | Fluid handling device and fluid handling method | |
WO2018030253A1 (en) | Fluid handling device, fluid handling method, and flow path chip | |
US20230096416A1 (en) | Fluid handling device and fluid handling system | |
US12011717B2 (en) | Fluid handling device and fluid handling system | |
US20230097798A1 (en) | Fluid handling device and fluid handling system | |
US11592114B2 (en) | Fluid handling device and fluid handling system | |
US11712695B2 (en) | Fluid handling device and fluid handling system | |
US11623217B2 (en) | Liquid handling device and liquid handling method | |
US20220371004A1 (en) | Fluid handling device and fluid handling system including the same | |
US20210283602A1 (en) | Liquid handling device and liquid handling method | |
US20240093683A1 (en) | Fluid handling system | |
CN111742225B (en) | Fluid treatment device | |
US20240082837A1 (en) | Handling device and fluid handling system | |
US20230095969A1 (en) | Liquid handling device and liquid handling system | |
WO2022157987A1 (en) | Liquid handling system | |
US20230158486A1 (en) | Fluid handling device and fluid handling system | |
US20230094429A1 (en) | Cartridge and liquid handling device | |
CN111902663A (en) | Fluid processing device and fluid processing system | |
US20230128269A1 (en) | Fluid handling device and fluid handling system including the same | |
JP2023096871A (en) | Cartridge, liquid handling device and use method for liquid handling device | |
WO2020012876A1 (en) | Fluid-handling device and fluid-handling system | |
JP2020116568A (en) | Fluid treatment apparatus, fluid treatment system, and transfer base plate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: ENPLAS CORPORATION, JAPAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SUZUKI, SEIICHIRO;SUNAGA, NOBUYA;SIGNING DATES FROM 20210917 TO 20210922;REEL/FRAME:058411/0927 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |