US20220387213A1 - Intravitreal injector - Google Patents
Intravitreal injector Download PDFInfo
- Publication number
- US20220387213A1 US20220387213A1 US17/770,184 US202017770184A US2022387213A1 US 20220387213 A1 US20220387213 A1 US 20220387213A1 US 202017770184 A US202017770184 A US 202017770184A US 2022387213 A1 US2022387213 A1 US 2022387213A1
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- US
- United States
- Prior art keywords
- needle
- plunger
- housing
- distal
- seal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000007943 implant Substances 0.000 claims abstract description 143
- 230000006835 compression Effects 0.000 claims description 20
- 238000007906 compression Methods 0.000 claims description 20
- 230000000712 assembly Effects 0.000 abstract description 4
- 238000000429 assembly Methods 0.000 abstract description 4
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000001574 biopsy Methods 0.000 description 18
- 229920000642 polymer Polymers 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 238000002513 implantation Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000012466 permeate Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000005452 bending Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 201000005111 ocular hyperemia Diseases 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004381 surface treatment Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3148—Means for causing or aiding aspiration or plunger retraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2006—Having specific accessories
- A61M2005/202—Having specific accessories cocking means, e.g. to bias the main drive spring of an injector
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/04—General characteristics of the apparatus implanted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
Definitions
- Ocular injection of solid or particulate medicament must be precise and accurate for proper treatment and prevention of further damage to the eye.
- an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a plunger assembly comprising: a plunger housing; and a plunger slidably disposed within the plunger housing, wherein a distal end of the plunger being engaged with a push pin of the needle assembly when in a distal position within the plunger housing; and a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the needle lumen being configured to receive an (e.g., one or more) implant(s) positioned therewithin; and the push pin having a head and a push rod, wherein
- the needle assembly further comprises a needle sheath and a needle seal secured by the needle sheath, wherein the distal end of the needle lumen is within and sealed by the needle seal when the system is in the sheathed state, and wherein the distal end of the needle extends beyond the needle seal when the system is in the unsheathed state.
- a distal surface of the needle seal is pierced by translating the needle sheath in a proximal direction.
- the needle has a length such that the distal end of the needle is within the needle seal when the system is in a sheathed state.
- at least a portion of the needle seal and the needle sheath are separated by a gap.
- the portion of the needle seal is a mesial portion of the needle seal. In some embodiments, at least a distal portion of the needle seal extends beyond at least a distal portion of the needle sheath.
- the injector system further comprises the implant in the needle lumen between the push pin and the seal. In some embodiments, the distal end of the plunger engages the head of the push pin. In some embodiments, the plunger is manually actuated to translate distally within the plunger housing. In some embodiments, a proximal end of the plunger assembly protrudes beyond the plunger housing. In some embodiments, the plunger is mechanically actuated to translate distally within the plunger housing.
- the plunger assembly further comprises a compression spring biasing the plunger towards a proximal end of the plunger housing.
- the compression spring has a distal end connected to the plunger housing and a proximal end connected to the plunger.
- the plunger comprises a first stop feature, wherein the plunger housing comprises a second stop feature engageable with the first stop feature.
- the second stop feature comprises a primary second stop and a secondary second stop.
- the needle assembly further comprises a resilient member disposed within the needle housing. In some embodiments, the resilient member proximally biases the push pin.
- the needle assembly further comprises a needle sheath having a proximal portion surrounding the distal end of the needle housing, and a distal portion surrounding the distal end of the needle.
- the needle sheath is removable from the needle housing by translating in a distal direction away from the needle housing to expose the needle.
- the needle sheath translates proximally to the unsheathed state where the distal end of the needle extends beyond the distal portion of the needle sheath.
- a needle assembly for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the (e.g., one or more) implant(s) from the needle lumen and into the eye of the patient.
- the needle assembly further comprises a needle sheath having a seal, wherein the distal end of the needle lumen is within and sealed by the needle seal when the system is in the sheathed state, and wherein the distal end of the needle extends beyond the needle seal when the system is in the unsheathed state.
- the needle assembly further comprises a resilient member disposed within the needle housing.
- the resilient member proximally biases the push pin.
- the resilient member is a spring, a flexure, a piston, a motor, a band, or any combination thereof.
- the needle assembly further comprises a needle sheath having a proximal portion surrounding the distal end of the needle housing, and a distal portion surrounding the distal end of the needle.
- the needle sheath is pierced by the needle by translating in a distal direction away from the needle housing to expose the needle.
- the needle sheath translates proximally to the unsheathed state where the distal end of the needle extends beyond the distal portion of the needle sheath.
- the distal portion of the needle sheath abuts the eye of the patient when the (e.g., one or more) implant(s) is ejected from the needle lumen.
- the needle assembly further comprises a needle seal at the distal end of the needle that seals the distal end of the needle lumen.
- needle seal is within a distal portion of the needle sheath.
- the needle seal is formed of a polymer.
- the needle seal is pierced by translating the needle sheath in a proximal direction.
- the needle has a length such that the distal end of the needle is within the needle seal when the system is in a sheathed state.
- the needle assembly further comprises a removable push pin retainer that prevents movement of the needle housing relative to the needle sheath when engaged.
- the removable push pin retainer removably couples the push pin to the needle housing. In some embodiments, the removable push pin retainer removably couples the needle housing to a side wall of the needle sheath. In some embodiments, the (e.g., one or more) implant(s) are loaded in the needle lumen between the distal end of the push pin and the distal end of the needle. In some embodiments, the (e.g., one or more) implant(s) have a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) comprise a plurality of particles.
- the (e.g., one or more) implant(s) have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon.
- the needle has a gauge of 20 to 40.
- the needle has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40.
- the needle has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, the needle has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of 23 to 30. In some embodiments, the needle has a gauge of 23. In some embodiments, the needle has a gauge of 30. In some embodiments, the needle is straight. In some embodiments, the needle is curved.
- an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a plunger assembly comprising: a plunger housing; and a plunger slidably disposed within the plunger housing, wherein a distal end of the plunger engages the push pin of the needle assembly when in a distal position within the plunger housing; and the needle assembly
- the distal end of the plunger engages the head of the push pin.
- the plunger is manually actuated to translate distally within the plunger housing.
- the plunger housing is a syringe barrel.
- the syringe barrel is a 1 mL syringe barrel.
- the plunger housing is a biopsy punch.
- a proximal end of the syringe plunger protrudes beyond the plunger housing.
- the plunger is mechanically actuated to translate distally within the plunger housing.
- the plunger assembly further comprises a compression spring biasing the plunger towards a proximal end of the plunger housing.
- the compression spring has a distal end connected to the plunger housing and a proximal end connected to the plunger.
- the plunger comprises a first stop feature, wherein the plunger housing comprises a second stop feature engageable with the first stop feature.
- the second stop feature comprises a primary second stop and a retracted second stop.
- an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state
- the system comprising: a plunger assembly comprising: a plunger housing; and a plunger slidably disposed within the plunger housing, wherein a distal end of the plunger engages the push pin of the needle assembly when in a distal position within the plunger housing; and a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push
- the distal end of the plunger engages the head of the push pin.
- the plunger is manually actuated to translate distally within the plunger housing.
- the plunger housing is a syringe barrel.
- the syringe barrel is a 1 mL syringe barrel.
- the plunger housing is a biopsy punch.
- a proximal end of the syringe plunger protrudes beyond the plunger housing.
- the plunger is mechanically actuated to translate distally within the plunger housing.
- the plunger assembly further comprises a compression spring biasing the plunger towards a proximal end of the plunger housing.
- the compression spring has a distal end connected to the plunger housing and a proximal end connected to the plunger.
- the plunger comprises a first stop feature, wherein the plunger housing comprises a second stop feature engageable with the first stop feature.
- the second stop feature comprises a primary second stop and a secondary second stop.
- the needle assembly further comprises a resilient member disposed within the needle housing. In some embodiments, the resilient member proximally biases the push pin.
- the resilient member is a spring, a flexure, a piston, a motor, a band, or any combination thereof.
- the needle assembly further comprises a needle sheath having a proximal portion surrounding the distal end of the needle housing, and a distal portion surrounding the distal end of the needle.
- the needle sheath is removable from the needle housing by translating in a distal direction away from the needle housing to expose the needle.
- the needle sheath translates proximally to the unsheathed state where the distal end of the needle extends beyond the distal portion of the needle sheath.
- the distal portion of the needle sheath abuts the eye of the patient when the (e.g., one or more) implant(s) are ejected from the needle lumen.
- the injector system further comprises a needle seal at the distal end of the needle that seals the distal end of the needle lumen.
- the needle seal is within a distal portion of the needle sheath.
- the needle seal is formed of a polymer.
- the needle seal is pierced by the needle by translating the needle sheath in a proximal direction.
- the needle has a length such that the distal end of the needle is within the needle seal when the system is in a sheathed state.
- the needle assembly further comprises a removable push pin retainer that prevents movement of the needle housing relative to the needle sheath when engaged.
- the removable push pin retainer removably couples the push pin to the needle housing.
- the removable push pin retainer removably couples the needle housing to a side wall of the needle sheath.
- the (e.g., one or more) implant(s) are loaded in the needle lumen between the distal end of the push pin and the distal end of the needle.
- the (e.g., one or more) implant(s) have a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) comprise a plurality of particles. In some embodiments, the (e.g., one or more) implant(s) have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon. In some embodiments, the needle has a gauge of 20 to 40. In some embodiments, the needle has a gauge of 20 to 40.
- the needle has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40.
- the needle has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, the needle has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of 23 to 30. In some embodiments, the needle has a gauge of 23. In some embodiments, the needle has a gauge of 30. In some embodiments, the needle is straight. In some embodiments, the needle is curved.
- an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state
- the system comprising: a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) are positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the (e.g., one or more) implant(s) from the needle lumen and into the eye of the patient; and a plunger assembly remov
- Another aspect provided herein is a method for injecting an (e.g., one or more) implant(s) into an eye of a patient, wherein the method comprises: providing an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the
- an injector system comprising: a needle sheath; and a needle seal secured within at least a portion of the needle sheath.
- at least a portion of the needle seal and the needle sheath are separated by a gap.
- the portion of the needle seal is a mesial portion of the needle seal.
- the portion of the needle seal is the portion secured within the needle sheath.
- at least a distal portion of the needle seal extends beyond at least a distal portion of the needle sheath.
- FIG. 1 shows a perspective illustration of an exemplary first injector system in a sheathed state, per some embodiments herein;
- FIG. 2 shows a perspective illustration of an exemplary first injector system in an unsheathed state, per some embodiments herein;
- FIG. 3 shows an exploded perspective illustration of an exemplary first injector system, per some embodiments herein;
- FIG. 4 shows a cross-sectional illustration of an exemplary first injector system in a sheathed state, per some embodiments herein;
- FIG. 5 shows a cross-sectional illustration of an exemplary first injector system in an unsheathed state, per some embodiments herein;
- FIG. 6 shows a detailed cross-sectional illustration of a needle assembly of the exemplary first injector system, per some embodiments herein;
- FIG. 7 shows a detailed cross-sectional illustration of a plunger assembly of the exemplary first injector system, per some embodiments herein;
- FIG. 8 shows a perspective illustration of an exemplary second injector system in a sheathed state, per some embodiments herein;
- FIG. 9 shows a perspective illustration of an exemplary second injector system in an unsheathed state, per some embodiments herein;
- FIG. 10 shows a cross-sectional illustration of an exemplary second injector system in a sheathed state, per some embodiments herein;
- FIG. 11 shows a cross-sectional illustration of an exemplary second injector system in an unsheathed state, per some embodiments herein;
- FIG. 12 shows a perspective illustration of a plunger assembly of an exemplary second injector system, per some embodiments herein;
- FIG. 13 shows a cross-sectioned perspective illustration of a plunger assembly of an exemplary second injector system, per some embodiments herein;
- FIG. 14 shows a perspective illustration of a needle assembly of an exemplary second injector system, per some embodiments herein;
- FIG. 15 shows a cross-sectioned perspective illustration of a needle assembly of an exemplary second injector system, per some embodiments herein;
- FIG. 16 shows a front view illustration of an exemplary injector system comprising a biopsy punch, per some embodiments herein;
- FIGS. 17 A-B show a front cross-sectioned view illustration of the exemplary injector system comprising a biopsy punch, per some embodiments herein;
- FIG. 18 shows an exploded illustration of the exemplary injector system comprising a biopsy punch, per some embodiments herein;
- FIG. 19 shows an exploded illustration of an exemplary injector system comprising a biopsy punch and a retractable needle seal, per some embodiments herein;
- FIG. 20 shows exploded and cross-sectioned illustrations of an exemplary injector system comprising a syringe and a retractable needle seal, per some embodiments herein;
- FIG. 21 shows an illustration of an exemplary injector system comprising a biopsy punch within a syringe or other full-length tube, per some embodiments herein;
- FIG. 22 shows illustrations of an exemplary injector system comprising a syringe and a primary needle and removable needle seal assembly in an unsheathed and a sheathed state, per some embodiments herein;
- FIG. 23 shows illustrations of an exemplary injector system comprising a syringe and a secondary needle and removable needle seal assemblies, per some embodiments herein;
- FIG. 24 shows an illustration of an exemplary injector system comprising a syringe and a removable push pin retainer, per some embodiments herein;
- FIG. 25 shows a perspective cross-sectioned illustration of an exemplary third injector system, per some embodiments herein;
- FIG. 26 shows front view illustrations of exemplary plungers of the third injector system, per some embodiments herein;
- FIG. 27 shows a first set detailed front view illustrations of exemplary plungers of the third injector system, per some embodiments herein;
- FIG. 28 shows a second set detailed front view illustrations of exemplary plungers of the third injector system, per some embodiments herein;
- FIG. 29 shows a third set detailed front view illustrations of exemplary plungers of the third injector system, per some embodiments herein;
- FIG. 30 shows front cross-sectioned view illustrations of an exemplary plunger housing of the third injector system, per some embodiments herein;
- FIG. 31 shows a fourth detailed front view illustration of an exemplary plunger of the third injector system, per some embodiments herein;
- FIG. 32 A shows a front cross-sectioned view illustration of an exemplary secondary needle seal, per some embodiments herein;
- FIG. 32 B shows a front-top perspective view illustration of an exemplary secondary needle seal, per some embodiments herein;
- FIG. 32 C shows a front plan view illustration of an exemplary secondary needle seal, per some embodiments herein;
- FIG. 33 A shows a front cross-sectioned view illustration of an exemplary secondary needle sheath and an exemplary secondary needle seal, per some embodiments herein;
- FIG. 33 B shows a front cross-sectioned view illustration of an exemplary secondary needle sheath and an exemplary secondary needle seal being pierced by a needle, per some embodiments herein;
- FIG. 34 A shows illustrations of two exemplary implants loaded in parallel into an exemplary needle, per some embodiments herein;
- FIG. 34 B shows illustrations of two exemplary implants loaded in series into an exemplary needle, per some embodiments herein.
- a first injector system 100 for injecting an (e.g., one or more) implant(s) 300 into an eye of a patient, the system 100 comprising a needle assembly 210 and a plunger assembly 110 .
- the needle assembly 210 removably couples to a distal end of the plunger assembly 110 .
- the needle assembly 210 removably couples to a distal end of the plunger assembly 110 by a snap, a screw, a pin, a band, a clamp, or any combination thereof.
- the needle assembly 210 permanently couples to the plunger assembly 110 .
- the needle assembly 210 is maneuverable between a sheathed state and an unsheathed state.
- FIG. 1 shows a sheathed state of the needle assembly 210
- FIG. 2 shows an unsheathed state of the needle assembly 210 .
- the plunger assembly 110 is maneuverable between an extended position and a retracted position.
- the exemplary needle assembly 210 comprises a needle housing 250 , a needle 260 , and a push pin 290 .
- the needle assembly 210 further comprises the (e.g., one or more) implant(s) 300 loaded in the needle 260 .
- the needle assembly 210 further comprises the (e.g., one or more) implant(s) 300 loaded in a lumen of the needle 260 .
- the (e.g., one or more) implant(s) 300 comprise a first implant 300 A and a second implant 300 B, wherein the first implant 300 A and the second implant 300 B are loaded in parallel into the needle 260 .
- the first implant 300 A and the second implant 300 B are held within the needle 260 such that their longitudinal axes of symmetry are within about 10 degrees of parallel. In some embodiments, the first implant 300 A and the second implant 300 B are held within the needle 260 such that their longitudinal axes of symmetry at least partially overlap. In some embodiments, per FIG. 34 B , the first implant 300 A and the second implant 300 B are sequentially loaded in series into the needle 260 . In some embodiments, the first implant 300 A and the second implant 300 B are held within the needle 260 such that their longitudinal axes of symmetry are within about 10 degrees of being coaxial.
- the first implant 300 A and the second implant 300 B are held within the needle 260 such a proximal point of the first implant 300 A contacts a distal point of the second implant 300 B.
- the first implant 300 A and the second implant 300 B are ejected from the needle 260 simultaneously.
- the first implant 300 A and the second implant 300 B are ejected from the needle 260 in series.
- the first implant 300 A and the second implant 300 B are embedded in a solid or liquid media that maintains a set distance between one or more of their surfaces.
- the needle housing 250 has a proximal end and a distal end. Further, as shown, the needle housing 250 comprises a male luer taper, a thru-hole, a first cavity, and a second cavity. Alternatively, in some embodiments, the needle housing 250 does not comprise one or more of the male luer taper, the thru-hole, the first cavity, and the second cavity. In some embodiments, two or more of the male luer taper, the thru-hole, the first cavity, and the second cavity are concentric. As shown, a distal termination of the first cavity is distal to the distal termination of the male luer taper. As shown, a proximal termination of the first cavity is distal to the distal termination of the male luer taper.
- the needle 260 comprises a needle lumen at the distal end of the needle 260 and a female luer taper at the proximal end of the needle 260 .
- the needle 260 does not comprise a female luer taper.
- the needle 260 has a gauge of 20 to 40.
- the needle 260 has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40.
- the needle 260 has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle 260 has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, the needle 260 has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle 260 has a gauge of 23 to 30. In some embodiments, the needle 260 has a gauge of 23. In some embodiments, the needle 260 has a gauge of 30. In some embodiments, the needle 260 is straight. In some embodiments, the needle 260 is curved.
- the curved needle 260 has a curvature radius of about 10, 20, 30, 40, 50, 60, 70, 80, 90 mm or more.
- the needle 260 is twisted.
- the twisted needle 260 has a pitch of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more.
- the twisted needle 260 has a maximum outer diameter of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more.
- the needle 260 is a commercially available needle 260 .
- the exemplary push pin 290 has a head and a push rod. Further, as shown, the head is positioned proximally to the push rod. As shown a proximal end of the needle 260 is coupled to the distal end of the needle housing 250 and the push pin 290 is disposed within the needle housing 250 . Alternatively, in some embodiments, a proximal end of the needle 260 is within the needle housing 250 . As shown, the push rod of the push pin 290 has an outer diameter of less than the inner diameter of the thru-hole of the needle housing 250 .
- the needle assembly 210 further comprises a resilient member 280 disposed within the needle housing 250 .
- the resilient member 280 proximally biases the push pin 290 .
- the resilient member 280 proximally biases the push pin 290 when the needle assembly 210 is in a sheathed state.
- the resilient member 280 proximally biases the push pin 290 when the needle assembly 210 is in an unsheathed state.
- the resilient member 280 is a spring.
- the resilient member 280 is a flexure, a piston, a motor, a band, or any combination thereof.
- the resilient member 280 is disposed within and constrained by the first cavity of the needle housing 250 . In some embodiments, the resilient member 280 has an outer diameter of less than an inner diameter of the first cavity of the needle housing 250 . As shown, the push rod of the push pin 290 has an outer diameter of less than an inner diameter of the resilient member 280 .
