US20230033130A1 - Closed-loop artificial pancreas controlled by body movements - Google Patents

Closed-loop artificial pancreas controlled by body movements Download PDF

Info

Publication number
US20230033130A1
US20230033130A1 US17/791,222 US202017791222A US2023033130A1 US 20230033130 A1 US20230033130 A1 US 20230033130A1 US 202017791222 A US202017791222 A US 202017791222A US 2023033130 A1 US2023033130 A1 US 2023033130A1
Authority
US
United States
Prior art keywords
module
control module
sub
infusion
body movements
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
US17/791,222
Inventor
Cuijun YANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtrum Technologies Inc
Original Assignee
Medtrum Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtrum Technologies Inc filed Critical Medtrum Technologies Inc
Assigned to MEDTRUM TECHNOLOGIES INC. reassignment MEDTRUM TECHNOLOGIES INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: YANG, Cuijun
Publication of US20230033130A1 publication Critical patent/US20230033130A1/en
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/746—Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L9/00—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols
    • H04L9/32—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system or for message authentication, e.g. authorization, entity authentication, data integrity or data verification, non-repudiation, key authentication or verification of credentials
    • H04L9/3226—Cryptographic mechanisms or cryptographic arrangements for secret or secure communications; Network security protocols including means for verifying the identity or authority of a user of the system or for message authentication, e.g. authorization, entity authentication, data integrity or data verification, non-repudiation, key authentication or verification of credentials using a predetermined code, e.g. password, passphrase or PIN
    • H04L9/3231—Biological data, e.g. fingerprint, voice or retina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0219—Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
    • A61M2005/1726—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure the body parameters being measured at, or proximate to, the infusion site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/10—General characteristics of the apparatus with powered movement mechanisms
    • A61M2205/103—General characteristics of the apparatus with powered movement mechanisms rotating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/18—General characteristics of the apparatus with alarm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/27—General characteristics of the apparatus preventing use
    • A61M2205/276—General characteristics of the apparatus preventing use preventing unwanted use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3334—Measuring or controlling the flow rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/35—Communication
    • A61M2205/3576—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver
    • A61M2205/3584—Communication with non implanted data transmission devices, e.g. using external transmitter or receiver using modem, internet or bluetooth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2209/00—Ancillary equipment
    • A61M2209/01—Remote controllers for specific apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/005—Parameter used as control input for the apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/20—Blood composition characteristics
    • A61M2230/201—Glucose concentration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/62—Posture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2230/00—Measuring parameters of the user
    • A61M2230/63—Motion, e.g. physical activity
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L2209/00—Additional information or applications relating to cryptographic mechanisms or cryptographic arrangements for secret or secure communication H04L9/00
    • H04L2209/88—Medical equipments

