US20230023867A1

US20230023867A1 - Identification of tumors and tissues

Info

Publication number: US20230023867A1
Application number: US17/854,909
Authority: US
Inventors: Mark G. Erlander; Xiao-Jun Ma
Original assignee: Biotheranostics Inc
Current assignee: Biotheranostics Inc
Priority date: 2005-06-03
Filing date: 2022-06-30
Publication date: 2023-01-26
Also published as: EP2365092A1; WO2006132971A3; US20070020655A1; ES2550652T3; KR20080104113A; AU2006255282A1; EP1899484B1; JP2008545431A; CN101297045A; US11430544B2; WO2006132971A9; WO2006132971A2; EP1899484A2; US20170286596A1; DK1899484T3; CA2610752A1

Abstract

The invention provides methods for the use of gene expression measurements to classify or identify tumors in samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples.

Description

RELATED APPLICATIONS

This application claims benefit of priority to U.S. Provisional Patent Application 60/687,174, filed Jun. 3, 2005, which is hereby incorporated by reference as if fully set forth.

FIELD OF THE INVENTION

This invention relates to the use of gene expression to classify human tumors. The classification is performed by use of gene expression profiles, or patterns, of about 5 to 49 expressed sequences that are correlated with tumors arising from certain tissues as well as being correlated with certain tumor types. The invention also provides for the use of about 5 to 49 specific gene sequences, the expression of which are correlated with tissue source and tumor type in various cancers. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to determine a cell containing sample as containing tumor cells of a tissue type or from a tissue origin to permit a more accurate identification of the cancer and thus treatment thereof as well as the prognosis of the subject from whom the sample was obtained.

SUMMARY OF THE INVENTION

This invention relates to the use of gene expression measurements to classify or identify tumors in cell containing samples obtained from a subject in a clinical setting, such as in cases of formalin fixed, paraffin embedded (FFPE) samples as well as fresh samples, that have undergone none to little or minimal treatment (such as simply storage at a reduced, non-freezing, temperature), and frozen samples. The invention thus provides the ability to classify tumors in the real-world conditions faced by hospital and other laboratories which conduct testing on clinical FFPE samples. The samples may be of a primary tumor sample or of a tumor that has resulted from a metastasis of another tumor. Alternatively, the sample may be a cytological sample, such as, but not limited to, cells in a blood sample. In some cases of a tumor sample, the tumors may not have undergone classification by traditional pathology techniques, may have been initially classified but confirmation is desired, or have been classified as a “carcinoma of unknown primary” (CUP) or “tumor of unknown origin” (TUO) or “unknown primary tumor”. The need for confirmation is particularly relevant in light of the estimates of 5 to 10% misclassification using standard techniques. Thus the invention may be viewed as providing means for cancer identification, or CID.
In a first aspect of the invention, the classification is performed by use of gene expression profiles, or patterns, of about 5 to 49 expressed sequences. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other markers of gene expression, may be used to determine a cell containing sample as containing tumor cells of a tissue type or from a tissue origin to permit a more accurate identification of the cancer and thus treatment thereof as well as the prognosis of the subject from whom the sample was obtained.
In some embodiments, the invention is used to classify among at least 34 or at least 39 tumor types with significant accuracy in a clinical setting. The invention is based in part on the surprising and unexpected discovery that about 5 to 49 expressed sequences in the human genome are capable of classifying among at least 34, or at least 39, tumor types, as well as subsets of those tumor types, in a meaningful manner. Stated differently, the invention is based in part on the discovery that it is not necessary to use supervised learning to identify gene sequences which are expressed in correlation with different tumor types. Thus the invention is based in part on the recognition that any about 5 to 49 expressed sequences, even a random collection of expressed sequences, has the capability to classify, and so may be used to classify, a cell as being a tumor cell of a tissue or tissue origin. Moreover, relatively few expressed sequences are needed to classify among different tumor types. The ratio of expressed sequences to the number of tumor types that can be classified, based on the expression levels of the sequences, ranges from about 1:2 to about 5:2 or higher as demonstrated herein.
In another aspect, the invention provides for the classifying of a cell containing sample as containing a tumor cell of a tissue type or origin by determining the expression levels of about 5 to 49 transcribed sequences and then classifying the cell containing sample as containing a tumor cell of a plurality (two or more) of tumor types. To classify among 34 to 39 tumor types, and subsets thereof, as few as about any 5 expressed sequences may be used to provide classification in a meaningful manner. It was discovered that the expressed sequences need not be those the expression levels of which are evidently or highly correlated (directly, or indirectly through correlation with another expressed sequence) with any of the tumor types. Thus the invention provides, in yet another embodiment, for the use of the expression levels of genes, the expression levels of which are not strongly correlated with the actual classification of the particular tumor sample, as one of the about 5 to 49 transcribed sequences. All of the genes selected may be such non-correlates, or only a portion of the genes may be non-correlates, typically at least 90%, 85%, 75%, 50% or 25%, as well as portions falling within the ranges created by using any two of the foregoing point examples as endpoints of a range.
The invention is practiced by determining the expression levels of gene sequences where the sequences need not have been selected based on a correlation of their expression levels with the tumor types to be classified. Thus as a non-limiting example, the gene sequences need not be selected based on their correlation values with tumor types or a ranking based on the correlation values. Additionally, the invention may be practice with use of gene expression levels which are not necessarily correlated to one or more other gene expression level(s) used for classification. Thus in some embodiments, the ability for the expression level of one expressed sequence to function in classification is not redundant with (is independent of) the ability of at least one other gene expression level used for classification.
The invention may be applied to identify the origin of a cancer in a patient in a wide variety of cases including, but not limited to, identification of the origin of a cancer in a clinical setting. In some embodiments, the identification is made by classification of a cell containing sample known to contain cancer cells, but the origin of those cells is unknown. In other embodiments, the identification is made by classification of a cell containing sample as containing one or more cancer cells followed by identification of the origin(s) of those cancer cell(s). In further embodiments, the invention is practiced with a sample from a subject with a previous history of cancer, and identification is made by classification of a cell as either being cancer from a previous origin of cancer or a new origin. Additional embodiments include those where multiple cancers found in the same organ or tissue and the invention is used to determine the origin of each cancer, as well as whether the cancers are of the same origin.
The invention is also based in part on the discovery that the expression levels of particular gene sequences can be used to classify among tumor types with greater accuracy than the expression levels of a random group of gene sequences. In one embodiment, the invention provides for the use of expression levels of about 5 to 49 expressed sequences from a first set of 74 expressed sequences in the human genome to classify among at least 39 tumor types with significant accuracy. The invention thus provides for the identification and use of gene expression patterns (or profiles or “signatures”) based on the about 5 to 49 expressed sequences as correlated with at least the 39 tumor types. The invention also provides for the use of about 5 to 49 of the 74 of these expressed sequences to classify among subsets of the 39 tumor types. The ratio of expressed sequences to the number of tumor types, from 2 to 39, that can be classified based on the expression levels of the sequences ranges from about 1:2 to about 5:2 with greater accuracy than the use of a random group of expressed sequences. Depending on the number of tumor types, accuracies ranging from over 75% to 95% may be achieved readily.
In another embodiment, the invention provides for the use of expression levels of about 5 to 49 expressed sequences of a second set of 90 expressed sequences in the human genome to classify among at least 39 tumor types, or subsets thereof, with significant accuracy. 38 of the sequences in this second set are present in the first set of 74 sequences. The expression levels of the about 5 to 49 sequences in the second set may be used in the same manner as described for the first set of 74 sequences. Depending on the number of tumor types, accuracies ranging from about 75% to about 95% may be achieved.
The invention is also based in part upon the discovery that use of about 5 to 49 expressed sequences to classify among 53 tumor types, which include (but is not limited to) the 34 and 39 types described herein, was limited by the number of available samples of some tumor types. As noted hereinbelow, accuracy is linked to the number of available samples of each tumor type such that the ability to classify additional tumor types is readily achieved by the application of increased numbers of each tumor type. Thus while the invention is exemplified by use in classifying among 34 or 39 tumor types as well as subsets of the 34 or 39, about 5 to 49 expressed sequences can also be used to classify among all tumor types with the inclusion of samples of the additional tumor types. Thus the invention also provides for the classification of a tumor as being a type beyond the 34 or 39 types described herein.
The invention is based upon the expression levels of the gene sequences in a set of known tumor cells from different tissues and of different tumor types. These gene expression profiles (of gene sequences in the different known tumor cells/types), whether embodied in nucleic acid expression, protein expression, or other expression formats, may be compared to the expression levels of the same sequences in an unknown tumor sample to identify the sample as containing a tumor of a particular type and/or a particular origin or cell type. The invention provides, such as in a clinical setting, the advantages of a more accurate identification of a cancer and thus the treatment thereof as well as the prognosis, including survival and/or likelihood of cancer recurrence following treatment, of the subject from whom the sample was obtained.
The invention is further based in part on the discovery that use of about 5 to 49 expressed sequences as described herein as capable of classifying among two or more tumor types necessarily and effectively eliminates one or more tumor types from consideration during classification. This reflects the lack of a need to select genes with expression levels that are highly correlated with all tumor types within the range of the classification system. Stated differently, the invention may be practiced with a plurality of genes the expression levels of which are not highly correlated with any of the individual tumor types or multiple types in the group of tumor types being classified. This is in contrast to other approaches based upon the selection and use of highly correlated genes, which likely do not “rule out” other tumor types as opposed to “rule in” a tumor type based on the positive correlation.
The classification of a tumor sample as being one of the possible tumor types described herein to the exclusion of other tumor types is of course made based upon a level of confidence as described below. Where the level of confidence is low, or an increase in the level of confidence is preferred, the classification can simply be made at the level of a particular tissue origin or cell type for the tumor in the sample. Alternatively, and where a tumor sample is not readily classified as a single tumor type, the invention permits the classification of the sample as one of a few possible tumor types described herein. This advantageously provides for the ability to reduce the number of possible tissue types, cell types, and tumor types from which to consider for selection and administration of therapy to the patient from whom the sample was obtained.
The invention thus provides a non-subjective means for the identification of the tissue source and/or tumor type of one or more cancers of an afflicted subject. Where subjective interpretation may have been previously used to determine the tissue source and/or tumor type, as well as the prognosis and/or treatment of the cancer based on that determination, the present invention provides objective gene expression patterns, which may used alone or in combination with subjective criteria to provide a more accurate identification of cancer classification. The invention is particularly advantageously applied to samples of secondary or metastasized tumors, but any cell containing sample (including a primary tumor sample) for which the tissue source and/or tumor type is preferably determined by objective criteria may also be used with the invention. Of course the ultimate determination of class may be made based upon a combination of objective and non-objective (or subjective/partially subjective) criteria.
The invention includes its use as part of the clinical or medical care of a patient. Thus in addition to using an expression profile of genes as described herein to assay a cell containing sample from a subject afflicted with cancer to determine the tissue source and/or tumor type of the cancer, the profile may also be used as part of a method to determine the prognosis of the cancer in the subject. The classification of the tumor/cancer and/or the prognosis may be used to select or determine or alter the therapeutic treatment for said subject. Thus the classification methods of the invention may be directed toward the treatment of disease, which is diagnosed in whole or in part based upon the classification. Given the diagnosis, administration of an appropriate anti-tumor agent or therapy, or the withholding or alternation of an anti-tumor agent or therapy may be used to treat the cancer.
Other clinical methods include those involved in the providing of medical care to a patient based on a classification as described herein. In some embodiments, the methods relate to providing diagnostic services based on expression levels of gene sequences, with or without inclusion of an interpretation of levels for classifying cells of a sample. In some embodiments, the method of providing a diagnostic service of the invention is preceded by a determination of a need for the service. In other embodiments, the method includes acts in the monitoring of the performance of the service as well as acts in the request or receipt of reimbursement for the performance of the service.
The details of one or more embodiments of the invention are set forth in the accompanying drawing and the description below. Other features, objects, and advantages of the invention will be apparent from the drawing and detailed description, and from the claims.

Definitions

As used herein, a “gene” is a polynucleotide that encodes a discrete product, whether RNA or proteinaceous in nature. It is appreciated that more than one polynucleotide may be capable of encoding a discrete product. The term includes alleles and polymorphisms of a gene that encodes the same product, or a functionally associated (including gain, loss, or modulation of function) analog thereof, based upon chromosomal location and ability to recombine during normal mitosis.
A “sequence” or “gene sequence” as used herein is a nucleic acid molecule or polynucleotide composed of a discrete order of nucleotide bases. The term includes the ordering of bases that encodes a discrete product (i.e. “coding region”), whether RNA or proteinaceous in nature. It is appreciated that more than one polynucleotide may be capable of encoding a discrete product. It is also appreciated that alleles and polymorphisms of the human gene sequences may exist and may be used in the practice of the invention to identify the expression level(s) of the gene sequences or an allele or polymorphism thereof. Identification of an allele or polymorphism depends in part upon chromosomal location and ability to recombine during mitosis.
The terms “correlate” or “correlation” or equivalents thereof refer to an association between expression of one or more genes and another event, such as, but not limited to, physiological phenotype or characteristic, such as tumor type.
A “polynucleotide” is a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides. This term refers only to the primary structure of the molecule. Thus, this term includes double- and single-stranded DNA and RNA. It also includes known types of modifications including labels known in the art, methylation, “caps”, substitution of one or more of the naturally occurring nucleotides with an analog, and internucleotide modifications such as uncharged linkages (e.g., phosphorothioates, phosphorodithioates, etc.), as well as unmodified forms of the polynucleotide.
The term “amplify” is used in the broad sense to mean creating an amplification product can be made enzymatically with DNA or RNA polymerases. “Amplification,” as used herein, generally refers to the process of producing multiple copies of a desired sequence, particularly those of a sample. “Multiple copies” mean at least 2 copies. A “copy” does not necessarily mean perfect sequence complementarity or identity to the template sequence. Methods for amplifying mRNA are generally known in the art, and include reverse transcription PCR (RT-PCR) and quantitative PCR (or Q-PCR) or real time PCR. Alternatively, RNA may be directly labeled as the corresponding cDNA by methods known in the art.
By “corresponding”, it is meant that a nucleic acid molecule shares a substantial amount of sequence identity with another nucleic acid molecule. Substantial amount means at least 95%, usually at least 98% and more usually at least 99%, and sequence identity is determined using the BLAST algorithm, as described in Altschul et al. (1990), J. Mol. Biol. 215:403-410 (using the published default setting, i.e. parameters w=4, t=17).
A “microarray” is a linear or two-dimensional or three dimensional (and solid phase) array of discrete regions, each having a defined area, formed on the surface of a solid support such as, but not limited to, glass, plastic, or synthetic membrane. The density of the discrete regions on a microarray is determined by the total numbers of immobilized polynucleotides to be detected on the surface of a single solid phase support, such as of at least about 50/cm², at least about 100/cm², or at least about 500/cm², up to about 1,000/cm²or higher. The arrays may contain less than about 500, about 1000, about 1500, about 2000, about 2500, or about 3000 immobilized polynucleotides in total. As used herein, a DNA microarray is an array of oligonucleotide or polynucleotide probes placed on a chip or other surfaces used to hybridize to amplified or cloned polynucleotides from a sample. Since the position of each particular group of probes in the array is known, the identities of a sample polynucleotides can be determined based on their binding to a particular position in the microarray. As an alternative to the use of a microarray, an array of any size may be used in the practice of the invention, including an arrangement of one or more position of a two-dimensional or three dimensional arrangement in a solid phase to detect expression of a single gene sequence. In some embodiments, a microarray for use with the present invention may be prepared by photolithographic techniques (such as synthesis of nucleic acid probes on the surface from the 3′ end) or by nucleic synthesis followed by deposition on a solid surface.
Because the invention relies upon the identification of gene expression, some embodiments of the invention determine expression by hybridization of mRNA, or an amplified or cloned version thereof, of a sample cell to a polynucleotide that is unique to a particular gene sequence. Polynucleotides of this type contain at least about 16, at least about 18, at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, or at least about 32 consecutive basepairs of a gene sequence that is not found in other gene sequences. The term “about” as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Other embodiments are polynucleotides of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, at least or about 400, at least or about 450, or at least or about 500 consecutive bases of a sequence that is not found in other gene sequences. The term “about” as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value. Longer polynucleotides may of course contain minor mismatches (e.g. via the presence of mutations) which do not affect hybridization to the nucleic acids of a sample. Such polynucleotides may also be referred to as polynucleotide probes that are capable of hybridizing to sequences of the genes, or unique portions thereof, described herein. Such polynucleotides may be labeled to assist in their detection. The sequences may be those of mRNA encoded by the genes, the corresponding cDNA to such mRNAs, and/or amplified versions of such sequences. In some embodiments of the invention, the polynucleotide probes are immobilized on an array, other solid support devices, or in individual spots that localize the probes.
In other embodiments of the invention, all or part of a gene sequence may be amplified and detected by methods such as the polymerase chain reaction (PCR) and variations thereof, such as, but not limited to, quantitative PCR (Q-PCR), reverse transcription PCR (RT-PCR), and real-time PCR (including as a means of measuring the initial amounts of mRNA copies for each sequence in a sample), optionally real-time RT-PCR or real-time Q-PCR. Such methods would utilize one or two primers that are complementary to portions of a gene sequence, where the primers are used to prime nucleic acid synthesis. The newly synthesized nucleic acids are optionally labeled and may be detected directly or by hybridization to a polynucleotide of the invention. The newly synthesized nucleic acids may be contacted with polynucleotides (containing sequences) of the invention under conditions which allow for their hybridization. Additional methods to detect the expression of expressed nucleic acids include RNAse protection assays, including liquid phase hybridizations, and in situ hybridization of cells.
Alternatively, and in further embodiments of the invention, gene expression may be determined by analysis of expressed protein in a cell sample of interest by use of one or more antibodies specific for one or more epitopes of individual gene products (proteins), or proteolytic fragments thereof, in said cell sample or in a bodily fluid of a subject. The cell sample may be one of breast cancer epithelial cells enriched from the blood of a subject, such as by use of labeled antibodies against cell surface markers followed by fluorescence activated cell sorting (FACS). Such antibodies may be labeled to permit their detection after binding to the gene product. Detection methodologies suitable for use in the practice of the invention include, but are not limited to, immunohistochemistry of cell containing samples or tissue, enzyme linked immunosorbent assays (ELISAs) including antibody sandwich assays of cell containing tissues or blood samples, mass spectroscopy, and immuno-PCR.
The terms “label” or “labeled” refer to a composition capable of producing a detectable signal indicative of the presence of the labeled molecule. Suitable labels include radioisotopes, nucleotide chromophores, enzymes, substrates, fluorescent molecules, chemiluminescent moieties, magnetic particles, bioluminescent moieties, and the like. As such, a label is any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means.
The term “support” refers to conventional supports such as beads, particles, dipsticks, fibers, filters, membranes and silane or silicate supports such as glass slides.
“Expression” and “gene expression” include transcription and/or translation of nucleic acid material.
As used herein, the term “comprising” and its cognates are used in their inclusive sense; that is, equivalent to the term “including” and its corresponding cognates.
Conditions that “allow” an event to occur or conditions that are “suitable” for an event to occur, such as hybridization, strand extension, and the like, or “suitable” conditions are conditions that do not prevent such events from occurring. Thus, these conditions permit, enhance, facilitate, and/or are conducive to the event. Such conditions, known in the art and described herein, depend upon, for example, the nature of the nucleotide sequence, temperature, and buffer conditions. These conditions also depend on what event is desired, such as hybridization, cleavage, strand extension or transcription.
Sequence “mutation,” as used herein, refers to any sequence alteration in the sequence of a gene disclosed herein interest in comparison to a reference sequence. A sequence mutation includes single nucleotide changes, or alterations of more than one nucleotide in a sequence, due to mechanisms such as substitution, deletion or insertion. Single nucleotide polymorphism (SNP) is also a sequence mutation as used herein. Because the present invention is based on the relative level of gene expression, mutations in non-coding regions of genes as disclosed herein may also be assayed in the practice of the invention.
“Detection” or “detecting” includes any means of detecting, including direct and indirect determination of the level of gene expression and changes therein.
Unless defined otherwise all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this invention belongs.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a capacity plot for the ability to use the expression levels of subsets of a set of 100 expressed gene sequences to classify among 39 tumor types and subsets thereof. Expression levels of random combinations of 5, 10, 15, 20, 25, 30, 35, 40, 45, and 49 (each sampled 10 times) of the 100 sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to 39 types. A plot of numbers of tumor types (x-axis) versus prediction accuracies (y-axis) for results using from 5 to 49 genes are shown as non-limiting examples. The data from using 5 genes results in a curve closest to the x-axis while the data from using 49 genes results in a curve farthest from the x-axis. Generally, accuracy improves with higher numbers of gene sequences, where from 30 to 49 gene sequences (the three curves farthest from the x-axis) provides about the same level of accuracy.

FIG. 2 shows an alternative presentation of the data used with respect to FIG. 1 . A plot of numbers of gene sequences used, ranging from 5-49 (and in the x-axis), versus prediction accuracies (y-axis) for various representative numbers of tumor types is shown. The plotted lines, from top to bottom, are of the results from 2, 10, 20, 30, and 39 tumor types, respectively.

FIG. 3 provides a further analysis of the ability to use the expression levels of subsets of a set of 100 randomly selected expressed gene sequences to classify among 39 tumor types. The data used with FIGS. 1 and 2 is presented in a plot of the number of tumor types versus the number of gene sequences used at prediction accuracies from 55-70% are shown as non-limiting examples. Generally, accuracy improves with higher numbers of gene sequences.

FIG. 4 shows a capacity plot for the ability to use the expression levels of portions of a first set of 74 expressed gene sequences to classify among 39 tumor types and subsets thereof. Expression levels of random combinations of 5, 10, 15, 20, 25, 30, 35, 40, 45, and 49 (each sampled 10 times) of the 74 sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to 39 types. A plot of numbers of tumor types versus prediction accuracies for results using from 5 to 49 genes are shown as non-limiting examples. The plotted lines, from top to bottom, are of the results from 49, 40, 30, 20, 10, and gene sequences, respectively.

FIG. 5 shows an alternative presentation of the data used with respect to FIG. 4 . A plot of numbers of gene sequences used, ranging from 5-49, versus prediction accuracies for various representative numbers of tumor types is shown. The plotted lines, from top to bottom, are of the results from 2, 10, 20, 30, and 39 tumor types, respectively.

FIG. 6 is analogous to FIG. 3 except with presentation of the data used with FIGS. 4 and 5 .

FIG. 7 shows a capacity plot for the ability to use the expression levels of subsets of a set of 90 expressed gene sequences to classify among 39 tumor types and subsets thereof. Expression levels of random combinations of 5, 10, 15, 20, 25, 30, 35, 40, 45, and 49 (each sampled 10 times) of the 90 sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to 39 types. A plot of numbers of tumor types versus prediction accuracies for results using from 5 to 49 genes are shown as non-limiting examples. The plotted lines, from top to bottom, are of the results from 49, 40, 30, 20, 10, and gene sequences, respectively.

FIG. 8 shows an alternative presentation of the data used with respect to FIG. 7 . A plot of numbers of gene sequences used, ranging from 5-49, versus prediction accuracies for various representative numbers of tumor types is shown. The plotted lines, from top to bottom, are of the results from 2, 10, 20, 30, and 39 tumor types, respectively.

FIG. 9 is analogous to FIGS. 3 and 6 except with presentation of the data used with FIGS. 7 and 8 .

FIGS. 10A-10D show a “tree” that classifies tumor types covered herein as well as additional known tumor types. It was constructed mainly according to “Cancer, Principles and Practice of Oncology, (DeVito, Hellman and Rosenberg), 6^thedition”. Thus beginning with a “tumor of unknown origin” (or “tuo”), the first possibilities are that it is either of a germ cell or non-germ cell origin. If it is the former, then it may be of ovary or testes origin. Within those of testes origin, the tumor may be of seminoma origin or an “other” origin.

If the tumor is of a non-germ cell origin, then it is either of a epithelial or non-epithelial origin. If it is the former, then it is either squamous or non-squamous origin. Squamous origin tumors are of cervix, esophagus, larynx, lung, or skin in origin. Non-squamous origin tumors are of urinary bladder, breast, carcinoid-intestine, cholangiocarcinoma, digestive, kidney, liver, lung, prostate, reproductive system, skin-basal cell, or thyroid-follicular-papillary origin. Among those of digestive origin, the tumors are of small and large bowel, stomach-adenocarcinoma, bile duct, esophagus, gall bladder, and pancreas in origin. The esophagus origin tumors may be of either Barrett's esophagus or adenocarcinoma types. Of the reproductive system origin tumors, they may be of cervix adenocarcinoma type, endometrial tumor, or ovarian origin. Ovarian origin tumors are of the clear, serous, mucinous, and endometroid types.
If the tumor is of non-epithelial origin, then it is of adrenal gland, brain, GIST (gastrointestinal stromal tumor), lymphoma, meningioma, mesothelioma, sarcoma, skin melanoma, or thyroid-medullary origin. Of the lymphomas, they are B cell, Hodgkin's, or T cell type. Of the sarcomas, they are leimyosarcoma, osteosarcoma, soft-tissue sarcoma, soft tissue MFH (malignant fibrous histiocytoma), soft tissue sarcoma synovial, soft tissue Ewing's sarcoma, soft tissue fibrosarcoma, and soft tissue rhabdomyosarcoma types.

DETAILED DESCRIPTION OF MODES OF PRACTICING THE INVENTION

This invention provides methods for the use of gene expression information to classify tumors in a more objective manner than possible with conventional pathology techniques. Thus in a first aspect, the invention provides a method of classifying a cell containing sample as including a tumor cell of (or from) a type of tissue or a tissue origin. The method comprises determining or measuring the expression levels of about five to 49 transcribed sequences from cells in a cell containing sample obtained from a subject, and classifying the sample as containing tumor cells of a type of tissue from a plurality of tumor types based on the expression levels of said sequences. As used herein, “a plurality” refers to the state of two or more.
The classifying is based upon a comparison of the expression levels of the about 5 to 49 transcribed sequences in the cells of the sample to their expression levels in known tumor samples and/or known non-tumor samples. Alternatively, the classifying is based upon a comparison of the expression levels of the about 5 to 49 transcribed sequences to the expression of reference sequences in the same samples, relative to, or based on, the same comparison in known tumor samples and/or known non-tumor samples. Thus as a non-limiting example, the expression levels of the gene sequences may be determined in a set of known tumor samples to provide a database against which the expression levels detected or determined in a cell containing sample from a subject is compared. The expression level(s) of gene sequence(s) in a sample also may be compared to the expression level(s) of said sequence(s) in normal or non-cancerous cells, preferably from the same sample or subject. As described below and in embodiments of the invention utilizing Q-PCR or real time Q-PCR, the expression levels may be compared to expression levels of reference genes in the same sample or a ratio of expression levels may be used.
In practice, the method utilizes a ratio, of transcribed sequences to the number of tumor types classified, ranging from about 1:2 to about 5:2 or higher. Stated differently, the ratio of the number of expression levels needed to the number of tumor types that may be classified based upon those levels, ranges from about 1:2 to about 1:1 to about 3:2 to about 2:1 to about 5:2 or higher. This is reflected by the ability to use as few as about 20 expression levels to classify among 39 tumor types (see FIG. 6 ). Thus, and based on data as shown in FIGS. 1-9 , the invention may be practiced with about 5 to 49 gene sequences within the ratio of genes assessed to tumors classified.
The selection of about 5 to 49 gene sequences to use may be random, or by selection based on various criteria. As one non-limiting example, the gene sequences may be selected based upon unsupervised learning, including clustering techniques. As another non-limiting example, selection may be to reduce or remove redundancy with respect to their ability to classify tumor type. For example, gene sequences are selected based upon the lack of correlation between their expression and the expression of one or more other gene sequences used for classifying. This is accomplished by assessing the expression level of each gene sequence in the expression data set for correlation, across the plurality of samples, with the expression level of each other gene in the data set to produce a correlation matrix of correlation coefficients. These correlation determinations may be performed directly, between expression of each pair of gene sequences, or indirectly, without direct comparison between the expression values of each pair of gene sequences.
A variety of correlation methodologies may be used in the correlation of expression data of individual gene sequences within the data set. Non-limiting examples include parametric and non-parametric methods as well as methodologies based on mutual information and non-linear approaches. Non-limiting examples of parametric approaches include Pearson correlation (or Pearson r, also referred to as linear or product-moment correlation) and cosine correlation. Non-limiting examples of non-parametric methods include Spearman's R (or rank-order) correlation, Kendall's Tau correlation, and the Gamma statistic. Each correlation methodology can be used to determine the level of correlation between the expressions of individual gene sequences in the data set. The correlation of all sequences with all other sequences is most readily considered as a matrix. Using Pearson's correlation as a non-limiting example, the correlation coefficient r in the method is used as the indicator of the level of correlation. When other correlation methods are used, the correlation coefficient analogous to r may be used, along with the recognition of equivalent levels of correlation corresponding to r being at or about 0.25 to being at or about 0.5.
The correlation coefficient may be selected as desired to reduce the number of correlated gene sequences to various numbers. In some embodiments of the invention using r, the selected coefficient value may be of about 0.25 or higher, about 0.3 or higher, about 0.35 or higher, about 0.4 or higher, about 0.45 or higher, or about 0.5 or higher. The selection of a coefficient value means that where expression between gene sequences in the data set is correlated at that value or higher, they are possibly not included in a subset of the invention. Thus in some embodiments, the method comprises excluding or removing (not using for classification) one or more gene sequences that are expressed in correlation, above a desired correlation coefficient, with another gene sequence in the tumor type data set. It is pointed out, however, that there can be situations of gene sequences that are not correlated with any other gene sequences, in which case they are not necessarily removed from use in classification.
Thus the expression levels of gene sequences, where more than about 10%, more than about 20%, more than about 30%, more than about 40%, more than about 50%, more than about 60%, more than about 70%, more than about 80%, or more than about 90% of the levels are not correlated with that of another one of the gene sequences used, may be used in the practice of the invention. Correlation between expression levels may be based upon a value below about 0.9, about 0.8, about 0.7, about 0.6, about 0.5, about 0.4, about 0.3, or about 0.2. The ability to classify among classes with exclusion of the expression levels of some gene sequences is present because expression of the gene sequences in the subset is correlated with expression of the gene sequences excluded from the subset. So no information was lost because information based on the expression of the excluded gene sequences is still represented by sequences retained in the subset. Therefore, expression of the gene sequences of the subset has information content relevant to properties and/or characteristics (or phenotype) of a cell. This has application and relevance to the classification of additional tumor type classes not included as part of the original gene expression data set which can be classified by use of a subset of the invention because based on the redundancy of information between expression of sequences in the subset and sequences expressed in those additional classes. Thus the invention may be used to classify cells as being a tumor type beyond the plurality of known classes used to generate the original gene expression data set.
Selection of gene sequences based upon reducing correlation of expression to a particular tumor type may also be used. This also reflects a discovery of the present invention, based upon the observation that expression levels that were most highly correlated with one or more tumor types was not necessarily of greatest value in classification among different tumor types. This is reflected both by the ability to use randomly selected gene sequences for classification as well as the use of particular sequences, as described herein, which are not expressed with the most significant correlation with one or more tumor types. Thus the invention may be practiced without selection of gene sequences based upon the most significant P values or a ranking based upon correlation of gene expression and one or more tumor types. Thus the invention may be practiced without the use of ranking based methodologies, such as the Kruskal-Wallis H-test.
The gene sequences used in the practice of the invention may include those which have been observed to be expressed in correlation with particular tumor types, such as expression of the estrogen receptor, which has been observed to be expressed in correlation with some breast and ovarian cancers. In some embodiments of the invention, however, the invention is practiced with use of the expression level of at least one gene sequence that has not been previously identified as being associated with any of the tumor types being classified. Thus the invention may be practiced without all of the gene sequences having previously been associated or correlated with expression in the 2 or more (up to 39 or more) tumor types to which a cell containing sample may be classified.
While the invention is described mainly with respect to human subjects, samples from other subjects may also be used. All that is necessary is the ability to assess the expression levels of gene sequences in a plurality of known tumor samples such that the expression levels in an unknown or test sample may be compared. Thus the invention may be applied to samples from any organism for which a plurality of expressed sequences, and a plurality of known tumor samples, are available. One non-limiting example is application of the invention to mouse samples, based upon the availability of the mouse genome to permit detection of expressed murine sequences and the availability of known mouse tumor samples or the ability to obtain known samples. Thus, the invention is contemplated for use with other samples, including those of mammals, primates, and animals used in clinical testing (such as rats, mice, rabbits, dogs, cats, and chimpanzees) as non-limiting examples.
While the invention is readily practiced with the use of cell containing samples, any nucleic acid containing sample which may be assayed for gene expression levels may be used in the practice of the invention. Without limiting the invention, a sample of the invention may be one that is suspected or known to contain tumor cells. Alternatively, a sample of the invention may be a “tumor sample” or “tumor containing sample” or “tumor cell containing sample” of tissue or fluid isolated from an individual suspected of being afflicted with, or at risk of developing, cancer. Non-limiting examples of samples for use with the invention include a clinical sample, such as, but not limited to, a fixed sample, a fresh sample, or a frozen sample. The sample may be an aspirate, a cytological sample (including blood or other bodily fluid), or a tissue specimen, which includes at least some information regarding the in situ context of cells in the specimen, so long as appropriate cells or nucleic acids are available for determination of gene expression levels. The invention is based in part on the discovery that results obtained with frozen tissue sections can be validly applied to the situation with fixed tissue or cell samples and extended to fresh samples.
Non-limiting examples of fixed samples include those that are fixed with formalin or formaldehyde (including FFPE samples), with Boudin's, glutaldehyde, acetone, alcohols, or any other fixative, such as those used to fix cell or tissue samples for immunohistochemistry (IHC). Other examples include fixatives that precipitate cell associated nucleic acids and proteins. Given possible complications in handling frozen tissue specimens, such as the need to maintain its frozen state, the invention may be practiced with non-frozen samples, such as fixed samples, fresh samples, including cells from blood or other bodily fluid or tissue, and minimally treated samples. In some applications of the invention, the sample has not been classified using standard pathology techniques, such as, but not limited to, immunohistochemistry based assays.
In some embodiments of the invention, the sample is classified as containing a tumor cell of a type selected from the following 53, and subsets thereof: Adenocarcinoma of Breast, Adenocarcinoma of Cervix, Adenocarcinoma of Esophagus, Adenocarcinoma of Gall Bladder, Adenocarcinoma of Lung, Adenocarcinoma of Pancreas, Adenocarcinoma of Small-Large Bowel, Adenocarcinoma of Stomach, Astrocytoma, Basal Cell Carcinoma of Skin, Cholangiocarcinoma of Liver, Clear Cell Adenocarcinoma of Ovary, Diffuse Large B-Cell Lymphoma, Embryonal Carcinoma of Testes, Endometrioid Carcinoma of Uterus, Ewings Sarcoma, Follicular Carcinoma of Thyroid, Gastrointestinal Stromal Tumor, Germ Cell Tumor of Ovary, Germ Cell Tumor of Testes, Glioblastoma Multiforme, Hepatocellular Carcinoma of Liver, Hodgkin's Lymphoma, Large Cell Carcinoma of Lung, Leiomyosarcoma, Liposarcoma, Lobular Carcinoma of Breast, Malignant Fibrous Histiocytoma, Medulary Carcinoma of Thyroid, Melanoma, Meningioma, Mesothelioma of Lung, Mucinous Adenocarcinoma of Ovary, Myofibrosarcoma, Neuroendocrine Tumor of Bowel, Oligodendroglioma, Osteosarcoma, Papillary Carcinoma of Thyroid, Pheochromocytoma, Renal Cell Carcinoma of Kidney, Rhabdomyosarcoma, Seminoma of Testes, Serous Adenocarcinoma of Ovary, Small Cell Carcinoma of Lung, Squamous Cell Carcinoma of Cervix, Squamous Cell Carcinoma of Esophagus, Squamous Cell Carcinoma of Larynx, Squamous Cell Carcinoma of Lung, Squamous Cell Carcinoma of Skin, Synovial Sarcoma, T-Cell Lymphoma, and Transitional Cell Carcinoma of Bladder.
In other embodiments of the invention, the sample is classified as containing a tumor cell of a type selected from the following 34, and subsets thereof: adrenal, brain, breast, carcinoid-intestine, cervix (squamous cell), cholangiocarcinoma, endometrium, germ-cell, GIST (gastrointestinal stromal tumor), kidney, leiomyosarcoma, liver, lung (adenocarcinoma, large cell), lung (small cell), lung (squamous), lymphoma (B cell), Lymphoma (Hodgkins), meningioma, mesothelioma, osteosarcoma, ovary (clear cell), ovary (serous cell), pancreas, prostate, skin (basal cell), skin (melanoma), small and large bowel; soft tissue (liposarcoma); soft tissue (MFH or Malignant Fibrous Histiocytoma), soft tissue (Sarcoma-synovial), testis (seminoma), thyroid (follicular-papillary), thyroid (medullary carcinoma), and urinary bladder.
In further embodiments of the invention, the sample is classified as containing a tumor cell of a type selected from the following 39, and subsets thereof: adrenal gland, brain, breast, carcinoid-intestine, cervix-adenocarcinoma, cervix-squamous, endometrium, gall bladder, germ cell-ovary, GIST, kidney, leiomyosarcoma, liver, lung-adenocarcinoma-large cell, lung-small cell, lung-squamous, lymphoma-B cell, lymphoma-Hodgkin's, lymphoma-T cell, meningioma, mesothelioma, osteosarcoma, ovary-clear cell, ovary-serous, pancreas, prostate, skin-basal cell, skin-melanoma, skin-squamous, small and large bowel, soft tissue-liposarcoma, soft tissue-MFH, soft tissue-sarcoma-synovial, stomach-adenocarcinoma, testis-other (or non-seminoma), testis-seminoma, thyroid-follicular-papillary, thyroid-medullary, and urinary bladder.
The methods of the invention may also be applied to classify a cell containing sample as containing a tumor cell of a tumor of a subset of any of the above sets. The size of the subset will usually be small, composed of two, three, four, five, six, seven, eight, nine, or ten of the tumor types described above. Alternatively, the size of the subset may be any integral number up to the full size of the set. Thus embodiments of the invention include classification among 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, or 52 of the above types. In some embodiments, the subset will be composed of tumor types that are of the same tissue or organ type. Alternatively, the subset will be composed of tumor types of different tissues or organs. In some embodiments, the subset will include one or more types selected from adrenal gland, brain, carcinoid-intestine, cervix-adenocarcinoma, cervix-squamous, gall bladder, germ cell-ovary, GIST, leiomyosarcoma, liver, meningioma, osteosarcoma, skin-basal cell, skin-squamous, soft tissue-liposarcoma, soft tissue-MFH, soft tissue-sarcoma-synovial, testis-other (or non-seminoma), testis-seminoma, thyroid-follicular-papillary, and thyroid-medullary.
Classification among subsets of the above tumor types is demonstrated by the results shown in FIGS. 1-9 , where the expression levels of as few as about 5 or more genes sequences can be used to classify among random samples of 2 tumor types among those in the set of 39 listed above. Expression levels of as few as about 20 to 49 can be used to classify among all 39 tumor types with varying degrees of accuracy. The invention may be practiced with the expression levels of about 10 or more, about 15 or more, about 20 or more, about 25 or more, about 30 or more, about 35 or more, about 40 or more, or about 45 or more to 49 transcribed sequences as found in the human “transcriptome” (transcribed portion of the genome). The invention may also be practiced with expression levels of about 10-20 or more, about 20-30 or more, about 30-40 or more, about 40-50 or more, or 49 transcribed sequences. In some embodiments of the invention, the transcribed genes may be randomly picked or include all or some of the specific genes sequences disclosed herein. As demonstrated herein, classification with accuracies of about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, or about 95% or higher can be performed by use of the instant invention.
In other embodiments, the gene expression levels of other gene sequences may be determined along with the above described determinations of expression levels for use in classification. One non-limiting example of this is seen in the case of a microarray based platform to determine gene expression, where the expression of other gene sequences is also measured. Where those other expression levels are not used in classification, they may be considered the results of “excess” transcribed sequences and not critical to the practice of the invention. Alternatively, and where those other expression levels are used in classification, they are within the scope of the invention, where the description of using particular numbers of sequences does not necessarily exclude the use of expression levels of additional sequences. In some embodiments, the invention includes the use of expression level(s) from one or more “excess” gene sequences, such as those which may provide information redundant to one or more other gene sequences used in a method of the invention.
Because classification of a sample as containing cells of one of the above tumor types inherently also classifies the tissue or organ site origin of the sample, the methods of the invention may be applied to classification of a tumor sample as being of a particular tissue or organ site of the patient. This application of the invention is particularly useful in cases where the sample is of a tumor that is the result of metastasis by another tumor. In some embodiments of the invention, the tumor sample is classified as being one of the following 24: Adrenal, Bladder, Bone, Brain, Breast, Cervix, Endometrium, Esophagus, Gall Bladder, Kidney, Larynx, Liver, Lung, Lymph Node, Ovary, Pancreas, Prostate, Skin, Soft Tissue, Small/Large Bowel, Stomach, Testes, Thyroid, and Uterus.
While the invention also provides for classification as one of the above tumor types based upon comparisons to the expression levels of sequences in the 39 tumor types, it is possible that a higher level of confidence in the classification is desired. If an increase in the confidence of the classification is preferred, the classification can be adjusted to identify the tumor sample as being of a particular origin or cell type as shown in FIG. 10 . Thus an increase in confidence can be made in exchange for a decrease in specificity as to tumor type by identification of origin or cell type.
The classification of a cell containing sample as having a tumor cell of one of the 39 tumor types above inherently also classifies the tissue or organ site origin of the sample. For example, the identification of a sample as being cervix-squamous necessarily classifies the tumor as being of cervical origin, squamous cell type (and thus epithelial rather than non-epithelial in origin) as shown in FIG. 10 . It also means that the tumor was necessarily not germ cell in origin. Thus, the methods of the invention may be applied to classification of a tumor sample as being of a particular tissue or organ site of a subject or patient. This application of the invention is particularly useful in cases where the sample is of a tumor that is the result of metastasis by another tumor.
The practice of the invention to classify a cell containing sample as having a tumor cell of one of the above types is by use of an appropriate classification algorithm that utilizes supervised learning to accept 1) the levels of expression of the gene sequences in a plurality of known tumor types as a training set and 2) the levels of expression of the same genes in one or more cells of a sample to classify the sample as having cells of one of the tumor types. Further discussion of this is provided in the Example section herein. The levels of expression may be provided based upon the signals in any format, including nucleic acid expression or protein expression as described herein.
As would be evident to the skilled practitioner, the range of classification is affected by the number of tumor types as well as the number of samples for each tumor type. But given adequate samples of the full range of human tumors as provided herein, the invention is readily applied to the classification of those tumor types as well as additional types.
Non-limiting examples of classification algorithms that may be used in the practice of the invention include supervised learning algorithms, machine learning algorithms, linear discriminant analysis, attribute selection algorithms, and artificial neural networks (ANN). In preferred embodiments of the invention, a distance-based classification algorithm, such as the k-nearest neighbor (KNN) algorithm, or support vector machine (SVM) are used.
The use of KNN is in some embodiments of the invention and is discussed further as a non-limiting representative example. KNN can be used to analyze the expression data of the genes in a “training set” of known tumor samples including all 39 of the tumor types described herein. The training data set can then be compared to the expression data for the same genes in a cell containing sample. The expression levels of the genes in the sample are then compared to the training data set via KNN to identify those tumor samples with the most similar expression patterns. As a non-limiting example, the five “nearest neighbors” may be identified and the tumor types thereof used to classify the unknown tumor sample. Of course other numbers of “nearest neighbors” may be used. Non-limiting examples include less than 5, about 7, about 9, or about 11 or more “nearest neighbors”.
As a hypothetical example, if the five “nearest neighbors” of an unknown sample are four B cell lymphomas and one T cell lymphoma, then the classification of the sample as being of a B cell lymphoma can be made with great accuracy. This has been used with 84% or greater accuracy, such as 90%, as described in the Examples.
The classification ability may be combined with the inherent nature of the classification scheme to provide a means to increase the confidence of tumor classification in certain situations. For example, if the five “nearest neighbors” of a sample are three ovary clear cell and two ovary serous tumors, confidence can be improved by simply treating the tumors as being of ovarian origin and treating the subject or patient (from whom the sample was obtained) accordingly. See FIG. 10 . This is an example of trading off specificity in favor of increased confidence. This provides the added benefit of addressing the possibility that the unknown sample was a mucinous or endometroid tumor. Of course the skilled practitioner is free to treat the tumor as one or both of these two most likely possibilities and proceeding in accordance with that determination.
Because the developmental lineage of tumor cells in certain tumor types (e.g., germ cells) can be complex and involve multiple cell types, FIG. 10 may appear to be oversimplified. However, it serves as a good basis to relate known histopathology and to serve as a “guide tree” for analyzing and relating tumor-associated gene expression signatures.
The inherent nature of the classification scheme also provides a means to increase the confidence of tumor classification in cases wherein the “nearest neighbors” are ambiguous. For example, if the five “nearest neighbors” were one urinary bladder, one breast, one kidney, one liver, and one prostate, the classification can simply be that of a non-squamous cell tumor. Such a determination can be made with significant confidence and the subject or patient from whom the sample was obtained can be treated accordingly. Without being bound by theory, and offered solely to improve the understanding of the invention, the last two examples reflect the similarities in gene expression of cells of a similar cell type and/or tissue origin.
Embodiments of the invention include use of the methods and materials described herein to identify the origin of a cancer from a patient. Thus given a sample containing tumor cells, the tissue origin of the tumor cells is identified by use of the present invention. One non-limiting example is in the case of a subject with an inflamed lymph node containing cancer cells. The cells may be from a tissue or organ that drains into the lymph node or it may be from another tissue source. The present invention may be used to classify the cells as being of a particular tumor or tissue type (or origin) which allows the identification of the source of the cancer cells. In an alternative non-limiting example, the sample (such as that from a lymph node) contains cells, which are first assayed by use of the invention to classify at least one cell as being a tumor cell of a tissue type or origin. This is then used to identify the source of the cancer cells in the sample. Both of these are examples of the advantageous use of the invention to save time, effort, and cost in the use of other cancer diagnostic tests.
In further embodiments, the invention is practiced with a sample from a subject with a previous history of cancer. As a non-limiting example, a cell containing sample (from the lymph node or elsewhere) of the subject may be found to contain cancer cells such that the present invention may be used to determine whether the cells are from the same or a different tissue from that of the previous cancer. This application of the invention may also be used to identify a new primary tumor, such as the case where new cancer cells are found in the liver of a subject who previously had breast cancer. The invention may be used to identify the new cancer cells as being the result of metastasis from the previous breast cancer (or from another tumor type, whether previously identified or not) or as a new primary occurrence of liver cancer. The invention may also be applied to samples of a tissue or organ where multiple cancers are found to determine the origin of each cancer, as well as whether the cancers are of the same origin.
While the invention may be practiced with the use of expression levels of a random group of expressed gene sequences, the invention also provides exemplary gene sequences for use in the practice of the invention. The invention includes a first group of 74 gene sequences from which about 5 to 49 may be used in the practice of the invention. The 5 to 49 gene sequences may be used along with the determination of expression levels of additional sequences so long as the expression levels of gene sequences from the set of 74 are used in classifying. A non-limiting example of such embodiments of the invention is where the expression of from about 5 to 49 of the 74 gene sequences is measured along with the expression levels of a plurality of other sequences, such as by use of a microarray based platform used to perform the invention. Where those other expression levels are not used in classification, they may be considered the results of “excess” transcribed sequences and not critical to the practice of the invention. Alternatively, and where those other expression levels are used in classification, they are within the scope of the invention, where the use of the above described sequences does not necessarily exclude the use of expression levels of additional sequences.
mRNA sequences corresponding to a set of 74 gene sequences for use in the practice of the invention are provided in Example 6 (Sequence Listing) below along with additional identifying information. The listing of the identifying information, including accession numbers and other information, is provided by the following.


>Hs.73995_mRNA_1 gi\|190403\|gb\|M60502.1\|HUMPROFILE Human profilaggrin mRNA,
3′ end polyA=1
>Hs.75236_mRNA_4 gi\|14280328\|gb\|AY033998.1\| Homo sapiens polyA=3
>Hs.299867_mRNA_1 gi\|4758533\|ref\|NM_004496.1\| Homo sapiens hepatocyte
nuclear factor 3, alpha (HNF3A), mRNA polyA=3
>Hs.285401_contig1
AI147926\|AI880620\|AA768316\|AA761543\|AA279147\|AI216016\|AI738663\|N79248\|
AI684489\|AA960845\|AI718599\|AI379138\|N29366\|BF002507\|AW044269\|R34339\|R66326\|
H04648\|R67467\|AI523112\|BF941500 polyA=2 polyA=3
>Hs.182507_mRNA_1 gi\|15431324\|ref\|NM_002283.2\| Homo sapiens keratin, hair,
basic, 5 (KRTHB5), mRNA polyA=3
>Hs.292653_contig1
AI200660\|AW014007\|AI341199\|AI692279\|AI393765\|AI378686\|AI695373\|AW292108\|
T10352\|R44346\|AW470408\|AI380925\|BF938983\|AW003704\|H08077\|F03856\|H08075\|F08895\|
AW468398\|AI865976\|H22568\|AI858374\|AI216499 polyA=2 polyA=3
>Hs.97616_mRNA_3 gi\|12654852\|gb\|BC001270.1\|BC001270 Homo sapiens clone
MGC:5069 IMAGE:3458016 polyA=3
>Hs.123078_mRNA_3 gi\|14328043\|gb\|BC009237.1\|BC009237 Homo sapiens clone
MGC:2216 IMAGE:2989823 polyA=3
>Hs.285508_contig1 AW194680\|BF939744\|BF516467 polyA=1 polyA=1
>Hs.183274_contig1
BF437393\|BF064008\|BF509951\|AW134603\|AI277015\|AI803254\|AA887915\|BF054958\|
AI004413\|AI393911\|AI278517\|AW612644\|AI492162\|AI309226\|AI863671\|AA448864\|AI640165\|
AA479926\|AA461188\|AA780161\|BF591180\|AI918020\|AI758226\|AI291375\|BF001845\|
BF003064\|AI337393\|AI522206\|BE856784\|BF001760\|AI280300 FLAG=1 polyA=2 WARN
polyA=3
>Hs.334841_mRNA_3 gi\|14290606\|gb\|BC009084.1\|BC009084 Homo sapiens clone
MGC:9270 IMAGE:3853674 polyA=3
>Hs.3321_contig1
AI804745\|AI492375\|AA594799\|BE672611\|AA814147\|AA722404\|AW170088\|D11718\|
BG153444\|AI680648\|AA063561\|BE219054\|AI590287\|R55185\|AI479167\|AI796872\|AI018324\|
AI701122\|BE218203\|AA905336\|AI681917\|BI084742\|AI480008\|AI217994\|AI401468
polyA=2 polyA=3
>Hs.306216_singlet1 AW083022 polyA=1 polyA=2
>Hs.99235_contig1 AA456140\|AI167259\|AA450056 polyA=2 polyA=3
>Hs.169172_mRNA_2 gi\|2274961\|emb\|AJ000388.1\|HSCANPX Homo sapiens mRNA for
calpain-like protease CANPX polyA=3
>Hs.351486_mRNA_1 gi\|16549178\|dbj\|AK054605.1\|AK054605 Homo sapiens cDNA
FLJ30043 fis, clone 3NB692001548 polyA=0
>Hs.153504_contig2
BE962007\|AW016349\|AW016358\|AW139144\|AA932969\|AI025620\|AI688744\|AI865632\|
AA854291\|AA932970\|AU156702\|AI634439\|AA152496\|AI539557\|AI123490\|AI613215\|AI318363\|
AW105672\|AA843483\|AI366889\|AW181938\|AI813801\|AI433695\|AA934772\|N72230\|
AI760632\|BE858965\|AW058302\|AI760087\|AI682077\|AA886672\|AI350384\|AW243848\|
AW300574\|BE466359\|AI859529\|AI921588\|BF062899\|BE855597\|BE617708 polyA=2 polyA=3
>Hs.199354_singlet1 AI669760 polyA=1 polyA=2
>Hs.162020_contig1 AW291189\|AA505872 polyA=2 polyA=3
>Hs.30743_mRNA_3 gi\|18201906\|ref\|NM_006115.2\| Homo sapiens preferentially
expressed antigen in melanoma (PRAME), mRNA polyA=3
>Hs.271580_contig1
AI632869\|AW338882\|AW338875\|AW613773\|AI982899\|AW193151\|BE206353\|BE208200\|
AI811548\|AW264021 polyA=2 polyA=3
>Hs.69360_mRNA_2 gi\|14250609\|gb\|BC008764.1\|BC008764 Homo sapiens clone
MGC:1266 IMAGE:3347571 polyA=3
>Hs.30827_contig1 H07885\|N39347\|W85913\|AA583408\|W86449 polyA=2 polyA=3
>Hs.211593_contig2
BF592799\|AI570478\|AA234440\|R40214\|BE501078\|AW593784\|AI184050\|AI284161\|W72149\|
AW780437\|AI247981\|AW241273\|H60824 polyA=2 polyA=3
>Hs.155097_mRNA_1 gi\|15080385\|gb\|BC011949.1\|BC011949 Homo sapiens clone
MGC:9006 IMAGE:3863603 polyA=3
>Hs.5163_mRNA_1 gi\|15990433\|gb\|BC015582.1\|BC015582 Homo sapiens clone
MGC:23280 IMAGE:4637504 polyA=3
>Hs.55150_mRNA_1 gi\|17068414\|gb\|BC017586.1\|BC017586 Homo sapiens clone
MGC:26610 IMAGE:4837506 polyA=3
>Hs.170177_contig3
AI620495\|AW291989\|AA780896\|AA976262\|AI298326\|BF111862\|AW591523\|AI922518\|
AI480280\|BF589437\|AA600354\|AI886238\|AA035599\|H90049\|BF112011\|N52601\|AI570965\|
AI565367\|AW768847\|H90073\|BE504361\|N45292\|AI632075\|AA679729\|AW168052\|AI978827\|
AI968410\|AI669255\|N45300\|AI651256\|AI698970\|AI521256\|AW078614\|AI802070\|AI885947\|
AI342534\|AI653624\|AW243936\|T16586\|R15989\|AI289789\|AI871636\|AI718785\|
AW148847 polyA=2 polyA=3
>Hs.184601_mRNA_5 gi\|4426639\|gb\|AF104032.1\|AF104032 Homo sapiens polyA=2
>Hs.351972_singlet1 AA865917 polyA=2 polyA=3
>Hs.5366_mRNA_2 gi\|15277845\|gb\|BC012926.1\|BC012926 Homo sapiens clone
MGC:16817 IMAGE:3853503 polyA=3
>Hs.18140_contig1
AI685931\|AA410954\|T97707\|AA706873\|AI911572\|AW614616\|AA548520\|AW027764\|
BF511251\|AI914294\|AW151688 polyA=1 polyA=1
>Hs.133196_contig2
BF224381\|BE467992\|AW137689\|AI695045\|AW207361\|BF445141\|AA405473 polyA=2 WARN
polyA=3
>Hs.63325_mRNA_5 gi\|15451939\|ref\|NM_019894.1\| Homo sapiens transmembrane
protease, serine 4 (TMPRSS4), mRNA polyA=3
>Hs.250692_mRNA_2 gi\|184223\|gb\|M95585.1\|HUMHLF Human hepatic leukemia
factor (HLF) mRNA, complete cds polyA=3
>Hs.250726_singlet4 AW298545 polyA=2 polyA=3
>Hs.79217_mRNA_2 gi\|16306657\|gb\|BC001504.1\|BC001504 Homo sapiens clone
MGC:2273 IMAGE:3505512 polyA=3
>Hs.47986_mRNA_1 gi\|13279253\|gb\|BC004331.1\|BC004331 Homo sapiens clone
MGC:10940 IMAGE:3630835 polyA=3
>Hs.94367_mRNA_1 gi\|10440200\|dbj\|AK027147.1\|AK027147 Homo sapiens cDNA:
FLJ23494 fis, clone LNG01885 polyA=3
>Hs.49215_contig1
BI493248\|N66529\|AA452255\|BI492877\|AW196683\|AI963900\|BF478125\|AI421654\|BE466675
polyA=1 polyA=1
>Hs.281587_contig2
R61469\|R15891\|AA007214\|R61471\|AI014624\|N69765\|AW592075\|H09780\|AA709038\|
AI335898\|AI559229\|F09750\|R49594\|H11055\|T72573\|AA935558\|AA988654\|AA826438\|
AI002431\|AI299721 polyA=1 polyA=2
>Hs.79378_mRNA_1 gi\|16306528\|ref\|NM_003914.2\| Homo sapiens cyclin A1
(CCNA1), mRNA polyA=3
>Hs.156469_contig2
AI341378\|AI670817\|AI701687\|AI335022\|AW235883\|AI948598\|AA446356 polyA=2
polyA=3
>Hs.6631_mRNA_1 gi\|7020430\|dbj\|AK000380.1\|AK000380 Homo sapiens cDNA
FLJ20373 fis, clone HEP19740 polyA=3
>Hs.155977_contig1 AI309080\|AI313045 polyA=1 WARN polyA=1
>Hs.95197_mRNA_4 gi\|5817138\|emb\|AL110274.1\|HSM800829 Homo sapiens mRNA;
cDNA DKFZp564I0272 (from clone DKFZp564I0272) polyA=3
>Hs.48956_contig1 N64339\|AI569513\|AI694073 polyA=1 polyA=1
>Hs.118825_mRNA_10 gi\|1495484\|emb\|X96757.1\|HSSAPKK3 H.sapiens mRNA for MAP
kinase kinase polyA=3
>Hs.135118_contig3
AI683181\|AI082848\|AW770198\|AI333188\|AI873435\|AW169942\|AI806302\|AW340718\|
BF196955\|AA909720 polyA=1 polyA=2
>Hs.171857_mRNA_1 gi\|13161080\|gb\|AF332224.1\|AF332224 Homo sapiens testis
protein mRNA, partial cds polyA=3
>Hs.18910_mRNA_3 gi\|12804464\|gb\|BC001639.1\|BC001639 Homo sapiens clone
MGC:1944 IMAGE:2959372 polyA=3
>Hs.194774_mRNA_1 gi\|16306633\|gb\|BC001492.1\|BC001492 Homo sapiens clone
MGC:1774 IMAGE:3510004 polyA=3
>Hs.127428_mRNA_2 gi\|16306818\|gb\|BC006537.1\|BC006537 Homo sapiens clone
MGC:1934 IMAGE:2987903 polyA=3
>Hs.126852_contig1
AI802118\|BF197404\|BF224434\|AA931964\|AW236083\|AI253119\|AW614335\|AI671372\|
AI793240\|AW006851\|AI953604\|AI640505\|AI633982\|AW195809\|AI493069\|AW058576\|
AW293622 polyA=2 polyA=3
>Hs.28149_mRNA_1 gi\|14714936\|gb\|BC010626.1\|BC010626 Homo sapiens clone
MGC:17687 IMAGE:3865868 polyA=3
>Hs.35453_mRNA_3 gi\|7018494\|emb\|AL157475.1\|HSM802461 Homo sapiens mRNA;
cDNA DKFZp761G151 (from clone DKFZp761G151); partial cds polyA=3
>Hs. 180570_contig1 R08175\|AA707224\|AA699986\|R11209\|W89099\|T98002\|AA494546
polyA=2 polyA=3
>Hs.196270_mRNA_1 gi\|11545416\|gb\|AF283645.1\|AF283645 Homo sapiens
chromosome 8 map 8q21 polyA=3
>Hs.9030_mRNA_3 gi\|12652600\|gb\|BC000045.1\|BC000045 Homo sapiens clone
MGC:2032 IMAGE:3504527 polyA=3
>Hs.1282_mRNA_3 gi\|4559405\|ref\|NM_000065.1\| Homo sapiens complement
component 6 (C6), mRNA polyA=1
>Hs. 268562_mRNA_2 gi\|15341874\|gb\|BC013117.1\|BC013117 Homo sapiens clone
MGC:8711 IMAGE:3882749 polyA=3
>Hs.151301_mRNA_3 gi\|16041747\|gb\|BC015754.1\|BC015754 Homo sapiens clone
MGC:23085 IMAGE:4862492 polyA=3
>Hs.111_contig1 AA946776\|AW242338\|H24274\|AI078616 polyA=1 polyA=2
>Hs.150753_contig1 AI123582\|AI288234 polyA=0 polyA=0
>Hs.82109_mRNA_1 gi\|14250611\|gb\|BC008765.1\|BC008765 Homo sapiens clone
MGC:1622 IMAGE:3347793 polyA=3
>Hs.44276_mRNA_2 gi\|12654896\|gb\|BC001293.1\|BC001293 Homo sapiens clone
MGC:5259 IMAGE:3458115 polyA=3
>Hs .2142_mRNA_4 gi\|13325274\|gb\|BC004453.1\|BC004453 Homo sapiens clone
MGC:4303 IMAGE:2819400 polyA=3
>Hs.180908_contig1 AA846824\|AW611680\|AA846182\|AA846342\|AA846360 polyA=2
polyA=3
>Hs.89436_mRNA_1 gi\|16507959\|ref\|NM_004063.2\| Homo sapiens cadherin 17, LI
cadherin (liver-intestine) (CDH17), mRNA polyA=1
>Hs.151544_mRNA_8 gi\|3153107\|emb\|AL023657.1\|HSDSHP Homo sapiens SH2D1A
cDNA, formerly known as DSHP polyA=3
>Hs.1657_contig4
AW473119\|AA164586\|AI540656\|AI758480\|AI810941\|AI978964\|AI675862\|AI784397\|
AW591562\|AW514102\|AI888116\|AI983175\|AI634735\|AI669577\|AI202659\|AI910598\|AI961352\|
AI565481\|AI886254\|AI538838\|AA291749\|AW571455\|AI370308\|AI274727\|AW473925\|
AW514787\|AI273871\|AW470552\|AI524356\|AI888281\|AW089672\|AI952766\|AW440601\|
AI654044\|AW438839\|AI972926 polyA=2 polyA=3
>Hs.35984_mRNA_1 gi\|6049161\|gb\|AF133587.1\|AF133587 Homo sapiens chromosome
22 map 22q11.2 polyA=3
>Hs.334534_mRNA_2 gi\|17389403\|gb\|BC017742.1\|BC017742 Homo sapiens, clone
IMAGE:4391536, mRNA polyA=3
>Hs.60162_mRNA_1 gi\|10437644\|dbj\|AK025181.1\|AK025181 Homo sapiens cDNA:
FLJ21528 fis, clone COL05977 polyA=3

As would be understood by the skilled person, detection of expression of any of the above identified sequences, or the sequences provided in Example 6 (Sequence Listing) below may be performed by the detection of expression of any appropriate portion or fragment of these sequences. Preferably, the portions are sufficiently large to contain unique sequences relative to other sequences expressed in a cell containing sample. Moreover, the skilled person would recognize that the disclosed sequences represent one strand of a double stranded molecule and that either strand may be detected as an indicator of expression of the disclosed sequences. This follows because the disclosed sequences are expressed as RNA molecules in cells which are preferably converted to cDNA molecules for ease of manipulation and detection. The resultant cDNA molecules may have the sequences of the expressed RNA as well as those of the complementary strand thereto. Thus either the RNA sequence strand or the complementary strand may be detected. Of course is it also possible to detect the expressed RNA without conversion to cDNA.
In some embodiments of the invention, the expression levels of gene sequences is measured by detection of expressed sequences in a cell containing sample as hybridizing to the following oligonucleotides, which correspond to the above sequences as indicated by the accession numbers provided.

	>AF133587
	CCCGGATCGCCATCAGTGTCATCGAGTTCA

	AACCCTGAGCCCTTCATTCACCTCTGTGAG

	>BC017742
	TGCCCTTGCTCTGTGTCATCTCAGTCATTT

	GACTTAGAAAGTGCCCTTCAAAAGGACCCT

	>BF437393
	GGAGGGAGGGCTAATTATATATTTTGTTGT

	TCCTCTATACTTTGTTCTGTTGTCTGCGCC

	>AI620495
	CAGTTTGGATTGTATAATAACGCCAAGCCC

	AGTTGTAGTCGTTTGAGTGCAGTAATGAAA

	>AK000380
	AAATCAGAGTAACCCTTTCTGTATTGAGTG

	CAGTGTTTTTTACTCTTTTCTCATGCACAT

	>BC009237
	TGCCTGGCACAAAGAAGGAAGAATATAAAT

	GATAGTTCGACTCGTCTGTGGAAGAACTTA

	>BC008765
	AGTCTTTTGCTTTTGGCAAAACTCTACTTA

	ATCCAATGGGTTTTTCCCTGTACAGTAGAT

	>BC001504
	GGTTACTGTGGGTGGAATAGTGGAGGCCTT

	CAACTGATTAGACAAGGCCCGCCCACATCT

	>NM_019894
	TAAAATGCACTGCCCTACTGTTGGTATGAC

	TACCGTTACCTACTGTTGTCATTGTTATTA

	>BF224381
	TTCTCTTTTGGGGGCAAACACTATGTCCTT

	TTCTTTTTCTAGATACAGTTAATTCCTGGA

	>AL157475
	AAGACCCACACCCTGTAGCAATACCAAGTG

	CTATTACATAATCAATGGACGATTTATACT

	>AY033998
	AGTGTTGCAAGTTTCCTTTAAAACCAACAA

	AGCCCACAAGTCCTGAATTTCCCATTCTTA

	>H07885
	GTCACTGTCATAGCAGCTGTGATTTCACAA

	GGAAGGGTGCTGCAGGGGGACCTGGTTGAT

	>NM_004496
	TTTCATCCAGTGTTATGCACTTTCCACAGT

	TGGTGTTAGTATAGCCAGAGGGTTTCATTA

	>AA846824
	GGGAAGTAGGGATTATTCGTTTAAATTCAA

	TCGCGAGCACCAAGTCGGACTGGCCGGGGA

	>BC017586
	GGGACCAGGCCCTGGGACAGCCATGTGGCT

	CCAAATGACTAAATGTCAGCTCAAAAACCA

	>AA456140
	TCCGTTTATGGAGGCAATTCCATATCCTTT

	CTTGAACGCACATTCAGCTTACCCCAGAGA

	>NM_002283
	AGAGTTAAGCCACTTCCTGGGTCTCCTTCT

	TATGACTGTCTATGGGTGCATTGCCTTCTG

	>AL023657

	GTGGCCTGAGTAATGCATTATGGGTGGTTT

	ACCATTTCTTGAGGTAAAAGCATCACATGA

	>BC001639
	ACACATGCATGTGTCTGTGTATGTGTGAAT

	GTGAGAGAGACACAGCCCTCCTTTCAGAAG

	>BC015754
	TCTGTAACTGCACAACCCTGGGGTTTGCTG

	CAGAGCTATTTCTTTCCATGTAAAGTAGTG

	>AF332224
	AAACACTCTTTCCGACTCCAGAGGAGAAGC

	TGGCAGCTCTCTGTAAGAAATATGCTGATC

	>BC001270
	GCTTCCTCTATCGCCCAATGCAAAATCGAT

	GAAATGGGGAGTTCTCTGGGCCAGGCCACA

	>AI147926
	GTAGAATCCTCTGTTCATAATGAACAAGAT

	GAACCAATGTGGATTAGAAAGAAGTCCGAG

	>AW298545
	CTGTTTTAAAACTGAATGGCACGAAATTGT

	TTTCCTCAACTCGGAGATTCCTGTATGGAG

	>AI802118
	AATAAATAGTAGCTCTGCTGATGATGACGT

	TGATAACCAAACTGTTCTGTGGTCTTAAGT

	>AI683181
	CAAACAGCCCGGTCTTGATGCAGGAGAGTC

	TGGAAAAGGAAGAAAATGGTTTCAGTTTCA

	>M95585
	AACATGGACCATCCAAATTTATGGCCGTAT

	CAAATGGTAGCTGAAAAAACTATATTTGAG

	>AK027147
	TTGTAATCATGCCAATTCCAGATCAATAAC

	TGCATGTCTGTTCTTTGGTAGAAATAGCTT

	>AW291189
	AAAGATTATTAACCCAAATCACCTTTCTTG

	CTTACTCCAGATGCCTCAGCCTCTGATATA

	>AI632869
	GACTTCCTTTAGGATCTCAGGCTTCTGCAG

	TTCTCATGACTCCTACTTTTCATCCTAGTC

	>BC006537
	CTGTATATTTTGCAATAGTTACCTCAAGGC

	CTACTGACCAAATTGTTGTGTTGAGATGAT

	>R61469
	TGTTCAAACAGACTTTAACCTCTGCATCAT

	ACTTAACCCTGCGACATGCGTACAGTATGC

	>BC009084
	TGAGTCATATACATTTACTGACCACTGTTG

	CTTGTTGCTCACTGTGCTGCTTTTCCATGA

	>N64339
	CTGAAATGTGGATGTGATTGCCTCAATAAA

	GCTCGTCCCCATTGCTTAAGCCTTCAAAAA

	>AI200660
	ATCAAGAAAACCTAATCTTCTGACTCCCAG

	GCCAGGATGTTTTATTTCTCACATCATGTC

	>AK054605
	TTCATTTCCAAACATCATCTTTAAGACTCC

	AAGGATTTTTCCAGGCACAGTGGCTCATAC

	>NM_006115
	AGTTAGAAATAGAATCTGAATTTCTAAAGG

	GAGATTCTGGCTTGGGAAGTACATGTAGGA

	>X96757
	CAATTTTCTTTTTACTCCCCCTCTTAAGGG

	GGCCTTGGAATCTATAGTATAGAATGAACT

	>AI804745
	GGGTGGAGTTTCAGTGAGAATAAACGTGTC

	TGCCTTTGTGTGTGTGTATATATACAGAGA

	>AJ000388
	CTCGCTCATTTTTTACCATGTTTTCCAGTC

	TGTTTAACTTCTGCAGTGCCTTCACTACAC

	>BC008764
	CTTTGGGCCGAGCACTGAATGTCTTGTACT

	TTAAAAAAATGTTTCTGAGACCTCTTTCTA

	>AI309080
	CTGGACCCTTGGAGCAGTGTTGTGTGAACT

	TGCCTAGAACTCTGCCTTCTCCGTTGTCAA

	>AA865917
	CCACCTCCTTCGACCTCCACTGCGCCCCAC

	CTCCCTGCCTGTGTGTGTTATTTCAAAGGA

	>AA946776
	TCTGGCTGGTGGCCTGCGCGAGGGTGCAGT

	CTTACTTAAAAGACTTTCAGTTAATTCTCA

	>AF104032
	AGATGCTGTCGGCACCATGTTTATTTATTT

	CCAGTGGTCATGCTCAGCCTTGCTGCTCTG

	>AW194680
	TCCTTCCTCTTCGGTGAATGCAGGTTATTT

	AAACTTTGGGAAATGTACTTTTAGTCTGTC

	>BC001293
	GTCCTGTCCCTGTCTGGGAGTTGTGTTATT

	TAAAGATATTCTGTATGTTGTATCTTTTGC

	>BE962007
	ATTATATTTCAGGTGTCCTGAACAGGTCAC

	TAGACTCTACATTGGGCAGCCTTTAAATAT

	>BI493248
	AGGAATGGTACTACCGTTCCAGATTTTCTG

	TAATTGCTTCTGCAAAGTAATAGGCTTCTT

	>AF283645
	CTGTACCCAAAGGATGCCAGAATACTAGTA

	TTTTTATTTATCGTAAACATCCACGAGTGC

	>AI669760
	ATTGCCCCCCTAACCAATCATGCAAACTTT

	TCCCCCCCTGGGGTAATTCACCAGTTAAAA

	>BC001492
	CCCACAGTATTTAATGCCCTGTCAGTCCCT

	TCTAGTCTGACTCAATGGTAACTTGCTGTA

	>BC004453
	AAAACCAACTCTCTACTACACAGGCCTGAT

	AACTCTGTACGAGGCTTCTCTAACCCCTAG

	>BC010626
	CTCAGACTGGGCTCCACACTCTTGGGCTTC

	AGTCTGCCCATCTGCTGAATGGAGACAGCA

	>BC013117
	CCTAATGGGGATTCCTCTGGTTGTTCACTG

	CCAAAACTGTGGCATTTTCATTACAGGAGA

	>BC011949
	CACTCACAATTGTTGACTAAAATGCTGCCT

	TTAAAACATAGGAAAGTAGAATGGTTGAGT

	>AW083022
	CTTTGAAGGGCTGCTGCACATTGTTGAATC

	CATCGACCTTTAGCTGCAATGGGATCTCTA

	>R08175
	TGCCTCATCGATATTATAGGGGTCCATCAC

	AACCCAACTGTGTGGCCGGATCCTGAGTCT

	>NM_000065
	AAAACAGACAAAAGCCTTTGCCTTCATGAA

	GCATACATTCATTCAGGGGTAGACACACAA

	>AK025181
	TAACAAACAAAGGCAGTAGCTCATCACTTG

	GGTAGCAGGTACCCATTTTAGGACCCTACA

	>NM_003914
	ATATCAGAAGTGCCAATAATCGTCATAGGC

	TTCTGCACGTTGGATCAACTAATGTTGTTT

	>AI123582
	ATCATAGCCCAACCATGTGAGAAGAAGGAG

	AAGGCCCCCCTTTCTTCATTAATCTGAAAA

	>BC004331
	GCAGACCATTCTATCATACCTGGCAGGGCT

	TCTGTTTTATTTTGTAGGCTGGATGCTACC

	>AI341378
	ACTACAAGCCTCTTGTTTTTCACCAAAACC

	CTACATCTCAGGCTTACTAATTTTTGTGAT

	>NM_004063
	GCCATGCATACATGCTGCGCATGTTTTCTT

	CATTCGTATGTTAGTAAAGTTTTGGTTATT

	>BC012926
	CACCTATTTATTTTACCTCTTTCCCAAACC

	TGGAGCATTTATGCCTAGGCTTGTCAAGAA
	>AL110274

	GTGGACATAGCCACTAACCAACTAGTTACC

	TTTGGACTGCAACAAAAAATGTGAAAATGA

	>AW473119
	ACTTGTAAACCTCTTTTGCACTTTGAAAAA

	GAATCCAGCGGGATGCTCGAGCACCTGTAA

	>AI685931
	AATTCTCTATAAACGGTTCACCAGCAAACC

	ACCAATACATTCCATTGTTTGCCTAGAGAG

	>BF592799
	AATGGCCCATGCATGCTGTTTGCAGCAGTC

	AATTGAGTTGAATTAGAATTCCAACCATAC

	>BC000045
	GAGCTCAGTACTTGCCCTGTGAAAATCCCA

	GAAGCCCCCGCTGTCAATGTTCCCCATCCA

	>BC015582
	ATGAAGCGGAATTAGGCTCCCGAGCTAAGG

	GACTCGCCTAGGGTCTCACAGTGAGTAGGA

	>M60502
	AGTGGCTATATCAACATCAGGGCTAGCACA

	TCTTTCTCTATTATCCTTCTATTGGAATTC

The invention also provides a second group of 90 gene sequences from which about 5 to 49 may be used in the practice of the invention. The about 5 to 49 gene sequences may be used along with the determination of expression levels of additional sequences so long as the expression levels of gene sequences from the set of 90 are used in classifying. A non-limiting example of such embodiments of the invention is where the expression of about 5 to 49 of the 90 gene sequences is measured along with the expression levels of a plurality of other sequences, such as by use of a microarray based platform used to perform the invention. Where those other expression levels are not used in classification, they may be considered the results of “excess” transcribed sequences and not critical to the practice of the invention. Alternatively, and where those other expression levels are used in classification, they are within the scope of the invention, where the use of the above described sequences does not necessarily exclude the use of expression levels of additional sequences.
38 members of the set of 90 are included in the first set of 74 described above. The accession numbers of these members in common between the two sets are AA456140, AA846824, AA946776, AF332224, AI620495, AI632869, AI802118, AI804745, AJ000388, AK025181, AK027147, AL157475, AW194680, AW291189, AW298545, AW473119, BC000045, BC001293, BC001504, BC004453, BC006537, BC008765, BC009084, BC011949, BC012926, BC013117, BC015754, BE962007, BF224381, BF437393, BI493248, M60502, NM_000065, NM_003914, NM_004063, NM_004496, NM_006115, and R61469. mRNA sequences corresponding to members of the set of 90 that are not present in the set of 74 gene sequences are also provided in Example 6 (Sequence Listing) along with additional identifying information. The listing of the identifying information for these 52 unique members by accession numbers, as well as corresponding oligonucleotide sequences which may be used in the practice of the invention, is provided by the following.

	>R15881
	ACTTCTGGTGATGATAAAAATGGTTTTATC

	ACCCAGATGTGAAAGAAGCTGCCTGTTTAC

	>AI041545
	GTGGTTCTGTAAAAACGCAGAGGAAAAGAG

	CCAGAAGGTTTCTGTTTAATGCATCTTGCC

	>NM_024423
	TTTATAAGGAAGCAGCTGTCTAAAATGCAG

	TGGGGTTTGTTTTGCAATGTTTTAAACAGA

	>AB038160
	CTTATGAAGCTGGCCGGGCCACTCACGTTC

	AATGGTACATCTGGGTCTCTATGTGGTTCT

	>AK026790
	GTGAGCCAGCATTTCCCATAGCTAACCCTA

	TTCTCTTAGTCTTTCAAAATGTAGAATGGG

	>BC012727
	CTTTACACCTGATAAAATATTTTGCGAAGA

	GAGGTGTTCTTTTTCCTTACTGGTGCTGAA

	>BC016451
	GCATACATCTCATCCACAGGGGAAGATAAA

	GATGGTCACACAAACAGTTTCCATAAAGAT

	>H09748
	TGAGTTCAGCATGTGTCTGTCCATTTCATT

	TGTACGCTTGTTCAAAACCAAGTTTGTTCT

	>NM_006142
	AAGACCGAGACTGAGGGAAAGCATGTCTGC

	TGGGTGTGACCATGTTTCCTCTCAATAAAG

	>AF191770
	GGCATCTGGCCCCTGGTAGCCAGCTCTCCA

	GAATTACTTGTAGGTAATTCCTCTCTTCAT

	>NM_006378
	TGGATGTTTGTGCGCGTGTGTGGACAGTCT

	TATCTTCCAGCATGATAGGATTTGACCATT

	>BC006819
	TCCTGGCAGAGCCATGGTCCCAGGCTTCCC

	AAAAGTGTTTGTGGCAATTATTCCCCTAGG

	>X79676
	TTTGATGATAGCAGACATTGTTACAAGGAC

	ATGGTGAGTCTATTTTTAATGCACCAATCT

	>BC006811
	TTCTTCCAGTTGCACTATTCTGAGGGAAAA

	TCTGACACCTAAGAAATTTACTGTGAAAAA

	>NM_000198
	GAACAATTGTGGTCTCTCTTAACTTGAGGT

	TCTCTTTTGACTAATAGAGCTCCATTTCCC

	>AF301598
	GTTAAGTGTGGCCAAGCGCACGGCGGCAAG

	TTTTCAAGCACTGAGTTTCTATTCCAAGAT

	>NM_002847
	CGGCCTACTGAGCGGACAGAATGATGCCAA

	AATATTGCTTATGTCTCTACATGGTATTGT

	>NM_004062
	CAGGGTGTTTGCCCAATAATAAAGCCCCAG

	AGAACTGGGCTGGGCCCTATGGGATTGGTA

	>AW118445
	TGTACAGTTTGGTTGTTGCTGTAAATATGG

	TAGCGTTTTGTTGTTGTTGTTTTTTCATGC

	>BC002551
	TACCAAACTGGGACTCACAGCTTTATTGGG

	CTTTCTTTGTGTCTTGTGTGTTTCTTTTAT

	>AA765597
	CATTGAGGTTTGGATGGTGGCAGGTAAAAC

	AGAAAGGCAAGATGTCATCTGACATTAGGC

	>AL137761
	AGTTCAGCACTGTGGTTATCATTGGTGATG

	CCAGAAAACATTAGTAGACTTAGACAATTG

	>X78202
	TAAAATTTCTTGATTGTGACTATGTGGTCA

	TATGCCCGTGTTTGTCACTTACAAAAATGT

	>AK025615
	AGCCATCTGGTGTGAAGAACTCTATATTTG

	TATGTTGAGAGGGCATGGAATAATTGTATT

	>BC001665
	CTTATTGTCACTGGTTAAGAACTTGGCGAG

	ATTGAAGGGCTTTTGTTATTGTTGTTGGAT

	>AI985118
	CTTTCTAGTGAGCTAACCGTAACAGAGAGC

	CTACAGGATACACGTGAGATAATGTCACGT

	>AL039118
	TTGTCTTAAAATTTCTTGATTGTGATACTG

	TGGTCATATGCCCGTGTTTGTCACTTACAA

	>AA782845
	CCTGGGGGAAAGGGGCATTCATGACCTGAA

	CTTTTTAGCAAATTATTATTCTCAGTTTCC

	>BC016340
	TTCATTAACAGTACTAAGTGGAAGGGATCT

	GCAGATTCCAAATTGGAATAAGCTCTATCA

	>AA745593
	CCAATGCAGAAGAGTATTAAGAAAGATGCT

	CAAGTCCCATGGCACAGAGCAAGGCGGGCA

	>NM_004967
	CAAGGCTACGATGGCTATGATGGTCAGAAT

	TACTACCACCACCAGTGAAGCTCCAGCCTG

	>BF510316
	AGCTCACAGCTGGACAGGTGTTGTATATAG

	AGTGGAATCTCTTGGATGCAGCTTCAAGAA

	>AA993639
	TCCAAAGTAGAAAGGGTTCTTTTAGAAAAC

	TTGAAGAATGTGCCTCCTCTTAGCATCTGT

	>AV656862
	GATGCATTTTTCAGTCCCTTTTCAGAGCAA

	ATGCTTTTGCAATGGTAGTAATGTTTAGTT

	>X69699
	CCTGTGGGGCTTCTCTCCTTGATGCTTCTT

	TCTTTTTTTAAAGACAACCTGCCATTACCA

	>BC013282
	TTGCACTAAGTCATGCTGTTTCCTCAAAGA

	AGCTTTGTTTTTTGTTAACGTATTACTCAG

	>AI457360
	CTGGATCCCAGGCCCTGGCACCCCTCAGGA

	AATACAAGAAAAAGAATATTCACATCTGTT

	>AW445220
	TTAGAGGGGCCACCTATCAACTCATCAGTG

	TTCAAAGAATATGCTGGGAGCATGGGTGAG

	>AF038191
	GGCCCATTTATGTCCCTCATGTCTCTAGAT

	TTTCTCGTCACCCAGCCTCAAAAATATATG

	>X05615
	TCCCCAAAAACCTCACCCGAGGCTGCCCAC

	TATGGTCATCTTTTTCTCTAAAATAGTTAC

	>BC005364
	GAAATTCCTCACACCTTGCACCTTCCCTAC

	TTTTCTGAATTGCTATGACTACTCCTTGTT

	>AK025701
	TGTCTGTCCACCACGAGATGGGAGGAGGAG

	AAAAAGCGGTACGATGCCTTCCTGACCTCA

	>BF446419
	GTCTTATCTCTCAGGGGGGGTTTAAGTGCC

	GTTTGCAATAATGTCGTCTTATTTATTTAG

	>AK025470
	CCGAGTAGTATGGGTCTCTGTGTGAGAAAC

	CAGGAGATATTTTCATCTTGTTCGGAAATA

	>BE552004
	TTGTGCAAAAGTCCCACAACCTTTCTGGAT

	TGATAGTTTGTGGTGAAATAAACAATTTTA

	>H05388
	TCCAGTATTCTGCAGGGCCAGTCAGTTGTA

	CAGAAGTTGGAATATTCTGTTCCAGAATTA

	>NM_033229
	GTCTCGAACAGCGGTTGTTTTTACTTTATT

	TATCTTAGGCCCTCAGCTCCCTGACGTCCT

	>BC010437
	AGTGAATCTTTTCCTCTTGGTAGCATCAAC

	ACTGGGGATAAATCAGAACCATTCTGTGGA

	>AI952953
	TGAGAGCCCAGAACAAGAAGGAGCAGAAGG

	GCACTTTGACCTTCATTATTATGAAAATCA

	>R45389
	GGAAGAACTGATGCTTGCTGCTAACTAAAG

	TTTTGGATGTATCGATTTAGAGAACCAATT

	>NM_001337
	GAATGAGAGAATAAGTCATGTTCCTTCAAG

	ATCATGTACCCCAATTTACTTGCCATTACT

	>AI499593
	TACGGAAAGGAAACAGGTTATACTCTTAGA

	TTTAAAAAGTGAAAGAAACTGCAGGCGCCT

In some embodiments of the invention, the expression levels of gene sequences is measured by detection of expressed sequences in a cell containing sample as hybridizing to the above oligonucleotides, which correspond to sequences in Example 6 (Sequence Listing) as indicated by the accession numbers provided.
In additional embodiments, the invention provides for use of any number of the gene sequences of the set of 74 or the set of 90 in the methods of the invention. Thus anywhere from 1 to all of the 49 gene sequences used in the invention may be from either or both of the above sets. So from one, two, three, four, or five, or more of the about 5 to 49 sequences may be from the set of 74 or the set of 90. Similarly, and where from 10 to 49 sequences are used, six, seven, eight, nine, or ten of the sequences may be from one of these sets.
As used herein, a “tumor sample” or “tumor containing sample” or “tumor cell containing sample” or variations thereof, refer to cell containing samples of tissue or fluid isolated from an individual suspected of being afflicted with, or at risk of developing, cancer. The samples may contain tumor cells which may be isolated by known methods or other appropriate methods as deemed desirable by the skilled practitioner. These include, but are not limited to, microdissection, laser capture microdissection (LCM), or laser microdissection (LMD) before use in the instant invention. Alternatively, undissected cells within a “section” of tissue may be used. Non-limiting examples of such samples include primary isolates (in contrast to cultured cells) and may be collected by any non-invasive or minimally invasive means, including, but not limited to, ductal lavage, fine needle aspiration, needle biopsy, the devices and methods described in U.S. Pat. No. 6,328,709, or any other suitable means recognized in the art. Alternatively, the sample may be collected by an invasive method, including, but not limited to, surgical biopsy.
The detection and measurement of transcribed sequences may be accomplished by a variety of means known in the art or as deemed appropriate by the skilled practitioner. Essentially, any assay method may be used as long as the assay reflects, quantitatively or qualitatively, expression of the transcribed sequence being detected.
The ability to classify tumor samples is provided by the recognition of the relevance of the level of expression of the gene sequences (whether randomly selected or specific) and not by the form of the assay used to determine the actual level of expression. An assay of the invention may utilize any identifying feature of a individual gene sequence as disclosed herein as long as the assay reflects, quantitatively or qualitatively, expression of the gene in the “transcriptome” (the transcribed fraction of genes in a genome) or the “proteome” (the translated fraction of expressed genes in a genome). Additional assays include those based on the detection of polypeptide fragments of the relevant member or members of the proteome. Non-limiting examples of the latter include detection of proteolytic fragments found in a biological fluid, such as blood or serum. Identifying features include, but are not limited to, unique nucleic acid sequences used to encode (DNA), or express (RNA), said gene or epitopes specific to, or activities of, a protein encoded by a gene sequence.
Additional means include detection of nucleic acid amplification as indicative of increased expression levels and nucleic acid inactivation, deletion, or methylation, as indicative of decreased expression levels. Stated differently, the invention may be practiced by assaying one or more aspect of the DNA template(s) underlying the expression of each gene sequence, of the RNA used as an intermediate to express the sequence, or of the proteinaceous product expressed by the sequence, as well as proteolytic fragments of such products. As such, the detection of the presence of, amount of, stability of, or degradation (including rate) of, such DNA, RNA and proteinaceous molecules may be used in the practice of the invention.
In some embodiments, all or part of a gene sequence may be amplified and detected by methods such as the polymerase chain reaction (PCR) and variations thereof, such as, but not limited to, quantitative PCR (Q-PCR), reverse transcription PCR (RT-PCR), and real-time PCR (including as a means of measuring the initial amounts of mRNA copies for each sequence in a sample), optionally real-time RT-PCR or real-time Q-PCR. Such methods would utilize one or two primers that are complementary to portions of a gene sequence, where the primers are used to prime nucleic acid synthesis. The newly synthesized nucleic acids are optionally labeled and may be detected directly or by hybridization to a polynucleotide of the invention. The newly synthesized nucleic acids may be contacted with polynucleotides (containing gene sequences) of the invention under conditions which allow for their hybridization. Additional methods to detect the expression of expressed nucleic acids include RNAse protection assays, including liquid phase hybridizations, and in situ hybridization of cells.
Alternatively, the expression of gene sequences in FFPE samples may be detected as disclosed in U.S. applications 60/504,087, filed Sep. 19, 2003, Ser. No. 10/727,100, filed Dec. 2, 2003, and Ser. No. 10/773,761, filed Feb. 6, 2004 (all three of which are hereby incorporated by reference as if fully set forth). Briefly, the expression of all or part of an expressed gene sequence or transcript may be detected by use of hybridization mediated detection (such as, but not limited to, microarray, bead, or particle based technology) or quantitative PCR mediated detection (such as, but not limited to, real time PCR and reverse transcriptase PCR) as non-limiting examples. The expression of all or part of an expressed polypeptide may be detected by use of immunohistochemistry techniques or other antibody mediated detection (such as, but not limited to, use of labeled antibodies that bind specifically to at least part of the polypeptide relative to other polypeptides) as non-limiting examples. Additional means for analysis of gene expression are available, including detection of expression within an assay for global, or near global, gene expression in a sample (e.g. as part of a gene expression profiling analysis such as on a microarray). Non-limiting examples linear RNA amplification and those described in U.S. patent application Ser. No. 10/062,857 (filed on Oct. 25, 2001), as well as U.S. Provisional Patent Applications 60/298,847 (filed Jun. 15, 2001) and 60/257,801 (filed Dec. 22, 2000), all of which are hereby incorporated by reference in their entireties as if fully set forth.
In embodiments using a nucleic acid based assay to determine expression includes immobilization of one or more gene sequences on a solid support, including, but not limited to, a solid substrate as an array or to beads or bead based technology as known in the art. Alternatively, solution based expression assays known in the art may also be used. The immobilized gene sequence(s) may be in the form of polynucleotides that are unique or otherwise specific to the gene(s) such that the polynucleotides would be capable of hybridizing to the DNA or RNA of said gene(s). These polynucleotides may be the full length of the gene(s) or be short sequences of the genes (up to one nucleotide shorter than the full length sequence known in the art by deletion from the 5′ or 3′ end of the sequence) that are optionally minimally interrupted (such as by mismatches or inserted non-complementary basepairs) such that hybridization with a DNA or RNA corresponding to the genes is not affected. In some embodiments, the polynucleotides used are from the 3′ end of the gene, such as within about 350, about 300, about 250, about 200, about 150, about 100, or about 50 nucleotides from the polyadenylation signal or polyadenylation site of a gene or expressed sequence. Polynucleotides containing mutations relative to the sequences of the disclosed genes may also be used so long as the presence of the mutations still allows hybridization to produce a detectable signal. Thus the practice of the present invention is unaffected by the presence of minor mismatches between the disclosed sequences and those expressed by cells of a subject's sample. A non-limiting example of the existence of such mismatches are seen in cases of sequence polymorphisms between individuals of a species, such as individual human patients within Homo sapiens.
As will be appreciated by those skilled in the art, some gene sequences include 3′ poly A (or poly T on the complementary strand) stretches that do not contribute to the uniqueness of the disclosed sequences. The invention may thus be practiced with gene sequences lacking the 3′ poly A (or poly T) stretches. The uniqueness of the disclosed sequences refers to the portions or entireties of the sequences which are found only in nucleic acids, including unique sequences found at the 3′ untranslated portion thereof. Some unique sequences for the practice of the invention are those which contribute to the consensus sequences for the genes such that the unique sequences will be useful in detecting expression in a variety of individuals rather than being specific for a polymorphism present in some individuals. Alternatively, sequences unique to an individual or a subpopulation may be used. The unique sequences may be the lengths of polynucleotides of the invention as described herein.
In additional embodiments of the invention, polynucleotides having sequences present in the 3′ untranslated and/or non-coding regions of gene sequences are used to detect expression levels in cell containing samples of the invention. Such polynucleotides may optionally contain sequences found in the 3′ portions of the coding regions of gene sequences. Polynucleotides containing a combination of sequences from the coding and 3′ non-coding regions preferably have the sequences arranged contiguously, with no intervening heterologous sequence(s).
Alternatively, the invention may be practiced with polynucleotides having sequences present in the 5′ untranslated and/or non-coding regions of gene sequences to detect the level of expression in cells and samples of the invention. Such polynucleotides may optionally contain sequences found in the 5′ portions of the coding regions. Polynucleotides containing a combination of sequences from the coding and 5′ non-coding regions may have the sequences arranged contiguously, with no intervening heterologous sequence(s). The invention may also be practiced with sequences present in the coding regions of gene sequences.
The polynucleotides of some embodiments contain sequences from 3′ or 5′ untranslated and/or non-coding regions of at least about 16, at least about 18, at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, at least about 32, at least about 34, at least about 36, at least about 38, at least about 40, at least about 42, at least about 44, or at least about 46 consecutive nucleotides. The term “about” as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Other embodiments use polynucleotides containing sequences of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides. The term “about” as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value.
Sequences from the 3′ or 5′ end of gene coding regions as found in polynucleotides of the invention are of the same lengths as those described above, except that they would naturally be limited by the length of the coding region. The 3′ end of a coding region may include sequences up to the 3′ half of the coding region. Conversely, the 5′ end of a coding region may include sequences up the 5′ half of the coding region. Of course the above described sequences, or the coding regions and polynucleotides containing portions thereof, may be used in their entireties.
In another embodiment of the invention, polynucleotides containing deletions of nucleotides from the 5′ and/or 3′ end of gene sequences may be used. The deletions are preferably of 1-5, 5-10, 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-125, 125-150, 150-175, or 175-200 nucleotides from the 5′ and/or 3′ end, although the extent of the deletions would naturally be limited by the length of the sequences and the need to be able to use the polynucleotides for the detection of expression levels.
Other polynucleotides of the invention from the 3′ end of gene sequences include those of primers and optional probes for quantitative PCR. Preferably, the primers and probes are those which amplify a region less than about 750, less than about 700, less than about 650, less than about 6000, less than about 550, less than about 500, less than about 450, less than about 400, less than about 350, less than about 300, less than about 250, less than about 200, less than about 150, less than about 100, or less than about 50 nucleotides from the from the polyadenylation signal or polyadenylation site of a gene or expressed sequence. The size of a PCR amplicon of the invention may be of any size, including at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides, all with inclusion of the portion complementary to the PCR primers used.
Other polynucleotides for use in the practice of the invention include those that have sufficient homology to gene sequences to detect their expression by use of hybridization techniques. Such polynucleotides preferably have about or 95%, about or 96%, about or 97%, about or 98%, or about or 99% identity with the gene sequences to be used. Identity is determined using the BLAST algorithm, as described above. The other polynucleotides for use in the practice of the invention may also be described on the basis of the ability to hybridize to polynucleotides of the invention under stringent conditions of about 30% v/v to about 50% formamide and from about 0.01M to about 0.15M salt for hybridization and from about 0.01M to about 0.15M salt for wash conditions at about 55 to about 65° C. or higher, or conditions equivalent thereto.
In a further embodiment of the invention, a population of single stranded nucleic acid molecules comprising one or both strands of a human gene sequence is provided as a probe such that at least a portion of said population may be hybridized to one or both strands of a nucleic acid molecule quantitatively amplified from RNA of a cell or sample of the invention. The population may be only the antisense strand of a human gene sequence such that a sense strand of a molecule from, or amplified from, a cell may be hybridized to a portion of said population. The population preferably comprises a sufficiently excess amount of said one or both strands of a human gene sequence in comparison to the amount of expressed (or amplified) nucleic acid molecules containing a complementary gene sequence.
The invention further provides a method of classifying a human tumor sample by detecting the expression levels of about 5 to 49 transcribed sequences in a nucleic acid or cell containing sample obtained from a human subject, and classifying the sample as containing a tumor cell of a tumor type found in humans to the exclusion of one or more other human tumor types. In some embodiments, the method may be used to classify a sample as being, or having cells of, one of the 53 tumor types listed above to the exclusion of one or more of the other 52. In other embodiments, the method is used to classify a sample as being, or having cells of, one of the 34 tumor types listed above to the exclusion of one or more of the other 33 tumor types. In further embodiments, the method is used to classify a sample as being, or having cells of, one of the 39 tumor types listed above to the exclusion of one or more of the other 38 tumor types.
The invention also provides a method for classifying tumor samples as being one of a subset of the possible tumor types described herein by detecting the expression levels of 50 or more transcribed sequences in a nucleic acid containing tumor sample obtained from a human subject, and classifying the sample as being one of a number of tumor types found in humans to the exclusion of one or more other human tumor types. In some embodiments of the invention, the number of other tumor types is from 1 to about 3, more preferably from 1 to about 5, from 1 to about 7, or from 1 to about 9 or about 10. In other embodiments, the number of tumor types are all of the same tissue or organ origin such as those listed above. This aspect of the invention is related to the above discussion of FIG. 10 and of trading off specificity in favor of increased confidence, and may be advantageously applied to situations where the classification of a sample as a single tumor type is at a level of accuracy or performance that can be improved by classifying the sample as one of a subset of possible tumor types.
In additional embodiments, the invention may be practiced by analyzing gene expression from single cells or homogenous cell populations which have been dissected away from, or otherwise isolated or purified from, contaminating cells of a sample as present in a simple biopsy. One advantage provided by these embodiments is that contaminating, non-tumor cells (such as infiltrating lymphocytes or other immune system cells) may be removed as so be absent from affecting the genes identified or the subsequent analysis of gene expression levels as provided herein. Such contamination is present where a biopsy is used to generate gene expression profiles.
In further embodiments of the invention utilizing Q-PCR or reverse transcriptase Q-PCR as the assay platform, the expression levels of gene sequences of the invention may be compared to expression levels of reference genes in the same sample or a ratio of expression levels may be used. This provides a means to “normalize” the expression data for comparison of data on a plurality of known tumor types and a cell containing sample to be assayed. While a variety of reference genes may be used, the invention may also be practiced with the use of 8 particular reference gene sequences that were identified for use with the set of 39 tumor types. Moreover, the Q-PCR may be performed in whole or in part with use of a multiplex format.
mRNA sequences corresponding to the 8 reference sequences are provided in Example 6 (Sequence Listing) along with additional identifying information. The listing of the identifying information, including accession numbers and other information, is provided by the following.