- the needle assembly 210 further comprises a needle sheath 270 surrounding at least a portion of the needle housing 250 , and having a distal portion surrounding the distal end of the needle 260 .
- a proximal portion of the needle sheath 270 surrounds the distal end of the needle housing 250 .
- a distal face of the needle sheath 270 is more distal to the needle housing 250 in the sheathed state of the needle assembly 210 than in the unsheathed state of the needle assembly 210 .
- a distal face of the needle sheath 270 is more distal to the plunger housing 120 in the sheathed state of the needle assembly 210 than in the unsheathed state of the needle assembly 210 .
- the needle 260 when the needle assembly 210 is sheathed, the needle 260 is entirely surrounded by the needle sheath 270 . In some embodiments, when the needle assembly 210 is in the unsheathed state, at least a portion of the needle 260 extends distally beyond the needle sheath 270 . In some embodiments, the distal portion of the needle sheath 270 abuts the eye of the patient when the (e.g., one or more) implant(s) 300 are ejected from the needle lumen. In some embodiments, the distal portion of the needle sheath 270 abuts the eye of the patient when the needle assembly 210 is in its sheathed state.
- the distal portion of the needle sheath 270 abuts the eye of the patient when the needle assembly 210 is in its unsheathed state. In some embodiments, the distal portion of the needle sheath 270 abuts the eye of the patient when the needle lumen is within the eye of the patient. In some embodiments, the distal portion of the needle sheath 270 abuts the eye of the patient when the needle lumen is within the needle sheath 270 . In some embodiments, the needle sheath 270 is removable from the needle housing 250 . In some embodiments, the needle sheath 270 is removable from the needle housing 250 by translation of the needle sheath 270 in a distal direction with respect to the needle housing 250 . In some embodiments, the needle sheath 270 is removable from the needle housing 250 by translation of the needle sheath 270 in a proximal direction with respect to the needle housing 250 .
- the first injector system 100 further comprises a needle seal 271 at the distal end of the needle 260 that seals the distal end of the needle lumen.
- the needle seal 271 is within a distal portion of the needle sheath 270 .
- the needle seal 271 is molded within a distal portion of the needle sheath 270 .
- the needle seal 271 is adhered or coupled to a distal portion of the needle sheath 270 .
- the needle seal 271 is formed of a polymer. In some embodiments, the polymer is rubber, plastic, or both.
- the needle seal 271 is removable. In some embodiments, translating the needle sheath 270 in a proximal direction causes the needle 260 to pierce the needle seal 271 .
- FIGS. 32 A- 32 B show an exemplary secondary needle seal 3271 and an exemplary secondary needle sheath 3270 .
- at least a distal portion of the needle 260 is sealed within the secondary needle seal 3271 .
- at least a distal portion of the bevel of the needle 260 is sealed within the secondary needle seal 3271 .
- at least a majority of the bevel of the needle 260 is sealed within the secondary needle seal 3271 .
- at least the bevel of the needle 260 is sealed within the secondary needle seal 3271 .
- the secondary needle seal 3271 seals an (e.g., one or more) implant(s) within the lumen needle 260 .
- At least a distal portion of the needle 260 is sealed within the secondary needle seal 3271 in the sheathed state of the injector system. In some embodiments, at least a distal portion of the bevel of the needle 260 is sealed within the secondary needle seal 3271 in the sheathed state of the injector system. In some embodiments, at least a majority of the bevel of the needle 260 is sealed within the secondary needle seal 3271 in the sheathed state of the injector system. In some embodiments, at least the bevel of the needle 260 is sealed within the secondary needle seal 3271 in the sheathed state of the injector system.
- the secondary needle seal 3271 seals an (e.g., one or more) implant(s) within the lumen needle 260 in the sheathed state of the injector system. In some embodiments, at least a portion of the implants are ejected from the in the sheathed state of the injector system secondary needle seal 3271 in the unsheathed state of the injector system.
- the secondary needle seal 3271 comprises a distal portion 3271 A, a proximal portion 3271 C, and a mesial portion 3271 B between the distal portion 3271 A and the proximal portion 3271 C.
- the secondary needle seal 3271 is axisymmetric.
- an outer surface of the distal portion 3271 A is generally convex.
- an outer surface of the mesial portion 3271 B is generally in the form of a conical frustum.
- the outer surface of the proximal portion 3271 C is generally cylindrical.
- a bottom surface of the secondary needle seal 3271 on the proximal portion 3271 A comprises a divot 3271 D.
- the divot 3271 D is conical.
- the divot 3271 D is cylindrical, a conical frustum, or any other prism.
- an axis of symmetry (shown as vertical) of the divot 3271 D is generally coaxial with the axis of symmetry of the secondary needle seal 3271 .
- an axis of symmetry of the divot 3271 D is generally coaxial with the axis of symmetry of the needle 260 .
- the divot 3271 D is configured to accept and/or align the needle 260 . In some embodiments, the divot 3271 D is configured to direct the needle 260 away from compressed areas of the secondary needle seal 3271 . In some embodiments, one or more edges of the secondary needle seal 3271 are rounded.
- the boundary between the distal portion 3271 A and a first end of the mesial portion 3271 B forms a distal seal lip 3271 E that extends perpendicular to the axis of symmetry of the secondary needle seal 3271 .
- the boundary between the proximal portion 3271 A and a second end of the mesial portion 3271 B, opposite the first end forms a proximal seal lip 3271 F that extends perpendicular to the axis of symmetry of the secondary needle seal 3271 .
- the minimum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the distal portion 3271 A. In some embodiments, the maximum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the distal portion 3271 A. In some embodiments, the minimum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the proximal portion 3271 C. In some embodiments, the maximum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the proximal portion 3271 C.
- the exemplary secondary needle sheath 3270 is configured to accept the secondary needle seal 3271 .
- the exemplary secondary needle sheath 3270 is configured to accept the secondary needle seal 3271 such that a gap 3201 exists between the exemplary secondary needle sheath 3270 and the mesial portion 3721 A of the secondary needle seal 3271 .
- the gap 3201 allows the secondary needle seal 3271 to expand when the needle 260 is inserted therethrough.
- the gap 3201 enables the secondary needle sheath 3270 to securely retain the secondary needle seal 3271 with minimal radial compression.
- reduced radial compression prevents coring of the secondary needle seal 3271 .
- the gap 3201 enables air to permeate out of the secondary needle sheath 3270 and around at least a portion of the secondary needle seal 3271 .
- the gap 3201 allows the secondary needle seal 3271 to expand when the needle 260 is inserted therethrough, to prevent coring of the secondary needle seal 3271 .
- a distal surface of the secondary needle sheath 3270 is flattened to form a distal sheath seal lip 3270 F that mates with the distal seal lip 3271 E of the secondary needle seal 3271 .
- the secondary needle sheath 3270 comprises a proximal sheath seal lip 3270 F, that mates with the proximal seal lip 3271 F of the of the secondary needle seal 3271 .
- the distal sheath seal lip 3270 E and the proximal seal lip 3271 F at least partially constrain translational and/or rotational movement of the secondary needle seal 3271 with in the secondary needle sheath 3270 .
- the first injector system 100 further comprises a collar 240 , a push pin housing 230 , and a collar sleeve 220 .
- the collar sleeve 220 couples to the needle housing 250 .
- the collar sleeve 220 couples to the needle housing 250 by a snap.
- the collar sleeve 220 couples to the needle housing 250 via a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof.
- the push pin housing 230 couples to the needle housing 250 by a snap, a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof.
- a distal outer diameter of the push pin housing 230 is less than an inner diameter of the second cavity of the needle housing 250 .
- the push pin housing 230 comprises a chamfered thru-hole receiving a portion of the head of the push pin 290 to maintain alignment of the push pin 290 as it travels distally and proximally.
- the chamfered thru-hole receives a portion of the distal end of the plunger 130 , wherein the chamfer maintains alignment of the distal end of the plunger 130 against the head of the push pin 290 .
- the plunger 130 comprises a first plunger outer diameter and a second plunger outer diameter distal to the first plunger outer diameter, wherein the second plunger outer diameter is smaller than the first plunger outer diameter.
- the first plunger outer diameter is larger than the inner diameter of the chamfered thru-hole in the push pin housing 230 .
- the second plunger outer diameter is smaller than the inner diameter of the chamfered thru-hole in the push pin housing 230 .
- the collar 240 couples to the collar sleeve 220 .
- the collar 240 when coupled to the collar sleeve 220 , prevents the needle sheath 270 from translating in a distal direction, a proximal direction or both.
- the collar 240 when decoupled from the collar sleeve 220 , allows the needle sheath 270 to translate in a distal direction, a proximal direction or both.
- the needle assembly 210 is in a sheathed state, per FIG. 4 , when the collar 240 is coupled to the collar sleeve 220 .
- the needle assembly 210 is in an unsheathed state, per FIG. 5 , when the collar 240 is decoupled from the collar sleeve 220 .
- the collar 240 couples to the collar sleeve 220 by rotating the collar 240 , translating the collar 240 , or both with respect to the collar sleeve 220 .
- the collar 240 decouples from the collar sleeve 220 by rotating the collar 240 , translating the collar 240 , or both with respect to the collar sleeve 220 .
- the collar 240 comprises a tab to enable rotation of the collar 240 , translation of the collar 240 , or both with respect to the collar sleeve 220 .
- At least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction ejects the (e.g., one or more) implant(s) 300 positioned inside the needle lumen out of the needle lumen and into the eye of the patient.
- at least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction partially ejects the (e.g., one or more) implant(s) 300 out of the needle lumen.
- At least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen. In some embodiments, at least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- At least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- At least one of the push pin 290 , the needle housing 250 , and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 distal to the distal end of the needle 260 .
- at least one of the push pin 290 , the needle housing 250 , and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 distal to the distal end of the needle 260 by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- At least one of the push pin 290 , the needle housing 250 , and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 distal to the distal end of the needle 260 by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of the push pin 290 , the needle housing 250 , and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 distal to the distal end of the needle 260 by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- At least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 proximal to the distal end of the needle 260 . In some embodiments, at least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 proximal to the distal end of the needle 260 by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- At least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 proximal to the distal end of the needle 260 by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of the push pin 290 , the needle housing 250 and the needle 260 is dimensioned such that translating the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 proximal to the distal end of the needle 260 by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- At least one of the push pin 290 , the needle housing 250 , or the needle 260 is dimensioned such that applying an actuating force on the push pin 290 in a distal direction positions a distal end of the push rod of the push pin 290 distal to the distal end of the needle 260 .
- the push pin 290 retracts within the needle 260 after the actuating force is removed.
- the push pin 290 retracts within the needle 260 by a distance of at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- the push pin 290 retracts within the needle 260 by a distance of at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- the push pin 290 retracts within the needle 260 by a distance of 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm from the distal face of the needle 260 after the actuating force is removed.
- the needle 260 has a length such that the distal end of the needle 260 is within the needle seal when the needle assembly 210 is in a sheathed state. Further, as shown, at least a portion of the push rod of the push pin 290 is disposed within the needle 260 , and at least a portion of the push pin 290 is disposed within the needle housing 250 . As shown a distal portion of the push pin 290 is disposed within the needle 260 , and a proximal portion of the push pin 290 is disposed within the needle housing 250 .
- a distal end of the needle 260 extends beyond the distal end of the needle housing 250 .
- a distal end of the needle 260 extends beyond the distal end of the needle housing 250 by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm or more.
- a distal end of the needle 260 extends beyond the distal end of the needle housing 250 by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- a distal end of the needle 260 extends beyond the distal end of the needle housing 250 by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm.
- the push rod of the push pin 290 translates within the needle lumen.
- the push rod has an outer diameter of less than the inner diameter of the needle 260 .
- the head has an outer diameter greater than the inner diameter of the needle 260 .
- the head does not fit within the needle 260 .
- at least a portion of the head does not fit within the needle 260 .
- the push pin 290 is dimensioned and positioned in the needle lumen such that distal translating of the push pin 290 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen.
- the push pin 290 is dimensioned and positioned in the needle lumen such that distal translating of the push pin 290 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen. In some embodiments, the push pin 290 is dimensioned and positioned in the needle lumen such that distal translating of the push pin 290 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen into the eye of the patient. In some embodiments, a distal surface of the push rod of the push pin 290 contacts the distal portion of the (e.g., one or more) implant(s) 300 in the extended position, the retracted position, or both of the plunger assembly 200 .
- the (e.g., one or more) implant(s) 300 has a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) 300 comprise a plurality of particles. In some embodiments, the (e.g., one or more) implant(s) 300 have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon.
- the needle 260 has a length such that the distal end of the needle 260 is within the needle seal when the needle assembly 210 is in the sheathed state. In some embodiments, the needle 260 has a length of about 5 mm to about 70 mm.
- the needle 260 has a length of about 5 mm to about 10 mm, about 5 mm to about 15 mm, about 5 mm to about 20 mm, about 5 mm to about 25 mm, about 5 mm to about 30 mm, about 5 mm to about 35 mm, about 5 mm to about 40 mm, about 5 mm to about 45 mm, about 5 mm to about 50 mm, about 5 mm to about 60 mm, about 5 mm to about 70 mm, about 10 mm to about 15 mm, about 10 mm to about 20 mm, about 10 mm to about 25 mm, about 10 mm to about 30 mm, about 10 mm to about 35 mm, about 10 mm to about 40 mm, about 10 mm to about 45 mm, about 10 mm to about 50 mm, about 10 mm to about 60 mm, about 10 mm to about 70 mm, about 15 mm to about 20 mm, about 15 mm to about 25 mm, about 15 mm to about 30 mm, about
- the needle 260 has a length of about 5 mm, about 10 mm, about 15 mm, about 20 mm, about 25 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm. In some embodiments, the needle 260 has a length of at least about 5 mm, about 10 mm, about 15 mm, about 20 mm, about 25 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, or about 60 mm.
- the needle 260 has a length of at most about 10 mm, about 15 mm, about 20 mm, about 25 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm.
- the length of the needle 260 is a maximum length, a minimum length, a normal length, or an average length.
- the injector system 100 comprises a plunger housing 120 , a plunger 130 , and a compression spring 140 .
- the plunger 130 is slidably disposed within the plunger housing 120 .
- a distal end of the plunger 130 is adapted to engage and push the push pin 290 of the needle assembly 210 when in a distal position within the plunger housing 120 .
- the distal end of the plunger 130 engages the head of the push pin 290 of the needle assembly 210 .
- the plunger 130 is manually actuated to translate distally within the plunger housing 120 .
- the plunger housing 120 is a syringe barrel.
- the syringe barrel is a 1 mL syringe barrel.
- a proximal end of the syringe plunger 130 protrudes beyond the plunger housing 120 .
- the plunger 130 is mechanically actuated to translate distally within the plunger housing 120 .
- the plunger assembly 110 further comprises a compression spring 140 biasing the plunger 130 towards a proximal end of the plunger housing 120 .
- the compression spring 140 has a distal end connected to the plunger housing 120 and a proximal end connected to the plunger 130 .
- the plunger housing 120 is a biopsy punch.
- the plunger 130 comprises a first stop feature 131 , wherein the plunger housing 120 comprises a second stop 121 122 123 feature engageable with the first stop feature 131 .
- the second stop feature comprises a primary second stop 121 and a secondary second stop 122 .
- the second stop feature comprises a primary second stop 121 , a secondary second stop 122 , and a tertiary second stop 123 .
- the second stop feature does not comprise the tertiary second stop 123 .
- the first stop feature 131 engages with the primary second stop 121 in the retracted position of the plunger assembly 110 .
- the first stop feature 131 engages with the secondary second stop 122 in the extended position of the plunger assembly 110 . In some embodiments, the first stop feature 131 engages with the secondary second stop 122 in a first extended position of the plunger assembly 110 . In some embodiments, the first stop feature 131 engages with the tertiary stop 123 in a second extended position of the plunger assembly 110 . In some embodiments, per FIG. 34 B , the injector system 100 ejects a first implant 300 in the first extended position, and ejects a second implant 300 in the second extended position. In some embodiments, the first stop feature 131 engages with the secondary second stop 122 only in the unsheathed state of the needle assembly 210 .
- the first stop feature 131 engages with the secondary second stop 122 in the extended position or the first extended position of the plunger assembly 110 , wherein upon implantation, distal force on the plunger advances the first stop feature 131 past the secondary second stop 122 by a retraction distance, whereafter reduction or release of the distal force returns the first stop feature 131 proximally by the retraction distance to engage with the secondary second stop 122 .
- the first stop feature 131 engages with the tertiary second stop 123 in the second extended position of the plunger assembly 110 , wherein upon implantation, distal force on the plunger advances the first stop feature 131 past the tertiary second stop 123 by a retraction distance, whereafter reduction or release of the distal force returns the first stop feature 131 proximally by the retraction distance to engage with the tertiary second stop 123 .
- the first stop feature 131 comprises a flexure, wherein the primary second stop 121 and the secondary second stop 122 comprise a slot.
- the first stop feature 131 comprises a snap, a detent, a spring, a clip, or any combination thereof.
- the primary second stop 121 and the secondary second stop 122 comprise a snap, a detent, a spring, a clip, or any combination thereof.
- the secondary second stop 122 is distal to the primary second stop 121 .
- a distance between the primary second stop 121 and the secondary second stop 122 determines the distance that the plunger 130 translates from the extended position to the retracted position.
- a distance between the primary second stop 121 and the secondary second stop 122 determines the distance that the push pin 290 translates.
- a distance between the primary second stop 121 and the secondary second stop 122 determines the distance that the (e.g., one or more) implant(s) 300 translate.
- a distance between the primary second stop 121 and the secondary second stop 122 minus the length of the (e.g., one or more) implant(s) 300 determines the distance that the (e.g., one or more) implant(s) 300 are deposited into the eye of a subject.
- the plunger 130 comprises a first plunger outer diameter and a second plunger outer diameter distal to the first plunger outer diameter, wherein the second plunger outer diameter is smaller than the first plunger outer diameter.
- the first plunger outer diameter is larger than the inner diameter of the chamfered thru-hole in the push pin housing 230 .
- the second plunger outer diameter is smaller than the inner diameter of the chamfered thru-hole in the push pin housing 230 .
- a second injector system 800 for injecting an (e.g., one or more) implant(s) 300 into an eye of a patient, the system comprising a needle assembly 910 and a plunger assembly 810 .
- the needle assembly 910 removably couples to a distal end of the plunger assembly 810 .
- the needle assembly 910 removably couples to a distal end of the plunger assembly 810 by a snap, a screw, a pin, a band, a clamp, or any combination thereof.
- the needle assembly 910 permanently couples to the plunger assembly 810 .
- the needle assembly 910 is maneuverable between a sheathed state and an unsheathed state.
- FIG. 8 shows a sheathed state of the needle assembly 910
- FIG. 2 shows an unsheathed state of the needle assembly 910 .
- the plunger assembly 810 is maneuverable between an extended position and a retracted position.
- the exemplary needle assembly 910 comprises a needle housing 950 , a needle 260 , and a push pin 990 .
- the needle assembly 910 further comprises the (e.g., one or more) implant(s) 300 loaded in the needle 260 .
- the needle assembly 910 further comprises the (e.g., one or more) implant(s) 300 loaded in a lumen of the needle 260 .
- per FIG. 10 per FIG.
- the (e.g., one or more) implant(s) 300 comprise a first implant 300 A and a second implant 300 B, wherein the first implant 300 A and the second implant 300 B are loaded in parallel into the needle 260 .
- the first implant 300 A and the second implant 300 B are held within the needle 260 such that their longitudinal axes of symmetry are within about 10 degrees of parallel.
- the first implant 300 A and the second implant 300 B are held within the needle 260 such that their longitudinal axes of symmetry at least partially overlap.
- the first implant 300 A and the second implant 300 B are sequentially loaded in series into the needle 260 .