Definitions

  • the present invention mainly relates to the field of medical instruments, in particular to a closed-loop artificial pancreas controlled by body movements.
  • pancreas in a normal person can automatically monitor the amount of glucose in the blood and automatically secrete the required dosage of insulin/glucagon.
  • the function of the pancreas is abnormal, and the pancreas cannot normally secrete required dosage of insulin. Therefore, diabetes is a metabolic disease caused by abnormal pancreatic function and also a lifelong disease.
  • medical technology cannot cure diabetes, but can only control the onset and development of diabetes and its complications by stabilizing blood glucose.
  • CGM Continuous Glucose Monitoring
  • BG blood glucose
  • the infusion device as a closed-loop or semi-closed-loop artificial pancreas, injects the currently required insulin dose.
  • the embodiment of the present invention discloses a closed-loop artificial pancreas controlled by body movements. If the user's body movement, as a functional instruction, is sensed by a sensing module, the control module can control the sensor or the infusion module to execute the corresponding function without the user manually inputting the functional instruction on the remote device, enhancing the user experience.
  • the invention discloses a closed-loop artificial pancreas controlled by body movements, which comprises: a sensor used for detecting blood glucose concentration; an infusion module used for infusing drug into the body; a control module connected to the sensor and the infusion module, respectively; and a sensing module operatively connected to the control module and used to sense or recognize the user's body movements, and different body movements represent different functional instructions, and according to the body movement sensed or recognized by the sensing module, the control module controls the sensor or the infusion module to execute corresponding functional instructions.
  • functional instructions include calibrating the sensor, activating or deactivating the sensor, adjusting the blood glucose concentration alarm threshold, infusing drug or stopping infusing drug, priming the infusion needle, puncturing or retracting the infusion needle, adjusting the infusion speed or infusion mode, adjusting the amount of drug infusion, turning on or off the alarm, connecting or disconnecting the remote device, switching the user's physical state, or starting the event.
  • the drug includes insulin or glucagon.
  • control module includes a first sub-control module connected to the sensor and a second sub-control module connected to the infusion module, and the first sub-control module and the second sub-control module are wirelessly connected, and the sensing module is connected to the first sub-control module or the second sub-control module.
  • the senor and the infusion module are pasted on different positions of the user's skin
  • the first sub-control module is a transmitter while the second sub-control module is a pump base.
  • the sensing module includes a first sub-sensing module connected to the first sub-control module and a second sub-sensing module connected to the second sub-control module.
  • it further includes a body movement verification module which is connected to the sensing module.
  • the body movements include one or a combination of jumping, squatting, leg movements, arm movements, taps on the sensing module, bending over, torso twist, special way of walking.
  • a linear acceleration sensor or a gyroscope sensor is provided in the sensing module.
  • the linear acceleration sensor is a three-axis linear acceleration sensor.
  • the sensing module, the control module, the sensor and the infusion module are arranged in a single device.
  • a control module connected to the sensor and the infusion module, respectively; and a sensing module operatively connected to the control module and used to sense or recognize the user's body movements, and different body movements represent different functional instructions, and according to the body movement sensed or recognized by the sensing module, the control module controls the sensor or the infusion module to execute corresponding functional instructions.
  • body movements are directly used as functional instructions, avoiding the user from searching the inputting position of the functional instructions on the remote device, which is simple and convenient, and improves the user experience as well.
  • the closed-loop artificial pancreas controlled by body movements further includes a body movement verification module which is connected to the sensing module.
  • the movement verification module is used to confirm whether the user's body movements meet the standard or the requirements preset in this module, improving the safety of the artificial pancreas.
  • the body movements include one or a combination of jumping, squatting, leg movements, arm movements, taps on the sensing module, bending over, torso twist, special way of walking.
  • body movements There are many types of body movements which are relatively easy to be performed by users.
  • the combination of multiple body movements also improves the flexibility in the manufacturing process in the factory or the operating process for user. And generally, the more types of body movements included by one functional instruction, the safer of the artificial pancreas while executing them.
  • the linear acceleration sensor is a three-axis linear acceleration sensor.
  • the three-axis linear acceleration sensor can detect acceleration changes in the three directions of the X, Y, and Z axes, which has the advantage of quickly and accurately detecting body movements and also improves the sensitivity of movement detection.
  • the sensing module, control module, sensor and infusion module are arranged in a single device.
  • the integrated design of multiple modules in a single device can improve the integration degree of the artificial pancreas, which reduces the number of structures pasted on the user skin, facilitates the user's daily physical activities, and further enhances the user experience.
  • FIG. 1 a is a schematic view of a closed-loop artificial pancreas module controlled by body movements according to an embodiment of the present invention
  • FIG. 1 B is a schematic cross-sectional view of a closed-loop artificial pancreas controlled by body movements according to an embodiment of the present invention
  • FIG. 2 a - FIG. 2 b are schematic views of the module structure of the artificial pancreas including a movement verification module according to two different embodiments of the present invention
  • FIG. 3 a is a schematic view of a module structure of a control module including a first sub-control module and a second sub-control module according to another embodiment of the present invention
  • FIG. 3 b is a schematic cross-sectional view of an infusion module and a sensor according to another embodiment of the present invention.
  • FIG. 4 a is a schematic view of a module structure of a sensing module including a first sub-sensing module and a second sub-sensing module according to another embodiment of the present invention
  • FIG. 4 b is a schematic cross-sectional view of an infusion module and a sensor according to another embodiment of the present invention.
  • the artificial pancreas in the prior art requires the user to find a inputting position on a remote device and manually inputting functional instructions, which worsens user experience.
  • the present invention provides a closed-loop artificial pancreas controlled by body movements, which is provided with a sensing module for sensing body movements directly used as functional instructions, thereby improving user experience.
  • FIG. 1 a is a schematic view of a closed-loop artificial pancreas module controlled by body movements according to an embodiment of the present invention.
  • FIG. 1 b is a schematic cross-sectional view of a closed-loop artificial pancreas controlled by body movements according to an embodiment of the present invention.
  • the module 100 is a sensing module which is used to sense or recognize body movements of the user.
  • the sensing module 100 is provided with a linear acceleration sensor or a gyroscope sensor which can not only sensitively and accurately sense the user's body movement, but also can recognize the type of the user's body movement.
  • the linear acceleration sensor is a three-axis linear acceleration sensor which can detect small acceleration changes in the three directions of X, Y, and Z axes. It has the advantage of enhanced sensitivity for movement detection and is capable of rapid detection of body movements.
  • the sensing module 100 is a gyroscope sensor.
  • the gyroscope sensor can accurately detect the user's rotational body movements such as, torso twist, special way of walking and circling.
  • a linear acceleration sensor and a gyroscope sensor are provided in the sensing module 100 .
  • the linear acceleration sensor is a three-axis linear acceleration sensor.
  • only a linear acceleration sensor is provided in the sensing module 100 , which is not specifically limited here.
  • Module 101 is a control module which is used to control the sensor 102 or the infusion module 103 to execute corresponding functional instructions.
  • the control module 101 and the sensing module 100 are operatively connected to facilitate the transmission of instruction signals between the two modules.
  • the term “operatively connected” means that the control module 101 can directly or indirectly obtain body movement information from the sensing module 100 , thereby controlling the sensor 102 or the infusion module 103 to perform the corresponding functional instructions, which will be described below in conjunction with different embodiments.
  • the sensing module 100 and the control module 101 are electrically connected.
  • the electrical connection between the two not only facilitates structural design, but also reduces power consumption compared with the wireless connection.
  • the closed-loop artificial pancreas of the present invention also includes a sensor 102 and an infusion module 103 .
  • the sensor 102 is used to detect blood glucose (BG) concentration while the infusion module 103 is used for infusing drug into the user's body. Therefore, the infusion module 103 includes structures required for drug infusion (like insulin or glucagon), such as including but not limited to a drug storage unit, a driving unit, a piston position detection unit, a power supply, and the like.
  • the power supply can also be provided outside the infusion module, which is not specifically limited herein.
  • the sensor 102 and the infusion module 103 are respectively connected to the control module 101 , preferably electrically connected. Therefore, the control module 101 can separately or simultaneously control the sensor 102 and the infusion module 103 to execute corresponding functional instructions, as shown in FIG. 1 a.
  • connection means that the control module 101 and the sensor 102 or the infusion unit 103 are electrically or wirelessly connected to each other.
  • connection of any two modules or any two structures hereinafter has the same meaning.