>Hs.77031_mRNA_1 gi\|16741772\|gb\|BC016680.1\|BC016680 Homo sapiens clone
MGC:21349 IMAGE:4338754 polyA=3
>Hs.77541_mRNA_1 gi\|12804364\|gb\|BC003043.1\|BC003043 Homo sapiens clone
MGC:4370 IMAGE:2822973 polyA=3
>Hs.7001_mRNA_1 gi\|6808256\|emb\|AL137727.1\|HSM802274 Homo sapiens mRNA; cDNA
DKFZp434M0519 (from clone DKFZp434M0519); partial cds polyA=3
>Hs.302144_mRNA_1 gi\|11493400\|gb\|AF130047.1\|AF130047 Homo sapiens clone
FLB3020 polyA=0
>Hs.26510_mRNA_2 gi\|11345385\|gb\|AF308803.1\|AF308803 Homo sapiens chromosome
15 map 15q26 polyA=3
>Hs.324709_mRNA_2 gi\|12655026\|gb\|BC001361.1\|BC001361 Homo sapiens clone
MGC:2474 IMAGE:3050694 polyA=2
>Hs.65756_mRNA_3 gi\|3641494\|gb\|AF035154.1\|AF035154 Homo sapiens chromosome
16 map 16p13.3 polyA=3
>Hs.165743_mRNA_2 gi\|13543889\|gb\|BC006091.1\|BC006091 Homo sapiens clone
MGC:12673 IMAGE:3677524 polyA=3

Detection of expression of any of the above reference sequences may be by the same or different methodology as for the other gene sequences described above. In some embodiments of the invention, the expression levels of gene sequences is measured by detection of expressed sequences in a cell containing sample as hybridizing to the following oligonucleotides, which correspond to the above sequences as indicated by the accession numbers provided.

	>BC006091
	TCATCTTCACCAAACCAGTCCGAGGGGTCG

	AAGCCAGACACGAGAGGAAGAGGGTCCTGG

	>BC003043
	CTCTGCTCCTGCTCCTGCCTGCATGTTCTC

	TCTGTTGTTGGAGCCTGGAGCCTTGCTCTC

	>AF130047
	TGCTCCCGGCTGTCCTCCTCTCCTCTTCCC

	TAGTGAGTGGTTAATGAGTGTTAATGCCTA

	>AF035154
	CCCCATCTCTAAAACCAGTAAATCAGCCAG

	CGAATACCCGGAAGCAAGATGCACAGGCGG

	>BC001361
	CCAGAAACAAGGAAGAGGAAAGACAAAGGG

	AAGGGACGGGAGCCCTGGAGAAGCCCGACC

	>AF308803
	AAGTACAACCCATGCTGCTAAGATGCGAGC

	AGGAAGAGGCATCCTTTGCTAAATCCTGTT

	>BC016680
	ACCTCACCCCTGCCCGGCCCAAGCTCTACT

	TGTGTACAGTGTATATTGTATAATAGACAA

	>AL137727
	TTCCCTTAATTCCTCCTCCCGACCTTTTTT

	ACCCCCCCAGTTGCAGTATTTAACTGGGCT

In an additional aspect, the methods provided by the present invention may also be automated in whole or in part. This includes the embodiment of the invention in software. Non-limiting examples include processor executable instructions on one or more computer readable storage devices wherein said instructions direct the classification of tumor samples based upon gene expression levels as described herein. Additional processor executable instructions on one or more computer readable storage devices are contemplated wherein said instructions cause representation and/or manipulation, via a computer output device, of the process or results of a classification method.
The invention includes software and hardware embodiments wherein the gene expression data of a set of gene sequences in a plurality of known tumor types is embodied as a data set. In some embodiments, the gene expression data set is used for the practice of a method of the invention. The invention also provides computer related means and systems for performing the methods disclosed herein. In some embodiments, an apparatus for classifying a cell containing sample is provided. Such an apparatus may comprise a query input configured to receive a query storage configured to store a gene expression data set, as described herein, received from a query input; and a module for accessing and using data from the storage in a classification algorithm as described herein. The apparatus may further comprise a string storage for the results of the classification algorithm, optionally with a module for accessing and using data from the string storage in an output algorithm as described herein.
The steps of a method, process, or algorithm described in connection with the embodiments disclosed herein may be embodied directly in hardware, in a software module executed by a processor, or in a combination of the two. The various steps or acts in a method or process may be performed in the order shown, or may be performed in another order. Additionally, one or more process or method steps may be omitted or one or more process or method steps may be added to the methods and processes. An additional step, block, or action may be added in the beginning, end, or intervening existing elements of the methods and processes.
A further aspect of the invention provides for the use of the present invention in relation to clinical activities. In some embodiments, the determination or measurement of gene expression as described herein is performed as part of providing medical care to a patient, including the providing of diagnostic services in support of providing medical care. Thus the invention includes a method in the medical care of a patient, the method comprising determining or measuring expression levels of gene sequences in a cell containing sample obtained from a patient as described herein. The method may further comprise the classifying of the sample, based on the determination/measurement, as including a tumor cell of a tumor type or tissue origin in a manner as described herein. The determination and/or classification may be for use in relation to any aspect or embodiment of the invention as described herein.
The determination or measurement of expression levels may be preceded by a variety of related actions. In some embodiments, the measurement is preceded by a determination or diagnosis of a human subject as in need of said measurement. The measurement may be preceded by a determination of a need for the measurement, such as that by a medical doctor, nurse or other health care provider or professional, or those working under their instruction, or personnel of a health insurance or maintenance organization in approving the performance of the measurement as a basis to request reimbursement or payment for the performance.
The measurement may also be preceded by preparatory acts necessary to the actual measuring. Non-limiting examples include the actual obtaining of a cell containing sample from a human subject; or receipt of a cell containing sample; or sectioning a cell containing sample; or isolating cells from a cell containing sample; or obtaining RNA from cells of a cell containing sample; or reverse transcribing RNA from cells of a cell containing sample. The sample may be any as described herein for the practice of the invention.
In additional embodiments, the invention provides for a method of ordering, or receiving an order for, the performance of a method in the medical care of a patient or other method of the invention. The ordering may be made by a medical doctor, a nurse, or other health care provider, or those working under their instruction, while the receiving, directly or indirectly, may be made by any person who performs the method(s). The ordering may be by any means of communication, including communication that is written, oral, electronic, digital, analog, telephonic, in person, by facsimile, by mail, or otherwise passes through a jurisdiction within the United States.
The invention further provides methods in the processing of reimbursement or payment for a test, such as the above method in the medical care of a patient or other method of the invention. A method in the processing of reimbursement or payment may comprise indicating that 1) payment has been received, or 2) payment will be made by another payer, or 3) payment remains unpaid on paper or in a database after performance of an expression level detection, determination or measurement method of the invention. The database may be in any form, with electronic forms such as a computer implemented database included within the scope of the invention. The indicating may be in the form of a code (such as a CPT code) on paper or in the database. The “another payer” may be any person or entity beyond that to whom a previous request for reimbursement or payment was made.
Alternative, the method may comprise receiving reimbursement or payment for the technical or actual performance of the above method in the medical care of a patient; for the interpretation of the results from said method; or for any other method of the invention. Of course the invention also includes embodiments comprising instructing another person or party to receive the reimbursement or payment. The ordering may be by any communication means, including those described above. The receipt may be from any entity, including an insurance company, health maintenance organization, governmental health agency, or a patient as non-limiting examples. The payment may be in whole or in part. In the case of a patient, the payment may be in the form of a partial payment known as a co-pay.
In yet another embodiment, the method may comprise forwarding or having forwarded a reimbursement or payment request to an insurance company, health maintenance organization, governmental health agency, or to a patient for the performance of the above method in the medical care of a patient or other method of the invention. The request may be by any communication means, including those described above.
In a further embodiment, the method may comprise receiving indication of approval for payment, or denial of payment, for performance of the above method in the medical care of a patient or other method of the invention. Such an indication may come from any person or party to whom a request for reimbursement or payment was made. Non-limiting examples include an insurance company, health maintenance organization, or a governmental health agency, like Medicare or Medicaid as non-limiting examples. The indication may be by any communication means, including those described above.
An additional embodiment is where the method comprises sending a request for reimbursement for performance of the above method in the medical care of a patient or other method of the invention. Such a request may be made by any communication means, including those described above. The request may have been made to an insurance company, health maintenance organization, federal health agency, or the patient for whom the method was performed.
A further method comprises indicating the need for reimbursement or payment on a form or into a database for performance of the above method in the medical care of a patient or other method of the invention. Alternatively, the method may simply indicate the performance of the method. The database may be in any form, with electronic forms such as a computer implemented database included within the scope of the invention. The indicating may be in the form of a code (such as a CPT code) on paper or in the database.
In the above methods in the medical care of a patient or other method of the invention, the method may comprise reporting the results of the method, optionally to a health care facility, a health care provider or professional, a doctor, a nurse, or personnel working therefor. The reporting may also be directly or indirectly to the patient. The reporting may be by any means of communication, including those described above.
The invention further provides kits for the determination or measurement of gene expression levels in a cell containing sample as described herein. A kit will typically comprise one or more reagents to detect gene expression as described herein for the practice of the present invention. Non-limiting examples include polynucleotide probes or primers for the detection of expression levels, one or more enzymes used in the methods of the invention, and one or more tubes for use in the practice of the invention. In some embodiments, the kit will include an array, or solid media capable of being assembled into an array, for the detection of gene expression as described herein. In other embodiments, the kit may comprise one or more antibodies that is immunoreactive with epitopes present on a polypeptide which indicates expression of a gene sequence. In some embodiments, the antibody will be an antibody fragment.
A kit of the invention may also include instructional materials disclosing or describing the use of the kit or a primer or probe of the present invention in a method of the invention as provided herein. A kit may also include additional components to facilitate the particular application for which the kit is designed. Thus, for example, a kit may additionally contain means of detecting the label (e.g. enzyme substrates for enzymatic labels, filter sets to detect fluorescent labels, appropriate secondary labels such as a sheep anti-mouse-HRP, or the like). A kit may additionally include buffers and other reagents recognized for use in a method of the invention.
Having now generally described the invention, the same will be more readily understood through reference to the following examples which are provided by way of illustration, and are not intended to be limiting of the present invention, unless specified.

EXAMPLES

Example 1: Information Capacity of Random Gene Sets

Subsets of 100 randomly selected expressed gene sequences used to classify among 39 tumor types were tested for their ability to classify among subsets of the 39 tumor types. The expression levels of random combinations of 5, 10, 15, 20, 25, 30, 35, 40, 45, and 49 (each combination sampled 10 times) of the 100 expressed sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to all 39 types. FIG. 1 shows the classification capability of various gene sets are shown relative to the number of tumor types classified. As expected, a higher number of gene sequences are needed to classify tumor types with higher accuracies. FIG. 2 shows the classification performance for various numbers of tumor types relative to the number of gene sequences used.
The GenBank accession numbers of the 100 gene sequences are AF269223, BC006286, AK025501, AJ002367, AI469140, AW013883, NM_001238, AI476350, BC006546, AI041212, BF724944, AI376951, R56211, BC006393, X13274, BC001133, N62397, BC000885, AK001588, AK057901, AF146760, AI951287, AK025604, BC007581, BC015025, R43102, AW449550, AI922539, AI684144, AI277662, BC015999, AW444656, BC011612, BC015401, BF447279, BC009956, AL050163, BC001248, BE672684, AL137353, BC001340, U45975, BE856598, BC009060, AL137728, AA713797, AL583913, AK054617, AI028262, AI753041, BG939593, AL080179, AA814915, AF131798, AI961568, BC009849, AK021603, BC012561, AI570494, BC006973, AW294857, BC004952, AK026535, AI923614, AW082090, AI005513, AF339768, AK023167, AF169693, AF076249, BC007662, BC015520, AI814187, AI565381, AW271626, AK024120, AF139065, BC014075, AI887245, AF257081, AI767898, AF070634, AF155132, X69804, U65579, NM_004933, AI655104, AW131780, AI650407, AF131774, AA814057, AJ311123, BC009702, AF264036, AL161961, AJ010857, AF106912, AK023542, AF073518, and D83032. They were indexed from 1 to 100, and representative random sets used in the invention are as follows:
For 2 genes, genes 33 and 63, genes 17 and 72, genes 64 and 21, genes 48 and 25, genes 88 and 54, genes 80 and 32, genes 24 and 99, genes 14 and 31, genes 80 and 23, and genes 18 and 34 were used as the 10 random sets.
For 5 genes, set 1, genes 27, 97, 56, 88, and 50 were used. In set 2, genes 24, 26, 35, 48, and 83 were used. In set 3, genes 46, 62, 75, 91, and 2 were used. In set 4, genes 19, 61, 34, 87, and 13 were used. In set 5, genes 56, 32, 66, 20, and 55 were used. In set 6, genes 90, 21, 6, 78, and 66 were used. In set 7, genes 73, 47, 3, 82, and 86 were used. In set 8, genes 74, 39, 13, 7, and 67 were used. In set 9, genes 34, 1, 24, 85, and 62 were used. In set 10, genes 23, 89, 15, 54, and 98 were used.
For 10 genes, set 1, genes 11, 58, 90, 40, 20, 44, 10, 78, 72, and 74 were used. In set 2, genes 79, 71, 42, 48, 93, 56, 55, 14, 92, and 52 were used. In set 3, genes 62, 53, 52, 19, 98, 26, 76, 65, 33, and 40 were used. In set 4, genes 94, 8, 16, 99, 58, 19, 97, 92, 76, and 86 were used. In set 5, genes 18, 97, 16, 94, 84, 52, 11, 24, 89, and 92 were used. In set 6, genes 12, 42, 45, 51, 2, 75, 63, 28, 13, and 58 were used. In set 7, genes 67, 98, 55, 32, 82, 42, 2, 45, 37, and 23 were used. In set 8, genes 40, 43, 69, 68, 13, 97, 35, 3, 44, and 42 were used. In set 9, genes 69, 47, 96, 80, 100, 50, 42, 26, 65, and 17 were used. In set 10, genes 83, 84, 69, 67, 19, 85, 35, 11, 70, and 64 were used.
For 15 genes, set 1, genes 98, 81, 43, 63, 18, 56, 19, 97, 47, 13, 48, 99, 75, 45, and 83 were used. In set 2, genes 5, 72, 31, 59, 81, 40, 92, 3, 23, 50, 57, 74, 62, 21, and 93 were used. In set 3, genes 11, 69, 91, 100, 38, 1, 73, 64, 90, 26, 62, 2, 37, 23, and 18 were used. In set 4, genes 76, 9, 53, 4, 11, 41, 77, 44, 87, 51, 54, 49, 43, 56, and 67 were used. In set 5, genes 55, 34, 13, 89, 52, 74, 96, 80, 48, 22, 31, 39, 43, 91, and 54 were used. In set 6, genes 59, 88, 15, 90, 4, 73, 93, 7, 10, 18, 98, 83, 43, 3, and 5 were used. In set 7, genes 68, 91, 77, 33, 88, 94, 95, 41, 46, 27, 36, 51, 97, 7, and 2 were used. In set 8, genes 7, 10, 78, 40, 70, 84, 55, 1, 98, 22, 99, 91, 8, 17, and 89 were used. In set 9, genes 65, 10, 38, 8, 77, 98, 37, 43, 93, 99, 86, 16, 82, 27, and 9 were used. In set 10, genes 97, 27, 78, 38, 24, 19, 55, 47, 77, 13, 45, 25, 43, 70, and 68 were used.
For 20 genes, set 1, genes 41, 94, 38, 76, 35, 65, 92, 26, 49, 7, 85, 54, 77, 66, 98, 15, 86, 69, 70, and 67 were used. In set 2, genes 43, 87, 1, 81, 7, 14, 94, 28, 25, 55, 100, 41, 18, 47, 96, 89, 26, 53, 29, and 32 were used. In set 3, genes 48, 80, 90, 99, 50, 98, 36, 91, 6, 41, 61, 96, 74, 66, 9, 5, 16, 18, 20, and 1 were used. In set 4, genes 49, 58, 73, 24, 94, 22, 41, 52, 18, 19, 63, 91, 74, 37, 59, 95, 53, 87, 72, and 13 were used. In set 5, genes 67, 74, 2, 98, 46, 69, 5, 42, 22, 66, 60, 20, 100, 80, 24, 76, 63, 9, 39, and 15 were used. In set 6, genes 10, 74, 50, 92, 69, 68, 52, 56, 63, 71, 11, 17, 29, 64, 88, 59, 25, 94, 35, and 57 were used. In set 7, genes 97, 72, 16, 19, 14, 42, 70, 31, 29, 13, 22, 37, 95, 69, 87, 39, 18, 81, 58, and 100 were used. In set 8, genes 5, 3, 18, 91, 77, 19, 82, 31, 92, 22, 93, 45, 76, 84, 46, 100, 53, 99, 89, and 42 were used. In set 9, genes 62, 3, 85, 37, 34, 93, 52, 40, 74, 25, 86, 57, 33, 60, 20, 77, 78, 17, 28, and 13 were used. In set 10, genes 22, 26, 23, 39, 35, 10, 43, 32, 65, 38, 54, 45, 8, 17, 90, 20, 83, 60, 6, and 58 were used.
For 25 genes, set 1, genes 21, 28, 50, 27, 8, 48, 74, 80, 38, 96, 71, 15, 89, 84, 32, 26, 55, 36, 29, 68, 13, 7, 18, 63, and 72 were used. In set 2, genes 61, 38, 59, 92, 3, 80, 33, 68, 79, 70, 44, 26, 95, 63, 85, 27, 60, 43, 75, 96, 42, 99, 58, 48, and 91 were used. In set 3, genes 75, 83, 78, 5, 99, 56, 26, 36, 57, 23, 37, 28, 88, 16, 63, 2, 72, 59, 9, 80, 52, 91, 62, 3, and 27 were used. In set 4, genes 48, 75, 84, 83, 88, 29, 13, 9, 98, 6, 31, 63, 45, 5, 51, 52, 39, 22, 100, 91, 74, 12, 94, 21, and 8 were used. In set 5, genes 79, 84, 47, 43, 26, 37, 46, 19, 85, 91, 2, 10, 81, 89, 38, 71, 17, 57, 7, 93, 31, 87, 29, 78, and 73 were used. In set 6, genes 62, 93, 83, 42, 97, 96, 78, 98, 47, 22, 67, 48, 89, 95, 24, 81, 16, 45, 8, 90, 66, 64, 2, 3, and 58 were used. In set 7, genes 100, 34, 58, 28, 104, 35, 88, 76, 6, 30, 83, 81, 67, 36, 39, 87, 66, 45, 20, 15, 86, 56, 55, and 95 were used. In set 8, genes 17, 43, 50, 63, 47, 58, 95, 32, 79, 60, 16, 91, 86, 22, 97, 21, 9, 55, 72, 78, 77, 45, 100, 14, and 30 were used. In set 9, genes 24, 67, 60, 94, 59, 14, 70, 84, 8, 89, 63, 23, 39, 11, 81, 42, 33, 3, 12, 93, 54, 35, 78, 73, and 90 were used. In set 10, genes 11, 2, 19, 62, 13, 51, 30, 80, 81, 82, 52, 34, 67, 57, 25, 95, 93, 39, 26, 48, 44, 89, 61, 17, and 18 were used.
For 30 genes, set 1, genes 30, 97, 54, 21, 34, 9, 56, 71, 62, 14, 24, 23, 89, 61, 76, 41, 29, 67, 94, 22, 88, 4, 40, 33, 38, 78, 82, 66, 84, and 100 were used. In set 2, genes 89, 41, 56, 43, 98, 44, 35, 26, 19, 86, 15, 67, 8, 69, 3, 76, 48, 17, 55, 31, 25, 91, 72, 36, 18, 82, 37, 50, 9, and 75 were used. In set 3, genes 28, 39, 78, 15, 65, 93, 66, 29, 88, 35, 49, 69, 50, 9, 53, 80, 81, 95, 76, 44, 48, 64, 83, 11, 70, 33, 73, 96, 56, and 92 were used. In set 4, genes 4, 2, 19, 6, 11, 84, 94, 44, 60, 37, 29, 97, 53, 83, 98, 45, 65, 9, 85, 35, 20, 89, 10, 17, 23, 74, 70, 41, 18, and 76 were used. In set 5, genes 27, 4, 43, 1, 10, 95, 88, 74, 77, 47, 63, 81, 31, 9, 41, 100, 87, 57, 8, 79, 24, 6, 26, 20, 55, 61, 34, 42, 25, and 39 were used. In set 6, genes 47, 67, 98, 56, 37, 44, 5, 70, 48, 12, 20, 86, 83, 89, 27, 59, 19, 54, 69, 97, 43, 71, 58, 82, 8, 50, 51, 10, 25, and 72 were used. In set 7, genes 100, 99, 37, 58, 44, 60, 39, 3, 59, 96, 50, 68, 94, 69, 83, 90, 17, 4, 5, 67, 88, 56, 29, 79, 23, 1, 38, 25, 49, and 74 were used. In set 8, genes 26, 23, 58, 47, 6, 68, 41, 31, 16, 64, 19, 75, 36, 32, 87, 2, 12, 97, 73, 21, 53, 78, 15, 94, 1, 20, 79, 81, 70, and 7 were used. In set 9, genes 61, 48, 78, 75, 12, 36, 37, 66, 91, 2, 92, 32, 8, 26, 6, 82, 14, 68, 4, 88, 39, 89, 43, 41, 40, 87, 69, 74, 42, and 9 were used. In set 10, genes 58, 99, 60, 39, 50, 25, 22, 57, 48, 85, 24, 10, 97, 68, 36, 38, 93, 62, 52, 56, 34, 18, 32, 64, 95, 81, 74, 88, 61, and 96 were used.
For 35 genes, set 1, genes 52, 68, 22, 92, 43, 75, 20, 62, 15, 76, 99, 61, 64, 36, 12, 66, 24, 21, 31, 88, 25, 6, 93, 91, 55, 74, 69, 90, 23, 4, 80, 72, 97, 58, and 1 were used. In set 2, genes 48, 21, 68, 16, 96, 10, 1, 69, 36, 20, 3, 14, 59, 53, 12, 84, 90, 17, 9, 65, 4, 32, 75, 81, 88, 37, 38, 5, 94, 60, 64, 45, 7, 43, and 55 were used. In set 3, genes 33, 95, 59, 86, 83, 76, 36, 55, 90, 22, 62, 98, 34, 46, 4, 87, 5, 66, 38, 78, 97, 100, 71, 25, 30, 2, 21, 99, 12, 54, 9, 14, 81, 32, and 52 were used. In set 4, genes 27, 64, 40, 59, 63, 100, 50, 19, 1, 10, 96, 2, 34, 28, 67, 26, 87, 41, 15, 57, 33, 11, 94, 66, 82, 6, 52, 55, 84, 47, 97, 83, 80, 62, and 5 were used. In set 5, genes 99, 86, 92, 72, 83, 48, 79, 46, 91, 2, 90, 9, 23, 44, 85, 31, 38, 81, 76, 54, 71, 14, 3, 13, 62, 11, 39, 4, 95, 36, 20, 30, 75, 63, and 51 were used. In set 6, genes 41, 89, 81, 29, 86, 95, 34, 42, 50, 9, 45, 21, 64, 84, 74, 91, 69, 98, 57, 79, 39, 87, 93, 63, 26, 82, 2, 59, 30, 71, 83, 38, 77, 24, and 73 were used. In set 7, genes 87, 60, 59, 98, 43, 38, 28, 64, 29, 92, 22, 27, 40, 33, 69, 71, 73, 79, 15, 70, 32, 90, 76, 93, 6, 50, 55, 9, 49, 54, 36, 5, 48, 19, and 10 were used. In set 8, genes 100, 70, 98, 79, 91, 23, 37, 29, 73, 65, 78, 31, 3, 11, 30, 51, 16, 40, 95, 94, 62, 38, 67, 39, 82, 72, 22, 5, 87, 57, 6, 75, 35, 99, and 46 were used. In set 9, genes 46, 61, 59, 86, 29, 74, 56, 89, 52, 26, 54, 20, 84, 97, 33, 71, 14, 36, 38, 49, 28, 60, 19, 90, 11, 42, 87, 92, 82, 21, 94, 3, 22, 2, and 39 were used. In set 10, genes 31, 76, 77, 27, 72, 38, 42, 36, 53, 82, 61, 39, 98, 81, 34, 80, 22, 100, 8, 32, 17, 21, 28, 56, 59, 29, 55, 5, 62, 40, 90, 87, 24, 68, and 37 were used.
For 40 genes, set 1, genes 64, 50, 46, 22, 51, 6, 47, 12, 2, 30, 45, 7, 63, 55, 91, 90, 80, 49, 71, 8, 79, 82, 77, 76, 97, 5, 95, 11, 32, 70, 20, 62, 38, 26, 41, 58, 44, 87, 35, and 23 were used. In set 2, genes 44, 26, 16, 12, 30, 45, 71, 90, 37, 68, 32, 70, 58, 43, 51, 6, 62, 92, 87, 20, 56, 5, 47, 48, 86, 29, 98, 22, 59, 76, 8, 79, 64, 14, 50, 3, 54, 83, 96, and 80 were used. In set 3, genes 20, 34, 57, 70, 39, 15, 25, 33, 78, 51, 87, 46, 67, 80, 28, 52, 66, 72, 22, 88, 97, 3, 90, 6, 82, 42, 41, 94, 85, 61, 54, 84, 14, 9, 81, 19, 7, 91, 23, and 40 were used. In set 4, genes 61, 46, 64, 71, 35, 58, 100, 23, 95, 17, 87, 68, 54, 8, 50, 4, 27, 49, 47, 52, 53, 28, 24, 34, 45, 2, 89, 48, 3, 65, 42, 9, 92, 36, 6, 84, 51, 60, 77, and 94 were used. In set 5, genes 28, 97, 21, 43, 22, 89, 94, 87, 99, 5, 4, 20, 13, 61, 37, 42, 72, 62, 7, 12, 31, 23, 60, 98, 48, 38, 53, 56, 29, 69, 26, 82, 24, 74, 86, 10, 67, 2, 47, and 46 were used. In set 6, genes 12, 74, 96, 77, 78, 72, 53, 87, 47, 29, 40, 98, 52, 22, 69, 3, 58, 97, 60, 48, 55, 80, 57, 39, 50, 89, 71, 9, 63, 51, 21, 23, 73, 32, 20, 19, 25, 5, 38, and 46 were used. In set 7, genes 88, 79, 54, 44, 37, 36, 32, 91, 47, 50, 60, 92, 82, 80, 46, 19, 98, 20, 76, 29, 9, 95, 2, 77, 97, 74, 90, 73, 100, 1, 34, 85, 24, 71, 57, 99, 68, 13, 43, and 53 were used. In set 8, genes 23, 39, 7, 64, 20, 27, 69, 43, 38, 89, 50, 3, 16, 79, 83, 72, 65, 66, 32, 30, 100, 82, 28, 22, 54, 84, 53, 75, 59, 37, 34, 49, 12, 86, 71, 97, 26, 88, 70, and 57 were used. In set 9, genes 74, 96, 80, 39, 40, 82, 38, 56, 35, 93, 55, 73, 44, 17, 81, 27, 2, 83, 65, 89, 76, 8, 18, 45, 58, 77, 14, 49, 21, 6, 4, 92, 33, 13, 12, 88, 98, 24, 84, and 36 were used. In set 10, genes 35, 77, 48, 62, 26, 12, 41, 68, 81, 5, 37, 70, 28, 72, 50, 83, 64, 99, 74, 57, 84, 76, 52, 14, 87, 97, 3, 31, 73, 58, 44, 24, 15, 66, 45, 91, 4, 32, 46, and 49 were used.
For 45 genes, set 1, genes 52, 97, 84, 72, 96, 34, 18, 38, 88, 80, 91, 49, 71, 64, 93, 26, 62, 40, 68, 29, 67, 39, 60, 9, 13, 74, 95, 99, 27, 47, 25, 45, 31, 8, 69, 17, 75, 53, 51, 12, 23, 1, 6, 30, and 50 were used. In set 2, genes 97, 80, 55, 32, 94, 84, 28, 3, 6, 48, 17, 41, 65, 37, 79, 34, 61, 83, 35, 49, 27, 38, 43, 2, 24, 77, 25, 71, 58, 14, 8, 30, 46, 98, 82, 75, 22, 72, 26, 74, 93, 66, 73, 1, and 53 were used. In set 3, genes 64, 45, 38, 92, 23, 74, 66, 60, 100, 3, 82, 20, 54, 11, 19, 16, 80, 86, 14, 75, 62, 10, 52, 47, 13, 31, 35, 53, 41, 9, 79, 39, 17, 22, 99, 58, 46, 83, 43, 40, 44, 90, 95, 12, and 81 were used. In set 4, genes 20, 66, 9, 24, 16, 76, 99, 42, 86, 58, 15, 93, 48, 28, 26, 50, 68, 12, 2, 37, 82, 36, 27, 57, 45, 41, 32, 1, 52, 54, 30, 39, 7, 100, 59, 23, 94, 75, 8, 60, 55, 34, 38, 29, and 87 were used. In set 5, genes 66, 88, 73, 53, 51, 69, 36, 87, 78, 40, 58; 76, 31, 65, 56, 42, 100, 68, 5, 18, 17, 91, 45, 22, 74, 82, 1, 44, 67, 43, 10, 63, 79, 92, 6, 72, 80, 75, 9, 30, 19, 61, 99, 3, and 38 were used. In set 6, genes 75, 66, 84, 59, 9, 70, 100, 27, 79, 41, 73, 67, 23, 39, 28, 68, 21, 69, 38, 72, 86, 82, 36, 46, 77, 34, 47, 54, 13, 16, 7, 88, 22, 26, 4, 89, 55, 24, 61, 12, 35, 50, 95, 92, and 80 were used. In set 7, genes 59, 86, 10, 29, 53, 88, 43, 64, 11, 13, 19, 17, 36, 65, 73, 94, 20, 51, 80, 24, 66, 83, 44, 47, 21, 6, 52, 82, 69, 54, 100, 28, 18, 34, 35, 30, 74, 91, 49, 46, 60, 5, 38, 71, and 2 were used. In set 8, genes 77, 32, 55, 44, 6, 98, 94, 19, 10, 71, 72, 85, 67, 75, 78, 88, 90, 58, 89, 27, 69, 42, 31, 47, 1, 37, 52, 7, 57, 45, 11, 83, 49, 46, 34, 64, 14, 24, 87, 9, 56, 8, 20, 36, and 15 were used. In set 9, genes 4, 27, 83, 61, 46, 15, 35, 26, 51, 54, 23, 38, 100, 7, 42, 58, 44, 8, 22, 37, 20, 89, 56, 91, 70, 29, 11, 19, 87, 99, 21, 65, 72, 75, 49, 40, 45, 30, 43, 48, 63, 3, 18, 74, and 1 were used. In set 10, genes 68, 19, 90, 52, 55, 23, 17, 53, 3, 2, 74, 82, 26, 88, 48, 6, 8, 43, 15, 73, 57, 67, 85, 91, 13, 44, 81, 1, 75, 33, 51, 21, 4, 41, 77, 86, 40, 18, 31, 78, 92, 10, 64, 99, and 69 were used.
Classification of subsets of the 39 tumor types was performed with use of random selections of tumor types from the group of 39. The expression levels of gene sequence sets as described herein were used to classify random combinations of tumor types. Different random sets of tumor types were used with each of the sets of 100, 74, and 90 gene sequences as described in these examples. Representative, and non-limiting, examples of random sets of from 2 to 20 tumor types used are as follows, where the set of 39 tumor types were indexed from 1 to 39.
For 2 tumor types, set 1 used types 26 and 16. Set 2 used types 8 and 5. Set 3 used types 39 and 8. Set 4 used types 27 and 23. Set 5 used types 8 and 19. Set 6 used 12 and 21. Set 7 used types 30 and 15. Set 8 used types 30 and 5. Set 9 used types 18 and 22. Set 10 used types 27 and 26.
For 4 tumor types, set 1 used types 20, 35, 15 and 7. Set 2 used types 36, 1, 28 and 19. Set 3 used types 13, 4, 12 and 21. Set 4 used types 12, 33, 14 and 28. Set 5 used types 6, 28, 5 and 37. Set 6 used types 5, 25, 36 and 15. Set 7 used types 12, 26, 21 and 19. Set 8 used types 19, 3, 20 and 17. Set 9 used types 18, 10, 8 and 9. Set 10 used types 28, 20, 2 and 22.
For 6 tumor types, set 1 used types 27, 3, 10, 39, 11 and 20. Set 2 used types 33, 10, 20, 32, 13 and 19. Set 3 used types 31, 27, 18, 39, 8 and 16. Set 4 used types 25, 28, 10, 12, 7 and 39. Set 5 used types 14, 13, 28, 24, 30 and 36. Set 6 used types 9, 24, 8, 17, 36 and 26. Set 7 used types 20, 1, 34, 26, 6 and 19. Set 8 used types 12, 13, 3, 17, 34 and 22. Set 9 used types 7, 1, 17, 13, 20 and 34. Set 10 used types 5, 11, 25, 29, 28 and 35.
For 8 tumor types, set 1 used types 34, 33, 28, 3, 23, 25, 9 and 29. Set 2 used types 27, 8, 38, 28, 20, 14, 12 and 9. Set 3 used types 29, 21, 19, 1, 13, 26, 11 and 31. Set 4 used types 25, 17, 7, 20, 34, 8, 28 and 10. Set 5 used types 36, 28, 35, 26, 2, 8, 29 and 7. Set 6 used types 10, 23, 2, 27, 33, 21, 25 and 35. Set 7 used types 10, 18, 38, 2, 6, 7, 19 and 32. Set 8 used types 11, 37, 6, 28, 3, 9, 2 and 16. Set 9 used types 22, 2, 10, 8, 17, 19 and 33. Set 10 used types 35, 39, 8, 10, 37, 4, 36 and 6.
For 10 tumor types, set 1 used types 25, 10, 26, 2, 32, 31, 39, 23, 22 and 18. Set 2 used types 12, 35, 6, 16, 20, 3, 39, 36, 11 and 2. Set 3 used types 34, 1, 15, 29, 5, 39, 2, 12, 25 and 18. Set 4 used types 10, 8, 14, 18, 31, 19, 23, 20, 32 and 33. Set 5 used types 10, 18, 37, 15, 4, 35, 33, 24, 39 and 20. Set 6 used types 22, 16, 4, 3, 18, 21, 1, 25, 37 and 13. Set 7 used types 14, 6, 28, 18, 11, 13, 2, 32, 33 and 19. Set 8 used types 39, 2, 38, 4, 34, 8, 25, 6, 32 and 35. Set 9 used types 3, 10, 11, 16, 6, 15, 18, 14, 12 and 26. Set 10 used types 24, 25, 21, 9, 36, 29, 20, 39, 10 and 37.
For 12 tumor types, set 1 used types 26, 20, 4, 12, 2, 31, 38, 18, 16, 39, 3 and 33. Set 2 used types 25, 16, 4, 9, 29, 27, 14, 24, 21, 7, 23 and 2. Set 3 used types 31, 18, 23, 13, 25, 1, 29, 21, 35, 10, 32 and 39. Set 4 used types 8, 34, 23, 9, 35, 14, 25, 21, 2, 33, 18 and 28. Set 5 used types 6, 11, 21, 8, 5, 7, 19, 32, 3, 13, 36 and 9. Set 6 used types 12, 33, 14, 26, 27, 15, 2, 21, 36, 35, 9 and 39. Set 7 used types 26, 29, 32, 17, 31, 19, 6, 5, 20, 34, 2 and 24. Set 8 used types 17, 12, 8, 22, 28, 9, 27, 29, 14, 35, 4 and 32. Set 9 used types 29, 9, 36, 23, 33, 18, 21, 35, 3, 6, 2 and 1. Set 10 used types 1, 3, 35, 29, 22, 27, 8, 23, 2, 36, 14 and 19.
For 14 tumor types, set 1 used types 9, 26, 38, 25, 31, 3, 15, 14, 17, 33, 12, 35, 39 and 16. Set 2 used types 1, 26, 16, 25, 20, 12, 14, 37, 38, 24, 23, 33, 27 and 35. Set 3 used types 11, 21, 35, 38, 32, 34, 27, 39, 16, 15, 4, 5, 13 and 18. Set 4 used types 27, 5, 13, 28, 18, 17, 15, 20, 29, 37, 21, 36, 25 and 14. Set 5 used types 5, 12, 17, 9, 25, 21, 33, 37, 8, 15, 24, 3, 34 and 28. Set 6 used types 11, 19, 34, 26, 9, 6, 32, 14, 27, 29, 30, 16, 24 and 17. Set 7 used types 31, 26, 11, 18, 19, 20, 9, 8, 5, 36, 12, 6, 27 and 38. Set 8 used types 20, 17, 11, 5, 15, 9, 2, 39, 34, 24, 27, 26, 35 and 10. Set 9 used types 1, 14, 39, 30, 17, 6, 10, 35, 31, 33, 15, 29, 32 and 7. Set 10 used types 1, 19, 24, 28, 34, 12, 13, 18, 32, 11, 14, 21, 22 and 25.
For 16 tumor types, set 1 used types 27, 15, 8, 12, 6, 20, 26, 19, 25, 2, 37, 38, 7, 39, 4 and 33. Set 2 used types 17, 18, 28, 5, 6, 31, 25, 13, 8, 20, 37, 36, 35, 9, 23 and 27. Set 3 used types 23, 37, 34, 14, 16, 27, 32, 33, 21, 38, 4, 30, 24, 22, 17 and 25. Set 4 used types 7, 37, 38, 21, 34, 31, 32, 25, 10, 36, 19, 11, 6, 26, 18 and 35. Set 5 used types 9, 32, 12, 24, 20, 13, 38, 21, 39, 23, 36, 18, 37, 22, 5 and 3. Set 6 used types 14, 21, 5, 17, 6, 20, 18, 35, 22, 10, 3, 23, 13, 2, 34 and 26. Set 7 used types 1, 8, 19, 6, 9, 39, 28, 18, 13, 31, 14, 16, 37, 12, 3 and 25. Set 8 used types 32, 36, 28, 38, 9, 33, 2, 5, 4, 11, 19, 18, 13, 8, 12 and 3. Set 9 used types 9, 14, 10, 5, 28, 32, 23, 6, 39, 3, 17, 8, 19, 1, 31 and 12. Set 10 used types 4, 34, 11, 6, 38, 19, 7, 20, 23, 3, 25, 37, 26, 1, 15 and 12.
For 18 tumor types, set 1 used types 15, 24, 39, 35, 7, 30, 16, 13, 20, 3, 26, 4, 12, 10, 34, 25, 21 and 28. Set 2 used types 21, 23, 29, 11, 10, 19, 13, 28, 4, 20, 17, 24, 30, 12, 39, 34, 31 and 9. Set 3 used types 7, 17, 27, 6, 30, 8, 22, 2, 32, 26, 21, 14, 4, 38, 1, 35, 16 and 28. Set 4 used types 17, 13, 20, 33, 10, 3, 16, 22, 1, 38, 2, 9, 28, 5, 6, 19, 12 and 11. Set 5 used types 4, 35, 21, 25, 18, 17, 8, 14, 31, 30, 9, 1, 2, 23, 36, 29, 32 and 37. Set 6 used types 17, 34, 2, 18, 19, 15, 16, 13, 4, 24, 5, 35, 6, 22, 28, 37, 38 and 1. Set 7 used types 34, 26, 12, 25, 27, 3, 17, 7, 2, 32, 9, 36, 21, 19, 22, 8, 20 and 29. Set 8 used types 12, 34, 38, 25, 17, 22, 14, 39, 10, 7, 31, 2, 3, 11, 29, 30, 16 and 24. Set 9 used types 13, 26, 27, 14, 5, 10, 8, 7, 16, 30, 37, 4, 6, 35, 28, 1, 36 and 20. Set 10 used types 15, 2, 17, 23, 26, 28, 36, 38, 12, 6, 19, 37, 20, 14, 9, 39, 11 and 21.
For 20 tumor types, set 1 used types 25, 13, 21, 15, 37, 20, 12, 28, 9, 10, 26, 22, 14, 24, 16, 7, 39, 34, 33 and 4. Set 2 used types 20, 17, 10, 27, 19, 28, 5, 1, 23, 21, 38, 7, 13, 22, 32, 31, 9, 4, 3 and 24. Set 3 used types 17, 13, 7, 20, 11, 38, 34, 3, 15, 12, 5, 39, 9, 10, 4, 35, 27, 6, 21 and 33. Set 4 used types 6, 13, 17, 26, 1, 7, 33, 5, 10, 32, 3, 23, 35, 4, 14, 28, 12, 38, 8 and 27. Set 5 used types 10, 23, 9, 38, 5, 29, 12, 27, 25, 6, 7, 26, 37, 31, 24, 36, 19, 15, 16 and 11. Set 6 used types 30, 24, 21, 11, 23, 25, 8, 9, 7, 31, 27, 5, 14, 29, 1, 19, 16, 12, 22 and 17. Set 7 used types 26, 13, 23, 19, 22, 11, 25, 21, 33, 20, 6, 17, 2, 10, 31, 34, 27, 37, 7 and 9. Set 8 used types 30, 1, 38, 7, 31, 37, 11, 25, 6, 19, 28, 33, 17, 29, 10, 27, 16, 3, 14 and 15. Set 9 used types 15, 19, 26, 24, 5, 33, 11, 2, 13, 18, 31, 22, 32, 20, 23, 6, 10, 25, 36 and 3. Set 10 used types 24, 25, 21, 29, 14, 18, 31, 2, 20, 39, 23, 9, 38, 12, 6, 32, 22, 26, 33 and 7.

Example 4: Specified Gene Sets

A first set of 74 genes and a second set of 90 genes, where the two sets have 38 members in common, were used in the practice of the invention.
Random subsets of about 5 to 49 members of the set of 74 expressed gene sequences were evaluated in a manner analogous to that described in Example 3. Again, the expression levels of random combinations of 5, 10, 15, 20, 25, 30, 35, 40, 45, and 49 (each combination sampled 10 times) of the 74 expressed sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to all 39 types. The resulting data are shown in FIGS. 4-6 .
The members of the 74 gene sequences were indexed from 1 to 74, and representative random sets used in the invention are as follows:
For 2 genes, set 1, genes 64 and 6 were used. For set 2, genes 64 and 13 were used. For set 3, genes 67 and 51 were used. For set 4, genes 51 and 29 were used. For set 5, genes 46 and 12 were used. For set 6, genes 68 and 65 were used. For set 7, genes 6 and 28 were used. For set 8, genes 9 and 55 were used. For set 9, genes 55 and 71 were used. For set 10, genes 63 and 39 were used.
For 5 genes, set 1, genes 8, 64, 50, 54, and 4 were used. In set 2, genes 39, 17, 45, 34, and 15 were used. In set 3, genes 10, 4, 61, 21, and 55 were used. In set 4, genes 59, 37, 21, 23, and 64 were used. In set 5, genes 69, 8, 25, 59, and 63 were used. In set 6, genes 45, 71, 19, 59, and 38 were used. In set 7, genes 21, 43, 14, 48, and 30 were used. In set 8, genes 73, 35, 36, 10, and 9 were used. In set 9, genes 62, 28, 11, 70, and 64 were used. In set 10, genes 8, 16, 70, 18, and 59 were used.
For 10 genes, set 1, genes 49, 72, 38, 68, 52, 21, 1, 10, 2, and 40 were used. In set 2, genes 54, 70, 28, 64, 68, 41, 44, 20, 7, and 2 were used. In set 3, genes 71, 49, 51, 11, 18, 53, 8, 42, 36, and 58 were used. In set 4, genes 72, 15, 35, 3, 23, 8, 2, 48, 22, and 65 were used. In set 5, genes 44, 19, 6, 22, 38, 5, 37, 9, 30, and 14 were used. In set 6, genes 15, 27, 3, 10, 31, 19, 44, 39, 48, and 46 were used. In set 7, genes 70, 30, 9, 33, 63, 71, 32, 34, 20, and 7 were used. In set 8, genes 45, 29, 54, 58, 15, 21, 68, 5, 42, and 62 were used. In set 9, genes 74, 17, 66, 46, 10, 8, 63, 5, 24, and 2 were used. In set 10, genes 33, 2, 34, 19, 60, 71, 42, 51, 70, and 66 were used.
For 15 genes, set 1, genes 13, 22, 26, 67, 64, 40, 68, 71, 4, 28, 24, 33, 46, 69, and 41 were used. In set 2, genes 10, 1, 14, 70, 71, 64, 46, 67, 45, 48, 65, 74, 34, 49, and 37 were used. In set 3, genes 58, 30, 44, 40, 51, 36, 33, 60, 39, 21, 54, 64, 25, 13, and 35 were used. In set 4, genes 63, 70, 60, 32, 31, 16, 49, 65, 38, 5, 72, 47, 40, 2, and 46 were used. In set 5, genes 43, 6, 40, 13, 39, 72, 68, 41, 27, 73, 36, 25, 33, 34, and 1 were used. In set 6, genes 68, 67, 71, 59, 73, 62, 31, 43, 7, 44, 21, 48, 54, 58, and 6 were used. In set 7, genes 16, 50, 61, 62, 27, 2, 21, 1, 41, 28, 68, 35, 17, 47, and 46 were used. In set 8, genes 27, 18, 44, 66, 2, 20, 53, 64, 46, 70, 57, 7, 51, 10, and 45 were used. In set 9, genes 65, 8, 43, 23, 50, 46, 21, 41, 44, 3, 31, 17, 7, 66, and 70 were used. In set 10, genes 16, 14, 61, 51, 39, 33, 43, 31, 53, 65, 74, 42, 29, 9, and 11 were used.
For 20 genes, set 1, genes 14, 60, 6, 71, 74, 16, 62, 39, 56, 44, 32, 72, 18, 42, 66, 49, 1, 9, 69, and 21 were used. In set 2, genes 23, 1, 7, 27, 26, 71, 12, 4, 22, 69, 62, 44, 6, 25, 57, 28, 33, 9, 21, and 51 were used. In set 3, genes 46, 48, 29, 54, 55, 69, 73, 47, 6, 27, 24, 21, 15, 43, 45, 7, 62, 25, 22, and 74 were used. In set 4, genes 12, 65, 24, 73, 45, 57, 49, 63, 61, 1, 58, 10, 2, 18, 8, 51, 67, 69, 59, and 13 were used. In set 5, genes 33, 43, 9, 52, 54, 38, 8, 16, 48, 1, 39, 60, 17, 6, 15, 66, 68, 63, 37, and 42 were used. In set 6, genes 43, 19, 44, 28, 56, 34, 66, 42, 73, 40, 65, 38, 54, 20, 51, 37, 30, 35, 53, and 61 were used. In set 7, genes 61, 6, 20, 4, 34, 53, 70, 38, 35, 46, 36, 16, 1, 23, 68, 12, 59, 71, 65, and 14 were used. In set 8, genes 25, 68, 69, 3, 33, 49, 19, 56, 54, 4, 32, 6, 45, 16, 67, 52, 65, 14, 12, and 40 were used. In set 9, genes 47, 7, 36, 32, 61, 74, 14, 45, 26, 51, 69, 12, 41, 42, 64, 25, 27, 57, 23, and 58 were used. In set 10, genes 27, 13, 3, 17, 51, 7, 37, 43, 20, 12, 52, 21, 25, 2, 5, 32, 62, 47, 4, and 26 were used.
For 25 genes, set 1, genes 57, 61, 31, 38, 3, 7, 72, 43, 32, 23, 28, 71, 48, 17, 2, 49, 10, 30, 66, 12, 69, 41, 20, 63, and 68 were used. In set 2, genes 18, 54, 47, 57, 24, 42, 66, 46, 16, 58, 37, 60, 62, 9, 2, 27, 36, 52, 13, 32, 45, 6, 43, 21, and 56 were used. In set 3, genes 47, 48, 52, 16, 56, 54, 42, 37, 17, 41, 35, 21, 6, 9, 63, 10, 49, 68, 23, 25, 70, 3, 58, 2, and 31 were used. In set 4, genes 50, 10, 25, 16, 68, 15, 29, 73, 27, 63, 3, 17, 28, 66, 19, 13, 4, 9, 36, 48, 23, 57, 59, 26, and 14 were used. In set 5, genes 40, 39, 43, 49, 66, 15, 14, 29, 36, 21, 19, 44, 72, 58, 69, 12, 11, 9, 37, 46, 32, 51, 3, 24, and 6 were used. In set 6, genes 42, 49, 44, 32, 46, 35, 70, 40, 3, 21, 11, 67, 25, 56, 37, 43, 60, 55, 16, 27, 30, 53, 63, 23, and 33 were used. In set 7, genes 70, 27, 68, 17, 64, 65, 18, 69, 10, 67, 42, 23, 48, 14, 31, 11, 55, 25, 52, 34, 13, 45, 12, 29, and 47 were used. In set 8, genes 48, 10, 17, 27, 25, 55, 12, 62, 30, 65, 15, 49, 70, 14, 54, 24, 33, 26, 50, 60, 6, 40, 67, 11, and 2 were used. In set 9, genes 41, 47, 24, 59, 7, 44, 2, 67, 12, 19, 13, 17, 35, 56, 28, 14, 61, 15, 60, 58, 1, 64, 31, 45, and 23 were used. In set 10, genes 42, 72, 41, 38, 57, 27, 4, 13, 9, 43, 34, 28, 8, 62, 64, 46, 12, 70, 21, 66, 16, 7, 48, 3, and 54 were used.
For 30 genes, set 1, genes 16, 47, 67, 9, 22, 10, 64, 72, 46, 6, 60, 74, 3, 68, 57, 63, 14, 54, 58, 30, 28, 18, 70, 73, 52, 39, 34, 61, 12, 21 were used. In set 2, genes 18, 1, 44, 24, 68, 26, 62, 10, 47, 67, 37, 55, 32, 35, 34, 14, 49, 30, 17, 16, 51, 45, 74, 31, 9, 57, 66, 39, 53, and 8 were used. In set 3, genes 58, 45, 55, 39, 22, 32, 9, 49, 31, 13, 51, 56, 28, 12, 3, 59, 74, 35, 42, 67, 69, 47, 66, 18, 52, 57, 43, 5, 26, and 4 were used. In set 4, genes 45, 1, 74, 12, 18, 23, 59, 27, 38, 40, 72, 56, 50, 20, 52, 32, 5, 16, 9, 21, 60, 64, 49, 70, 30, 61, 6, 10, 31, and 24 were used. In set 5, genes 60, 53, 7, 32, 73, 25, 69, 48, 17, 45, 16, 3, 14, 9, 37, 41, 72, 43, 68, 39, 20, 51, 59, 23, 6, 15, 74, 19, 31, and 66 were used. In set 6, genes 47, 54, 9, 38, 60, 33, 40, 12, 57, 45, 26, 56, 11, 27, 67, 25, 69, 59, 68, 7, 61, 72, 23, 21, 28, 48, 29, 65, 37, and 15 were used. In set 7, genes 21, 42, 30, 57, 65, 59, 53, 74, 45, 66, 68, 41, 19, 24, 8, 10, 61, 43, 38, 67, 37, 47, 40, 22, 63, 35, 70, 72, 5, and 6 were used. In set 8, genes 58, 11, 28, 36, 24, 34, 53, 9, 44, 23, 51, 70, 22, 17, 15, 59, 5, 60, 1, 64, 21, 50, 35, 52, 31, 43, 38, 39, 32, and 62 were used. In set 9, genes 43, 30, 63, 7, 60, 40, 39, 1, 48, 17, 69, 57, 6, 62, 19, 38, 36, 13, 66, 64, 25, 31, 65, 47, 27, 16, 53, 68, 37, and 41 were used. In set 10, genes 22, 17, 4, 2, 37, 16, 49, 7, 63, 64, 14, 15, 74, 43, 25, 54, 46, 50, 53, 67, 39, 62, 59, 10, 55, 72, 65, 52, 58, and 19 were used.
For 35 genes, set 1, genes 4, 43, 55, 49, 13, 26, 32, 21, 18, 50, 14, 20, 65, 7, 24, 52, 58, 8, 30, 37, 54, 71, 2, 31, 44, 61, 66, 67, 28, 39, 10, 70, 17, 19, and 45 were used. In set 2, genes 14, 13, 67, 21, 48, 28, 69, 47, 50, 3, 68, 63, 22, 41, 60, 61, 5, 44, 56, 65, 7, 66, 15, 6, 45, 2, 36, 5, 30, 72, 34, 46, 24, 29, and 12 were used. In set 3, genes 67, 25, 58, 11, 17, 16, 3, 69, 21, 1, 59, 26, 72, 41, 47, 2, 34, 24, 10, 19, 33, 5, 50, 9, 71, 20, 62, 8, 68, 61, 23, 37, 35, 60, and 32 were used. In set 4, genes 5, 30, 14, 1, 59, 27, 28, 51, 55, 61, 18, 37, 17, 73, 6, 44, 67, 12, 35, 11, 53, 72, 70, 25, 21, 7, 34, 13, 74, 43, 52, 39, 54, 2, and 19 were used. In set 5, genes 56, 64, 58, 35, 1, 23, 43, 4, 73, 28, 54, 6, 51, 68, 49, 37, 16, 71, 3, 21, 48, 69, 70, 10, 26, 22, 50, 44, 2, 60, 38, 40, 66, 63, and 65 were used. In set 6, genes 72, 49, 51, 44, 19, 28, 1, 11, 3, 40, 33, 41, 70, 29, 48, 62, 50, 4, 47, 60, 68, 10, 61, 32, 20, 13, 22, 59, 65, 64, 67, 21, 35, 39, and 24 were used. In set 7, genes 14, 35, 31, 20, 8, 59, 50, 15, 52, 62, 19, 30, 71, 68, 72, 47, 38, 74, 36, 49, 73, 22, 41, 25, 69, 16, 32, 24, 51, 43, 65, 3, 6, 53, and 29 were used. In set 8, genes 22, 44, 23, 9, 26, 56, 72, 59, 35, 61, 51, 69, 64, 30, 53, 27, 11, 55, 39, 67, 48, 28, 14, 10, 8, 12, 40, 24, 57, 34, 50, 32, 42, 41, and 38 were used. In set 9, genes 15, 7, 27, 6, 67, 9, 26, 57, 30, 37, 58, 23, 42, 11, 36, 52, 32, 29, 62, 21, 41, 61, 64, 18, 40, 35, 66, 1, 2, 56, 16, 3, 55, 10, and 51 were used. In set 10, genes 9, 14, 71, 25, 44, 37, 49, 46, 66, 53, 7, 33, 22, 12, 73, 50, 27, 24, 13, 5, 41, 51, 61, 16, 28, 56, 23, 20, 10, 8, 70, 48, 42, 52, and 34 were used.
For 40 genes, set 1, genes 26, 36, 43, 30, 62, 19, 20, 51, 41, 71, 1, 63, 10, 56, 65, 17, 15, 50, 5, 35, 4, 54, 12, 70, 48, 31, 47, 37, 34, 8, 3, 69, 40, 44, 46, 59, 61, 74, 23, 27 were used. In set 2, genes 1, 4, 38, 24, 37, 69, 21, 52, 13, 2, 63, 51, 30, 16, 27, 58, 74, 20, 32, 53, 59, 31, 50, 10, 42, 8, 54, 36, 5, 47, 70, 41, 12, 46, 28, 19, 35, 9, 61, and 48 were used. In set 3, genes 35, 48, 40, 47, 20, 67, 57, 72, 15, 17, 46, 37, 9, 2, 60, 30, 65, 49, 29, 64, 16, 21, 7, 74, 61, 11, 58, 71, 62, 23, 24, 55, 3, 53, 52, 27, 18, 50, 25, and 66 were used. In set 4, genes 35, 10, 59, 19, 27, 40, 30, 4, 9, 52, 2, 29, 26, 41, 55, 17, 13, 53, 71, 63, 58, 44, 45, 62, 70, 16, 64, 48, 43, 8, 38, 72, 49, 37, 18, 36, 74, 42, 46, and 54 were used. In set 5, genes 16, 61, 1, 10, 20, 51, 22, 6, 43, 65, 66, 24, 30, 9, 14, 40, 32, 74, 18, 71, 15, 28, 52, 31, 56, 55, 23, 4, 58, 36, 60, 54, 25, 63, 27, 64, 50, 29, 44, and 45 were used. In set 6, genes 15, 30, 3, 50, 61, 47, 13, 48, 45, 17, 46, 10, 28, 37, 8, 54, 9, 5, 63, 18, 39, 49, 34, 68, 14, 23, 43, 11, 1, 51, 56, 67, 20, 57, 6, 19, 25, 31, 21, and 12 were used. In set 7, genes 45, 73, 53, 29, 35, 56, 70, 51, 30, 59, 49, 22, 6, 43, 28, 31, 40, 4, 66, 25, 37, 19, 12, 65, 26, 74, 46, 50, 23, 62, 17, 69, 36, 41, 34, 27, 67, 7, 24, and 13 were used. In set 8, genes 62, 30, 38, 41, 18, 13, 49, 71, 68, 47, 50, 70, 66, 5, 23, 33, 27, 56, 6, 7, 34, 28, 26, 58, 53, 46, 16, 52, 72, 42, 10, 54, 67, 64, 12, 8, 19, 57, 73, and 17 were used. In set 9, genes 11, 32, 48, 54, 42, 67, 13, 53, 21, 44, 57, 22, 40, 12, 5, 29, 69, 37, 17, 39, 45, 73, 60, 26, 14, 72, 4, 59, 24, 46, 18, 51, 36, 61, 35, 9, 19, 16, 38, and 28 were used. In set 10, genes 58, 1, 55, 59, 11, 63, 3, 26, 49, 69, 34, 47, 65, 46, 14, 39, 5, 67, 16, 66, 64, 38, 44, 32, 15, 22, 19, 71, 23, 52, 45, 53, 48, 8, 60, 73, 9, 30, 25, and 37 were used.
For 45 genes, set 1, genes 26, 21, 17, 34, 19, 27, 6, 61, 24, 42, 3, 60, 70, 43, 54, 13, 9, 20, 28, 58, 12, 23, 33, 4, 63, 56, 67, 1, 11, 68, 41, 59, 45, 5, 48, 32, 10, 44, 16, 65, 51, 62, 22, 38, and 74 were used. In set 2, genes 21, 41, 67, 5, 51, 53, 28, 25, 31, 60, 52, 17, 50, 11, 29, 45, 2, 32, 71, 13, 68, 22, 74, 33, 48, 56, 62, 42, 26, 14, 61, 23, 9, 46, 66, 10, 64, 59, 54, 69, 27, 47, 44, 34, and 40 were used. In set 3, genes 68, 48, 43, 74, 17, 4, 49, 34, 38, 60, 12, 42, 18, 5, 51, 32, 1, 57, 9, 11, 30, 13, 37, 15, 29, 33, 44, 20, 55, 70, 45, 41, 24, 56, 35, 52, 59, 7, 25, 2, 31, 64, 71, 22, and 39 were used. In set 4, genes 44, 61, 51, 69, 65, 72, 29, 57, 40, 62, 66, 63, 67, 55, 74, 14, 56, 11, 16, 58, 1, 15, 3, 48, 42, 7, 8, 30, 18, 19, 23, 60, 4, 10, 21, 43, 12, 37, 32, 25, 22, 50, 34, 59, and 2 were used. In set 5, genes 67, 54, 33, 41, 5, 61, 3, 10, 2, 71, 73, 53, 25, 42, 44, 23, 9, 38, 45, 62, 32, 46, 40, 8, 66, 49, 16, 24, 68, 69, 21, 52, 20, 6, 48, 11, 57, 39, 22, 31, 63, 36, 34, 35, and 17 were used. In set 6, genes 43, 45, 19, 17, 4, 58, 37, 7, 42, 52, 2, 62, 25, 66, 24, 15, 22, 74, 68, 67, 8, 1, 33, 70, 31, 50, 64, 14, 61, 51, 6, 38, 35, 39, 72, 5, 27, 36, 11, 18, 12, 48, 46, 54, and 71 were used. In set 7, genes 41, 45, 58, 11, 66, 26, 53, 13, 60, 4, 65, 18, 67, 73, 28, 55, 56, 57, 29, 68, 23, 19, 42, 17, 22, 62, 61, 10, 43, 64, 38, 71, 7, 40, 16, 34, 74, 12, 37, 8, 63, 44, 49, 47, and 3 were used. In set 8, genes 47, 40, 59, 14, 50, 71, 1, 57, 19, 28, 6, 34, 68, 4, 30, 20, 31, 33, 38, 39, 17, 41, 24, 65, 70, 61, 3, 35, 45, 11, 9, 8, 73, 42, 26, 23, 46, 72, 25, 64, 16, 53, 62, 18, and 7 were used. In set 9, genes 61, 5, 69, 22, 7, 17, 26, 13, 2, 30, 55, 33, 47, 14, 59, 32, 9, 44, 23, 45, 42, 25, 15, 57, 48, 50, 1, 68, 18, 72, 46, 73, 67, 36, 63, 60, 28, 21, 20, 8, 29, 35, 37, 38, and 71 were used. In set 10, genes 22, 31, 58, 50, 64, 11, 17, 67, 41, 2, 21, 4, 61, 70, 54, 3, 71, 25, 40, 43, 69, 38, 9, 73, 45, 16, 34, 10, 7, 52, 35, 19, 66, 24, 5, 60, 18, 14, 59, 32, 68, 15, 56, 63, and 65 were used.
A similar experiment was performed with random subsets of about 5 to 49 members of the set of 90 expressed gene sequences. Again, the expression levels of random combinations of 5, 10, 15, 20, 25, 30, 35, 40, 45, and 49 (each combination sampled 10 times) of the 90 expressed sequences were used with data from tumor types and then used to predict test random sets of tumor samples (each sampled 10 times) ranging from 2 to all 39 types. The resulting data are shown in FIGS. 7-9 .
The members of the 90 gene sequences were indexed from 1 to 90, and representative random sets used in the invention are as follows:
For 2 genes, set 1, genes 30 and 72 were used. For set 2, genes 65 and 88 were used. For set 3, genes 76 and 88 were used. For set 4, genes 5 and 86 were used. For set 5, genes 30 and 32 were used. For set 6, genes 6 and 59 were used. For set 7, genes 57 and 2 were used. For set 8, genes 49 and 28 were used. For set 9, genes 37 and 35 were used. For set 10, genes 34 and 18 were used.
For 5 genes set 1, genes 1, 83, 59, 36, 66, and 88 were used. In set 2, genes 58, 13, 59, 22, and 64 were used. In set 3, genes 46, 72, 51, 88, and 14 were used. In set 4, genes 23, 74, 22, 27, and 20 were used. In set 5, genes 58, 54, 78, 87, and 50 were used. In set 6, genes 59, 6, 56, 78, and 9 were used. In set 7, genes 30, 78, 69, 83, and 21 were used. In set 8, genes 5, 39, 54, 56, and 55 were used. In set 9, genes 9, 70, 54, 67, and 43 were used. In set 10, genes 80, 81, 63, 90, and 53 were used.
For 10 genes, set 1, genes 70, 17, 45, 5, 2, 37, 6, 76, 39, and 14 were used. In set 2, genes 54, 16, 80, 26, 15, 45, 50, 8, 73, and 48 were used. In set 3, genes 66, 87, 31, 74, 37, 45, 19, 1, 70, and 7 were used. In set 4, genes 85, 17, 78, 61, 23, 59, 27, 18, 58, and 24 were used. In set 5, genes 44, 89, 36, 76, 49, 3, 21, 24, 38, and 69 were used. In set 6, genes 32, 72, 55, 2, 86, 81, 53, 45, 17, and 74 were used. In set 7, genes 27, 55, 62, 33, 32, 84, 21, 45, 23, and 7 were used. In set 8, genes 62, 45, 68, 31, 69, 39, 33, 63, 19, and 22 were used. In set 9, genes 71, 39, 11, 56, 88, 80, 37, 77, 62, and 35 were used. In set 10, genes 38, 83, 41, 47, 66, 87, 10, 4, 88, and 22 were used.
For 15 genes, set 1, genes 61, 17, 64, 14, 1, 41, 72, 47, 69, 48, 49, 70, 12, 20, and 35 were used. In set 2, genes 26, 49, 69, 31, 84, 42, 24, 56, 82, 12, 29, 2, 21, 15, and 71 were used. In set 3, genes 54, 62, 8, 32, 58, 65, 39, 44, 35, 22, 34, 77, 43, 83, and 75 were used. In set 4, genes 62, 50, 57, 80, 28, 83, 32, 56, 14, 2, 3, 48, 67, 79, and 72 were used. In set 5, genes 55, 58, 77, 68, 90, 76, 17, 72, 85, 34, 43, 33, 62, 6, and 64 were used. In set 6, genes 41, 63, 90, 9, 25, 35, 2, 14, 65, 87, 11, 36, 10, 79, and 17 were used. In set 7, genes 69, 89, 77, 33, 71, 4, 6, 46, 72, 13, 68, 81, 31, 50, and 32 were used. In set 8, genes 29, 69, 34, 47, 32, 52, 63, 73, 23, 25, 33, 10, 37, 17, and 55 were used. In set 9, genes 24, 13, 45, 17, 51, 48, 20, 30, 29, 40, 53, 19, 88, 76, and 28 were used. In set 10, genes 86, 33, 19, 4, 84, 25, 78, 29, 88, 10, 7, 67, 85, 45, and 8 were used.
For 20 genes, set 1, genes 57, 78, 43, 50, 14, 71, 56, 25, 80, 31, 88, 4, 49, 13, 3, 38, 32, 8, 52, and 75 were used. In set 2, genes 84, 46, 23, 85, 55, 82, 56, 83, 48, 89, 8, 60, 21, 40, 20, 17, 87, 24, 34, and 39 were used. In set 3, genes 72, 88, 53, 46, 82, 9, 34, 21, 76, 24, 14, 35, 90, 31, 58, 30, 15, 41, 7, and 28 were used. In set 4, genes 22, 62, 21, 3, 45, 50, 58, 72, 69, 82, 49, 42, 47, 9, 15, 59, 17, 24, 40, and 52 were used. In set 5, genes 71, 18, 74, 53, 43, 75, 76, 54, 63, 64, 10, 5, 90, 51, 31, 58, 28, 35, 70, and 23 were used. In set 6, genes 7, 30, 77, 25, 17, 16, 35, 68, 56, 37, 78, 87, 45, 8, 42, 82, 72, 23, 58, and 54 were used. In set 7, genes 3, 58, 67, 5, 87, 62, 56, 88, 73, 50, 22, 52, 10, 60, 57, 42, 46, 26, 7, and 82 were used. In set 8, genes 63, 19, 22, 13, 82, 12, 44, 52, 8, 90, 35, 81, 79, 15, 83, 76, 51, 27, 45, and 56 were used. In set 9, genes 65, 34, 76, 81, 58, 86, 83, 46, 40, 55, 48, 42, 57, 70, 21, 72, 71, 17, 22, and 24 were used. In set 10, genes 34, 74, 2, 53, 76, 73, 19, 72, 88, 87, 44, 70, 40, 39, 22, 45, 83, 77, 30, and 46 were used.
For 25 genes, set 1, genes 13, 77, 22, 85, 58, 8, 23, 2, 40, 81, 50, 31, 14, 41, 21, 52, 6, 74, 11, 17, 83, 7, 9, 19, 18 were used. In set 2, genes 3, 12, 8, 87, 34, 75, 31, 88, 77, 39, 40, 60, 54, 9, 37, 5, 51, 53, 32, 35, 66, 4, 26, 59, and 29 were used. In set 3, genes 29, 41, 44, 56, 88, 72, 90, 6, 19, 63, 42, 24, 49, 70, 39, 17, 82, 13, 9, 4, 51, 40, 22, 71, and 25 were used. In set 4, genes 70, 82, 55, 43, 40, 32, 16, 13, 22, 41, 7, 85, 46, 42, 73, 76, 14, 60, 50, 72, 5, 81, 67, 57, and 83 were used. In set 5, genes 88, 83, 53, 26, 29, 4, 38, 71, 11, 66, 14, 89, 39, 34, 84, 41, 7, 64, 87, 3, 67, 43, 50, 79, and 6 were used. In set 6, genes 88, 16, 83, 4, 7, 39, 56, 82, 10, 20, 87, 79, 3, 35, 76, 49, 43, 11, 74, 13, 48, 22, 64, 34, and 89 were used. In set 7, genes 6, 64, 39, 50, 44, 46, 61, 28, 79, 43, 35, 85, 48, 9, 59, 47, 57, 5, 24, 33, 80, 11, 42, 20, and 26 were used. In set 8, genes 59, 24, 46, 33, 50, 71, 53, 21, 86, 10, 75, 23, 74, 60, 43, 22, 16, 62, 85, 79, 81, 34, 73, 2, and 1 were used. In set 9, genes 68, 11, 64, 54, 37, 28, 44, 73, 83, 89, 2, 41, 59, 75, 21, 23, 88, 71, 34, 29, 1, 47, 84, 60, and 72 were used. In set 10, genes 5, 12, 60, 84, 32, 58, 70, 2, 38, 42, 24, 13, 85, 10, 49, 90, 55, 81, 39, 27, 65, 56, 31, 34, and 57 were used.
For 30 genes, set 1, genes 24, 88, 10, 69, 64, 8, 19, 54, 80, 70, 11, 9, 29, 56, 36, 79, 30, 65, 2, 58, 23, 74, 41, 16, 77, 4, 78, 14, 85, and 32 were used. In set 2, genes 73, 27, 19, 52, 87, 51, 63, 4, 76, 64, 90, 81, 42, 47, 9, 62, 40, 65, 83, 30, 39, 59, 10, 11, 54, 44, 43, 6, 86, and 41 were used. In set 3, genes 28, 47, 41, 8, 24, 54, 26, 49.61, 17, 46, 64, 20, 16, 1, 33, 82, 79, 85, 5, 86, 69, 31, 65, 83, 7, 67, 35, 48, and 57 were used. In set 4, genes 13, 21, 83, 35, 47, 57, 8, 66, 75, 17, 38, 70, 39, 23, 9, 1, 2, 28, 68, 81, 36, 80, 52, 22, 44, 37, 85, 15, 72, and 86 were used. In set 5, genes 81, 20, 36, 89, 13, 14, 46, 58, 59, 62, 28, 7, 1, 25, 35, 83, 26, 50, 51, 15, 16, 56, 71, 5, 47, 6, 78, 80, 85, and 84 were used. In set 6, genes 68, 74, 73, 89, 38, 72, 33, 35, 15, 79, 3, 37, 23, 67, 10, 62, 64, 77, 44, 60, 75, 7, 51, 12, 46, 76, 81, 26, 42, and 6 were used. In set 7, genes 34, 55, 62, 40, 78, 35, 76, 30, 21, 77, 46, 71, 66, 69, 63, 81, 51, 38, 84, 53, 82, 89, 29, 14, 36, 45, 60, 7, 52, and 27 were used. In set 8, genes 56, 12, 35, 79, 57, 4, 16, 9, 24, 58, 40, 72, 80, 67, 23, 76, 88, 69, 52, 78, 32, 47, 14, 46, 64, 83, 17, 59, 81, and 20 were used. In set 9, genes 73, 27, 12, 58, 54, 62, 48, 43, 16, 41, 49, 84, 9, 75, 13, 50, 19, 3, 76, 78, 56, 68, 71, 25, 24, 60, 18, 35, 45, and 51 were used. In set 10, genes 82, 21, 24, 85, 51, 18, 72, 28, 89, 22, 34, 4, 53, 75, 83, 23, 50, 5, 42, 13, 88, 63, 40, 64, 38, 35, 39, 44, 59, and 70 were used.
For 35 genes, set 1, genes 2, 69, 70, 89, 9, 11, 5, 17, 63, 18, 12, 59, 58, 85, 26, 71, 61, 10, 3, 1, 22, 79, 84, 30, 48, 82, 38, 44, 56, 42, 88, 6, 60, 14, and 28 were used. In set 2, genes 84, 81, 88, 46, 12, 50, 38, 78, 62, 48, 19, 43, 26, 66, 4, 20, 40, 58, 9, 52, 87, 47, 6, 55, 21, 75, 31, 77, 57, 53, 45, 34, 30, 32, and 39 were used. In set 3, genes 6, 3, 22, 89, 8, 78, 87, 71, 42, 63, 18, 40, 68, 77, 64, 88, 5, 58, 43, 72, 80, 10, 21, 56, 11, 59, 61, 2, 19, 76, 30, 20, 14, 69, and 35 were used. In set 4, genes 55, 42, 89, 41, 56, 33, 24, 28, 15, 61, 63, 18, 90, 60, 35, 76, 70, 52, 8, 1, 64, 23, 13, 39, 71, 31, 3, 81, 10, 34, 66, 44, 16, 7, and 78 were used. In set 5, genes 59, 58, 12, 50, 47, 42, 28, 22, 76, 54, 1, 18, 7, 53, 68, 73, 20, 67, 14, 72, 23, 13, 39, 10, 70, 55, 45, 17, 31, 51, 80, 3, 24, 30, and 46 were used. In set 6, genes 53, 66, 26, 3, 73, 47, 61, 63, 51, 41, 29, 5, 19, 10, 57, 22, 64, 11, 34, 89, 43, 24, 31, 60, 27, 76, 17, 86, 70, 81, 50, 46, 36, 14, and 45 were used. In set 7, genes 18, 88, 90, 13, 73, 81, 64, 56, 84, 2, 4, 22, 3, 25, 35, 54, 89, 86, 27, 41, 6, 34, 38, 14, 74, 36, 59, 8, 40, 55, 42, 83, 39, 44, and 60 were used. In set 8, genes 46, 32, 22, 15, 67, 89, 14, 5, 70, 39, 49, 9, 84, 71, 12, 78, 27, 86, 26, 57, 20, 43, 58, 87, 42, 8, 31, 1, 54, 62, 69, 40, 29, 52, and 64 were used. In set 9, genes 3, 39, 55, 25, 90, 10, 9, 77, 62, 78, 18, 12, 58, 51, 22, 67, 7, 61, 59, 35, 52, 4, 65, 38, 32, 71, 87, 88, 63, 50, 73, 70, 44, 45, and 84 were used. In set 10, genes 65, 54, 51, 38, 40, 5, 43, 71, 34, 30, 22, 6, 36, 64, 63, 13, 70, 85, 21, 88, 77, 86, 79, 66, 25, 18, 26, 19, 76, 56, 23, 60, 75, 2, and 49 were used.
For 40 genes, set 1, genes 81, 80, 68, 77, 17, 71, 34, 33, 48, 88, 90, 32, 23, 2, 38, 59, 75, 82, 50, 56, 12, 36, 6, 87, 72, 37, 26, 15, 35, 66, 13, 76, 55, 3, 78, 18, 52, 47, 73, and 20 were used. In set 2, genes 11, 65, 27, 44, 88, 49, 55, 57, 1, 72, 9, 28, 56, 67, 13, 58, 42, 36, 8, 31, 40, 14, 26, 35, 62, 22, 19, 84, 78, 21, 2, 41, 74, 71, 52, 30, 25, 76, 85, and 63 were used. In set 3, genes 50, 22, 10, 54, 9, 51, 15, 34, 29, 35, 76, 89, 33, 6, 88, 56, 36, 70, 87, 40, 83, 62, 1, 42, 25, 78, 30, 26, 44, 60, 69, 47, 49, 31, 18, 59, 37, 52, 61, and 17 were used. In set 4, genes 27, 33, 7, 89, 36, 59, 48, 42, 66, 39, 90, 52, 2, 14, 30, 80, 9, 56, 21, 87, 65, 67, 41, 73, 82, 20, 4, 46, 5, 84, 88, 15, 44, 58, 78, 85, 3, 64, 6, and 8 were used. In set 5, genes 43, 24, 86, 29, 46, 90, 40, 1, 71, 57, 12, 84, 69, 19, 42, 62, 28, 35, 5, 63, 52, 17, 39, 4, 67, 81, 50, 47, 61, 54, 87, 70, 77, 6, 10, 38, 37, 79, 31, and 36 were used. In set 6, genes 28, 5, 78, 85, 16, 20, 36, 52, 43, 29, 67, 83, 12, 79, 84, 8, 81, 46, 11, 3, 54, 86, 10, 60, 71, 51, 39, 53, 59, 69, 44, 61, 7, 56, 27, 50, 66, 70, 1, and 25 were used. In set 7, genes 39, 47, 48, 24, 25, 3, 41, 16, 65, 73, 63, 14, 70, 57, 12, 64, 90, 23, 27, 38, 66, 71, 54, 21, 83, 28, 72, 53, 11, 30, 80, 15, 6, 88, 89, 85, 81, 61, 78, and 34 were used. In set 8, genes 61, 8, 57, 16, 24, 64, 48, 36, 58, 28, 27, 40, 70, 77, 25, 76, 52, 35, 62, 4, 60, 7, 54, 37, 11, 20, 72, 34, 56, 78, 10, 86, 51, 29, 84, 47, 30, 21, 59, and 67 were used. In set 9, genes 67, 3, 83, 33, 35, 26, 25, 79, 68, 19, 18, 84, 14, 58, 66, 57, 1, 2, 27, 64, 23, 24, 76, 81, 17, 37, 38, 30, 45, 75, 49, 39, 5, 53, 43, 15, 51, 40, 69, and 12 were used. In set 10, genes 39, 77, 29, 70, 85, 45, 54, 79, 31, 43, 15, 11, 47, 83, 76, 21, 67, 14, 4, 19, 49, 42, 18, 13, 12, 7, 88, 8, 3, 35, 81, 55, 71, 60, 72, 57, 46, 40, 56, and 32 were used.
For 45 genes, set 1, genes 7, 63, 45, 87, 19, 55, 36, 42, 9, 4, 79, 68, 46, 35, 40, 80, 59, 58, 38, 17, 50, 30, 13, 39, 33, 84, 34, 64, 2, 57, 24, 88, 65, 16, 53, 18, 28, 8, 60, 15, 43, 73, 77, 20, and 78 were used. In set 2, genes 70, 19, 81, 68, 38, 35, 48, 9, 53, 11, 73, 42, 54, 28, 32, 40, 60, 88, 25, 7, 67, 17, 36, 51, 44, 46, 10, 89, 14, 80, 39, 41, 27, 8, 75, 47, 61, 57, 59, 76, 86, 65, 63, 74, and 77 were used. In set 3, genes 55, 24, 63, 17, 32, 81, 2, 67, 51, 85, 27, 46, 60, 90, 25, 35, 58, 11, 47, 33, 73, 3, 74, 52, 15, 86, 6, 78, 36, 66, 57, 13, 49, 28, 75, 70, 4, 77, 43, 26, 61, 64, 20, 1, and 23 were used. In set 4, genes 49, 72, 13, 51, 55, 11, 29, 5, 43, 44, 40, 6, 38, 67, 47, 35, 36, 28, 81, 24, 80, 32, 16, 88, 63, 87, 86, 79, 21, 1, 30, 10, 62, 58, 23, 12, 78, 26, 69, 56, 85, 42, 17, 84, and 39 were used. In set 5, genes 53, 33, 18, 65, 22, 83, 50, 88, 76, 40, 82, 68, 85, 5, 63, 45, 78, 16, 42, 54, 27, 66, 70, 74, 7, 51, 89, 64, 49, 37, 84, 86, 34, 39, 80, 31, 61, 87, 69, 4, 81, 30, 14, 41, and 29 were used. In set 6, genes 7, 60, 38, 14, 73, 9, 79, 81, 22, 10, 85, 51, 40, 87, 3, 26, 57, 56, 12, 72, 39, 59, 63, 28, 64, 71, 69, 21, 67, 48, 50, 66, 46, 88, 11, 13, 24, 8, 58, 75, 2, 41, 5, 44, and 55 were used. In set 7, genes 15, 65, 31, 19, 11, 38, 2, 9, 64, 66, 22, 35, 49, 3, 77, 43, 32, 56, 39, 54, 80, 21, 6, 40, 27, 86, 10, 16, 70, 30, 85, 23, 26, 4, 55, 73, 42, 13, 41, 68, 29, 57, 28, 72, and 58 were used. In set 8, genes 83, 27, 9, 62, 84, 78, 13, 5, 74, 55, 12, 34, 58, 3, 67, 57, 24, 45, 42, 47, 75, 25, 29, 44, 46, 61, 56, 70, 86, 37, 14, 49, 60, 89, 28, 72, 59, 38, 2, 81, 50, 7, 6, 21, and 82 were used. In set 9, genes 7, 10, 35, 14, 79, 66, 33, 52, 16, 55, 68, 59, 57, 19, 11, 47, 22, 38, 61, 30, 71, 50, 63, 88, 53, 80, 6, 54, 77, 21, 37, 84, 9, 65, 12, 49, 40, 73, 76, 2, 28, 29, 3, 72, and 18 were used. In set 10, genes 12, 19, 9, 80, 84, 15, 7, 2, 39, 21, 48, 40, 51, 69, 74, 83, 5, 66, 27, 26, 89, 60, 4, 86, 41, 44, 35, 10, 76, 53, 63, 16, 37, 79, 11, 42, 68, 3, 59, 82, 77, 73, 85, 67, and 14 were used.
For 49 genes, set 1, genes 84, 47, 56, 1, 18, 21, 57, 54, 27, 89, 44, 85, 64, 10, 77, 34, 65, 66, 80, 70, 46, 23, 53, 61, 24, 81, 43, 35, 30, 74, 83, 51, 20, 17, 72, 4, 49, 68, 60, 28, 67, 19, 42, 55, 73, 36, 7, 39, and 33 were used. In set 2, genes 47, 29, 58, 36, 21, 53, 40, 7, 83, 77, 24, 89, 71, 64, 60, 4, 37, 86, 27, 57, 62, 63, 72, 1, 88, 78, 68, 17, 51, 16, 82, 42, 81, 18, 32, 49, 55, 10, 11, 66, 35, 23, 70, 20, 61, 25, 48, 43, and 54 were used. In set 3, genes 54, 2, 62, 67, 44, 25, 8, 53, 86, 33, 75, 32, 45, 76, 43, 65, 59, 58, 42, 64, 47, 78, 3, 57, 71, 88, 14, 23, 51, 83, 1, 41, 7, 56, 40, 20, 39, 72, 70, 19, 5, 35, 50, 82, 37, 48, 15, 31, and 16 were used. In set 4, genes 35, 65, 48, 43, 69, 62, 64, 74, 82, 39, 37, 1, 88, 45, 66, 12, 79, 55, 38, 84, 17, 30, 25, 26, 89, 56, 28, 57, 59, 34, 85, 14, 47, 44, 41, 19, 60, 20, 73, 2, 63, 75, 49, 80, 58, 77, 27, 54, and 29 were used. In set 5, genes 64, 51, 36, 12, 84, 24, 65, 47, 88, 26, 10, 19, 73, 90, 35, 53, 18, 55, 80, 70, 79, 82, 87, 77, 15, 85, 83, 7, 72, 1, 6, 57, 38, 45, 74, 33, 62, 86, 31, 69, 27, 14, 4, 29, 54, 44, 63, 78, and 42 were used. In set 6, genes 24, 39, 85, 42, 88, 32, 65, 23, 6, 75, 53, 77, 64, 90, 13, 82, 47, 31, 48, 8, 78, 67, 63, 44, 26, 40, 14, 34, 18, 59, 2, 17, 20, 56, 83, 68, 86, 9, 38, 73, 89, 55, 29, 69, 72, 16, 28, 51, and 81 were used. In set 7, genes 32, 70, 57, 67, 1, 73, 52, 38, 65, 83, 5, 40, 49, 31, 66, 85, 6, 82, 12, 48, 89, 3, 19, 41, 62, 16, 46, 61, 24, 18, 55, 30, 33, 56, 68, 20, 81, 10, 86, 9, 15, 63, 78, 22, 75, 14, 13, 43, and 77 were used. In set 8, genes 17, 30, 47, 85, 7, 3, 6, 35, 76, 77, 25, 86, 36, 75, 44, 29, 69, 60, 63, 64, 82, 51, 19, 68, 41, 28, 73, 18, 10, 26, 42, 78, 67, 12, 80, 33, 13, 57, 38, 87, 49, 59, 74, 50, 90, 46, 8, 81, and 4 were used. In set 9, genes 20, 76, 42, 36, 66, 21, 8, 28, 22, 15, 56, 5, 2, 86, 17, 62, 23, 1, 80, 73, 52, 83, 32, 65, 44, 82, 35, 60, 47, 90, 74, 9, 84, 50, 4, 77, 55, 57, 19, 71, 25, 48, 81, 53, 34, 38, 3, 37, and 16 were used. In set 10, genes 84, 87, 3, 41, 36, 71, 33, 57, 85, 26, 53, 22, 82, 31, 2, 45, 24, 18, 37, 35, 77, 20, 63, 25, 6, 17, 58, 7, 9, 49, 28, 76, 79, 67, 13, 80, 66, 5, 43, 4, 74, 75, 21, 86, 23, 39, 42, 27, and 54 were used.