- the first implant 300 A and the second implant 300 B are held within the needle 260 such that their longitudinal axes of symmetry are within about 10 degrees of being coaxial. In some embodiments, the first implant 300 A and the second implant 300 B are held within the needle 260 such a proximal point of the first implant 300 A contacts a distal point of the second implant 300 B. In some embodiments, the first implant 300 A and the second implant 300 B are ejected from the needle 260 simultaneously. In some embodiments, the first implant 300 A and the second implant 300 B are ejected from the needle 260 in series. In some embodiments, the first implant 300 A and the second implant 300 B are embedded in a solid or liquid media that maintains a set distance between one or more of their surfaces.
- the needle housing 950 has a proximal end and a distal end. Further, as shown, the needle housing 950 comprises a male luer taper, a thru-hole, a first cavity, and a second cavity. Alternatively, in some embodiments, the needle housing 950 does not comprise one or more of the male luer taper, the thru-hole, the first cavity, and the second cavity. In some embodiments, two or more of the male luer taper, the thru-hole, the first cavity, and the second cavity are concentric. As shown, a distal termination of the first cavity is distal to the distal termination of the male luer taper. As shown, a proximal termination of the first cavity is distal to the distal termination of the male luer taper.
- the needle 260 comprises a needle lumen at the distal end of the needle 260 and a female luer taper at the proximal end of the needle 260 .
- the needle 260 has a gauge of 90 to 40.
- the needle 260 has a gauge of 90 to 92, 90 to 94, 90 to 96, 90 to 98, 90 to 30, 90 to 32, 90 to 34, 90 to 36, 90 to 38, 90 to 40, 92 to 94, 92 to 96, 92 to 98, 92 to 30, 92 to 32, 92 to 34, 92 to 36, 92 to 38, 92 to 40, 94 to 96, 94 to 98, 94 to 30, 94 to 32, 94 to 34, 94 to 36, 94 to 38, 94 to 40, 96 to 98, 96 to 30, 96 to 32, 96 to 34, 96 to 36, 96 to 38, 96 to 40, 98 to 30, 98 to 32, 98 to 34, 98 to 36, 98 to 38, 98 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 30 to 36, 30 to 38, 30 to
- the needle 260 has a gauge of 90, 92, 94, 96, 98, 30, 32, 34, 36, 38or 40. In some embodiments, the needle 260 has a gauge of at least 90, 92, 94, 96, 98, 30, 32, 34, 36, or 38. In some embodiments, the needle 260 has a gauge of at most 92, 94, 96, 98, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle 260 has a gauge of 93 to 30. In some embodiments, the needle 260 has a gauge of 93. In some embodiments, the needle 260 has a gauge of 30. In some embodiments, the needle 260 is straight.
- the needle 260 is curved. In some embodiments, the curved needle 260 has a curvature radius of about 80, 90, 30, 40, 50, 60, 70, 80, 90 mm or more. In some embodiments, the needle 260 is twisted. In some embodiments, the twisted needle 260 has a pitch of about 5, 80, 85, 90, 95, 30, 35, 40, 45, 50 mm or more. In some embodiments, the twisted needle 260 has a maximum outer diameter of about 5, 80, 85, 90, 95, 30, 35, 40, 45, 50 mm or more. In some embodiments, the needle 260 is a commercially available needle.
- the exemplary push pin 990 has a head and a push rod. Further, as shown, the head is positioned proximally to the push rod. As shown a proximal end of the needle 260 is coupled to the distal end of the needle housing 950 and the push pin 990 is disposed within the needle housing 950 . Alternatively, in some embodiments, a proximal end of the needle 260 is within the needle housing 950 . As shown, the push rod of the push pin 990 has an outer diameter of less than the inner diameter of the thru-hole of the needle housing 950 .
- the needle assembly 910 further comprises a resilient member 980 disposed within the needle housing 950 .
- the resilient member 980 proximally biases the push pin 990 .
- the resilient member 980 proximally biases the push pin 990 when the needle assembly 910 is in a sheathed state.
- the resilient member 980 proximally biases the push pin 990 when the needle assembly 910 is in an unsheathed state.
- the resilient member 980 is a spring.
- the resilient member 980 is a flexure, a piston, a motor, a band, or any combination thereof.
- the resilient member 980 is disposed within and constrained by the first cavity of the needle housing 950 . In some embodiments, the resilient member 980 has an outer diameter of less than an inner diameter of the first cavity of the needle housing 950 . As shown, the push rod of the push pin 990 has an outer diameter of less than an inner diameter of the resilient member 980 .
- the needle assembly 910 further comprises a needle sheath 970 surrounding at least a portion of the needle housing 950 , and having a distal portion surrounding the distal end of the needle 260 .
- a proximal portion of the needle sheath 970 surrounds the distal end of the needle housing 950 .
- a distal face of the needle sheath 970 is more distal to the needle housing 950 in the sheathed state of the needle assembly 910 than in the unsheathed state of the needle assembly 910 .
- a distal face of the needle sheath 970 is more distal to the plunger housing 120 in the sheathed state of the needle assembly 910 than in the unsheathed state of the needle assembly 910 .
- the needle 260 when the needle assembly 910 is the sheathed, the needle 260 is entirely surrounded by the needle sheath 970 . In some embodiments, when the needle assembly 910 is in the unsheathed state, at least a portion of the needle 260 extends distally beyond the needle sheath 970 . In some embodiments, the distal portion of the needle sheath 970 abuts the eye of the patient when the (e.g., one or more) implant(s) 300 are ejected from the needle lumen. In some embodiments, the distal portion of the needle sheath 970 abuts the eye of the patient when the needle assembly 910 is in its sheathed state.
- the distal portion of the needle sheath 970 abuts the eye of the patient when the needle assembly 910 is in its unsheathed state. In some embodiments, the distal portion of the needle sheath 970 abuts the eye of the patient when the needle lumen is within the eye of the patient. In some embodiments, the distal portion of the needle sheath 970 abuts the eye of the patient when the needle lumen is within the needle sheath 970 . In some embodiments, the needle sheath 970 is removable from the needle housing 950 . In some embodiments, the needle sheath 970 is removable from the needle housing 950 by translation of the needle sheath 970 in a distal direction with respect to the needle housing 950 . In some embodiments, the needle sheath 970 is removable from the needle housing 950 by translation of the needle sheath 970 in a proximal direction with respect to the needle housing 950 .
- the second injector system 800 further comprises a needle seal 971 at the distal end of the needle 260 that seals the distal end of the needle lumen.
- the needle seal 971 is within a distal portion of the needle sheath 970 .
- the needle seal 971 is molded within a distal portion of the needle sheath 970 .
- the needle seal 971 is adhered or coupled to a distal portion of the needle sheath 970 .
- the needle seal 971 is formed of a polymer. In some embodiments, the polymer is rubber, plastic, or both.
- the needle seal 971 is removable. In some embodiments, translating the needle sheath 970 in a proximal direction causes the needle 260 to pierce the needle seal 971 .
- FIGS. 32 A- 32 B show an exemplary secondary needle seal 3271 and an exemplary secondary needle sheath 3270 .
- the secondary needle seal 3271 comprises a distal portion 3271 A, a proximal portion 3271 C, and a mesial portion 3271 B between the distal portion 3271 A and the proximal portion 3271 C.
- the secondary needle seal 3271 is axisymmetric.
- an outer surface of the distal portion 3271 A is generally convex.
- an outer surface of the mesial portion 3271 B is generally in the form of a conical frustum.
- the outer surface of the proximal portion 3271 C is generally cylindrical.
- a bottom surface of the secondary needle seal 3271 on the proximal portion 3271 A comprises a divot 3271 D.
- the divot 3271 D is conical.
- the divot 3271 D is cylindrical, a conical frustum, or any other prism.
- an axis of symmetry (shown as vertical) of the divot 3271 D is generally coaxial with the axis of symmetry of the secondary needle seal 3271 .
- an axis of symmetry of the divot 3271 D is generally coaxial with the axis of symmetry of the needle 260 .
- the divot 3271 D is configured to accept and/or align the needle 260 . In some embodiments, the divot 3271 D is configured to direct the needle 260 away from compressed areas of the secondary needle seal 3271 . In some embodiments, one or more edges of the secondary needle seal 3271 are rounded.
- the boundary between the distal portion 3271 A and a first end of the mesial portion 3271 B forms a distal seal lip 3271 E that extends perpendicular to the axis of symmetry of the secondary needle seal 3271 .
- the boundary between the proximal portion 3271 A and a second end of the mesial portion 3271 B, opposite the first end forms a proximal seal lip 3271 F that extends perpendicular to the axis of symmetry of the secondary needle seal 3271 .
- the minimum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the distal portion 3271 A. In some embodiments, the maximum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the distal portion 3271 A. In some embodiments, the minimum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the proximal portion 3271 C. In some embodiments, the maximum outer diameter of the mesial portion 3271 B is less than a maximum outer diameter of the proximal portion 3271 C.
- the exemplary secondary needle sheath 3270 is configured to accept the secondary needle seal 3271 .
- the exemplary secondary needle sheath 3270 is configured to accept the secondary needle seal 3271 such that a gap 3201 exists between the exemplary secondary needle sheath 3270 and the mesial portion 3721 A of the secondary needle seal 3271 .
- the gap 3201 allows the secondary needle seal 3271 to expand when the needle 260 is inserted therethrough.
- the gap 3201 enables the secondary needle sheath 3270 to securely retain the secondary needle seal 3271 with minimal radial compression.
- reduced radial compression prevents coring of the secondary needle seal 3271 .
- the gap 3201 enables air to permeate out of the secondary needle sheath 3270 and around at least a portion of the secondary needle seal 3271 .
- the gap 3201 allows the secondary needle seal 3271 to expand when the needle 260 is inserted therethrough, to prevent coring of the secondary needle seal 3271 .
- a distal surface of the secondary needle sheath 3270 is flattened to form a distal sheath seal lip 3270 F that mates with the distal seal lip 3271 E of the secondary needle seal 3271 .
- the secondary needle sheath 3270 comprises a proximal sheath seal lip 3270 F, that mates with the proximal seal lip 3271 F of the of the secondary needle seal 3271 .
- the distal sheath seal lip 3270 E and the proximal seal lip 3271 F at least partially constrain translational and/or rotational movement of the secondary needle seal 3271 with in the secondary needle sheath 3270 .
- the second injector system 800 further comprises a collar 940 , a plunger attachment sleeve 930 , and a collar sleeve 920 .
- the collar sleeve 920 couples to at least one of the needle housing 950 , the plunger attachment sleeve 930 , or the needle sheath 970 .
- the collar sleeve 920 couples to the needle sheath 970 by a snap.
- the collar sleeve 920 couples to the needle sheath 970 via a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof.
- the plunger attachment sleeve 930 couples to the needle housing, the collar sleeve 920 , or both by a snap.
- the plunger attachment sleeve 930 couples to the needle housing, the collar sleeve 920 , or both by a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof.
- a distal outer diameter of the plunger attachment sleeve 930 is greater than an inner diameter of the second cavity of the needle housing 950 . Also as shown, the plunger attachment sleeve 930 removably connects to the plunger housing 820 .
- the collar 940 couples to the collar sleeve 920 .
- the collar 940 when coupled to the collar sleeve 920 , prevents the needle sheath 970 from translating in a distal direction, a proximal direction or both.
- the collar 940 when decoupled from the collar sleeve 920 , allows the needle sheath 970 to translate in a distal direction, a proximal direction or both.
- the needle assembly 910 is in a sheathed state, per FIG. 10 , when the collar 940 is coupled to the collar sleeve 920 .
- the needle assembly 910 is in an unsheathed state, per FIG. 11 , when the collar 940 is decoupled from the collar sleeve 920 .
- the collar 940 couples to the collar sleeve 920 by rotating the collar 940 , translating the collar 940 , or both with respect to the collar sleeve 920 .
- the collar 940 decouples from the collar sleeve 920 by rotating the collar 940 , translating the collar 940 , or both with respect to the collar sleeve 920 .
- At least one of the push pin 990 , the needle housing 950 and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction ejects the (e.g., one or more) implant(s) 300 positioned inside the needle lumen out of the needle lumen and into the eye of the patient.
- at least one of the push pin 990 , the needle housing 950 and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction partially ejects the (e.g., one or more) implant(s) 300 out of the needle lumen.
- At least one of the push pin 990 , the needle housing 950 and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen. In some embodiments, at least one of the push pin 990 , the needle housing 950 and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more.
- At least one of the push pin 990 , the needle housing 950 , and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction positions a distal end of the push rod of the push pin 990 distal to the distal end of the needle 260 .
- at least one of the push pin 990 , the needle housing 950 , and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction positions a distal end of the push rod of the push pin 990 distal to the distal end of the needle 260 by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more.
- At least one of the push pin 990 , the needle housing 950 and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction positions a distal end of the push rod of the push pin 990 proximal to the distal end of the needle 260 .
- at least one of the push pin 990 , the needle housing 950 and the needle 260 is dimensioned such that translating the push pin 990 in a distal direction positions a distal end of the push rod of the push pin 990 proximal to the distal end of the needle 260 by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more.
- the needle 260 has a length such that the distal end of the needle 260 is within the needle seal when the needle assembly 910 is in a sheathed state. Further, as shown, at least a portion of the push rod of the push pin 990 is disposed within the needle 260 , and at least a portion of the push pin 990 is disposed within the needle housing 950 . As shown a distal portion of the push pin 990 is disposed within the needle 260 , and a proximal portion of the push pin 990 is disposed within the needle housing 950 .
- a proximal portion of the push pin 990 is disposed within the second cavity of the needle housing 950
- an intermediate portion of the push pin 990 is disposed within the first cavity of the needle housing 950
- the push pin 990 passes through the thru-hole of the needle housing 950 .
- a distal end of the needle 260 extends beyond the distal end of the needle housing 950 .
- a distal end of the needle 260 extends beyond the distal end of the needle housing 950 by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more.
- the push rod of the push pin 990 translates within the needle lumen.
- the push rod has an outer diameter of less than the inner diameter of the needle 260 .
- the head has an outer diameter greater than the inner diameter of the needle 260 .
- the head does not fit within the needle 260 .
- the push pin 990 is dimensioned and positioned in the needle lumen such that distal translating of the push pin 990 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen.
- the push pin 990 is dimensioned and positioned in the needle lumen such that distal translating of the push pin 990 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen. In some embodiments, the push pin 990 is dimensioned and positioned in the needle lumen such that distal translating of the push pin 990 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen into the eye of the patient.
- a distal surface of the push rod of the push pin 990 contacts the distal portion of the (e.g., one or more) implant(s) 300 during the sheathed state, the unsheathed state, or both of the needle assembly 910 . In some embodiments, a distal surface of the push rod of the push pin 990 contacts the distal portion of the (e.g., one or more) implant(s) 300 during a sheathed state of the device, an unsheathed state of the device, or both of the needle assembly 910 .
- the (e.g., one or more) implant(s) 300 have a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) 300 comprise a plurality of particles. In some embodiments, the (e.g., one or more) implant(s) 300 have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon.
- the needle 260 has a length such that the distal end of the needle 260 is within the needle seal when the needle assembly 910 is in a sheathed state. In some embodiments, the needle 260 has a length of about 5 mm to about 70 mm.
- the needle 260 has a length of about 5 mm to about 80 mm, about 5 mm to about 85 mm, about 5 mm to about 90 mm, about 5 mm to about 95 mm, about 5 mm to about 30 mm, about 5 mm to about 35 mm, about 5 mm to about 40 mm, about 5 mm to about 45 mm, about 5 mm to about 50 mm, about 5 mm to about 60 mm, about 5 mm to about 70 mm, about 80 mm to about 85 mm, about 80 mm to about 90 mm, about 80 mm to about 95 mm, about 80 mm to about 30 mm, about 80 mm to about 35 mm, about 80 mm to about 40 mm, about 80 mm to about 45 mm, about 80 mm to about 50 mm, about 80 mm to about 60 mm, about 80 mm to about 70 mm, about 85 mm to about 90 mm, about 85 mm to about 95 mm, about 85 mm to about 30 mm, about 80 mm to
- the needle 260 has a length of about 5 mm, about 80 mm, about 85 mm, about 90 mm, about 95 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm. In some embodiments, the needle 260 has a length of at least about 5 mm, about 80 mm, about 85 mm, about 90 mm, about 95 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, or about 60 mm.
- the needle 260 has a length of at most about 80 mm, about 85 mm, about 90 mm, about 95 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm.
- the length of the needle 260 is a maximum length, a minimum length, a normal length, or an average length.
- the second injector system 800 comprises a plunger housing 820 , a plunger 830 , and a compression spring 840 .
- the plunger 830 is slidably disposed within the plunger housing 820 .
- a distal end of the plunger 830 is adapted to engage and push the push pin 990 of the needle assembly 910 when in a distal position within the plunger housing 820 .
- the distal end of the plunger 830 engages the head of the push pin 990 of the needle assembly 910 .
- the plunger 830 is manually actuated to translate distally within the plunger housing 820 .
- the plunger housing 820 is a syringe barrel.
- the syringe barrel is a 1 mL syringe barrel.
- a proximal end of the syringe plunger 830 protrudes beyond the plunger housing 820 .
- the plunger 830 is mechanically actuated to translate distally within the plunger housing 820 .
- the plunger assembly 810 further comprises a compression spring 840 biasing the plunger 830 towards a proximal end of the plunger housing 820 .
- the compression spring 840 has a distal end connected to the plunger housing 820 and a proximal end connected to the plunger 830 .
- the plunger 830 comprises a first stop feature 831 , wherein the plunger housing 820 comprises a second stop 821 822 823 feature engageable with the first stop feature 831 .
- the second stop feature comprises a primary second stop 821 and a secondary second stop 822 .
- the second stop feature comprises a primary second stop 821 , a secondary second stop 822 , and a tertiary second stop 823 .
- the second stop feature does not comprise the tertiary second stop 823 .
- the primary second stop 821 engages with the first stop feature 831 in the sheathed state of the needle assembly 910 .
- the secondary second stop 822 engages with the first stop feature 831 in the unsheathed state of the needle assembly 910 .
- the first stop feature 831 engages with the secondary second stop 822 in a first extended position of the plunger assembly 810 .
- the first stop feature 831 engages with the tertiary stop 823 in a second extended position of the plunger assembly 810 .
- the injector system 800 ejects a first implant 300 in the first extended position, and ejects a second implant 300 in the second extended position.
- the primary second stop 821 engages with the first stop feature 831 in the sheathed state of the needle assembly 910 or the first extended position, wherein upon implantation, distal force on the plunger advances the first stop feature 831 past the secondary second stop 822 by a retraction distance, whereafter reduction or release of the distal force returns the first stop feature 831 proximally by the retraction distance to engage with the secondary second stop 822 .
- the first stop feature 831 engages with the tertiary second stop 823 in the second extended position of the plunger assembly 810 , wherein upon implantation, distal force on the plunger advances the first stop feature 831 past the tertiary second stop 823 by a retraction distance, whereafter reduction or release of the distal force returns the first stop feature 831 proximally by the retraction distance to engage with the tertiary second stop 823 .
- the first stop feature 831 comprises a flexure, wherein the primary second stop 821 and the secondary second stop 822 comprise a slot.
- the first stop feature 831 comprises a snap, a detent, a spring, a clip, or any combination thereof.
- the primary second stop 821 and the secondary second stop 822 comprise a snap, a detent, a spring, a clip, or any combination thereof.
- the secondary second stop 822 is distal to the primary second stop 821 .
- a distance between the primary second stop 821 and the secondary second stop 822 determines the distance that the plunger translates from the sheathed state to the unsheathed state of the needle assembly 910 .
- a distance between the primary second stop 821 and the secondary second stop 822 determines the distance that the push pin 990 translates.