  • the functional instructions include the functions that the sensor 102 can perform, such as including but not limited to calibrating the sensor, activating or deactivating the sensor, adjusting the BG concentration alarm threshold; also including those that the infusion module 103 can perform, such as including but not limited to infusing drug or stopping infusing drug, priming the infusion needle, puncturing or retracting the infusion needle, adjusting the infusion speed or infusion mode, adjusting the amount of drug infusion, and starting the event. It also includes functions that can be performed by both the sensor 102 and the infusion module 103 , such as including but not limited to switching the user's physical state, connecting or disconnecting the remote device.
  • the BG concentration alarm threshold is used to produce an alert to the user when the blood glucose is too high or too low.
  • the infusion of drugs includes basal dose infusion and bolus dose infusion. Adjusting the infusion speed or the infusion mode means that according to the user's physical state, the user reasonably selects or the artificial pancreas auto-selects the driving type or the driving mode of the driving unit in the infusion module 103 , thereby achieving the goal of optimal BG controlling.
  • Connecting or disconnecting the remote device means that the user can choose whether to connect the sensor 102 or the infusion module 103 to the remote device according to actual needs. Switching the user's physical state means that the user switches from the sitting state to the sleeping state, or from the sleeping state to the wake-up state, etc.
  • Starting the event means indicating the user's meal event, sports event, or bathing event.
  • the functions performed by the closed-loop artificial pancreas controlled by body movements in the embodiment of the present invention are controlled by the user's body movements. Therefore, in the embodiment of the present invention, different body movements of the user represent different functional instructions.
  • the body movement includes one or a combination of jumping, squatting, leg movements, arm movements, taps on the sensing module, bending over, torso twist, special way of walking. Compared with manual inputting, body movements are much easier to implement, which improves the user experience.
  • the combination of multiple body movements also improves the flexibility in the manufacturing process in the factory or the operating process for user. And generally, the more types of body movements included by one functional instructions, the safer of the artificial pancreas while executing them.
  • tapping the sensing module 100 not only includes direct contact with the sensing module 100 , but also includes indirect contact or non-contact.
  • the user can tap the clothing around the sensing module 100 .
  • Leg movements include, but are not limited to, raising the leg and shaking the leg.
  • Arm movements include, but are not limited to, vibrating arms and swinging arms.
  • Special walking methods include, but are not limited to, forward and backward walking, circle walking and zigzag.
  • the functional instructions are represented by single movement or a combination of multiple movements among the above-mentioned body movements, and no limit is set on the frequency of a certain body movement.
  • the functional instruction for priming the infusion needle is to tap the sensing module 100 three times. Tapping three times is chosen instead of one, two, or more than three times, which avoids the interference caused by accidental movements, and is more convenient and more user-friendly than tapping more than three times.
  • the functional instruction for the basal dose infusion is that the user bends down first, and then twists the torso twice.
  • the functional instruction for activating the sensing module 100 is zigzagging.
  • the sensing module 100 , the control module 101 , the sensor 102 and the infusion module 103 are arranged in a single device 10 which is pasted on a certain position of the user's skin, as shown in FIG. 1 B .
  • the integrated design of the above-mentioned modules in a single device 10 can improve the integration degree of the artificial pancreas, reducing the number of structures pasted on the user skin, facilitating the user's daily physical activities, and further enhancing the user experience.
  • FIG. 2 a - FIG. 2 b are schematic views of the module structure of the artificial pancreas including a movement verification module 204 according to different embodiments of the present invention.
  • the movement verification module 204 is connected with the sensing module 200 and is used to confirm whether the user's body movements meet the standard or the requirements (such as speed, intensity, or frequency preset), so as to improve the safety of the artificial pancreas.
  • the sensing module 200 detects a user's specific body movement which does not meet the preset requirements or the standard, the artificial pancreas will issue a specific form of alarm (such as light, sound, vibration, etc.), allowing the user to perform more standard body movement again.
  • the artificial pancreas can also send out a specific form of warning (such as light, sound, vibration, etc.).
  • the embodiment of the present invention does not specifically limit the position of the movement verification module 204 and its connection relationship with other modules, as long as the condition for the movement verification module 204 to be connected to the sensing module 200 can be met.
  • the movement verification module 204 is provided between the sensing module 200 and the control module 201 , as shown in FIG. 2 a. Therefore, after the sensing module 200 senses or recognizes the user's body movement, the movement verification module 204 confirms whether the movement meets the requirements or the standard. If met, the control module 201 receives the body movement information indirectly from the sensing module 200 , thereby controlling the sensor 202 or the infusion module 203 to execute the corresponding functional instruction. At this time, sensing module 200 is operatively connected with the control module 201 .
  • the movement verification module 204 may also only be connected to the sensing module 200 , as shown in FIG. 2 b.
  • the control module 201 can obtain the corresponding instruction information directly, and then control the sensor 202 or the infusion module 203 to execute the corresponding functional instruction.
  • FIG. 3 a is a schematic view of a module structure of a control module 301 including a first sub-control module 301 a and a second sub-control module 301 b according to another embodiment of the present invention.
  • FIG. 3 b is a schematic cross-sectional view of the infusion module 303 and the sensor 302 according to another embodiment of the present invention.
  • the control module 301 includes a first sub-control module 301 a and a second sub-control module 301 b which are connected to the sensor 302 and the infusion module 303 , respectively.
  • the wireless connection between the first sub-control module 301 a and the second sub-control module 301 b is shown in FIG. 3 a.
  • the first sub-control module 301 a is a transmitter while the second sub-control module 301 b is a pump base.
  • the transmitter and the pump base can be connected to each other through wireless signals.
  • the sensing module 300 is electrically connected to the pump base. If one body movement related to the functional instruction of the infusion module 303 is sensed by the sensing module 300 , the second sub-control module 301 b can obtain the body movement information directly and control the infusion module 303 to execute the corresponding functional instruction. Similarly, if the body movement related to the functional instruction of the sensor 302 is sensed by the sensing module 300 , the second sub-control module 301 b transmits the corresponding body movement information to the first sub-control module 301 a through wireless signals. Therefore, the first sub-control module 301 a receives body movement information indirectly, and then controls the sensor 302 to execute corresponding functional instructions.
  • the sensing module 300 is electrically connected to the transmitter. If the body movement representing the functional instruction is sensed, the first sub-control module 301 a can control the sensor 302 to execute it. Or the second sub-control module 301 b receives the wireless signal from the first sub-control module 301 a , and then controls the infusion module 303 to execute the corresponding functional instruction.
  • FIG. 4 a is a schematic view of a module structure of a sensing module 400 including a first sub-sensing module 400 a and a second sub-sensing module 400 b according to another embodiment of the present invention.
  • FIG. 4 b is a schematic cross-sectional view of an infusion module 403 and a sensor 402 according to another embodiment of the present invention.
  • the sensing module 400 includes a first sub-sensing module 400 a and a second sub-sensing module 400 b .
  • the control module 401 includes a first sub-control module 401 a and a second sub-control module 401 b .
  • the first sub-sensing module 400 a and the second sub-sensing module 400 b are respectively connected to the first sub-control module 401 a and the second sub-control module 401 b .
  • control module 401 a can obtain the body movement information of the sensing module 400 a to control the sensor 402 to execute corresponding functional instructions.
  • control module 401 b can obtain the body movement information of the sensing module 400 b , and then control the infusion module 403 to execute the corresponding functional instructions.
  • the user can make targeted body movements on the sensor 402 or the infusion module 403 , making it easier for the artificial pancreas to sense or recognize the corresponding body movements, and complete the corresponding function more efficiently.
  • the first sub-control module 401 a and the second sub-control module 401 b are wirelessly connected. Since different functional instructions correspond to different body movements, when the second sub-sensing module 400 b senses a body movement requiring the sensor 402 to execute the functional instruction, the second sub-control module 401 b wirelessly transmits the corresponding body movement information to the first sub-control module 401 a . Similarly, when the first sub-sensing module 400 a senses a body movement that requires the infusion module 403 to execute, the first sub-control module 401 a wirelessly transmits the corresponding body movement information to the second sub-control module 401 a , as shown in FIG. 4 b. Similarly, certain body movements can be sensed and recognized by the first sub-sensing module 400 a and the second sub-sensing module 400 b at the same time, such as body rotation or body squatting.
  • the present invention discloses a closed-loop artificial pancreas controlled by body movements. If the user's body movement, as a functional instruction, is sensed by a sensing module, the control module can control the sensor or the infusion module to execute the corresponding function without the user manually inputting the functional instruction on the remote device, enhancing the user experience.