Example 5: PCR Based Detection

As noted above, the determination or measurement of gene expression may be performed by PCR, such as the use of quantitative PCR. Detecting expression of about 5 to 49 expressed sequences in the human genome may be used in such embodiments of the invention. Additionally, expression levels of about 5 to 49 gene sequences in the set of 74, the set of 90, or a combination set of the two (with a total of 126 gene sequences given the presence of 38 gene sequences in common between the two sets) may also be used. The invention contemplates the use of quantitative PCR to measure expression levels, as described above, of about 5 to 49 of 87 gene sequences, all of which are present in either the set of 74 or the set of 90. Of the 87 gene sequences, 60 are present in the set of 74, and 63 are present in the set of 90. The identifiers/accession numbers of the 87 gene sequences are AA456140, AA745593, AA765597, AA782845, AA865917, AA946776, AA993639, AB038160, AF104032, AF133587, AF301598, AF332224, AI041545, AI147926, AI309080, AI341378, AI457360, AI620495, AI632869, AI683181, AI685931, AI802118, AI804745, AI952953, AI985118, AJ000388, AK025181, AK027147, AK054605, AL023657, AL039118, AL110274, AL157475, AW118445, AW194680, AW291189, AW298545, AW445220, AW473119, AY033998, BC000045, BC001293, BC001504, BC001639, BC002551, BC004331, BC004453, BC005364, BC006537, BC006811, BC006819, BC008764, BC008765, BC009084, BC009237, BC010626, BC011949, BC012926, BC013117, BC015754, BC017586, BE552004, BE962007, BF224381, BF437393, BF446419, BF592799, BI493248, H05388, H07885, H09748, M95585, N64339, NM_000065, NM_001337, NM_003914, NM_004062, NM_004063, NM_004496, NM_006115, NM_019894, NM_033229, R15881, R45389, R61469, X69699, and X96757.
The use of from about 5 to 49 of these sequences in the practice of the invention may include the use of expression levels measured for reference gene sequences as described herein. In some embodiments, the reference gene sequences are one or more of the 8 disclosed herein. The invention contemplates the use of one or more of the reference sequences identified by AF308803, AL137727, BC003043, BC006091, and BC016680 in PCR or QPCR based embodiments of the invention. Of course all 5 of these reference sequences may also be used in combination.

Example 6: mRNA Sequences (Sequence Listing)

>Hs.73995_mRNA_1 gi\|190403\|gb\|M60502.1 HUMPROFILE Human profilaggrin mRNA
3′ end polyA = 1
GGCCACTCTGCAGACAGCTCCAGACAATCAGGCACTCGTCACACAGAGTCTTCCTCTCGT

GGACAGGCTGCGTCATCCCATGAACAGGCAAGATCAAGTGCAGGAGAAAGACATGGATCC

CACCACCAGCAGTCAGCAGACAGCTCCAGACACGCAGGCATTGGGCACGGACAAGCTTCA

TCTGCAGTCAGAGACAGTGGACACCGAGGGTACAGAGGTAGTCAGGCCACTGACAGTGAG

GGACATTCAGAAGACTCAGACACACAGTCAGTGTCAGCACAGGGACAAGCTGGGCCCCAT

CAGCAGAGCCACCAAGAGTCCGCACGTGGCCAGTCAGGGGAAAGCTCTGGACGTTCAGGG

TCTTTCCTCTACCAGGTGAGCACTCATGAACAGTCTGAGTCCACCCATGGACAGTCTGTG

CCCAGCACTGGAGGAAGACAAGGATCCCACCATGATCAGGCACAAGACAGCTCCAGGCAC

TCAGCATCCCAAGAGGGTCAGGACACCATTCGTGGACACCCGGGGCCAAGCAGAGGAGGA

AGACAGGGGTCCCACCACGAGCAATCGGTAGATAGGTCTGGACACTCAGGGTCCCATCAC

AGCCACACCACATCCCAGGGAAGGTCTGATGCCTCCCGTGGGCAGTCAGGATCCAGAAGT

GCAAGCAGACAAACACATGACCAGGAACAATCAGGAGACGGCTCTAGGCACTCAGGGTCG

CGTCATCAGGAAGCTTCCTCTTGGGCCGACAGCTCTAGACACTCACAGGCAGTCCAGGGA

CAATCAGAGGGGTCCAGGACAAGCAGGCGCCAGGGATCCAGTGTTAGCCAGGACAGTGAC

AGTCAGGGACACTCAGAAGACTCTGAGAGGCGGTCTGGGTCTGCTTCCAGAAACCATCGT

GGATCTGCTCAGGAGCAGTCAAGAGATGGCTCCAGACACCCCAGGTCCCATCACGAAGAC

AGAGCCGGTCACGGGGACTCTGCAGAGAGCTCCAGACAATCAGGCACTCATCATGCAGAG

AATTCCTCTGGTGGACAGGCTGCATCATCCCATGAACAGGCAAGATCAAGTGCAGGAGAG

AGACATGGATCCCACTACCAGCAGTCAGCAGACAGCTCCAGACACTCAGGCATTGGGCAC

GGACAAGCTTCATCTGCAGTCAGAGACAGTGGACACCGAGGGTCCAGTGGTAGTCAGGCC

AGTGACAATGAGGGACATTCAGAAGACTCAGACACACAGTCAGTGTCAGCCCACCGACAG

GCTGGGCGCCATCACGAGAGCCACCAAGAGTCCACACGTGGCCGGTCACGAGGAAGGTCT

GGACGTTCAGGGTCTTTCCTCTACCAGGTGAGCACTCATGAACAGTCTGAGTCTGCCCAT

GGACGGGCTGGGCCCAGTACTGGAGGAAGACAAGGATCCCGCCACGAGCAGGCACGAGAC

AGCTCCAGGCACTCAGCGTCCCAAGAGGGTCAGGACACCATTCGTGGACACCCGGGGTCA

AGGAGAGGAGGAAGACAGGGATCCTACCACGAGCAATCGGTAGATAGGTCTGGACACTCA

GGGTCCCATCACAGCCACACCACATCCCAGGGAAGGTCTGATGCCTCCCATGGGCAGTCA

GGATCCAGAAGTGCAAGCAGAGAAACACGTAATGAGGAACAGTCAGGAGACGGCTCCAGG

CACTCAGGGTCGCGTCACCATGAAGCTTCCACTCAGGCTGACAGCTCTAGACACTCACAG

TCCGGCCAGGGTGAATCAGCGGGGTCCAGGAGAAGCAGGCGCCAGGGATCCAGTGTTAGC

CAGGACAGTGACAGTGAGGCATACCCAGAGGACTCTGAGAGGCGATCTGAGTCTGCTTCC

AGAAACCATCATGGATCTTCTCGGGAGCAGTCAAGAGATGGCTCCAGACACCCCGGATCC

TCTCACCGCGATACAGCCAGTCATGTACAGTCTTCACCTGTACAGTCAGACTCTAGTACC

GCTAAGGAACATGGTCACTTTAGTAGTCTTTCACAAGATTCTGCGTATCACTCAGGAATA

CAGTCACGTGGCAGTCCTCACAGTTCTAGTTCTTATCATTATCAATCTGAGGGCACTGAA

AGGCAAAAAGGTCAATCAGGTTTAGTTTGGAGACATGGCAGCTATGGTAGTGCAGATTAT

GATTATGGTGAATCCGGGTTTAGACACTCTCAGCACGGAAGTGTTAGTTACAATTCCAAT

CCTGTTCTTTTCAAGGAAAGATCTGATATCTGTAAAGCAAGTGCGTTTGGTAAAGATCAT

CCAAGGTATTATGCAACGTATATTAATAAGGACCCAGGTTTATGTGGCCATTCTAGTGAT

ATATCGAAACAACTGGGATTTAGTCAGTCACAGAGATACTATTACTATGAGTAAGAAATT

AATGGCAAAGGAATTAATCCAAGAATAGAAGAATGAAGCAAGTTCACTTTCAATCAAGAA

ACTTCATAATACTTTCAGGGAAGTTATCTTTTCCTGTCAATCTGTTTAAAATATGCTATA

GTATTTCATTAGTTTGGTGGTAACTTATTTTTATTGTGTAATGATCTTTAAACGCTATAT

TTCAGAAATATTAAATGGAAGAAATCAATATCATGGAGAGCTAACTTTAGAAAACTAGCT

GGAGTATTTTAGGAGATTCTGGGTCAAGTAATGTTTTATGTTTTTGAAAGTTTAAGTTTT

AGACACTCCCCAAATTTCTAAATTAATCTTTTTCAGAAATATCGAAGGAGCCAAAAATAT

AAAACAGTTCTGATATCCAAAGTGGCTATATCAACATCAGGGCTAGCACATCTTTCTCTA

TTATCCTTCTATTGGAATTCTAGTATTCTGTATTCAAAAAATCATCTTGGACATAATTAA

TATTTTAGTAAGCTGCATCTAAATTAAAAATAAACTATTCATCATATAAT

>Hs.75236_mRNA_4 gi\|14280328\|gb\|AY033998.1\|Homo sapiens polyA = 3
TAGAATCGGGGGTTTCAGCTCACTGCTCCTTTTCTTTTTTTTCTTTCTCTCCCCCGCCCA

CCCCCCCAAAAATAATTGATTTGCTTTACAATCATCCACACTGTGTTTTGTGGATCTTTA

ATTATATATAACAATAGTAGTCATTTTAAATATATATTCTGAAATCTTTGCAAATTTTAA

CAGAAGAGTCGAAGCTCTGCGAGACCCAATATTTGCCAATAAGAATGGTTATGATAATTA

GCACCATGGAGCCTCAGGTGTCAAATGGTCCGACATCCAATACAAGCAATGGACCCTCCA

GCAACAACAGAAACTGTCCTTCTCCCATGCAAACAGGGGCAACCACAGATGACAGCAAAA

CCAACCTCATCGTCAACTATTTACCCCAGAATATGACCCAAGAAGAATTCAGGAGTCTCT

TCGGGAGCATTGGTGAAATAGAATCCTGCAAACTTGTGAGAGACAAAATTACAGGACAGA

GTTTAGGGTATGGATTTGTTAACTATATTGATCCAAAGGATGCAGAGAAAGCCATCAACA

CTTTAAATGGACTCAGACTCCAGACCAAAACCATAAAGGTCTCATATGCCCGTCCGAGCT

CTGCCTCAATCAGGGATGCTAACCTCTATGTTAGCGGCCTTCCCAAAACCATGACCCAGA

AGGAACTGGAGCAACTTTTCTCGCAATACGGCCGTATCATCACCTCACGAATCCTGGTTG

ATCAAGTCACAGGAGTGTCCAGAGGGGTGGGATTCATCCGCTTTGATAAGAGGATTGAGG

CAGAAGAAGCCATCAAAGGGCTGAATGGCCAGAAGCCCAGCGGTGCTACGGAACCGATTA

CTGTGAAGTTTGCCAACAACCCCAGCCAGAAGTCCAGCCAGGCCCTGCTCTCCCAGCTCT

ACCAGTCCCCTAACCGGCGCTACCCAGGTCCACTTCACCACCAGGCTCAGAGGTTCAGGC

TGGACAATTTGCTTAATATGGCCTATGGCGTAAAGAGACTGATGTCTGGACCAGTCCCCC

CTTCTGCTTGTTCCCCCAGGTTCTCCCCAATTACCATTGATGGAATGACAAGCCTTGTGG

GAATGAACATCCCTGGTCACACAGGAACTGGGTGGTGCATCTTTGTCTACAACCTGTCCC

CCGATTCCGATGAGAGTGTCCTCTGGCAGCTCTTTGGCCCCTTTGGAGCAGTGAACAACG

TAAAGGTGATTCGTGACTTCAACACCAACAAGTGCAAGGGATTCGGCTTTGTCACCATGA

CCAACTATGATGAGGCGGCCATGGCCATCGCCAGCCTCAACGGGTACCGCCTGGGAGACA

GAGTGTTGCAAGTTTCCTTTAAAACCAACAAAGCCCACAAGTCCTGAATTTCCCATTCTT

ACTTACTAAAATATATATAGAAATATATACGAACAAAACACACGCGCGCACACACACACA

TACACGAAAGAGAGAGAAACAAACTTTTCAAGGCTTATATTCAACCATGGACTTTATAAG

CCAGTGTTGCCTAAGTATTAAAACATTGGATTATCCTGAGGTGTACCAGGAAAGGATTTT

ATAATGCTTAGAAAAAAAAAAAAAAAAAAAA

>Hs.299867_mRNA_1 gi\|4758533\|ref\|NM_004496.1 Homo sapiens hepatocyte
nuclear factor 3, alpha (HNF3A), mRNA polyA = 3
TCCAGGAATCGATAGTGCATTCGTGCGCGCGGCCGCCCGTCGCTTCGCACAGGGCTGGAT

GGTTGTATTGGGCAGGGTGGCTCCAGGATGTTAGGAACTGTGAAGATGGAAGGGCATGAA

ACCAGCGACTGGAACAGCTACTACGCAGACACGCAGGAGGCCTACTCCTCGGTCCCGGTC

AGCAACATGAACTCAGGCCTGGGCTCCATGAACTCCATGAACACCTACATGACCATGAAC

ACCATGACTACGAGCGGCAACATGACCCCGGCGTCCTTCAACATGTCCTATGCCAACCCG

GCCTTAGGGGCCGGCCTGAGTCCCGGCGCAGTAGCCGGCATGCCGGGGGGCTCGGCGGGC

GCCATGAACAGCATGACTGCGGCCGGCGTGACGGCCATGGGTACGGCGCTGAGCCCGAGC

GGCATGGGCGCCATGGGTGCGCAGCAGGCGGCCTCCATGATGAATGGCCTGGGCCCCTAC

GCGGCCGCCATGAACCCGTGCATGAGCCCCATGGCGTACGCGCCGTCCAACCTGGGCCGC

AGCCGCGCGGGCGGCGGCGGCGACGCCAAGACGTTCAAGCGCAGTTACCCGCACGCCAAG

CCGCCCTACTCGTACATCTCGCTCATCACCATGGCCATCCAGCGGGCGCCCAGCAAGATG

CTCACGCTGAGCGAGATCTACCAGTGGATCATGGACCTCTTCCCCTATTACCGGCAGAAC

CAGCAGCGCTGGCAGAACTCCATCCGCCACTCGCTGTCCTTCAATGACTGCTTCGTCAAG

GTGGCACGCTCCCCGGACAAGCCGGGCAAGGGCTCCTACTGGACGCTGCACCCGGACTCC

GGCAACATGTTCGAGAACGGCTGCTACTTGCGCCGCCAGAAGCGCTTCAAGTGCGAGAAG

CAGCCGGGGGCCGGCGGCGGGGGCGGGAGCGGAAGCGGGGGCAGCGGCGCCAAGGGCGGC

CCTGAGAGCCGCAAGGACCCCTCTGGCGCCTCTAACCCCAGCGCCGACTCGCCCCTCCAT

CGGGGTGTGCACGGGAAGACCGGCCAGCTAGAGGGCGCGCCGGCCCCGGGCCCGGCCGCC

AGCCCCCAGACTCTGGACCACAGTGGGGCGACGGCGACAGGGGGCGCCTCGGAGTTGAAG

ACTCCAGCCTCCTCAACTGCGCCCCCCATAAGCTCCGGGCCCGGGGCGCTGGCCTCTGTG

CCCGCCTCTCACCCGGCACACGGCTTGGCACCCCACGAGTCCCAGCTGCACCTGAAAGGG

GACCCCCACTACTCCTTCAACCACCCGTTCTCCATCAACAACCTCATGTCCTCCTCGGAG

CAGCAGCATAAGCTGGACTTCAAGGCATACGAACAGGCACTGCAATACTCGCCTTACGGC

TCTACGTTGCCCGCCAGCCTGCCTCTAGGCAGCGCCTCGGTGACCACCAGGAGCCCCATC

GAGCCCTCAGCCCTGGAGCCGGCGTACTACCAAGGTGTGTATTCCAGACCCGTCCTAAAC

ACTTCCTAGCTCCCGGGACTGGGGGGTTTGTCTGGCATAGCCATGCTGGTAGCAAGAGAG

AAAAAATCAACAGCAAACAAAACCACACAAACCAAACCGTCAACAGCATAATAAAATCCA

ACAACTATTTTTATTTCATTTTTCATGCACAACCTTGCCCCCAGTGCAAAAGACTGTTAC

TTTATTATTGTATTCAAAATTCATTGTGTATATTACTACAAAGACGGCCCCAAACCAATT

TTTTTCCTGCGAAGTTTAATGATCCACAAGTGTATATATGAAATTCTCCTCCTTCCTTGC

CCCCCTCTCTTTCTTCCCTCTTGGCCCTCCAGACATTCTAGTTTGTGGAGGGTTATTTAA

AAAACAAAAAGGAAGATGGTCAAGTTTGTAAAATATTTGTTTGTGCTTTTCCCCCCTCCT

TACCTGACCCCCTACGAGTTTACAGGCTTGTGGCAATACTCTTAACCATAAGAATTGAAA

TGGTGAAGAAACAAGTATACACTAGAGGCTCTTAAAAGTATTGAAAAGACAATACTGCTG

TTATATAGCAAGACATAAACAGATTATAAACATCAGAGCCATTTGCTTCTCAGTTTACAT

TTCTGATACATGCAGATAGCAGATGTCTTTAAATGAAATACATGTATATTGTGTATGGAC

TTAATTATGCACATGCTCAGATGTGTAGACATCCTCCGTATATTTACATAACATATAGAG

GTAATAGATAGGTGATATACGTGATACGTTCTCAAGAGTTGCTTGACCGAAAGTTACAAG

GACCCCAACCCCTTTGCTCTCTACCCACAGATGGCCCTGGGAACAATCCTCAGGAATTGC

CCTCAAGAACTCGCTTCTTTGCTTTGAGAGTGCCATGGTCATGTCATTCTGAGGTACATA

ACACATAAATTAGTTTCTATGAGTGTATACCATTTAAAGATTTTTTCAGTAAAGGGAATA

TTACATGTTGGGAGGAGGAGATAAGTTATAGGGAGCTGGATTTCAAACGGTGGTCCAAGA

TTCAAAAATCCTATTGATAGTGGCCATTTTAATCATTGCCATCGTGTGCTTGTTTCATCC

AGTGTTATGCACTTTCCACAGTTGGTGTTAGTATAGCCAGAGGGTTTCATTATTATTTCT

CTTTGCTTTCTCAATGTTAATTTATTGCATGGTTTATTCTTTTTCTTTACAGCTGAAATT

GCTTTAAATGATGGTTAAAATTACAAATTAAATTGGGAATTTTTATCAATGTGATTGTAA

TTAAAAATATTTTGATTTAAATAACAAAAATAATACCAGATTTTAAGCCGCGGAAAATGT

TCTTGATCATTTGCAGTTAAGGACTTTAAATAAATCAAATGTTAACAAAAAA

>Hs.285401_contig1
AI147926\|AI880620\|AA768316\|AA761543\|AA279147\|AI216016\|AI738663\|N79248\|AI684
489\|AA960845\|AI718599\|AI379138\|N29366\|BF002507\|AW044269\|R34339\|R66326\|H0464
8\|R67467\|AI523112\|BF941500 polyA = 2 polyA = 3
TGTTTTTCTAGTTCATTTTGTGTTTCCAACTTTTCATGTAAAATTTTAATTATTTTTGAA

TGTGTGGATGTGAGACTGAGGTGCCTTTTGGTACTGAAATTCTTTTTCCATGTACCTGAA

GTGTTACTTTTGTGATATAGGAAATCCTTGTATATATACTTTATTGGTCCCTAGGCTTCC

TATTTTGTTACCTTGCTTTCTCTATGGCATCCACCATTTTGATTGTTCTACTTTTATGAT

ATGTTTTCATAAGTGGTTAAGCAAGTATTCTCGTTACTTTTGCTCTTAAATCCCTATTCA

TTACAGCAATGTTGGTGGTCAAAGAAAATGATAAACAACTTGAATGTTCAATGGTCCTGA

AATACATAACAACATTTTAGTACATTGTAAAGTAGAATCCTCTGTTCATAATGAACAAGA

TGAACCAATGTGGATTAGAAAGAAGTCCGAGATATTAATTCCAAAATATCCAGACATTGT

TAAAGGGAAAAAATTGCAATAAAATATTTGTAACATAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.182507_mRNA_1 gi\|15431324\|ref\|NM_002283.2\|Homo sapiens keratin, hair,
basic, 5 (KRTHB5), mRNA polyA = 3
AGCTCTCCCCACCAATAAAAGGACCAGGGAGGATCAGAGAGAGCAGAAGGATCCTGAGCC

TCGCACTCTGCCGCCCGCACCACCTTCCGCTGCCTCTCAGACTCTGCTCAGCCTCACACG

ATGTCGTGCCGCTCCTACAGGATCAGCTCAGGATGCGGGGTCACCAGGAACTTCAGCTCC

TGCTCAGCTGTGGCCCCCAAAACTGGCAACCGCTGCTGCATCAGCGCCGCCCCCTACCGA

GGGGTGTCCTGCTACCGAGGGCTGACGGGCTTCGGCAGCCGCAGCCTCTGCAACCTGGGC

TCCTGCGGGCCCCGGATAGCTGTAGGTGGCTTCCGAGCCGGCTCCTGCGGACGCAGCTTC

GGCTACCGCTCCGGGGGCGTGTGCGGACCCAGCCCCCCATGCATCACTACCGTGTCGGTC

AACGAGAGCCTCCTCACGCCCCTCAACCTGGAGATCGACCCCAACGCACAGTGCGTGAAG

CAGGAGGAGAAGGAGCAGATCAAGTCCCTCAACAGCAGGTTCGCGGCCTTCATCGACAAG

GTGCGCTTCCTGGAGCAGCAGAACAAGCTGCTGGAGACCAAGTGGCAGTTCTACCAGAAC

CAGCGCTGCTGCGAGAGCAACCTGGAGCCACTGTTCAGTGGCTACATCGAGACTCTGCGG

CGGGAGGCCGAGTGCGTGGAGGCCGACAGCGGGAGGCTGGCCTCAGAGCTCAACCATGTG

CAGGAGGTGCTGGAGGGCTACAAGAAGAAGTATGAAGAGGAGGTGGCCCTGAGAGCCACA

GCAGAGAATGAGTTTGTCGTTCTAAAGAAGGACGTGGACTGTGCCTACCTGCGGAAATCA

GACCTGGAGGCCAATGTGGAGGCCCTGGTGGAGGAGTCTAGCTTCCTGAGGCGCCTCTAT

GAAGAGGAGATCCGCGTTCTCCAAGCCCACATCTCAGACACCTCGGTCATAGTCAAGATG

GACAACAGCCGAGACCTGAACATGGACTGCATCATCGCTGAGATCAAGGCTCAGTATGAC

GATGTTGCCAGCCGCAGCCGGGCCGAGGCTGAGTCCTGGTACCGTAGCAAGTGTGAGGAG

ATGAAGGCCACGGTGATCAGGCATGGGGAGACCCTGCGCCGCACCAAGGAGGAGATCAAC

GAGCTGAACCGCATGATCCAGAGGCTGACGGCCGAGATTGAGAATGCCAAGTGCCAGCGT

GCCAAGCTGGAGGCTGCTGTGGCTGAGGCAGAGCAGCAGGGTGAGGCGGCCCTCAGCGAT

GCCCGCTGCAAGCTGGCTGAGCTGGAGGGCGCCCTGCAGAAGGCCAAGCAGGACATGGCC

TGCCTGCTCAAGGAGTACCAGGAGGTGATGAACTCCAAGCTGGGCCTGGACATCGAGATC

GCCACCTACAGGCGCCTGCTGGAGGGCGAGGAACACAGGCTGTGTGAAGGTGTGGGCTCT

GTGAATGTCTGTGTCAGCAGCTCCCGTGGTGGAGTCTCCTGTGGGGGCCTCTCCTACAGC

ACCACCCCAGGGCGCCAGATCACTTCTGGCCCCTCAGCCATAGGCGGCAGCATCACGGTG

GTGGCCCCTGACTCCTGTGCCCCCTGCCAGCCTCGTTCCTCCAGCTTCAGCTGCGGGAGT

AGCCGGTCGGTCCGCTTTGCCTAGTAGAGTCATGGAGCCAGGGCTTCCTGCCAAGCACCT

GCCTGCCTGCATCACTGCACTGAATGGCATGTGAATGGAAAATGTGTGCTTGCTTCCAGA

ATCTTCTGGATGTTCCTACAGAGGGAAAGACCTACAGAGGGAAAGACCCTCGGGCCGCTC

CCCTGCGCCTTTTCATGCTAGGGAGATGCATCCTAGTTGTCCTCCTGGCAGCTGTTTTCA

GAGGCATTCCCAGCCCTTCACTTAACTCCTACTTAGCTCCAAAATACCTGTATCCAATTT

GTATTATTCCCCCAGCTCTCAGGGACAAGACCAGTCCCCCAGCGTGGTGGTCAGCACGGA

AGCTCCACCTTCTGGGTGGAGGCGCCATCCTAACCATCCAGCCAGGCCACCCACAACCCG

AGAATCAGGGAGAAAGTCCCTCCCCAGCAGCCCCCTCCTCCTGGCTGGGAAGAATGGTCC

CCCAGCAAGCACTTGCCTGTTCATTCCCGTTCATGTTTTGCTTCTCTCTCAGACTGCCTT

CCTGCTTCTGGGCTAACCTGTTCCAGCCAGGCTCCTCATGTGACCTCGCAGTTGAGAAGC

CCATTATCGTGGGGCATCCTTTTGCCTACAGCCCCTGGTTAGGGCACTTTGGACAGGTCT

TGCTATTCAGTGAACCTTTGTACATTTCAAAGAAGACTCCATGGCTGCTCCAGATGCCCC

CTTGCTGGGTGCAGGTGGGGACTGTCCAATGCAGAGCTGGCGGGACAGAGAGTTAAGCCA

CTTCCTGGGTCTCCTTCTTATGACTGTCTATGGGTGCATTGCCTTCTGGGTTGTCTCGAT

CTGTGTTTCAATAAATGCCGCTGCAATGCAAAAAAAAAAAAAAAAAAA

>Hs.292653_contig1
AI200660\|AW014007\|AI341199\|AI692279\|AI393765\|AI378686\|AI695373\|AW292108\|T10
352\|R44346\|AW470408\|AI380925\|BF938983\|AW003704\|H08077\|F03856\|H08075\|F08895\|
AW468398\|AI865976\|H22568\|AI858374\|AI216499 polyA = 2 polyA = 3
CAATCAGTGAAAATTCTATATTCCTTTGGCATTTTTGTGACATATTCAATTCAGTTNTAT

GTTCCAGCAGAGATCATTATCCCTGGGATCACATCCAAATTTCATACTAAATGGAAGCAA

ATCTGTGAATTTGGGATAAGATCCTTCTTGGTTAGTATTACTTGCGCCGGAGCAATGTCT

TATTCCTCGTTTAGACATTGTGATTTCCTTCGTTGGAGCTGTGAGCAGCAGCACATTGGC

CCTAATCCTGCCACCTTTGGTTGAAATTCTTACATTTTCGAAGGAACATTATAATATATG

GATGGTCCTGAAAAATATTTCTATAGCATTCACTGGAGTTGTTGGCTTCTTATTAGGTAC

ATATATAACTGTTGAAGAAATTATTTATCCTACTCCCAAAGTTGTAGCTGGCACTCCACA

GAGTCCTTTTCTAAATTTGAATTCAACATGCTTAACATCTGGTTTGAAATAGTAAAAGCA

GAATCATGAGTCTTCTATTTTTGTCCCATTTCTGAAAATTATCAAGATAACTAGTAAAAT

ACATTGCTATATACATAAAAATGGTAACAAACTCTGTTTTCTTTGGCACGATATTAATAT

TTTGGAAGTAATCATAACTCTTTACCAGTAGTGGTAAACCTATGAAAAATCCTTGCTTTT

AAGTGTTAGCAATAGTTCAAAAAATTAAGTTCTGAAAATTGAAAAAATTAAAATGTAAAA

AAATTAAAGAATAAAAATACTTCTATTATTCTTTTATCTCAGTAAGAAATACCTTAACCA

AGATATCTCTCTTTTATGCTACTCTTTTGCCACTCACTTGAGAACAGAATAGGATTTCAA

CAATAAGAGAATAAAATAAGAACATGTATAACAAAAAGCTCTCTCCAGATCATCCCTGTG

AATGCCAAAGTAAACTTTATGTACAGTGTAAAAAAAAAAAAATCTCAGTTATGTTTTTAT

TAGCCAAATTCTAATGATTGGCTCCTGGAAGTATAGAAAACTCCCATTAACATAATATAA

GCATCAGAAAATTGCAAACACTAGAATTAATTTTACACTCTAATGGTAGTTGATCTTCAT

AGTCAAGAGGCACTGTTCAAGATCATGACTTAGTGTTTCAATGAAATTTGAAAAGGGACT

TTAAAACTTATCCAGTGCAACTCCCTTGTTTTTCGTCAGAGGAAAAGGAGGCCTAGAAAG

GTTAAGTAACTTGGTCGAGACCACTCAGCCTTGAGATCAAGAAAACCTAATCTTCTGACT

CCCAGGCCAGGATGTTTTATTTCTCACATCATGTCCAAGAAAAAGAATAAATTATGTTCA

GCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.97616_mRNA_3 gi\|12654852\|gb\|BC001270.1\|BC001270 Homo sapiens clone
MGC:5069 IMAGE:3458016 polyA = 3
CGGAGGCGGCGCCGACGGGGACTGCTGAGGCGCGCAGAGGGTCGGCGGCGCCCGGGAGCC

TGTCGCTGGCGCGGTCCGGGCGGGAGGCTCGGCGGCGGGCGGCAGCATGTCGGTGGCGGG

GCTGAAGAAGCAGTTCTACAAGGCGAGCCAGCTGGTCAGTGAGAAGGTCGGAGGGGCCGA

GGGGACCAAGCTGGATGATGACTTCAAAGAGATGGAGAAGAAGGTGGATGTCACCAGCAA

GGCGGTGACAGAAGTGCTGGCCAGGACCATCGAGTACCTGCAGCCCAACCCAGCCTCGCG

GGCTAAGCTGACCATGCTCAACACGGTGTCCAAGATCCGGGGCCAGGTGAAGAACCCCGG

CTACCCGCAGTCGGAGGGGCTTCTGGGCGAGTGCATGATCCGCCACGGGAAGGAGCTGGG

CGGCGAGTCCAACTTTGGTGACGCATTGCTGGATGCCGGCGAGTCCATGAAGCGCCTGGC

AGAGGTGAAGGACTCCCTGGACATCGAGGTCAAGCAGAACTTCATTGACCCCCTCCAGAA

CCTGTGCGAGAAAGACCTGAAGGAGATCCAGCACCACCTGAAGAAACTGGAGGGCCGCCG

CCTGGACTTTGACTACAAGAAGAAGCGGCAGGGCAAGATCCCCGATGAGGAGCTACGCCA

GGCGCTGGAGAAGTTCGAGGAGTCCAAGGAGGTGGCAGAAACCAGCATGCACAACCTCCT

GGAGACTGACATCGAGCAGGTGAGTCAGCTCTCGGCCCTGGTGGATGCACAGCTGGACTA

CCACCGGCAGGCCGTGCAGATCCTGGACGAGCTGGCGGAGAAGCTCAAGCGCAGGATGCG

GGAAGCTTCCTCACGCCCTAAGCGGGAGTATAAGCCGAAGCCCCGGGAGCCCTTTGACCT

TGGAGAGCCTGAGCAGTCCAACGGGGGCTTCCCCTGCACCACAGCCCCCAAGATCGCAGC

TTCATCGTCTTTCCGATCTTCCGACAAGCCCATCCGGACCCCTAGCCGGAGCATGCCGCC

CCTGGACCAGCCGAGCTGCAAGGCGCTGTACGACTTCGAGCCCGAGAACGACGGGGAGCT

GGGCTTCCATGAGGGCGACGTCATCACGCTGACCAACCAGATCGATGAGAACTGGTACGA

GGGCATGCTGGACGGCCAGTCGGGCTTCTTCCCGCTCAGCTACGTGGAGGTGCTTGTGCC

CCTGCCGCAGTGACTCACCCGTGTCCCCGCCCCGCCCCTCCGTCCACACTGGCCGGCACC

CCCTGCTGGGTCTCCTGCATTCCACGGAGCCCCTGCTGCCAGGGCGGTGTCTGAGCCTGC

CGGCGCCACCTGGGCCCCGGCCCTTGAGGTACTCCCTGAGCAGGACCCCACACTTGGGTG

GGGGGGCTTATCTGGGTGGGTGGGGATGCCTGTTTACACTAGCGCTGACTCCCAACGGTG

ACGGCTCCCTTCCCCACTCCATGGCGCCAGCCTCCTCCCCCGCTCCCCAACTTCTCGCCC

AGCTGGCCGAGGCGGGGCAACACTAAGGTGCTCTTAGAAACACTAATGTTCCTCTGGGGC

AGCCCCCACCTCCGTCCTGACCCGACGGGGGCCCGGCCCACTGCCTACCCTCGAGTCCCG

CAGCCTTAACAGGATGGGATCGAGGGTCCCCATGGGGTGGCTCAGAGATAGGACCCTGGT

TTTAAATCCCTCCCAGCCTGGTGCTGGTGATGGGCCCTGGCCCTACTCCAGGGCCAATGC

ACCCCCGCCTCACACACGCACTCCTTCTCCTCAAGGCCAGGGCAGAGGGCCTCACCGCCT

CCCGGGCCTGCTGTCAGCTTGCAGCCCGGGGACAGAGGCCAGCTGGGATCTGCCTGAGGA

CAGAGAACATGGTCTCCTGCAGGGCCCTGCCTCCCAAGCCCCGCCCTCAGAAAGCCAAGT

ACCTTTTCAGCTTTTTAACTGCCCCCATCCCAACCCAGGGAGGCCTGTGTCACTCTGGCA

CAAGCTGCCACCACCAGCCACCCACACCCACCCCAGCACACCTCACACGGGACCACAGCC

GCGCTGCCGAGGGCCAAGCACAAAGGTTCCAGTGAGCGCATGTCCCAGCCCCTGGTGGCC

AGGCTCCCCTTGCTGAGCCGCTGCCACTTCACCCTGTGGGAAGTGGCCCCAGCCATCTCC

TCTAGACCAAGGCAGGCAGCCCCGACATCTGCTTCCTCTATCGCCCAATGCAAAATCGAT

GAAATGGGGAGTTCTCTGGGCCAGGCCACATTCACATTCCCCTCCCCCTGTGGTCCAGTG

AAGCCTCCGGACCCCAGGCTCTGCTCTGCCCTGCCCTGCACCCCCCTCGTCAGAAGTACA

TGAGGGGCGCAGAGATGAGCACACAGCTTTGGGCACGGTCCAGGGCAAACTGAAATGTAC

GCCTGAATTTTGTAAACAGAAGTATTAAATGTCTCTTTCTACAAAAAAAAAAAAAAAAAA

>Hs.123078_mRNA_3 gi\|14328043\|gb\|BC009237.1\|BC009237 Homo sapiens clone
MGC:2216 IMAGE:2989823 polyA = 3
GGCACGAGGGAGGTGCAGAGCTGAGAATGAGGCGATTTCGGAGGATGGAGAAATAGCCCC

GAGTCCCGTGGAAAATGAGGCCGGCGGACTTGCTGCAGCTGGTGCTGCTGCTCGACCTGC

CCAGGGACCTGGGCGGAATGGGGTGTTCGTCTCCACCCTGCGAGTGCCATCAGGAGGAGG

ACTTCAGAGTCACCTGCAAGGATATTCAACGCATCCCCAGCTTACCGCCCAGTACGCAGA

CTCTGAAGCTTATTGAGACTCACCTGAGAACTATTCCAAGTCATGCATTTTCTAATCTGC

CCAATATTTCCAGAATCTACGTATCTATAGATGTGACTCTGCAGCAGCTGGAATCACACT

CCTTCTACAATTTGAGTAAAGTGACTCACATAGAAATTCGGAATACCAGGAACTTAACTT

ACATAGACCCTGATGCCCTCAAAGAGCTCCCCCTCCTAAAGTTCCTTGGCATTTTCAACA

CTGGACTTAAAATGTTCCCTGACCTGACCAAAGTTTATTCCACTGATATATTCTTTATAC

TTGAAATTACAGACAACCCTTACATGACGTCAATCCCTGTGAATGCTTTTCAGGGACTAT

GCAATGAAACCTTGACACTGAAGCTGTACAACAATGGCTTTACTTCAGTCCAAGGATATG

CTTTCAATGGGACAAAGCTGGATGCTGTTTACCTAAACAAGAATAAATACCTGACAGTTA

TTGACAAAGATGCATTTGGAGGAGTATACAGTGGACCAAGCTTGCTGCTGCCTCTTGGAA

GAAAGTCCTTGTCCTTTGAGACTCAGAAGGCCCCAAGCTCCAGTATGCCATCATGATGCC

TGCTAAGGCAGCCACCTTGGTGTACATGCTCACAGAGGCTCTGTTCATGGAGCAGCTGCT

GTTTGAAAAATTTTGAAATGCAAGATCCACAACTAGATGGAAGGCACTCTAGTCTTTGCA

GAAAAAAATGTACCTGAATGTACATTGCACAATGCCTGGCACAAAGAAGGAAGAATATAA

ATGATAGTTCGACTCGTCTGTGGAAGAACTTACAATCATGGGGAAAGATGGAATAAAAAC

ATTTTTTAAACAGCAAAAAAAAAAAAAAAAAA

>Hs.285508_contig1 AW194680\|BF939744\|BF516467 polyA = 1 polyA = 1
CCCCAGCCCCACTCACCCACCCTCCTTCCCACCAGCCTGCTCTCCGCAGGCCCACTGTCT

TTGGGTTTAATGACGTCTCTTCTCTGTGGAACTTCACGATTCCTTCCCACGGTCAACTCG

GGACCTCCCAGCGACCACTGCAGCCTGCGGACGAGGCCGGGACTTGGCCGAGCGGATCCT

AATAAGGGGAAAATGGTAAATGCAAACGTCCCGTTACAATTTTACCGCCAGTGTGCTGTC

GTTCCCCCTCCCCCTCTCCGAGTCCTCGTGGGGACACGGCGGGGTCTGTAGGAAGTTGGG

CCGGGTTGGGGGTTGCTAGAAGGCGCTGGTGTTTTGCTCTGAGTTTTAAGAGATCCCTTC

CTTCCTCTTCGGTGAATGCAGGTTATTTAAACTTTGGGAAATGTACTTTTAGTCTGTCAT

ATCAAGGCATGAGTCACTGTCTTTTTTTGTGTGAATAAATGGTTTCTAGTACAATGGA

>Hs.183274_contig1
BF437393\|BF064008\|BF509951\|AW134603\|AI277015\|AI803254\|AA887915\|BF054958\|AI0
04413\|AI393911\|AI278517\|AW612644\|AI492162\|AI309226\|AI863671\|AA448864\|AI6401
65\|AA479926\|AA461188\|AA780161\|BF591180\|AI918020\|AI758226\|AI291375\|BF001845\|
BF003064\|AI337393\|AI522206\|BE856784\|BF001760\|AI280300 FLAG = 1 polyA = 2 WARN
polyA = 3
GCGGCCGCCCGCACGTCCGCGGGTCCCGGCCGCGCCGCCGCCGCGCGCCCCTGCCCGAGA

GAGCTCTGGCCCCGCTAGCGGGGCCAGGAGCCGGGCCTCCCACCGCAGCGTCCCCCGCCG

CGCCAGTCCCCGCTAGTGGTAGTATCTCGTAATAGCTTCTGTGTGTGAGCTACCGTGGAT

CTCCTTCCCTTCTCTTGGGGGCCGGGGGGAAAGAAAAGGATTTAAGCAAAGGCTCCCTCG

CCCTGTGAGGGCGAGCGGCAAAGGCCCGGCTGAGCCCCCCATGCCCCTCCCCTCCCCGTG

TAAAAAGCCTCCTTGTGCAATTGTCTTTTTTTTCCTTTGAACGTGCTTCTTTGTAATGAC

CAAGGTACCGATTTCTGCTAAGTTCTCCCAACAACATGAAACTGCCTATTCACGCCGTAA

TTCTTTCTGTCTCCCTTCTCTCTCTCTCTCTCGCTCGCTCGCTCTCGCTCTCGCTCTCTC

TCGCTGCGTCCTCATTTCCCCTCCCAATCCTCTCTCCCCTCTGCAACCCCCCAGCTCGCT

GGCTTTCTCTCTGGCTTCTCTCTTTTCCTCCTCCACCCACCCCCTTTGGTTTGACAATTT

TGTCTTAAGTGTTTCTCAAAAGAGGTTACTTTAGTTAGCATGCGCGCTGTGGGCAATTGT

TACAAGTGTTCTTAGGTTTACTGTGAAGAGAATGTATTCTGTATCCGTGAATTGCTTTAT

GGGGGGGAGGGAGGGCTAATTATATATTTTGTTGTTCCTCTATACTTTGTTCTGTTGTCT

GCGCCTGAAAAGGGCGGAAGAGTTACAATAAAGTTTACAAGCGAGAACCCGAAAAAAAAA

AAAAA

>Hs.334841_mRNA_3 gi\|14290606\|gb\|BC009084.1\|BC009084 Homo sapiens clone
MGC:9270 IMAGE:3853674 polyA = 3
CACCAGCACAGCAAACCCGCCGGGATCAAAGTGTACCAGTCGGCAGCATGGCTACGAAAT

GTGGGAATTGTGGACCCGGCTACTCCACCCCTCTGGAGGCCATGAAAGGACCCAGGGAAG

AGATCGTCTACCTGCCCTGCATTTACCGAAACACAGGCACTGAGGCCCCAGATTATCTGG

CCACTGTGGATGTTGACCCCAAGTCTCCCCAGTATTGCCAGGTCATCCACCGGCTGCCCA

TGCCCAACCTGAAGGACGAGCTGCATCACTCAGGATGGAACACCTGCAGCAGCTGCTTCG

GTGATAGCACCAAGTCGCGCACCAAGCTGGTGCTGCCCAGTCTCATCTCCTCTCGCATCT

ATGTGGTGGACGTGGGCTCTGAGCCCCGGGCCCCAAAGCTGCACAAGGTCATTGAGCCCA

AGGACATCCATGCCAAGTGCGAACTGGCCTTTCTCCACACCAGCCACTGCCTGGCCAGCG

GGGAAGTGATGATCAGCTCCCTGGGAGACGTCAAGGGCAATGGCAAAGGGGGTTTTGTGC

TGCTGGATGGGGAGACGTTCGAGGTGAAGGGGACATGGGAGAGACCTGGGGGTGCTGCAC

CGTTGGGCTATGACTTCTGGTACCAGCCTCGACACAATGTCATGATCAGCACTGAGTGGG

CAGCTCCCAATGTCTTACGAGATGGCTTCAACCCCGCTGATGTGGAGGCTGGACTGTACG

GGAGCCACTTATATGTATGGGACTGGCAGCGCCATGAGATTGTGCAGACCCTGTCTCTAA

AAGATGGGCTTATTCCCTTGGAGATCCGCTTCCTGCACAACCCAGACGCTGCCCAAGGCT

TTGTGGGCTGCGCACTCAGCTCCACCATCCAGCGCTTCTACAAGAACGAGGGAGGTACAT

GGTCAGTGGAGAAGGTGATCCAGGTGCCCCCCAAGAAAGTGAAGGGCTGGCTGCTGCCCG

AAATGCCAGGCCTGATCACCGACATCCTGCTCTCCCTGGACGACCGCTTCCTCTACTTCA

GCAACTGGCTGCATGGGGACCTGAGGCAGTATGACATCTCTGACCCACAGAGACCCCGCC

TCACAGGACAGCTCTTCCTCGGAGGCAGCATTGTTAAGGGAGGCCCTGTGCAAGTGCTGG

AGGACGAGGAACTAAAGTCCCAGCCAGAGCCCCTAGTGGTCAAGGGAAAACGGGTGGCTG

GAGGCCCTCAGATGATCCAGCTCAGCCTGGATGGGAAGCGCCTCTACATCACCACGTCGC

TGTACAGTGCCTGGGACAAGCAGTTTTACCCTGATCTCATCAGGGAAGGCTCTGTGATGC

TGCAGGTTGATGTAGACACAGTAAAAGGAGGGCTGAAGTTGAACCCCAACTTCCTGGTGG

ACTTCGGGAAGGAGCCCCTTGGCCCAGCCCTTGCCCATGAGCTCCGCTACCCTGGGGGCG

ATTGTAGCTCTGACATCTGGATTTGAACTCCACCCTCATCACCCACACTCCCTATTTTGG

GCCCTCACTTCCTTGGGGACCTGGCTTCATTCTGCTCTCTCTTGGCACCCGACCCTTGGC

AGCATGTACCACACAGCCAAGCTGAGACTGTGGCAATGTGTTGAGTCATATACATTTACT

GACCACTGTTGCTTGTTGCTCACTGTGCTGCTTTTCCATGAGCTCTTGGAGGCACCAAGA

AATAAACTCGTAACCCTGTCCTTCAAAAAAAAAAAAAAAAA

>Hs.3321_contig1
AI804745\|AI492375\|AA594799\|BE672611\|AA814147\|AA722404\|AW170088\|D11718BG153
444\|AI680648\|AA063561\|BE219054\|AI590287\|R55185\|AI479167\|AI796872\|AI018324A
1701122\|BE218203\|AA905336\|AI681917B1084742\|AI480008\|AI217994\|AI401468
polyA = 2 polyA = 3
CCGGAGATAACTTGAGGGCTATAGAGGACCGGCTAATACTGGTCCTGAATTTGGCTTCAG

GCCTCACCAACCAAGTGGCCGTGGCCTTGCCGTCTTGCCCGTCGGCCCCCGGTGAGGCCT

GGACCCCTGGGGTCCCGGCACCAGGCCCCGGCTTCCGACCCTGGCAGAAGCCCAAGATCT

GGTCCCTCGCGGAGACTGCCACAAGCCCCGGACACCCGCGCCGGCTCGCCTCCCGGCGCG

GGGGGGTCTCCACCGGGGGGCAACGGTCGCGCCTTTCCGCCCTGCAGCTCTCTCCGGGCC

GCCGCCGCCGCCGCCGCTCACAGACTGGTCTCAGCGCCGCTGGGCAAGTTCCCGGCTTGG

ACCAACCGGCCGTTTCCAGGCCCACCGCCCGGCCCCCGCCCGCACCCGCTCTCCCTGCTG

GGCTCTGCCCCTCCGCACCTGCTGGGACTTCCCGGAGCCGCGGGCCACCCGGCTGCCGCC

GCCGCCTTCGCTCGGCCAGCGGAGCCCGAAGGCGGAACAGATCGCTGTAGTGCCTTGGAA

GTGGAGAAAAAGTTACTCAAGACAGCTTTCCATCCCGTGCCCAGGCGGCCCCAGAACCAT

CTGGACGCCGCCCTGGTCTTATCGGCTCTCTCCTCATCCTAGTTCTTTAAAAAAAAACAA

AAAAACAAAAAAAACTTTTTTTAATCGTTGTAATAATTGTATAAAAAAAATCGCTCTGTA

TAGTTACAACTTGTAAGCATGTCCGTGTATAAATACCTAAAAGCAAAACTAAACAAAGAA

AGTAAGAAAAAGAAATAAAACCAGTCCTCCTCAGCCCTCCCCAAGTCGCTTCTGTGGCAC

CCCGCATTCGCTGTGAGGTTTGTTTGTCCGGTTGATTTTGGGGGGTGGAGTTTCAGTGAG

AATAAACGTGTCTGCCTTTGTGTGTGTGTATATATACAGAGAAATGTACATATGTGTGAA

CCAAATTGTACGAGAAAGTATCTATTTTTGGCTAAATAAATGAGCTGCTGCCACTTTGAC

TATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.306216_singlet1 AW083022 polyA = 1 polyA = 2
TATGAGCACCTTCACATGGATCCACTTGAGGAAAGAAGGTGGACCGAATTTGTAAACGGT

GTGCAGCAATATATATCAATTCGTTCTGAGATAATCGCCACTTACGCTCTCTGTGGTTTT

GCCAATATCGGGTCCCTAGGAATCGTGATCGGCGGACTCACATCCATGGCTCCTTCCAGA

AAGCGTGATATCGCCTCGGGGGCAGTGAGAGCTCTGATTGCGGGGACCGTGGCCTGCTTC

ATGACAGCCTGCATCGCAGGCATACTCTCCAGCACTCCTGTGGACATCAACTGCCATCAC

GTTTTAGAGAATGCCTTCAACTCCACTTTCCCTGGAACCCCAACCAAGGGTGATAGCTTG

TTGCCAAAGTCTGTTGAGCAGCCCTGTTGCCCAGGGTCCTGGTGAAGTCATCCCAGGAGG

AAACCCCAGTCTGTATTCTTTGAAGGGCTGCTGCACATTGTTGAATCCATCGACCTTTAG

CTGCAATGGGATCTCTAATACATTTTGAGGTCAGCCACTTCTCCAGTGGAACTCTGAAGT

ACAGATGCTGAATTTTCTGCTTTGGAAAGAAAAAAAA

>Hs.99235_contig1 AA456140\|AI167259\|AA450056 polyA = 2 polyA = 3
ACTCGGCATGTGATGAACACCCATAGTTAAGAAACCATGGAGCAAGAAAGCTTGTGGAAA

GTCTCTCTCCTTCCTCATAAGACATGCACACTAATACACATACACACCAAAAAATTACAC

ATTTTAAAACTGCTAAGCTTGGATTTAACTGAATCATATATCTTTTATCATGTTATCCTA

AAAGTGAGAAGACATAACCAAGACATGGAAATAAATGTGAAAGCTGGAGCCGAAGAGTCA

ZVAGAGCTAAAAAATTAAGTCTAGAACATTCTATGAGGATAGTATAAATAAAAAGAAATAC

AGTCTAGACATGCTGCAAGGAAAGAAGATTCTAAAGTCCGTTTATGGAGGCAATTCCATA

TCCTTTCTTGAACGCACATTCAGCTTACCCCAGAGAGCAAGTGAGGCAATCTGGCAAAAG

ATTAATAAAGATGTAAACCCCTGGAAAAAAAAAAAA

>Hs.169172_mRNA_2 gi\|2274961\|emb\|AJ000388.1\|HSCANPX Homo sapiens mRNA for
calpain-like protease CANPX polyA = 3
GAATTCGGCACGAGATAGTTTTCAGGTTAAGAAAGCCAGAATCTTTGTTCAGCCACACTG

ACTGAACAGACTTTTAGTGGGGTTACCTGGCTAACAGCAGCAGCGGCAACGGCAGCAGCA

GCAGCAGCAGCAGCAGCAGCAGCAGCAGGGCTCCTGGGATAACTCAGGCATAGTTCAACA

CTATGGGTCCTCCTCTGAAGCTCTTCAAAAACCAGAAATACCAGGAACTGAAGCAGGAAT

GCATCAAAGACAGCAGACTTTTCTGTGATCCAACATTTCTGCCTGAGAATGATTCTCTTT

TCTACTTCCGACTGCTTCCTGGAAAGGTGGTGTGGAAACGTCCCCAGGACATCTGTGATG

ACCCCCATCTGATTGTGGGCAACATTAGCAACCACCAGCTGACCCAAGGGAGACTGGGGC

ACAAGCCAATGGTTTCTGCATTTTCCTGTTTGGCTGTTCAGGAGTCTCATTGGACAAAGA

CAATTCCCAACCATAAGGAACAGGAATGGGACCCTCAAAAAACAGAAAAATACGCTGGGA

TATTTCACTTTCGTTTCTGGCATTTTGGAGAATGGACTGAAGTGGTGATTGATGACTTGT

TGCCCACCATTAACGGAGATCTGGTCTTCTCTTTCTCCACTTCCATGAATGAGTTTTGGA

ATGCTCTGCTGGAAAAAGCTTATGCAAAGCTGCTAGGCTGTTATGAGGCCCTGGATGGTT

TGACCATCACTGATATTATTGTGGACTTCACGGGCACATTGGCTGAAACTGTTGACATGC

AGAAAGGAAGATACACTGAGCTTGTTGAGGAGAAGTACAAGCTATTCGGAGAACTGTACA

AAACATTTACCAAAGGTGGTCTGATCTGCTGTTCCATTGAGTCTCCCAATCAGGAGGAGC

AAGAAGTTGAAACTGATTGGGGTCTGCTGAAGGGCCATACCTATACCATGACTGATATTC

GCAAAATTCGTCTTGGAGAGAGACTTGTGGAAGTCTTCAGTGCTGAGAAGGTGTATATGG

TTCGCCTGAGAAACCCCTTGGGAAGACAGGAATGGAGTGGCCCCTGGAGTGAAATTTCTG

AAGAGTGGCAGCAACTGACTGCATCAGATCGCAAGAACCTGGGGCTTGTTATGTCTGATG

ATGGAGAGTTTTGGATGAGCTTGGAGGACTTTTGCCGCAACTTTCACAAACTGAATGTCT

GCCGCAATGTGAACAACCCTATTTTTGGCCGAAAGGAGCTGGAATCGGTGTTGGGATGCT

GGACTGTGGATGATGATCCCCTGATGAACCGCTCAGGAGGCTGCTATAACAACCGTGATA

CCTTCCTGCAGAATCCCCAGTACATCTTCACTGTGCCTGAGGATGGGCACAAGGTCATTA

TGTCACTGCAGCAGAAGGACCTGCGCACTTACCGCCGAATGGGAAGACCTGACAATTACA

TCATTGGCTTTGAGCTCTTCAAGGTGGAGATGAACCGCAAATTCCGCCTCCACCACCTCT

ACATCCAGGAGCGTGCTGGGACTTCCACCTATATTGACACCCGCACAGTGTTTCTGAGCA

AGTACCTGAAGAAGGGCAACTATGTGCTTGTCCCAACCATGTTCCAGCATGGTCGCACCA

GCGAGTTTCTCCTGAGAATCTTCTCTGAAGTGCCTGTCCAGCTCAGGGAACTGACTCTGG

ACATGCCCAAAATGTCCTGCTGGAACCTGGCTCGTGGCTACCCGAAAGTAGTTACTCAGA

TCACTGTTCACAGTGCTGAGGACCTGGAGAAGAAGTATGCCAATGAAACTGTAAACCCAT

ATTTGGTCATCAAATGTGGAAAGGAGGAAGTCCGTTCTCCTGTCCAGAAGAATACAGTTC

ATGCCATTTTTGACACCCAGGCCATTTTCTACAGAAGGACCACTGACATTCCTATTATAG

TACAGGTCTGGAACAGCCGAAAATTCTGTGATCAGTTCTTGGGGCAGGTTACTCTGGATG

CTGACCCCAGCGACTGCCGTGATCTGAAGTCTCTGTACCTGCGTAAGAAGGGTGGTCCAA

CTGCCAAAGTCAAGCAAGGCCACATCAGCTTCAAGGTTATTTCCAGCGATGATCTCACTG

AGCTCTAAATCTGCAATCCCAGAGAATCCTGACAAAGCGTGCCACCCTTTTATTTTCCGT

CAGGTGCCAGGTCTTAGTTAAGATTCACAATCTTTAGAAAGAATGAGATTCACAATAATT

AACTCTTCCTCTCTTCTGATAAATTCCCCATACCTCCCAATCCAAGTAGCATCTGTAGCT

ACATAACCTATATACCTCCAGCAGCTGGACATGGGGAGCGACAGTCCTATCTAGACATCA

TACACATTTGCCAAGAAAGGATCTCTGGGGCTTCCGGGGGTGAGATTCAAGCAGGACAAT

AACAAGAGGCTGGACACCCTACAGATGTCTTTGATGTTTTCAGTTGTTTGATATATCTCC

CCTGTAGGGCATGTTGAGGAAGGAGGAGGGCTGATCAAGGCCAAGCTGGTCTAGCCTGAC

ATCCTAGCTCCTGACTGAACACTATAGACTTCCCAGCAGCATTTTCACCCAGCAGCCAGA

GCCGGCTTTAAGTCCCCAACCCTTACAGACACCACTGCCACCACCACCAACCACGACCAC

CACCACCACCACCACTCACCACCATCATCACCTCCGGAAAGTGTAGTCCTGCCCTAACCC

TAACCCCAAGTCACCCCCCACAGTAAATTTTACCTTCATGTTGAGAAAGCTTCCTGGTGC

TTAATCAAGAGCTGGAGTTCAATGAGTCCTAGACAGTGAGAGGGGCCTGAGCTTCAGCTC

AATGGAAGCCTGCTGTGTGCTCACAAGACGGAAAAGTGGAAGAAGCTGCAGTGGGAGACA

AAGCCTCGGTCCCCCACCCATCCACACACACCTACACTCACACACGCGCACATGGGCGCG

CAACGGAACTACCATTTCAGGCAGTCAGTGGGCAAGAGGAAAGATAAGTAAGTACCATAC

ACACCTTAAAAGATGAGGAGAATTCATCCAGACATATTACAGCCAGTTTGGGGCCCCTGA

CTTGCAATGTGAAACCTCTTCGCTTGCTGCTAGGTTTACAAACAAGCCCATTGTTCCTGT

GCCTCCTAATATTCATTTGTTACTGAAGGACCCCATCTGGGGACTTGAGACTTTGGTCCC

AGCCCAGACGCCTCAGACTGGTCTCAAAGTCAAGCAAGGCTTCACATCAGCTGCAAGTGT

TAGTTTGCCAGCGCATGATCTCACTGAGCTTCTACAGAATCTGCAATCCCAGAGTCAATC

ATGACGAAATGTACGTCCCACCATCTTAACCTATCAACTTTCTGCCCCTCCTTCAAGGCC

CAGTATAAATGCCACCTCCTCCATGAAGCCTTCCCTAATTCCACCCCAAACCCCCACCTT

CAACAATATTTCAACGCTTCTGCAATGATGAAAAAGAAACATAGTTGTAGTACTTAGCCT

ACCTAGACCAGCAAGCATTCATTTTTAGCTCGCTCATTTTTTACCATGTTTTCCAGTCTG

TTTAACTTCTGCAGTGCCTTCACTACACTGCCTTACATAAACCAAATCACAATAAAGTTC

ATATTCAGTACAATTAAAAAAAAAAAAA

>Hs.351486_mRNA_1 gi\|16549178\|dbj\|AK054605.1\|AK054605 Homo sapiens cDNA
FLJ30043 fis, clone 3NB692001548 polyA = 0
TATGCAAGTGTTTAACAGATGCTTCACTATTAAAATATTTTCCCCCCAAGTCTCAAATAT

TGAAGAATCTCTAACCAGGGACACCAGTCCCTACGAAGACCTTGGGCGATTTTGAAGTGC

GGGCACCTCGATTCCCCGAATCTGTAGTGTGGCTGGTATCGGTGTTCCCCTGGTTTAACT

AGCCTGTTTGAAGGCACAGATCATTCATGGGGAAGTATAACCGAATCCAGTCCTCTCCAC

CGCCTGGGGATCTTCACTTTCGCAGTCTACGACTGCCTGTGACTCCAGAAAGACAAACTG

CAGATTGGCCAAGATGGGGAAATTGAGGCAGAGAAGCCAAGACATGTGCTAAAGGTCATG

CAGGCTATGAATGGAGCTGGAATGTGAACGCAGGCCATATGACCCCAGAGCCCATGTTCT

TGAACCCTTAGAAAGACAGCAGCAACACACCTGGTGCAGCAGCTGCTTAGTTGGAGTGGC

TGACAAGGAGAGAATGATTTCCAGGAAGAGCGGAACACATATGGAAGGCCTTAGCTTATC

TTTAGCGCCTCATACACCCGTTCTGGACTTCAGAAAGGCCAGTGAGTGGGATTAGGCCTC

AGAGATAGGATGTCAGTCCCAGTGAGGGATGGCCTAGAGCATTCTTTAATTCTTTCCTTT

GGGTCACACATAAGAAACAATTTTCCAGCACTGATGAGTGTTATTAACAATGAGATGGGA

TAGAATTTAGTTTTCCCTATGGCTGTGCTTCAAAAATAGAAAAGCTGTCTTTTCTCTGGA

ATGATTGAATGAAGCTCTGGGGAGGAAAAGGTGGATTGGCAGATCTCTTAAAGGAAGCTT

CTCCTTCTAGGCACTATTCTAAGGCTTAATATTTTAACTCCCTATATTAACCTAGTTCAA

CTAAACAGTGATCTGAGTAATTTTATTTTTATTAAAGCTCAGATCAAAATGCCATTAACA

TTGATTGAGAAAATCAAAGGAATCTTTGATGTGAGTGGTTAAATTGCTGAATTATTTCAG

TCCCATACCCTCACAGCATGAGTACCTGATCTGATAGACTTCTTTGGAATTCCTTTTTTG

TTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGCGGTGTGATCTCAACCAT

TGCAACCTCCACCTCCCAGGTTCAGGTGATTCTCATGCCTCAGCCTCCTGAGTAGCTGGG

ATTACAGATGTGCACCACCATGCCCGGCTAATTATTTTGTATCTTTAGTAGAGATGAAGT

TTTGCCATGTGGGCCAGGCTGTTCTCAAACTACTGGCCTCAAGTGATCTGCCCGCCTCGG

CCTCCCAGACTGCTGGGATTACAGGCGTGAGGCACCGTGCCTGGCTGGGATTCCATAATA

AATCCCTCTGTGTCTATTTCTTTTTTCAAATATAATTTTCTTCATTTCCAAACATCATCT

TTAAGACTCCAAGGATTTTTCCAGGCACAGTGGCTCATACCTGTAATCCCATTGCTTGGA

GAGGCCAAGGTGGAAGTTCATTTGAGGCCAGGAGTTCGAGACCAGGTGGGCAACATAGTG

AAACCTTGTCTCTACAACAT

>Hs.153504_contig2
BE962007\|AW016349\|AW016358\|AW139144\|AA932969\|AI025620\|AI688744\|AI865632\|AA8
54291\|AA932970\|AU156702\|AI634439\|AA152496\|AI539557\|AI123490\|AI613215\|AI3183
63\|AW105672\|AA843483\|AI366889\|AW1819381AI813801\|AI433695\|AA934772\|N72230\|AT
760632\|BE858965\|AW058302\|AI760087\|AI682077\|AA886672\|AI350384\|AW243848\|AW300
574\|BE466359\|AI859529\|AI921588\|BF062899\|BE855597 BE617708 polyA = 2 polyA = 3
TGTTTATATAACTGTGTTCGTTTTTGTTGTTCCGTCCCGTCGTCCTTGTAGACTCTCATC

CTCGTGTGTTTTGGACCCTCCAGGGGTGACATCGGGTCTTGTGTTCAGCTCTCCTGGACT

GTTATTCCTTGTCCGCGTGTTCGTGTTAGACATTGTCCACGATCTGTATCATGCCTATGT

CTCACTTTGGTCTCTTATTTCAGCGTGAACACTATAGTTCCAAGTTTGTTCGGATAATTC

TGATTCTTGTCACCAGCGTGAGATTTCAACAGAACTTGTTTGGAACAAATACTCACTTAA

AACTTCAGCAGAAGAAAAATTACTTAGTCCTTAGGCCAACCAATTTAACTGCAGTGTCAT

GTTTCACAGGCCTTCCTACATTTAGAAATCGTCACACAGCTGTGATAAGAGTAGATTATT

TTACTATGAAATAATTCTGAATAGATGAAAGCATAAAATGTGAGAAACTGAATGTATTAT

TCAGGAAGAATACTGAGTGCCTTCATTTAACTAAAGTTGAATGTAAAAGTCAATTTGCAC

TTCTTTATAATCCTCTGGTTTAGAATTATAAATTGTTAAAACCTTGATAATTGTCATTTA

ATTATATTTCAGGTGTCCTGAACAGGTCACTAGACTCTACATTGGGCAGCCTTTAAATAT

GATTCTTTGTAATGCTAAATAGCCTTTTTTTCTCTTTTTACTGCAACTTAATATTTCTAT

TTAGAACACAGAAAATGAAAATATTTAGAATAAGTTGTACATTTGATGACAAATAAATCA

CTATTAAAATAAAAAAAAAAAAAAAAAAA

>Hs.199354_singletl AI669760 polyA = 1 polyA = 2
AGGAACCCCTGTGGGAAAGGTTTAAACCTATkAACAGTGCCCCCTTTGGCTCCTCCTCCCT

TGGCGGAATGGGTTCCTGGACCATGTGCATTTCANTGGGCCATGGGATTTACATTTCCTT

GCATCCCCAGGTGGTTTGATCCCTGCCAGGGCCCCTTCCTTCCTGCTCATGGTTTTCAGG

GGGCCTGATCATGGAAAGTAAGGGGGTTGGGCCTTCCCTTTTGGGGGTGAACCCTGACTC

CATCCCCCTATTGCCCCCCTAACCAATCATGCAAACTTTTCCCCCCCTGGGGTAATTCAC

CAGTTAAAAAAAGCTTTTTTTAAATGTTTTGTTTTGGGGGGGGGGCAGGGCCCCCTTTTT

GTTTTTTTAAGGAGTTGGTTTTGGTTTTTGGCTGATGTTTTGTTTTTTAACATGCCCCCA

GTTTGTAAGGCCAAAGGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAA

>Hs.162020_contig1 AW291189\|AA505872 polyA = 2 polyA = 3
TAAGCTTTAAAGGCTCTGTGTTAGGGCATAGTCTAGAAACATGGGGCCCAAGGGCACCGG

GAAAACTTACAAAGGGAAGAGATGGAACTGGGAGGGTTCAAGCTACCAGTTCCATCTCTC

CATGTTTTAGAGAATTGGGGCACTAAGTCAGCCAGGTAAGGTCAGGTCAGAGGAGGGCCC

GGATGAAGCATGAGATGCAGAGGGACAGTGCGTGAATGGAGACCTTGGGTAGCACCAACG

TGTAGCGGCAGAGGTGGGGTGGATGTGGCTGATGTCAGGGAGAGAATGGGGAGCATGCAC

AGGGCTCAGTCTTATACATACATTGAAAATCCTTTAGCCTTTCAAAGATTATTAACCCAA

ATCACCTTTCTTGCTTACTCCAGATGCCTCAGCCTCTGATATAATTGCTAAGTATCTGCC

GTGTTAAAAATAAACATTTGAGAATCAAAAAAAAAAAAAAAAA

>Hs.30743_mRNA_3 gi\|18201906\|ref\|NM_006115.2\|Homo sapiens preferentially
expressed antigen in melanoma (FRAME), mRNA polyA = 3
GCTTCAGGGTACAGCTCCCCCGCAGCCAGAAGCCGGGCCTGCAGCGCCTCAGCACCGCTC

CGGGACACCCCACCCGCTTCCCAGGCGTGACCTGTCAACAGCAACTTCGCGGTGTGGTGA

ACTCTCTGAGGAAAAACCATTTTGATTATTACTCTCAGACGTGCGTGGCAACAAGTGACT

GAGACCTAGAAATCCAAGCGTTGGAGGTCCTGAGGCCAGCCTAAGTCGCTTCAAAATGGA

ACGAAGGCGTTTGTGGGGTTCCATTCAGAGCCGATACATCAGCATGAGTGTGTGGACAAG

CCCACGGAGACTTGTGGAGCTGGCAGGGCAGAGCCTGCTGAAGGATGAGGCCCTGGCCAT

TGCCGCCCTGGAGTTGCTGCCCAGGGAGCTCTTCCCGCCACTCTTCATGGCAGCCTTTGA

CGGGAGACACAGCCAGACCCTGAAGGCAATGGTGCAGGCCTGGCCCTTCACCTGCCTCCC

TCTGGGAGTGCTGATGAAGGGACAACATCTTCACCTGGAGACCTTCAAAGCTGTGCTTGA

TGGACTTGATGTGCTCCTTGCCCAGGAGGTTCGCCCCAGGAGGTGGAAACTTCAAGTGCT

GGATTTACGGAAGAACTCTCATCAGGACTTCTGGACTGTATGGTCTGGAAACAGGGCCAG

TCTGTACTCATTTCCAGAGCCAGAAGCAGCTCAGCCCATGACAAAGAAGCGAAAAGTAGA

TGGTTTGAGCACAGAGGCAGAGCAGCCCTTCATTCCAGTAGAGGTGCTCGTAGACCTGTT

CCTCAAGGAAGGTGCCTGTGATGAATTGTTCTCCTACCTCATTGAGAAAGTGAAGCGAAA

GAAAAATGTACTACGCCTGTGCTGTAAGAAGCTGAAGATTTTTGCAATGCCCATGCAGGA

TATCAAGATGATCCTGAAAATGGTGCAGCTGGACTCTATTGAAGATTTGGAAGTGACTTG

TACCTGGAAGCTACCCACCTTGGCGAAATTTTCTCCTTACCTGGGCCAGATGATTAATCT

GCGTAGACTCCTCCTCTCCCACATCCATGCATCTTCCTACATTTCCCCGGAGAAGGAAGA

GCAGTATATCGCCCAGTTCACCTCTCAGTTCCTCAGTCTGCAGTGCCTGCAGGCTCTCTA

TGTGGACTCTTTATTTTTCCTTAGAGGCCGCCTGGATCAGTTGCTCAGGCACGTGATGAA

CCCCTTGGAAACCCTCTCAATAACTAACTGCCGGCTTTCGGAAGGGGATGTGATGCATCT

GTCCCAGAGTCCCAGCGTCAGTCAGCTAAGTGTCCTGAGTCTAAGTGGGGTCATGCTGAC

CGATGTAAGTCCCGAGCCCCTCCAAGCTCTGCTGGAGAGAGCCTCTGCCACCCTCCAGGA

CCTGGTCTTTGATGAGTGTGGGATCACGGATGATCAGCTCCTTGCCCTCCTGCCTTCCCT

GAGCCACTGCTCCCAGCTTACAACCTTAAGCTTCTACGGGAATTCCATCTCCATATCTGC

CTTGCAGAGTCTCCTGCAGCACCTCATCGGGCTGAGCAATCTGACCCACGTGCTGTATCC

TGTCCCCCTGGAGAGTTATGAGGACATCCATGGTACCCTCCACCTGGAGAGGCTTGCCTA

TCTGCATGCCAGGCTCAGGGAGTTGCTGTGTGAGTTGGGGCGGCCCAGCATGGTCTGGCT

TAGTGCCAACCCCTGTCCTCACTGTGGGGACAGAACCTTCTATGACCCGGAGCCCATCCT

GTGCCCCTGTTTCATGCCTAACTAGCTGGGTGCACATATCAAATGCTTCATTCTGCATAC

TTGGACACTAAAGCCAGGATGTGCATGCATCTTGAAGCAACAAAGCAGCCACAGTTTCAG

ACAAATGTTCAGTGTGAGTGAGGAAAACATGTTCAGTGAGGAAAAAACATTCAGACAAAT

GTTCAGTGAGGAAAAAAAGGGGAAGTTGGGGATAGGCAGATGTTGACTTGAGGAGTTAAT

GTGATCTTTGGGGAGATACATCTTATAGAGTTAGAAATAGAATCTGAATTTCTAAAGGGA

GATTCTGGCTTGGGAAGTACATGTAGGAGTTAATCCCTGTGTAGACTGTTGTAAAGAAAC

TGTTGAAAATAAAGAGAAGCAATGTGAAGCAAAAAAAAAAAAAAAAAA

>Hs.271580_contig1
AI632869\|AW338882\|AW338875\|AW613773\|AI982899\|AW193151\|BE206353\|BE208200\|AI8
11548\|AW264021 polyA = 2 polyA = 3
AACACAGCCCTACCAANCAATGATGACCAGTGGAAAACAATGAAGTCACCAAACCCTGGA

CAGGGCTCATGCTCCAGGACAANTTGCTGTGGCGTAAATGGTCCATCAGACTGGCAAAAA

TACACATCTGCCTTCCGGACTGAGAATAATGATGCTGACTATCCCTGGCCTCGTCAATGC

TGTGTTATGAACAATCTTAAAGAACCTCTCAACCTGGAGGCTTGTAAACTAGGCGTGCCT

GGTTTTTATCACAATCAGGGCTGCTATGAACTGATCTCTGGTCCAATGAACCGACACGCC

TGGGGGGTTGCCTGGTTTGGATTTGCCATTCTCTGCTGGACTTTTTGGGTTCTCCTGGGT

ACCATGTTCTACTGGAGCAGAATTGAATATTAAGCATAAAGTGTTGCCACCATACCTCCT

TCCCCGAGTGACTCTGGATTTGGTGCTGGAACCAGCTCTCTCCTAATATTCCACGTTTGT

GCCCCACACTAACGTGTGTGTCTTACATTGCCAAGTCAGATGGTACGGACTTCCTTTAGG

ATCTCAGGCTTCTGCAGTTCTCATGACTCCTACTTTTCATCCTAGTCTAGCATTCTGCAA

CATTTATATAGACTGTTGAAAGGAGAATTTGAAAAATGCATAATAACTACTTCCATCCCT

GCTTATTTTTAATTTGGGAAAATAAATACATTCGAAGGAAAAAAAAA

>Hs.69360_mRNA_2 gi\|14250609\|gb\|BC008764.11BC008764 Homo sapiens clone
MGC:1266 IMAGE:3347571 polyA = 3
GGCACGAGGGCGAAATTGAGGTTTCTTGGTATTGCGCGTTTCTCTTCCTTGCTGACTCTC

CGAATGGCCATGGACTCGTCGCTTCAGGCCCGCCTGTTTCCCGGTCTCGCTATCAAGATC

CAACGCAGTAATGGTTTAATTCACAGTGCCAATGTAAGGACTGTGAACTTGGAGAAATCC

TGTGTTTCAGTGGAATGGGCAGAAGGAGGTGCCACAAAGGGCAAAGAGATTGATTTTGAT

GATGTGGCTGCAATAAACCCAGAACTCTTACAGCTTCTTCCCTTACATCCGAAGGACAAT

CTGCCCTTGCAGGAAAATGTAACAATCCAGAAACAAAAACGGAGATCCGTCAACTCCAAA

ATTCCTGCTCCAAAAGAAAGTCTTCGAAGCCGCTCCACTCGCATGTCCACTGTCTCAGAG

CTTCGCATCACGGCTCAGGAGAATGACATGGAGGTGGAGCTGCCTGCAGCTGCAAACTCC

CGCAAGCAGTTTTCAGTTCCTCCTGCCCCCACTAGGCCTTCCTGCCCTGCAGTGGCTGAA

ATACCATTGAGGATGGTCAGCGAGGAGATGGAAGAGCAAGTCCATTCCATCCGAGGCAGC

TCTTCTGCAAACCCTGTGAACTCAGTTCGGAGGAAATCATGTCTTGTGAAGGAAGTGGAA

AAAATGAAGAACAAGCGAGAAGAGAAGAAGGCCCAGAACTCTGAAATGAGAATGAAGAGA

GCTCAGGAGTATGACAGTAGTTTTCCAAACTGGGAATTTGCCCGAATGATTAAAGAATTT

CGGGCTACTTTGGAATGTCATCCACTTACTATGACTGATCCTATCGAAGAGCACAGAATA

TGTGTCTGTGTTAGGAAACGCCCACTGAATAAGCAAGAATTGGCCAAGAAAGAAATTGAT

GTGATTTCCATTCCTAGCAAGTGTCTCCTCTTGGTACATGAACCCAAGTTGAAAGTGGAC

TTAACAAAGTATCTGGAGAACCAAGCATTCTGCTTTGACTTTGCATTTGATGAAACAGCT

TCGAATGAAGTTGTCTACAGGTTCACAGCAAGGCCACTGGTACAGACAATCTTTGAAGGT

GGAAAAGCAACTTGTTTTGCATATGGCCAGACAGGAAGTGGCAAGACACATACTATGGGC

GGAGACCTCTCTGGGAAAGCCCAGAATGCATCCAAAGGGATCTATGCCATGGCCTCCCGG

GACGTCTTCCTCCTGAAGAATCAACCCTGCTACCGGAAGTTGGGCCTGGAAGTCTATGTG

ACATTCTTCGAGATCTACAATGGGAAGCTGTTTGACCTGCTCAACAAGAAGGCCAAGCTG

CGCGTGCTGGAGGACGGCAAGCAACAGGTGCAAGTGGTGGGGCTGCAGGAGCATCTGGTT

AACTCTGCTGATGATGTCATCAAGATGATCGACATGGGCAGCGCCTGCAGAACCTCTGGG

CAGACATTTGCCAACTCCAATTCCTCCCGCTCCCACGCGTGCTTCCAAATTATTCTTCGA

GCTAAAGGGAGAATGCATGGCAAGTTCTCTTTGGTAGATCTGGCAGGGAATGAGCGAGGC

GCGGACACTTCCAGTGCTGACCGGCAGACCCGCATGGAGGGCGCAGAAATCAACAAGAGT

CTCTTAGCCCTGAAGGAGTGCATCAGGGCCCTGGGACAGAACAAGGCTCACACCCCGTTC

CGTGAGAGCAAGCTGACACAGGTGCTGAGGGACTCCTTCATTGGGGAGAACTCTAGGACT

TGCATGATTGCCACGATCTCACCAGGCATAAGCTCCTGTGAATATACTTTAAACACCCTG

AGATATGCAGACAGGGTCAAGGAGCTGAGCCCCCACAGTGGGCCCAGTGGAGAGCAGTTG

ATTCAAATGGAAACAGAAGAGATGGAAGCCTGCTCTAACGGGGCGCTGATTCCAGGCAAT

TTATCCAAGGAAGAGGAGGAACTGTCTTCCCAGATGTCCAGCTTTAACGAAGCCATGACT

CAGATCAGGGAGCTGGAGGAGAAGGCTATGGAAGAGCTCAAGGAGATCATACAGCAAGGA

CCAGACTGGCTTGAGCTCTCTGAGATGACCGAGCAGCCAGACTATGACCTGGAGACCTTT

GTGAACAAAGCGGAATCTGCTCTGGCCCAGCAAGCCAAGCATTTCTCAGCCCTGCCAGAT

GTCATCAAGGCCTTGCGCCTGGCCATGCAGCTGGAAGAGCAGGCTAGCAGACAAATAAGC

AGCAAGAAACGGCCCCAGTGACGACTGCAAATAAAAATCTGTTTGGTTTGACACCCAGCC

TCTTCCCTGGCCCTCCCCAGAGAACTTTGGGTACCTGGTGGGTCTAGGCAGGGTCTGAGC

TGGGACAGGTTCTGGTAAATGCCAAGTATGGGGGCATCTGGGCCCAGGGCAGCTGGGGAG

GGGGTCAGAGTGACATGGGACACTCCTTTTCTGTTCCTCAGTTGTCGCCCTCACGAGAGG

AAGGAGCTCTTAGTTACCCTTTTGTGTTGCCCTTCTTTCCATCAAGGGGAATGTTCTCAG

CATAGAGCTTTCTCCGCAGCATCCTGCCTGCGTGGACTGGCTGCTAATGGAGAGCTCCCT

GGGGTTGTCCTGGCTCTGGGGAGAGAGACGGAGCCTTTAGTACAGCTATCTGCTGGCTCT

AAACCTTCTACGCCTTTGGGCCGAGCACTGAATGTCTTGTACTTTAAAAAAATGTTTCTG

AGACCTCTTTCTACTTTACTGTCTCCCTAGAGATCCTAGAGGATCCCTACTGTTTTCTGT

TTTATGTGTTTATACATTGTATGTAACAATAAAGAGAAAAAATAAAAAAAAAAAAAAAAA

AAAAAAAAAAAA

>Hs.30827_contig1 H07885\|N39347\|W85913\|AA583408\|W86449 polyA = 2 polyA = 3
ATCGGACTTCGGTNAACTNTGGCAAGGATTGGACAGNCTAGGTAGGCTAAATGTGTGCTC

TGTCCCTGTTTGCTTCAACAGAGGAGCAAGCCTCAGCTGAGAAGGAGGGCACNTGGAACA

CCTAGCTCCTCCCGTGATTCCCCAAACCCATAACATTCTTCCATAGGGCTGGAACCAGTG

CCCCGTCCTGACAGGGATGAAAAGTGAACCCCTCAGGTCAGGAGAGGCCAGAGTTGAGGT

TCTGCCACTTCCTGTCCCTGGGGAGCCACTCAAGTTACCAGGGCTACCGGCTGAAATAAA

TCTTTTCCGGGTAGGGTCAAGGGCAGTGTGTTCCAAGGCAACTGATGTAGGCCAGTTGCG

TGACTCCAGGTTTGTCCTGGTACTCAGTGGGTCCAATCACCTGGCATTGATCACCTGGCA

TTGATCAGCACCCACCCCACCCCTGAGGCTTGCCCAGCCCCCAGGCCCTCAGATCCCTGC

TCTTCCTGCCTTTCCTGCCCATGTGTCACCCAGCACCCAAGGTTCAGTGACACAGGGTGG

TTTGGAGCTGGTCACTGTCATAGCAGCTGTGATTTCACAAGGAAGGGTGCTGCAGGGGGA

CCTGGTTGATGGGGAGTGGGAAGGGGAAGGAATAAAGAGATCTTCCTCAGGTAAAAAAAA

AAAAAAAAAA

>Hs.211593_contig2
BF592799\|AI570478\|AA234440\|R40214\|BE501078\|AW593784\|AI184050\|
AI284161\|W72149\|AW780437\|AI247981\|AW241273\|H60824 polyA = 2 polyA = 3
ACCTCGTTTGCTCCCAGTTACTTCTTATCTGGAGCAGTAATGTAGTCCACTTCACTCATG

CCTACCCCGCGTGTCTCGTCTCCTGACATGTCTCACAGACGCTCCTGAAGTTAGGTCATT

ACCTAACCCATAGTTATTTACCTTGAAAGATGGGTCTCCGCACTTGGAAAGGTTTCAAGA

CTTGATACTGCAATAAATTATGGCTCTTCACCTGGGCGCCAACTGCTGATCAACGAAATG

CTTGTTGAATCAGGGGCAAACGGAGTACAGACGTCTCAAGACTGAAACGGCCCCATTGCC

TGGTCTAGTAGCGGATCTCACTCAGCCGCAGACAAGTAATCACTAACCCGTTTTATTCTA

TTCCTATCTGTGGATGTGTAAATGGCTGGGGGGCCAGCCCTGGATAGGTTTTTATGGGAA

TTCTTTACAATAAACATAGCTTGTAACTTGAGATCTACAAATCCATTCATCCTGATTGGG

CATGAAATCCATGGTCAAGAGGACAAGTGGAAAGTGAGAGGGAAGGTTTGCTAGACACCT

TCGCTTGTTATCTTGTCAAGATAGAAAAGATAGTATCATTTCACCCTTGCCAGTAAAAAC

CTTTCCATCCACCCATTCTCAGCAGACTCCAGTATTGGCACAGTCACTCACTGCCATTCT

CACACTATAACAAGAAAAGAAATGAAGTGCATAAGTCTCCTGGGAAAAGAACCTTAACCC

CTTCTCGTGCCATGACTGGTGATTTCATGACTCATAAGCCCCTCCGTAGGCATCATTCAA

GATCAATGGCCCATGCATGCTGTTTGCAGCAGTCAATTGAGTTGAATTAGAATTCCAACC

ATACATTTTAAAGGTATTTGTGCTGTGTGTATATTTTGATAAAATGTTGTGACTTCATGG

CAAACAGGTGGATGTGTAAAAATGGAATAAAAAAAAAAAAAGAGTCAAAAAAAAAAAAAA

AATT

>Hs.155097_mRNA_1 gi\|15080385\|gb\|BC011949.1\|BC011949 Homo sapiens clone
MGC:9006 IMAGE:3863603 polyA = 3
GGCGCCCAAGCCGCCGCCGCCAGATCGGTGCCGATTCCTGCCCTGCCCCGACCGCCAGCG

CGACCATGTCCCATCACTGGGGGTACGGCAAACACAACGGACCTGAGCACTGGCATAAGG

ACTTCCCCATTGCCAAGGGAGAGCGCCAGTCCCCTGTTGACATCGACACTCATACAGCCA

AGTATGACCCTTCCCTGAAGCCCCTGTCTGTTTCCTATGATCAAGCAACTTCCCTGAGGA

TCCTCAACAATGGTCATGCTTTCAACGTGGAGTTTGATGACTCTCAGGACAAAGCAGTGC

TCAAGGGAGGACCCCTGGATGGCACTTACAGATTGATTCAGTTTCACTTTCACTGGGGTT

CACTTGATGGACAAGGTTCAGAGCATACTGTGGATAAAAAGAAATATGCTGCAGAACTTC

ACTTGGTTCACTGGAACACCAAATATGGGGATTTTGGGAAAGCTGTGCAGCAACCTGATG

GACTGGCCGTTCTAGGTATTTTTTTGAAGGTTGGCAGCGCTAAACCGGGCCTTCAGAAAG

TTGTTGATGTGCTGGATTCCATTAAAACAAAGGGCAAGAGTGCTGACTTCACAAACTTTG

CAGCTCGTGGCCTCCTTCCTGAATCCCTGGATTACTGGACCTACCCAGGCTCACTGACCA

CCCCTCCTCTTCTGGAATGTGTGACCTGGATTGTGCTCAAGGAACCCATCAGCGTCAGCA

GCGAGCAGGTGTTGAAATTCCGTAAACTTAACTTCAATGGGGAGGGTGAACCCGAAGAAC

TGATGGTGGACAACTGGCGCCCAGCTCAGCCACTGAAGAACAGGCAAATCAAAGCTTCCT

TCAAATAAGATGGTCCCATAGTCTGTATCCAAATAATGAATCTTCGGGTGTTTCCCTTTA

GCTAAGCACAGATCTACCTTGGTGATTTGGACCCTGGTTGCTTTGTGTCTAGTTTTCTAG

ACCCTTCATCTCTTACTTGATAGACTTACTAATAAAATGTGAAGACTAGACCAATTGTCA

TGCTTGACACAACTGCTGTGGCTGGTTGGTGCTTTGTTTATGGTAGTAGTTTTTCTGTAA

CACAGAATATAGGATAAGAAATAAGAATAAAGTACCTTGACTTTGTTCACAGCATGTAGG

GTGATGAGCACTCACAATTGTTGACTAAAATGCTGCCTTTAAAACATAGGAAAGTAGAAT

GGTTGAGTGCAAATCCATAGCACAAGATAAATTGAGCTAGTTAAGGCAAATCAGGTAAAA

TAGTCATGATTCTATGTAATGTAAACCAGAAAAAATAAATGTTCATGATTTCAAGATGTT

ATATTAAAGAAAAACTTTAAAAATTATTATATATTTATAGCAAAGTTATCTTAAATATGA

ATTCTGTTGTAATTTAATGACTTTTGAATTACAGAGATATAAATGAAGTATTATCTGTAA

AAATTGTTATAATTAGAGTTGTGATACAGAGTATATTTCCATTCAGACAATATATCATAA

CTTAATAAATATTGTATTTTAGATATATTCTCTAATAAAATTCAGAATTCTAAAAAAAAA

AAAAAAAA

>Hs.5163_mRNA_1 gi\|15990433\|gb\|BC015582.1\|BC015582 Homo sapiens clone
MGC:23280 IMAGE:4637504 polyA = 3
GGCACGAGGCATGGAGGCGCTGCTGCTGGGCGCGGGGTTGCTGCTGGGCGCTTACGTGCT

TGTCTACTACAACCTGGTGAAGGCCCCGCCGTGCGGCGGCATGGGCAACCTGCGGGGCCG

CACGGCCGTGGTCACGGGTGAGTGCGGAGGCGGGTGAGTGCGAGCTGGCGGGGCGCGCGG

AGAGGAGGCCGGGCCGGCGGTAGCAGCGGCCCGCCGGGCTCAGCTCAGCTCGGCTCCCGC

CCGCGGTCCGCAGGCGCCAACAGCGGCATCGGAAAGATGACGGCGCTGGAGCTGGCGCGC

CGGGGAGCGCGCGTGGTGCTGGCCTGCCGCAGCCAGGAGCGCGGGGAGGCGGCTGCCTTC

GACCTCCGCCAGGAGAGTGGGAACAATGAGGTCATCTTCATGGCCTTGGACTTGGCCAGT

CTGGCCTCGGTGCGGGCCTTTGCCACTGCCTTTCTGAGCTCTGAGCCACGGTTGGACATC

CTCATCCACAATGCCGGTATCAGTTCCTGTGGCCGGACCCGTGAGGCGTTTAACCTGCTG

CTTCGGGTGAACCATATCGGTCCCTTTCTGCTGACACATCTGCTGCTGCCTTGCCTGAAG

GCATGTGCCCCTAGCCGCGTGGTGGTGGTAGCCTCAGCTGCCCACTGTCGGGGACGTCTT

GACTTCAAACGCCTGGACCGCCCAGTGGTGGGCTGGCGGCAGGAGCTGCGGGCATATGCT

GACACTAAGCTGGCTAATGTACTGTTTGCCCGGGAGCTCGCCAACCAGCTTGAGGCCACT

GGCGTCACCTGCTATGCAGCCCACCCAGGGCCTGTGAACTCGGAGCTGTTCCTGCGCCAT

GTTCCTGGATGGCTGCGCCCACTTTTGCGCCCATTGGCTTGGCTGGTGCTCCGGGCACCA

AGAGGGGGTGCCCAGACACCCCTGTATTGTGCTCTACAAGAGGGCATCGAGCCCCTCAGT

GGGAGATATTTTGCCAACTGCCATGTGGAAGAGGTGCCTCCAGCTGCCCGAGACGACCGG

GCAGCCCATCGGCTATGGGAGGCCAGCAAGAGGCTGGCAGGGCTTGGGCCTGGGGAGGAT

GCTGAACCCGATGAAGACCCCCAGTCTGAGGACTCAGAGGCCCCATCTTCTCTAAGCACC

CCCCACCCTGAGGAGCCCACAGTTTCTCAACCTTACCCCAGCCCTCAGAGCTCACCAGAT

TTGTCTAAGATGACGCACCGAATTCAGGCTAAAGTTGAGCCTGAGATCCAGCTCTCCTAA

CCCTCAGGCCAGGATGCTTGCCATGGCACTTCATGGTCCTTGAAAACCTCGGATGTGTGC

GAGGCCATGCCCTGGACACTGACGGGTTTGTGATCTTGACCTCCGTGGTTACTTTCTGGG

GCCCCAAGCTGTGCCCTGGACATCTCTTTTCCTGGTTGAAGGAATAATGGGTGATTATTT

CTTCCTGAGAGTGACAGTAACCCCAGATGGAGAGATAGGGGTATGCTAGACACTGTGCTT

CTCGGAAATTTGGATGTAGTATTTTCAGGCCCCACCCTTATTGATTCTGATCAGCTCTGG

AGCAGAGGCAGGGAGTTTGCAATGTGATGCACTGCCAACATTGAGAATTAGTGAACTGAT

CCCTTTGCAACCGTCTAGCTAGGTAGTTAAATTACCCCCATGTTAATGAAGCGGAATTAG

GCTCCCGAGCTAAGGGACTCGCCTAGGGTCTCACAGTGAGTAGGAGGAGGGCCTGGGATC

TGAACCCAAGGGTCTGAGGCCAGGGCCGACTGCCGTAAGATGGGTGCTGAGAAGTGAGTC

AGGGCAGGGCAGCTGGTATCGAGGTGCCCCATGGGAGTAAGGGGACGCCTTCCGGGCGGA

TGCAGGGCTGGGGTCATCTGTATCTGAAGCCCCTCGGAATAAAGCGCGTTGACCGCCAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.55150_mRNA_1 gi\|17068414\|gb\|BC017586.1\|BC017586 Homo sapiens clone
MGC:26610 IMAGE:4837506 polyA = 3
AGCGGTGGAGAAAAGGCAGAACCAGAGTAGAGATTGACAGTGAGCTGAGCCAATCAGGCT