- a distance between the primary second stop 821 and the secondary second stop 822 determines the distance that the (e.g., one or more) implant(s) 300 translate. In some embodiments, a distance between the primary second stop 821 and the secondary second stop 822 minus the length of the (e.g., one or more) implant(s) 300 determines the distance that the (e.g., one or more) implant(s) 300 is deposited into the eye of a subject.
- FIGS. 16 - 19 show illustrations of an exemplary injector system 1600 comprising a biopsy punch 1610 .
- the biopsy punch 1610 comprises a modified biopsy punch formed from a commercially available biopsy punch.
- the biopsy punch injector system 1600 comprises a commercially available needle 1620 and a sheath 1670 surrounding at least a portion of the needle 1620 .
- the biopsy punch injector system 1600 comprises a push pin 1690 coupled to a distal surface of the biopsy punch 1610 .
- one or more implantable medicaments is contained within the needle 1620 .
- distal translation of the biopsy punch 1610 translates the push pin 1690 to eject one or more implantable medicaments out of the needle 1620 .
- the needle 1620 has a gauge of 20 to 40. In some embodiments, the needle 1620 has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40.
- the needle 1620 has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle 1620 has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, the needle 1620 has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle 1620 has a gauge of 23 to 30. In some embodiments, the needle 1620 has a gauge of 23. In some embodiments, the needle 1620 has a gauge of 30. In some embodiments, the needle 1620 is straight. In some embodiments, the needle 1620 is curved.
- the curved needle 1620 has a curvature radius of about 10, 20, 30, 40, 50, 60, 70, 80, 90 mm or more. In some embodiments, the needle 1620 is twisted. In some embodiments, the twisted needle 1620 has a pitch of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more. In some embodiments, the twisted needle 1620 has a maximum outer diameter of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more.
- FIG. 19 shows an exemplary injector system 1600 comprising a biopsy punch 1610 and a retractable needle seal housing 1650 .
- the retractable needle seal housing 1650 is slidably coupled to the needle 1620 . Further as shown, the retractable needle seal housing 1650 translates with respect to the needle 1620 between a sheathed state and an unsheathed state. Further, as shown the retractable needle seal housing 1650 comprises a flange for manipulation of the system 1600 , and a needle seal 1671 . In some embodiments, the retractable needle seal housing 1650 comprises a needle seal 1671 that surrounds the distal end of the needle 1620 when the system 1600 is in the sheathed state.
- the distal end of the needle 1620 is distal to the distal face of the distal plug of the needle seal 1671 when the system 1600 is in an unsheathed state. Additionally, as shown, the sheath 1670 removably attaches to the retractable needle seal housing 1650 .
- the needle seal 1671 of the retractable needle seal housing 1671 is made of silicone, plastic, or any other medical grade material.
- FIGS. 20 - 24 show exemplary injector systems comprising a syringe 2010 .
- the injector system 2000 comprises the syringe 2010 , a needle 1620 , a sheath 1670 surrounding at least a portion of the needle 1620 , and a retractable needle seal 1670 slidably coupled to the needle 1620 .
- the syringe 2010 comprises a 1 ml syringe.
- the syringe 2010 comprises a commercially available syringe.
- injector system 2000 comprises a push pin 1690 coupled to a distal surface of the syringe 2010 .
- one or more implantable medicaments is contained within the needle 1620 .
- distal translation of the syringe 2010 translates the push pin 1690 to eject one or more implantable medicaments out of the needle 1620 .
- the sheath 1670 and the retractable needle seal 1671 of the injector system 2000 are a single retainer sheath component 2150 , which extends proximally beyond the needle 1620 .
- the retainer sheath component 2150 provides an airtight seal against the syringe 2010 .
- FIG. 22 shows illustrations of an exemplary injector system 2200 comprising a needle 2260 and removable needle seal assembly 2250 in a sheathed state (left) and an unsheathed state (right).
- the shape of the outer surface of the hub of the needle 2260 serves as a rail.
- the rail has longitudinal bearing surfaces parallel to the retraction direction of the removable needle seal assembly.
- the longitudinal bearing surface is either formed of ridges or has a cylindrical cross-sectional shape.
- the longitudinal bearing surface enables retraction of the needle seal assembly.
- the longitudinal bearing surface constrains against extension and retraction in directions other than parallel to the longitudinal needle lumen axis.
- the longitudinal bearing surface enables linear retraction of the removable needle seal assembly to reduce bending loads on the needle 2260 .
- FIG. 23 shows an illustration of another exemplary injector system 2300 comprising a latching retainer sheath component 2350 that latches about and on to the syringe 2010 .
- the latching retainer sheath component 2350 couples to the syringe 2010 by a flexure and a clip.
- the latching retainer sheath component 2350 couples to the syringe 2010 by a hinge, a screw, a nut, a slide, a clamp, a bolt, a tie, or any combination thereof. Further, per FIGS.
- the exemplary injector system 2300 further comprises a removable push pin retainer 2390 that prevents movement of the latching retainer sheath component 2350 with respect to the needle 1620 , when engaged.
- the removable push pin retainer 2390 removably couples the latching retainer sheath component 2350 to a side wall of the needle 1620 .
- the removable push pin retainer 2390 comprises a pin, a tie, a clip, a flexure, a switch, or any combination thereof. Further, per FIG.
- the exemplary injector system 2300 further a commercially available syringe, comprising a distal plunger protrusion that advances the push pin 1690 and an anti-buckling constraint 2410 that constrains the proximal push pin head within a linear path at a fixed angle parallel to the needle lumen axis.
- the anti-buckling constraint 2410 prevents the push pin 1690 from buckling during plunger, push wire, and implant advancement.
- the sheath interface 2420 enables easier insertion of the sheath 1650 over the needle 1620 and linear retraction of the sheath over the needle.
- FIGS. 25 shows a perspective cross-sectioned illustration of an exemplary third injector system.
- an outer surface of the plunger housing has a surface treatment to improve grip.
- FIGS. 26 - 29 show front view illustrations of exemplary plungers of the third injector system.
- FIGS. 30 - 31 show front cross-sectioned and detailed view illustrations of an exemplary plunger housing of the third injector system.
- first injector system the first injector system, the second injector system, the third injector system, and any other injector system or component described here can be used in combination with, or interchangeably between systems.
- first injector system, the second injector system, the third injector system, and any other injector system described here employ the needle seal, the needle sheath the secondary needle seal, the secondary needle sheath, or any combination thereof.
- an injector system comprising: a needle sheath; and a needle seal secured within at least a portion of the needle sheath.
- at least a portion of the needle seal and the needle sheath are separated by a gap.
- the portion of the needle seal is a mesial portion of the needle seal.
- the portion of the needle seal is the portion secured within the needle sheath.
- at least a distal portion of the needle seal extends beyond at least a distal portion of the needle sheath.
- the needle seal is within a distal portion of the needle sheath. In some embodiments, the needle seal is molded within a distal portion of the needle sheath. In some embodiments, the needle seal is adhered or coupled to a distal portion of the needle sheath. In some embodiments, the needle seal is formed of a polymer. In some embodiments, the polymer is rubber, plastic, or both. In some embodiments, the needle seal is removable.
- At least a distal portion of the needle seal seals at least a portion of a needle. In some embodiments, at least a distal portion of the needle seal seals at least a bevel of a needle. In some embodiments, at least a distal portion of the needle seal seals at least a majority of a bevel of a needle. In some embodiments, the needle seal is configured to seal an (e.g., one or more) implant(s) within a needle.
- the needle seal comprises a distal portion, a proximal portion, and a mesial portion between the distal portion and the proximal portion.
- the needle seal is axisymmetric.
- an outer surface of the distal portion is generally convex.
- an outer surface of the mesial portion is generally in the form of a conical frustum.
- the outer surface of the proximal portion is generally cylindrical.
- a bottom surface of the needle seal on the proximal portion comprises a divot. In some embodiments, the divot is conical.
- the divot is cylindrical, a conical frustum, or any other prism.
- an axis of symmetry of the divot is generally coaxial with the axis of symmetry of the needle seal.
- the divot is configured to accept and/or align a needle.
- the divot is configured to direct a needle away from compressed areas of the needle seal.
- one or more edges of the needle seal are rounded.
- the boundary between the distal portion and a first end of the mesial portion forms a distal seal lip that extends perpendicular to the axis of symmetry of the needle seal. In some embodiments, the boundary between the proximal portion and a second end of the mesial portion, opposite the first end, forms a proximal seal lip that extends perpendicular to the axis of symmetry of the needle seal.
- the minimum outer diameter of the mesial portion is less than a maximum outer diameter of the distal portion. In some embodiments, the maximum outer diameter of the mesial portion is less than a maximum outer diameter of the distal portion. In some embodiments, the minimum outer diameter of the mesial portion is less than a maximum outer diameter of the proximal portion. In some embodiments, the maximum outer diameter of the mesial portion is less than a maximum outer diameter of the proximal portion.
- the exemplary needle sheath is configured to accept the needle seal. In some embodiments, the exemplary needle sheath is configured to accept the needle seal such that a gap exists between the needle sheath and the mesial portion of the needle seal. In some embodiments, the gap allows the needle seal to expand when the needle is inserted therethrough. In some embodiments, the gap enables the needle sheath to securely retain the needle seal with minimal radial compression. In some embodiments, reduced radial compression prevents coring of the needle seal. In some embodiments, the gap enables air to permeate out of the needle sheath and around at least a portion of the needle seal.
- the gap allows a needle seal to expand when the needle is inserted therethrough, to prevent coring of the needle seal.
- a distal surface of the needle sheath is flattened to form a distal sheath seal lip that mates with the distal seal lip of the needle seal.
- the needle sheath comprises a proximal sheath seal lip, that mates with the proximal seal lip of the of the needle seal.
- the distal sheath seal lip and the proximal seal lip at least partially constrain translational and/or rotational movement of the needle seal with in the needle sheath.
- Another aspect provided herein is a method for injecting an (e.g., one or more) implant(s) into an eye of a patient, wherein the method comprises: providing an injector system and injecting the (e.g., one or more) implant(s) into the eye of the patient.
- the system for injecting an (e.g., one or more) implant(s) into an eye of a patient has an unsheathed state and a sheathed state.
- the system for injecting an (e.g., one or more) implant(s) into an eye of a patient comprises a needle assembly and a plunger assembly removably coupled to the needle assembly.
- the needle assembly comprises a needle housing, a needle, and a needle lumen, the (e.g., one or more) implant(s) inside the needle lumen, and a push pin at least partially disposed within the needle lumen.
- the plunger assembly comprises: a plunger housing and a plunger slidably disposed within the plunger housing.
- injecting the (e.g., one or more) implant(s) into the eye of the patient comprises translating the plunger within the plunger housing to engage the push pin and translate the push pin within the needle such that a distal surface of the needle contacts the (e.g., one or more) implant(s) and translates the (e.g., one or more) implant(s) out of the needle and into the eye of the patient.
- the needle housing is received with the (e.g., one or more) implant(s) and within the needle.
- a technician or medical practitioner then attaches the needle housing to the plunger assembly.
- the medical practitioner unsheathes the needle assembly and inserts the needle into the eye of the patient until the distal portion of the needle sheath abuts against the eye of the patient.
- the technician then applies a distal force to the plunger to decouple the first stop feature from the primary second stop feature.
- the distal force distally translates the plunger such that distal portion of the plunger distally translates the push pin, which translates the (e.g., one or more) implant(s) within the needle into the eye of the patient.
- biopsy punch refers to a sharp, hollow, circular instrument for extracting a round piece of tissue.
- proximal refers to a direction towards the user of the device and away from the patient.
- distal refers to a direction away from the user of the device and towards the patient.
- the term “lumen” refers to the hollow portion of a needle in which a medicament is transferred.
- the term “about” refers to an amount that is near the stated amount by 10%, 5%, or 1%, including increments therein.
- the term “about” in reference to a percentage refers to an amount that is greater or less the stated percentage by 10 %, 5 %, or 1 %, including increments therein.
- each of the expressions “at least one of A, B and C”, “at least one of A, B, or C”, “one or more of A, B, and C”, “one or more of A, B, or C” and “A, B, and/or C” means A alone, B alone, C alone, A and B together, A and C together, B and C together, or A, B and C together.
Abstract
Description
- This application claims the benefit U.S. Provisional Application No. 62/924,116, filed Oct. 21, 2019 which is hereby incorporated by reference in its entirety herein.
- Ocular injection of solid or particulate medicament must be precise and accurate for proper treatment and prevention of further damage to the eye.
- One aspect provided herein is an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a plunger assembly comprising: a plunger housing; and a plunger slidably disposed within the plunger housing, wherein a distal end of the plunger being engaged with a push pin of the needle assembly when in a distal position within the plunger housing; and a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the needle lumen being configured to receive an (e.g., one or more) implant(s) positioned therewithin; and the push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the (e.g., one or more) implant(s) from the needle lumen and into the eye of the patient.
- In some embodiments, the needle assembly further comprises a needle sheath and a needle seal secured by the needle sheath, wherein the distal end of the needle lumen is within and sealed by the needle seal when the system is in the sheathed state, and wherein the distal end of the needle extends beyond the needle seal when the system is in the unsheathed state. In some embodiments, a distal surface of the needle seal is pierced by translating the needle sheath in a proximal direction. In some embodiments, the needle has a length such that the distal end of the needle is within the needle seal when the system is in a sheathed state. In some embodiments, at least a portion of the needle seal and the needle sheath are separated by a gap. In some embodiments, the portion of the needle seal is a mesial portion of the needle seal. In some embodiments, at least a distal portion of the needle seal extends beyond at least a distal portion of the needle sheath. In some embodiments, the injector system further comprises the implant in the needle lumen between the push pin and the seal. In some embodiments, the distal end of the plunger engages the head of the push pin. In some embodiments, the plunger is manually actuated to translate distally within the plunger housing. In some embodiments, a proximal end of the plunger assembly protrudes beyond the plunger housing. In some embodiments, the plunger is mechanically actuated to translate distally within the plunger housing. In some embodiments, the plunger assembly further comprises a compression spring biasing the plunger towards a proximal end of the plunger housing. In some embodiments, the compression spring has a distal end connected to the plunger housing and a proximal end connected to the plunger. In some embodiments, the plunger comprises a first stop feature, wherein the plunger housing comprises a second stop feature engageable with the first stop feature. In some embodiments, the second stop feature comprises a primary second stop and a secondary second stop. In some embodiments, the needle assembly further comprises a resilient member disposed within the needle housing. In some embodiments, the resilient member proximally biases the push pin. In some embodiments, the needle assembly further comprises a needle sheath having a proximal portion surrounding the distal end of the needle housing, and a distal portion surrounding the distal end of the needle. In some embodiments, the needle sheath is removable from the needle housing by translating in a distal direction away from the needle housing to expose the needle. In some embodiments, the needle sheath translates proximally to the unsheathed state where the distal end of the needle extends beyond the distal portion of the needle sheath.
- Another aspect provided herein is a needle assembly for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the (e.g., one or more) implant(s) from the needle lumen and into the eye of the patient.
- In some embodiments, the needle assembly further comprises a needle sheath having a seal, wherein the distal end of the needle lumen is within and sealed by the needle seal when the system is in the sheathed state, and wherein the distal end of the needle extends beyond the needle seal when the system is in the unsheathed state. In some embodiments, the needle assembly further comprises a resilient member disposed within the needle housing. In some embodiments, the resilient member proximally biases the push pin. In some embodiments, the resilient member is a spring, a flexure, a piston, a motor, a band, or any combination thereof. In some embodiments, the needle assembly further comprises a needle sheath having a proximal portion surrounding the distal end of the needle housing, and a distal portion surrounding the distal end of the needle. In some embodiments, the needle sheath is pierced by the needle by translating in a distal direction away from the needle housing to expose the needle. In some embodiments, the needle sheath translates proximally to the unsheathed state where the distal end of the needle extends beyond the distal portion of the needle sheath. In some embodiments, the distal portion of the needle sheath abuts the eye of the patient when the (e.g., one or more) implant(s) is ejected from the needle lumen. In some embodiments, the needle assembly further comprises a needle seal at the distal end of the needle that seals the distal end of the needle lumen. In some embodiments, needle seal is within a distal portion of the needle sheath. In some embodiments, the needle seal is formed of a polymer. In some embodiments, the needle seal is pierced by translating the needle sheath in a proximal direction. In some embodiments, the needle has a length such that the distal end of the needle is within the needle seal when the system is in a sheathed state. In some embodiments, the needle assembly further comprises a removable push pin retainer that prevents movement of the needle housing relative to the needle sheath when engaged. In some embodiments, the removable push pin retainer removably couples the push pin to the needle housing. In some embodiments, the removable push pin retainer removably couples the needle housing to a side wall of the needle sheath. In some embodiments, the (e.g., one or more) implant(s) are loaded in the needle lumen between the distal end of the push pin and the distal end of the needle. In some embodiments, the (e.g., one or more) implant(s) have a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) comprise a plurality of particles. In some embodiments, the (e.g., one or more) implant(s) have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon. In some embodiments, the needle has a gauge of 20 to 40. In some embodiments, the needle has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40. In some embodiments, the needle has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, the needle has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of 23 to 30. In some embodiments, the needle has a gauge of 23. In some embodiments, the needle has a gauge of 30. In some embodiments, the needle is straight. In some embodiments, the needle is curved.
- Another aspect provided herein is an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a plunger assembly comprising: a plunger housing; and a plunger slidably disposed within the plunger housing, wherein a distal end of the plunger engages the push pin of the needle assembly when in a distal position within the plunger housing; and the needle assembly
- In some embodiments, the distal end of the plunger engages the head of the push pin. In some embodiments, the plunger is manually actuated to translate distally within the plunger housing. In some embodiments, the plunger housing is a syringe barrel. In some embodiments, the syringe barrel is a 1 mL syringe barrel. In some embodiments, the plunger housing is a biopsy punch. In some embodiments, a proximal end of the syringe plunger protrudes beyond the plunger housing. In some embodiments, the plunger is mechanically actuated to translate distally within the plunger housing. In some embodiments, the plunger assembly further comprises a compression spring biasing the plunger towards a proximal end of the plunger housing. In some embodiments, the compression spring has a distal end connected to the plunger housing and a proximal end connected to the plunger. In some embodiments, the plunger comprises a first stop feature, wherein the plunger housing comprises a second stop feature engageable with the first stop feature. In some embodiments, the second stop feature comprises a primary second stop and a retracted second stop.
- Another aspect provided herein is an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a plunger assembly comprising: a plunger housing; and a plunger slidably disposed within the plunger housing, wherein a distal end of the plunger engages the push pin of the needle assembly when in a distal position within the plunger housing; and a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the (e.g., one or more) implant(s) from the needle lumen and into the eye of the patient.