Abstract

A closed-loop artificial pancreas controlled by body movements, which includes: a sensor used for detecting blood glucose concentration; an infusion module used for infusing drug into the body; a control module connected to the sensor and the infusion module, respectively; and a sensing module operatively connected to the control module and used to sense or recognize the user's body movements, and different body movements represent different functional instructions, and according to the body movement sensed or recognized by the sensing module, the control module controls the sensor or the infusion module to execute corresponding functional instructions, which enhances the user experience.

Description

    TECHNICAL FIELD
  • The present invention mainly relates to the field of medical instruments, in particular to a closed-loop artificial pancreas controlled by body movements.
    • BACKGROUND
  • The pancreas in a normal person can automatically monitor the amount of glucose in the blood and automatically secrete the required dosage of insulin/glucagon. However, for diabetic patients, the function of the pancreas is abnormal, and the pancreas cannot normally secrete required dosage of insulin. Therefore, diabetes is a metabolic disease caused by abnormal pancreatic function and also a lifelong disease. At present, medical technology cannot cure diabetes, but can only control the onset and development of diabetes and its complications by stabilizing blood glucose.
  • Patients with diabetes need to check their blood glucose before injecting insulin into the body. At present, most of the detection methods can continuously detect blood glucose, and send the blood glucose data to the remote device in real time for the user to view. This detection method is called Continuous Glucose Monitoring (CGM), which requires the detection device to be attached to the surface of the patients' skin, and the sensor carried by the device is inserted into the subcutaneous tissue fluid for testing. According to the blood glucose (BG) level, the infusion device, as a closed-loop or semi-closed-loop artificial pancreas, injects the currently required insulin dose.
  • At present, when a user uses a closed-loop artificial pancreas, he needs to find different inputting positions on the remote device to manually input functional instruction, and then control the CGM or the infusion pump to perform corresponding functions. This inputting process is cumbersome, which worsens the user experience.
  • Therefore, in the prior art, there is an urgent need for a closed-loop artificial pancreas that simplifies the functional instruction inputting process and has a better user experience.
    • BRIEF SUMMARY OF THE INVENTION
  • The embodiment of the present invention discloses a closed-loop artificial pancreas controlled by body movements. If the user's body movement, as a functional instruction, is sensed by a sensing module, the control module can control the sensor or the infusion module to execute the corresponding function without the user manually inputting the functional instruction on the remote device, enhancing the user experience.
  • The invention discloses a closed-loop artificial pancreas controlled by body movements, which comprises: a sensor used for detecting blood glucose concentration; an infusion module used for infusing drug into the body; a control module connected to the sensor and the infusion module, respectively; and a sensing module operatively connected to the control module and used to sense or recognize the user's body movements, and different body movements represent different functional instructions, and according to the body movement sensed or recognized by the sensing module, the control module controls the sensor or the infusion module to execute corresponding functional instructions.
  • According to one aspect of the present invention, functional instructions include calibrating the sensor, activating or deactivating the sensor, adjusting the blood glucose concentration alarm threshold, infusing drug or stopping infusing drug, priming the infusion needle, puncturing or retracting the infusion needle, adjusting the infusion speed or infusion mode, adjusting the amount of drug infusion, turning on or off the alarm, connecting or disconnecting the remote device, switching the user's physical state, or starting the event.
  • According to one aspect of the invention, the drug includes insulin or glucagon.
  • According to one aspect of the present invention, the control module includes a first sub-control module connected to the sensor and a second sub-control module connected to the infusion module, and the first sub-control module and the second sub-control module are wirelessly connected, and the sensing module is connected to the first sub-control module or the second sub-control module.
  • According to one aspect of the present invention, the sensor and the infusion module are pasted on different positions of the user's skin, the first sub-control module is a transmitter while the second sub-control module is a pump base.
  • According to one aspect of the present invention, the sensing module includes a first sub-sensing module connected to the first sub-control module and a second sub-sensing module connected to the second sub-control module.
  • According to one aspect of the present invention, it further includes a body movement verification module which is connected to the sensing module.
  • According to one aspect of the present invention, the body movements include one or a combination of jumping, squatting, leg movements, arm movements, taps on the sensing module, bending over, torso twist, special way of walking.
  • According to one aspect of the present invention, a linear acceleration sensor or a gyroscope sensor is provided in the sensing module.
  • According to one aspect of the present invention, the linear acceleration sensor is a three-axis linear acceleration sensor.
  • According to one aspect of the present invention, the sensing module, the control module, the sensor and the infusion module are arranged in a single device.
  • Compared with the prior art, the technical solution of the present invention has the following advantages:
  • In the closed-loop artificial pancreas controlled by body movements disclosed in the present invention, a control module connected to the sensor and the infusion module, respectively; and a sensing module operatively connected to the control module and used to sense or recognize the user's body movements, and different body movements represent different functional instructions, and according to the body movement sensed or recognized by the sensing module, the control module controls the sensor or the infusion module to execute corresponding functional instructions. Compared with manual inputting, body movements are directly used as functional instructions, avoiding the user from searching the inputting position of the functional instructions on the remote device, which is simple and convenient, and improves the user experience as well.
  • Furthermore, the closed-loop artificial pancreas controlled by body movements further includes a body movement verification module which is connected to the sensing module. The movement verification module is used to confirm whether the user's body movements meet the standard or the requirements preset in this module, improving the safety of the artificial pancreas.
  • Furthermore, the body movements include one or a combination of jumping, squatting, leg movements, arm movements, taps on the sensing module, bending over, torso twist, special way of walking. There are many types of body movements which are relatively easy to be performed by users. At the same time, the combination of multiple body movements also improves the flexibility in the manufacturing process in the factory or the operating process for user. And generally, the more types of body movements included by one functional instruction, the safer of the artificial pancreas while executing them.
  • Furthermore, the linear acceleration sensor is a three-axis linear acceleration sensor. The three-axis linear acceleration sensor can detect acceleration changes in the three directions of the X, Y, and Z axes, which has the advantage of quickly and accurately detecting body movements and also improves the sensitivity of movement detection.
  • Furthermore, the sensing module, control module, sensor and infusion module are arranged in a single device. The integrated design of multiple modules in a single device can improve the integration degree of the artificial pancreas, which reduces the number of structures pasted on the user skin, facilitates the user's daily physical activities, and further enhances the user experience.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 a is a schematic view of a closed-loop artificial pancreas module controlled by body movements according to an embodiment of the present invention;
  • FIG. 1B is a schematic cross-sectional view of a closed-loop artificial pancreas controlled by body movements according to an embodiment of the present invention;
  • FIG. 2 a -FIG. 2 b are schematic views of the module structure of the artificial pancreas including a movement verification module according to two different embodiments of the present invention;
  • FIG. 3 a is a schematic view of a module structure of a control module including a first sub-control module and a second sub-control module according to another embodiment of the present invention;
  • FIG. 3 b is a schematic cross-sectional view of an infusion module and a sensor according to another embodiment of the present invention;
  • FIG. 4 a is a schematic view of a module structure of a sensing module including a first sub-sensing module and a second sub-sensing module according to another embodiment of the present invention;
  • FIG. 4 b is a schematic cross-sectional view of an infusion module and a sensor according to another embodiment of the present invention.
    •  DETAILED DESCRIPTION
  • As mentioned above, the artificial pancreas in the prior art requires the user to find a inputting position on a remote device and manually inputting functional instructions, which worsens user experience.
  • Researches have found that the cause of the above problems is that the artificial pancreas in prior arts does not have a sensing structure sensing the user's body movements, therefore, the body movements cannot be used as functional instructions.
  • In order to solve this problem, the present invention provides a closed-loop artificial pancreas controlled by body movements, which is provided with a sensing module for sensing body movements directly used as functional instructions, thereby improving user experience.
  • Various exemplary embodiments of the present invention will now be described in detail with reference to the drawings. The relative arrangement of the components and the steps, numerical expressions and numerical values set forth in the embodiments are not to be construed as limiting the scope of the invention.
  • In addition, it should be understood that, for ease of description, the dimensions of the various components shown in the figures are not necessarily drawn in the actual scale relationship, for example, the thickness, width, length or distance of certain units may be exaggerated relative to other structures.
  • The following description of the exemplary embodiments is merely illustrative, and is not intended to be in any way limiting the invention and its application or use. The techniques, methods and devices that are known to those of ordinary skill in the art may not be discussed in detail, but such techniques, methods and devices should be considered as part of the specification.
  • It should be noted that similar reference numerals and letters indicate similar items in the following figures. Therefore, once an item is defined or illustrated in a drawing, it will not be discussed further in following description of the drawings.
  • FIG. 1 a is a schematic view of a closed-loop artificial pancreas module controlled by body movements according to an embodiment of the present invention. FIG. 1 b is a schematic cross-sectional view of a closed-loop artificial pancreas controlled by body movements according to an embodiment of the present invention.
  • The module 100 is a sensing module which is used to sense or recognize body movements of the user.
  • The sensing module 100 is provided with a linear acceleration sensor or a gyroscope sensor which can not only sensitively and accurately sense the user's body movement, but also can recognize the type of the user's body movement.
  • In an embodiment of the present invention, the linear acceleration sensor is a three-axis linear acceleration sensor which can detect small acceleration changes in the three directions of X, Y, and Z axes. It has the advantage of enhanced sensitivity for movement detection and is capable of rapid detection of body movements.
  • In another embodiment of the present invention, the sensing module 100 is a gyroscope sensor. The gyroscope sensor can accurately detect the user's rotational body movements such as, torso twist, special way of walking and circling.
  • Preferably, in the embodiment of the present invention, a linear acceleration sensor and a gyroscope sensor are provided in the sensing module 100. And the linear acceleration sensor is a three-axis linear acceleration sensor.
  • In another embodiment of the present invention, only a linear acceleration sensor is provided in the sensing module 100, which is not specifically limited here.
  • Module 101 is a control module which is used to control the sensor 102 or the infusion module 103 to execute corresponding functional instructions.
  • The control module 101 and the sensing module 100 are operatively connected to facilitate the transmission of instruction signals between the two modules. Here, the term “operatively connected” means that the control module 101 can directly or indirectly obtain body movement information from the sensing module 100, thereby controlling the sensor 102 or the infusion module 103 to perform the corresponding functional instructions, which will be described below in conjunction with different embodiments.
  • Preferably, in the embodiment of the present invention, the sensing module 100 and the control module 101 are electrically connected. The electrical connection between the two not only facilitates structural design, but also reduces power consumption compared with the wireless connection.