GTGAATCTGCAGCAGTGATCCCAGGTCCTCCAATTAATACTAAGAGAGTGGACCAGGGCC

CCTGAGGAAGACAGATGGCAGGGACAGCGCGCCATGACCGAGAGATGGCGATCCAGGCCA

AGAAAAAGCTCACCACGGCCACCAACCCCATTGAAAGACTCCGACTGCAGTGCCTGGCCA

GGGGCTCTGCTGGGATCAAAGGACTTGGCAGAGTGTTTAGAATTATGGATGACGATAATA

ATCGAACCCTTGATTTTAAAGAATTTATGAAAGGGTTAAATGATTATGCTGTGGTCATGG

AAAAAGAAGAGGTGGAAGAACTTTTCCGGAGGTTTGATAAAGATGGAAATGGAACAATAG

ACTTCAATGAATTTCTTCTCACATTAAGACCTCCAATGTCCAGAGCCAGAAAAGAGGTAA

TCATGCAAGCTTTTAGAAAGTTAGACAAGACTGGAGATGGTGTTATAACAATCGAAGACC

TTCGTGAAGTATATAATGCAAAACACCACCCAAAGTACCAGAATGGGGAATGGAGTGAGG

AACAAGTATTTAGGAAATTTCTGGATAACTTTGATTCACCCTATGACAAAGATGGATTGG

TGACCCCTGAGGAGTTCATGAACTACTATGCAGGTGTGAGCGCATCCATTGACACTGATG

TGTACTTCATCATCATGATGAGAACCGCCTGGAAGCTTTAAGCACATGACCTGGGGACCA

GGCCCTGGGACAGCCATGTGGCTCCAAATGACTAAATGTCAGCTCAAAAACCAGAATCGT

ATTTGATTTCACACTCATCCTAATGTTTTTTTCTGTGTCAAAATATTGCATTTTCTGGGG

CCAAAAAACAGGCAGAAATAAAAGACATTGAGTAGTCAAAAAAAAAAAAAAAA

>Hs.170177_contig3
AI620495\|AW291989\|AA780896\|AA976262\|AI298326\|BF111862\|AW591523\|AI922518\|AI4
80280\|BF589437\|AA600354\|AI886238\|AA035599\|H90049\|BF112011\|N52601\|AI570965\|A
1565367\|AW768847\|H90073\|BE504361\|N45292\|AI632075\|AA679729\|AW168052\|AI978827
\|AI968410\|AI669255\|N45300\|AI651256\|AI698970\|AI521256\|AW078614\|AI802070\|AI88
5947\|AI342534\|AI653624\|AW243936\|T16586\|R15989\|AI289789\|AI871636\|AI718785\|AW
148847 polyA = 2 polyA = 3
TAGAGCATTAAAATAACTATCAGGCAGAAGAATCTTTCTTCTCGCCTAGGATTTCAGCCA

TGCGCGCGCTCTCTCTCTTTCTCTCTCTTTTCCTCTCTCTCCCTCTTTCTAGCCTGGGGC

TTGAATTTGCATGTCTAATTCATTTACTCACCATATTTGAATTGGCCTGAACAGATGTAA

ATCGGGAAGGATGGGAAAAACTGCAGTCATCAACAATGATTAATCAGCTGTTGCAGGCAG

TGTCTTAAGGAGACTGGTAGGAGGAGGCATGGAAACCAAAAGGCCGTGTGTTTAGAAGCC

TAATTGTCACATCAAGCATCATTGTCCCCATGCAACAACCACCACCTTATACATCACTTC

CTGTTTTAAGCAGCTCTAAAACATAGACTGAAGATTTATTTTTAATATGTTGACTTTATT

TCTGAGCAAAGCATCGGTCATGTGTGTATTTTTTCATAGTCCCACCTTGGAGCATTTATG

TAGACATTGTAAATAAATTTTGTGCAAAAAGGACTGGAAAAATGAACTGTATTATTGCAA

TTTTTTTTTGTAAAAGTAGCAGTTTGGTATGAGTTGGCATGCATACAAGATTTACTAAGT

GGGATAAGCTAATTATACTTTTTGTTGTGGATAAACAAATGCTTGTTGATAGCCTTTTTC

TATCAAGAAACCAAGGAGCTAATTATTAATAACAATCATTGCACACTGAGTCTTAGCGTT

TCTGATGGAAACAGTTTGGATTGTATAATAACGCCAAGCCCAGTTGTAGTCGTTTGAGTG

CAGTAATGAAATCTGAATCTAAAATAAAAACAAGATTATTTTTGTCAAAAAAAAAAAAAA

AAAAAAAAAA

>Hs.184601_mRNA_5 gi\|4426639\|gb\|AF104032.1\|AF104032 Homo sapiens polyA = 2
GCGGCGCGCACACTGCTCGCTGGGCCGCGGCTCCCGGGTGTCCCAGGCCCGGCCGGTGCG

CAGAGCATGGCGGGTGCGGGCCCGAAGCGGCGCGCGCTAGCGGCGCCGGCGGCCGAGGAG

AAGGAAGAGGCGCGGGAGAAGATGCTGGCCGCCAAGAGCGCGGACGGCTCGGCGCCGGCA

GGCGAGGGCGAGGGCGTGACCCTGCAGCGGAACATCACGCTGCTCAACGGCGTGGCCATC

ATCGTGGGGACCATTATCGGCTCGGGCATCTTCGTGACGCCCACGGGCGTGCTCAAGGAG

GCAGGCTCGCCGGGGCTGGCGCTGGTGGTGTGGGCCGCGTGCGGCGTCTTCTCCATCGTG

GGCGCGCTCTGCTACGCGGAGCTCGGCACCACCATCTCCAAATCGGGCGGCGACTACGCC

TACATGCTGGAGGTCTACGGCTCGCTGCCCGCCTTCCTCAAGCTCTGGATCGAGCTGCTC

ATCATCCGGCCTTCATCGCAGTACATCGTGGCCCTGGTCTTCGCCACCTACCTGCTCAAG

CCGCTCTTCCCCACCTGCCCGGTGCCCGAGGAGGCAGCCAAGCTCGTGGCCTGCCTCTGC

GTGCTGCTGCTCACGGCCGTGAACTGCTACAGCGTGAAGGCCGCCACCCGGGTCCAGGAT

GCCTTTGCCGCCGCCAAGCTCCTGGCCCTGGCCCTGATCATCCTGCTGGGCTTCGTCCAG

ATCGGGAAGGGTGATGTGTCCAATCTAGATCCCAACTTCTCATTTGAAGGCACCAAACTG

GATGTGGGGAACATTGTGCTGGCATTATACAGCGGCCTCTTTGCCTATGGAGGATGGAAT

TACTTGAATTTCGTCACAGAGGAAATGATCAACCCCTACAGAAACCTGCCCCTGGCCATC

ATCATCTCCCTGCCCATCGTGACGCTGGTGTACGTGCTGACCAACCTGGCCTACTTCACC

ACCCTGTCCACCGAGCAGATGCTGTCGTCCGAGGCCGTGGCCGTGGACTTCGGGAACTAT

CACCTGGGCGTCATGTCCTGGATCATCCCCGTCTTCGTGGGCCTGTCCTGCTTCGGCTCC

GTCAATGGGTCCCTGTTCACATCCTCCAGGCTCTTCTTCGTGGGGTCCCGGGAAGGCCAC

CTGCCCTCCATCCTCTCCATGATCCACCCACAGCTCCTCACCCCCGTGCCGTCCCTCGTG

TTCACGTGTGTGATGACGCTGCTCTACGCCTTCTCCAAGGACATCTTCTCCGTCATCAAC

TTCTTCAGCTTCTTCAACTGGCTCTGCGTGGCCCTGGCCATCATCGGCATGATCTGGCTG

CGCCACAGAAAGCCTGAGCTTGAGCGGCCCATCAAGGTGAACCTGGCCCTGCCTGTGTTC

TTCATCCTGGCCTGCCTCTTCCTGATCGCCGTCTCCTTCTGGAAGACACCCGTGGAGTGT

GGCATCGGCTTCACCATCATCCTCAGCGGGCTGCCCGTCTACTTCTTCGGGGTCTGGTGG

AAAAACAAGCCCAAGTGGCTCCTCCAGGGCATCTTCTCCACGACCGTCCTGTGTCAGAAG

CTCATGCAGGTGGTCCCCCAGGAGACATAGCCAGGAGGCCGAGTGGCTGCCGGAGGAGCA

TGCGCAGAGGCCAGTTAAAGTAGATCACCTCCTCGAACCCACTCCGGTTCCCCGCAACCC

ACAGCTCAGCTGCCCATCCCAGTCCCTCGCCGTCCCTCCCAGGTCGGGCAGTGGAGGCTG

CTGTGAAAACTCTGGTACGAATCTCATCCCTCAACTGAGGGCCAGGGACCCAGGTGTGCC

TGTGCTCCTGCCCAGGAGCAGCTTTTGGTCTCCTTGGGCCCTTTTTCCCTTCCCTCCTTT

GTTTACTTATATATATATTTTTTTTAAACTTAAATTTTGGGTCAACTTGACACCACTAAG

ATGATTTTTTAAGGAGCTGGGGGAAGGCAGGAGCCTTCCTTTCTCCTGCCCCAAGGGCCC

AGACCCTGGGCAAACAGAGCTACTGAGACTTGGAACCTCATTGCTACGACAGACTTGCAC

TGAAGCCGGACAGCTGCCCAGACACATGGGCTTGTGACATTCGTGAAAACCAACCCTGTG

GGCTTATGTCTCTGCCTTAGGGTTTGCAGAGTGGAAACTCAGCCGTAGGGTGGCACTGGG

AGGGGGTGGGGGATCTGGGCAAGGTGGGTGATTCCTCTCAGGAGGTGCTTGAGGCCCCGA

TGGACTCCTGACCATAATCCTAGCCCTGAGACACCATCCTGAGCCAGGGAACAGCCCCAG

GGTTGGGGGGTGCCGGCATCTCCCCTAGCTCACCAGGCCTGGCCTCTGGGCAGTGTGGCC

TCTTGGCTATTTCTGTGTCCAGTTTTGGAGGCTGAGTTCTGGTTCATGCAGACAAAGCCC

TGTCCTTCAGTCTTCTAGAAACAGAGACAAGAAAGGCAGACACACCGCGGCCAGGCACCC

ATGTGGGCGCCCACCCTGGGCTCCACACAGCAGTGTCCCCTGCCCCAGAGGTCGCAGCTA

CCCTCAGCCTCCAATGCATTGGCCTCTGTACCGCCCGGCAGCCCCTTCTGGCCGGTGCTG

GGTTCCCACTCCCGGCCTAGGCACCTCCCCGCTCTCCCTGTCACGCTCATGTCCTGTCCT

GGTCCTGATGCCCGTTGTCTAGGAGACAGAGCCAAGCACTGCTCACGTCTCTGCCGCCTG

CGTTTGGAGGCCCCTGGGCTCTCACCCAGTCCCCACCCGCCTGCAGAGAGGGAACTAGGG

CACCCCTTGTTTCTGTTGTTCCCGTGAATTTTTTTCGCTATGGGAGGCAGCCGAGGCCTG

GCCAATGCGGCCCACTTTCCTGAGCTGTCGCTGCCTCCATGGCAGCAGCCAAGGACCCCC

AGAACAAGAAGACCCCCCCGCAGGATCCCTCCTGAGCTCGGGGGGCTCTGCCTTCTCAGG

CCCCGGGCTTCCCTTCTCCCCAGCCAGAGGTGGAGCCAAGTGGTCCAGCGTCACTCCAGT

GCTCAGCTGTGGCTGGAGGAGCTGGCCTGTGGCACAGCCCTGAGTGTCCCAAGCCGGGAG

CCAACGAAGCCGGACACGGCTTCACTGACCAGCGGCTGCTCAAGCCGCAAGCTCTCAGCA

AGTGCCCAGCGGAGCCTGCCGCCCCCACCTGGGCACCGGGACCCCCTCACCATCCAGTGG

GCCCGGAGAAACCTGATGAACAGTTTGGGGACTCAGGACCAGATGTCCGTCTCTCTTGCT

TGAGGAATGAAGACCTTTATTCACCCCTGCCCCGTTGCTTCCCGCTGCACATGGACAGAC

TTCACAGCGTCTGCTCATAGGACCTGCATCCTTCCTGGGGACGAATTCCACTCGTCCAAG

GGACAGCCCACGGTCTGGAGGCCGAGGACCACCAGCAGGCAGGTGGACTGACTGTGTTGG

GCAAGACCTCTTCCCTCTGGGCCTGTTCTCTTGGCTGCAAATAAGGACAGCAGCTGGTGC

CCCACCTGCCTGGTGCATTGCTGTGTGAATCCAGGAGGCAGTGGACATCGTAGGCAGCCA

CGGCCCCGGGTCCAGGAGAAGTGCTCCCTGGAGGCACGCACCACTGCTTCCCACTGGGGC

CGGCGGGGCCCACGCACGACGTCAGCCTCTTACCTTCCCGCCTCGGCTAGGGGTCCTCGG

GATGCCGTTCTGTTCCAACCTCCTGCTCTGGGACGTGGACATGCCTCAAGGATACAGGGA

GCCGGCGGCCTCTCGACGGCACGCACTTGCCTGTTGGCTGCTGCGGCTGTGGGCGAGCAT

GGGGGCTGCCAGCGTCTGTTGTGGAAAGTAGCTGCTAGTGAAATGGCTGGGGCCGCTGGG

GTCCGTCTTCACACTGCGCAGGTCTCTTCTGGGCGTCTGAGCTGGGGTGGGAGCTCCTCC

GCAGAAGGTTGGTGGGGGGTCCAGTCTGTGATCCTTGGTGCTGTGTGCCCCACTCCAGCC

TGGGGACCCCACTTCAGAAGGTAGGGGCCGTGTCCCGCGGTGCTGACTGAGGCCTGCTTC

CCCCTCCCCCTCCTGCTGTGCTGGAATTCCACAGGGACCAGGGCCACCGCAGGGGACTGT

CTCAGAAGACTTGATTTTTCCGTCCCTTTTTCTCCACACTCCACTGACAAACGTCCCCAG

CGGTTTCCACTTGTGGGCTTCAGGTGTTTTCAAGCACAACCCACCACAACAAGCAAGTGC

ATTTTCAGTCGTTGTGCTTTTTTGTTTTGTGCTAACGTCTTACTAATTTAAAGATGCTGT

CGGCACCATGTTTATTTATTTCCAGTGGTCATGCTCAGCCTTGCTGCTCTGCGTGGCGCA

GGTGCCATGCCTGCTCCCTGTCTGTGTCCCAGCCACGCAGGGCCATCCACTGTGACGTCG

GCCGACCAGGCTGGACACCCTCTGCCGAGTAATGACGTGTGTGGCTGGGACCTTCTTTAT

TCTGTGTTAATGGCTAACCTGTTACACTGGGCTGGGTTGGGTAGGGTGTTCTGGCTTTTT

TGTGGGGTTTTTATTTTTAAAGAAACACTCAATCATCCTAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.351972_singlet1 AA865917 polyA = 2 polyA = 3
GGGACTTGGAAAGGGGAACTGGGATTTGGGGAGGGGCTGGAGGACTTCCGCACGCTTCCA

CCTCCTTCGACCTCCACTGCGCCCCACCTCCCTGCCTGTGTGTGTTATTTCAAAGGAAAA

GAACAAAAGGAATAAATTTTCTAAGCTCTTTAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.5366_mRNA_2 gi\|15277845\|gb\|BC012926.1\|BC012926 Homo sapiens clone
MGC: 16817 IMAGE:3853503 polyA = 3
GCAGGCTCTGCCTGTGGCCACTAGCAGAGAAGCTGCTGTCCTTCCACCACCAGCACCGGA

CCACCTGCTCCAAGACCAGCCTCCTGGGGGGACCAGGCACCCGGCCTTCACTGGCACCCA

GGGAGCCGTCCTCAGCAGCGTCAACATGTCAAGGCCCAGCAGCAGAGCCATTTACTTGCA

CCGGAAGGAGTACTCCCAGAACCTCACCTCAGAGCCCACCCTCCTGCAGCACAGGGTGGA

GCACTTGATGACATGCAAGCAGGGGAGTCAGAGAGTCCAGGGGCCCGAGGATGCCTTGCA

GAAGCTGTTCGAGATGGATGCACAGGGCCGGGTGTGGAGCCAAGACTTGATCCTGCAGGT

CAGGGACGGCTGGCTGCAGCTGCTGGACATTGAGACCAAGGAGGAGCTGGACTCTTACCG

CCTAGACAGCATCCAGGCCATGAATGTGGCGCTCAACACATGTTCCTACAACTCCATCCT

GTCCATCACCGTGCAGGAGCCGGGCCTGCCAGGCACTAGCACTCTGCTCTTCCAGTGCCA

GGAAGTGGGGGCAGAGCGACTGAAGACCAGCCTGCAGAAGGCTCTGGAGGAAGAGCTGGA

GCAAAGCAGACCTCGACTTGGAGGCCTTCAGCCAGGCCAGGACAGATGGAGGGGGCCTGC

TATGGAAAGGCCGCTCCCTATGGAGCAGGCACGCTATCTGGAGCCGGGGATCCCTCCAGA

ACAGCCCCACCAGAGGACCCTAGAGCACAGCCTCCCACCATCCCCAAGGCCCCTGCCACG

CCACACCAGTGCCCGAGAACCAAGTGCCTTTACTCTGCCTCCTCCAAGGCGGTCCTCTTC

CCCCGAGGACCCAGAGAGGGACGAGGAAGTGCTGAACCATGTCCTAAGGGACATTGAGCT

GTTCATGGGAAAGCTGGAGAAGGCCCAGGCAAAGACCAGCAGGAAGAAGAAATTTGGGAA

AAAAAACAAGGACCAGGGAGGTCTCACCCAGGCACAGTACATTGACTGCTTCCAGAAGAT

CAAGTACAGCTTCAACCTCCTGGGAAGGCTGGCCACCTGGCTGAAGGAGACAAGTGCCCC

TGAGCTCGTACACATCCTCTTCAAGTCCCTGAACTTCATCCTGGCCAGGTGCCCTGAGGC

TGGCCTAGCAGCCCAAGTGATCTCACCCCTCCTCACCCCTAAAGCTATCAACCTGCTACA

GTCCTGTCTAAGCCCACCTGAGAGTAACCTTTGGATGGGGTTGGGCCCAGCCTGGACCAC

TAGCCGGGCCGACTGGACAGGCGATGAGCCCCTGCCCTACCAACCCACATTCTCGGATGA

CTGGCAACTTCCAGAGCCCTCCAGCCAAGCACCCTTAGGATACCAGGACCCTGTTTCCCT

TCGGCGGGGAAGTCATAGGTTAGGGAGCACCTCACACTTTCCTCAGGAGAAGACACACAA

CCATGACCCTCAGCCTGGGGACCCCAACTCCAGGCCCTCCAGCCCCAAACCTGCCCAGCC

AGCCCTGAAAATGCAAGTCTTGTACGAGTTTGAAGCTAGGAACCCACGGGAACTGACTGT

GGTCCAGGGAGAGAAGCTGGAGGTTCTGGACCACAGCAAGCGGTGGTGGCTGGTGAAGAA

TGAGGCGGGACGGAGCGGCTACATTCCAAGCAACATCCTGGAGCCCCTACAGCCGGGGAC

CCCTGGGACCCAGGGCCAGTCACCCTCTCGGGTTCCAATGCTTCGACTTAGCTCGAGGCC

TGAAGAGGTCACAGACTGGCTGCAGGCAGAGAACTTCTCCACTGCCACGGTGAGGACACT

TGGGTCCCTGACGGGGAGCCAGCTACTTCGCATAAGACCTGGGGAGCTACAGATGCTATG

TCCACAGGAGGCCCCACGAATCCTGTCCCGGCTGGAGGCTGTCAGAAGGATGCTGGGGAT

AAGCCCTTAGGCACCAGCTTAGACACCTCCAAGAACCAGGCCCCGCTGATGCAAGATGGC

AGATCTGATACCCATTAGAGCCCCGAGAATTCCTCTTCTGGATCCCAGTTTGCAGCAAAC

CCCACACCCCAGCTCACACAGCAAAAACAATGGACAGGCCCAGAGGGTGAAGCAAACAGT

GTCCCTTCTGGCTGTGTTGGAGCCTCCCCAGTAACCACCTATTTATTTTACCTCTTTCCC

AAACCTGGAGCATTTATGCCTAGGCTTGTCAAGAATCTGTTCAGTCCCTCTCCTTCTCAA

TAAAAGCATCTTCAAGCTTGAAAAAAAAAAAAAAA

>Hs.18140_contig1
AI685931\|AA410954\|T97707 AA706873\|AI911572 AW614616\|AA548520\|AW027764\|BF511
251\|AI914294\|AW151688 polyA = 1 polyA = 1
CCTTCCATTGAATTCCACCAGACACATTCAGGTTANCTTCGTAATGTCTTCATATGAGTA

TCAATCAACACCTTCCCCAACTCAATTGTACTAGGTTGTAGAGCACAAGGATGGTCTCGT

GCTGCTCTGTGGCACCTGTGCCTACACTGCTCTGAGCTTTGAGGAGGCTGCTCTCTTTGC

TGACCCCATGATCTTTTCTGCCCTTCTGTTAAGGGCATTGGCCACAGCAACGGGGCAAAT

GCCCCAAGCTGGCTGTAAGTGACCCATCCCTTTGGCTCCCATGATTAGACCAAGGAGAGG

CATGGGGTCCAGCTGAGCCATTCAGAACCATTCCTTAGCATTTTCCACTCAAAGGTTAGA

GATGAGATTTTCTCTTCCCAAGGCTACCTCTGGCCATGGTTCCAGCTTCATGGGGGCAAT

GGGATTAGGAAAATGAGGTCAACCTGCAAAGGAAAGCAGATGCAAGAGATGGAGACAGAA

TGGGGGTGTCCTGGGGATCTTGGAGCCTGAATTCATTGGCACAAAAGGCAGCAGCATCCT

CACTGTATCTGCAGTCCATTTGGACTCAATAAAAACTTTGAAAGTCACATGTGTTATGGA

ATTCCTTCTCAGTGACACATTCATCTGTGCTCAGTTGTCCCAGCAAGGGTCAGCCCCTCA

TACCCCTGCAGCATCCGCTGCTATGAAGCAGAGCTGTAAACGCCCTCCCTGTGTATAGGA

AAAGCTACATGGAGCAAATCCTCCTGCCTGAAGAAGTGCATCTCAGCATCACTTCAGCTG

TCGGGGCATTTGTGGGGAGAACCAGACCACCTCTGCGGAAGGCAGCAGACCCTCTTCCAG

CCATGGATGGAGTTGAATTCTCTATAAACGGTTCACCAGCAAACCACCAATACATTCCAT

TGTTTGCCTAGAGAGAAATTTAAAAATATVATAAATGTTCACTTAT

>Hs.133196_contig2
BF224381BE467992\|AW137689\|AI695045\|AW207361\|BF445141\|AA405473 polyA = 2 WARN
polyA = 3
TGCGGCCGCGGCATGAAAGGCGGCGAGGAGAGGCAGCACTGCTGCTCTTGACTTCTGAGC

AGGGCTTAGAGAGCCTGCCCCGGCTTAAGCCGAGCTGCTGGTGCTGACCCTGAGCGCCGA

GTCCGCGAGCTCTGAGTCCGGAGCCTCCCAGCCGTGGAGCCGTGGGATGAGGGGGGCGTT

GGGGGACAGGGCAAAGTCGATCTTGGTTGTACAGCCGCCCGATCCTAGCGCGGAGCTGCG

AGCCTGACCGGCCGCGTCTGGCATGGTCAGAGAAAGAATTTTCTTTTCCCAACTCCGGCT

TTTGGTTTTGTGTGTCCACCTTGCGCAACTCCGGAGCCAGCCGACCCCACATGGATTCTC

AACAGGTGGCCGGCACATCTTCTGAGCCTCGCTCTCTCATCTGAAAGTGGAGTGTAAGTC

CAAGAAGATTCATTTAGACAAAGAAGGTGGAAAAAAAGGACTTTCTGGGCCAGCAAGTCG

GATGACCACCCTCCAAGGGGCAGAGGAGGGCCCATTTTGTGAAGAAGAAATCAACTACCC

GGAAAACGCCACAGGAGGACATGTTTCTGCAGATGTAGTTGCCCTAGAAACAGAAGAGTA

TGGGGGTGTGAATGTCTTCTCTTTTGGGGGCAAACACTATGTCCTTTTCTTTTTCTAGAT

ACAGTTAATTCCTGGAAATTTTAGCGAGTTTGTTCTTGTGGATATTTTGAACAATAAAGA

GTGAAAATCAAAAAAA

>Hs.63325_mRNA_5 gi\|15451939\|ref\|NM_019894.1\|Homo sapiens transmembrane
protease, serine 4 (TMPRSS4), mRNA polyA = 3
CCCAATCACTCCTGGAATACACAGAGAGAGGCAGCAGCTTGCTCAGCGGACAAGGATGCT

GGGCGTGAGGGACCAAGGCCTGCCCTGCACTCGGGCCTCCTCCAGCCAGTGCTGACCAGG

GACTTCTGACCTGCTGGCCAGCCAGGACCTGTGTGGGGAGGCCCTCCTGCTGCCTTGGGG

TGACAATCTCAGCTCCAGGCTACAGGGAGACCGGGAGGATCACAGAGCCAGCATGTTACA

GGATCCTGACAGTGATCAACCTCTGAACAGCCTCGATGTCAAACCCCTGCGCAAACCCCG

TATCCCCATGGAGACCTTCAGAAAGGTGGGGATCCCCATCATCATAGCACTACTGAGCCT

GGCGAGTATCATCATTGTGGTTGTCCTCATCAAGGTGATTCTGGATAAATACTACTTCCT

CTGCGGGCAGCCTCTCCACTTCATCCCGAGGAAGCAGCTGTGTGACGGAGAGCTGGACTG

TCCCTTGGGGGAGGACGAGGAGCACTGTGTCAAGAGCTTCCCCGAAGGGCCTGCAGTGGC

AGTCCGCCTCTCCAAGGACCGATCCACACTGCAGGTGCTGGACTCGGCCACAGGGAACTG

GTTCTCTGCCTGTTTCGACAACTTCACAGAAGCTCTCGCTGAGACAGCCTGTAGGCAGAT

GGGCTACAGCAGCAAACCCACTTTCAGAGCTGTGGAGATTGGCCCAGACCAGGATCTGGA

TGTTGTTGAAATCACAGAAAACAGCCAGGAGCTTCGCATGCGGAACTCAAGTGGGCCCTG

TCTCTCAGGCTCCCTGGTCTCCCTGCACTGTCTTGCCTGTGGGAAGAGCCTGAAGACCCC

CCGTGTGGTGGGTGGGGAGGAGGCCTCTGTGGATTCTTGGCCTTGGCAGGTCAGCATCCA

GTACGACAAACAGCACGTCTGTGGAGGGAGCATCCTGGACCCCCACTGGGTCCTCACGGC

AGCCCACTGCTTCAGGAAACATACCGATGTGTTCAACTGGAAGGTGCGGGCAGGCTCAGA

CAAACTGGGCAGCTTCCCATCCCTGGCTGTGGCCAAGATCATCATCATTGAATTCAACCC

CATGTACCCCAAAGACAATGACATCGCCCTCATGAAGCTGCAGTTCCCACTCACTTTCTC

AGGCACAGTCAGGCCCATCTGTCTGCCCTTCTTTGATGAGGAGCTCACTCCAGCCACCCC

ACTCTGGATCATTGGATGGGGCTTTACGAAGCAGAATGGAGGGAAGATGTCTGACATACT

GCTGCAGGCGTCAGTCCAGGTCATTGACAGCACACGGTGCAATGCAGACGATGCGTACCA

GGGGGAAGTCACCGAGAAGATGATGTGTGCAGGCATCCCGGAAGGGGGTGTGGACACCTG

CCAGGGTGACAGTGGTGGGCCCCTGATGTACCAATCTGACCAGTGGCATGTGGTGGGCAT

CGTTAGCTGGGGCTATGGCTGCGGGGGCCCGAGCACCCCAGGAGTATACACCAAGGTCTC

AGCCTATCTCAACTGGATCTACAATGTCTGGAAGGCTGAGCTGTAATGCTGCTGCCCCTT

TGCAGTGCTGGGAGCCGCTTCCTTCCTGCCCTGCCCACCTGGGGATCCCCCAAAGTCAGA

CACAGAGCAAGAGTCCCCTTGGGTACACCCCTCTGCCCACAGCCTCAGCATTTCTTGGAG

CAGCAAAGGGCCTCAATTCCTGTAAGAGACCCTCGCAGCCCAGAGGCGCCCAGAGGAAGT

CAGCAGCCCTAGCTCGGCCACACTTGGTGCTCCCAGCATCCCAGGGAGAGACACAGCCCA

CTGAACAAGGTCTCAGGGGTATTGCTAAGCCAAGAAGGAACTTTCCCACACTACTGAATG

GAAGCAGGCTGTCTTGTAAAAGCCCAGATCACTGTGGGCTGGAGAGGAGAAGGAAAGGGT

CTGCGCCAGCCCTGTCCGTCTTCACCCATCCCCAAGCCTACTAGAGCAAGAAACCAGTTG

TAATATAAAATGCACTGCCCTACTGTTGGTATGACTACCGTTACCTACTGTTGTCATTGT

TATTACAGCTATGGCCACTATTATTAAAGAGCTGTGTAACATCAAAAAAAAAAAAAAAAA

AAAA

>Hs.250692_mRNA_2 gi\|184223\|gb\|M95585.1\|HUMHLF Human hepatic leukemia
factor (HLF) mRNA, complete cds polyA = 3
TTTTTCAATTTTGAACATTTTGCAAAACGAGGGGTTCGAGGCAGGTGAGAGCATCCTGCA

CGTCGCCGGGGAGCCCGCGGGCACTTGGCGCGCTCTCCTGGGACCGTCTGCACTGGAAAC

CCGAAAGTTTTTTTTTAATATATATTTTTATGCAGATGTATTTATAAAGATATAAGTAAT

TTTTTTCTTCCCTTTTCTCCACCGCCTTGAGAGCGAGTACTTTTGGCAAAGGACGGAGGA

AAAGCTCAGCAACATTTTAGGGGGCGGTTGTTTCTTTCTTTCTTATTTCTTTTTTAAGGG

GAAAAAATTTGAGTGCATCGCGATGGAGAAAATGTCCCGACCGCTCCCCCTGAATCCCAC

CTTTATCCCGCCTCCCTACGGCGTGCTCAGGTCCCTGCTGGAGAACCCGCTGAAGCTCCC

CCTTCACCACGAAGACGCATTTAGTAAAGATAAAGACAAAGAAAAGAAGCTGGATGATGA

GAGTAACAGCCCGACGGTCCCCCAGTCGGCATTCCTGGGGCCTACCTTATGGGACAAAAC

CCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTC

AGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCT

GCAGCCAGCTTCCTCGGCTGCCCCCTCGGTCATGGACCTCAGCAGCCGGGCCTCTGCACC

CCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCT

GTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGT

GGGTTATGAGCCAGACCCAGCAGATCTTGCCCTTTCCAGCATCCCTGGCCAGGAAATGTT

TGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAA

AGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAG

AAAGAACAACATGGCAGCCAAGCGCTCCCGCGACGCCCGGAGGCTGAAAGAGAACCAGAT

CGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGA

CTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAAGTATGAGGCCAGGCACGG

GCCCCTGTAGGATGGCATTTTTGCAGGCTGGCTTTGGAATAGATGGACAGTTTGTTTCCT

GTCTGATAGCACCACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAA

ACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTGCGTGTATATGTGCTTGTG

CTCATGTGTGTGGTCAGCGGTATGTGCGTGTGCGTGTTCCTTTGCTCTTGCCATTTTAAG

GTAGCCCTCTCATCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTG

AGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACTCCTGCCTCCTCAGCTTTG

CTTCATGTTCGAGCTTACCTACTCTTCCAGGACTCTCTGCTTGGATTCACTAAAAAGGGC

CCTGGTAAAATAGTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCG

TAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACTACTCCGCAGCTCTAGTCC

TTTATAAGTTGCTTTCCTCTTACTTTCAGTTTTGGTGATAATCGTCTTCAAATTAAAGTG

CTGTTTAGATTTATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAAT

TCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACACAGAGTGTGTTTTTGCACT

GTCTGTACCTAAAGCAATAATCCTATTGTACGCTAGAGCATGCTGCCTGAGTATTACTAG

TGGACGTAGGATATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAA

AGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAGGAAGCAGAGGGAAATGGG

AGGTCTAAGGATGAGGGGTTAATTTATCAGTACATGAGCCAAAAACTGCGTCTTGGATTA

GCCTTTGACATTGATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCC

CCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTCAAAACAGTTACTTAAGAT

TCAGTTTTCCCACTTTTTGGTAATATATATATTTTTGTGAATTATACTTTGTTGTTTTTA

AAAAGAAAATCAGTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGT

GGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGCTTATGTTTCTTATTCTCT

GTTTGCTTTTGAACGTATGTGCTCTTATAAAGTGGACTTCTGAAAAATGAATGTAAAAGA

CACTGGTGTATCTCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTT

AAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTTTAATGTTTATACAGAGTA

ATTATAGGAAGTTCTTTTTTGTACAGTATTTTTCAGATATAAATACTGACAATGTATTTT

GGAAGACATATATTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTA

TATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAAGTGCTTGGGGGTTTTTGA

AGTCTTTAATATTTTAAGCCCTATCACTGACACATCAGCATGTTTTCTGCTTTAAATTAA

AATTTTATGACAGTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGC

TTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACGTCACCCAAAAGCACAAAA

TGGATTTTAGTCAAATATTTATTGGATGATACAGTGTTTTTTAGGAAAAGCATCTGCCAC

AAAAATGTTCACTTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAG

ACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGTTGATATCGGTGCTATGTG

TTTGGTTTATAATTTGATAGATGTTTGACTTTAAAGATGATTGTTCTTTTGTTTCATTAA

GTTGTAAAATGTCAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAA

ATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAGAGTATCTAATCCTTTAAT

GATCTGGTGGTCTCCTCGTCAATCCATCAGCAATGCTTCTCTCATAGTGTCATAGACTTG

GGAAACCCAACCAGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAA

CAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTCAGGTGAATAATAAAATCA

AAAACTTTTGCAATCTTAAGCAGAGATAAATAAAAGATAGCAATATGAGACACAGGTGGA

CGTAGAGTTGGCCTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAG

TCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATTGTGGAAGGATTGTAACAT

GGACCATCCAAATTTATGGCCGTATCAAATGGTAGCTGAAAAAACTATATTTGAGCACTG

GTCTCTCTTGGAATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAA

AAATAAAAAGATTCTAATAAAAAAA

>Hs.250726_singlet4 AW298545 polyA = 2 polyA = 3
TTCCTTCCCTCCCTCCNTTCCTCAGGAGCCGCCAGTCCCCAAGTTGGCTGTGGTTGGGCA

CCTGGTTTGGGTCCTGCAGAGCTGGGCTCAGGCCCTGGGCTCTGAACCTGTGAACCCTTG

CTGTGTTACGAAACTTTCCTTCCTCTGAGGGCCTTGAACCCTCTCCTTTTCTTCTTTTGG

GGGTGGGGGTTAACTTTATTTTCTCTTCCCTGTATCTGCCTCTCCCTTCCCTCAATTTCC

TGTTTTAAAACTGAATGGCACGAAATTGTTTTCCTCAACTCGGAGATTCCTGTATGGAGA

GAATCAATTTCTATATTTGCAATAAATTTCTTATTTAAAGCTAAAAAAAAAAAAAAAAA

>Hs.79217_mRNA_2 gi\|16306657\|gb\|BC001504.1\|BC001504 Homo sapiens
MGC:2273 IMAGE:3505512 polyA = 3 clone
GGCACGAGGGCCATCTGTGGGGGCTTTGGGCCAGGGGTCTCCGGACAGCATGAGCGTGGG

CTTCATCGGCGCTGGCCAGCTGGCTTTTGCCCTGGCCAAGGGCTTCACAGCAGCAGGCGT

CTTGGCTGCCCACAAGATAATGGCTAGCTCCCCAGACATGGACCTGGCCACAGTTTCTGC

TCTCAGGAAGATGGGGGTGAAGTTGACACCCCACAACAAGGAGACGGTGCAGCACAGTGA

TGTGCTCTTCCTGGCTGTGAAGCCACACATCATCCCCTTCATCCTGGATGAAATAGGCGC

CGACATTGAGGACAGACACATTGTGGTGTCCTGCGCGGCCGGCGTCACCATCAGCTCCAT

TGAGAAGAAGCTGTCAGCGTTTCGGCCAGCCCCCAGGGTCATCCGCTGCATGACCAACAC

TCCAGTCGTGGTGCGGGAGGGGGCCACCGTGTATGCCACAGGCACGCACGCCCAGGTGGA

GGACGGGAGGCTCATGGAGCAGCTGCTGAGCAGCGTGGGCTTCTGCACGGAGGTGGAAGA

GGACCTGATTGATGCCGTCACGGGGCTCAGTGGCAGCGGCCCCGCCTACGCATTCACAGC

CCTGGATGCCCTGGCTGATGGGGGCGTGAAGATGGGACTTCCAAGGCGCCTGGCAGTCCG

CCTCGGGGCCCAGGCCCTCCTGGGGGCTGCCAAGATGCTGCTGCACTCAGAACAGCACCC

AGGCCAGCTCAAGGACAACGTCAGCTCTCCTGGTGGGGCCACCATCCATGCCTTGCATGT

GCTGGAGAGTGGGGGCTTCCGCTCCCTGCTCATCAACGCTGTGGAGGCCTCCTGCATCCG

CACACGGGAGCTGCAGTCCATGGCTGACCAGGAGCAGGTGTCACCAGCCGCCATCAAGAA

GACCATCCTGGACAAGGTGAAGCTGGACTCCCCTGCAGGGACCGCTCTGTCGCCTTCTGG

CCACACCAAGCTGCTCCCCCGCAGCCTGGCCCCAGCGGGCAAGGATTGACACGTCCTGCC

TGACCACCATCCTGCCACCACCTTCTCTTCTCTTGTCACTAGGGGGACTAGGGGGTCCCC

AAAGTGGCCCACTTTCTGTGGCTCTGATCAGCGCAGGGGCCAGCCAGGGACATAGCCAGG

GAGGGGCCACATCACTTCCCACTGGAAATCTCTGTGGTCTGCAAGTGCTTCCCAGCCCAG

AACAGGGGTGGATTCCCCAACCTCAACCTCCTTTCTTCTCTGCTCCCAAACCATGTCAGG

ACCACCTTCCTCTAGAGCTCGGGAGCCCGGAGGGTCTTCACCCACTCCTACTCCAGTATC

AGCTGGCACGGGCTCCTTCCTGAGAGCAAAGGTCAAGGACCCCCTCTGTGAAGGCTCAGC

AGAGGTGGGATCCCACGCCCCCTCCCGGCCCCTCCCTGCCCTCCATTCAGGGAGAAACCT

CTCCTTCCCGTGTGAGAAGGGCCAGAGGGTCCAGGCATCCCAAGTCCAGCGTGAAGGGCC

ACAGCCCCTCTTGGCTGCCAAGCACGCAGATCCCATGGACATTTGGGGAAAGGGCTCCTT

GGGCTGCTGGTGAACTTCTGTGGCCACCACCTCCTGCTCCTGACCTCCCTGGGAGGGTGC

TATCAGTTCTGTCCTGGCCCTTTCAGTTTTATAAGTTGGTTTCCAGCCCCCAGTGTCCTG

ACTTCTGTCTGCCACATGAGGAGGGAGGCCCTGCCTGTGTGGGAGGGTGGTTACTGTGGG

TGGAATAGTGGAGGCCTTCAACTGATTAGACAAGGCCCGCCCACATCTTGGAGGGCATCT

GCCTTACTGATTAAAATGTCAATGTAATCTAAAAAAAAAAAAAAAAAA

>Hs.47986_mRNA_1 gi\|13279253\|gb\|BC004331.1\|BC004331 Homo sapiens
MGC:10940 IMAGE:3630835 polyA = 3
GATAAATGCGGAGGGACGGTCCAGCTTTAGCTCTCTGCTCGCCGCCGCCGCTGTCGCCGC

CACCTCCTCTGATCTACGAAAGTCATGTTACCCAACACCGGGAGGCTGGCAGGATGTACA

GTTTTTATCACAGGTGCAAGCCGTGGCATTGGCAAAGCTATTGCATTGAAAGCAGCAAAG

GATGGAGCAAATATTGTTATTGCTGCAAAGACCGCCCAGCCACATCCAAAACTTCTAGGC

ACAATCTATACTGCTGCTGAAGAAATTGAAGCAGTTGGAGGAAAGGCCTTGCCATGTATT

GTTGATGTGAGAGATGAACAGCAGATCAGTGCTGCAGTGGAGAAAGCCATCAAGAAATTT

GGAGCTTATACCATTGCTAAGTATGGTATGTCTATGTATGTGCTTGGAATGGCAGAAGAA

TTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCT

ATGGATATGCTGGGAGGACCTGGTATCGAAAGCCAGTGTAGAAAAGTTGATATCATTGCA

GATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTTTTACTGGCAACTTTGTCATTGAT

GAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGT

CATCCTTTGCAACCAGATTTCTTCTTAGATGAATACCCAGAAGCAGTTAGCAAGAAAGTG

GAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGAAACTGCAGCTGCAACCAAAACCA

CGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTT

GTTAAAGCCACTCAAGCAATCTATCTGTTTGAACTCTCCGGTGAAGATGGTGGCACGTGG

TTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGATATGGAGAGCCTTCTGATCAGGCA

GATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAA

CCAACAATGGCATTCATGTCAGGGAAATTGAAGATTAAAGGTAACATGGCCCTAGCAATC

AAATTGGAGAAGCTAATGAATCAGATGAATGCCAGACTGTGAAGGAAAATATAAAAAAAA

AGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTT

TCTTTCCTGTTATATTATAAGGATATGCACGTTTGTTCTGGAAAAGATAGAATTTGTCTC

TAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAATCAAACATAAGCTTCATTAAGTG

GGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATC

TCATTCACTGTCTTTCTCCAAGAAAAGTATTTTGGGCGGACAGTCAGATCAAGCAGTAAA

ATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAAGCTAGTCTGTTTTAAAATTTTTA

GTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTT

TAAAGAAAATCTTATATAGTACATTTTACAAAAATTATAAAAAATGAATTAGTACTGGCG

AGGACTAAATGAAACAATAATTTTTCATTTTGATAACTAGCTTTCCAGGTGGACTTAGCC

ATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATAT

GTTTAAATTGTCCTAAAACAAAATAATTTTCTCCCTAGGAGTATGCATTTGGCTACAGTG

TTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATGGGCTGAACTGTGTATCCCCCAAT

TCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCT

TTAAAGAGGTGACTTAAGTTCAAAGGAGGCTGTTAGTCTAATCCAACATGGTGTCCTTTG

GACATAAGAGATACCAGCAATGTGTGCACAGAACAAAGACCAGGAGAGGACACAGTGAGA

AGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTG

ATCTTTGACTTCTAATCTCCAGAATAGTGAGAAATAAATTTCTGTTGTTAAGCCGTCCAC

TGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAGGAGTTCAAGGCCAGCCTGGACAA

CATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGT

GGTATTTTATTATGGCAGCCCTAGCAAGCTAATACAGTGGTTTGAGAGGCTGGGAGGGTT

GAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTCATTTCAATCAGTTAAAAATACTT

GCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAA

TTTAGCTAATCCTGACATTTCTTAGATTCATAATGTTAGGAGCATTTAATCTGTATTTTA

CAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGACTAGCCCAAGGCCAACATTAACAA

GCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTC

TCCATCCAGGAATGGAGTCCATGTAATCAAAGTGAACTTAAAAATAGGACAGTTTCAACA

AGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCCAGTCAACGTGAGCAAGCGTGATT

ATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGA

TGTTAACCAATCTGCTGTGTCTACTATGCTGTTTCCTTGTTCCTGCTAGTGCTGCTTTAC

AAATGCAGACCATTCTATCATACCTGGCAGGGCTTCTGTTTTATTTTGTAGGCTGGATGC

TACCCAGTTCATGAATCGCTAATAAAAGCCAATTAGATCTTTAAAAAAAAAAAAAAAAAA

AAA

>Hs.94367_mRNA_1 gi\|10440200\|dbj\|AK027147.1\|AK027147 Homo sapiens cDNA
FLJ23494 fis, clone LNG01885 polyA = 3
TATTAAAAGTACCCCATGGATGGACCTCCAAATGAGTTTAGGGTAATTGCGCTTAAAATA

TTAGGACCAAAGTACATTTATTTTATAGATGGAGGAGGGGAGGAGACGAGTGGGGACCAG

CTTGACATCCAGTCTTCACCTGGACATATGGAAAGAACAAATGTGCGATCTGCTCGTTCC

CTCTGAAGGTCTCTGTTACGTATTTCCTCCTCTCCTCCAGAGCATAATAACCAATGACTG

CTCTCAGAAAGGTACTGTGACCACCACTTGCTTGGCTCTCCAACTTCCTCCCCCATTTCC

CTCTTGACTCCTGTTTGCCATAACACCTTCTGTCCCCTAGCCTTGCCTCAGGTCCCCGAC

GAATCCTGCCCTTAATCTGTGGGGGTGGTAGGTGGCACTGGTTTGAAGAGCTTACTGGAT

CTCCCTCAGTGAGTCAGCCTGGAGTTGTGTTTGAAAACCACAGGCCCTGACTGTGGCTGT

AAGACCTCCCAGACACCACCTGCTGCTGCCTATCATCATCTTCAGGTGCTGGGCTCCCCT

GTGGGCCTCGTCTGCCCGCCCTCTGCTGCAGCTGTCCCATGGGCGCCCGCCCTCTCTGAC

ACCACAAGAGAGCCCATCTAGATTCCAGGAAAAAACTCATCTTTATTTGCCTTCTTCCCA

CTGAAGGTAAAAGCAACATTAATAACCACAACAAATACTTAGTGAGTGCTTACTATTATT

CATTTAATTGTAGGCCCTTCCATCCCTGGCCATGATGAGAGACATGCCATAGCTTACTCC

TAAAGAGACCTGAGGACACACGTGCACAAACATATTGGGCATATCATCAATGGCATCAAA

ACTGATTTTCCCTGTCTACCCAGAACAGGCCTGAGGGAGAGGGAAAAGCGGATACCCACC

TGTGTCGCTGTTTGCGTGCCAAGTCCAGGAACAGTCCATACAGCCCTGCTGCATCCCACG

ACGCTGTCACAAAGCAGGAGTTCATCCGAGGCCAAGGTATGGAGAAACTGAGGCCCAGAA

ATTGATGTCCAGAATGCTTTGCTCTTAGCCACTGTACTATTATGGCATATTTTATCTTTA

TGTATTGCATCATTTCATGGATTCAAGTTTATCAATGTCCTTTGACAAGTTTAAAAATCT

GTCTGCTAAAATCTATCAAATACATTAAGGAAAAGTCCCACTTGGCACATCTCCCACACC

AGATGTTAATTATTCATACTGCATGACTGAGGATTTTGGAGGCAGAGAGAGATTCATCTG

CAATATTTGGAACACCAATGGAGGTCTATGTCAACACAGAATTTATACAGCAGCTGGTGC

TAGTCAGAGCTAATGACAGAATTTCAGTTTAATAAAAAGACCCCCAACTGAGCACACCAT

CTTGAAAAAAGTATACTTATCAAACAGCTTTCAATCAGTTCAAGAGAGACACCTTAATTG

GGGAGAGGAAGAATTGCAGAGTAGTTTGTAATCATGCCAATTCCAGATCAATAACTGCAT

GTCTGTTCTTTGGTAGAAATAGCTTTTGCTTTATATTAAGTAATCACATATATATTCTCT

CTATTTGGATAAGGAAACCTTCGCTTTATTTGACAATGTATAATGATATACTCTTCTAAT

TCACCTCTGTGTCTTCACAATAAACATGAGTAAAATTTAGACAAGTGATGGTAAAGGTCA

ATATAATTATTTATTTTTAAAATAAATTTTGTATCTAACAGGAAAGCAGTTCTTATGAAA

TTTTTATATTTTCAAAAATTGTTTTGTTCAAATAAAATTTTATGAGTAAAGTTAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAA

>Hs.49215_contig1
BI493248\|N66529\|AA452255\|BI492877\|AW196683\|AI963900\|BF478125\|AI421654\|BE466
675 polyA = 1 polyA = 1
GGGTACCTGGTGGGGCCAATCACCGAGCCATGAACATCAGTAACGTACTCTAAAGACCAA

GGCTACGATGGCTATGATGGTCAGAATTACTACCACCACCAGTGAAGCTCCAGCCTGGGA

TGAATTCATCCATTCTGGCTTTGCATCCGGCTACCATTTTCGAAGTTCAACTCAGGAAGG

TGCAATATAACAAATGTGCATATTATAATGAGGAATGGTACTACCGTTCCAGATTTTCTG

TAATTGCTTCTGCAAAGTAATAGGCTTCTTGTCCCTTTTTTTTCTGGCATGTTATGGAAT

GATCATTGTAAATCAGGACCATTTATCAAGCAGTACACCAACTCATAAGATCAAATTTCA

TTGAATGGTTTGAGGTTGTAGCTCTATAAATAGTAGTTTTTAACATGCCTGTAGTATTGC

TAACTGCAAAAACATACTCTTTGTACAAGAAGTGCTTCTAAGAATTTCATTGACATTAAT

GACACTGTATACAATAAATGTGTAGTTTCTTAATCGCACTACCTATGCAACACTGTGTAT

TAGGTTTATCATCCTCATGTATTTTTATGTGACCTGTATGTATATTCTAATCTACGAGTT

TTATCACAAATAAAAATGCAATCCTTCAAA

>Hs.281587_contig2
R61469\|R15891\|AA007214\|R61471\|AI014624\|N69765\|AW592075\|H09780\|AA709038\|AI33
5898\|AI559229\|F09750\|R49594\|H11055\|T72573\|AA935558\|AA988654\|AA826438\|AI0024
31\|AI299721 polyA = 1 polyA = 2
AAGGTGGGCTTTCATTGTGATTTTTGTTCTGTTGCAGTAATATAGGAGCACATTTTGGCC

ATTGTAATTACAGGGAACAAAGGGATTGCGGACACATATCTGGACTTCTTTTCCTCCCTT

ATTGTTGTGGAAGAGACACTAGAAATGCTCAAACACCTGCAATATACAGAATATACACAA

TTTTATTCCAGTATTTCCCTAACATATGGTTTAAAATTATTCCAGGTATACAGTGTATGC

AATTCTGCATTATCACAGAGGAACAACTTCTTTTTTAAAAAATAAATAGGTCAGCCATTT

TTATTAACGTGCAAAAACTTTATCACTCTAACATGCTCTAGGTAGTTGAGGAAAAGAGGT

CTGATCACTGTTTGTATTTTATTTTCTTTGTGGGAACATTTCACCTGCTGAGTGTACATG

AATTTGCTTTCTATAAAAGGCTTTTATGAGTTTACAGTAGAATCAGTGGAAGGAAGAGTT

AATAAGGGCTGTTTTTAAAAAAACAAACAAACAAACAAAACAAATAATTAAAAAAAAATT

TTACATTCCTTCCTATTCTCTAACTACACTTGGGAAGTGCACTTCAGATAAGTTTGCAGT

GTGACTGAGAGATGAAGGAAATCCATAGAAAAGGTCCTCTTAGTGAACAAAATTTAGTTA

TTAACTTTATAGCTATGAAATTTCCCCGGGCATTTGTTTTTGTTCAAACAGACTTTAACC

TCTGCATCATACTTAACCCTGCGACATGCGTACAGTATGCATATTTTGTTTTGAAAAAAA

ATGTTTCGTTCCAGTCTGTTAAGAATATTCAAAAATAATAAAGGTATTGCTTAATAAAAT

TGCTAGAATTGTTTAGCAGTACATGCACAATATTTTACTAGATTCTTTGTTTTAATAGTG

TTTTGTTGAGACTGAAAATCTTAAAATGGTCTGCGCAAATACAAAAAAAAAGAAAACACC

AAAAAAAAAA

>Hs.79378_mRNA_1 gi\|16306528\|ref\|NM_003914.2\|Homo sapiens eye1in A1
(CCNA1), mRNA polyA = 3
GGTGTTGTTCCGGACACATAGAAAGATAACGACGGGAAGAGCGGGGCCCGCTTTGGGGTC

CAGGCAGGTTTTGGGGCCTCCTGTCTGGTGGGAGGAGGCCGCAGCGCAGCACCCTGCTCG

TCACTTGGGATGGAGACCGGCTTTCCCGCAATCATGTACCCTGGATCTTTTATTGGGGGC

TGGGGAGAAGAGTATCTCAGCTGGGAAGGACCGGGGCTCCCAGATTTCGTCTTCCAGCAG

CAGCCCGTGGAGTCTGAAGCAATGCACTGCAGCAACCCCAAGAGTGGAGTTGTGCTGGCT

ACAGTGGCCCGAGGTCCCGATGCTTGTCAGATACTCACCAGAGCCCCGCTGGGCCAGGAT

CCCCCGCAGAGGACAGTGCTAGGGCTGCTAACTGCAAATGGGCAGTACAGGAGGACCTGT

GGCCAGGGGATCACAAGAATCAGGTGTTATTCTGGATCAGAAAATGCCTTCCCTCCAGCT

GGAAAGAAAGCACTCCCTGACTGTGGGGTCCAAGAGCCCCCCAAGCAAGGGTTTGACATC

TACATGGATGAACTAGAGCAGGGGGACAGAGACAGCTGCTCGGTCAGAGAGGGGATGGCA

TTTGAGGATGTGTATGAAGTAGACACCGGCACACTCAAGTCAGACCTGCACTTCCTGCTG

GATTTCAACACAGTTTCCCCTATGCTGGTAGATTCATCTCTCCTCTCCCAGTCTGAAGAT

ATATCCAGTCTTGGCACAGATGTGATAAATGTGACTGAATATGCTGAAGAAATTTATCAG

TACCTTAGGGAAGCTGAAATAAGGCACAGACCCAAAGCACACTACATGAAGAAGCAGCCA

GACATCACGGAAGGCATGCGCACGATTCTGGTGGACTGGCTGGTGGAGGTTGGGGAAGAA

TATAAACTTCGAGCAGAGACCCTGTATCTGGCTGTCAACTTCCTGGACAGGTTCCTTTCA

TGTATGTCTGTTCTGAGAGGGAAACTGCAGCTCGTAGGAACAGCAGCTATGCTTTTGGCT

TCGAAATATGAAGAGATATATCCTCCTGAAGTAGACGAGTTTGTCTATATCACCGATGAT

ACATACACAAAACGACAACTGTTAAAAATGGAACACTTGCTTCTGAAAGTTCTAGCTTTT

GATCTGACAGTACCAACCACCAACCAGTTTCTCCTTCAGTACTTGAGGCGACAAGGAGTG

TGCGTCAGGACTGAGAACCTGGCTAAGTACGTAGCAGAGCTGAGTCTACTTGAAGCAGAT

CCATTCTTGAAATATCTTCCTTCACTGATAGCTGCAGCAGCTTTTTGCCTGGCAAACTAT

ACTGTGAACAAGCACTTTTGGCCAGAAACCCTTGCTGCATTTACAGGGTATTCATTAAGT

GAAATTGTGCCTTGCCTGAGTGAGCTTCATAAAGCGTACCTTGATATACCCCATCGACCT

CAGCAAGCAATTAGGGAGAAGTACAAGGCTTCAAAGTACCTGTGTGTGTCCCTCATGGAG

CCACCTGCAGTTCTTCTTCTACAATAAGTTTCTGAATGGAAGCACTTCCAGAACTTCACC

TCCATATCAGAAGTGCCAATAATCGTCATAGGCTTCTGCACGTTGGATCAACTAATGTTG

TTTACAATATAGATGACATTTTAAAAATGTAAATGAATTTAGTTTCCCTTAGACTTTAGT

AGTTTGTAATATAGTCCAACATTTTTTAAACAATAAACTGCTTGTCTTATGACAAAAAAA

AAA

>Hs.156469_contig2
AI341378\|AI670817\|AI701687\|AI335022\|AW235883\|AI948598\|AA446356 polyA = 2
polyA = 3
TCCAAGCCATTAAGGACTGTGGAACTTGCTATGATCATGGACGTGCTGTATGGTGGCGTT

TGTTATGCAGGAATTGATACAGATCCTGAGCTAAAATACCCAAAAGGTGCTGGGCGAGTT

GCTTTCTCCAATCAGCAGAGCTATATTGCTGCCATTAGTGCTCGGTTTGTTCAGCTTCAG

CATGGTGATATTGATAAACGTGTGGAGGTAAAGCCATATGTGCTAGATGACCAGATGTGT

GATGAATGCCAGGGCGCACGCTGTGGTGGAAAATTTGCTCCCTTTTTTTGTGCCAATGTC

ACTTGCCTGCAGTATTACTGTGAGTTTTGTTGGGCAAATATCCACTCTCGTGCTGGACGT

GAGTTCCATAAGCCATTGGTAAAGGAAGGTGCTGATCGCCCACGTCAGATCCACTTCCGC

TGGAACTAAGAATAGCAAACTGGCCTCTGTTTAACAAGGAAAGAAAGGGTGCATGTGGCT

TACTGTGTCTGAAGATACTGACATGCAGAAGAAATAAGTGCATTCTTCTGCTTTTCACCC

CAGCTATCAATACATGCATCTTTATCAGCAGCCAAAACACTACAAGCCTCTTGTTTTTCA

CCAAAACCCTACATCTCAGGCTTACTAATTTTTGTGATATTTTCATGTTCAAATAAAATG

TTTTTTTGTATTTTCAAAAAAAAAAAAAAAAAAAAAA

>Hs.6631_mRNA_1 gi\|7020430\|dbj\|AK000380.1\|AK000380 Homo sapiens cDNA
FLJ20373 fis, clone HEP19740 polyA = 3
CTCGATGTAGAGGGGTTGGTAGCAGACAGGTGGTTACATTAGAATAGTCACACAAACTGT

TCAGTGTTGCAGGAACCTTTTCTTGGGGGTGGGGGAGTTTCCCTTTTCTAAAAATGCAAT

GCACTAAAACTATTTTAAGAATGTAGTTAATTCTGCTTATTCATAAAGTGGGCATCTTCT

GTGTTTTAGGTGTAATATCGAAGTCCTGGCTTTTCTCGTTTTCTCACTTGCTCTCTTGTT

CTCTGTTTTTTTAAACCAATTTTACTTTATGAATATATTCATGACATTTGTAATAAATGT

CTTGAGAAAGAATTTGTTTCATGGCTTCATGGTCATCACTCAAGCTCCCGTAAGGATATT

ACCGTCTCAGGAAAGGATCAGGACTCCATGTCACAGTCCTGCCATCTTACTTTCCTCTTG

TCGAGTTCTGAGTGGAAATAACTGCATTATGGCTGCTTTAACCTCAGTCATCAAAAGAAA

CTTGCTGTTTTTTAGGCTTGATCTTTTTCCTTTGTGGTTAATTTTCCTGTATATTGTGAA

AATGGGGGATTTTCCCTCTGCTCCCACCCACCTAAACACAGCAGCCATTTGTACCTGTTT

GCTTCCCATCCCACTTGGCACCCACTCTGACCTCTTGTCAGTTTCCTGTTCCTGGTTCCA

TCTTTTTGAAAAAGGCCCTCCTTTGAGCTACAAACATCTGGTAAGACAAGTACATCCACT

CATGAATGCAGACACAGCAGCTGGTGGTTTTGTGTATACCTGTAAAGACAAGCTGAGAGG

CTTACTTTTTGGGGAAGTAAAAGAAGATGGAAATGGATGTTTCATTTGTATGAGTTTGGA

GCAGTGCTGAAGGCCAAAGCCGCCTACTGGTTTGTAGTTAACCTAGAGAAGGTTGAAAAA

TTAATCCTACCTTTAAAGGGATTTGAGGTAGGCTGGATTCCATCGCCACAGGACTTTAGT

TAGAATTAAATTCCTGCTTGTAATTTATATCCATGTTTAGGCTTTTCATAAGATGAAACA

TGCCACAGTGAACACACTCGTGTACATATCAAGAGAAGAAGGAAAGGCACAGGTGGAGAA

CAGTAAAAGGTGGGCAGATGTCTTTGAAGAAATGCTCAATGTCTGATGCTAAGTGGGAGA

AGGCAGAGAACAAAGGATGTGGCATAATGGTCTTAACATTATCCAAAGACTTGAAGCTCC

ATGTCTGTAAGTCAAATGTTACACAAAAAAAAATGCAAATGGTGTTTCATTGGAATTACC

AAGTGCTTAGAACTTGCTGGCTTTCCCATAGGTGGTAAAGGGGTCTGAGCTCACACCGAG

TTGTGCTTGGCTTGCTTGTGCAGCTCCAGGCACCCGGTGGGCACTCTGGTGGTGTTTGTG

GTGAACTGAATTGAATCCATTGTTGGGCTTAAGTTACTGAAATTGGAACACCCTTTGTCC

TTCTCGGCGGGGGCTTCCTGGTCTGTGCTTTACTTGGCTTTTTTCCTTCCCGTCTTAGCC

TCACCCCCTTGTCAACCAGATTGAGTTGCTATAGCTTGATGCAGGGACCCAGTGAAGTTT

CTCCGTTAAAGATTGGGAGTCGTCGAAATGTTTAGATTCTTTTAGGAAAGGAATTATTTT

CCCCCCTTTTACAGGGTAGTAACTTCTCCACAGAAGTGCCAATATGGCAAAATTACACAA

GAAAACAGTATTGCAATGACACCATTACATAAGGAACATTGAACTGTTAGAGGAGTGCTC

TTCCAAACAAAACAAAAATGTCTCTAGGTTTAGTCAGAGCTTTCACAAGTAATAACCTTT

CTGTATTAAAATCAGAGTAACCCTTTCTGTATTGAGTGCAGTGTTTTTTACTCTTTTCTC

ATGCACATGTTACGTTGGAGAAAATGTTTACAAAAATGGTTTTGTTACACTAATGCGCAC

CACATATTTATGGTATATTTTAAGTGACTTTTTATGGGTTATTTAGGTTTTCGTCTTAGT

TGTAGCACACTTACCCTAATTTTGCCAATTATTAATTTGCTAAATAGTAATACAAATGAC

AACTGCATTAAATTTACTAATTATAAAAGCTGCAAGCAGACTGGTGGCAAGTACACAGCC

CTTTTTTTTGCAGTGCTAACTTGTCTACTGTGTATTATGAAAATTACTGTTGTCCCCCCA

CCCTTTTTTCCTTAAATAAAGTAAAAATGACACCCTAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAA

>Hs.155977_contig1\|AI309080\|AI313045 polyA = 1 WARN polyA = 1
TATACGGCTGCTAGAAGACGACAGAAGGTGGCTTGGGGGTGGATATCTTTGGGTTGCTGG

AAAAGGTGTGGGAAGGTTCAGGATGGTGGGAGGGACTGAGGTCCCTGAGGTGAAGAGGCC

CTTGGTCCTGACGGGTTTGACCCGTGCCTGGACCCTTGGAGCAGTGTTGTGTGAACTTGC

CTAGAACTCTGCCTTCTCCGTTGTCAATAAAGCCTCCCCCTCATGACCTAAAAAAAAAAA

AAAAAAAAAAAAAAAAAGTCGTATCGA

>Hs.95197_mRNA_4 gi\|5817138\|emb\|AL110274.1\|HSM800829 Homo sapiens mRNA;
cDNA DKFZp564I0272 (from clone DKFZp564I0272) polyA = 3
GAGCAGGAAAATATATACCCTAAACAGAAACTCTTACTTGTTTTATGAGCAAGTCTGAGT

GAGTCCTAAAATGGCTGGCGAAGAGCTACCAATACTGACTGACAGGTCACCTTAAAGCCT

CTAGGTGTGCCAAGTTTGATTTATCTTAGGGACTAGAACCTAGTCTTCTAAATGTGATTT

TGCCTTGCTGTTTCGTCCTGATGTGAAGGTAACCACACAGAGAGATTGGGCTGCATCAGT

AATGATATGCATACCTTTCGTGCATCAGTGAGCTTCTTCCCTGTTAACTGTATGACCACA

AAATTTAGCTGGAGTAAATAAATATGCGACAGAAATCCTGGAACAAGATGGTGAAATTGC

TTAAGAATCGAGACTTCAGGGCTCAATGACCTCTGAGCATGTTTCCCAAAGTGTGACCCA

CATGACCATCTGTCTCTCAGTCTCCTGGTCCCTCCGTAGAGCTTCTGAAACTGAATCTTT

GTGGGGTGGGGGTAGCGTTCAAGAATCAAAAGTTGAACCAAGCTCTTTGGGTGATACTTA

TGTATACTGAGGTTCAGGAACTGCTGGAGAGATGACTGGGCACCAAGAGGATGACAGTGA

CTCAGCTGGCATCCCTTAGCTGGTTCATGGCAGAGCTGAGTGGGCACTCCTGTCTCTGAC

CCCAGCTTCAGTGCTCTTTATCTCCTCCATGCCTCCTCAGTCGTGCTGCTCTAAGACTGC

TTACTGGCTTTCCTTCATGTCCTGGGCACAGAGCAGTTCTTTTGGTAGCAGATTTGAGTC

CACTTCCCCCGTGCACAGATCACTGCTCAGGACCCAGAGAGGAGCAGCTCTGCTCCAGCA

GGGTTTTCCATTGCATCACACACCCAAACGGTAGGATCCAACAGTCACACTTGAAAGCAA

CCATAATTGTGAGGTTTCTGATGCTGTAGACTTCCTTACATTTCTCACAACCTAGTTAGA

GAGTCACATGGGGGTGAAGTGTGGCTCGCGACCTGCCCCAACAAGTGCGTGCAGAAGCCA

GGAAACAAAGGAGTAAATTCACTTCAAATGGGATGCACATGGTGTCCGTGATGAAGAGAC

ACATTCAGAATTGCCCAAGGACAGGAAAATGACCAGAGAGAGCCAGAGCTGAGCTGGTAA

TAAAGAGACTCCGAGACTGAGTGGAGTTAATGAGGGAAGCATGCAACGAGTGGGGCAATT

TCAGTTGGTTTCTCTCATTGCTTTAAGCGAAATGAACTATACGGACAGGAGAACAGCCTG

CTTGCCCCAGTCTCTCCTTGGCCGCCCTCTGTTGTCCCTGTCAACTCAGGTGCCCACGGT

GCTCAGAGGAGGTGCTGGCAAAGCCCCTGGAGCCTTATGTAGGCCATGGGGGCTCCTAAA

AGGAACCTGAATGAATCATTTACAGCAGGTCTCTCTTGTAAAGCCCAGCCACAGTAACTC

GTACACTGACTGTTTCAAAAGACAGCCTTTCTTAATCATTTAATTGTTTCATATTCAAAT

ATATCTCCTAATTGTTTTTATTTTTTCCTGATCTAGAAGATATGACAACAGGGTAGAACT

TGGGAAGAGGGAATAGGAAGCTCGCCCTTCCTCCTTCCCTCCTCCCCTCTCTACTTTCCT

TCCTTCCTTGGTCATCAGGTACCTTCTTTGTGCCTGCTGTTGTAGGCTACACCCTATGTT

TGGTGGAAGGCAAAAAGAAAAATCAGTAGGATACAACTCAGTAGGGAAGACAGAGATATT

CAAGCCCCTTGTCCTCCCAGTGTGATAAGTGTGGTGGTTGAGGTGTGAACAAGGGGCTCT

GTGAACAGAGAGGACGAAAGAGGAGCTCCTCCTGAGGCTGTTGGGAAAAGCATCACTGAA

GAGTGACTTTCAGAAGAAGAGAAGAAAAAGAGGAGAACATGCGTGATTTTATAATGAAAT

AGATTAGATAAGGGGAAAAAAGGCATTTAAACAAGGCAAAAAGAACAGGAGAATAGAGAA

GAGATGTGGAGGAGAAGGAGCACTGTAGTAAACACGCAGAAGGACAGGAACACTTAGACA

TGCAACCCACTCCCACCCTCCGTCTTGGGGGAGGAAAGCACACTACTGTCCCAAAGAACT

AATACTGAACCAGTGCTGCCTTGTGGAGAGAGGCATGGCCAAGGCGTTCAGAGACCTGGG

CCTGGTCCCACCGCTGCCCACAGCACTCAGCCTCTGAGCACAGCCTGGGGTCATCTGTGT

GCCCTCTGGCCAAGGCTGATGGTAGTTCTCTGAGTAATTGAGAGTCATTGCCTGTCTGTG

CAGTATTGTGAAAACAAGTCACCTTTTAACTTTAAAACTACTTTAAAAAACTTTAAAGTT

TTAAAAAAACTTCTTTAAAAACTACTCATGAGATGACAGTTTCTCTGACCCTCAGAGGAA

GGCTGGGCTGCGCATACGTGAGGAATTTTTACATGAACATCCCAGGACTTGCTGTTCGCA

GGTGATAAACTGCACCTCCCCAGGACTCCCGCTGCACTCACATGCAGCTCCCTGGACTTC

TGGTATCTGACCCGGCCCATTTCTGTGTTTCAGGGGAGAATTTGGCTTGCGGGAGTACTC

AGAAGTTAAGACGGTGACAGTAAAGATCCCCCAGAAGAACTCCTAAGAAGGCCAAGAAGG

AGGATGAAGCCCAGCCTGCACGTCTGTCCCTCTCTGCTTTCTCTGTAGGGCCCAGCTCTC

AGGAATACAAAGTTGAGCCACGGTCCTTACTTAAAGATTGAAAAGATAACATGTAGGCCA

GGCAGGTCACTGCACAACTAAAGCAAACCAGCTGGGTACAGTTTCTTGGCACTCTGTAAG

GGGCCACCTTAATCATACCAAATATTGGGGAAAGTGGGATAAAGGGAGGAGGAGGAGCTA

GCAGACACATCCAGTATCTCCTTCTGGAGCACAGGATGAAATAAGGGAGCTGTATTATTT

CATGTCTTTGTCACAAAGAACTTTCCTCTCAAGGAAAGGTGACCTTTCTCCTGTCTTCAT

TTTCCTCCTTCCAGGCCCTCCTCGCTCACCCACCCCTCCCTCTCTTCCAAGGAGATGTCA

GCTGAGCTCATTCTGGGGCAGATGTTTGGGCCGGGAACAATTTTTCAAGGTTGTAAAGCC

AAATTATCATTTCATGTTATCCATTTCTTCAAAGCAAAACATGAAATGGTTTTAGCTAGA

GTCAGACCAGAATGAAAATGCCAGGAGCTGGTACACTACAGATGTAGTAAGAACCTGGGA

TATTCCTGACCCAATCTGGTTTTCTTTTACCCATAAATAACATGAATGAAAAAAGATTGG

GACAATAGAGACTGGAAGTCATCATGTGCAGTTCACCGCTTCTGAGCTTGCTGCAGTTTT

GGGGTGTGTGTGTATTAGATTCCTTCTCAGTTATTCTGGAATAAGGCAAGGAGTGGGTTG

TTTTTCATAGCTAGATAAGATCTTTTCCAAAGTTTTTCTTAGAACCAACCAAAAAACAAT

CCGAGTAGGCCCGAGAATTTGATAATGCTGGATGCCTTGCAGACATCATTCAGTTTCTAA

TATTGGGCAACAATTATTATTAAATGAATTATTTCTGTAGTTGGAATCTGTACCTTCTGA

ACCTCTACACCAATAACTGCTGCAGGTGTGATTTTGGTCTGTCACACTGTACATCTATCA

TAATGTGCCCTGTATCTATTGGCAGTGACCTTGGAAAATCTGGCCAAGCCTAGGGGTTTC

CTTTTCCATTTGCCAAGTTCCATTGTGCCAGGACTGCCGTGCTCCACTGAGCTCCTCTGT

CACACCCCATTCTTGCCCCTCACTGGGCAGGCCATGGCCTACAGCTTGCAGGGAGTAAAG

CAGGCCCGCCTCCCTTTCTTCCCATCCACATACTCCTCTTCTGCTTTCCAGTGACTCCAC

CAGTTTGATGTGGGAAGTGTTAGCTTCCTTTCCTTCTTCCATCCCTTCTTCCATCTTTCC

AGCTGTCAAATCCAATCCAGTCTCTAACCTAAATGCAGATCATTTATTTAAAAGTACCAA

ACATAACCCAGAGTATGTGGAATATGGGCAACATATATATAGCCTTCTGTATTTAACGAT

CTTCTGCTTCTTAACCGTACCAGTTTTCTATTTATAACTCTTATCTATCCATGATGTTTT

AAAGTCTCCACTTGCTGTTATTTACAAACGACAGTGCATTCAGCAGCCCAGTGCCGTGAG

CCCTGACAGATGCCGTATTTCTGAGTGCTTCCATGTGAATGCTGCCCTCCTGTAGCATGT

GTCCAAGTGGACATAGCCACTAACCAACTAGTTACCTTTGGACTGCAACAAAAAATGTGA

AAATGAAGATTTATTTCTTTTAATTTACTTAAAAAGAAACCTCTGTGCTAGCAATAAAGC

ATTTATATTGTGCAAAAAAAAAAAAAAAAAAAAAC

>Hs.48956_contig1 N64339\|AI569513\|AI694073 polyA = 1 polyA = 1
TGAAAATTTATATAACTGTTGTTGATAAGGAACATTATCCAGGAATTGATACGTTTATTA

GGAAAAGATATTTTTATAGGCTTGGATGTTTTTAGTTCTGACTTTGAATTTATATAAAGT

ATTTTTATAATGACTGGTCTTCCTTACCTGGAAAAACATGCGATGTTAGTTTTAGAATTA

CACCACAAGTATCTAAATTTGGAACTTACAAAGGGTCTATCTTGTAAATATTGTTTTGCA

TTGTCTGTTGGCAAATTTGTGAACTGTCATGATACGCTTAAGGTGGAAAGTGTTCATTGC

ACAATATATTTTTACTGCTTTCTGAATGTAGACGGAACAGTGTGGAAGCAGAAGGCTTTT

TTAACTCATCCGTTTGCCAATCATTGCAAACAACTGAAATGTGGATGTGATTGCCTCAAT

AAAGCTCGTCCCCATTGCTTAAQCCTTCAAAAA

>Hs.118825_mRNA_10 gi\|1495484\|emb\|X96757.1\|HSSAPKK3 H. sapiens mRNA for MAP
kinase kinase polyA = 3
CTTTTAGCTGCCAGCCCTGGCCCATCATGTAGCTGCAGCACAGCCTTCCCTAACGTTGCA

ACTGGGGGAAAAATCACTTTCCAGTCTGTTTTGCAAGGTGTGCATTTCCATCTTGATTCC

CTGAAAGTCCATCTGCTGCATCGGTCAAGAGAAACTCCACTTGCATGAAGATTGCACGCC

TGCAGCTTGCATCTTTGTTGCAAAACTAGCTACAGAAGAGAAGCAAGGCAAAGTCTTTTG

TGCTCCCCTCCCCCATCAAAGGAAAGGGGAAAATGTCTCAGTCGAAAGGCAAGAAGCGAA

ACCCTGGCCTTAAAATTCCAAAAGAAGCATTTGAACAACCTCAGACCAGTTCCACACCAC

CTAGAGATTTAGACTCCAAGGCTTGCATTTCTATTGGAAATCAGAACTTTGAGGTGAAGG

CAGATGACCTGGAGCCTATAATGGAACTGGGACGAGGTGCGTACGGGGTGGTGGAGAAGA

TGCGGCACGTGCCCAGCGGGCAGATCATGGCAGTGAAGCGGATCCGAGCCACAGTAAATA

GCCAGGAACAGAAACGGCTACTGATGGATTTGGATATTTCCATGAGGACGGTGGACTGTC

CATTCACTGTCACCTTTTATGGCGCACTGTTTCGGGAGGGTGATGTGTGGATCTGCATGG

AGCTCATGGATACATCACTAGATAAATTCTACAAACAAGTTATTGATAAAGGCCAGACAA

TTCCAGAGGACATCTTAGGGAAAATAGCAGTTTCTATTGTAAAAGCATTAGAACATTTAC

ATAGTAAGCTGTCTGTCATTCACAGAGACGTCAAGCCTTCTAATGTACTCATCAATGCTC

TCGGTCAAGTGAAGATGTGCGATTTTGGAATCAGTGGCTACTTGGTGGACTCTGTTGCTA

AAACAATTGATQCAQGTTQCAAACCATACATGGCCCCTGAAAGAATAAACCCAGAGCTCA

ACCAGAAGGGATACAGTGTGAAGTCTGACATTTGGAGTCTGGGCATCACGATGATTGAGT

TGGCCATCCTTCGATTTCCCTATGATTCATGGGGAACTCCATTTCAGCAGCTCAAACAGG

TGGTAGAGGAGCCATCGCCACAACTCCCAGCAGACAAGTTCTCTGCAGAGTTTGTTGACT

TTACCTCACAGTGCTTAAAGAAGAATTCCAAAGAACGGCCTACATACCCAGAGCTAATGC

AACATCCATTTTTCACCCTACATQAATCCAAAGGAACAGATGTGGCATCTTTTGTAAAAC

TGATTCTTGGAGACTAAAAAGCAGTGGACTTAATCGGTTGACCCTACTGTGGATTGGTGG

GTTTCGGGGTGAAGCAAGTTCACTACAGCATCAATAGAAAGTCATCTTTGAGATAATTTA

ACCCTGCCTCTCAGAGGGTTTTCTCTCCCAATTTTCTTTTTACTCCCCCTCTTAAGGGGG

CCTTGGAATCTATAGTATAGAATGAACTGTCTAGATGGATGAATTATGATAAAGGCTTAG

GACTTCAAAAGGTGATTAAATATTTAATGATGTGTCATATGAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.135118_contig3
AI683181\|AI082848\|AW770198\|AI333188\|AI873435\|AW169942\|AI806302\|AW340718\|BF1
96955\|AA909720 polyA = 1 polyA = 2 testis
CAGTCCCACCATGTATTTTGCTTTGTTTCTAAAAAGCTTTTTAAAAACTGTTATTTAATA

CCAAAGGGAGGAATCGTATGGGTTCTTCTGCCCACCGTTGTGACTAAGAATGCACAGGGA

CTTGGTTCTCGTTGCACCTTTTTTTAGTAACATGTTTCATGGGGACCCACTGTACAGCCC

TTCATTCTGCTGTGTCAGTTTGGCCTGGCCTGACACTGGCTGCCCCAGCGGGGACCACGG

AAGCAGAGTGAGAGCCTTCGCTGAGTCAATGCTACCTTCAGCCCCAGACGCATCCCATTT

CCATGTCTTCCATGCTCACTGCTCATGCACTTTTTACACGGTTTCTTCCAAACAGCCCGG

TCTTGATGCAGGAGAGTCTGGAAAAGGAAGAAAATGGTTTCAGTTTCAAAATTCAAAGGA

AAAAGTTGAGGACTTATTTTGTCCTGTCAAGATTGCAAGAACATGTAAAATGTACGGAGC

TTCATAATACGTTATATTGTTCCGAAGCAGCTCGTTGAGAAACATTTGTTTTCAATAACA

TTTTAGCTTAAAAAAAAA

>Hs.171857_mRNA_1 gi\|13161080\|gb\|AF332224.1\|AF332224 Homo sapiens
protein mRNA, partial cds polyA = 3 clone
TCACCTCGTGGCGTAGGGGAGAGGTAACACCGAGAAGAGGCAGCGGCGGTGGCNCAGAGA

CGATTGGTGCCAAACAGGGCAGAACGCAACTCAGCTCTGGGTTTGTGAATAGCACAATGG

AAGAAGCTGGACTTTGTGGGTTAAGAGAGAAAGCAGATATGTTGTGTAACTCTGAATCAC

ATGATATTCTTCAACATCAAGACTCAAATTGCAGTGCCACAAGTAATAAACATTTATTGG

AAGATGAAGAAGGCCGTGACTTTATAACAAAGAACAGGAGTTGGGTGAGCCCAGTGCACT

GCACACAAGAGTCAAGAAGGGAGCTTCCTGAGCAAGAAGTAGCCCCTCCGTCTGGTCAGC

AAGCTTTACAATTGCAACAGGAACAAAGAAAAAGTCTTAGGAAAAGAAGTTTTATTATTG

ATGCAAGCCCTAAACACTCTTTCCGACTCCAGAGGAGAAGCTGGCAGCTCTCTGTAAGAA

ATATGCTGATCTTGGAAATTCACCTCTTCTATAGAAGAGTTTGTTTTGAACTATACGATT

TGAAACAAAATTCTTTTTTTGGAGACTATGGAAACATTCTCAACAGGGAAACCCTACTAG

ACTTTGTAAAGCAAATAATGGAAAAGATACAGAACTTTTTGAAGAATCATGGGAAATTTT

TATAATTAAATAAATGCTAAAATTCTGTTTTGTGAAACATTTATGGGAATTATCACTGAC

AGTTTTTGTACACTTTCAAATAGTGTTAAAGCAGCAACTCCATGTTGTAAATGCACAAAA

CAAATATTTAGTTAATAATCAACTCCAAGAATAAAGCTGTAACAATAATAGTTAAAAAAA

A

>Hs.18910_mRNA_3 gi\|12804464\|gb\|BC001639.1\|BC001639 Homo sapiens
MGC:1944 IMAGE:2959372 polyA = 3
GGCACGAGGGTCAGCAGCCGCCAGACTTCCTGCCGAAGTCCGAGCCCCCTCCCGGGGCTG

GAGGGGGGCAAGCGGGTTCCGAGGTGCAAAGCCTGGTGCCCCGAGCCCTGCGGAGCTCGG

GGCCAGCATGGCCCCCACGCTGCAACAGGCGTACCGGAGGCGCTGGTGGATGGCCTGCAC

GGCTGTGCTGGAGAACCTCTTCTTCTCTGCTGTACTCCTGGGCTGGGGCTCCCTGTTGAT

CATTCTGAAGAACGAGGGCTTCTATTCCAGCACGTGCCCAGCTGAGAGCAGCACCAACAC

CACCCAGGATGAGCAGCGCAGGTGGCCAGGCTGTGACCAGCAGGACGAGATGCTCAACCT

GGGCTTCACCATTGGTTCCTTCGTGCTCAGCGCCACCACCCTGCCACTGGGGATCCTCAT

GGACCGCTTTGGCCCCCGACCCGTGCGGCTGGTTGGCAGTGCCTGCTTCACTGCGTCCTG

CACCCTCATGGCCCTGGCCTCCCGGGACGTGGAAGCTCTGTCTCCGTTGATATTCCTGGC

GCTGTCCCTGAATGGCTTTGGTGGCATCTGCCTAACGTTCACTTCACTCACGCTGCCCAA

CATGTTTGGGAACCTGCGCTCCACGTTAATGGCCCTCATGATTGGCTCTTACGCCTCTTC

TGCCATTACGTTCCCAGGAATCAAGCTGATCTACGATGCCGGTGTGGCCTTCGTGGTCAT

CATGTTCACCTGGTCTGGCCTGGCCTGCCTTATCTTTCTGAACTGCACCCTCAACTGGCC

CATCGAAGCCTTTCCTGCCCCTGAGGAAGTCAATTACACGAAGAAGATCAAGCTGAGTGG

GCTGGCCCTGGACCACAAGGTGACAGGTGACCTCTTCTACACCCATGTGACCACCATGGG

CCAGAGGCTCAGCCAGAAGGCCCCCAGCCTGGAGGACGGTTCGGATGCCTTCATGTCACC

CCAGGATGTTCGGGGCACCTCAGAAAACCTTCCTGAGAGGTCTGTCCCCTTACGCAAGAG

CCTCTGCTCCCCCACTTTCCTGTGGAGCCTCCTCACCATGGGCATGACCCAGCTGCGGAT

CATCTTCTACATGGCTGCTGTGAACAAGATGCTGGAGTACCTTGTGACTGGTGGCCAGGA

GCATGAGACAAATGAACAGCAACAAAAGGTGGCAGAGACAGTTGGGTTCTACTCCTCCGT

CTTCGGGGCCATGCAGCTGTTGTGCCTTCTCACCTGCCCCCTCATTGGCTACATCATGGA

CTGGCGGATCAAGGACTGCGTGGACGCCCCAACTCAGGGCACTGTCCTCGGAGATGCCAG

GGACGGGGTTGCTACCAAATCCATCAGACCACGCTACTGCAAGATCCAAAAGCTCACCAA

TGCCATCAGTGCCTTCACCCTGACCAACCTGCTGCTTGTGGGTTTTGGCATCACCTGTCT

CATCAACAACTTACACCTCCAGTTTGTGACCTTTGTCCTGCACACCATTGTTCGAGGTTT

CTTCCACTCAGCCTGTGGGAGTCTCTATGCTGCAGTGTTCCCATCCAACCACTTTGGGAC

GCTGACAGGCCTGCAGTCCCTCATCAGTGCTGTGTTCGCCTTGCTTCAGCAGCCACTTTT

CATGGCGATGGTGGGACCCCTGAAAGGAGAGCCCTTCTGGGTGAATCTGGGCCTCCTGCT

ATTCTCACTCCTGGGATTCCTGTTGCCTTCCTACCTCTTCTATTACCGTGCCCGGCTCCA

GCAGGAGTACGCCGCCAATGGGATGGGCCCACTGAAGGTGCTTAGCGGCTCTGAGGTGAC

CGCATAGACTTCTCAGACCAAGGGACCTGGATGACAGGCAATCAAGGCCTGAGCAACCAA

AAGGAGTGCCCCATATGGCTTTTCTACCTGTAACATGCACATAGAGCCATGGCCGTAGAT

TTATAAATACCAAGAGAAGTTCTATTTTTGTAAAGACTGCAAAAAGGAGGAAAAAAAACC

TTCAAAAACGCCCCCTAAGTCAACGCTCCATTGACTGAAGACAGTCCCTATCCTAGAGGG

GTTGAGCTTTCTTCCTCCTTGGGTTGGAGGAGACCAGGGTGCCTCTTATCTCCTTCTAGC

GGTCTGCCTCCTGGTACCTCTTGGGGGGATCGGCAAACAGGCTACCCCTGAGGTCCCATG

TGCCATGAGTGTGCACACATGCATGTGTCTGTGTATGTGTGAATGTGAGAGAGACACAGC

CCTCCTTTCAGAAGGAAAGGGGCCTGAGGTGCCAGCTGTGTCCTGGGTTAGGGGTTGGGG

GTCGGCCCCTTCCAGGGCCAGGAGGGCAGGTTCCCTCTCTGGTGCTGCTGCTTGCAAGTC

TTAGAGGAAATAAAAAGGGAAGTGAGAAAAAAAAAAAAAAAAAA

>Hs.194774_mRNA_1 gi\|16306633\|gb\|BC001492.1\|BC001492 Homo sapiens
MGC:1774 IMAGE:3510004 polyA = 3 clone
GGCACGAGGGAGGCGGCGGCTCCAGCCGGCGCGGCGCGAGGCTCGGCGGTGGGATCCGGC

GGGCGGTGCTAGCTCCGCGCTCCCTGCCTCGCTCGCTGCCGGGGGCGGTCGGAAGGCGCG

GCGCGAAGCCCGGGTGGCCCGAGGGCGCGATGGCTGCTCCTGTCCCGTGGGCCTGCTGTG

CTGTGCTTGCCGCCGCCGCCGCAGTTGTCTACGCCCAGAGACACAGTCCACAGGAGGCAC

CCCATGTGCAGTACGAGCGCCTGGGCTCTGACGTGACACTGCCATGTGGGACAGCAAACT

GGGATGCTGCGGTGACGTGGCGGGTAAATGGGACAGACCTGGCCCCTGACCTGCTCAACG

GCTCTCAGCTGGTGCTCCATGGCCTGGAACTGGGCCACAGTGGCCTCTACGCCTGCTTCC

ACCGTGACTCCTGGCACCTGCGCCACCAAGTCCTGCTGCATGTGGGCTTGCCGCCGCGGG

AGCCTGTGCTCAGCTGCCGCTCCAACACTTACCCCAAGGGCTTCTACTGCAGCTGGCATC

TGCCCACCCCCACCTACATTCCCAACACCTTCAATGTGACTGTGCTGCATGGCTCCAAAA

TTATGGTCTGTGAGAAGGACCCAGCCCTCAAGAACCGCTGCCACATTCGCTACATGCACC

TGTTCTCCACCATCAAGTACAAGGTCTCCATAAGTGTCAGCAATGCCCTGGGCCACAATG

CCACAGCTATCACCTTTGACGAGTTCACCATTGTGAAGCCTGATCCTCCAGAAAATGTGG

TAGCCCGGCCAGTGCCCAGCAACCCTCGCCGGCTGGAGGTGACGTGGCAGACCCCCTCGA

CCTGGCCTGACCCTGAGTCTTTTCCTCTCAAGTTCTTTCTGCGCTACCGACCCCTCATCC

TGGACCAGTGGCAGCATGTGGAGCTGTCCGACGGCACAGCACACACCATCACAGATGCCT

ACGCCGGGAAGGAGTACATTATCCAGGTGGCAGCCAAGGACAATGAGATTGGGACATGGA

GTGACTGGAGCGTAGCCGCCCACGCTACGCCCTGGACTGAGGAACCGCGACACCTCACCA

CGGAGGCCCAGGCTGCGGAGACCACGACCAGCACCACCAGCTCCCTGGCACCCCCACCTA

CCACGAAGATCTGTGACCCTGGGGAGCTGGGCAGCGGCGGGGGACCCTCGGCACCCTTCT

TGGTCAGCGTCCCCATCACTCTGGCCCTGGCTGCCGCTGCCGCCACTGCCAGCAGTCTCT

TGATCTGAGCCCGGCACCCCATGAGGACATGCAGAGCACCTGCAGAGGAGCAGGAGGCCG

GAGCTGAGCCTGCAGACCCCGGTTTCTATTTTGCACACGGGCAGGAGGACCTTTTGCATT

CTCTTCAGACACAATTTGTGGAGACCCCGGCGGGCCCGGGCCTGCCGCCCCCCAGCCCTG

CCGCACCAAGCTGGCCCTCCTTCCTCCCTCAGGGGAGGTGGGCCATGCAGCTAACCCACC

CACCAAAGACCCCCTCACCCTGGCCCCTTGGGCTGGACCCTCCAATGCCAGCGACTCCCA

GGAGCCCTTGGGGGACGTGAGGGGAGCCTCTCACATCCGATTTCTCCTCCTGCCCCAGCC

TCCTGTCTATCCCAGGGTCTCTGTTGCCACCATCAGATTATAAGCTCCTGATGCTGGGGG

GGCCCAGCCATCCCCCTCCCCCCAGCACCCACAATTTTCAGTCCCCTCCCCTCTGCCCTG

TTTTGTATACCCCTCCCCTGACCCTGCTCCTATCCCACAGTATTTAATGCCCTGTCAGTC

CCTTCTAGTCTGACTCAATGGTAACTTGCTGTATTTGAATTTTTTATAGATGTATATACA

GGGTGGGGGGAGTGGGCGGTTCTCATTAAACGTCACCATTTCATGAAAAAAAAAAAAAAA

AAA

>Hs.127428_mRNA_2 gi\|16306818\|gb\|BC006537.1\|BC006537 Homo sapiens
MGC:1934 IMAGE:2987903 polyA = 3
GGCACGAGGAGTTTCATAATTTCCGTGGGTCGGGCCGGGCGGGCCAGGCGCTGGGCACGG