- In some embodiments, the distal end of the plunger engages the head of the push pin. In some embodiments, the plunger is manually actuated to translate distally within the plunger housing. In some embodiments, the plunger housing is a syringe barrel. In some embodiments, the syringe barrel is a 1 mL syringe barrel. In some embodiments, the plunger housing is a biopsy punch. In some embodiments, a proximal end of the syringe plunger protrudes beyond the plunger housing. In some embodiments, the plunger is mechanically actuated to translate distally within the plunger housing. In some embodiments, the plunger assembly further comprises a compression spring biasing the plunger towards a proximal end of the plunger housing. In some embodiments, the compression spring has a distal end connected to the plunger housing and a proximal end connected to the plunger. In some embodiments, the plunger comprises a first stop feature, wherein the plunger housing comprises a second stop feature engageable with the first stop feature. In some embodiments, the second stop feature comprises a primary second stop and a secondary second stop. In some embodiments, the needle assembly further comprises a resilient member disposed within the needle housing. In some embodiments, the resilient member proximally biases the push pin. In some embodiments, the resilient member is a spring, a flexure, a piston, a motor, a band, or any combination thereof. In some embodiments, the needle assembly further comprises a needle sheath having a proximal portion surrounding the distal end of the needle housing, and a distal portion surrounding the distal end of the needle. In some embodiments, the needle sheath is removable from the needle housing by translating in a distal direction away from the needle housing to expose the needle. In some embodiments, the needle sheath translates proximally to the unsheathed state where the distal end of the needle extends beyond the distal portion of the needle sheath. In some embodiments, the distal portion of the needle sheath abuts the eye of the patient when the (e.g., one or more) implant(s) are ejected from the needle lumen. In some embodiments, the injector system further comprises a needle seal at the distal end of the needle that seals the distal end of the needle lumen. In some embodiments, the needle seal is within a distal portion of the needle sheath. In some embodiments, the needle seal is formed of a polymer. In some embodiments, the needle seal is pierced by the needle by translating the needle sheath in a proximal direction. In some embodiments, the needle has a length such that the distal end of the needle is within the needle seal when the system is in a sheathed state. In some embodiments, the needle assembly further comprises a removable push pin retainer that prevents movement of the needle housing relative to the needle sheath when engaged. In some embodiments, the removable push pin retainer removably couples the push pin to the needle housing. In some embodiments, the removable push pin retainer removably couples the needle housing to a side wall of the needle sheath. In some embodiments, the (e.g., one or more) implant(s) are loaded in the needle lumen between the distal end of the push pin and the distal end of the needle. In some embodiments, the (e.g., one or more) implant(s) have a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) comprise a plurality of particles. In some embodiments, the (e.g., one or more) implant(s) have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon. In some embodiments, the needle has a gauge of 20 to 40. In some embodiments, the needle has a gauge of 20 to 40. In some embodiments, the needle has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40. In some embodiments, the needle has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, the needle has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, the needle has a gauge of 23 to 30. In some embodiments, the needle has a gauge of 23. In some embodiments, the needle has a gauge of 30. In some embodiments, the needle is straight. In some embodiments, the needle is curved.
- Another aspect provided herein is an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) are positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the (e.g., one or more) implant(s) from the needle lumen and into the eye of the patient; and a plunger assembly removably coupled to the needle assembly, wherein the plunger assembly comprises: a plunger housing; and a plunger slidably disposed within the plunger housing, wherein a distal end of the plunger engages the push pin of the needle assembly when in a distal position within the plunger housing.
- Another aspect provided herein is a method for injecting an (e.g., one or more) implant(s) into an eye of a patient, wherein the method comprises: providing an injector system for injecting an (e.g., one or more) implant(s) into an eye of a patient having an unsheathed state and a sheathed state, the system comprising: a needle assembly comprising: a needle housing having a proximal end and a distal end; a needle having a proximal end attached to the distal end of the needle housing or within the needle housing, a distal end extending beyond the distal end of the needle housing, and a needle lumen at the distal end of the needle; the (e.g., one or more) implant(s) positioned inside the needle lumen; and a push pin having a head and a push rod, wherein a distal end of the push rod is disposed within the needle lumen, and wherein translating the push pin in a distal direction ejects the (e.g., one or more) implant(s) from the needle lumen and into the eye of the patient; and a plunger assembly removably coupled to the needle assembly, wherein the plunger assembly comprises: a plunger housing; and a plunger slidably disposed within the plunger housing; and engaging a distal end of the plunger with the push pin of the needle assembly to inject the (e.g., one or more) implant(s) into the eye of the patient.
- Another aspect provided herein is an injector system comprising: a needle sheath; and a needle seal secured within at least a portion of the needle sheath. In some embodiments, at least a portion of the needle seal and the needle sheath are separated by a gap. In some embodiments, the portion of the needle seal is a mesial portion of the needle seal. In some embodiments, the portion of the needle seal is the portion secured within the needle sheath. In some embodiments, at least a distal portion of the needle seal extends beyond at least a distal portion of the needle sheath.
- The novel features of the disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the disclosure are utilized, and the accompanying drawings of which:
-
FIG. 1 shows a perspective illustration of an exemplary first injector system in a sheathed state, per some embodiments herein; -
FIG. 2 shows a perspective illustration of an exemplary first injector system in an unsheathed state, per some embodiments herein; -
FIG. 3 shows an exploded perspective illustration of an exemplary first injector system, per some embodiments herein; -
FIG. 4 shows a cross-sectional illustration of an exemplary first injector system in a sheathed state, per some embodiments herein; -
FIG. 5 shows a cross-sectional illustration of an exemplary first injector system in an unsheathed state, per some embodiments herein; -
FIG. 6 shows a detailed cross-sectional illustration of a needle assembly of the exemplary first injector system, per some embodiments herein; -
FIG. 7 shows a detailed cross-sectional illustration of a plunger assembly of the exemplary first injector system, per some embodiments herein; -
FIG. 8 shows a perspective illustration of an exemplary second injector system in a sheathed state, per some embodiments herein; -
FIG. 9 shows a perspective illustration of an exemplary second injector system in an unsheathed state, per some embodiments herein; -
FIG. 10 shows a cross-sectional illustration of an exemplary second injector system in a sheathed state, per some embodiments herein; -
FIG. 11 shows a cross-sectional illustration of an exemplary second injector system in an unsheathed state, per some embodiments herein; -
FIG. 12 shows a perspective illustration of a plunger assembly of an exemplary second injector system, per some embodiments herein; -
FIG. 13 shows a cross-sectioned perspective illustration of a plunger assembly of an exemplary second injector system, per some embodiments herein; -
FIG. 14 shows a perspective illustration of a needle assembly of an exemplary second injector system, per some embodiments herein; -
FIG. 15 shows a cross-sectioned perspective illustration of a needle assembly of an exemplary second injector system, per some embodiments herein; -
FIG. 16 shows a front view illustration of an exemplary injector system comprising a biopsy punch, per some embodiments herein; -
FIGS. 17A-B show a front cross-sectioned view illustration of the exemplary injector system comprising a biopsy punch, per some embodiments herein; -
FIG. 18 shows an exploded illustration of the exemplary injector system comprising a biopsy punch, per some embodiments herein; -
FIG. 19 shows an exploded illustration of an exemplary injector system comprising a biopsy punch and a retractable needle seal, per some embodiments herein; -
FIG. 20 shows exploded and cross-sectioned illustrations of an exemplary injector system comprising a syringe and a retractable needle seal, per some embodiments herein; -
FIG. 21 shows an illustration of an exemplary injector system comprising a biopsy punch within a syringe or other full-length tube, per some embodiments herein; -
FIG. 22 shows illustrations of an exemplary injector system comprising a syringe and a primary needle and removable needle seal assembly in an unsheathed and a sheathed state, per some embodiments herein; -
FIG. 23 shows illustrations of an exemplary injector system comprising a syringe and a secondary needle and removable needle seal assemblies, per some embodiments herein; -
FIG. 24 shows an illustration of an exemplary injector system comprising a syringe and a removable push pin retainer, per some embodiments herein; -
FIG. 25 shows a perspective cross-sectioned illustration of an exemplary third injector system, per some embodiments herein; -
FIG. 26 shows front view illustrations of exemplary plungers of the third injector system, per some embodiments herein; -
FIG. 27 shows a first set detailed front view illustrations of exemplary plungers of the third injector system, per some embodiments herein; -
FIG. 28 shows a second set detailed front view illustrations of exemplary plungers of the third injector system, per some embodiments herein; -
FIG. 29 shows a third set detailed front view illustrations of exemplary plungers of the third injector system, per some embodiments herein; -
FIG. 30 shows front cross-sectioned view illustrations of an exemplary plunger housing of the third injector system, per some embodiments herein; -
FIG. 31 shows a fourth detailed front view illustration of an exemplary plunger of the third injector system, per some embodiments herein; -
FIG. 32A shows a front cross-sectioned view illustration of an exemplary secondary needle seal, per some embodiments herein; -
FIG. 32B shows a front-top perspective view illustration of an exemplary secondary needle seal, per some embodiments herein; -
FIG. 32C shows a front plan view illustration of an exemplary secondary needle seal, per some embodiments herein; -
FIG. 33A shows a front cross-sectioned view illustration of an exemplary secondary needle sheath and an exemplary secondary needle seal, per some embodiments herein; -
FIG. 33B shows a front cross-sectioned view illustration of an exemplary secondary needle sheath and an exemplary secondary needle seal being pierced by a needle, per some embodiments herein; -
FIG. 34A shows illustrations of two exemplary implants loaded in parallel into an exemplary needle, per some embodiments herein; and -
FIG. 34B shows illustrations of two exemplary implants loaded in series into an exemplary needle, per some embodiments herein. -
- There is currently an unmet need for devices that precisely and accurately intravitreally inject solid or particulate implants. Particularly a device that is simple and intuitive to operate and relies on the clinician-familiar syringe mechanism. Further, there is an unmet need for a device that affords the versatility of employing a variety of needle assemblies based on the (e.g., one or more) implant(s) sizes and/or the needle diameter. Finally, there is a need for a device that is economical to manufacture and whose reusability reduces its environmental impact.
- Provided herein per
FIGS. 1-7 is afirst injector system 100 for injecting an (e.g., one or more) implant(s) 300 into an eye of a patient, thesystem 100 comprising aneedle assembly 210 and aplunger assembly 110. As shown inFIG. 3 , theneedle assembly 210 removably couples to a distal end of theplunger assembly 110. In some embodiments, theneedle assembly 210 removably couples to a distal end of theplunger assembly 110 by a snap, a screw, a pin, a band, a clamp, or any combination thereof. Alternatively, in some embodiments, theneedle assembly 210 permanently couples to theplunger assembly 110. In some embodiments, theneedle assembly 210 is maneuverable between a sheathed state and an unsheathed state.FIG. 1 shows a sheathed state of theneedle assembly 210, andFIG. 2 shows an unsheathed state of theneedle assembly 210. In some embodiments, theplunger assembly 110 is maneuverable between an extended position and a retracted position. - As seen per
FIGS. 4-6 theexemplary needle assembly 210 comprises aneedle housing 250, aneedle 260, and apush pin 290. In some embodiments, theneedle assembly 210 further comprises the (e.g., one or more) implant(s) 300 loaded in theneedle 260. In some embodiments, theneedle assembly 210 further comprises the (e.g., one or more) implant(s) 300 loaded in a lumen of theneedle 260. In some embodiments, perFIG. 34A , the (e.g., one or more) implant(s) 300 comprise afirst implant 300A and asecond implant 300B, wherein thefirst implant 300A and thesecond implant 300B are loaded in parallel into theneedle 260. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such that their longitudinal axes of symmetry are within about 10 degrees of parallel. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such that their longitudinal axes of symmetry at least partially overlap. In some embodiments, perFIG. 34B , thefirst implant 300A and thesecond implant 300B are sequentially loaded in series into theneedle 260. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such that their longitudinal axes of symmetry are within about 10 degrees of being coaxial. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such a proximal point of thefirst implant 300A contacts a distal point of thesecond implant 300B. In some embodiments, thefirst implant 300A and thesecond implant 300B are ejected from theneedle 260 simultaneously. In some embodiments, thefirst implant 300A and thesecond implant 300B are ejected from theneedle 260 in series. In some embodiments, thefirst implant 300A and thesecond implant 300B are embedded in a solid or liquid media that maintains a set distance between one or more of their surfaces. - As shown, the
needle housing 250 has a proximal end and a distal end. Further, as shown, theneedle housing 250 comprises a male luer taper, a thru-hole, a first cavity, and a second cavity. Alternatively, in some embodiments, theneedle housing 250 does not comprise one or more of the male luer taper, the thru-hole, the first cavity, and the second cavity. In some embodiments, two or more of the male luer taper, the thru-hole, the first cavity, and the second cavity are concentric. As shown, a distal termination of the first cavity is distal to the distal termination of the male luer taper. As shown, a proximal termination of the first cavity is distal to the distal termination of the male luer taper. - As shown, the
needle 260 comprises a needle lumen at the distal end of theneedle 260 and a female luer taper at the proximal end of theneedle 260. Alternatively, in some embodiments, theneedle 260 does not comprise a female luer taper. In some embodiments, theneedle 260 has a gauge of 20 to 40. In some embodiments, theneedle 260 has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40. In some embodiments, theneedle 260 has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, theneedle 260 has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, theneedle 260 has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, theneedle 260 has a gauge of 23 to 30. In some embodiments, theneedle 260 has a gauge of 23. In some embodiments, theneedle 260 has a gauge of 30. In some embodiments, theneedle 260 is straight. In some embodiments, theneedle 260 is curved. In some embodiments, thecurved needle 260 has a curvature radius of about 10, 20, 30, 40, 50, 60, 70, 80, 90 mm or more. In some embodiments, theneedle 260 is twisted. In some embodiments, thetwisted needle 260 has a pitch of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more. In some embodiments, thetwisted needle 260 has a maximum outer diameter of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more. In some embodiments, theneedle 260 is a commerciallyavailable needle 260. - As shown in
FIGS. 4-6 theexemplary push pin 290 has a head and a push rod. Further, as shown, the head is positioned proximally to the push rod. As shown a proximal end of theneedle 260 is coupled to the distal end of theneedle housing 250 and thepush pin 290 is disposed within theneedle housing 250. Alternatively, in some embodiments, a proximal end of theneedle 260 is within theneedle housing 250. As shown, the push rod of thepush pin 290 has an outer diameter of less than the inner diameter of the thru-hole of theneedle housing 250. - As shown in
FIGS. 4-6 , theneedle assembly 210 further comprises aresilient member 280 disposed within theneedle housing 250. In some embodiments, theresilient member 280 proximally biases thepush pin 290. In some embodiments, theresilient member 280 proximally biases thepush pin 290 when theneedle assembly 210 is in a sheathed state. In some embodiments, theresilient member 280 proximally biases thepush pin 290 when theneedle assembly 210 is in an unsheathed state. As shown, theresilient member 280 is a spring. Alternatively, in some embodiments, theresilient member 280 is a flexure, a piston, a motor, a band, or any combination thereof. In some embodiments, theresilient member 280 is disposed within and constrained by the first cavity of theneedle housing 250. In some embodiments, theresilient member 280 has an outer diameter of less than an inner diameter of the first cavity of theneedle housing 250. As shown, the push rod of thepush pin 290 has an outer diameter of less than an inner diameter of theresilient member 280. - As shown in
FIGS. 4-6 , theneedle assembly 210 further comprises aneedle sheath 270 surrounding at least a portion of theneedle housing 250, and having a distal portion surrounding the distal end of theneedle 260. In some embodiments, a proximal portion of theneedle sheath 270 surrounds the distal end of theneedle housing 250. In some embodiments, a distal face of theneedle sheath 270 is more distal to theneedle housing 250 in the sheathed state of theneedle assembly 210 than in the unsheathed state of theneedle assembly 210. In some embodiments, a distal face of theneedle sheath 270 is more distal to theplunger housing 120 in the sheathed state of theneedle assembly 210 than in the unsheathed state of theneedle assembly 210. - In some embodiments, when the
needle assembly 210 is sheathed, theneedle 260 is entirely surrounded by theneedle sheath 270. In some embodiments, when theneedle assembly 210 is in the unsheathed state, at least a portion of theneedle 260 extends distally beyond theneedle sheath 270. In some embodiments, the distal portion of theneedle sheath 270 abuts the eye of the patient when the (e.g., one or more) implant(s) 300 are ejected from the needle lumen. In some embodiments, the distal portion of theneedle sheath 270 abuts the eye of the patient when theneedle assembly 210 is in its sheathed state. In some embodiments, the distal portion of theneedle sheath 270 abuts the eye of the patient when theneedle assembly 210 is in its unsheathed state. In some embodiments, the distal portion of theneedle sheath 270 abuts the eye of the patient when the needle lumen is within the eye of the patient. In some embodiments, the distal portion of theneedle sheath 270 abuts the eye of the patient when the needle lumen is within theneedle sheath 270. In some embodiments, theneedle sheath 270 is removable from theneedle housing 250. In some embodiments, theneedle sheath 270 is removable from theneedle housing 250 by translation of theneedle sheath 270 in a distal direction with respect to theneedle housing 250. In some embodiments, theneedle sheath 270 is removable from theneedle housing 250 by translation of theneedle sheath 270 in a proximal direction with respect to theneedle housing 250. - As shown in
FIGS. 4-6 , thefirst injector system 100 further comprises aneedle seal 271 at the distal end of theneedle 260 that seals the distal end of the needle lumen. In some embodiments, theneedle seal 271 is within a distal portion of theneedle sheath 270. In some embodiments, theneedle seal 271 is molded within a distal portion of theneedle sheath 270. In some embodiments, theneedle seal 271 is adhered or coupled to a distal portion of theneedle sheath 270. In some embodiments, theneedle seal 271 is formed of a polymer. In some embodiments, the polymer is rubber, plastic, or both. In some embodiments, theneedle seal 271 is removable. In some embodiments, translating theneedle sheath 270 in a proximal direction causes theneedle 260 to pierce theneedle seal 271. -