  • The closed-loop artificial pancreas of the present invention also includes a sensor 102 and an infusion module 103. The sensor 102 is used to detect blood glucose (BG) concentration while the infusion module 103 is used for infusing drug into the user's body. Therefore, the infusion module 103 includes structures required for drug infusion (like insulin or glucagon), such as including but not limited to a drug storage unit, a driving unit, a piston position detection unit, a power supply, and the like. In some embodiments of the present invention, the power supply can also be provided outside the infusion module, which is not specifically limited herein.
  • The sensor 102 and the infusion module 103 are respectively connected to the control module 101, preferably electrically connected. Therefore, the control module 101 can separately or simultaneously control the sensor 102 and the infusion module 103 to execute corresponding functional instructions, as shown in FIG. 1 a.
  • Herein, the term “connected” means that the control module 101 and the sensor 102 or the infusion unit 103 are electrically or wirelessly connected to each other. And the “connected” of any two modules or any two structures hereinafter has the same meaning.
  • Obviously, in the embodiment of the present invention, the functional instructions include the functions that the sensor 102 can perform, such as including but not limited to calibrating the sensor, activating or deactivating the sensor, adjusting the BG concentration alarm threshold; also including those that the infusion module 103 can perform, such as including but not limited to infusing drug or stopping infusing drug, priming the infusion needle, puncturing or retracting the infusion needle, adjusting the infusion speed or infusion mode, adjusting the amount of drug infusion, and starting the event. It also includes functions that can be performed by both the sensor 102 and the infusion module 103, such as including but not limited to switching the user's physical state, connecting or disconnecting the remote device.
  • It should be noted here that the BG concentration alarm threshold is used to produce an alert to the user when the blood glucose is too high or too low. The infusion of drugs includes basal dose infusion and bolus dose infusion. Adjusting the infusion speed or the infusion mode means that according to the user's physical state, the user reasonably selects or the artificial pancreas auto-selects the driving type or the driving mode of the driving unit in the infusion module 103, thereby achieving the goal of optimal BG controlling. Connecting or disconnecting the remote device means that the user can choose whether to connect the sensor 102 or the infusion module 103 to the remote device according to actual needs. Switching the user's physical state means that the user switches from the sitting state to the sleeping state, or from the sleeping state to the wake-up state, etc. Starting the event means indicating the user's meal event, sports event, or bathing event.
  • The functions performed by the closed-loop artificial pancreas controlled by body movements in the embodiment of the present invention are controlled by the user's body movements. Therefore, in the embodiment of the present invention, different body movements of the user represent different functional instructions. In the embodiment of the present invention, the body movement includes one or a combination of jumping, squatting, leg movements, arm movements, taps on the sensing module, bending over, torso twist, special way of walking. Compared with manual inputting, body movements are much easier to implement, which improves the user experience. At the same time, the combination of multiple body movements also improves the flexibility in the manufacturing process in the factory or the operating process for user. And generally, the more types of body movements included by one functional instructions, the safer of the artificial pancreas while executing them.
  • It should be noted here that tapping the sensing module 100 not only includes direct contact with the sensing module 100, but also includes indirect contact or non-contact. For example, the user can tap the clothing around the sensing module 100. Leg movements include, but are not limited to, raising the leg and shaking the leg. Arm movements include, but are not limited to, vibrating arms and swinging arms. Special walking methods include, but are not limited to, forward and backward walking, circle walking and zigzag.
  • In the embodiment of the present invention, the functional instructions are represented by single movement or a combination of multiple movements among the above-mentioned body movements, and no limit is set on the frequency of a certain body movement. Preferably, in the embodiment of the present invention, the functional instruction for priming the infusion needle is to tap the sensing module 100 three times. Tapping three times is chosen instead of one, two, or more than three times, which avoids the interference caused by accidental movements, and is more convenient and more user-friendly than tapping more than three times. In another embodiment of the present invention, the functional instruction for the basal dose infusion is that the user bends down first, and then twists the torso twice. In still another embodiment of the present invention, the functional instruction for activating the sensing module 100 is zigzagging.
  • Preferably, in the embodiment of the present invention, the sensing module 100, the control module 101, the sensor 102 and the infusion module 103 are arranged in a single device 10 which is pasted on a certain position of the user's skin, as shown in FIG. 1B. The integrated design of the above-mentioned modules in a single device 10 can improve the integration degree of the artificial pancreas, reducing the number of structures pasted on the user skin, facilitating the user's daily physical activities, and further enhancing the user experience.
  • FIG. 2 a -FIG. 2 b are schematic views of the module structure of the artificial pancreas including a movement verification module 204 according to different embodiments of the present invention.
  • The movement verification module 204 is connected with the sensing module 200 and is used to confirm whether the user's body movements meet the standard or the requirements (such as speed, intensity, or frequency preset), so as to improve the safety of the artificial pancreas. When the sensing module 200 detects a user's specific body movement which does not meet the preset requirements or the standard, the artificial pancreas will issue a specific form of alarm (such as light, sound, vibration, etc.), allowing the user to perform more standard body movement again. Similarly, when the body movement meets the requirements or the standard, the artificial pancreas can also send out a specific form of warning (such as light, sound, vibration, etc.).
  • The embodiment of the present invention does not specifically limit the position of the movement verification module 204 and its connection relationship with other modules, as long as the condition for the movement verification module 204 to be connected to the sensing module 200 can be met. Preferably, in the embodiment of the present invention, the movement verification module 204 is provided between the sensing module 200 and the control module 201, as shown in FIG. 2 a. Therefore, after the sensing module 200 senses or recognizes the user's body movement, the movement verification module 204 confirms whether the movement meets the requirements or the standard. If met, the control module 201 receives the body movement information indirectly from the sensing module 200, thereby controlling the sensor 202 or the infusion module 203 to execute the corresponding functional instruction. At this time, sensing module 200 is operatively connected with the control module 201.
  • In another embodiment of the present invention, the movement verification module 204 may also only be connected to the sensing module 200, as shown in FIG. 2 b. When the movement verification module 204 confirms that the body movement meets the requirements or the standard, the control module 201 can obtain the corresponding instruction information directly, and then control the sensor 202 or the infusion module 203 to execute the corresponding functional instruction.
  • For the principle and manner of controlling the sensor 202 and the infusion module 203 by the control module 201, please refer to the foregoing description, which will not be repeated here.
  • FIG. 3 a is a schematic view of a module structure of a control module 301 including a first sub-control module 301 a and a second sub-control module 301 b according to another embodiment of the present invention. FIG. 3 b is a schematic cross-sectional view of the infusion module 303 and the sensor 302 according to another embodiment of the present invention.
  • In the embodiment of the present invention, the sensor 302 and the infusion module 303 are respectively pasted on different positions of the user's skin. Therefore, the control module 301 includes a first sub-control module 301 a and a second sub-control module 301 b which are connected to the sensor 302 and the infusion module 303, respectively. The wireless connection between the first sub-control module 301 a and the second sub-control module 301 b is shown in FIG. 3 a.
  • Preferably, in the embodiment of the present invention, the first sub-control module 301 a is a transmitter while the second sub-control module 301 b is a pump base. The transmitter and the pump base can be connected to each other through wireless signals.
  • In the embodiment of the present invention, the sensing module 300 is electrically connected to the pump base. If one body movement related to the functional instruction of the infusion module 303 is sensed by the sensing module 300, the second sub-control module 301 b can obtain the body movement information directly and control the infusion module 303 to execute the corresponding functional instruction. Similarly, if the body movement related to the functional instruction of the sensor 302 is sensed by the sensing module 300, the second sub-control module 301 b transmits the corresponding body movement information to the first sub-control module 301 a through wireless signals. Therefore, the first sub-control module 301 a receives body movement information indirectly, and then controls the sensor 302 to execute corresponding functional instructions.
  • Similarly, in another embodiment of the present invention, the sensing module 300 is electrically connected to the transmitter. If the body movement representing the functional instruction is sensed, the first sub-control module 301 a can control the sensor 302 to execute it. Or the second sub-control module 301 b receives the wireless signal from the first sub-control module 301 a, and then controls the infusion module 303 to execute the corresponding functional instruction.
  • FIG. 4 a is a schematic view of a module structure of a sensing module 400 including a first sub-sensing module 400 a and a second sub-sensing module 400 b according to another embodiment of the present invention. FIG. 4 b is a schematic cross-sectional view of an infusion module 403 and a sensor 402 according to another embodiment of the present invention.
  • In the embodiment of the present invention, the sensor 402 and the infusion module 403 are respectively pasted on different positions of the user's skin. The sensing module 400 includes a first sub-sensing module 400 a and a second sub-sensing module 400 b. At this time, the control module 401 includes a first sub-control module 401 a and a second sub-control module 401 b. The first sub-sensing module 400 a and the second sub-sensing module 400 b are respectively connected to the first sub-control module 401 a and the second sub-control module 401 b. At the same time, the control module 401 a can obtain the body movement information of the sensing module 400 a to control the sensor 402 to execute corresponding functional instructions. Similarly, the control module 401 b can obtain the body movement information of the sensing module 400 b, and then control the infusion module 403 to execute the corresponding functional instructions. After setting the first sub-sensing module 400 a and the second sub-sensing module 400 b, the user can make targeted body movements on the sensor 402 or the infusion module 403, making it easier for the artificial pancreas to sense or recognize the corresponding body movements, and complete the corresponding function more efficiently.
  • It should be noted that in another embodiment of the present invention, the first sub-control module 401 a and the second sub-control module 401 b are wirelessly connected. Since different functional instructions correspond to different body movements, when the second sub-sensing module 400 b senses a body movement requiring the sensor 402 to execute the functional instruction, the second sub-control module 401 b wirelessly transmits the corresponding body movement information to the first sub-control module 401 a. Similarly, when the first sub-sensing module 400 a senses a body movement that requires the infusion module 403 to execute, the first sub-control module 401 a wirelessly transmits the corresponding body movement information to the second sub-control module 401 a, as shown in FIG. 4 b. Similarly, certain body movements can be sensed and recognized by the first sub-sensing module 400 a and the second sub-sensing module 400 b at the same time, such as body rotation or body squatting.
  • In summary, the present invention discloses a closed-loop artificial pancreas controlled by body movements. If the user's body movement, as a functional instruction, is sensed by a sensing module, the control module can control the sensor or the infusion module to execute the corresponding function without the user manually inputting the functional instruction on the remote device, enhancing the user experience.
  • While the invention has been described in detail with reference to the specific embodiments of the present invention, it should be understood that it will be appreciated by those skilled in the art that the above embodiments may be modified without departing from the scope and spirit of the invention. The scope of the invention is defined by the appended claims.