TGATGGCCACCACTGGGGCCCTGGGCAACTACTACGTGGACTCGTTCCTGCTGGGCGCCG

ACGCCGCGGATGAGCTGAGCGTTGGCCGCTATGCGCCGGGGACCCTGGGCCAGCCTCCCC

GGCAGGCGGCGACGCTGGCCGAGCACCCCGACTTCAGCCCGTGCAGCTTCCAGTCCAAGG

CGACGGTGTTTGGCGCCTCGTGGAACCCAGTGCACGCGGCGGGCGCCAACGCTGTACCCG

CTGCGGTGTACCACCACCATCACCACCACCCCTACGTGCACCCCCAGGCGCCCGTGGCGG

CGGCGGCGCCGGACGGCAGGTACATGCGCTCCTGGCTGGAGCCCACGCCCGGTGCGCTCT

CCTTCGCGGGCTTGCCCTCCAGCCGGCCTTATGGCATTAAACCTGAACCGCTGTCGGCCA

GAAGGGGTGACTGTCCCACGCTTGACACTCACACTTTGTCCCTGACTGACTATGCTTGTG

GTTCTCCTCCAGTTGATAGAGAAAAACAACCCAGCGAAGGCGCCTTCTCTGAAAACAATG

CTGAGAATGAGAGCGGCGGAGACAAGCCCCCCATCGATCCCAATAACCCAGCAGCCAACT

GGCTTCATGCGCGCTCCACTCGGAAAAAGCGGTGCCCCTATACAAAACACCAGACCCTGG

AACTGGAGAAAGAGTTTCTGTTCAACATGTACCTCACCAGGGACCGCAGGTACGAGGTGG

CTCGACTGCTCAACCTCACCGAGAGGCAGGTCAAGATCTGGTTCCAGAACCGCAGGATGA

AAATGAAGAAAATCAACAAAGACCGAGCAAAAGACGAGTGATGCCATTTGGGCTTATTTA

GAAAAAAGGGTAAGCTAGAGAGAAAAAGAAAGAACTGTCCGTCCCCCTTCCGCCTTCTCC

CTTTTCTCACCCCCACCCTAGCCTCCACCATCCCCGCACAAAGCGGCTCTAAACCTCAGG

CCACATCTTTTCCAAGGCAAACCCTGTTCAGGCTGGCTCGTAGGCCTGCCGCTTTGATGG

AGGAGGTATTGTAAGCTTTCCATTTTCTATAAGAAAAAGGAAAAGTTGAGGGGGGGGCAT

TAGTGCTGATAGCTGTGTGTGTTAGCTTGTATATATATTTTTAAAAATCTACCTGTTCCT

GACTTAAAACAAAAGGAAAGAAACTACCTTTTTATAATGCACAACTGTTGATGGTAGGCT

GTATAGTTTTTAGTCTGTGTAGTTAATTTAATTTGCAGTTTGTGCGGCAGATTGCTCTGC

CAAGATACTTGAACACTGTGTTTTATTGTGGTAATTATGTTTTGTGATTCAAACTTCTGT

GTACTGGGTGATGCACCCATTGTGATTGTGGAAGATAGAATTCAATTTGAACTCAGGTTG

TTTATGAGGGGAAAAAAACAGTTGCATAGAGTATAGCTCTGTAGTGGAATATGTCTTCTG

TATAACTAGGCTGTTAACCTATGATTGTAAAGTAGCTGTAAGAATTTCCCAGTGAAATAA

AAAAAAATTTTAAGTGTTCTCGGGGATGCATAGATTCATCATTTTCTCCACCTTAAAAAT

GCGGGCATTTAAGTCTGTCCATTATCTATATAGTCCTGTCTTGTCTATTGTATATATAAT

CTATATGATTAAAGAAAATATGCATAATCAGACAAGCTTGAATATTGTTTTTGCACCAGA

CGAACAGTGAGGAAATTCGGAGCTATACATATGTGCAGAAGGTTACTACCTAGGGTTTAT

GCTTAATTTTAATCGGAGGAAATGAATGCTGATTGTAACGGAGTTAATTTTATTGATAAT

AAATTATACACTATGAAACCGCCATTGGGCTACTGTAGATTTGTATCCTTGATGAATCTG

GGGTTTCCATCAGACTGAACTTACACTGTATATTTTGCAATAGTTACCTCAAGGCCTACT

GACCAAATTGTTGTGTTGAGATGATATTTAACTTTTTGCCAAATAAAATATATTGATTCT

TTTCTAAAAAAAAAAAAAAAAAAAA

>Hs.126852_contig1
AI802118 BF197404 BF224434\|AA931964\|AW236083\|AI253119\|AW614335\|AI671372\|AI7
93240\|AW006851\|AI953604\|AI640505\|AI633982\|AW195809\|AI493069\|AW058576\|AW2936
22 polyA = 2 polyA = 3
AAACCAGTGTATCCAGTCATGGAAAAGAAGGAGGAAGATGGCACCCTGGAGCGGGGGCAC

TGGAACAACAAGATGGAGTTTGTGCTGTCAGTGGCTGGGGAGATCATTGGCTTAGGCAAC

GTCTGGAGGTTTCCCTATCTCTGCTACAAAAATGGGGGAGGTGAGATGAGAGCCCTTGTG

CCACCCCACCCACTCCTGGAAGGAGGATACTTCCATCTCCTGCACTTACGGCCCCTCTGG

GGAGTCCCATAGATGTATAGAATTCTGGAGGTAGGAGGACGCTTGGAGGTCATTAAGGAC

ACTCTGTAAGAGACTAAGACCTAGAAAGGTTACGTGACTATCCCAGGGCTCTTTCTATTA

TAACGTGGCATCGTAGAAATATGAGCACAAGCTGGAACCAGGTGGATGAGAGTTTGGATT

CTGGCTCTGCTACTTAACACTCTGTGTGATCTTGGACAAGTTACTTAAGCTCTCAGAGCA

TCAATTGCCGCTCCTGCAAATTGAGATAATAATGCCTGCCTTTCAAGGTCATTGTAAGGA

TTAGAGACAATGTGTGTAAAGCACTTAATAAATAGTAGCTCTGCTGATGATGACGTTGAT

AACCAAACTGTTCTGTGGTCTTAAGTAATAAATAGTAGCTCTGCTGATGATGACGTTGAT

AACCAAACTGTTCTGTGGTCTTAAGTAATAAGTAGTAGCTCTGTTGATGATGACGTTGAT

AACCAAACTGTTCTGTGGTCTTAAGTAATAAGTAGTAGCTCTGCTGATGATGACGTTGAT

AACCAAACTGTTCTGTGGTCTTAAGTAATAAATAGTAGCTCTGCTGATGATGATGTTGAT

AACCAAACTGTTCTGTGGTCTTAAGTAATAAATAGTAGCTCTGCTGATGATGACGTTGAT

AACCAAACTGTTCTGTGGTCTTAAGTAATAAATAGTAGCTCTGCTGATGATGACGTTGAT

AACCAAACTGTTCTGTGGTCTTAAGTAATAAATAGTAGCTCTGCTGATGATGACGTTGAT

AAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.28149_mRNA_1 gi\|14714936\|gb\|BC010626.1\|BC010626 Homo sapiens clone
MGC:17687 IMAGE: 3865868 polyA = 3
GGAAGACATCAGGATGTACCATCTGCCCTTCTGTCGGACCCCAGGGTACGTCCCATGAGC

GCGGCCGAGCTGCGTCGAGGGCAGCAGAGCGTGCTGCAGTGCTCAGGGACCCGGACTCTG

CAGTTTCTCCTGCACTGTTTTCACCTTTGGCCAGACGGGCTCTGGGAAGACCTACACCCT

GACTGGACCCCCTCCCCAGGGGGAGGGGGTGCCTGTACCCCCCAGCCTGGCTGGCATCAT

GCAGAGGACCTTCGCCTGGCTGTTGGACCGCGTGCAGCACCTGGGTGCCCCTGTCACCCT

TCGCGCCTCTTATCTGGAGATCTACAATGAGCAGGTTCGGGACTTGCTGAGCCTGGGGTC

TCCCCGGCCCCTCCCTGTTCGCTGGAACAAGACTCGGGGCTTCTATGTGGAGCAGCTGCG

GGTGGTGGAATTTGGGAGTCTGGAGGCCCTGATGGAACTTTTGCAAACGGGTCTCAGCCG

TCGAAGGAACTCAGCCCACACCCTGAACCAGGCCTCCAGCCGAAGCCATGCCCTGCTCAC

CCTTTACATCAGCCGTCAAACTGCCCAGCAGATGCCTTCTGTGGACCCTGGGGAGCCCCC

TGTTGGTGGGAAGCTGTGCTTTGTGGACCTGGCAGGCAGTGAGAAGGTAGCAGCCACGGG

ATCCCGTGGGGAGCTGATGCTTGAGGCTAACAGCATCAACCGAAGCCTGCTGGCCCTGGG

TCACTGCATCTCCCTGCTGCTGGACCCACAGCGGAAGCAGAGCCACATCCCTTTCCGGGA

CAGCAAGCTCACCAAGTTGCTGGCAGACTCACTGGGAGGGCGCGGGGTCACCCTCATGGT

GGCCTGCGTGTCCCCCTCAGCCCAGTGCCTTCCTGAGACTCTCAGCACCCTGCGATATGC

AAGCCGAGCTCAGCGGGTCACCACCCGACCACAGGCCCCCAAGTCTCCTGTGGCAAAGCA

GCCCCAGCGTTTGGAGACAGAGATGCTGCAGCTCCAGGAGGAGAACCGTCGCCTGCAGTT

CCAGCTGGACCAAATGGACTGCAAGGCCTCAGGGCTCAGTGGAGCCCGGGTGGCCTGGGC

CCAGCGGAACCTGTACGGGATGCTACAGGAGTTCATGCTAGAGAATGAGAGGCTCAGGAA

AGAAAAGAGCCAGCTGCAGAATAGCCGAGACCTGGCCCAGAATGAGCAGCGCATCCTGGC

CCAGCAGGTCCATGCACTAGAGAGGCGTCTCCTCTCTGCCTGCTACCATCACCAGCAGGG

TCCTGGCCTGACCCCACCGTGTCCCTGCTTGATGGCCCCAGCTCCCCCTTGCCATGCACT

GCCACCCCTCTACTCCTGCCCCTGCTGCCACATCTGCCCACTGTGTCGAGTGCCCCTGGC

CCACTGGGCCTGCCTGCCAGGGGAGCACCACCTGCCCCAGGTGTTGGACCCTGAGGCCTC

AGGTGGCAGGCCCCCATCTGCCCGGCCCCCACCCTGGGCACCCCCATGCAGCCCTGGCTC

TGCCAAGTGCCCAAGAGAGAGGAGTCACAGTGACTGGACTCAGACCCGAGTCCTGGCAGA

GATGTTGACGGAGGAGGAGGTGGTACCTTCTGCACCTCCCCTGCCTGTGAGGCCCCCGAA

GACATCACCAGGGCTCAGAGGTGGGGCCGGGGTTCCAAACCTGGCCCAGAGACTGGAGGC

CCTCAGAGACCAGATTGGCAGCTCCCTGCGACGTGGCCGCAGCCAGCCACCCTGCAGTGA

GGGCGCACGGAGCCCAGGCCAAGTCCTCCCTCCCCATTGAAGGCCAAGTGGGAACCCAGG

AGACTGCTGTGTGACCTCAGACTGGGCTCCACACTCTTGGGCTTCAGTCTGCCCATCTGC

TGAATGGAGACAGCAGCTGCTACTCCACCTGCAGCTGGGCTAGGGGCGGGGACTGGGGGT

GCTATTTAGGGGAACAAGGGGATTCAGGAGAAACCAGGCAGCAGGGGATGAAATACATGA

ATAAAGAGAGGCATCAGCTCCAAAAAAAAAAAAAAAAAAAAAAA

>Hs.35453_mRNA_3 gi\|7018494\|emb AL157475.1 HSM802461 Homo sapiens mRNA;
cDNA DKFZp761G151 (from clone DKFZp761G151); partial cds polyA = 3
CTCCCCCTGAGAGAGGCTGGGCAGCACCCCCCTTCTGCCAGGAGTGCCAGCCAAGGTGCC

AGACCCCTGTCCAGTGGCAAGCTGGAAGGCTTTCAGAGCATCGATGAAGCTATAGCCTGG

CTCAGGAAGGAACTGACGGAGATGCGGCTGCAGGACCAGCAACTGGCCAGACAGCTCATG

CGCCTGCGTGGCGACATCAACAAGCTGAAAATCGAACACACCTGCCGCCTCCACAGGAGG

ATGCTCAACGATGCCACCTACGAGCTGGAGGAGCGGGATGAGCTGGCCGACCTCTTCTGT

GACTCCCCTCTTGCCTCCTCCTTCAGCCTCTCCACACCACTCAAGCTTATTGGCGTGACC

AAGATGAACATCAACTCTCGGAGGTTCTCTCTCTGCTGAGGAGCCCTCAGACTGGGCGGA

GGGGCTGGAGCGGAGGGCTTGGGCTGGAGGGGTGTCAGAGGAAGCTGAGGCCAAGTTACT

CCAGTGGGTCTCCCGGAGGCAGGGGTCCCTGGGACTGGCGACTCAAGGGCCCCAGGACCT

ATTCAGTGGTGCTCTCCCACCCAGGGGCCCTGGGTGTGGATGCCAGTGTCTCTGTGACTG

GCTCTTGCTTACTACCCAAAGAGCTCTGCAGAAGGGCCGCTCCAACCAAGATGTTAAAGG

AGACCTGGGTTCCCACCATAATCCATCCCTCCACGGTCACGTTCCTGTTTCCTGGAATCA

CTGGTGCTATGAACTGGGATTCCCAAAGGGAGGCCCCCCAACAAAGCTGTCATTTTTGCA

GAAGGCTGTCCCGCAAGGGCCTTGGGGGAAATTAGGCATGTCAGATGTGCCTGTCTCACG

TGCTGTTGCTGTCCTCTAAGTATTGTCTCAAATTCACCCTAAGTACATGACTCAGCAACA

TTGACAGGGAGCTACTAGGAAGGGAAAATCGAAAGGCATGACAAATGGGCACTTGGGGAC

GCAGCCCCAGTGGCTGGCAGCCAGTGTCTCTGGTGAGCCTGACACTACAAGGCTGTGTAA

ATTGTAAATTCTGGCGTGTGCTGGGACATGTGATGGGGGCACTAGCGTAGCTTGGGTGCA

ACAAGCACAGATGTCCCCATTGTCTCCCCTGGCCACATGCATCTCCAAAGAGCCTCTTCA

CTGCCACCCACACCCCAGGGTGACAGCCTGGGAGACCACTGGTGACTGAACCAGGCAGGT

CCTGAAAGCATTTTCCATAACTGAATTCTCCTGCAGGGGCGTGACCGGGGCCTCCTGGTG

GATTCTGGTGGTGTCACCTTACTGCCCTCTCTGGAAAGACAATCTAGGGAGCCCAGAGGC

CCATCCTGAGCCTCCTCTGAGATTTTGTGCCTGACCTAAACAACTAGTTTTAATAAGACT

GTTACTGATGTGTTGTTCACTTGTTAGTAACTGATTTTTGTCCAAATGCGGAAGCCACTT

GTGTAGGTCAACTACAGTGCGTAGGATTTGATTTTAAGAGTTTCTCCCTCCCAACAGGCT

TGAGGATCAGCAAGTTAAGACCCCAGCAGGTTAGGGAGGTCAGTCTGGGGTCATACGGCA

TGGCAGGGGTCCCTCGGCCAGACCCGTAGAATCCTGAGATAAGGAGTGTTTCTGACCTTT

GGTGTCATCTAGTCGAGTCCTCTCATTAGTAAAGGAGCAAAGTGAAACCTGGGGGAGGAG

AAGGACTTCCCTCAGGTTGCACAGCTGTTTAGGCTATAGAATATTGATGTGTGAAACCAT

TATTGATAATGCCTAGTAGATCACATGTCAATGAACTTGAACCCCAAAGATGGTCGTGAT

GCTTTGCCAAACCCGCACACTGCCAACCCCTCTACTCTCCACCTCAGCCCCCACCCACAT

CTCCCAGAGTATTGCAATTCAGAACATTTGGGTCAAGGTGGAGCAAGGCACTGACAGTGG

CCCCACAGGGCATGTGTCACTAATCACTGTCCCATGGTCTACGCACGGCATCTGGCTGCT

CTGTCTACTGTGACTTCTTCCTGTGTAATCTCAGTGGGGCCCGTGTCCACCCACACATCG

TGACCCACATAGGGGAGAGGTTGCTTTTCTTTTGTGGGCTGAGAGTAGGACAATGCAAAT

GAATGATCTCTAGTAGACAGAAAAGAACTTGGTCTCTTTTTTAAAATTTCAAAGAGCCAG

AAGTTCTATGCCTCCTTCAAAGTAGGCAGAACAACGCAGCCAAGATCTACTGTCTGCCAT

GCTCTGTGCAATGAAGTCTGCAGGCCTGAGGACCATGTACTGCTGTCCTTCCTCAGAGCT

CTGCACAAACACTGCCAAGTCCTGAAGACGCATTCCTTTCCTGCCAACCTCTTTCCAGAT

AAGCCCTTGAGGTCTCGGGCTGACCTACACACACACACACACACACACACACACACACAC

ACACCCCCACACACACACACACACGACAGAGAACATGCCATAAACATCCTTGAACCCATG

CAGGAAAGCCCATCCCATATTCTGAAAAAATGCCAAATTAGGTTTTTCTTTCTTTTTGGA

AATCAGTCATTACAGTAACCGAAACCATTGGGTTCAGCGAAAATGGAAAGATTTAGCTGA

ATGTAGTCAGTCCAATTAAGTTGGATGCAACTGAGTGATTTAGTTGCTTGGGTAACCCAG

TGCTTGCTTGCTTTCTTCATTCTCTGGGTGGAAACTAAGATCAAGACACATGTTTGGGGA

TAAGTTAAATGTCTGAGCTATTTTGCTCGGTTTATCCTAAGAGAACTTTATTATGGGATG

AGGAGGTGACCCAAGATGAGAAGTGGAGGGGGACAGCGATGTTTTCTAAACATCGTCCAG

TGTTGACTGGCTTCCTTACTTTGCACAGTGAACACAACTAACCACATTAATTCAGCTTTG

TGAAGTCCCTGCTCTCTGTGGGTTCTATGAGTCAGCAGCAACATTGGCCTAACCTCCGTC

CCAGCCTCCTGGCTCACCACATGTGTACAGTGCTGTTTGCAGTTGTACTCATTATCCATC

CATCTCTCTGCCATCCCCAAGCATCGCTGGGTGTAAAACGCAAACTCTCCACCGACACTG

CCATGCGTGGTCATGTCTTGATGCCTTCAGGGGCTCAGTAGCTATCAAAGAGGCCTGGAG

GGCCTGGGCAGGCTTGACGATGCCTGACCGAGTTCAAGACCCACACCCTGTAGCAATACC

AAGTGCTATTACATAATCAATGGACGATTTATACTTTTATTTTTTATGATTATTTGTTTC

TATATTGCTGTTAGAAAAAGTGAAATAAAAATACTTCAAAAGAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAGAAAAAAAAAAAAAAAAAAA

>Hs.180570_contig1 RO8175\|AA707224\|AA699986\|R11209\|W89099\|T98002\|AA494546
polyA = 2 polyA = 3
TGAAGGACCGCGATCCTAAAGAGATTGAATGGGACGACCTGGCCCAGCTGCCCTTCCTGA

CCATGTGCGTGAAGGAGAGCCTGAGGTTACATCCCCCAGCTCCCTTCATCTCCCGATGCT

GCACCCAGGACATTGTTCTCCCAGATGGCCGAGTCATCCCCAAGGGCATTACCTGCCTCA

TCGATATTATAGGGGTCCATCACAACCCAACTGTGTGGCCGGATCCTGAGTCTACGACCC

CTTCCGCTTTGACCCAGAGAACAGCAAGGGGAGGTCACCTCTGGCTTTTAATTCCCTTCT

CCGCAGGGCCCAGGAACTGCATCGGGCCAGCGTTTCCCATGGCGGAGATGAAAGTGGTTC

CTGGCGTTGATGCTGCTGCACTTCCGGTTCCTGCCAGACCACACTGAGCCCCGCAGGAAG

CTGGAACTGATCATTGCGGCCGAGGGCGGGCTTTGGCTGCGGGTGGAGCCCCTGAATGTA

GGCTTGCAGTGACTTTCTGACCCATCCACCTGTTTTTTTGCAGATTGTCATGAATAAAAC

GGTGCTGTCACCTCAAAAAAAAAAAANNNAAAA

>Hs.196270_mRNA_1 gi\|11545416\|gb\|AF283645.1\|AF283645 Homo sapiens
chromosome 8 map 8q21 polyA = 3
GAGTCCTCTCGTTGGTCCCGGAGGTGGGGTTGCGCTCACAAGGGGCGACCGTCGCCACGG

TGGCGGCCACTGCATCGCGTCCCACCTCCGCGGCCCTGGGCGCCGTGGTGTCGACGGGCC

CCGAGCCTATGACGGGCCAGGGCCAGTCGGCGTCCGGGTCGTCGGCGTGGAGCACGGTAT

TCCGCCACGTCCGGTATGAGAACCTGATAGCGGGCGTGAGCGGCGGCGTCTTATCCAACC

TTGCGCTGCATCCGCTCGACCTCGTGAAGATCCGCTTCGCCGTGAGTGATGGATTGGAAC

TGAGACCGAAATATAATGGAATTTTACATTGCTTGACTACCATTTGGAAACTTGATGGAC

TACGGGGACTTTATCAAGGAGTAACCCCAAATATATGGGGTGCAGGTTTATCCTGGGGAC

TCTACTTTTTCTTTTACAATGCCATCAAGTCATATAAAACAGAAGGAAGAGCTGAACATT

TAGAGGCAACAGAATACCTTGTCTCAGCTGCTGAAGCTGGAGCCATGACCCTCTGCATTA

CAAACCCATTATGGGTAACAAAAACTCGCCTTATGTTACAGTATGATGCTGTTGTTAACT

CCCCACACCGACAATATAAAGGAATGTTTGATACACTTGTGAAAATATATAAGTATGAAG

GTGTGCGTGGATTATATAAGGGATTTGTTCCTGGGCTGTTTGGAACATCGCATGGTGCCC

TTCAGTTTATGGCATATGAATTGCTGAAGTTGAAGTACAACCAGCATATCAATAGATTAC

CAGAAGCCCAGTTGAGCACAGTAGAATATATATCTGTTGCAGCACTATCCAAAATATTTG

CTGTCGCAGCAACATACCCATATCAAGTCGTAAGAGCTCGTCTTCAGGATCAACACATGT

TTTACAGTGGTGTAATAGATGTAATCACAAAGACATGGAGGAAAGAAGGCGTCGGTGGAT

TTTACAAGGGAATTGCTCCTAATTTGATTAGAGTGACTCCAGCCTGCTGTATTACCTTTG

TGGTATATGAAAACGTCTCACATTTTTTACTTGACCTTAGAGAAAAGAGAAAGTAAGCTC

AAAGAGGACAATTCCAGTATATCTGCCCAAGGCAGCAACAAGCTCTTTTGTGTTTAAGGC

ATAAAAGAAGAATTCTGCATAGAAACATGGCTCATATTCGAAATTGCTCTATAGTCATTA

GAAGCCAGAGAACTGCTAAGTCTCCTGCAATGTTTTTCTTGCTTTTTGCCTTCCCCATAT

ATATGGAACTTGGCTACCTCTGCCTGAAATGGCTGCCATCAACACAATGTTAAAACTGAC

ACGAAGGATAGAGTTTCACAGATTTCTACGTTTTATTGGTGGAAGCTGATTTGCAACATT

TGCTAAATGGATTAGATGAATGTACTTCTTTTTGTGAGCTTACTTGCCTGGATTGCTTTA

AAATTAACCTTTGTGCAATACCAAGAAAATAGCTCTTTAAAAGAATGTCTTTGTATGTCT

CAAGGTAAATTAAGGATTTACTGAATAAGGTGTTGACCAAATCCAGACCATTTTATTTTA

TTTTTTTATTTATTTATTTTTTGAGATGGAGTCTTGCTTTGTCGCCCAGGCTGGAGTGCA

GTGGCGTGATCTCAGCTCACTGCAACCTCCACCTCCCGGGTTCACGCCATTCTCCTGCCT

CAGCCTCCTGAGTAGCTGGGACTACAGGCACCTGCCACCACGCCTGGCTAACTTTTTTTT

ATATTTTGAGTAGAAATGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACC

TTGTGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGCGC

CTGGCCAGACCATTTTAGAATTGGGAAATTTTAGTGAGAAAAAATGCACTGTAAATATGC

TTTAGTTTTAATTCAGTTGGGATGCACTACCTAGCGAAAATTGAGAAACTATATACTTCT

CAGAGAAATATCTGACATCTATTGTCATTCCATTGCTATTTTTTTTCCCCAGAGACTTCC

ATAATTTAAAATAAAATCCTAGATCCAGTTCTTGTTTTTTGGCATAAATACTTAATCTAT

TTTAAATTTATAAAATCTGAGCTTCTAGGATCCAGCTGTGTCAACCTTTATTTAGCATAT

ATAACTATAAATCACTTATTACAGATGCTAAATAGATCACCTTTTACAGATGCTGAAATG

TTTGGGATATGTTTGTTGACAAGGTAAATGGAAATGAGAAACTTTATACTTCAGTTTTCA

GATATATGGATCTAGATCCCAAATAAATGATTAATCTTCATTGGTTTCTCAAATTCAGGT

TGAAATACAAATTAATAGCCTTTATTGATTTTACTTTTATGAGTCATTGTAGACATCTAT

AAATATAAAAGGGCCTGTACCCAAAGGATGCCAGAATACTAGTATTTTTATTTATCGTAA

ACATCCACGAGTGCTGTTGCACTACCATCTATTTGTTGTAAATAAAAGTGTTGTTTTCAA

AAAAAAAAAAAAAA

>Hs.9030_mRNA_3 gi\|12652600\|gb\|BC000045.1\|BC000045 Homo sapiens clone
MGC:2032 IMAGE:3504527 polyA = 3
CTAGAGGGGCGGAAAGTAACAAGGAGGTGGGGGTACAAATCCTCAGCTCCTGCTTCCGCA

AGCACTAACCTGCTCTGAAGTGAGCCAGGCAGCTCTGGCCATCTTTTCCCAGCCACAGAA

TCAGGTGATGGTCCAGAATTAAGAGCTGTCACCTGTGTCATTCACTCACAATGGAAGAAA

TGAAGAAGACTGCCATCCGGCTGCCCAAAGGCAAACAGAAGCCTATAAAGACGGAATGGA

ATTCCCGGTGTGTCCTTTTCACCTACTTCCAAGGGGACATCAGCAGCGTAGTGGATGAAC

ACTTCTCCAGAGCTCTGAGCAATATCAAGAGCCCCCAGGAATTGACCCCCTCGAGTCAGA

GTGAAGGTGTGATGCTGAAAAACGATGATAGCATGTCTCCAAATCAGTGGCGTTACTCGT

CTCCATGGACAAAGCCACAACCAGAAGTACCTGTCACAAACCGTGCCGCCAACTGCAACT

TGCATGTGCCTGGTCCCATGGCTGTGAATCAGTTCTCACCGTCCCTGGCTAGGAGGGCCT

CTGTTCGGCCTGGGGAGCTGTGGCATTTCTCCTCCCTGGCGGGCACCAGCTCCTTAGAGC

CTGGCTACTCTCATCCCTTCCCCGCTCGGCACCTGGTTCCAGAGCCCCAGCCTGATGGGA

AACGTGAGCCTCTCCTAAGTCTCCTCCAGCAAGACAGATGCCTAGCCCGTCCTCAGGAAT

CTGCCGCCAGGGAGAATGGCAACCCTGGCCAGATAGCTGGAAGCACAGGGTTGCTCTTCA

ACCTGCCTCCCGGCTCAGTTCACTATAAGAAACTATATGTATCTCGTGGATCTGCCAGTA

CCAGCCTTCCAAATGAAACTCTTTCAGAGTTAGAGACACCTGGGAAATACTCACTTACAC

CACCAAACCACTGGGGCCACCCACATCGATACCTGCAGCATCTTTAGTCAAGTTGGAGGA

GAAAGACAACACTTGGTCTAAGACACGGCAGCAAGACATCCCTGCATATTGTTCCAGATA

AAAATGAAAGCTGCTCACACCCACTTGCCTCCCCAATCTGTTAAACAGCTTCGTGTCTAG

TATGAGCTCAGTACTTGCCCTGTGAAAATCCCAGAAGCCCCCGCTGTCAATGTTCCCCAT

CCACACCCTGCTTGCTCCTGTGTAACAGCTCAGATGATGAATAATAATAAAACTGTACTT

TTTTGGATGGTGAAAAAAAAAAAAAAAAAAAA

>Hs.1282_mRNA_3 gi\|4559405\|ref\|NM_000065.1\|Homo sapiens complement
component 6 (C6), mRNA polyA = 1
TTGCCTTGTGTTAGCTAGCAATAAGAAAAGAAGCTTTGTTTGGATTAACATATATACCCT

CTTCATTCTGCATACCTATTTTTTCCCCAATAATTTGCAGCTTAGGTCCGAGGACACCAC

AAACTCTGCTTAAAGGGCCTGGAGGCTCTCAAGGCATGGCCAGACGCTCTGTCTTGTACT

TCATCCTGCTGAATGCTCTGATCAACAAGGGCCAAGCCTGCTTCTGTGATCACTATGCAT

GGACTCAGTGGACCAGCTGCTCAAAAACTTGCAATTCTGGAACCCAGAGCAGACACAGAC

AAATAGTAGTAGATAAGTACTACCAGGAAAACTTTTGTGAACAGATTTGCAGCAAGCAGG

AGACTAGAGAATGTAACTGGCAAAGATGCCCCATCAACTGCCTCCTGGGAGATTTTGGAC

CATGGTCAGACTGTGACCCTTGTATTGAAAAACAGTCTAAAGTTAGATCTGTCTTGCGTC

CCAGTCAGTTTGGGGGACAGCCATGCACTGAGCCTCTGGTAGCCTTTCAACCATGCATTC

CATCTAAGCTCTGCAAAATTGAAGAGGCTGACTGCAAGAATAAATTTCGCTGTGACAGTG

GCCGCTGCATTGCCAGAAAGTTAGAATGCAATGGAGAAAATGACTGTGGAGACAATTCAG

ATGAAAGGGACTGTGGGAGGACAAAGGCAGTATGCACACGGAAGTATAATCCCATCCCTA

GTGTACAGTTGATGGGCAATGGGTTTCATTTTCTGGCAGGAGAGCCCAGAGGAGAAGTCC

TTGATAACTCTTTCACTGGAGGAATATGTAAAACTGTCAAAAGCAGTAGGACAAGTAATC

CATACCGTGTTCCGGCCAATCTGGAAAATGTCGGCTTTGAGGTACAAACTGCAGAAGATG

ACTTGAAAACAGATTTCTACAAGGATTTAACTTCTCTTGGACACAATGAAAATCAACAAG

GCTCATTCTCAAGTCAGGGGGGGAGCTCTTTCAGTGTACCAATTTTTTATTCCTCAAAGA

GAAGTGAAAATATCAACCATAATTCTGCCTTCAAACAAGCCATTCAAGCCTCTCACAAAA

AGGATTCTAGTTTTATTAGGATCCATAAAGTGATGAAAGTCTTAAACTTCACAACGAAAG

CTAAAGATCTGCACCTTTCTGATGTCTTTTTGAAAGCACTTAACCATCTGCCTCTAGAAT

ACAACTCTGCTTTGTACAGCCGAATATTCGATGACTTTGGGACTCATTACTTCACCTCTG

GCTCCCTGGGAGGCGTGTATGACCTTCTCTATCAGTTTAGCAGTGAGGAACTAAAGAACT

CAGGTTTAACCGAGGAAGAAGCCAAACACTGTGTCAGGATTGAAACAAAGAAACGCGTTT

TATTTGCTAAGAAAACAAAAGTGGAACATAGGTGCACCACCAACAAGCTGTCAGAGAAAC

ATGAAGGTTCATTTATACAGGGAGCAGAGAAATCCATATCCCTGATTCGAGGTGGAAGGA

GTGAATATGGAGCAGCTTTGGCATGGGAGAAAGGGAGCTCTGGTCTGGAGGAGAAGACAT

TTTCTGAGTGGTTAGAATCAGTGAAGGAAAATCCTGCTGTGATTGACTTTGAGCTTGCCC

CCATCGTGGACTTGGTAAGAAACATCCCCTGTGCAGTGACAAAACGGAACAACCTCAGGA

AAGCTTTGCAAGAGTATGCAGCCAAGTTCGATCCTTGCCAGTGTGCTCCATGCCCTAATA

ATGGCCGACCCACCCTCTCAGGGACTGAATGTCTGTGTGTGTGTCAGAGTGGCACCTATG

GTGAGAACTGTGAGAAACAGTCTCCAGATTATAAATCCAATGCAGTAGACGGACAGTGGG

GTTGTTGGTCTTCCTGGAGTACCTGTGATGCTACTTATAAGAGATCGAGAACCCGAGAAT

GCAATAATCCTGCCCCCCAACGAGGAGGGAAACGCTGTGAGGGGGAGAAGCGACAAGAGG

AAGACTGCACATTTTCAATCATGGAAAACAATGGACAACCATGTATCAATGATGATGAAG

AAATGAAAGAGGTCGATCTTCCTGAGATAGAAGCAGATTCCGGGTGTCCTCAGCCAGTTC

CTCCAGAAAATGGATTTATCCGGAATGAAAAGCAACTATACTTGGTTGGAGAAGATGTTG

AAATTTCATGCCTTACTGGCTTTGAAACTGTTGGATACCAGTACTTCAGATGCTTACCAG

ACGGGACCTGGAGACAAGGGGATGTGGAATGCCAACGGACGGAGTGCATCAAGCCAGTTG

TGCAGGAAGTCCTGACAATTACACCATTTCAGAGATTGTATAGAATTGGTGAATCCATTG

AGCTAACTTGCCCCAAAGGCTTTGTTGTTGCTGGGCCATCAAGGTACACATGCCAGGGGA

ATTCCTGGACACCACCCATTTCAAACTCTCTCACCTGTGAAAAAGATACTCTAACAAAAT

TAAAAGGCCATTGTCAGCTGGGACAGAAACAATCAGGATCTGAATGCATTTGTATGTCTC

CAGAAGAAGACTGTAGCCATCATTCAGAAGATCTCTGTGTGTTTGACACAGACTCCAACG

ATTACTTTACTTCACCCGCTTGTAAGTTTTTGGCTGAGAAATGTTTAAATAATCAGCAAC

TCCATTTTCTACATATTGGTTCCTGCCAAGACGGCCGCCAGTTAGAATGGGGTCTTGAAA

GGACAAGACTTTCATCCAACAGCACAAAGAAAGAATCCTGTGGCTATGACACCTGCTATG

ACTGGGAAAAATGTTCAGCCTCCACTTCCAAATGTGTCTGCCTATTGCCCCCACAGTGCT

TCAAGGGTGGAAACCAACTCTACTGTGTCAAAATGGGATCATCAACAAGTGAGAAAACAT

TGAACATCTGTGAAGTGGGAACTATAAGATGTGCAAACAGGAAGATGGAAATACTGCATC

CTGGAAAGTGTTTGGCCTAGCACAATTACTGCTAGGCCCAGCACAATGAACAGATTTACC

ATCCCGAAGAACCAACTCCTACAAATGAGAATTCTTGCACAAACAGCAGACTGGCATGCT

CAAAGTTACTGACAAAAATTATTTTCTGTTAGTTTGAGATCATTATTCTCCCCTGACTCT

CCTGTTTGGGCATGTCTTATTCAGTTCCAGCTCATGACGCCCTGTAGCATACCCCTAGGT

ACCAACTTCCACAGCAGTCTCGTAAATTCTCCTGTTCACATTGTACAAAAATAATGTGAC

TTCTGAGGCCCTTATGTAGCCTGTGACATTAAGCATTCTCACAATTAGAAATAAGAATAA

AACCCATAATTTTCTTCAATGAGTTAATAAACAGAAATCTCCAGAACCTCTGAAACACAT

TCTTGAAGCCCAGCTTTCATATCTTCATTCAACAAATAATTTCTGAGTGTGTATACAGGA

TGTCAAGTACTGACCAAAGTCCTGAGAACTCGGCAGATAATAAAACAGACAAAAGCCTTT

GCCTTCATGAAGCATACATTCATTCAGGGGTAGACACACAAAAAATGAAATAAACAGGTA

AAATATGTAGC

>Hs.268562_mRNA_2 gi\|15341874\|gb\|BC013117.1\|BC013117 Homo sapiens clone
MGC:8711 IMAGE:3882749 polyA = 3
CTCTCCTCGCCCGCTGGGTGCTGAAGTTGGGCGGATGGCAGCAAACCGGCTCCGCTAGAG

GACCGAGCCGCCCAGCCCCGCTCCCCCGGACCCATCGGCGCGCTGCCCACACCTCCAGGC

GACCGGCCAACTGGGTCCTGAAGTAGCTGAAATGCGAAAAAGGCAGCAGTCCCAAAATGA

AGGAACACCTGCCGTGTCTCAAGCTCCTGGAAACCAGAGGCCCAACAACACCTGTTGCTT

TTGTTGGTGCTGTTGTTGCAGCTGCTCCTGCCTCACTGTGAGGAATGAAGAAAGAGGGGA

AAATGCGGGAAGACCCACACACACTACAAAAATGGAGAGTATCCAGGTCCTAGAGGAATG

CCAAAACCCCACTGCAGAGGAAGTCTTGTCCTGGTCTCAAAATTTTGACAAGATGATGAA

GGCCCCAGCAGGAAGAAACCTTTTCAGAGAGTTCCTCCGAACAGAATACAGTGAAGAGAA

CCTACTTTTCTGGCTTGCTTGTGAAGACTTAAAGAAGGAGCAGAACAAAAAAGTAATTGA

AGAAAAGGCTAGGATGATATATGAAGATTACATTTCTATACTATCACCAAAAGAGGTCAG

TCTTGATTCTCGAGTTAGAGAGGTGATCAATAGAAATCTGTTGGATCCCAATCCTCACAT

GTATGAAGATGCCCAACTTCAGATATATACTTTAATGCACAGAGATTCTTTTCCAAGGTT

TTTGAACTCTCAAATTTATAAGTCATTTGTTGAAAGTACTGCTGGCTCTTCTTCTGAATC

TTAATGTTCATTTAAAAACAATCATTTTGGAGGGCTGAGATGGGAAATAAAAGTAGTTAA

ATAACATCAGAAACTGAGTTCCTGGAGAACTACAGTTTAGCATTCCTCAGGCTACTGTGA

AAACACAACCGTTATGGTCTTTGTCTCCATTTTTATCAAGGTTTTCCATGGTTAAGTTTG

GAGAAAATACCACACAAAACAATGAATTGCCAAATTGTTTGTTTTATTCAAGACTCATTC

TACTTGCAAGCAAAGTGTATTTGTAGTCCTATGAACAGTCTCCTCGTGTATCTCCAGAGA

CTGCATGTGCAAAGTAAAATGCTTCATTTGCCACATAGTTGTTGTAATATTTAATCCAGT

AGCATAACTTATATCTGTATTTAAGGACTTTTGTGCAATATGGTCTTAAGAAATAATTGC

CAAAAAAATCGGCCATGGTTCTGCATTTTTAACATAATCTAAGACAGAAAAAAAGCAATT

TTTACTATGTAACAATGGTATTCAACATTCTATATACTGTGTTTAGTACACTAATTTTGA

AGCCAATATTTCTGTACATGAAAAAGAGCTATTTATCTCTGTTTGTTGGAAAATCCTAAT

GGGGATTCCTCTGGTTGTTCACTGCCAAAACTGTGGCATTTTCATTACAGGAGAGTTTAC

TATGCTAAAAGCAAAAAACAAAAAAAAAAAAAAAGGGAAGAAGGAAAAAAGCAAAAAACA

ATTTGAAGATATCCTATCTCAATGACAAATCAAAAGAGTGATATTGCTTTTAACTGTAAT

AGAAGAAAATGAATTTATGTATATATCAGATGTCCAATACTGTAATTAATTTATTAAAGA

CTGGCTCTCCAGTTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.151301_mRNA_3 gi\|16041747\|gb\|BC015754.1\|BC015754 Homo sapiens clone
MGC:23085 IMAGE:4862492 polyA = 3
AAAAGAACCAGGATTGCATTTGAAGTTAAGCTGCAAAAAACCAGTCGATCAACAGATTTT

CGAGTCCCACAGTCAATATGCACCATGTTTAATGTTATGGTTGATGCCAAAGCTCAATCA

ACAAAACTTTGCAGCATGGAAATGGGCCAAGAGTTTGCTAAAATGTGGCATCAATACCAT

TCAAAAATAGACGAACTAATTGAAGAAACTGTTAAAGAAATGATAACACTCTTGGTTGCA

AAGTTCGTTACTATCTTGGAAGGAGTGCTGGCAAAATTATCCAGATATGACGAAGGGACT

TTGTTTTCTTCTTTTCTGTCATTTACCGTGAAGGCAGCTTCCAAATATGTGGATGTACCT

AAACCCGGGATGGACGTGGCCGACGCCTACGTGACTTTCGTCCGCCATTCTCAGGATGTC

CTGCGTGATAAGGTCAATGAGGAGATGTACATAGAAAGGTTATTTGATCAATGGTACAAC

AGCTCCATGAACGTGATCTGCACCTGGTTGACGGACCGGATGGACTTACAGCTTCATATT

TATCAGTTGAAAACACTAATTAGGATGGTAAAGAAAACCTACAGAGATTTCCGATTGCAA

GGGGTCCTGGACTCCACCTTAAACAGCAAGACCTATGAAACGATCCGGAACCGTCTCACT

GTGGAGGAAGCCACAGCATCAGTGAGTGAAGGTGGGGGACTGCAGGGCATCAGCATGAAG

GACAGCGATGAGGAAGACGAAGAAGACGATTAGACCATTTGGTCCTAGAGTCTGCTGGGA

CAGAGTCCTGTAATCAGTGCATGTCCTTAGTCTGTTAGTTAAACCCATTAGGAATTTTCT

GTCAACTACCATGCCCATGAGATGTTTATCAATACAACTGCCATTTTAGCTATGTGGTAC

CAAGATTAGCAAATGACCTTCATATCCACTGATTTCCTGATGTCCATGTCTATATGTTTA

CAAGCAATATGGAGCACCATTCTTTAAATACTGTTCATGGAGAATACATAGTCTAACCAC

TAGGCGTGTCCCTGTTATCAGCAAAGATCAATGATGCTTCATTCATGTACTATGTATGCA

TTGGTGGTAAATGGATGTGAGGGCAAGTACATCAAGTACATTCACTCTGTTTCACGTATG

TGGATGCCAGTTAATTAAATGAGTACGTAAATAAATTAATTAAAACACATAGATCTGCTT

TGTGTTTTTATTTTTATTTTTTGAAAAACAAAAGGCAAGTCTCCAACAATTAACTTTTGA

TGCTTTCTGTTCCCCTAAAACCAAAAAATGAACCCCTTGTGTCGTTGTTAACCCATCCTT

TCATTTACTCATATAATTAGCCAAAAAAAAAAGGATGGCTACATACCAATGGATTGATTC

TCTTAATTGCCACGGCAAGGGGGCGATCCTATCATGACTTAACATCAAGCGCGCAGTTCA

AAACTACTGTCTTCTGTCAAAGTTTTCTCCTCTTAAATGTTATTTTGCTTTTACGTCTCA

ACTGTGTATGTAAAAAAAACGAATATTTAAATTACAACCCTAGACTAAAAATGTGTTTAT

AATAAGATGTGGATATTTCCTTCAGTAGATTGTAACCATAATTTAAATTATTTTGTTCCA

CACTGTTTTTTATATCTGTCATGTACATTGCATTTTGATCTGTAACTGCACAACCCTGGG

GTTTGCTGCAGAGCTATTTCTTTCCATGTAAAGTAGTGGATCCATCTTGCTTTTGCCTTA

TATAAAGCCTACAGTTATGGAAGTGTGGAAAACTGTGGCTTCTCAATAAATATTCAGATG

TCCTAAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAA

>Hs.111_contig1 AA946776\|AW242338\|H24274\|AI078616 polyA = 1 polyA = 2
ACCTGAACTGTCTAAGATATTCTAAGCAAAGTTGACAAAGACAATTCTCCACTTGAGCCC

TTAAAAATGTAACCACTATAAAGGTTTCACGCGGTGGTTCTTATTGATTCGCTGTGTCAT

CACATCAGCTCCACTGTTGCCAAACTTTGTCGCATGCATAATGTATGATGGAGGCTTGGA

TGGGAATATGCTGATTTTGTTCTGCACTTAAAGGCTTCTCCTCCTGGAGGGCTGCCTAGG

GCCACTTGCTTGATTTATCATGAGAGAAGAGGAGAGAGAGAGAGACTGAGCGCTAGGAGT

GTGTGTATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTGTGTAGCGGGAGATGTGG

GCGGAGCGAGAGCAAAAGGACTGCGGCCTGATGCATGCTGGAAAAAGACACGCTTTTCAT

TTCTGATCAGTTGTACTTCATCCTATATCAGCACAGCTGCCATACTTCGACTTATCAGGA

TTCTGGCTGGTGGCCTGCGCGAGGGTGCAGTCTTACTTAAAAGACTTTCAGTTAATTCTC

ACTGGTATCATCGCAGTGAACTTAAAGCAAAGACCTCTTAGTAAAAAATAAAAAAAATAA

A

>Hs.150753_contig1 AI123582\|AI288234 polyA = 0 polyA = 0
GCTTCTCTTTAAAATTGACCCAAGGCATGAGCCACTGCGCCTGGCCAGCAAATGCTTTTT

GTGCAGAATACACTTCTTTCAGGCATTGTCAGGTGCTGTTTTGTTTAAGCTCTAACTCAC

CCCTGGAATACAGGGGAATGATGACAACCAGCCCAGCCAGGCCTGACTCATCATGGTCAC

ATCCAGCCCCCACCCCCGGCCAACTAACCACTGCAGGCTCCTCTTCCAGACTCACCAGGG

GGCCTCGAGGCCCCGGCATCTCCCTTGGCCCTGGGTGTGGGTTTTACAAGACTGTGTCTT

TCATGACATCATAGCCCAACCATGTGAGAAGAAGGAGAAGGCCCCCCTTTCTTCATTAAT

CTGAAAA

>Hs.82109_mRNA_1 gi\|14250611\|gb\|BC008765.1\|BC008765 Homo sapiens clone
MGC:1622 IMAGE:3347793 polyA = 3
GGCACGAGGAAGGGCCTGTGGGTTTATTATAAGGCGGAGCTCGGCGGGAGAGGTGCGGGC

CGAATCCGAGCCGAGCGGAGAGGAATCCGGCAGTAGAGAGCGGACTCCAGCCGGCGGACC

CTGCAGCCCTCGCCTGGGACAGCGGCGCGCTGGGCAGGCGCCCAAGAGAGCATCGAGCAG

CGGAACCCGCGAAGCCGGCCCGCAGCCGCGACCCGCGCAGCCTGCCGCTCTCCCGCCGCC

GGTCCGGGCAGCATGAGGCGCGCGGCGCTCTGGCTCTGGCTGTGCGCGCTGGCGCTGAGC

CTGCAGCCGGCCCTGCCGCAAATTGTGGCTACTAATTTGCCCCCTGAAGATCAAGATGGC

TCTGGGGATGACTCTGACAACTTCTCCGGCTCAGGTGCAGGTGCTTTGCAAGATATCACC

TTGTCACAGCAGACCCCCTCCACTTGGAAGGACACGCAGCTCCTGACGGCTATTCCCACG

TCTCCAGAACCCACCGGCCTGGAGGCTACAGCTGCCTCCACCTCCACCCTGCCGGCTGGA

GAGGGGCCCAAGGAGGGAGAGGCTGTAGTCCTGCCAGAAGTGGAGCCTGGCCTCACCGCC

CGGGAGCAGGAGGCCACCCCCCGACCCAGGGAGACCACACAGCTCCCGACCACTCATCAG

GCCTCAACGACCACAGCCACCACGGCCCAGGAGCCCGCCACCTCCCACCCCCACAGGGAC

ATGCAGCCTGGCCACCATGAGACCTCAACCCCTGCAGGACCCAGCCAAGCTGACCTTCAC

ACTCCCCACACAGAGGATGGAGGTCCTTCTGCCACCGAGAGGGCTGCTGAGGATGGAGCC

TCCAGTCAGCTCCCAGCAGCAGAGGGCTCTGGGGAGCAGGACTTCACCTTTGAAACCTCG

GGGGAGAATACGGCTGTAGTGGCCGTGGAGCCTGACCGCCGGAACCAGTCCCCAGTGGAT

CAGGGGGCCACGGGGGCCTCACAGGGCCTCCTGGACAGGAAAGAGGTGCTGGGAGGGGTC

ATTGCCGTAGGCCTCGTGGGGCTCATCTTTGCTGTGTGCCTGGTGGGTTTCATGCTGTAC

CGCATGAAGAAGAAGGACGAAGGCAGCTACTCCTTGGAGGAGCCGAAACAAGCCAACGGC

GGGGCCTACCAGAAGCCCACCAAACAGGAGGAATTCTATGCCTGACGCGGGAGCCATGCG

CCCCCTCCGCCCTGCCACTCACTAGGCCCCCACTTGCCTCTTCCTTGAAGAACTGCAGGC

CCTGGCCTCCCCTGCCACCAGGCCACCTCCCCAGCATTCCAGCCCCTCTGGTCGCTCCTG

CCCACGGAGTCGTGGGGTGTGCTGGGAGCTCCACTCTGCTTCTCTGACTTCTGCCTGGAG

ACTTAGGGCACCAGGGGTTTCTCGCATAGGACCTTTCCACCACAGCCAGCACCTGGCATC

GCACCATTCTGACTCGGTTTCTCCAAACTGAAGCAGCCTCTCCCCAGGTCCAGCTCTGGA

GGGGAGGGGGATCCGACTGCTTTGGACCTAAATGGCCTCATGTGGCTGGAAGATCCTGCG

GGTGGGGCTTGGGGCTCACACACCTGTAGCACTTACTGGTAGGACCAAGCATCTTGGGGG

GGTGGCCGCTGAGTGGCAGGGGACAGGAGTCCACTTTGTTTCGTGGGGAGGTCTAATCTA

GATATCGACTTGTTTTTGCACATGTTTCCTCTAGTTCTTTGTTCATAGCCCAGTAGACCT

TGTTACTTCTGAGGTAAGTTAAGTAAGTTGATTCGGTATCCCCCCATCTTGCTTCCCTAA

TCTATGGTCGGGAGACAGCATCAGGGTTAAGAAGACTTTTTTTTTTTTTTTTTTTAAACT

AGGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTTT

GTCGCTCATGTGTGCAACAGGGTATGGACTATCTGTCTGGTGGCCCCGTTTCTGGTGGTC

TGTTGGCAGGCTGGCCAGTCCAGGCTGCCGTGGGGCCGCCGCCTCTTTCAAGCAGTCGTG

CCTGTGTCCATGCGCTCAGGGCCATGCTGAGGCCTGGGCCGCTGCCACGTTGGAGAAGCC

CGTGTGAGAAGTGAATGCTGGGACTCAGCCTTCAGACAGAGAGGACTGTAGGGAGGGCGG

CAGGGGCCTGGAGATCCTCCTGCAGACCACGCCCGTCCTGCCTGTGGCGCCGTCTCCAGG

GGCTGCTTCCTCCTGGAAATTGACGAGGGGTGTCTTGGGCAGAGCTGGCTCTGAGCGCCT

CCATCCAAGGCCAGGTTCTCCGTTAGCTCCTGTGGCCCCACCCTGGGCCCTGGGCTGGAA

TCAGGAATATTTTCCAAAGAGTGATAGTCTTTTGCTTTTGGCAAAACTCTACTTAATCCA

ATGGGTTTTTCCCTGTACAGTAGATTTTCCAAATGTAATAAACTTTAATATAAAGTAAAA

AAAAAAAAAAAAAAAAAAAAAAAA

>Hs.44276_mRNA_2 gi\|12654896\|gb\|BC001293.1\|BC001293 Homo sapiens clone
MGC:5259 IMAGE:3458115 polyA = 3
CGGATGGGGAAAAAAAAAGATGTCAGCTCCTCCGCTGTAGTATTGCTCCTTAAAAACCCC

TCTCTCTGAAAATGACATGCCCTCGCAATGTAACTCCGAACTCGTACGCGGAGCCCTTGG

CTGCGCCCGGCGGAGGAGAGCGCTATAGCCGGAGCGCAGGCATGTATATGCAGTCTGGGA

GTGACTTCAATTGCGGGGTGATGAGGGGCTGCGGGCTCGCGCCCTCGCTCTCCAAGAGGG

ACGAGGGCAGCAGCCCCAGCCTCGCCCTCAACACCTATCCGTCCTACCTCTCGCAGCTGG

ACTCCTGGGGCGACCCCAAAGCCGCCTATCGCCTGGAACAACCTGTTGGCAGGCCGCTGT

CCTCCTGCTCCTACCCACCTAGTGTCAAGGAGGAGAATGTCTGCTGCATGTACAGCGCAG

AGAAGCGGGCGAAAAGTGGCCCCGAGGCAGCTCTCTACTCCCACCCCTTGCCGGAGTCCT

GCCTTGGGGAGCACGAGGTACCCGTGCCCAGCTACTACCGCGCCAGCCCGAGCTACTCCG

CGCTGGACAAGACGCCCCACTGTTCTGGGGCCAACGACTTCGAAGCCCCTTTCGAGCAGC

GGGCCAGTCTCAACCCGCGCGCCGAACATCTGGAATCGCCTCAGCTGGGGGGCAAAGTGA

GTTTCCCTGAGACCCCCAAGTCCGACAGCCAGACCCCCAGCCCCAATGAAATCAAGACGG

AGCAGAGCCTGGCGGGCCCTAAAGGGAGCCCCTCGGAGAGCGAAAAGGAGAGGGCCAAAG

CTGCCGACTCCAGCCCAGACACCTCGGATAACGAAGCGAAAGAGGAGATAAAGGCAGAAA

ACACCACAGGAAATTGGCTGACAGCAAAGAGCGGAAGGAAGAAGAGGTGCCCCTATACTA

AACACCAGACGCTGGAATTGGAGAAAGAATTTCTGTTCAATATGTATTTGACGCGAGAGC

GCCGCCTGGAGATTAGCAAGACCATTAACCTTACAGACAGACAAGTCAAAATCTGGTTTC

AAAATCGCAGAATGAAACTCAAGAAAATGAACCGAGAGAATCGGATCCGGGAACTGACCT

CCAATTTTAATTTCACCTGAGAGCGCGGCCTCTCCTCCTCCCTTCCCGCTCCTTCCTCTC

CCCGCCCCTCCTCCCTTTGTGCCTGGTGATATATTTTTTTTTCCTCCCTGAGTATAAATG

CAATGCGACTGCAAAAAAGGCAAAGACCTCAGACTCTCCTTCCAAGGGACCTGTGGTTCG

TGCTGCGAAGATGCTTCCACTTAAAGCATGAGAAATGGGGTGCCGGGATGTGGGGTGTGG

TGTGTGCCCTCATAGATGGGGGTGGGAGTGTGGCTGGTGTGTGTGTCAAACCCTCACTCA

CCCACGCACTCACACACAGCATTCTGTTCTCCATGCAAAGTTAAGATCGAATCCATCCGC

TTGTAGGGGAAAAAAAGGAAAAAAATTAACCAGAGAGGGTCTGTAATCTCGCAGAGCACA

GGCAGAATCGTTCCTTCCTTGCTGCATTTCCTCCTTAGACTAATAGACGTTTTGGAAAGT

TCGGCTAGTGTTCGTGTGTTTGTCGTAGCACCCAGAGCCTCCACCAAACCCTCTCCATGT

CTTTACCTCCCAGTCGCTCTAAGAATCTGCTTGAAGTCTCGTATTTGTACTGCTTTCTGC

TTTTCTCCCACCCCTCCTAGCACCCCCACATCCCCCATCTAGTAACATCTCAGAAATTTC

ATCCAGAGGAACAAAAAAATTAAAAATAGAACATAGCAAAGCAAAGACAGAATGCCCCCC

CCCAAATATTGTCCTGTCCCTGTCTGGGAGTTGTGTTATTTAAAGATATTCTGTATGTTG

TATCTTTTGCATGTAGCTTCCTTAATGGAGAAAAAAAAATCCTAATAAATTTCCAGAATC

ATAATCCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAA

>Hs.2142_mRNA_4 gi\|13325274\|gb\|BC004453.1\|BC004453 Homo sapiens clone
MGC:4303 IMAGE:2819400 polyA = 3
GCAGTGGCCACGAGAGGCAGGCTGGCTGGGACATGAGGTTGGCAGAGGGCAGGCAAGCTG

GCCCTTGGTGGGCCTCGTCCTGAGCACTCGGAGGCACTCCTATGCTTGGAAAGCTCGCTA

TGCTGCTGTGGGTCCAGCAGGCGCTGCTCGCCTtGCTCCTCCCCACACTCCTGGCACAGG

GAGAAGCCAGGAGGAGCCGAAACACCACCAGGCCCGCTCTGCTGAGGCTGTCGGATTACC

TTTTGACCAACTACAGGAAGGGTGTGCGCCCCGTGAGGGACTGGAGGAAGCCAACCACCG

TATCCATTGACGTCATTGTCTATGCCATCCTCAACGTGGATGAGAAGAATCAGGTGCTGA

CCACCTACATCTGGTACCGGCAGTACTGGACTGATGAGTTTCTCCAGTGGAACCCTGAGG

ACTTTGACAACATCACCAAGTTGTCCATCCCCACGGACAGCATCTGGGTCCCGGACATTC

TCATCAATGAGTTCGTGGATGTGGGGAAGTCTCCAAATATCCCGTACGTGTATATTCGGC

ATCAAGGCGAAGTTCAGAACTACAAGCCCCTTCAGGTGGTGACTGCCTGTAGCCTCGACA

TCTACAACTTCCCCTTCGATGTCCAGAACTGCTCGCTGACCTTCACCAGTTGGCTGCACA

CCATCCAGGACATCAACATCTCTTTGTGGCGCTTGCCAGAAAAGGTGAAATCCGACAGGA

GTGTCTTCATGAACCAGGGAGAGTGGGAGTTGCTGGGGGTGCTGCCCTACTTTCGGGAGT

TCAGCATGGAAAGCAGTAACTACTATGCAGAAATGAAGTTCTATGTGGTCATCCGCCGGC

GGCCCCTCTTCTATGTGGTCAGCCTGCTACTGCCCAGCATCTTCCTCATGGTCATGGACA

TCGTGGGCTTCTACCTGCCCCCCAACAGTGGCGAGAGGGTCTCTTTCAAGATTACACTCC

TCCTGGGCTACTCGGTCTTCCTGATCATCGTTTCTGACACGCTGCCGGCCACTGCCATCG

GCACTCCTCTCATTGGTGTCTACTTTGTGGTGTGCATGGCTCTGCTGGTGATAAGTTTGG

CCGAGACCATCTTCATTGTGCGGCTGGTGCACAAGCAAGACCTGCAGCAGCCCGTGCCTG

CTTGGCTGCGTCACCTGGTTCTGGAGAGAATCGCCTGGCTACTTTGCCTGAGGGAGCAGT

CAACTTCCCAGAGGCCCCCAGCCACCTCCCAAGCCACCAAGACTGATGACTGCTCAGCCA

TGGGAAACCACTGCAGCCACATGGGAGGACCCCAGGACTTCGAGAAGAGCCCGAGGGACA

GATGTAGCCCTCCCCCACCACCTCGGGAGGCCTCGCTGGCGGTGTGTGGGCTGCTGCAGG

AGCTGTCCTCCATCCGGCAATTCCTGGAAAAGCGGGATGAGATCCGAGAGGTGGCCCGAG

ACTGGCTGCGCGTGGGCTCCGTGCTGGACAAGCTGCTATTCCACATTTACCTGCTGGCGG

TGCTGGCCTACAGCATCACCCTGGTTATGCTCTGGTCCATCTGGCAGTACGCTTGAGTGG

GTACAGCCCAGTGGAGGAGGGGGTACAGTCCTGGTTAGGTGGGGACAGAGGATTTCTGCT

TAGGCCCCTCAGGACCCAGGGAATGCCAGGGACATTTTCAAGACACAGACAAAGTCCCGT

GCCCTGTTTCCAATGCCAATTCATCTCAGCAATCACAAGCCAAGGTCTGAACCCTTCCAC

CAAAAACTGGGTGTTCAAGGCCCTTACACCCTTGTCCCACCCCCAGCAGCTCACCATGGC

TTTAAAACATGCTCTCTTAGATCAGGAGAAACTCGGGCACTCCCTAAGTCCACTCTAGTT

GTGGACTTTTCCCCATTGACCCTCACCTGAATAAGGGACTTTGGAATTCTGCTTCTCTTT

CACAACTTTGCTTTTAGGTTGAAGGCAAAACCAACTCTCTACTACACAGGCCTGATAACT

CTGTACGAGGCTTCTCTAACCCCTAGTGTCTTTTTTTTCTTCACCTCACTTGTGGCAGCT

TCCCTGAACACTCATCCCCCATCAGATGATGGGAGTGGGAAGAATAAAATGCAGTGAAAC

CCTAAAAAAAAAAAAAAAAAAAAAA

>Hs.180908_contig1\|AA846824\|AW611680\|AA846182\|AA846342 AA846360 polyA = 2
polyA = 3
TCTTCGCTCCTCTACCCCATAAAATTCCCTACAAATGCAAAAATTCGAGATAGAAGAAGC

CGTCCCTGAAATTGCTGTCTAACATTCACCGGAAACCTCTCCATAAACAAGGAGAAACGA

ATGCACACGCATTTTTGCTAAGAAGCCCGGGATTAAGATTTAAGGATACAAGCTGAAAGA

AAAAATGAAAAATGCTTCTCCGCGCGTCAATCGAGGGGTGGATGCGCCACGCAGCTGAGC

CCAGCTCACAGCCACGCGTAAGACCAAAAGCTGCCATGGGTTCTGCGCGCGGAGACCTCA

GAGCCGAAGAGAGAAGTCCCCGCGTCAGAAACGCTGCGGATGCCAGGTCTTGAAAATGCT

GACTTCTGAGGCTAAGAATTATTTCAAAGACAAAAAGAAAAGACTGGTGAGGAGGCCTTC

CGGTGCAAGGGCGCCTATCCGCTAATTTTGGATGGGGAAGTAGGGATTATTCGTTTAAAT

TCAATCGCGAGCACCAAGTCGGACTGGCCGGGGATGGAGAAGGGCAACCCCCACCTTTAG

AAAAATAAAAGATCTCGAAGGCCAAAAAAAAAAA

>Hs.89436_mRNA_1 gi\|16507959\|ref\|NM_004063.2\|Homo sapiens cadherin 17,
cadherin (liver-intestine) (CDH17), mRNA polyA = 1
AGGGAGTGTTCCCGGGGGAGATACTCCAGTCGTAGCAAGAGTCTCGACCACTGAATGGAA

GAAAAGGACTTTTAACCACCATTTTGTGACTTACAGAAAGGAATTTGAATAAAGAAAACT

ATGATACTTCAGGCCCATCTTCACTCCCTGTGTCTTCTTATGCTTTATTTGGCAACTGGA

TATGGCCAAGAGGGGAAGTTTAGTGGACCCCTGAAACCCATGACATTTTCTATTTATGAA

GGCCAAGAACCGAGTCAAATTATATTCCAGTTTAAGGCCAATCCTCCTGCTGTGACTTTT

GAACTAACTGGGGAGACAGACAACATATTTGTGATAGAACGGGAGGGACTTCTGTATTAC

AACAGAGCCTTGGACAGGGAAACAAGATCTACTCACAATCTCCAGGTTGCAGCCCTGGAC

GCTAATGGAATTATAGTGGAGGGTCCAGTCCCTATCACCATAGAAGTGAAGGACATCAAC

GACAATCGACCCACGTTTCTCCAGTCAAAGTACGAAGGCTCAGTAAGGCAGAACTCTCGC

CCAGGAAAGCCCTTCTTGTATGTCAATGCCACAGACCTGGATGATCCGGCCACTCCCAAT

GGCCAGCTTTATTACCAGATTGTCATCCAGCTTCCCATGATCAACAATGTCATGTACTTT

CAGATCAACAACAAAACGGGAGCCATCTCTCTTACCCGAGAGGGATCTCAGGAATTGAAT

CCTGCTAAGAATCCTTCCTATAATCTGGTGATCTCAGTGAAGGACATGGGAGGCCAGAGT

GAGAATTCCTTCAGTGATACCACATCTGTGGATATCATAGTGACAGAGAATATTTGGAAA

GCACCAAAACCTGTGGAGATGGTGGAAAACTCAACTGATCCTCACCCCATCAAAATCACT

CAGGTGCGGTGGAATGATCCCGGTGCACAATATTCCTTAGTTGACAAAGAGAAGCTGCCA

AGATTCCCATTTTCAATTGACCAGGAAGGAGATATTTACGTGACTCAGCCCTTGGACCGA

GAAGAAAAGGATGCATATGTTTTTTATGCAGTTGCAAAGGATGAGTACGGAAAACCACTT

TCATATCCGCTGGAAATTCATGTAAAAGTTAAAGATATTAATGATAATCCACCTACATGT

CCGTCACCAGTAACCGTATTTGAGGTCCAGGAGAATGAACGACTGGGTAACAGTATCGGG

ACCCTTACTGCACATGACAGGGATGAAGAAAATACTGCCAACAGTTTTCTAAACTACAGG

ATTGTGGAGCAAACTCCCAAACTTCCCATGGATGGACTCTTCCTAATCCAAACCTATGCT

GGAATGTTACAGTTAGCTAAACAGTCCTTGAAGAAGCAAGATACTCCTCAGTACAACTTA

ACGATAGAGGTGTCTGACAAAGATTTCAAGACCCTTTGTTTTGTGCAAATCAACGTTATT

GATATCAATGATCAGATCCCCATCTTTGAAAAATCAGATTATGGAAACCTGACTCTTGCT

GAAGACACAAACATTGGGTCCACCATCTTAACCATCCAGGCCACTGATGCTGATGAGCCA

TTTACTGGGAGTTCTAAAATTCTGTATCATATCATAAAGGGAGACAGTGAGGGACGCCTG

GGGGTTGACACAGATCCCCATACCAACACCGGATATGTCATAATTAAAAAGCCTCTTGAT

TTTGAAACAGCAGCTGTTTCCAACATTGTGTTCAAAGCAGAAAATCCTGAGCCTCTAGTG

TTTGGTGTGAAGTACAATGCAAGTTCTTTTGCCAAGTTCACGCTTATTGTGACAGATGTG

AATGAAGCACCTCAATTTTCCCAACACGTATTCCAAGCGAAAGTCAGTGAGGATGTAGCT

ATAGGCACTAAAGTGGGCAATGTGACTGCCAAGGATCCAGAAGGTCTGGACATAAGCTAT

TCACTGAGGGGAGACACAAGAGGTTGGCTTAAAATTGACCACGTGACTGGTGAGATCTTT

AGTGTGGCTCCATTGGACAGAGAAGCCGGAAGTCCATATCGGGTACAAGTGGTGGCCACA

GAAGTAGGGGGGTCTTCCTTGAGCTCTGTGTCAGAGTTCCACCTGATCCTTATGGATGTG

AATGACAACCCTCCCAGGCTAGCCAAGGACTACACGGGCTTGTTCTTCTGCCATCCCCTC

AGTGCACCTGGAAGTCTCATTTTCGAGGCTACTGATGATGATCAGCACTTATTTCGGGGT

CCCCATTTTACATTTTCCCTCGGCAGTGGAAGCTTACAAAACGACTGGGAAGTTTCCAAA

ATCAATGGTACTCATGCCCGACTGTCTACCAGGCACACAGAGTTTGAGGAGAGGGAGTAT

GTCGTCTTGATCCGCATCAATGATGGGGGTCGGCCACCCTTGGAAGGCATTGTTTCTTTA

CCAGTTACATTCTGCAGTTGTGTGGAAGGAAGTTGTTTCCGGCCAGCAGGTCACCAGACT

GGGATACCCACTGTGGGCATGGCAGTTGGTATACTGCTGACCACCCTTCTGGTGATTGGT

ATAATTTTAGCAGTTGTGTTTATCCGCATAAAGAAGGATAAAGGCAAAGATAATGTTGAA

AGTGCTCAAGCATCTGAAGTCAAACCTCTGAGAAGCTGAATTTGAAAAGGAATGTTTGAA

TTTATATAGCAAGTGCTATTTCAGCAACAACCATCTCATCCTATTACTTTTCATCTAACG

TGCATTATAATTTTTTAAACAGATATTCCCTCTTGTCCTTTAATATTTGCTAAATATTTC

TTTTTTGAGGTGGAGTCTTGCTCTGTCGCCCAGGCTGGAGTACAGTGGTGTGATCCCAGC

TCACTGCAACCTCCGCCTCCTGGGTTCACATGATTCTCCTGCCTCAGCTTCCTAAGTAGC

TGGGTTTACAGGCACCCACCACCATGCCCAGCTAATTTTTGTATTTTTAATAGAGACGGG

GTTTCGCCATTTGGCCAGGCTGGTCTTGAACTCCTGACGTCAAGTGATCTGCCTGCCTTG

GTCTCCCAATACAGGCATGAACCACTGCACCCACCTACTTAGATATTTCATGTGCTATAG

ACATTAGAGAGATTTTTCATTTTTCCATGACATTTTTCCTCTCTGCAAATGGCTTAGCTA

CTTGTGTTTTTCCCTTTTGGGGCAAGACAGACTCATTAAATATTCTGTACATTTTTTCTT

TATCAAGGAGATATATCAGTGTTGTCTCATAGAACTGCCTGGATTCCATTTATGTTTTTT

CTGATTCCATCCTGTGTCCCCTTCATCCTTGACTCCTTTGGTATTTCACTGAATTTCAAA

CATTTGTCAGAGAAGAAAAACGTGAGGACTCAGGAAAAATAAATAAATAAAAGAACAGCC

TTTTCCCTTAGTATTAACAGAAATGTTTCTGTGTCATTAACCATCTTTAATCAATGTGAC

ATGTTGCTCTTTGGCTGAAATTCTTCAACTTGGAAATGACACAGACCCACAGAAGGTGTT

CAAACACAACCTACTCTGCAAACCTTGGTAAAGGAACCAGTCAGCTGGCCAGATTTCCTC

ACTACCTGCCATGCATACATGCTGCGCATGTTTTCTTCATTCGTATGTTAGTAAAGTTTT

GGTTATTATATATTTAACATGTGGAAGAAAACAAGACATGAAAAGAGTGGTGACAAATCA

AGAATAAACACTGGTTGTAGTCAGTTTTGTTTGTTAA

>Hs.151544_mRNA_8 gi\|3153107\|emb\|AL023657.1\|HSDSHP Homo sapiens SH2D1A
cDNA, formerly known as DSHP polyA = 3
AAATCCTTCTTCCAATGTTCCTCCCCTCTCTGTATGAACCCTGTGTTGGGGGGCAGAAGA

TGGAAGCCCTTGGCAAGCTCGATCGAACCAAGCTACTAAATTGCTGAGCTCGTTTTAACT

GAAGTGTGAGAAGGAGGTTTAAGGCAAGTAGACAACATCCTGTTGTTGGGGTGCTTCTCT

CTTTTTTGCACATCTGGCTGAACTGGGAGTCAGGTGGTTGACTTGTGCCTGGCTGCAGTA

GCAGCGGCATCTCCCTTGCACAGTTCTCCTCCTCGGCCTGCCCAAGAGTCCACCAGGCCA

TGGACGCAGTGGCTGTGTATCATGGCAAAATCAGCAGGGAAACCGGCGAGAAGCTCCTGC

TTGCCACTGGGCTGGATGGCAGCTATTTGCTGAGGGACAGCGAGAGCGTGCCAGGCGTGT

ACTGCCTATGTGTGCTGTATCACGGTTACATTTATACATACCGAGTGTCCCAGACAGAAA

CAGGTTCTTGGAGTGCTGAGACAGCACCTGGGGTACATAAAAGATATTTCCGGAAAATAA

AAAATCTCATTTCAGCATTTCAGAAGCCAGATCAAGGCATTGTAATACCTCTGCAGTATC

CAGTTGAGAAGAAGTCCTCAGCTAGAAGTACACAAGGTACTACAGGGATAAGAGAAGATC

CTGATGTCTGCCTGAAAGCCCCATGAAGAAAAATAAAACACCTTGTACTTTATTTTCTAT

AATTTAAATATATGCTAAGTCTTATATATTGTAGATAATACAGTTCGGTGAGCTACAAAT

GCATTTCTAAAGCCATTGTAGTCCTGTAATGGAAGCATCTAGCATGTCGTCAAAGCTGAA

ATGGACTTTTGTACATAGTGAGGAGCTTTGAAACGAGGATTGGGAAAAAGTAATTCCGTA

GGTTATTTTCAGTTATTATATTTACAAATGGGAAACAAAAGGATAATGAATACTTTATAA

AGGATTAATGTCAATTCTTGCCAAATATAAATAAAAATAATCCTCAGTTTTTGTGAAAAG

CTCCATTTTTAGTGAAATATTATTTTATAGCTACTAATTTTAAAATGTCTTGCTTGATTG

TATGGTGGGAAGTTGGCTGGTGTCCCTTGTCTTTGCCAAGTTCTCCACTAGCTATGGTGT

CATAGGCTCTTTTGGGATTTTTGAAGCTGTATACTGTGTGCTAAAACAAGCACTAAACAA

AGAGTGAAGGATTTATGTTTAATTCTGAAAGCAACCTTCTTGCCTAGTGTTCTGATATTG

GACAGTAAAATCCACAGACCAACCTGGAGTTGAAAATCTTATAATTTAAAATATGCTCTA

AACATGTTTATCGTATTTGATGCTACAGGATTTGAAATTGTATTACAAATCCAATGAAAT

GAGTTTTTCTTTTCATTTACCTCTGCCCCAGTTGTTTCTACTACATGGAAGACCTCATTT

TGAAGGGAAATTTCAGCAGCTGCAGCTCATGAGTAACTGATTTGTAACAAGCCTCCTTTT

AAAGTAACCCTACAAAACCACTGGAAAGTTTATGGTTGTATTATTTTTTAAAAAAATTCC

AAGTGATTGAAACCTACACGAGATACAGAATTTTATGCGGCATTTTCTTCTCACATTTAT

ATTTTTGTGATTTTGTGATTGATTATATGTCACTTTGCTACAGGGCTCACAGAATTCATT

CACTCAACAAACATAATAGGGCGCTGAGGGCATAGAAGTAAAAACACCTGGTCCCTGCTC

TCAGTTCACTGTCTTGTTGGACGAGAAAAGAAACAATAACGATAAAAGACAGTGAAAGAA

AATAACGATAAAAGACAGTGAAAGAAAATAACAATAAAAGACAAGGAAAAAATAACAATG

AAAGTTGATAAGTACATGATAAGCGAGGTTCCCCGTGTGTAGGTAGATCTGGTCTTTAGA

GGCAGATAGATAGGTCAGTGCAAATACTCTGGTCCATGGGCCATATGAAAAGGCTAAGCT

TCACTGTAAAATAATAACTGGGAATTCTGGATTGTGTATGGGTGTTGGTGAACTTGGTTT

TAATTAGTGAACTGCTGAGAGACAGAGCTATTCTCCATGTACTGGCAAGACCTGATTTCT

GAGCATTTAATATGGATGCCGTGGGAGTACAAAAGTGGAGTGTGGCCTGAGTAATGCATT

ATGGGTGGTTTACCATTTCTTGAGGTAAAAGCATCACATGAACTTGTAAAGGAATTTAAA

AATCCTACTTTCATAATAAGTTGCATAGGTTTAATAATTTTTAATTATATGGCTTGAGTT

TAAATTGTAATAGGCGTAACTAATTTTAACTCTATAATGTGTTCATTCTGGAATAATCCT

AAACATATGAATTATGTTTGCATGTTCACTTCCAAGAGCCTTTTTTTGAAAAAAAGCTTT

TTTTGAATCATCAAGTCTTTCACATTTAAATAAAGTGTTTGAAAGCTTTATTTAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAGAAAAAAA

>Hs.1657_contig4
AW473119\|AA164586\|AI540656\|AI758480\|AI810941\|AI978964\|AI675862\|AI784397\|AW5
91562\|AW514102\|AI888116\|AI983175\|AI634735\|AI669577\|AI202659\|AI910598\|AI9613
52\|AI565481\|AI886254\|AI538838\|AA291749\|AW571455\|AI370308\|AI274727\|AW473925\|
AW514787\|AI273871\|AW470552\|AI524356\|AI888281\|AW089672\|AI952766\|AW440601\|AT6
54044\|AW438839\|AI972926 polyA = 2 polyA = 3
AATTGTTTTCTAAGTAATTGCTGCCTCTATTATGGCACTTCATTTTTGCACTGTCTTTTG

AGATTCAAGAAAAATTTCTATTCTTTTTTTTGCATCCAATTGTGCCTGAACTTTTAAAAT

ATGTAAATGCTGCCATGTTCCAAACCCATCGTCAGTGTGTGTGTTTAGAGCTGTGCACCC

TAGAAACAACATATTGTCCCATGAGCAGGTGCCTGAGACACAGACCCCTTTGCATTCACA

GAGAGGTCATTGGTTATAGAGACTTGAATTAATAAGTGACATTATGCCAGTTTCTGTTCT

CTCACAGGTGATAAACAATGCTTTTTGTGCACTACATACTCTTCAGTGTAGAGCTCTTGT

TTTATGGGAAAAGGCTCAAATGCCAAATTGTGTTTGATGGATTAATATGCCCTTTTGCCG

ATGCATACTATTACTGATGTGACTCGGTTTTGTCGCAGCTTTGCTTTGTTTAATGAAACA

CACTTGTAAACCTCTTTTGCACTTTGAAAAAGAATCCAGCGGGATGCTCGAGCACCTGTA

AACAATTTTCTCAACCTATTTGATGTTCAAATAAAGAATTAAACTAAAAAAAAAAAAAAA

A

>Hs.35984_mRNA_1 gi\|6049161\|gb\|AF133587.1\|AF133587 Homo sapiens chromosome
22 map 22q11.2 polyA = 3
GGCGCCGCGGACGCTGCTGGAGTCGCCTGGCAACGATGTCGCCTGGCAACTGAATAGGTT

GGCCAGTGGCGCGGGCTACTGGAAGCAGAAAGGGCTGCGGAGGCAGTGAGTGGTTTCTGC

AGAGCTTCATTTGGAAAGGCCTCTGTAGTTGGGGAAAGATGGCCCATTCCCAGAACTCCT

TGGAGCTTCCCATTAACATCAATGCCACCCAGATTACCACTGCCTATGGCCATCGGGCCC

TGCCCAAGCTGAAGGAGGAGCTGCAGTCAGAGGACCTCCAGACGAGGCAGAAAGCCCTCA

TGGCCCTGTGTGACCTCATGCATGACCCCGAGTGTATCTACAAGGCCATGAACATAGGCT

GTATGGAGAACCTGAAAGCTTTGCTGAAGGATAGCAACAGTATGGTGCGCATAAAGACCA

CCGAGGTGCTCCACATCACGGCAAGCCATAGCGTGGGCAGATACGCCTTTCTAGAGCACG

ACATCGTCCTTGCCCTGTCCTTCCTGCTGAATGACCCCAGCCCAGTCTGCCGGGGGAACC

TGTACAAGGCATACATGCAGCTGGTCCAGGTGCCTAGAGGGGCCCAAGAGATCATCAGCA

AAGGTCTGATTTCCTCACTGGTATGGAAGCTGCAGGTGGAGGTGGAGGAGGAGGAGTTCC

AGGAGTTCATCCTGGACACACTGGTCCTCTGCCTGCAGGAGGATGCCACCGAGGCCCTGG

GCAGCAATGTGGTGCTTGTCCTGAAGCAGAAGCTCCTCAGCGCCAACCAGAACATCCGCA

GCAAGGCCGCCCGTGCGCTCCTTAATGTCAGCATATCTCGAGAGGGCAAGAAACAGGTGT

GTCATTTTGACGTCATCCCCATCCTGGTCCATCTGCTGAAAGACCCAGTGGAGCATGTGA

AGTCTAACGCTGCCGGTGCCCTGATGTTCGCCACAGTGATCACTGAAGGGAAGTATGCGG

CCCTGGAGGCACAAGCCATCGGCCTGCTCCTGGAGCTGCTGCACTCCCCCATGACCATAG

CGCGCCTGAATGCCACCAAGGCCCTTACCATGCTGGCAGAGGCCCCCGAGGGCCGCAAGG

CCCTGCAGACGCACGTGCCCACTTTCCGTGCCATGGAGGTGGAGACTTACGAAAAGCCTC

AAGTGGCCGAAGCCTTACAGCGGGCAGCCCGGATCGCCATCAGTGTCATCGAGTTCAAAC

CCTGAGCCCTTCATTCACCTCTGTGAGTGAATAAATGTGCTAAGTCTCTTTAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAA

>Hs.334534_mRNA_2 gi\|17389403\|gb\|BC017742.1\|BC017742 Homo sapiens, clone
IMAGE:4391536, mRNA polyA = 3
AGAGCAGTAAGCTTGTGATAAAGGCCAATTCCAGGTAGCTCTTGAAGGTGATAGCCATCT

ACTTTCCAGTGGCTGCCAACCACAGGGAGTGCCAGTTAACACTGGAAGGATTAAGGCAAG

GTCCCTTCTCTTGAGACTCCCCTCTGAGATCTGAAAAATGAAGTGGCTTAGGAACATCAG

CAGTGAAGAACTGCCAAGAGTTGGTGAAGGTTGTCTCTTCCGAGGGCCTTCTGAAGACAG

GGCTCTTGAACAGACAAGTGGAAGGGCTGTACCAGGGATAAAGGAAAGAAGTGCCTGTCC

AGCAGGGAGCTTGAATTTAAGTTCCATGTATGAAGTCATTGGCTCTATCTGCATTTTTCT

GTCATTCTCTTCATTTGTTTTAAGGTGGAAAATTTTCTTACAGTTGATGCAAAGTATCAA

CTACTTTACCCTACCTTCTCCCCTTTTAGATGGGTTCTTCCTGAGTTTTGGAGTCTTGTA

TGATTATCAGTATTCCCCTGTCAAAATCAAATCTATTCAGGTTTCTTCACTGTTGAGAAC

ACCTAAATGTTTTTATTTTTGAGAAGTGGGGACAGAGTCTCACTATGTCACCCAGGCTGG

AGTGCAATGGCATGATCTCAGCTCACTGCAACCTTCGCCTCCTGGGTTCAAGCGATTCTC

CTGCCTCCGCCTCCTGAGTAGCTGGGATTATAGGCACGCACCACCACGCCCAGCTAATTT

TTTGTATTTTTAGTAGAGACAGAGTTTCACCATGTTGGCCAGGCTGGTCTTGAACTCCTG

ACCTTGTGATCCACCCACCTCGGCCTCCCAGAGTGCTGGGATTACAGGCATGAGCCACCA

CGCTTGGCTAAGAACACCTAAATTTTTATGTTTCTTGGCTCAAAAACCAGTTCCATTTCT

AATGTTGTCCTCACAAGAAGGCTAATTGGTGGTGAGACAGCAGGGGAGGAGGAAGAGCTG

TGGTTTGTAACTTGTTCAACTCAGGCAATAAGCGATTTTAGCTTTATTTAAAGTCTTCTG

TCCAGCTTTAAGCACTTTGTAAGACATGGCTGAAAGTAGCTTTTCTATCAGAATTGCAGA

TAGTCATGTTGGGCTAACAGTCAATTGGATATATTCCTTTACCTCACATGACCCCAGCAA

CTGTGGTGGTATCTAGAGGTGAAACAGGCAAGTGAAATGGACACCTCTGCTGTGAATGTT

TTAGAGAAGGAAATTCAAAAAATGTTGTAACTGAAAGCACTGTTGAATATGGGTATCGGC

TTTCTTTTTCACTTTGACTCTTAACATTATCAGTCAACTTCCACATTAATGAAAGTTGAC

CATAGTTATTTCCAAATAAAAAGAAACCAACTCTTACCAGGTCTTGGACTGTGATGTCAT

ATTATTCAGTTTTATGCTTGTTCCTGAGCAGAACTCATAAGAGTGACATAGTCAGCTGCT

GACGGCACCTCAGCCACGCCACTCTTACTCAGTTCAGTGGGTGTGCTTGCGTGGTAGGAT

GTGGTGCAGCCCTCTCTACGCTCTTCTATTTTTGGTATATTTCCTATCTAACCTTCAAAT

AGCTTCCAATTCTTTTTTTCTTGGACTGGCTTCATTCTGAATTTGTGCTAAAATAATCTT

TCATAAAGAGACCTCAGTTTATAGCGTAACAGACTACACAATGCACTGATGTTTTCATAA

TGTTTAAGGGACCCACTGCAAGAAGCTTGCTGCCTCCTTTTAATTGTATTCATTTAGATT

TTGATTTTCCATGTTAAGAAGGTGAGGTCCATGTTGGTGCCCTTCAGAGTAGAGAACCAT

GTAAACATTAGGAATGAACAGAGGCCTTAGGAATGAATAGAGAGTTTGCCTTATACAATT

TCCTGTTACAAAGCTCTCCCTCTCATGCAAAGTAGGGAACACCTTTTGAGCATCTTTGAA

TTTGACAAATGGTGCTGTTGCAAACACTTTTTTTTTGAGATGAAGTCTCGCGGTTGTCAC

CCGGGCTGGAGTGCAGTGGCGTGATCTCGGCTCACTGCAACTTCCACCTCCTGGGTTCCA

GCAGTTCTCCTGCCTCAGCCTCCCAAGTAGCTGAGATTACAGGCGCCTGCCACCCCACCT

GGCTGATTTTTGTAATTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGATTAAC

TCCTGACCTCAGGTGATCCACCTTTCTCGGCCTCCCAAAGTGCTGGGATTACGGGTGTGA

GCCACCGTGCCCGGCCTGCAAACACATTTTAATTGACAACACTAGGGCTGTTGTACAAAA

TAGTAATGATAGCCATGGAAGTTTTACCTTATTCTGTGAGAAGTGTTCTTAAACTTATTA

AGTGTCTAAACTAAGGTTTAGTGCTTTTTTAAAGGAAAGTTGTCCCAGGATTCATCCTAA

AGAAAGCAAAAGTTAATTCAACTGATCCACCAATGGAATTAGATGGGTAGAGTTGGGTTC

TTGAGTTTTACCACCACTTAGTTCCCACTGAATTTTGTAACTTCCTGTGTTTGCATCCTC

TGTTCCTATTCTGCCCTTGCTCTGTGTCATCTCAGTCATTTGACTTAGAAAGTGCCCTTC

AAAAGGACCCTGTTCACTGCTGCACTTTTCAATGAATTAAAATTTATTTCTGTTCTAAAA

AAAAAAAAAAA

>Hs.60162_mRNA_1 gi\|10437644\|dbj\|AK025181.1\|AK025181 Homo sapiens cDNA
FLJ21528 fis, clone COL05977 polyA = 3
TGATCAACAACTGTCAGCTCCCAGTCAGAGAGAAAGGGCCTCTTCAGTCTGTCTCAGGAG