FIGS. 32A-32B show an exemplarysecondary needle seal 3271 and an exemplarysecondary needle sheath 3270. In some embodiments, at least a distal portion of theneedle 260 is sealed within thesecondary needle seal 3271. In some embodiments, at least a distal portion of the bevel of theneedle 260 is sealed within thesecondary needle seal 3271. In some embodiments, at least a majority of the bevel of theneedle 260 is sealed within thesecondary needle seal 3271. In some embodiments, at least the bevel of theneedle 260 is sealed within thesecondary needle seal 3271. In some embodiments, thesecondary needle seal 3271 seals an (e.g., one or more) implant(s) within thelumen needle 260. In some embodiments, at least a distal portion of theneedle 260 is sealed within thesecondary needle seal 3271 in the sheathed state of the injector system. In some embodiments, at least a distal portion of the bevel of theneedle 260 is sealed within thesecondary needle seal 3271 in the sheathed state of the injector system. In some embodiments, at least a majority of the bevel of theneedle 260 is sealed within thesecondary needle seal 3271 in the sheathed state of the injector system. In some embodiments, at least the bevel of theneedle 260 is sealed within thesecondary needle seal 3271 in the sheathed state of the injector system. In some embodiments, thesecondary needle seal 3271 seals an (e.g., one or more) implant(s) within thelumen needle 260 in the sheathed state of the injector system. In some embodiments, at least a portion of the implants are ejected from the in the sheathed state of the injector systemsecondary needle seal 3271 in the unsheathed state of the injector system. - Per
FIG. 32A , thesecondary needle seal 3271 comprises adistal portion 3271A, aproximal portion 3271C, and amesial portion 3271B between thedistal portion 3271A and theproximal portion 3271C. As shown, in some embodiments, thesecondary needle seal 3271 is axisymmetric. In some embodiments, an outer surface of thedistal portion 3271A is generally convex. In some embodiments, an outer surface of themesial portion 3271B is generally in the form of a conical frustum. In some embodiments, the outer surface of theproximal portion 3271C is generally cylindrical. In some embodiments, a bottom surface of thesecondary needle seal 3271 on theproximal portion 3271A comprises adivot 3271D. As shown, in some embodiments, thedivot 3271D is conical. Alternatively, in some embodiments, thedivot 3271D is cylindrical, a conical frustum, or any other prism. In some embodiments, an axis of symmetry (shown as vertical) of thedivot 3271D is generally coaxial with the axis of symmetry of thesecondary needle seal 3271. In some embodiments, an axis of symmetry of thedivot 3271D is generally coaxial with the axis of symmetry of theneedle 260. In some embodiments, thedivot 3271D is configured to accept and/or align theneedle 260. In some embodiments, thedivot 3271D is configured to direct theneedle 260 away from compressed areas of thesecondary needle seal 3271. In some embodiments, one or more edges of thesecondary needle seal 3271 are rounded. - In some embodiments, the boundary between the
distal portion 3271A and a first end of themesial portion 3271B forms adistal seal lip 3271E that extends perpendicular to the axis of symmetry of thesecondary needle seal 3271. In some embodiments, the boundary between theproximal portion 3271A and a second end of themesial portion 3271B, opposite the first end, forms aproximal seal lip 3271F that extends perpendicular to the axis of symmetry of thesecondary needle seal 3271. - In some embodiments, the minimum outer diameter of the
mesial portion 3271B is less than a maximum outer diameter of thedistal portion 3271A. In some embodiments, the maximum outer diameter of themesial portion 3271B is less than a maximum outer diameter of thedistal portion 3271A. In some embodiments, the minimum outer diameter of themesial portion 3271B is less than a maximum outer diameter of theproximal portion 3271C. In some embodiments, the maximum outer diameter of themesial portion 3271B is less than a maximum outer diameter of theproximal portion 3271C. - In some embodiments, per
FIGS. 33A and 33B , the exemplarysecondary needle sheath 3270 is configured to accept thesecondary needle seal 3271. In some embodiments, perFIGS. 33A and 33B , the exemplarysecondary needle sheath 3270 is configured to accept thesecondary needle seal 3271 such that agap 3201 exists between the exemplarysecondary needle sheath 3270 and the mesial portion 3721A of thesecondary needle seal 3271. In some embodiments, perFIG. 33B , thegap 3201 allows thesecondary needle seal 3271 to expand when theneedle 260 is inserted therethrough. In some embodiments, perFIG. 33B , thegap 3201 enables thesecondary needle sheath 3270 to securely retain thesecondary needle seal 3271 with minimal radial compression. In some embodiments, reduced radial compression prevents coring of thesecondary needle seal 3271. In some embodiments, thegap 3201 enables air to permeate out of thesecondary needle sheath 3270 and around at least a portion of thesecondary needle seal 3271. In some embodiments, thegap 3201 allows thesecondary needle seal 3271 to expand when theneedle 260 is inserted therethrough, to prevent coring of thesecondary needle seal 3271. In some embodiments, a distal surface of thesecondary needle sheath 3270 is flattened to form a distal sheath seal lip 3270F that mates with thedistal seal lip 3271E of thesecondary needle seal 3271. In some embodiments, thesecondary needle sheath 3270 comprises a proximal sheath seal lip 3270F, that mates with theproximal seal lip 3271F of the of thesecondary needle seal 3271. In some embodiments, the distal sheath seal lip 3270E and theproximal seal lip 3271F at least partially constrain translational and/or rotational movement of thesecondary needle seal 3271 with in thesecondary needle sheath 3270. - As shown in
FIGS. 4-6 , thefirst injector system 100 further comprises acollar 240, apush pin housing 230, and acollar sleeve 220. Further, as shown thecollar sleeve 220 couples to theneedle housing 250. As shown some embodiments, thecollar sleeve 220 couples to theneedle housing 250 by a snap. Alternatively, in some embodiments, thecollar sleeve 220 couples to theneedle housing 250 via a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof. Further, as shown thepush pin housing 230 couples to theneedle housing 250 by a snap, a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof. As shown a distal outer diameter of thepush pin housing 230 is less than an inner diameter of the second cavity of theneedle housing 250. Also as shown, thepush pin housing 230 comprises a chamfered thru-hole receiving a portion of the head of thepush pin 290 to maintain alignment of thepush pin 290 as it travels distally and proximally. Further, the chamfered thru-hole receives a portion of the distal end of theplunger 130, wherein the chamfer maintains alignment of the distal end of theplunger 130 against the head of thepush pin 290. In some embodiments, theplunger 130 comprises a first plunger outer diameter and a second plunger outer diameter distal to the first plunger outer diameter, wherein the second plunger outer diameter is smaller than the first plunger outer diameter. In some embodiments, the first plunger outer diameter is larger than the inner diameter of the chamfered thru-hole in thepush pin housing 230. In some embodiments, the second plunger outer diameter is smaller than the inner diameter of the chamfered thru-hole in thepush pin housing 230. - As shown, the
collar 240 couples to thecollar sleeve 220. In some embodiments, thecollar 240, when coupled to thecollar sleeve 220, prevents theneedle sheath 270 from translating in a distal direction, a proximal direction or both. In some embodiments, thecollar 240, when decoupled from thecollar sleeve 220, allows theneedle sheath 270 to translate in a distal direction, a proximal direction or both. In some embodiments, theneedle assembly 210 is in a sheathed state, perFIG. 4 , when thecollar 240 is coupled to thecollar sleeve 220. In some embodiments, theneedle assembly 210 is in an unsheathed state, perFIG. 5 , when thecollar 240 is decoupled from thecollar sleeve 220. In some embodiments, thecollar 240 couples to thecollar sleeve 220 by rotating thecollar 240, translating thecollar 240, or both with respect to thecollar sleeve 220. In some embodiments, thecollar 240 decouples from thecollar sleeve 220 by rotating thecollar 240, translating thecollar 240, or both with respect to thecollar sleeve 220. Further, as shown, thecollar 240 comprises a tab to enable rotation of thecollar 240, translation of thecollar 240, or both with respect to thecollar sleeve 220. - As shown in
FIGS. 4-6 , at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction ejects the (e.g., one or more) implant(s) 300 positioned inside the needle lumen out of the needle lumen and into the eye of the patient. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction partially ejects the (e.g., one or more) implant(s) 300 out of the needle lumen. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. - In some embodiments, at least one of the
push pin 290, theneedle housing 250, and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 distal to the distal end of theneedle 260. In some embodiments, at least one of thepush pin 290, theneedle housing 250, and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 distal to the distal end of theneedle 260 by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of thepush pin 290, theneedle housing 250, and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 distal to the distal end of theneedle 260 by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of thepush pin 290, theneedle housing 250, and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 distal to the distal end of theneedle 260 by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 proximal to the distal end of theneedle 260. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 proximal to the distal end of theneedle 260 by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 proximal to the distal end of theneedle 260 by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, at least one of thepush pin 290, theneedle housing 250 and theneedle 260 is dimensioned such that translating thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 proximal to the distal end of theneedle 260 by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. - In some embodiments, at least one of the
push pin 290, theneedle housing 250, or theneedle 260 is dimensioned such that applying an actuating force on thepush pin 290 in a distal direction positions a distal end of the push rod of thepush pin 290 distal to the distal end of theneedle 260. In some embodiments, thepush pin 290 retracts within theneedle 260 after the actuating force is removed. In some embodiments, thepush pin 290 retracts within theneedle 260 by a distance of at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, thepush pin 290 retracts within theneedle 260 by a distance of at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, thepush pin 290 retracts within theneedle 260 by a distance of 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm from the distal face of theneedle 260 after the actuating force is removed. - In some embodiments, the
needle 260 has a length such that the distal end of theneedle 260 is within the needle seal when theneedle assembly 210 is in a sheathed state. Further, as shown, at least a portion of the push rod of thepush pin 290 is disposed within theneedle 260, and at least a portion of thepush pin 290 is disposed within theneedle housing 250. As shown a distal portion of thepush pin 290 is disposed within theneedle 260, and a proximal portion of thepush pin 290 is disposed within theneedle housing 250. Further, as shown, at a proximal portion of thepush pin 290 is disposed within the second cavity of theneedle housing 250, an intermediate portion of thepush pin 290 is disposed within the first cavity of theneedle housing 250, and thepush pin 290 passes through the thru-hole of theneedle housing 250. As shown, a distal end of theneedle 260 extends beyond the distal end of theneedle housing 250. In some embodiments, a distal end of theneedle 260 extends beyond the distal end of theneedle housing 250 by about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm or more. In some embodiments, a distal end of theneedle 260 extends beyond the distal end of theneedle housing 250 by at least about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. In some embodiments, a distal end of theneedle 260 extends beyond the distal end of theneedle housing 250 by at most about 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10 mm. - As shown, the push rod of the
push pin 290 translates within the needle lumen. Further as shown, the push rod has an outer diameter of less than the inner diameter of theneedle 260. Alternatively, in some embodiments, the head has an outer diameter greater than the inner diameter of theneedle 260. In some embodiments, the head does not fit within theneedle 260. In some embodiments, at least a portion of the head does not fit within theneedle 260. In some embodiments, thepush pin 290 is dimensioned and positioned in the needle lumen such that distal translating of thepush pin 290 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen. In some embodiments, thepush pin 290 is dimensioned and positioned in the needle lumen such that distal translating of thepush pin 290 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen. In some embodiments, thepush pin 290 is dimensioned and positioned in the needle lumen such that distal translating of thepush pin 290 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen into the eye of the patient. In some embodiments, a distal surface of the push rod of thepush pin 290 contacts the distal portion of the (e.g., one or more) implant(s) 300 in the extended position, the retracted position, or both of the plunger assembly 200. - In some embodiments, the (e.g., one or more) implant(s) 300 has a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) 300 comprise a plurality of particles. In some embodiments, the (e.g., one or more) implant(s) 300 have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon.
- In some embodiments, the
needle 260 has a length such that the distal end of theneedle 260 is within the needle seal when theneedle assembly 210 is in the sheathed state. In some embodiments, theneedle 260 has a length of about 5 mm to about 70 mm. In some embodiments, the needle 260 has a length of about 5 mm to about 10 mm, about 5 mm to about 15 mm, about 5 mm to about 20 mm, about 5 mm to about 25 mm, about 5 mm to about 30 mm, about 5 mm to about 35 mm, about 5 mm to about 40 mm, about 5 mm to about 45 mm, about 5 mm to about 50 mm, about 5 mm to about 60 mm, about 5 mm to about 70 mm, about 10 mm to about 15 mm, about 10 mm to about 20 mm, about 10 mm to about 25 mm, about 10 mm to about 30 mm, about 10 mm to about 35 mm, about 10 mm to about 40 mm, about 10 mm to about 45 mm, about 10 mm to about 50 mm, about 10 mm to about 60 mm, about 10 mm to about 70 mm, about 15 mm to about 20 mm, about 15 mm to about 25 mm, about 15 mm to about 30 mm, about 15 mm to about 35 mm, about 15 mm to about 40 mm, about 15 mm to about 45 mm, about 15 mm to about 50 mm, about 15 mm to about 60 mm, about 15 mm to about 70 mm, about 20 mm to about 25 mm, about 20 mm to about 30 mm, about 20 mm to about 35 mm, about 20 mm to about 40 mm, about 20 mm to about 45 mm, about 20 mm to about 50 mm, about 20 mm to about 60 mm, about 20 mm to about 70 mm, about 25 mm to about 30 mm, about 25 mm to about 35 mm, about 25 mm to about 40 mm, about 25 mm to about 45 mm, about 25 mm to about 50 mm, about 25 mm to about 60 mm, about 25 mm to about 70 mm, about 30 mm to about 35 mm, about 30 mm to about 40 mm, about 30 mm to about 45 mm, about 30 mm to about 50 mm, about 30 mm to about 60 mm, about 30 mm to about 70 mm, about 35 mm to about 40 mm, about 35 mm to about 45 mm, about 35 mm to about 50 mm, about 35 mm to about 60 mm, about 35 mm to about 70 mm, about 40 mm to about 45 mm, about 40 mm to about 50 mm, about 40 mm to about 60 mm, about 40 mm to about 70 mm, about 45 mm to about 50 mm, about 45 mm to about 60 mm, about 45 mm to about 70 mm, about 50 mm to about 60 mm, about 50 mm to about 70 mm, or about 60 mm to about 70 mm. In some embodiments, theneedle 260 has a length of about 5 mm, about 10 mm, about 15 mm, about 20 mm, about 25 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm. In some embodiments, theneedle 260 has a length of at least about 5 mm, about 10 mm, about 15 mm, about 20 mm, about 25 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, or about 60 mm. In some embodiments, theneedle 260 has a length of at most about 10 mm, about 15 mm, about 20 mm, about 25 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm. In some embodiments, the length of theneedle 260 is a maximum length, a minimum length, a normal length, or an average length. - As shown in
FIGS. 4, 5, and 7 theinjector system 100 comprises aplunger housing 120, aplunger 130, and acompression spring 140. As shown, theplunger 130 is slidably disposed within theplunger housing 120. Further, as shown, a distal end of theplunger 130 is adapted to engage and push thepush pin 290 of theneedle assembly 210 when in a distal position within theplunger housing 120. - In some embodiments, the distal end of the
plunger 130 engages the head of thepush pin 290 of theneedle assembly 210. In some embodiments, theplunger 130 is manually actuated to translate distally within theplunger housing 120. In some embodiments, theplunger housing 120 is a syringe barrel. In some embodiments, the syringe barrel is a 1 mL syringe barrel. In some embodiments, a proximal end of thesyringe plunger 130 protrudes beyond theplunger housing 120. In some embodiments, theplunger 130 is mechanically actuated to translate distally within theplunger housing 120. In some embodiments, theplunger assembly 110 further comprises acompression spring 140 biasing theplunger 130 towards a proximal end of theplunger housing 120. In some embodiments, thecompression spring 140 has a distal end connected to theplunger housing 120 and a proximal end connected to theplunger 130. In some embodiments, perFIG. 19 , theplunger housing 120 is a biopsy punch. - In some embodiments, the
plunger 130 comprises afirst stop feature 131, wherein theplunger housing 120 comprises asecond stop 121 122 123 feature engageable with thefirst stop feature 131. In some embodiments, the second stop feature comprises a primarysecond stop 121 and a secondary second stop 122. In some embodiments, the second stop feature comprises a primarysecond stop 121, a secondary second stop 122, and a tertiarysecond stop 123. In some embodiments, the second stop feature does not comprise the tertiarysecond stop 123. In some embodiments, thefirst stop feature 131 engages with the primarysecond stop 121 in the retracted position of theplunger assembly 110. In some embodiments, thefirst stop feature 131 engages with the secondary second stop 122 in the extended position of theplunger assembly 110. In some embodiments, thefirst stop feature 131 engages with the secondary second stop 122 in a first extended position of theplunger assembly 110. In some embodiments, thefirst stop feature 131 engages with thetertiary stop 123 in a second extended position of theplunger assembly 110. In some embodiments, perFIG. 34B , theinjector system 100 ejects afirst implant 300 in the first extended position, and ejects asecond implant 300 in the second extended position. In some embodiments, thefirst stop feature 131 engages with the secondary second stop 122 only in the unsheathed state of theneedle assembly 210. In some embodiments, thefirst stop feature 131 engages with the secondary second stop 122 in the extended position or the first extended position of theplunger assembly 110, wherein upon implantation, distal force on the plunger advances thefirst stop feature 131 past the secondary second stop 122 by a retraction distance, whereafter reduction or release of the distal force returns thefirst stop feature 131 proximally by the retraction distance to engage with the secondary second stop 122. In some embodiments, thefirst stop feature 131 engages with the tertiarysecond stop 123 in the second extended position of theplunger assembly 110, wherein upon implantation, distal force on the plunger advances thefirst stop feature 131 past the tertiarysecond stop 123 by a retraction distance, whereafter reduction or release of the distal force returns thefirst stop feature 131 proximally by the retraction distance to engage with the tertiarysecond stop 123. As shown, thefirst stop feature 131 comprises a flexure, wherein the primarysecond stop 121 and the secondary second stop 122 comprise a slot. Alternatively, thefirst stop feature 131 comprises a snap, a detent, a spring, a clip, or any combination thereof. Alternatively, at least one of the primarysecond stop 121 and the secondary second stop 122 comprise a snap, a detent, a spring, a clip, or any combination thereof. Further as shown, the secondary second stop 122 is distal to the primarysecond stop 121. In some embodiments, a distance between the primarysecond stop 121 and the secondary second stop 122 determines the distance that theplunger 130 translates from the extended position to the retracted position. In some embodiments, a distance between the primarysecond stop 121 and the secondary second stop 122 determines the distance that thepush pin 290 translates. In some embodiments, a distance between the primarysecond stop 121 and the secondary second stop 122 determines the distance that the (e.g., one or more) implant(s) 300 translate. In some embodiments, a distance between the primarysecond stop 121 and the secondary second stop 122 minus the length of the (e.g., one or more) implant(s) 300 determines the distance that the (e.g., one or more) implant(s) 300 are deposited into the eye of a subject. - As shown in