Claims (11)

1. A closed-loop artificial pancreas controlled by body movements, comprising:
a sensor used for detecting a blood glucose concentration;
an infusion module used for infusing a drug into a body;
a control module connected to the sensor and the infusion module, respectively; and
a sensing module operatively connected to the control module and used to sense or recognize a user's body movements, and different body movements represent different functional instructions, and according to the body movements sensed or recognized by the sensing module, the control module controls the sensor or the infusion module to execute functional instructions, which correspond to the body movements.
2. The closed-loop artificial pancreas controlled by the body movements of claim 1, wherein
the functional instructions include calibrating the sensor, activating or deactivating the sensor, adjusting a blood glucose concentration alarm threshold, infusing the drug or stopping infusing the drug, priming a infusion needle, puncturing or retracting the infusion needle, adjusting a infusion speed ora infusion mode, adjusting the amount of drug infusion, turning on or off an alarm, connecting or disconnecting the remote device, switching the user's physical state, or starting an event.
3. The closed-loop artificial pancreas controlled by the body movements of claim 2, wherein
the drug includes an insulin or a glucagon.
4. The closed-loop artificial pancreas controlled by the body movements of claim 2, wherein
the control module includes a first sub-control module connected to the sensor and a second sub-control module connected to the infusion module, and the first sub-control module and the second sub-control module are wirelessly connected, and the sensing module is connected to the first sub-control module or the second sub-control module.
5. The closed-loop artificial pancreas controlled by the body movements of claim 4, wherein
the sensor and the infusion module are pasted on different positions of the user's skin, the first sub-control module is a transmitter while the second sub-control module is a pump base.
6. The closed-loop artificial pancreas controlled by the body movements of claim 4, wherein
the sensing module includes a first sub-sensing module connected to the first sub-control module and a second sub-sensing module connected to the second sub-control module.
7. The closed-loop artificial pancreas controlled by the body movements of claim 1, further comprising:
a body movement verification module which is connected to the sensing module.
8. The closed-loop artificial pancreas controlled by the body movements of claim 1, wherein
the body movements comprises one or a combination of jumping, squatting, leg movements, arm movements, taps on the sensing module, bending over, torso twist, special way of walking.
9. The closed-loop artificial pancreas controlled by the body movements of claim 8, wherein
a linear acceleration sensor or a gyroscope sensor is provided in the sensing module.
10. The closed-loop artificial pancreas controlled the by body movements of claim 9, wherein
the linear acceleration sensor is a three-axis linear acceleration sensor.
11. The closed-loop artificial pancreas controlled the by body movements of claim 1, wherein
the sensing module, the control module, the sensor and the infusion module are arranged in a single device.
US17/791,222 2020-01-21 2020-12-24 Closed-loop artificial pancreas controlled by body movements Pending US20230033130A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/073460 2020-01-21
PCT/CN2020/073460 WO2021146902A1 (en) 2020-01-21 2020-01-21 Medical device with safety verification and safety verification method thereof
PCT/CN2020/133734 WO2021147524A1 (en) 2020-01-21 2020-12-04 A closed-loop artificial pancreas controlled by body movements