ACTGGGAGAAACAGCATAAAGGACCCCACAAGGAAGGGAGAGGTACCCTGGGTCAGGCGC

TTGTGGAGAGAGGGCTTCGCATGTAAAGTGACGTCAGGGAAAATAGAACAGAAAAAAAGC

CAGGGCCAGCCCAGAGGCACCTGAGAAGAATCAGACCCACAGCTCAGCCCAGCCCTGGCA

CAGAGAAGAGACAGGCCTGGCAGCACCCAGGGACCCCCTTTCCTCAGCCTCCACCTGCAG

GACAGCAGGAGCACTGATGCGCTGAAGGTACGTTCTGGAGTCTGGAAGCAGCAGAACTGA

AGGAAGTAAACACGGGTGTCTGGGAAGACCCCTCAAGCTGCAGTAAAGCCCAGGACTGAA

TTGGCCACCTGAGGCCAAGGGTGGCACTCCAACCTCCTCCTAAAGGCTGGCTAGAGCCAC

AGGAAAGGGCCAGAAGCCAGAGAAAGGGCAAAGGTGGACCCCTGCCTCCAAACCTCCTCT

GGAGACTGACCTCCTCTTTCCTGTGCCTTATTGTTTCTCCCTCTTCTCTTTGTTCGCCAC

TGGGCGGTGACCTCAGGGATCCTGGCCTAACCTGGTGATTGTGCAGGCAACTGTGTCCGA

GAAGACCCTTCTCTGGAAGATTGAACCCCAATTCAGCCATGGTGACTCCTTTGATGTCAA

ACTGGTAAGGGCTGAGCCGTGGGCACAGGATACCACTCCTTCCAGCTCTTCTGCTGTGAC

CTGCCCATGGAAGTCCCTGTGGACACGAAATCCTGTTTGGATCATCTAACTGGAGGCTCT

CTGTTCTTCACCTCCACGCGCCCTCTTGACCCCAGGAGGTTCAGGGGAGGAAGTACGCCA

CTCTCCACTGGCACCCTCCTTGGCCTACACAGAGTCACCCCTGAGCCCCTCAATGTGTGC

TGAGGTGGGCCCTGCTCTCTGCAGGGGTATGGAGAGAAATAGCTTGGGGTGCTGTGAGGC

CCCGAAGAAGCTGGGCCTGTCCTTCTCCATCGAGGCGATCCTAAAGAGGCCTGCCAGGAG

GAGTGATATGGACAGACCAGAAGGGCCAGGTGAAGAGGGCCCCGGAGAAGCTGCGGCCTC

AGGCTCTGGGCTAGAAAAGCCTCCAAAGGACCAGCCCCAGGAAGGAAGGAAGAGCAAGCG

GAGGGTTCGTACCACCTTCACCACTGAGCAGCTGCATGAGCTGGAGAAGATCTTCCACTT

TACCCACTACCCAGACGTTCACATCCGCAGCCAGCTGGCAGCCAGGATCAACCTCCCAGA

AGCTCGGGTGCAGATCTGGTTCCAGAATCAGCGAGCCAAGTGGCGGAAGCAGGAGAAGAT

TGGCAACCTGGGGGCTCCACAGCAGCTGAGTGAAGCCAGTGTGGTCCTGCCCACAAATCT

GGATGTGGCTGGGCCCACGTGGACATCCACTGCTCTGCGCAGGCTGGCTCCTCCCACGAG

CTGTTGTCCATCGGCTCAAGATCAGCTGGCCTCTGCCTGGTTCCCTGCCTGGATCACCCT

CCTCCCAGCGCACCCATGGGAAACACAGCCTGTCCCAGGTCTTCCCATCCATCAAACTTG

CATCCCTGTGCTATGCATCCTTCCACCTCCACACCCCAAATGGGGCAGCATCTGTGCTAC

TTCAACATAGAGATTGGACATGCTCTCCCCAAATGAGCCACTTTCCTCTCCAGGTGAAGG

CAGGTAGCAGATGTGCCCTGGGCCTCTGGGGAAATCGATCTCACAATCCAAAAATGGCCC

ACAGCCCAGGAAGCTACCCTGAACATGCCAGTTGGAAGGCTGCACCAGACTCAAAAGCAA

ACTAAACAATAAAGGACAGCTCTCTTCTCTCCTGGCTAAAGCTGCTCTCCTGGTTCAGAA

GACAGGCTGGATGAGATCTCAGGCCGAGCTCTGAAATAGGGAGGTAATCCTCCAGCACCT

GTGTTTCCTCTAACTTGCTGTGTGACCTCCAGCCGGTCACTCACCCTCTCTGGACCTCAT

CTGTAAGAGGAGCCAGCTGGATAAGATGATTTCTGAAGACGCTTCCATGGTGGGCACTGA

GGCACAGAGGAGGCCAAGGAGAGGTTGTTTGTTCATGCATGCATTCATCCGTGACACATG

AGTACCTACTGAGGACTCCATAAACAGAACGGGATACAGAGATAAACAATTTGGGTTCTG

TCCACGTTTGTCAAAAGGTGGTGCTGGCCCACCTCTGAAAGCAGAACACTTGCTCAACAA

CCTTGCTGTTGGCCCAAGTCTAACACATTCTTTATGACTGTGAGCATCTCAGAGTGAGAG

AAAAATGTAGAAAGTTTTTTAAATTCTAAACAGGATTTAGTGTCTTTAGTTATCTTGCTG

GATGGGAAAGGGATGTTGTCATTTCTGGCACAAATGAAAAGTAGGACGGAAAGCTCCTTT

CATTCAGTTTATCTTTCCAGGATATATGAAAAGGGACCAGCTGGAAGACTAGCCTCACTC

TGTCCTCGAAAGCCTGAGCTTTCATTCAACTCCCTATTTCCATGCAAAGACGCTGGGCAA

ACCACATGTTCTGTCTGAGCCTCAGTTTTCCTATCCATAAAATGAAGGTAGCCAGGCCTG

CCTCAAAGAGCATTCAGGAGGCTCTGAGAGGACATGAGAGTATTTTGCAAAGTGAGGGCA

AGGCCCAGTGTGGAGTGATATTGTTATTCCAAGATTCCACTGCAAAAGTGGCTGCTTTGG

ATGCCAGCCCAGGATGAGTAGTTCCTGTTCTCAGGGAGGTCATCCGCTGAGCATCCCTTC

TGCACAGATGTCTCTGATTCTTGTCCTTGCAGGTGGAGGACAGGGCCTGCTCCCCTAAGC

TGGGAAGCCTGGAATGACCTCTTGCACAAGCCTAAATTCCAGGAATCTTCCCCAAATCCC

AGATCCTCTGCAATCTACCTGCACCCCTGACCCACCCAGGAGTTGGACCGGGAGTTGGGA

AGCCTAGGTCTTAGTCCTACACTCCTTCTAATTTGCTGTGTAACCTTACCATTAATCTCT

CTGGGTCTCAGTTTTCTCATCTGTATTGGAGGTAGCAGTGCTAGCTCTGCCTTCAGGCAT

GCAATATGCCAGAACTACAGACAACAGCCCACAGGATGCAAAAGTGCTTTGCCATCTTAA

AAATGCCAGATCACTCAGAGCCTATGAATGTGGATATCAACACCAGGTCTCTAGCACCGC

TGGATGAAAGGAGAAGGCTAGAGGCTGAGGGAGGAAAGAGCAGTTAACAAACAAAGGCAG

TAGCTCATCACTTGGGTAGCAGGTACCCATTTTAGGACCCTACACTCAAATGTGCAAAAT

AAAATTTCTATCATTTTGCTATAAAAAAAAAAAAAAAAAAAAA

>NM_004967
GAGTGAGTGAGAGGGCAGAGGAAATACTCAATCTGTGCCACTCACTGCCTTGAGCCTGCT

TCCTCACTCCAGGACTGCCAGAGGCTCACTCCCTTGAGCCTGCTTCCTCACTCCAGGACT

GCCAGAGGAAGCAATCACCAAAATGAAGACTGCTTTAATTTTGCTCAGCATTTTGGGAAT

GGCCTGTGCTTTCTCAATGAAAAATTTGCATCGAAGAGTCAAAATAGAGGATTCTGAAGA

AAATGGGGTCTTTAAGTACAGGCCACGATATTATCTTTACAAGCATGCCTACTTTTATCC

TCATTTAAAACGATTTCCAGTTCAGGGCAGTAGTGACTCATCCGAAGAAAATGGAGATGA

CAGTTCAGAAGAGGAGGAGGAAGAAGAGGAGACTTCAAATGAAGGAGAAAACAATGAAGA

ATCGAATGAAGATGAAGACTCTGAGGCTGAGAATACCACACTTTCTGCTACAACACTGGG

CTATGGAGAGGACGCCACGCCTGGCACAGGGTATACAGGGTTAGCTGCAATCCAGCTTCC

CAAGAAGGCTGGGGATATAACAAACAAAGCTACAAAAGAGAAGGAAAGTGATGAAGAAGA

AGAGGAGGAAGAGGAAGGAAATGAAAACGAAGAAAGCGAAGCAGAAGTGGATGAAAACGA

ACAAGGCATAAACGGCACCAGTACCAACAGCACAGAGGCAGAAAACGGCAACGGCAGCAG

CGGAGGAGACAATGGAGAAGAAGGGGAAGAAGAAAGTGTCACTGGAGCCAATGCAGAAGG

CACCACAGAGACCGGAGGGCAGGGCAAGGGCACCTCGAAGACAACAACCTCTCCAAATGG

TGGGTTTGAACCTACAACCCCACCACAAGTCTATAGAACCACTTCCCCACCTTTTGGGAA

AACCACCACCGTTGAATACGAGGGGGAGTACGAATACACGGGCGTCAATGAATACGACAA

TGGATATGAAATCTATGAAAGTGAGAACGGGGAACCTCGTGGGGACAATTACCGAGCCTA

TGAAGATGAGTACAGCTACTTTAAAGGACAAGGCTACGATGGCTATGATGGTCAGAATTA

CTACCACCACCAGTGAAGCTCCAGCCTG

>NM_002847
GCCTCCCGCCGCCTCCCGCGCGGCCATGGACTGAGCGCCGCCGGCCAGGCCGCGGGGATG

GGGCCGCCGCTCCCGCTGCTGCTGCTGCTACTGCTGCTGCTGCCGCCACGCGTCCTGCCT

GCCGCCCCTTCGTCCGTCCCCCGCGGCCGGCAGCTCCCGGGGCGTCTGGGCTGCCTGCTC

GAGGAGGGCCTCTGCGGAGCGTCCGAGGCCTGTGTGAACGATGGAGTGTTTGGAAGGTGC

CAGAAGGTTCCGGCAATGGACTTTTACCGCTACGAGGTGTCGCCCGTGGCCCTGCAGCGC

CTGCGCGTGGCGTTGCAGAAGCTTTCCGGCACAGGTTTCACGTGGCAGGATGACTATACT

CAGTATGTGATGGACCAGGAACTTGCAGACCTCCCGAAAACCTACCTGAGGCGTCCTGAA

GCATCCAGCCCAGCCAGGCCCTCAAAACACAGCGTTGGCAGCGAGAGGAGGTACAGTCGG

GAGGGCGGTGCTGCCCTGGCCAACGCCCTCCGACGCCACCTGCCCTTCCTGGAGGCCCTG

TCCCAGGCCCCAGCCTCAGACGTGCTCGCCAGGACCCATACGGCGCAGGACAGACCCCCC

GCTGAGGGTGATGACCGCTTCTCCGAGAGCATCCTGACCTATGTGGCCCACACGTCTGCG

CTGACCTACCCTCCCGGGCCCCGGACCCAGCTCCGCGAGGACCTCCTGCCGCGGACCCTC

GGCCAGCTCCAGCCAGATGAGCTCAGCCCTAAGGTGGACAGTGGTGTGGACAGACACCAT

CTGATGGCGGCCCTCAGTGCCTATGCTGCCCAGAGGCCCCCAGCTCCCCCCGGGGAGGGC

AGCCTGGAGCCACAGTACCTTCTGCGTGCACCCTCAAGAATGCCCAGGCCTTTGCTGGCA

CCAGCCGCCCCCCAGAAGTGGCCTTCACCTCTGGGAGATTCCGAAGACCCCTCCAGCACA

GGCGATGGAGCACGGATTCATACCCTCCTGAAGGACCTGCAGAGGCAGCCGGCTGAGGTG

AGGGGCCTGAGTGGCCTGGAGCTGGACGGCATGGCTGAGCTGATGGCTGGCCTGATGCAA

GGCGTGGACCATGGAGTAGCTCGAGGCAGCCCTGGGAGAGCGGCCCTGGGAGAGTCTGGA

GAACAGGCGGATGGCCCCAAGGCCACCCTCCGTGGAGACAGCTTTCCAGATGACGGAGTG

CAGGACGACGATGATAGACTTTACCAAGAGGTCCATCGTCTGAGTGCCACACTCGGGGGC

CTCCTGCAGGACCACGGGTCTCGACTCTTACCTGGAGCCCTCCCCTTTGCAAGGCCCCTC

GACATGGAGAGGAAGAAGTCCGAGCACCCTGAGTCTTCCCTGTCTTCAGAAGAGGAGACT

GCCGGAGTGGAGAACGTCAAGAGCCAGACGTATTCCAAAGATCTGCTGGGGCAGCAGCCG

CATTCGGAGCCCGGGGCCGCTGCGTTTGGGGAGCTCCAAAACCAGATGCCTGGGCCCTCG

AAGGAGGAGCAGAGCCTTCCAGCGGGTGCTCAGGAGGCCCTCAGCGACGGCCTGCAATTG

GAGGTCCAGCCTTCCGAGGAAGAGGCGCGGGGCTACATCGTGACAGACAGAGACCCCCTG

CGCCCCGAGGAAGGAAGGCGGCTGGTGGAGGACGTCGCCCGCCTCCTGCAGGTGCCCAGC

AGTGCGTTCGCTGACGTGGAGGTTCTCGGACCAGCAGTGACCTTCAAAGTGAGCGCCAAT

GTCCAAAACGTGACCACTGAGGATGTGGAGAAGGCCACAGTTGACAACAAAGACAAACTG

GAGGAAACCTCTGGACTGAAAATTCTTCAAACCGGAGTCGGGTCGAAAAGCAAACTCAAG

TTCCTGCCTCCTCAGGCGGAGCAAGAAGACTCCACCAAGTTCATCGCGCTCACCCTGGTC

TCCCTCGCCTGCATCCTGGGCGTCCTCCTGGCCTCTGGCCTCATCTACTGCCTCCGCCAT

AGCTCTCAGCACAGGCTGAAGGAGAAGCTCTCGGGACTAGGGGGCGACCCAGGTGCAGAT

GCCACTGCCGCCTACCAGGAGCTGTGCCGCCAGCGTATGGCCACGCGGCCACCAGACCGA

CCTGAGGGCCCGCACACGTCACGCATCAGCAGCGTCTCATCCCAGTTCAGCGACGGGCCG

ATCCCCAGCCCCTCCGCACGCAGCAGCGCCTCATCCTGGTCCGAGGAGCCTGTGCAGTCC

AACATGGACATCTCCACCGGCCACATGATCCTGTCCTACATGGAGGACCACCTGAAGAAC

AAGAACCGGCTGGAGAAGGAGTGGGAAGCGCTGTGCGCCTACCAGGCGGAGCCCAACAGC

TCGTTCGTGGCCCAGAGGGAGGAGAACGTGCCCAAGAACCGCTCCCTGGCTGTGCTGACC

TATGACCACTCCCGGGTCCTGCTGAAGGCGGAGAACAGCCACAGCCACTCAGACTACATC

AACGCTAGCCCCATCATGGATCACGACCCGAGGAACCCCGCGTACATCGCCACCCAGGGA

CCGCTGCCCGCCACCGTGGCTGACTTTTGGCAGATGGTGTGGGAGAGCGGCTGCGTGGTG

ATCGTCATGCTGACACCCCTCGCGGAGAACGGCGTCCGGCAGTGCTACCACTACTGGCCG

GATGAAGGCTCCAATCTCTACCACATCTATGAGGTGAACCTGGTCTCCGAGCACATCTGG

TGTGAGGACTTCCTGGTGAGGAGCTTCTATCTGAAGAACCTGCAGACCAACGAGACGCGC

ACCGTGACGCAGTTCCACTTCCTGAGTTGGTATGACCGAGGAGTCCCTTCCTCCTCAAGG

TCCCTCCTGGACTTCCGCAGAAAAGTAAACAAGTGCTACAGGGGCCGTTCTTGTCCAATA

ATTGTTCATTGCAGTGACGGTGCAGGCCGGAGCGGCACCTACGTCCTGATCGACATGGTT

CTCAACAAGATGGCCAAAGGTGCTAAAGAGATTGATATCGCAGCGACCCTGGAGCACTTG

AGGGACCAGAGACCCGGCATGGTCCAGACGAAGGAGCAGTTTGAGTTCGCGCTGACAGCC

GTGGCTGAGGAGGTGAACGCCATCCTCAAGGCCCTTCCCCAGTGAGCGGCAGCCTCAGGG

GCCTCAGGGGAGCCCCCACCCCACGGATGTTGTCAGGAATCATGATCTGACTTTAATTGT

GTGTCTTCTATTATAACTGCATAGTAATAGGGCCCTTAGCTCTCCCGTAGTCAGCGCAGT

TTAGCAGTTAAAAGTGTATTTTTGTTTAATCAAACAATOATAAAGAGAGATTTGTGGAAA

AATCCAGTTACGGGTGGAGGGGAATCGGTTCATCAATTTTCACTTGCTTAAAAAAAATAC

TTTTTCTTAAAGCACCCGTTCACCTTCTTGGTTGAAGTTGTGTTAACAATGCAGTAGCCA

GCACGTTCGAGGCGGTTTCCAGGAAGAGTGTGCTTGTCATCTGCCACTTTCGGGAGGGTG

GATCCACTGTGCAGGAGTGGCCGGGGAAGCTGGCAGCACTCAGTGAGGCCGCCCGGCACA

CAAGGCACGTTTGGCATTTCTCTTTGAGAGAGTTTATCATTGGGAGAAGCCGCGGGGACA

GAACTGAACGTCCTGCAGCTTCGGGGCAAGTGAGACAATCACAGCTCCTCGCTGCGTCTC

CATCAACACTGCGCCGGGTACCATGGACGGCCCCGTCAGCCACACCTGTCAGCCCAAGCA

GAGTGATTCAGGGGCTCCCCGGGGGCAGACACCTGTGCACCCCATGAGTAGTGCCCACTT

GAGGCTGGCACTCCCCTGACCTCACCTTTGCAAAGTTACAGATGCACCCCAACATTGAGA

TGTGTTTTTAATGTTAAAATATTGATTTCTACGTTATGAAAACAGATGCCCCCGTGAATG

CTTACCTGTGAGATAACCACAACCAGGAAGAACAAATCTGGGCATTGAGCAAGCTATGAG

GGTCCCCGGGAGCACACGAACCCTGCCAGGCCCCCGCTGGCTCCTCCAGGCACGTCCCGG

ACCTGTGGGGCCCCAGAGAGGGGACATTTCCCTCCTGGGAGAGAAGGAGATCAGGGCAAC

TCGGAGAGGGCTGCGAGCATTTCCCTCCCGGGAGAGGAGATCAGGGCGACCTGCACGCAC

TGCGTAGAGCCTGGAAGGGAAGTGAGAAACCAGCCGACCGGCCCTGCCCCTCTTCCCGGG

ATCACTTAATGAACCACGTGTTTTGACATCATGTAAACCTAAGCACGTAGAGATGATTCG

GATTTGACAAAATAACATTTGAGTATCCGATTCGCCATCACCCCCTACCCCAGAAATAGG

ACAATTCACTTCATTGACCAGGATGATCACATGGAAGGCGGCGCAGAGGCAGCTGTGTGG

GCTGCAGATTTCCTGTGTGGGGTTCAGCGTAGAAAACGCACCTCCATCCCGCCCTTCCCA

CAGCATTCCTCCATCTTAGATAGATGGTACTCTCCAAAGGCCCTACCAGAGGGAACACGG

CCTACTGAGCGGACAGAATGATGCCAAAATATTGCTTATGTCTCTACATGGTATTGTAAT

GAATATCTGCTTTAATATAGCTATCATTTCTTTTCCAAAATTACTTCTCTCTATCTGGAA

TTTAATTAATCGAAATGAATTTATCTGAATATAGGAAGCATATGCCTACTTGTAATTTCT

AACTCCTTATGTTTGAAGAGAAACCTCCGGTGTGAGATATACAAATATATTTAATTGTGT

CATATTAAACTTCTGATTCAAAAAAAA

>BC002551
GGCACGAGGCCACGAGCTGTTGTGCATCCAGAGGTGGAATTGGGGCCCGGCATTCCCTCC

TCGTCCCGGGCTGGCCCTTGCCCCCACCCTGCAACTCCTGGTTGAGATGGGCTCAGCCAA

GAGCGTCCCAGTCACACCAGCGCGGCCTCCGCCGCACAACAAGCATCTGGCTCGAGTGGC

GGACCCCCGTTCACCTAGTGCTGGCATCCTGCGCACTCCCATCCAGGTGGAGAGCTCTCC

ACAGCCAGGCCTACCAGCAGGGGAGCAACTGGAGGGTCTTAAACATGCCCAGGACTCAGA

TCCCCGCTCTCCTACTCTTGGTATTGCACGGACACCTATGAAGACCAGCAGTGGAGACCC

CCCAAGCCCACTGGTGAAACAGCTGAGTGAAGTATTTGAAACTGAAGACTCTAAATCAAA

TCTTCCCCCAGAGCCTGTTCTGCCCCCAGAGGCACCTTTATCTTCTGAATTGGACTTGCC

TCTGGGTACCCAGTTATCTGTTGAGGAACAGATGCCACCTTGGAACCAGACTGAGTTCCC

CTCCAAACAGGTGTTTTCCAAGGAGGAAGCAAGACAGCCCACAGAAACCCCTGTGGCCAG

CCAGAGCTCCGACAAGCCCTCAAGGGACCCTGAGACTCCCAGATCTTCAGGTTCTATGCG

CAATAGATGGAAACCAAACAGCAGCAAGGTACTAGGGAGATCCCCCCTCACCATCCTGCA

GGATGACAACTCCCCTGGCACCCTGACACTACGACAGGGTAAGCGGCCTTCACCCCTAAG

TGAAAATGTTAGTGAACTAAAGGAAGGAGCCATTCTTGGAACTGGACGACTTCTGAAAAC

TGGAGGACGAGCATGGGAGCAAGGCCAGGACCATGACAAGGAAAATCAGCACTTTCCCTT

GGTGGAGAGCTAGGCCCTGCATGGCCCCAGCAATGCAGTCACCCAGGGCCTGGTGATATC

TGTGTCCTCTCACCCCTTCTTTCCCAGGGATACTGAGGAATGGCTTGTTTTCTTAGACTC

CTCCTCAGCTACCAAACTGGGACTCACAGCTTTATTGGGCTTTCTTTGTGTCTTGTGTGT

TTCTTTTATATTAAAGGAAGTAATTTTAAATGTTACTTTAAAAAGGTAAAAAAAAAAAAA

AAAAAAAA

>AL039118
GCATTCGTAGTAAAGGTGCCCAAGAAATTATTTTGGCCATTTATTGTTTTGTCCTTTTCT

TTAAAGAACTGTTTTTTTTTCTTTTGTTTACTTTTAGACCAAAGATTGGGTTCTAGAAAA

TGCACTTGGTATACTAAGTATTAAAACAAACAAAAAGGAAAGTTGTTTCAGTTGGCAACA

CTGCCCATTCAATTGAATCAGAAGGGGACAAAATTAACGATTGCCTTCAGTTTGTGTTGT

GTATATTTTGATGTATGTGGTCACTAACAGGTCACTTTTATTTTTTCTAAATGTAGTGAA

ATGTTAATACCTATTGTACTTATAGGTAAACCTTGCAAATATGTAACCTGTGTTGCGCAA

ATGCCGCATAAATTTGAGTGATTGTTAATGTTGTCTTAAAATTTCTTGATTGTGATACTG

TGGTCATATGCCCGTGTTTGTCACTTACAAAAATGTTTACTATGAACACACAGAAATAAA

AAATAGGCTAAATTCATATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>NM_000198
GAGGCAGTAAGGACTTGGACTCCTCTGTCCAGCTTTTAACAATCTAAGTTACGGTTACCC

TCTTCTGGGTCACGCTAGAATCAGATCTGCTCTCCAGCATCTTCTGTTTCCTGGCAAGTG

TTTCCTGCTACTTTGGATTGGCCACGATGGGCTGGAGCTGCCTTGTGACAGGAGCAGGAG

GGCTTCTGGGTCAGAGGATCGTCCGCCTGTTGGTGGAAGAGAAGGAACTGAAGGAGATCA

GGGCCTTGGACAAGGCCTTCAGACCAGAATTGAGAGAGGAATTTTCTAAGCTCCAGAACA

GGACCAAGCTGACTGTACTTGAAGGAGACATTCTGGATGAGCCATTCCTGAAAAGAGCCT

GCCAGGACGTCTCGGTCGTCATCCACACCGCCTGTATCATTGATGTCTTTGGTGTCACTC

ACAGAGAGTCCATCATGAATGTCAATGTGAAAGGTACCCAGCTACTGTTGGAGGCCTGTG

TCCAAGCCAGTGTGCCAGTCTTCATCTACACCAGTAGCATAGAGGTAGCCGGGCCCAACT

CCTACAAGGAAATCATCCAGAACGGCCACGAAGAAGAGCCTCTGGAAAACACATGGCCCA

CTCCATACCCGTACAGCAAAAAGCTTGCTGAGAAGGCTGTGCTGGCGGCTAATGGGTGGA

ATCTAAAAAATGGTGATACCTTGTACACTTGTGCGTTAAGACCCACATATATCTATGGGG

AAGGAGGCCCATTCCTTTCTGCCAGTATAAATGAGGCCCTGAACAACAATGGGATCCTGT

CAAGTGTTGGAAAGTTCTCTACAGTCAACCCAGTCTATGTTGGCAACGTGGCCTGGGCCC

ACATTCTGGCCTTGAGGGCTCTGCGGGACCCCAAGAAGGCCCCAAGTGTCCGAGGTCAAT

TCTATTACATCTCAGATGACACGCCTCACCAAAGCTATGATAACCTTAATTACATCCTGA

GCAAAGAGTTTGGCCTCCGCCTTGATTCCAGATGGAGCCTTCCTTTAACCCTGATGTACT

GGATTGGCTTCCTGCTGGAAGTAGTGAGCTTCCTACTCAGCCCAATTTACTCCTATCAAC

CCCCCTTCAACCGCCACACAGTCACATTATCAAATAGTGTGTTCACCTTCTCTTACAAGA

AGGCTCAGCGAGATCTGGCGTATAAGCCACTCTACAGCTGGGAGGAAGCCAAGCAGAAAA

CCGTGGAGTGGGTTGGTTCCCTTGTGGACCGGCACAAGGAGACCCTGAAGTCCAAGACTC

AGTGATTTAAGGATGACAGAGATGTGCATGTGGGTATTGTTAGGAAATGTCATCAAACTC

CACCCACCTGGCTTCATACAGAAGGCAACAGGGGCACAAGCCCAGGTCCTGCTGCCTCTC

TTTCACACAATGCCCAACTTACTGTCTTCTTCATGTCATCAAAATCTGCACAGTCACTGG

CCCAACCAGAACTTTCTGTCCTAATCATACACCAGAAGACAAACAATATGATTTGCTGTT

ACCAAATCTCAGTGGCTGATTCTGAACAATTGTGGTCTCTCTTAACTTGAGGTTCTCTTT

TGACTAATAGAGCTCCATTTCCCCTCTTAAATGAGAAAGCATTTCTTTTCTCTTTAATCT

CCTATTCCTTCACACAGTTCAACATAAAGAGCAATAAATGTTTTAATGCTTAA

>H05388
AAATTTTGACCCCATATAAAGAAATGTGTTATGTATGTTGTGCCTCCTTAGAGACATAAA

TTTAGTGTCAAAACATGGGAGATGGCTTACTCAGAAGCATACTCCACTTAACATACCATG

GCCTGAGCTAAGTACCATGTCCTGTTTGTGTCTTATTTTTAAATATTTTCTTTGTCCACA

TGGGCCGTTGACCTTAGAGTTAAGGCGGTTGCTTTTTTGAAGAAATCACCAAAGTTTCTG

GGAAACTATGTTCAAGGTTGAAATGGAGAGTAGATTTAATTTTATTTGTCTTGTAGGGAA

GAAATCTTCCTTTGAACCGCTTTTCTTGCTTTTTCCCTTTTTCCCAAACTAGGTTACAGG

TTCTTATCTGCAAGGTTCAAGTTGCTTAGACATTGTTTTCCAGTATTCTGCAGGGCCAGT

CAGTTGTACAGAAGTTGGAATATTCTGTTCCAGAATTAAAGAAGTTTTTAGATTATGAAA

TATTATGATAATAAAGCTATATTTCTGAAAAAAAAAAA

>NM_004062
GAAGGAGCTCTCTTCTTGCTTGGCAGCTGGACCAAGGGAGCCAGTCTTGGGCGCTGGAGG

GCCTGTCCTGACCATGGTCCCTGCCTGGCTGTGGCTGCTTTGTGTCTCCGTCCCCCAGGC

TCTCCCCAAGGCCCAGCCTGCAGAGCTGTCTGTGGAAGTTCCAGAAAACTATGGTGGAAA

TTTCCCTTTATACCTGACCAAGTTGCCGCTGCCCCGTGAGGGGGCTGAAGGCCAGATCGT

GCTGTCAGGGGACTCAGGCAAGGCAACTGAGGGCCCATTTGCTATGGATCCAGATTCTGG

CTTCCTGCTGGTGACCAGGGCCCTGGACCGAGAGGAGCAGGCAGAGTACCAGCTACAGGT

CACCCTGGAGATGCAGGATGGACATGTCTTGTGGGGTCCACAGCCTGTGCTTGTGCACGT

GAAGGATGAGAATGACCAGGTGCCCCATTTCTCTCAAGCCATCTACAGAGCTCGGCTGAG

CCGGGGTACCAGGCCTGGCATCCCCTTCCTCTTCCTTGAGGCTTCAGACCGGGATGAGCC

AGGCACAGCCAACTCGGATCTTCGATTCCACATCCTGAGCCAGGCTCCAGCCCAGCCTTC

CCCAGACATGTTCCAGCTGGAGCCTCGGCTGGGGGCTCTGGCCCTCAGCCCCAAGGGGAG

CACCAGCCTTGACCACGCCCTGGAGAGGACCTACCAGCTGTTGGTACAGGTCAAGGACAT

GGGTGACCAGGCCTCAGGCCACCAGGCCACTGCCACCGTGGAAGTCTCCATCATAGAGAG

CACCTGGGTGTCCCTAGAGCCTATCCACCTGGCAGAGAATCTCAAAGTCCTATACCCGCA

CCACATGGCCCAGGTACACTGGAGTGGGGGTGATGTGCACTATCACCTGGAGAGCCATCC

CCCGGGACCCTTTGAAGTGAATGCAGAGGGAAACCTCTACGTGACCAGAGAGCTGGACAG

AGAAGCCCAGGCTGAGTACCTGCTCCAGGTGCGGGCTCAGAATTCCCATGGCGAGGACTA

TGCGGCCCCTCTGGAGCTGCACGTGCTGGTGATGGATGAGAATGACAACGTGCCTATCTG

CCCTCCCCGTGACCCCACAGTCAGCATCCCTGAGCTCAGTCCACCAGGTACTGAAGTGAC

TAGACTGTCAGCAGAGGATGCAGATGCCCCCGGCTCCCCCAATTCCCACGTTGTGTATCA

GCTCCTGAGCCCTGAGCCTGAGGATGGGGTAGAGGGGAGAGCCTTCCAGGTGGACCCCAC

TTCAGGCAGTGTGACGCTGGGGGTGCTCCCACTCCGAGCAGGCCAGAACATCCTGCTTCT

GGTGCTGGCCATGGACCTGGCAGGCGCAGAGGGTGGCTTCAGCAGCACGTGTGAAGTCGA

AGTCGCAGTCACAGATATCAATGATCACGCCCCTGAGTTCATCACTTCCCAGATTGGGCC

TATAAGCCTCCCTGAGGATGTGGAGCCCGGGACTCTGGTGGCCATGCTAACAGCCATTGA

TGCTGACCTCGAGCCCGCCTTCCGCCTCATGGATTTTGCCATTGAGAGGGGAGACACAGA

AGGGACTTTTGGCCTGGATTGGGAGCCAGACTCTGGGCATGTTAGACTCAGACTCTGCAA

GAACCTCAGTTATGAGGCAGCTCCAAGTCATGAGGTGGTGGTGGTGGTGCAGAGTGTGGC

GAAGCTGGTGGGGCCAGGCCCAGGCCCTGGAGCCACCGCCACGGTGACTGTGCTAGTGGA

GAGAGTGATGCCACCCCCCAAGTTGGACCAGGAGAGCTACGAGGCCAGTGTCCCCATCAG

TGCCCCAGCCGGCTCTTTCCTGCTGACCATCCAGCCCTCCGACCCCATCAGCCGAACCCT

CAGGTTCTCCCTAGTCAATGACTCAGAGGGCTGGCTCTGCATTGAGAAATTCTCCGGGGA

GGTGCACACCGCCCAGTCCCTGCAGGGCGCCCAGCCTGGGGACACCTACACGGTGCTTGT

GGAGGCCCAGGATACAGATGAGCCGAGACTGAGCGCTTCTGCACCCCTGGTGATCCACTT

CCTAAAGGCCCCTCCTGCCCCAGCCCTGACTCTTGCCCCTGTGCCCTCCCAATACCTCTG

CACACCCCGCCAAGACCATGGCTTGATCGTGAGTGGACCCAGCAAGGACCCCGATCTGGC

CAGTGGGCACGGTCCCTACAGCTTCACCCTTGGTCCCAACCCCACGGTGCAACGGGATTG

GCGCCTCCAGACTCTCAATGGTTCCCATGCCTACCTCACCTTGGCCCTGCATTGGGTGGA

GCCACGTGAACACATAATCCCCGTGGTGGTCAGCCACAATGCCCAGATGTGGCAGCTCCT

GGTTCGAGTGATCGTGTGTCGCTGCAACGTGGAGGGGCAGTGCATGCGCAAGGTGGGCCG

CATGAAGGGCATGCCCACGAAGCTGTCGGCAGTGGGCATCCTTGTAGGCACCCTGGTAGC

AATAGGAATCTTCCTCATCCTCATTTTCACCCACTGGACCATGTCAAGGAAGAAGGACCC

GGATCAACCAGCAGACAGCGTGCCCCTGAAGGCGACTGTCTGAATGGCCCAGGCAGCTCT

AGCTGGGAGCTTGGCCTCTGGCTCCATCTGAGTCCCCTGGGAGAGAGCCCAGCACCCAAG

ATCCAGCAGGGGACAGGACAGAGTAGAAGCCCCTCCATCTGCCCTGGGGTGGAGGCACCA

TCACCATCACCAGGCATGTCTGCAGAGCCTGGACACCAACTTTATGGACTGCCCATGGGA

GTGCTCCAAATGTCAGGGTGTTTGCCCAATAATAAAGCCCCAGAGAACTGGGCTGGGCCC

TATGGGATTGGTA

>AA782845
TCTTTACCTATGTGAAGCGAGGTGACGTGATACGTCACTGGCGCCGTCTTATAATTTAGA

TGTAAAAATCTTTAGAAACAAATAAAACTCTCTATATATGTGTATGTCTGTGTACAAAAA

AATGACAGAGCTGATGGCCAGTGTATACAGAGCGTGGCCCGCGGTGTACAATACCCATAT

AAGGTACATTGTGCAGGAGGGGAATTGCTGGCTGCTTTTACTTCCTGACCAAGACTGAAA

AATTATTTACTGAAATCTGTAAACCTTTTTATGAAACTTTTAAGCACCAGGCTGTTTACT

TACACAATTTAGGTCTGCCAGAAAATTCTATCTGTGATAGATCTGTAAAGAGGGTCAGGG

GTTAGAGTTTACTATTTTTGAAGTTTACATTGTTACATATGAAATGGAAACATTATTTTG

AAACGTTGTCATAACCCAATGGTGCATTCTGTAACCATGGAGTCTTCTGTTTCCTGGGGG

AAAGGGGCATTCATGACCTGAACTTTTTAGCAAATTATTATTCTCAGTTTCCATTACCTG

TTTGGCCAAACAGATTAATAAAATATTTGAAAAAGAAGCAATAAAAAAAAAA

>AI457360
CTGAGAAAGTCCGGTCCCTATAAGGGGACATCAGTGCGAGACCTGCTCCGTGCTGTGAGN

ACAAGAGGCACCATACAAGNAAGCTCCCAGTTGAGGTGCGACAGGCACTCGCCNAAGTCC

NTGATGGCTTCGTCCAGTACTCACAAAACGGCTCCCCCCGGCTGGTCCTTCACACGCACC

GAGCCATGAGGAGCTGGCGCCTCTGAGAGCCTCTTCCTGCCCTACTACCCGCCAGACTCA

GAGGCCAGGAGGCCATGCCCTGGGGCCACAGGGAGGTGAGGTGGGCTGGATGCCACACAG

ATGGTCTCCGTGCTGGCTCACTGAAGAGCTGAGCCTGTGGCTGGCCTCAGAATCAGGCTG

GGTGCAGTGGCTCACACCTGTAATCCCAGCATTTTGGGAGGCTGAGTGAGAGGATCACTT

GAGCTCAGGAGTTCGAGACCAGCCTGGCCAACATGGCAACACCCCATTTCTACAAAAAAT

TTGTAAAATTAGCCAGGCATGGTGGCGCACGCCTGTAGTCCCAGCTGCTTGGGAGGCTGA

GGTGGGAGAATCACTTGAGCCCAGGAGTTCGAGGCTGCAGTGAGCCAGGATCATGCCACT

GCACTCCAGCCTGGTCCACAGAGAGACACTGTCACCCCCTTTCCCCCACAAGACTGGCAG

AGGCTGGGCAGCCTGGGGCTGATGAAGCAGAGATGTTCGCTGGATCCCAGGCCCTGGCAC

CCCTCAGGAAATACAAGAAAAAGAATATTCACATCTGTTTAATGTGCATAAAGCCAAGGA

AAGGACAGTTCCGAATTCAAAAAAAAAAAAAAAAAAAA

>BF446419
TTTTTTTTTTTTTTTTTAAATATTTAACTTATTTATTTAACAAAGTAGAAGGGAATCCAT

TGCTAGCTTTTCTGTGTTGGTGTCTAATATTTGGGTAGGGTGGGGGATCCCCAACAATCA

GGTCCCCTGAGATAGCTGGTCATTGGGCTGATCATTGCCAGAATCTTCTTCTCCTGGGGT

CTGGCCCCCCAAAATGCCTAACCCAGGACCTTGGGAATTCTACTCATCCCAAATGATAAT

TCCAAATGCTGTTACCCAAGGTTAGGGTGTTGAAGGAAGGTAGAGGGTGGGGCTTCAGGT

CTCAACGGCTTCCCTAACCACCCCTCTTCTCTTGGCCCAGCCTGGTTCCCCCCACTTCCA

CTCCCCTCTACTCTCTCTAGGACTGGGCTGATGAAGGCACTGCCCAAAATTTCCCCTACC

CCCAACTTTCCCCTACCCCCAACTTTCCCCACCAGCTCCACAACCCTGTTTGGAGCTACT

GCAGGACCAGAAGCACAAAGTGCGGTTTCCCAAGCCTTTGTCCATCTCAGCCCCCAGAGT

ATATCTGTGCTTGGGGAATCTCACACAGAAACTCAGGAGCACCCCCTGCCTGAGCTAAGG

GAGGTCTTATCTCTCAGGGGGGGTTTAAGTGCCGTTTGCAATAATGTCGTCTTATTTATT

TAGCGGGGTGAATATTTTATACTGTAAGTGAGCAATCAGAGTATAATGTTTATGGTGACA

AAATTAAAGGCTTTCTTATATGTTTAAAAAAAA

>BC006819
GCCTTATAAAGCACCAAGAGGCTGCCAGTGGGACATTTTCTCGGCCCTGCCAGCCCCCAG

GAGGAAGGTGGGTCTGAATCTAGCACCATGACGGAACTAGAGACAGCCATGGGCATGATC

ATAGACGTCTTTTCCCGATATTCGGGCAGCGAGGGCAGCACGCAGACCCTGACCAAGGGG

GAGCTCAAGGTGCTGATGGAGAAGGAGCTACCAGGCTTCCTGCAGAGTGGAAAAGACAAG

GATGCCGTGGATAAATTGCTCAAGGACCTGGACGCCAATGGAGATGCCCAGGTGGACTTC

AGTGAGTTCATCGTGTTCGTGGCTGCAATCACGTCTGCCTGTCACAAGTACTTTGAGAAG

GCAGGACTCAAATGATGCCCTGGAGATGTCACAGATTCCTGGCAGAGCCATGGTCCCAGG

CTTCCCAAAAGTGTTTGTGGCAATTATTCCCCTAGGCTGAGCCTGCTCATGTACCTCTGA

TTAATAAATGCTTATGAAATGAAAAAAAAAAAAAAA

>AA765597
CCAGCAAAGTCTCTTTTGACCACACGCTTTATCCGAGATGCTTAGAAGTATATTTGGCTG

TTTTATTTGCATCTTTGATTAAGATGTCTATCATTGTAAAAAGGTATTCAAAACAAAAGT

GTACTCTTTTATTATTATGAATCACATTGTACTGAGCTGTGAAGTCAGTGTTTTAAAAAT

GTAGAGTTTATTCATGGAGCATGCCATTGAGGTTTGGATGGTGGCAGGTAAAACAGAAAG

GCAAGATGTCATCTGACATTAGGCTACTTATAAATAAATGTTTATCTAGCTTTTATTTCA

TGCCCTAATGAATAAAACATGCTTCGAAAAAGAAAGTAAAAAAAAAAAACAAAA

>X78202
GGCGAGAGAGACGCTCCCGCTCGCCGCCAGCTCTGATTGGCCCAGCGGTAGGAAAGGTTA

AACCAAAAATTTTTTTACAGCCCTAGTGTGCGCCTGTAGCTCGGAAAATTAATTGTGGCT

ATAGCCGCCTCGATCGCTGTCTCCCCAGCCTCGCCGCGGACGCTCCGGGACGCGCCCGCC

CGCCGCCCGGTTCTCCCCCCCTTTGGGCTGGTGCTGCTGCTGCTGTGACTGCTGCTGCGA

AAGGAGGAGGAGGAGGAGGAAGCAGCGGGGGGGGGAGCGGTGGGTGTGGGGGAAACCAAG

AGTACAGTGGACGAGGACTCACCCCGGCGTGGTGTTCTTTTTTCTTCTTCTTTTTCTTTC

CTTTTTTTTTTTTTTTTCTAATTCCTGAGGGGTGGTTGCTGCTTTTGCTACATGACTTGC

CAGCGCCCGAGCCTGCGGTCCAACTGCGCTGCTGCCGGAGCGCTCAGTGCCGCCGCTGCC

GCCCGTGCCCCCCGCGCCCCGTTCGGCACCCACCGGTCGCCGCCCCGCCCGCGCGCCGCT

GTCCCGCTCCCGCGCCGCCGCCGCCGTTTCCCCCCGACGACTGGGTGATGCTGGACATGG

GAGATAGGAAAGAGGTGAAAATGATCCCCAAGTCCTCGTTCAGCATCAACAGCCTGGTGC

CCGAGGGCCTCCAGAACGACAACCACCACGCGAGCCACGGCCACCACAACAGCCACCACC

CCCAGCACCACCACCACCACCACCACCATCACCACCACCCGCCGCCGCCCGCCCCGCAAC

CGCCGCCGCCGCCGCAGCAGCAGCAGCCGCCGCCGCCGCCGAGACGCGGGGCCCGGCGCC

GACGACGACGAGGCCCCAGCAGTTGTTGTTCCGCCGCGCACGCACACGGCGCGCCTGAGG

GCCAACGGCAGCTGGCGCAAGGCGACCGGCGCGGCCGGGGGATCTGCCCCGTCGGGCCGG

ACGAGAAGGAGAAGGCCCGCGCCGGGGGGGAGGAGAAGAAGGGGGCGGGCGAGGGCGGCA

AGGACGGGGAGGGGGGCAAGGAGGGCGAGAAGAAGAACGGCAAGTACGAGAAGCCGCCGT

TCAGCTACAACGCGCTCATCATGATGGCCATGCGGCAGAGCCCCGAGAAGCGGCTCACGC

TCAACGGCATCTACGAGTTCATCATGAAGAACTTCCCTTACTACCGCGAGAACAAGCAGG

GCTGGCAGAACTCCATCCGCCACAATCTGTCCCTCAACAAGTGCTTCGTGAAGGTGCCGC

GCCACTACGACGACCCGGGCAAGGGCAACTACTGGATGCTGGACCCGTCGAGCGACGACG

TGTTCATCGGCGGCACCACGGGCAAGCTGCGGCGCTCCACCACCTCGCCGGCCAAGCCGG

CCTTCAAGCGCGGTGCCGCGCTCACCTCCACCGGCCTCACCTTCATGGACGCGCCGGCTC

CCTCTACTGGCCCATGTCGCCCTTCCTGTCCCTGCACCACCCCCGCCAGCAGCACTTTGA

GTTACAACGGGACCACGTCGGCCTACCCCAGCCACCCCATGCCCTACAGCTCCGTGTTGA

CTCAAAACTCGCTGGGCAACAACCACTCCTCCTCCACCGCCAACGGGCTGAGCGTGGACC

GGCTGGTCAACGGGGGAATCCCGTACGCCACGCACCACCTCACGGCCGCCGCGCTAACCG

CCTCGGTGCCCTGCGGCCTGCTGGTGCCCTGCTCTGGGACCTACTCCCTCAACCCCTGCT

CCGTCAACCTGCTCGCGGGCCAGACCAGTTACTTTTTCCCCCACGTCCCGCACCCGTCAA

TGACTTCGCAGAGCAGCACGTCCATGAGCGCCAGGGCCGCGTCCTCCTCCACGTCGCCGG

CAGGCCCCCCTCGACCCCTGCCCTGTGAGTCTTTAAGACCCTCTTTGCCAAGTTTTACGA

CGGGACTGTCTGGGGGACTGTCTGATTATTTCACACATCAAAATCAGGGGTCTTCTTCCA

ACCCTTTAATACATTAACATCCCTGGGACCAGACTGTAAGTGAACGTTTTACACACATTT

GCATTGTAAATGATAATTAAAAAAATAAGTCCAGGTATTTTTTATTAAGCCCCCCCCTCC

CATTTCTGTACGTTTGTTCAGTCTCTAGGGTTGTTTATTATTCTAACAAGGTGTGGAGTG

TCAGCGAGGTGCAATGTGGGGAGAATACATTGTAGAATATAAGGTTTGGAAGTCAAATTA

TAGTAGAATGTGTATCTAAATAGTGACTGCTTTGCCATTTCATTCAAACCTGACAAGTCT

ATCTCTAAGAGCCGCCAGATTTCCATGTGTGCAGTATTATAAGTTATCATGGAACTATAT

GGTGGACGCAGACCTTGAGAACAACCTAAATTATGGGGAGAATTTTAAAATGTTAAACTG

TAATTTGTATTTAAAAAGCATTCGTAGTAAAGGTGCCCAAGAAATTATTTTGGCCATTTA

TTGTTTTCTCCTTTTCTTTAAAGAACTGTTTTTTTTTCTTTTGTTTACTTTTAGACCAAA

GATTGGGCGGTTCTAGAAAATGCGCCTTGGTATACTAAGTATTAAAACAAACAAAAAGGA

AAGTTGTTTCAGTTAACGCTGCCCATTCAATTGAATCAGAAGGGGACAAAATTAACGATT

GCCTTCAGTTTGTGTTGTGTATATTTTGATGTATGTGGTCACTAACAGGTCACTTTTATT

TTTTCTAAATGTAGTGAAATGTTAATACCTATTGTACTTATAGGTAAACCTTGCAAATAT

GTAACCTGTGTTGCGCAAATGCCGCATAAATTTGAGTGATTGTTAATGTTGTCTTAAAAT

TTCTTGATTGTGACTATGTGGTCATATGCCCGTGTTTGTCACTTACAAAAATGTTTACTA

TGAACACACATAAATAAAAAATAG

>AK026790
AAAATGCTTACTCTTGTGGGCTACTTGTTGTGTGGAAAAAGGAAAACGGATTCATTTTCC

CATCGGCGACTTTATGACGACAGAAATGAACCAGTTCTGCGATTAGACAATGCACCGGAA

CCTTATGATGTGAGTTTTGGGAATTCTAGCTACTACAATCCAACTTTGAATGATTCAGCC

ATGCCAGAAAGTGAAGAAAATGCACGTGATGGCATTCCTATGGATGACATACCTCCACTT

CGTACTTCTGTATAGAACTAACAGCAAAAAGGCGTTAAACAGCAAGTGTCATCTACATCC

TAGCCTTTTGACAAATTCATCTTTCAAAAGGTTACACAAAATTACTGTCACGTTGGATTT

TGTCAAGGAGAATCATAAAAGCAGGAGACCAGTAGCAGAAATGTAGACAGGATGTATCAT

CCAAAGGTTTTCTTTCTTACAATTTTTGGCCATCCTGAGGCATTTACTAAGTAGCCTTAA

TTTGTATTTTAGTAGTATTTTCTTAGTAGAAAATATTTGTGGAATCAGATAAAACTAAAA

GATTTCACCATTACAGCCCTGCCTCATAACTAAATAATAAAAATTATTCCACCAAAAAAT

TCTAAAACAATGAAGATGACTCTTTACTGCTCTGCCTGAAGCCCTAGTACCATAATTCAA

GATTGCATTTTCTTAAATGAAAATTGAAAGGGTGCTTTTTAAAGAAAATTTGACTTAAAG

CTAAAAAGAGGACATAGCCCAGAGTTTCTGTTATTGGGAAATTGAGGCAATAGAAATGAC

AGACCTGTATTCTAGTACGTTATAATTTTCTAGATCAGCACACACATGATCAGCCCACTG

AGTTATGAAGCTGACAATGACTGCATTCAACGGGGCCATGGCAGGAAAGCTGACCCTACC

CAGGAAAGTAATAGCTTCTTTAAAAGTCTTCAAAGGTTTTGGGAATTTTAACTTGTCTTA

ATATATCTTAGGCTTCAATTATTTGGGTGCCTTAAAAACTCAATGAGAATCATGGTAAAA

AAAAAAAGTTAACCAAAGAATATACCTGTACATAATTTGTACAGTTTTAAGTTGTTAGAT

AGGAACTGGATTTCTTATGTATTAGACATTATTGCTCAATCATAATGGAATAGATTCTGC

ATCCCTAAATGTATGAACCATAAGGTTAAAAAAGATGAATGGAAATATCAAACAACTTTT

CACTGAGCATCAGTTTCATAATCAATAATATAAGAAGATTAATTTGGATTCTAGTATGTT

TCAGTTTGTTTTTAATTACCACCTTCCTTTGGTAGAAAAAATATGTTCCTTGATGTAGGA

AAGTCTAGGTTTTAGAGATTAGAGGATGAGATCAAGAGTTAAATTCCTAAAGAAGCACTG

AATATATGAAGAGAGCAAACAAATCAAGTACCAACCTAGAGGCTTTATTTTTGAATTGAT

TCATGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAACACAGAAACAGCT

TTCAGAAAATAAGGGATAGAAAGTAATGAAGAAAGTACTTACCCCATATTGCCATAAAAA

TAGCAAAGAAGACTGTCCCTCCATTATCGAACAAATATGTCACCTGAGTAGAAAACAAAC

AGAAATATTAGTCATGCAAATTGATTATAATAAGCCAGTGAATACTGTTTGCACTCAGGT

ACTATGATTTTTTCTCAAATAGAATCATATTATTTTATAGTACAGAAATATTATATATGA

ATTCCTTTCATGGGTCTTGCAACAATTTCACATGATTTTTCTCATGGGGAGAGGTGAAGA

AACAACATTAGCCCTCTTCTCTCCTCTCTTGATTCCCTTTATACCCCACCATCATTTCTG

ATTATAAATAATTCTACCATTCTATGGAAGTATTTGTGGGTCACAGATTGTCAAACTACT

TAATGAAAGTTGTATGAAATTAGTTTTTCAGGTGAGGCATTCCTAGTTGCAATTCCTGTT

AGCAAAACTTCTAGGAGTGGGGAAGTTGGAAAATGCAGGATTCTTCCAGTGAGCCAGCAT

TTCCCATAGCTAACCCTATTCTCTTAGTCTTTCAAAATGTAGAATGGGTCCAATAATGGC

TATAAGATGTAATAAATCCCATCTTAATTTGTTTTAAAAGTTTCATAAATCACTGAACAC

TTATGAAACAAAGTGTTTTTTAATCAGATATCAACTGAAACTTCATAAAGGATGCATAGT

TTTATAATGTTATTGAATCAAATTTTAAGGCTTGTATTGTTTGATTTTAATAAAGTATAA

TCTCCTTTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>BC012727
GGCACGAGGCTGCCTGCCCCCCGGGTGGGGCTGCGGCTCTGGCCTCCCAGGCCCATCCTC

AACAGCTACCCCAGCCAACACCAAGGCCACAAGGGGACCCCGGCCTAGGAGGCAGGAAGC

CAAGGTACAGAGAGCAGCCTGGCCCTCACCAGTGCGCAAGCTGGGGCAGCAAGGCTGACA

GTTGCTGCATGCCCAGGGCAGGGTGTGGTACTGGCACCCAAGTTCAGCATGGCAGAGCTG

GCCAACAGCTTGTCCCCGATCTGCCTCCAGCCCCAAGATGCCTACAGCCCCCAGGCCCCT

TCGGCAGCACTGCCTCTGCCCACCTGCCTTTAAGAGACTCCAGGGCTGCTCCTGTCATGC

AGCGAAGGTTTTGTCTGTTTCAAAGTTCGAGACTCAACTTGAGGGACTGTTTTTGACAAT

CCCCGCTGACCTCCGCTCCTCGTGGCGCCCTGGCCCTACACCCAGCCTGGCCCAGGGCCG

GCTTTGCCTGGTGAGGCTGGAGGGAGCACCAGGACCTGCTGTCTGCTGTCAGCCCCTCCT

GGTGCTGGTGCCCTGATGCTGTGCCTTGTCACCCATTGAGCTGCAAGAGGGACCAAGAGG

GGGCCACGCAGCCAGCCAGATGCCTGGCCCTGTGCTGGGGCAGACAACGCTGCAGAGCCC

AGGGAGCCTGGCGCTAGGACGTGCGTCCTTGTGACACTGGCCTGTCTGAACTCACCTGGC

CTGGGAAGCACCGTCTGCCCGGGCCCAAGCCCTGCCCCTCCAGAGTCCAGAGCCAGGAAG

GGGCTGCTGAGGGCGAGCATCCTGCTGGGCTCTCTGCCCGGCCCACCCCTCCAAGGGGCT

GGCCTGTGAGCCTTGACTGGGATTCATGATGTGGAGGCCCCCAACTTCCAGAAGCAGCTG

GTACTCTGCTCACACAAGCGACTGGGCCGGCCGGCCCTGGACCCCTAGACCCCGAGCCGC

CTGCCGACTGCCTGCACAGGGAGAGCAGTTGAGGCCCGGGCAGGGCCCCCACACCAGACC

CCAACATAGCTTCCCCACCCAGGCACCCCCTCCCGGGGCAGCAGGCGTGGGAGTCAGGGC

TGCATGCTCCTCCCCTCCCACCTCACAGGCGGCCTTAGGCAAGTCATTTTCTGTCATCAC

AAGGTCGCCTCTGCCTAGTCAGGTCCTGGCGTCCAGAGTAAGGATGTGCGGCCCCCAGGC

CCCCGCACACCTCCCTCAGCACCAAGACCGGGACCCCCCCACCCACGTGTCTCATTGTGG

CTGCCTATGGACTCCCGGGCCTTGTGTGCAGGCCAGGCCCTTCCACTGATTTTTTAAAGT

GAACCATTGCTGGATCTCAGATTCTGTGGCATCTAAGGCCTAGCAGGGGTGGGCACACGG

GTCACCCGAGGCCCATACCAAGACTCTGTTCCTGCCCTAGGCCCAGTCTCAAAGGAAGCC

ACAAGGCGCGGGGGCCACTGAGGAAGGAAATGTTCATTTTCATTTGTCCAAAACCACCTT

AAGTTTTAAGTATATTAATCTTGATGCTTTTTAACTATTGCTTTTTAACTTGCTGAGATT

TAGAAATACTGTTATAAAAACTTTTTTAATTTCTGTATTTTTTTTCTGTATTGTATCTTC

ATGGGACATTAGGGGTTTTCTATGGTAAGCACACCTATGGTTTTGGTAAAAACATTATCA

AATATATATCCAGACGGTTCTTCCCTAGAAGAAAAACAAGTCTTTACACCTGATAAAATA

TTTTGCGAAGAGAGGTGTTCTTTTTCCTTACTGGTGCTGAAAGGAAGGATGGATAACGAG

GAGAAAATAAAACTGTGAGGCTCAAAAAAAAAAAAAAAAAA

>R45389
CCTGCCCTTCTCTATATGTACCATCTCCAAAAACCATGTACATCTCCAAAAACTGGAGTA

GAAAGTTAGATTGCTCAACTACAACTCCTCTAGAACTCTATAGCTCTGACATACAGATTC

ACACTCTCCTCTATTTGCTAAGTATGTAAAGAATGTTTTCTTTTAAAATGTTCTCTTTTG

AGAACAACTGCTTATTTGTTATAAAAGCATTTGGTTAAAATGATGTCATCATAAAGAACA

GTGGCTTTGTTTCAATACATATTTTTGAGATGATTATCTAGAAGCCAGATTAATAAAATC

AGCTTGTGACCTTGCTAAGCATATAAACTGGAAATTCAGATACATTCAAAATTATGGGTT

CATTTAAAAGTGTTCTACCTTTTGGGTATGAGACTAATATCACTAATTCCTCAATAGTTA

TCATGGCTCTATCTTAATTAATTAGAAAATATGTGTGTTTAATTCTTTGAGAATTAAAAT

AGAGAATATTAACAGAGGGTTAAAAACTGCTTCAACTCCAATAAGATAAAGGAAGCTCAA

AATCTATGAGCTGAGTGTTCAATTAGCTTTGCCTACTGAGTTCAATTTTATGTCAATACA

ACAGTGGATCAGACAGTACGACTTTGAACTGGTGAATGTAAACAATTGTTTTTCACCTAA

GCTGCTTTGGAAGAACTGATGCTTGCTGCTAACTAAAGTTTTGGATGTATCGATTTAGAG

AACCAATTAATACCTGCAAAATAAAGCATACTGTGGTACTTCTGTTTGATCTAGTATGTG

TGATTTTAGATTGATGGATTAAAAATTAATAAAGATCATACATTCCATACCAAAAAAAAA

AAAAAAAA

>BC006811
CCAGAAGCCTGCATTTCTGCATTCTGCTTAATTCCCTTTCCTTAGATTTGAAAGAAGCCA

ACACTAAACCACAAATATACAACAAGGCCATTTTCTCAAACGAGAGTCAGCCTTTAACGA

AATGACCATGGTTGACACAGAGATGCCATTCTGGCCCACCAACTTTGGGATCAGCTCCGT

GGATCTCTCCGTAATGGAAGACCACTCCCACTCCTTTGATATCAAGCCCTTCACTACTGT

TGACTTCTCCAGCATTTCTACTCCACATTACGAAGACATTCCATTCACAAGAACAGATCC

AGTGGTTGCAGATTACAAGTATGACCTGAAACTTCAAGAGTACCAAAGTGCAATCAAAGT

GGAGCCTGCATCTCCACCTTATTATTCTGAGAAGACTCAGCTCTACAATAAGCCTCATGA

AGAGCCTTCCAACTCCCTCATGGCAATTGAATGTCGTGTCTGTGGAGATAAAGCTTCTGG

ATTTCACTATGGAGTTCATGCTTGTGAAGGATGCAAGGGTTTCTTCCGGAGAACAATCAG

ATTGAAGCTTATCTATGACAGATGTGATCTTAACTGTCGGATCCACAAAAAAAGTAGAAA

TAAATGTCAGTACTGTCGGTTTCAGAAATGCCTTGCAGTGGGGATGTCTCATAATGCCAT

CAGGTTTGGGCGGATGCCACAGGCCGAGAAGGAGAAGCTGTTGGCGGAGATCTCCAGTGA

TATCGACCAGCTGAATCCAGAGTCCGCTGACCTCCGGGCCCTGGCAAAACATTTGTATGA

CTCATACATAAAGTCCTTCCCGCTGACCAAAGCAAAGGCGAGGGCGATCTTGACAGGAAA

GACAACAGACAAATCACCATTCGTTATCTATGACATGAATTCCTTAATGATGGGAGAAGA

TAAAATCAAGTTCAAACACATCACCCCCCTGCAGGAGCAGAGCAAAGAGGTGGCCATCCG

CATCTTTCAGGGCTGCCAGTTTCGCTCCGTGGAGGCTGTGCAGGAGATCACAGAGTATGC

CAAAAGCATTCCTGGTTTTGTAAATCTTGACTTGAACGACCAAGTAACTCTCCTCAAATA

TGGAGTCCACGAGATCATTTACACAATGCTGGCCTCCTTGATGAATAAAGATGGGGTTCT

CATATCCGAGGGCCAAGGCTTCATGACAAGGGAGTTTCTAAAGAGCCTGCGAAAGCCTTT

TGGTGACTTTATGGAGCCCAAGTTTGAGTTTGCTGTGAAGTTCAATGCACTGGAATTAGA

TGACAGCGACTTGGCAATATTTATTGCTGTCATTATTCTCAGTGGAGACCGCCCAGGTTT

GCTGAATGTGAAGCCCATTGAAGACATTCAAGACAACCTGCTACAAGCCCTGGAGCTCCA

GCTGAAGCTGAACCACCCTGAGTCCTCACAGCTGTTTGCCAAGCTGCTCCAGAAAATGAC

AGACCTCAGACAGATTGTCACGGAACACGTGCAGCTACTGCAGGTGATCAAGAAGACGGA

GACAGACATGAGTCTTCACCCGCTCCTGCAGGAGATCTACAAGGACTTGTACTAGCAGAG

AGTCCTGAGCCACTGCCAACATTTCCCTTCTTCCAGTTGCACTATTCTGAGGGAAAATCT

GACACCTAAGAAATTTACTGTGAAAAAGCATTTTAAAAAGAAAAGGTTTTAGAATATGAT

CTATTTTATGCATATTGTTTATAAAGACACATTTACAATTTACTTTTAATATTAAAAATT

ACCATATTATGAAAAAAAAAAAAAAAA

>X05615
GCAGTGGTTTCTCCTCCTTCCTCCCAGGAAGGGCCAGGAAAATGGCCCTGGTCCTGGAGA

TCTTCACCCTGCTGGCCTCCATCTGCTGGGTGTCGGCCAATATCTTCGAGTACCAGGTTG

ATGCCCAGCCCCTTCGTCCCTGTGAGCTGCAGAGGGAAACGGCCTTTCTGAAGCAAGCAG

ACTACGTGCCCCAGTGTGCAGAGGATGGCAGCTTCCAGACTGTCCAGTGCCAGAACGACG

GCCGCTCCTGCTGGTGTGTGGGTGCCAACGGCAGTGAAGTGCTGGGCAGCAGGCAGCCAG

GACGGCCTGTGGCTTGTCTGTCATTTTGTCAGCTACAGAAACAGCAGATCTTACTGAGTG

GCTACATTAACAGCACAGACACCTCCTACCTCCCTCAGTGTCAGGATTCAGGGGACTACG

CGCCTGTTCAGTGTGATGTGCAGCATGTCCAGTGCTGGTGTGTGGACGCAGAGGGGATGG

AGGTGTATGGGACCCGCCAGCTGGGGAGGCCAAAGCGATGTCCAAGGAGCTGTGAAATAA

GAAATCGTCGTCTTCTCCACGGGGTGGGAGATAAGTCACCACCCCAGTGTTCTGCGGAGG

GAGAGTTTATGCCTGTCCAGTGCAAATTTGTCAACACCACAGACATGATGATTTTTGATC

TGGTCCACAGCTACAACAGGTTTCCAGATGCATTTGTGACCTTCAGTTCCTTCCAGAGGA

GGTTCCCTGAGGTATCTGGGTATTGCCACTGTGCTGACAGCCAAGGGCGGGAACTGGCTG

AGACAGGTTTGGAGTTGTTACTGGATGAAATTTATGACACCATTTTTGCTGGCCTGGACC

TTCCTTCCACCTTCACTGAAACCACCCTGTACCGGATACTGCAGAGACGGTTCCTCGCAG

TTCAATCAGTCATCTCTGGCAGATTCCGATGCCCCACAAAATGTGAAGTGGAGCGGTTTA

CAGCAACCAGCTTTGGTCACCCCTATGTTCCAAGCTGCCGCCGAAATGGCGACTATCAGG

CGGTGCAGTGCCAGACGGAAGGGCCCTGCTGGTGTGTGGACGCCCAGGGGAAGGAAATGC

ATGGAACCCGGCAGCAAGGGGAGCCGCCATCTTGTGCTGAAGGCCAATCTTGTGCCTCCG

AAAGGCAGCAGGCCTTGTCCAGACTCTACTTTGGGACCTCAGGCTACTTCAGCCAGCACG

ACCTGTTCTCTTCCCCAGAGAAAAGATGGGCCTCTCCAAGAGTAGCCAGATTTGCCACAT

CCTGCCCACCCACGATCAAGGAGCTCTTTGTGGACTCTGGGCTTCTCCGCCCAATGGTGG

AGGGACAGAGCCAACAGTTTTCTGTCTCAGAAAATCTTCTCAAAGAAGCCATCCGAGCAA

TTTTTCCCTCCCGAGGGCTGGCTCGTCTTGCCCTTCAGTTTACCACCAACCCAAAGAGAC

TCCAGCAAAACCTTTTTGGAGGGAAATTTTTGGTGAATGTTGGCCAGTTTAACTTGTCTG

GAGCCCTTGGCACAAGAGGCACATTTAACTTCAGTCAATTTTTCCAGCAACTTGGTCTTG

CAAGCTTCTTGAATGGAGGGAGACAAGAAGATTTGGCCAAGCCACTCTCTGTGGGATTAG

ATTCAAATTCTTCCACAGGAACCCCTGAAGCTGCTAAGAAGGATGGTACTATGAATAAGC

CAACTGTGGGCAGCTTTGGCTTTGAAATTAACCTACAAGAGAACCAAAATGCCCTCAAAT

TCCTTGCTTCTCTCCTGGAGCTTCCAGAATTCCTTCTCTTCTTGCAACATGCTATCTCTG

TGCCAGAAGATGTGGCAAGAGATTTAGGTGATGTGATGGAAACGGTACTCGACTCCCAGA

CCTGTGAGCAGACACCTGAAAGGCTATTTGTCCCATCATGCACGACAGAAGGAAGCTATG

AGGATGTCCAATGCTTTTCCGGAGAGTGCTGGTGTGTGAATTCCTGGGGCAAAGAGCTTC

CAGGCTCAAGAGTCAGAGATGGACAGCCAAGGTGCCCCACAGACTGTGAAAAGCAAAGGG

CTCGCATGCAAAGCCTCATGGGCAGCCAGCCTGCTGGCTCCACCTTGTTTGTCCCTGCTT

GTACTAGTGAGGGACATTTCCTGCCTGTCCAGTGCTTCAACTCAGAGTGCTACTGTGTTG

ATGCTGAGGGTCAGGCCATTCCTGGAACTCGAAGTGCAATAGGGAAGCCCAAGAAATGCC

CCACGCCCTGTCAATTACAGTCTGAGCAAGCTTTCCTCAGGACGGTGCAGGCCCTGCTCT

CTAACTCCAGCATGCTACCCACCCTTTCCGACACCTACATCCCACAGTGCAGCACCGATG

GGCAGTGGAGACAAGTGCAATGCAATGGGCCTCCTGAGCAGGTCTTCGAGTTGTACCAAC

GATGGGAGGCTCAGAACAAGGGCCAGGATCTGACGCCTGCCAAGCTGCTAGTGAAGATCA

TGAGCTACAGAGAAGCAGCTTCCGGAAACTTCAGTCTCTTTATTCAAAGTCTGTATGAGG

CTGGCCAGCAAGATGTCTTCCCGGTGCTGTCACAATACCCTTCTCTGCAAGATGTCCCAC

TAGCAGCACTGGAAGGGAAACGGCCCCAGCCCAGGGAGAATATCCTCCTGGAGCCCTACC

TCTTCTGGCAGATCTTAAATGGCCAACTCAGCCAATACCCGGGGTCCTACTCAGACTTCA

GCACTCCTTTGGCACATTTTGATCTTCGGAACTGCTGGTGTGTGGATGAGGCTGGCCAAG

AACTGGAAGGAATGCGGTCTGAGCCAAGCAAGCTCCCAACGTGTCCTGGCTCCTGTGAGG

AAGCAAAGCTCCGTGTACTGCAGTTCATTAGGGAAACGGAAGAGATTGTTTCAGCTTCCA

ACAGTTCTCGGTTCCCTCTGGGGGAGAGTTTCCTGGTGGCCAAGGGAATCCGGCTGAGGA

ATGAGGACCTCGGCCTTCCTCCGCTCTTCCCGCCCCGGGAGGCTTTCGCGGAGTTTCTGC

GTGGGAGTGATTACGCCATTCGCCTGGCGGCTCAGTCTACCTTAAGCTTCTATCAGAGAC

GCCGCTTTTCCCCGGACGACTCGGCTGGAGCATCCGCCCTTCTGCGGTCGGGCCCCTACA

TGCCACAGTGTGATGCGTTTGGAAGTTGGGAGCCTGTGCAGTGCCACGCTGGGACTGGGC

ACTGCTGGTGTGTAGATGAGAAAGGAGGGTTCATCCCTGGCTCACTGACTGCCCGCTCTC

TGCAGATTCCACAGTGCCCGACAACCTGCGAGAAATCTCGAACCAGTGGGCTGCTTTCCA

GTTGGAAACAGGCTAGATCCCAAGAAAACCCATCTCCAAAAGACCTGTTCGTCCCAGCCT

GCCTAGAAACAGGAGAATATGCCAGGCTGCAGGCATCGGGGGCTGGCACCTGGTGTGTGG

ACCCTGCATCAGGAGAAGAGTTGCGGCCTGGCTCGAGCAGCAGTGCCCAGTGCCCAAGCC

TCTGCAATGTGCTCAAGAGTGGAGTCCTCTCTAGGAGAGTCAGCCCAGGCTATGTCCCAG

CCTGCAGGGCAGAGGATGGGGGCTTTTCCCCAGTGCAATGTGACCAGGCCCAGGGCAGCT

GCTGGTGTGTCATGGACAGCGGAGAAGAGGTGCCTGGGACGCGCGTGACCGGGGGCCAGC

CCGCCTGTGAGAGCCCGCGGTGTCCGCTGCCATTCAACGCGTCGGAGGTGGTTGGTGGAA

CAATCCTGTGTGAGACAATCTCGGGCCCCACAGGCTCTGCCATGCAGCAGTGCCAATTGC

TGTGCCGCCAAGGCTCCTGGAGCGTGTTTCCACCAGGGCCATTGATATGTAGCCTGGAGA

GCGGACGCTGGGAGTCACAGCTGCCTCAGCCCCGGGCCTGCCAACGGCCCCAGCTGTGGC

AGACCATCCAGACCCAAGGGCACTTTCAGCTCCAGCTCCCGCCGGGCAAGATGTGCAGTG

CTGACTACGCGGGTTTGCTGCAGACTTTCCAGGTTTTCATATTGGATGAGCTGACAGCCC

GCGGCTTCTGCCAGATCCAGGTGAAGACTTTTGGCACCCTGGTTTCCATTCCTGTCTGCA

ACAACTCCTCTGTGCAGGTGGGTTGTCTGACCAGGGAGCGTTTAGGAGTGAATGTTACAT

GGAAATCACGGCTTGAGGACATCCCAGTGGCTTCTCTTCCTGACTTACATGACATTGAGA

GAGCCTTGGTGGGCAAGGATCTCCTTGGGCGCTTCACAGATCTGATCCAGAGTGGCTCAT

TCCAGCTTCATCTGGACTCCAAGACGTTCCCAGCGGAAACCATCCGCTTCCTCCAAGGGG

ACCACTTTGGCACCTCTCCTAGGACACGGTTTGGGTGCTCGGAAGGATTCTACCAAGTCT

TGACAAGTGAGGCCAGTCAGGACGGACTGGGATGCGTTAAGTGCCATGAAGGAAGCTATT

CCCAAGATGAGGAATGCATTCCTTGTCCTGTTGGATTCTACCAAGAACAGGCAGGGAGCT

TGGCCTGTGTCCCATGTCCTGTGGGCAGAACGACCATTTCTGCCGGAGCTTTCAGCCAGA

CTCACTGTGTCACTGACTGTCAGAGGAACGAAGCAGGCCTGCAATGTGACCAGAATGGCC

AGTATCGAGCCAGCCAGAAGGACAGGGGCAGTGGGAAGGCCTTCTGTGTGGACGGCGAGG

GGCGGAGGCTGCCATGGTGGGAAACAGAGGCCCCTCTTGAGGACTCACAGTGTTTGATGA

TGCAGAAGTTTGAGAAGGTTCCAGAATCAAAGGTGATCTTCGACGCCAATGCTCCTGTGG

CTGTCAGATCCAAAGTTCCTGATTCTGAGTTCCCCGTGATGCAGTGCTTGACAGATTGCA

CAGAGGACGAGGCCTGCAGCTTCTTCACCGTGTCCACGACGGAGCCAGAGATTTCCTGTG

ATTTCTATGCTTGGACAAGTGACAATGTTGCCTGCATGACTTCTGACCAGAAACGAGATG

CACTGGGGAACTCAAAGGCCACCAGCTTTGGAAGTCTTCGCTGCCAGGTGAAAGTGAGGA

GCCATGGTCAAGATTCTCCAGCTGTGTATTTGAAAAAGGGCCAAGGATCCACCACAACAC

TTCAGAAACGCTTTGAACCCACTGGTTTCCAAAACATGCTTTCTGGATTGTACAACCCCA

TTGTGTTCTCAGCCTCAGGAGCCAATCTAACCGATGCTCACCTCTTCTGTCTTCTTGCAT

GCGACCGTGATCTGTGTTGCGATGGCTTCGTCCTCACACAGGTTCAAGGAGGTGCCATCA

TCTGTGGGTTGCTGAGCTCACCCAGTGTCCTGCTTTGTAATGTCAAAGACTGGATGGATC

CCTCTGAAGCCTGGGCTAATGCTACATGTCCTGGTGTGACATATGACCAGGAGAGCCACC

AGGTGATATTGCGTCTTGGAGACCAGGAGTTCATCAAGAGTCTGACACCCTTAGAAGGAA

CTCAAGACACCTTTACCAATTTTCAGCAGGTTTATCTCTGGAAAGATTCTGACATGGGGT

CTCGGCCTGAGTCTATGGGATGTAGAAAAAACACAGTGCCAAGGCCAGCATCTCCAACAG

AAGCAGGTTTGACAACAGAACTTTTCTCCCCTGTGGACCTCAACCAGGTCATTGTCAATG

GAAATCAATCACTATCCAGCCAGAAGCACTGGCTTTTCAAGCACCTGTTTTCAGCCCAGC

AGGCAAACCTATGGTGCCTTTCTCGTTGTGTGCAGGAGCACTCTTTCTGTCAGCTCGCAG

AGATAACAGAGAGTGCATCCTTGTACTTCACCTGCACCCTCTACCCAGAGGCACAGGTGT

GTGATGACATCATGGAGTCCAATACCCAGGGCTGCAGACTGATCCTGCCTCAGATGCCAA

AGGCCCTGTTCCGGAAGAAAGTTATACTGGAAGATAAAGTGAAGAACTTTTACACTCGCC

TGCCGTTCCAAAAACTGATGGGGATATCCATTAGAAATAAAGTGCCCATGTCTGAAAAAT

CTATTTCTAATGGGTTCTTTGAATGTGAACGACGGTGCGATGCGGACCCATGCTGCACTG

GCTTTGGATTTCTAAATGTTTCCCAGTTAAAAGGAGGAGAGGTGACATGTCTCACTCTGA

ACAGCTTGGGAATTCAGATGTGCAGTGAGGAGAATGGAGGAGCCTGGCGCATTTTGGACT

GTGGCTCTCCTGACATTGAAGTCCACACCTATCCCTTCGGATGGTACCAGAAGCCCATTG

CTCAAAATAATGCTCCCAGTTTTTGCCCTTTGGTTGTTCTGCCTTCCCTCACAGAGAAAG

TGTCTCTGGAATCGTGGCAGTCCCTGGCCCTCTCTTCAGTGGTTGTTGATCCATCCATTA

GGCACTTTGATGTTGCCCATGTCAGCACTGCTGCCACCAGCAATTTCTCTGCTGTCCGAG

ACCTCTGTTTGTCGGAATGTTCCCAACATGAGGCCTGTCTCATCACCACTCTGCAAACCC

AACTCGGGGCTGTGAGATGTATGTTCTATGCTGATACTCAAAGCTGCACACATAGTCTGC

AGGGTCGGAACTGCCGACTTCTGCTTCGTGAAGAGGCCACCCACATCTACCGGAAGCCAG

GAATCTCTCTGCTCAGCTATGAGGCATCTGTACCTTCTGTGCCCATTTCCACCCATGGCC

GGCTGCTGGGCAGGTCCCAGGCCATCCAGGTGGGTACCTCATGGAAGCAAGTGGACCAGT

TCCTTGGAGTTCCATATGCTGCCCCGCCCCTGGCAGAGAGGCACTTCCAGGCACCAGAGC

CCTTGAACTGGACAGGCTCCTGGGATGCCAGCAAGCCAAGGGCCAGCTGCTGGCAGCCAG

GCACCAGAACATCCACGTCTCCTGGAGTCAGTGAAGATTGTTTGTATCTCAATGTGTTCA

TCCCTCAGAATGTGGCCCCTAACGCGTCTGTGCTGGTGTTCTTCCACAACACCATGGACA

GGGAGGAGAGTGAAGGATGGCCGGCTATCGACGGCTCCTTCTTGGCTGCTGTTGGCAACC

TCATCGTGGTCACTGCCAGCTACCGAGTGGGTGTCTTCGGCTTCCTGAGTTCTGGATCCG

GAGAGGTGAGTGGCAACTGGGGGCTGCTGGACCAGGTGGCGGCTCTGACCTGGGTGCAGA

CCCACATCCGAGGATTTGGCGGGGACCCTCGGCGCGTGTCCCTGGCAGCAGACCGTGGCG

GGGCTGATGTGGCCAGCATCCACCTTCTCACGGCCAGGGCCACCAACTCCCAACTTTTCC

GGAGAGCTGTGCTGATGGGAGGCTCCGCACTCTCCCCGGCCGCCGTCATCAGCCATGAGA

GGGCTCAGCAGCAGGCAATTGCTTTGGCAAAGGAGGTCAGTTGCCCCATGTCATCCAGCC

AAGAAGTGGTGTCCTGCCTCCGCCAGAAGCCTGCCAATGTCCTCAATGATGCCCAGACCA

AGCTCCTGGCCGTGAGTGGCCCTTTCCACTACTGGGGTCCTGTGATCGATGGCCACTTCC

TCCGTGAGCCTCCAGCCAGAGCACTGAAGAGGTCTTTATGGGTAGAGGTCGATCTGCTCA

TTGGGAGTTCTCAGGACGACGGGCTCATCAACAGAGCAAAGGCTGTGAAGCAATTTGAGG

AAAGTCGAGGCCGGACCAGTAGCAAAACAGCCTTTTACCAGGCACTGCAGAATTCTCTGG

GTGGCGAGGACTCAGATGCCCGCGTCGAGGCTGCTGCTACATGGTATTACTCTCTGGAGC

ACTCCACGGATGACTATGCCTCCTTCTCCCGGGCTCTGGAGAATGCCACCCGGGACTACT

TTATCATCTGCCCTATAATCGACATGGCCAGTGCCTGGGCAAAGAGGGCCCGAGGAAACG

TCTTCATGTACCATGCTCCTGAAAACTACGGCCATGGCAGCCTGGAGCTGCTGGCGGATG

TTCAGTTTGCCTTGGGGCTTCCCTTCTACCCAGCCTACGAGGGGCAGTTTTCTCTGGAGG

AGAAGAGCCTGTCGCTGAAAATCATGCAGTACTTTTCCCACTTCATCAGATCAGGAAATC

CCAACTACCCTTATGAGTTCTCACGGAAAGTACCCACATTTGCAACCCCCTGGCCTGACT

TTGTACCCCGTGCTGGTGGAGAGAACTACAAGGAGTTCAGTGAGCTGCTCCCCAATCGAC

AGGGCCTGAAGAAAGCCGACTGCTCCTTCTGGTCCAAGTACATCTCGTCTCTGAAGACAT

CTGCAGATGGAGCCAAGGGCGGGCAGTCAGCAGAGAGTGAAGAGGAGGAGTTGACGGCTG

GATCTGGGCTAAGAGAAGATCTCCTAAGCCTCCAGGAACCAGGCTCTAAGACCTACAGCA

AGTGACCAGCCCTTGAGCTCCCCAAAAACCTCACCCGAGGCTGCCCACTATGGTCATCTT

TTTCTCTAAAATAGTTACTTACCTTCAATAAAGTATCTACATGCGGTG

>X79676
AGATCTCTCCAGATCACACTGTCACGTGTACCTAGCACATCTCGAGAACTCCTTTGGGCC

GTCTGGGGCCCGGGAAGGAAGCCTGAGTTCTCAAGATTCCAGGACTGAGAGTGCCAGCTT

GTCTCAAAGCCAGGTCAATGGTTTCTTTGCCAGCCATTTAGGTGACCAAACCTGGCAGGA

ATCACAGCATGGCAGCCCTTCCCCATCTGTAATATCCAAAGCCACCGAGAAAGAGACTTT

CACTGATAGTAACCAAAGCAAAACTAAAAAGCCAGGCATTTCTGATGTAACTGATTACTC

AGACCGTGGAGATTCAGACATGGATGAAGCCACTTACTCCAGCAGTCAGGATCATCAAAC

ACCAAAACAGGAATCTTCCTCTTCAGTGAATACATCCAACAAGATGAATTTTAAAACTTT

TCCTTCATCACCTCCTAGGTCTGGAGATATCTTTGAGGTTGAACTGGCTAAAAATGATAA

CAGCTTGGGGATAAGTGTCACGGGAGGTGTGAATACGAGTGTCAGACATGGTGGCATTTA

TGTGAAAGCTGTTATTCCCCAGGGAGCAGCAGAGTCTGATGGTAGAATTCACAAAGGTGA

TCGCGTCCTAGCTGTCAATGGAGTTAGTCTAGAAGGAGCCACCCATAAGCAAGCTGTGGA

AACACTGAGAAATACAGGACAGGTGGTTCATCTGTTATTAGAAAAGGGACAATCTCCAAC

ATCTAAAGAACATGTCCCGGTAACCCCACAGTGTACCCTTTCAGATCAGAATGCCCAAGG

TCAAGGCCCAGAAAAAGTGAAGAAAACAACTCAGGTCAAAGACTACAGCTTTGTCACTGA

AGAAAATACATTTGAGGTAAAATTATTTAAAAATAGCTCAGGTCTAGGATTCAGTTTTTC

TCGAGAAGATAATCTTATACCGGAGCAAATTAATGCCAGCATAGTAAGGGTTAAAAAGCT

CTTTCCTGGACAGCCAGCAGCAGAAAGTGGAAAAATTGATGTAGGAGATGTTATCTTGAA

AGTGAATGGAGCCTCTTTGAAAGGACTATCTCAGCAGGAAGTCATATCTGCTCTCAGGGG

AACTGCTCCAGAAGTATTCTTGCTTCTCTGCAGACCTCCACCTGGTGTGCTACCGGAAAT

TGATACTGCGCTTTTGACCCCACTTCAGTCTCCAGCACAAGTACTTCCAAACAGCAGTAA

AGACTCTTCTCAGCCATCATGTGTGGAGCAAAGCACCAGCTCAGATGAAAATGAAATGTC

AGACAAAAGCAAAAAACAGTGCAAGTCCCCATCCAGAAAAGACAGTTACAGTGACAGCAG

TGGGAGTGGAGAAGATGACTTAGTGACAGCTCCAGCAAACATATCAAATTCGACCTGGAG

TTCAGCTTTGCATCAGACTCTAAGCAACATGGTATCACAGGCACAGAGTCATCATGAAGC

ACCAAGAGTCAAGAAGATACCATTTGTACCATGTTTTACTATCCTCAGGAAAAGGCCCAA

TAAACCAGAGTTTGAGGACAGTAATCCTTCCCCTCTACCACCGGATATGGCTCCTGGGCA

GAGTTATCAACCCCAATCAGAATCTGCTTCCTCTAGTTCGATGGATAAGTATCATATACA

TCACATTTCTGAACCAACTAGACAAGAAAACTGGACACCTTTGAAAAATGACTTGGAAAA

TCACCTTGAAGACTTTGAACTGGAAGTAGAACTCCTCATTACCCTAATTAAATCAGAAAA

AGGAAGCCTGGGTTTTACAGTAACCAAAGGCAATCAGAGAATTGGTTGTTATGTTCATGA

TGTCATACAGGATCCAGCCAAAAGTGATGGAAGGCTAAAACCTGGGGACCGGCTCATAAA

GGTTAATGATACAGATGTTACTAATATGACTCATACAGATGCAGTTAATCTGCTCCGGGG

ATCCAAAACAGTCAGATTAGTTATTGGACGAGTTCTAGAATTACCCAGAATACCAATGTT

GCCTCATTTGCTACCGGACATAACACTAACGTGCAACAAAGAGGAGTTGGGTTTTTCCTT

ATGTGGAGGTCATGACAGCCTTTATCAAGTGGTATATATTAGTGATATTAATCCAAGGTC

CGTCGCAGCCATTGAGGGTAATCTCCAGCTATTAGATGTCATCCATTATGTGAACGGAGT

CAGCACACAAGGAATGACCTTGGAGGAAGTTAACAGAGCATTAGACATGTCACTTCCTTC

ATTGGTATTGAAAGCAACAAGAAATGATCTTCCAGTGGTCCCCAGCTCAAAGAGGTCTGC

TGTTTCAGCTCCAAAGTCAACCAAAGGCAATGGTTCCTACAGTGTGGGGTCTTGCAGCCA

GCCTGCCCTCACTCCTAATGATTCATTCTCCACGGTTGCTGGGGAAGAAATAAATGAAAT

ATCGTACCCCAAAGGAAAATGTTCTACTTATCAGATAAAGGGATCACCAAACTTGACTCT

GCCCAAAGAATCTTATATACAAGAAGATGACATTTATGATGATTCCCAAGAAGCTGAAGT

TATCCAGTCTCTGCTGGATGTTGTGGATGAGGAGTCCCAGAATCTTTTAAACGAAAATAA

TGCAGCAGGATACTCCTGTGGTCCAGGTACATTAAAGATGAATGGGAAGTTATCAGAAGA

GAGAACAGAAGATACAGACTGCGATGGTTCACCTTTACCTGAGTATTTTACTGAGGCCAC

CAAAATGAATGGCTGTGAAGAATATTGTGAAGAAAAAGTAAAAAGTGAAAGCTTAATTCA

GAAGCCACAAGAAAAGAAGACTGATGATGATGAAATAACATGGGGAAATGATGAGTTGCC

AATAGAGAGAACAAACCATGAAGATTCTGATAAAGATCATTCCTTTCTGACAAACGATGA

GCTCGCTGTACTCCCTGTCGTCAAAGTGCTTCCCTCTGGTAAATACACGGGCGCCAACTT

AAAATCAGTCATTCGAGTCCTGCGGGTTGCTAGATCAGGAATTCCTTCTAAGGAGCTGGA

GAATCTTCAAGAATTAAAACCTTTGGATCAGTGTCTAATTGGGCAAACTAAGGAAAACAG

AAGGAAGAACAGATATAAAAATATACTTCCCTATGATGCTACAAGAGTGCCTCTTGGAGA

TGAAGGTGGCTATATCAATGCCAGCTTCATTAAGATACCAGTTGGGAAAGAAGAGTTCGT

TTACATTGCCTGCCAAGGACCACTGCCTACAACTGTTGGAGACTTCTGGCAGATGATTTG

GGAGCAAAAATCCACAGTGATAGCCATGATGACTCAAGAAGTAGAAGGAGAAAAAATCAA

ATGCCAGCGCTATTGGCCCAACATCCTAGGCAAAACAACAATGGTCAGCAACAGACTTCG

ACTGGCTCTTGTGAGAATGCAGCAGCTGAAGGGCTTTGTGGTGAGGGCAATGACCCTTGA

AGATATTCAGACCAGAGAGGTGCGCCATATTTCTCATCTGAATTTCACTGCCTGGCCAGA

CCATGATACACCTTCTCAACCAGATGATCTGCTTACTTTTATCTCCTACATGAGACACAT

CCACAGATCAGGCCCAATCATTACGCACTGCAGTGCTGGCATTGGACGTTCAGGGACCCT

GATTTGCATAGATGTGGTTCTGGGATTAATCAGTCAGGATCTTGATTTTGACATCTCTGA

TTTGGTGCGCTGCATGAGACTACAAAGACACGGAATGGTTCAGACAGAGGATCAATATAT

TTTCTGCTATCAAGTCATCCTTTATGTCCTGACACGTCTTCAAGCAGAAGAAGAGCAAAA

ACAGCAGCCTCAGCTTCTGAAGTGACATGAAAAGAGCCTCTGGATGCATTTCCATTTCTC

TCCTTAACCTCCAGCAGACTCCTGCTCTCTATCCAAAATAAAGATCACAGAGCAGCAAGT

TCATACAACATGCATGTTCTCCTCTATCTTAGAGGGGTATTCTTCTTGAAAATAAAAAAT

ATTGAAATGCTGTATTTTTACAGCTACTTTAACCTATGATAATTATTTACAAAATTTTAA

CACTAACCAAACAATGCAGATCTTAGGGATGATTAAAGGCAGCATTTGATGATAGCAGAC

ATTGTTACAAGGACATGGTGAGTCTATTTTTAATGCACCAATCTTGTTTATAGCAAAAAT

GTTTTCCAATATTTTAATAAAGTAGTTATTTATAGGCATACTTGAAACCAGTATTTAAGC

TTTAAATGACAGTAATATTGGCATAGAAAAAAGTAGCAAATGTTTACTGTATCAATTTCT

AATGTTTACTATATAGAATTTCCTGTAATATATTTATATACTTTTTCATGAAAATGGAGT

TATCAGTTATCTGTTTGTTACTGCATCATCTGTTTGTAATCATTATCTCACTTTGTAAAT

AAAAACACACCTTAAAACATGAACAAGCCAAAAAAAAAAAAAAA

>NM_006142
CCAGGCAGCAGTTAGCCCGCCGCCCGCCTGTGTGTCCCCAGAGCCATGGAGAGAGCCAGT

CTGATCCAGAAGGCCAAGCTGGCAGAGCAGGCCGAACGCTATGAGGACATGGCAGCCTTC

CCAGGCAGCAGTTAGCCCGCCGCCCGCCTGTGTGTCCCCAGAGCCATGGAGAGAGCCAGT

CTGATCCAGAAGGCCAAGCTGGCAGAGCAGGCCGAACGCTATGAGGACATGGCAGCCTTC

ATGAAAGGCGCCGTGGAGAAGGGCGAGGAGCTCTCCTGCGAAGAGCGAAACCTGCTCTCA

GTAGCCTATAAGAACGTGGTGGGCGGCCAGAGGGCTGCCTGGAGGGTGCTGTCCAGTATT

GAGCAGAAAAGCAACGAGGAGGGCTCGGAGGAGAAGGGGCCCGAGGTGCGTGAGTACCGG

GAGAAGGTGGAGACTGAGCTCCAGGGCGTGTGCGACACCGTGCTGGGCCTGCTGGACAGC

CACCTCATCAAGGAGGCCGGGGACGCCGAGAGCCGGGTCTTCTACCTGAAGATGAAGGGT

GACTACTACCGCTACCTGGCCGAGGTGGCCACCGGTGACGACAAGAAGCGCATCATTGAC

TCAGCCCGGTCAGCCTACCAGGAGGCCATGGACATCAGCAAGAAGGAGATGCCGCCCACC

AACCCCATCCGCCTGGGCCTGGCCCTGAACTTTTCCGTCTTCCACTACGAGATCGCCAAC

AGCCCCGAGGAGGCCATCTCTCTGGCCAAGACCACTTTCGACGAGGCCATGGCTGATCTG

CACACCCTCAGCGAGGACTCCTACAAAGACAGCACCCTCATCATGCAGCTGCTGCGAGAC

AACCTGACACTGTGGACGGCCGACAACGCCGGGGAAGAGGGGGGCGAGGCTCCCCAGGAG

CCCCAGAGCTGAGTGTTGCCCGCCACCGCCCCGCCCTGCCCCCTCCAGTCCCCGCCCTGC

CGAGAGGACTAGTATGGGGTGGGAGGCCCCACCCTTCTCCCCTAGGCGCTGTTCTTGCTC

CAAAGGGCTCCGTGGAGAGGGACTGGCAGAGCTGAGGCCACCTGGGGCTGGGGATCCCAC

TCTTCTTGCAGCTGTTGAGCGCACCTAACCACTGGTCATGCCCCCACCCCTGCTCTCCGC

ACCCGCTTCCTCCCGACCCCAGGACCAGGCTACTTCTCCCCTCCTCTTGCCTCCCTCCTG

CCCCTGCTGCCTCTTGATTCGTAGGAATTGAGGAGTGTCTCCGCCTTGTGGCTGAGAACT

GGACAGTGGCAGGGGCTGGAGATGGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCGCG

CGCGCCAGTGCAAGACCGAGACTGAGGGAAAGCATGTCTGCTGGGTGTGACCATGTTTCC

TCTCAATAAAGTTCCCCTGTGACACTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAA

>AW445220
CGGCCGCGAGGCCCTGAGATGAGGCTCCAAAGACCCCGACAGGCCCCGGCGGGTGGGAGG

CGCGCGCCCCGGGGCGGGCGGGGCTCCCCCTACCGGCCAGACCCGGGGAGAGGCGCGCGG

AGGCTGCGAAGGTTCCAGAAGGGCGGGGAGGGGGCGCCGCGCGCTGACCCTCCCTGGGCA

CCGCTGGGGACGATGGCGCTGCTCGCCTTGCTGCTGGTCGTGGCCCTACCGCGGGTGTGG

ACAGACGCCAACCTGACTGCGAGACAACGAGATCCAGAGGACTCCCAGCGAACGGACGAG

GGTGACAATAGAGTGTGGTGTCATGTTTGTGAGAGAGAAAACACTTTCGAGTGCCAGAAC

CCAAGGAGGTGCAAATGGACAGAGCCATACTGCGTTATAGCGGCCGTGAAAATATTTCCA

CGTTTTTTCATGGTTGCGAAGCAGTGCTCCGCTGGTTGTGCAGCGATGGAGAGACCCAAG

CCAGAGGAGAAGCGGTTTCTCCTGGAAGAGCCCATGCCCTTCTTTTACCTCAAGTGTTGT

AAAATTCGCTACTGCAATTTAGAGGGGCCACCTATCAACTCATCAGTGTTCAAAGAATAT

GCTGGGAGCATGGGTGAGAGCTGTGGTGGGCTGTGGCTGGCCATCCTCCTGCTGCTGGCC

TCCATTGCAGCCGGCCTCAGCCTGTCTTGAGCCACGGGACTGCCACAGACTGAGCCTTCC

GGAGCATGGACTCGCTCCAGACCGTTGTCACCTGTTGCATTAAACTTGTTTTCTGTTGAT

TAAAAAAAAAAAAAAAAA

>AK025701
TTCAGCCGGAACGTTACTCCGTGTCCACCCGGATCGTGTGTGTGATCGAGGCTGCGGAGA

CGCCTTTCACGGGGGGTGTCGAGGTGGACGTCTTCGGGAAACTGGGCCGTTCGCCTCCCA

ATGTCCAGTTCACCTTCCAACAGCCCAAGCCTCTCAGTGTGGAGCCGCAGCAGGGACCGC

AGGCGGGCGGCACCACACTGACCATCCACGGCACCCACCTGGACACGGGCTCCCAGGAGG

ACGTGCGGGTGACCCTCAACGGCGTCCCGTGTAAAGTGACGAAGTTTGGGGCGCAGCTCC

AGTGTGTCACTGGCCCCCAGGCGACACGGGGCCAGATGCTTCTGGAGGTCTCCTACGGGG

GGTCCCCCGTGCCCAACCCCGGCATCTTCTTCACCTACCGCGAAAACCCCGTACTGCGAG

CCTTCGAGCCGCTACGAAGCTTTGCCAGTGGTGGCCGCAGCATCAACGTCACGGGTCAGG

GCTTCAGCCTGATCCAGAGGTTTGCCATGGTGGTCATCGCGGAGCCCCTGCAGTCCTGGC

AGCCGCCGCGGGAGGCTGAATCCCTGCAGCCCATGACGGTGGTGGGTACAGACTACGTGT

TCCACAATGACACCAAGGTCGTCTTCCTGTCCCCGGCTGTGCCTGAGGAGCCAGAGGTCT

ACAACCTCACGGTGCTGATCGAGATGGACGGGCACCGTGCCCTGCTCAGAACAGAGGCCG

GGGCCTTCGAGTACGTGCCTGACCCCACCCTTGAGAACTTCACAGGTGGCGTCAAGAAGC

AGGTCAACAAGCTCATCCACGCCCGGGGCACCAATCTGAACAAGGCGATGACGCTGCAGG

AGGCCGAGGCCTTCGTGGGTGCCGAGCGCTGCACCATGAAGACGCTGACGGAGACCGACC

TGTACTGTGAGCCCCCGGAGGTGCAGCCCCCGCCCAAGCGGCGGCAGAAACGAGACACCA

CACACAACCTGCCCGAGTTCATTGTGAAGTTCGGCTCTCGCGAGTGGGTGCTGGGCCGCG

TGGAGTACGACACACGGGTGAGCGACGTGCCGCTCAGCCTCATCTTGCCGCTGGTCATCG

TGCCCATGGTGGTCGTCATCGCGGTGTCTGTCTACTGCTACTGGAGGAAGAGCCAGCAGG

CCGAACGAGAGTATGAGAAGATCAAGTCCCAGCTGGAGGGCCTGGAGGAGAGCGTGCGGG

ACCGCTGCAAGAAGGAATTCACAGACCTGATGATCGAGATGGAGGACCAGACCAACGACG

TGCACGAGGCCGGCATCCCCGTGCTGGACTACAAGACCTACACCGACCGCGTCTTCTTCC

TGCCCTCCAAGGACGGCGACAAGGACGTGATGATCACCGGCAAGCTGGACATCCCCGAGC

CGCGGCGGCCGGTGGTGGAGCAGGCCCTCTACCAGTTCTCCAACCTGCTGAACAGCAAGT

CTTTCCTCATCAATTTCATCCACACCCTGGAGAACCAGCGGGAGTTCTCGGCCCGCGCCA

AGGTCTACTTCGCGTCCCTGCTGACGGTGGCGCTGCACGGGAAACTGGAGTACTACACGG

ACATCATGCACACGCTCTTCCTGGAGCTCCTGGAGCAGTACGTGGTGGCCAAGAACCCCA

AGCTGATGCTGCGCAGGTCTGAGACTGTGGTGGAGAGGATGCTGTCCAACTGGATGTCCA

TCTGCCTGTACCAGTACCTCAAGGACAGTGCCGGGGAGCCCCTGTACAAGCTCTTCAAGG

CCATCAAACATCAGGTGGAAAAGGGCCCGGTGGATGCGGTACAGAAGAAGGCCAAGTACA

CTCTCAACGACACGGGGCTGCTGGGGGATGATGTGGAGTACGCACCCCTGACGGTGAGCG

TGATCGTGCAGGACGAGGGAGTGGACGCCATCCCGGTGAAGGTCCTCAACTGTGACACCA

TCTCCCAGGTCAAGGAGAAGATCATTGACCAGGTGTACCGTGGGCAGCCCTGCTCCTGCT

GGCCCAGGCCAGACAGCGTGGTCCTGGAGTGGCGTCCGGGCTCCACAGCGCAGATCCTGT

CGGACCTGGACCTGACGTCACAGCGGGAGGGCCGGTGGAAGCGCGTCAACACCCTTATGC

ACTACAATGTCCGGGATGGAGCCACCCTCATCCTGTCCAAGGTGGGGGTCTCCCAGCAGC

CGGAGGACAGCCAGCAGGACCTGCCTGGGGAGCGCCATGCCCTCCTGGAGGAGGAGAACC

GGGTGTGGCACCTGGTGCGGCCGACCGACGAGGTGGACGAGGGCAAGTCCAAGAGAGGCA

GCGTGAAAGAGAAGGAGCGGACGAAGGCCATCACCGAGATCTACCTGACGCGGCTGCTCT

CAGTCAAGGGCACACTGCAGCAGTTTGTGGACAACTTCTTCCAGAGCGTGCTGGCGCCTG

GGCACGCGGTGCCACCTGCAGTCAAGTACTTCTTCGACTTCCTGGACGAGCAGGCAGAGA

AGCACAACATCCAGGATGAAGACACCATCCACATCTGGAAGACGAACAGTTTACCGCTCC

GGTTCTGGGTGAACATCCTCAAGAACCCCCACTTCATCTTTGACGTGCATGTCCACGAGG

TGGTGGACGCCTCGCTGTCAGTCATCGCGCAGACCTTCATGGATGCCTGCACGCGCACGG

AGCATAAGCTGAGCCGCGATTCTCCCAGCAACAAGCTGCTGTACGCCAAGGAGATCTCCA

CCTACAAGAAGATGGTGGAGGATTACTACAAGGGGATCCGGCAGATGGTGCAGGTCAGCG

ACCAGGACATGAACACACACCTGGCAGAGATTTCCCGGGCGCACACGGACTCCTTGAACA

CCCTCGTGGCACTCCACCAGCTCTACCAATACACGCAGAAGTACTATGACGAGATCATCA

ATGCCTTGGAGGAGGATCCTGCCGCCCAGAAGACGCAGCTGGCCTTCCGCCTGCAGCAGA

TTGCCGCTGCACTGGAGAACAAGGTCACTGACCTCTGACCTACAATCTCCAGTGCTGCCT

TGGGACATAGGTACCTGAGGTACCTGAGAGCCCCTCAGGGGAGGAGGCCGAGTGGCTGTG

GCTGAGGCCCCCACCCTCCCCTGGAACGCGCCCCAAGCCGGAGTGGGTGCAGCCGGAACC

CGCCCAGCGTCTAGACTGTAGCATCTTCCTCTGAGCAATACCGCCGGGCACCGCACCAGC

ACCAGCCCCAGCCCCAGCTCCCTCCGGCCGCAGAACCAGCATCGGGTGTTCACTGTCGAG

TCTCGAGTGATTTGAAAATGTGCCTTACGCTGCCACGCTGGGGGCAGCTGGCCTCCGCCT

CCGCCCACGCACCAGCAGCCGCCTCCATGCCCTAGGTTGGGCCCCTGGGGGATCTGAGGG

CCTGTGGCCCCCAGGGCAAGTTCCCAGATCCTATGTCTGTCTGTCCACCACGAGATGGGA

GGAGGAGAAAAAGCGGTACGATGCCTTCCTGACCTCACCGGCCTCCCCAAGGGTGCCGGC

ACTCTGGGTGGACTCACGGCTGCTGGGCCCCACGTCAAAGGTCAAGTGAGACGTAGGTCA

AGTCCTACGTCGGGGCCCAGACATCCTGGGGTCCTGGTCTGTCAGACAGGCTGCCCTAGA

GCCCCACCCAGTCCGGGGGGACTGGGAGCAGTTCCAAGACCACCCCACCCCTTTTTGTAA

ATCTTGTTCATTGTAAATCAAATACAGCGTCTTTTTCACTCCGAAAAAAAAAAAAAAAAA

AAAAAA

>NM_033229
GATGTGGGCACGCCTCAGAGCCAGAAGTTTATGGCTCCCACCTGCTCAATCTGACAGGAA

GCTTCTGCTCCCCAGTTCTCCCCAGCCACTGTGGTCTACAGATTCCAGGAAACCCATCCC

CCTGTGACCTCAGGGTGTGCTCTGTTCTCCACCCTAGGGACCAGAAGGAGCCAGGAGTAA

AGAACTGGCTTACTTGGCCGCCACTGGGAAATTCTGGGTAATTCGAGACGCCCTGGAATT

TGGACCCACTCCGCTGATAGGTGGTGGGCAGGGTTCTAGGGAACACAAGAGGCGGAGCCA

GGTGGCTTCCCTGTGCTGGCATTCTTGGCTCTCTCTCTCTCTCTTTCTCTCTCTCTGTCT

CTCTCTCTCTCTCTGTCTCTCAGCCTTGAAGCCGTTTCCCTCTGCGATTCATGTAAGTGT

GACTCGATTTCAGGGAAAGGGAACTCGCGTGGGCTGAGGAGACCGGAGTGGACGGGCTGG

GGAAGGCACCGTGATGCCCGCAACCCCGTCCCTGAAGGTGGTCCATGAGCTGCCTGCCTG

TACCCTCTGTGCGGGGCCGCTGGAGGATGCGGTGACCGTTCCCTGTGGACACACCTTCTG

CCGGCTCTGCCTCCCCGCGCTCTCCCAGATGGGGGCCCAATCCTCGGGCAAGATCCTGCT

CTGCCCGCTCTGCCAAGAGGAGGAGCAGGCAGAGACTCCCATGGCCCCTGTGCCCCTGGG

CCCGCTGGGAGAAACTTACTGCGAGGAGCACGGCGAGAAGATCTACTTCTTCTGCGAGAA

CGATGCCGAGTTCCTCTGTGTGTTCTGCAGGGAGGGTCCCACGCACCAGGCGCACACCGT

GGGGTTCCTGGACGAGGCCATTCAGCCCTACCGGGATCGTCTCAGGAGTCGACTGGAAGC

TCTGAGCACGGAGAGAGATGAGATTGAGGATGTAAAGTGTCAAGAAGACCAGAAGCTTCA

AGTGCTGCTGACTCAGATCGAAAGCAAGAAGCATCAGGTGGAAACAGCTTTTGAGAGGCT

GCAGCAGGAGCTGGAGCAGCAGCGATGTCTCCTGCTGGCCAGGCTGAGGGAGCTGGAGCA

GCAGATTTGGAAGGAGAGGGATGAATATATCACAAAGGTCTCTGAGGAAGTCACCCGGCT

TGGAGCCCAGGTCAAGGAGCTGGAGGAGAAGTGTCAGCAGCCAGCAAGTGAGCTTCTACA

AGATGTCAGAGTCAACCAGAGCAGGTGTGAGATGAAGACTTTTGTGAGTCCTGAGGCCAT

TTCTCCTGACCTTGTCAAGAAGATCCGTGATTTCCACAGGAAAATACTCACCCTCCCAGA

GATGATGAGGATGTTCTCAGAAAACTTGGCGCATCATCTGGAAATAGATTCAGGGGTCAT

CACTCTGGACCCTCAGACCGCCAGCCGGAGCCTGGTTCTCTCGGAAGACAGGAAGTCAGT

GAGGTACACCCGGCAGAAGAAGAGCCTGCCAGACAGCCCCCTGCGCTTCGACGGCCTCCC

GGCGGTTCTGGGCTTCCCGGGCTTCTCCTCCGGGCGCCACCGCTGGCAGGTTGACCTGCA

GCTGGGCGACGGCGGCGGCTGCACGGTGGGGGTGGCCGGGGAGGGGGTGAGGAGGAAGGG

AGAGATGGGACTCAGCGCCGAGGACGGCGTCTGGGCCGTGATCATCTCGCACCAGCAGTG

CTGGGCCAGCACCTCCCCGGGCACCGACCTGCCGCTGAGCGAGATCCCGCGCGGCGTGAG

AGTCGCCCTGGACTACGAGGCGGGGCAGGTGACCCTCCACAACGCCCAGACCCAGGAGCC

CATCTTCACCTTCACTGCCTCTTTCTCCGGCAAAGTCTTCCCTTTCTTTGCCGTCTGGAA

AAAAGGTTCCTGCCTTACGCTGAAAGGCTGAAGTGGGGCGCGCGAAGGGCGGCGAAGCGG

AGACGGCGGCTCTCCGGGATCCAGCTCCGCCCCTGGCCAGTGTGCGGCCCGGGGGCTCCC

TGTGCCCGCGTGAGGCGAGAGAACAGGGGACTTGAGTCTCGAACAGCGGTTGTTTTTACT

TTATTTATCTTAGGCCCTCAGCTCCCTGACGTCCTGAGCCTCCCTGTGACGCTCTGGCCT

TCTCTGCACCTCAGAGTGCAGAACCACAGACGGCTTCGGCTGTGCCTAGGGCAACAGCCA

ACCTAGGAGCCAGCGGGCTTTCGGGGAAAAAAAAGAAAAAGACATCTAAAATAAAATGTT

TAAACTGTTTCAAAATAAAAAAAAAAAAAAAAAAA

>AV656862
TTTATACATTCTAAATCTCCCCAGTTTCTTTGGGGCTGGAAGATGCAACTTCCATTTAAT

AGAAACTTTGAAATCTTGGGGTAAGGGAGCAGTGGGGGGACTAGGGAGAAGGATAAGAAA

TAGAATTATTGAAAAGCCCCCACCAGGGACCTTCCTGGCCAGAATATGCAGAGTAATTCC

TGCTGGCTTCACCTTTGAAAGTCCCTCGAAACTATGCAGATGAAACTGAGTCTGTTTTTG

ATATTGTCAGATGTATTCTACCTTGGAAGTCCCAACACCTAAACTGGAATTCTTGTATTT

ACATCTCCTCCACTGTCCCCCACACCACCCCTCAATTCCTGCTGCCCCTGCTAATGTTAA

GCATTTTTCTCTTGTTATCATCAGGTTCACATTAAAAACAGATACTTACAAACTGACTTG

AAGCACAGATACTTTTACGAATGTGATAAAATATTTTCTTAAGAAAAGGAAAGAGGATGT

GGGTCAAATAAAACACCGCATGGATGTTGATTGGTGAATACTGGTGTAAGAAAAGGGAGC

TCAGGAATTTTTATTACTGTATTTGTAAATGAGTTTGAAGGAATTTGTAAATGCCACTGG

TACATTTTTAAGGTGACACATTTGCTCCTTATAAAGTTATTAAAAATTACAGGGTAAGCT

TAAATGACGTTTGCCAGTAGTTTTACTTTATATAATCAATATTGATATTGTTGCTGAACT

ATGTAACTTTATGATGCATTTTTCAGTCCCTTTTCAGAGCAAATGCTTTTGCAATGGTAG

TAATGTTTAGTTTAAATTGACTTAATAAATTATTACCTGAGCAAAAAAAAAAAAAAAAAA

AAAAAAAAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAATAATAAAAAAAAAAAAAACA

AACAAATCAATAAAACTTAAACAAAAAAAAAATAAAAAAAAA

>AI499593
GCAGAGATCGCCACATCGTCGGACAAGGTCAAGGACGGGGGCGGCGGGAACGAGGGCTCT

CCATGCCCACCGTGTCCCGGGCCCATAGCCGGGCAAGCCCTAGGAGGCAGCCGGGCGTCG

CCGGCCCCGGCGCCGTCACGCTCGCCCTCGGCGCAGTGTCCTTTTCCAGGCGGGACGGTG

CTGTCCCGGCCTCTCTACTACACCGCGCCCTTCTATCCCGGCTACACGAACTATGGCTCC

TTCGGACACCTTCATGGCCACCCGGGGCCGGGGCCGGGCCCCACACCCGGTCCGGGGTCT

CATTTCAATGGATTAAACCAGACCGTGTTGAACCGAGCGGACGCTTTGGCTAAAGACCCG

AAAATGTTGCGGAGCCAGTCTCAGCTAGACCTGTGCAAAGACTCTCCCTATGAATTGAAG

AAAGGTATGTCCGACATTTAACGCGGGCTGCGTCGGTCCCGGACTTTTCTAATTTATTAA

AAACATGGCCTTGGCAGTTATTTTTCCATCACCGAGAGAGAGAGACAGAGAGAGAAAATA

AACTACCCCTCCTATTCAGAAGTTTATAGTTTATGGAGATGGATGACATAAAAATGTAAA

CATCTCCACACACACAAAAAAATGTCTTAACCAACCGAAAAGAAAAATTAAAAAAGGATT

TGTATTAAATCTTATTCTGTATATTTAATGTAGCATTTTTGTATTTAAATTGATAATTCA

ATATCTTTGAAGTAAATTATGAAATCAAGACACCTGTACAGGCATTTAATGTTTTTTTGT

AATATAAATATATACATTTGTGTTTCCCCCAAAACTGTTTCATAGTTAAAAAATACAAGT

TTAATTTAATTTTTTACACCTATTGATTCTGCTGGGTATGAGCTAAAGTATTACGGAAAG

GAAACAGGTTATACTCTTAGATTTAAAAAGTGAAAGAAACTGCAGGCGCCTTTGTAAAAT

GCAAAATATTTAATTAAAAGAGATTTTAACATAATGAGAGCCACTCATTACTTTTTAGAA

GCCTCAATAAACTGTCCATTGCCTTGGTCAAAAAAAAAAAAAAAAAAAAA

>AI952953
ATATCCAAGAAATTTGGACACCTATACCTACAGAATAATGAAATAGAAAAGATGAATCTN

ACAGTGATGTGTCCTTCTATTGACCCACTACATTACCACCATTTAACATACATTCGTGTG

GACCAAAATAAACTAAAAGAACCAATAAGCTCATACATCTTCTTCTGCTTCCCTCATATA

CACACTATTTATTATGGTGAACAACGAAGCACTAATGGTCAAACAATACAACTAAAGACC

CAAGTTTTCAGGAGATTTCCAGATGATGATGATGAAAGTGAAGATCACGATGATCCTGAC

AATGCTCATGAGAGCCCAGAACAAGAAGGAGCAGAAGGGCACTTTGACCTTCATTATTAT

GAAAATCAAGAATAGCAAGAAACTATATAGGTATACACTTACGACTTCACAAAACCTATA

CTTAATATAGTAAATCTAAGTAAACATGTATTACTCAAAGTAATATATTTAGAATTATGT

ATTAGTATAAGATCAGAATTGAATTTAAGTTGTTGGTGACATCTGCATCATTTCATAGGA

TTAGAACTTACTCAAAATAATGTAAATCTTTAAAAATATAAATTAGAATGACAAGTGGGA

ATCATAAATTAAACGTTAATGGTTTCTTATGCTCTTTTTAAATATAGAAATATCATGTTA

AAAAAAAA

>AK025470
ATGATTGCAACAGTGGATTTAAAAGTCAATGAATATGAGAAAAACCAAAAATGGCTTGAG

ATCCTAAATAAGATTGAAAACAAAACATACACGAAGCTCAAAAATGGACATGTGTTTAGG

AAGCAGGCACTGATGAGTGAAGAAAGGACTCTGTTATATGATGGCCTTGTTTACTGGAAA

ACTGCTACAGGTCGTTTCAAAGATATCCTAGCTCTACTTCTAACTGATGTGCTGCTCTTT

TTACAAGAAAAAGACCAGAAATACATCTTTGCAGCCGTTGATCAGAAGCCATCAGTTATT

TCCCTTCAAAAGCTTATTGCTAGAGAAGTTGCTAATGAGGAGAGAGGAATGTTTCTGATC

AGTGCTTCATCTGCTGGTCCTGAGATGTATGAAATTCACACCAATTCCAAGGAGGAACGC

AATAACTGGATGAGACGGATCCAGCAGGCTGTAGAAAGTTGTCCTGAAGAAAAAGGGGGA

AGGACAAGTGAATCTGATGAAGACAAGAGGAAAGCTGAAGCCAGAGTGGCCAAAATTCAG

CAATGTCAAGAAATACTCACTAACCAAGACCAACAAATTTGTGCGTATTTGGAGGAGAAG

CTGCATATCTATGCTGAACTTGGAGAACTGAGCGGATTTGAGGACGTCCATCTAGAGCCC

CACCTCCTTATTAAACCTGACCCAGGCGAGCCTCCCCAGGCAGCCTCATTACTGGCAGCA

GCACTGAAAGAAGCATTAGTCACAGGAGGGAGAGAAGGAAGAGGCTGTTCGGATGTGGAT

CCCGGGATCCAGGGTGTGGTAACCGACTTGGCCGTCTCTGATGCAGGGGAGAAGGTGGAA

TGTAGAAATTTTCCAGGTTCTTCACAATCAGAGATTATACAAGCCATACAGAATTTAACC

CGTCTCTTATACAGCCTTCAGGCCGCCTTGACCATTCAGGACAGCCACATTGAGATCCAC

AGGCTGGTTCTCCAGCAGCAGGAGGGCCTGTCTCTCGGCCACTCTATCCTCCGAGGCGGC

CCCTTGCAGGACCAGAAGTCTCGCGACGCGGACAGGCAGCATGAGGAGCTGGCCAATGTG

CACCAGCTTCAGCACCAGCTCCAGCAGGGGCAGCGGCGCTGGCTGCGCAGGTGTGAGCAG

CAGCAGCGGGCGCAGGCGACCAGGGAGAGCTGGCTGCAGGAGCGGGAGCGGGAGTGCCAG

TCGCAGGAGGAGCTGCTGCTGCGGAGCCGGGGCGAGCTGGACCTCCAGCTCCAGGAGTAC

CAGCACAGCCTGGAGCGGCTGAGGGAGGGCCAGCGCCTGGTGGAGAGGGAGCAGGCGAGG

ATGCGGGCCCAGCAGAGCCTGCTGGGCCACTGGAAGCACGGCCGGCAGAGGAGCCTGTCC

GCGGTGCTCCTTCCGGGTGGCCCCGAGGTAATGGAACTTAATCGATCTGAGAGTTTATGT

CATGAAAACTCATTCTTCATCAATGAAGCTTTAGTACAAATGTCATTTAACACTTTCAAC

AAACTGAATCCATCAGTTATCCATCAGGATGCCACTTACCCTACAACTCAATCTCATTCT

GACTTGGTGAGGACTAGTGAACATCAAGTAGACCTCAAGGTGGACCCTTCTCAGCCTTCG

AATGTCAGTCACAAACTGTGGACAGCCGCTGGTTCCGGCCATCAGATACTTCCTTTCCAT

GAAAGCAGCAAGGATTCTTGTAAAAATGGCTCCAGTATGACAAAGTGCAGTTGTACGTTG

ACATCTCCCCCGGGACTGTGGACTGGAACCACATCTACTTTGAAGGATTTGGACACCTCC

CACACTGAGTCCCCAACCCCCCATGACTCAAATTCACACCGCCCTCAACTGCAGGCGTTT

ATAACAGAAGCAAAGCTAAATCTACCGACAAGGACAATGACCAGACAAGATGGGGAAACT

GGAGATGGAGCCAAAGAAAATATTGTTTACCTCTAATTGTGTTGTCATTTTTCCAAACAA

AACAAAACACTGGCACTTTTGGGAGAAACTTTTTGTCTCCATTCCTTATGTATGTGTGAT

TGTCTGTGTCCAAATTGCTTTAAGAATAATATTTAATATTTCCTGGAAGCTCATTTTTTT

GGCATGAGTCTAATTAAATTATTGAAAGCCACCCTGTTTGTATAATCTTTAACTTATCAA

ATCTAATTTCAGATTTCTGGAGGAGAAACTAACTTGAATAAGCAGGACTATTTTAAAAGT

TGTTTTGACGCTAGAGTAAAATTCCATGTCACATTTTCTACCCAATCATCTGGATTTCAA

GATTCCTTTTAAGATCTCAATGAAGCAATTTGGATTTAAAGAGTGGTATTCACAAGGGGT

GAACTTTCACAGTCAGGGCAGTTGCCTCAGTGCCCACATAGGCAGAGGAGGATGTGGGAA

AGGGCTTTTCTCAGCTAGTTTTTGTGTGCTCATTTCTTCTGGGAGCATTAAAAGTGGTGA

TCTGTTACAGTCACTATTCAACTGGGCACGTGTTGTGATTGGTCAGTCACTGAGCCAGGG

ATACAGTCCGGACTTGCTTAGTACCTAAGCCTAATGCTGGTGGGGTTTCAAGACATGGTT

CAGCATCATCTTTTAACAAGGCCCAGAGGCCCAGAGCCCGCATCAAGTCATTTTGATGTA

AATAGTGAACTTTGTTAGAGCCCTCACTTCTATCAATCAGCTGTCCTGTCCCTGCCAGCA

CCTGGAGCACCAACTACCACTCCCTGGAAAGAACCCTTCCCTGCAGTTTTTTAAGGACAA

AACTGCCCACTCCTCATTAAGTTTGCTGCCTGGATACACTTTTCCACAAAGGAAAACTGG

CATATCCTGCCTTCCGAGTAGTATGGGTCTCTGTGTGAGAAACCAGGAGATATTTTCATC

TTGTTCGGAAATACTTGTATGTATTTTGGTGTCAATAAATATCTTGTACCTCATTAAAAA

AAAAAAAAAAAAA

>NM_006378
CTGAGCCGCATCTGCAATAGCACACTTGCCCGGCCACCTGCTGCCGTGAGCCTTTGCTGC

TGAAGCCCCTGGGGTCGCCTCTACCTGATGAGGATGTGCACCCCCATTAGGGGGCTGCTC

ATGGCCCTTGCAGTGATGTTTGGGACAGCGATGGCATTTGCACCCATACCCCGGATCACC

TGGGAGCACAGAGAGGTGCACCTGGTGCAGTTTCATGAGCCAGACATCTACAACTACTCA

GCCTTGCTGCTGAGCGAGGACAAGGACACCTTGTACATAGGTGCCCGGGAGGCGGTCTTC

GCTGTGAACGCACTCAACATCTCCGAGAAGCAGCATGAGGTGTATTGGAAGGTCTCAGAA

GACAAAAAAGCAAAATGTGCAGAAAAGGGGAAATCAAAACAGACAGAGTGCCTCAACTAC

ATCCGGGTGCTGCAGCCACTCAGCGCCACTTCCCTTTACGTGTGTGGGACCAACGCATTC

CAGCCGGCCTGTGACCACCTGAACTTAACATCCTTTAAGTTTCTGGGGAAAAATGAAGAT

GGCAAAGGAAGATGTCCCTTTGACCCAGCACACAGCTACACATCCGTCATGGTTGATGGA

GAACTTTATTCGGGGACGTCGTATAATTTTTTGGGAAGTGAACCCATCATCTCCCGAAAT

TCTTCCCACAGTCCTCTGAGGACAGAATATGCAATCCCTTGGCTGAACGAGCCTAGTTTC

GTGTTTGCTGACGTGATCCGAAAAAGCCCAGACAGCCCCGACGGCGAGGATGACAGGGTC

TACTTCTTCTTCACGGAGGTGTCTGTGGAGTATGAGTTTGTGTTCAGGGTGCTGATCCCA

CGGATAGCAAGAGTGTGCAAGGGGGACCAGGGCGGCCTGAGGACCTTGCAGAAGAAATGG

ACCTCCTTCCTGAAAGCCCGACTCATCTGCTCCCGGCCAGACAGCGGCTTGGTCTTCAAT

GTGCTGCGGGATGTCTTCGTGCTCAGGTCCCCGGGCCTGAAGGTGCCTGTGTTCTATGCA

CTCTTCACCCCACAGCTGAACAACGTGGGGCTGTCGGCAGTGTGCGCCTACAACCTGTCC

ACAGCCGAGGAGGTCTTCTCCCACGGGAAGTACATGCAGAGCACCACAGTGGAGCAGTCC

CACACCAAGTGGGTGCGCTATAATGGCCCGGTACCCAAGCCGCGGCCTGGAGCGTGCATC

GACAGCGAGGCACGGGCCGCCAACTACACCAGCTCCTTGAATTTGCCAGACAAGACGCTG

CAGTTCGTTAAAGACCACCCTTTGATGGATGACTCGGTAACCCCAATAGACAACAGGCCC

AGGTTAATCAAGAAAGATGTGAACTACACCCAGATCGTGGTGGACCGGACCCAGGCCCTG

GATGGGACTGTCTATGATGTCATGTTTGTCAGCACAGACCGGGGAGCTCTGCACAAAGCC

ATCAGCCTCGAGCACGCTGTTCACATCATCGAGGAGACCCAGCTCTTCCAGGACTTTGAG

CCAGTCCAGACCCTGCTGCTGTCTTCAAAGAAGGGCAACAGGTTTGTCTATGCTGGCTCT

AACTCGGGCGTGGTCCAGGCCCCGCTGGCCTTCTGTGGGAAGCACGGCACCTGCGAGGAC

TGTGTGCTGGCGCGGGACCCCTACTGCGCCTGGAGCCCGCCCACAGCGACCTGCGTGGCT

CTGCACCAGACCGAGAGCCCCAGCAGGGGTTTGATTCAGGAGATGAGCGGCGATGCTTCT

GTGTGCCCGGATAAAAGTAAAGGAAGTTACCGGCAGCATTTTTTCAAGCACGGTGGCACA

GCGGAACTGAAATGCTCCCAAAAATCCAACCTGGCCCGGGTCTTTTGGAAGTTCCAGAAT

GGCGTGTTGAAGGCCGAGAGCCCCAAGTACGGTCTTATGGGCAGAAAAAACTTGCTCATC

TTCAACTTGTCAGAAGGAGACAGTGGGGTGTACCAGTGCCTGTCAGAGGAGAGGGTTAAG

AACAAAACGGTCTTCCAAGTGGTCGCCAAGCACGTCCTGGAAGTGAAGGTGGTTCCAAAG

CCCGTAGTGGCCCCCACCTTGTCAGTTGTTCAGACAGAAGGTAGTAGGATTGCCACCAAA

GTGTTGGTGGCATCCACCCAAGGGTCTTCTCCCCCAACCCCAGCCGTGCAGGCCACCTCC

TCCGGGGCCATCACCCTTCCTCCCAAGCCTGCGCCCACCGGCACATCCTGCGAACCAAAG

ATCGTCATCAACACGGTCCCCCAGCTCCACTCGGAGAAAACCATGTATCTTAAGTCCAGC

GACAACCGCCTCCTCATGTCCCTCTTCCTCTTCTTCTTTGTTCTCTTCCTCTGCCTCTTT

TTCTACAACTGCTATAAGGGATACCTGCCCAGACAGTGCTTGAAATTCCGCTCGGCCCTA

CTAATTGGGAAGAAGAAGCCCAAGTCAGATTTCTGTGACCGTGAGCAGAGCCTGAAGGAG

ACGTTAGTAGAGCCAGGGAGCTTCTCCCAGCAGAATGGGGAGCACCCCAAGCCAGCCCTG

GACACCGGCTATGAGACCGAGCAAGACACCATCACCAGCAAAGTCCCCACGGATAGGGAG

GACTCACAGAGGATCGACGACCTTTCTGCCAGGGACAAGCCCTTTGACGTCAAGTGTGAG

CTGAAGTTCGCTGACTCAGACGCAGATGGAGACTGAGGCCGGCTGTGCATCCCCGCTGGT

GCCTCGGCTGCGACGTGTCCAGGCGTGGAGAGTTTTGTGTTTCTCCTGTTCAGTATCCGA

GTCTCGTGCAGTGCTGCGTAGGTTAGCCCGCATCGTGCAGACAACCTCAGTCCTCTTGTC

TATTTTCTCTTGGGTTGAGCCTGTGACTTGGTTTCTCTTTGTCCTTTTGGAAAAATGACA

AGCATTGCATCCCAGTCTTGTGTTCCGAAGTCAGTCGGAGTACTTGAAGAAGGCCCACGG

GCGGCACGGAGTTCCTGAGCCCTTTCTGTAGTGGGGGAAAGGTGGCTGGACCTCTGTTGG

CTGAGAAGAGCATCCCTTCAGCTTCCCCTCCCCGTAGCAGCCACTAAAAGATTATTTAAT

TCCAGATTGGAAATGACATTTTAGTTTATCAGATTGGTAACTTATCGCCTGTTGTCCAGA

TTGGCACGAACCTTTTCTTCCACTTAATTATTTTTTTAGGATTTTGCTTTGATTGTGTTT

ATGTCATGGGTCATTTTTTTTTAGTTACAGAAGCAGTTGTGTTAATATTTAGAAGAAGAT

GTATATCTTCCAGATTTTGTTATATATTTGGCATAAAATACGGCTTACGTTGCTTAAGAT

TCTCAGGGATAAACTTCCTTTTGCTAAATGCATTCTTTCTGCTTTTAGAAATGTAGACAT

AAACACTCCCCGGAGCCCACTCACCTTTTTTCTTTTTCTTTTTTTTTTTTTAACTTTATT

CCTTGAGGGAAGCATTGTTTTTGGAGAGATTTTCTTTCTGTACTTCGTTTTACTTTTCTT

TTTTTTTAACTTTTACTCTCTCGAAGAAGAGGACCTTCCCACATCCACGAGGTGGGTTTT

GAGCAAGGGAAGGTAGCCTGGATGAGCTGAGTGGAGCCAGGCTGGCCCAGAGCTGAGATG

GGAGTGCGGTACAATCTGGAGCCCACAGCTGTCGGTCAGAACCTCCTGTGAGACAGATGG

AACCTTCACAAGGGCGCCTTTGGTTCTCTGAACATCTCCTTTCTCTTCTTGCTTCAATTG

CTTACCCACTGCCTGCCCAGACTTTCTATCCAGCCTCACTGAGCTGCCCACTACTGGAAG

GGAACTGGGCCTCGGTGGCCGGGGCCGCGAGCTGTGACCACAGCACCCTCAAGCATACGG

CGCTGTTCCTGCCACTGTCCTGAAGATGTGAATGGGTGGTACGATTTCAACACTGGTTAA

TTTCACACTCCATCTCCCCGCTTTGTAAATACCCATCGGGAAGAGACTTTTTTTCCATGG

TGAAGAGCAATAAACTCTGGATGTTTGTGCGCGTGTGTGGACAGTCTTATCTTCCAGCAT

GATAGGATTTGACCATTTTGGTGTAAACATTTGTGTTTTATAAGATTTACCTTGTTTTTA

TTTTTCTACTTTGAATTGTATACATTTGGAAAGTACCCAAATAAATGAGAAGCTTCTATC

CTTAAAAAAAAAAAAAA

>AA993639
CCCNTCCCCAGAGGCAGGAAAANCAGTNTGCCGAAAGGATAGACTGNGGTGCNGTCTTTC

CCCAAGTTNTGAACTAGTTTTAAGGTAGCTTAGGATGAAAAATGGAGAATGATTGGGGGT

TCCAAACCACTTTCTTCTCCCTTGGCTTATATCTCTTCACCATTTGGTGGTCAACTGTGG

GCCTACCCTGGACCTCATCTACTCAGCGAGAATTGGACATGAAGCTAGAGGCAGCTGCCT

TGGAAGGGAAGTCAGGCTCACTTGGACAGCCCAGGCCATGGCAGGAAGAATCCCTTCCTC

TTGGGGTCCTTGATGGGCATGTGTGATGGGGAAGGAGCAGTCTCCCAGCCCTGGGTCTGC

TCCCCACATCTCTCCTAATTCCACTTCACCTTTTGCCACCCCCTCCCCACCAGAGGCCTA

GCCCTTTTGTCACCGAAGGCCCCCAGAGTGTTTCTGTGTGAAACCCTCTCATTTACACTG

TGGCATCAAAATCCACAAAAGATGGATTAATTGCACTCTGGTTAATAGCAGCAGCACAAT

GATTAAAATCTATATTCCTATCTTCTCTAGCACCCTGGTGTGGGGATGGGGCGGAAGGGT

GTCTTGAGGGGCAGGGAGGACCCCATAAAACAATCCCTCCTGCATTCTCAGGCTAAATAG

GGCCCCCAGTGACTACCTGTTCTTGGCTGTCCCCTCTGAAGAGCTCTGCCTTCTCACAGC

CACCACCAGTTGCCCCACTCCCAGGAAAACAGCACATGTTCTTCTTCTCCTGCCTTGAGA

CTGCGTGTTAGTCTTCCATTCATAACTCATCAGCAGCTCAGTCCTTCTTATGTCTAGTCT

CAGTTCATTCAGCCAAAGCTCATTTTTGTCCTATCCAAAGTAGAAAGGGTTCTTTTAGAA

AACTTGAAGAATGTGCCTCCTCTTAGCATCTGTTTCTGACTCCCAGTTATTTTTAAAATA

AATGATGAATAAAATGCCTGCCCTGAAGGGTTCTGGAGGAGTCAGGTATCAAAAAAAAAA

AAA

>BE552004
TTTTTAAGATGATCTTGCTCCGTCACCCAGGCTGGAGTGCAGTGGCGTAATCATGGCTTC

CTGCAGCCTCAAACTCCTGGGCTCAATGAGTTCCTTGAGATCTTCCATCCTCAGCTTCCC

AAGTAGCTAGTAGTAGTAGTGGCTTGCACCAACGCTCCTGCCCTAATTTTCAATATTTTT

TTTGTAGAGATAGGATCTCACTGTGTTACCCAAGCTAGACTTGAACTCCTGGCCTCAAGC

GATCCTTCCGCCTTGGCCTCCCAAAGTGTTGGGATTACAGGCATTAGCTACCACACCTGG

CCAAGGCCCAGGTTTCGACAGAAAGGGAGAGAAAACCTGCCAGAGATGCCATTTCGGAGC

CACTCTGCTTGGCAGGGACCTGTGTTCCCCTCATGCAGGTTCATCCTTAGAGGGCTGCGG

TCTTATCTGGTTGTGCAAAAGTCCCACAACCTTTCTGGATTGATAGTTTGTGGTGAAATA

AACAATTTTAGTTTGTTTGGAGAATCTTTTGTATACAAAATACAAATAAAACCTAAATCA

AAGAAACAGA

>BC010437
GAGGGGCCGGAGGCGTCCCCGCTCCCGCTCGCTACTAGCCCGCGGGCCAGCGCCGCGTCC

CGAGCCCCGGCGGGAGCCATGGCTCTAAAAGGACAAGAAGATTATATTTATCTTTTCAAG

GATTCAACACATCCAGTGGATTTTCTGGATGCATTCAGAACATTTTACTTGGATGGATTA

TTTACTGATATTACTCTTCAGTGTCCTTCAGGCATAATTTTCCATTGTCACCGAGCCGTT

TTAGCTGCTTGCAGCAATTATTTTAAGGCAATGTTCACAGCTGACATGAAAGAAAAATTT

AAAAATAAAATAAAACTCTCTGGCATCCACCATGATATTCTGGAAGGCCTTGTAAATTAT

GCATACACTTCCCAAATTGAAATAACTAAAAGAAATGTTCAAAGCCTGCTTGAGGCAGCG

GATCTGCTACAGTTCCTTTCAGTAAAGAAGGCTTGTGAGCGGTTTTTGGTAAGGCACTTG

GATATTGATAATTGTATTGGAATGCACTCCTTTGCAGAATTTCATGTGTGTCCAGAACTA

GAGAAGGAATCTCGAAGAATTCTATGTTCAAAGTTTAAGGAAGTGTGGCAACAAGAAGAA

TTTCTGGAAATCAGCCTTGAAAAGTTTCTCTTTATCTTGTCCAGAAAGAATCTCAGTGTT

TGGAAAGAAGAAGCTATCATAGAGCCAGTTATTAAGTGGACTGCTCATGATGTAGAAAAT

CGAATTGAATGCCTCTATAATCTACTGAGCTATATCAACATTGATATAGATCCAGTGTAC

TTAAAAACAGCCTTAGGCCTTCAAAGAAGCTGCCTGCTCACCGAAAATAAGATCCGCTCC

CTAATATACAATGCCTTGAATCCCATGCATAAAGAGATTTCCCAGAGGTCCACAGCCACA

ATGTATATAATTGGAGGCTATTACTGGCATCCTTTATCAGAGGTTCACATATGGGATCCT

TTGACAAATGTTTGGATTCAGGGAGCAGAAATACCAGATTATACCAGGGAGAGCTATGGT

GTTACATGTTTAGGACCCAACATTTATGTAACTGGGGGCTACAGGACGGATAACATAGAA

GCTCTTGACACAGTGTGGATCTATAACAGTGAAAGTGATGAATGGACAGAAGGTTTGCCA

ATGCTCAATGCCAGGTATTACCACTGTGCAGTCACCTTGGGTGGCTGTGTCTATGCTTTA

GGTGGTTACAGAAAAGGGGCTCCAGCAGAAGAGGCTGAGTTCTATGATCCTTTAAAAGAG

AAATGGATTCCTATTGCAAACATGATTAAAGGTGTGGGAAATGCTACTGCCTGTGTCTTA

CATGATGTTATCTACGTCATTGGTGGCCACTGTGGCTACAGAGGAAGCTGCACCTATGAC

AAAGTTCAGAGCTACAATTCCGATATCAACGAATGGAGCCTCATCACCTCCAGTCCACAT

CCAGAATATGGATTGTGCTCAGTTCCGTTTGAAAATAAGCTCTATCTAGTCGGTGGACAA

ACTACAATCACAGAATGCTATGACCCTGAACAAAATGAATGGAGAGAGATAGCTCCCATG

ATGGAAAGGAGGATGGAGTGCGGTGCCGTGATCATGAATGGATGTATTTATGTCACTGGA

GGATACTCCTACTCAAAGGGAACGTATCTTCAGAGCATTGAGAAATATGATCCAGATCTT

AATAAGTGGGAAATAGTGGGTAATCTTCCCAGTGCCATGCGGTCTCATGGGTGTGTTTGT

GTGTATAATGTCTAATTGAATCTGCAGAAATGACCAAGCAATCACTTTTTTGGAGTATAG

TTTTATAAAAAAAGAATGCAGGGTTTGAAGTTCCTTACCTGATAATTGTGTCTGGCACAT

GATAGGGGATCAGTAAATTGTAATTCCTAACCCTACTGTACTCCCAAACATGGTGATTCA

TGGTCAAGAAAAATCTTATATATATATATACACACACATATATATGTGTTCATATATATG

TATACATATATGTGTATATATACGCATGTATGTATACATATATGTGTATATATACGCATG

TATGTATGCATATGTGTGTATATATACGTATGTATGTATACATATGTGTATATATACGTA

TGTATGTATACATATATGTGTATATATGCGTATGTATGTATACATATATGTGTATATATA

CGTATGTATGTATACATATATGTGTATATATACGTATGTATGTATACATATATGTGTATA

TATACGTATGTATGTATACATATATGTGTGTATATACGTGTGTATGTATACATATATGTG

TATATATACGTGTGTATGTATACATATATGTGTATATATGCGTGTGTATGTATACATATA

TGTGTATATATACGTGTGTATGTATACATATATGTGTATATATACGTGTGTATGTATACA

TATATGTGTATATATGCGTGTGTATATATATACACATATATACGTATATATGTATATATA

TATACACAGTTGAATCAGTGGGATTAATACCTATAATCTCTGGTTTTCAAAGGTAATATG

GAATATTTGACACTTGGTAAAAGGTGAACTACCTTTGTAGTGAATCTTTTCCTCTTGGTA

GCATCAACACTGGGGATAAATCAGAACCATTCTGTGGAATGAAATGTTTCTCAAGAGCCT

ATAATATAGTAGATAGTGCATATTAAGATGTCTGGCTGGGCATGGTGGCTCATGCCTGTA

ATCCCAGCACTTTGGGAGGCTGAGGCGGGAGGATCACTTGAGCCTAGAAGTTGGAGACTA

ACCTGGCGAGACCCTGTCTCAAAAAAAAAAAAAAAAAA

>R15881
ACCCTTTTGTGACCAGCTGCATACCCCAAAACCTTTTGGAATCTGGGCTAACTGGCTGTG

CCTACATCAACAGCACCCGTGAACCCCCGTGTGCTATGCTCTGTGCAACAAAACATTCAG

AACCCACTTTCAAGATGCTGCTGCTGTGCCAGTGTGACAAAAAAAAGAGGCGCAAGCAGC

AGTACCAGCAGAGACAGTCGGTCATTTTTCACAAGCGCGCACCCGAGCAGGCCTTGTAGA

ATGAGGTTGTATCAATAGCAGTGACAAAACGCACACATCAACCCACAGACCTTAGGAGGA

GGAAGGCGAGGGCGGGGTGACTTCTGGTGATGATAAAAATGGTTTTATCACCCAGATGTG

AAAGAAGCTGCCTGTTTACTGATCCATTGAATAAACCCATTTTAATAGAAAAAGTCAATA

CCAATTCAGCAAAAAAAAA

>AF191770
TATCTATGTAACAAATCGCAGCACAGGAGTCCCCTGGGCTCCCTCAGGCTCTGGTATGAC

ATATTTGAGCCATATAAATTCAGCTTCTCCTCTGGCATCTGTTAGCCGACTCACTTGCAA

CTCCACCTCAGCAGTGGTCTCTCAGTCCTCTCAAAGCAAGGAAAGAGTACTGTGTGCTGA

GAGACCATGGCAAAGAATCCTCCAGAGAATTGTGAAGACTGTCACATTCTAAATGCAGAA

GCTTTTAAATCCAAGAAAATATGTAAATCACTTAAGATTTGTGGACTGGTGTTTGGTATC

CTGACCCTAACTCTAATTGTCCTGTTTTGGGGGAGCAAGCACTTCTGGCCGGAGGTACCC

AAAAAAGCCTATGACATGGAGCACACTTTCTACAGCAGTGGAGAGAAGAAGAAGATTTAC

ATGGAAATTGATCCTGTGACCAGAACTGAAATATTCAGAAGCGGAAATGGCACTGATGAA

ACATTGGAAGTACACGACTTTAAAAACGGATACACTGGCATCTACTTCGTGGGTCTTCAA

AAATGTTTTATCAAAACTCAGATTAAAGTGATTCCTGAATTTTCTGAACCAGAAGAGGAA

ATAGATGAGAATGAAGAAATTACCACAACTTTCTTTGAACAGTCAGTGATTTGGGTCCCA

GCAGAAAAGCCTATTGAAAACCGAGATTTTCTTAAAAATTCCAAAATTCTGGAGATTTGT

GATAACGTGACCATGTATTGGATCAATCCCACTCTAATATCAGTTTCTGAGTTACAAGAC

TTTGAGGAGGAGGGAGAAGATCTTCACTTTCCTGCCAACGAAAAAAAAGGGATTGAACAA

AATGAACAGTGGGTGGTCCCTCAAGTGAAAGTAGAGAAGACCCGTCACGCCAGACAAGCA

AGTGAGGAAGAACTTCCAATAAATGACTATACTGAAAATGGAATAGAATTTGATCCCATG

CTGGATGAGAGAGGTTATTGTTGTATTTACTGCCGTCGAGGCAACCGCTATTGCCGCCGC

GTCTGTGAACCTTTACTAGGCTACTACCCATATCCATACTGCTACCAAGGAGGACGAGTC

ATCTGTCGTGTCATCATGCCTTGTAACTGGTGGGTGGCCCGCATGCTGGGGAGGGTCTAA

TAGGAGGTTTGAGCTCAAATGCTTAAACTGCTGGCAACATATAATAAATGCATGCTATTC

AATGAATTTCTGCCTATGAGGCATCTGGCCCCTGGTAGCCAGCTCTCCAGAATTACTTGT

AGGTAATTCCTCTCTTCATGTTCTAATAAACTTCTACATTATCAAAAAA

>BC005364
GCGGATCGCTGCTCCCTCTCGCCATGGCGCAGGTGCTGATCGTGGGCGCCGGGATGACAG

GAAGCTTGTGCGCTGCGCTGCTGAGGAGGCAGACGTCCGGTCCCTTGTACCTTGCTGTGT

GGGACAAGGCTGACGACTCAGGGGGAAGAATGACTACAGCCTGCAGTCCTCATAATCCTC

AGTGCACAGCTGACTTGGGTGCTCAGTACATCACCTGCACTCCTCATTATGCCAAAAAAC

ACCAACGTTTTTATGATGAACTGTTAGCCTATGGCGTTTTGAGGCCTCTAAGCTCGCCTA

TTGAAGGAATGGTGATGAAAGAAGGAGACTGTAACTTTGTGGCACCTCAAGGAATTTCTT

CAATTATTAAGCATTACTTGAAAGAATCAGGTGCAGAAGTCTACTTCAGACATCGTGTGA

CACAGATCAACCTAAGAGATGACAAATGGGAAGTATCCAAACAAACAGGCTCCCCTGAGC

AGTTTGATCTTATTGTTCTCACAATGCCAGTTCCTGAGATTCTGCAGCTTCAAGGTGACA

TCACCACCTTAATTAGTGAATGCCAAAGGCAGCAACTGGAGGCTGTGAGCTACTCCTCTC

GATATGCTCTGGGCCTCTTTTATGAAGCTGGTACGAAGATTGATGTCCCTTGGGCTGGGC

AGTACATCACCAGTAATCCCTGCATACGCTTCGTCTCCATTGATAATAAGAAGCGCAATA

TAGAGTCATCAGAAATTGGGCCTTCCCTCGTGATTCACACCACTGTCCCATTTGGAGTTA

CATACTTGGAACACAGCATTGAGGATGTGCAAGAGTTAGTCTTCCAGCAGCTGGAAAACA

TTTTGCCGGGTTTGCCTCAGCCAATTGCTACCAAATGCCAAAAATGGAGACATTCACAGG

TTACAAATGCTGCTGCCAACTGTCCTGGCCAAATGACTCTGCATCACAAACCTTTCCTTG

CATGTGGAGGGGATGGATTTACTCAGTCCAACTTTGATGGCTGCATCACTTCTGCCCTAT

GTGTTCTGGAAGCTTTAAAGAATTATATTTAGTGCCTATATCCTTATTCTCTATATGTGT

ATTGGGTTTTTATTTTCACAATTTTCTGTTATTGATTATTTTGTTTTCTATTTTGCTAAG

AAAAATTACTGGAAAATTGTTCTTCACTTATTATCATTTTTCATGTGGAGTATAAAATCA

ATTTTGTAATTTTGATAGTTACAACCCATGCTAGAATGGAAATTCCTCACACCTTGCACC

TTCCCTACTTTTCTGAATTGCTATGACTACTCCTTGTTGGAGGAAAAGTGGTACTTAAAA

AATAACAAACGACTCTCTCAAAAAAATTACATTAAATCACAATAACAGTTTGTATGCCAA

AAACTTGATTATCCTTATGAAAATTTCAATTCTGAATAAAGAATAATCACATTATCAAAG

CCCCATCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>NM_001337
ACTCGTCTCTGGTAAAGTCTGAGCAGGACAGGGTGGCTGACTGGCAGATCCAGAGGTTCC

CTTGGCAGTCCACGCCAGGCCTTCACCATGGATCAGTTCCCTGAATCAGTGACAGAAAAC

TTTGAGTACGATGATTTGGCTGAGGCCTGTTATATTGGGGACATCGTGGTCTTTGGGACT

GTGTTCCTGTCCATATTCTACTCCGTCATCTTTGCCATTGGCCTGGTGGGAAATTTGTTG

GTAGTGTTTGCCCTCACCAACAGCAAGAAGCCCAAGAGTGTCACCGACATTTACCTCCTG

AACCTGGCCTTGTCTGATCTGCTGTTTGTAGCCACTTTGCCCTTCTGGACTCACTATTTG

ATAAATGAAAAGGGCCTCCACAATGCCATGTGCAAATTCACTACCGCCTTCTTCTTCATC

GGCTTTTTTGGAAGCATATTCTTCATCACCGTCATCAGCATTGATAGGTACCTGGCCATC

GTCCTGGCCGCCAACTCCATGAACAACCGGACCGTGCAGCATGGCGTCACCATCAGCCTA

GGCGTCTGGGCAGCAGCCATTTTGGTGGCAGCACCCCAGTTCATGTTCACAAAGCAGAAA

GAAAATGAATGCCTTGGTGACTACCCCGAGGTCCTCCAGGAAATCTGGCCCGTGCTCCGC

AATGTGGAAACAAATTTTCTTGGCTTCCTACTCCCCCTGCTCATTATGAGTTATTGCTAC

TTCAGAATCATCCAGACGCTGTTTTCCTGCAAGAACCACAAGAAAGCCAAAGCCATTAAA

CTGATCCTTCTGGTGGTCATCGTGTTTTTCCTCTTCTGGACACCCTACAACGTTATGATT

TTCCTGGAGACGCTTAAGCTCTATGACTTCTTTCCCAGTTGTGACATGAGGAAGGATCTG

AGGCTGGCCCTCAGTGTGACTGAGACGGTTGCATTTAGCCATTGTTGCCTGAATCCTCTC

ATCTATGCATTTGCTGGGGAGAAGTTCAGAAGATACCTTTACCACCTGTATGGGAAATGC

CTGGCTGTCCTGTGTGGGCGCTCAGTCCACGTTGATTTCTCCTCATCTGAATCACAAAGG

AGCAGGCATGGAAGTGTTCTGAGCAGCAATTTTACTTACCACACGAGTGATGGAGATGCA

TTGCTCCTTCTCTGAAGGGAATCCCAAAGCCTTGTGTCTACAGAGAACCTGGAGTTCCTG

AACCTGATGCTGACTAGTGAGGAAAGATTTTTGTTGTTATTTCTTACAGGCACAAAATGA

TGGACCCAATGCACACAAAACAACCCTAGAGTGTTGTTGAGAATTGTGCTCAAAATTTGA

AGAATGAACAAATTGAACTCTTTGAATGACAAAGAGTAGACATTTCTCTTACTGCAAATG

TCATCAGAACTTTTTGGTTTGCAGATGACAAAAATTCAACTCAGACTAGTTTAGTTAAAT

GAGGGTGGTGAATATTGTTCATATTGTGGCACAAGCAAAAGGGTGTCTGAGCCCTCAAAG

TGAGGGGAAACCAGGGCCTGAGCCAAGCTAGAATTCCCTCTCTCTGACTCTCAAATCTTT

TAGTCATTATAGATCCCCCAGACTTTACATGACACAGCTTTATCACCAGAGAGGGACTGA

CACCCATGTTTCTCTGGCCCCAAGGGAAAATTCCCAGGGAAGTGCTCTGATAGGCCAAGT

TTGTATCAGGTGCCCATCCCTGGAAGGTGCTGTTATCCATGGGGAAGGGATATATAAGAT

GGAAGCTTCCAGTCCAATCTCATGGAGAAGCAGAAATACATATTTCCAAGAAGTTGGATG

GGTGGGTACTATTCTGATTACACAAAACAAATGCCACACATCACCCTTACCATGTGCCTG

ATCCAGCCTCTCCCCTGATTACACCAGCCTCGTCTTCATTAAGCCCTCTTCCATCATGTC

CCCAAACCTGCAAGGGCTCCCCACTGCCTACTGCATCGAGTCAAAACTCAAATGCTTGGC

TTCTCATACGTCCACCATGGGGTCCTACCAATAGATTCCCCATTGCCTCCTCCTTCCCAA

AGGACTCCACCCATCCTATCAGCCTGTCTCTTCCATATGACCTCATGCATCTCCACCTGC

TCCCAGGCCAGTAAGGGAAATAGAAAAACCCTGCCCCCAAATAAGAAGGGATGGATTCCA

ACCCCAACTCCAGTAGCTTGGGACAAATCAAGCTTCAGTTTCCTGGTCTGTAGAAGAGGG

ATAAGGTACCTTTCACATAGAGATCATCCTTTCCAGCATGAGGAACTAGCCACCAACTCT

TGCAGGTCTCAACCCTTTTGTCTGCCTCTTAGACTTCTGCTTTCCACACCTGCACTGCTG

TGCTGTGCCCAAGTTGTGGTGCTGACAAAGCTTGGAAGAGCCTGCAGGTGCCTTGGCCGC

GTGCATAGCCCAGACACAGAAGAGGCTGGTTCTTACGATGGCACCCAGTGAGCACTCCCA

AGTCTACAGAGTGATAGCCTTCCGTAACCCAACTCTCCTGGACTGCCTTGAATATCCCCT

CCCAGTCACCTTGTGCAAGCCCCTGCCCATCTGGGAAAATACCCCATCATTCATGCTACT

GCCAACCTGGGGAGCCAGGGCTATGGGAGCAGCTTTTTTTTCCCCCCTAGAAACGTTTGG

AACAATGTAAAACTTTAAAGCTCGAAAACAATTGTAATAATGCTAAAGAAAAAGTCATCC

AATCTAACCACATCAATATTGTCATTCCTGTATTCACCCGTCCAGACCTTGTTCACACTC

TCACATGTTTAGAGTTGCAATCGTAATGTACAGATGGTTTTATAATCTGATTTGTTTTCC

TCTTAACGTTAGACCACAAATAGTGCTCGCTTTCTATGTAGTTTGGTAATTATCATTTTA

GAAGACTCTACCAGACTGTGTATTCATTGAAGTCAGATGTGGTAACTGTTAAATTGCTGT

GTATCTGATAGCTCTTTGGCAGTCTATATGTTTGTATAATGAATGAGAGAATAAGTCATG

TTCCTTCAAGATCATGTACCCCAATTTACTTGCCATTACTCAATTGATAAACATTTAACT

TGTTTCCAATGTTTAGCAAATACATATTTTATAGAACTTC

>AI041545
TGAACATATTCAGGCTGATTGGGGACGTGTCCCACCTGGCGGCCATCGTCATCTTGATGG

TAGAGATCTGGAAGACGCGCTCCTGCGCCGGTATTTCTGGGAAAAGCCAGCTTCTGTCTG

CACTGGTCTTCACAACTCGTGACCTGGATCTTTTCACTTCATTTATTTCAGTGTATCACA

CATCTATCAAGGTTATCTACGTTGCCTGCTCGTATGCCACAGTGTACCTGATCTACCTTA

AATTTAAGGCAACATCGGATGGAAATCATGATACCTTCCGAGTGGAGTTTCTGGTGGTCC

CTGTGGGAGGCCTCCTCATTTTTAGTTAATCACGATTTCTCTCCTCTTGAGTACTCAAGG

GAAAGAAGCTCAGTTTGCCAGCATAAGTGCCAAAGACCATCGCCAGCATCTGTCCTTCAG

GGTGTTCGGACAGAATTCTTACCACAGCAAAGGCATAAGATGCTTGATACGGAAAATCAA

GAACTTAACTTTTTTGTTGCAGATAGTCATCAGTGGTTCTGTAAAAACGCAGAGGAAAAG

AGCCAGAAGGTTTCTGTTTAATGCATCTTGCCTTATCTTTTTTTATTACTGTGCACAAAG

ATTTTTTTACACAAACATCCTTAATGCTGTTTTAATAAATTCAGTGTGTAGCTTCAAAAA

AA

>NM_024423
GGCAGGTCTCGCTCTCGGCACCCTCCCGGCGCCCGCGTTCTCCTGGCCCTGCCCGGCATC

CCGATGGCCGCCGCTGGGCCCCGGCGCTCCGTGCGCGGAGCCGTCTGCCTGCATCTGCTG

CTGACCCTCGTGATCTTCAGTCGTGATGGTGAAGCCTGCAAAAAGGTGATACTTAATGTA

CCTTCTAAACTAGAGGCAGACAAAATAATTGGCAGAGTTAATTTGGAAGAGTGCTTCAGG

TCTGCAGACCTCATCCGGTCAAGTGATCCTGATTTCAGAGTTCTAAATGATGGGTCAGTG

TACACAGCCAGGGCTGTTGCGCTGTCTGATAAGAAAAGATCATTTACCATATGGCTTTCT

GACAAAAGGAAACAGACACAGAAAGAGGTTACTGTGCTGCTAGAACATCAGAAGAAGGTA

TCGAAGACAAGACACACTAGAGAAACTGTTCTCAGGCGTGCCAAGAGGAGATGGGCACCT

ATTCCTTGCTCTATGCAAGAGAATTCCTTGGGCCCTTTCCCATTGTTTCTTCAACAAGTT

GAATCTGATGCAGCACAGAACTATACTGTCTTCTACTCAATAAGTGGACGTGGAGTTGAT

AAAGAACCTTTAAATTTGTTTTATATAGAAAGAGACACTGGAAATCTATTTTGCACTCGG

CCTGTGGATCGTGAAGAATATGATGTTTTTGATTTGATTGCTTATGCGTCAACTGCAGAT

GGATATTCAGCAGATCTGCCCCTCCCACTACCCATCAGGGTAGAGGATGAAAATGACAAC

CACCCTGTTTTCACAGAAGCAATTTATAATTTTGAAGTTTTGGAAAGTAGTAGACCTGGT

ACTACAGTGGGGGTGGTTTGTGCCACAGACAGAGATGAACCGGACACAATGCATACGCGC

CTGAAATACAGCATTTTGCAGCAGACACCAAGGTCACCTGGGCTCTTTTCTGTGCATCCC

AGCACAGGCGTAATCACCACAGTCTCTCATTATTTGGACAGAGAGGTTGTAGACAAGTAC

TCATTGATAATGAAAGTACAAGACATGGATGGCCAGTTTTTTGGATTGATAGGCACATCA

ACTTGTATCATAACAGTAACAGATTCAAATGATAATGCACCCACTTTCAGACAAAATGCT

TATGAAGCATTTGTAGAGGAAAATGCATTCAATGTGGAAATCTTACGAATACCTATAGAA

GATAAGGATTTAATTAACACTGCCAATTGGAGAGTCAATTTTACCATTTTAAAGGGAAAT

GAAAATGGACATTTCAAAATCAGCACAGACAAAGAAACTAATGAAGGTGTTCTTTCTGTT

GTAAAGCCACTGAATTATGAAGAAAACCGTCAAGTGAACCTGGAAATTGGAGTAAACAAT

GAAGCGCCATTTGCTAGAGATATTCCCAGAGTGACAGCCTTGAACAGAGCCTTGGTTACA

GTTCATGTGAGGGATCTGGATGAGGGGCCTGAATGCACTCCTGCAGCCCAATATGTGCGG

ATTAAAGAAAACTTAGCAGTGGGGTCAAAGATCAACGGCTATAAGGCATATGACCCCGAA

AATAGAAATGGCAATGGTTTAAGGTACAAAAAATTGCATGATCCTAAAGGTTGGATCACC

ATTGATGAAATTTCAGGGTCAATCATAACTTCCAAAATCCTGGATAGGGAGGTTGAAACT

CCCAAAAATGAGTTGTATAATATTACAGTCCTGGCAATAGACAAAGATGATAGATCATGT

ACTGGAACACTTGCTGTGAACATTGAAGATGTAAATGATAATCCACCAGAAATACTTCAA

GAATATGTAGTCATTTGCAAACCAAAAATGGGGTATACCGACATTTTAGCTGTTGATCCT

GATGAACCTGTCCATGGAGCTCCATTTTATTTCAGTTTGCCCAATACTTCTCCAGAAATC

AGTAGACTGTGGAGCCTCACCAAAGTTAATGATACAGCTGCCCGTCTTTCATATCAGAAA

AATGCTGGATTTCAAGAATATACCATTCCTATTACTGTAAAAGACAGGGCCGGCCAAGCT

GCAACAAAATTATTGAGAGTTAATCTGTGTGAATGTACTCATCCAACTCAGTGTCGTGCG

ACTTCAAGGAGTACAGGAGTAATACTTGGAAAATGGGCAATCCTTGCAATATTACTGGGT

ATAGCACTGCTCTTTTCTGTATTGCTAACTTTAGTATGTGGAGTTTTTGGTGCAACTAAA

GGGAAACGTTTTCCTGAAGATTTAGCACAGCAAAACTTAATTATATCAAACACAGAAGCA

CCTGGAGACGATAGAGTGTGCTCTGCCAATGGATTTATGACCCAAACTACCAACAACTCT

AGCCAAGGTTTTTGTGGTACTATGGGATCAGGAATGAAAAATGGAGGGCAGGAAACCATT

GAAATGATGAAAGGAGGAAACCAGACCTTGGAATCCTGCCGGGGGGCTGGGCATCATCAT

ACCCTGGACTCCTGCAGGGGAGGACACACGGAGGTGGACAACTGCAGATACACTTACTCG

GAGTGGCACAGTTTTACTCAACCCCGTCTCGGTGAAGAATCCATTAGAGGACACACTGGT

TAAAAATTAAACATAAAAGAAATTGCATCGATGTAATCAGAATGAAGACCGCATGCCATC

CCAAGATTATGTCCTCACTTATAACTATGAGGGAAGAGGATCTCCAGCTGGTTCTGTGGG

CTGCTGCAGTGAAAAGCAGGAAGAAGATGGCCTTGACTTTTTAAATAATTTGGAACCCAA

ATTTATTACATTAGCAGAAGCATGCACAAAGAGATAATGTCACAGTGCTACAATTAGGTC

TTTGTCAGACATTCTGGAGGTTTCCAAAAATAATATTGTAAAGTTCAATTTCAACATGTA

TGTATATGATGATTTTTTTCTCAATTTTGAATTATGCTACTCACCAATTTATATTTTTAA

AGCCAGTTGTTGCTTATCTTTTCCAAAAAGTGAAAAATGTTAAAACAGACAACTGGTAAA

TCTCAAACTCCAGCACTGGAATTAAGGTCTCTAAAGCATCTGCTCTTTTTTTTTTTTACG

GATATTTTAGTAATAAATATGCTGGATAAATATTAGTCCAACAATAGCTAAGTTATGCTA

ATATCACATTATTATGTATTCACTTTAAGTGATAGTTTAAAAAATAAACAAGAAATATTG

AGTATCACTATGTGAAGAAAGTTTTGGAAAAGAAACAATGAAGACTGAATTAAATTAAAA

ATGTTGCAGCTCATAAAGAATTGGGACTCACCCCTACTGCACTACCAAATTCATTTGACT

TTGGAGGCATAATGTGTTGAAGTGCCCTATGAAGTAGCAATTTTCTATAGGAATATAGTT

GGAAATAAATGTGTGTGTGTATATTATTATTAATCAATGCAATATTTAAAATGAAATGAG

AACAAAGAGGAAAATGGTAAAAACTTGAAATGAGGCTGGGGTATAGTTTGTCCTACAATA

GAAAAAAGAGAGAGCTTCCTAGGCCTGGGCTCTTAAATGCTGCATTATAACTGAGTCTAT

GAGGAAATAGTTCCTGTCCAATTTGTGTAATTTGTTTAAAATTGTAAATAAATTAAACTT

TTCTGGTTTCTGTGGGAAGGAAATAGGGAATCCAATGGAACAGTAGCTTTGCTTTGCAGT

CTGTTTCAAGATTTCTGCATCCACAAGTTAGTAGCAAACTGGGGAATACTCGCTGCAGCT

GGGGTTCCCTGCTTTTTGGTAGCAAGGGTCCAGAGATGAGGTGTTTTTTTCGGGGAGCTA

ATAACAAAAACATTTTAAAACTTACCTTTACTGAAGTTAAATCCTCTATTGCTGTTTCTA

TTCTCTCTTATAGTGACCAACATCTTTTTAATTTAGATCCAAATAACCATGTCCTCCTAG

AGTTTAGAGGCTAGAGGGAGCTGAGGGGAGGATCTTACTGAAAGCACCCTGGGGAGATTG

ATTGTCCTTAAACCTAAGCCCCACAAACTTGACACCTGATCAGGTCTGGGAGCTACAAAA

TTTCATTTTTCTCCTCACTGCCCTTCTTCTGAGTGGCATTGGCCTGAATCAAGGAAAGCC

AGGCCTTGTGGGCCCCCTTCTTTCGGCTTTCTGCTAAAGCAACACCTCCAGCAGAGATTC

CCTTAAGTGACTCCAGGTTTTCCACCATCCTTCAGCGTGAATTAATTTTTAATCAGTTTG

CTTTCTCCAGAGAAATTTTAAAATAATAGAAGAAATAGAAATTTTGAATGTATAAAAGAA

AAAGATCAAGTTGTCATTTTAGAACAGAGGGAACTTTGGGAGAAAGCAGCCCAAGTAGGT

TATTTGTACAGTCAGAGGGCAACAGGAAGATGCAGGCCTTCAAGGGCAAGGAGAGGCCAC

AAGGAATATGGGTGGGAGTAAAAGCAACATCGTCTGCTTCATACTTTTTCCTAGGCTTGG

CACTGCCTTTTCCTTTCTCAGGCCAATGGCAACTGCCATTTGAGTCCGGTGAGGGATCAG

CCAACCTCTTCTCTATGGCTCACCTTATTTGGAGTGAGAAATCAAGGAGACAGAGCTGAC

TGCATGATGAGTCTGAAGGCATTTGCAGGATGAGCCTGAACTGGTTGTGCAGAACAAACA

AGGCATTCATGGGAATTGTTGTATTCCTTCTGCAGCCCTCCTTCTGGGCACTAAGAAGGT

CTATGAATTAAATGCCTATCTAAAATTCTGATTTATTCCTACATTTTCTGTTTTCTAATT

TGACCCTAAAATCTATGTGTTTTAGACTTAGACTTTTTATTGCCCCCCCCCCCTTTTTTT

TTGAGACGGAGTCTCGCTCTGACGCACAGGCTGGAGTGCAGTGGCTCCGATCTCTGCTCA

CTGAAAGCTCCGCCTCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGG

GACTACAGGCGCCCACCACCACGCCCGGCTAATTTTTTGTATTTTTAATAGAGACGGGGT

TTCACTGTGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCGCCTGCCTCGGCC

TCCCAAAGTGCTGGGATTACAGGCATGACCCACCGCTCCCGGCCTTGTTTTCCGTTTAAA

GTCGTCTTCTTTTAATGTAATCATTTTGAACATGTGTGAAAGTTGATCATACGAATTGGA

TCAATCTTGAAATACTCAACCAAAAGACAGTCGAGAAGCCAGGGGGAGAAAGAACTCAGG

GCACAAAATATTGGTCTGAGAATGGAATTCTCTGTAAGCCTAGTTGCTGAAATTTCCTGC

TGTAACCAGAAGCCAGTTTTATCTAACGGCTACTGAAACACCCACTGTGTTTTGCTCACT

CCCACTCACCGATCAAAACCTGCTACCTCCCCAAGACTTTACTAGTGCCGATAAACTTTC

TCAAAGAGCAACCAGTATCACTTCCCTGTTTATAAAACCTCTAACCATCTCTTTGTTCTT

TGAACATGCTGAAAACCACCTGGTCTGCATGTATGCCCGAATTTGTAATTCTTTTCTCTC

AAATGAAAATTTAATTTTAGGGATTCATTTCTATATTTTCACATATGTAGTATTATTATT

TCCTTATATGTGTAAGGTGAAATTTATGGTATTTGAGTGTGCAAGAAAATATATTTTTAA

AGCTTTCATTTTTCCCCCAGTGAATGATTTAGAATTTTTTATGTAAATATACAGAATGTT

TTTTCTTACTTTTATAAGGAAGCAGCTGTCTAAAATGCAGTGGGGTTTGTTTTGCAATGT

TTTAAACAGAGTTTTAGTATTGCTATTAAAAGAAGTTACTTTGCTTTTAAAGAAACTTGG

CTGCTTAAAATAAGCAAAAATTGGATGCATAAAGTAATATTTACAGATGTGGGGAGATGT

AATAAAACAATATTAACTTGGAAAAAAAAAAAAAAAAAAA

>AA745593
GACTCAGNCTTCAGCCGCTCTCCTCCCCCTGGGCAAACAGGACTCATCTGATGATGTGAG

AAGAGTTCAGAGGAGGGAGAAAAATCGTATTGCCGCCCAGAAGAGCCGACAGAGGCAGAC

ACAGAAGGCCGACACCCTGCACCTGGAGAGCGAAGACCTGGAGAAACAGAACGCGGCTCT

ACGCAAGGAGATCAAGCAGCTCACAGAGGAACTGAAGTACTTCACGTCGGTGCTGAACAG

CCACGAGCCCCTGTGCTCGGTGCTGGCCGCCAGCACGCCCTCGCCCCCCGAGGTGGTGTA

CAGCGCCCACGCATTCCACCAACCTCATGTCAGCTCCCCGCGCTTCCAGCCCTGAGCTTC

CGATGCGGGGAGAGCAGAGCCTCGGGAGGGGCACACAGACTGTGGCAGAGCTGCGCCCAT

CCCGCAGAGGCCCCTGTCCACCTGGAGACCCGGAGACAGAGGCCTGGACAAGGAGTGAAC

ACGGGAACTGTCACGACTGGAAGGGCGTGAGGCCTCCCAGCAGTGCCGCAGCGTTTCGAG

GGGCGTGTGCTGGACCCCACCACTGTGGGTTGCAGGCCCAATGCAGAAGAGTATTAAGAA

AGATGCTCAAGTCCCATGGCACAGAGCAAGGCGGGCAGGGAACGGTTATTTTTCTAAATA

AATGCTTTAAAAGAAAAAAAAAAAAAAAAAAAAAAA

>AI985118
ATGCAAGGNNTAGGCAAAGATTGTTGACCCNGGAGATAGAGGTNNCAATGAGCCAGATCA

TTCCATTGCATTCCAGCTTGGGCGACAGAATGAGACTCTGTCTCAAAATTAAAAANCAAA

AAACCAAAANCAAATAGATGAAAAAGTAGACTGGAGACAAATAAAAGTGAGTTTCTAAAG

GAAATTCACAGTAATGCTGCATTAAACACTAAGCTCACTTAGGTCACTTTCTAGTGAGCT

AACCGTAACAGAGAGCCTACAGGATACACGTGAGATAATGTCACGTGTAGAAGATCGTTG

TGAATTAAAGTTCAAAATTAAGACTTCTTAGATTATGATGTAGATTTTAGAGCTCCTTAA

AACATAAAGCGAATCTTATAAATGTTCAATTCTAAAGTTATTCCACTTGGAAAAATTAGC

TTTTGGGACAATTTTTAAGAACTTTTGTGTAAAATGCAGCTCCATGTTTAGCATAATCTA

AAAATAATTTCAAGCAATCCAGAATCTTCCAAGAATGTTATTAAAGCTTTAAAACAAAGC

AAAACAAAAAGACCCTTTTGTGCCTTATATGGGAAGACTAAAAAAA

>AB038160
ACCGGGCACCGGACGGCTCGGGTACTTTCGTTCTTAATTAGGTCATGCCCGTGTGAGCCA

GGAAAGGGCTGTGTTTATGGGAAGCCAGTAACACTGTGGCCTACTATCTCTTCCGTGGTG

CCATCTACATTTTTGGGACTCGGGAATTATGAGGTAGAGGTGGAGGCGGAGCCGGATGTC

AGAGGTCCTGAAATAGTCACCATGGGGGAAAATGATCCGCCTGCTGTTGAAGCCCCCTTC

TCATTCCGATCGCTTTTTGGCCTTGATGATTTGAAAATAAGTCCTGTTGCACCAGATGCA

GATGCTGTTGCTGCACAGATCCTGTCACTGCTGCCATTGAAGTTTTTTCCAATCATCGTC

ATTGGGATCATTGCATTGATATTAGCACTGGCCATTGGTCTGGGCATCCACTTCGACTGC

TCAGGGAAGTACAGATGTCGCTCATCCTTTAAGTGTATCGAGCTGATAGCTCGATGTGAC

GGAGTCTCGGATTGCAAAGACGGGGAGGACGAGTACCGCTGTGTCCGGGTGGGTGGTCAG

AATGCCGTGCTCCAGGTGTTCACAGCTGCTTCGTGGAAGACCATGTGCTCCGATGACTGG

AAGGGTCACTACGCAAATGTTGCCTGTGCCCAACTGGGTTTCCCAAGCTATGTGAGTTCA

GATAACCTCAGAGTGAGCTCGCTGGAGGGGCAGTTCCGGGAGGAGTTTGTGTCCATCGAT

CACCTCTTGCCAGATGACAAGGTGACTGCATTACACCACTCAGTATATGTGAGGGAGGGA

TGTGCCTCTGGCCACGTGGTTACCTTGCAGTGCACAGCCTGTGGTCATAGAAGGGGCTAC

AGCTCACGCATCGTGGGTGGAAACATGTCCTTGCTCTCGCAGTGGCCCTGGCAGGCCAGC

CTTCAGTTCCAGGGCTACCACCTGTGCGGGGGCTCTGTCATCACGCCCCTGTGGATCATC

ACTGCTGCACACTGTGTTTATGACTTGTACCTCCCCAAGTCATGGACCATCCAGGTGGGT

CTAGTTTCCCTGTTGGACAATCCAGCCCCATCCCACTTGGTGGAGAAGATTGTCTACCAC

AGCAAGTACAAGCCAAAGAGGCTGGGCAATGACATCGCCCTTATGAAGCTGGCCGGGCCA

CTCACGTTCAATGGTACATCTGGGTCTCTATGTGGTTCTGCAGCTCTTCCTTTGTTTCAA

GAGGATTTGCAATTGCTCATTGAAGCATTCTTATGATGGCTGCTTTATAATCCTTGTCAG

ATATTAATAATTCCAACTCCTGATTCATGTTGGTGTTGGCATCAGTTGATTATCTTTTCT

CATTAAAATTGTGATGCTCCTAAAAAAAAAAAAAAAAAA

>X69699
TTCAGAAGGAGGAGAGACACCGGGCCCAGGGCACCCTCGCGGGCGGGCGGACCCAAGCAG

TGAGGGCCTGCAGCCGGCCGGCCAGGGCAGCGGCAGGCGCGGCCCGGACCTACGGGAGGA

AGCCCCGAGCCCTCGGCGGGCTGCGAGCGACTCCCCGGCGATGCCTCACAACTCCATCAG

ATCTGGCCATGGAGGGCTGAACCAGCTGGGAGGGGCCTTTGTGAATGGCAGACCTCTGCC

GGAAGTGGTCCGCCAGCGCATCGTAGACCTGGCCCACCAGGGTGTAAGGCCCTGCGACAT

CTCTCGCCAGCTCCGCGTCAGCCATGGCTGCGTCAGCAAGATCCTTGGCAGGTACTACGA

GACTGGCAGCATCCGGCCTGGAGTGATAGGGGGCTCCAAGCCCAAGGTGGCCACCCCCAA

GGTGGTGGAGAAGATTGGGGACTACAAACGCCAGAACCCTACCATGTTTGCCTGGGAGAT

CCGAGACCGGCTCCTGGCTGAGGGCGTCTGTGACAATGACACTGTGCCCAGTGTCAGCTC

CATTAATAGAATCATCCGGACCAAAGTGCAGCAACCATTCAACCTCCCTATGGACAGCTG

CGTGGCCACCAAGTCCCTGAGTCCCGGACACACGCTGATCCCCAGCTCAGCTGTAACTCC

CCCGGAGTCACCCCAGTCGGATTCCCTGGGCTCCACCTACTCCATCAATGGGCTCCTGGG

CATCGCTCAGCCTGGCAGCGACAAGAGGAAAATGGATGACAGTGATCAGGATAGCTGCCG

ACTAAGCATTGACTCACAGAGCAGCAGCAGCGGACCCCGAAAGCACCTTCGCACGGATGC

CTTCAGCCAGCACCACCTCGAGCCGCTCGAGTGCCCATTTGAGCGGCAGCACTACCCAGA

GGCCTATGCCTCCCCCAGCCACACCAAAGGCGAGCAGGGCCTCTACCCGCTGCCCTTGCT

CAACAGCACCCTGGACGACGGGAAGGCCACCCTGACCCCTTCCAACACGCCACTGGGGCG

CAACCTCTCGACTCACCAGACCTACCCCGTGGTGGCAGATCCTCACTCACCCTTGGCCAT

AAAGCAGGAAACCCCCGAGGTGTCCAGTTCTAGCTCCACCCCTTGCTCTTTATCTAGCTC

CGCCCTTTTGGATCTGCAGCAAGTCGGCTCCGGGGTCCCGCCCTTCAATGCCTTTCCCCA

TGCTGCCTCCGTGTACGGGCAGTTCACGGGCCAGGCCCTCCTCTCAGGGCGAGAGATGGT

GGGGCCCACGCTGCCCGGATACCCACCCCACATCCCCACCAGCGGACAGGGCAGCTATGC

CTCCTCTGCCATCGCAGGCATGGTGGCAGGAAGTGAATACTCTGGCAATGCCTATGGCCA

CACCCCCTACTCCTCCTACAGCGAGGCCTGGGGCTTCCCCAACTCCAGCTTGCTGAGTTC

CCCATATTATTACAGTTCCACATCAAGGCCGAGTGCACCGCCCACCACTGCCACGGCCTT

TGACCATCTGTAGTTGCCATGGGGACAGTGGGAGCGACTGAGCAACAGGAGGACTCAGCC

TGGGACAGGCCCCAGAGAGTCACACAAAGGAATCTTTATTATTACATGAAAAATAACCAC

AAGTCCAGCATTGCGGCACACTCCCTGTGTGGTTAATTTAATGAACCATGAAAGACAGGA

TGACCTTGGACAAGGCCAAACTGTCCTCCAAGACTCCTTAATGAGGGGCAGGAGTCCCAG

GGAAAGAGAACCATGCCATGCTGAAAAAGACAAAATTGAAGAAGAAATGTAGCCCCAGCC

GGTACCCTCCAAAGGAGAGAAGAAGCAATAGCCGAGGAACTTGGGGGGATGGCGAATGGT

TCCTGCCCGGGCCCAAGGGTGCACAGGGCACCTCCATGGCTCCATTATTAACACAACTCT

AGCAATTATGGACCATAAGCACTTCCCTCCAGCCCACAAGTCACAGCCTGGTGCCGAGGC

TCTGCTCACCAGCCACCCAGGGAGTCACCTCCCTCAGCCTCCCGCCTGCCCCACACGGAG

GCTCTGGCTGTCCTCTTTCCTCCACTCCATTTGCTTGGCTCTTTCTACACCTCCCTCTTG

GATGGGCTGAGGGCTGGAGCGAGTCCCTCAGAAATTCCACCAGGCTGTCAGCTGACCTCT

TTTTCCTGCTGCTGTGAAGGTATAGCACCACCCAGGTCCTCCTGCAGTGCGGCATCCCCT

TGGCAGCTGCCGTCAGCCAGGCCAGCCCCAGGGAGCTTAAAACAGACATTCCACAGGGCC

TGGGCCCCTGGGAGGTGAGGTGTGGTGTGCGGCTTCACCCAGGGCAGAACAAGGCAGAAT

CGCAGGAAACCCGCTTCCCCTTCCTGACAGCTCCTGCCAAGCCAAATGTGCTTCCTGCAG

CTCACGCCCACCAGCTACTGAAGGGACCCAAGGCACCCCCTGAAGCCAGCGATAGAGGGT

CCCTCTCTGCTCCCCAGCAGCTCCTGCCCCCAAGGCCTGACTGTATATACTGTAAATGAA

ACTTTGTTTGGGTCAAGCTTCCTTCTTTCTAACCCCCAGACTTTGGCCTCTGAGTGAAAT

GTCTCTCTTTGCCCTGTGGGGCTTCTCTCCTTGATGCTTCTTTCTTTTTTTAAAGACAAC

CTGCCATTACCACATGACTCAATAAACCATTGCTCTTCAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAA

>AK025615
TGCTTCATAAAATTTACCTAAGCAAGTGGTCTTGCTTGCCTCAAATCCAAGCAGTCTTGA

ACACTTGGAGGCAATTAATGAGTATATCTTAGTCAAAAGAATTGTTGGAGCTTTTTATTA

AAGCTGCAGTTTCAGTTCTGCTTTTGGGGAATTGTGCTATGAAAGCAGCTGCCAAAATAA

GCTCATTTATTTTCTTCAATCCCACTCAGTGCTCAGTCACTATATTCTGTTTCCTTTTTT

TTTTTCAAGTTGCATATTTGGTTTCCCCTTATGATTGGGAAAGATGAATTTTCAGCAGAA

AACAGTGTTTGTTCACTTTCAAAGAGTGATAGTTTCTAAAACATTTAGAGCAATAAATAT

TCATCAGAGGTACCAAGTAAGCCAGCAGAAGAGTTAAGGGTTAGAGAAATCCCTTATTTC

ATGTCTTGACTCTAAAATGATCAAAGTACTTTTCCTTGTAATGTGGATTTCTTCTTATGC

GGATATGCAAAAACTTCAGTTATACGTAGTAATGCTAGCAGGTAATTTTAGTGGACATTT

TATAACAACTGTCACTTTGTTTTGCCACATGTAGAGTTTGTTCAGCTATTTTCCAGATAT

CTCCCCACAAAAGGAGGCAAAGGGTACCAGCTTTTCAATGAGCATTACCTATTACTTGGC

AAAGATGATGAAGACTCTATTAATAGTTCATTTGATAAATGTTGACATAACCAACAATAG

AGATTAGGAAGTTAGTTTTAAGAAATCAATAGCATATAGACATTACCCTCATGGAGTTTG

TATTCTACTACTTGAACTGATTGTAGCTATAAAAGCATAGTTAGATAGCTGAATAGTTAG

ATCATAAGCAAAGAAGGCCAGAACACATCTCTTATCAAGAAATCAATGAATAGTTTATCT

CATTTTTAAAGCAACTTTATCCTTCTTTAATTCCTTCCTTTCTTCTAGTGCAAAACTACT

TAATAAGGTTGGTGTTTAGGTTAGTGTTCACACCATTCCTCATCTGGTGTGAATTACCTT

CTCTTTCTTTACTATTTACTACCAACCTAGTACATGTGTTGACTGAATTCTTTTCAAACA

ATGTTGAGTTATCATGGTGCACCTAATAAATTAACACCACAGATTACAGCATCCTTGCTG

ATTTTCTCAGCAAAGCCAGATTAGATGGAAATAAACAAAGAAAATGATCCTAGAGTGAAT

TTTTCTAGAAAATATCTATTATGAACCATGCTGTTTAAAGTATTAGCTTGAAGGTGATGG

ATCCAGCTATTCAGAAAATAACTTTCATATAACCATGATTTTGCACAGTATGAGGTCTTA

AATGTGTGGAAAGAGATAAATTTTTTATCATTACCACAAACCCCTTTTAAAGATTCAAAG

GTGGAAGAAAGTGATTTATTTTTTCTCTTCAGCATACATATATAAAAGACTTGTCAGATG

TTTAATTTGGGGAGGTTGATAATGAAACATATCAACAGAGTATAGTAGTTATAGTAGTGT

TTGTGGGTAAATAATTTCCTGGGGTCAGACATATATAAACATATTTGCTTCAAAATGATA

AAGGCATGAAATCAGTCTTAAAAATTGAAATGGGGGTGATGGGGGAGAAAAAGAAGAACA

AATTTGAAGTGCCCTTTCAAATCTGCTGGATACAAGTATTGAAGTTTTAAGTCATCTTAT

TCTGTCTGAAAGTGTATTTTTCATTCTACAATAGACCCAATCAACAAGACGTATAACTTG

AGTTGCATGATGTTCAGTTTATGTAATCTACTGTTGGGATGGTAAGAATTGATGTAGGCT

GTGGTGTAAGAATGAATTAAAATATAGTTTCACTGGCTTTTCTCTACATATCCACTATCA

CAATGGCTAGGTTTCCTGTTGCTCACTGTTGGATTCTGGAGAAAAATTTAATGAAAGATG

ATATCAGAGGAAGAATAAGTGGAGGTAGAGAAGAAAGGAGTGATAGAGGAGGGGAAAAAA

ACAAAACATATTTTTGTGTTATCCAAAGGAGCTTTTTCCTTATTCTGTCAAGCATTGAGA

TCTTCTTCAGCTTTCAATGTAGTTGCTAAATACAAATAATGCTACTAGGTAGTGACTAAA

TATAGCAAACACTTCATCAGATATTAGAATTAGGTCACACTATTGAGGTTATAATCTGAA

GGTTGTGTTACATAGAAACCACTTTAGATTATTATCAACTTGGGCTAGGCTTTATTTTAT

AATAGCATAGTAAGTAATATCTATTGTGTCATTTCTTCAACCATTTTATTCTAAGATCCA

TGAAGCTTCTTGAGGCCAAATAAAATAATAAGTTTAGACAAGAAGTAGATTGTGACTTTT

TTTCCCTTAGAGATACTATTTACTATCTCCTATCCTGATAGGTGGAAGGTTTACTGAATT

GGAAATTGGTTGACTATTAGTTTTTAACTAAAATGTGCAATAACACATTGCAGTTTCCTC

AAACTAGTTTCCTATGATCATTAAACTCATTCTCAGGGTTAAGAAAGGAATGTAAATTTC

TGCCTCAATTTGTACTTCATCAATAAGTTTTTGAAGAGTGCAGATTTTTAGTCAGGTCTT

AAAAATAAACTCACAAATCTGGATGCATTTCTAAATTCTGCAAATGTTTCCTGGGGTGAC

TTAACAAGGAATAATCCCACAATATACCTAGCTACCTAATACATGGAGCTGGGGCTCAAC

CCACTGTTTTTAAGGATTTGCGCTTACTTGTGGCTGAGGAAAAATAAGTAGTTCGAGGAA

GTAGTTTTTAAATGTGAGCTTATAGATAGAAACAGAATATCAACTTAATTATGAAATTGT

TAGAACCTGTTCTCTTGTATCTGAATCTGATTGCAATTACTATTGTACTGATAGACTCCA

GCCATTGCAAGTCTCAGATATCTTAGCTGTGTAGTGATTCTTGAAATTCTTTTTAAGAAA

AATTGAGTAGAAAGAAATAAACCCTTTGTAAATGAGGCTTGGCTTTTGTGAAAGATCATC

CGCAGGCTATGTTAAAAGGATTTTAGCTCACTAAAAGTGTAATAATGGAAATGTGGAAAA

TATCGTAGGTAAAGGAAACTACCTCATGCTCTGAAGGTTTTGTAGAAGCACAATTAAACA

TCTAAAATGGCTTTGTTACACCAGAGCCATCTGGTGTGAAGAACTCTATATTTGTATGTT

GAGAGGGCATGGAATAATTGTATTTTGCTGGCAATAGACACATTCTTTATTATTTGCAGA

TTCCTCATCAAATCTGTAATTATGCACAGTTTCTGTTATCAATAAAACAAAAGAATCCTG

TTAAAAAAAAAAAAAAAAAAAAA

>AW118445
TGGCTCTCTCCTTCAAAAGGNCCAGGCCCTGTCCCCCTTTCTCCCCGANTCCAACCCCAG

CTCCCCTGTGAAGAAAAAAGTTAAAAAATTTGTTATTTATTTGCTTTTTGCGTTGGGATG

GGTTCGTGTCCAGTCCCGGGGGTCTGATATGGCCATCACAGGCTGGGTGTTCCCAGCAGC

CCTGGCTTGGGGGCTTGACGCCCTTCCCCTTGCCCCAGGCCATCATCTCCCCACCTCTCC

TCCCCTCTCCTCAGTTTTGCCGACTGCTTTTCATCTGAGTCACCATTTACTCCAAGCATG

TATTCCAGACTTGTCACTGACTTTCCTTCTGGAGCAGGTGGCTAGAAAAAGAGGCTGTGG

GCAGGAAAGAAAGGCTCCTGTTTCTCATTTGTGAGGCCAGCCTCTGGCTTTTCTGCCGTG

GATTCTCCCCCTGTCTTCTCCCCTCAGCAATTCCTGCAAAGGGTTAAAAATTTAACTGGT

TTTTACTACTGATGACTTGATTTAAAAAAAATACAAAGATGCTGGATGCTAACTTGATAC

TAACCATCAGATTGTACAGTTTGGTTGTTGCTGTAAATATGGTAGCGTTTTGTTGTTGTT

GTTTTTTCATGCCCCATACTACTGAATAAACTAGTTCTGTGCGGGTAAAAAAAAAAAAAA

AAAAAAAAAAA

>AL137761
CACAAAGAAAAAAGAAATACCTGTAGAAGCGCATCGAAAGCTCCTGGAACAGAGTTGTGT

CTCATATTTGCAAAGATGCAGAAAAAATAAACCCGGGACATCCAGCTTTCTTTTCCTTTC

TTCTTTGACTATTCTGAGAAGCTATGCGACTAGGAGCACATTTTAGGTAAACACGTGGCT

TGAGTAGCCATAAGGCCACTCTTCCCTGTCGTGTGACCCGCGCCTGGGCCTTTAAGAGAT

ATTGGTGTTTGAAAAGGGAGGAATCTGTTTGCCCTCAGATATTTAGTTCAACTGCCTGCA

TTGCTTCCTATTTTGTTGTCCAACTCTGTAGTAGTTAGCACTGGCCTTACCAACATGTAA

AGAAATTTTCTTTACTGCCCCATGAGTAGTTGGAGGCAAAGAGAAATTTTTAAAGCGCAG

AAAAAGGCCTGCAGGGAGATGGAATTTGTTCTGCCAGAGAAACGAGATGATAGCTGTATT

TAATAAAGTTACTGACCTCTTGTCAAAATTTAAAACGCAAAAGAAGATGTTTCAAAATGC

AGAGAATGTCAGAAAACAAAAACTACAGGGACCAGACCAGTATAATGTTTAGTTTTCATT

ATACTAACTTTTGTCTAGACTGGAGTTGATTCACTATTTTTTCTTTAACTCCTCAGGAAG

CAAACCTTCCCGATGATGAAGACTTCTTGAAGGATTTCATGGGTGATTTGGGATCCCAGG

ACCATTTGGCTAGTGTGCCTAGGTGACCACATGATTGCTGTTTTACCAGGAATGCAGCAT

CCCATTGACAAAACAAGTGCTCTGAGAAGGTTTAAAATACTACAGAGAATATGGGAACAC

AGACCTTGAAATTTAGCTGAGTTGTAACAGCTGAAACTCCAAGAGGTGTCTTCCTTGTTT

GAGGTGAAACTAGTGTTGCTTCCAGAGGGCAGCTGGAAACCGTAAAGCTGTTTGGAAATC

TTTTTGACTGACTTGCTGACAAAGAGGTACTGTGATGCATTTTAACAATATCTAAGTTGA

TTTTTTTTTAAATCAAGGAAAATAAAAACCAAGCATGAATGCTATGGTATGTGCCCCTTT

TGACCATCCTGGGCTGATTAACATCATTTAAATCAAAGTAATCATAAAAAGGCATATTCT

ACTTCAATTATGTGGTCAAATAAGAGTAAACACACACACTCACACATGCTGACCCCAATT

GCCAGAGCATTACTGCACTATAAATTACGGTTAATTCCCAAATTATACTACTGTTTATCT

TATTTAACAAGTCAGAAAGCACTTTTAAAATAACTTGAGGGCTACAAGGTCATTCTATTA

ATGTCATTCTCCATTCGGGTTGTAGGCATGTGGAAGTACCCATTAAAAGATAAGTTAGAG

TTTAAATACTGATAAACAAAACCTTTTATTGCAACTGGACAGTTTCTGGAGAGTTAGCGG

AAGAATCTTGGAGTTTCCTTTGGTCAGATGAATACAACATTTCACTTTTGCAGCACTATT

TAGAATGTACTCCATGGTTCTCTTGTTCCCAACTTCCAAAAAGAACAGAAAACTTTGGTT

TACACAGAACACGGGCATCTGAGGCAGGACCTCTTCCCTGCCCTTTGATCTGACTCACAC

CTCCACATATGACGTAATCAACCCAAATTTGACACCAATTCACTCTTTTCTGCAAAGGGC

ATATTTTGAAACAAGGGACAGCCTGAGGGCGGCTATAATGAGAATGTTCATGGGGGTTAC

TGGGTCCCTAATTCTGAACTTGCTTATGACACCCAGAGTGAATAGATTCAGATTCAGAAC

CTTCTGAGAAATAACCCAAAGAAAATTTGTTACCCAGCCAATTCTTCGAAAGCTTAATAT

CAAAATATATCTTTTCAAGAAGAAAATCGTTAGAGAGAAGAATGTGGAGGGGAGAGAAAT

GGGTTTCTCATTGATATGATATTTTGTTAACCATTTCATTTTGAATTATTCAAGTTTTGG

TTAATATTGTATTCTTTTTTCGTAACTATTTTACCGTGAGAGTAGGTCATTGGGTTACTT

AGATATTTATTTTTACACAGTTATTAGTCTTCAGATAGTTTTATTTTACTTCATATGATT

TTAGTTTTTGTCAGTATAATTTTAAATCATGTTTTTCTTGGTCATCTCTTTGTGTATATT

GTGTAATTGGATTTTCATTGACTGCAAGTGGAGTGTTTGCCACTCAATTCAGTACTCAGT

ACTATGGTGACTTGTTTTCAAATAAGTCTCAGATACACATTTAGGGAGCCTTTGCTGGCC

GAATATAGACTCTGTCAGGACAGCAGGTCCCCTGATCTAAGAATTTTCCCCAATGGTTGC

TCTAAAAATGCTGCTATTTTGCTGTTCACTGTATTGCACTTAGTTAAAAAGAAGATAATG

TGAAAGATGAGAGCAGTTTTTTAAAGGATCTTTTCATATACCCAATTCCCTTATTTTCAG

ATGTCCCATCAATTTTAGATATGAAAGCTTTAAGTAAAAGTGTGTATGCCTTTCTACTGT

CAGAACAGGATGGATGCAGCCTGGGTCAGATTTATTTAAGATAAAAATCATGCAGACTCA

TCATTCATATCATAGGTGAAAAATGTAAAAACCAAATGGTTTCCACTAAAGCCACCAAGA

TCTTTTAGAAATGTTTGCACCTTTGGTGGTGGCACAGGAAAAGAGAAGAATTCAGCTGGA

GTGAATTCTAGAAGTAGATATCAGAAACGGGGCATGAAGAACAGGGGAACTGGGTGGCAT

CAGACTCCTAAAGAAGTGAGTTAATTTTCCTTCCCTTCCATTCAGATTCATGCCACAGCT

CCATATCTTGAGTATGTGTAAGAGGTGAGTTCCTTCTTCAGCCAGGGGCGGTGGCTCATG

CCTTTAATCCCAATGCTTTGGGAGGCCAAGGTGGGAGGATCACTTGTGCCTTGGGGTTCA

AGGTTGCAGTGAACCATGATTGCACCACTGCACTCCAGCCTGAGTGACAGAGCAAGACCC

TGTCTCTAAAAATATATATAAAAAGTAAAACTAAAGAACTTCTTGCCTAAACCTGAATTA

CCGCAATTTGCTGAGTGACTTTGAGAAAAATCAGACTGTTTAGTTCAGTCGGGATGAAAA

GCTTGCGATTGCTTCCCACAAGAATGGGCAATAGTGACGGCTGCAAGGTACTTTTATTTG

TTCATGAAAGAACGACAATTTTTCAAAATGTAATTAAACATAATAGAATGTTTTAAACTA

CTGGGCACTGAAACTGGAAGAAAAAGGAGGCTTTATTGAACATTCCCCTTTTTCAGTTGG

TTCAAAGTTCAGCACTGTGGTTATCATTGGTGATGCCAGAAAACATTAGTAGACTTAGAC

AATTGCTATGGCAGTTTCTAAACAGAGCTTTTTCTATACACTATTTGCAACTGGAGTGCA

ATATTGTATATTCTGTGTTAAAGAAATAAAGTATTTTTATCATTTATTAAAAAAAAAAAA

AAAAA

>AF038191
CCATCCAGAACGATGAGGCCGTGGCCCCGCTCATGAAGTACCTGGATGAGAAGCTGGCCC

TGCTGAACGCCTCGCTGGTGAAGGGGAACCTGAGCAGGGTGCTGGAGGCCCTGTGGGAGC

TACTCCTCCAGGCCATTCTGCAGGCGCTGGGTGCAAACCGTGACGTCTCTGCTGATTTCT

ACAGCCGCTTCCATTTCACGCTGGAGGCCCTGGTCAGTTTTTTCCACGCAGAGGGTCAGG

GTTTGCCCCTGGAGAGCCTGAGGGATGGAAGCTACAAGAGGCTGAAGGAGGAGCTGCGGC

TGCACAAATGTTCCACCCGCGAGTGCATCGAGCAGTTCTACCTGGACAAGCTCAAACAGA

GGACCCTGGAGCAGAACCGGTTTGGACGCCTGAGCGTCCGTTGCCATTACGAGGCGGCTG

AGCAGCGGCTGGCCGTGGAGGTGCTGCACGCCGCGGACCTGCTCCCCCTGGATGCCAACG

GCTTAAGTGACCCCTTTGTGATTGTGGAGCTGGGCCCACCGCATCTCTTTCCACTGGTCC

GCAGCCAGAGGACCCAGGTGAAGACCCGGACGCTGCACCCTGTATACGACGAACTCTTCT

ACTTTTCCGTGCCTGCCGAGGCGTGCCGCCGCCGCGCGGCCTGTGTGTTGTTCACCGTCA

TGGACCACGACTGGCTGTCCACCAACGACTTCGCTGGGGAGGCGGCCCTCGGCCTAGGTG

GCGTCACTGGTGTCGCCCGGCCCCAGGTGGGCGGGGGTGCAAGGGCTGGGCAGCCTGTCA

CCCTGCACCTGTGCCGGCCCAGAGCCCAGGTGAGATCTGCGCTGAGGAGGCTGGAAGGCC

GCACCAGCAAGGAGGCGCAGGAGTTCGTGAAGAAACTCAAGGAGCTGGAGAAGTGCATGG

AGGCGGACCCCTGAGTCCATCAGCTGCCAGCCCCGGCCCTGGCCCCCACCCCAAGTTCCC

TGAAGCATCCTCCAGCTCACTGTGGCCAGCTTTGTGCAACCAGGGCCCACGGCGCCCCTC

CTGTGCTGTGACGTGTGTGTCGTGGCTGGCCCCGCGGCGCCTACCGCCCTGGCCGTGTCT

GTCTGGTGTGTGCTGTGAACCCCTGCACCCAACCCCACATCTGGGTGGCCAACTTGGCAG

GACTTGGCCAGCAGCTGCCCAGGACACAGTGCAGGCCAGAGCGGGCTTGACCACCTGGTG

GGCCTCCCTGCCCGCTTCCTTGGGCTCCCCGGCCCTGGGTGGGCGGTGCGCAGCTGGTCT

CCAGGGACTCAGTGAGTGGCTGTGCTCTCTGCACAACGGGCAATGTGCAGACGCATTTTT

GGTAATCACAGCTGGGGAGTGAAAAGGGTGCCACTGGCACCACTGGGTGGATGGTCCAGA

GCCTCCACCCACAGAGGGGATGCAAAGGGCAGGTGAGTCAAGAACCGCATAGGTCTCCAG

TCCCCACGGGGCTCCCAGGCCGGGGAAAGGTTCCCCTGAGGTCACTCTGAGGCCAGGGAC

GTCACCCAAGGCTGGTGGTCAGTGTGAAGGGCTCCGTGCCAACTGGTCAGCTGTCCTTCA

CGCACATATCCGTGGCCACCTGAGACCTGCTCCACGACCCTTCCAGGCAGAGCCGAGAGT

TCGCCCCAACCCTTCCCCAGGCCCAGTGTGAAAAACAGACTCACAAGGGGCTTCTTGGCC

TGCAGCTTCATTTGCGAGAGCGCCGAGGCAGGACACAGAGCACAGCTGTGCTGGAAGTGT

GGGGAGAACCCGGACAGCTCAGTCCTGCCAGCAGCCGCAAAGAGCCGAGGCTGCCAGGCC

CATTTATGTCCCTCATGTCTCTAGATTTTCTCGTCACCCAGCCTCAAAAATATATGTGTC

TGCAACCCTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>BC016340
GGGGGGGCTCCGTGACAGCCAACGCAGTGACCCTCGCCCCTTCCTTGGCAGCACATCATG