FIGS. 4 and 5 , theplunger 130 comprises a first plunger outer diameter and a second plunger outer diameter distal to the first plunger outer diameter, wherein the second plunger outer diameter is smaller than the first plunger outer diameter. In some embodiments, the first plunger outer diameter is larger than the inner diameter of the chamfered thru-hole in thepush pin housing 230. In some embodiments, the second plunger outer diameter is smaller than the inner diameter of the chamfered thru-hole in thepush pin housing 230. - Provided herein per
FIGS. 8-15 is asecond injector system 800 for injecting an (e.g., one or more) implant(s) 300 into an eye of a patient, the system comprising aneedle assembly 910 and aplunger assembly 810. As shown, theneedle assembly 910 removably couples to a distal end of theplunger assembly 810. In some embodiments, theneedle assembly 910 removably couples to a distal end of theplunger assembly 810 by a snap, a screw, a pin, a band, a clamp, or any combination thereof. Alternatively, in some embodiments, theneedle assembly 910 permanently couples to theplunger assembly 810. In some embodiments, theneedle assembly 910 is maneuverable between a sheathed state and an unsheathed state.FIG. 8 shows a sheathed state of theneedle assembly 910, andFIG. 2 shows an unsheathed state of theneedle assembly 910. In some embodiments, theplunger assembly 810 is maneuverable between an extended position and a retracted position. - As seen per
FIGS. 10, 11, 14, and 15 theexemplary needle assembly 910 comprises aneedle housing 950, aneedle 260, and apush pin 990. In some embodiments, theneedle assembly 910 further comprises the (e.g., one or more) implant(s) 300 loaded in theneedle 260. In some embodiments, theneedle assembly 910 further comprises the (e.g., one or more) implant(s) 300 loaded in a lumen of theneedle 260. In some embodiments, perFIG. 34A , the (e.g., one or more) implant(s) 300 comprise afirst implant 300A and asecond implant 300B, wherein thefirst implant 300A and thesecond implant 300B are loaded in parallel into theneedle 260. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such that their longitudinal axes of symmetry are within about 10 degrees of parallel. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such that their longitudinal axes of symmetry at least partially overlap. In some embodiments, perFIG. 34B , thefirst implant 300A and thesecond implant 300B are sequentially loaded in series into theneedle 260. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such that their longitudinal axes of symmetry are within about 10 degrees of being coaxial. In some embodiments, thefirst implant 300A and thesecond implant 300B are held within theneedle 260 such a proximal point of thefirst implant 300A contacts a distal point of thesecond implant 300B. In some embodiments, thefirst implant 300A and thesecond implant 300B are ejected from theneedle 260 simultaneously. In some embodiments, thefirst implant 300A and thesecond implant 300B are ejected from theneedle 260 in series. In some embodiments, thefirst implant 300A and thesecond implant 300B are embedded in a solid or liquid media that maintains a set distance between one or more of their surfaces. - As shown, the
needle housing 950 has a proximal end and a distal end. Further, as shown, theneedle housing 950 comprises a male luer taper, a thru-hole, a first cavity, and a second cavity. Alternatively, in some embodiments, theneedle housing 950 does not comprise one or more of the male luer taper, the thru-hole, the first cavity, and the second cavity. In some embodiments, two or more of the male luer taper, the thru-hole, the first cavity, and the second cavity are concentric. As shown, a distal termination of the first cavity is distal to the distal termination of the male luer taper. As shown, a proximal termination of the first cavity is distal to the distal termination of the male luer taper. - As shown, the
needle 260 comprises a needle lumen at the distal end of theneedle 260 and a female luer taper at the proximal end of theneedle 260. In some embodiments, theneedle 260 has a gauge of 90 to 40. In some embodiments, theneedle 260 has a gauge of 90 to 92, 90 to 94, 90 to 96, 90 to 98, 90 to 30, 90 to 32, 90 to 34, 90 to 36, 90 to 38, 90 to 40, 92 to 94, 92 to 96, 92 to 98, 92 to 30, 92 to 32, 92 to 34, 92 to 36, 92 to 38, 92 to 40, 94 to 96, 94 to 98, 94 to 30, 94 to 32, 94 to 34, 94 to 36, 94 to 38, 94 to 40, 96 to 98, 96 to 30, 96 to 32, 96 to 34, 96 to 36, 96 to 38, 96 to 40, 98 to 30, 98 to 32, 98 to 34, 98 to 36, 98 to 38, 98 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40. In some embodiments, theneedle 260 has a gauge of 90, 92, 94, 96, 98, 30, 32, 34, 36, 38or 40. In some embodiments, theneedle 260 has a gauge of at least 90, 92, 94, 96, 98, 30, 32, 34, 36, or 38. In some embodiments, theneedle 260 has a gauge of at most 92, 94, 96, 98, 30, 32, 34, 36, 38, or 40. In some embodiments, theneedle 260 has a gauge of 93 to 30. In some embodiments, theneedle 260 has a gauge of 93. In some embodiments, theneedle 260 has a gauge of 30. In some embodiments, theneedle 260 is straight. In some embodiments, theneedle 260 is curved. In some embodiments, thecurved needle 260 has a curvature radius of about 80, 90, 30, 40, 50, 60, 70, 80, 90 mm or more. In some embodiments, theneedle 260 is twisted. In some embodiments, thetwisted needle 260 has a pitch of about 5, 80, 85, 90, 95, 30, 35, 40, 45, 50 mm or more. In some embodiments, thetwisted needle 260 has a maximum outer diameter of about 5, 80, 85, 90, 95, 30, 35, 40, 45, 50 mm or more. In some embodiments, theneedle 260 is a commercially available needle. - As shown in
FIGS. 10, 11, 14, and 15 theexemplary push pin 990 has a head and a push rod. Further, as shown, the head is positioned proximally to the push rod. As shown a proximal end of theneedle 260 is coupled to the distal end of theneedle housing 950 and thepush pin 990 is disposed within theneedle housing 950. Alternatively, in some embodiments, a proximal end of theneedle 260 is within theneedle housing 950. As shown, the push rod of thepush pin 990 has an outer diameter of less than the inner diameter of the thru-hole of theneedle housing 950. - As shown in
FIGS. 10, 11, 14, and 15 , theneedle assembly 910 further comprises aresilient member 980 disposed within theneedle housing 950. In some embodiments, theresilient member 980 proximally biases thepush pin 990. In some embodiments, theresilient member 980 proximally biases thepush pin 990 when theneedle assembly 910 is in a sheathed state. In some embodiments, theresilient member 980 proximally biases thepush pin 990 when theneedle assembly 910 is in an unsheathed state. As shown, theresilient member 980 is a spring. Alternatively, in some embodiments, theresilient member 980 is a flexure, a piston, a motor, a band, or any combination thereof. In some embodiments, theresilient member 980 is disposed within and constrained by the first cavity of theneedle housing 950. In some embodiments, theresilient member 980 has an outer diameter of less than an inner diameter of the first cavity of theneedle housing 950. As shown, the push rod of thepush pin 990 has an outer diameter of less than an inner diameter of theresilient member 980. - As shown in
FIGS. 10, 11, 14, and 15 , theneedle assembly 910 further comprises aneedle sheath 970 surrounding at least a portion of theneedle housing 950, and having a distal portion surrounding the distal end of theneedle 260. In some embodiments, a proximal portion of theneedle sheath 970 surrounds the distal end of theneedle housing 950. In some embodiments, a distal face of theneedle sheath 970 is more distal to theneedle housing 950 in the sheathed state of theneedle assembly 910 than in the unsheathed state of theneedle assembly 910. In some embodiments, a distal face of theneedle sheath 970 is more distal to theplunger housing 120 in the sheathed state of theneedle assembly 910 than in the unsheathed state of theneedle assembly 910. - In some embodiments, when the
needle assembly 910 is the sheathed, theneedle 260 is entirely surrounded by theneedle sheath 970. In some embodiments, when theneedle assembly 910 is in the unsheathed state, at least a portion of theneedle 260 extends distally beyond theneedle sheath 970. In some embodiments, the distal portion of theneedle sheath 970 abuts the eye of the patient when the (e.g., one or more) implant(s) 300 are ejected from the needle lumen. In some embodiments, the distal portion of theneedle sheath 970 abuts the eye of the patient when theneedle assembly 910 is in its sheathed state. In some embodiments, the distal portion of theneedle sheath 970 abuts the eye of the patient when theneedle assembly 910 is in its unsheathed state. In some embodiments, the distal portion of theneedle sheath 970 abuts the eye of the patient when the needle lumen is within the eye of the patient. In some embodiments, the distal portion of theneedle sheath 970 abuts the eye of the patient when the needle lumen is within theneedle sheath 970. In some embodiments, theneedle sheath 970 is removable from theneedle housing 950. In some embodiments, theneedle sheath 970 is removable from theneedle housing 950 by translation of theneedle sheath 970 in a distal direction with respect to theneedle housing 950. In some embodiments, theneedle sheath 970 is removable from theneedle housing 950 by translation of theneedle sheath 970 in a proximal direction with respect to theneedle housing 950. - As shown in
FIGS. 10, 11, 14, and 15 , thesecond injector system 800 further comprises aneedle seal 971 at the distal end of theneedle 260 that seals the distal end of the needle lumen. In some embodiments, theneedle seal 971 is within a distal portion of theneedle sheath 970. In some embodiments, theneedle seal 971 is molded within a distal portion of theneedle sheath 970. In some embodiments, theneedle seal 971 is adhered or coupled to a distal portion of theneedle sheath 970. In some embodiments, theneedle seal 971 is formed of a polymer. In some embodiments, the polymer is rubber, plastic, or both. In some embodiments, theneedle seal 971 is removable. In some embodiments, translating theneedle sheath 970 in a proximal direction causes theneedle 260 to pierce theneedle seal 971. -
FIGS. 32A-32B show an exemplarysecondary needle seal 3271 and an exemplarysecondary needle sheath 3270. PerFIG. 32A , thesecondary needle seal 3271 comprises adistal portion 3271A, aproximal portion 3271C, and amesial portion 3271B between thedistal portion 3271A and theproximal portion 3271C. As shown, in some embodiments, thesecondary needle seal 3271 is axisymmetric. In some embodiments, an outer surface of thedistal portion 3271A is generally convex. In some embodiments, an outer surface of themesial portion 3271B is generally in the form of a conical frustum. In some embodiments, the outer surface of theproximal portion 3271C is generally cylindrical. In some embodiments, a bottom surface of thesecondary needle seal 3271 on theproximal portion 3271A comprises adivot 3271D. As shown, in some embodiments, thedivot 3271D is conical. Alternatively, in some embodiments, thedivot 3271D is cylindrical, a conical frustum, or any other prism. In some embodiments, an axis of symmetry (shown as vertical) of thedivot 3271D is generally coaxial with the axis of symmetry of thesecondary needle seal 3271. In some embodiments, an axis of symmetry of thedivot 3271D is generally coaxial with the axis of symmetry of theneedle 260. In some embodiments, thedivot 3271D is configured to accept and/or align theneedle 260. In some embodiments, thedivot 3271D is configured to direct theneedle 260 away from compressed areas of thesecondary needle seal 3271. In some embodiments, one or more edges of thesecondary needle seal 3271 are rounded. - In some embodiments, the boundary between the
distal portion 3271A and a first end of themesial portion 3271B forms adistal seal lip 3271E that extends perpendicular to the axis of symmetry of thesecondary needle seal 3271. In some embodiments, the boundary between theproximal portion 3271A and a second end of themesial portion 3271B, opposite the first end, forms aproximal seal lip 3271F that extends perpendicular to the axis of symmetry of thesecondary needle seal 3271. - In some embodiments, the minimum outer diameter of the
mesial portion 3271B is less than a maximum outer diameter of thedistal portion 3271A. In some embodiments, the maximum outer diameter of themesial portion 3271B is less than a maximum outer diameter of thedistal portion 3271A. In some embodiments, the minimum outer diameter of themesial portion 3271B is less than a maximum outer diameter of theproximal portion 3271C. In some embodiments, the maximum outer diameter of themesial portion 3271B is less than a maximum outer diameter of theproximal portion 3271C. - In some embodiments, per
FIGS. 33A and 33B , the exemplarysecondary needle sheath 3270 is configured to accept thesecondary needle seal 3271. In some embodiments, perFIGS. 33A and 33B , the exemplarysecondary needle sheath 3270 is configured to accept thesecondary needle seal 3271 such that agap 3201 exists between the exemplarysecondary needle sheath 3270 and the mesial portion 3721A of thesecondary needle seal 3271. In some embodiments, perFIG. 33B , thegap 3201 allows thesecondary needle seal 3271 to expand when theneedle 260 is inserted therethrough. In some embodiments, perFIG. 33B , thegap 3201 enables thesecondary needle sheath 3270 to securely retain thesecondary needle seal 3271 with minimal radial compression. In some embodiments, reduced radial compression prevents coring of thesecondary needle seal 3271. In some embodiments, thegap 3201 enables air to permeate out of thesecondary needle sheath 3270 and around at least a portion of thesecondary needle seal 3271. In some embodiments, thegap 3201 allows thesecondary needle seal 3271 to expand when theneedle 260 is inserted therethrough, to prevent coring of thesecondary needle seal 3271. In some embodiments, a distal surface of thesecondary needle sheath 3270 is flattened to form a distal sheath seal lip 3270F that mates with thedistal seal lip 3271E of thesecondary needle seal 3271. In some embodiments, thesecondary needle sheath 3270 comprises a proximal sheath seal lip 3270F, that mates with theproximal seal lip 3271F of the of thesecondary needle seal 3271. In some embodiments, the distal sheath seal lip 3270E and theproximal seal lip 3271F at least partially constrain translational and/or rotational movement of thesecondary needle seal 3271 with in thesecondary needle sheath 3270. - As shown in
FIGS. 10, 11, 14, and 15 , thesecond injector system 800 further comprises acollar 940, aplunger attachment sleeve 930, and acollar sleeve 920. Further, as shown thecollar sleeve 920 couples to at least one of theneedle housing 950, theplunger attachment sleeve 930, or theneedle sheath 970. As shown some embodiments, thecollar sleeve 920 couples to theneedle sheath 970 by a snap. Alternatively, in some embodiments, thecollar sleeve 920 couples to theneedle sheath 970 via a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof. Further, as shown theplunger attachment sleeve 930 couples to the needle housing, thecollar sleeve 920, or both by a snap. Alternatively, theplunger attachment sleeve 930 couples to the needle housing, thecollar sleeve 920, or both by a clip, a magnet, a screw, a bolt, a nut, an adhesive, or any combination thereof. As shown a distal outer diameter of theplunger attachment sleeve 930 is greater than an inner diameter of the second cavity of theneedle housing 950. Also as shown, theplunger attachment sleeve 930 removably connects to theplunger housing 820. - As shown, the
collar 940 couples to thecollar sleeve 920. In some embodiments, thecollar 940, when coupled to thecollar sleeve 920, prevents theneedle sheath 970 from translating in a distal direction, a proximal direction or both. In some embodiments, thecollar 940, when decoupled from thecollar sleeve 920, allows theneedle sheath 970 to translate in a distal direction, a proximal direction or both. In some embodiments, theneedle assembly 910 is in a sheathed state, perFIG. 10 , when thecollar 940 is coupled to thecollar sleeve 920. In some embodiments, theneedle assembly 910 is in an unsheathed state, perFIG. 11 , when thecollar 940 is decoupled from thecollar sleeve 920. In some embodiments, thecollar 940 couples to thecollar sleeve 920 by rotating thecollar 940, translating thecollar 940, or both with respect to thecollar sleeve 920. In some embodiments, thecollar 940 decouples from thecollar sleeve 920 by rotating thecollar 940, translating thecollar 940, or both with respect to thecollar sleeve 920. - As shown in
FIGS. 10, 11, 14, and 15 , at least one of thepush pin 990, theneedle housing 950 and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction ejects the (e.g., one or more) implant(s) 300 positioned inside the needle lumen out of the needle lumen and into the eye of the patient. In some embodiments, at least one of thepush pin 990, theneedle housing 950 and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction partially ejects the (e.g., one or more) implant(s) 300 out of the needle lumen. In some embodiments, at least one of thepush pin 990, theneedle housing 950 and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen. In some embodiments, at least one of thepush pin 990, theneedle housing 950 and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction completely ejects the (e.g., one or more) implant(s) 300 out of the needle lumen by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more. - In some embodiments, at least one of the
push pin 990, theneedle housing 950, and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction positions a distal end of the push rod of thepush pin 990 distal to the distal end of theneedle 260. In some embodiments, at least one of thepush pin 990, theneedle housing 950, and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction positions a distal end of the push rod of thepush pin 990 distal to the distal end of theneedle 260 by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more. In some embodiments, at least one of thepush pin 990, theneedle housing 950 and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction positions a distal end of the push rod of thepush pin 990 proximal to the distal end of theneedle 260. In some embodiments, at least one of thepush pin 990, theneedle housing 950 and theneedle 260 is dimensioned such that translating thepush pin 990 in a distal direction positions a distal end of the push rod of thepush pin 990 proximal to the distal end of theneedle 260 by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more. - In some embodiments, the
needle 260 has a length such that the distal end of theneedle 260 is within the needle seal when theneedle assembly 910 is in a sheathed state. Further, as shown, at least a portion of the push rod of thepush pin 990 is disposed within theneedle 260, and at least a portion of thepush pin 990 is disposed within theneedle housing 950. As shown a distal portion of thepush pin 990 is disposed within theneedle 260, and a proximal portion of thepush pin 990 is disposed within theneedle housing 950. Further, as shown, a proximal portion of thepush pin 990 is disposed within the second cavity of theneedle housing 950, an intermediate portion of thepush pin 990 is disposed within the first cavity of theneedle housing 950, and thepush pin 990 passes through the thru-hole of theneedle housing 950. As shown, a distal end of theneedle 260 extends beyond the distal end of theneedle housing 950. In some embodiments, a distal end of theneedle 260 extends beyond the distal end of theneedle housing 950 by 8, 9, 3, 4, 5, 6, 7, 8, 9, 80 mm or more. - As shown, the push rod of the
push pin 990 translates within the needle lumen. Further as shown, the push rod has an outer diameter of less than the inner diameter of theneedle 260. Alternatively, in some embodiments, the head has an outer diameter greater than the inner diameter of theneedle 260. In some embodiments, the head does not fit within theneedle 260. In some embodiments, thepush pin 990 is dimensioned and positioned in the needle lumen such that distal translating of thepush pin 990 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen. In some embodiments, thepush pin 990 is dimensioned and positioned in the needle lumen such that distal translating of thepush pin 990 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen. In some embodiments, thepush pin 990 is dimensioned and positioned in the needle lumen such that distal translating of thepush pin 990 pushes the (e.g., one or more) implant(s) 300 positioned inside the needle lumen to out of the needle lumen into the eye of the patient. In some embodiments, a distal surface of the push rod of thepush pin 990 contacts the distal portion of the (e.g., one or more) implant(s) 300 during the sheathed state, the unsheathed state, or both of theneedle assembly 910. In some embodiments, a distal surface of the push rod of thepush pin 990 contacts the distal portion of the (e.g., one or more) implant(s) 300 during a sheathed state of the device, an unsheathed state of the device, or both of theneedle assembly 910. - In some embodiments, the (e.g., one or more) implant(s) 300 have a shape of elongated cylinder. In some embodiments, the (e.g., one or more) implant(s) 300 comprise a plurality of particles. In some embodiments, the (e.g., one or more) implant(s) 300 have a cross sectional shape of a circle, a triangle, a square, a rectangle, or any other polygon.