Publications (1)

Publication Number Publication Date
US20230033130A1 true US20230033130A1 (en) 2023-02-02

Family

ID=76992685

Family Applications (5)

Application Number Title Priority Date Filing Date
US17/793,046 Pending US20230051295A1 (en) 2020-01-21 2020-01-21 Medical device with safety verification and safety verification method thereof
US17/791,222 Pending US20230033130A1 (en) 2020-01-21 2020-12-24 Closed-loop artificial pancreas controlled by body movements
US18/035,112 Pending US20240000398A1 (en) 2020-01-21 2021-07-08 Analyte detection system and continuous glucose monitoring device
US18/036,650 Pending US20240009386A1 (en) 2020-01-21 2021-08-23 Bilaterally driven drug infusion system
US18/035,525 Pending US20230330330A1 (en) 2020-01-21 2021-08-23 Unilaterally driven drug infusion system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US17/793,046 Pending US20230051295A1 (en) 2020-01-21 2020-01-21 Medical device with safety verification and safety verification method thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
US18/035,112 Pending US20240000398A1 (en) 2020-01-21 2021-07-08 Analyte detection system and continuous glucose monitoring device
US18/036,650 Pending US20240009386A1 (en) 2020-01-21 2021-08-23 Bilaterally driven drug infusion system
US18/035,525 Pending US20230330330A1 (en) 2020-01-21 2021-08-23 Unilaterally driven drug infusion system

Country Status (4)

Country Link
US (5) US20230051295A1 (en)
EP (5) EP4093460A4 (en)
CN (4) CN113208585B (en)
WO (5) WO2021146902A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20240050649A1 (en) * 2021-01-05 2024-02-15 Medtrum Technologies Inc. Skin patch drug infusion device
CN114432536A (en) * 2022-01-29 2022-05-06 深圳道远医疗科技有限公司 Integrated device and method for dynamic blood glucose monitoring and insulin injection fusion
CN115089808A (en) * 2022-07-14 2022-09-23 湖南千山医疗器械有限公司 Detachable liquid medicine infusion device
CN115105679A (en) * 2022-07-14 2022-09-27 湖南千山医疗器械有限公司 Drive reset type liquid medicine infusion device

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050238507A1 (en) * 2002-04-23 2005-10-27 Insulet Corporation Fluid delivery device
EP1535637A1 (en) * 2003-11-28 2005-06-01 Woo Young Medical Co., Ltd. Automatic dose infusion apparatus
US20060030836A1 (en) * 2004-08-05 2006-02-09 Woo Young Medical Co., Ltd. Automatic dose infusion apparatus and method of controlling the same
US7935104B2 (en) * 2005-11-07 2011-05-03 Medingo, Ltd. Systems and methods for sustained medical infusion and devices related thereto
US10154804B2 (en) * 2007-01-31 2018-12-18 Medtronic Minimed, Inc. Model predictive method and system for controlling and supervising insulin infusion
KR100904096B1 (en) * 2007-07-06 2009-06-23 이지의료정보 주식회사 Insulin injection apparatus and working method thereof
US8630694B2 (en) * 2007-08-20 2014-01-14 Mallinckrodt Llc Medical imaging system and fluid-driven injector
US7935076B2 (en) * 2007-09-07 2011-05-03 Asante Solutions, Inc. Activity sensing techniques for an infusion pump system
US8380314B2 (en) * 2007-09-26 2013-02-19 Medtronic, Inc. Patient directed therapy control
US7922695B2 (en) * 2007-10-18 2011-04-12 Roche Diagnostics Operations, Inc. Drug delivery pump drive using linear piezoelectric motor
US20090163855A1 (en) * 2007-12-24 2009-06-25 Medtronic Minimed, Inc. Infusion system with adaptive user interface
DK2400882T3 (en) * 2009-02-26 2017-09-18 Dreamed Diabetes Ltd METHOD AND SYSTEM FOR AUTOMATIC MONITORING OF DIABETES-RELATED TREATMENTS
EP4227952A1 (en) * 2009-05-29 2023-08-16 University Of Virginia Patent Foundation System coordinator and modular architecture for open-loop and closed-loop control of diabetes
CN101816576A (en) * 2010-04-08 2010-09-01 广西威利方舟科技有限公司 Closed loop muscle relaxation iatrical effect monitoring and injecting method and closed loop muscle relaxation injecting device
US10561785B2 (en) * 2010-06-22 2020-02-18 Medtronic Minimed, Inc. Method and/or system for closed-loop control of glucose to a treatment range
US8543354B2 (en) * 2010-06-23 2013-09-24 Medtronic Minimed, Inc. Glucose sensor signal stability analysis
US9033878B2 (en) * 2010-10-28 2015-05-19 Medtronic Minimed, Inc. Glucose sensor signal reliability analysis
US9445757B2 (en) * 2010-12-29 2016-09-20 Medtronic Minimed, Inc. Glycemic health metric determination and application
EP2551784A1 (en) * 2011-07-28 2013-01-30 Roche Diagnostics GmbH Method of controlling the display of a dataset
US20130046281A1 (en) * 2011-08-17 2013-02-21 Jonathan C. Javitt Closed Loop Infusion Formulation Delivery System
US8827909B2 (en) * 2012-01-11 2014-09-09 General Electric Company Ultrasound probe
US10694983B2 (en) * 2012-01-19 2020-06-30 Medtronic Minimed, Inc. Method and/or system for assessing a patient's glycemic response
US9757510B2 (en) * 2012-06-29 2017-09-12 Animas Corporation Method and system to handle manual boluses or meal events for closed-loop controllers
IN2015DN00854A (en) * 2012-07-09 2015-06-12 Debiotech Sa
US9623179B2 (en) * 2012-08-30 2017-04-18 Medtronic Minimed, Inc. Safeguarding techniques for a closed-loop insulin infusion system
US20140128739A1 (en) * 2012-11-07 2014-05-08 General Electric Company Ultrasound imaging system and method
US9486578B2 (en) * 2012-12-07 2016-11-08 Animas Corporation Method and system for tuning a closed-loop controller for an artificial pancreas
WO2014202233A1 (en) * 2013-06-21 2014-12-24 Fresenius Vial Sas Method and control device for controlling the administration of insulin to a patient
BR112016006893A2 (en) * 2013-09-30 2017-08-01 Animas Corp methods for safe communication and pairing of an infusion medical device and a remote controller for such a medical device
CN203576512U (en) * 2013-11-04 2014-05-07 理康互联科技(北京)有限公司 Analyte sensing device
CN104622480B (en) * 2013-11-12 2017-12-05 上海移宇科技股份有限公司 Single needle integrated-type artificial pancreas
CN105979984B (en) * 2013-12-11 2019-10-18 美敦力迷你迈德公司 For assessing and/or controlling the predicted time of blood sugar condition
US9750877B2 (en) * 2013-12-11 2017-09-05 Medtronic Minimed, Inc. Predicted time to assess and/or control a glycemic state
WO2016181384A2 (en) * 2015-05-08 2016-11-17 Triple Jump Israel Ltd. Systems, apparatuses and methods for fluid infusion into a body
US10646650B2 (en) * 2015-06-02 2020-05-12 Illinois Institute Of Technology Multivariable artificial pancreas method and system
CN104958077A (en) * 2015-07-24 2015-10-07 珠海福尼亚医疗设备有限公司 Intelligent control close-loop artificial pancreas system
CN104983543B (en) * 2015-07-29 2016-08-24 张士勇 A kind of Intelligent lower limb rehabilitation training aids
US10201657B2 (en) * 2015-08-21 2019-02-12 Medtronic Minimed, Inc. Methods for providing sensor site rotation feedback and related infusion devices and systems
WO2017062508A1 (en) * 2015-10-05 2017-04-13 Mc10, Inc. Method and System for Neuromodulation and Stimulation
WO2017087888A1 (en) * 2015-11-18 2017-05-26 President And Fellows Of Harvard College Systems and methods for monitoring, managing, and treating asthma and anaphylaxis
US10716896B2 (en) * 2015-11-24 2020-07-21 Insulet Corporation Wearable automated medication delivery system
US9980140B1 (en) * 2016-02-11 2018-05-22 Bigfoot Biomedical, Inc. Secure communication architecture for medical devices
JP7075357B2 (en) * 2016-06-07 2022-05-25 コーニンクレッカ フィリップス エヌ ヴェ Operation control of wireless sensor
US10896245B2 (en) * 2016-08-29 2021-01-19 Bigfoot Biomedical, Inc. Network topology for insulin pump systems
WO2018058287A1 (en) * 2016-09-27 2018-04-05 Medtrum Technologies Inc. Delivery safety ensuring method and wearable medical system using the method
EP3323466B1 (en) * 2016-11-16 2024-04-03 ONWARD Medical N.V. An active closed-loop medical system
CN107049324B (en) * 2016-11-23 2019-09-17 深圳大学 A kind of judgment method and device of limb motion posture
EP4342378A2 (en) * 2016-12-27 2024-03-27 Dexcom, Inc. Systems and methods for patient monitoring using an hcp - specific device
CN108281200A (en) * 2016-12-30 2018-07-13 上海移宇科技股份有限公司 A kind of method of the adjustment algorithm in dynamic blood sugar monitoring system and the dynamic blood sugar monitoring system of application this method
EP3562395A4 (en) * 2016-12-30 2020-07-22 Medtrum Technologies Inc. System and method for closed loop control in artificial pancreas
CN108261585B (en) * 2016-12-30 2022-06-07 上海移宇科技股份有限公司 System and method for closed-loop control of artificial pancreas
RU2765171C2 (en) * 2017-07-07 2022-01-26 Нейродерм Лтд Apparatus for subcutaneous delivery of a fluid medicinal product
CN108245742A (en) * 2018-01-19 2018-07-06 苏州英诺迈医学科技服务有限公司 A kind of insulin injection device
US11158413B2 (en) * 2018-04-23 2021-10-26 Medtronic Minimed, Inc. Personalized closed loop medication delivery system that utilizes a digital twin of the patient
US11690537B2 (en) * 2018-05-04 2023-07-04 Dexcom, Inc. Systems and methods relating to an analyte sensor system having a battery located within a disposable base
WO2019246217A1 (en) * 2018-06-19 2019-12-26 President And Fellows Of Harvard College Deep learning assisted macronutrient estimation for feedforward-feedback control in artificial pancreas systems
US11097052B2 (en) * 2018-09-28 2021-08-24 Medtronic Minimed, Inc. Insulin infusion device with configurable target blood glucose value for automatic basal insulin delivery operation
WO2020133405A1 (en) * 2018-12-29 2020-07-02 深圳市大疆创新科技有限公司 Method and device for controlling ground remote control robot
WO2020233484A1 (en) * 2019-05-17 2020-11-26 Medtrum Technologies Inc. Drug infusion device with multiple infusion modes
CN113543823B (en) * 2019-05-17 2023-12-15 上海移宇科技有限公司 Drug infusion device
US20220118176A1 (en) * 2019-05-17 2022-04-21 Medtrum Technologies Inc. Bilaterally driven drug infusion device with multiple infusion modes
WO2021031057A1 (en) * 2019-08-19 2021-02-25 Medtrum Technologies Inc. Sensing device