CTTGTGCAGCGGCAGATGTCTGTGATGGAAGAGGACCTGGAAGAATTCCAGCTCGCTCTG

AAACACTACGTGGAGAGTGCTTCCTCCCAAAGTGGATGCTTGCGTATTTCTATACAGAAG

CTTTCAAATGAATCTCGCTACATGATCTATGAGTTCTGGGAGAATAGTAGTGTATGGAAT

AGCCACCTTCAGACAAATTATAGCAAGACATTCCAAAGAAGTAATGTGGATTTCTTGGAA

ACTCCAGAACTCACATCTACAATGCTAGTTCCTGCTTCGTGGTGGATCCTGAACAACTAG

ATGTTCCTAGACATTTTCTTTATGGTTCCAAGTGCAAAACAGGTGTTCTTATCTAAAACG

TCAATTAGAAAATTATCTGCGGTTGTTAATCTACTGTATATTTTTGTTTGGTATATTTAC

TAAGTGCACTCTTTCAAAACTTATTCTATAACTTTATCAATTCATGTGAATTTTAGCTCA

ATTTTCAAAGTTCACTAATATTCTCAATATTTAATGCTAAATGCTTTGCTACATTGTAAC

TCACCTAAAACCTTTTAGTGACAAAATCCTAATATGTGGAAAAAAGCATATGCATAAAGG

AATAATATTGTGAAAATGAATCTGTTATGATAAAGAAAAAATAAAGTGGAAACTTTTAGA

GTATTACTTCATAGGGCAGATTTTGTAAACTGTCGTATACTGTAAAGGGTTAAATCAGCG

TTTTGTGATTTTTAAGTAACTGTGAGTGAAGTTTATTCTTCAACAATGTCTACTCCATCC

CCAACCCAACTCACAGCCCTATGACTACTATCTTTGCATTAGTTAAAAAGTTAGTATATA

GGCATCAAACAACCTTGGCTGTAACCTATAGAATCTCTATCCATGTATCAGGTTATAGAC

TGGTTTTTCAAAAGTGAACAATCCTGTGATAAGTTGGAGTACCATTTAGTAATACAGCAA

CATTGTGTCATTTATTAGCATCATAATTCTTTGTTATGTAAGTTAAATATATCAAGAAAG

AAGAGACTGTTTGGAAAAATGTGGTTCAAGTTTTATGCTATATAGTTTTGGTATGCGATA

CAGACAGCTAACTTTTCTTATGAAAAATACATATTTGCATGTAAACAATGATTTCAAAAT

ACTTGAAAAATAAAATTTTAACCCAAATGAATAACTAAGAAATATAAAACAAGCACAAAA

TCTTAGGGAAGTCATAAAATAGTAGTGAAAGTATTAGACAGAAGACATCTGTTTTCGAAT

TTCAACACTAGAATGACTAAAACTATCTACCTATAGAACTATCTGTAGATAGTATACTAT

CTACACTCTGCTCAACAAGCTCAGAAATTAAATATTTTTAGTAATAAAAATCTGTTCTGG

TTATAAACCTTGCTAATGAAAATACAATACATATAAAAATGTATAGCCATGTTATTTTCT

AGTATAAATTCCTTTGAAACTATAAGTCTTTGAGGAAAATTATAAGGTAAAATTTTCCTG

TTTTTCCCCCTTTGAAAAACTCAGGAAAAAAGGAAGATTGAACTAATAAAATTTTATTTC

TTAAATATAAATTTGACCTAAAATATTTTCTCAAACTAATTCATGAAACAGCAACTTTTA

CCAATACCTTTGTATACTCTCAGTTCTCATTCAGTATAAATAAAATTTTAAAATCCTTTC

ATAGTTCTATTAGAAATAAGTAGTAAATTTTGATATATTGTACATACACACGTGTGTGTG

TGTGTGTGTGTGTGTGTGTATTTGTGTGCCTCTGGTCAACTCTAAGGATGACAGACACTG

TGTAACAACACCTGGGTCAACTCTTTTAATTTATATACAAAGCAAAGAACAACATTAATG

GAGATGCACAATGATTATTCAAACAAGCTATATATATGTACAAAGGCAAACAGACACATA

ACAGTCTCTGCAGACTGATTGTATATAGTAAGAAAAGATCAAAAGACTTTAAAACCTAAA

TGACTTTTGACATACAAACTCTTCTTGAGAATGTTTGTTGTAAATGGTTTCAAAAATACA

AATTATAGCCAATCAAAACATTGCTTTGGTTGGTGCATTTAAGTATCCAACTCAAAAAGC

ATATCAAATATTTTGGGTACTAGGCAGTTTCCAAAGTAGCATGGTAGTATTACTTGTTAA

AAGGGTTCTGTTTTCATTAACAGTACTAAGTGGAAGGGATCTGCAGATTCCAAATTGGAA

TAAGCTCTATCATATTCTGAAACAAGAATTAGAATGACTTGAGAACGGGCAAATAACAAA

GCAAACCAATATAATTATATGGTCATTCTGACCCCAGCTCTTATACAAATTATACATGTA

TTTTTGTGTATGTTTGTGAGAGTTGTATGTATGTGAATGTGTGTGAGTGTGTATTCACAT

ACACATATATACTGGAACCTATAGTAGAAAAGGAAACTAGTAGGGCCAAAAAAAAAAAGA

AAAAGAAAAAGAAAAAAGAAAAAAAAAGAAAAAACTGGGACCTAAGTATAAATATCTCAT

CCTAAAGTAAACAATAAGTTTATAGTTAACGAAGATTTTTTTCTATTTAAAACCCCATTT

TCCTAAAGAACAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>BC013282
GGCACGAGGGCAGGGGGAAGGGAAGTGCGGCTCGGTCGGCGCGGGTGGAGGGGGCGTGAG

GCCGCCCTACGGTGGCCGTCGAGGGACGGCGCTACGGCTCCCACGCTAGGCCAAACGCCT

CCGGCGGCCGCGCCCGAGAGCCCCTTCACCTGCAGGGCGACCCCAGCCGGCGACGCGTGA

ACCACGCCCTCAGCCGCCTTGCCAGCGCCCCCAGCCGCGCGCCCCAGCACCATGCGGCCG

CCCTGCGCACGGAGCCCCGAGGGACAGGGGCACCCGCAGGCCCGGCCCCTAGCACCGCCG

GCCGGCCCCGAGGTCCGGGACGCCGGCGCCGCCGCGGAGAGGGCACCGGGCCGACGCCTC

CCCCCAGGGTCAGCTGCGGGCTCCCAGGCCTAGGCGCCCATGACCCCTACGCCAACCGCC

GCCTGGACACCGCCGCCGCCACTGCGACCTAGCGCCGCCGCCGCCGGGGCCCAATGCCGG

TCATGCCCATTCCGCGGCGGGTGCGCTCCTTCCACGGCCCGCACACCACCTGCCTGCATG

CGGCCTGCGGGCCCGTGCGCGCCTCCCACCTGGCCCGCACCAAGTACAACAACTTCGACG

TGTACATCAAGACGCGCTGGCTGTACGGCTTCATCCGCTTCCTACTCTACTTTAGCTGCA

GCCTGTTCACTGCGGCGCTCTGGGGTGCGCTGGCCGCCCTCTTCTGCCTACAGTACCTGG

GCGTTCGCGTCCTGCTGCGCTTCCAGCGCAAGCTGTCGGTGCTGCTGCTGCTGCTGGGCC

GCCGGCGCGTGGACTTCCGCCTGGTGAACGAGCTGCTCGTCTATGGCATCCACGTCACCA

TGCTGCTGGTCGGGGGCCTGGGCTGGTGCTTCATGGTCTTCGTGGACATGTGAGGGCCGT

GGGTGCGAGCTTGATGTATCGTCCCGGCCTGTGGCTGTGTTCTCTCCATGGGTGGGGTCG

GCCAGCGCCTTCCCTTCGCCCATCCCCCAGGCAGTCGCTGCTGCCCGGCGCCCACGGAGA

GAAAAGAAAGGGCTGAGACTTCTGTGATGGGGGCGCGGACACCACCCCTAGGCTGGCTTC

CTGGACCCACCCTCCCCGTATGCACTCTCAGGGGCAGCGCCCACCTGCCGGTGGCTCCTG

CTCACATGTCTTCGGGTCGTACTGCGGGGTGGGCCCTCCGTTCCGCCTCTCTGTGGGCCT

CTCTCCAGGACCACAGCTGCCAGGGACTTTAGACATCACCCTGGGAGGCCCCTGGACACA

GAGGGCTGTGTGCCCAGGAGCAATTCCGGAGGGGGGCCCTCCTGGCTGCACAGCCCCTTC

TGCGTGCCCTGGCCCCAGCCCCAGCCAACGGGACACGGAAGGCTCCCCTCGCTGACACAC

CACACTGCCACAAAGCTGCTTACTCTGCCCTGGGCCGCCTGAGGCCTGGCACTGCCCGCG

GACCACCCTGTGTGTGTCATCCTGAGGGGCTGTGTGGGTCCTGAGTCCCCAGCCAGCCTT

CAGGGTCCCCTTGGATTGTGTAGATGCAGTCTAGCGGGGGGCCGGAGAAGGGCTCAGGTG

GGAGGGGCCTCAGCAGGCTCCCAGCTCAGGGGCTGGCCTGGGGGGAACCCTGGGAGCCAG

GGGCTGACTCCAGCAACACTGGCCTGTCTGCCTGTTCTGGGAGGGCTGTGAGGATGTCTT

GCAGATGCTCTGGATTTCTGCGGAGGCACCTCCATTCCTTTCTGGCTTTTTTTGCGGGGG

AGGGCTTTGGGCCTCTTTCTTTGAGGGAACACCGTCAAAGAAAGCCTGGGAGATCGAGGC

TTCAGTGAGCCAGGATGGAAACGCGTGTCCCAAGTGTCCGGAGCAGGCGGCAGAGGCCTC

AGTGCGGCAAACACAGCCCCAGAGCCTGTGTGGCACCAGCAGCATCTTAGAGCCCCAGGT

ATATGCTGAGATCTTATCTCACGCTGTCCTCCAGTGTCTGGGGGGCCCAAATGATGGCAC

AGGGTCAGGTGGGCTGGAGGGGCGCAGATGCCTGTGTTCAGGGAGGGTGGCCACCATGGG

CCGAGGTCTCACCCAGGACCCCTTGCTCTGCTCCTCAGCCTTGCAGTCACGGCAGCACTA

TGGTGGACTGCCCATGGCCGTGTGACTTTGGGGGCAAGTGGGAGGGCGCCCTGAATAATG

ATTGCAAGGACAACAGGCAGAGGCTACCCTAGAGCAGGACACAGGGTGTGGTACTGACAA

CCCTAGTGTCACCTCAAATCCATGTCCCCACACTCTGGGCATGGGTGGGACTTGTGACCC

TACCCTGTCAGGCGGACCAGTGGCCCAGGAGCCATGAGGACAGTTGTGTGCCACTGGAAG

AGAAACTTTTTGAAAAACCCTAAATCAGGTAGAGAAAGCAAAAAATCTCTGGCCGTAAAC

CGTGCTCTCTAATTTATCGGCAGCTTCTGTGGATGACCTCTGATGAGCCCGGGCTGCGTC

CACGCCCTGGGCAGGTAGGCGGGAGCTTCCCTGCGTGGGCCTCATTTCTTGCTGCAGAGA

ATCTTTTGCACTAAGTCATGCTGTTTCCTCAAAGAAGCTTTGTTTTTTGTTAACGTATTA

CTCAGAGTCACCCAAGCCTCTTGGCTGAGGGTGAAGGTGGGACGGGAGGCGGGAGGGGGC

TGGTGGTGCCGCTCGTGCGGTGTCAACGCTGCAGGGAGTTGTGGCACCTTGGTGCCCTCT

GAGCACCTGGCCGCCTGCTGTCCCCGGTGCCTGTGAAATTCGTCATGCCATGACCCACCT

GCATTAAACCTATTTTTTTAATGTGTTAAAAAAAAAAAAAAAAAA

>H09748
GNGGAAACACGGGCCAAACCCGTGANTTTGGTGCCCCTTGTAAACTCANCCCCTGCAAAN

CCAAAGACCCCAATGGATTTAAAGTTGNTTGGCATTTGTACTGGCAAGGCAAAANATTTT

TAANTACCTTTTCCTAATACTTATTGTATGAGCTTTTGNTGTTTACTTGGAGGTTTTGTC

TTTTACTACAAGTTTGGAACTATTTANTATTGCCTTGGTATTTGTGCTCTGTTTAAGAAA

CAGGCACTTTTTTTTATTATGGATAAAATGTTGAGATGACAGGAGGTCATTTCAATATGG

CTTAGTAAAATATTTATTGTTCCTTTATTCTCTGTACAAGATTTTGGGCCTCTTTTTTTC

CTTAATGTCACAATGTTGAGTTCAGCATGTGTCTGTCCATTTCATTTGTACGCTTGTTCA

AAACCAAGTTTGTTCTGGTTTCAAGTTATAAAAATAAATTGGACATTTAACTTGATCTCC

AAAAAAAAAAAAAAAA

>BC001665
GGCACGAGGCAATCTGAGGAGCAGGAGGACCGGGGCGCCGGTGTCCTGCCGCCTCCTTCT

CCTTGCTCTCACCTGCGCCTATTAGTCCACGCGCCTTCAAGGCCAGGGGCTACAGCCCAG

ACAGAGAGGGGACAGCAGAGGGAGAGAGAGCACCTGAGGATACAGAGCTGGCACTGGACT

GCCTTTTCACCCCCCAGGTGATGAGTGAGGTTCGAAGAACGGAAGATTTAAAAAGCAGCC

GGGGCCTCCGTATTGAATGAAAGACCCAGTGCAAAGACATCACCATGAACACTAGCATTC

CTTATCAGCAGAATCCTTACAATCCACGGGGCAGCTCCAATGTCATCCAGTGCTACCGCT

GTGGAGACACCTGCAAAGGGGAAGTGGTCCGCGTGCACAACAACCACTTCCACATCAGAT

GCTTCACCTGTCAAGTATGTGGCTGTGGCCTGGCCCAGTCAGGCTTCTTCTTCAAGAACC

AGGAGTACATCTGCACCCAGGACTACCAGCAACTCTATGGCACCCGCTGTGACAGCTGCC

GGGACTTCATCACAGGCGAAGTCATCTCGGCCCTGGGCCGCACTTACCACCCCAAGTGCT

TCGTGTGCAGCTTGTGCAGGAAGCCTTTCCCCATTGGAGACAAGGTGACCTTCAGCGGTA

AAGAATGTGTGTGCCAAACGTGCTCCCAGTCCATGGCCAGCAGTAAGCCCATCAAGATTC

GTGGACCAAGCCACTGTGCCGGGTGCAAGGAGGAGATCAAGCACGGCCAGTCACTCCTGG

CTCTGGACAAGCAGTGGCACGTCAGCTGCTTCAAGTGCCAGACCTGCAGCGTCATCCTCA

CCGGGGAGTATATCAGCAAGGATGGTGTTCCATACTGTGAGTCCGACTACCATGCCCAGT

TTGGCATTAAATGTGAGACTTGTGACCGATACATCAGTGGCAGAGTCTTGGAGGCAGGAG

GGAAGCACTACCACCCAACCTGTGCCAGGTGTGTACGCTGCCACCAGATGTTCACCGAAG

GAGAGGAAATGTACCTCACAGGTTCCGAGGTTTGGCACCCCATCTGCAAACAGGCAGCCC

GGGCAGAGAAGAAGTTAAAGCATAGACGGACATCTGAAACCTCCATCTCACCCCCTGGAT

CCAGCATTGGGTCACCCAACCGAGTCATCTGCGACATCTACGAGAACCTGGACCTCCGGC

AGAGACGGGCCTCCAGCCCGGGGTACATAGACTCCCCCACCTACAGCCGGCAGGGCATGT

CCCCCACCTTCTCCCGCTCACCTCACCACTACTACCGCTCTGGTGATTTGTCTACAGCAA

CCAAGAGCAAAACAAGTGAAGACATCAGCCAGACCTCCAAGTACAGTCCCATCTACTCGC

CAGACCCCTACTATGCTTCGGAGTCTGAGTACTGGACCTACCATGGGTCCCCCAAAGTGC

CCCGAGCCAGAAGGTTCTCGTCTGGAGGAGAGGAGGATGATTTTGACCGCAGCATGCACA

AGCTCCAAAGTGGAATTGGCCGGCTGATTCTGAAGGAAGAAATGAAGGCCCGGTCGAGCT

CCTATGCAGATCCCTGGACCCCTCCCCGGAGCTCCACCAGCAGCCGGGAAGCCCTGCACA

CAGCTGGCTATGAGATGTCCCTCAATGGCTCCCCTCGGTCGCACTACCTGGCTGACAGTG

ATCCTCTCATCTCCAAATCTGCCTCCCTGCCTGCCTACCGAAGAAATGGGCTGCACAGGA

CACCCAGCGCAGACCTCTTCCACTACGACAGCATGAACGCAGTCAACTGGGGCATGCGAG

AGTACAAGATCTACCCTTATGAACTGCTGCTGGTGACTACAAGAGGAAGAAACCGACTGC

CCAAGGATGTAGACAGGACCCGTTTAGAGGGAAACTTTTGGAAGAGTGGCTGCTTATGAG

ATTCCAAAATGAAGTGTTGGCCAACACCGCTCATGGCCATCCTGGATTTTCCCAGTGGCT

TCCCTTCCTGCTCGCCTCCCTGAACAGGGGAGAAAGCTTAACCTCTCTTCTCCTCTCCAA

ACCTTTCACCTTGAATGGGTAATGTTTGGTGGGGGCTGTTCCTTCTTGGAGAAGCCTTGA

GTCGGACCATTTTGAGATCATGGAGGAAGGATGAAGAAGTGAAAATGACAATAATGACTC

TCAAGAGGCTGGCGATGTGACATGGCAAATGTAGAACTGACTTAAATTGAACAAACCCTC

ACTGAGCACCTCTGATGTTGAGCACCTGCTGAATACTGAGCACTGAATGGGGGAGGGGGA

GGGGAGCACGGGGTGAGTCAACCTGGGACTCGGTCTCAGGGATATGCCTACCAATAGCGG

GTATCGTAAGGCATGTACCCAAACATAACGGATGTAAGGCAGAAAGTGATCGGAGAAGGA

ATGAGAAAGTGTGCGTGATGTTAATGAAAAGTCATATGCAGCTAGAGCAGACCCAGGAAA

GCTTTCTGGAAGAGATTGCATCTGAGGAAATTCAGGAAGGATCTTTGTAGATTGGGGGGA

GATTCTAAATTGAAGGGGTGATGGGGTGAGGGGCCAGAGGGAAGTCTGCTGTGTTCTCAT

GTAGGATGTCAGCCCTCCCTGCAACTTCTCTTTTTGGCCAATGTCTTTTCACTTTCCTGA

CCCTTTAGAATCATCCCCAGCCAGACGCAATCATGGAAGTTGCCTTATTGTCACTGGTTA

AGAACTTGGCGAGATTGAAGGGCTTTTGTTATTGTTGTTGGATATTTTTGTTTCCCATAA

AAGCACATCATTTCAACCCTAAAAAAAAAAAAAAAAAAAAAA

>BC016451
GAAGAATTAGATACTTTTGAGTGGGCTTTGAAGAGCTGGTCTCAGTGTTCCAAACCCTGT

GGTGGAGGTTTCCAGTACACTAAATATGGATGCCGTAGGAAAAGTGATAATAAAATGGTC

CATCGCAGCTTCTGTGAGGCCAACAAAAAGCCGAAACCTATTAGACGAATGTGCAATATT

CAAGAGTGTACACATCCACTCTGGGTAGCAGAAGAATGGGAACACTGCACCAAAACCTGT

GGAAGTTCTGGCTATCAGCTTCGCACTGTACGCTGCCTTCAGCCACTCCTTGATGGCACC

AACCGCTCTGTGCACAGCAAATACTGCATGGGTGACCGTCCCGAGAGCCGCCGGCCCTGT

AACAGAGTGCCCTGCCCTGCACAGTGGAAAACAGGACCCTGGAGTGAGTGTTCAGTGACC

TGCGGTGAAGGAACGGAGGTGAGGCAGGTCCTCTGCAGGGCTGGGGACCACTGTGATGGT

GAAAAGCCTGAGTCGGTCAGAGCCTGTCAACTGCCTCCTTGTAATGATGAACCATGTTTG

GGAGACAAGTCCATATTCTGTCAAATGGAAGTGTTGGCACGATACTGCTCCATACCAGGT

TATAACAAGTTATGTTGTGAGTCCTGCAGCAAGCGCAGTAGCACCCTGCCACCACCATAC

CTTCTAGAAGCTGCTGAAACTCATGATGATGTCATCTCTAACCCTAGTGACCTCCCTAGA

TCTCTAGTGATGCCTACATCTTTGGTTCCTTATCATTCAGAGACCCCTGCAAAGAAGATG

TCTTTGAGTAGCATCTCTTCAGTGGGAGGTCCAAATGCATATGCTGCTTTCAGGCCAAAC

AGTAAACCTGATGGTGCTAATTTACGCCAGAGGAGTGCTCAGCAAGCAGGAAGTAAGACT

GTGAGACTGGTCACCGTACCATCCTCCCCACCCACCAAGAGGGTCCACCTCAGTTCAGCT

TCACAAATGGCTGCTGCTTCCTTCTTTGCAGCCAGTGATTCAATAGGTGCTTCTTCTCAG

GCAAGAACCTCAAAGAAAGATGGAAAGATCATTGACAACAGACGTCCGACAAGATCATCC

ACCTTAGAAAGATGAGAAAGTGAACCAAAAAGGCTAGAAACCAGAGGAAAACCTGGACAA

CCTCTCTCTTCCCATGGTGCATATGCTTGTTTAAAGTGGAAATCTCTATAGATCGTCAGC

TCATTTTATCTGTAATTGGAAGAACAGAAAGTGCTGGCTCACTTTCTAGTTGCTTTCATC

CTCCTTTTGTTCTGCATTGACTCATTTACCAGAATTCATTGGAAGAAATCACCAAAGATT

ATTACAAAAGAAAAATATGTTGCTAAGATTGTGTTGGTCGCTCTCTGAAGCAGAAAAGGG

ACTGGAACCAATTGTGCATATCAGCTGACTTTTTGTTTGTTTTAGAAAAGTTACAGTAAA

AATTAAAAAGAGATACCAATGGTTTACACTTTAACAAGAAATTTTGGATATGGAACAAAG

AATTCTTAGACTTGTATTCCTATTTATCTATATTAGAAATATTGTATGAGCAAATTTGCA

GCTGTTGTGTAAATACTGTATATTGCAAAAATCAGTATTATTTTAAGAGATGTGTTCTCA

AATGATTGTTTACTATATTACATTTCTGGATGTTCTAGGTGCCTGTCGTTGAGTATTGCC

TTGTTTGACATTCTATAGGTTAATTTTCAAAGCAGAGTATTACAAAAGAGAAGTTAGAAT

TACAGCTACTGACAATATAAAGGGTTTTGTTGAATCAACAATGTGATACGTAAATTATAG

AAAAAGAAAAGAAACACAAAAGCTATAGATATACAGATATCAGCTTACCTATTGCCTTCT

ATACTTATAATTTAAAGGATTGGTGTCTTAGTACACTTGTGGTCACAGGGATCAACGAAT

AGTAAATAATGAACTCGTGCAAGACAAAACTGAAACCCTCTTTCCAGGACCTCAGTAGGC

ACCGTTGAGGTGTCCTTTGTTTTTGTGTGTGTGTGTTCTTTTTTAATTTTCGCATTGTTG

ACAGATACAAACAGTTATACTCAATGTACTGTAATAATCGCAAAGGAAAAAGTTTTGGGA

TAACTTATTTGTATGTTGGTAGCTGAGAAAAATATCATCAGTCTAGAATTGATATTTGAG

TATAGTAGAGCTTTGGGGCTTTGAAGGCAGGTTCAAGAAAGCATATGTCGATGGTTGAGA

TATTTATTTTCCATATGGTTCATGTTCAAATGTTCACAACCACAATGCATCTGACTGCAA

TAATGTGCTAATAATTTATGTCAGTAGTCACCTTGCTCACAGCAAAGCCAGAAATGCTCT

CTCCAGGGAGTAGATGTAAAGTACTTGTACATAGAATTCAGAACTGAAGATATTTATTAA

AAGTTGATTTTTTTTTCTTGATAGTATTTTTATGTACTAAATATTTACACTAATATCAAT

TACATATTTTGGTAAACTAGAGAGACATAATTAGAGATGCATGCTTTGTTCTGTGCATAG

AGACCTTTAAGCAAACTACTACAGCCAACTCAAAAGCTAAAACTGAACAAATTTGATGTT

ATGCAAACATCTTGCATTTTTAGTAGTTGATATTAAGTTGATGACTTGTTTCCCTTCAAG

GAAACATTAAATTGTATGGACTCAGCTAGCTGTTCAATGAAATTGTGAATTAGAAACATT

TTTAAAAGTTTTTGAAAGAGATAAGTGCATCATGAATTACATGTACATGAGAGGAGATAG

TGATATCAGCATAATGATTTTGAGGTCAGTACCTGAGCTGTCTAAAAATATATTATACAA

ACTAAAATGTAGATGAATTAACCTCTCAAAGCACAGAATGTGCAAGAACTTTTGCATTTT

AATCGTTGTAAACTAACAGCTTAAACTATTGACTCTATACCTCTAAAGAATTGCTGCTAC

TTTGTGCAAGAACTTTGAAGGTCAAATTAGGCAAATTCCAGATAGTAAAACAATCCCTAA

GCCTTAAGTCTTTTTTTTTTTCCTAAAAATTCCCATAGAATAAAATTCTCTCTAGTTTAC

TTGTGTGTGCATACATCTCATCCACAGGGGAAGATAAAGATGGTCACACAAACAGTTTCC

ATAAAGATGTACATATTCATTATACTTCTGACCTTTGGGCTTTCTTTTCTACTAAGCTAA

AAATTCCTTTTTATCAAAGTGTACACTACTGATGCTGTTTGTTGTACTGAGAGCACGTAC

CAATAAAAATGTTAACAAAATATAAAAAAAAAAAAAAA

>BF510316
TCCTGTGTTCTAGACCTCTGGAGGCTGCTGTGGGGACCACACTGATCCTGGAGAAAAGGG

ATGGAGCTGAAAAAGATGGAATGCTTGCAGAGCATGACCTGAGGAGGGAGGAACGTGGTC

AACTCACACCTGCCTCTTCCTGCAGCCTCACCTCTACCTGCCCCCATCATAAGGGCACTG

AGCCCTTCCCAGGCTGGATACTAAGCACAAAGCCCATAGCACTGGGCTCTGATGGCTGCT

CCACTGGGTTACAGAATCACAGCCCTCATGATCATTCTCAGTGAGGGCTCTGGATTGAGA

GGGAGGCCCTGGGAGGAGAGAAGGGGGCAGAGTCTTCCCTACCAGGTTTCTACACCCCCG

CCAGGCTGCCCATCAGGGCCCAGGGAGCCCCCAGAGGACTTTATTCGGACCAAGCAGAGC

TCACAGCTGGACAGGTGTTGTATATAGAGTGGAATCTCTTGGATGCAGCTTCAAGAATAA

ATTTTTCTTCTCTTTTCAAAAATGTATAAAAATCATTATACATAGCATTAAAGAAACATT

TTTGAGAAGTACAAAACAAAAAAAAAA

>AF301598
CGGGCGCCGCAGGAGCGAGTGAGCTGGGAGCGAGGGGCGAAGGCGCGGAGAAGCCCGGCC

GCCCGGTGGGCGGCAGAAGGCTCAGCCGAGGCGGCGGCGCCGACTCCGTTCCACTCTCGG

CCCGGATCCAGGCCTCCGGGTTCCCAGGCGCTCACCTCCCTCTGACGCACTTTAAAGAGT

CTCCCCCCTTCCACCTCAGGGCGAGTAATAGCGACCAATCATCAAGCCATTTACCAGGCT

TCGGAGGAAGCTGTTTATGTGATCCCCGCACTAATTAGGCTCATGAACTAACAAATCGTT

TGCACAACTTGTGAAGAAGCGAACACTTCCATGGATTGTCCTTGGACTTAGGGCGCCCTG

CCCGCCTTTTGCAGAGGAGAAAAAACTTTTTTTTTTTTTTGCCTCCCCCGAGAACTTTCC

CCCCTTCTCCTCCCTGCCTCTAACTCCGATCCCCCCACGCCATCTCGCCAAAAAAAAAAA

AAAAAAAAAAAAAGAAAAAAAAAGAAAAAAAAAGAAAAAAAATTACCCCAATCCACGCCT

GCAAATTCTTCTGGAAGGATTTTCCCCCCTCTCTTCAGGTTGGGCGCGTTTGGTGCAAGA

TTCTCGGGATCCTCGGCTTTGCCTCTCCCTCTCCCTCCCCCCTCCTTTCCTTTTTCCTTT

CCTTTCCTTTCTTTCTTCCTTTCCTTCCCCCCACCCCCACCCCCACCCCAAACAAACGAG

TCCCCAATTCTCGTCCGTCCTCGCCGCGGGCAGCGGGCGGCGGAGGCAGCGTGCGGCGGT

CGCCAGGAGCTGGGAGCCCAGGGCGCCCGCTCCTCGGCGCAGCATGTTCCAGCCGGCGCC

CAAGCGCTGCTTCACCATCGAGTCGCTGGTGGCCAAGGACAGTCCCCTGCCCGCCTCGCG

CTCCGAGGACCCCATCCGTCCCGCGGCACTCAGCTACGCTAACTCCAGCCCCATAAATCC

GTTCCTCAACGGCTTCCACTCGGCCGCCGCCGCCGCCGCCGGTAGGGGCGTCTACTCCAA

CCCGGACTTGGTGTTCGCCGAGGCGGTCTCGCACCCGCCCAACCCCGCCGTGCCAGTGCA

CCCGGTGCCGCCGCCGCACGCCCTGGCCGCCCACCCCCTACCCTCCTCGCACTCGCCACA

CCCCCTATTCGCCTCGCAGCAGCGGGATCCGTCCACCTTCTACCCCTGGCTCATCCACCG

CTACCGATATCTGGGTCATCGCTTCCAAGGGAACGACACTAGCCCCGAGAGTTTCCTTTT

GCACAACGCGCTGGCCCGAAAGCCCAAGCGGATCCGAACCGCCTTCTCCCCGTCCCAGCT

TCTAAGGCTGGAACACGCCTTTGAGAAGAATCACTACGTGGTGGGCGCCGAAAGGAAGCA

GCTGGCACACAGCCTCAGCCTCACGGAAACTCAGGTAAAAGTATGGTTTCAGAACCGAAG

AACAAAGTTCAAAAGGCAGAAGCTGGAGGAAGAAGGCTCAGATTCGCAACAAAAGAAAAA

AGGGACGCACCATATTAACCGGTGGAGAATCGCCACCAAGCAGGCGAGTCCGGAGGAAAT

AGACGTGACCTCAGATGATTAAAAACATAAACCTAACCCCACAGAAACGGACAACATGGA

GCAAAAGAGACAGGGAGAGGTGGAGAAGGAAAAAACCCTACAAAACAAAAACAAACCGCA

TACACGTTCACCGAGAAAGGGAGAGGGAATCGGAGGGAGCAGCGGAATGCGGCGAAGACT

CTGGACAGCGAGGGCACAGGGTCCCAAACCGAGGCCGCGCCAAGATGGCAGAGGATGGAG

GCTCCTTCATCAACAAGCGACCCTCGTCTAAAGAGGCAGCTGAGTGAGAGACACAGAGAG

AAGGAGAAAGAGGGAGGGAGAGAGAGAAAGAGAGAGAAAGAGAGAGAGAGAGAGAGAGAG

AGAAAGCTGAACGTGCACTCTGACAAGGGGAGCTGTCAATCAAACACCAAACCGGGGAGA

CAAGATGATTGGCAGGTATTCCGTTTATCACAGTCCACTTAAAAAATGATGATGATGATA

AAAACCACGACCCAACCAGGCACAGGACTTTTTTGTTTTTTGCACTTCGCTGTGTTTCCC

CCCCATCTTTAAAAATAATTAGTAATAAAAAACAAAAATTCCATATCTAGCCCCATCCCA

CACCTGTTTCAAATCCTTGAAATGCATGTAGCAGTTGTTGGGCGAATGGTGTTTAAAGAC

CGAAAATGAATTGTAATTTTCTTTTCCTTTTAAAGACAGGTTCTGTGTGCTTTTTATTTT

GATTTTTTTTCCCAAGAAATGTGCAGTCTGTAAACACTTTTTGATACCTTCTGATGTCAA

AGTGATTGTGCAAGCTAAATGAAGTAGGCTCAGCGATAGTGGTCCTCTTACAGAGAAACG

GGGAGCAGGACGACGGGGGGGCTGGGGGTGGCGGGGGAGGGTGCCCACAAAAAGAATCAG

GACTTGTACTGGGAAAAAAACCCCTAAATTAATTATATTTCTTGGACATTCCCTTTCCTA

ACATCCTGAGGCTTAAAACCCTGATGCAAACTTCTCCTTTCAGTGGTTGGAGAAATTGGC

CGAGTTCAACCATTCACTGCAATGCCTATTCCAAACTTTAAATCTATCTATTGCAAAACC

TGAAGGACTGTAGTTAGCGGGGATGATGTTAAGTGTGGCCAAGCGCACGGCGGCAAGTTT

TCAAGCACTGAGTTTCTATTCCAAGATCATAGACTTACTAAAGAGAGTGACAAATGCTTC

CTTAATGTCTTCTATACCAGAATGTAAATATTTTTGTGTTTTGTGTTAATTTGTTAGAAT

TCTAACACACTATATACTTCCAAGAAGTATGTCAATGTCAATATTTTGTCAATAAAGATT

TATCAATATGCCAAAAAAAAAAAAAAA

>Hs.77031_mRNA_1 gi\|16741772\|gb\|BC016680.1\|BC016680 Homo sapiens clone
MGC:21349 IMAGE:4338754 polyA = 3
GTGGCGGCGGAGGCGGCGGAGGCCAGGGAGGAAGATGTCGTAATGAGCGATCCACAGACC

AGCATGGCTGCCACTGCTGCTGTGAGTCCCAGTGACTACCTGCAGCCTGCCGCCTCCACC

ACCCAGGACTCCCAGCCATCTCCCTTAGCCCTGCTTGCTGCAACATGTAGCAAAATTGGC

CCTCCAGCAGTTGAAGCTGCTGTGACACCTCCTGCTCCCCCACAGCCCACACCGCGGAAA

CTTGTCCCTATCAAACCTGCCCCTCTCCCTCTCAGCCCCGGCAAGAATAGCTTTGGAATC

TTGTCCTCCAAAGGAAATATACTTCAGATTCAGGGGTCACAACTGAGCGCCTCCTATCCT

GGAGGGCAGCTGGTGTTCGCTATCCAGAATCCCACCATGATCAACAAAGGGACCCGATCA

AATGCCAATATCCAGTACCAGGCGGTCCCTCAGATTCAGGCAAGCAATTCCCAAACCATC

CAAGTACAGCCCAATCTCACCAACCAGATCCAGATCATCCCTGGCACCAACCAAGCCATC

ATCACCCCCTCACCGTCCAGTCACAAGCCTGTCCCCATCAAGCCAGCCCCCATCCAGAAG

TCGAGTACGACCACCACCCCCGTGCAGAGCGGGGCCAATGTGGTGAAGTTGACAGGTGGG

GGCGGCAATGTGACGCTCACTCTGCCCGTCAACAACCTCGTGAACGCCAGTGACACCGGG

GCCCCTACTCAGCTCCTCACTGAAAGCCCCCCAACCCCGCTGTCTAAGACTAACAAGAAA

GCAAGGAAGAAGAGCCTTCCTGCCTCCCAGCCCCCTGTGGCTGTGGCTGAGCAGGTGGAG

ACGGTGCTGATCGAGACCACCGCGGACAACATCATCCAGGCAGGAAATAACCTGCTCATT

GTTCAGAGCCCTGGTGGGGGCCAGCCAGCTGTGGTCCAGCAGGTCCAGGTGGTGCCCCCC

AAGGCCGAGCAGCAGCAGGTGGTACAGATCCCCCAGCAGGCTCTGCGGGTGGTGCAGGCG

GCATCTGCCACCCTCCCCACTGTACCCCAGAAGCCCTCCCAGAACTTTCAGATCCAGGCA

GCTGAGCCGACACCTACTCAGGTCTACATCCGCACGCCTTCCGGTGAGGTGCAGACAGTC

CTTGTCCAGGACAGCCCCCCAGCAACAGCTGCAGCCACCTCTAACACCACCTGTAGCAGC

CCTGCATCCCGTGCTCCCCATCTGAGTGGGACCAGCAAAAAGCACTCAGCTGCAATTCTC

CGAAAAGAGCGTCCCCTGCCAAAGATTGCCCCAGCCGGGAGCATCATCAGCCTGAATGCA

GCCCAGTTGGCGGCAGCTGCCCAGGCAATGCAGACCATCAACATCAATGGTGTCCAGGTC

CAGGGCGTGCCTGTCACCATCACCAACACAGGCGGGCAGCAGCAGCTGACAGTGCAGAAT

GTTTCTGGGAACAACCTGACCATCAGTGGGCTGAGCCCCACCCAGATCCAGCTGCAAATG

GAACAAGCCCTGGCCGGAGAGACCCAGCCCGGGGAGAAGCGGCGCCGCATGGCCTGCACG

TGTCCCAACTGCAAGGATGGGGAGAAGAGGTCTGGAGAGCAGGGCAAGAAGAAGCACGTG

TGCCACATCCCCGACTGTGGCAAGACGTTCCGTAAGACGTCCTTGCTGCGTGCCCATGTG

CGCCTGCACACTGGCGAGCGGCCCTTTGTCTGCAACTGGTTCTTCTGTGGGAAGAGGTTC

ACACGGAGTGACGAGCTCCAACGGCATGCTCGCACCCACACAGGGGACAAACGCTTCGAG

TGCGCCCAGTGTCAGAAGCGCTTCATGAGGAGTGACCACCTCACCAAGCATTACAAGACC

CACCTGGTCACGAAGAACTTGTAAGGCCAACTGCGGCGGGAGGCCCTGAAGATGCAGTCC

CCCACCTGTGTCCTCCCTGGGCCCCTGGTGGAAAGGAGCCCTGTGGCTGCCTTGGGCCTG

CCCTCAGCCCCACTCCTGTTCTGCAACTGTCCCCACAGGAAGGGGCTCTGTTCCCTGTAT

TGTCCTCCTTCTGAAGCCCCTTGGCTCTGCCTTGGCCCTTCCCCTCACCACGAGCTCCCG

GCCTGCCCAGACTGTGGACACTGGCCGTGCCCAATGAGACGTTCTAAACCAGGACGCGTG

GGAACCCTTATTTCCAAAGGAAAAACATGCATTTCACTCCGTCGAGGAGCAAAGTGAGCC

CCTACCCCCCACCCCGATCCCCGCTCCCAACACTGCCGGAGTCGCGTCATGCCATGCCCC

CTCTCCTGCACCTCCCTGGCCCTGCCGGCCACTGTGGACGCCCTGGGGCTTGGCACCCAC

CTCTGGAGAAACTCGGGGCCACCTCCACTCCATGTGCCCAGCCCCGCCACAACCTCTCCT

CCAGCACATTCCAGCTCTATTTAAAAAGTAAAGACACCCACCGACTCCTGATCCCCCTCT

TTTTCTATGGAGAACGTTGCCTTATACTCTCTACTTCAGATGATGAACACTGTGTACTGT

GTGTGCTTTAAAGAAGTTTTATTTAATTGCTCCCTTCTTCCTTTCCTTGTTATTCACCTC

CCTGATGCCTGCTTTCAGTTGAGGGTTGGGGGCAATGATGAGCATATGAATTTTTTCTCA

CTCTAGCAATTCCCTTTTCTAAATGACACAGCATTTAAACTCAAATCTGGATTCAGATAA

CAGCACCTGCACATCCTGCACCTCCTCCCTCTCCCTTCACCTCACCCCTGCCCGGCCCAA

GCTCTACTTGTGTACAGTGTATATTGTATAATAGACAATTGTGTCTACTACATGTTTAAA

AACACATTGCTTGTTATTTTTGAGGCTTTTAAATTAAACAAAAATCCAACTTTAAAAAAA

AAAAAAAA

>Hs.77541_mRNA_1 gi\|12804364\|gb\|BC003043.1\|BC003043 Homo sapiens clone
MGC:4370 IMAGE:2822973 polyA = 3
CCCGCGTCGGTGCCCGCGCCCCTCCCCGGGCCCCGCCATGGGCCTCACCGTGTCCGCGCT

CTTTTCGCGGATCTTCGGGAAGAAGCAGATGCGGATTCTCATGGTTGGCTTGGATGCGGC

TGGCAAGACCACAATCCTGTACAAACTGAAGTTGGGGGAGATTGTCACCACCATCCCAAC

CATAGGCTTCAATGTAGAAACAGTGGAATATAAGAACATCTGTTTCACAGTCTGGGACGT

GGGAGGCCAGGACAAGATTCGGCCTCTGTGGCGGCACTACTTCCAGAACACTCAGGGCCT

CATCTTTGTGGTGGACAGTAATGACCGGGAGCGGGTCCAAGAATCTGCTGATGAACTCCA

GAAGATGCTGCAGGAGGACGAGCTGCGGGATGCAGTGCTGCTGGTATTTGCCAACAAGCA

GGACATGCCCAACGCCATGCCCGTGAGCGAGCTGACTGACAAGCTGGGGCTACAGCACTT

ACGCAGCCGCACGTGGTATGTCCAGGCCACCTGTGCCACCCAAGGCACAGGTCTGTACGA

TGGTCTGGACTGGCTGTCCCACGAGCTGTCAAAGCGCTAACCAGCCAGGGGCAGGCCCCT

GATGCCCGGAAGCTCCTGCGTGCATCCCCGGATGACCATACTCCCGGACTCCTCAGGCAG

TGCCCTTTCCTCCCACTTTTCCTCCCCCATAGCCACAGGCCTCTGCTCCTGCTCCTGCCT

GCATGTTCTCTCTGTTGTTGGAGCCTGGAGCCTTGCTCTCTGGGCACAGAGGGGTCCACT

CTCCTGCCTGCTGGGACCTATGGAAGGGGCTTCCTGGCCAAGGCCCCCTCTTCCAGAGGA

GGAGCAGGGATCTGGGTTTCCTTTTTTTTTTCTGTTTTGGGTGTACTCTAGGGGCCAGGT

TGGGAGGGGGAAGGTGAGGGCTTCGGGTGGTGCTATAATGTGGCACTGGATCTTGAGTAA

TAAATTTGCTGTGGTTTGAAAAAAAAAAAAAAAAAAAAA

>Hs.7001_mRNA_1 gi\|6808256 emb\|AL137727.1\|HSM802274 Homo sapiens mRNA; cDNA
DKFZp434M0519 (from clone DKFZp434M0519); partial cds polyA = 3
GTGGCGGTGGCTGCGGCGACGGCAGAGGCGAAGGGAGCCGGATCGCCGACCTGAGCGGGA

GGCGGCGGTGGCGGCCATGGCGGCAGATGGAGAGCGTTCCCCGCTGCTGTCTGAGCCCAT

CGACGGTGGCGCGGGCGGCAACGGTTTAGTGGGGCCCGGCGGGAGTGGGGCTGGGCCCGG

GGGAGGCCTGACCCCCTCCGCACCACCGTACGGAGCCGGTAAACATGCCCCGCCCCAGGG

TAAGCCGGGGCGGGTCCGAGGTGCTCCCCGGGGTACTCTGAAAGCCGGGGAGGGGGCGGG

ACCGAGGGCGGAGGCGGGTCCCAGTCGCCAGGTGCGGGACTGCTGCACCTGTGACTGGGC

GAGGCTTCCTTCCCTCCGTAATCGCGACCACAGCCTAGGGACGGAAGGGGGTTCTGAGCA

ACCTGATAGAAGTGCCAATTATGAGAAGCCCTCCGAGCTTGGTCAGAGGGTTGAAGATCA

GAAGGACTTCCCTACCACCGTGGAGCATCAGTGGGGGTGTAAGTGATCCCAGCCCTTCTA

TTTGCTTCCTCTCCAGCATTTCCCCCGTTTCCCGAGGGGCATCCAGCCGTGTTGCCTGGG

GAGGACCCACCCCCCTATTCACCCTTAACTAGCCCGGACAGTGGGAGTGCCCCTATGATC

ACCTGCCGAGTCTGCCAATCTCTCATCAACGTGGAAGGCAAGATGCATCAGCATGTAGTC

AAATGTGGTGTCTGCAATGAAGCCACCGTGAGTTACACATATCTATGAAATGGGCCCTGT

TTCCTGGATCCTCTTTCTGATGTCTTGGTTCTAGACCCTGACCTTCCGGCTATTAGCCAA

GTGCTTTTGATGATACCCAGGTTTCAGTTCCAGGTGTCTCACACAGCCATTTCCCCAGAA

GCCACTCACCAAAGCTAATGTTCACTTTCTCTCACTTTTACACCTAGCCTAGTTCCTATT

TGCAAATCTCATGATATAGTCTTTCTTTTATTTCTCCTTCCTGGTTAGCACCTTATTTTT

CTGATCTCATAAAGTGTTTTTGGAGGGAAGTGGAGGGGATTGGGATTAGAGGTTTGCTTG

CTGATGACCCTATTATTCTCTAGCCAATCAAGAATGCACCCCCAGGGAAAAAATATGTTC

GATGCCCCTGTAACTGTCTCCTTATCTGCAAAGTGACATCCCAACGGATTGCATGCCCTC

GTCCCTACTGGTAAGAGGCATAAGGTGGGGAAGGGCCTAAGTGGGGAACTGGAAAGTCAA

AAAAGGATGAGCGTATACAGAGAATGTAAAGGTGAGAGAGCCTAGTGTTTATTTAGGAGA

AAAGGCTTTGAAGCATGTGCCTCAGGAATGTTATAGCTGTCTTTCTCGTTTCTCAATAAA

AATATTGAGATGAAATGATGTCGTTTCGGAGAATAGAGAGCCTTGGGGACTGGGTGTGTT

ATCCTGAGGTCGGAGGGGAATTGGGGACCTGAAGTTTAAACAGTGCTCTTTCTTTCTCAA

GGATTCTTGAGGGTATACAGTTGGGGGACAGAGTATCTTAAGTACAGAGAAGTCGAGTGA

CTTAATAGACAGGGAGTGGGGGATGTGGAACAGGGACTGTGAAGATTTTTAGGATTAAAA

ATTTTTCAAACACAAGTTTGAAAATACAAGTCTTTTTCTTTTGTATAGCAAAAGAATCAT

CAACCTGGGGCCTGTGCATCCCGGACCTCTGAGTCCAGAACCCCAACCCATGGGTGTCAG

GGTTATCTGTGGACATTGCAAGAATACTTTTCTGGTGAGGAAGGGGTATTGGGAAGGGGA

GGGGAAAGGAGACTAAGAGTCATTTCGAGTATATTTCTTAGAGTAATGGTAATGACCCCT

GAAAGGTCTGTCCTATGGGAACATGTTCTGCATCCCCACCCCAAGGTTCTCATTGAGGGA

GACCCTGCTTGTGCTATTATTTTTGTTTTCTTTCTCCATAGTGGACAGAGTTCACAGACC

GCACTTTGGCACGTTGTCCTCACTGCAGGAAAGTGTCATCTATTGGGCGCAGATACCCAC

GTAAGAGATGTATCTGCTGCTTCTTGCTTGGCTTGCTTTTGGCAGTCACTGCCACTGGCC

TTGCCGTGAGTACCCTTGCCCCAACCTCTTTCATTCTGCAGCCTCATCTCCATAGGCTAA

GATTTGGGAAACTGCTACCCTAAAAAAAAGTGGAAGAAACTTAGGGGACTAGTTTGTTTT

GTTTTAAGATATGGATGAGCTAAAGTGCAAAGTGGCTGATCAAACAGACTTTATTACTAC

TACAAGAGTGAAAAACAGCCTTCCTTTCTCTGTAGGATGAGGATAGGACAGTGAAATTCT

TAATTTAAGAGTTGCTATTTTTCAAACCTGGCTCAGTTGTCAGATATTAAGAAAAACTGA

GATACAGTGTGGGATGGGATGAGTATGTTACGCCTAAGGGAAGGAAGCTGATCAGCTCTG

CCTTTAAGAAGGTCCCTGAGGGTGGCTACATGTGGATAAGGAACAAGGACTGAAGCGTGA

GTTATTACTGTTCTTAGAACTAATAGGAGGTAGTGGAGACCAACATTAACCCCATCTTTC

TTTTCTTCTCCCTCCTTATCTTCATCAGTTTGGCACATGGAAGCATGCACGGCGATATGG

AGGCATCTATGCAGCCTGGGCATTTGTCATCCTGTTGGCTGTGCTGTGTTTGGGCCGGGC

TCTTTATTGGGCCTGTATGAAGGTCAGCCACCCTGTCCAGAACTTCTCCTGAGCCTGATG

ACCCACAGACTGTGCCTGGCCCCTCCCTGGTGGGGACAGTGACACTACGAAGGGAGCTGG

GGTAGTTAAAGGCTCCCGGGGCTTCTAGAAGGAAGCCAAGCAGCTGCCTTCCTTTTCCCT

GGGGAGAGGTAGGAAGGAACCAGGCCCTCACTTAGGTTTGGAGGGGCAGATAAGAGCACT

GCTGACCATCTGCTTTCCTCCAAGGGTTGCTGTGTCTAGGGTGAAGTAGGCAAAACGTTG

CCCTTAAAACTGGGCCCTGAAGACGGTTCCAGCCTTGTCCTTCCTGTGTGCTCCCTGAGA

GCCATTCCTGTCCCTTACACATTCCAGGGCAGGGTGGGGGTGGGTAGCCCTGGGGGTTCC

CCTCCCTCTTGTGCACCATTAGGACTTTGCTGCTGCTATTGCACTTCACCAGAGGTTGGC

TCTGGCCTCAGTACCCTCAGTCTCCTCTCCCCACATTGTGTCCTGTGGGGGTGGGGTCAG

CCGCTGCTCTGTACAGAACCACAGGAACTGATGTGTATATAACTATTTAATGTGGGATAT

GTTCCCCTATTCCTGTATTTCCCTTAATTCCTCCTCCCGACCTTTTTTACCCCCCCAGTT

GCAGTATTTAACTGGGCTGGGTAGGGTTGCTCAGTCTTTGGGGGAGGTTAGGGACTTATC

CTGTGCTTGTAAATAAATAAGGTCATGACTCTAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAA

>Hs.302144_mRNA_1 gi\|11493400\|gb\|AF130047.1\|AF130047 Homo sapiens clone
FLB3020 polyA = 0
CTGTCAGCACGGGGCCTGGCATGTAATTGGTCTGCACCCACTGGTGCACTGAACTGCCAT

AACCTCAGGTTTTCTTTCTTGCTGATACCCCTGGGTCATGTTCTTTGGCAAATAACATGA

TTCATTATGAAGTAGAGTTCAGCAAAGGACAAGGATGAAAGTTGTCATTTAGAGAACTGC

CATTCAGACTTTCTTGTCTAGGTAAAGAGCAAGGTCTTCTCTCTTTTCAACTCATTTTCT

AAATTTAAACTGACGATGAGAATATGGATGATGTGTAGCTTCCTTCTCCCCCACTGATTT

TTGGTTCAGGCTCTGGGTTTTTGGCAAGAACTTACAGATCTCACTTATTATTGGCCACCC

TTCTGCTTTAAGACCTGTCAGGGCTTGTCTGAAATAAAACTGGAAGCACTTCTGATTCCA

TCCTCACTGCTTTCCTCCTTCACCGTCAGACAGCATTACTGTATAGCACTGAGTGAGGGG

CCCTGACACTGGAAGGTGGCAGGTGGGGCCTGGCCGCCAGTGAGGTATCATCATTTGTGT

GTGCTCATGTGTGCGTTGGGCTTGTTGTATCTGAGGCATGAACATTCCATATACACGGCT

TAAAGAGTTTTCTTCCCATACCGAAAGCATATATTCGGAGAGGACCCAACTTATTCAGCA

TAGCCTTGTTCCCATAGTAGCCATCCTATTCCCCCACAGCCTCTACTTTAGGAAAGCTCC

CCGTCCCCATATGAAATCCAAACCAAAAAAGATATATCACTTTCAGCTCAATTATTCCAT

AATTACAAGATATTAGGCTAGTGGGCTCTTTATTGGTTGGGTCTTATATTAATGTTATAT

GCTAGCCTTGTAATTTTGAGCTCCTCTATGGATGTTAATTTTAGTGAAACTCTATATTGA

AGAAAAGATGGGACTAAGGGGGAGACAGGAGGAGGAAAGAAAGCAGAGACAGGCAAAGAA

TCATAGCCTGAAATTCAACAGCAAGCATGGCTTATGAAGATCAAGTTATATTTTTGCTTC

ATGAATCATTGTCAGACAAATTAAGAACATATTGTTTCTTATTTATCTATTGTCAAGGAT

TCACTATCAGACACTAAGAATGAATCTTGATTTTCATAAGCTCTGTTGACACCATGGAGC

CACAGAGCATAAAACTTGCATCTAATAAAGAAAGTGCAACATGGAACAGCAGGGAGTGGA

ATACCAGCACAACTCACAGCTGCTTCCTGTTCCTCGTCCCTGTTTTCAGGAATGTTTCTT

AGCAGGAAGTTTTTTAATAGACCGAGAATTTGTTATATGTATTCTAAGAAAAGTTGTAGT

TGTAGATGCATTACTCTCCCAAATCTTAGAGATCAGGGATGATTATGTTCCATTTTTGTT

TGGTGAGTTCCCATCTTTGTATGTACCTCCTTGCTCCCGGCTGTCCTCCTCTCCTCTTCC

CTAGTGAGTGGTTAATGAGTGTTAATGCCTAAACCATACTTGTTTTATGGACACTTCTAT

AATGGATTCGTTGCATAATTTTCATGCAGTGTATAGTGTTACTAGTTGGAAATTCTTGGA

GGACTCTTAGCTGTCTGATGAAATTCCTAGTAGAAATTTTTGTTTTGAATTCCTAAAGTT

GAAATATGAAAATTATATTTTAATTTGATTC

>Hs.26510_mRNA_2 gi\|11345385\|gb\|AF308803.1\|AF308803 Homo sapiens chromosome
15 map 15q26 polyA = 3
AGTTTTTCTGGTAGAAGGCGGGGTTCTCCTCGTACGCTGCGGAGTCTCTGCGGGGTGTAG

ACCGGAATCCTGCTGACGGGCAGAGTGGATCAGGGAGGGAGGGTCGAGACACGGTGGCTG

CAGGTCTGAGACAAGGCTGCTCCGAGGTAGTAGCTCTCTTGCCTGGAGGTGGCCATTCAT

TCCTGGAGTGCTGCTGAGGAGCGAGGGCCCATCTGGGGTCTCTGGAAGTCGGTGCCCAGG

CCTGAAGGATAGCCCCCCTTGCGCTTCCCTGGGCTGCGGCCGGCCTTCTCAGAACGAAGG

GCGTCCTTCCACCCCGCGGCGCAGGTGACCGCTGCCATGGCTTTTCCCCATCGGCCGGAC

GCCCCTGAGCTGCCTGACTTCTCCATGCTGAAGAGGCTGGCTCGAGACCAGCTCATCTAT

CTGCTGGAGCAGCTTCCTGGAAAAAAGGATTTATTCATTGAGGCAGATCTCATGAGCCCT

TTGGATCGAATTGCCAATGTCTCCATCCTGAAGCAACACGAAGTAGACAAGCTATACAAG

GTGGAGAACAAGCCAGCCCTCAGCTCCAATGAACAATTGTGCTTCTTGGTCAGACCCCGC

ATCAAGAATATGCGATACATTGCCAGTCTTGTCAATGCTGACAAATTGGCTGGCCGAACT

CGCAAATACAAAGTGATCTTCAGCCCTCAAAAGTTCTATGCGTGTGAGATGGTGCTTGAG

GAAGAGGGAATCTATGGAGATGTGAGCTGTGATGAATGGGCCTTCTCTTTGCTGCCTCTT

GATGTGGATCTGCTGAGCATGGAACTACCAGAATTTTTCAGGGATTACTTTCTGGAAGGA

GATCAGCGTTGGATCAACACTGTAGCTCAGGCCTTACACCTTCTCAGCACTCTCTATGGA

CCCTTTCCAAACTGCTATGGAATTGGCAGGTGCGCCAAGATGGCATATGAATTGTGGAGG

AACCTGGAGGAGGAGGAGGATGGCGAAACCAAGGGCCGAAGGCCAGAGATTGGACATATC

TTTCTCTTGGACAGAGATGTGGACTTTGTGACAGCACTTTGCTCCCAAGTGGTTTATGAG

GGCCTAGTAGATGACACCTTCCGCATCAAGTGTGGGAGTGTCGACTTTGGCCCAGAAGTC

ACATCCTCTGACAAGAGCCTGAAGGTGCTACTCAATGCCGAGGACAAGGTGTTTAATGAG

ATTCGGAACGAGCACTTCTCCAATGTCTTTGGCTTCTTGAGCCAGAAGGCCCGGAACTTG

CAGGCCCAGTATGATCGCCGGAGAGGCATGGACATTAAGCAGATGAAGAATTTCGTGTCC

CAGGAGCTCAAGGGCCTGAAACAGGAGCACCGCCTGCTGAGTCTCCATATTGGGGCCTGT

GAATCCATCATGAAGAAGAAAACCAAGCAGGATTTCCAGGAGCTAATCAAGACTGAGCAT

GCACTGCTAGAGGGGTTCAACATCCGGGAGAGCACCAGCTACATTGAGGAACACATAGAC

CGGCAGGTGTCGCCTATAGAAAGCCTGCGCCTCATGTGCCTTTTGTCCATCACTGAGAAT

GGTTTGATCCCCAAGGATTACCGATCTCTGAAAACACAGTATCTGCAGAGCTATGGCCCT

GAGCACCTGCTAACCTTCTCCAATCTGCGAAGAGCTGGGCTCCTAACGGAGCAGGCCCCC

GGGGACACCCTCACAGCCGTGGAGAGTAAAGTGAGCAAGCTGGTGACCGACAAGGCTGCA

GGAAAGATTACTGATGCCTTCAGTTCTCTGGCCAAGAGGAGCAATTTTCGTGCCATCAGC

AAAAAGCTGAATTTGATCCCACGTGTGGACGGCGAGTATGATCTGAAAGTGCCCCGAGAC

ATGGCTTACGTCTTCAGTGGTGCTTATGTGCCCCTGAGCTGCCGAATCATTGAGCAGGTG

CTAGAGCGGCGAAGCTGGCAGGGCCTTGATGAGGTGGTACGGCTGCTCAACTGCAGTGAC

TTTGCATTCACAGATATGACTAAGGAAGACAAGGCTTCCAGTGAGTCCCTGCGCCTCATC

TTGGTGGTGTTCTTGGGTGGTTGTACATTCTCTGAGATCTCAGCCCTCCGGTTCCTGGGC

AGAGAGAAAGGCTACAGGTTCATTTTCCTGACGACAGCAGTCACAAACAGCGCTCGCCTT

ATGGAGGCCATGAGTGAGGTGAAAGCCTGATGTTTTTCCCGGCCAGTGTTGACATCTTCC

CTGAACACATTCCTCAGTGAGATGCAGGCATCTGGCACCCAGCTGCTATAACCAAGTGTC

CACCAACTACCTGCTAAGAGCCGGGAGCATGGAACGTGTTGGGATTTAGAGAACATTATC

TGAGAAAAGAGTTCACTTCCTGCTCCCAGGATATTTCTCTTTTCTGTTTATGAAGTACAA

CCCATGCTGCTAAGATGCGAGCAGGAAGAGGCATCCTTTGCTAAATCCTGTTTGAATGTC

ATTGTAAATAAAGCCTCTGCTCTCAGATGTAAAAAAAAAAAAAAAAAAAAA

>Hs.324709_mRNA_2 gi\|12655026\|gb\|BC001361.1\|BC001361 Homo sapiens clone
MGC:2474 IMAGE:3050694 polyA = 2
GGCACGAGGGGTCGCGCTGCCGCCGTTTTATTTGAAGACATCGTCCAGTTCTGACCATGG

ACTCGCAGCCATCGGCCCTTAGTTTCCATCCCCTCTAGTGGGCCTTCGGGGGCTCTACTG

ACGTCCCTCCTTCCCTTGGTACCGGGCCGGGGAAGTGTTCTCGGGCGCGGGAGGTTCCGC

ATGCCCAGGCCTGGCCAGGGGAGATGACCGATCCGTCGCTGGGGCTGACAGTCCCCATGG

CGCCGCCTCTGGCCCCGCTCCCTCCCCGGGACCCAAACGGGGCGGGATCCGAGTGGAGAA

AGCCCGGGGCCGTGAGCTTCGCCGACGTGGCCGTGTACTTCTCCCGGGAGGAGTGGGGCT

GCCTGCGGCCCGCGCAGAGGGCCCTGTACCGGGACGTGATGCGGGAGACCTACGGCCACC

TGGGCGCGCTCGGTGAGAGCCCCACCTGCTTGCCTGGGCCCTGCGCCTCCACAGGCCCTG

CCGCGCCTCTGGGAGCTGCGTGTGGAGTTGGGGGCCCCGGGGCCGGGCAGGCGGCCTCCT

CGCAGCGTGGGGTTTGCGTTCTTCTCCCCCAGGAGTCGGAGGCAGCAAGCCGGCGCTCAT

CTCCTGGGTGGAGGAGAAGGCCGAACTGTGGGATCCGGCTGCCCAGGATCCGGAGGTGGC

GAAGTGTCCGACAGAAGCGGACCCAGCAGATTCCAGAAACAAGGAAGAGGAAAGACAAAG

GGAAGGGACGGGAGCCCTGGAGAAGCCCGACCCTGTGGCCGCCGGGTCTCCTGGGCTGAA

GGCTCCCCAAGCCCCCTTTGCCGGGTTGGAGCAGCTGTCCAAGGCCCGGCGCCGGAGTCG

CCCCCGCTTTTTTGCCCACCCCCCTGTCCCCCGAGCTGACCAGCGTCACGGCTGCTACGT

GTGCGGGAAGAGCTTCGCCTGGCGCTCCACACTGGTGGAGCACATTTACAGCCACAGGGG

CGAGAAGCCCTTCCACTGCGCAGACTGCGGCAAGGGCTTCGGCCACGCTTCCTCCCTGAG

CAAACACCGGGCCATCCATCGTGGGGAGCGGCCCCACCGCTGTCCCGAGTGTGGTCGGGC

CTTCATGCGCCGCACGGCGCTGACTTCTCACCTGCGCGTTCACACTGGCGAGAAGCCCTA

CCGCTGCCCGCAGTGTGGCCGCTGCTTCGGCCTGAAGACCGGCATGGCCAAGCACCAATG

GGTCCATCGGCCCGGGGGCGAGGGGCGTAGGGGCCGGCGCCCTGGGGGGCTGTCTGTGAC

CCTGACTCCTGTCCGCGGGGACCTGGACCCGCCTGTGGGCTTCCAGCTGTATCCAGAGAT

ATTCCAGGAATGTGGGTGACGGCCTAAAAAGTGACCATCTAGACATTGTGGGCGGCCCGA

GATGGGCTCAGGGGCCCGAACCTCTGCAGCGGCCTGCAGGGAGGTCCCAGAATCCACCGC

AAGAGCTGGCCTGGGGTGCGGACAGTCTGATCTTGGGCTCTCAGCAGCCTCTTCTGCCAG

CACCTTGCTCCCCGCTGCCCTGGGCTCTCCAAGGCCCCCTTTGCTGAGGCAGGGCTGAGG

TGAGAACCCCCCAGACCTCCATACAGGGAAGCAAAAGCTGTTTCTCCTCCCAGAGATGCT

AAGAGGATTGAGGTAGAGAAGAACCTTGTTTTCTCTGTTGTCTTTTTCTTTTTACTTTTT

TAATTTTTTGAGACGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGTGCGATCT

CGACTCACTGCAACTTCCACCTCCTGGAGTCAAGCGATTCTCCTGCCTCAGCCACCCAAG

TAGCTGGAATTACAGGCACCTGCCACTATGCCCGGCTAACTTTTTGTATTTTTAGTAGAG

ATGGGGTTTCACCATGTTGGCTAGGCTGGTCTCGAACTCCTGCCCTCAGGTGATCCACCC

ACCTCTGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCTCACCTGGCCTTTTCTT

TTTTATTCTTTGACCTTCCCACAAGACAATACCCATTGTCTGTTTTTTTTGTTTATTTAT

TTACTTATTAAGACAGCATCTTGCTCCTCACCCAGGCTGGAATGCAGTGGTGTGAACTGG

GCTCACTGCAGCCTAGACCTGCTGGGCTCAAGGAATCCTCCTGCCCCAGCCTCTCAGATG

GCTGTGACTACAGGTGGGCAACACTATGCCTGGTTAATTTTTAAATTTTTTTGCAGAGAT

GGGGTTCCCACTATGTTGATCAGGCTGGTCTCAAACTCCTCGGTTCAAGCAATTCGCCCA

CCTTGGCCTCCCAAAGTGCTGGGATTACAGGGGAGCCACTGCACTGGCCTTCATTGTCTT

TTTGCTGCACAACCTAAAAAACCAGTGACCCTGTATTGGAAAAAAAAAAAAAAAAAAAAA

A

>Hs.65756_mRNA_3 gi\|3641494\|gb\|AF035154.1\|AF035154 Homo sapiens chromosome
16 map 16pl3.3 polyA = 3
GCCATGGCCGCCGGCCCCGCGCCGCCCCCCGGCCGCCCCCGGGCGCAGATGCCGCATCTG

AGGAAGGTGCGAGGCGGATGGAGCGGGTGGTCGTGAGCATGCAGGACCCCGACCAGGGCG

TGAAGATGCGGAGCCAGCGCCTGCTGGTCACCGTCATTCCCCACGCGGTGACAGGCAGCG

ACGTCGTGCAGTGGTTGGCCCAGAAGTTCTGCGTCTCGGAGGAGGAGGCCCTGCACCTGG

GCGCCGTCCTGGTGCAGCATGGCTACATCTACCCGCTGCGCGACCCCCGTAGCCTCATGC

TCCGGCCAGACGAGACGCCCTACAGGTTCCAGACCCCGTACTTCTGGACAAGTACCCTGA

GGCCGGCTGCAGAGCTGGACTATGCCATCTACCTGGCCAAGAAGAACATCCGAAAACGGG

GGACCCTGGTGGATTATGAGAAGGACTGCTATGACCGGCTACACAAGAAGATCAACCACG

CATGGGACCTGGTGCTGATGCAGGCGAGGGAGCAGCTGAGGGCAGCCAAGCAGCGCAGCA

AGGGGGACAGGCTGGTCATTGCGTGCCAGGAGCAGACCTACTGGCTGGTGAACAGGCCCC

CGCCCGGGGCCCCCGATGTGCTGGAGCAGGGTCCAGGGCGGGGATCCTGCGCTGCCAGCC

GTGTGCTCATGACCAAGAGTGCAGATTTCCATAAGCGGGAGATCGAGTACTTCAGGAAAG

CGCTGGGCAGGACCCGAGTGAAGTCCTCCGTCTGCCTTGAGGCGTACCTGAGTTTCTGCG

GCCAGCGTGGACCCCACGATCCCCTCGTGTCGGGGTGCCTGCCCAGCAATCCCTGGATCT

CAGACAATGACGCCTACTGGGTCATGAATGCCCCCACGGTGGCTGCCCCCACGAAGCTCC

GTGTGGAGAGATGGGGCTTCAGCTTCCGGGAGCTCCTGGAGGACCCCGTGGGGCGGGCCC

ACTTCATGGACTTTCTGGGAAAGGAGTTCAGTGGAGAAAACCTCAGCTTCTGGGAGGCAT

GTGAGGAGCTTCGATATGGAGCGCAGGCCCAGGTCCCCACCCTGGTGGATGCCGTGTACG

AGCAGTTCCTGGCCCCCGGAGCTGCCCACTGGGTCAACATCGACAGCCGGACCATGGAGC

AGACCCTGGAGGGGCTGCGCCAGCCCCACCGCTATGTCCTGGATGACGCCCAGCTGCACA

TATACATGCTCATGAAGAAGGACTCCTACCCAAGGTTCCTGAAGTCTGACATGTACAAGG

CCCTCCTGGCAGAGGCTGGGATCCCGCTGGAGATGAAGAGACGCGTGTTCCCGTTTACGT

GGAGGCCACGGCACTCGAGCCCCAGCCCTGCACTCCTTCCCACCCCTGTGGAGCCCACAG

CGGCTTGTGGCCCTGGGGGTGGAGATGGGGTGGCCTAGTGGACCTGGCCCATCTGCCACT

CTAGTCCCTGCAGCTCAACGTCCTGCGTGAATGCAGCAGCCACCCCCGTCTTGGCCCAGG

TCCTGGGGGCTGCTGAACCCAGCACCAGTGTCCCCTTGTGCCCAGGGGGCCCAGTCTTCT

GTGGGGTGCACAGCCTCCCTCCCTCCAGCAAGCCCTCCCTGCCCAGAAGGAATGGGTCCA

GGTGTGGATTCCCAGGGAGGGGGTTCATTGGCTCAGCTTGGGTCAGGGCAGAGCCTGTTA

CCTGAAGAGAGGTGAGACCAAGGCCACAGGGAGCTCCACCTTCTCTGGTCTTCAGTCCAG

CACTGGGTGCCCATCCCCATCTCTAAAACCAGTAAATCAGCCAGCGAATACCCGGAAGCA

AGATGCACAGGCGGGCGGCTTCCCACACACCCGTCACAAGACGCGGACATGCAGGTCTCG

GCGCGAGCTCTGCCCCGTCCAAGAGCCTCTCCGCTGTCGCCCAGTGTGAGCCTGGAAGAG

GACCCAAGAGAGTGCCGTGCTGAGGCTGCCTCGAGGTCACTGCCTTCCGGAGCTGCGCCT

ATTCCTCCCTCGCCAAACGCGTTCCAGAATTTGTCCACAGGTGCGCCGGCACCTGCTTTC

CCACCTCGAGGCCGCGGCCTCCCCCCCGATTTATAGACAACTCTGACATTGTCACCCCAC

TGACGAGGCCCGATTCCATAGGGTGGATCCTTGCCAGGCGTCCCTGATCCTCCCTGCCCA

AGTCTTCCTTCGTGAGCTGGCCTTGCTCCCCATCCCCCAAGTGCCTCACCAGTCCCCCAG

ACTGGGTGAAGGTACAGCTGGCTCCTTTCGGGGGTGCAGCTTCAACTCTCTCGGCGGTAG

GGCGGTGCCATCCCCACCCATAGGGCTGGCTCACATCCAGTCACTCCCAACAGCGTCCAG

CACACAAATAAAAGACCCTTGGGCCCTGGCTCTGAGAAAAAAAA

>Hs.165743_mRNA_2 gi\|13543889\|gb\|BC006091.1\|BC006091 Homo sapiens clone
MGC:12673 IMAGE:3677524 polyA = 3
AGACTGCCGAGCAGCCTTGAGCCGTTGAGCAGCTGAACAGAGGCCATGCCGGGGCACTCC

GAGGCCTGAGACGACCACGCCTGTGCCGCTGAGGACCTTCATCAGGGCTCCGTCCACTTG

GCCCGCTTGGCTGTCCAATCACACTCCAGTGTCAACCACTGGCACCCAGCAGCCAAGAGA

GGTGTGGCGTGGCCCTGGGGACGCATGGCTGAGGCAGGAACAGGTGAGCCGTCCCCCAGC

GTGGAGGGCGAACACGGGACGGAGTATGACACGCTGCCTTCCGACACAGTCTCCCTCAGT

GACTCGGACTCTGACCTCAGCTTGCCCGGTGGTGCTGAAGTGGAAGCACTGTCCCCGATG

GGGCTGCCTGGGGAGGAGGATTCAGGTCCTGATGAGCCGCCCTCACCCCCGTCAGGCCTC

CTCCCAGCCACGGTGCAGCCATTCCATCTGAGAGGCATGAGCTCCACCTTCTCCCAGCGC

AGCCGTGACATCTTTGACTGCCTGGAGGGGGCGGCCAGACGGGCTCCATCCTCTGTGGCC

CACACCAGCATGAGTGACAACGGAGGCTTCAAGCGGCCCCTAGCGCCCTCAGGCCGGTCT

CCAGTGGAAGGCCTGGGCAGGGCCCATCGGAGCCCTGCCTCACCAAGGGTGCCTCCGGTC

CCCGACTACGTGGCACACCCCGAGCGCTGGACCAAGTACAGCCTGGAAGATGTGACCGAG

GTCAGCGAGCAGAGCAATCAGGCCACCGCCCTGGCCTTCCTGGGCTCCCAGAGCCTGGCT

GCCCCCACTGACTGCGTGTCCTCCTTCAACCAGGATCCCTCCAGCTGTGGGGAGGGGAGG

GTCATCTTCACCAAACCAGTCCGAGGGGTCGAAGCCAGACACGAGAGGAAGAGGGTCCTG

GGGAAGGTGGGAGAGCCAGGCAGGGGCGGCCTTGGGAATCCTGCCACAGACAGGGGCGAG

GGCCCTGTGGAGCTGGCCCATCTGGCCGGGCCCGGGAGCCCAGAGGCTGAGGAGTGGGGC

AGCCCCCATGGAGGCCTGCAGGAGGTGGAGGCACTGTCAGGGTCTGTCCACAGTGGGTCT

GTGCCAGGTCTCCCGCCGGTGGAAACTGTTGGCTTCCATGGCAGCAGGAAGCGGAGTCGA

GACCACTTCCGGAACAAGAGCAGCAGCCCCGAGGACCCAGGTGCTGAGGTCTGAGAGGGA

GATGGCCCAGCCTGACCCCACTGGCCACTGCCATCCTGCTGCCTTCCCAGTGGGGCTGGT

CAGGGGGCAGCCTGGCCACTGCCTAGCTGGAATGGGAGGAAGCCTGCAGGTGGCACCGGT

GGCCCTGGCTGCAGTTCTGGGCAGCATCCTCCCAAGCAGAGACCTTGCTGAAGCTCCTGG

GGTGTGGGGTGTGGGCTGGAAGCACTGGCTCCCTGGTAGGGACAATAAAGGTTTTGGGTC

TTTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAC

All references cited herein, including patents, patent applications, and publications, are hereby incorporated by reference in their entireties, whether previously specifically incorporated or not.
Having now fully described this invention, it will be appreciated by those skilled in the art that the same can be performed within a wide range of equivalent parameters, concentrations, and conditions without departing from the spirit and scope of the invention and without undue experimentation.
While this invention has been described in connection with specific embodiments thereof, it will be understood that it is capable of further modifications. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains and as may be applied to the essential features hereinbefore set forth.

Claims

1-20. (canceled)

21. A method of classifying a tumor cell-containing sample obtained from a human subject based on a tumor type or origin, wherein the tumor type or origin is selected from a plurality of known tumor types or origins, the method comprising:

amplifying five to 49 transcribed sequences,

wherein each transcribed sequence is a unique portion of one of SEQ ID NOS: 1-74 or a complement thereof,

wherein the unique portion is unique relative to other sequences expressed in the tumor cell-containing sample, and

wherein the amplification is of at least 50 nucleotides of the transcribed sequences;

determining the expression levels of the transcribed sequences and normalizing the expression levels to one or more reference genes;

comparing the normalized expression levels of the transcribed sequences from the tumor cell-containing sample to normalized expression levels of the same transcribed sequences from at least ten known tumor types or origins of a plurality of known tumor types or origins,

wherein the plurality of known tumor types or origins comprises adrenal gland, brain, breast, carcinoid-intestine, cervix-adenocarcinoma, cervix-squamous, endometrium, gall bladder, germ cell-ovary, GIST, kidney, leiomyosarcoma, liver, lung-adenocarcinoma-large cell, lung-small cell, lung-squamous, lymphoma-B cell, lymphoma-Hodgkin's, lymphoma-T cell, meningioma, mesothelioma, osteosarcoma, ovary-clear cell, ovary-serous, pancreas, prostate, skin-basal cell, skin-melanoma, skin-squamous, small and large bowel, soft tissue-liposarcoma, soft tissue-MFH, soft tissue-sarcoma-synovial, stomach-adenocarcinoma, testis-non-seminoma, testis-seminoma, thyroid-follicular-papillary, thyroid-medullary, and urinary bladder,

determining five nearest neighbors by determining five of the at least ten known tumor types or origins that have the most similar expression levels compared to the expression levels of the tumor cell-containing sample; and

a) if at least four of the five nearest neighbors share a tumor type or origin, classifying the tumor cell-containing sample as containing tumor cells of the tumor type or origin shared by at the least four of the five nearest neighbors; and

b) if fewer than four of the five nearest neighbors share a tumor type or origin, classifying the tumor cell-containing sample as containing a non-squamous cell tumor.

22. The method of claim 21, wherein the expression levels are determined by use of a microarray and the method further comprises hybridizing the amplified transcribed sequences to the microarray.

23. The method of claim 21, wherein the amplification comprises reverse transcription PCR, quantitative PCR, or real time PCR.

24. The method of claim 21, wherein the amplification comprises linear RNA amplification or quantitative PCR.

25. The method of claim 23, wherein the amplification is of sequences present within 750 nucleotides of the polyadenylation sites of the transcribed sequences.

26. The method of claim 21, wherein the tumor cell-containing sample is a formalin fixed, paraffin embedded sample.

27. The method of claim 21, further comprising, before the determining of the expression levels of the transcribed sequences,

diagnosing the human subject as in need of the determining; or

obtaining the tumor cell-containing sample from the human subject; or

receiving the tumor cell-containing sample; or

sectioning the tumor cell-containing sample; or

isolating cells from the tumor cell-containing sample; or

obtaining RNA from cells of the tumor cell-containing sample.