- In some embodiments, the
needle 260 has a length such that the distal end of theneedle 260 is within the needle seal when theneedle assembly 910 is in a sheathed state. In some embodiments, theneedle 260 has a length of about 5 mm to about 70 mm. In some embodiments, the needle 260 has a length of about 5 mm to about 80 mm, about 5 mm to about 85 mm, about 5 mm to about 90 mm, about 5 mm to about 95 mm, about 5 mm to about 30 mm, about 5 mm to about 35 mm, about 5 mm to about 40 mm, about 5 mm to about 45 mm, about 5 mm to about 50 mm, about 5 mm to about 60 mm, about 5 mm to about 70 mm, about 80 mm to about 85 mm, about 80 mm to about 90 mm, about 80 mm to about 95 mm, about 80 mm to about 30 mm, about 80 mm to about 35 mm, about 80 mm to about 40 mm, about 80 mm to about 45 mm, about 80 mm to about 50 mm, about 80 mm to about 60 mm, about 80 mm to about 70 mm, about 85 mm to about 90 mm, about 85 mm to about 95 mm, about 85 mm to about 30 mm, about 85 mm to about 35 mm, about 85 mm to about 40 mm, about 85 mm to about 45 mm, about 85 mm to about 50 mm, about 85 mm to about 60 mm, about 85 mm to about 70 mm, about 90 mm to about 95 mm, about 90 mm to about 30 mm, about 90 mm to about 35 mm, about 90 mm to about 40 mm, about 90 mm to about 45 mm, about 90 mm to about 50 mm, about 90 mm to about 60 mm, about 90 mm to about 70 mm, about 95 mm to about 30 mm, about 95 mm to about 35 mm, about 95 mm to about 40 mm, about 95 mm to about 45 mm, about 95 mm to about 50 mm, about 95 mm to about 60 mm, about 95 mm to about 70 mm, about 30 mm to about 35 mm, about 30 mm to about 40 mm, about 30 mm to about 45 mm, about 30 mm to about 50 mm, about 30 mm to about 60 mm, about 30 mm to about 70 mm, about 35 mm to about 40 mm, about 35 mm to about 45 mm, about 35 mm to about 50 mm, about 35 mm to about 60 mm, about 35 mm to about 70 mm, about 40 mm to about 45 mm, about 40 mm to about 50 mm, about 40 mm to about 60 mm, about 40 mm to about 70 mm, about 45 mm to about 50 mm, about 45 mm to about 60 mm, about 45 mm to about 70 mm, about 50 mm to about 60 mm, about 50 mm to about 70 mm, or about 60 mm to about 70 mm. In some embodiments, theneedle 260 has a length of about 5 mm, about 80 mm, about 85 mm, about 90 mm, about 95 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm. In some embodiments, theneedle 260 has a length of at least about 5 mm, about 80 mm, about 85 mm, about 90 mm, about 95 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, or about 60 mm. In some embodiments, theneedle 260 has a length of at most about 80 mm, about 85 mm, about 90 mm, about 95 mm, about 30 mm, about 35 mm, about 40 mm, about 45 mm, about 50 mm, about 60 mm, or about 70 mm. In some embodiments, the length of theneedle 260 is a maximum length, a minimum length, a normal length, or an average length. - As shown in
FIGS. 10-13 thesecond injector system 800 comprises aplunger housing 820, aplunger 830, and acompression spring 840. As shown, theplunger 830 is slidably disposed within theplunger housing 820. Further, as shown, a distal end of theplunger 830 is adapted to engage and push thepush pin 990 of theneedle assembly 910 when in a distal position within theplunger housing 820. - In some embodiments, the distal end of the
plunger 830 engages the head of thepush pin 990 of theneedle assembly 910. In some embodiments, theplunger 830 is manually actuated to translate distally within theplunger housing 820. In some embodiments, theplunger housing 820 is a syringe barrel. In some embodiments, the syringe barrel is a 1 mL syringe barrel. In some embodiments, a proximal end of thesyringe plunger 830 protrudes beyond theplunger housing 820. In some embodiments, theplunger 830 is mechanically actuated to translate distally within theplunger housing 820. In some embodiments, theplunger assembly 810 further comprises acompression spring 840 biasing theplunger 830 towards a proximal end of theplunger housing 820. In some embodiments, thecompression spring 840 has a distal end connected to theplunger housing 820 and a proximal end connected to theplunger 830. - In some embodiments, the
plunger 830 comprises afirst stop feature 831, wherein theplunger housing 820 comprises asecond stop 821 822 823 feature engageable with thefirst stop feature 831. In some embodiments, the second stop feature comprises a primarysecond stop 821 and a secondarysecond stop 822. In some embodiments, the second stop feature comprises a primarysecond stop 821, a secondarysecond stop 822, and a tertiarysecond stop 823. In some embodiments, the second stop feature does not comprise the tertiarysecond stop 823. In some embodiments, the primarysecond stop 821 engages with thefirst stop feature 831 in the sheathed state of theneedle assembly 910. In some embodiments, the secondarysecond stop 822 engages with thefirst stop feature 831 in the unsheathed state of theneedle assembly 910. In some embodiments, thefirst stop feature 831 engages with the secondarysecond stop 822 in a first extended position of theplunger assembly 810. In some embodiments, thefirst stop feature 831 engages with thetertiary stop 823 in a second extended position of theplunger assembly 810. In some embodiments, perFIG. 34B , theinjector system 800 ejects afirst implant 300 in the first extended position, and ejects asecond implant 300 in the second extended position. In some embodiments, the primarysecond stop 821 engages with thefirst stop feature 831 in the sheathed state of theneedle assembly 910 or the first extended position, wherein upon implantation, distal force on the plunger advances thefirst stop feature 831 past the secondarysecond stop 822 by a retraction distance, whereafter reduction or release of the distal force returns thefirst stop feature 831 proximally by the retraction distance to engage with the secondarysecond stop 822. In some embodiments, thefirst stop feature 831 engages with the tertiarysecond stop 823 in the second extended position of theplunger assembly 810, wherein upon implantation, distal force on the plunger advances thefirst stop feature 831 past the tertiarysecond stop 823 by a retraction distance, whereafter reduction or release of the distal force returns thefirst stop feature 831 proximally by the retraction distance to engage with the tertiarysecond stop 823. As shown, thefirst stop feature 831 comprises a flexure, wherein the primarysecond stop 821 and the secondarysecond stop 822 comprise a slot. Alternatively, thefirst stop feature 831 comprises a snap, a detent, a spring, a clip, or any combination thereof. Alternatively, at least one of the primarysecond stop 821 and the secondarysecond stop 822 comprise a snap, a detent, a spring, a clip, or any combination thereof. Further as shown, the secondarysecond stop 822 is distal to the primarysecond stop 821. In some embodiments, a distance between the primarysecond stop 821 and the secondarysecond stop 822 determines the distance that the plunger translates from the sheathed state to the unsheathed state of theneedle assembly 910. In some embodiments, a distance between the primarysecond stop 821 and the secondarysecond stop 822 determines the distance that thepush pin 990 translates. In some embodiments, a distance between the primarysecond stop 821 and the secondarysecond stop 822 determines the distance that the (e.g., one or more) implant(s) 300 translate. In some embodiments, a distance between the primarysecond stop 821 and the secondarysecond stop 822 minus the length of the (e.g., one or more) implant(s) 300 determines the distance that the (e.g., one or more) implant(s) 300 is deposited into the eye of a subject. -
FIGS. 16-19 show illustrations of anexemplary injector system 1600 comprising abiopsy punch 1610. In some embodiments, thebiopsy punch 1610 comprises a modified biopsy punch formed from a commercially available biopsy punch. In some embodiments, the biopsypunch injector system 1600 comprises a commerciallyavailable needle 1620 and asheath 1670 surrounding at least a portion of theneedle 1620. As shown inFIG. 18 , the biopsypunch injector system 1600 comprises apush pin 1690 coupled to a distal surface of thebiopsy punch 1610. In some embodiments, one or more implantable medicaments is contained within theneedle 1620. In some embodiments, distal translation of thebiopsy punch 1610 translates thepush pin 1690 to eject one or more implantable medicaments out of theneedle 1620. - In some embodiments, the
needle 1620 has a gauge of 20 to 40. In some embodiments, theneedle 1620 has a gauge of 20 to 22, 20 to 24, 20 to 26, 20 to 28, 20 to 30, 20 to 32, 20 to 34, 20 to 36, 20 to 38, 20 to 40, 22 to 24, 22 to 26, 22 to 28, 22 to 30, 22 to 32, 22 to 34, 22 to 36, 22 to 38, 22 to 40, 24 to 26, 24 to 28, 24 to 30, 24 to 32, 24 to 34, 24 to 36, 24 to 38, 24 to 40, 26 to 28, 26 to 30, 26 to 32, 26 to 34, 26 to 36, 26 to 38, 26 to 40, 28 to 30, 28 to 32, 28 to 34, 28 to 36, 28 to 38, 28 to 40, 30 to 32, 30 to 34, 30 to 36, 30 to 38, 30 to 40, 32 to 34, 32 to 36, 32 to 38, 32 to 40, 34 to 36, 34 to 38, 34 to 40, 36 to 38, 36 to 40, or 38 to 40. In some embodiments, theneedle 1620 has a gauge of 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, theneedle 1620 has a gauge of at least 20, 22, 24, 26, 28, 30, 32, 34, 36, or 38. In some embodiments, theneedle 1620 has a gauge of at most 22, 24, 26, 28, 30, 32, 34, 36, 38, or 40. In some embodiments, theneedle 1620 has a gauge of 23 to 30. In some embodiments, theneedle 1620 has a gauge of 23. In some embodiments, theneedle 1620 has a gauge of 30. In some embodiments, theneedle 1620 is straight. In some embodiments, theneedle 1620 is curved. In some embodiments, thecurved needle 1620 has a curvature radius of about 10, 20, 30, 40, 50, 60, 70, 80, 90 mm or more. In some embodiments, theneedle 1620 is twisted. In some embodiments, thetwisted needle 1620 has a pitch of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more. In some embodiments, thetwisted needle 1620 has a maximum outer diameter of about 5, 10, 15, 20, 25, 30, 35, 40, 45, 50 mm or more. -
FIG. 19 shows anexemplary injector system 1600 comprising abiopsy punch 1610 and a retractableneedle seal housing 1650. As shown, the retractableneedle seal housing 1650 is slidably coupled to theneedle 1620. Further as shown, the retractableneedle seal housing 1650 translates with respect to theneedle 1620 between a sheathed state and an unsheathed state. Further, as shown the retractableneedle seal housing 1650 comprises a flange for manipulation of thesystem 1600, and aneedle seal 1671. In some embodiments, the retractableneedle seal housing 1650 comprises aneedle seal 1671 that surrounds the distal end of theneedle 1620 when thesystem 1600 is in the sheathed state. In some embodiments, the distal end of theneedle 1620 is distal to the distal face of the distal plug of theneedle seal 1671 when thesystem 1600 is in an unsheathed state. Additionally, as shown, thesheath 1670 removably attaches to the retractableneedle seal housing 1650. In some embodiments, theneedle seal 1671 of the retractableneedle seal housing 1671 is made of silicone, plastic, or any other medical grade material. -
FIGS. 20-24 show exemplary injector systems comprising asyringe 2010. PerFIG. 20 , theinjector system 2000 comprises thesyringe 2010, aneedle 1620, asheath 1670 surrounding at least a portion of theneedle 1620, and aretractable needle seal 1670 slidably coupled to theneedle 1620. In some embodiments, thesyringe 2010 comprises a 1 ml syringe. In some embodiments, thesyringe 2010 comprises a commercially available syringe. As showninjector system 2000 comprises apush pin 1690 coupled to a distal surface of thesyringe 2010. In some embodiments, one or more implantable medicaments is contained within theneedle 1620. In some embodiments, distal translation of thesyringe 2010 translates thepush pin 1690 to eject one or more implantable medicaments out of theneedle 1620. As seen inFIG. 21 , in some embodiments, thesheath 1670 and theretractable needle seal 1671 of theinjector system 2000 are a singleretainer sheath component 2150, which extends proximally beyond theneedle 1620. In some embodiments, theretainer sheath component 2150 provides an airtight seal against thesyringe 2010. -
FIG. 22 shows illustrations of anexemplary injector system 2200 comprising aneedle 2260 and removableneedle seal assembly 2250 in a sheathed state (left) and an unsheathed state (right). As shown therein, the shape of the outer surface of the hub of theneedle 2260 serves as a rail. In some embodiments, the rail has longitudinal bearing surfaces parallel to the retraction direction of the removable needle seal assembly. In some embodiments, the longitudinal bearing surface is either formed of ridges or has a cylindrical cross-sectional shape. In some embodiments, the longitudinal bearing surface enables retraction of the needle seal assembly. In some embodiments, the longitudinal bearing surface constrains against extension and retraction in directions other than parallel to the longitudinal needle lumen axis. In some embodiments, the longitudinal bearing surface enables linear retraction of the removable needle seal assembly to reduce bending loads on theneedle 2260. -
FIG. 23 shows an illustration of anotherexemplary injector system 2300 comprising a latching retainer sheath component 2350 that latches about and on to thesyringe 2010. As shown, the latching retainer sheath component 2350 couples to thesyringe 2010 by a flexure and a clip. Alternatively, in some embodiments, the latching retainer sheath component 2350 couples to thesyringe 2010 by a hinge, a screw, a nut, a slide, a clamp, a bolt, a tie, or any combination thereof. Further, perFIGS. 23 and 24 , in some embodiments, theexemplary injector system 2300 further comprises a removablepush pin retainer 2390 that prevents movement of the latching retainer sheath component 2350 with respect to theneedle 1620, when engaged. In some embodiments, the removablepush pin retainer 2390 removably couples the latching retainer sheath component 2350 to a side wall of theneedle 1620. In some embodiments, the removablepush pin retainer 2390 comprises a pin, a tie, a clip, a flexure, a switch, or any combination thereof. Further, perFIG. 24 , in some embodiments, theexemplary injector system 2300 further a commercially available syringe, comprising a distal plunger protrusion that advances thepush pin 1690 and ananti-buckling constraint 2410 that constrains the proximal push pin head within a linear path at a fixed angle parallel to the needle lumen axis. Theanti-buckling constraint 2410 prevents thepush pin 1690 from buckling during plunger, push wire, and implant advancement. In some embodiments, thesheath interface 2420 enables easier insertion of thesheath 1650 over theneedle 1620 and linear retraction of the sheath over the needle. -
FIGS. 25 shows a perspective cross-sectioned illustration of an exemplary third injector system. As seen therein, in some embodiments, an outer surface of the plunger housing has a surface treatment to improve grip.FIGS. 26-29 show front view illustrations of exemplary plungers of the third injector system.FIGS. 30-31 show front cross-sectioned and detailed view illustrations of an exemplary plunger housing of the third injector system. - One or more of the elements and features of the first injector system, the second injector system, the third injector system, and any other injector system or component described here can be used in combination with, or interchangeably between systems. In some embodiments, the first injector system, the second injector system, the third injector system, and any other injector system described here employ the needle seal, the needle sheath the secondary needle seal, the secondary needle sheath, or any combination thereof.
- Another aspect provided herein is an injector system comprising: a needle sheath; and a needle seal secured within at least a portion of the needle sheath. In some embodiments, at least a portion of the needle seal and the needle sheath are separated by a gap. In some embodiments, the portion of the needle seal is a mesial portion of the needle seal. In some embodiments, the portion of the needle seal is the portion secured within the needle sheath. In some embodiments, at least a distal portion of the needle seal extends beyond at least a distal portion of the needle sheath.
- In some embodiments, the needle seal is within a distal portion of the needle sheath. In some embodiments, the needle seal is molded within a distal portion of the needle sheath. In some embodiments, the needle seal is adhered or coupled to a distal portion of the needle sheath. In some embodiments, the needle seal is formed of a polymer. In some embodiments, the polymer is rubber, plastic, or both. In some embodiments, the needle seal is removable.
- In some embodiments, at least a distal portion of the needle seal seals at least a portion of a needle. In some embodiments, at least a distal portion of the needle seal seals at least a bevel of a needle. In some embodiments, at least a distal portion of the needle seal seals at least a majority of a bevel of a needle. In some embodiments, the needle seal is configured to seal an (e.g., one or more) implant(s) within a needle.
- In some embodiments, the needle seal comprises a distal portion, a proximal portion, and a mesial portion between the distal portion and the proximal portion. In some embodiments, the needle seal is axisymmetric. In some embodiments, an outer surface of the distal portion is generally convex. In some embodiments, an outer surface of the mesial portion is generally in the form of a conical frustum. In some embodiments, the outer surface of the proximal portion is generally cylindrical. In some embodiments, a bottom surface of the needle seal on the proximal portion comprises a divot. In some embodiments, the divot is conical. Alternatively, in some embodiments, the divot is cylindrical, a conical frustum, or any other prism. In some embodiments, an axis of symmetry of the divot is generally coaxial with the axis of symmetry of the needle seal. In some embodiments, the divot is configured to accept and/or align a needle. In some embodiments, the divot is configured to direct a needle away from compressed areas of the needle seal. In some embodiments, one or more edges of the needle seal are rounded.
- In some embodiments, the boundary between the distal portion and a first end of the mesial portion forms a distal seal lip that extends perpendicular to the axis of symmetry of the needle seal. In some embodiments, the boundary between the proximal portion and a second end of the mesial portion, opposite the first end, forms a proximal seal lip that extends perpendicular to the axis of symmetry of the needle seal.
- In some embodiments, the minimum outer diameter of the mesial portion is less than a maximum outer diameter of the distal portion. In some embodiments, the maximum outer diameter of the mesial portion is less than a maximum outer diameter of the distal portion. In some embodiments, the minimum outer diameter of the mesial portion is less than a maximum outer diameter of the proximal portion. In some embodiments, the maximum outer diameter of the mesial portion is less than a maximum outer diameter of the proximal portion.
- In some embodiments, the exemplary needle sheath is configured to accept the needle seal. In some embodiments, the exemplary needle sheath is configured to accept the needle seal such that a gap exists between the needle sheath and the mesial portion of the needle seal. In some embodiments, the gap allows the needle seal to expand when the needle is inserted therethrough. In some embodiments, the gap enables the needle sheath to securely retain the needle seal with minimal radial compression. In some embodiments, reduced radial compression prevents coring of the needle seal. In some embodiments, the gap enables air to permeate out of the needle sheath and around at least a portion of the needle seal. In some embodiments, the gap allows a needle seal to expand when the needle is inserted therethrough, to prevent coring of the needle seal. In some embodiments, a distal surface of the needle sheath is flattened to form a distal sheath seal lip that mates with the distal seal lip of the needle seal. In some embodiments, the needle sheath comprises a proximal sheath seal lip, that mates with the proximal seal lip of the of the needle seal. In some embodiments, the distal sheath seal lip and the proximal seal lip at least partially constrain translational and/or rotational movement of the needle seal with in the needle sheath.
- Another aspect provided herein is a method for injecting an (e.g., one or more) implant(s) into an eye of a patient, wherein the method comprises: providing an injector system and injecting the (e.g., one or more) implant(s) into the eye of the patient.
- In some embodiments, the system for injecting an (e.g., one or more) implant(s) into an eye of a patient has an unsheathed state and a sheathed state. In some embodiments, the system for injecting an (e.g., one or more) implant(s) into an eye of a patient comprises a needle assembly and a plunger assembly removably coupled to the needle assembly. In some embodiments, the needle assembly comprises a needle housing, a needle, and a needle lumen, the (e.g., one or more) implant(s) inside the needle lumen, and a push pin at least partially disposed within the needle lumen. In some embodiments, the plunger assembly comprises: a plunger housing and a plunger slidably disposed within the plunger housing.
- In some embodiments, injecting the (e.g., one or more) implant(s) into the eye of the patient comprises translating the plunger within the plunger housing to engage the push pin and translate the push pin within the needle such that a distal surface of the needle contacts the (e.g., one or more) implant(s) and translates the (e.g., one or more) implant(s) out of the needle and into the eye of the patient.
- The following illustrative examples are representative of embodiments of the devices and methods described herein and are not meant to be limiting in any way. In one example, the needle housing is received with the (e.g., one or more) implant(s) and within the needle. A technician or medical practitioner then attaches the needle housing to the plunger assembly. During operation, the medical practitioner unsheathes the needle assembly and inserts the needle into the eye of the patient until the distal portion of the needle sheath abuts against the eye of the patient. The technician then applies a distal force to the plunger to decouple the first stop feature from the primary second stop feature. The distal force distally translates the plunger such that distal portion of the plunger distally translates the push pin, which translates the (e.g., one or more) implant(s) within the needle into the eye of the patient. Once the first stop feature is decoupled from and distal to the secondary stop feature, the distal force is released, wherein the push pin retracts proximally, and the first stop feature couples to the secondary stop feature. The medical practitioner then removes the needle from the eye of the patient.
- While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure.
- Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.
- As used herein, the term “biopsy punch” refers to a sharp, hollow, circular instrument for extracting a round piece of tissue.
- As used herein, the term “proximal” refers to a direction towards the user of the device and away from the patient.
- As used herein, the term “distal” refers to a direction away from the user of the device and towards the patient.
- As used herein, the term “lumen” refers to the hollow portion of a needle in which a medicament is transferred.
- As used herein, the singular forms “a,” “an,” and “the” include plural references unless the context clearly dictates otherwise. Any reference to “or” herein is intended to encompass “and/or” unless otherwise stated.
- As used herein, the term “about” refers to an amount that is near the stated amount by 10%, 5%, or 1%, including increments therein.
- As used herein, the term “about” in reference to a percentage refers to an amount that is greater or less the stated percentage by 10%, 5%, or 1%, including increments therein.
- As used herein, the phrases “at least one”, “one or more”, and “and/or” are open-ended expressions that are both conjunctive and disjunctive in operation. For example, each of the expressions “at least one of A, B and C”, “at least one of A, B, or C”, “one or more of A, B, and C”, “one or more of A, B, or C” and “A, B, and/or C” means A alone, B alone, C alone, A and B together, A and C together, B and C together, or A, B and C together.
- While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure.
Claims (21)
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- 2020-02-21 US US16/798,219 patent/US11464914B2/en active Active
- 2020-10-20 CA CA3158374A patent/CA3158374A1/en active Pending
- 2020-10-20 JP JP2022523820A patent/JP2022553068A/en active Pending
- 2020-10-20 EP EP20878325.8A patent/EP4048213A4/en active Pending
- 2020-10-20 WO PCT/IB2020/000875 patent/WO2021079189A1/en unknown
- 2020-10-20 MX MX2022004755A patent/MX2022004755A/en unknown
- 2020-10-20 US US17/770,184 patent/US20220387213A1/en active Pending
- 2020-10-20 CN CN202080088755.5A patent/CN114845671A/en active Pending
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2022
- 2022-09-01 US US17/929,141 patent/US20230113525A1/en active Pending
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CA3158374A1 (en) | 2021-04-29 |
US20210113780A1 (en) | 2021-04-22 |
CN114845671A (en) | 2022-08-02 |
US11464914B2 (en) | 2022-10-11 |
MX2022004755A (en) | 2022-08-04 |
EP4048213A1 (en) | 2022-08-31 |
EP4048213A4 (en) | 2023-11-29 |
JP2022553068A (en) | 2022-12-21 |
US20230113525A1 (en) | 2023-04-13 |
WO2021079189A1 (en) | 2021-04-29 |
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