Also Published As

Publication number Publication date
EP4255529A1 (en) 2023-10-11
EP4093460A4 (en) 2023-09-27
US20240000398A1 (en) 2024-01-04
EP4093463A1 (en) 2022-11-30
EP4255298A1 (en) 2023-10-11
CN113208585B (en) 2023-05-09
CN113208585A (en) 2021-08-06
CN114588391A (en) 2022-06-07
WO2022116539A1 (en) 2022-06-09
EP4093463A4 (en) 2024-03-20
CN114588389A (en) 2022-06-07
CN114587352A (en) 2022-06-07
EP4255527A1 (en) 2023-10-11
US20240009386A1 (en) 2024-01-11
WO2021146902A1 (en) 2021-07-29
US20230051295A1 (en) 2023-02-16
WO2022116601A1 (en) 2022-06-09
US20230330330A1 (en) 2023-10-19
CN114588391B (en) 2024-01-09
WO2022116602A1 (en) 2022-06-09
EP4093460A1 (en) 2022-11-30
WO2021147524A1 (en) 2021-07-29

Similar Documents

Publication Publication Date Title
US20230033130A1 (en) Closed-loop artificial pancreas controlled by body movements
US20200237298A1 (en) Hypoglycemic Treatment Methods And Systems
US11534548B2 (en) System and method for a closed loop control in an artificial pancreas
US8308680B1 (en) Selective alarms for an infusion device
CN108261585B (en) System and method for closed-loop control of artificial pancreas
US11857764B2 (en) Automatic detection of un-bolused meals
JP2009504322A (en) Handheld controller device for infusion pump
JP2009504323A (en) Controller device for infusion pump
US20090163855A1 (en) Infusion system with adaptive user interface
US20060173406A1 (en) Algorithm sensor augmented bolus estimator for semi-closed loop infusion system
JP6548656B2 (en) Handset
US20090171269A1 (en) Infusion Device and Methods Therefor
CN101125086A (en) Closed-loop automatic controlling insulin-injecting system
JP2008535548A (en) Method and system for providing an integrated pharmaceutical infusion / specimen monitoring system
WO2008016486A2 (en) Watch controller for a medical device
US11412994B2 (en) System and method for algorithm adjustment applying motions sensor in a CGM system
JP2017504446A (en) Analyte concentration warning function for analyte sensor system
CN113223695A (en) Medical device with safety confirmation and safety confirmation method thereof
CN108281200A (en) A kind of method of the adjustment algorithm in dynamic blood sugar monitoring system and the dynamic blood sugar monitoring system of application this method
US20220133999A1 (en) Monitoring of physiological parameters with impedance measurement
CN217219747U (en) Insulin pump control system
US11839743B2 (en) Graphic user interface for automated infusate delivery

Legal Events

Date Code Title Description
AS Assignment

Owner name: MEDTRUM TECHNOLOGIES INC., CHINA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:YANG, CUIJUN;REEL/FRAME:060575/0121

Effective date: 20220616

STPP Information on status: patent application and granting procedure in general

Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION