US20220348577A1 - CXCR4 Receptor Antagonists - Google Patents
CXCR4 Receptor Antagonists Download PDFInfo
- Publication number
- US20220348577A1 US20220348577A1 US17/190,266 US202117190266A US2022348577A1 US 20220348577 A1 US20220348577 A1 US 20220348577A1 US 202117190266 A US202117190266 A US 202117190266A US 2022348577 A1 US2022348577 A1 US 2022348577A1
- Authority
- US
- United States
- Prior art keywords
- alkyl
- fluoro
- alkoxy
- mmol
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010061299 CXCR4 Receptors Proteins 0.000 title abstract description 11
- 102000012000 CXCR4 Receptors Human genes 0.000 title abstract description 11
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 319
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 195
- -1 isopropylmethyl Chemical group 0.000 claims description 139
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 55
- 125000001424 substituent group Chemical group 0.000 claims description 55
- 125000000623 heterocyclic group Chemical group 0.000 claims description 49
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 42
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 40
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 37
- 125000001072 heteroaryl group Chemical group 0.000 claims description 36
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 34
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 33
- 229910052731 fluorine Inorganic materials 0.000 claims description 33
- 239000011737 fluorine Substances 0.000 claims description 33
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 29
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 29
- 229910052736 halogen Inorganic materials 0.000 claims description 28
- 150000002367 halogens Chemical class 0.000 claims description 28
- 125000006555 (C3-C5) cycloalkyl group Chemical group 0.000 claims description 26
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 21
- 239000001257 hydrogen Substances 0.000 claims description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims description 20
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 19
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 19
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 15
- 125000001153 fluoro group Chemical group F* 0.000 claims description 13
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 13
- 150000002431 hydrogen Chemical group 0.000 claims description 12
- 150000003254 radicals Chemical class 0.000 claims description 10
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 9
- 208000036142 Viral infection Diseases 0.000 claims description 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000004076 pyridyl group Chemical group 0.000 claims description 8
- 230000009385 viral infection Effects 0.000 claims description 8
- 208000030507 AIDS Diseases 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000001041 indolyl group Chemical group 0.000 claims description 7
- 125000006413 ring segment Chemical group 0.000 claims description 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000000335 thiazolyl group Chemical group 0.000 claims description 6
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 5
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 5
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 3
- FEIACFYXEWBKHU-UHFFFAOYSA-N (2-aminopyridin-3-yl)methanol Chemical compound NC1=NC=CC=C1CO FEIACFYXEWBKHU-UHFFFAOYSA-N 0.000 claims description 2
- 125000004776 1-fluoroethyl group Chemical group [H]C([H])([H])C([H])(F)* 0.000 claims description 2
- OBYVIVUJQDGTKI-RIUYPTKQSA-N 2-[[(2R,3S,4S,5R,6R)-3,5-dihydroxy-2-(hydroxymethyl)-6-methoxyoxan-4-yl]oxymethyl]quinoline-7-carboxylic acid Chemical compound CO[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)CO)O)OCC2=NC3=C(C=CC(=C3)C(=O)O)C=C2)O OBYVIVUJQDGTKI-RIUYPTKQSA-N 0.000 claims description 2
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims description 2
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 claims description 2
- 125000000068 chlorophenyl group Chemical group 0.000 claims description 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 2
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims description 2
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 claims description 2
- 125000006223 tetrahydrofuranylmethyl group Chemical group 0.000 claims description 2
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 claims description 2
- 125000006173 tetrahydropyranylmethyl group Chemical group 0.000 claims description 2
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- 125000005348 fluorocycloalkyl group Chemical group 0.000 claims 1
- 239000005557 antagonist Substances 0.000 abstract description 10
- 239000000543 intermediate Substances 0.000 description 568
- 238000004128 high performance liquid chromatography Methods 0.000 description 284
- 239000011541 reaction mixture Substances 0.000 description 236
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 234
- YMWUJEATGCHHMB-UHFFFAOYSA-N dichloromethane Natural products ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 232
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 176
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 143
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 117
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 99
- 229910000029 sodium carbonate Inorganic materials 0.000 description 88
- 239000002904 solvent Substances 0.000 description 84
- 239000007787 solid Substances 0.000 description 70
- 238000004440 column chromatography Methods 0.000 description 65
- 244000166102 Eucalyptus leucoxylon Species 0.000 description 53
- 235000004694 Eucalyptus leucoxylon Nutrition 0.000 description 53
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 53
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 50
- 238000004007 reversed phase HPLC Methods 0.000 description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 46
- 239000012267 brine Substances 0.000 description 40
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 40
- 238000011282 treatment Methods 0.000 description 40
- 210000000130 stem cell Anatomy 0.000 description 39
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 37
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 36
- 206010028980 Neoplasm Diseases 0.000 description 34
- 0 [1*]C[Y][2*] Chemical compound [1*]C[Y][2*] 0.000 description 34
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 33
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 31
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 30
- 239000007788 liquid Substances 0.000 description 27
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Substances OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 27
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 25
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 24
- 241000725303 Human immunodeficiency virus Species 0.000 description 24
- 210000004027 cell Anatomy 0.000 description 24
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 23
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 22
- 230000003394 haemopoietic effect Effects 0.000 description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 19
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 18
- 201000011510 cancer Diseases 0.000 description 18
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 18
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 18
- 239000000243 solution Substances 0.000 description 18
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 description 17
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 17
- 238000005932 reductive alkylation reaction Methods 0.000 description 17
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 17
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 16
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 16
- 239000003921 oil Substances 0.000 description 16
- 235000019198 oils Nutrition 0.000 description 16
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 16
- 125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 16
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 15
- 235000019439 ethyl acetate Nutrition 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 15
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 15
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 14
- 229940121384 cxc chemokine receptor type 4 (cxcr4) antagonist Drugs 0.000 description 14
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclopentanone Chemical compound O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 description 14
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 13
- 238000010521 absorption reaction Methods 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 13
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 12
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium on carbon Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 239000000203 mixture Substances 0.000 description 12
- 208000033808 peripheral neuropathy Diseases 0.000 description 12
- 235000011121 sodium hydroxide Nutrition 0.000 description 12
- CCDBCHAQIXKJCG-UHFFFAOYSA-N 1-propan-2-ylpiperidin-4-one Chemical compound CC(C)N1CCC(=O)CC1 CCDBCHAQIXKJCG-UHFFFAOYSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 description 11
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 10
- 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 description 10
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 10
- 241000713772 Human immunodeficiency virus 1 Species 0.000 description 10
- 239000012948 isocyanate Substances 0.000 description 10
- 150000002513 isocyanates Chemical class 0.000 description 10
- 210000000265 leukocyte Anatomy 0.000 description 10
- 238000010992 reflux Methods 0.000 description 10
- 239000011347 resin Substances 0.000 description 10
- 229920005989 resin Polymers 0.000 description 10
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 10
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 9
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide Substances CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 9
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 9
- 239000002253 acid Substances 0.000 description 9
- 238000002617 apheresis Methods 0.000 description 9
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 9
- 201000001119 neuropathy Diseases 0.000 description 9
- 230000007823 neuropathy Effects 0.000 description 9
- 229910000027 potassium carbonate Inorganic materials 0.000 description 9
- 238000001959 radiotherapy Methods 0.000 description 9
- 230000002441 reversible effect Effects 0.000 description 9
- ROUYFJUVMYHXFJ-UHFFFAOYSA-N tert-butyl 4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)CC1 ROUYFJUVMYHXFJ-UHFFFAOYSA-N 0.000 description 9
- ZLKMOIHCHCMSFW-UHFFFAOYSA-N 6-chloropyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(Cl)=N1 ZLKMOIHCHCMSFW-UHFFFAOYSA-N 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 8
- 239000007858 starting material Substances 0.000 description 8
- 125000004793 2,2,2-trifluoroethoxy group Chemical group FC(CO*)(F)F 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 206010027476 Metastases Diseases 0.000 description 7
- 206010055666 Retinal neovascularisation Diseases 0.000 description 7
- 229910021529 ammonia Inorganic materials 0.000 description 7
- 239000004037 angiogenesis inhibitor Substances 0.000 description 7
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 7
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 7
- 230000006378 damage Effects 0.000 description 7
- 230000009401 metastasis Effects 0.000 description 7
- 125000006239 protecting group Chemical group 0.000 description 7
- NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 7
- KMQWNQKESAHDKD-UHFFFAOYSA-N 2-chloro-4-fluorobenzaldehyde Chemical compound FC1=CC=C(C=O)C(Cl)=C1 KMQWNQKESAHDKD-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 description 6
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 206010012689 Diabetic retinopathy Diseases 0.000 description 6
- 229910010084 LiAlH4 Inorganic materials 0.000 description 6
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 6
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 6
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 6
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 6
- 150000001412 amines Chemical class 0.000 description 6
- 238000003556 assay Methods 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 238000002512 chemotherapy Methods 0.000 description 6
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 6
- IGSKHXTUVXSOMB-UHFFFAOYSA-N cyclopropylmethanamine Chemical compound NCC1CC1 IGSKHXTUVXSOMB-UHFFFAOYSA-N 0.000 description 6
- CSJLBAMHHLJAAS-UHFFFAOYSA-N diethylaminosulfur trifluoride Chemical compound CCN(CC)S(F)(F)F CSJLBAMHHLJAAS-UHFFFAOYSA-N 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 6
- 239000012280 lithium aluminium hydride Substances 0.000 description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 6
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 6
- 238000003786 synthesis reaction Methods 0.000 description 6
- JZNWQLLPLOQGOI-UHFFFAOYSA-N tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(=O)C(F)C1 JZNWQLLPLOQGOI-UHFFFAOYSA-N 0.000 description 6
- VRJHQPZVIGNGMX-UHFFFAOYSA-N 4-piperidinone Chemical compound O=C1CCNCC1 VRJHQPZVIGNGMX-UHFFFAOYSA-N 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 5
- QLPKBHYPNYEXPZ-UHFFFAOYSA-N Cc1cc2ncccc2n1C(=O)OC(C)(C)C Chemical compound Cc1cc2ncccc2n1C(=O)OC(C)(C)C QLPKBHYPNYEXPZ-UHFFFAOYSA-N 0.000 description 5
- 208000034578 Multiple myelomas Diseases 0.000 description 5
- 206010029260 Neuroblastoma Diseases 0.000 description 5
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 5
- 206010035226 Plasma cell myeloma Diseases 0.000 description 5
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 5
- 206010064930 age-related macular degeneration Diseases 0.000 description 5
- 229940120638 avastin Drugs 0.000 description 5
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 5
- MUALRAIOVNYAIW-UHFFFAOYSA-N binap Chemical compound C1=CC=CC=C1P(C=1C(=C2C=CC=CC2=CC=1)C=1C2=CC=CC=C2C=CC=1P(C=1C=CC=CC=1)C=1C=CC=CC=1)C1=CC=CC=C1 MUALRAIOVNYAIW-UHFFFAOYSA-N 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 5
- 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 description 5
- 125000002883 imidazolyl group Chemical group 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 208000002780 macular degeneration Diseases 0.000 description 5
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 5
- 125000002950 monocyclic group Chemical group 0.000 description 5
- ZUSSTQCWRDLYJA-UHFFFAOYSA-N n-hydroxy-5-norbornene-2,3-dicarboximide Chemical compound C1=CC2CC1C1C2C(=O)N(O)C1=O ZUSSTQCWRDLYJA-UHFFFAOYSA-N 0.000 description 5
- 125000001715 oxadiazolyl group Chemical group 0.000 description 5
- 125000002971 oxazolyl group Chemical group 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- 239000000377 silicon dioxide Substances 0.000 description 5
- 239000012453 solvate Substances 0.000 description 5
- 125000003831 tetrazolyl group Chemical group 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- UKGJZDSUJSPAJL-YPUOHESYSA-N (e)-n-[(1r)-1-[3,5-difluoro-4-(methanesulfonamido)phenyl]ethyl]-3-[2-propyl-6-(trifluoromethyl)pyridin-3-yl]prop-2-enamide Chemical compound CCCC1=NC(C(F)(F)F)=CC=C1\C=C\C(=O)N[C@H](C)C1=CC(F)=C(NS(C)(=O)=O)C(F)=C1 UKGJZDSUJSPAJL-YPUOHESYSA-N 0.000 description 4
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 description 4
- XYIMUBJXPVXFMF-MRVPVSSYSA-N 1-[(2r)-butan-2-yl]piperidin-4-one Chemical compound CC[C@@H](C)N1CCC(=O)CC1 XYIMUBJXPVXFMF-MRVPVSSYSA-N 0.000 description 4
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 4
- YBYIRNPNPLQARY-UHFFFAOYSA-N 1H-indene Natural products C1=CC=C2CC=CC2=C1 YBYIRNPNPLQARY-UHFFFAOYSA-N 0.000 description 4
- BEGREHRAUWCAHV-UHFFFAOYSA-N 2-bromo-1,3-thiazole-4-carboxylic acid Chemical compound OC(=O)C1=CSC(Br)=N1 BEGREHRAUWCAHV-UHFFFAOYSA-N 0.000 description 4
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 description 4
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 4
- VJPPLCNBDLZIFG-ZDUSSCGKSA-N 4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide Chemical compound C(C#CC)(=O)N[C@@H]1CN(CCC1)C1=C2C(=C(NC2=C(C=C1F)C(=O)N)C)C VJPPLCNBDLZIFG-ZDUSSCGKSA-N 0.000 description 4
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 4
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 4
- 150000001204 N-oxides Chemical class 0.000 description 4
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 4
- 241000700605 Viruses Species 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 4
- 238000002832 anti-viral assay Methods 0.000 description 4
- 230000000840 anti-viral effect Effects 0.000 description 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 4
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 4
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 description 4
- 108010005774 beta-Galactosidase Proteins 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 4
- 208000025698 brain inflammatory disease Diseases 0.000 description 4
- VQFAIAKCILWQPZ-UHFFFAOYSA-N bromoacetone Chemical compound CC(=O)CBr VQFAIAKCILWQPZ-UHFFFAOYSA-N 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 150000001728 carbonyl compounds Chemical class 0.000 description 4
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 4
- 239000003937 drug carrier Substances 0.000 description 4
- 206010014599 encephalitis Diseases 0.000 description 4
- 125000002541 furyl group Chemical group 0.000 description 4
- 238000003306 harvesting Methods 0.000 description 4
- 150000004677 hydrates Chemical class 0.000 description 4
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 4
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 description 4
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 description 4
- 125000003387 indolinyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 description 4
- 208000014674 injury Diseases 0.000 description 4
- 125000004594 isoindolinyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 description 4
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 description 4
- 125000006229 isopropoxyethyl group Chemical group [H]C([H])([H])C([H])(OC([H])([H])C([H])([H])*)C([H])([H])[H] 0.000 description 4
- 125000001786 isothiazolyl group Chemical group 0.000 description 4
- 125000000842 isoxazolyl group Chemical group 0.000 description 4
- 230000001404 mediated effect Effects 0.000 description 4
- 210000003643 myeloid progenitor cell Anatomy 0.000 description 4
- 239000008194 pharmaceutical composition Substances 0.000 description 4
- DNUTZBZXLPWRJG-UHFFFAOYSA-M piperidine-1-carboxylate Chemical compound [O-]C(=O)N1CCCCC1 DNUTZBZXLPWRJG-UHFFFAOYSA-M 0.000 description 4
- 125000003386 piperidinyl group Chemical group 0.000 description 4
- 125000003373 pyrazinyl group Chemical group 0.000 description 4
- 125000003226 pyrazolyl group Chemical group 0.000 description 4
- 125000002098 pyridazinyl group Chemical group 0.000 description 4
- 150000003222 pyridines Chemical class 0.000 description 4
- 125000000714 pyrimidinyl group Chemical group 0.000 description 4
- 125000000168 pyrrolyl group Chemical group 0.000 description 4
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 description 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 4
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- DVPHJLOQDYBPAW-UHFFFAOYSA-N tert-butyl 6-chloropyridine-2-carboxylate Chemical compound CC(C)(C)OC(=O)C1=CC=CC(Cl)=N1 DVPHJLOQDYBPAW-UHFFFAOYSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 125000001113 thiadiazolyl group Chemical group 0.000 description 4
- 125000001544 thienyl group Chemical group 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
- CXNIUSPIQKWYAI-UHFFFAOYSA-N xantphos Chemical compound C=12OC3=C(P(C=4C=CC=CC=4)C=4C=CC=CC=4)C=CC=C3C(C)(C)C2=CC=CC=1P(C=1C=CC=CC=1)C1=CC=CC=C1 CXNIUSPIQKWYAI-UHFFFAOYSA-N 0.000 description 4
- JTJTYCPQUOROFM-UHFFFAOYSA-N 1-benzyl-1,4-diazepane Chemical compound C=1C=CC=CC=1CN1CCCNCC1 JTJTYCPQUOROFM-UHFFFAOYSA-N 0.000 description 3
- MSWVMWGCNZQPIA-UHFFFAOYSA-N 1-fluoropropan-2-one Chemical compound CC(=O)CF MSWVMWGCNZQPIA-UHFFFAOYSA-N 0.000 description 3
- RXNZFHIEDZEUQM-UHFFFAOYSA-N 2-bromo-1,3-thiazole Chemical compound BrC1=NC=CS1 RXNZFHIEDZEUQM-UHFFFAOYSA-N 0.000 description 3
- LSAOLINSZGYDOV-UHFFFAOYSA-N 2-chloro-6-iodopyridine Chemical compound ClC1=CC=CC(I)=N1 LSAOLINSZGYDOV-UHFFFAOYSA-N 0.000 description 3
- FPYUJUBAXZAQNL-UHFFFAOYSA-N 2-chlorobenzaldehyde Chemical compound ClC1=CC=CC=C1C=O FPYUJUBAXZAQNL-UHFFFAOYSA-N 0.000 description 3
- KDHWOCLBMVSZPG-UHFFFAOYSA-N 3-imidazol-1-ylpropan-1-amine Chemical compound NCCCN1C=CN=C1 KDHWOCLBMVSZPG-UHFFFAOYSA-N 0.000 description 3
- NUKYPUAOHBNCPY-UHFFFAOYSA-N 4-aminopyridine Chemical compound NC1=CC=NC=C1 NUKYPUAOHBNCPY-UHFFFAOYSA-N 0.000 description 3
- XNUNVQKARNSSEO-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 XNUNVQKARNSSEO-UHFFFAOYSA-N 0.000 description 3
- FZEVQQVXLVETSV-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(1,3-oxazol-2-ylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC=2OC=CN=2)CC1 FZEVQQVXLVETSV-UHFFFAOYSA-N 0.000 description 3
- GIVBFKYXAXLZBT-UHFFFAOYSA-N 6-chloropyridine-2-carboxamide Chemical compound NC(=O)C1=CC=CC(Cl)=N1 GIVBFKYXAXLZBT-UHFFFAOYSA-N 0.000 description 3
- XTJYECULYBIMID-UHFFFAOYSA-N 6-chloropyridine-2-carboximidamide Chemical compound NC(=N)C1=CC=CC(Cl)=N1 XTJYECULYBIMID-UHFFFAOYSA-N 0.000 description 3
- RIAHASMJDOMQER-UHFFFAOYSA-N CCc1cnc(C)[nH]1 Chemical compound CCc1cnc(C)[nH]1 RIAHASMJDOMQER-UHFFFAOYSA-N 0.000 description 3
- HCUFKIUYBRJORR-UHFFFAOYSA-N CNc1ccnc(C)c1 Chemical compound CNc1ccnc(C)c1 HCUFKIUYBRJORR-UHFFFAOYSA-N 0.000 description 3
- KXKVLQRXCPHEJC-UHFFFAOYSA-N COC(C)=O Chemical compound COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- UTUSYSDVLOWRJA-UHFFFAOYSA-N Cc1ncc(C(F)(F)F)[nH]1 Chemical compound Cc1ncc(C(F)(F)F)[nH]1 UTUSYSDVLOWRJA-UHFFFAOYSA-N 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 3
- 108090000695 Cytokines Proteins 0.000 description 3
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 3
- 241000400611 Eucalyptus deanei Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 3
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 239000002147 L01XE04 - Sunitinib Substances 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- IDRGFNPZDVBSSE-UHFFFAOYSA-N OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F Chemical compound OCCN1CCN(CC1)c1ccc(Nc2ncc3cccc(-c4cccc(NC(=O)C=C)c4)c3n2)c(F)c1F IDRGFNPZDVBSSE-UHFFFAOYSA-N 0.000 description 3
- 108091008606 PDGF receptors Proteins 0.000 description 3
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 150000007513 acids Chemical class 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical group C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 description 3
- 125000002393 azetidinyl group Chemical group 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 229910000024 caesium carbonate Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 239000002576 chemokine receptor CXCR4 antagonist Substances 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 description 3
- 238000010511 deprotection reaction Methods 0.000 description 3
- 229910052805 deuterium Inorganic materials 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- QPMLSUSACCOBDK-UHFFFAOYSA-N diazepane Chemical compound C1CCNNCC1 QPMLSUSACCOBDK-UHFFFAOYSA-N 0.000 description 3
- 235000013681 dietary sucrose Nutrition 0.000 description 3
- 125000000532 dioxanyl group Chemical group 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 229960004979 fampridine Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000003102 growth factor Substances 0.000 description 3
- 150000002430 hydrocarbons Chemical group 0.000 description 3
- USZLCYNVCCDPLQ-UHFFFAOYSA-N hydron;n-methoxymethanamine;chloride Chemical compound Cl.CNOC USZLCYNVCCDPLQ-UHFFFAOYSA-N 0.000 description 3
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 150000002576 ketones Chemical class 0.000 description 3
- 239000002480 mineral oil Substances 0.000 description 3
- 235000010446 mineral oil Nutrition 0.000 description 3
- 125000002757 morpholinyl group Chemical group 0.000 description 3
- PSRYOOFOGQKUPJ-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-(1-ethylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(CC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 PSRYOOFOGQKUPJ-UHFFFAOYSA-N 0.000 description 3
- SAKTYHHWBVGBGB-OAQYLSRUSA-N n-(cyclopropylmethyl)-6-[4-[1-[(1r)-1-(4-fluorophenyl)ethyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN([C@H](C)C=2C=CC(F)=CC=2)CCC1N(CC1)CCCN1C(N=1)=CC=CC=1C(=O)NCC1CC1 SAKTYHHWBVGBGB-OAQYLSRUSA-N 0.000 description 3
- KCGDIPHRRPJODH-UHFFFAOYSA-N n-[2-(3,5-dimethylpyrazol-1-yl)-6,6-dimethyl-5,8-dihydropyrano[4,5]thieno[1,2-c]pyrimidin-4-yl]-n',n'-diethylpropane-1,3-diamine Chemical compound N=1C=2SC=3COC(C)(C)CC=3C=2C(NCCCN(CC)CC)=NC=1N1N=C(C)C=C1C KCGDIPHRRPJODH-UHFFFAOYSA-N 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 125000003566 oxetanyl group Chemical group 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 3
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 3
- 210000005259 peripheral blood Anatomy 0.000 description 3
- 239000011886 peripheral blood Substances 0.000 description 3
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 3
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 description 3
- 125000004193 piperazinyl group Chemical group 0.000 description 3
- 230000003389 potentiating effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000006722 reduction reaction Methods 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 3
- 238000011476 stem cell transplantation Methods 0.000 description 3
- 229960004793 sucrose Drugs 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- FJYBLMJHXRWDAQ-QMMMGPOBSA-N tert-butyl (2s)-2-(hydroxymethyl)morpholine-4-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCO[C@H](CO)C1 FJYBLMJHXRWDAQ-QMMMGPOBSA-N 0.000 description 3
- LWKMTSRRGUVABD-UHFFFAOYSA-N tert-butyl 2-formylmorpholine-4-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCOC(C=O)C1 LWKMTSRRGUVABD-UHFFFAOYSA-N 0.000 description 3
- AKQXKEBCONUWCL-UHFFFAOYSA-N tert-butyl 3-aminopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(N)C1 AKQXKEBCONUWCL-UHFFFAOYSA-N 0.000 description 3
- PMLBUVZPRKXMOX-UHFFFAOYSA-N tert-butyl 4-oxoazepane-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(=O)CC1 PMLBUVZPRKXMOX-UHFFFAOYSA-N 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 238000004809 thin layer chromatography Methods 0.000 description 3
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 230000004862 vasculogenesis Effects 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- WCWUXEGQKLTGDX-LLVKDONJSA-N (2R)-1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol Chemical compound C1=C2NC(C)=CC2=C(F)C(OC2=NC=NN3C=C(C(=C32)C)OC[C@H](O)C)=C1 WCWUXEGQKLTGDX-LLVKDONJSA-N 0.000 description 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 2
- KCOYQXZDFIIGCY-CZIZESTLSA-N (3e)-4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one Chemical compound C1CN(C)CCN1C1=CC=C(N\C(N2)=C/3C(=C4C(F)=CC=CC4=NC\3=O)N)C2=C1 KCOYQXZDFIIGCY-CZIZESTLSA-N 0.000 description 2
- HRMRQBJUFWFQLX-SSDOTTSWSA-N (3r)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CC[C@@H](C(O)=O)C1 HRMRQBJUFWFQLX-SSDOTTSWSA-N 0.000 description 2
- OBPZDTVOCFDXBS-GFCCVEGCSA-N (3r)-1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-amine Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2C[C@H](N)CC2)NC=1C1CC1 OBPZDTVOCFDXBS-GFCCVEGCSA-N 0.000 description 2
- BNAHKOUMFHJYSL-LLVKDONJSA-N (3r)-1-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-amine Chemical compound C1[C@H](N)CCN1C1=CC=CC(C=2NC(=CN=2)C2CC2)=N1 BNAHKOUMFHJYSL-LLVKDONJSA-N 0.000 description 2
- RKYBCEKZTZJUPE-WOJBJXKFSA-N (3r)-1-cyclopentyl-n-[(3r)-1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl]pyrrolidine-3-carboxamide Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2C[C@@H](CC2)NC(=O)[C@H]2CN(CC2)C2CCCC2)NC=1C1CC1 RKYBCEKZTZJUPE-WOJBJXKFSA-N 0.000 description 2
- LRYVZGVKDOMIKF-HZPDHXFCSA-N (3r)-n-[(3r)-1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl]pyrrolidine-3-carboxamide Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2C[C@@H](CC2)NC(=O)[C@H]2CNCC2)NC=1C1CC1 LRYVZGVKDOMIKF-HZPDHXFCSA-N 0.000 description 2
- UUCZFULDFFWPQL-PZJWPPBQSA-N (3r)-n-[[(3s)-1-cyclopentylpyrrolidin-3-yl]methyl]-1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-amine Chemical compound CC=1NC(C=2N=C(C=CC=2)N2C[C@@H](CC2)NC[C@H]2CN(CC2)C2CCCC2)=NC=1C1CC1 UUCZFULDFFWPQL-PZJWPPBQSA-N 0.000 description 2
- RKYBCEKZTZJUPE-VQTJNVASSA-N (3s)-1-cyclopentyl-n-[(3r)-1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl]pyrrolidine-3-carboxamide Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2C[C@@H](CC2)NC(=O)[C@@H]2CN(CC2)C2CCCC2)NC=1C1CC1 RKYBCEKZTZJUPE-VQTJNVASSA-N 0.000 description 2
- JZKBQBYSZMMNLW-UHFFFAOYSA-N (4-benzyl-1,4-diazepan-1-yl)-(1-methyl-4-propan-2-ylpiperazin-2-yl)methanone Chemical compound C1N(C(C)C)CCN(C)C1C(=O)N1CCN(CC=2C=CC=CC=2)CCC1 JZKBQBYSZMMNLW-UHFFFAOYSA-N 0.000 description 2
- QJYYLAIFSCLBOV-CZIZESTLSA-N (e)-3-(dimethylamino)-2-methyl-1-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]prop-2-en-1-one Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)C(\C)=C\N(C)C)CCC1 QJYYLAIFSCLBOV-CZIZESTLSA-N 0.000 description 2
- SKKXZAXLYWERGC-UHFFFAOYSA-N 1,1-difluoropropan-2-amine Chemical compound CC(N)C(F)F SKKXZAXLYWERGC-UHFFFAOYSA-N 0.000 description 2
- KTUQSPQZBWVGDH-UHFFFAOYSA-N 1-(1,1,1-trifluoro-2-methylpropan-2-yl)piperidin-4-one Chemical compound FC(F)(F)C(C)(C)N1CCC(=O)CC1 KTUQSPQZBWVGDH-UHFFFAOYSA-N 0.000 description 2
- TTXVCLHAQPSHJR-UHFFFAOYSA-N 1-(1,1-difluoropropan-2-yl)piperidin-4-one Chemical compound FC(F)C(C)N1CCC(=O)CC1 TTXVCLHAQPSHJR-UHFFFAOYSA-N 0.000 description 2
- ILKHNQYYKXFVMD-UHFFFAOYSA-N 1-(1,3-difluoropropan-2-yl)piperidin-4-one Chemical compound FCC(CF)N1CCC(=O)CC1 ILKHNQYYKXFVMD-UHFFFAOYSA-N 0.000 description 2
- PTRSCUBZJLQOPV-UHFFFAOYSA-N 1-(1-cyclopentyl-3-fluoropiperidin-4-yl)-4-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound CC=1NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2C(CN(CC2)C2CCCC2)F)=NC=1C1CC1 PTRSCUBZJLQOPV-UHFFFAOYSA-N 0.000 description 2
- UQLPAVWSWVEDIJ-UHFFFAOYSA-N 1-(1-fluoropropan-2-yl)piperidin-4-one Chemical compound FCC(C)N1CCC(=O)CC1 UQLPAVWSWVEDIJ-UHFFFAOYSA-N 0.000 description 2
- FYCCVNATFAGBNI-UHFFFAOYSA-N 1-(1-propan-2-ylpiperidin-4-yl)-4-[6-(2h-tetrazol-5-yl)pyridin-2-yl]-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C2=NNN=N2)CCC1 FYCCVNATFAGBNI-UHFFFAOYSA-N 0.000 description 2
- XSGUHURKMVYODF-UHFFFAOYSA-N 1-(1-propan-2-ylpiperidin-4-yl)-4-[6-(5-propyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound CCCC1=CNC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 XSGUHURKMVYODF-UHFFFAOYSA-N 0.000 description 2
- HWWUCLRTZIRXFQ-UHFFFAOYSA-N 1-(1-propan-2-ylpiperidin-4-yl)-4-[6-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridin-2-yl]-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(N=2)C(F)(F)F)CCC1 HWWUCLRTZIRXFQ-UHFFFAOYSA-N 0.000 description 2
- PDEXNHMYUXJIIL-UHFFFAOYSA-N 1-(2-fluorocyclopentyl)piperidin-4-one Chemical compound FC1CCCC1N1CCC(=O)CC1 PDEXNHMYUXJIIL-UHFFFAOYSA-N 0.000 description 2
- TZBGCFOBLIWBSM-UHFFFAOYSA-N 1-(2-methoxyethyl)piperidin-4-one Chemical compound COCCN1CCC(=O)CC1 TZBGCFOBLIWBSM-UHFFFAOYSA-N 0.000 description 2
- OWFKKIWJZOAEQE-UHFFFAOYSA-N 1-(3-fluoro-1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound FC1CN(C(C)C)CCC1N1CCNCCC1 OWFKKIWJZOAEQE-UHFFFAOYSA-N 0.000 description 2
- YWEZPWKOJVDFRJ-UHFFFAOYSA-N 1-(4,4,4-trifluorobutan-2-yl)piperidin-4-one Chemical compound FC(F)(F)CC(C)N1CCC(=O)CC1 YWEZPWKOJVDFRJ-UHFFFAOYSA-N 0.000 description 2
- LNZXKLFGXWIUDU-UHFFFAOYSA-N 1-(4-benzyl-1,4-diazepan-1-yl)-2-(4-propan-2-ylmorpholin-3-yl)ethanone Chemical compound CC(C)N1CCOCC1CC(=O)N1CCN(CC=2C=CC=CC=2)CCC1 LNZXKLFGXWIUDU-UHFFFAOYSA-N 0.000 description 2
- OBNWZRXHPJTOEH-UHFFFAOYSA-N 1-(4-methylpyridin-2-yl)-1,4-diazepane Chemical compound CC1=CC=NC(N2CCNCCC2)=C1 OBNWZRXHPJTOEH-UHFFFAOYSA-N 0.000 description 2
- FGUAAOSYEWGFGV-UHFFFAOYSA-N 1-(4-methylpyridin-2-yl)-4-piperidin-4-yl-1,4-diazepane Chemical compound CC1=CC=NC(N2CCN(CCC2)C2CCNCC2)=C1 FGUAAOSYEWGFGV-UHFFFAOYSA-N 0.000 description 2
- SMKRVCKHWYQEGX-UHFFFAOYSA-N 1-(5-methylpyridin-2-yl)-1,4-diazepane Chemical compound N1=CC(C)=CC=C1N1CCNCCC1 SMKRVCKHWYQEGX-UHFFFAOYSA-N 0.000 description 2
- HJHYBBPGKMXZQF-UHFFFAOYSA-N 1-(5-methylpyridin-2-yl)-4-piperidin-4-yl-1,4-diazepane Chemical compound N1=CC(C)=CC=C1N1CCN(C2CCNCC2)CCC1 HJHYBBPGKMXZQF-UHFFFAOYSA-N 0.000 description 2
- JKXRJULPFYHASQ-UHFFFAOYSA-N 1-(6-methylpyridin-2-yl)-1,4-diazepane Chemical compound CC1=CC=CC(N2CCNCCC2)=N1 JKXRJULPFYHASQ-UHFFFAOYSA-N 0.000 description 2
- JLBQVGVACQPOLN-UHFFFAOYSA-N 1-(6-methylpyridin-2-yl)-4-piperidin-4-yl-1,4-diazepane Chemical compound CC1=CC=CC(N2CCN(CCC2)C2CCNCC2)=N1 JLBQVGVACQPOLN-UHFFFAOYSA-N 0.000 description 2
- YHZMFUMZNVMKIP-UHFFFAOYSA-N 1-[(1-methyl-4-propan-2-ylpiperazin-2-yl)methyl]-1,4-diazepane Chemical compound C1N(C(C)C)CCN(C)C1CN1CCNCCC1 YHZMFUMZNVMKIP-UHFFFAOYSA-N 0.000 description 2
- JPLYVJGTOBCVEW-SNVBAGLBSA-N 1-[(1r)-1-(4-fluorophenyl)ethyl]piperidin-4-one Chemical compound N1([C@H](C)C=2C=CC(F)=CC=2)CCC(=O)CC1 JPLYVJGTOBCVEW-SNVBAGLBSA-N 0.000 description 2
- CDVAHHCNEWIUMV-LLVKDONJSA-N 1-[(1r)-1-phenylethyl]piperidin-4-one Chemical compound N1([C@H](C)C=2C=CC=CC=2)CCC(=O)CC1 CDVAHHCNEWIUMV-LLVKDONJSA-N 0.000 description 2
- QWKMIJLSWJYLDZ-AWEZNQCLSA-N 1-[(1s)-2,3-dihydro-1h-inden-1-yl]piperidin-4-one Chemical compound C1CC(=O)CCN1[C@@H]1C2=CC=CC=C2CC1 QWKMIJLSWJYLDZ-AWEZNQCLSA-N 0.000 description 2
- KFEWRNNUYYDFIO-UHFFFAOYSA-N 1-[(2-chlorophenyl)methyl]piperidin-4-one Chemical compound ClC1=CC=CC=C1CN1CCC(=O)CC1 KFEWRNNUYYDFIO-UHFFFAOYSA-N 0.000 description 2
- HRMRQBJUFWFQLX-UHFFFAOYSA-N 1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CCC(C(O)=O)C1 HRMRQBJUFWFQLX-UHFFFAOYSA-N 0.000 description 2
- LUIQWAIBTKXPNX-LURJTMIESA-N 1-[(2s)-1,1,1-trifluoropropan-2-yl]piperidin-4-one Chemical compound FC(F)(F)[C@H](C)N1CCC(=O)CC1 LUIQWAIBTKXPNX-LURJTMIESA-N 0.000 description 2
- XYIMUBJXPVXFMF-QMMMGPOBSA-N 1-[(2s)-butan-2-yl]piperidin-4-one Chemical compound CC[C@H](C)N1CCC(=O)CC1 XYIMUBJXPVXFMF-QMMMGPOBSA-N 0.000 description 2
- HEVYBHZSDSLRHX-UHFFFAOYSA-N 1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepane Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCNCCC2)CC1 HEVYBHZSDSLRHX-UHFFFAOYSA-N 0.000 description 2
- DRUQFFOVQXWCSK-UHFFFAOYSA-N 1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-4-(4-methylpyridin-2-yl)-1,4-diazepane Chemical compound CC1=CC=NC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=C1 DRUQFFOVQXWCSK-UHFFFAOYSA-N 0.000 description 2
- GUYOPNMJNVCHIO-UHFFFAOYSA-N 1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-4-(5-methylpyridin-2-yl)-1,4-diazepane Chemical compound N1=CC(C)=CC=C1N1CCN(C2CCN(CC=3C(=CC=CC=3)Cl)CC2)CCC1 GUYOPNMJNVCHIO-UHFFFAOYSA-N 0.000 description 2
- QUCPAIHGUSBGJA-UHFFFAOYSA-N 1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-4-(6-methylpyridin-2-yl)-1,4-diazepane Chemical compound CC1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 QUCPAIHGUSBGJA-UHFFFAOYSA-N 0.000 description 2
- MCTUAPVULTZQGY-UHFFFAOYSA-N 1-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-4-pyridin-2-yl-1,4-diazepane Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=CC=CC=2)CC1 MCTUAPVULTZQGY-UHFFFAOYSA-N 0.000 description 2
- FXGWDSZHKMXCMI-LJQANCHMSA-N 1-[1-[(2r)-butan-2-yl]piperidin-4-yl]-4-[6-(5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound C1CN([C@H](C)CC)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(CC)N=2)CCC1 FXGWDSZHKMXCMI-LJQANCHMSA-N 0.000 description 2
- SPMVMDHWKHCIDT-UHFFFAOYSA-N 1-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-3-(5-methyl-3-isoxazolyl)urea Chemical compound C=12C=C(OC)C(OC)=CC2=NC=CC=1OC(C=C1Cl)=CC=C1NC(=O)NC=1C=C(C)ON=1 SPMVMDHWKHCIDT-UHFFFAOYSA-N 0.000 description 2
- CKWMSUNKWAGMKC-UHFFFAOYSA-N 1-[6-(2-methyltetrazol-5-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C2=NN(C)N=N2)CCC1 CKWMSUNKWAGMKC-UHFFFAOYSA-N 0.000 description 2
- KJFJVIGDEMVWSA-UHFFFAOYSA-N 1-[6-(4,5-diethyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound N1C(CC)=C(CC)N=C1C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 KJFJVIGDEMVWSA-UHFFFAOYSA-N 0.000 description 2
- BDHKWHHBRXCYDL-UHFFFAOYSA-N 1-[6-(4,5-dimethyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC(C)=C(C)N=2)CCC1 BDHKWHHBRXCYDL-UHFFFAOYSA-N 0.000 description 2
- QGOKYFIRHYLROG-UHFFFAOYSA-N 1-[6-(4-cyclopropyl-5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound CCC=1NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=NC=1C1CC1 QGOKYFIRHYLROG-UHFFFAOYSA-N 0.000 description 2
- XZSQITPIQBDSHT-UHFFFAOYSA-N 1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC(C)=C(C3CC3)N=2)CCC1 XZSQITPIQBDSHT-UHFFFAOYSA-N 0.000 description 2
- UOVPLXDJOZJWOH-UHFFFAOYSA-N 1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(3-fluoro-1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound FC1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC(C)=C(C3CC3)N=2)CCC1 UOVPLXDJOZJWOH-UHFFFAOYSA-N 0.000 description 2
- TXMXQAURUXIBAR-UHFFFAOYSA-N 1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(3-fluoropiperidin-4-yl)-1,4-diazepane Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2CCN(CCC2)C2C(CNCC2)F)NC=1C1CC1 TXMXQAURUXIBAR-UHFFFAOYSA-N 0.000 description 2
- MMZPZQAFDOYGTE-UHFFFAOYSA-N 1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]piperazine Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2CCNCC2)NC=1C1CC1 MMZPZQAFDOYGTE-UHFFFAOYSA-N 0.000 description 2
- JNHUPAUQWMOZID-UHFFFAOYSA-N 1-[6-(4-ethyl-1-methylimidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound CCC1=CN(C)C(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 JNHUPAUQWMOZID-UHFFFAOYSA-N 0.000 description 2
- RLKBQQMIPWRSTN-UHFFFAOYSA-N 1-[6-(4-ethyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound CC1=C(CC)NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 RLKBQQMIPWRSTN-UHFFFAOYSA-N 0.000 description 2
- UHZQXDZDBIOACM-UHFFFAOYSA-N 1-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(3-fluoro-1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound FC1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(N=2)C2CC2)CCC1 UHZQXDZDBIOACM-UHFFFAOYSA-N 0.000 description 2
- OTJQGMCPANYDAC-UHFFFAOYSA-N 1-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(3-fluoropiperidin-4-yl)-1,4-diazepane Chemical compound FC1CNCCC1N1CCN(C=2N=C(C=CC=2)C=2NC(=CN=2)C2CC2)CCC1 OTJQGMCPANYDAC-UHFFFAOYSA-N 0.000 description 2
- ZNRYIRCBOYHEEC-UHFFFAOYSA-N 1-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(4-pyrrolidin-1-ylcyclohexyl)-1,4-diazepane Chemical compound C1CC1C1=CNC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCC(CC2)N2CCCC2)=N1 ZNRYIRCBOYHEEC-UHFFFAOYSA-N 0.000 description 2
- YWHRVTXFCNNDNO-UHFFFAOYSA-N 1-[6-(5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound CCC1=CNC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 YWHRVTXFCNNDNO-UHFFFAOYSA-N 0.000 description 2
- MVSBXDQYDPJDPF-KRWDZBQOSA-N 1-[6-(5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]-4-[1-[(2s)-1,1,1-trifluoropropan-2-yl]piperidin-4-yl]-1,4-diazepane Chemical compound CCC1=CNC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)[C@@H](C)C(F)(F)F)=N1 MVSBXDQYDPJDPF-KRWDZBQOSA-N 0.000 description 2
- BERIDYVWZNOICH-UHFFFAOYSA-N 1-[6-(5-methyl-4-propyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound N1C(C)=C(CCC)N=C1C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 BERIDYVWZNOICH-UHFFFAOYSA-N 0.000 description 2
- UOGCBLQZRLEIRW-UHFFFAOYSA-N 1-[6-(5-phenyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(N=2)C=2C=CC=CC=2)CCC1 UOGCBLQZRLEIRW-UHFFFAOYSA-N 0.000 description 2
- QIMNQLZLRWPCMR-UHFFFAOYSA-N 1-[6-(5-propan-2-yl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(N=2)C(C)C)CCC1 QIMNQLZLRWPCMR-UHFFFAOYSA-N 0.000 description 2
- RYAGFLBAVVAAER-UHFFFAOYSA-N 1-[6-(5-tert-butyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(N=2)C(C)(C)C)CCC1 RYAGFLBAVVAAER-UHFFFAOYSA-N 0.000 description 2
- CQRPLMGSGBYRHU-UHFFFAOYSA-N 1-[6-(5-tert-butyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-tert-butylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(N=2)C(C)(C)C)CCC1 CQRPLMGSGBYRHU-UHFFFAOYSA-N 0.000 description 2
- KIMKFSFLHPINST-UHFFFAOYSA-N 1-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]butan-1-one Chemical compound CCCC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 KIMKFSFLHPINST-UHFFFAOYSA-N 0.000 description 2
- FDROEKDATMXLMS-UHFFFAOYSA-N 1-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]propan-1-one Chemical compound CCC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 FDROEKDATMXLMS-UHFFFAOYSA-N 0.000 description 2
- SUHMUXANIRNCCH-UHFFFAOYSA-N 1-benzyl-3-methyl-1,4-diazepan-5-one Chemical compound C1CC(=O)NC(C)CN1CC1=CC=CC=C1 SUHMUXANIRNCCH-UHFFFAOYSA-N 0.000 description 2
- NGECKXKOOXAGCQ-UHFFFAOYSA-N 1-benzyl-3-methyl-1,4-diazepane Chemical compound C1CCNC(C)CN1CC1=CC=CC=C1 NGECKXKOOXAGCQ-UHFFFAOYSA-N 0.000 description 2
- NNTPEAXKKUPBHQ-UHFFFAOYSA-N 1-bromo-3-methylbutan-2-one Chemical compound CC(C)C(=O)CBr NNTPEAXKKUPBHQ-UHFFFAOYSA-N 0.000 description 2
- XNHTZBFSFZSWOO-UHFFFAOYSA-N 1-bromopentan-2-one Chemical compound CCCC(=O)CBr XNHTZBFSFZSWOO-UHFFFAOYSA-N 0.000 description 2
- XYIMUBJXPVXFMF-UHFFFAOYSA-N 1-butan-2-ylpiperidin-4-one Chemical compound CCC(C)N1CCC(=O)CC1 XYIMUBJXPVXFMF-UHFFFAOYSA-N 0.000 description 2
- VEXIBQGHRYNKAQ-UHFFFAOYSA-N 1-cyclopentyl-4-[4-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]piperazin-1-yl]azepane Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2CCN(CC2)C2CCN(CCC2)C2CCCC2)NC=1C1CC1 VEXIBQGHRYNKAQ-UHFFFAOYSA-N 0.000 description 2
- OJEDWBCGPOCKJW-UHFFFAOYSA-N 1-cyclopentylpiperidin-4-one Chemical compound C1CC(=O)CCN1C1CCCC1 OJEDWBCGPOCKJW-UHFFFAOYSA-N 0.000 description 2
- IRQOJWDMOUIHNR-UHFFFAOYSA-N 1-fluoropropan-2-amine Chemical compound CC(N)CF IRQOJWDMOUIHNR-UHFFFAOYSA-N 0.000 description 2
- PPMSCHPFBVKUCV-UHFFFAOYSA-N 1-methyl-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]benzimidazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2N(C3=CC=CC=C3N=2)C)CCC1 PPMSCHPFBVKUCV-UHFFFAOYSA-N 0.000 description 2
- YZRKDZPHDQJQJQ-UHFFFAOYSA-N 1-methyl-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]indole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2N(C3=CC=CC=C3C=2)C)CCC1 YZRKDZPHDQJQJQ-UHFFFAOYSA-N 0.000 description 2
- NUWRORAIHKGQGZ-UHFFFAOYSA-N 1-pentan-3-ylpiperidin-4-one Chemical compound CCC(CC)N1CCC(=O)CC1 NUWRORAIHKGQGZ-UHFFFAOYSA-N 0.000 description 2
- JVWOEUDGOQTPOE-UHFFFAOYSA-N 1-piperidin-4-yl-4-pyridin-2-yl-1,4-diazepane Chemical compound C1CNCCC1N1CCN(C=2N=CC=CC=2)CCC1 JVWOEUDGOQTPOE-UHFFFAOYSA-N 0.000 description 2
- XVKDTWAXFZTAKU-UHFFFAOYSA-N 1-propan-2-ylazepan-4-one Chemical compound CC(C)N1CCCC(=O)CC1 XVKDTWAXFZTAKU-UHFFFAOYSA-N 0.000 description 2
- YIVVBOYHOANILT-UHFFFAOYSA-N 1-pyridin-2-yl-1,4-diazepane Chemical compound C1CCNCCN1C1=CC=CC=N1 YIVVBOYHOANILT-UHFFFAOYSA-N 0.000 description 2
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 2
- HLIYECPSBGGOBN-UHFFFAOYSA-N 2,3-dihydroindol-1-yl-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]methanone Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)N2C3=CC=CC=C3CC2)CCC1 HLIYECPSBGGOBN-UHFFFAOYSA-N 0.000 description 2
- YFODOQRAEQFQHL-UHFFFAOYSA-N 2-(1,4-diazepan-1-yl)-1,3-thiazole Chemical compound C1CCNCCN1C1=NC=CS1 YFODOQRAEQFQHL-UHFFFAOYSA-N 0.000 description 2
- AMSYMXHFAAJGDP-UHFFFAOYSA-N 2-(6-chloropyridin-2-yl)-1-methylindole Chemical compound C=1C2=CC=CC=C2N(C)C=1C1=CC=CC(Cl)=N1 AMSYMXHFAAJGDP-UHFFFAOYSA-N 0.000 description 2
- BEAJSQTZNHTPEU-UHFFFAOYSA-N 2-(6-chloropyridin-2-yl)-3h-imidazo[4,5-c]pyridine Chemical compound ClC1=CC=CC(C=2NC3=CC=NC=C3N=2)=N1 BEAJSQTZNHTPEU-UHFFFAOYSA-N 0.000 description 2
- XCIJQGOMBGCEDC-UHFFFAOYSA-N 2-(dibenzylamino)cyclopentan-1-ol Chemical compound OC1CCCC1N(CC=1C=CC=CC=1)CC1=CC=CC=C1 XCIJQGOMBGCEDC-UHFFFAOYSA-N 0.000 description 2
- QQZOPKMRPOGIEB-UHFFFAOYSA-N 2-Oxohexane Chemical compound CCCCC(C)=O QQZOPKMRPOGIEB-UHFFFAOYSA-N 0.000 description 2
- BJKHSTDISPLINH-UHFFFAOYSA-N 2-[4-[1-(2,3-dihydro-1h-inden-1-yl)piperidin-4-yl]-1,4-diazepan-1-yl]-1,3-thiazole Chemical compound C1CC2=CC=CC=C2C1N(CC1)CCC1N(CC1)CCCN1C1=NC=CS1 BJKHSTDISPLINH-UHFFFAOYSA-N 0.000 description 2
- CRMVACNKGGRPCC-UHFFFAOYSA-N 2-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-1,3-thiazole Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2SC=CN=2)CC1 CRMVACNKGGRPCC-UHFFFAOYSA-N 0.000 description 2
- WOXFBRXGAYESEW-UHFFFAOYSA-N 2-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(3-imidazol-1-ylpropyl)-6-methylpyrimidine-4-carboxamide Chemical compound N=1C(C)=CC(C(=O)NCCCN2C=NC=C2)=NC=1N(CC1)CCCN1C(CC1)CCN1CC1=CC=CC=C1Cl WOXFBRXGAYESEW-UHFFFAOYSA-N 0.000 description 2
- YVSAQUNJJPRNTP-UHFFFAOYSA-N 2-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)-1,3-thiazole-4-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2SC=C(N=2)C(=O)NCC2CC2)CC1 YVSAQUNJJPRNTP-UHFFFAOYSA-N 0.000 description 2
- RMRZJNFFWPLVOQ-UHFFFAOYSA-N 2-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-4-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=CC=C(C=2)C(=O)NCC2CC2)CC1 RMRZJNFFWPLVOQ-UHFFFAOYSA-N 0.000 description 2
- CXWMSSAQYYNIGK-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,3-benzothiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2SC3=CC=CC=C3N=2)CCC1 CXWMSSAQYYNIGK-UHFFFAOYSA-N 0.000 description 2
- WPMUJFLBJHIDSS-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,3-benzoxazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2OC3=CC=CC=C3N=2)CCC1 WPMUJFLBJHIDSS-UHFFFAOYSA-N 0.000 description 2
- HGVGOXXITQWWIS-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-benzimidazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC=CC=C3N=2)CCC1 HGVGOXXITQWWIS-UHFFFAOYSA-N 0.000 description 2
- RVQMERHJAQLJBF-UHFFFAOYSA-N 2-bromo-1-cyclopropylbutan-1-one Chemical compound CCC(Br)C(=O)C1CC1 RVQMERHJAQLJBF-UHFFFAOYSA-N 0.000 description 2
- WCCCDMWRBVVYCQ-UHFFFAOYSA-N 2-bromo-1-cyclopropylethanone Chemical compound BrCC(=O)C1CC1 WCCCDMWRBVVYCQ-UHFFFAOYSA-N 0.000 description 2
- NPNNSQQYZVWPMG-UHFFFAOYSA-N 2-bromo-1-cyclopropylpropan-1-one Chemical compound CC(Br)C(=O)C1CC1 NPNNSQQYZVWPMG-UHFFFAOYSA-N 0.000 description 2
- KLIVZXUDEQOARM-UHFFFAOYSA-N 2-bromo-n-(cyclopropylmethyl)-1,3-thiazole-4-carboxamide Chemical compound S1C(Br)=NC(C(=O)NCC2CC2)=C1 KLIVZXUDEQOARM-UHFFFAOYSA-N 0.000 description 2
- OILFHRAEQCQPFY-UHFFFAOYSA-N 2-chloro-6-(4,5-diethyl-1h-imidazol-2-yl)pyridine Chemical compound N1C(CC)=C(CC)N=C1C1=CC=CC(Cl)=N1 OILFHRAEQCQPFY-UHFFFAOYSA-N 0.000 description 2
- YOAWWTAWYJGKAT-UHFFFAOYSA-N 2-chloro-6-(5-methyl-1h-imidazol-2-yl)pyridine Chemical compound N1C(C)=CN=C1C1=CC=CC(Cl)=N1 YOAWWTAWYJGKAT-UHFFFAOYSA-N 0.000 description 2
- ABJJCTUQCPGBDT-UHFFFAOYSA-N 2-chloro-n-(3-imidazol-1-ylpropyl)-6-methylpyrimidine-4-carboxamide Chemical compound ClC1=NC(C)=CC(C(=O)NCCCN2C=NC=C2)=N1 ABJJCTUQCPGBDT-UHFFFAOYSA-N 0.000 description 2
- PWTNHIVZYHGFRQ-UHFFFAOYSA-N 2-chloro-n-(cyclopropylmethyl)pyridine-4-carboxamide Chemical compound C1=NC(Cl)=CC(C(=O)NCC2CC2)=C1 PWTNHIVZYHGFRQ-UHFFFAOYSA-N 0.000 description 2
- 150000005759 2-chloropyridine Chemical class 0.000 description 2
- JQWJRZINMMEFND-UHFFFAOYSA-N 2-cyclopropyl-5-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,3,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2OC(=NN=2)C2CC2)CCC1 JQWJRZINMMEFND-UHFFFAOYSA-N 0.000 description 2
- SYDPJQJXMGPZQF-UHFFFAOYSA-N 2-fluorocyclopentan-1-amine Chemical compound NC1CCCC1F SYDPJQJXMGPZQF-UHFFFAOYSA-N 0.000 description 2
- LBAKOCZGMFOEHV-UHFFFAOYSA-N 2-methyl-1-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1C(C)CNCCC1 LBAKOCZGMFOEHV-UHFFFAOYSA-N 0.000 description 2
- KCJWZUWUQKEYFM-UHFFFAOYSA-N 2-phenyl-1-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]ethanone Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)CC=2C=CC=CC=2)CCC1 KCJWZUWUQKEYFM-UHFFFAOYSA-N 0.000 description 2
- VHMICKWLTGFITH-UHFFFAOYSA-N 2H-isoindole Chemical compound C1=CC=CC2=CNC=C21 VHMICKWLTGFITH-UHFFFAOYSA-N 0.000 description 2
- WSKPUJRCGIQAIL-UHFFFAOYSA-N 3,4-dihydro-1h-isoquinolin-2-yl-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]methanone Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)N2CC3=CC=CC=C3CC2)CCC1 WSKPUJRCGIQAIL-UHFFFAOYSA-N 0.000 description 2
- HGPGARPFJDQSAN-UHFFFAOYSA-N 3-(3,3-difluoropyrrolidin-1-yl)propyl methanesulfonate Chemical compound CS(=O)(=O)OCCCN1CCC(F)(F)C1 HGPGARPFJDQSAN-UHFFFAOYSA-N 0.000 description 2
- RKMOFICPWBTLEB-UHFFFAOYSA-N 3-(3,4-dihydro-1h-isoquinolin-2-yl)propyl methanesulfonate Chemical compound C1=CC=C2CN(CCCOS(=O)(=O)C)CCC2=C1 RKMOFICPWBTLEB-UHFFFAOYSA-N 0.000 description 2
- BYHQTRFJOGIQAO-GOSISDBHSA-N 3-(4-bromophenyl)-8-[(2R)-2-hydroxypropyl]-1-[(3-methoxyphenyl)methyl]-1,3,8-triazaspiro[4.5]decan-2-one Chemical compound C[C@H](CN1CCC2(CC1)CN(C(=O)N2CC3=CC(=CC=C3)OC)C4=CC=C(C=C4)Br)O BYHQTRFJOGIQAO-GOSISDBHSA-N 0.000 description 2
- YGYGASJNJTYNOL-CQSZACIVSA-N 3-[(4r)-2,2-dimethyl-1,1-dioxothian-4-yl]-5-(4-fluorophenyl)-1h-indole-7-carboxamide Chemical compound C1CS(=O)(=O)C(C)(C)C[C@@H]1C1=CNC2=C(C(N)=O)C=C(C=3C=CC(F)=CC=3)C=C12 YGYGASJNJTYNOL-CQSZACIVSA-N 0.000 description 2
- WLUFTOCGVOCYLK-UHFFFAOYSA-N 3-[2-(1,4-diazepan-1-yl)ethyl]-4-propan-2-ylmorpholine Chemical compound CC(C)N1CCOCC1CCN1CCNCCC1 WLUFTOCGVOCYLK-UHFFFAOYSA-N 0.000 description 2
- CXMBDTFSHKFCKZ-UHFFFAOYSA-N 3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-5-propyl-1,2,4-oxadiazole Chemical compound O1C(CCC)=NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 CXMBDTFSHKFCKZ-UHFFFAOYSA-N 0.000 description 2
- CCDOLFXNYDONFE-LJQANCHMSA-N 3-[6-[4-[1-[(2r)-butan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridin-2-yl]-5-propyl-1,2,4-oxadiazole Chemical compound O1C(CCC)=NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)[C@H](C)CC)=N1 CCDOLFXNYDONFE-LJQANCHMSA-N 0.000 description 2
- JVKNKFDGLBRQPB-UHFFFAOYSA-N 3-benzyl-3,6-diazabicyclo[3.2.2]nonane Chemical compound C1C(CN2)CCC2CN1CC1=CC=CC=C1 JVKNKFDGLBRQPB-UHFFFAOYSA-N 0.000 description 2
- LLJAQCFUNJCQNH-UHFFFAOYSA-N 3-benzyl-6-(3-fluoro-1-propan-2-ylpiperidin-4-yl)-3,6-diazabicyclo[3.2.2]nonane Chemical compound FC1CN(C(C)C)CCC1N1C(CN(CC=2C=CC=CC=2)C2)CCC2C1 LLJAQCFUNJCQNH-UHFFFAOYSA-N 0.000 description 2
- VKJQRFXZZVMMGA-UHFFFAOYSA-N 3-bromopentan-2-one Chemical compound CCC(Br)C(C)=O VKJQRFXZZVMMGA-UHFFFAOYSA-N 0.000 description 2
- SQAZNGDXQNMSHT-UHFFFAOYSA-N 3-cyclopropyl-5-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2ON=C(N=2)C2CC2)CCC1 SQAZNGDXQNMSHT-UHFFFAOYSA-N 0.000 description 2
- KXXZJZVLUDIVAW-UHFFFAOYSA-N 3-iodohexan-2-one Chemical compound CCCC(I)C(C)=O KXXZJZVLUDIVAW-UHFFFAOYSA-N 0.000 description 2
- ZFAWQMZAMGNFKW-UHFFFAOYSA-N 3-phenyl-5-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2ON=C(N=2)C=2C=CC=CC=2)CCC1 ZFAWQMZAMGNFKW-UHFFFAOYSA-N 0.000 description 2
- HKEQNJJYWZWKMC-UHFFFAOYSA-N 4,4,4-trifluorobutan-2-amine Chemical compound CC(N)CC(F)(F)F HKEQNJJYWZWKMC-UHFFFAOYSA-N 0.000 description 2
- XXJWYDDUDKYVKI-UHFFFAOYSA-N 4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline Chemical compound COC1=CC2=C(OC=3C(=C4C=C(C)NC4=CC=3)F)N=CN=C2C=C1OCCCN1CCCC1 XXJWYDDUDKYVKI-UHFFFAOYSA-N 0.000 description 2
- ZLKUEXXAPJUZEX-UHFFFAOYSA-N 4-[4-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]piperazin-1-yl]-1-propan-2-ylazepane Chemical compound C1CN(C(C)C)CCCC1N1CCN(C=2N=C(C=CC=2)C=2NC(=C(C)N=2)C2CC2)CC1 ZLKUEXXAPJUZEX-UHFFFAOYSA-N 0.000 description 2
- XYWIPYBIIRTJMM-IBGZPJMESA-N 4-[[(2S)-2-[4-[5-chloro-2-[4-(trifluoromethyl)triazol-1-yl]phenyl]-5-methoxy-2-oxopyridin-1-yl]butanoyl]amino]-2-fluorobenzamide Chemical compound CC[C@H](N1C=C(OC)C(=CC1=O)C1=C(C=CC(Cl)=C1)N1C=C(N=N1)C(F)(F)F)C(=O)NC1=CC(F)=C(C=C1)C(N)=O XYWIPYBIIRTJMM-IBGZPJMESA-N 0.000 description 2
- QFCXANHHBCGMAS-UHFFFAOYSA-N 4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-n-methylpyridine-2-carboxamide Chemical compound C1=NC(C(=O)NC)=CC(COC=2C=3OC=CC=3C(NC=3C=CC(Cl)=CC=3)=NN=2)=C1 QFCXANHHBCGMAS-UHFFFAOYSA-N 0.000 description 2
- GKWVJBPZZHVZND-UHFFFAOYSA-N 4-fluoro-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-benzimidazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=C(F)C=CC=C3N=2)CCC1 GKWVJBPZZHVZND-UHFFFAOYSA-N 0.000 description 2
- XTEOXRCHHWCHJB-UHFFFAOYSA-N 4-methyl-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-benzimidazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=C(C)C=CC=C3N=2)CCC1 XTEOXRCHHWCHJB-UHFFFAOYSA-N 0.000 description 2
- DMPLJICYJKFHSR-UHFFFAOYSA-N 5,6-difluoro-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-benzimidazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC(F)=C(F)C=C3N=2)CCC1 DMPLJICYJKFHSR-UHFFFAOYSA-N 0.000 description 2
- PWAUFCYRBTZWIF-UHFFFAOYSA-N 5-(2,2-dimethylpropyl)-3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2N=C(CC(C)(C)C)ON=2)CCC1 PWAUFCYRBTZWIF-UHFFFAOYSA-N 0.000 description 2
- ZIBQDBWBEQVWKN-UHFFFAOYSA-N 5-butyl-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,3-oxazole Chemical compound O1C(CCCC)=CN=C1C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 ZIBQDBWBEQVWKN-UHFFFAOYSA-N 0.000 description 2
- OHXOJVTYUUNFOZ-UHFFFAOYSA-N 5-butyl-3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound O1C(CCCC)=NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 OHXOJVTYUUNFOZ-UHFFFAOYSA-N 0.000 description 2
- DPHDMIPLUBDPDJ-UHFFFAOYSA-N 5-cyclopropyl-3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2N=C(ON=2)C2CC2)CCC1 DPHDMIPLUBDPDJ-UHFFFAOYSA-N 0.000 description 2
- ASSABDGNLUSXGW-UHFFFAOYSA-N 5-methyl-3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2N=C(C)ON=2)CCC1 ASSABDGNLUSXGW-UHFFFAOYSA-N 0.000 description 2
- SVOOSIXXZWNOIT-UHFFFAOYSA-N 5-phenyl-3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2N=C(ON=2)C=2C=CC=CC=2)CCC1 SVOOSIXXZWNOIT-UHFFFAOYSA-N 0.000 description 2
- HXGFEWMHNDAWAT-UHFFFAOYSA-N 5-tert-butyl-3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1,2,4-oxadiazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2N=C(ON=2)C(C)(C)C)CCC1 HXGFEWMHNDAWAT-UHFFFAOYSA-N 0.000 description 2
- YGWPBNAUIIBLND-UHFFFAOYSA-N 6-(1-benzylpiperidin-4-yl)oxy-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(OC2CCN(CC=3C=CC=CC=3)CC2)=NC=1C(=O)NC1=CC=NC=C1 YGWPBNAUIIBLND-UHFFFAOYSA-N 0.000 description 2
- PVUYANWNYRUUJE-UHFFFAOYSA-N 6-(1-benzylpiperidin-4-yl)oxypyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(OC2CCN(CC=3C=CC=CC=3)CC2)=N1 PVUYANWNYRUUJE-UHFFFAOYSA-N 0.000 description 2
- SXBZZQZPCLYICD-UHFFFAOYSA-N 6-(1-propan-2-ylpiperidin-4-yl)-3,6-diazabicyclo[3.2.2]nonane Chemical compound C1CN(C(C)C)CCC1N1C(CNC2)CCC2C1 SXBZZQZPCLYICD-UHFFFAOYSA-N 0.000 description 2
- PQASZQNXMZJTCM-UHFFFAOYSA-N 6-(3-fluoro-1-propan-2-ylpiperidin-4-yl)-3,6-diazabicyclo[3.2.2]nonane Chemical compound FC1CN(C(C)C)CCC1N1C(CNC2)CCC2C1 PQASZQNXMZJTCM-UHFFFAOYSA-N 0.000 description 2
- AJSBMJMEFKWOBZ-UHFFFAOYSA-N 6-(4-aminopiperidin-1-yl)-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound C1CC(N)CCN1C1=CC=CC(C(=O)NCC2CC2)=N1 AJSBMJMEFKWOBZ-UHFFFAOYSA-N 0.000 description 2
- HGZQRVPVVZTAJA-UHFFFAOYSA-N 6-(6-methyl-1,4-diazepan-1-yl)-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1C(C)CNCCN1C1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 HGZQRVPVVZTAJA-UHFFFAOYSA-N 0.000 description 2
- SFYINOLFCRZLMJ-UHFFFAOYSA-N 6-(6-piperidin-4-yl-3,6-diazabicyclo[3.2.2]nonan-3-yl)-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2CC3CCC(CN3C3CCNCC3)C2)=NC=1C(=O)NC1=CC=NC=C1 SFYINOLFCRZLMJ-UHFFFAOYSA-N 0.000 description 2
- ZFGYIURTOGLFJL-TZIWHRDSSA-N 6-[(3r)-3-[[(3r)-1-cyclopentylpyrrolidin-3-yl]methylamino]pyrrolidin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2C[C@@H](CC2)NC[C@@H]2CN(CC2)C2CCCC2)=NC=1C(=O)NC1=CC=NC=C1 ZFGYIURTOGLFJL-TZIWHRDSSA-N 0.000 description 2
- ZFGYIURTOGLFJL-PZJWPPBQSA-N 6-[(3r)-3-[[(3s)-1-cyclopentylpyrrolidin-3-yl]methylamino]pyrrolidin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2C[C@@H](CC2)NC[C@H]2CN(CC2)C2CCCC2)=NC=1C(=O)NC1=CC=NC=C1 ZFGYIURTOGLFJL-PZJWPPBQSA-N 0.000 description 2
- OETDYOKBGQEJTD-LLVKDONJSA-N 6-[(3r)-3-aminopyrrolidin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1[C@H](N)CCN1C1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 OETDYOKBGQEJTD-LLVKDONJSA-N 0.000 description 2
- HFRVWBGYTQHFLE-UHFFFAOYSA-N 6-[1-(1-propan-2-ylazepan-4-yl)piperidin-4-yl]oxy-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCCC1N1CCC(OC=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CC1 HFRVWBGYTQHFLE-UHFFFAOYSA-N 0.000 description 2
- LKWFZVDCICYEAZ-UHFFFAOYSA-N 6-[1-(azepan-4-yl)piperidin-4-yl]oxy-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(OC2CCN(CC2)C2CCNCCC2)=NC=1C(=O)NC1=CC=NC=C1 LKWFZVDCICYEAZ-UHFFFAOYSA-N 0.000 description 2
- CJLXOVFEEJIYQZ-UHFFFAOYSA-N 6-[10-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-4,10-diazabicyclo[4.3.1]decan-4-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2C3CCCC2CCN(C3)C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CC1 CJLXOVFEEJIYQZ-UHFFFAOYSA-N 0.000 description 2
- BRIAMUHVIWOGTF-UHFFFAOYSA-N 6-[3-methyl-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1C(C)CN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 BRIAMUHVIWOGTF-UHFFFAOYSA-N 0.000 description 2
- IFQJUQSMHMAQDY-UHFFFAOYSA-N 6-[4-(1-benzylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCN(CC=3C=CC=CC=3)CC2)=NC=1C(=O)NCC1CC1 IFQJUQSMHMAQDY-UHFFFAOYSA-N 0.000 description 2
- XYZVHDNXHPZFEL-UHFFFAOYSA-N 6-[4-(1-butan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound C1CN(C(C)CC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 XYZVHDNXHPZFEL-UHFFFAOYSA-N 0.000 description 2
- SDSNIFIRRPBMDV-UHFFFAOYSA-N 6-[4-(1-cyclopentylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCN(CC2)C2CCCC2)=NC=1C(=O)NCC1CC1 SDSNIFIRRPBMDV-UHFFFAOYSA-N 0.000 description 2
- PJIDOYNGVYOOIW-UHFFFAOYSA-N 6-[4-(1-cyclopentylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCN(CC2)C2CCCC2)=NC=1C(=O)NC1=CC=NC=C1 PJIDOYNGVYOOIW-UHFFFAOYSA-N 0.000 description 2
- KPKTXBJQZMKVNQ-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(1,3-thiazol-2-yl)pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2SC=CN=2)CCC1 KPKTXBJQZMKVNQ-UHFFFAOYSA-N 0.000 description 2
- VKDUFSABEYPGCT-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(1,3-thiazol-4-ylmethyl)pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2N=CSC=2)CCC1 VKDUFSABEYPGCT-UHFFFAOYSA-N 0.000 description 2
- UALZJRLGMOGNEH-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(1,3-thiazol-5-yl)pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2SC=NC=2)CCC1 UALZJRLGMOGNEH-UHFFFAOYSA-N 0.000 description 2
- GVXQVVJQAAALMX-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(2-pyridin-2-ylethyl)pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCCC=2N=CC=CC=2)CCC1 GVXQVVJQAAALMX-UHFFFAOYSA-N 0.000 description 2
- RATCSPXHSJQNTO-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(pyridin-2-ylmethyl)pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2N=CC=CC=2)CCC1 RATCSPXHSJQNTO-UHFFFAOYSA-N 0.000 description 2
- LTOBUZUANRGSEZ-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(pyridin-4-ylmethyl)pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=CN=CC=2)CCC1 LTOBUZUANRGSEZ-UHFFFAOYSA-N 0.000 description 2
- OMGPXNAIRVGIBF-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-propylpyridine-2-carboxamide Chemical compound CCCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 OMGPXNAIRVGIBF-UHFFFAOYSA-N 0.000 description 2
- ZCGXELKCFPBBLS-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-2-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2N=CC=CC=2)CCC1 ZCGXELKCFPBBLS-UHFFFAOYSA-N 0.000 description 2
- SLXKBXWHJJPMJI-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-3-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=NC=CC=2)CCC1 SLXKBXWHJJPMJI-UHFFFAOYSA-N 0.000 description 2
- KUWCNTBFSAGHDZ-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carbohydrazide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NN)CCC1 KUWCNTBFSAGHDZ-UHFFFAOYSA-N 0.000 description 2
- NUXHUDLCXZOXTH-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxylic acid Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(O)=O)CCC1 NUXHUDLCXZOXTH-UHFFFAOYSA-N 0.000 description 2
- AUIFTFPZVWGYMI-UHFFFAOYSA-N 6-[4-(1-tert-butylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound C1CN(C(C)(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 AUIFTFPZVWGYMI-UHFFFAOYSA-N 0.000 description 2
- QYRRVNYAYHQVDM-UHFFFAOYSA-N 6-[4-(1-tert-butylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 QYRRVNYAYHQVDM-UHFFFAOYSA-N 0.000 description 2
- SWBIVCDTCSCIRE-UHFFFAOYSA-N 6-[4-(2-methyl-1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound C1C(C)N(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CCC1 SWBIVCDTCSCIRE-UHFFFAOYSA-N 0.000 description 2
- DRGFRTZEOIJYMT-UHFFFAOYSA-N 6-[4-(2-methylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound C1CNC(C)CC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CCC1 DRGFRTZEOIJYMT-UHFFFAOYSA-N 0.000 description 2
- NLIKJBUSWVWYDT-UHFFFAOYSA-N 6-[4-(3-chloro-2-hydroxypropyl)-1,4-diazepan-1-yl]-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound C1CN(CC(CCl)O)CCCN1C1=CC=CC(C(=O)NCC=2C=NC=CC=2)=N1 NLIKJBUSWVWYDT-UHFFFAOYSA-N 0.000 description 2
- WTEAYVHVICAIEE-UHFFFAOYSA-N 6-[4-(3-fluoro-1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound FC1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 WTEAYVHVICAIEE-UHFFFAOYSA-N 0.000 description 2
- ZTGSYSRKOAXVIX-UHFFFAOYSA-N 6-[4-(3-fluoropiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound FC1CNCCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 ZTGSYSRKOAXVIX-UHFFFAOYSA-N 0.000 description 2
- WIAOVWFZTPGGEI-UHFFFAOYSA-N 6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound C1CC(C(C)(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CCC1 WIAOVWFZTPGGEI-UHFFFAOYSA-N 0.000 description 2
- HQLXGOJRLBRPSK-UHFFFAOYSA-N 6-[4-(4-tert-butylcyclohexyl)-1,4-diazepan-1-yl]pyridine-2-carboxylic acid Chemical compound C1CC(C(C)(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(O)=O)CCC1 HQLXGOJRLBRPSK-UHFFFAOYSA-N 0.000 description 2
- GPSGKVJMZMOJJM-UHFFFAOYSA-N 6-[4-[(2-chloro-4-fluorophenyl)methyl]-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound ClC1=CC(F)=CC=C1CN1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 GPSGKVJMZMOJJM-UHFFFAOYSA-N 0.000 description 2
- QWEXKLXRJYUWOV-WOJBJXKFSA-N 6-[4-[(3r,4r)-3-hydroxypiperidin-4-yl]-1,4-diazepan-1-yl]-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound O[C@@H]1CNCC[C@H]1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CCC1 QWEXKLXRJYUWOV-WOJBJXKFSA-N 0.000 description 2
- PGFJNUHUAQGXBU-UHFFFAOYSA-N 6-[4-[1-[(2-chloro-4-fluorophenyl)methyl]azepan-4-yl]piperazin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC(N2CCN(CC2)C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 PGFJNUHUAQGXBU-UHFFFAOYSA-N 0.000 description 2
- WNKNQSCEUFVRIT-UHFFFAOYSA-N 6-[4-[1-[(2-chloro-4-fluorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC(F)=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CC2)CC1 WNKNQSCEUFVRIT-UHFFFAOYSA-N 0.000 description 2
- XUVVELOOVSMFDE-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(2,2,2-trifluoroethyl)pyridine-2-carboxamide Chemical compound FC(F)(F)CNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 XUVVELOOVSMFDE-UHFFFAOYSA-N 0.000 description 2
- QIJMAEYJLKGTNS-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(2,6-dimethylpyridin-4-yl)pyridine-2-carboxamide Chemical compound CC1=NC(C)=CC(NC(=O)C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=C1 QIJMAEYJLKGTNS-UHFFFAOYSA-N 0.000 description 2
- MHEPYCPJHMSOSL-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(2-methoxyethyl)pyridine-2-carboxamide Chemical compound COCCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 MHEPYCPJHMSOSL-UHFFFAOYSA-N 0.000 description 2
- QDFDWYGXMAMJPM-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(2-methylpyridin-4-yl)pyridine-2-carboxamide Chemical compound C1=NC(C)=CC(NC(=O)C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=C1 QDFDWYGXMAMJPM-UHFFFAOYSA-N 0.000 description 2
- AYJUZJOSIMUCDD-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(3-imidazol-1-ylpropyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCCCN2C=NC=C2)CC1 AYJUZJOSIMUCDD-UHFFFAOYSA-N 0.000 description 2
- FHUJQPJAGZJSQH-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(3-methylbutyl)pyridine-2-carboxamide Chemical compound CC(C)CCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 FHUJQPJAGZJSQH-UHFFFAOYSA-N 0.000 description 2
- OHZHMJSVHZQQAF-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)-4-methylpyridine-2-carboxamide Chemical compound C=1C(C)=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=NC=1C(=O)NCC1CC1 OHZHMJSVHZQQAF-UHFFFAOYSA-N 0.000 description 2
- QJVGPWYHAMAJLN-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)-5-methoxypyridine-2-carboxamide Chemical compound COC1=CC=C(C(=O)NCC2CC2)N=C1N(CC1)CCCN1C(CC1)CCN1CC1=CC=CC=C1Cl QJVGPWYHAMAJLN-UHFFFAOYSA-N 0.000 description 2
- CVPQHEOLCSYAIH-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CC2)CC1 CVPQHEOLCSYAIH-UHFFFAOYSA-N 0.000 description 2
- FOFBIZCIAKBAFU-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(oxan-4-yl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NC2CCOCC2)CC1 FOFBIZCIAKBAFU-UHFFFAOYSA-N 0.000 description 2
- QANGZSQBJRVOCB-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(oxan-4-ylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CCOCC2)CC1 QANGZSQBJRVOCB-UHFFFAOYSA-N 0.000 description 2
- LCBFYYNDRCMLNZ-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CC1 LCBFYYNDRCMLNZ-UHFFFAOYSA-N 0.000 description 2
- GRRKCCLKCKFWKN-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(pyridin-4-ylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC=2C=CN=CC=2)CC1 GRRKCCLKCKFWKN-UHFFFAOYSA-N 0.000 description 2
- SIYVAAXUIZBWGZ-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-ethylpyridine-2-carboxamide Chemical compound CCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 SIYVAAXUIZBWGZ-UHFFFAOYSA-N 0.000 description 2
- QZKSGLWOOAMJLA-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CC1 QZKSGLWOOAMJLA-UHFFFAOYSA-N 0.000 description 2
- SMEXXYBDDXFPKI-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carbonitrile Chemical compound ClC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C#N)CC1 SMEXXYBDDXFPKI-UHFFFAOYSA-N 0.000 description 2
- JHRKIDPSDKPQOD-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound NC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 JHRKIDPSDKPQOD-UHFFFAOYSA-N 0.000 description 2
- RXLZBDMMONECFO-UHFFFAOYSA-N 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 RXLZBDMMONECFO-UHFFFAOYSA-N 0.000 description 2
- UVBMWQQVZGDFCR-UHFFFAOYSA-N 6-[4-[1-[(2-methylphenyl)methyl]azepan-4-yl]piperazin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound CC1=CC=CC=C1CN1CCC(N2CCN(CC2)C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 UVBMWQQVZGDFCR-UHFFFAOYSA-N 0.000 description 2
- XDLFGYFJWAMRJF-HXUWFJFHSA-N 6-[4-[1-[(2r)-butan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN([C@H](C)CC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 XDLFGYFJWAMRJF-HXUWFJFHSA-N 0.000 description 2
- XDLFGYFJWAMRJF-FQEVSTJZSA-N 6-[4-[1-[(2s)-butan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN([C@@H](C)CC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 XDLFGYFJWAMRJF-FQEVSTJZSA-N 0.000 description 2
- ARYKYCQMTWQKQU-UHFFFAOYSA-N 6-[4-[1-[(3-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC(CN2CCC(CC2)N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CC2)=C1 ARYKYCQMTWQKQU-UHFFFAOYSA-N 0.000 description 2
- GSKLVKOTVICTQP-UHFFFAOYSA-N 6-[4-[2-hydroxy-3-(propan-2-ylamino)propyl]-1,4-diazepan-1-yl]-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound C1CN(CC(O)CNC(C)C)CCCN1C1=CC=CC(C(=O)NCC=2C=NC=CC=2)=N1 GSKLVKOTVICTQP-UHFFFAOYSA-N 0.000 description 2
- ZBWJOFZKUQXAQP-UHFFFAOYSA-N 6-[4-[3-[(2-chlorophenyl)methylamino]propyl]-1,4-diazepan-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CNCCCN1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 ZBWJOFZKUQXAQP-UHFFFAOYSA-N 0.000 description 2
- KHBIRAIVWGFRJN-UHFFFAOYSA-N 6-[6-(1-propan-2-ylpiperidin-4-yl)-3,6-diazabicyclo[3.2.2]nonan-3-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1C(CN(C2)C=3N=C(C=CC=3)C(=O)NC=3C=CN=CC=3)CCC2C1 KHBIRAIVWGFRJN-UHFFFAOYSA-N 0.000 description 2
- BUDTZBNDHIRZGM-UHFFFAOYSA-N 6-[6-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-3,6-diazabicyclo[3.2.2]nonan-3-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CN1CCC(N2C3CCC(CN(C3)C=3N=C(C=CC=3)C(=O)NC=3C=CN=CC=3)C2)CC1 BUDTZBNDHIRZGM-UHFFFAOYSA-N 0.000 description 2
- YTWOPTBPFDXISQ-UHFFFAOYSA-N 6-[6-methyl-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CC(C)CN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CC1 YTWOPTBPFDXISQ-UHFFFAOYSA-N 0.000 description 2
- RRXDWSZOLJGIMG-UHFFFAOYSA-N 6-[methyl-[2-(methylamino)ethyl]amino]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound CNCCN(C)C1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 RRXDWSZOLJGIMG-UHFFFAOYSA-N 0.000 description 2
- FJCSTMPVEWKZFN-UHFFFAOYSA-N 6-[methyl-[2-[methyl-(1-propan-2-ylazepan-4-yl)amino]ethyl]amino]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCCC1N(C)CCN(C)C1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 FJCSTMPVEWKZFN-UHFFFAOYSA-N 0.000 description 2
- VZOKXZRWMRKIAH-UHFFFAOYSA-N 6-bromo-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound BrC1=CC=CC(C(=O)NCC2CC2)=N1 VZOKXZRWMRKIAH-UHFFFAOYSA-N 0.000 description 2
- DHBDVQYYCDSOHY-UHFFFAOYSA-N 6-bromo-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound BrC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 DHBDVQYYCDSOHY-UHFFFAOYSA-N 0.000 description 2
- YAAVBEFHGNXNMS-UHFFFAOYSA-N 6-chloro-n-(3-imidazol-1-ylpropyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC(C(=O)NCCCN2C=NC=C2)=N1 YAAVBEFHGNXNMS-UHFFFAOYSA-N 0.000 description 2
- HOQJVZVTXKBRMC-UHFFFAOYSA-N 6-chloro-n-(4-oxohexan-3-yl)pyridine-2-carboxamide Chemical compound CCC(=O)C(CC)NC(=O)C1=CC=CC(Cl)=N1 HOQJVZVTXKBRMC-UHFFFAOYSA-N 0.000 description 2
- MGCZSPUKLCJAJG-UHFFFAOYSA-N 6-chloro-n-(cyclopropylmethyl)-3-methylpyridine-2-carboxamide Chemical compound CC1=CC=C(Cl)N=C1C(=O)NCC1CC1 MGCZSPUKLCJAJG-UHFFFAOYSA-N 0.000 description 2
- DBNFRAVWFDSASG-UHFFFAOYSA-N 6-chloro-n-(cyclopropylmethyl)-4-methylpyridine-2-carboxamide Chemical compound CC1=CC(Cl)=NC(C(=O)NCC2CC2)=C1 DBNFRAVWFDSASG-UHFFFAOYSA-N 0.000 description 2
- GJZOIARCFCZUMJ-UHFFFAOYSA-N 6-chloro-n-(cyclopropylmethyl)-5-methoxypyridine-2-carboxamide Chemical compound N1=C(Cl)C(OC)=CC=C1C(=O)NCC1CC1 GJZOIARCFCZUMJ-UHFFFAOYSA-N 0.000 description 2
- RFLBQSUYIQMXSF-UHFFFAOYSA-N 6-chloro-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC(C(=O)NCC2CC2)=N1 RFLBQSUYIQMXSF-UHFFFAOYSA-N 0.000 description 2
- OYNOGWLQIBQBLP-UHFFFAOYSA-N 6-chloro-n-ethylpyridine-2-carboxamide Chemical compound CCNC(=O)C1=CC=CC(Cl)=N1 OYNOGWLQIBQBLP-UHFFFAOYSA-N 0.000 description 2
- WNGXKXSOYJGNMC-UHFFFAOYSA-N 6-fluoro-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-benzimidazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC(F)=CC=C3N=2)CCC1 WNGXKXSOYJGNMC-UHFFFAOYSA-N 0.000 description 2
- KXDRXNZOOOKAEI-UHFFFAOYSA-N 6-methoxy-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-benzimidazole Chemical compound N1C2=CC(OC)=CC=C2N=C1C(N=1)=CC=CC=1N(CC1)CCCN1C1CCN(C(C)C)CC1 KXDRXNZOOOKAEI-UHFFFAOYSA-N 0.000 description 2
- JMVNLDIFYOVCPI-UHFFFAOYSA-N 6-methyl-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-benzimidazole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC(C)=CC=C3N=2)CCC1 JMVNLDIFYOVCPI-UHFFFAOYSA-N 0.000 description 2
- XKCZAEJIKWQMFA-UHFFFAOYSA-N 6-piperazin-1-yl-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2CCNCC2)=NC=1C(=O)NC1=CC=NC=C1 XKCZAEJIKWQMFA-UHFFFAOYSA-N 0.000 description 2
- AMABRVXVRGFTGW-UHFFFAOYSA-N 6-piperidin-4-yloxy-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(OC2CCNCC2)=NC=1C(=O)NC1=CC=NC=C1 AMABRVXVRGFTGW-UHFFFAOYSA-N 0.000 description 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 2
- ZRPZPNYZFSJUPA-UHFFFAOYSA-N ARS-1620 Chemical compound Oc1cccc(F)c1-c1c(Cl)cc2c(ncnc2c1F)N1CCN(CC1)C(=O)C=C ZRPZPNYZFSJUPA-UHFFFAOYSA-N 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 description 2
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 description 2
- 102100026189 Beta-galactosidase Human genes 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 2
- 238000006443 Buchwald-Hartwig cross coupling reaction Methods 0.000 description 2
- WROYMNFAZWHLSZ-UHFFFAOYSA-N CC(=O)NCCCn1ccnc1 Chemical compound CC(=O)NCCCn1ccnc1 WROYMNFAZWHLSZ-UHFFFAOYSA-N 0.000 description 2
- HACUVEBLIVRVFJ-UHFFFAOYSA-N CC(C)N1CCC(CC1)N1CCCN(CC1)c1cccc(n1)-c1noc(n1)-c1ccncc1 Chemical compound CC(C)N1CCC(CC1)N1CCCN(CC1)c1cccc(n1)-c1noc(n1)-c1ccncc1 HACUVEBLIVRVFJ-UHFFFAOYSA-N 0.000 description 2
- JOJPSTDQYMIMII-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1 JOJPSTDQYMIMII-UHFFFAOYSA-N 0.000 description 2
- DLFVBJFMPXGRIB-UHFFFAOYSA-N CC(N)=O Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 2
- COOKKJGOGWACMY-UHFFFAOYSA-N CC1=CCc2ccccc21 Chemical compound CC1=CCc2ccccc21 COOKKJGOGWACMY-UHFFFAOYSA-N 0.000 description 2
- GYLDXXLJMRTVSS-UHFFFAOYSA-N CCCCNC(C)=O Chemical compound CCCCNC(C)=O GYLDXXLJMRTVSS-UHFFFAOYSA-N 0.000 description 2
- BKKYNUSOWQQNLX-UHFFFAOYSA-N CCCc1[nH]c(C)nc1C Chemical compound CCCc1[nH]c(C)nc1C BKKYNUSOWQQNLX-UHFFFAOYSA-N 0.000 description 2
- PMDCZENCAXMSOU-UHFFFAOYSA-N CCNC(C)=O Chemical compound CCNC(C)=O PMDCZENCAXMSOU-UHFFFAOYSA-N 0.000 description 2
- 108010017088 CCR5 Receptors Proteins 0.000 description 2
- 102000004274 CCR5 Receptors Human genes 0.000 description 2
- NELFWLUXURRZAY-UHFFFAOYSA-N CCc1[nH]c(C)nc1C Chemical compound CCc1[nH]c(C)nc1C NELFWLUXURRZAY-UHFFFAOYSA-N 0.000 description 2
- CVGAWKYSRYXQOI-UHFFFAOYSA-N CCc1ccccc1Cl Chemical compound CCc1ccccc1Cl CVGAWKYSRYXQOI-UHFFFAOYSA-N 0.000 description 2
- GTWRWXATVFDGPX-UHFFFAOYSA-N CCc1nc(C)[nH]c1C1CC1 Chemical compound CCc1nc(C)[nH]c1C1CC1 GTWRWXATVFDGPX-UHFFFAOYSA-N 0.000 description 2
- MCSAQVGDZLPTBS-UHFFFAOYSA-N CNCc1cccnc1 Chemical compound CNCc1cccnc1 MCSAQVGDZLPTBS-UHFFFAOYSA-N 0.000 description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
- PTBPTNCGZUOCBK-UHFFFAOYSA-N Cc1nc(C)c(C)[nH]1 Chemical compound Cc1nc(C)c(C)[nH]1 PTBPTNCGZUOCBK-UHFFFAOYSA-N 0.000 description 2
- SILULGRRGDGHDF-UHFFFAOYSA-N Cc1nc(C)c(C2CC2)[nH]1 Chemical compound Cc1nc(C)c(C2CC2)[nH]1 SILULGRRGDGHDF-UHFFFAOYSA-N 0.000 description 2
- PHMIILSQQVFWKC-UHFFFAOYSA-N Cc1ncc(-c2ccccc2)[nH]1 Chemical compound Cc1ncc(-c2ccccc2)[nH]1 PHMIILSQQVFWKC-UHFFFAOYSA-N 0.000 description 2
- FWNOUILZZKVNQJ-UHFFFAOYSA-N Cc1ncc(C(C)C)[nH]1 Chemical compound Cc1ncc(C(C)C)[nH]1 FWNOUILZZKVNQJ-UHFFFAOYSA-N 0.000 description 2
- DQZUYCWTUHKARO-UHFFFAOYSA-N Cc1ncc(C2CC2)[nH]1 Chemical compound Cc1ncc(C2CC2)[nH]1 DQZUYCWTUHKARO-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 2
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 208000031886 HIV Infections Diseases 0.000 description 2
- 208000037357 HIV infectious disease Diseases 0.000 description 2
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 2
- 238000000023 Kugelrohr distillation Methods 0.000 description 2
- 239000005511 L01XE05 - Sorafenib Substances 0.000 description 2
- 239000003798 L01XE11 - Pazopanib Substances 0.000 description 2
- IDBNLWRQTVZYTR-UHFFFAOYSA-N N'-hydroxy-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboximidamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=N)NO)CCC1 IDBNLWRQTVZYTR-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- FEYNFHSRETUBEM-UHFFFAOYSA-N N-[3-(1,1-difluoroethyl)phenyl]-1-(4-methoxyphenyl)-3-methyl-5-oxo-4H-pyrazole-4-carboxamide Chemical compound COc1ccc(cc1)N1N=C(C)C(C(=O)Nc2cccc(c2)C(C)(F)F)C1=O FEYNFHSRETUBEM-UHFFFAOYSA-N 0.000 description 2
- 206010029113 Neovascularisation Diseases 0.000 description 2
- 235000019502 Orange oil Nutrition 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000006069 Suzuki reaction reaction Methods 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 108091008605 VEGF receptors Proteins 0.000 description 2
- 102000009484 Vascular Endothelial Growth Factor Receptors Human genes 0.000 description 2
- DOTSVTLLCPXTPA-UHFFFAOYSA-N [6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridin-2-yl]methanol Chemical compound OCC1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 DOTSVTLLCPXTPA-UHFFFAOYSA-N 0.000 description 2
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 2
- 239000012346 acetyl chloride Substances 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 229960002833 aflibercept Drugs 0.000 description 2
- 108010081667 aflibercept Proteins 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- KRMDCWKBEZIMAB-UHFFFAOYSA-N amitriptyline Chemical compound C1CC2=CC=CC=C2C(=CCCN(C)C)C2=CC=CC=C21 KRMDCWKBEZIMAB-UHFFFAOYSA-N 0.000 description 2
- 229960000836 amitriptyline Drugs 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 235000019270 ammonium chloride Nutrition 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 229960003005 axitinib Drugs 0.000 description 2
- RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 description 2
- UGBKOURNNQREPE-UHFFFAOYSA-N azepan-1-amine Chemical compound NN1CCCCCC1 UGBKOURNNQREPE-UHFFFAOYSA-N 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- GDPSCBPOCONUDM-GFCCVEGCSA-N benzyl (3r)-3-formylpyrrolidine-1-carboxylate Chemical compound C1[C@H](C=O)CCN1C(=O)OCC1=CC=CC=C1 GDPSCBPOCONUDM-GFCCVEGCSA-N 0.000 description 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 210000003995 blood forming stem cell Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 2
- 125000001246 bromo group Chemical group Br* 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 2
- DVECBJCOGJRVPX-UHFFFAOYSA-N butyryl chloride Chemical compound CCCC(Cl)=O DVECBJCOGJRVPX-UHFFFAOYSA-N 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 2
- 229960002412 cediranib Drugs 0.000 description 2
- ZOOSILUVXHVRJE-UHFFFAOYSA-N cyclopropanecarbonyl chloride Chemical compound ClC(=O)C1CC1 ZOOSILUVXHVRJE-UHFFFAOYSA-N 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 229950005778 dovitinib Drugs 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000003511 endothelial effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012458 free base Substances 0.000 description 2
- 230000005714 functional activity Effects 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- BRZYSWJRSDMWLG-CAXSIQPQSA-N geneticin Chemical compound O1C[C@@](O)(C)[C@H](NC)[C@@H](O)[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(C)O)O2)N)[C@@H](N)C[C@H]1N BRZYSWJRSDMWLG-CAXSIQPQSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- VHHHONWQHHHLTI-UHFFFAOYSA-N hexachloroethane Chemical compound ClC(Cl)(Cl)C(Cl)(Cl)Cl VHHHONWQHHHLTI-UHFFFAOYSA-N 0.000 description 2
- 238000000589 high-performance liquid chromatography-mass spectrometry Methods 0.000 description 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 2
- 125000002632 imidazolidinyl group Chemical group 0.000 description 2
- 238000000099 in vitro assay Methods 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 2
- 238000001802 infusion Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 201000002364 leukopenia Diseases 0.000 description 2
- 231100001022 leukopenia Toxicity 0.000 description 2
- 229940076783 lucentis Drugs 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- GSNHKUDZZFZSJB-QYOOZWMWSA-N maraviroc Chemical compound CC(C)C1=NN=C(C)N1[C@@H]1C[C@H](N2CC[C@H](NC(=O)C3CCC(F)(F)CC3)C=3C=CC=CC=3)CC[C@H]2C1 GSNHKUDZZFZSJB-QYOOZWMWSA-N 0.000 description 2
- 229960004710 maraviroc Drugs 0.000 description 2
- YVXLFEZHQXYOAR-UHFFFAOYSA-N methyl 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxylate Chemical compound COC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 YVXLFEZHQXYOAR-UHFFFAOYSA-N 0.000 description 2
- TWUXBVMXSBEKHA-UHFFFAOYSA-N methyl 6-chloropyridine-2-carboxylate Chemical compound COC(=O)C1=CC=CC(Cl)=N1 TWUXBVMXSBEKHA-UHFFFAOYSA-N 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- RAHBGWKEPAQNFF-UHFFFAOYSA-N motesanib Chemical compound C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 RAHBGWKEPAQNFF-UHFFFAOYSA-N 0.000 description 2
- 229950003968 motesanib Drugs 0.000 description 2
- OMCUPXRCMTUDHI-UHFFFAOYSA-N n'-hydroxycyclopropanecarboximidamide Chemical compound ON=C(N)C1CC1 OMCUPXRCMTUDHI-UHFFFAOYSA-N 0.000 description 2
- AKEDTDNQRINSPB-UHFFFAOYSA-N n,n-dibenzyl-2-fluorocyclopentan-1-amine Chemical compound FC1CCCC1N(CC=1C=CC=CC=1)CC1=CC=CC=C1 AKEDTDNQRINSPB-UHFFFAOYSA-N 0.000 description 2
- HHDXJGUSQRHJDS-UHFFFAOYSA-N n-(1,3-oxazol-2-ylmethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2OC=CN=2)CCC1 HHDXJGUSQRHJDS-UHFFFAOYSA-N 0.000 description 2
- PSTJLCFEKWOKLP-UHFFFAOYSA-N n-(1,3-oxazol-4-ylmethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2N=COC=2)CCC1 PSTJLCFEKWOKLP-UHFFFAOYSA-N 0.000 description 2
- BTARCZQJCRIEEP-UHFFFAOYSA-N n-(2,2-difluoroethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC(F)F)CCC1 BTARCZQJCRIEEP-UHFFFAOYSA-N 0.000 description 2
- RBJGXMDVHIMVRE-UHFFFAOYSA-N n-(2-cyanoethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCCC#N)CCC1 RBJGXMDVHIMVRE-UHFFFAOYSA-N 0.000 description 2
- PYDYMCRNZCUTJV-UHFFFAOYSA-N n-(2-fluoroethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCCF)CCC1 PYDYMCRNZCUTJV-UHFFFAOYSA-N 0.000 description 2
- HEEPHFWFZAZUDF-UHFFFAOYSA-N n-(2-hydroxyphenyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C(=CC=CC=2)O)CCC1 HEEPHFWFZAZUDF-UHFFFAOYSA-N 0.000 description 2
- UQZYGJUCJCGROH-UHFFFAOYSA-N n-(2-methoxyethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound COCCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 UQZYGJUCJCGROH-UHFFFAOYSA-N 0.000 description 2
- ZULIVDWIWWAEOE-UHFFFAOYSA-N n-(2-methylpropyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CC(C)CNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 ZULIVDWIWWAEOE-UHFFFAOYSA-N 0.000 description 2
- LOVQHMZIXHHXLW-UHFFFAOYSA-N n-(2-methylpyridin-4-yl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=C(C)N=CC=2)CCC1 LOVQHMZIXHHXLW-UHFFFAOYSA-N 0.000 description 2
- JPAYPGWOHSJKPS-UHFFFAOYSA-N n-(2-oxohexyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CCCCC(=O)CNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 JPAYPGWOHSJKPS-UHFFFAOYSA-N 0.000 description 2
- DZMZIHIGCOIEKY-UHFFFAOYSA-N n-(3-imidazol-1-ylpropyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCCCN2C=NC=C2)CCC1 DZMZIHIGCOIEKY-UHFFFAOYSA-N 0.000 description 2
- OHMXPZCBNCBCGX-UHFFFAOYSA-N n-(3-methoxypropyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound COCCCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 OHMXPZCBNCBCGX-UHFFFAOYSA-N 0.000 description 2
- FASOEHKXYVPCJE-UHFFFAOYSA-N n-(3-methylpyridin-4-yl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C(=CN=CC=2)C)CCC1 FASOEHKXYVPCJE-UHFFFAOYSA-N 0.000 description 2
- VFOJWTZFKHJTIY-UHFFFAOYSA-N n-(4-chlorophenyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CC(Cl)=CC=2)CCC1 VFOJWTZFKHJTIY-UHFFFAOYSA-N 0.000 description 2
- FMASTMURQSHELY-UHFFFAOYSA-N n-(4-fluoro-2-methylphenyl)-3-methyl-n-[(2-methyl-1h-indol-4-yl)methyl]pyridine-4-carboxamide Chemical compound C1=CC=C2NC(C)=CC2=C1CN(C=1C(=CC(F)=CC=1)C)C(=O)C1=CC=NC=C1C FMASTMURQSHELY-UHFFFAOYSA-N 0.000 description 2
- LXRUYWFRCLYDIG-UHFFFAOYSA-N n-(4-methoxyphenyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1=CC(OC)=CC=C1NC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 LXRUYWFRCLYDIG-UHFFFAOYSA-N 0.000 description 2
- DADPLTADIYXQLH-UHFFFAOYSA-N n-(4-methylphenyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CC(C)=CC=2)CCC1 DADPLTADIYXQLH-UHFFFAOYSA-N 0.000 description 2
- FENLHMSMQVGGPP-UHFFFAOYSA-N n-(cyclopropylmethyl)-2-(1,4-diazepan-1-yl)pyridine-4-carboxamide Chemical compound C=1C=NC(N2CCNCCC2)=CC=1C(=O)NCC1CC1 FENLHMSMQVGGPP-UHFFFAOYSA-N 0.000 description 2
- RGQHUVUSDWCNLI-UHFFFAOYSA-N n-(cyclopropylmethyl)-2-(4-piperidin-4-yl-1,4-diazepan-1-yl)pyridine-4-carboxamide Chemical compound C=1C=NC(N2CCN(CCC2)C2CCNCC2)=CC=1C(=O)NCC1CC1 RGQHUVUSDWCNLI-UHFFFAOYSA-N 0.000 description 2
- ONDNRLOTYRZYGF-UHFFFAOYSA-N n-(cyclopropylmethyl)-5-methoxy-6-(4-piperidin-4-yl-1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound COC1=CC=C(C(=O)NCC2CC2)N=C1N(CC1)CCCN1C1CCNCC1 ONDNRLOTYRZYGF-UHFFFAOYSA-N 0.000 description 2
- QSFNDNQJBNDTEZ-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(1,4-diazepan-1-yl)-3-methylpyridine-2-carboxamide Chemical compound CC1=CC=C(N2CCNCCC2)N=C1C(=O)NCC1CC1 QSFNDNQJBNDTEZ-UHFFFAOYSA-N 0.000 description 2
- HQDPMOMXHFNMRO-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(1,4-diazepan-1-yl)-5-methoxypyridine-2-carboxamide Chemical compound COC1=CC=C(C(=O)NCC2CC2)N=C1N1CCCNCC1 HQDPMOMXHFNMRO-UHFFFAOYSA-N 0.000 description 2
- FZXAGBZPVLQCGU-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(4,10-diazabicyclo[4.3.1]decan-4-yl)pyridine-2-carboxamide Chemical compound C=1C=CC(N2CC3CCCC(N3)CC2)=NC=1C(=O)NCC1CC1 FZXAGBZPVLQCGU-UHFFFAOYSA-N 0.000 description 2
- IRAZFLNGYCLFBD-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(4-piperidin-4-yl-1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCNCC2)=NC=1C(=O)NCC1CC1 IRAZFLNGYCLFBD-UHFFFAOYSA-N 0.000 description 2
- KHQSOOWQNVXGSO-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(5-methyl-1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound C1CNC(C)CCN1C1=CC=CC(C(=O)NCC2CC2)=N1 KHQSOOWQNVXGSO-UHFFFAOYSA-N 0.000 description 2
- AIHKHOCTYSYKBZ-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(6-hydroxy-1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound C1C(O)CNCCN1C1=CC=CC(C(=O)NCC2CC2)=N1 AIHKHOCTYSYKBZ-UHFFFAOYSA-N 0.000 description 2
- KZBZMHSSWUDPFI-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(7-methyl-1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound CC1CCNCCN1C1=CC=CC(C(=O)NCC2CC2)=N1 KZBZMHSSWUDPFI-UHFFFAOYSA-N 0.000 description 2
- COZMYYAVMSBUOG-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[10-(1-propan-2-ylpiperidin-4-yl)-4,10-diazabicyclo[4.3.1]decan-4-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1C2CCCC1CCN(C=1N=C(C=CC=1)C(=O)NCC1CC1)C2 COZMYYAVMSBUOG-UHFFFAOYSA-N 0.000 description 2
- LRWGGZFVIHHVRY-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[3-(1-propan-2-ylpiperidin-4-yl)-3,6-diazabicyclo[3.2.1]octan-6-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CC(N(C2)C=3N=C(C=CC=3)C(=O)NCC3CC3)CC2C1 LRWGGZFVIHHVRY-UHFFFAOYSA-N 0.000 description 2
- LKRABTXDERGOTC-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[3-methyl-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1C(C)CN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 LKRABTXDERGOTC-UHFFFAOYSA-N 0.000 description 2
- BJVRBHWXBQCECE-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-(1-pentan-3-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(CC)CC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 BJVRBHWXBQCECE-UHFFFAOYSA-N 0.000 description 2
- RRUTYWLNFYFUPN-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(1,1-difluoropropan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C(F)F)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 RRUTYWLNFYFUPN-UHFFFAOYSA-N 0.000 description 2
- DNDXGBICVPDZIL-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(1,3-difluoropropan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(CF)CF)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 DNDXGBICVPDZIL-UHFFFAOYSA-N 0.000 description 2
- CXDFICOPUWBTQQ-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(1-fluoropropan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(CF)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 CXDFICOPUWBTQQ-UHFFFAOYSA-N 0.000 description 2
- CGDQDVQOJMKCAO-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(1-methoxypropan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)COC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 CGDQDVQOJMKCAO-UHFFFAOYSA-N 0.000 description 2
- UUEAVSHIIHXNTB-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(2-fluorocyclopentyl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound FC1CCCC1N1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CC2)CC1 UUEAVSHIIHXNTB-UHFFFAOYSA-N 0.000 description 2
- DGLUSUYKMAXEBU-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(2-methoxyethyl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(CCOC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 DGLUSUYKMAXEBU-UHFFFAOYSA-N 0.000 description 2
- HXGDMWAJBXHPMF-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(4,4,4-trifluorobutan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(CC(F)(F)F)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 HXGDMWAJBXHPMF-UHFFFAOYSA-N 0.000 description 2
- LOOYIPQJFNSIEJ-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-(oxolan-3-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCN(CC2)C2COCC2)=NC=1C(=O)NCC1CC1 LOOYIPQJFNSIEJ-UHFFFAOYSA-N 0.000 description 2
- DEODWOMJVYYSEW-HHHXNRCGSA-N n-(cyclopropylmethyl)-6-[4-[1-[(1r)-2,3-dihydro-1h-inden-1-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCN(CC2)[C@H]2C3=CC=CC=C3CC2)=NC=1C(=O)NCC1CC1 DEODWOMJVYYSEW-HHHXNRCGSA-N 0.000 description 2
- DEODWOMJVYYSEW-MHZLTWQESA-N n-(cyclopropylmethyl)-6-[4-[1-[(1s)-2,3-dihydro-1h-inden-1-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCN(CC2)[C@@H]2C3=CC=CC=C3CC2)=NC=1C(=O)NCC1CC1 DEODWOMJVYYSEW-MHZLTWQESA-N 0.000 description 2
- NSGQTIGMSQJNPN-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-[(2-methoxyphenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound COC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CC2)CC1 NSGQTIGMSQJNPN-UHFFFAOYSA-N 0.000 description 2
- VDVIKFHHJNWFIU-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-[(2-methylphenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CC1=CC=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CC2)CC1 VDVIKFHHJNWFIU-UHFFFAOYSA-N 0.000 description 2
- LWZPJRZBOQTALO-KRWDZBQOSA-N n-(cyclopropylmethyl)-6-[4-[1-[(2s)-1,1,1-trifluoropropan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN([C@@H](C)C(F)(F)F)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 LWZPJRZBOQTALO-KRWDZBQOSA-N 0.000 description 2
- DQKXHIIZISWEJA-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1=CC(F)=CC=C1CN1CCC(N2CCN(CCC2)C=2N=C(C=CC=2)C(=O)NCC2CC2)CC1 DQKXHIIZISWEJA-UHFFFAOYSA-N 0.000 description 2
- VEOABQHIWNGQJX-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[3-(1,3-dioxoisoindol-2-yl)propyl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCCN3C(C4=CC=CC=C4C3=O)=O)CCC2)=NC=1C(=O)NCC1CC1 VEOABQHIWNGQJX-UHFFFAOYSA-N 0.000 description 2
- ZIIKXOULEZWBIK-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[3-(3,3-difluoropyrrolidin-1-yl)propyl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1C(F)(F)CCN1CCCN1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 ZIIKXOULEZWBIK-UHFFFAOYSA-N 0.000 description 2
- QZAJIESSTXFFGW-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-[3-(3,4-dihydro-1h-isoquinolin-2-yl)propyl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCCN3CC4=CC=CC=C4CC3)CCC2)=NC=1C(=O)NCC1CC1 QZAJIESSTXFFGW-UHFFFAOYSA-N 0.000 description 2
- KUQXSGCAJZKJFU-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[7-methyl-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)C(C)CC1 KUQXSGCAJZKJFU-UHFFFAOYSA-N 0.000 description 2
- NZVWUVSZFXUUMG-UHFFFAOYSA-N n-(furan-2-ylmethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2OC=CC=2)CCC1 NZVWUVSZFXUUMG-UHFFFAOYSA-N 0.000 description 2
- ZZCUVLPMGYVRRM-UHFFFAOYSA-N n-(oxan-4-yl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC2CCOCC2)CCC1 ZZCUVLPMGYVRRM-UHFFFAOYSA-N 0.000 description 2
- GBUHFGKQEJUIHN-UHFFFAOYSA-N n-(oxan-4-ylmethyl)-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CCOCC2)CCC1 GBUHFGKQEJUIHN-UHFFFAOYSA-N 0.000 description 2
- OCQGYYCPSZACAI-UHFFFAOYSA-N n-(pyridin-3-ylmethyl)-6-[4-[1-(1,1,1-trifluoro-2-methylpropan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)(C)C(F)(F)F)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CCC1 OCQGYYCPSZACAI-UHFFFAOYSA-N 0.000 description 2
- VYNPVMVJEXJNBL-UHFFFAOYSA-N n-(pyridin-3-ylmethyl)-6-[4-[1-(4,4,4-trifluorobutan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(CC(F)(F)F)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CCC1 VYNPVMVJEXJNBL-UHFFFAOYSA-N 0.000 description 2
- BVCQBIPWEWZPQG-IBGZPJMESA-N n-(pyridin-3-ylmethyl)-6-[4-[1-[(2s)-1,1,1-trifluoropropan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN([C@@H](C)C(F)(F)F)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2C=NC=CC=2)CCC1 BVCQBIPWEWZPQG-IBGZPJMESA-N 0.000 description 2
- AGCAOFXBXKDIQY-UHFFFAOYSA-N n-[(1-methylimidazol-2-yl)methyl]-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC=2N(C=CN=2)C)CCC1 AGCAOFXBXKDIQY-UHFFFAOYSA-N 0.000 description 2
- QZIHACHZPQJMPM-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCCN(C)C)CCC1 QZIHACHZPQJMPM-UHFFFAOYSA-N 0.000 description 2
- DHAMCMFYXIGPIM-UHFFFAOYSA-N n-butyl-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CCCCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 DHAMCMFYXIGPIM-UHFFFAOYSA-N 0.000 description 2
- ZKNJXBFUGFCEDS-UHFFFAOYSA-N n-butyl-6-[4-[(4-propan-2-ylmorpholin-2-yl)methyl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CCCCNC(=O)C1=CC=CC(N2CCN(CC3OCCN(C3)C(C)C)CCC2)=N1 ZKNJXBFUGFCEDS-UHFFFAOYSA-N 0.000 description 2
- FHGDHXBNJHAMCI-UHFFFAOYSA-N n-butyl-6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CCCCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 FHGDHXBNJHAMCI-UHFFFAOYSA-N 0.000 description 2
- FEJVGEHNFCKXLG-SFHVURJKSA-N n-butyl-6-[4-[1-[(2s)-1,1,1-trifluoropropan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CCCCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)[C@@H](C)C(F)(F)F)=N1 FEJVGEHNFCKXLG-SFHVURJKSA-N 0.000 description 2
- NZAKRQHQJDUMGH-UHFFFAOYSA-N n-butyl-6-chloropyridine-2-carboxamide Chemical compound CCCCNC(=O)C1=CC=CC(Cl)=N1 NZAKRQHQJDUMGH-UHFFFAOYSA-N 0.000 description 2
- WRDGZWMUGMQDKR-UHFFFAOYSA-N n-cyclopropyl-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC2CC2)CCC1 WRDGZWMUGMQDKR-UHFFFAOYSA-N 0.000 description 2
- PFLUTSXAXNYKAS-UHFFFAOYSA-N n-ethyl-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CCNC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 PFLUTSXAXNYKAS-UHFFFAOYSA-N 0.000 description 2
- WGEURXWPKAKLDC-UHFFFAOYSA-N n-methoxy-n-methyl-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound CON(C)C(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 WGEURXWPKAKLDC-UHFFFAOYSA-N 0.000 description 2
- OAVZOULBJFUULS-UHFFFAOYSA-N n-phenyl-6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CC=CC=2)CCC1 OAVZOULBJFUULS-UHFFFAOYSA-N 0.000 description 2
- DVUKLQKJKISLSU-GOSISDBHSA-N n-pyridin-4-yl-6-[4-[1-[(2r)-1,1,1-trifluoropropan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN([C@H](C)C(F)(F)F)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 DVUKLQKJKISLSU-GOSISDBHSA-N 0.000 description 2
- DVUKLQKJKISLSU-SFHVURJKSA-N n-pyridin-4-yl-6-[4-[1-[(2s)-1,1,1-trifluoropropan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN([C@@H](C)C(F)(F)F)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 DVUKLQKJKISLSU-SFHVURJKSA-N 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 210000004498 neuroglial cell Anatomy 0.000 description 2
- 208000021722 neuropathic pain Diseases 0.000 description 2
- NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 description 2
- 229940127240 opiate Drugs 0.000 description 2
- 239000010502 orange oil Substances 0.000 description 2
- 125000004430 oxygen atom Chemical group O* 0.000 description 2
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 description 2
- 229960000639 pazopanib Drugs 0.000 description 2
- XNLICIUVMPYHGG-UHFFFAOYSA-N pentan-2-one Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 description 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 2
- IVDFJHOHABJVEH-UHFFFAOYSA-N pinacol Chemical compound CC(C)(O)C(C)(C)O IVDFJHOHABJVEH-UHFFFAOYSA-N 0.000 description 2
- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 description 2
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- 229960003787 sorafenib Drugs 0.000 description 2
- 238000010186 staining Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008223 sterile water Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 2
- 229960001796 sunitinib Drugs 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 229950004186 telatinib Drugs 0.000 description 2
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 2
- XXDCECHWRUGWMW-OAQYLSRUSA-N tert-butyl (2r)-2-[[4-[6-(pyridin-4-ylcarbamoyl)pyridin-2-yl]-1,4-diazepan-1-yl]methyl]morpholine-4-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCO[C@@H]1CN1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 XXDCECHWRUGWMW-OAQYLSRUSA-N 0.000 description 2
- YPZOMKMTAJQJJZ-UHFFFAOYSA-N tert-butyl 2-[[4-[6-(butylcarbamoyl)pyridin-2-yl]-1,4-diazepan-1-yl]methyl]morpholine-4-carboxylate Chemical compound CCCCNC(=O)C1=CC=CC(N2CCN(CC3OCCN(C3)C(=O)OC(C)(C)C)CCC2)=N1 YPZOMKMTAJQJJZ-UHFFFAOYSA-N 0.000 description 2
- YWNLSDLQFPOBCF-UHFFFAOYSA-N tert-butyl 3-(4-benzyl-1,4-diazepane-1-carbonyl)-4-methylpiperazine-1-carboxylate Chemical compound CN1CCN(C(=O)OC(C)(C)C)CC1C(=O)N1CCN(CC=2C=CC=CC=2)CCC1 YWNLSDLQFPOBCF-UHFFFAOYSA-N 0.000 description 2
- WGJRBUYGOCBFPM-UHFFFAOYSA-N tert-butyl 3-[2-(4-benzyl-1,4-diazepan-1-yl)-2-oxoethyl]morpholine-4-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCOCC1CC(=O)N1CCN(CC=2C=CC=CC=2)CCC1 WGJRBUYGOCBFPM-UHFFFAOYSA-N 0.000 description 2
- UPNVGFVEJCMXCH-UHFFFAOYSA-N tert-butyl 4-(3,6-diazabicyclo[3.2.2]nonan-6-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1N1C(CNC2)CCC2C1 UPNVGFVEJCMXCH-UHFFFAOYSA-N 0.000 description 2
- IWUQALMLHNUBHS-UHFFFAOYSA-N tert-butyl 4-(3-benzyl-3,6-diazabicyclo[3.2.2]nonan-6-yl)-3-fluoropiperidine-1-carboxylate Chemical compound FC1CN(C(=O)OC(C)(C)C)CCC1N1C(CN(CC=2C=CC=CC=2)C2)CCC2C1 IWUQALMLHNUBHS-UHFFFAOYSA-N 0.000 description 2
- QEPGDAGMZBKRCH-UHFFFAOYSA-N tert-butyl 4-(3-benzyl-3,6-diazabicyclo[3.2.2]nonan-6-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1N1C(CN(CC=2C=CC=CC=2)C2)CCC2C1 QEPGDAGMZBKRCH-UHFFFAOYSA-N 0.000 description 2
- MHGRLBWFKFHHQW-UHFFFAOYSA-N tert-butyl 4-(4-benzyl-1,4-diazepan-1-yl)-3-fluoropiperidine-1-carboxylate Chemical compound FC1CN(C(=O)OC(C)(C)C)CCC1N1CCN(CC=2C=CC=CC=2)CCC1 MHGRLBWFKFHHQW-UHFFFAOYSA-N 0.000 description 2
- IFDVFIZXZXWLTB-UHFFFAOYSA-N tert-butyl 4-[4-[6-(pyridin-4-ylcarbamoyl)pyridin-2-yl]piperazin-1-yl]azepane-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCCC1N1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CC1 IFDVFIZXZXWLTB-UHFFFAOYSA-N 0.000 description 2
- SVMXIQUBNSPVCB-UHFFFAOYSA-N tert-butyl 5-methyl-1,4-diazepane-1-carboxylate Chemical compound CC1CCN(C(=O)OC(C)(C)C)CCN1 SVMXIQUBNSPVCB-UHFFFAOYSA-N 0.000 description 2
- KIJKSEKVVCXVFB-UHFFFAOYSA-N tert-butyl 6-(1,4-diazepan-1-yl)pyridine-2-carboxylate Chemical compound CC(C)(C)OC(=O)C1=CC=CC(N2CCNCCC2)=N1 KIJKSEKVVCXVFB-UHFFFAOYSA-N 0.000 description 2
- UIKGBRWLCZUWLB-UHFFFAOYSA-N tert-butyl 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxylate Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)OC(C)(C)C)CCC1 UIKGBRWLCZUWLB-UHFFFAOYSA-N 0.000 description 2
- AAUPVQIMYVIZET-UHFFFAOYSA-N tert-butyl n-(2-oxohexyl)carbamate Chemical compound CCCCC(=O)CNC(=O)OC(C)(C)C AAUPVQIMYVIZET-UHFFFAOYSA-N 0.000 description 2
- LSTUNJSEFNGJPM-UHFFFAOYSA-N tert-butyl n-[1-[6-(cyclopropylmethylcarbamoyl)pyridin-2-yl]piperidin-4-yl]carbamate Chemical compound C1CC(NC(=O)OC(C)(C)C)CCN1C1=CC=CC(C(=O)NCC2CC2)=N1 LSTUNJSEFNGJPM-UHFFFAOYSA-N 0.000 description 2
- MHBRADVMVAKLBY-UHFFFAOYSA-N tert-butyl n-[1-[6-(pyridin-4-ylcarbamoyl)pyridin-2-yl]piperidin-4-yl]carbamate Chemical compound C1CC(NC(=O)OC(C)(C)C)CCN1C1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 MHBRADVMVAKLBY-UHFFFAOYSA-N 0.000 description 2
- UETSWVCUPQBUGT-UHFFFAOYSA-N tert-butyl n-[1-[methoxy(methyl)amino]-1-oxobutan-2-yl]carbamate Chemical compound CON(C)C(=O)C(CC)NC(=O)OC(C)(C)C UETSWVCUPQBUGT-UHFFFAOYSA-N 0.000 description 2
- XJVZHKXGDQXSNT-UHFFFAOYSA-N tert-butyl n-[2-[methoxy(methyl)amino]-2-oxoethyl]carbamate Chemical compound CON(C)C(=O)CNC(=O)OC(C)(C)C XJVZHKXGDQXSNT-UHFFFAOYSA-N 0.000 description 2
- CKXZPVPIDOJLLM-UHFFFAOYSA-N tert-butyl n-piperidin-4-ylcarbamate Chemical compound CC(C)(C)OC(=O)NC1CCNCC1 CKXZPVPIDOJLLM-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960000940 tivozanib Drugs 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000000844 transformation Methods 0.000 description 2
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 description 2
- XFNJVJPLKCPIBV-UHFFFAOYSA-N trimethylenediamine Chemical compound NCCCN XFNJVJPLKCPIBV-UHFFFAOYSA-N 0.000 description 2
- YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 description 2
- 229950000578 vatalanib Drugs 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- 150000003738 xylenes Chemical class 0.000 description 2
- CBPBJUTWVXLSER-UHFFFAOYSA-N (1-methylindol-2-yl)boronic acid Chemical compound C1=CC=C2N(C)C(B(O)O)=CC2=C1 CBPBJUTWVXLSER-UHFFFAOYSA-N 0.000 description 1
- ZFSXKSSWYSZPGQ-UHFFFAOYSA-N (2-hydroxycyclopentyl)azanium;chloride Chemical compound Cl.NC1CCCC1O ZFSXKSSWYSZPGQ-UHFFFAOYSA-N 0.000 description 1
- LGWMTRPJZFEWCX-ZETCQYMHSA-N (2s)-4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CCO[C@H](C(O)=O)C1 LGWMTRPJZFEWCX-ZETCQYMHSA-N 0.000 description 1
- YRYAXQJXMBETAT-ZETCQYMHSA-N (2s)-4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-ium-2-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCN[C@H](C(O)=O)C1 YRYAXQJXMBETAT-ZETCQYMHSA-N 0.000 description 1
- XJFQACJBMOHUPD-HXUWFJFHSA-N (3r)-1-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]-n-[(1-propan-2-ylpiperidin-4-yl)methyl]pyrrolidin-3-amine Chemical compound C1CN(C(C)C)CCC1CN[C@H]1CN(C=2N=C(C=CC=2)C=2NC=C(N=2)C2CC2)CC1 XJFQACJBMOHUPD-HXUWFJFHSA-N 0.000 description 1
- RBEWCFYUCLOBHN-GOSISDBHSA-N (3r)-1-cyclopentyl-n-[2-[[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethyl]pyrrolidine-3-carboxamide Chemical compound CC=1N=C(C=2N=C(NCCNC(=O)[C@H]3CN(CC3)C3CCCC3)C=CC=2)NC=1C1CC1 RBEWCFYUCLOBHN-GOSISDBHSA-N 0.000 description 1
- SUNNNGFHPGAMBS-CQSZACIVSA-N (3r)-n-[2-[[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethyl]pyrrolidine-3-carboxamide Chemical compound CC=1N=C(C=2N=C(NCCNC(=O)[C@H]3CNCC3)C=CC=2)NC=1C1CC1 SUNNNGFHPGAMBS-CQSZACIVSA-N 0.000 description 1
- UUCZFULDFFWPQL-TZIWHRDSSA-N (3r)-n-[[(3r)-1-cyclopentylpyrrolidin-3-yl]methyl]-1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-amine Chemical compound CC=1NC(C=2N=C(C=CC=2)N2C[C@@H](CC2)NC[C@@H]2CN(CC2)C2CCCC2)=NC=1C1CC1 UUCZFULDFFWPQL-TZIWHRDSSA-N 0.000 description 1
- HRMRQBJUFWFQLX-ZETCQYMHSA-N (3s)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid Chemical compound CC(C)(C)OC(=O)N1CC[C@H](C(O)=O)C1 HRMRQBJUFWFQLX-ZETCQYMHSA-N 0.000 description 1
- LRYVZGVKDOMIKF-JKSUJKDBSA-N (3s)-n-[(3r)-1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl]pyrrolidine-3-carboxamide Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2C[C@@H](CC2)NC(=O)[C@@H]2CNCC2)NC=1C1CC1 LRYVZGVKDOMIKF-JKSUJKDBSA-N 0.000 description 1
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 description 1
- MOWXJLUYGFNTAL-DEOSSOPVSA-N (s)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol Chemical compound N1=NC(OC)=CC=C1[C@@H](O)C1=CC(C=2C3=CC=C(C=C3N=CN=2)N2CCOCC2)=C(F)C=C1Cl MOWXJLUYGFNTAL-DEOSSOPVSA-N 0.000 description 1
- XHILZHAQBOLGFD-UHFFFAOYSA-N 1,1-difluoropropan-2-one Chemical compound CC(=O)C(F)F XHILZHAQBOLGFD-UHFFFAOYSA-N 0.000 description 1
- 150000005071 1,2,4-oxadiazoles Chemical class 0.000 description 1
- IYNBZJOPPCLQGM-UHFFFAOYSA-N 1,3-difluoropropan-2-amine Chemical compound FCC(N)CF IYNBZJOPPCLQGM-UHFFFAOYSA-N 0.000 description 1
- WGVYCXYGPNNUQA-UHFFFAOYSA-N 1-(bromomethyl)-2-methylbenzene Chemical compound CC1=CC=CC=C1CBr WGVYCXYGPNNUQA-UHFFFAOYSA-N 0.000 description 1
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 1
- ASLYMWJFJOFHAX-UHFFFAOYSA-N 1-[6-(4,5-dimethyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound N1C(C)=C(C)N=C1C1=CC=CC(N2CCNCCC2)=N1 ASLYMWJFJOFHAX-UHFFFAOYSA-N 0.000 description 1
- HIMVFRBKHLLWBO-UHFFFAOYSA-N 1-[6-(4-cyclopropyl-5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound CCC=1N=C(C=2N=C(C=CC=2)N2CCNCCC2)NC=1C1CC1 HIMVFRBKHLLWBO-UHFFFAOYSA-N 0.000 description 1
- VQXOFQXZIDKMOC-UHFFFAOYSA-N 1-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound CC=1N=C(C=2N=C(C=CC=2)N2CCNCCC2)NC=1C1CC1 VQXOFQXZIDKMOC-UHFFFAOYSA-N 0.000 description 1
- JVXVFHAXJVIHQR-UHFFFAOYSA-N 1-[6-(4-ethyl-1-methylimidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound CCC1=CN(C)C(C=2N=C(C=CC=2)N2CCNCCC2)=N1 JVXVFHAXJVIHQR-UHFFFAOYSA-N 0.000 description 1
- ABUXRSPFWHKJOL-UHFFFAOYSA-N 1-[6-(4-methyl-1h-pyrazol-5-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane;trihydrochloride Chemical compound Cl.Cl.Cl.C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2C(=CNN=2)C)CCC1 ABUXRSPFWHKJOL-UHFFFAOYSA-N 0.000 description 1
- RCPLPFXYCMJYRP-UHFFFAOYSA-N 1-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound C1CC1C1=CN=C(C=2N=C(C=CC=2)N2CCNCCC2)N1 RCPLPFXYCMJYRP-UHFFFAOYSA-N 0.000 description 1
- SFPLUBFXDRZXED-UHFFFAOYSA-N 1-[6-(5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound N1C(CC)=CN=C1C1=CC=CC(N2CCNCCC2)=N1 SFPLUBFXDRZXED-UHFFFAOYSA-N 0.000 description 1
- MONOSLSGEGKYFT-UHFFFAOYSA-N 1-[6-(5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound N1C(C)=CN=C1C1=CC=CC(N2CCNCCC2)=N1 MONOSLSGEGKYFT-UHFFFAOYSA-N 0.000 description 1
- VWUYRXOYLVSYRN-UHFFFAOYSA-N 1-[6-(5-methyl-1h-imidazol-2-yl)pyridin-2-yl]-4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepane Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC=C(C)N=2)CCC1 VWUYRXOYLVSYRN-UHFFFAOYSA-N 0.000 description 1
- CALFIIAKHRTBHO-UHFFFAOYSA-N 1-[6-(5-phenyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound C1CCNCCN1C1=CC=CC(C=2NC(=CN=2)C=2C=CC=CC=2)=N1 CALFIIAKHRTBHO-UHFFFAOYSA-N 0.000 description 1
- FDVBJPIDDANASF-UHFFFAOYSA-N 1-[6-(5-propyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound N1C(CCC)=CN=C1C1=CC=CC(N2CCNCCC2)=N1 FDVBJPIDDANASF-UHFFFAOYSA-N 0.000 description 1
- SXKXMBSAMOHHEB-UHFFFAOYSA-N 1-[6-(5-tert-butyl-1h-imidazol-2-yl)pyridin-2-yl]-1,4-diazepane Chemical compound N1C(C(C)(C)C)=CN=C1C1=CC=CC(N2CCNCCC2)=N1 SXKXMBSAMOHHEB-UHFFFAOYSA-N 0.000 description 1
- RWCAZKKJQIFNJQ-UHFFFAOYSA-N 1-aminohexan-2-one;hydrochloride Chemical compound Cl.CCCCC(=O)CN RWCAZKKJQIFNJQ-UHFFFAOYSA-N 0.000 description 1
- DKNOPZCYIDBMNY-UHFFFAOYSA-N 1-benzyl-1,4-diazepan-5-one Chemical compound C1CNC(=O)CCN1CC1=CC=CC=C1 DKNOPZCYIDBMNY-UHFFFAOYSA-N 0.000 description 1
- OVQAJYCAXPHYNV-UHFFFAOYSA-N 1-benzyl-3-methylpiperidin-4-one Chemical compound C1CC(=O)C(C)CN1CC1=CC=CC=C1 OVQAJYCAXPHYNV-UHFFFAOYSA-N 0.000 description 1
- BPPZXJZYCOETDA-UHFFFAOYSA-N 1-benzylpiperidin-4-ol Chemical compound C1CC(O)CCN1CC1=CC=CC=C1 BPPZXJZYCOETDA-UHFFFAOYSA-N 0.000 description 1
- YZUPZGFPHUVJKC-UHFFFAOYSA-N 1-bromo-2-methoxyethane Chemical compound COCCBr YZUPZGFPHUVJKC-UHFFFAOYSA-N 0.000 description 1
- ULNDBAJJBDYSOA-UHFFFAOYSA-N 1-cyclopentyl-n-[2-[[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethyl]pyrrolidine-3-carboxamide Chemical compound C1CN(C2CCCC2)CC1C(=O)NCCNC(N=1)=CC=CC=1C(N1)=NC=C1C1CC1 ULNDBAJJBDYSOA-UHFFFAOYSA-N 0.000 description 1
- CUZLJOLBIRPEFB-UHFFFAOYSA-N 1-methoxypropan-2-one Chemical compound COCC(C)=O CUZLJOLBIRPEFB-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- QYDWHEYNBAQBHJ-UHFFFAOYSA-N 1-piperidin-4-yl-1,4-diazepane Chemical compound C1CNCCC1N1CCNCCC1 QYDWHEYNBAQBHJ-UHFFFAOYSA-N 0.000 description 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- KWSMBQIRGSLKBY-UHFFFAOYSA-N 10-benzyl-4,10-diazabicyclo[4.3.1]decane Chemical compound C1NCCC2CCCC1N2CC1=CC=CC=C1 KWSMBQIRGSLKBY-UHFFFAOYSA-N 0.000 description 1
- VKJCJJYNVIYVQR-UHFFFAOYSA-N 2-(3-bromopropyl)isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(CCCBr)C(=O)C2=C1 VKJCJJYNVIYVQR-UHFFFAOYSA-N 0.000 description 1
- SZFLMPBQPGNZBG-UHFFFAOYSA-N 2-(5-tert-butyl-1h-imidazol-2-yl)-6-chloropyridine Chemical compound N1C(C(C)(C)C)=CN=C1C1=CC=CC(Cl)=N1 SZFLMPBQPGNZBG-UHFFFAOYSA-N 0.000 description 1
- VRPJIFMKZZEXLR-UHFFFAOYSA-N 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetic acid Chemical compound CC(C)(C)OC(=O)NCC(O)=O VRPJIFMKZZEXLR-UHFFFAOYSA-N 0.000 description 1
- PNFVIPIQXAIUAY-UHFFFAOYSA-N 2-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid Chemical compound CCC(C(O)=O)NC(=O)OC(C)(C)C PNFVIPIQXAIUAY-UHFFFAOYSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- QVOPNRRQHPWQMF-UHFFFAOYSA-N 2-[4-[(2-methylpropan-2-yl)oxycarbonyl]morpholin-3-yl]acetic acid Chemical compound CC(C)(C)OC(=O)N1CCOCC1CC(O)=O QVOPNRRQHPWQMF-UHFFFAOYSA-N 0.000 description 1
- HDNUDLSZOOSQNG-UHFFFAOYSA-N 2-[6-(1,4-diazepan-1-yl)pyridin-2-yl]-1-methylindole Chemical compound C=1C2=CC=CC=C2N(C)C=1C(N=1)=CC=CC=1N1CCCNCC1 HDNUDLSZOOSQNG-UHFFFAOYSA-N 0.000 description 1
- JTRUZOQZAYUBBY-UHFFFAOYSA-N 2-[6-(1,4-diazepan-1-yl)pyridin-2-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1CCNCCN1C1=CC=CC(C=2NC3=NC=CC=C3C=2)=N1 JTRUZOQZAYUBBY-UHFFFAOYSA-N 0.000 description 1
- AJUYRDNPQLHODC-UHFFFAOYSA-N 2-[6-(1,4-diazepan-1-yl)pyridin-2-yl]-1h-pyrrolo[2,3-c]pyridine Chemical compound C1CCNCCN1C1=CC=CC(C=2NC3=CN=CC=C3C=2)=N1 AJUYRDNPQLHODC-UHFFFAOYSA-N 0.000 description 1
- QBFVEOOMHKWMQE-UHFFFAOYSA-N 2-[6-(1,4-diazepan-1-yl)pyridin-2-yl]-1h-pyrrolo[3,2-b]pyridine Chemical compound C1CCNCCN1C1=CC=CC(C=2NC3=CC=CN=C3C=2)=N1 QBFVEOOMHKWMQE-UHFFFAOYSA-N 0.000 description 1
- IWUMAJOMMFSCEV-UHFFFAOYSA-N 2-[6-(1,4-diazepan-1-yl)pyridin-2-yl]-6-methoxy-1h-indole Chemical compound N1C2=CC(OC)=CC=C2C=C1C(N=1)=CC=CC=1N1CCCNCC1 IWUMAJOMMFSCEV-UHFFFAOYSA-N 0.000 description 1
- MWKKTVGCSDRXFL-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-indole Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC=CC=C3C=2)CCC1 MWKKTVGCSDRXFL-UHFFFAOYSA-N 0.000 description 1
- XVBSKUAAAXWBTI-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-indole-6-carbonitrile Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC(=CC=C3C=2)C#N)CCC1 XVBSKUAAAXWBTI-UHFFFAOYSA-N 0.000 description 1
- ZSYOZUIHQQPNNP-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-pyrrolo[2,3-c]pyridine Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CN=CC=C3C=2)CCC1 ZSYOZUIHQQPNNP-UHFFFAOYSA-N 0.000 description 1
- WNEYNPPOGSMVHM-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-pyrrolo[3,2-b]pyridine Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC=CN=C3C=2)CCC1 WNEYNPPOGSMVHM-UHFFFAOYSA-N 0.000 description 1
- NFHYFRRLHRPMKD-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-pyrrolo[3,2-c]pyridine Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC=NC=C3C=2)CCC1 NFHYFRRLHRPMKD-UHFFFAOYSA-N 0.000 description 1
- KCYUERPUDTYDIB-UHFFFAOYSA-N 2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-3h-benzimidazole-5-carbonitrile Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2NC3=CC(=CC=C3N=2)C#N)CCC1 KCYUERPUDTYDIB-UHFFFAOYSA-N 0.000 description 1
- DSEHPQBQVDLHSK-UHFFFAOYSA-N 2-chloro-4-methylpyrimidine-5-carboxylic acid Chemical compound CC1=NC(Cl)=NC=C1C(O)=O DSEHPQBQVDLHSK-UHFFFAOYSA-N 0.000 description 1
- JKENQVLBZDASGR-UHFFFAOYSA-N 2-chloro-6-(4,5-dimethyl-1h-imidazol-2-yl)pyridine Chemical compound N1C(C)=C(C)N=C1C1=CC=CC(Cl)=N1 JKENQVLBZDASGR-UHFFFAOYSA-N 0.000 description 1
- ZLXLLQTYKBUGLZ-UHFFFAOYSA-N 2-chloro-6-(4-cyclopropyl-5-ethyl-1h-imidazol-2-yl)pyridine Chemical compound CCC=1N=C(C=2N=C(Cl)C=CC=2)NC=1C1CC1 ZLXLLQTYKBUGLZ-UHFFFAOYSA-N 0.000 description 1
- GAXDEKIJRQXXBW-UHFFFAOYSA-N 2-chloro-6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridine Chemical compound CC=1N=C(C=2N=C(Cl)C=CC=2)NC=1C1CC1 GAXDEKIJRQXXBW-UHFFFAOYSA-N 0.000 description 1
- GGCNUIYLBGZGKZ-UHFFFAOYSA-N 2-chloro-6-(4-ethyl-1-methylimidazol-2-yl)pyridine Chemical compound CCC1=CN(C)C(C=2N=C(Cl)C=CC=2)=N1 GGCNUIYLBGZGKZ-UHFFFAOYSA-N 0.000 description 1
- OOUAKJLFLIUJJQ-UHFFFAOYSA-N 2-chloro-6-(4-ethyl-5-methyl-1h-imidazol-2-yl)pyridine Chemical compound CC1=C(CC)NC(C=2N=C(Cl)C=CC=2)=N1 OOUAKJLFLIUJJQ-UHFFFAOYSA-N 0.000 description 1
- OXDIBVHXPLJFKH-UHFFFAOYSA-N 2-chloro-6-(5-cyclopropyl-1h-imidazol-2-yl)pyridine Chemical compound ClC1=CC=CC(C=2NC(=CN=2)C2CC2)=N1 OXDIBVHXPLJFKH-UHFFFAOYSA-N 0.000 description 1
- QBGDBTMDOARBBP-UHFFFAOYSA-N 2-chloro-6-(5-methyl-4-propyl-1h-imidazol-2-yl)pyridine Chemical compound CC1=C(CCC)NC(C=2N=C(Cl)C=CC=2)=N1 QBGDBTMDOARBBP-UHFFFAOYSA-N 0.000 description 1
- MUYYWFWBNVXMKF-UHFFFAOYSA-N 2-chloro-6-(5-phenyl-1h-imidazol-2-yl)pyridine Chemical compound ClC1=CC=CC(C=2NC(=CN=2)C=2C=CC=CC=2)=N1 MUYYWFWBNVXMKF-UHFFFAOYSA-N 0.000 description 1
- SSSDJBDMRAKZCK-UHFFFAOYSA-N 2-chloro-6-(5-propan-2-yl-1h-imidazol-2-yl)pyridine Chemical compound N1C(C(C)C)=CN=C1C1=CC=CC(Cl)=N1 SSSDJBDMRAKZCK-UHFFFAOYSA-N 0.000 description 1
- MGPFZTZBEWYGKS-UHFFFAOYSA-N 2-chloro-6-(5-propyl-1h-imidazol-2-yl)pyridine Chemical compound N1C(CCC)=CN=C1C1=CC=CC(Cl)=N1 MGPFZTZBEWYGKS-UHFFFAOYSA-N 0.000 description 1
- IVBPTWVZMQALCN-UHFFFAOYSA-N 2-chloro-6-[5-(trifluoromethyl)-1h-imidazol-2-yl]pyridine Chemical compound N1C(C(F)(F)F)=CN=C1C1=CC=CC(Cl)=N1 IVBPTWVZMQALCN-UHFFFAOYSA-N 0.000 description 1
- OKDGRDCXVWSXDC-UHFFFAOYSA-N 2-chloropyridine Chemical compound ClC1=CC=CC=N1 OKDGRDCXVWSXDC-UHFFFAOYSA-N 0.000 description 1
- QXCOHSRHFCHCHN-UHFFFAOYSA-N 2-chloropyridine-4-carboxylic acid Chemical compound OC(=O)C1=CC=NC(Cl)=C1 QXCOHSRHFCHCHN-UHFFFAOYSA-N 0.000 description 1
- JWUJQDFVADABEY-UHFFFAOYSA-N 2-methyltetrahydrofuran Chemical compound CC1CCCO1 JWUJQDFVADABEY-UHFFFAOYSA-N 0.000 description 1
- RPKCLSMBVQLWIN-UHFFFAOYSA-N 2-n-methylbenzene-1,2-diamine Chemical compound CNC1=CC=CC=C1N RPKCLSMBVQLWIN-UHFFFAOYSA-N 0.000 description 1
- YYVPZQADFREIFR-UHFFFAOYSA-N 3,3-difluoropyrrolidine;hydrochloride Chemical compound [Cl-].FC1(F)CC[NH2+]C1 YYVPZQADFREIFR-UHFFFAOYSA-N 0.000 description 1
- HCDMJFOHIXMBOV-UHFFFAOYSA-N 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-4,7-dihydropyrrolo[4,5]pyrido[1,2-d]pyrimidin-2-one Chemical compound C=1C2=C3N(CC)C(=O)N(C=4C(=C(OC)C=C(OC)C=4F)F)CC3=CN=C2NC=1CN1CCOCC1 HCDMJFOHIXMBOV-UHFFFAOYSA-N 0.000 description 1
- UBCRJVBLYADWIL-UHFFFAOYSA-N 3-(cyclopentylamino)-n-[2-[[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethyl]propanamide Chemical compound C=1C=CC(C=2NC(=CN=2)C2CC2)=NC=1NCCNC(=O)CCNC1CCCC1 UBCRJVBLYADWIL-UHFFFAOYSA-N 0.000 description 1
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- RQFUZUMFPRMVDX-UHFFFAOYSA-N 3-Bromo-1-propanol Chemical compound OCCCBr RQFUZUMFPRMVDX-UHFFFAOYSA-N 0.000 description 1
- WCFJUSRQHZPVKY-UHFFFAOYSA-N 3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)NCCC(O)=O WCFJUSRQHZPVKY-UHFFFAOYSA-N 0.000 description 1
- XPGGBNZCZBGEPT-UHFFFAOYSA-N 3-[6-(1,4-diazepan-1-yl)pyridin-2-yl]-1h-indole Chemical compound C1CCNCCN1C1=CC=CC(C=2C3=CC=CC=C3NC=2)=N1 XPGGBNZCZBGEPT-UHFFFAOYSA-N 0.000 description 1
- NOEQUPILHPUHRQ-UHFFFAOYSA-N 3-[6-(1,4-diazepan-1-yl)pyridin-2-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1CCNCCN1C1=CC=CC(C=2C3=CC=CN=C3NC=2)=N1 NOEQUPILHPUHRQ-UHFFFAOYSA-N 0.000 description 1
- JDWTUJVSVOTCSJ-UHFFFAOYSA-N 3-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-pyrrolo[2,3-b]pyridine Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C=2C3=CC=CN=C3NC=2)CCC1 JDWTUJVSVOTCSJ-UHFFFAOYSA-N 0.000 description 1
- JFUOAGBSDGCVES-UHFFFAOYSA-N 3-but-2-enyl-4-methylpyrrolidine-2,5-dione Chemical compound CC=CCC1C(C)C(=O)NC1=O JFUOAGBSDGCVES-UHFFFAOYSA-N 0.000 description 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 1
- 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- BTXXTMOWISPQSJ-UHFFFAOYSA-N 4,4,4-trifluorobutan-2-one Chemical compound CC(=O)CC(F)(F)F BTXXTMOWISPQSJ-UHFFFAOYSA-N 0.000 description 1
- QDIDOFPVTHIPJR-UHFFFAOYSA-N 4-[2-(trifluoromethyl)pyrrolidin-1-yl]cyclohexan-1-one Chemical compound FC(F)(F)C1CCCN1C1CCC(=O)CC1 QDIDOFPVTHIPJR-UHFFFAOYSA-N 0.000 description 1
- ZABUESQWVKDITO-UHFFFAOYSA-N 4-aminohexan-3-one;2,2,2-trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.CCC(N)C(=O)CC ZABUESQWVKDITO-UHFFFAOYSA-N 0.000 description 1
- GAMYYCRTACQSBR-UHFFFAOYSA-N 4-azabenzimidazole Chemical group C1=CC=C2NC=NC2=N1 GAMYYCRTACQSBR-UHFFFAOYSA-N 0.000 description 1
- HVCNXQOWACZAFN-UHFFFAOYSA-N 4-ethylmorpholine Chemical compound CCN1CCOCC1 HVCNXQOWACZAFN-UHFFFAOYSA-N 0.000 description 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 1
- RDGIABKZGSKWCC-UHFFFAOYSA-N 4-pyrrolidin-1-ylcyclohexan-1-one Chemical compound C1CC(=O)CCC1N1CCCC1 RDGIABKZGSKWCC-UHFFFAOYSA-N 0.000 description 1
- DQDBZTOGDWCHKF-UHFFFAOYSA-N 5-methoxy-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-indole Chemical compound C=1C2=CC(OC)=CC=C2NC=1C(N=1)=CC=CC=1N(CC1)CCCN1C1CCN(C(C)C)CC1 DQDBZTOGDWCHKF-UHFFFAOYSA-N 0.000 description 1
- FUFZNHHSSMCXCZ-UHFFFAOYSA-N 5-piperidin-4-yl-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole Chemical compound FC(F)(F)C1=CC=CC(C=2N=C(ON=2)C2CCNCC2)=C1 FUFZNHHSSMCXCZ-UHFFFAOYSA-N 0.000 description 1
- OWXUXRFQXNFZPA-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)-n-(1,3-thiazol-2-ylmethyl)pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCNCCC2)=NC=1C(=O)NCC1=NC=CS1 OWXUXRFQXNFZPA-UHFFFAOYSA-N 0.000 description 1
- UCZMIZFSPJNPAX-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)-n-(2,6-dimethylpyridin-4-yl)pyridine-2-carboxamide Chemical compound CC1=NC(C)=CC(NC(=O)C=2N=C(C=CC=2)N2CCNCCC2)=C1 UCZMIZFSPJNPAX-UHFFFAOYSA-N 0.000 description 1
- SARIDMJKWZXCIT-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)-n-(2-methylpyridin-4-yl)pyridine-2-carboxamide Chemical compound C1=NC(C)=CC(NC(=O)C=2N=C(C=CC=2)N2CCNCCC2)=C1 SARIDMJKWZXCIT-UHFFFAOYSA-N 0.000 description 1
- CZKMNHNWMZYQNI-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)-n-(3-methylpyridin-4-yl)pyridine-2-carboxamide Chemical compound CC1=CN=CC=C1NC(=O)C1=CC=CC(N2CCNCCC2)=N1 CZKMNHNWMZYQNI-UHFFFAOYSA-N 0.000 description 1
- NOJGDWJXGOAORO-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)-n-(pyridin-3-ylmethyl)pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCNCCC2)=NC=1C(=O)NCC1=CC=CN=C1 NOJGDWJXGOAORO-UHFFFAOYSA-N 0.000 description 1
- IJHYKYDJDHUMFB-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)-n-ethylpyridine-2-carboxamide Chemical compound CCNC(=O)C1=CC=CC(N2CCNCCC2)=N1 IJHYKYDJDHUMFB-UHFFFAOYSA-N 0.000 description 1
- FULCQLXILFPZHU-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2CCNCCC2)=NC=1C(=O)NC1=CC=NC=C1 FULCQLXILFPZHU-UHFFFAOYSA-N 0.000 description 1
- LUAYTTZDHCNYMG-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)pyridine-2-carbonitrile Chemical compound N#CC1=CC=CC(N2CCNCCC2)=N1 LUAYTTZDHCNYMG-UHFFFAOYSA-N 0.000 description 1
- XKCDXNCWGIRTRB-UHFFFAOYSA-N 6-(1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound NC(=O)C1=CC=CC(N2CCNCCC2)=N1 XKCDXNCWGIRTRB-UHFFFAOYSA-N 0.000 description 1
- VPSHTDCLBCGVDC-UHFFFAOYSA-N 6-(2-aminoethylamino)-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound NCCNC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 VPSHTDCLBCGVDC-UHFFFAOYSA-N 0.000 description 1
- ROZPCVNZSRTJQJ-UHFFFAOYSA-N 6-(3-aminopropylamino)-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound NCCCNC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 ROZPCVNZSRTJQJ-UHFFFAOYSA-N 0.000 description 1
- QBSYHRDZVSSERE-GOSISDBHSA-N 6-[(3r)-3-(piperidin-4-ylmethylamino)pyrrolidin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2C[C@@H](CC2)NCC2CCNCC2)=NC=1C(=O)NC1=CC=NC=C1 QBSYHRDZVSSERE-GOSISDBHSA-N 0.000 description 1
- UDWYARWZJMKAIY-JOCHJYFZSA-N 6-[(3r)-3-[(1-cyclopentylpiperidin-4-yl)methylamino]pyrrolidin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C=1C=CC(N2C[C@@H](CC2)NCC2CCN(CC2)C2CCCC2)=NC=1C(=O)NC1=CC=NC=C1 UDWYARWZJMKAIY-JOCHJYFZSA-N 0.000 description 1
- HLTXYNFLTGUHGP-UHFFFAOYSA-N 6-[2-[(1-propan-2-ylazepan-4-yl)amino]ethylamino]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCCC1NCCNC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 HLTXYNFLTGUHGP-UHFFFAOYSA-N 0.000 description 1
- IBMPQRHWNQPWFK-UHFFFAOYSA-N 6-[3-[(1-propan-2-ylpiperidin-4-yl)amino]propylamino]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1NCCCNC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 IBMPQRHWNQPWFK-UHFFFAOYSA-N 0.000 description 1
- DITWTMUBSNXRSZ-UHFFFAOYSA-N 6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carbonitrile Chemical compound C1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C#N)CCC1 DITWTMUBSNXRSZ-UHFFFAOYSA-N 0.000 description 1
- FICQLXSPVOFPAJ-UHFFFAOYSA-N 6-[4-[(1-propan-2-ylpiperidin-4-yl)amino]piperidin-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1NC1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CC1 FICQLXSPVOFPAJ-UHFFFAOYSA-N 0.000 description 1
- RUMMVQVEUWDKJL-UHFFFAOYSA-N 6-[4-[(2-chlorophenyl)methylamino]piperidin-1-yl]-n-(cyclopropylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC=C1CNC1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CC1 RUMMVQVEUWDKJL-UHFFFAOYSA-N 0.000 description 1
- XIMMSWNZWYOXRL-QGZVFWFLSA-N 6-[4-[1-[(2r)-butan-2-yl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carbonitrile Chemical compound C1CN([C@H](C)CC)CCC1N1CCN(C=2N=C(C=CC=2)C#N)CCC1 XIMMSWNZWYOXRL-QGZVFWFLSA-N 0.000 description 1
- FXRQTMMBLWXLID-OAQYLSRUSA-N 6-[4-[[(2r)-4-propan-2-ylmorpholin-2-yl]methyl]-1,4-diazepan-1-yl]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1N(C(C)C)CCO[C@@H]1CN1CCN(C=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 FXRQTMMBLWXLID-OAQYLSRUSA-N 0.000 description 1
- UDPSHQHZQOENHR-UHFFFAOYSA-N 6-[[1-(1-propan-2-ylpiperidin-4-yl)piperidin-3-yl]amino]-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound C1CN(C(C)C)CCC1N1CC(NC=2N=C(C=CC=2)C(=O)NC=2C=CN=CC=2)CCC1 UDPSHQHZQOENHR-UHFFFAOYSA-N 0.000 description 1
- XURXQNUIGWHWHU-UHFFFAOYSA-N 6-bromopyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC=CC(Br)=N1 XURXQNUIGWHWHU-UHFFFAOYSA-N 0.000 description 1
- ODSPBBWQVLWOPG-UHFFFAOYSA-N 6-chloro-3-methylpyridine-2-carboxylic acid Chemical compound CC1=CC=C(Cl)N=C1C(O)=O ODSPBBWQVLWOPG-UHFFFAOYSA-N 0.000 description 1
- IDIRHQNTRMGBPJ-UHFFFAOYSA-N 6-chloro-4-methylpyridine-2-carboxylic acid Chemical compound CC1=CC(Cl)=NC(C(O)=O)=C1 IDIRHQNTRMGBPJ-UHFFFAOYSA-N 0.000 description 1
- NLIPRLLFFMVAMU-UHFFFAOYSA-N 6-chloro-5-methoxypyridine-2-carboxylic acid Chemical compound COC1=CC=C(C(O)=O)N=C1Cl NLIPRLLFFMVAMU-UHFFFAOYSA-N 0.000 description 1
- CGIRNEKOUZNDCO-UHFFFAOYSA-N 6-chloro-n-(1,3-thiazol-2-ylmethyl)pyridine-2-carboxamide Chemical compound ClC1=CC=CC(C(=O)NCC=2SC=CN=2)=N1 CGIRNEKOUZNDCO-UHFFFAOYSA-N 0.000 description 1
- FCJNCYQEXHIIPN-UHFFFAOYSA-N 6-chloro-n-(2,6-dimethylpyridin-4-yl)pyridine-2-carboxamide Chemical compound CC1=NC(C)=CC(NC(=O)C=2N=C(Cl)C=CC=2)=C1 FCJNCYQEXHIIPN-UHFFFAOYSA-N 0.000 description 1
- SDYIDEXACJVPNM-UHFFFAOYSA-N 6-chloro-n-(2-methylpyridin-4-yl)pyridine-2-carboxamide Chemical compound C1=NC(C)=CC(NC(=O)C=2N=C(Cl)C=CC=2)=C1 SDYIDEXACJVPNM-UHFFFAOYSA-N 0.000 description 1
- WEAZJMKJHNUADW-UHFFFAOYSA-N 6-chloro-n-(3-methylpyridin-4-yl)pyridine-2-carboxamide Chemical compound CC1=CN=CC=C1NC(=O)C1=CC=CC(Cl)=N1 WEAZJMKJHNUADW-UHFFFAOYSA-N 0.000 description 1
- CCZOOWVBFKEKSF-UHFFFAOYSA-N 6-chloro-n-pyridin-4-ylpyridine-2-carboxamide Chemical compound ClC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 CCZOOWVBFKEKSF-UHFFFAOYSA-N 0.000 description 1
- PGZHSVWXFKKCNR-UHFFFAOYSA-N 6-chloropyridine-2-carbonitrile Chemical compound ClC1=CC=CC(C#N)=N1 PGZHSVWXFKKCNR-UHFFFAOYSA-N 0.000 description 1
- GPSQGRFXCGRAQN-UHFFFAOYSA-N 6-methoxy-2-[6-[4-(1-propan-2-ylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridin-2-yl]-1h-indole Chemical compound N1C2=CC(OC)=CC=C2C=C1C(N=1)=CC=CC=1N(CC1)CCCN1C1CCN(C(C)C)CC1 GPSQGRFXCGRAQN-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 208000010392 Bone Fractures Diseases 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
- YCRPHHFZMBPDEE-UHFFFAOYSA-N C(C)C=1N=C(NC=1CC)C1=CC=CC(=N1)N1CCNCCC1 Chemical compound C(C)C=1N=C(NC=1CC)C1=CC=CC(=N1)N1CCNCCC1 YCRPHHFZMBPDEE-UHFFFAOYSA-N 0.000 description 1
- IQYBFLLLJODSTD-UHFFFAOYSA-N C12=CC=CC=C2N(C(=O)OC(C)(C)C)C=C1C1=CC=CC(Cl)=N1 Chemical compound C12=CC=CC=C2N(C(=O)OC(C)(C)C)C=C1C1=CC=CC(Cl)=N1 IQYBFLLLJODSTD-UHFFFAOYSA-N 0.000 description 1
- QEVNTBKNHAITRW-UHFFFAOYSA-N C1CN(C(=O)OC(C)(C)C)CCCC1NCCNC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 Chemical compound C1CN(C(=O)OC(C)(C)C)CCCC1NCCNC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 QEVNTBKNHAITRW-UHFFFAOYSA-N 0.000 description 1
- ZFFLFZCPMUWSBA-UHFFFAOYSA-N C1CNCCNC1.CCl.CN1CCCNCC1 Chemical compound C1CNCCNC1.CCl.CN1CCCNCC1 ZFFLFZCPMUWSBA-UHFFFAOYSA-N 0.000 description 1
- 238000011740 C57BL/6 mouse Methods 0.000 description 1
- KRCNKSKBQPFVQP-UHFFFAOYSA-N C=1C2=CC(OC)=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 Chemical compound C=1C2=CC(OC)=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 KRCNKSKBQPFVQP-UHFFFAOYSA-N 0.000 description 1
- BOWCTJAPEVGJPP-UHFFFAOYSA-N C=1C2=CC=C(C#N)C=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 Chemical compound C=1C2=CC=C(C#N)C=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 BOWCTJAPEVGJPP-UHFFFAOYSA-N 0.000 description 1
- YEZJRAJEPYYAHT-UHFFFAOYSA-N C=1C2=CC=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 Chemical compound C=1C2=CC=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 YEZJRAJEPYYAHT-UHFFFAOYSA-N 0.000 description 1
- JRIQZOYQUMOBII-UHFFFAOYSA-N C=1C2=CC=CN=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 Chemical compound C=1C2=CC=CN=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 JRIQZOYQUMOBII-UHFFFAOYSA-N 0.000 description 1
- SWCPAOZJYDSPEQ-UHFFFAOYSA-N C=1C2=CC=NC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 Chemical compound C=1C2=CC=NC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 SWCPAOZJYDSPEQ-UHFFFAOYSA-N 0.000 description 1
- DORFFYFYWQBKRJ-UHFFFAOYSA-N C=1C2=CN=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 Chemical compound C=1C2=CN=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 DORFFYFYWQBKRJ-UHFFFAOYSA-N 0.000 description 1
- GPNBMJWFVHPLHT-UHFFFAOYSA-N C=1C2=NC=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 Chemical compound C=1C2=NC=CC=C2N(C(=O)OC(C)(C)C)C=1C1=CC=CC(Cl)=N1 GPNBMJWFVHPLHT-UHFFFAOYSA-N 0.000 description 1
- BNBOUFHCTIFWHN-UHFFFAOYSA-N CC(=O)C(C)Br Chemical compound CC(=O)C(C)Br BNBOUFHCTIFWHN-UHFFFAOYSA-N 0.000 description 1
- GDQTVPUAZAECHX-UHFFFAOYSA-N CC(=O)NCC1CC1 Chemical compound CC(=O)NCC1CC1 GDQTVPUAZAECHX-UHFFFAOYSA-N 0.000 description 1
- KQZCRXVJXGYIFM-UHFFFAOYSA-N CC(=O)NCc1cccnc1 Chemical compound CC(=O)NCc1cccnc1 KQZCRXVJXGYIFM-UHFFFAOYSA-N 0.000 description 1
- IEPKHZOHORIWKU-UHFFFAOYSA-N CC(=O)NCc1nccs1 Chemical compound CC(=O)NCc1nccs1 IEPKHZOHORIWKU-UHFFFAOYSA-N 0.000 description 1
- FBVUSAOLMOZOPB-UHFFFAOYSA-N CC(=O)Nc1cc(C)nc(C)c1 Chemical compound CC(=O)Nc1cc(C)nc(C)c1 FBVUSAOLMOZOPB-UHFFFAOYSA-N 0.000 description 1
- XSNZNZJXEGKLQG-UHFFFAOYSA-N CC(=O)Nc1ccnc(C)c1 Chemical compound CC(=O)Nc1ccnc(C)c1 XSNZNZJXEGKLQG-UHFFFAOYSA-N 0.000 description 1
- BIJAWQUBRNHZGE-UHFFFAOYSA-N CC(=O)Nc1ccncc1 Chemical compound CC(=O)Nc1ccncc1 BIJAWQUBRNHZGE-UHFFFAOYSA-N 0.000 description 1
- DHUDCBCQKIWLSB-UHFFFAOYSA-N CC(=O)Nc1ccncc1C Chemical compound CC(=O)Nc1ccncc1C DHUDCBCQKIWLSB-UHFFFAOYSA-N 0.000 description 1
- WMOVHXAZOJBABW-UHFFFAOYSA-N CC(=O)OC(C)(C)C Chemical compound CC(=O)OC(C)(C)C WMOVHXAZOJBABW-UHFFFAOYSA-N 0.000 description 1
- JVSFQJZRHXAUGT-UHFFFAOYSA-N CC(C)(C)C(=O)Cl Chemical compound CC(C)(C)C(=O)Cl JVSFQJZRHXAUGT-UHFFFAOYSA-N 0.000 description 1
- XRGJNRFHCNZXBS-UHFFFAOYSA-N CC(C)(C)C1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CC(C)NCC(O)CN1CCCN(c2cccc(C(=O)NCc3cccnc3)n2)CC1.CC1(F)CCN(CCCN2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)C1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C#N)n3)CC2)CC1.Cc1ccccc1CNCCCN1CCCN(c2cccc(C(=O)NCC3CC3)n2)CC1.O=C(Nc1ccncc1)c1cccc(N2CCCN(C3CCC(N4CCCC4C(F)(F)F)CC3)CC2)n1.c1cc(-c2ncc(C3CC3)[nH]2)nc(N2CCCN(C3CCC(N4CCCC4)CC3)CC2)c1 Chemical compound CC(C)(C)C1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CC(C)NCC(O)CN1CCCN(c2cccc(C(=O)NCc3cccnc3)n2)CC1.CC1(F)CCN(CCCN2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)C1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C#N)n3)CC2)CC1.Cc1ccccc1CNCCCN1CCCN(c2cccc(C(=O)NCC3CC3)n2)CC1.O=C(Nc1ccncc1)c1cccc(N2CCCN(C3CCC(N4CCCC4C(F)(F)F)CC3)CC2)n1.c1cc(-c2ncc(C3CC3)[nH]2)nc(N2CCCN(C3CCC(N4CCCC4)CC3)CC2)c1 XRGJNRFHCNZXBS-UHFFFAOYSA-N 0.000 description 1
- BUTKIHRNYUEGKB-UHFFFAOYSA-N CC(C)(C)CC(=O)Cl Chemical compound CC(C)(C)CC(=O)Cl BUTKIHRNYUEGKB-UHFFFAOYSA-N 0.000 description 1
- KRUIFYDIUSGGHK-UHFFFAOYSA-N CC(C)(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(CC)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(CF)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCCN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CC4)CC3)CC2)n1 Chemical compound CC(C)(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(CC)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(CF)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCCN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CC4)CC3)CC2)n1 KRUIFYDIUSGGHK-UHFFFAOYSA-N 0.000 description 1
- VCEXADXNECTHNL-JDGJQGBYSA-N CC(C)(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC[C@@H](C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC[C@H](C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.C[C@@H](N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1)C(C)(F)F.C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1)C(C)(F)F.Cc1ccc([C@@H](C)N2CCC(N3CCCN(c4cccc(C(=O)NCC5CC5)n4)CC3)CC2)cc1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN([C@@H]4CCc5ccccc54)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN([C@H]4CCc5ccccc54)CC3)CC2)n1 Chemical compound CC(C)(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC[C@@H](C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC[C@H](C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.C[C@@H](N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1)C(C)(F)F.C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1)C(C)(F)F.Cc1ccc([C@@H](C)N2CCC(N3CCCN(c4cccc(C(=O)NCC5CC5)n4)CC3)CC2)cc1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN([C@@H]4CCc5ccccc54)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN([C@H]4CCc5ccccc54)CC3)CC2)n1 VCEXADXNECTHNL-JDGJQGBYSA-N 0.000 description 1
- FZXJVYPAWUIUHR-UHFFFAOYSA-N CC(C)(C)OC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 Chemical compound CC(C)(C)OC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 FZXJVYPAWUIUHR-UHFFFAOYSA-N 0.000 description 1
- LENAXKZTGZDCEH-UHFFFAOYSA-N CC(C)(C)OC(=O)N1C2=CC(OC)=CC=C2C=C1C1=CC=CC(Cl)=N1 Chemical compound CC(C)(C)OC(=O)N1C2=CC(OC)=CC=C2C=C1C1=CC=CC(Cl)=N1 LENAXKZTGZDCEH-UHFFFAOYSA-N 0.000 description 1
- IISFORCYBPTPGP-UHFFFAOYSA-N CC(C)(C)OC(=O)N1CCC(=O)CC1.CN1CCCN(C2CCNCC2)CC1.CN1CCCNCC1 Chemical compound CC(C)(C)OC(=O)N1CCC(=O)CC1.CN1CCCN(C2CCNCC2)CC1.CN1CCCNCC1 IISFORCYBPTPGP-UHFFFAOYSA-N 0.000 description 1
- TXURECUEAJVTRQ-SFHVURJKSA-N CC(C)(C)OC(=O)N1CCC(C(=O)C[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1 Chemical compound CC(C)(C)OC(=O)N1CCC(C(=O)C[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1 TXURECUEAJVTRQ-SFHVURJKSA-N 0.000 description 1
- AMPJUCZUFLXEDC-UHFFFAOYSA-N CC(C)(C)OC(=O)N1CCC(C(=O)NCCCc2cccc(-c3ncc(C4CC4)[nH]3)n2)C1 Chemical compound CC(C)(C)OC(=O)N1CCC(C(=O)NCCCc2cccc(-c3ncc(C4CC4)[nH]3)n2)C1 AMPJUCZUFLXEDC-UHFFFAOYSA-N 0.000 description 1
- UQQKWSFPSPLYKV-UHFFFAOYSA-N CC(C)(C)OC(=O)N1CCC(NCCCc2cccc(-c3ncc(C4CC4)[nH]3)n2)C1 Chemical compound CC(C)(C)OC(=O)N1CCC(NCCCc2cccc(-c3ncc(C4CC4)[nH]3)n2)C1 UQQKWSFPSPLYKV-UHFFFAOYSA-N 0.000 description 1
- XOISASFSEHWLOH-UHFFFAOYSA-N CC(C)(C)OC(=O)N1CCCC(Cc2cccc(C(=O)Nc3ccncc3)n2)C1 Chemical compound CC(C)(C)OC(=O)N1CCCC(Cc2cccc(C(=O)Nc3ccncc3)n2)C1 XOISASFSEHWLOH-UHFFFAOYSA-N 0.000 description 1
- IOTNEJSHARPCBZ-UHFFFAOYSA-N CC(C)(C)OC(=O)N1CCCC(NCCCc2cccc(-c3ncc(C4CC4)[nH]3)n2)C1 Chemical compound CC(C)(C)OC(=O)N1CCCC(NCCCc2cccc(-c3ncc(C4CC4)[nH]3)n2)C1 IOTNEJSHARPCBZ-UHFFFAOYSA-N 0.000 description 1
- QXHCJEYBORCZJO-UHFFFAOYSA-N CC(C)(C)OC(=O)N1CCCC(NCCCc2cccc(C(=O)Nc3ccncc3)n2)CC1 Chemical compound CC(C)(C)OC(=O)N1CCCC(NCCCc2cccc(C(=O)Nc3ccncc3)n2)CC1 QXHCJEYBORCZJO-UHFFFAOYSA-N 0.000 description 1
- BRZYTDXUGORZGB-UHFFFAOYSA-N CC(C)(C)OC(=O)NCCC(=O)NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1 Chemical compound CC(C)(C)OC(=O)NCCC(=O)NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1 BRZYTDXUGORZGB-UHFFFAOYSA-N 0.000 description 1
- NFNZCGUMLANAGW-IXBBCOTCSA-N CC(C)(C)c1cnc(-c2cccc(N3CCCN(C4CCN(C(C)(C)C)CC4)CC3)n2)[nH]1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(-c5ccccc5)[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C(C)(C)C)[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C(F)(F)F)[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)CC2)CC1.CCc1cnc(-c2cccc(N3CCCN(C4CCN([C@@H](C)C(C)(F)F)CC4)CC3)n2)[nH]1.CCc1cnc(-c2cccc(N3CCCN(C4CCN([C@H](C)CC)CC4)CC3)n2)[nH]1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1C Chemical compound CC(C)(C)c1cnc(-c2cccc(N3CCCN(C4CCN(C(C)(C)C)CC4)CC3)n2)[nH]1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(-c5ccccc5)[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C(C)(C)C)[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C(F)(F)F)[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)CC2)CC1.CCc1cnc(-c2cccc(N3CCCN(C4CCN([C@@H](C)C(C)(F)F)CC4)CC3)n2)[nH]1.CCc1cnc(-c2cccc(N3CCCN(C4CCN([C@H](C)CC)CC4)CC3)n2)[nH]1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1C NFNZCGUMLANAGW-IXBBCOTCSA-N 0.000 description 1
- NNPPMTNAJDCUHE-UHFFFAOYSA-N CC(C)C Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 1
- DGMOBVGABMBZSB-UHFFFAOYSA-N CC(C)C(=O)Cl Chemical compound CC(C)C(=O)Cl DGMOBVGABMBZSB-UHFFFAOYSA-N 0.000 description 1
- CZWPYTKWSFAMLP-UHFFFAOYSA-N CC(C)CN(C)C(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1 Chemical compound CC(C)CN(C)C(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1 CZWPYTKWSFAMLP-UHFFFAOYSA-N 0.000 description 1
- LVFMFFXTSJUNIO-YTQGBOHHSA-N CC(C)CN(C)C(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N4CCc5ccccc54)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N4CCc5ccccc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCN(C)C)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC[C@H]4CCCO4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@@H]4CCOC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@H]4CCOC4)n3)CC2)CC1 Chemical compound CC(C)CN(C)C(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N4CCc5ccccc54)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N4CCc5ccccc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCN(C)C)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC[C@H]4CCCO4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@@H]4CCOC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@H]4CCOC4)n3)CC2)CC1 LVFMFFXTSJUNIO-YTQGBOHHSA-N 0.000 description 1
- WXAVZJBZHHWUMW-UHFFFAOYSA-N CC(C)CNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC4CCOCC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CCOCC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCCn4ccnc4)n3)CC2)CC1.CCCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1 Chemical compound CC(C)CNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC4CCOCC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CCOCC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCCn4ccnc4)n3)CC2)CC1.CCCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.CCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1 WXAVZJBZHHWUMW-UHFFFAOYSA-N 0.000 description 1
- OGWWSAQLSZUOOD-SFHVURJKSA-N CC(C)N1CCC(C(=O)C[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1 Chemical compound CC(C)N1CCC(C(=O)C[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1 OGWWSAQLSZUOOD-SFHVURJKSA-N 0.000 description 1
- AMUSGIXNAJLTGK-UHFFFAOYSA-N CC(C)N1CCC(CC2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(CC2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 AMUSGIXNAJLTGK-UHFFFAOYSA-N 0.000 description 1
- RLYLHLYIUBKNJB-UHFFFAOYSA-N CC(C)N1CCC(CC2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC(C)N1CCC(N2C3CCCC2CN(c2cccc(C(=O)NCC4CC4)n2)CC3)CC1.CC(C)N1CCC(N2CCCC(Oc3cccc(C(=O)Nc4ccncc4)n3)C2)CC1.CC(C)N1CCCC(N2CCC(Oc3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.Cc1ccc(CN2CCC(N3CC4CCC3CN(c3cccc(C(=O)Nc5ccncc5)n3)C4)CC2)c(Cl)c1.Cc1ccccc1CN1CCC(N2C3CCCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)CC3)CC1.O=C(NCC1CC1)c1cccc(N2CCC(CCc3ccccc3Cl)CC2)n1 Chemical compound CC(C)N1CCC(CC2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC(C)N1CCC(N2C3CCCC2CN(c2cccc(C(=O)NCC4CC4)n2)CC3)CC1.CC(C)N1CCC(N2CCCC(Oc3cccc(C(=O)Nc4ccncc4)n3)C2)CC1.CC(C)N1CCCC(N2CCC(Oc3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.Cc1ccc(CN2CCC(N3CC4CCC3CN(c3cccc(C(=O)Nc5ccncc5)n3)C4)CC2)c(Cl)c1.Cc1ccccc1CN1CCC(N2C3CCCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)CC3)CC1.O=C(NCC1CC1)c1cccc(N2CCC(CCc3ccccc3Cl)CC2)n1 RLYLHLYIUBKNJB-UHFFFAOYSA-N 0.000 description 1
- WSXDPJDBHQEBCR-UHFFFAOYSA-N CC(C)N1CCC(CCCCCc2cccc(C(=O)Nc3ccncc3)n2)CC1 Chemical compound CC(C)N1CCC(CCCCCc2cccc(C(=O)Nc3ccncc3)n2)CC1 WSXDPJDBHQEBCR-UHFFFAOYSA-N 0.000 description 1
- DQVLXZQEHCVVPB-HXUWFJFHSA-N CC(C)N1CCC(CC[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1 Chemical compound CC(C)N1CCC(CC[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1 DQVLXZQEHCVVPB-HXUWFJFHSA-N 0.000 description 1
- TZLGHRRJLGVYRT-OYTHEWOJSA-N CC(C)N1CCC(CC[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1.Cc1nc(-c2cccc(N3CC[C@@H](NC[C@@H]4CCN(C5CCCC5)C4)C3)n2)[nH]c1C1CC1.Cc1nc(-c2cccc(N3CC[C@@H](NC[C@@H]4CCN(C5CCCC5)C4)C3)n2)[nH]c1C1CC1.O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCN(C4CCCC4)CC3)C2)n1.O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](NC[C@@H]3CCN(C4CCCC4)C3)C2)n1.O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](NC[C@H]3CCN(C4CCCC4)C3)C2)n1 Chemical compound CC(C)N1CCC(CC[C@@H]2CCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)C2)CC1.Cc1nc(-c2cccc(N3CC[C@@H](NC[C@@H]4CCN(C5CCCC5)C4)C3)n2)[nH]c1C1CC1.Cc1nc(-c2cccc(N3CC[C@@H](NC[C@@H]4CCN(C5CCCC5)C4)C3)n2)[nH]c1C1CC1.O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCN(C4CCCC4)CC3)C2)n1.O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](NC[C@@H]3CCN(C4CCCC4)C3)C2)n1.O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](NC[C@H]3CCN(C4CCCC4)C3)C2)n1 TZLGHRRJLGVYRT-OYTHEWOJSA-N 0.000 description 1
- CTZJXUPNGRWRHB-UHFFFAOYSA-N CC(C)N1CCC(N2CC3CC(C2)N(c2cccc(C(=O)NCC4CC4)n2)C3)CC1.CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)NCC4CC4)n2)C3)CC1.CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)C(F)C1.CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)CC1.Cc1ccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)nc1C(=O)NCC1CC1.Cc1ccccc1CN1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)CC1.c1ccc2c(c1)CCC2N1CCC(N2CCCN(c3nccs3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CC3CC(C2)N(c2cccc(C(=O)NCC4CC4)n2)C3)CC1.CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)NCC4CC4)n2)C3)CC1.CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)C(F)C1.CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)CC1.Cc1ccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)nc1C(=O)NCC1CC1.Cc1ccccc1CN1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)CC1.c1ccc2c(c1)CCC2N1CCC(N2CCCN(c3nccs3)CC2)CC1 CTZJXUPNGRWRHB-UHFFFAOYSA-N 0.000 description 1
- LEVUJAORSZCBJH-UHFFFAOYSA-N CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)NCC4CC4)n2)C3)CC1 Chemical compound CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)NCC4CC4)n2)C3)CC1 LEVUJAORSZCBJH-UHFFFAOYSA-N 0.000 description 1
- MNJMJZUFDKBNSF-UHFFFAOYSA-N CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)C(F)C1 Chemical compound CC(C)N1CCC(N2CC3CCC2CN(c2cccc(C(=O)Nc4ccncc4)n2)C3)C(F)C1 MNJMJZUFDKBNSF-UHFFFAOYSA-N 0.000 description 1
- OURLKORWFRMJTD-UHFFFAOYSA-N CC(C)N1CCC(N2CCC(C)N(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)C(F)C1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2C)CC1.CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CC(O)C2)CC1.CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CCC2C)CC1.CC1=C(c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)CN=C1.CC1CN(c2cccc(C(=O)Nc3ccncc3)n2)CCN(C2CCN(C(C)C)CC2)C1 Chemical compound CC(C)N1CCC(N2CCC(C)N(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)C(F)C1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2C)CC1.CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CC(O)C2)CC1.CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CCC2C)CC1.CC1=C(c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)CN=C1.CC1CN(c2cccc(C(=O)Nc3ccncc3)n2)CCN(C2CCN(C(C)C)CC2)C1 OURLKORWFRMJTD-UHFFFAOYSA-N 0.000 description 1
- FMOCBDQAKSRBNQ-UHFFFAOYSA-N CC(C)N1CCC(N2CCCC(Cc3cccc(C(=O)Nc4ccncc4)n3)C2)CC1 Chemical compound CC(C)N1CCC(N2CCCC(Cc3cccc(C(=O)Nc4ccncc4)n3)C2)CC1 FMOCBDQAKSRBNQ-UHFFFAOYSA-N 0.000 description 1
- DRXRTQBXKCRXMX-CZDDSIDMSA-N CC(C)N1CCC(N2CCCC(Cc3cccc(C(=O)Nc4ccncc4)n3)C2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Cc4ccccc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1C.CC(C)N1CC[C@@H](N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)[C@H](O)C1.CCCC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.Cc1ccc(CN2CCCC(N3CCN(c4cccc(C(=O)Nc5ccncc5)n4)CC3)CC2)c(Cl)c1.Cc1ccccc1CN1CCCC(N2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCC(Cc3cccc(C(=O)Nc4ccncc4)n3)C2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Cc4ccccc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1C.CC(C)N1CC[C@@H](N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)[C@H](O)C1.CCCC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.Cc1ccc(CN2CCCC(N3CCN(c4cccc(C(=O)Nc5ccncc5)n4)CC3)CC2)c(Cl)c1.Cc1ccccc1CN1CCCC(N2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 DRXRTQBXKCRXMX-CZDDSIDMSA-N 0.000 description 1
- VLSYDNSBNKCHJQ-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(Cc3ccccc3)CC2)C(F)C1 Chemical compound CC(C)N1CCC(N2CCCN(Cc3ccccc3)CC2)C(F)C1 VLSYDNSBNKCHJQ-UHFFFAOYSA-N 0.000 description 1
- FOFYJDPAIGOSJG-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4nc(-c5ccccc5)no4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc(C5CC5)no4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nnc(C5CC5)o4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nnn(C)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccccn5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5cccnc5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccncc5)n4)n3)CC2)CC1.CCCCc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)o1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4nc(-c5ccccc5)no4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc(C5CC5)no4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nnc(C5CC5)o4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nnn(C)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccccn5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5cccnc5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccncc5)n4)n3)CC2)CC1.CCCCc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)o1 FOFYJDPAIGOSJG-UHFFFAOYSA-N 0.000 description 1
- WHBJXWCZFCODAF-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cc(F)c(F)cc5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccc(C(F)(F)F)cc5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccc(F)cc5[nH]4)n3)CC2)CC1.Cc1cc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2cc1C.Cc1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1.Cc1cccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c12.[C-]#[N+]c1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cc(F)c(F)cc5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccc(C(F)(F)F)cc5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccc(F)cc5[nH]4)n3)CC2)CC1.Cc1cc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2cc1C.Cc1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1.Cc1cccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c12.[C-]#[N+]c1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1 WHBJXWCZFCODAF-UHFFFAOYSA-N 0.000 description 1
- YGHOCXZFRXXQPL-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccc(C(F)(F)F)cc5[nH]4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccc(C(F)(F)F)cc5[nH]4)n3)CC2)CC1 YGHOCXZFRXXQPL-UHFFFAOYSA-N 0.000 description 1
- XUGRRSMQVDNFQN-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cccc(F)c5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5n4C)n3)CC2)CC1.CCCCNC(=O)c1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.CCNC(=O)c1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCCCn4ccnc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(N)=O)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cccc(F)c5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5[nH]4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5n4C)n3)CC2)CC1.CCCCNC(=O)c1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.CCNC(=O)c1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCCCn4ccnc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(N)=O)n3)CC2)CC1 XUGRRSMQVDNFQN-UHFFFAOYSA-N 0.000 description 1
- YDDNYVJKHNWHEW-UNDSRJPLSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5o4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5s4)n3)CC2)CC1.CCCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.CCCc1nc(-c2cccc(N3CCCN(C4CCN([C@H](C)CC)CC4)CC3)n2)no1.CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.COc1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5o4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5ccccc5s4)n3)CC2)CC1.CCCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.CCCc1nc(-c2cccc(N3CCCN(C4CCN([C@H](C)CC)CC4)CC3)n2)no1.CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.COc1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 YDDNYVJKHNWHEW-UNDSRJPLSA-N 0.000 description 1
- QVYSRAPFUCNKAH-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cnccc5[nH]4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cnccc5[nH]4)n3)CC2)CC1 QVYSRAPFUCNKAH-UHFFFAOYSA-N 0.000 description 1
- SFMBTHSGHJMFFZ-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cnccc5[nH]4)n3)CC2)CC1.CC(C)c1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1.CCCc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1.CCc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1.COc1ccc2c(c1)C=C(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)C2.COc1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2.Cc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4nc5cnccc5[nH]4)n3)CC2)CC1.CC(C)c1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1.CCCc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1.CCc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1.COc1ccc2c(c1)C=C(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)C2.COc1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2.Cc1cnc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]1 SFMBTHSGHJMFFZ-UHFFFAOYSA-N 0.000 description 1
- ZBDJTOUTMWYWHF-WUIWXZTOSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)CC2)C(F)C1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2C)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C(F)C1.CC(C)N1CCN(C)[C@H](CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1.CC(C)N1CCOCC1CCN1CCCN(c2cccc(C(=O)Nc3ccncc3)n2)CC1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4F)CC3)n2)[nH]c1C1CC1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C5CCCC5)CC4F)CC3)n2)[nH]c1C1CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)CC2)C(F)C1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2C)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C(F)C1.CC(C)N1CCN(C)[C@H](CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1.CC(C)N1CCOCC1CCN1CCCN(c2cccc(C(=O)Nc3ccncc3)n2)CC1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4F)CC3)n2)[nH]c1C1CC1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C5CCCC5)CC4F)CC3)n2)[nH]c1C1CC1 ZBDJTOUTMWYWHF-WUIWXZTOSA-N 0.000 description 1
- ZXNWECVWDAUCCO-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4ncc(C5CC5)[nH]4)n3)CC2)CC1 ZXNWECVWDAUCCO-UHFFFAOYSA-N 0.000 description 1
- KFSVYDVWHHNEFK-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccccc5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C(C)(C)C)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C5CC5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C5CCCC5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(CC(C)(C)C)n4)n3)CC2)CC1.CC(C)c1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.CCCCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.COCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccccc5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C(C)(C)C)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C5CC5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C5CCCC5)n4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(CC(C)(C)C)n4)n3)CC2)CC1.CC(C)c1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.CCCCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1.COCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 KFSVYDVWHHNEFK-UHFFFAOYSA-N 0.000 description 1
- DTOIYEKGELGSPX-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccccn5)n4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5ccccn5)n4)n3)CC2)CC1 DTOIYEKGELGSPX-UHFFFAOYSA-N 0.000 description 1
- JOPPUAQVJQEORV-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5cccnc5)n4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(-c5cccnc5)n4)n3)CC2)CC1 JOPPUAQVJQEORV-UHFFFAOYSA-N 0.000 description 1
- MTZXGQSQAHKNIH-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C5CCCC5)n4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(-c4noc(C5CCCC5)n4)n3)CC2)CC1 MTZXGQSQAHKNIH-UHFFFAOYSA-N 0.000 description 1
- PDKLOAGHJKVOJL-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N(C)Cc4cccnc4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N(C)Cc4cccnc4)n3)CC2)CC1 PDKLOAGHJKVOJL-UHFFFAOYSA-N 0.000 description 1
- MCXTVXWHIUGWKX-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N(C)Cc4cccnc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ccccn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ccncc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4cncs4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4nccs4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N(C)Cc4cccnc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ccccn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ccncc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4cncs4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4nccs4)n3)CC2)CC1 MCXTVXWHIUGWKX-UHFFFAOYSA-N 0.000 description 1
- BZNROIDZWGXSRN-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC4CC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(F)(F)F)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(F)F)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCC#N)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCF)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCO)n3)CC2)CC1.COCCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.COCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC4CC4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(F)(F)F)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(F)F)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCC#N)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCF)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCO)n3)CC2)CC1.COCCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.COCCNC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1 BZNROIDZWGXSRN-UHFFFAOYSA-N 0.000 description 1
- DVLHMPJOFFEUTH-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(=O)C4CC4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(=O)C4CC4)n3)CC2)CC1 DVLHMPJOFFEUTH-UHFFFAOYSA-N 0.000 description 1
- PMANISDZPKGFBA-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(F)(F)F)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC(F)(F)F)n3)CC2)CC1 PMANISDZPKGFBA-UHFFFAOYSA-N 0.000 description 1
- ZVOSWMMDUYYPAY-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCO)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCO)n3)CC2)CC1 ZVOSWMMDUYYPAY-UHFFFAOYSA-N 0.000 description 1
- PMBVXXJZONHDMY-YYZCBZSVSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCc4ccccn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCn4ccnc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cnco4)n3)CC2)CC1.COCCNC(=O)c1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC(F)(F)F)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CCOCC4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCCC(C)C)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NC[C@H]4CCCO4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCc4ccccn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCn4ccnc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cnco4)n3)CC2)CC1.COCCNC(=O)c1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC(F)(F)F)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CCOCC4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCCC(C)C)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NC[C@H]4CCCO4)n3)CC2)CC1 PMBVXXJZONHDMY-YYZCBZSVSA-N 0.000 description 1
- JSGYHFUWQXYGGP-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCn4ccnc4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCCn4ccnc4)n3)CC2)CC1 JSGYHFUWQXYGGP-UHFFFAOYSA-N 0.000 description 1
- KXVZNKMMBLOZGS-OAQYLSRUSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC[C@H]4CCCO4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NC[C@H]4CCCO4)n3)CC2)CC1 KXVZNKMMBLOZGS-OAQYLSRUSA-N 0.000 description 1
- OHNJRVQJXVPPQX-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)C(F)C1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)C(F)C1 OHNJRVQJXVPPQX-UHFFFAOYSA-N 0.000 description 1
- LVXIZJYMDYFIBH-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1 LVXIZJYMDYFIBH-UHFFFAOYSA-N 0.000 description 1
- XGUBVYHUYBZIOR-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ccco4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cncs4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cocn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cscn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccn4C)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ncco4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ccco4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cncs4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cocn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cscn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccn4C)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4ncco4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1 XGUBVYHUYBZIOR-UHFFFAOYSA-N 0.000 description 1
- DXTYZVGYSAKYTO-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cnco4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cnco4)n3)CC2)CC1 DXTYZVGYSAKYTO-UHFFFAOYSA-N 0.000 description 1
- HNNFOOUEOBKRGW-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cncs4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cncs4)n3)CC2)CC1 HNNFOOUEOBKRGW-UHFFFAOYSA-N 0.000 description 1
- OIYUFQMJIKMJSD-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1 OIYUFQMJIKMJSD-UHFFFAOYSA-N 0.000 description 1
- SSMWDFGWHHJXGZ-LJQANCHMSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@@H]4CCOC4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@@H]4CCOC4)n3)CC2)CC1 SSMWDFGWHHJXGZ-LJQANCHMSA-N 0.000 description 1
- SSMWDFGWHHJXGZ-IBGZPJMESA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@H]4CCOC4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)N[C@H]4CCOC4)n3)CC2)CC1 SSMWDFGWHHJXGZ-IBGZPJMESA-N 0.000 description 1
- XPEDCBLLXIXRIC-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccc(Cl)cc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccccc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccccc4O)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccccn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4cccnc4)n3)CC2)CC1.COc1ccc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc1.Cc1ccc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccc(Cl)cc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccccc4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccccc4O)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4ccccn4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C(=O)Nc4cccnc4)n3)CC2)CC1.COc1ccc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc1.Cc1ccc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc1 XPEDCBLLXIXRIC-UHFFFAOYSA-N 0.000 description 1
- NDAFCQIPTRUODY-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ccccc54)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ccccc54)n3)CC2)CC1 NDAFCQIPTRUODY-UHFFFAOYSA-N 0.000 description 1
- ZFWUKQHICZUZHV-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ccccc54)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ncccc54)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccccc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cccnc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccncc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cnccc5C4)n3)CC2)CC1.[C-]#[N+]c1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ccccc54)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ncccc54)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccccc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cccnc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccncc5C4)n3)CC2)CC1.CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cnccc5C4)n3)CC2)CC1.[C-]#[N+]c1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2 ZFWUKQHICZUZHV-UHFFFAOYSA-N 0.000 description 1
- DILKMSSGIXTHIV-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ncccc54)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=CCc5ncccc54)n3)CC2)CC1 DILKMSSGIXTHIV-UHFFFAOYSA-N 0.000 description 1
- XEJUCZVCQFSJRO-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccccc5C4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccccc5C4)n3)CC2)CC1 XEJUCZVCQFSJRO-UHFFFAOYSA-N 0.000 description 1
- RXSBBHACYPAVMS-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cccnc5C4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cccnc5C4)n3)CC2)CC1 RXSBBHACYPAVMS-UHFFFAOYSA-N 0.000 description 1
- PUZRJLSMYMGTEP-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccncc5C4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ccncc5C4)n3)CC2)CC1 PUZRJLSMYMGTEP-UHFFFAOYSA-N 0.000 description 1
- BOMNZDNKWNGXAK-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cnccc5C4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5cnccc5C4)n3)CC2)CC1 BOMNZDNKWNGXAK-UHFFFAOYSA-N 0.000 description 1
- MDKJMFXRXAVVJE-UHFFFAOYSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ncccc5C4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ncccc5C4)n3)CC2)CC1 MDKJMFXRXAVVJE-UHFFFAOYSA-N 0.000 description 1
- LABAFSUFIFDHON-VGYFXVRHSA-N CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ncccc5C4)n3)CC2)CC1.CC(CC(C)(F)F)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CC(F)(F)C(C)(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CCCCNC(=O)c1cccc(N2CCCN(C3CCN([C@@H](C)C(C)(F)F)CC3)CC2)n1.C[C@H](N1CCC(N2CCCN(c3cccc(-c4cc5ccccc5n4C)n3)CC2)CC1)C(C)(F)F.C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1)C(C)(F)F.C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1 Chemical compound CC(C)N1CCC(N2CCCN(c3cccc(C4=Cc5ncccc5C4)n3)CC2)CC1.CC(CC(C)(F)F)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CC(F)(F)C(C)(C)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.CCCCNC(=O)c1cccc(N2CCCN(C3CCN([C@@H](C)C(C)(F)F)CC3)CC2)n1.C[C@H](N1CCC(N2CCCN(c3cccc(-c4cc5ccccc5n4C)n3)CC2)CC1)C(C)(F)F.C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1)C(C)(F)F.C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1 LABAFSUFIFDHON-VGYFXVRHSA-N 0.000 description 1
- GETNLHDTKSDDJV-UHFFFAOYSA-N CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CC(O)C2)CC1 Chemical compound CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CC(O)C2)CC1 GETNLHDTKSDDJV-UHFFFAOYSA-N 0.000 description 1
- ATTSDGVAVXAZCZ-UHFFFAOYSA-N CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CCC2C)CC1 Chemical compound CC(C)N1CCC(N2CCN(c3cccc(C(=O)NCC4CC4)n3)CCC2C)CC1 ATTSDGVAVXAZCZ-UHFFFAOYSA-N 0.000 description 1
- IYZXFDWBTGJYBA-UHFFFAOYSA-N CC(C)N1CCCC(N2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 Chemical compound CC(C)N1CCCC(N2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 IYZXFDWBTGJYBA-UHFFFAOYSA-N 0.000 description 1
- RZEYFSJNDOYYMJ-UHFFFAOYSA-N CC(C)N1CCCC(N2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC(C)N1CCOC(CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1.CCCCNC(=O)c1cccc(N2CCCN(CC3CN(C(C)C)CCO3)CC2)n1.Cc1ccc(CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)c(Cl)c1.Cc1nc(-c2cccc(N3CCN(C4CCCN(C(C)C)CC4)CC3)n2)[nH]c1C1CC1.Cc1nc(-c2cccc(N3CCN(C4CCCN(C5CCCC5)CC4)CC3)n2)[nH]c1C1CC1.O=C(NCC1CC1)c1cccc(N2CCCN(CCCN3CCc4ccccc4C3)CC2)n1 Chemical compound CC(C)N1CCCC(N2CCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1.CC(C)N1CCOC(CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1.CCCCNC(=O)c1cccc(N2CCCN(CC3CN(C(C)C)CCO3)CC2)n1.Cc1ccc(CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)c(Cl)c1.Cc1nc(-c2cccc(N3CCN(C4CCCN(C(C)C)CC4)CC3)n2)[nH]c1C1CC1.Cc1nc(-c2cccc(N3CCN(C4CCCN(C5CCCC5)CC4)CC3)n2)[nH]c1C1CC1.O=C(NCC1CC1)c1cccc(N2CCCN(CCCN3CCc4ccccc4C3)CC2)n1 RZEYFSJNDOYYMJ-UHFFFAOYSA-N 0.000 description 1
- HSCUCEAEVDRTDK-UHFFFAOYSA-N CC(C)N1CCCC(NCCCc2cccc(C(=O)Nc3ccncc3)n2)CC1 Chemical compound CC(C)N1CCCC(NCCCc2cccc(C(=O)Nc3ccncc3)n2)CC1 HSCUCEAEVDRTDK-UHFFFAOYSA-N 0.000 description 1
- WVBZMSLWUPRZHZ-JOCHJYFZSA-N CC(C)N1CCN(C)[C@H](CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1 Chemical compound CC(C)N1CCN(C)[C@H](CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1 WVBZMSLWUPRZHZ-JOCHJYFZSA-N 0.000 description 1
- FXRQTMMBLWXLID-UHFFFAOYSA-N CC(C)N1CCOC(CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1 Chemical compound CC(C)N1CCOC(CN2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)C1 FXRQTMMBLWXLID-UHFFFAOYSA-N 0.000 description 1
- DFKOVWGFGBRVEC-UHFFFAOYSA-N CC(C)N1CCOCC1CCN1CCCN(c2cccc(C(=O)Nc3ccncc3)n2)CC1 Chemical compound CC(C)N1CCOCC1CCN1CCCN(c2cccc(C(=O)Nc3ccncc3)n2)CC1 DFKOVWGFGBRVEC-UHFFFAOYSA-N 0.000 description 1
- KHJCULIGROZNMN-NHCUHLMSSA-N CC(C)N1CC[C@@H](N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)[C@H](O)C1 Chemical compound CC(C)N1CC[C@@H](N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)[C@H](O)C1 KHJCULIGROZNMN-NHCUHLMSSA-N 0.000 description 1
- MSVHRBPDBPGZOW-UHFFFAOYSA-N CC(C)c1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 Chemical compound CC(C)c1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 MSVHRBPDBPGZOW-UHFFFAOYSA-N 0.000 description 1
- ISVVKSQOFXWXFP-OVMRATRNSA-N CC(CC(C)(F)F)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CC(F)C(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.COCCN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1)C(C)(F)F.C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CCCC4)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CCCC4F)CC3)CC2)n1 Chemical compound CC(CC(C)(F)F)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CC(F)C(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.CCC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.COCCN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1)C(C)(F)F.C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CCCC4)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CCCC4F)CC3)CC2)n1 ISVVKSQOFXWXFP-OVMRATRNSA-N 0.000 description 1
- SYBQZQAUFSIUIH-UHFFFAOYSA-N CC1=C(c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)CN=C1 Chemical compound CC1=C(c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)CN=C1 SYBQZQAUFSIUIH-UHFFFAOYSA-N 0.000 description 1
- XUKJBAFWRDBCLW-UHFFFAOYSA-N CC1=CCc2ncccc21 Chemical compound CC1=CCc2ncccc21 XUKJBAFWRDBCLW-UHFFFAOYSA-N 0.000 description 1
- YSAXEHWHSLANOM-UHFFFAOYSA-N CC1=Cc2ccccc2C1 Chemical compound CC1=Cc2ccccc2C1 YSAXEHWHSLANOM-UHFFFAOYSA-N 0.000 description 1
- KEOCARXBXOBPHX-UHFFFAOYSA-N CC1=Cc2cccnc2C1 Chemical compound CC1=Cc2cccnc2C1 KEOCARXBXOBPHX-UHFFFAOYSA-N 0.000 description 1
- NEIAWXRELVXBLU-UHFFFAOYSA-N CC1=Cc2ccncc2C1 Chemical compound CC1=Cc2ccncc2C1 NEIAWXRELVXBLU-UHFFFAOYSA-N 0.000 description 1
- YPULUWXRZHLMSZ-UHFFFAOYSA-N CC1=Cc2cnccc2C1 Chemical compound CC1=Cc2cnccc2C1 YPULUWXRZHLMSZ-UHFFFAOYSA-N 0.000 description 1
- WREYREGVWBQXNO-UHFFFAOYSA-N CC1=Cc2ncccc2C1 Chemical compound CC1=Cc2ncccc2C1 WREYREGVWBQXNO-UHFFFAOYSA-N 0.000 description 1
- PCSCFJLGJHWKJL-UHFFFAOYSA-N CC1CCNCCN1 Chemical compound CC1CCNCCN1 PCSCFJLGJHWKJL-UHFFFAOYSA-N 0.000 description 1
- VMJOIXFVKVPLRQ-UHFFFAOYSA-N CC1CNCCNC1 Chemical compound CC1CNCCNC1 VMJOIXFVKVPLRQ-UHFFFAOYSA-N 0.000 description 1
- WRJCIWRNNXEWHC-UHFFFAOYSA-N CCC(=O)C(N)CC Chemical compound CCC(=O)C(N)CC WRJCIWRNNXEWHC-UHFFFAOYSA-N 0.000 description 1
- RZWZRACFZGVKFM-UHFFFAOYSA-N CCC(=O)Cl Chemical compound CCC(=O)Cl RZWZRACFZGVKFM-UHFFFAOYSA-N 0.000 description 1
- QWTDNUCVQCZILF-UHFFFAOYSA-N CCC(C)C Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 description 1
- ALNXLWMJGLCJCX-UHFFFAOYSA-N CCCCC(=O)CN.Cl Chemical compound CCCCC(=O)CN.Cl ALNXLWMJGLCJCX-UHFFFAOYSA-N 0.000 description 1
- XGISHOFUAFNYQF-UHFFFAOYSA-N CCCCC(=O)Cl Chemical compound CCCCC(=O)Cl XGISHOFUAFNYQF-UHFFFAOYSA-N 0.000 description 1
- MBHXJVSJKSOKSZ-UHFFFAOYSA-N CCCc1[nH]c(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)nc1C.CCc1[nH]c(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)nc1C.CCc1cn(C)c(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)n1.CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1C1CC1.CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1CC.COCC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1C1CC1 Chemical compound CCCc1[nH]c(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)nc1C.CCc1[nH]c(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)nc1C.CCc1cn(C)c(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)n1.CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1C1CC1.CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1CC.COCC(C)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.Cc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)[nH]c1C1CC1 MBHXJVSJKSOKSZ-UHFFFAOYSA-N 0.000 description 1
- TWPXTLLVNPZMRW-UHFFFAOYSA-N CCCc1cnc(C)[nH]1 Chemical compound CCCc1cnc(C)[nH]1 TWPXTLLVNPZMRW-UHFFFAOYSA-N 0.000 description 1
- DJJWAJISLKOZIT-MRXNPFEDSA-N CC[C@@H](C)N1CCC(N2CCCN(c3cccc(C(=N)NO)n3)CC2)CC1 Chemical compound CC[C@@H](C)N1CCC(N2CCCN(c3cccc(C(=N)NO)n3)CC2)CC1 DJJWAJISLKOZIT-MRXNPFEDSA-N 0.000 description 1
- GEFNFZTUZOXURZ-UHFFFAOYSA-N CCc1cn(C)c(C)n1 Chemical compound CCc1cn(C)c(C)n1 GEFNFZTUZOXURZ-UHFFFAOYSA-N 0.000 description 1
- AIZFJKZJTGMZNM-UHFFFAOYSA-N CCc1cnc(-c2cccc(CCCN)n2)[nH]1 Chemical compound CCc1cnc(-c2cccc(CCCN)n2)[nH]1 AIZFJKZJTGMZNM-UHFFFAOYSA-N 0.000 description 1
- QVOKLYWBGBUKCJ-QGZVFWFLSA-N CCc1cnc(-c2cccc(CCCNC3CCN([C@H](C)CC)CC3)n2)[nH]1 Chemical compound CCc1cnc(-c2cccc(CCCNC3CCN([C@H](C)CC)CC3)n2)[nH]1 QVOKLYWBGBUKCJ-QGZVFWFLSA-N 0.000 description 1
- GNJZFHKQMSZCEN-UHFFFAOYSA-N CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 Chemical compound CCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 GNJZFHKQMSZCEN-UHFFFAOYSA-N 0.000 description 1
- MOFOVFUQFPPYMJ-UHFFFAOYSA-N CCc1nc(C)[nH]c1CC Chemical compound CCc1nc(C)[nH]c1CC MOFOVFUQFPPYMJ-UHFFFAOYSA-N 0.000 description 1
- NQOXVOAFLKBNNB-UHFFFAOYSA-N CN1CCC(N2CCCN(c3cccc(C(=O)N(C)C)n3)CC2)CC1 Chemical compound CN1CCC(N2CCCN(c3cccc(C(=O)N(C)C)n3)CC2)CC1 NQOXVOAFLKBNNB-UHFFFAOYSA-N 0.000 description 1
- QGYKZMGGICQKHT-UHFFFAOYSA-N CN1CCC(N2CCCN(c3cccc(C(=O)O)n3)CC2)CC1.CNC Chemical compound CN1CCC(N2CCCN(c3cccc(C(=O)O)n3)CC2)CC1.CNC QGYKZMGGICQKHT-UHFFFAOYSA-N 0.000 description 1
- YQWYNMOCRRYVCE-UHFFFAOYSA-N CN1CCCN(C)CC1 Chemical compound CN1CCCN(C)CC1 YQWYNMOCRRYVCE-UHFFFAOYSA-N 0.000 description 1
- LMLGYLLMVBATQO-UHFFFAOYSA-N CN1CCCN(C2CCN(Cc3ccccc3Cl)CC2)CC1.CN1CCCN(C2CCNCC2)CC1.O=Cc1ccccc1Cl Chemical compound CN1CCCN(C2CCN(Cc3ccccc3Cl)CC2)CC1.CN1CCCN(C2CCNCC2)CC1.O=Cc1ccccc1Cl LMLGYLLMVBATQO-UHFFFAOYSA-N 0.000 description 1
- KYFPRQKWIYWXFX-UHFFFAOYSA-N CN1CCN(C)CC1.CNC1CCN(C)C1 Chemical compound CN1CCN(C)CC1.CNC1CCN(C)C1 KYFPRQKWIYWXFX-UHFFFAOYSA-N 0.000 description 1
- LSCYTCMNCWMCQE-UHFFFAOYSA-N CNc1ccncc1 Chemical compound CNc1ccncc1 LSCYTCMNCWMCQE-UHFFFAOYSA-N 0.000 description 1
- JJKWHOSQTYYFAE-UHFFFAOYSA-N COCC(=O)Cl Chemical compound COCC(=O)Cl JJKWHOSQTYYFAE-UHFFFAOYSA-N 0.000 description 1
- AHAQHHNOBHYGCK-UHFFFAOYSA-N COCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 Chemical compound COCc1nc(-c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)no1 AHAQHHNOBHYGCK-UHFFFAOYSA-N 0.000 description 1
- QPKPHXWVOBEGIH-JFHXERIWSA-N COc1ccc(C(=O)NCC2CC2)nc1N1CCCN(C2CCN(Cc3ccccc3C)CC2)CC1.[2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN(C3CCCC3)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN([C@@H](C)C(C)(F)F)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN([C@@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN([C@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound COc1ccc(C(=O)NCC2CC2)nc1N1CCCN(C2CCN(Cc3ccccc3C)CC2)CC1.[2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN(C3CCCC3)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN([C@@H](C)C(C)(F)F)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN([C@@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN([C@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 QPKPHXWVOBEGIH-JFHXERIWSA-N 0.000 description 1
- AGAHETWGCFCMDK-UHFFFAOYSA-N COc1ccc(N)c(N)c1 Chemical compound COc1ccc(N)c(N)c1 AGAHETWGCFCMDK-UHFFFAOYSA-N 0.000 description 1
- ZZFGARRJJYXKGQ-UHFFFAOYSA-N COc1ccc2c(c1)C=C(C)C2 Chemical compound COc1ccc2c(c1)C=C(C)C2 ZZFGARRJJYXKGQ-UHFFFAOYSA-N 0.000 description 1
- RUFNZBDKBCBTCF-UHFFFAOYSA-N COc1ccc2c(c1)C=C(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)C2 Chemical compound COc1ccc2c(c1)C=C(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)C2 RUFNZBDKBCBTCF-UHFFFAOYSA-N 0.000 description 1
- IPVXQQWALPFIMR-UHFFFAOYSA-N COc1ccc2c(c1)CC(C)=C2 Chemical compound COc1ccc2c(c1)CC(C)=C2 IPVXQQWALPFIMR-UHFFFAOYSA-N 0.000 description 1
- LICVBBBFQUDSBA-UHFFFAOYSA-N COc1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2 Chemical compound COc1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2 LICVBBBFQUDSBA-UHFFFAOYSA-N 0.000 description 1
- BCAGGATWIAKGEY-UHFFFAOYSA-N COc1ccc2c(c1)cc(C)n2C(=O)OC(C)(C)C Chemical compound COc1ccc2c(c1)cc(C)n2C(=O)OC(C)(C)C BCAGGATWIAKGEY-UHFFFAOYSA-N 0.000 description 1
- HTUYUWQTHFZGLU-UHFFFAOYSA-N COc1ccc2cc(C)n(C(=O)OC(C)(C)C)c2c1 Chemical compound COc1ccc2cc(C)n(C(=O)OC(C)(C)C)c2c1 HTUYUWQTHFZGLU-UHFFFAOYSA-N 0.000 description 1
- JVCMYJWJGOPXLR-UHFFFAOYSA-N COc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.Cc1ccc(CN2CCC(N3CCCN(c4cccc(C(=O)NCC5CC5)n4)CC3)CC2)c(Cl)c1.Cc1ccc(CN2CCC(N3CCCN(c4cccc(C(=O)NCC5CC5)n4)CC3)CC2)cc1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CCCC4)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(Cc4cccc(Cl)c4)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4)CC3)CC2)n1 Chemical compound COc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.Cc1ccc(CN2CCC(N3CCCN(c4cccc(C(=O)NCC5CC5)n4)CC3)CC2)c(Cl)c1.Cc1ccc(CN2CCC(N3CCCN(c4cccc(C(=O)NCC5CC5)n4)CC3)CC2)cc1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(C4CCCC4)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(Cc4cccc(Cl)c4)CC3)CC2)n1.O=C(NCC1CC1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4)CC3)CC2)n1 JVCMYJWJGOPXLR-UHFFFAOYSA-N 0.000 description 1
- QAGYKUNXZHXKMR-UHFFFAOYSA-N CPD000469186 Natural products CC1=C(O)C=CC=C1C(=O)NC(C(O)CN1C(CC2CCCCC2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-UHFFFAOYSA-N 0.000 description 1
- LUIQWAIBTKXPNX-ZCFIWIBFSA-N C[C@@H](N1CCC(=O)CC1)C(F)(F)F Chemical compound C[C@@H](N1CCC(=O)CC1)C(F)(F)F LUIQWAIBTKXPNX-ZCFIWIBFSA-N 0.000 description 1
- DXKLMRWLVCEOBF-DMAVYMJQSA-N C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1)C(C)(F)F.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc(C)n1.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)ccn1.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(Cc5ccccc5C)CC4)CC3)n2)cc(C)n1.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(Cc5ccccc5C)CC4)CC3)n2)ccn1.Cc1cnccc1NC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.O=C(Nc1ccncc1)c1cccc(N2CCCN(C3CCN(C4CCCC4)CC3)CC2)n1 Chemical compound C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1)C(C)(F)F.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc(C)n1.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)ccn1.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(Cc5ccccc5C)CC4)CC3)n2)cc(C)n1.Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(Cc5ccccc5C)CC4)CC3)n2)ccn1.Cc1cnccc1NC(=O)c1cccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)n1.O=C(Nc1ccncc1)c1cccc(N2CCCN(C3CCN(C4CCCC4)CC3)CC2)n1 DXKLMRWLVCEOBF-DMAVYMJQSA-N 0.000 description 1
- LRJFDHBVNNNIKA-KRWDZBQOSA-N C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1)C(F)(F)F Chemical compound C[C@H](N1CCC(N2CCCN(c3cccc(C(=O)NCc4nccs4)n3)CC2)CC1)C(F)(F)F LRJFDHBVNNNIKA-KRWDZBQOSA-N 0.000 description 1
- GTMJGQSXFUKBIY-JOCHJYFZSA-N C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1 Chemical compound C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCC4CC4)n3)CC2)CC1 GTMJGQSXFUKBIY-JOCHJYFZSA-N 0.000 description 1
- UQHVZVDGWGKQGC-XMMPIXPASA-N C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1 Chemical compound C[C@H](c1ccccc1)N1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1 UQHVZVDGWGKQGC-XMMPIXPASA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- KXJXPVBNKARKFD-UHFFFAOYSA-N Cc1cc(C(=O)NCC2CC2)nc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)c1.Cc1cc(C(=O)NCCCn2ccnc2)nc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)nc1.Cc1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccccc1CN1CCC(N2CCCN(c3cc(C(=O)NCC4CC4)ccn3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(CO)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3ccccn3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3nc(C(=O)NCC4CC4)cs3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3nccs3)CC2)CC1.Cc1ccnc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)c1 Chemical compound Cc1cc(C(=O)NCC2CC2)nc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)c1.Cc1cc(C(=O)NCCCn2ccnc2)nc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)nc1.Cc1cccc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)n1.Cc1ccccc1CN1CCC(N2CCCN(c3cc(C(=O)NCC4CC4)ccn3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(CO)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3ccccn3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3nc(C(=O)NCC4CC4)cs3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3nccs3)CC2)CC1.Cc1ccnc(N2CCCN(C3CCN(Cc4ccccc4C)CC3)CC2)c1 KXJXPVBNKARKFD-UHFFFAOYSA-N 0.000 description 1
- XSZYBMMYQCYIPC-UHFFFAOYSA-N Cc1cc(N)c(N)cc1C Chemical compound Cc1cc(N)c(N)cc1C XSZYBMMYQCYIPC-UHFFFAOYSA-N 0.000 description 1
- CDHRIYRZHZFXQR-UHFFFAOYSA-N Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc(C)n1 Chemical compound Cc1cc(NC(=O)c2cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n2)cc(C)n1 CDHRIYRZHZFXQR-UHFFFAOYSA-N 0.000 description 1
- BJMUOUXGBFNLSN-UHFFFAOYSA-N Cc1cc2ccccc2n1C Chemical compound Cc1cc2ccccc2n1C BJMUOUXGBFNLSN-UHFFFAOYSA-N 0.000 description 1
- KCJPRKHAJSSXBI-UHFFFAOYSA-N Cc1cc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2cc1C Chemical compound Cc1cc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2cc1C KCJPRKHAJSSXBI-UHFFFAOYSA-N 0.000 description 1
- DGRGLKZMKWPMOH-UHFFFAOYSA-N Cc1ccc(N)c(N)c1 Chemical compound Cc1ccc(N)c(N)c1 DGRGLKZMKWPMOH-UHFFFAOYSA-N 0.000 description 1
- LHOSGQSJZFQMKQ-UHFFFAOYSA-N Cc1ccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)nc1C(=O)NCC1CC1 Chemical compound Cc1ccc(N2CCCN(C3CCN(C(C)C)CC3)CC2)nc1C(=O)NCC1CC1 LHOSGQSJZFQMKQ-UHFFFAOYSA-N 0.000 description 1
- AXNUJYHFQHQZBE-UHFFFAOYSA-N Cc1cccc(N)c1N Chemical compound Cc1cccc(N)c1N AXNUJYHFQHQZBE-UHFFFAOYSA-N 0.000 description 1
- SEKGTNRURBBKII-UHFFFAOYSA-N Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NC4CCOCC4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4ccncc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4cocn4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4ncco4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)Nc4cccnc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 Chemical compound Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NC4CCOCC4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4cccnc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4ccncc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4cocn4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)NCc4ncco4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)Nc4cccnc4)n3)CC2)CC1.Cc1ccccc1CN1CCC(N2CCCN(c3cccc(C(=O)Nc4ccncc4)n3)CC2)CC1 SEKGTNRURBBKII-UHFFFAOYSA-N 0.000 description 1
- HBDQEJSFPUINSB-UHFFFAOYSA-N Cc1cn(S(=O)(=O)c2ccccc2)c2ncccc12 Chemical compound Cc1cn(S(=O)(=O)c2ccccc2)c2ncccc12 HBDQEJSFPUINSB-UHFFFAOYSA-N 0.000 description 1
- LLPKQRMDOFYSGZ-UHFFFAOYSA-N Cc1cnc(C)[nH]1 Chemical compound Cc1cnc(C)[nH]1 LLPKQRMDOFYSGZ-UHFFFAOYSA-N 0.000 description 1
- POWGIGAGRCRAOP-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCN)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCN)n2)[nH]c1C1CC1 POWGIGAGRCRAOP-UHFFFAOYSA-N 0.000 description 1
- KWQSYJGQIIPNPO-LJQANCHMSA-N Cc1nc(-c2cccc(CCCNC(=O)[C@@H]3CCN(C4CCCC4)C3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC(=O)[C@@H]3CCN(C4CCCC4)C3)n2)[nH]c1C1CC1 KWQSYJGQIIPNPO-LJQANCHMSA-N 0.000 description 1
- BTPJEUGRHDDDAF-OAHLLOKOSA-N Cc1nc(-c2cccc(CCCNC(=O)[C@@H]3CCNC3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC(=O)[C@@H]3CCNC3)n2)[nH]c1C1CC1 BTPJEUGRHDDDAF-OAHLLOKOSA-N 0.000 description 1
- DVBKFJZUMHMRKJ-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCNC3CCCN(C(=O)OC(C)(C)C)C3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC3CCCN(C(=O)OC(C)(C)C)C3)n2)[nH]c1C1CC1 DVBKFJZUMHMRKJ-UHFFFAOYSA-N 0.000 description 1
- RNGNIXGKLYHCLD-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCNC3CCCN(C(=O)OC(C)(C)C)CC3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC3CCCN(C(=O)OC(C)(C)C)CC3)n2)[nH]c1C1CC1 RNGNIXGKLYHCLD-UHFFFAOYSA-N 0.000 description 1
- QJZYXIJXEIVENT-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCNC3CCCN(C4CCCC4)C3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC3CCCN(C4CCCC4)C3)n2)[nH]c1C1CC1 QJZYXIJXEIVENT-UHFFFAOYSA-N 0.000 description 1
- JTQNXIVNJBNOIZ-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCNC3CCCN(C4CCCC4)CC3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC3CCCN(C4CCCC4)CC3)n2)[nH]c1C1CC1 JTQNXIVNJBNOIZ-UHFFFAOYSA-N 0.000 description 1
- RXPZURYGXYPEAQ-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCNC3CCN(C(=O)OC(C)(C)C)CC3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC3CCN(C(=O)OC(C)(C)C)CC3)n2)[nH]c1C1CC1 RXPZURYGXYPEAQ-UHFFFAOYSA-N 0.000 description 1
- RZMNXRFSJJYHRF-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCNC3CCN(C(C)C)CC3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC3CCN(C(C)C)CC3)n2)[nH]c1C1CC1 RZMNXRFSJJYHRF-UHFFFAOYSA-N 0.000 description 1
- ZPTWOJPZQVWJPJ-UHFFFAOYSA-N Cc1nc(-c2cccc(CCCNC3CCN(C4CCCC4)CC3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC3CCN(C4CCCC4)CC3)n2)[nH]c1C1CC1 ZPTWOJPZQVWJPJ-UHFFFAOYSA-N 0.000 description 1
- WGUKXYCFZSSIMS-IBGZPJMESA-N Cc1nc(-c2cccc(CCCNC[C@@H]3CCN(C4CCCC4)C3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(CCCNC[C@@H]3CCN(C4CCCC4)C3)n2)[nH]c1C1CC1 WGUKXYCFZSSIMS-IBGZPJMESA-N 0.000 description 1
- HFXDJSLSYUZRGM-UHFFFAOYSA-N Cc1nc(-c2cccc(N3CCN(C4CCCN(C(=O)OC(C)(C)C)CC4)CC3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(N3CCN(C4CCCN(C(=O)OC(C)(C)C)CC4)CC3)n2)[nH]c1C1CC1 HFXDJSLSYUZRGM-UHFFFAOYSA-N 0.000 description 1
- LRYVZGVKDOMIKF-OEMAIJDKSA-N Cc1nc(-c2cccc(N3CC[C@@H](NC(=O)C4CCNC4)C3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(N3CC[C@@H](NC(=O)C4CCNC4)C3)n2)[nH]c1C1CC1 LRYVZGVKDOMIKF-OEMAIJDKSA-N 0.000 description 1
- UUCZFULDFFWPQL-VGAJERRHSA-N Cc1nc(-c2cccc(N3CC[C@@H](NCC4CCN(C5CCCC5)C4)C3)n2)[nH]c1C1CC1 Chemical compound Cc1nc(-c2cccc(N3CC[C@@H](NCC4CCN(C5CCCC5)C4)C3)n2)[nH]c1C1CC1 UUCZFULDFFWPQL-VGAJERRHSA-N 0.000 description 1
- JWQVOMJORQXNME-UHFFFAOYSA-N Cc1nc2cnccc2[nH]1 Chemical compound Cc1nc2cnccc2[nH]1 JWQVOMJORQXNME-UHFFFAOYSA-N 0.000 description 1
- IZIAUIRLQYCNAM-UHFFFAOYSA-N Cc1ncc(C(C)(C)C)[nH]1 Chemical compound Cc1ncc(C(C)(C)C)[nH]1 IZIAUIRLQYCNAM-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- GKPXLYNDPNNFJD-UHFFFAOYSA-N Cl.Cl.Cl.CC(C)N1CCC(CC1)N1CC2CCC1CN(C2)c1cccc(n1)C(=O)NCC1CC1 Chemical compound Cl.Cl.Cl.CC(C)N1CCC(CC1)N1CC2CCC1CN(C2)c1cccc(n1)C(=O)NCC1CC1 GKPXLYNDPNNFJD-UHFFFAOYSA-N 0.000 description 1
- KVCVJAIBOQUSJU-UHFFFAOYSA-N Cl.Cl.Cl.O1C(CC)=NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 Chemical compound Cl.Cl.Cl.O1C(CC)=NC(C=2N=C(C=CC=2)N2CCN(CCC2)C2CCN(CC2)C(C)C)=N1 KVCVJAIBOQUSJU-UHFFFAOYSA-N 0.000 description 1
- RWTGUBBBINUODQ-UHFFFAOYSA-N Clc1ccccc1CN1CCC(N2CCCCCC2)CC1 Chemical compound Clc1ccccc1CN1CCC(N2CCCCCC2)CC1 RWTGUBBBINUODQ-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 241001480079 Corymbia calophylla Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine group Chemical group N[C@H](CCCCN)C(=O)O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 description 1
- BWLUMTFWVZZZND-UHFFFAOYSA-N Dibenzylamine Chemical compound C=1C=CC=CC=1CNCC1=CC=CC=C1 BWLUMTFWVZZZND-UHFFFAOYSA-N 0.000 description 1
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- XPOQHMRABVBWPR-UHFFFAOYSA-N Efavirenz Natural products O1C(=O)NC2=CC=C(Cl)C=C2C1(C(F)(F)F)C#CC1CC1 XPOQHMRABVBWPR-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
- XQSPYNMVSIKCOC-NTSWFWBYSA-N Emtricitabine Chemical compound C1=C(F)C(N)=NC(=O)N1[C@H]1O[C@@H](CO)SC1 XQSPYNMVSIKCOC-NTSWFWBYSA-N 0.000 description 1
- 240000001414 Eucalyptus viminalis Species 0.000 description 1
- 102000008016 Eukaryotic Initiation Factor-3 Human genes 0.000 description 1
- 108010089790 Eukaryotic Initiation Factor-3 Proteins 0.000 description 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000001828 Gelatine Substances 0.000 description 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 239000012981 Hank's balanced salt solution Substances 0.000 description 1
- 102100021866 Hepatocyte growth factor Human genes 0.000 description 1
- 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 description 1
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 description 1
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 description 1
- 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 description 1
- 101000617130 Homo sapiens Stromal cell-derived factor 1 Proteins 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
- GRRNUXAQVGOGFE-UHFFFAOYSA-N Hygromycin-B Natural products OC1C(NC)CC(N)C(O)C1OC1C2OC3(C(C(O)C(O)C(C(N)CO)O3)O)OC2C(O)C(CO)O1 GRRNUXAQVGOGFE-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 102100026236 Interleukin-8 Human genes 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 235000006552 Liquidambar styraciflua Nutrition 0.000 description 1
- 206010067125 Liver injury Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 1
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 101100348848 Mus musculus Notch4 gene Proteins 0.000 description 1
- 101100317378 Mus musculus Wnt3 gene Proteins 0.000 description 1
- ZKGNPQKYVKXMGJ-UHFFFAOYSA-N N,N-dimethylacetamide Chemical compound CN(C)C(C)=O.CN(C)C(C)=O ZKGNPQKYVKXMGJ-UHFFFAOYSA-N 0.000 description 1
- ULMHMJAEGZPQRY-UHFFFAOYSA-N N-(tert-butoxycarbonyl)piperidin-2-one Chemical compound CC(C)(C)OC(=O)N1CCCCC1=O ULMHMJAEGZPQRY-UHFFFAOYSA-N 0.000 description 1
- HTLZVHNRZJPSMI-UHFFFAOYSA-N N-ethylpiperidine Chemical compound CCN1CCCCC1 HTLZVHNRZJPSMI-UHFFFAOYSA-N 0.000 description 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
- VXDKFNNSXXSPEP-UHFFFAOYSA-N NCCCCc1cccc(C(=O)Nc2ccncc2)n1 Chemical compound NCCCCc1cccc(C(=O)Nc2ccncc2)n1 VXDKFNNSXXSPEP-UHFFFAOYSA-N 0.000 description 1
- JCJYYFKFSVEWDF-UHFFFAOYSA-N NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1 Chemical compound NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1 JCJYYFKFSVEWDF-UHFFFAOYSA-N 0.000 description 1
- ZAPHENSZTCYETD-UHFFFAOYSA-N NCCCc1cccc(C(=O)Nc2ccncc2)n1 Chemical compound NCCCc1cccc(C(=O)Nc2ccncc2)n1 ZAPHENSZTCYETD-UHFFFAOYSA-N 0.000 description 1
- 239000007832 Na2SO4 Substances 0.000 description 1
- PPWRHKISAQTCCG-UHFFFAOYSA-N Nc1cc(F)c(F)cc1N Chemical compound Nc1cc(F)c(F)cc1N PPWRHKISAQTCCG-UHFFFAOYSA-N 0.000 description 1
- RQWJHUJJBYMJMN-UHFFFAOYSA-N Nc1ccc(C(F)(F)F)cc1N Chemical compound Nc1ccc(C(F)(F)F)cc1N RQWJHUJJBYMJMN-UHFFFAOYSA-N 0.000 description 1
- KWEWNOOZQVJONF-UHFFFAOYSA-N Nc1ccc(F)cc1N Chemical compound Nc1ccc(F)cc1N KWEWNOOZQVJONF-UHFFFAOYSA-N 0.000 description 1
- OJSCBKGRGMBEEW-UHFFFAOYSA-N Nc1cccc(F)c1N Chemical compound Nc1cccc(F)c1N OJSCBKGRGMBEEW-UHFFFAOYSA-N 0.000 description 1
- GEYOCULIXLDCMW-UHFFFAOYSA-N Nc1ccccc1N Chemical compound Nc1ccccc1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- CDAWCLOXVUBKRW-UHFFFAOYSA-N Nc1ccccc1O Chemical compound Nc1ccccc1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 1
- VRVRGVPWCUEOGV-UHFFFAOYSA-N Nc1ccccc1S Chemical compound Nc1ccccc1S VRVRGVPWCUEOGV-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- WEJNAHRBUHLIBS-UHFFFAOYSA-N O=C(CCNC1CCCC1)NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1 Chemical compound O=C(CCNC1CCCC1)NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1 WEJNAHRBUHLIBS-UHFFFAOYSA-N 0.000 description 1
- WEPUZBYKXNKSDH-UHFFFAOYSA-N O=C(Cl)C1CCCC1 Chemical compound O=C(Cl)C1CCCC1 WEPUZBYKXNKSDH-UHFFFAOYSA-N 0.000 description 1
- PASDCCFISLVPSO-UHFFFAOYSA-N O=C(Cl)c1ccccc1 Chemical compound O=C(Cl)c1ccccc1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 description 1
- PSAYJRPASWETSH-UHFFFAOYSA-N O=C(Cl)c1ccccn1 Chemical compound O=C(Cl)c1ccccn1 PSAYJRPASWETSH-UHFFFAOYSA-N 0.000 description 1
- ATBIAJXSKNPHEI-UHFFFAOYSA-N O=C(Cl)c1cccnc1 Chemical compound O=C(Cl)c1cccnc1 ATBIAJXSKNPHEI-UHFFFAOYSA-N 0.000 description 1
- RVQZKNOMKUSGCI-UHFFFAOYSA-N O=C(Cl)c1ccncc1 Chemical compound O=C(Cl)c1ccncc1 RVQZKNOMKUSGCI-UHFFFAOYSA-N 0.000 description 1
- GYNQNYHBEIUYDS-UHFFFAOYSA-N O=C(NCC1CC1)c1cccc(N2CCC(CCc3ccccc3Cl)CC2)n1 Chemical compound O=C(NCC1CC1)c1cccc(N2CCC(CCc3ccccc3Cl)CC2)n1 GYNQNYHBEIUYDS-UHFFFAOYSA-N 0.000 description 1
- ZQIBDHOCRYCYQI-UHFFFAOYSA-N O=C(NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1)C1CCN(C2CCCC2)C1 Chemical compound O=C(NCCCc1cccc(-c2ncc(C3CC3)[nH]2)n1)C1CCN(C2CCCC2)C1 ZQIBDHOCRYCYQI-UHFFFAOYSA-N 0.000 description 1
- NFDXWHNKILIONI-XMMPIXPASA-N O=C(NC[C@H]1CCCO1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4Cl)CC3)CC2)n1 Chemical compound O=C(NC[C@H]1CCCO1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4Cl)CC3)CC2)n1 NFDXWHNKILIONI-XMMPIXPASA-N 0.000 description 1
- COGMOTHICHMETH-UHFFFAOYSA-N O=C(NCc1cocn1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4Cl)CC3)CC2)n1 Chemical compound O=C(NCc1cocn1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4Cl)CC3)CC2)n1 COGMOTHICHMETH-UHFFFAOYSA-N 0.000 description 1
- DJJHFOJAWLQWDW-UHFFFAOYSA-N O=C(Nc1cccnc1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4Cl)CC3)CC2)n1 Chemical compound O=C(Nc1cccnc1)c1cccc(N2CCCN(C3CCN(Cc4ccccc4Cl)CC3)CC2)n1 DJJHFOJAWLQWDW-UHFFFAOYSA-N 0.000 description 1
- OYDMJHASCMRDIK-UHFFFAOYSA-N O=C(Nc1ccncc1)c1cccc(N2CC3CCC(C2)N(C2CCN(Cc4ccc(F)cc4Cl)CC2)C3)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CC3CCC(C2)N(C2CCN(Cc4ccc(F)cc4Cl)CC2)C3)n1 OYDMJHASCMRDIK-UHFFFAOYSA-N 0.000 description 1
- XCOLARHLZAAWQV-UHFFFAOYSA-N O=C(Nc1ccncc1)c1cccc(N2CCC3CCCC(C2)N3)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CCC3CCCC(C2)N3)n1 XCOLARHLZAAWQV-UHFFFAOYSA-N 0.000 description 1
- GVPLHARDFXTCST-UHFFFAOYSA-N O=C(Nc1ccncc1)c1cccc(N2CCCN(C3CCC(N4CCCC4C(F)(F)F)CC3)CC2)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CCCN(C3CCC(N4CCCC4C(F)(F)F)CC3)CC2)n1 GVPLHARDFXTCST-UHFFFAOYSA-N 0.000 description 1
- GEFULGZZZIHERY-UHFFFAOYSA-N O=C(Nc1ccncc1)c1cccc(N2CCN(C3CCCNCC3)CC2)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CCN(C3CCCNCC3)CC2)n1 GEFULGZZZIHERY-UHFFFAOYSA-N 0.000 description 1
- GLNLDGDZSWSCHL-JOCHJYFZSA-N O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCN(C4CCCC4)CC3)C2)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCN(C4CCCC4)CC3)C2)n1 GLNLDGDZSWSCHL-JOCHJYFZSA-N 0.000 description 1
- QQGMQJSNKPYVKG-ZYMOGRSISA-N O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCNC3)C2)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCNC3)C2)n1 QQGMQJSNKPYVKG-ZYMOGRSISA-N 0.000 description 1
- RCBNRYXONFEYCP-GOSISDBHSA-N O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCNCC3)C2)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CCC3CCNCC3)C2)n1 RCBNRYXONFEYCP-GOSISDBHSA-N 0.000 description 1
- QQGMQJSNKPYVKG-DLBZAZTESA-N O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CC[C@H]3CCNC3)C2)n1 Chemical compound O=C(Nc1ccncc1)c1cccc(N2CC[C@@H](CC[C@H]3CCNC3)C2)n1 QQGMQJSNKPYVKG-DLBZAZTESA-N 0.000 description 1
- QWKMIJLSWJYLDZ-CQSZACIVSA-N O=C1CCN([C@@H]2CCc3ccccc32)CC1 Chemical compound O=C1CCN([C@@H]2CCc3ccccc32)CC1 QWKMIJLSWJYLDZ-CQSZACIVSA-N 0.000 description 1
- SJLSQITZGUTOMN-UHFFFAOYSA-N OC1CNCCNC1 Chemical compound OC1CNCCNC1 SJLSQITZGUTOMN-UHFFFAOYSA-N 0.000 description 1
- 229910019213 POCl3 Inorganic materials 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical class [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 1
- 201000007737 Retinal degeneration Diseases 0.000 description 1
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000872198 Serjania polyphylla Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 102100021669 Stromal cell-derived factor 1 Human genes 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
- OKJPEAGHQZHRQV-UHFFFAOYSA-N Triiodomethane Natural products IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 description 1
- DRBGBNITLJVDLD-ZELGOLJFSA-N [2H]C1([2H])CCC(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccc(C)cc2Cl)CC1.[2H]C1([2H])CCC(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccccc2C)CC1.[2H]C1([2H])CCN(C2CCN(C(C)C)CC2F)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN(Cc3ccc(F)cc3C)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCC(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccc(C)cc2Cl)CC1.[2H]C1([2H])CCC(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccccc2C)CC1.[2H]C1([2H])CCN(C2CCN(C(C)C)CC2F)CCN1c1cccc(C(=O)Nc2ccncc2)n1.[2H]C1([2H])CCN(C2CCN(Cc3ccc(F)cc3C)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 DRBGBNITLJVDLD-ZELGOLJFSA-N 0.000 description 1
- JOJPSTDQYMIMII-XUWBISKJSA-N [2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)NCC2CC2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)NCC2CC2)n1 JOJPSTDQYMIMII-XUWBISKJSA-N 0.000 description 1
- OLSCUAOTRUXBBD-MFLWLIQGSA-N [2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)NCC2CC2)n1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1F.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)C(C)(F)F)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)CC)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@H](C)CC)CC1 Chemical compound [2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)NCC2CC2)n1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1F.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)C(C)(F)F)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)CC)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@H](C)CC)CC1 OLSCUAOTRUXBBD-MFLWLIQGSA-N 0.000 description 1
- XNUNVQKARNSSEO-FNHLFAINSA-N [2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN(C(C)C)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 XNUNVQKARNSSEO-FNHLFAINSA-N 0.000 description 1
- WTEAYVHVICAIEE-KLTYLHELSA-N [2H]C1([2H])CCN(C2CCN(C(C)C)CC2F)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN(C(C)C)CC2F)CCN1c1cccc(C(=O)Nc2ccncc2)n1 WTEAYVHVICAIEE-KLTYLHELSA-N 0.000 description 1
- PJIDOYNGVYOOIW-BPPAMHLBSA-N [2H]C1([2H])CCN(C2CCN(C3CCCC3)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN(C3CCCC3)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 PJIDOYNGVYOOIW-BPPAMHLBSA-N 0.000 description 1
- MPOCAUOCMSZBJA-FNHLFAINSA-N [2H]C1([2H])CCN(C2CCN(Cc3ccc(F)cc3Cl)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN(Cc3ccc(F)cc3Cl)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 MPOCAUOCMSZBJA-FNHLFAINSA-N 0.000 description 1
- QZKSGLWOOAMJLA-BPPAMHLBSA-N [2H]C1([2H])CCN(C2CCN(Cc3ccccc3Cl)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN(Cc3ccccc3Cl)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 QZKSGLWOOAMJLA-BPPAMHLBSA-N 0.000 description 1
- DVUKLQKJKISLSU-TULHMLFLSA-N [2H]C1([2H])CCN(C2CCN([C@@H](C)C(F)(F)F)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN([C@@H](C)C(F)(F)F)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 DVUKLQKJKISLSU-TULHMLFLSA-N 0.000 description 1
- XDLFGYFJWAMRJF-BATAXFKFSA-N [2H]C1([2H])CCN(C2CCN([C@@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN([C@@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 XDLFGYFJWAMRJF-BATAXFKFSA-N 0.000 description 1
- XDLFGYFJWAMRJF-FSYUUTBDSA-N [2H]C1([2H])CCN(C2CCN([C@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCN([C@H](C)CC)CC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 XDLFGYFJWAMRJF-FSYUUTBDSA-N 0.000 description 1
- IYEDGYZURPOKTH-FNHLFAINSA-N [2H]C1([2H])CCN(C2CCNCC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCNCC2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 IYEDGYZURPOKTH-FNHLFAINSA-N 0.000 description 1
- ZTGSYSRKOAXVIX-XUWBISKJSA-N [2H]C1([2H])CCN(C2CCNCC2F)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(C2CCNCC2F)CCN1c1cccc(C(=O)Nc2ccncc2)n1 ZTGSYSRKOAXVIX-XUWBISKJSA-N 0.000 description 1
- NGECKXKOOXAGCQ-MGVXTIMCSA-N [2H]C1([2H])CCN(Cc2ccccc2)CC(C)N1 Chemical compound [2H]C1([2H])CCN(Cc2ccccc2)CC(C)N1 NGECKXKOOXAGCQ-MGVXTIMCSA-N 0.000 description 1
- JTJTYCPQUOROFM-RJSZUWSASA-N [2H]C1([2H])CCN(Cc2ccccc2)CCN1 Chemical compound [2H]C1([2H])CCN(Cc2ccccc2)CCN1 JTJTYCPQUOROFM-RJSZUWSASA-N 0.000 description 1
- MHGRLBWFKFHHQW-XUWBISKJSA-N [2H]C1([2H])CCN(Cc2ccccc2)CCN1C1CCN(C(=O)OC(C)(C)C)CC1F Chemical compound [2H]C1([2H])CCN(Cc2ccccc2)CCN1C1CCN(C(=O)OC(C)(C)C)CC1F MHGRLBWFKFHHQW-XUWBISKJSA-N 0.000 description 1
- VLSYDNSBNKCHJQ-ZWGOZCLVSA-N [2H]C1([2H])CCN(Cc2ccccc2)CCN1C1CCN(C(C)C)CC1F Chemical compound [2H]C1([2H])CCN(Cc2ccccc2)CCN1C1CCN(C(C)C)CC1F VLSYDNSBNKCHJQ-ZWGOZCLVSA-N 0.000 description 1
- SOCXBOKCAHUNNQ-KLTYLHELSA-N [2H]C1([2H])CCN(Cc2ccccc2)CCN1c1cccc(C(=O)NCC2CC2)n1 Chemical compound [2H]C1([2H])CCN(Cc2ccccc2)CCN1c1cccc(C(=O)NCC2CC2)n1 SOCXBOKCAHUNNQ-KLTYLHELSA-N 0.000 description 1
- SELAWHFWNVHQKR-DOBBINOXSA-N [2H]C1([2H])CCN(Cc2ccccc2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCN(Cc2ccccc2)CCN1c1cccc(C(=O)Nc2ccncc2)n1 SELAWHFWNVHQKR-DOBBINOXSA-N 0.000 description 1
- JOJPSTDQYMIMII-ZWGOZCLVSA-N [2H]C1([2H])CCN(c2cccc(C(=O)NCC3CC3)n2)CCN1C1CCN(C(C)C)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)NCC3CC3)n2)CCN1C1CCN(C(C)C)CC1 JOJPSTDQYMIMII-ZWGOZCLVSA-N 0.000 description 1
- ADATYJAWVSQMDB-JVJRUEKCSA-N [2H]C1([2H])CCN(c2cccc(C(=O)NCC3CC3)n2)CCN1C1CCN(C(C)C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN([C@@H](C)C(C)(F)F)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C2CCCC2)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccc(F)cc2C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccccc2C)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)NCC3CC3)n2)CCN1C1CCN(C(C)C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN([C@@H](C)C(C)(F)F)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C2CCCC2)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccc(F)cc2C)CC1.[2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccccc2C)CC1 ADATYJAWVSQMDB-JVJRUEKCSA-N 0.000 description 1
- BRIAMUHVIWOGTF-DOBBINOXSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(C(C)C)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(C(C)C)CC1 BRIAMUHVIWOGTF-DOBBINOXSA-N 0.000 description 1
- PASLZRPFLLITPJ-DOBBINOXSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccc(F)cc2Cl)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccc(F)cc2Cl)CC1 PASLZRPFLLITPJ-DOBBINOXSA-N 0.000 description 1
- VCPHBTPEBOTHGZ-FBCWWBABSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccccc2Cl)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN(Cc2ccccc2Cl)CC1 VCPHBTPEBOTHGZ-FBCWWBABSA-N 0.000 description 1
- LOSKSFBCAPGZON-YTGUYQJHSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN([C@@H](C)C(F)(F)F)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCN([C@@H](C)C(F)(F)F)CC1 LOSKSFBCAPGZON-YTGUYQJHSA-N 0.000 description 1
- RIIWQWDDZDSNMM-DOBBINOXSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCNCC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CC(C)N1C1CCNCC1 RIIWQWDDZDSNMM-DOBBINOXSA-N 0.000 description 1
- XNUNVQKARNSSEO-KLTYLHELSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1 XNUNVQKARNSSEO-KLTYLHELSA-N 0.000 description 1
- WTEAYVHVICAIEE-XUWBISKJSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1F Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C(C)C)CC1F WTEAYVHVICAIEE-XUWBISKJSA-N 0.000 description 1
- PJIDOYNGVYOOIW-DOBBINOXSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C2CCCC2)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(C2CCCC2)CC1 PJIDOYNGVYOOIW-DOBBINOXSA-N 0.000 description 1
- MPOCAUOCMSZBJA-KLTYLHELSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccc(F)cc2Cl)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccc(F)cc2Cl)CC1 MPOCAUOCMSZBJA-KLTYLHELSA-N 0.000 description 1
- QZKSGLWOOAMJLA-DOBBINOXSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccccc2Cl)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN(Cc2ccccc2Cl)CC1 QZKSGLWOOAMJLA-DOBBINOXSA-N 0.000 description 1
- DVUKLQKJKISLSU-JJRSTHBFSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)C(F)(F)F)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)C(F)(F)F)CC1 DVUKLQKJKISLSU-JJRSTHBFSA-N 0.000 description 1
- XDLFGYFJWAMRJF-ANSDHCKWSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)CC)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@@H](C)CC)CC1 XDLFGYFJWAMRJF-ANSDHCKWSA-N 0.000 description 1
- XDLFGYFJWAMRJF-FRLUAKGISA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@H](C)CC)CC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCN([C@H](C)CC)CC1 XDLFGYFJWAMRJF-FRLUAKGISA-N 0.000 description 1
- IYEDGYZURPOKTH-KLTYLHELSA-N [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCNCC1 Chemical compound [2H]C1([2H])CCN(c2cccc(C(=O)Nc3ccncc3)n2)CCN1C1CCNCC1 IYEDGYZURPOKTH-KLTYLHELSA-N 0.000 description 1
- NVDVEUVZQNWXNY-KNXIQCGSSA-N [2H]C1([2H])CCNCC(C)N1C1CCN(C(=O)OC(C)(C)C)CC1 Chemical compound [2H]C1([2H])CCNCC(C)N1C1CCN(C(=O)OC(C)(C)C)CC1 NVDVEUVZQNWXNY-KNXIQCGSSA-N 0.000 description 1
- LBAKOCZGMFOEHV-MGVXTIMCSA-N [2H]C1([2H])CCNCC(C)N1C1CCN(C(C)C)CC1 Chemical compound [2H]C1([2H])CCNCC(C)N1C1CCN(C(C)C)CC1 LBAKOCZGMFOEHV-MGVXTIMCSA-N 0.000 description 1
- BROWFZOUZVUGNX-QFMPYKMNSA-N [2H]C1([2H])CCNCC(C)N1C1CCN([C@@H](C)C(F)(F)F)CC1 Chemical compound [2H]C1([2H])CCNCC(C)N1C1CCN([C@@H](C)C(F)(F)F)CC1 BROWFZOUZVUGNX-QFMPYKMNSA-N 0.000 description 1
- AMNOQTRJYBJQJM-KNXIQCGSSA-N [2H]C1([2H])CCNCCN1C1CCN(C(=O)OC(C)(C)C)CC1 Chemical compound [2H]C1([2H])CCNCCN1C1CCN(C(=O)OC(C)(C)C)CC1 AMNOQTRJYBJQJM-KNXIQCGSSA-N 0.000 description 1
- FZXCGEZLFRJDIM-MGVXTIMCSA-N [2H]C1([2H])CCNCCN1C1CCN(C(C)C)CC1 Chemical compound [2H]C1([2H])CCNCCN1C1CCN(C(C)C)CC1 FZXCGEZLFRJDIM-MGVXTIMCSA-N 0.000 description 1
- OWFKKIWJZOAEQE-RJSZUWSASA-N [2H]C1([2H])CCNCCN1C1CCN(C(C)C)CC1F Chemical compound [2H]C1([2H])CCNCCN1C1CCN(C(C)C)CC1F OWFKKIWJZOAEQE-RJSZUWSASA-N 0.000 description 1
- XKJSWQOXONLJDD-KBMKNGFXSA-N [2H]C1([2H])CCNCCN1C1CCN(C2CCCC2)CC1 Chemical compound [2H]C1([2H])CCNCCN1C1CCN(C2CCCC2)CC1 XKJSWQOXONLJDD-KBMKNGFXSA-N 0.000 description 1
- RVLRNTQGSLLSJF-JIMJZVQFSA-N [2H]C1([2H])CCNCCN1C1CCN([C@@H](C)C(F)(F)F)CC1 Chemical compound [2H]C1([2H])CCNCCN1C1CCN([C@@H](C)C(F)(F)F)CC1 RVLRNTQGSLLSJF-JIMJZVQFSA-N 0.000 description 1
- GOJDFIIBVTUTGB-AVKLXLHRSA-N [2H]C1([2H])CCNCCN1C1CCN([C@@H](C)CC)CC1 Chemical compound [2H]C1([2H])CCNCCN1C1CCN([C@@H](C)CC)CC1 GOJDFIIBVTUTGB-AVKLXLHRSA-N 0.000 description 1
- GOJDFIIBVTUTGB-RMCHSGAYSA-N [2H]C1([2H])CCNCCN1C1CCN([C@H](C)CC)CC1 Chemical compound [2H]C1([2H])CCNCCN1C1CCN([C@H](C)CC)CC1 GOJDFIIBVTUTGB-RMCHSGAYSA-N 0.000 description 1
- JROKBBVMJQNVNA-KNXIQCGSSA-N [2H]C1([2H])CCNCCN1c1cccc(C(=O)NCC2CC2)n1 Chemical compound [2H]C1([2H])CCNCCN1c1cccc(C(=O)NCC2CC2)n1 JROKBBVMJQNVNA-KNXIQCGSSA-N 0.000 description 1
- FULCQLXILFPZHU-ZWGOZCLVSA-N [2H]C1([2H])CCNCCN1c1cccc(C(=O)Nc2ccncc2)n1 Chemical compound [2H]C1([2H])CCNCCN1c1cccc(C(=O)Nc2ccncc2)n1 FULCQLXILFPZHU-ZWGOZCLVSA-N 0.000 description 1
- FFIPWPORLCSRPF-UHFFFAOYSA-N [C-]#[N+]c1ccc(N)c(N)c1 Chemical compound [C-]#[N+]c1ccc(N)c(N)c1 FFIPWPORLCSRPF-UHFFFAOYSA-N 0.000 description 1
- FZUAYTMUUZWVRK-UHFFFAOYSA-N [C-]#[N+]c1ccc2c(c1)CC(C)=C2 Chemical compound [C-]#[N+]c1ccc2c(c1)CC(C)=C2 FZUAYTMUUZWVRK-UHFFFAOYSA-N 0.000 description 1
- KSMXFMFOTKDXAC-UHFFFAOYSA-N [C-]#[N+]c1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2 Chemical compound [C-]#[N+]c1ccc2c(c1)CC(c1cccc(N3CCCN(C4CCN(C(C)C)CC4)CC3)n1)=C2 KSMXFMFOTKDXAC-UHFFFAOYSA-N 0.000 description 1
- YTLIQCFCJHRREG-UHFFFAOYSA-N [C-]#[N+]c1ccc2cc(C)n(C(=O)OC(C)(C)C)c2c1 Chemical compound [C-]#[N+]c1ccc2cc(C)n(C(=O)OC(C)(C)C)c2c1 YTLIQCFCJHRREG-UHFFFAOYSA-N 0.000 description 1
- HJFFNNWJQNLLBD-UHFFFAOYSA-N [C-]#[N+]c1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1 Chemical compound [C-]#[N+]c1ccc2nc(-c3cccc(N4CCCN(C5CCN(C(C)C)CC5)CC4)n3)[nH]c2c1 HJFFNNWJQNLLBD-UHFFFAOYSA-N 0.000 description 1
- 229960004748 abacavir Drugs 0.000 description 1
- MCGSCOLBFJQGHM-SCZZXKLOSA-N abacavir Chemical compound C=12N=CN([C@H]3C=C[C@@H](CO)C3)C2=NC(N)=NC=1NC1CC1 MCGSCOLBFJQGHM-SCZZXKLOSA-N 0.000 description 1
- QOMNQGZXFYNBNG-UHFFFAOYSA-N acetyloxymethyl 2-[2-[2-[5-[3-(acetyloxymethoxy)-2,7-difluoro-6-oxoxanthen-9-yl]-2-[bis[2-(acetyloxymethoxy)-2-oxoethyl]amino]phenoxy]ethoxy]-n-[2-(acetyloxymethoxy)-2-oxoethyl]-4-methylanilino]acetate Chemical compound CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)C1=CC=C(C)C=C1OCCOC1=CC(C2=C3C=C(F)C(=O)C=C3OC3=CC(OCOC(C)=O)=C(F)C=C32)=CC=C1N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O QOMNQGZXFYNBNG-UHFFFAOYSA-N 0.000 description 1
- 229960004150 aciclovir Drugs 0.000 description 1
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001263 acyl chlorides Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229960001997 adefovir Drugs 0.000 description 1
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000003282 alkyl amino group Chemical group 0.000 description 1
- 238000011316 allogeneic transplantation Methods 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 238000010640 amide synthesis reaction Methods 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- OYTKINVCDFNREN-UHFFFAOYSA-N amifampridine Chemical compound NC1=CC=NC=C1N OYTKINVCDFNREN-UHFFFAOYSA-N 0.000 description 1
- 229960004012 amifampridine Drugs 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 229960001830 amprenavir Drugs 0.000 description 1
- YMARZQAQMVYCKC-OEMFJLHTSA-N amprenavir Chemical compound C([C@@H]([C@H](O)CN(CC(C)C)S(=O)(=O)C=1C=CC(N)=CC=1)NC(=O)O[C@@H]1COCC1)C1=CC=CC=C1 YMARZQAQMVYCKC-OEMFJLHTSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000001772 anti-angiogenic effect Effects 0.000 description 1
- 230000003556 anti-epileptic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 238000011225 antiretroviral therapy Methods 0.000 description 1
- 229940124522 antiretrovirals Drugs 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 229940121357 antivirals Drugs 0.000 description 1
- 238000011914 asymmetric synthesis Methods 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000007844 axonal damage Effects 0.000 description 1
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- MXOQNVMDKHLYCZ-UHFFFAOYSA-N benzamidoxime Chemical compound ON=C(N)C1=CC=CC=C1 MXOQNVMDKHLYCZ-UHFFFAOYSA-N 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 1
- GDPSCBPOCONUDM-LBPRGKRZSA-N benzyl (3s)-3-formylpyrrolidine-1-carboxylate Chemical compound C1[C@@H](C=O)CCN1C(=O)OCC1=CC=CC=C1 GDPSCBPOCONUDM-LBPRGKRZSA-N 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 238000004820 blood count Methods 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910000085 borane Inorganic materials 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- OOTZWFLIDUYXEP-UHFFFAOYSA-N c1cc(CCCNC2CCCN(C3CCCC3)C2)nc(-c2ncc(C3CC3)[nH]2)c1 Chemical compound c1cc(CCCNC2CCCN(C3CCCC3)C2)nc(-c2ncc(C3CC3)[nH]2)c1 OOTZWFLIDUYXEP-UHFFFAOYSA-N 0.000 description 1
- RCKQSMUXKHZEGH-UHFFFAOYSA-N c1cc(CCCNC2CCN(C3CCCC3)C2)nc(-c2ncc(C3CC3)[nH]2)c1 Chemical compound c1cc(CCCNC2CCN(C3CCCC3)C2)nc(-c2ncc(C3CC3)[nH]2)c1 RCKQSMUXKHZEGH-UHFFFAOYSA-N 0.000 description 1
- HWIUZWPYIYQQME-UHFFFAOYSA-N c1cc(CCCNCC2CCN(C3CCCC3)C2)nc(-c2ncc(C3CC3)[nH]2)c1 Chemical compound c1cc(CCCNCC2CCN(C3CCCC3)C2)nc(-c2ncc(C3CC3)[nH]2)c1 HWIUZWPYIYQQME-UHFFFAOYSA-N 0.000 description 1
- XCENYYGSQNTQDS-UHFFFAOYSA-N c1cc(CCCNCCCNC2CCCC2)nc(-c2ncc(C3CC3)[nH]2)c1 Chemical compound c1cc(CCCNCCCNC2CCCC2)nc(-c2ncc(C3CC3)[nH]2)c1 XCENYYGSQNTQDS-UHFFFAOYSA-N 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- DGLFSNZWRYADFC-UHFFFAOYSA-N chembl2334586 Chemical compound C1CCC2=CN=C(N)N=C2C2=C1NC1=CC=C(C#CC(C)(O)C)C=C12 DGLFSNZWRYADFC-UHFFFAOYSA-N 0.000 description 1
- 125000003636 chemical group Chemical group 0.000 description 1
- 230000003399 chemotactic effect Effects 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000003021 clonogenic effect Effects 0.000 description 1
- 230000019771 cognition Effects 0.000 description 1
- 230000001332 colony forming effect Effects 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- WZHCOOQXZCIUNC-UHFFFAOYSA-N cyclandelate Chemical class C1C(C)(C)CC(C)CC1OC(=O)C(O)C1=CC=CC=C1 WZHCOOQXZCIUNC-UHFFFAOYSA-N 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- YKFKEYKJGVSEIX-UHFFFAOYSA-N cyclohexanone, 4-(1,1-dimethylethyl)- Chemical compound CC(C)(C)C1CCC(=O)CC1 YKFKEYKJGVSEIX-UHFFFAOYSA-N 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- JFYKIEHOOZWARC-UHFFFAOYSA-N cyclopropanecarbohydrazide Chemical compound NNC(=O)C1CC1 JFYKIEHOOZWARC-UHFFFAOYSA-N 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- DEZRYPDIMOWBDS-UHFFFAOYSA-N dcm dichloromethane Chemical compound ClCCl.ClCCl DEZRYPDIMOWBDS-UHFFFAOYSA-N 0.000 description 1
- 238000006264 debenzylation reaction Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229960002656 didanosine Drugs 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- ZHXTWWCDMUWMDI-UHFFFAOYSA-N dihydroxyboron Chemical compound O[B]O ZHXTWWCDMUWMDI-UHFFFAOYSA-N 0.000 description 1
- UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical compound CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 description 1
- FGRVOLIFQGXPCT-UHFFFAOYSA-L dipotassium;dioxido-oxo-sulfanylidene-$l^{6}-sulfane Chemical compound [K+].[K+].[O-]S([O-])(=O)=S FGRVOLIFQGXPCT-UHFFFAOYSA-L 0.000 description 1
- UZZWBUYVTBPQIV-UHFFFAOYSA-N dme dimethoxyethane Chemical compound COCCOC.COCCOC UZZWBUYVTBPQIV-UHFFFAOYSA-N 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical class CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000000890 drug combination Substances 0.000 description 1
- 229960002866 duloxetine Drugs 0.000 description 1
- 229960003804 efavirenz Drugs 0.000 description 1
- XPOQHMRABVBWPR-ZDUSSCGKSA-N efavirenz Chemical compound C([C@]1(C2=CC(Cl)=CC=C2NC(=O)O1)C(F)(F)F)#CC1CC1 XPOQHMRABVBWPR-ZDUSSCGKSA-N 0.000 description 1
- 238000000132 electrospray ionisation Methods 0.000 description 1
- 229960000366 emtricitabine Drugs 0.000 description 1
- 239000006274 endogenous ligand Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- OLAMWIPURJGSKE-UHFFFAOYSA-N et2o diethylether Chemical compound CCOCC.CCOCC OLAMWIPURJGSKE-UHFFFAOYSA-N 0.000 description 1
- LHWWETDBWVTKJO-UHFFFAOYSA-N et3n triethylamine Chemical compound CCN(CC)CC.CCN(CC)CC LHWWETDBWVTKJO-UHFFFAOYSA-N 0.000 description 1
- OCLXJTCGWSSVOE-UHFFFAOYSA-N ethanol etoh Chemical compound CCO.CCO OCLXJTCGWSSVOE-UHFFFAOYSA-N 0.000 description 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
- 229940093471 ethyl oleate Drugs 0.000 description 1
- OJCSPXHYDFONPU-UHFFFAOYSA-N etoac etoac Chemical compound CCOC(C)=O.CCOC(C)=O OJCSPXHYDFONPU-UHFFFAOYSA-N 0.000 description 1
- 229960002049 etravirine Drugs 0.000 description 1
- PYGWGZALEOIKDF-UHFFFAOYSA-N etravirine Chemical compound CC1=CC(C#N)=CC(C)=C1OC1=NC(NC=2C=CC(=CC=2)C#N)=NC(N)=C1Br PYGWGZALEOIKDF-UHFFFAOYSA-N 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 229960002428 fentanyl Drugs 0.000 description 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 238000012632 fluorescent imaging Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
- 229960002870 gabapentin Drugs 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 208000005017 glioblastoma Diseases 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 238000004896 high resolution mass spectrometry Methods 0.000 description 1
- 239000004030 hiv protease inhibitor Substances 0.000 description 1
- 150000004050 homopiperazines Chemical class 0.000 description 1
- 102000053523 human CXCR4 Human genes 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- SXWRTZOXMUOJER-UHFFFAOYSA-N hydron;piperidin-4-one;chloride;hydrate Chemical compound O.Cl.O=C1CCNCC1 SXWRTZOXMUOJER-UHFFFAOYSA-N 0.000 description 1
- GRRNUXAQVGOGFE-NZSRVPFOSA-N hygromycin B Chemical compound O[C@@H]1[C@@H](NC)C[C@@H](N)[C@H](O)[C@H]1O[C@H]1[C@H]2O[C@@]3([C@@H]([C@@H](O)[C@@H](O)[C@@H](C(N)CO)O3)O)O[C@H]2[C@@H](O)[C@@H](CO)O1 GRRNUXAQVGOGFE-NZSRVPFOSA-N 0.000 description 1
- 229940097277 hygromycin b Drugs 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- CBVCZFGXHXORBI-PXQQMZJSSA-N indinavir Chemical compound C([C@H](N(CC1)C[C@@H](O)C[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H]2C3=CC=CC=C3C[C@H]2O)C(=O)NC(C)(C)C)N1CC1=CC=CN=C1 CBVCZFGXHXORBI-PXQQMZJSSA-N 0.000 description 1
- 229960001936 indinavir Drugs 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229940124524 integrase inhibitor Drugs 0.000 description 1
- 239000002850 integrase inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- SYJRVVFAAIUVDH-UHFFFAOYSA-N ipa isopropanol Chemical compound CC(C)O.CC(C)O SYJRVVFAAIUVDH-UHFFFAOYSA-N 0.000 description 1
- SRJOCJYGOFTFLH-UHFFFAOYSA-N isonipecotic acid Chemical compound OC(=O)C1CCNCC1 SRJOCJYGOFTFLH-UHFFFAOYSA-N 0.000 description 1
- JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
- 230000000155 isotopic effect Effects 0.000 description 1
- 125000000468 ketone group Chemical group 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 229960001627 lamivudine Drugs 0.000 description 1
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 229960004393 lidocaine hydrochloride Drugs 0.000 description 1
- YECIFGHRMFEPJK-UHFFFAOYSA-N lidocaine hydrochloride monohydrate Chemical compound O.[Cl-].CC[NH+](CC)CC(=O)NC1=C(C)C=CC=C1C YECIFGHRMFEPJK-UHFFFAOYSA-N 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 231100000516 lung damage Toxicity 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical class [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 235000012254 magnesium hydroxide Nutrition 0.000 description 1
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- QUXHCILOWRXCEO-UHFFFAOYSA-M magnesium;butane;chloride Chemical compound [Mg+2].[Cl-].CCC[CH2-] QUXHCILOWRXCEO-UHFFFAOYSA-M 0.000 description 1
- FRIJBUGBVQZNTB-UHFFFAOYSA-M magnesium;ethane;bromide Chemical compound [Mg+2].[Br-].[CH2-]C FRIJBUGBVQZNTB-UHFFFAOYSA-M 0.000 description 1
- YCCXQARVHOPWFJ-UHFFFAOYSA-M magnesium;ethane;chloride Chemical compound [Mg+2].[Cl-].[CH2-]C YCCXQARVHOPWFJ-UHFFFAOYSA-M 0.000 description 1
- SCEZYJKGDJPHQO-UHFFFAOYSA-M magnesium;methanidylbenzene;chloride Chemical compound [Mg+2].[Cl-].[CH2-]C1=CC=CC=C1 SCEZYJKGDJPHQO-UHFFFAOYSA-M 0.000 description 1
- UGVPKMAWLOMPRS-UHFFFAOYSA-M magnesium;propane;bromide Chemical compound [Mg+2].[Br-].CC[CH2-] UGVPKMAWLOMPRS-UHFFFAOYSA-M 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- BCVXHSPFUWZLGQ-UHFFFAOYSA-N mecn acetonitrile Chemical compound CC#N.CC#N BCVXHSPFUWZLGQ-UHFFFAOYSA-N 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- COTNUBDHGSIOTA-UHFFFAOYSA-N meoh methanol Chemical compound OC.OC COTNUBDHGSIOTA-UHFFFAOYSA-N 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- JASKBSUZIBFMPW-UHFFFAOYSA-N methyl 6-(1,4-diazepan-1-yl)pyridine-2-carboxylate Chemical compound COC(=O)C1=CC=CC(N2CCNCCC2)=N1 JASKBSUZIBFMPW-UHFFFAOYSA-N 0.000 description 1
- OTJGCKKQJUFVGV-UHFFFAOYSA-N methyl 6-(4-piperidin-4-yl-1,4-diazepan-1-yl)pyridine-2-carboxylate Chemical compound COC(=O)C1=CC=CC(N2CCN(CCC2)C2CCNCC2)=N1 OTJGCKKQJUFVGV-UHFFFAOYSA-N 0.000 description 1
- CJMAUXDKCLIJFT-UHFFFAOYSA-N methyl 6-[4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxylate Chemical compound COC(=O)C1=CC=CC(N2CCN(CCC2)C2CCN(CC=3C(=CC=CC=3)Cl)CC2)=N1 CJMAUXDKCLIJFT-UHFFFAOYSA-N 0.000 description 1
- 210000004088 microvessel Anatomy 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 125000004572 morpholin-3-yl group Chemical group N1C(COCC1)* 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229940074923 mozobil Drugs 0.000 description 1
- RRYVRUZDTCJIJR-UHFFFAOYSA-N n'-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound CC=1N=C(C=2N=C(NCCN)C=CC=2)NC=1C1CC1 RRYVRUZDTCJIJR-UHFFFAOYSA-N 0.000 description 1
- JOFNXUOLGVIXLF-UHFFFAOYSA-N n'-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound NCCNC1=CC=CC(C=2NC(=CN=2)C2CC2)=N1 JOFNXUOLGVIXLF-UHFFFAOYSA-N 0.000 description 1
- UFOPFDNIVNTMRH-UHFFFAOYSA-N n'-[6-(5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound N1C(CC)=CN=C1C1=CC=CC(NCCN)=N1 UFOPFDNIVNTMRH-UHFFFAOYSA-N 0.000 description 1
- LKARGPWSRYJXLJ-UHFFFAOYSA-N n'-cyclopentyl-n-[2-[[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethyl]propane-1,3-diamine Chemical compound C1CCCC1NCCCNCCNC(N=1)=CC=CC=1C(N1)=NC=C1C1CC1 LKARGPWSRYJXLJ-UHFFFAOYSA-N 0.000 description 1
- YLPKHKJNLBTGLW-UHFFFAOYSA-N n-(1-cyclopentylazepan-4-yl)-n'-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound CC=1N=C(C=2N=C(NCCNC3CCN(CCC3)C3CCCC3)C=CC=2)NC=1C1CC1 YLPKHKJNLBTGLW-UHFFFAOYSA-N 0.000 description 1
- YTKWDIXTCGVDOH-UHFFFAOYSA-N n-(1-cyclopentylpiperidin-3-yl)-n'-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound CC=1N=C(C=2N=C(NCCNC3CN(CCC3)C3CCCC3)C=CC=2)NC=1C1CC1 YTKWDIXTCGVDOH-UHFFFAOYSA-N 0.000 description 1
- WYQJOJZWSQJMHX-UHFFFAOYSA-N n-(1-cyclopentylpiperidin-3-yl)-n'-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound C1CCN(C2CCCC2)CC1NCCNC(N=1)=CC=CC=1C(N1)=NC=C1C1CC1 WYQJOJZWSQJMHX-UHFFFAOYSA-N 0.000 description 1
- NMXDLCVHFIKFKF-UHFFFAOYSA-N n-(1-cyclopentylpiperidin-4-yl)-n'-[6-(4-cyclopropyl-5-methyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound CC=1N=C(C=2N=C(NCCNC3CCN(CC3)C3CCCC3)C=CC=2)NC=1C1CC1 NMXDLCVHFIKFKF-UHFFFAOYSA-N 0.000 description 1
- HNRSQSOWPUPJQM-UHFFFAOYSA-N n-(1-cyclopentylpyrrolidin-3-yl)-n'-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound C1CN(C2CCCC2)CC1NCCNC(N=1)=CC=CC=1C(N1)=NC=C1C1CC1 HNRSQSOWPUPJQM-UHFFFAOYSA-N 0.000 description 1
- JROKBBVMJQNVNA-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-(1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCNCCC2)=NC=1C(=O)NCC1CC1 JROKBBVMJQNVNA-UHFFFAOYSA-N 0.000 description 1
- MZLXCEUTGHHJNX-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-(1-cyclopropylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C=1C=CC(N2CCN(CCC2)C2CCN(CC2)C2CC2)=NC=1C(=O)NCC1CC1 MZLXCEUTGHHJNX-UHFFFAOYSA-N 0.000 description 1
- FINMDSFGSIJYLU-UHFFFAOYSA-N n-(cyclopropylmethyl)-6-[4-(1-propylpiperidin-4-yl)-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound C1CN(CCC)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 FINMDSFGSIJYLU-UHFFFAOYSA-N 0.000 description 1
- KHJCULIGROZNMN-BPGUCPLFSA-N n-(cyclopropylmethyl)-6-[4-[(3r)-3-hydroxy-1-propan-2-ylpiperidin-4-yl]-1,4-diazepan-1-yl]pyridine-2-carboxamide Chemical compound O[C@@H]1CN(C(C)C)CCC1N1CCN(C=2N=C(C=CC=2)C(=O)NCC2CC2)CCC1 KHJCULIGROZNMN-BPGUCPLFSA-N 0.000 description 1
- IKRAUQDWOONKKD-UHFFFAOYSA-N n-[(1-cyclopentylpyrrolidin-3-yl)methyl]-n'-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound C1CN(C2CCCC2)CC1CNCCNC(N=1)=CC=CC=1C(N1)=NC=C1C1CC1 IKRAUQDWOONKKD-UHFFFAOYSA-N 0.000 description 1
- MOYYNISXFAVSEC-MRXNPFEDSA-N n-[1-[(2r)-butan-2-yl]piperidin-4-yl]-n'-[6-(5-ethyl-1h-imidazol-2-yl)pyridin-2-yl]ethane-1,2-diamine Chemical compound C1CN([C@H](C)CC)CCC1NCCNC1=CC=CC(C=2NC=C(CC)N=2)=N1 MOYYNISXFAVSEC-MRXNPFEDSA-N 0.000 description 1
- LBWFXVZLPYTWQI-IPOVEDGCSA-N n-[2-(diethylamino)ethyl]-5-[(z)-(5-fluoro-2-oxo-1h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C LBWFXVZLPYTWQI-IPOVEDGCSA-N 0.000 description 1
- YXLXRPJPXYARDX-UHFFFAOYSA-N n-butyl-6-(1,4-diazepan-1-yl)pyridine-2-carboxamide Chemical compound CCCCNC(=O)C1=CC=CC(N2CCNCCC2)=N1 YXLXRPJPXYARDX-UHFFFAOYSA-N 0.000 description 1
- NNKPHNTWNILINE-UHFFFAOYSA-N n-cyclopropyl-3-fluoro-4-methyl-5-[3-[[1-[2-[2-(methylamino)ethoxy]phenyl]cyclopropyl]amino]-2-oxopyrazin-1-yl]benzamide Chemical compound CNCCOC1=CC=CC=C1C1(NC=2C(N(C=3C(=C(F)C=C(C=3)C(=O)NC3CC3)C)C=CN=2)=O)CC1 NNKPHNTWNILINE-UHFFFAOYSA-N 0.000 description 1
- WOOWBQQQJXZGIE-UHFFFAOYSA-N n-ethyl-n-propan-2-ylpropan-2-amine Chemical compound CCN(C(C)C)C(C)C.CCN(C(C)C)C(C)C WOOWBQQQJXZGIE-UHFFFAOYSA-N 0.000 description 1
- MSOTVSWEABQIBJ-DOTOQJQBSA-N n-pyridin-4-yl-6-[(3r)-3-[[(3s)-pyrrolidin-3-yl]methylamino]pyrrolidin-1-yl]pyridine-2-carboxamide Chemical compound C=1C=CC(N2C[C@@H](CC2)NC[C@@H]2CNCC2)=NC=1C(=O)NC1=CC=NC=C1 MSOTVSWEABQIBJ-DOTOQJQBSA-N 0.000 description 1
- YZMHQCWXYHARLS-UHFFFAOYSA-N naphthalene-1,2-disulfonic acid Chemical compound C1=CC=CC2=C(S(O)(=O)=O)C(S(=O)(=O)O)=CC=C21 YZMHQCWXYHARLS-UHFFFAOYSA-N 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 229960000884 nelfinavir Drugs 0.000 description 1
- QAGYKUNXZHXKMR-HKWSIXNMSA-N nelfinavir Chemical compound CC1=C(O)C=CC=C1C(=O)N[C@H]([C@H](O)CN1[C@@H](C[C@@H]2CCCC[C@@H]2C1)C(=O)NC(C)(C)C)CSC1=CC=CC=C1 QAGYKUNXZHXKMR-HKWSIXNMSA-N 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 231100000189 neurotoxic Toxicity 0.000 description 1
- 230000002887 neurotoxic effect Effects 0.000 description 1
- 229960000689 nevirapine Drugs 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- VWBWQOUWDOULQN-UHFFFAOYSA-N nmp n-methylpyrrolidone Chemical compound CN1CCCC1=O.CN1CCCC1=O VWBWQOUWDOULQN-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- FIYYMXYOBLWYQO-UHFFFAOYSA-N ortho-iodylbenzoic acid Chemical compound OC(=O)C1=CC=CC=C1I(=O)=O FIYYMXYOBLWYQO-UHFFFAOYSA-N 0.000 description 1
- AHVQYHFYQWKUKB-UHFFFAOYSA-N oxan-4-amine Chemical compound NC1CCOCC1 AHVQYHFYQWKUKB-UHFFFAOYSA-N 0.000 description 1
- IPBPLHNLRKRLPJ-UHFFFAOYSA-N oxan-4-ylmethanamine Chemical compound NCC1CCOCC1 IPBPLHNLRKRLPJ-UHFFFAOYSA-N 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 208000005877 painful neuropathy Diseases 0.000 description 1
- NXJCBFBQEVOTOW-UHFFFAOYSA-L palladium(2+);dihydroxide Chemical compound O[Pd]O NXJCBFBQEVOTOW-UHFFFAOYSA-L 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- ICMWSAALRSINTC-UHFFFAOYSA-N penta-1,4-dien-3-ol Chemical compound C=CC(O)C=C ICMWSAALRSINTC-UHFFFAOYSA-N 0.000 description 1
- 210000004976 peripheral blood cell Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
- 244000087877 pink gum Species 0.000 description 1
- 235000002651 pink gum Nutrition 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 description 1
- 229920001983 poloxamer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- LZMJNVRJMFMYQS-UHFFFAOYSA-N poseltinib Chemical compound C1CN(C)CCN1C(C=C1)=CC=C1NC1=NC(OC=2C=C(NC(=O)C=C)C=CC=2)=C(OC=C2)C2=N1 LZMJNVRJMFMYQS-UHFFFAOYSA-N 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 229960001233 pregabalin Drugs 0.000 description 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000002248 primary sensory neuron Anatomy 0.000 description 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
- 229960003081 probenecid Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- HDOUGSFASVGDCS-UHFFFAOYSA-N pyridin-3-ylmethanamine Chemical compound NCC1=CC=CN=C1 HDOUGSFASVGDCS-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- CZFFBEXEKNGXKS-UHFFFAOYSA-N raltegravir Chemical compound O1C(C)=NN=C1C(=O)NC(C)(C)C1=NC(C(=O)NCC=2C=CC(F)=CC=2)=C(O)C(=O)N1C CZFFBEXEKNGXKS-UHFFFAOYSA-N 0.000 description 1
- 229960004742 raltegravir Drugs 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000004258 retinal degeneration Effects 0.000 description 1
- 229960000311 ritonavir Drugs 0.000 description 1
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 description 1
- 229960001852 saquinavir Drugs 0.000 description 1
- QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 229960001203 stavudine Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000013337 sub-cultivation Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 229940034785 sutent Drugs 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229960004556 tenofovir Drugs 0.000 description 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
- WDPWEXWMQDRXAL-UHFFFAOYSA-N tert-butyl 1,4-diazepane-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCNCC1 WDPWEXWMQDRXAL-UHFFFAOYSA-N 0.000 description 1
- HQMYWQCBINPHBB-UHFFFAOYSA-N tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate Chemical compound CC1CC(=O)CCN1C(=O)OC(C)(C)C HQMYWQCBINPHBB-UHFFFAOYSA-N 0.000 description 1
- CXBFRHLOLQIMFZ-UHFFFAOYSA-N tert-butyl 3-[2-[[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethylamino]piperidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC1NCCNC1=CC=CC(C=2NC(=CN=2)C2CC2)=N1 CXBFRHLOLQIMFZ-UHFFFAOYSA-N 0.000 description 1
- VHWORPGEIIJRNS-UHFFFAOYSA-N tert-butyl 3-[2-[[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethylcarbamoyl]pyrrolidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCC1C(=O)NCCNC1=CC=CC(C=2NC(=CN=2)C2CC2)=N1 VHWORPGEIIJRNS-UHFFFAOYSA-N 0.000 description 1
- UHYIHTLESJOREG-UHFFFAOYSA-N tert-butyl 3-[[6-(pyridin-4-ylcarbamoyl)pyridin-2-yl]amino]piperidine-1-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC1NC1=CC=CC(C(=O)NC=2C=CN=CC=2)=N1 UHYIHTLESJOREG-UHFFFAOYSA-N 0.000 description 1
- RIFXIGDBUBXKEI-UHFFFAOYSA-N tert-butyl 3-oxopiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC(=O)C1 RIFXIGDBUBXKEI-UHFFFAOYSA-N 0.000 description 1
- YCNIQRQNWZKNSM-UHFFFAOYSA-N tert-butyl 4-[1-[(2-chlorophenyl)methyl]piperidin-4-yl]-1,4-diazepane-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCCN1C1CCN(CC=2C(=CC=CC=2)Cl)CC1 YCNIQRQNWZKNSM-UHFFFAOYSA-N 0.000 description 1
- QOIVMGDVLOEJFD-LJQANCHMSA-N tert-butyl 4-[[(3r)-1-[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]pyrrolidin-3-yl]carbamoyl]piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1C(=O)N[C@H]1CN(C=2N=C(C=CC=2)C=2NC(=CN=2)C2CC2)CC1 QOIVMGDVLOEJFD-LJQANCHMSA-N 0.000 description 1
- JYUQEWCJWDGCRX-UHFFFAOYSA-N tert-butyl 4-formylpiperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(C=O)CC1 JYUQEWCJWDGCRX-UHFFFAOYSA-N 0.000 description 1
- MMPWHAJQEZIIEH-UHFFFAOYSA-N tert-butyl 7-oxa-4-azabicyclo[4.1.0]heptane-4-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCC2OC21 MMPWHAJQEZIIEH-UHFFFAOYSA-N 0.000 description 1
- DQQJBEAXSOOCPG-SSDOTTSWSA-N tert-butyl n-[(3r)-pyrrolidin-3-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H]1CCNC1 DQQJBEAXSOOCPG-SSDOTTSWSA-N 0.000 description 1
- OBZVKWBAUYBBIT-UHFFFAOYSA-N tert-butyl n-[3-[2-[[6-(5-cyclopropyl-1h-imidazol-2-yl)pyridin-2-yl]amino]ethylamino]-3-oxopropyl]carbamate Chemical compound CC(C)(C)OC(=O)NCCC(=O)NCCNC1=CC=CC(C=2NC(=CN=2)C2CC2)=N1 OBZVKWBAUYBBIT-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- MHNHYTDAOYJUEZ-UHFFFAOYSA-N triphenylphosphane Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 MHNHYTDAOYJUEZ-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 239000002525 vasculotropin inhibitor Substances 0.000 description 1
- 230000007501 viral attachment Effects 0.000 description 1
- 238000010451 viral insertion Methods 0.000 description 1
- 230000017613 viral reproduction Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229950000339 xinafoate Drugs 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
- 229960002555 zidovudine Drugs 0.000 description 1
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Definitions
- This invention relates to compounds that are CXCR4 antagonists, to compositions containing them, to processes for their preparation, and to their use in medicine, in particular for the treatment of conditions which respond to antagonism of the CXCR4 receptor, such as cancer (including cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma), cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, brain inflammation, diabetic retinopathy, age related macular degeneration, and retinal neo-vascularisation and to methods of preventing, treating or ameliorating these conditions.
- cancer including cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma
- cancer metastasis HIV/AIDS
- neuropathy HIV related neuropathy
- brain inflammation diabetic retinopathy
- This invention further relates to the use of compounds which are CXCR4 antagonists for use in stem cell apheresis procedures including, for example, promoting release and mobilisation of stem cells, including haematopoietic and non-haematopoietic stem cells and progenitor stem cells, prior to harvesting.
- CXCR4 is a G-protein coupled receptor whose natural endogenous ligand is the cytokine SDF-1 (stromal derived factor-1) or CXCL12. CXCR4 was first discovered as a co-receptor, with CD4, for the entry of T-cell line-tropic (X4) HIV-1 into T-cells. CXCR4 manipulation (in combination with granulocyte colony stimulating factor (G-CSF)) has proven to improve the outcome of haematopoietic (Broxmeyer et al., 2005) and endothelial progenitor cell (Pitchford et al., 2009) stem cell mobilization.
- G-CSF granulocyte colony stimulating factor
- the CXCR4-SDF-1 interaction is also a master regulator of cancer stem cell trafficking in the human body (Croker and Allan, 2008) and plays a key role in the progression and metastasis of various types of cancer cells in organs that highly express SDF-1 (Zlotnik, 2008).
- small molecule antagonists of the CXCR4 receptor are promising as future therapeutics for stem cell transplantation and for the treatment of diseases such as diabetic retinopathy, cancer, HIV and AIDS.
- FIG. 1 shows the effect of Example 30 in the attachment of CXCR4-tropic HIV-1 assay.
- FIG. 2 shows the effect of Example 30 in the HIV-1 antiviral assay.
- FIG. 3 shows a significant increase in circulating white blood cells (WBC) 1 hour after treatment with Example 30 when compared to mice in the vehicle control group.
- WBC white blood cells
- FIG. 4 shows the evaluation of hematopoietic progenitors following treatment with Example 30 and/or G-CSF.
- FIG. 4 shows a significant increase in multipotential mixed hematopoietic progenitors (CFU-GEMM/ml) one hour after treatment with Example 30 in combination with G-CSF when compared to G-CSF treatment alone.
- Haematopoietic stem cells or HSCs are widely used in the treatment of cancers of the haematopoietic system e.g. multiple myeloma and non-Hodgkin's lymphoma. Mobilisation and harvesting of HSCs allows the use of cytotoxic drugs to kill the tumour cells within the bone marrow. Subsequently the haematopoietic system can be re-introduced using the previously harvested stem cells.
- stem cells and progenitor cells are attracted to, and retained in, the bone marrow by the action of locally generated SDF-1 on CXCR4 expressed by such cells (see e.g. Lapidot et al., 2005).
- the stem cells used in transplantation can be mobilised from donors (allogeneic transplantation) or patients (autologous transplantation) after 4 or 5 days treatment with G-CSF.
- G-CSF is used in approximately 70 percent of the haematopoietic stem cell transplantations (the rest being bone marrow and umbilical cord transplants, Copelan, 2006) and acts by reducing the expression of CXCR4 in stem cells and reducing marrow SDF-1 levels (Levesque et al., 2003).
- CCR5 and HIV There is a known relationship between CCR5 and HIV (Alkhatib et al., 1996).
- the CXCR4 and CCR5 receptors act as entry cofactors for HIV infection.
- binding of the HIV gp120 protein to CD4 on the surface of CD4+ lymphocytes or macrophages exposes a domain in the gp120 protein which then also binds to the CCR5 or CXCR4 receptor, prior to viral insertion into the plasma membrane.
- CXCR4 antagonists have been shown to reduce the infectivity of X4 strains of the virus (Fransen et al., 2008), thus suggesting that the use of CXR4 antagonists would be effective treatments of HIV infection, especially in combination with CCR5 antagonists such as Maraviroc.
- the X4 strain of HIV is the most pathogenic, and these strains tend to predominate in the later stages of infection when neuropathic pain becomes an increasing problem for patients. Painful peripheral neuropathy affects approximately 50% of HIV patients.
- the HIV gp120 protein binds to CXCR4 and/or CCR5 which are expressed on neuronal and glial cells (Pardo et al, 2001; Oh et al., 2001), causing peripheral axonal damage (Melli et al, 2006) and initiating a cytokine-driven neurotoxic cascade involving glia and immune cells (Herzberg and Sagen, 2001; Milligan et al, 2000, 2001).
- the highly active anti-retroviral therapy can also cause painful neuropathy (Dalakas et al, 2001), but this is predicted to become less common as improved therapies are used.
- CXCR4 antagonists show both anti-viral, cognition enhancing and neuropathic pain relieving properties, and could be administered with other anti-(retro)viral therapies as well as analgesics such as amitryptiline, duloxetine and opiates.
- CXCR4 receptor Since the penetration of the blood brain barrier by leukocytes and monocytes is also influenced by the CXCR4 receptor, forms of brain inflammation and neurodegeneration (Bachis et al., J. Neuroscience, 2006, 26, 6771) whether virally induced or not, we expect to be amenable to therapy by CXCR4 antagonists (Kohler et al., 2008; McAndless et al., 2008). Similarly the expression of CXCR4 on primary sensory neurons suggests that antagonists of this receptor could act as analgesics in the control of pain (Oh et al., J Neurosci. 2001 21, 5027-35). In addition the potent chemotactic action of SDF-1 on inflammatory cells (Gouwy et al., Eur J Immunol. 2011 41, 963-73), suggests that CXCR4 antagonists could serve as anti-inflammatory therapeutics.
- Retinal neo-vascularisation is a major cause of blindness in patients with diabetes and age related macular degeneration.
- the SDF-1/CXCR4 axis is strongly implicated in ocular neo-vascularisation and has been suggested as a target for treating diabetic retinopathy.
- Blockade of the CXCR4 receptor prevents the recruitment of endothelial progenitor cells, essential for the formation of the new microvessels which are part of the pathology of diabetic retinopathy (Lima e Silva et al., 2009).
- CXCR4 antagonists we expect the effects of CXCR4 antagonists to be additive with those of VEGF antibodies such as avastin.
- topical or intravitreal administration of CXCR4 antagonist to be an effective treatment of retinal degeneration with diabetes and ageing.
- CXCR4 Several types of cancers (including non-small cell lung, breast and neuroblastoma) express CXCR4, and SDF-1 is highly expressed in internal organs that represent the primary metastatic destinations of the corresponding cancer cells (for review see Ben Baruch, 2008). CXCR4 and SDF-1 are also implicated in the maintenance of cancer stem cells (Wang et al., 2006; Croker and Allan, 2008) and in the recurrence of tumours after radiation therapy. The role of the SDF-1/CXCR4 axis in cancer and cancer stem cells metastasis is discussed in Gelmini S et al., 2008.
- Blockade of CXCR4 prevented both the vasculogenesis and recurrence of glioblastoma multiforme tumours (Kioi et al., 2010), after radiation treatment.
- This ability to inhibit tumour derived vasculogenesis leads us to expect that CXCR4 antagonists will be effective when dosed with other anti-angiogenic agents including those that inhibit VEGF (e.g.
- VEGF and PDGFreceptors such as cediranib, sunitinib, sorafenib, pazopanib, tivozanib vatalanib, vandertanib, brivanib, dovitinib, motesanib, telatinib and axitinib (Bhargava and Robinson Curr Oncol Rep (2011) 13:103-111).
- CXCR4 antagonists include those which inhibit EGF, angiopioetins, MMP-9, TNF, bFGF, CXCL8, HGF and TF (Nozawa et al., Proc Natl Acad Sci USA. 103, 12493-12498, 2006; Murdoch et al., Nature Reviews Cancer 8, 618631 2008). Therefore we expect CXCR4 antagonists to be useful in the prevention of metastasis, and in anti-angiogenic treatment, as well as in cancer stem cell protection and maintenance, and in the sensitization of tumours to radiotherapy.
- This invention makes available a class of compounds which are antagonists of the CXCR4 receptor, and their use in indications which respond to the antagonism of the CXCR4 receptor such as those mentioned above.
- R 1 is selected from hydrogen, C 1-4 -alkyl, cyano, —COR 5 , —CONR 3 R 4 and heteroaryl, wherein
- Y is selected from radicals of formulae (H), (J), (K), (L) and (M) any of which is optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl, a divalent C 1-4 -alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, C 1-4 -alkoxy, fluoro-C 1-4 -alkyl, a divalent fluoro-C 1-4 -alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine and fluoro-C 1-4 -alkoxy, wherein the bond marked * is attached to X and the bond marked ** is attached to R 2 :
- R 20 is hydrogen, or C 1-4 -alkyl
- R 2 is selected from radicals of formulae (N)-(S) inclusive, any of which is optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl, C 1-4 -alkoxy, fluoro-C 1-4 -alkyl and fluoro-C 1-4 -alkoxy, wherein the bond marked * is attached to Y:
- R 3 is selected from hydrogen, C 1-6 -alkyl, C 3-5 cycloalkyl, C 3-5 -cycloalkyl-C 1-4 -alkyl, heterocyclyl, heterocyclyl-C 1-4 heteroaryl, C 6-10 -alkyl, C 6-10 -aryl, aryl-C 1-4 -alkyl and heteroaryl-C 1-4 -alkyl, wherein
- Compounds of formula (I) above may be prepared in the form of salts, especially pharmaceutically acceptable salts, N-oxides, hydrates, solvates and polymorphic forms thereof.
- the compounds of the invention are antagonists of the CXCR4 receptor. Therefore, in another broad aspect the invention provides the use of a compound of the invention in the treatment of, or in the preparation of a composition for treatment of, diseases or conditions responsive to the reduction of CXCR4 mediated activity.
- diseases or conditions which are responsive to the reduction of CXCR4 mediated activity include cancer including cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma, cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, pain, inflammation, brain inflammation, neurodegeration, cognative degeneration, diabetic retinopathy, age related macular degeneration, retinal neo-vascularisation, and viral infections.
- the compounds with which the invention is concerned may be used for the reduction of CXCR4 mediated activity, ex vivo or in vivo.
- the compounds of the invention may be used in the preparation of a composition for the treatment of cancer including cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma, cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, pain, inflammation, brain inflammation, neurodegeration, cognative degeneration, diabetic retinopathy, age related macular degeneration, retinal neo-vascularisation, and viral infections.
- cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma, cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, pain, inflammation, brain inflammation, neurodegeration, cognative degeneration, diabetic retinopathy, age related macular degeneration, retinal neo-vascularisation, and viral infections.
- the invention provides a method for the treatment of the foregoing disease types, which comprises administering to a subject suffering such disease an effective amount of a compound of the invention.
- the compounds of the invention may be used for stem cell apheresis including haematopoietic stem cell mobilisation and non-haematopoietic stem and progenitor cell mobilization.
- Apheresis in its broadest meaning is a procedure in which blood is drawn and separated into its components, for example by dialysis; some components are retained and the rest are used for further medical procedures such as being returned to the donor or another subject by transfusion.
- apheresis may be applied, for example, to harvest stem cells from plasma for subsequent use in stem cell transplantation.
- a further example of a therapeutic application of stem cell apheresis is in reducing leukopenia which would otherwise be a consequence of chemotherapy or radiotherapy. Stem cells are damaged during chemo- or radiotherapy, and stem cell apheresis may be used to harvest stem cells from the body prior to such treatment, and then returned undamaged to the body once the radio- or chemotherapy is finished.
- the apheresis procedure may be implemented prior to treatment of a subject by chemotherapy or radiotherapy, in order to reduce chemotherapy- or radiotherapy-induced leukopenia.
- the compounds of the invention may be administered as an adjunct to chemotherapy or radiotherapy to sensitize tumours to such chemotherapy or radiotherapy.
- the compounds of the invention may be used for inhibition of neo-vascularisation, angiogenesis, or vasculogenesis.
- composition comprising a compound of the invention together with one or more pharmaceutically acceptable carriers and/or excipients.
- a pharmaceutical composition comprising a compound of the invention together with one or more anti-angiogenic agents.
- the anti-angiogenic agent is an inhibitor of the VEGF receptor.
- the anti-angiogenic agent is an inhibitor of the PDGF receptor.
- the anti-angiogenic agent is selected from cediranib, sunitinib, sorafenib, pazopanib, tivozanib vatalanib, vandertanib, brivanib, dovitinib, motesanib, telatinib and axitinib.
- the compounds of the invention may be administered in a variety of dosage forms. Thus, they can be administered orally, for example as tablets, capsules, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules.
- the compounds can be administered in a sublingual formulation, for example a buccal formulation.
- the compounds of the invention may also be administered parenterally, whether subcutaneously, intravenously, intramuscularly, intrasternally, transdermally, by inhalation, intranasally, or by infusion techniques.
- the compounds may also be administered as suppositories.
- the compounds of the invention are administered orally, or by inhalation, or intranasally, but preferably the compounds of the invention are administered orally and more preferably, the compounds of the invention are administered as a tablet or capsule.
- solid oral forms may contain, together with the active compound, diluents, e.g. lactose, dextrose, saccharose, cellulose, corn starch or potato starch; lubricants, e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents; e.g. starches, arabic gums, gelatin, methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disaggregating agents, e.g.
- diluents e.g. lactose, dextrose, saccharose, cellulose, corn starch or potato starch
- lubricants e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols
- binding agents e.g. starches, arabic gums, gelatin, methylcellulose, carboxymethylcellulose or polyvinyl pyrroli
- Such pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tableting, sugar coating, or film coating processes.
- Liquid dispersions for oral administration may be syrups, emulsions and suspensions.
- the syrups may contain as carriers, for example, saccharose or saccharose with glycerine and/or mannitol and/or sorbitol.
- Suspensions and emulsions may contain as carrier, for example a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or polyvinyl alcohol.
- the suspension or solutions for intramuscular injections may contain, together with the active compound, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and if desired, a suitable amount of lidocaine hydrochloride.
- the present invention further provides a pharmaceutical composition containing a compound of the invention or a pharmaceutically acceptable salt thereof, as defined above, and a pharmaceutically acceptable carrier in the form of a capsule or tablet.
- Solutions for injection or infusion may contain as carrier, for example, sterile water or preferably they may be in the form of sterile, aqueous, isotonic saline solutions.
- the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, rate of excretion, drug combination and the severity of the particular disease undergoing treatment. Optimum dose levels and frequency of dosing will be determined by clinical trial, as is required in the art. However, it is expected that a typical dose will be in the range from about 0.001 to 50 mg per kg of body weight.
- halogen denotes a fluoro, chloro, bromo or iodo substituent. In a presently preferred embodiment halogen is fluoro or chloro.
- C a-b ,-alkyl wherein a and b are integers denotes a straight or branched alkyl group having from a to b carbon atoms.
- C 1-4 -alkyl includes methyl, ethyl, n-propyl, isopropyl, n-butyl, iso-butyl, sec-butyl and tert-butyl and “C 1-6 -alkyl” includes the foregoing and straight- and branched-chain pentyl and hexyl.
- fluoro-C a-b ,-alkyl wherein a and b are integers denotes a straight or branched C a-b -alkyl group substituted by one or more fluorine atoms.
- fluoro-C 1-4 -alkyl includes fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl.
- C a-b -alkoxy wherein a and b are integers refers to a straight or branched C a-b -alkyl group which is attached to the remainder of the molecule through an oxygen atom.
- C 1-4 -alkoxy includes methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy.
- fluoro-C a-b -alkoxy wherein a and b are integers denotes a fluoro-C a-b -alkyl group which is attached to the remainder of the molecule through an oxygen atom.
- fluoro-C 1-4 -alkoxy groups include trifluoromethoxy and 2,2,2-trifluoroethoxy.
- C a-b ,-alkoxy-C c-d -alkyl wherein a, b, c and d are integers denotes a straight or branched alkoxy group having from a to b carbon atoms connected to a straight or branched alkyl group having from c to d carbon atoms.
- C 1-4 -alkoxy-C 1-4 -alkyl includes methoxymethyl, methoxyethyl, ethoxyethyl, iso-propoxyethyl, n-butoxyethyl and tert-butoxyethyl.
- C 1-2 -alkoxy-C 1-4 -alkyl includes methoxymethyl, methoxyethyl, and ethoxyethyl.
- fluoro-C a-b -alkoxy-C c-d -alkyl wherein a, b, c and d are integers denotes a C a-b -alkoxy-C c-d -alkyl group substituted by one or more fluorine atoms.
- fluoro-C 1-4 -alkoxy-C 1-4 -alkyl includes trifluoromethoxymethyl and trifluoromethoxyethyl.
- C a-b -cycloalkyl wherein a and b are integers denotes a saturated monocyclic hydrocarbon ring having from a to b carbon atoms.
- C 3-5 -cycloalkyl includes cyclopropyl, cyclobutyl and cyclopentyl.
- C 3-5 -cycloalkyl also includes a cyclopropyl, cyclobutyl or cyclopentyl ring system which is fused to a C 6-10 -aryl group such as phenyl.
- C a-b -cycloalkyl-C c-d -alkyl wherein a, b, c and d are integers denotes a saturated monocyclic hydrocarbon ring having from a to b carbon atoms connected to a straight or branched alkyl group having from c to d carbon atoms.
- C 3-5 -cycloalkyl-C 1-4 -alkyl includes cyclopropylmethyl and cyclobutylmethyl.
- heterocyclyl or “heterocyclic ring” denotes a saturated, monocyclic ring having from 4 to 7 ring atoms with at least one heteroatom such as O, N, or S, and the remaining ring atoms are carbon.
- heterocyclic rings include piperidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, azetidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, dioxanyl, piperazinyl and homopiperazinyl.
- the sulfur atom may be in an oxidized form (i.e., S ⁇ O or O ⁇ S ⁇ O).
- exemplary heterocyclic groups containing sulfur in oxidized form are 1,1-dioxido-thiomorpholinyl and 1,1-dioxido-isothiazolidinyl.
- heterocyclyl or “heterocyclic ring” also includes a ring system in which the “heterocyclyl” or “heterocyclic ring” is fused to a C 6-10 -aryl ring system, such as phenyl.
- heterocyclyl-C ab -alkyl wherein a and b are integers denotes a heterocyclic ring as defined above that is directly attached to a straight or branched C a-b -alkyl group via a carbon or nitrogen atom of said ring.
- heterocyclyl-C 1-4 -alkyl groups include piperidin-1-ylmethyl, piperidin-4-ylmethyl and morpholin-4-ylmethyl.
- heteroaryl denotes a monocyclic or fused bicyclic heteroaromatic ring system comprising 5 to 10 ring atoms in which one or more of the ring atoms are other than carbon, such as nitrogen, sulphur or oxygen. Only one ring need to be aromatic and said heteroaryl moiety can be linked to the remainder of the molecule via a carbon or nitrogen atom in any ring.
- heteroaryl groups include furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, imidazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, quinazolinyl, indolyl, indolinyl, isoindolyl, isoindolinyl, pyrazolyl, pyridazinyl, pyrazinyl, quinolinyl, quinoxalinyl, oxadiazolyl, thiadiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 1,3-benzodioxolyl, 1,4-benzodioxinyl, benzothiazolyl, benzimidazolyl, azabenzimidazole, benzotriazolyl and chromanyl.
- C a-b -aryl wherein a and b are integers denotes a monocyclic or fused bicyclic hydrocarbon ring system comprising a to b ring atoms and wherein at least one ring is an aromatic ring.
- C 6-10 -aryl groups include phenyl, indenyl, 2,3-dihydroindenyl (indanyl), 1-naphthyl, 2-naphthyl or 1,2,3,4-tetrahydronaphthyl.
- C ab -aryl-C c-d -alkyl wherein a, b, c and d are integers refers to a C a-b -aryl group that is directly linked to a straight or branched C c-d -alkyl group.
- C 6-10 -aryl-C 1-4 -alkyrgroups include phenylmethyl (i.e., benzyl) and phenylethyl.
- heteroaryl-C a-b -alkyl wherein a and b are integers denotes a heteroaryl ring as defined above that is directly linked to a straight or branched Cab alkyl group via a carbon or nitrogen atom of said ring.
- heteroaryl-C 1-4 -alkyl groups include 2-(pyridin-2-yl)-ethyl and 1,2,4-oxadiazol-5-ylmethyl.
- Compounds of the invention may exist in one or more geometrical, optical, enantiomeric, diastereomeric and tautomeric forms, including but not limited to cis- and trans-forms, E- and Z-forms, R-, S- and I-forms, keto-, and enol-forms. Unless otherwise stated a reference to a particular compound includes all such isomeric forms, including racemic and other mixtures thereof. Where appropriate such isomers can be separated from their mixtures by the application or adaptation of known methods (e.g. chromatographic techniques and recrystallisation techniques). Where appropriate such isomers may be prepared by the application of adaptation of known methods (e.g. asymmetric synthesis).
- salt includes base addition, acid addition and ammonium salts.
- compounds of the invention which are acidic can form salts, including pharmaceutically acceptable salts, with bases such as alkali metal hydroxides, e.g. sodium and potassium hydroxides; alkaline earth metal hydroxides e.g. calcium, barium and magnesium hydroxides; with organic bases e.g. N-methyl-D-glucamine, choline tris(hydroxymethyl)amino-methane, L-arginine, L-lysine, N-ethyl piperidine, dibenzylamine and the like.
- bases such as alkali metal hydroxides, e.g. sodium and potassium hydroxides; alkaline earth metal hydroxides e.g. calcium, barium and magnesium hydroxides; with organic bases e.g. N-methyl-D-glucamine, choline tris(hydroxymethyl)amino-methane, L-arginine, L-lysine, N-ethyl piperidine,
- hydrohalic acids such as hydrochloric or hydrobromic acids, sulphuric acid, nitric acid or phosphoric acid and the like
- organic acids e.g. with acetic, trifluoroacetic, tartaric, succinic, fumaric, maleic, malic, salicylic, citric, methanesulphonic, p-toluenesulphonic, benzoic, benzenesulfonic, glutamic, lactic, and mandelic acids and the like.
- Those compounds (I) which have a basic nitrogen can also form quaternary ammonium salts with a pharmaceutically acceptable counter-ion such as chloride, bromide, acetate, formate, p-toluenesulfonate, succinate, hemi-succinate, naphthalene-bis sulfonate, methanesulfonate, trifluoroacetate, xinafoate, and the like.
- a pharmaceutically acceptable counter-ion such as chloride, bromide, acetate, formate, p-toluenesulfonate, succinate, hemi-succinate, naphthalene-bis sulfonate, methanesulfonate, trifluoroacetate, xinafoate, and the like.
- Some compounds of the invention having a nitrogen atom in an aromatic ring, may form N-oxides, and the invention includes compounds of the invention in their N-oxide form.
- the compounds of the invention in any compatible combination, and bearing in mind that the compounds preferably have a molecular weight of less than 600:
- R 1 is selected from hydrogen, C 1-4 -alky such as methyl, ethyl, n- or isopropyl, n-, sec- or tert-butyl, cyano, —CONR 3 , —CONR 3 R 4 and heteroaryl such as furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, imidazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, quinazolinyl, indolyl, indolinyl, isoindolyl, isoindolinyl, pyrazolyl, pyridazinyl, pyrazinyl, quinolinyl, quinoxalinyl, oxadiazolyl, thiadiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 1,3
- X is selected from radicals of formulae (A), (B), (C), (D), (E), or (F) inclusive, any of which being optionally substituted with one more substituents independently selected from halogen such as fluoro, chloro, bromo, cyano, nitro, C 1-4 -alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, C 1-4 -alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C 1-4 -alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, and fluoro-C 1-4 -alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy,
- Y is selected from radicals of formulae (H) such as piperazine and homopiperazine, (J) such as amino-piperidine and amino-homopiperidine, (K) such as amino-piperidine and amino-homopiperidine, (L) such as 1,2-diaminoethane and 1,3-diamino propane, and (M) such as oxy-piperidine, any of which is optionally substituted with one more substituents independently selected from, fluorine, hydroxyl, C 1-4 -alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl a divalent C 1-4 -alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, examples include —CH 2 —, —CH 2 CH 2 — and —CH 2 CH 2 CH 2 —, C 1-4 -alkoxy such as methoxy, ethoxy,
- R 2 is selected from radicals of formulae (N), (0), (P), (Q), (R), and (S) inclusive, any of which is optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, C 1-4 -alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C 1-4 -alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl and fluoro-C 1-4 -alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy,
- R 3 is selected from hydrogen, C 1-6 -alkyl such as methyl, ethyl, n- or isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, straight or branched pentyl and hexyl, C 3-5 -cycloalkyl such as cyclopropyl, cyclobutyl and cyclopentyl, C 3-5 -cycloalkyl-C 1-4 -alkyl such as cyclopropylmethyl and cyclobutylmethyl, heterocyclyl such as piperidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, azetidinyl, pyrrolidinyl, morpholinyl, imidazolidinyl, thiomorpholinyl, dioxanyl, piperazinyl, homopiperazinyl, 1-dioxide, C
- R 4 , R 5A and R 5B are each independently selected from hydrogen, C 1-4 -alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, and fluoro-C 1-4 -alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, or
- R 3 and R 4 together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring such as pyrrolidine, piperidine, homopiperidine, piperazine, homopiperazine and morpholine, or a heteroaryl ring such as pyrrole, imidazole, indole, isoindole, indazole, or purine, said ring being optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, fluoro-C 1-4 -alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, and C 1-4 -alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy,
- R 6 is selected from C 1-6 -alkyl such as methyl, ethyl, n- or iso-propyl, n-butyl, isobutyl, sec-butyl and tert-butyl, and straight or branched pentyl and hexyl, C 3-5 -cycloalkyl such as cyclopropyl, cyclobutyl and cyclopentyl, C 3-5 -cycloalkyl-C 1-4 -alkyl such as cyclopropylmethyl and cyclobutylmethyl, heterocyclyl such as piperidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, azetidinyl, pyrrolidinyl, morpholinyl, imidazolidinyl, thiomorpholinyl, dioxanyl, piperazinyl, homopiperazinyl 1,1-di
- R 8A , R 8B and R 9 are each independently selected from hydrogen, C 3-5 -cycloalkyl such as cyclopropyl or cyclobutyl or cyclopentyl, C 6-10 aryl-C 1-4 alkyl such as phenyl methyl (benzyl) and C 1-6 -alkyl such as methyl, ethyl, n- or iso-propyl, n-butyl, isobutyl, sec-butyl and t-butyl, and straight or branched pentyl and hexyl, wherein any alkyl residue is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C 1-4 -alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, or
- R 8A and R 8B together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring such as pyrrolidine, piperidine homopiperidine, piperazine, homopiperazine and morpholine, optionally substituted with one or more substituents independently selected from halogen such as fluoro or chloro, hydroxyl, C 1-4 -alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, fluoro-C 1-4 -alkyl and C 1-4 -alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy or the 4-7 membered saturated heterocyclic ring is optionally fused to a C 6-10 aryl or heteroaryl ring system, the 4-7 membered saturated heterocyclic ring or the
- R 10A and R 10B are each independently selected from hydrogen and C 1-6 -alkyl such as methyl, ethyl, n- or iso-propyl, n-butyl, isobutyl, sec-butyl and t-butyl, straight or branched pentyl and hexyl, wherein said C 1-6 -alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C 1-4 -alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, or
- R 10A and R 10B together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring ring such as pyrrolidine, piperidine homopiperidine, piperazine, homopiperazine and morpholine or a heteroaryl ring such as pyrrole, imidazole, indole, isoindole, indazole, and purine, optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, fluoro-C 1-4 -alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl and C 1-4 -alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-but
- R 1 is CONR 3 R 4 or heteroaryl such as benzoxazolyl, indolyl, azaindolyl, imidazolyl, benzimidazolyl, oxazolyl, oxadiazolyl or tetrazolyl, any of which may be optionally substituted with one or more substituents independently selected from, for example, halogen such as fluoro, chloro, cyano, C 1-6 -alkyl such as methyl, ethyl, propyl, iso-propyl, tert-butyl, n-butyl, C 3-5 -cycloalkyl such as cyclopropyl, cyclopentyl, C 1-4 -alkoxy such as methoxy, fluoro-C 1-6 -alkyl such as trifluoromethyl, fluoro-C 1-4 -alkoxy, and heteroaryl such as pyridyl.
- halogen such as fluoro, chlor
- R 1 is CONR 3 R 4 wherein R 4 is hydrogen or methyl and R 3 is selected from tetrahydropyranyl, isopropylmethyl, tetrahydropyranylmethyl, imidazolylethyl, methoxyethyl, N-methylimidazolylmethyl, tetrahydrofuranylmethyl, 1-fluoroethyl, oxazolylmethyl, pyridylmethyl, 2,2-difluoromethyl, tetrahydrofuranyl, methyl, ethyl, n- or iso-propyl, n-sec- or tert-butyl, cyclopropyl, hydroxyethyl, cyanoethyl, phenyl, pyridyl, chlorophenyl, methoxyphenyl, methylphenyl, hydroxyphenyl, thiazoloylmethyl, indolyl, methoxyprop
- X is a 2,6-pyridyl radical of formula (A).
- Y is a homopiperazinyl radical of formula (H) when n is 2, or a piperazine radical of formula (H) when n is 1, either of which being optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl such as methyl, a divalent C 1-4 -alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine such as —CH 2 CH 2 — or —CH 2 CH 2 CH 2 —, C 1-4 -alkoxy such as methoxy, fluoro-C 1-4 -alkyl such as di- and trifluoromethyl, or a divalent fluoro-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, and fluoro-C 1-4 -alkoxy such as mono-, di-, and tri-fluoromethoxy.
- Y is a homopiperazinyl radical of formula (H) when n is 2, or a piperazine radical of formula (H) when n is 1, either of which being optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl such as methyl, a divalent C 1-4 -alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine such as -ethylene- or -propylene-, C 1-4 -alkoxy such as methoxy, fluoro-C 1-4 -alkyl such as di- and trifluoromethyl, or a divalent fluoro-C 1-4 -alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, and fluoro-C 1-4 -alkoxy such as mono-, di-, and tri-fluoromethoxy, and R 2 is selected from a 4-piperidine radical
- Y is a piperazine radical of formula (H) wherein n is 1, optionally substituted as defined above, and R 2 is a 4-azepine radical of formula (N) wherein 0 is 2 and p is 2, said 4-azepine radical being optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C 1-4 -alkyl such as methyl, C 1-4 -alkoxy such as methoxy, fluoro-C 1-4 -alkyl such as trifluoromethyl, and fluoro-C 1-4 -alkoxy.
- R 3 is pyridyl optionally substituted with one or more substituents selected from halogen such as fluoro or chloro, C 1-4 -alkyl such as methyl or ethyl or isopropyl, C 1-4 -alkoxy such as methoxy, or fluoro-C 1-4 -alkyl.
- R 3 is 4-pyridyl optionally substituted with one or more methyl groups.
- the compounds of the invention are useful in the treatment of cancers.
- cancers include cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma.
- other drugs which may be used in combination with the compounds of the invention for the treatment of cancers, including for example cancers of the haematopoietic system, include agents that inhibit growth factors such as GCSF and VEGF (e.g. avastin and aflibercept).
- the compounds of the invention are also useful in the treatment of injuries including damage to the heart, liver, kidney, brain, and bone.
- examples of other drugs which may be used in combination with the compounds of the invention for the treatment of such injuries include agents that inhibit growth factors such as GCSF and VEGF.
- the compounds of the invention are useful in the treatment of viral infections, for example HIV/AIDS.
- examples of other drugs which may be used in combination with the compounds of the invention for the treatment of viral infections include, for example, CCR5 antagonists including maraviroc and SCH532702, and antiretrovirals including reverse transcriptase inhibitors (e.g. zidovudine, abacavir, didanosine, zalcitabine, stavudine, lamivudine, emtricitabine, tenofovir, adefovir, nevirapine efavirenz, etravirine, delavirdineetc), and HIV protease inhibitors (e.g.
- saquinavir ritonavir, indinavir, nelfinavir, amprenavir
- integrase inhibitors e.g. raltegravir
- antivirals such as acyclovir and plecoranil.
- the compounds of the invention are useful in the treatment of neuropathy.
- An example of neuropathy is HIV related peripheral neuropathy, which affects approximately 50% of HIV patients.
- examples of other drugs which may be used in combination with the compounds of the invention for the treatment of neuropathy, including HIV related peripheral neuropathy include opiates such as fentanyl, anti-epileptics such as gabapentin and pregabalin, and tricyclics such as amitryptiline.
- the compounds of the invention are useful in the treatment of retinal neo-vascularisation, which is a major cause of blindness in patients with diabetes and age related macular degeneration.
- examples of other drugs which may be used in combination with the compounds of the invention for the treatment of retinal neo-vascularisation include VEGF inhibitors such as avastin and lucentis.
- the compounds of the invention are useful in the treatment of several types of cancers, including non-small cell lung, breast and neuroblastoma.
- examples of other drugs which may be used in combination with the compounds of the invention for the treatment of cancer include other anti-cancer drugs including anti-angiogenic agents such as avastin and inhibitors of VEGF and PDGF receptors such as lucentis and sutent.
- the compounds of formula (I) above may be prepared by, or in analogy with, conventional methods.
- the preparation of intermediates and compounds according to the examples of the present invention may in particular be illuminated by, but not limited to, the following Schemes. Definitions of variables in the structures in the schemes herein are commensurate with those of the corresponding positions in the formulae delineated herein.
- R 1 , R 2 , R 3 , R 4 , X and Y are as defined in formula (I).
- Intermediate compounds of general formula (III) can be readily prepared for example by Suzuki reaction of a boronic acid R′B(OH) 2 with 2-chloro-6-iodopyridine, by condensation of an amine R 3 R 4 NH 2 with 6-chloropyridine-2-carboxylic acid or by condensation of an a-halo ketone with 6-chloropyridine-2-carboximidamide. All of these alternatives are exemplified in the experimental section below.
- R 1 , R 2 , R 3 , R 4 , X and Y are as defined in formula (I).
- the groups R 1 and R 2 in Schemes 1 and 2 can also be converted by standard synthetic methods into alternative groups R 1 and R 2 .
- the routes described in Schemes 1 and 2 refer to X being a 2,6-pyridyl radical of formula (A). Analogous methods can be used to prepare compounds of formula (I) where X is alternatively a radical of formulae (B)-(G) inclusive.
- reaction conditions for the individual reaction steps are known to a person skilled in the art. Particular reaction conditions for examples of the invention are also described in the experimental section.
- the necessary starting materials for preparing the compounds of formula (I) are either commercially available, or may be prepared by methods known in the art.
- a pharmaceutically acceptable acid addition salt may be obtained by dissolving the free base in a suitable organic solvent and treating the solution with an acid, in accordance with conventional procedures for preparing acid addition salts from base compounds. Examples of addition salt forming acids are mentioned above.
- the compounds of formula (I) may possess one or more chiral carbon atoms, and they may therefore be obtained in the form of optical isomers, e.g., as a pure enantiomer, or as a mixture of enantiomers (racemate) or as a mixture containing diastereomers.
- optical isomers e.g., as a pure enantiomer, or as a mixture of enantiomers (racemate) or as a mixture containing diastereomers.
- the separation of mixtures of optical isomers to obtain pure enantiomers is well known in the art and may, for example, be achieved by fractional crystallization of salts with optically active (chiral) acids or by chromatographic separation on chiral columns.
- the chemicals used in the synthetic routes delineated herein may include, for example, solvents, reagents, catalysts, and protecting group and deprotecting group reagents.
- protecting groups are t-butoxycarbonyl (Boc) and benzyl.
- the methods described above may also additionally include steps, either before or after the steps described specifically herein, to add or remove suitable protecting groups in order to ultimately allow synthesis of the compounds.
- various synthetic steps may be performed in an alternate sequence or order to give the desired compounds.
- Synthetic chemistry transformations and protecting group methodologies (protection and deprotection) useful in synthesizing applicable compounds are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations, VCH Publishers (1989); T. W.
- Flash chromatography was performed on either a CombiFlash Companion system equipped with RediSep or GraceResolv silica columns or a Flash Master Personal system equipped with Strata SI-1 silica gigatubes or in a glass column under gravity (ICN silica, 18-32 ⁇ m, 60 ⁇ ).
- Reverse Phase HPLC was performed on a Gilson system (Gilson 322 pump with Gilson 321 equilibration pump and Gilson 215 autosampler) equipped with Phenomenex Synergi Hydro RP 150 ⁇ 10 mm, ACE-SAQ, 100 ⁇ 21.20 mm or YMC ODS-A 100/150 ⁇ 20 mm columns.
- Reverse phase column chromatography was performed on a Gilson system (Gilson 321 pump and Gilson FC204 fraction collector) equipped with Merck LiChroprep® RP-18 (40-63 um) silica columns.
- Microwave irradiations were carried out using a Biotage or CEM microwave. Hydrogenations were performed using a Thales H-cube or H-cube midi.
- 1,4-Pentadien-3-ol 200 mg, 2.38 mmol
- IBX 999 mg, 3.57 mmol
- DCE 15 mL
- the reaction mixture was filtered, diluted with MeOH (10 mL) and 2-fluoro-1-fluoromethyl-ethylamine (226 mg, 2.38 mmol) was added.
- the reaction mixture was stirred at 70° C. for 3 h.
- Isocyanate resin was added and the reaction mixture stirred at room temperature for 6 h, filtered and concentrated in vacuo to give the crude title compound (160 mg, 38%) as an orange gum.
- 6-Chloropyridine-2-carboxylic acid (5.00 g, 31.7 mmol) was dissolved in DCM (150 mL) and oxalyl chloride (5.45 mL, 63.5 mmol) and DMF (1 mL) were added. The reaction mixture was stirred for 3 h, concentrated in vacuo and azeotroped with DCM. The residue was dissolved in THF (150 mL) and potassium tert-butoxide (3.39 mg, 47.6 mmol) was added. The reaction mixture was stirred for 18 h, quenched with water (250 mL) and extracted with DCM (3 ⁇ 150 mL).
- 6-Chloropyridine-2-carboxylic acid (5.00 g, 31.7 mmol) was dissolved in DCM (100 mL) and DMF (0.5 mL) and oxalyl chloride (6.54 mL, 76.2 mmol) were added dropwise. The reaction mixture was stirred for 2 h, concentrated in vacuo and azeotroped with DCM. The residue was dissolved in DCM (100 mL), DIPEA (22.6 mL, 127 mmol) and aminomethylcyclopropane (5.51 mL, 63.5 mmol) were added dropwise and the reaction mixture was stirred for 4 h.
- 6-Chloropyridine-2-carboxylic acid (1.20 g, 7.62 mmol) and ammonium chloride (0.81 g, 15.2 mmol) were dissolved in DMF (20 mL) and DIPEA (5.31 mL, 30.5 mmol), HONB (2.05 g, 11.4 mmol) and HBTU (4.33 g, 11.4 mmol) were added.
- the reaction mixture was stirred for 1 h and the solvents were removed in vacuo. The residue was partitioned between DCM (50 mL) and 1 M aq HCl (50 mL) and the aq fraction was extracted with DCM (2 ⁇ 25 mL).
- 6-Chloropyridine-2-carboxylic acid (2.00 g, 12.7 mmol), 3,4-diaminopyridine (1.52 g, 14.0 mmol) and DIPEA (2.43 mL, 14.0 mmol) were dissolved in DMF (20 mL) and HBTU (5.29 g, 14.0 mmol) was added.
- the reaction mixture was stirred for 48 h and concentrated in vacuo.
- the residue was dissolved in EtOAc (100 mL), washed with 1 M aq Na 2 CO 3 (2 ⁇ 100 mL), water (100 mL), dried (MgSO 4 ) and concentrated in vacuo.
- the residue was purified by column chromatography, dissolved in AcOH and heated at 120° C.
- Intermediates 120-124 were prepared similarly to Intermediate 119, by reacting 6-(1,4-diazepany-1-yl)-2-substituted pyridines with 4-oxo-piperidine-1-carboxylic acid tert butylester and removing the Boc protecting group; see Table 8 below.
- Intermediates 130-133 were prepared similarly to Intermediate 129, by reductive alkylation of 6-(1,4-diazepany-1-yl)-2-substituted pyridines; see Table 9 below.
- 2-Bromopyridine-6-carboxylic acid (5.00 g, 24.8 mmol) was dissolved in DCM (100 mL) and DMF (1 mL), and oxalyl chloride (7.54 g, 59.4 mmol) was added dropwise over 5 min. The reaction mixture was stirred for 2 h and the solvents were removed in vacuo. The reaction mixture was azeotroped twice with DCM and dissolved in DCM (100 mL).
- N-Boc-hexahydro-1H-azepine-4-one (3.00 g, 14.1 mmol) was dissolved in DCM (50 mL), TFA (15 mL) was added and the reaction mixture was stirred for 2 h. The solvents were removed in vacuo and the residue partitioned between DCM (500 mL) and sat aq Na 2 CO 3 (500 mL). The aq fraction was extracted with DCM (2 ⁇ 250 mL) and the combined organic fractions were dried (MgSO 4 ) and concentrated in vacuo. The residue was dissolved in DCM (50 mL) and acetone (10 mL) and NaBH(OAc) 3 (2.18 g, 141 mmol) were added.
- 6-Chloro-4-methylpyridine-2-carboxylic acid (422 mg, 2.46 mmol) was dissolved in DCM (10 mL) and oxalyl chloride (422 ⁇ L, 4.92 mmol) and DMF (100 ⁇ L) were added. The reaction mixture was stirred for 3 h, the solvents were removed in vacuo and the residue was azeotroped with DCM. The residue was dissolved in DCM (10 mL), DIPEA (1.63 mL, 9.84 mmol) and aminomethylcyclopropane (427 ⁇ L, 4.92 mmol) were added and the reaction mixture was stirred for 1 h.
- Examples 4-58 were prepared similarly to Examples 1-2, by reacting Intermediates 135 and 136 with the appropriate amine; see Table 16 below.
- Examples 60-124 were prepared similarly to Examples 59, by reacting Intermediates 81-88, 90-115 and 117 with the appropriate piperidin-4-one derivative; see Table 17 below.
- Example 125 was prepared similarly to Example 63, using Intermediate 195 instead of Intermediate 81, to give the title compound (12%) as a yellow gum.
- Examples 128-139 were prepared similarly to Example 127, by reacting Intermediates 119-123 with the appropriate aldehyde or ketone; see Table 18 below.
- Examples 141-152 were prepared similarly to Example 140, by reacting Intermediate 135 with the appropriate aniline; see Table 19 below.
- Example 154 was prepared similarly to Example 153, using Intermediate 138 instead of Intermediate 137 and butanoyl chloride instead of acetyl chloride, to give the title compound (8%) as a yellow gum.
- HRMS (ESI+) calculated for C24H38N60; 427.31799, found 427.31772.
- HPLC Rf 4.60 min, 100% purity.
- Examples 155-167 were prepared similarly to Example 153, by reacting Intermediate 137 with the appropriate acyl chloride; see Table 20 below.
- reaction mixture was partitioned between DCM (75 mL) and sat aq Na 2 CO 3 (25 mL) and the organic fraction was washed with brine (25 mL), dried (MgSO 4 ) and concentrated in vacuo.
- Example 170 was prepared similarly to Example 169, using N′-hydroxybenzenecarboximidamide instead of N′-hydroxycyclopropanecarboximidamide, to give the title compound (6%) as a yellow gum.
- HRMS (ESI+) calculated for C26H34N60: 446.27941, found 446.28042.
- HPLC Rf 4.73 min, 98.2% purity.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The compounds of formula (I) are antagonists of the CXCR4 receptor Wherein R1, X, Y and R2 are as defined in the claims.
Description
- This invention relates to compounds that are CXCR4 antagonists, to compositions containing them, to processes for their preparation, and to their use in medicine, in particular for the treatment of conditions which respond to antagonism of the CXCR4 receptor, such as cancer (including cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma), cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, brain inflammation, diabetic retinopathy, age related macular degeneration, and retinal neo-vascularisation and to methods of preventing, treating or ameliorating these conditions. This invention further relates to the use of compounds which are CXCR4 antagonists for use in stem cell apheresis procedures including, for example, promoting release and mobilisation of stem cells, including haematopoietic and non-haematopoietic stem cells and progenitor stem cells, prior to harvesting.
- CXCR4 is a G-protein coupled receptor whose natural endogenous ligand is the cytokine SDF-1 (stromal derived factor-1) or CXCL12. CXCR4 was first discovered as a co-receptor, with CD4, for the entry of T-cell line-tropic (X4) HIV-1 into T-cells. CXCR4 manipulation (in combination with granulocyte colony stimulating factor (G-CSF)) has proven to improve the outcome of haematopoietic (Broxmeyer et al., 2005) and endothelial progenitor cell (Pitchford et al., 2009) stem cell mobilization. The CXCR4-SDF-1 interaction is also a master regulator of cancer stem cell trafficking in the human body (Croker and Allan, 2008) and plays a key role in the progression and metastasis of various types of cancer cells in organs that highly express SDF-1 (Zlotnik, 2008). In view of these important biological functions mediated by CXCR4, small molecule antagonists of the CXCR4 receptor are promising as future therapeutics for stem cell transplantation and for the treatment of diseases such as diabetic retinopathy, cancer, HIV and AIDS.
-
FIG. 1 shows the effect of Example 30 in the attachment of CXCR4-tropic HIV-1 assay. -
FIG. 2 shows the effect of Example 30 in the HIV-1 antiviral assay. -
FIG. 3 shows a significant increase in circulating white blood cells (WBC) 1 hour after treatment with Example 30 when compared to mice in the vehicle control group. -
FIG. 4 shows the evaluation of hematopoietic progenitors following treatment with Example 30 and/or G-CSF. In particular,FIG. 4 shows a significant increase in multipotential mixed hematopoietic progenitors (CFU-GEMM/ml) one hour after treatment with Example 30 in combination with G-CSF when compared to G-CSF treatment alone. - Haematopoietic stem cells or HSCs are widely used in the treatment of cancers of the haematopoietic system e.g. multiple myeloma and non-Hodgkin's lymphoma. Mobilisation and harvesting of HSCs allows the use of cytotoxic drugs to kill the tumour cells within the bone marrow. Subsequently the haematopoietic system can be re-introduced using the previously harvested stem cells.
- Normally stem cells and progenitor cells are attracted to, and retained in, the bone marrow by the action of locally generated SDF-1 on CXCR4 expressed by such cells (see e.g. Lapidot et al., 2005). The stem cells used in transplantation can be mobilised from donors (allogeneic transplantation) or patients (autologous transplantation) after 4 or 5 days treatment with G-CSF. G-CSF is used in approximately 70 percent of the haematopoietic stem cell transplantations (the rest being bone marrow and umbilical cord transplants, Copelan, 2006) and acts by reducing the expression of CXCR4 in stem cells and reducing marrow SDF-1 levels (Levesque et al., 2003). Success in such treatments is based on the success of re-engraftment of the isolated stem cells. Should insufficient stem cells be isolated (<5×106/kg) then the re-engraftment is unlikely to be successful and the patient will not be treated. Multiple days of treatment with G-CSF may only result in sufficient yield in approximately 50% of cases. The CXCR4 antagonist Mozobil is now used to increase the efficiency of mobilisation, resulting in an approximate success rate of 90%. A single administration of CXCR4 antagonist, with a mobilisation delay of only a few hours, we predict will generate sufficient stem cells for effective transplantation (Devine et al., 2008). Such stem cells are we expect to show increased re-engraftment efficiency as they will not have had the expression of this receptor reduced by G-CSF treatment.
- An increase in plasma SDF-1 has been seen in a variety of models including heart infarction (Kucia et al., 2004; Wojakowski et al., 2004), stroke (Kucia et al., 2006), liver damage (Hatch et al., 2002), kidney damage, (Togel et al., 2005), pancreatic damage (Hess et al., 2003), bone fractures (Sata et al., 2005) and lung damage (Gomperts et al., 2006). It is hypothesised that the increase in SDF-1 is caused by the tissue damage and that gradients of this cytokine act to attract the relevant stem cells to the site of injury. This suggests a practical application of stem cell therapeutics for a wide range of injuries, all of which are regulated by the CXCR4/SDF-1 pathway. Interestingly Pitchford et al (2009) showed that different growth factors (VEGF, GCSF) administered with CXCR4 antagonists resulted in the mobilisation of different populations of stem cells, suggesting that appropriate combinations of factors could be used to isolate stem cells for the repair of specific tissues.
- There is a known relationship between CCR5 and HIV (Alkhatib et al., 1996). The CXCR4 and CCR5 receptors act as entry cofactors for HIV infection. In brief, binding of the HIV gp120 protein to CD4 on the surface of CD4+ lymphocytes or macrophages exposes a domain in the gp120 protein which then also binds to the CCR5 or CXCR4 receptor, prior to viral insertion into the plasma membrane. CXCR4 antagonists have been shown to reduce the infectivity of X4 strains of the virus (Fransen et al., 2008), thus suggesting that the use of CXR4 antagonists would be effective treatments of HIV infection, especially in combination with CCR5 antagonists such as Maraviroc. The X4 strain of HIV is the most pathogenic, and these strains tend to predominate in the later stages of infection when neuropathic pain becomes an increasing problem for patients. Painful peripheral neuropathy affects approximately 50% of HIV patients. The HIV gp120 protein binds to CXCR4 and/or CCR5 which are expressed on neuronal and glial cells (Pardo et al, 2001; Oh et al., 2001), causing peripheral axonal damage (Melli et al, 2006) and initiating a cytokine-driven neurotoxic cascade involving glia and immune cells (Herzberg and Sagen, 2001; Milligan et al, 2000, 2001). The highly active anti-retroviral therapy (HAART) can also cause painful neuropathy (Dalakas et al, 2001), but this is predicted to become less common as improved therapies are used.
- Therefore we expect CXCR4 antagonists to show both anti-viral, cognition enhancing and neuropathic pain relieving properties, and could be administered with other anti-(retro)viral therapies as well as analgesics such as amitryptiline, duloxetine and opiates.
- Since the penetration of the blood brain barrier by leukocytes and monocytes is also influenced by the CXCR4 receptor, forms of brain inflammation and neurodegeneration (Bachis et al., J. Neuroscience, 2006, 26, 6771) whether virally induced or not, we expect to be amenable to therapy by CXCR4 antagonists (Kohler et al., 2008; McAndless et al., 2008). Similarly the expression of CXCR4 on primary sensory neurons suggests that antagonists of this receptor could act as analgesics in the control of pain (Oh et al., J Neurosci. 2001 21, 5027-35). In addition the potent chemotactic action of SDF-1 on inflammatory cells (Gouwy et al., Eur J Immunol. 2011 41, 963-73), suggests that CXCR4 antagonists could serve as anti-inflammatory therapeutics.
- Retinal neo-vascularisation is a major cause of blindness in patients with diabetes and age related macular degeneration. The SDF-1/CXCR4 axis is strongly implicated in ocular neo-vascularisation and has been suggested as a target for treating diabetic retinopathy. Blockade of the CXCR4 receptor prevents the recruitment of endothelial progenitor cells, essential for the formation of the new microvessels which are part of the pathology of diabetic retinopathy (Lima e Silva et al., 2009). We expect the effects of CXCR4 antagonists to be additive with those of VEGF antibodies such as avastin. Thus we expect topical or intravitreal administration of CXCR4 antagonist to be an effective treatment of retinal degeneration with diabetes and ageing.
- Several types of cancers (including non-small cell lung, breast and neuroblastoma) express CXCR4, and SDF-1 is highly expressed in internal organs that represent the primary metastatic destinations of the corresponding cancer cells (for review see Ben Baruch, 2008). CXCR4 and SDF-1 are also implicated in the maintenance of cancer stem cells (Wang et al., 2006; Croker and Allan, 2008) and in the recurrence of tumours after radiation therapy. The role of the SDF-1/CXCR4 axis in cancer and cancer stem cells metastasis is discussed in Gelmini S et al., 2008. Blockade of CXCR4 prevented both the vasculogenesis and recurrence of glioblastoma multiforme tumours (Kioi et al., 2010), after radiation treatment. This ability to inhibit tumour derived vasculogenesis leads us to expect that CXCR4 antagonists will be effective when dosed with other anti-angiogenic agents including those that inhibit VEGF (e.g. avastin and aflibercept) and inhibitors of VEGF and PDGFreceptors such as cediranib, sunitinib, sorafenib, pazopanib, tivozanib vatalanib, vandertanib, brivanib, dovitinib, motesanib, telatinib and axitinib (Bhargava and Robinson Curr Oncol Rep (2011) 13:103-111). Other anti-angiogenic agents for use in conjunction with CXCR4 antagonists include those which inhibit EGF, angiopioetins, MMP-9, TNF, bFGF, CXCL8, HGF and TF (Nozawa et al., Proc Natl Acad Sci USA. 103, 12493-12498, 2006; Murdoch et al., Nature Reviews Cancer 8, 618631 2008). Therefore we expect CXCR4 antagonists to be useful in the prevention of metastasis, and in anti-angiogenic treatment, as well as in cancer stem cell protection and maintenance, and in the sensitization of tumours to radiotherapy.
- This invention makes available a class of compounds which are antagonists of the CXCR4 receptor, and their use in indications which respond to the antagonism of the CXCR4 receptor such as those mentioned above.
- According to the present invention there is provided a compound of formula (I) or a pharmaceutically acceptable salt thereof:
- wherein:
R1 is selected from hydrogen, C1-4-alkyl, cyano, —COR5, —CONR3R4 and heteroaryl, wherein -
- (a) said heteroaryl is optionally substituted with one more substituents independently selected from halogen, hydroxy, cyano, nitro, C1-6-alkyl, C3-5-cycloalkyl, C1-4-alkoxy, fluoro-C1-6-alkyl fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl, fluoro-C1-4-alkoxy-C1-4-alkyl, C1-6-aryl, heteroaryl, —NR5AR5B, —C1-4-alkyl-NR5A R5B, —NR4C(O)O—C1-4-alkyl, —NR4C(O)—C1-4-alkyl, —NR4C(O)O-fluoro-C1-4-alkyl, —NR4C(O)-fluoro-C1-4-alkyl, —NR4C(O)NR5AR5B, —C(O)NR5AR5B, —C(O)R4, —C(O)OR4, —NR4S(O)2-C1-4-alkyl and —NR4S(O)2-fluoro-C1-4-alkyl, and
- (b) said C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy;
X is selected from radicals of formulae (A)-(F) inclusive, any of which being optionally substituted with one more substituents independently selected from halogen, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl and fluoro-C1-4-alkoxy, wherein the bond marked * is attached to R1 and the bond marked ** is attached to Y:
- Y is selected from radicals of formulae (H), (J), (K), (L) and (M) any of which is optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, a divalent C1-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, C1-4-alkoxy, fluoro-C1-4-alkyl, a divalent fluoro-C1-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine and fluoro-C1-4-alkoxy, wherein the bond marked * is attached to X and the bond marked ** is attached to R2:
- and n and m are each independently 1 or 2, and R20 is hydrogen, or C1-4-alkyl;
R2 is selected from radicals of formulae (N)-(S) inclusive, any of which is optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl and fluoro-C1-4-alkoxy, wherein the bond marked * is attached to Y: - and o and p are each independently 1 or 2, and W is O or NR9;
R3 is selected from hydrogen, C1-6-alkyl, C3-5cycloalkyl, C3-5-cycloalkyl-C1-4-alkyl, heterocyclyl, heterocyclyl-C1-4 heteroaryl, C6-10-alkyl, C6-10-aryl, aryl-C1-4-alkyl and heteroaryl-C1-4-alkyl, wherein -
- (i) said C1-6-alkyl, C3-5-cycloalkyl, heterocyclyl or the heterocyclyl part of said heterocyclyl-C1-4-alkyl, or the C1-6-alkyl part of said heterocyclyl-C1-4-alkyl, C6-10-aryl-C1-4-alkyl or heteroaryl-C1-4-alkyl, is optionally substituted with one or more substituents independently selected from fluorine, hydroxy, C1-4-alkoxy and —NR5AR5B, and
- (ii) said C6-10-aryl or heteroaryl, or the C6-10-aryl part of said C6-10-aryl-C1-4-alkyl or the heteroaryl part of said heteroaryl-C1-4-alkyl, is optionally substituted with one more substituents independently selected from halogen, hydroxy, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl, fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl, fluoro-C1-4-alkoxy-C1-4-alkyl, —NR5AR5B, —C1-4-alkyl-NR5AR5B, —NR4C(O)O—C1-4alkyl, —NR4C(O)—C1-4alkyl, —NR4C(O)O-fluoro-C1-4 alkyl, —NR4C(O)-fluoro-C1-4alkyl, —NR4C(O)NR5AR5B, —C(O)NR5AR5B, —C(O)R4, —C(O)OR4, —NR4S(O)2—C1-4alkyl and —NR4S(O)2-fluoro-C1-4alkyl;
R4, R5A and R5B are each independently selected from hydrogen, C1-4-alkyl and fluoro-C1-4-alkyl, or
R5A and R5B together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring or a heteroaryl ring, said ring being optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl and C1-4-alkoxy, or
R3 and R4, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring or a heteroaryl ring, said ring being optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl and C1-4-alkoxy; and
R6 is selected from C1-6-alkyl, C3-5-cycloalkyl, C3-5-cycloalkyl-C1-4-alkyl, heterocyclyl, heterocyclyl-C1-4-alkyl, C6-10-aryl-C1-4-alkyl and C6-10-aryl, wherein - (iii) said C1-6-alkyl, C3-5-cycloalkyl, heterocyclyl, or the C1-6-alkyl part of said heterocyclyl-C1-4-alkyl or C6-10-aryl-C1-4-alkyl, or the heterocyclyl part of said heterocyclyl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy, and
- (iv) said C6-10-aryl or the C6-10-aryl part of said C6-10-aryl-C1-4-alkyl is optionally substituted with one more substituents independently selected from halogen, hydroxy, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl, fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl and fluoro-C1-4-alkoxy-C1-4-alkyl;
R7 is selected from C1-6-alkyl, C3-5-cycloalkyl, C3-5-cycloalkyl-C1-4-alkyl, heterocyclyl, heterocyclyl-C1-4-alkyl, C6-10-aryl-C1-4-alkyl and C6-10-aryl and NR10AR10B wherein - (v) said C1-6-alkyl, C3-5-cycloalkyl, heterocyclyl, or the C1-6-alkyl part of said heterocyclyl-C1-4-alkyl or C6-10-aryl-C1-4-alkyl, or the heterocyclyl part of said heterocyclyl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy, and
- (vi) said C6-10-aryl or the C6-10-aryl part of said C6-10-aryl-C1-4-alkyl is optionally substituted with one more substituents independently selected from halogen, hydroxy, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl, fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl and fluoro-C1-4-alkoxy-C1-4-alkyl;
R8A, R8B and R9 are each independently selected from hydrogen, C3-5-cycloalkyl, C1-6-alkyl, and C6-10-aryl-C1-4-alkyl wherein any alkyl residue or cycloalkyl or C6-10-aryl ring system is optionally substituted with one or more substituents independently selected from halogen, hydroxyl and C1-4-alkoxy, or
R8A and R8B, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring which is optionally fused to a C6-10-aryl or heteroaryl ring system, the 4- to 7-membered saturated heterocyclic ring or the C6-10-aryl or heteroaryl ring systems being optionally substituted with one or more substituents independently selected from halogen, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl and C1-4-alkoxy; and
R10A and R10B are each independently selected from hydrogen and C1-6-alkyl, wherein said C1-6-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy, or
R10A and R10B, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring or a heteroaryl ring, optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl and C1-4-alkoxy; provided that when Y is a piperazine of formula (H) wherein n=1, then R1 is not piperidine wherein p=1, and o=2; and
when Y is a piperazine of formula (H) wherein n=1 then R1 is not an alkyl amino of formula (S).
- Compounds of formula (I) above may be prepared in the form of salts, especially pharmaceutically acceptable salts, N-oxides, hydrates, solvates and polymorphic forms thereof. Any claim to a compound herein, or reference herein to “compounds of the invention”, “compounds with which the invention is concerned”, “compounds of formula (I)” and the like, includes salts, N-oxides, hydrates, solvates and polymorphs of such compounds;
- Although the above definition potentially includes molecules of high molecular weight, it is preferable, in line with general principles of medicinal chemistry practice, that the compounds with which this invention is concerned should have molecular weights of no more than 600.
- The compounds of the invention are antagonists of the CXCR4 receptor. Therefore, in another broad aspect the invention provides the use of a compound of the invention in the treatment of, or in the preparation of a composition for treatment of, diseases or conditions responsive to the reduction of CXCR4 mediated activity.
- Examples of diseases or conditions which are responsive to the reduction of CXCR4 mediated activity include cancer including cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma, cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, pain, inflammation, brain inflammation, neurodegeration, cognative degeneration, diabetic retinopathy, age related macular degeneration, retinal neo-vascularisation, and viral infections.
- The compounds with which the invention is concerned may be used for the reduction of CXCR4 mediated activity, ex vivo or in vivo.
- In one aspect of the invention, the compounds of the invention may be used in the preparation of a composition for the treatment of cancer including cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma, non-small cell lung, breast and neuroblastoma, cancer metastasis, HIV/AIDS, neuropathy, HIV related neuropathy, pain, inflammation, brain inflammation, neurodegeration, cognative degeneration, diabetic retinopathy, age related macular degeneration, retinal neo-vascularisation, and viral infections.
- In another aspect, the invention provides a method for the treatment of the foregoing disease types, which comprises administering to a subject suffering such disease an effective amount of a compound of the invention.
- In another aspect, the compounds of the invention may be used for stem cell apheresis including haematopoietic stem cell mobilisation and non-haematopoietic stem and progenitor cell mobilization. Apheresis in its broadest meaning is a procedure in which blood is drawn and separated into its components, for example by dialysis; some components are retained and the rest are used for further medical procedures such as being returned to the donor or another subject by transfusion. Thus, apheresis may be applied, for example, to harvest stem cells from plasma for subsequent use in stem cell transplantation. A further example of a therapeutic application of stem cell apheresis is in reducing leukopenia which would otherwise be a consequence of chemotherapy or radiotherapy. Stem cells are damaged during chemo- or radiotherapy, and stem cell apheresis may be used to harvest stem cells from the body prior to such treatment, and then returned undamaged to the body once the radio- or chemotherapy is finished.
- In another aspect, the apheresis procedure may be implemented prior to treatment of a subject by chemotherapy or radiotherapy, in order to reduce chemotherapy- or radiotherapy-induced leukopenia.
- In another aspect, the compounds of the invention may be administered as an adjunct to chemotherapy or radiotherapy to sensitize tumours to such chemotherapy or radiotherapy.
- In another aspect, the compounds of the invention may be used for inhibition of neo-vascularisation, angiogenesis, or vasculogenesis.
- In another aspect of the invention, there is provided a pharmaceutical composition comprising a compound of the invention together with one or more pharmaceutically acceptable carriers and/or excipients.
- In another aspect, there is provided a pharmaceutical composition comprising a compound of the invention together with one or more anti-angiogenic agents. In one embodiment the anti-angiogenic agent is an inhibitor of the VEGF receptor. In another embodiment the anti-angiogenic agent is an inhibitor of the PDGF receptor. In another embodiment the anti-angiogenic agent is selected from cediranib, sunitinib, sorafenib, pazopanib, tivozanib vatalanib, vandertanib, brivanib, dovitinib, motesanib, telatinib and axitinib.
- The compounds of the invention may be administered in a variety of dosage forms. Thus, they can be administered orally, for example as tablets, capsules, troches, lozenges, aqueous or oily suspensions, dispersible powders or granules. The compounds can be administered in a sublingual formulation, for example a buccal formulation. The compounds of the invention may also be administered parenterally, whether subcutaneously, intravenously, intramuscularly, intrasternally, transdermally, by inhalation, intranasally, or by infusion techniques. The compounds may also be administered as suppositories. Thus, the compounds of the invention are administered orally, or by inhalation, or intranasally, but preferably the compounds of the invention are administered orally and more preferably, the compounds of the invention are administered as a tablet or capsule.
- In the latter connection, administration of the compounds in a hard gelatine capsule form, or in one of the many sustained release formulations known in the art will often be preferred.
- The compounds of the invention are typically formulated for administration with a pharmaceutically acceptable carrier or diluent. For example, solid oral forms may contain, together with the active compound, diluents, e.g. lactose, dextrose, saccharose, cellulose, corn starch or potato starch; lubricants, e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents; e.g. starches, arabic gums, gelatin, methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disaggregating agents, e.g. starch, alginic acid, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents, such as lecithin, polysorbates, laurylsulphates; and, in general, non toxic and pharmacologically inactive substances used in pharmaceutical formulations. Such pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tableting, sugar coating, or film coating processes.
- Liquid dispersions for oral administration may be syrups, emulsions and suspensions. The syrups may contain as carriers, for example, saccharose or saccharose with glycerine and/or mannitol and/or sorbitol. Suspensions and emulsions may contain as carrier, for example a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or polyvinyl alcohol. The suspension or solutions for intramuscular injections may contain, together with the active compound, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and if desired, a suitable amount of lidocaine hydrochloride.
- Since the compounds of the invention are preferably administered orally, the present invention further provides a pharmaceutical composition containing a compound of the invention or a pharmaceutically acceptable salt thereof, as defined above, and a pharmaceutically acceptable carrier in the form of a capsule or tablet.
- Solutions for injection or infusion may contain as carrier, for example, sterile water or preferably they may be in the form of sterile, aqueous, isotonic saline solutions.
- It will be understood that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed, the age, body weight, general health, sex, diet, time of administration, route of administration, rate of excretion, drug combination and the severity of the particular disease undergoing treatment. Optimum dose levels and frequency of dosing will be determined by clinical trial, as is required in the art. However, it is expected that a typical dose will be in the range from about 0.001 to 50 mg per kg of body weight.
- The following definitions shall apply throughout the specification and the appended claims, unless otherwise stated or indicated.
- Where elements present in the compounds of the invention exist as different isotopes, for example carbon (C13 and C14) nitrogen (N14 and N15) and hydrogen (H1 and H2 ie deuterium), such compounds form part of the invention irrespective of the isotopic form of the element present in the compound. In particular, where a compound of the invention has a hydrogen atom in any position, that hydrogen may be replaced by deuterium. It is known in the art that deuterium substitution can increase the metabolic stability of biologically active molecules. The term “halogen” denotes a fluoro, chloro, bromo or iodo substituent. In a presently preferred embodiment halogen is fluoro or chloro.
- The term “Ca-b,-alkyl” wherein a and b are integers denotes a straight or branched alkyl group having from a to b carbon atoms. For example “C1-4-alkyl” includes methyl, ethyl, n-propyl, isopropyl, n-butyl, iso-butyl, sec-butyl and tert-butyl and “C1-6-alkyl” includes the foregoing and straight- and branched-chain pentyl and hexyl.
- The term “fluoro-Ca-b,-alkyl” wherein a and b are integers denotes a straight or branched Ca-b-alkyl group substituted by one or more fluorine atoms. For example fluoro-C1-4-alkyl includes fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl.
- The term “Ca-b-alkoxy” wherein a and b are integers refers to a straight or branched Ca-b-alkyl group which is attached to the remainder of the molecule through an oxygen atom. For example C1-4-alkoxy includes methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy.
- The term “fluoro-Ca-b-alkoxy” wherein a and b are integers denotes a fluoro-Ca-b-alkyl group which is attached to the remainder of the molecule through an oxygen atom. For example “fluoro-C1-4-alkoxy” groups include trifluoromethoxy and 2,2,2-trifluoroethoxy.
- The term “Ca-b,-alkoxy-Cc-d-alkyl” wherein a, b, c and d are integers denotes a straight or branched alkoxy group having from a to b carbon atoms connected to a straight or branched alkyl group having from c to d carbon atoms. For example “C1-4-alkoxy-C1-4-alkyl” includes methoxymethyl, methoxyethyl, ethoxyethyl, iso-propoxyethyl, n-butoxyethyl and tert-butoxyethyl. In an alternative example “C1-2-alkoxy-C1-4-alkyl” includes methoxymethyl, methoxyethyl, and ethoxyethyl.
- The term fluoro-Ca-b-alkoxy-Cc-d-alkyl wherein a, b, c and d are integers denotes a Ca-b-alkoxy-Cc-d-alkyl group substituted by one or more fluorine atoms. For example “fluoro-C1-4-alkoxy-C1-4-alkyl” includes trifluoromethoxymethyl and trifluoromethoxyethyl.
- The term “Ca-b-cycloalkyl” wherein a and b are integers denotes a saturated monocyclic hydrocarbon ring having from a to b carbon atoms. For examples “C3-5-cycloalkyl” includes cyclopropyl, cyclobutyl and cyclopentyl. The term “C3-5-cycloalkyl” also includes a cyclopropyl, cyclobutyl or cyclopentyl ring system which is fused to a C6-10-aryl group such as phenyl.
- The term “Ca-b-cycloalkyl-Cc-d-alkyl” wherein a, b, c and d are integers denotes a saturated monocyclic hydrocarbon ring having from a to b carbon atoms connected to a straight or branched alkyl group having from c to d carbon atoms. For example “C3-5-cycloalkyl-C1-4-alkyl” includes cyclopropylmethyl and cyclobutylmethyl.
- Unless otherwise particularised, the term “heterocyclyl” or “heterocyclic ring” denotes a saturated, monocyclic ring having from 4 to 7 ring atoms with at least one heteroatom such as O, N, or S, and the remaining ring atoms are carbon. Examples of heterocyclic rings include piperidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, azetidinyl, pyrrolidinyl, morpholinyl, thiomorpholinyl, dioxanyl, piperazinyl and homopiperazinyl. When present, the sulfur atom may be in an oxidized form (i.e., S═O or O═S═O). Exemplary heterocyclic groups containing sulfur in oxidized form are 1,1-dioxido-thiomorpholinyl and 1,1-dioxido-isothiazolidinyl. The term “heterocyclyl” or “heterocyclic ring” also includes a ring system in which the “heterocyclyl” or “heterocyclic ring” is fused to a C6-10-aryl ring system, such as phenyl.
- Unless otherwise particularised the term “heterocyclyl-Cab-alkyl” wherein a and b are integers denotes a heterocyclic ring as defined above that is directly attached to a straight or branched Ca-b-alkyl group via a carbon or nitrogen atom of said ring. For example “heterocyclyl-C1-4-alkyl” groups include piperidin-1-ylmethyl, piperidin-4-ylmethyl and morpholin-4-ylmethyl.
- Unless otherwise particularised the term “heteroaryl” denotes a monocyclic or fused bicyclic heteroaromatic ring system comprising 5 to 10 ring atoms in which one or more of the ring atoms are other than carbon, such as nitrogen, sulphur or oxygen. Only one ring need to be aromatic and said heteroaryl moiety can be linked to the remainder of the molecule via a carbon or nitrogen atom in any ring. Examples of heteroaryl groups include furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, imidazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, quinazolinyl, indolyl, indolinyl, isoindolyl, isoindolinyl, pyrazolyl, pyridazinyl, pyrazinyl, quinolinyl, quinoxalinyl, oxadiazolyl, thiadiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 1,3-benzodioxolyl, 1,4-benzodioxinyl, benzothiazolyl, benzimidazolyl, azabenzimidazole, benzotriazolyl and chromanyl.
- Unless otherwise particularised the term “Ca-b-aryl” wherein a and b are integers denotes a monocyclic or fused bicyclic hydrocarbon ring system comprising a to b ring atoms and wherein at least one ring is an aromatic ring. For example “C6-10-aryl” groups include phenyl, indenyl, 2,3-dihydroindenyl (indanyl), 1-naphthyl, 2-naphthyl or 1,2,3,4-tetrahydronaphthyl.
- Unless otherwise particularised the term “Cab-aryl-Cc-d-alkyl” wherein a, b, c and d are integers refers to a Ca-b-aryl group that is directly linked to a straight or branched Cc-d-alkyl group. For example “C6-10-aryl-C1-4-alkyrgroups include phenylmethyl (i.e., benzyl) and phenylethyl.
- Unless otherwise particularised the term “heteroaryl-Ca-b-alkyl” wherein a and b are integers denotes a heteroaryl ring as defined above that is directly linked to a straight or branched Cab alkyl group via a carbon or nitrogen atom of said ring. For examples “heteroaryl-C1-4-alkyl” groups include 2-(pyridin-2-yl)-ethyl and 1,2,4-oxadiazol-5-ylmethyl.
- Compounds of the invention may exist in one or more geometrical, optical, enantiomeric, diastereomeric and tautomeric forms, including but not limited to cis- and trans-forms, E- and Z-forms, R-, S- and I-forms, keto-, and enol-forms. Unless otherwise stated a reference to a particular compound includes all such isomeric forms, including racemic and other mixtures thereof. Where appropriate such isomers can be separated from their mixtures by the application or adaptation of known methods (e.g. chromatographic techniques and recrystallisation techniques). Where appropriate such isomers may be prepared by the application of adaptation of known methods (e.g. asymmetric synthesis).
- As used herein the term “salt” includes base addition, acid addition and ammonium salts. As briefly mentioned above compounds of the invention which are acidic can form salts, including pharmaceutically acceptable salts, with bases such as alkali metal hydroxides, e.g. sodium and potassium hydroxides; alkaline earth metal hydroxides e.g. calcium, barium and magnesium hydroxides; with organic bases e.g. N-methyl-D-glucamine, choline tris(hydroxymethyl)amino-methane, L-arginine, L-lysine, N-ethyl piperidine, dibenzylamine and the like. Those compounds of the invention which are basic can form salts, including pharmaceutically acceptable salts with inorganic acids, e.g. with hydrohalic acids such as hydrochloric or hydrobromic acids, sulphuric acid, nitric acid or phosphoric acid and the like, and with organic acids e.g. with acetic, trifluoroacetic, tartaric, succinic, fumaric, maleic, malic, salicylic, citric, methanesulphonic, p-toluenesulphonic, benzoic, benzenesulfonic, glutamic, lactic, and mandelic acids and the like. Those compounds (I) which have a basic nitrogen can also form quaternary ammonium salts with a pharmaceutically acceptable counter-ion such as chloride, bromide, acetate, formate, p-toluenesulfonate, succinate, hemi-succinate, naphthalene-bis sulfonate, methanesulfonate, trifluoroacetate, xinafoate, and the like. For a review on salts, see Handbook of Pharmaceutical Salts: Properties, Selection, and Use by Stahl and Wermuth (Wiley-VCH, Weinheim, Germany, 2002).
- It is expected that compounds of the invention may be prepared in the form of hydrates, and solvates. Any reference herein, including the claims herein, to “compounds with which the invention is concerned” or “compounds of the invention” or “the present compounds”, and the like, includes reference to salts, hydrates, and solvates of such compounds. The term ‘solvate’ is used herein to describe a molecular complex comprising the compound of the invention and a stoichiometric amount of one or more pharmaceutically acceptable solvent molecules, for example, ethanol. The term ‘hydrate’ is employed when said solvent is water.
- Individual compounds of the invention may exist in an amorphous form and/or several polymorphic forms and may be obtained in different crystal habits. Any reference herein, including the claims herein, to “compounds with which the invention is concerned” or “compounds of the invention” or “the present compounds”, and the like, includes reference to the compounds irrespective of amorphous or polymorphic form.
- Some compounds of the invention, having a nitrogen atom in an aromatic ring, may form N-oxides, and the invention includes compounds of the invention in their N-oxide form.
- In the compounds of the invention, in any compatible combination, and bearing in mind that the compounds preferably have a molecular weight of less than 600:
- The group R1
- As defined above, R1 is selected from hydrogen, C1-4-alky such as methyl, ethyl, n- or isopropyl, n-, sec- or tert-butyl, cyano, —CONR3, —CONR3R4 and heteroaryl such as furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, imidazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, quinazolinyl, indolyl, indolinyl, isoindolyl, isoindolinyl, pyrazolyl, pyridazinyl, pyrazinyl, quinolinyl, quinoxalinyl, oxadiazolyl, thiadiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 1,3-benzodioxolyl, 1,4-benzodioxinyl, benzothiazolyl, benzimidazolyl, benzotriazolyl and chromanyl, wherein
-
- (a) said heteroaryl is optionally substituted with one more substituents independently selected from halogen such as fluoro, chloro, bromo, hydroxy, cyano, nitro, C1-6-alkyl such as methyl, ethyl, n- or iso-propyl, n-butyl, isobutyl, sec-butyl and t-butyl, and straight or branched pentyl or hexyl, C3-5-cycloalkyl such as cyclopropyl, cyclobutyl and cyclopentyl, C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C1-6-alkyl such as mono-, di- or tri-fluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, fluoro-C1-4-alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy, C1-4-alkoxy-C1-4-alkyl such as methoxymethyl, methoxyethyl, ethoxyethyl, isopropoxyethyl, n-butoxyethyl and tert-butoxyethyl, fluoro-C1-4-alkoxy-C1-4-alkyl such as trifluoromethoxymethyl and trifluoromethoxyethyl, C6-10-aryl such as phenyl, indenyl, 2,3-dihydroindenyl (indanyl), 1-naphthyl, 2-naphthyl or 1,2,3,4-tetrahydronaphthyl, heteroaryl such as such as furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, imidazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, quinazolinyl, indolyl, indolinyl, isoindolyl, isoindolinyl, pyrazolyl, pyridazinyl, pyrazinyl, quinolinyl, quinoxalinyl, oxadiazolyl, thiadiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 1,3-benzodioxolyl, 1,4-benzodioxinyl, benzothiazolyl, benzimidazolyl, benzotriazolyl and chromanyl, —NR5AR5B, —C1-4-alkyl-NR5AR5B NR4C(O)O—C1-4-alkyl, —NR4C(O)—C1-4-alkyl, —NR4C(O)O-fluoro-C1-4-alkyl, —NR4C(O)-fluoro-C1-4-alkyl, —NR4C(O)NR5AR5B, —C(O)NR5AR5B, —C(O)R4, —C(O)OR4, —NR4S(O)2—C1-4-alkyl and —NR4S(O)2-fluoro-C1-4-alkyl, and
- (b) said C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy;
- As defined above, X is selected from radicals of formulae (A), (B), (C), (D), (E), or (F) inclusive, any of which being optionally substituted with one more substituents independently selected from halogen such as fluoro, chloro, bromo, cyano, nitro, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, and fluoro-C1-4-alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy,
- As defined above, Y is selected from radicals of formulae (H) such as piperazine and homopiperazine, (J) such as amino-piperidine and amino-homopiperidine, (K) such as amino-piperidine and amino-homopiperidine, (L) such as 1,2-diaminoethane and 1,3-diamino propane, and (M) such as oxy-piperidine, any of which is optionally substituted with one more substituents independently selected from, fluorine, hydroxyl, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl a divalent C1-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, examples include —CH2—, —CH2CH2— and —CH2CH2CH2—, C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, a divalent fluoro-C1-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, examples include —CH2—, —CH2CH2— and —CH2CH2CH2— wherein one or more hydrogens are replaced by fluorine, and fluoro-C1-4-alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy.
- As defined above, R2 is selected from radicals of formulae (N), (0), (P), (Q), (R), and (S) inclusive, any of which is optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl and fluoro-C1-4-alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy,
- As defined above, R3 is selected from hydrogen, C1-6-alkyl such as methyl, ethyl, n- or isopropyl, n-butyl, isobutyl, sec-butyl and tert-butyl, straight or branched pentyl and hexyl, C3-5-cycloalkyl such as cyclopropyl, cyclobutyl and cyclopentyl, C3-5-cycloalkyl-C1-4-alkyl such as cyclopropylmethyl and cyclobutylmethyl, heterocyclyl such as piperidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, azetidinyl, pyrrolidinyl, morpholinyl, imidazolidinyl, thiomorpholinyl, dioxanyl, piperazinyl, homopiperazinyl, 1-dioxido-thiomorpholinyl and 1,1-dioxido-isothiazolidinyl, heterocyclyl-C1-4-alkyl such as piperidin-1-ylmethyl, piperidin-4-ylmethyl and morpholin-4-ylmethyl, C6-10-aryl such as phenyl, indenyl, 2,3-dihydroindenyl (indanyl), 1-naphthyl, 2-naphthyl or 1,2,3,4-tetrahydronaphthyl, C6-10-aryl-C1-4-alkyl such as phenylmethyl (i.e., benzyl) and phenylethyl, heteroaryl such as furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, imidazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, tetrazolyl, quinazolinyl, indolyl, indolinyl, isoindolyl, isoindolinyl, pyrazolyl, pyridazinyl, pyrazinyl, quinolinyl, quinoxalinyl, oxadiazolyl, thiadiazolyl, benzofuranyl, 2,3-dihydrobenzofuranyl, 1,3-benzodioxolyl, 1,4-benzodioxinyl, benzothiazolyl, benzimidazolyl, benzotriazolyl and chromanyl, and heteroaryl-C1-4-alkyl such as 2-(pyridin-2-yl)-ethyl and 1,2,4-oxadiazol-5-ylmethyl, wherein
-
- (i) said C1-6-alkyl, C3-5-cycloalkyl, heterocyclyl or the heterocyclyl part of said heterocyclyl-C1-4-alkyl, or the C1-6-alkyl part of said heterocyclyl-C1-4-alkyl, C6-10-aryl-C1-4-alkyl or heteroaryl-C1-4-alkyl, is optionally substituted with one or more substituents independently selected from fluorine, hydroxy, C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, and —NR5AR5B, and
- (ii) said C6-10-aryl or heteroaryl, or the C6-10-aryl part of said C6-10-aryl-C1-4-alkyl or the heteroaryl part of said heteroaryl-C1-4-alkyl, is optionally substituted with one more substituents independently selected from halogen such as fluoro, chloro or bromo, hydroxy, cyano, nitro, C1-4-alkyl- such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, fluoro-C1-4-alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy, C1-4-alkoxy-C1-4-alkyl such as methoxymethyl, methoxyethyl, ethoxyethyl, iso-propoxyethyl, n-butoxyethyl and t-butoxyethyl, fluoro-C1-4-alkoxy-C1-4-alkyl such as trifluoromethoxymethyl and trifluoromethoxyethyl, —NR5AR5B, C1-4-alkyl-NR5AR5B, NR4C(O)—C1-4 alkyl, —NR4C(O)O-fluoro-C1-4alkyl, —NR4C(O)-fluoro-C1-4alkyl, —NR4C(O)NR5AR5B, —C(O)NR5AR5B, —C(O)R4, —C(O)OR4, —NR4S(O)2—C1-4alkyl and —NR4S(O)2-fluoro-C1-4alkyl;
The Groups R4, R5A and R5B
- As defined above, R4, R5A and R5B are each independently selected from hydrogen, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, and fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, or
- R3 and R4, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring such as pyrrolidine, piperidine, homopiperidine, piperazine, homopiperazine and morpholine, or a heteroaryl ring such as pyrrole, imidazole, indole, isoindole, indazole, or purine, said ring being optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy
- As defined above, R6 is selected from C1-6-alkyl such as methyl, ethyl, n- or iso-propyl, n-butyl, isobutyl, sec-butyl and tert-butyl, and straight or branched pentyl and hexyl, C3-5-cycloalkyl such as cyclopropyl, cyclobutyl and cyclopentyl, C3-5-cycloalkyl-C1-4-alkyl such as cyclopropylmethyl and cyclobutylmethyl, heterocyclyl such as piperidinyl, tetrahydropyranyl, tetrahydrofuranyl, oxetanyl, azetidinyl, pyrrolidinyl, morpholinyl, imidazolidinyl, thiomorpholinyl, dioxanyl, piperazinyl,
homopiperazinyl 1,1-dioxido-thiomorpholinyl and 1,1-dioxido-isothiazolidinyl, heterocyclyl-C1-4-alkyl such as piperidin-1-ylmethyl, piperidin-4-ylmethyl and morpholin-4-ylmethyl, C6-10-aryl such as phenyl, indenyl, 2,3-dihydroindenyl (indanyl), 1-naphthyl, 2-naphthyl or 1,2,3,4-tetrahydronaphthyl, heteroaryl, and C6-10-aryl-C1-4-alkyl such as phenylmethyl (i.e., benzyl) and phenylethyl, wherein -
- (iii) said C1-6-alkyl, C3-5-cycloalkyl, heterocyclyl, or the C1-6-alkyl part of said heterocyclyl-C1-4-alkyl or C6-10-aryl-C1-4-alkyl, or the heterocyclyl part of said heterocyclyl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, and
- (iv) said C6-10-aryl or the C6-10-aryl part of said C6-10-aryl-C1-4-alkyl is optionally substituted with one more substituents independently selected from halogen including fluoro or chloro, hydroxy, cyano, nitro, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, iso-propoxy, n-butoxy, iso-butoxy, sec-butoxy and tert-butoxy, fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl, fluoro-C1-4-alkoxy such as trifluoromethoxy and 2,2,2-trifluoroethoxy, C1-4-alkoxy-C1-4-alkyl such as methoxymethyl, methoxyethyl, ethoxyethyl, isopropoxyethyl, n-butoxyethyl and t-butoxyethyl, and fluoro-C1-4-alkoxy-C1-4-alkyl such as trifluoromethoxymethyl and trifluoromethoxyethyl;
The Groups R8A, R8B and R9
- As defined above, R8A, R8B and R9 are each independently selected from hydrogen, C3-5-cycloalkyl such as cyclopropyl or cyclobutyl or cyclopentyl, C6-10aryl-C1-4alkyl such as phenyl methyl (benzyl) and C1-6-alkyl such as methyl, ethyl, n- or iso-propyl, n-butyl, isobutyl, sec-butyl and t-butyl, and straight or branched pentyl and hexyl, wherein any alkyl residue is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, or
- R8A and R8B, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring such as pyrrolidine, piperidine homopiperidine, piperazine, homopiperazine and morpholine, optionally substituted with one or more substituents independently selected from halogen such as fluoro or chloro, hydroxyl, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, fluoro-C1-4-alkyl and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy or the 4-7 membered saturated heterocyclic ring is optionally fused to a C6-10aryl or heteroaryl ring system, the 4-7 membered saturated heterocyclic ring or the C6-10aryl being optionally substituted with with one or more substituents independently selected from halogen such as fluoro or chloro, hydroxyl, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, fluoro-C1-4-alkyl and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy;
- The Groups R10A and R10B As defined above, R10A and R10B are each independently selected from hydrogen and C1-6-alkyl such as methyl, ethyl, n- or iso-propyl, n-butyl, isobutyl, sec-butyl and t-butyl, straight or branched pentyl and hexyl, wherein said C1-6-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy, or
- R10A and R10B, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring ring such as pyrrolidine, piperidine homopiperidine, piperazine, homopiperazine and morpholine or a heteroaryl ring such as pyrrole, imidazole, indole, isoindole, indazole, and purine, optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl such as methyl, ethyl, n- or iso-propyl, n-, sec- or tert-butyl, fluoro-C1-4-alkyl such as fluoromethyl, trifluoromethyl, 2-fluoroethyl and 2,2,2-trifluoroethyl and C1-4-alkoxy such as methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, isobutoxy, sec-butoxy and tert-butoxy.
- In a presently preferred embodiment of the invention R1 is CONR3R4 or heteroaryl such as benzoxazolyl, indolyl, azaindolyl, imidazolyl, benzimidazolyl, oxazolyl, oxadiazolyl or tetrazolyl, any of which may be optionally substituted with one or more substituents independently selected from, for example, halogen such as fluoro, chloro, cyano, C1-6-alkyl such as methyl, ethyl, propyl, iso-propyl, tert-butyl, n-butyl, C3-5-cycloalkyl such as cyclopropyl, cyclopentyl, C1-4-alkoxy such as methoxy, fluoro-C1-6-alkyl such as trifluoromethyl, fluoro-C1-4-alkoxy, and heteroaryl such as pyridyl.
- In an alternative presently preferred embodiment of the invention R1 is CONR3R4 wherein R4 is hydrogen or methyl and R3 is selected from tetrahydropyranyl, isopropylmethyl, tetrahydropyranylmethyl, imidazolylethyl, methoxyethyl, N-methylimidazolylmethyl, tetrahydrofuranylmethyl, 1-fluoroethyl, oxazolylmethyl, pyridylmethyl, 2,2-difluoromethyl, tetrahydrofuranyl, methyl, ethyl, n- or iso-propyl, n-sec- or tert-butyl, cyclopropyl, hydroxyethyl, cyanoethyl, phenyl, pyridyl, chlorophenyl, methoxyphenyl, methylphenyl, hydroxyphenyl, thiazoloylmethyl, indolyl, methoxypropyl, tetrahydroisoquinolinyl, furylmethylpyridylethyl, thiazolyl, cyclopropylmethyl. In a preferred embodiment any one of the R3 substituents are optionally substituted with one or more optional substituents such as halogen or C1-4 alkyl.
- In a presently preferred embodiment of the invention X is a 2,6-pyridyl radical of formula (A).
- In an alternative presently preferred embodiment of the invention Y is a homopiperazinyl radical of formula (H) when n is 2, or a piperazine radical of formula (H) when n is 1, either of which being optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl such as methyl, a divalent C1-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine such as —CH2CH2— or —CH2CH2CH2—, C1-4-alkoxy such as methoxy, fluoro-C1-4-alkyl such as di- and trifluoromethyl, or a divalent fluoro-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, and fluoro-C1-4-alkoxy such as mono-, di-, and tri-fluoromethoxy.
- In a yet further presently preferred embodiment of the invention Y is a homopiperazinyl radical of formula (H) when n is 2, or a piperazine radical of formula (H) when n is 1, either of which being optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl such as methyl, a divalent C1-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine such as -ethylene- or -propylene-, C1-4-alkoxy such as methoxy, fluoro-C1-4-alkyl such as di- and trifluoromethyl, or a divalent fluoro-C1-4-alkylene radical which forms a bridge between ring carbons of said homopiperazine or piperazine, and fluoro-C1-4-alkoxy such as mono-, di-, and tri-fluoromethoxy, and R2 is selected from a 4-piperidine radical of formula (N) wherein o is 2 and p is 1, a 1,4-cyclohexyl radical of formula (R) or a —CH2morpholin-3-yl radical of formula (Q) wherein w is O, and wherein said 4-piperidine, and said 1,4-cyclohexyl and said —CH2morphilin-3-yl radicals are optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl such as methyl, ethyl, C1-4-alkoxy such as methoxy, fluoro-C1-4-alkyl such as mono-, di-, and tri-fluoromethyl, and fluoro-C1-4-alkoxy such as mono, di-, and tri-fluoromethoxy.
- In an alternative presently preferred embodiment of the invention Y is a piperazine radical of formula (H) wherein n is 1, optionally substituted as defined above, and R2 is a 4-azepine radical of formula (N) wherein 0 is 2 and p is 2, said 4-azepine radical being optionally substituted with one more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl such as methyl, C1-4-alkoxy such as methoxy, fluoro-C1-4-alkyl such as trifluoromethyl, and fluoro-C1-4-alkoxy.
- In a preferred embodiment R3 is pyridyl optionally substituted with one or more substituents selected from halogen such as fluoro or chloro, C1-4-alkyl such as methyl or ethyl or isopropyl, C1-4-alkoxy such as methoxy, or fluoro-C1-4-alkyl.
- In an alternative embodiment R3 is 4-pyridyl optionally substituted with one or more methyl groups.
- The compounds of the invention are useful in the treatment of cancers. Examples of such cancers include cancers of the haematopoietic system such as multiple myeloma and non-Hodgkin's lymphoma. Examples of other drugs which may be used in combination with the compounds of the invention for the treatment of cancers, including for example cancers of the haematopoietic system, include agents that inhibit growth factors such as GCSF and VEGF (e.g. avastin and aflibercept).
- The compounds of the invention are also useful in the treatment of injuries including damage to the heart, liver, kidney, brain, and bone. Examples of other drugs which may be used in combination with the compounds of the invention for the treatment of such injuries include agents that inhibit growth factors such as GCSF and VEGF.
- The compounds of the invention are useful in the treatment of viral infections, for example HIV/AIDS. Examples of other drugs which may be used in combination with the compounds of the invention for the treatment of viral infections include, for example, CCR5 antagonists including maraviroc and SCH532702, and antiretrovirals including reverse transcriptase inhibitors (e.g. zidovudine, abacavir, didanosine, zalcitabine, stavudine, lamivudine, emtricitabine, tenofovir, adefovir, nevirapine efavirenz, etravirine, delavirdineetc), and HIV protease inhibitors (e.g. saquinavir, ritonavir, indinavir, nelfinavir, amprenavir), and integrase inhibitors (e.g. raltegravir), and antivirals such as acyclovir and plecoranil.
- The compounds of the invention are useful in the treatment of neuropathy. An example of neuropathy is HIV related peripheral neuropathy, which affects approximately 50% of HIV patients. Examples of other drugs which may be used in combination with the compounds of the invention for the treatment of neuropathy, including HIV related peripheral neuropathy, include opiates such as fentanyl, anti-epileptics such as gabapentin and pregabalin, and tricyclics such as amitryptiline.
- The compounds of the invention are useful in the treatment of retinal neo-vascularisation, which is a major cause of blindness in patients with diabetes and age related macular degeneration. Examples of other drugs which may be used in combination with the compounds of the invention for the treatment of retinal neo-vascularisation include VEGF inhibitors such as avastin and lucentis.
- The compounds of the invention are useful in the treatment of several types of cancers, including non-small cell lung, breast and neuroblastoma. Examples of other drugs which may be used in combination with the compounds of the invention for the treatment of cancer include other anti-cancer drugs including anti-angiogenic agents such as avastin and inhibitors of VEGF and PDGF receptors such as lucentis and sutent.
- The compounds of formula (I) above may be prepared by, or in analogy with, conventional methods. The preparation of intermediates and compounds according to the examples of the present invention may in particular be illuminated by, but not limited to, the following Schemes. Definitions of variables in the structures in the schemes herein are commensurate with those of the corresponding positions in the formulae delineated herein.
- wherein R1, R2, R3, R4, X and Y are as defined in formula (I).
- Compounds of general formula (I) wherein X is a 2,6-pyridyl radical can easily be prepared from intermediate compounds of general formula (III) (as illustrated in
Scheme 1 above) by displacement of the halogen with H—Y—R2 or alternatively by displacement of the halogen with H—Y—H (or a suitably protected version thereof) and subsequent addition of the R2 group, for example by reductive alkylation with a carbonyl compound of formula O=R2. The group H—Y—R2 can be prepared for example by reductive alkylation of H—Y—H (or a suitably protected version thereof) with a carbonyl compound of formula O=R2. Intermediate compounds of general formula (III) can be readily prepared for example by Suzuki reaction of a boronic acid R′B(OH)2 with 2-chloro-6-iodopyridine, by condensation of an amine R3R4NH2 with 6-chloropyridine-2-carboxylic acid or by condensation of an a-halo ketone with 6-chloropyridine-2-carboximidamide. All of these alternatives are exemplified in the experimental section below. - wherein R1, R2, R3, R4, X and Y are as defined in formula (I).
- Compounds of general formula (I) wherein X is a 2,6-pyridyl radical can alternatively be readily prepared from intermediate compounds of general formula (IV) (as illustrated in Scheme 2 above) for example by condensation with an amine R3R4NH2, by conversion of the carboxylic acid group into a ketone group R3CO, or by conversion of the carboxylic group into a heteroaryl group by standard procedures. Intermediate compounds of general formula (IV) can be easily prepared from intermediate compounds of general formula (V) by deprotection of the tert-butyl ester. Intermediate compounds of general formula (V) can in turn be readily prepared from tert-butyl 6-chloropyridine-2-carboxylate by displacement of the halogen with H—Y—R2 or alternatively by displacement of the halogen with H—Y—H (or a suitably protected version thereof) and subsequent addition of the R2 group, for example by reductive alkylation with a carbonyl compound of formula O=R2. The group H—Y—R2 can be prepared for example by reductive alkylation of H—Y—H (or a suitably protected version thereof) with a carbonyl compound of formula O=R2. All of these alternatives are exemplified in the experimental section below.
- The groups R1 and R2 in
Schemes 1 and 2 can also be converted by standard synthetic methods into alternative groups R1 and R2. The routes described inSchemes 1 and 2 refer to X being a 2,6-pyridyl radical of formula (A). Analogous methods can be used to prepare compounds of formula (I) where X is alternatively a radical of formulae (B)-(G) inclusive. - Appropriate reaction conditions for the individual reaction steps are known to a person skilled in the art. Particular reaction conditions for examples of the invention are also described in the experimental section. The necessary starting materials for preparing the compounds of formula (I) are either commercially available, or may be prepared by methods known in the art.
- The processes described below in the experimental section may be carried out to give a compound of the invention in the form of a free base or as an acid addition salt. A pharmaceutically acceptable acid addition salt may be obtained by dissolving the free base in a suitable organic solvent and treating the solution with an acid, in accordance with conventional procedures for preparing acid addition salts from base compounds. Examples of addition salt forming acids are mentioned above.
- The compounds of formula (I) may possess one or more chiral carbon atoms, and they may therefore be obtained in the form of optical isomers, e.g., as a pure enantiomer, or as a mixture of enantiomers (racemate) or as a mixture containing diastereomers. The separation of mixtures of optical isomers to obtain pure enantiomers is well known in the art and may, for example, be achieved by fractional crystallization of salts with optically active (chiral) acids or by chromatographic separation on chiral columns.
- The chemicals used in the synthetic routes delineated herein may include, for example, solvents, reagents, catalysts, and protecting group and deprotecting group reagents. Examples of protecting groups are t-butoxycarbonyl (Boc) and benzyl. The methods described above may also additionally include steps, either before or after the steps described specifically herein, to add or remove suitable protecting groups in order to ultimately allow synthesis of the compounds. In addition, various synthetic steps may be performed in an alternate sequence or order to give the desired compounds. Synthetic chemistry transformations and protecting group methodologies (protection and deprotection) useful in synthesizing applicable compounds are known in the art and include, for example, those described in R. Larock, Comprehensive Organic Transformations, VCH Publishers (1989); T. W. Greene and P. G. M. Wuts, Protective Groups in Organic Synthesis, 3rd Ed., John Wiley and Sons (1999); L. Fieser and M. Fieser, Fieser and Fieser's Reagents for Organic Synthesis, John Wiley and Sons (1994); and L. Paquette, ed., Encyclopedia of Reagents for Organic Synthesis, John Wiley and Sons (1995) and subsequent editions thereof.
- The following abbreviations have been used:
-
aq aqueous BINAP 2,2′-Bis(diphenylphosphino)-1,1′-binaphthyl Boc tert-Butyloxycarbonyl DAST Diethylaminosulfur trifluoride DCE 1,2-Dichloroethane DCM Dichloromethane DIPEA N,N-Diisopropylethylamine DMA Dimethylacetamide DME 1,2-Dimethoxyethane DMF N,N-Dimethylformamide EDC•HC1 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride ES+ Electrospray ESI+ Electrospray ionization Et3N Triethylamine Et2O Diethyl ether EtOAc Ethyl acetate EtOH Ethanol HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate HOBt N-Hydroxybenzotriazole HONB endo-N-Hydroxybicyclo[2.2.1]hept-5-ene-2,3-dicarboximide HPLC High Performance Liquid Chromatography HPLC-MS High Performance Liquid Chromatography-Mass Spectrometry HRMS High Resolution Mass Spectrometry IBX 2-Iodoxybenzoic acid Int Intermediate IPA Isopropanol LCMS Liquid Chromatography Mass Spectrometry M Molar MeCN Acetonitrile MeOH Methanol [MH]+ Protonated molecular ion MSD-TOF Mass Selective Detector-Time of Flight NEM N-Ethylmorpholine NMP N-methylpyrrolidone PPh3 Triphenylphosphine Proc Procedure sat saturated SM Starting material TFA Trifluoroacetic acid THF Tetrahydrofuran TLC Thin Layer Chromatography - The recitation of a listing of chemical groups in any definition of a variable herein includes definitions of that variable as any single group or combination of listed groups. The recitation of an embodiment herein includes that embodiment as any single embodiment or in combination with any other embodiments or portions thereof.
- The invention will now be further illustrated by the following non-limiting examples. The specific examples below are to be construed as merely illustrative, and not limitative of the remainder of the disclosure in any way whatsoever. Without further elaboration, it is believed that one skilled in the art can, based on the description herein, utilize the present invention to its fullest extent. All references and publications cited herein are hereby incorporated by reference in their entirety.
- All reagents were commercial grade and were used as received without further purification, unless otherwise specified. Reagent grade solvents were used in all cases. High-resolution mass spectra (HRMS) were obtained on an Agilent MSD-TOF connected to an Agilent 1100 HPLC system. During the analyses the calibration was checked by two masses and automatically corrected when needed. Spectra were acquired in positive electrospray mode. The acquired mass range was m/z 100-1100. Profile detection of the mass peaks was used. Analytical HPLC was performed on an Agilent 1100 system using a Phenomenex Synergi, RP-Hydro, 150×4.6 mm, 4 μm column with a flow rate of 1.5 mL per min at 30° C. and a gradient of 5-100% acetonitrile (+0.085% TFA) in water (+0.1% TFA) over 7 min, (200-300 nm), unless otherwise stated. Flash chromatography was performed on either a CombiFlash Companion system equipped with RediSep or GraceResolv silica columns or a Flash Master Personal system equipped with Strata SI-1 silica gigatubes or in a glass column under gravity (ICN silica, 18-32 μm, 60 Å). Reverse Phase HPLC was performed on a Gilson system (Gilson 322 pump with Gilson 321 equilibration pump and Gilson 215 autosampler) equipped with Phenomenex
Synergi Hydro RP 150×10 mm, ACE-SAQ, 100×21.20 mm or YMC ODS-A 100/150×20 mm columns. Reverse phase column chromatography was performed on a Gilson system (Gilson 321 pump and Gilson FC204 fraction collector) equipped with Merck LiChroprep® RP-18 (40-63 um) silica columns. Microwave irradiations were carried out using a Biotage or CEM microwave. Hydrogenations were performed using a Thales H-cube or H-cube midi. The compounds were automatically named using ACD 6.0. All compounds were dried in a vacuum oven overnight. Yields have been rounded to the nearest %. Where yields are not included, the intermediates were used crude. Reactions were monitored by TLC, LCMS or HPLC. Reactions were performed at room temperature unless otherwise stated. -
- 2-Aminocyclopentanol hydrochloride (500 mg, 3.63 mmol) and benzaldehyde (810 mg, 7.63 mmol) were dissolved in DCM (20 mL), NaBH(OAc)3 (2.31 g, 10.9 mmol) was added and the reaction mixture was stirred for 24 h. The reaction mixture was diluted with DCM (50 mL), washed with sat aq Na2CO3, (40 mL), brine (30 mL) and dried (MgSO4). The reaction mixture was stirred with isocyanate resin for 18 h, filtered and concentrated in vacuo to give the crude title compound (436 mg, 43%) as a colourless oil. LCMS (ES+): 282.1 [MH]+.
-
- Intermediate 1 (400 mg, 1.42 mmol) was dissolved in DCM (20 mL) and DAST (344 mg, 2.13 mmol) was added. The reaction mixture was stirred for 4 h, diluted with DCM (30 mL), washed with sat aq NaHCO3 (40 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (330 mg, 82%) as a light brown gum. LCMS (ES+): 284.1 [MH]+.
-
- Intermediate 2 (330 mg, 116 mmol) was dissolved in MeOH (15 mL) and hydrogenated using an H-Cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C. The resulting MeOH solution was used without purification. LCMS (ES+): 104.0 [MH]+.
-
- Fluoroacetone (500 mg, 6.57 mmol), benzylamine (704 mg, 6.57 mmol) and NaBH(OAc)3 (4.18 g, 19.7 mmol) were dissolved in DCM (20 mL) and stirred for 18 h. The reaction mixture was diluted with DCM (80 mL), washed with sat aq Na2CO3 (75 mL), brine (75 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in MeOH (10 mL), 10% Pd/C (100 mg) was added and the reaction mixture was stirred for 4 d under an atmosphere of H2. The reaction mixture was filtered through celite and the resulting MeOH solution was used without purification. LCMS (ES+): 77.8 [MH]+.
-
- Intermediate 5 was prepared similarly to Intermediate 4 using 4,4,4-trifluoro-2-butanone instead of fluoroacetone. LCMS (ES+): 128.1 [MH]+.
-
- Intermediate 6 was prepared similarly to Intermediate 4 using 1,1-difluoroacetone instead of fluoroacetone. LCMS (ES+): 96.0 [MH]+.
-
- 1,4-Pentadien-3-ol (200 mg, 2.38 mmol) and IBX (999 mg, 3.57 mmol) were dissolved in DCE (15 mL) and heated at 70° C. for 3 h. The reaction mixture was filtered, diluted with MeOH (10 mL) and 2-fluoro-1-fluoromethyl-ethylamine (226 mg, 2.38 mmol) was added. The reaction mixture was stirred at 70° C. for 3 h. Isocyanate resin was added and the reaction mixture stirred at room temperature for 6 h, filtered and concentrated in vacuo to give the crude title compound (160 mg, 38%) as an orange gum. LCMS (ES+): 178.1 [MH]+.
- Intermediates 8-20 were prepared similarly to Intermediate 7; see Table 1 below.
-
TABLE 1 Preparation of piperidin-4-one intermediates LCMS Int Structure SM Yield (ES+) Intermediate Name 8 * 44% 156.2 [MH]+ 1-[(2R)-Butan-2-yl]piperidin-4-one 9 * 46% 156.2 [MH]+ 1-[(2S)-Butan-2-yl]piperidin-4- one 10 Int 4 37% 160.1 [MH]+ 1-(1-Fluoropropan-2-yl)piperidin- 4-one 11 Int 6 38% 178.1 [MH]+ 1-(1,1-Difluoropropan-2- yl)piperidin-4-one 12 * 33% 196.2 [MH]+ 1-[(2S)-1,1,1-Trifluoropropan-2- yl]piperidin-4-one 13 * 33% 196.2 [MH]+ 1-[(2R)-1,1,1-Trifluoropropan-2- yl]piperidin-4-one 14 * 29% 210.1 [MH]+ 1-(1,1,1-Trifluoro-2-methylpropan- 2-yl)piperidin-4-one 15 Int 5 29% 210.1 [MH]+ 1-(4,4,4-Trifluorobutan-2- yl)piperidin-4-one 16 Int 3 20% 186.1 [MH]+ 1-(2-Fluorocyclopentyl)piperidin-4- one 17 * 45% 204.1 [MH]+ 1-[(1R)-1-Phenylethyl]piperidin-4- one 18 * 39% 222.1 [MH]+ 1-[(1R)-1-(4- Fluorophenyl)ethyl]piperidin-4-one 19 * 43% — 1-[(1R)-2,3-Dihydro-1H-inden-1- yl]piperidin-4- one 20 * 45% 216 [MH]+ 1-[(1S)-2,3-Dihydro-1H-inden-1- yl]piperidin-4-one *Commercially available -
- 4-Piperidone hydrochloride monohydrate (1.00 g, 6.50 mmol), 2-bromoethyl methyl ether (1.00 g, 7.20 mmol) and K2CO3 (1.80 g, 13.0 mmol) were dissolved in MeCN (20 mL) and the reaction mixture was stirred at 75° C. for 6 h. The reaction mixture was filtered and the solvents removed in vacuo. The residue was dissolved in DCM (30 mL), stirred with isocyanate resin for 2 h, dried (MgSO4) and concentrated in vacuo to give the crude title compound (180 mg, 18%) as a colourless gum.
- Intermediates 22-25 were prepared similarly to Intermediate 21; see Table 2 below.
-
TABLE 2 Preparation of piperidin-4-one intermediates LCMS Int Structure Yield (ES+) Intermediate Name 22 20% 156.2 [MH]+ 1-(Butan-2-yl)piperidin-4-one 23 11% 170.2 [MH]+ 1-(Pentan-3-yl)piperidin-4-one 24 11% 168.2 [MH]+ 1-Cyclopentylpiperidin-4-one 25 91% 224.0 [MH]+ 1-[(2-Chlorophenyl) methyl]piperidin-4-one -
- 2-Pentanone (10.6 mL, 100 mmol) was dissolved in MeOH (60 mL) and cooled to −5° C. Bromine (5.13 mL, 100 mmol) was added and the reaction mixture was stirred for 4 h keeping the temperature below 10° C. Water (30 mL) was added and the reaction mixture was stirred overnight at room temperature. The reaction mixture was poured into water (100 mL) and extracted with DCM (2×200 mL). The combined organic fractions were washed with sat aq NaHCO3 (200 mL), water (200 mL), dried (CaCl2) and concentrated in vacuo. The residue was purified by Kugelrohr distillation to give the title compound as a pale yellow oil (8.22 g, 50%).
- Intermediates 27-32 were prepared similarly to Intermediate 26; see Table 3 below.
-
- 2-Hexanone (4.94 mL, 39.9 mmol) and iodine (20.2 g, 79.9 mmol) were dissolved in DME (100 mL) and stirred for 24 h. The reaction mixture was diluted with EtOAc (200 mL) and washed with 1M aq potassium thiosulfate (200 mL), 1M aq Na2CO3 (200 mL) and water (100 mL). The organic fraction was dried (MgSO4) and concentrated in vacuo. The residue was purified by Kugelrohr distillation (120° C., 1 mBar) to give the title compound as a dark brown oil (2.46 g, 27%).
-
- 2-tert-Butoxycarbonylamino-butyric acid (500 mg, 2.46 mmol), HBTU (1.03 g, 2.71 mmol) and DIPEA (1.22 mL, 7.38 mmol) were dissolved in DMF (10 mL) and stirred for 30 min. N,O-dimethylhydroxylamine hydrochloride (360 mg, 3.69 mmol) was added and the reaction mixture was stirred for 1 h. The solvents were removed in vacuo and the residue was purified by column chromatography to give the title compound (380 mg, 63%) as a cream oil. LCMS (ES+): 269.2 [MNa]+.
-
- Intermediate 34 (4.97 g, 20.2 mmol) was dissolved in THF (100 mL) and ethylmagnesium bromide (20.0 mL, 3.2 M in 2-methyltetrahydrofuran, 64.0 mmol) was added. The reaction mixture was stirred for 4 h, quenched with sat aq NH4Cl (20 mL) and extracted with EtOAc (2×200 mL). The combined organic fractions were washed with 1 M aq HCl (200 mL), 1 M aq Na2CO3 (200 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (100 mL), TFA (25 mL) was added and the reaction mixture was stirred for 3 h and concentrated in vacuo to give the crude title compound (4.98 g) as a red gum. LCMS (ES+): 116.2 [MH]+.
-
- 6-Chloropyridine-2-carboxylic acid (5.00 g, 31.7 mmol) was dissolved in DCM (150 mL) and oxalyl chloride (5.45 mL, 63.5 mmol) and DMF (1 mL) were added. The reaction mixture was stirred for 3 h, concentrated in vacuo and azeotroped with DCM. The residue was dissolved in THF (150 mL) and potassium tert-butoxide (3.39 mg, 47.6 mmol) was added. The reaction mixture was stirred for 18 h, quenched with water (250 mL) and extracted with DCM (3×150 mL). The combined organic fractions were washed with sat aq NaHCO3 (150 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (3.11 g, 46%) as a white solid. LCMS (ES+): 236.1 [MNa]+.
-
- 6-Chloropyridine-2-carboxylic acid (15.0 g, 0.11 mol) was dissolved in DCM (300 mL) and DMF (1.5 mL) and oxalyl chloride (27.4 g, 0.22 mol) was added dropwise over 10 min. The reaction mixture was stirred for 1 h, MeOH (50 mL) was added dropwise over 5 min and the reaction mixture was stirred for 1.5 h. The solvents were removed in vacuo and the residue azeotroped with DCM (2×150 mL) to give the crude title compound (16.5 g, 100%) as a green solid. LCMS (ES+): 154.5 [MH]+.
-
- 6-Chloropyridine-2-carboxylic acid (5.00 g, 31.7 mmol) was dissolved in DCM (100 mL) and DMF (0.5 mL) and oxalyl chloride (6.54 mL, 76.2 mmol) were added dropwise. The reaction mixture was stirred for 2 h, concentrated in vacuo and azeotroped with DCM. The residue was dissolved in DCM (100 mL), DIPEA (22.6 mL, 127 mmol) and aminomethylcyclopropane (5.51 mL, 63.5 mmol) were added dropwise and the reaction mixture was stirred for 4 h. The reaction mixture was washed with sat aq NaHCO3 solution (250 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (6.50 g, 97%) as a light brown gum. LCMS (ES+): 211.2 [MH]+.
- Intermediates 39-44 were prepared similarly to Intermediate 38; see Table 4 below.
-
TABLE 4 Preparation of 6-chloro-pyridine-2-carboxamide intermediates Int Crude yield LCMS (ES+) Intermediate Name 39 37% 234.2 [MH]+ 6-Chloro-N- (pyridin-4- yl)pyridine- 2- carboxamide 40 100% 248.0 [MH]+ 6-Chloro-N- (2-methylpyridin-4- yl)pyridine-2- carboxamide 41 96% 248.2 [MH]+ 6-Chloro-N- (3-methylpyridin-4- yl)pyridine-2- carboxamide 42 46% 262.1 [MH]+ 6-Chloro-N-(2,6- dimethylpyridin-4- yl)pyridine-2- carboxamide 43 94% 248.3 [MH]+ 6-Chloro-N- (pyridin-3- ylmethyl)pyridine- 2-carboxamide 44 71% 254.2 [MH]+ 6-Chloro-N-(1,3- thiazol-2- ylmethyl)pyridine- 2-carboxamide -
- 6-Chloropyridine-2-carboxylic acid (1.20 g, 7.62 mmol) and ammonium chloride (0.81 g, 15.2 mmol) were dissolved in DMF (20 mL) and DIPEA (5.31 mL, 30.5 mmol), HONB (2.05 g, 11.4 mmol) and HBTU (4.33 g, 11.4 mmol) were added. The reaction mixture was stirred for 1 h and the solvents were removed in vacuo. The residue was partitioned between DCM (50 mL) and 1 M aq HCl (50 mL) and the aq fraction was extracted with DCM (2×25 mL). The combined organic fractions were washed with sat aq NaHCO3 (50 mL), brine (50 mL), dried (MgSO4) and concentrated in vacuo. The residue was recrystallised from MeOH/water to give the title compound (1.12 g, 94%) as a white solid. LCMS (ES+): 157.4 [MH]+.
-
- Intermediate 46 was prepared similarly to Intermediate 45, using Intermediate 35 instead of ammonium chloride, to give the crude title compound (33%) as an orange oil. LCMS (ES+): 255.1 [MH]+.
-
- 6-Chloro-pyridine-2-carboxylic acid (500 mg, 3.17 mmol), EDC.HCl (1.34 g, 6.98 mmol) and HOBN (1.42 g, 7.93 mmol) were dissolved in DCM (30 mL) and NEM (914 mg, 7.93 mmol) and n-butylamine (376 μL, 3.81 mmol) were added. The reaction mixture was stirred for 16 h, washed with sat aq NaHCO3 (2×20 mL), 1 M aq HCl (2×20 mL), brine (20 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (321 mg, 48%) as a colourless liquid. LCMS (ES+): 213.5 [MH]+.
-
- Intermediate 48 was prepared similarly to Intermediate 47, using ethylamine instead of n-butylamine to give the crude title compound (45%) as a colourless liquid. LCMS (ES+): 185.5 [MH]+.
-
- 6-Chloro-pyridine-2-carboxylic acid (1.00 g, 6.35 mmol) was dissolved in DCM (20 mL) and HOBt (1.03 g, 7.62 mmol), EDC.HCl (1.46 g, 7.62 mmol) and 1-(3-aminopropyl)imidazole (0.95 g, 7.62 mmol) were added. The reaction mixture was stirred for 18 h, diluted with DCM (130 mL) washed with sat aq Na2CO3 (100 mL), brine (30 mL), water (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was triturated with water to give the crude title compound (1.05 g, 63%) as an off-white solid. LCMS (ES+): 266 [MH]+.
-
- 2-Chloro-6-iodopyridine (400 mg, 1.67 mmol), N-methylindole-2-boronic acid (292 mg, 1.67 mmol), tetrakis(triphenylphosphine)palladium (0) (154 mg, 0.13 mmol) and Na2CO3 (442 mg, 4.18 mmol) were dissolved in water (10 mL) and dioxane (10 mL) and heated using a microwave (110° C., absorption high) for 1 h. The solvents were removed in vacuo and the residue was partitioned between DCM (50 mL) and water (30 mL). The aq fraction was extracted with DCM (30 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the crude title compound (406 mg) as a brown gum. LCMS (ES+): 243.2 [MH]+.
- Intermediates 51-60 were prepared similarly to
Intermediate 50; see Table 5 below. -
TABLE 5 Suzuki reactions with 2-Chloro-6-iodopyridine Crude LCMS Int R1 yield (ES +) Intermediate Name 51 62% 330.3 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)- 1H-pyrrolo[3,2-b]pyridine-1- carboxylate 52 100% 330.3 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)- 1H-pyrrolo[3,2-c]pyridine-1- carboxylate 53 60% 330.3 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)- 1H-pyrrolo[2,3-c]pyridine-1- carboxylate 54 90% 330.3 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)- 1H-pyrrolo[2,3-b]pyridine-1- carboxylate 55 67% 329.0 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)- 1H-indole-1-carboxylate 56 39%* 370.2 [MH]+ 2[1-(Benzenesulfonyl)-1H- pyrrolo[2,3-b]pyridin-3-yl]-6- chloropyridine 57 78% 329.0 [MH]+ tert-Butyl3-(6-chloropyridin-2-yl)- 1H-indole-1-carboxylate 58 100% 355.2 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)-6- cyano-1H-indole-1-carboxylate 59 100% 359.1 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)-6- methoxy-1H-indole-1- carboxylate 60 100% 359.4 [MH]+ tert-Butyl2-(6-chloropyridin-2-yl)-5- methoxy-1H-indole-1-carboxylate *Used the corresponding pinacol boronic ester derivative instead of the boronic acid -
- 2-Chloro-6-cyanopyridine (11.2 g, 80.8 mmol) was dissolved in EtOH (200 mL), HCl gas was passed through the solution for 5 min and the reaction mixture was stirred for 18 h. The solvent was removed in vacuo and the residue was dissolved in a 7 M solution of ammonia in MeOH (100 mL) and stirred for 3 d. The solvent was removed in vacuo and the residue triturated with EtOAc (3×50 mL) to give the crude title compound as a pale pink solid (12.3 g, 98%). LCMS (ES+): 156.2 [MH]+.
-
- Intermediate 61 (500 mg, 3.21 mmol), bromoacetone (296 μL, 3.53 mmol) and K2CO3 (444 mg, 3.21 mmol) were dissolved in EtOH (10 mL) and heated at reflux for 2 h. Further bromoacetone (148 μL, 1.77 mmol) was added and the reaction mixture was heated at reflux for 4 h. The solvents were removed in vacuo and the residue was dissolved in 1 M aq Na2CO3 (50 mL) and extracted with EtOAc (3×50 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (420 mg, 68%) as an orange gum. LCMS (ES+): 194.1 [MH]+.
- Intermediates 63-74 were prepared similarly to Intermediate 62 using the appropriate alpha-bromoketone intermediate; see Table 6 below.
-
TABLE 6 Preparation of imidazoles from Intermediate 61 Crude LCMS Int R1 SM yield (ES) Intermediate Name 63 * 32% — 2-Chloro-6-(5-ethyl-1H-imidazol-2- yl)pyridine 64 Int 26 77% 222.2 [MH]+ 2-Chloro-6-(5-propyl-1H-imidazol- 2-yl)pyridine 65 Int 27 73% 222.1 [MH]+ 2-Chloro-6-[5-(propan-2-yl)-1H- imidazol-2-yl]pyridine 66 Int 28 88% 220.2 [MH]+ 2-Chloro-6-(5-cyclopropyl-1H- imidazol-2-yl)pyridine 67 * 27% 248.1 [MH]+ 2-Chloro-6-(5-(trifluoromethyl)-1H- imidazol-2-yl]pyridine 68 * 54% 236.2 [MH]+ 2-(5-Tert-butyl-1H-imidazol-2-yl)- 6-chloropyridine 69 * 25% 256.2 [MH]+ 2-Chloro-6-(5-phenyl-1H-imidazol- 2-yl)pyridine 70 Int 29 50% 208.1 [MH]+ 2-Chloro-6-(4,5-dimethyl-1H- imidazol-2-yl)pyridine 71 Int 3042% 222.2 [MH]+ 2-Chloro-6-(5-ethyl-4-methyl-1H- imidazol-2-yl)pyridine 72 Int 31 13% 234.1 [MH]+ 2-Chloro-6-(5-cyclopropyl-4- methyl-1H-imidazol-2-yl)pyridine 73 Int 32 15% 248.1 [MH]+ 2-Chloro-6-(5-cyclopropyl-4-ethyl- 1H-imidazol-2-yl)pyridine 74 Int 33 45% 236.1 [MH]+ 2-Chloro-6-(4-methyl-5-propyl-1H- imidazol-2-yl)pyridine * Commercially available -
- Intermediate 46 (1.81 g, 7.11 mmol) and ammonium acetate (274 mg, 3.55 mmol) were dissolved in 7 M ammonia in methanol (15 mL) and heated using a microwave at 100° C. for 30 min and at 120° C. for 30 min. Further ammonium acetate (1.00 g, 13.0 mmol) was added and the reaction mixture was heated using a microwave at 120° C. for 2 h, poured into water (100 mL) and extracted with DCM (3×100 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (1.54 g, 92%) as a yellow oil. LCMS (ES+): 236.1 [MH]+.
-
- Intermediate 63 (203 mg, 0.98 mmol) and NaH (47.0 mg, 60% dispersion in mineral oil, 1.17 mmol) were dissolved in THF (10 mL), iodomethane (67.0 μL, 1.08 mmol) was added and the reaction mixture was stirred for 2 h, poured into water (25 mL) and extracted with EtOAc (3×25 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the crude title compound as a pale yellow oil (212 mg, 98%). LCMS (ES+): 222.2 [MH]+.
-
- 6-Chloropyridine-2-carboxylic acid (2.00 g, 12.7 mmol), 3,4-diaminopyridine (1.52 g, 14.0 mmol) and DIPEA (2.43 mL, 14.0 mmol) were dissolved in DMF (20 mL) and HBTU (5.29 g, 14.0 mmol) was added. The reaction mixture was stirred for 48 h and concentrated in vacuo. The residue was dissolved in EtOAc (100 mL), washed with 1 M aq Na2CO3 (2×100 mL), water (100 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography, dissolved in AcOH and heated at 120° C. for 50 min. The solvent was removed in vacuo and the residue was suspended in 1 M aq Na2CO3 (50 mL) and extracted with EtOAc (5×50 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and recrystallisation from MeOH to give the title compound (534 mg, 37%) as a white solid.
-
- Intermediate 36 (3.00 g, 14.0 mmol) was dissolved in DMA (60 mL) and homopiperazine (7.03 g, 70.2 mmol) was added. The reaction mixture was heated using a microwave (180° C., absorption high) for 35 min and the solvents were removed in vacuo. The residue was dissolved in DCM (150 mL) and washed with sat aq Na2CO3 (100 mL), brine (100 mL), dried (MgSO4) and the solvents were removed in vacuo to give the crude title compound (3.37 g, 87%) as a yellow liquid. LCMS (ES+): 278.1 [MH]+.
- Intermediates 79-118 were prepared similarly to Intermediate 78, by reacting 6-chloro-2-substituted pyridines with homopiperazine; see Table 7 below.
-
TABLE 7 Preparation of 6-(1,4-diazepany-1-yl)-2-substituted pyridine intermediates Crude LCMS Int R1 SM yield (ES) Intermediate Name 79 Int 45 — 221.2 [MH]+ 6-(1,4-Diazepan-1-yl)pyridine-2- carboxamide 80 Int 48 66% 249.6 [MH]+ 6-(1,4-Diazepan-1-yl)-N- ethylpyridine-2-carboxamide 81 Int 38 87% 275.4 [MH]+ N-(Cyclopropylmethyl)-6-(1,4- diazepan-1-yl)pyridine-2- carboxamide 82 Int 47 63% 277.7 [MH]+ N-Butyl-6-(1,4-diazepan-1- yl)pyridine-2-carboxamide 83 Int 39 90% 298.2 [MH]+ 6-(1,4-Diazepan-1-yl)-N-(pyridin-4- yl)pyridine-2-carboxamide 84 Int 4078% 312.2 [MH]+ 6-(1,4-Diazepan-1-yl)-N-(2- methylpyridin-4-yl)pyridine-2- carboxamide 85 Int 41 — 312.2 [MH]+ 6-(1,4-Diazepan-1-yl)-N-(3- methylpyridin-4-yl)pyridine-2- carboxamide 86 Int 42 70% 326.3 [MH]+ 6-(1,4-Diazepan-1-yl)-N-(2,6- dimethylpyridin-4-yl)pyridine-2- carboxamide 87 Int 43 80% 312.4 [MH]+ 6-(1,4-Diazepan-1-yl)-N-(pyridin-3- ylmethyl)pyridine-2-carboxamide 88 Int 44 — 318.3 [MH]+ 6-(1,4-Diazepan-1-yl)-N-(1,3- thiazol-2-ylmethyl)pyridine-2- carboxamide 89 Int 49 76% — 6-(1,4-Diazepan-1-yl)-N[3-(1H- imidazol-1-yl)propyl]pyridine-2- carboxamide 90 Int 50— 307.2 [MH]+ 2-[6-(1,4-Diazepan-1-yl)pyridin-2- yl]-1-methyl-1H-indole 91 Int 51* — 294.4 [MH]+ 1-(6-{1H-Pyrrolo[3,2-b]pyridin-2- yl}pyridin-2-yl)-1,4-diazepane 92 Int 52* 90% 294.4 [MH]+ 1-(6-{1H-Pyrrolo[3,2-c]pyridin-2- yl]pyridin-2-yl)-1,4-diazepane 93 Int 53* — 294.4 [MH]+ 1-(6-{1H-Pyrrolo[2,3-c]pyridin-2- yl}pyridin-2-yl)-1,4-diazepane 94 Int 54* — 294.4 [MH]+ 1-(6-{1H-Pyrrolo[2,3-b]pyridin-2- yl}pyridin-2-yl)-1,4-diazepane 95 H293.1 Int 55* — [Mf1]+ 2-[6-(1,4-Diazepan-1-yl)pyridin-2- y11-1H-indole 96 Int 56* — 294.4 [MH]+ 1-(6-{1H-Pyrrolo[2,3-b]pyridin-3- yl}pyridin-2-yl)-1,4-diazepane 97 Int 57* 90% 293.1 [MH]+ 3-[6-(1,4-Diazepan-1-yl)pyridin-2- yl]-1H-indole 98 Int 58* — 318.2 [MH]+ 2-[6-(1,4-Diazepan-1-yl)pyridin-2- yl[-1H-indole-6-carbonitrile 99 Int 59* — 323.2 [MH]+ 2-[6-(1,4-Diazepan-1-yl)pyridin-2- yl]-6-methoxy-1H- indole 100 Int 60*— 323.4 [MH]+ 2[6-(1,4-Diazepan-1-Y1)pyridin-2- yl]-5-methoxy-1H-indole 101 Int 62 — 258.3 [MH]+ 1-[6-(5-Methyl-1H-imidazol-2- yl)pyridin-2-yl]-1,4-diazepane 102 Int 77 74% 295.2 [MH]+ 1-[6-{1H-Imidazo[4,5-c]pyridin-2- yl}pyridin-2-yl)-1,4-diazepane 103 Int 63 26% 272 [MH]+ 1-[6-(5-Ethyl-1H-imidazol-2- yl)pyridin-2-yl]-1,4-diazepane 104 Int 64 — 286.3 [MH]+ 1-[6-(5-Propyl-1H-imidazol-2- yl)pyridin-2-yl]-1,4-diazepane 105 Int 65 286.3 [MH]+ 1-{6[5-(Propan-2-yl)-1H-imidazol- 2-yl)pyridin-2-yl}-1,4-diazepane 106 Int 66 — 284.2 [MH]+ 1-[6-(5-Cyclopropyl-1H-imidazol- 2-yl)pyridin-2-yl]-1,4-diazepane 107 Int 67 61% 312.3 [MH]+ 1-16-[5-(Trifluoromethyl)-1H- imidazol-2-yl]pyridin-2-yl}-1,4- diazepane 108 Int 68 300.3 [MH]+ 1[6-(5-tert-Butyl-1H-imidazol-2- yl)pyridin-2-yl]-1,4-diazepane 109 Int 69 — 320.3 [MH]+ 1-[6-(5-Phenyl-1H-imidazol-2- yl)pyridin-2-yl]-1,4-diazepane 110 Int 70 — 272.2 [MH]+ 1-[6-(4,5-Dimethyl-1H-imidazol-2- yl)pyridin-2-yl]-1,4-diazepane 111 Int 71 286.3 [MH]+ 1-[6-(5-Ethyl-4-methyl-1H- imidazol-2-yl]pyridin-2-yl]-1,4- diazepane 112 Int 75 300.3 [MH]+ 1-[6-(4,5-Diethyl-1H-imidazol-2- yl)pyridin-2-yl]-1,4-diazepane 113 Int 72 83% 298.2 [MH]+ 1-[6-(5-Cyclopropyl-4-methyl-1H- imidazol-2-yl)pyridin-2-yl]-1,4- diazepane 114 Int 73 73% 312.3 [MH]+ 1-[6-(5-Cyclopropyl-4-ethyl-1H- imidazol-2-yl)pyridin-2-yl]-1,4- diazepane 115 Int 74 — 300.2 [MH]+ 1-[6-(4-Methyl-5-propyl-1H- imidazol-2-yl)pyridin-2-yl]-1,4- diazepane 116 # 58% 203.1 [MH]+ 6-(1,4-Diazepan-1-yl)pyridine-2- carbonitrile 117 Int 76 — 286.2 [MH]+ 1-[6-(4-Ethyl-1-methyl-1H- imidazol-2-yl)pyridin-2-yl]-1,4- diazepane 118 Int 37 46% 236.6 [MH]+ Methyl6-(1,4-diazepan-1- yl)pyridine-2-carboxylate *The Boc/benzenesulfonyl protecting group is removed during the course of this reaction # Commercially available -
- Intermediate 81 (1.50 g, 5.50 mmol) and 4-oxo-piperidine-1-carboxylic acid tert butylester (1.09 g, 5.50 mmol) were dissolved in DCM (30 mL) and NaBH(OAc)3 (5.79 g, 27.3 mmol) was added. The reaction mixture was stirred for 4 d, diluted with DCM (150 mL), washed with sat aq Na2CO3 (2×75 mL), brine (75 mL) and dried (MgSO4). The reaction mixture was stirred with isocyanate resin for 2 h and the solvents were removed in vacuo. The residue was dissolved in DCM (40 mL), TFA (4 mL) was added and the reaction mixture was stirred for 18 h. The solvents were removed in vacuo and the residue was desalted (K2CO3 in DCM) and purified by column chromatography to give the title compound (600 mg, 31%) as a colourless gum. LCMS (ES+): 357.8 [MH]+.
- Intermediates 120-124 were prepared similarly to Intermediate 119, by reacting 6-(1,4-diazepany-1-yl)-2-substituted pyridines with 4-oxo-piperidine-1-carboxylic acid tert butylester and removing the Boc protecting group; see Table 8 below.
-
TABLE 8 Preparation of 6-[4-(piperidin-4-yl)-1,4-diazepan-1-yl]-2-substituted pyridine intermediates LCMS Int R1 SM Yield (ES +) Intermediate Name 120 Int 79 33% 304.2 [MH]+ 6-[4-(Piperidin-4-yl)-1,4-diazepan- 1-yl[pyridine-2-carboxamide 121 Int 80— — N-Ethyl-6-[4-(piperidin-4-yl)-1,4- diazepan-1-yl]pyridine-2- carboxamide 122 Int 82 — — N-Butyl-6-[4-(piperidin-4-yl)-1,4- diazepan-1-yl]pyridine-2- carboxamide 123 Int 89 38% — N-[3-(1H-Imidazol-1-yl)propyl]-6- [4-(piperidin-4-yl)-1,4-diazepan-1- yl]pyridine-2-carboxamide 124 Int 118 33% 319.7 [MH]+ Methyl 6-[4-(piperidin-4-yl)-1,4- diazepan-1-yl]pyridine-2-carboxylate -
- Intermediate 125 was prepared similarly to Intermediate 119, using Intermediate 83 instead of Intermediate 81 and tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate instead of 4-oxo-piperidine-1-carboxylic acid tert butylester, to give the title compound (9%) as a colourless gum. LCMS (ES+): 399.4 [MH]+.
-
- Intermediate 126 was prepared similarly to Intermediate 119, using Intermediate 106 instead of Intermediate 81 and tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate instead of 4-oxo-piperidine-1-carboxylic acid tert butylester, to give the title compound (1%) as a pale yellow solid.
-
- Intermediate 127 was prepared similarly to Intermediate 119, using Intermediate 87 instead of Intermediate 81 and tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate instead of 4-oxo-piperidine-1-carboxylic acid tert butylester, to give the title compound (49%) as a colourless gum.
-
- Intermediate 87 (2.00 g, 7.29 mmol) was dissolved in EtOH (30 mL) and tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (4.36 g, 21.9 mmol) and Et3N (2.03 mL, 14.6 mmol) were added. The reaction mixture was heated at reflux for 20 h, diluted with DCM (200 mL), washed with sat aq Na2CO3 (100 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC. The residue was dissolved in DCM (2 mL), TFA (0.5 mL) was added and the reaction mixture was stirred for 5 h. The solvents were removed in vacuo and the residue was dissolved in DCM (50 mL), washed with sat aq Na2CO3 (25 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound.
-
- Intermediate 78 (3.37 g, 12.2 mmol) was dissolved in DCM (125 mL) and 1-(propan-2-yl)piperidin-4-one (3.61 mL, 24.3 mmol) and NaBH(OAc)3 (12.9 g, 60.8 mmol) were added. The reaction mixture was stirred for 18 h, diluted with DCM (250 mL) and quenched with sat aq Na2CO3 (150 mL). The aq fraction was extracted with DCM (2×100 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (3.29 g, 67%) as a yellow liquid. LCMS (ES+): 403.5 [MH]+.
- Intermediates 130-133 were prepared similarly to Intermediate 129, by reductive alkylation of 6-(1,4-diazepany-1-yl)-2-substituted pyridines; see Table 9 below.
-
TABLE 9 Reductive alkylation of 6-(1,4-diazepany-1-yl)-2-substituted pyridines SMs/ LCMS Int R1 R6 Yield (ES +) Intermediate Name 130 Int 25 Int 78 67% 403.5 [MH]+ tert-Butyl6-(4-{1-[(2- chlorophenyl)methyl]piperidin-4-yl}- 1,4-diazepan-1-yl)pyridine-2- carboxylate 131 Int 116 45% 328.2 [MH]+ 6-{4-[1-(Propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carbonitrile 132 Int 8 Int 116 1% 342.2 [MH]+ 6-(4-{1-[(2R)-Butan-2-yl]piperidin-4- yl}-1,4-diazepan-1-yl)pyridine-2- carbonitrile 133 Int 25 Int 124 26% 443.7 [MH]+ Methyl6-(4-{1-[(2- chlorophenyl)methyl]piperidin-4-yl}- 1,4-diazepan-1-yl)pyridine-2- carboxylate -
- Intermediate 78 (1.00 g, 3.61 mmol) and 4-tert-butylcyclohexanone (560 mg, 3.61 mmol) were dissolved in DCM (50 mL) and NaBH(OAc)3 (3.06 g, 14.4 mmol) was added. The reaction mixture was stirred for 3 d, diluted with DCM (150 mL), washed with sat aq Na2CO3 (100 mL), brine (75 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (75 mL) and TFA (6 mL) and stirred for 8 d. The solvents were removed in vacuo and the residue was purified by reverse phase column chromatography to give the title compound (536 mg, 41%) as a white solid. LCMS (ES+): 360.5 [MH]+.
-
- Intermediate 129 (3.29 g, 8.17 mmol) was dissolved in DCM (80 mL), TFA (40 mL) was added and the reaction mixture was stirred for 18 h. The solvents were removed in vacuo and the residue was neutralised with 1M aq Na2CO3. The aq solution was washed with DCM, concentrated in vacuo and purified by reverse phase column chromatography to give the title compound (2.19 g, 77%) as a white solid. LCMS (ES+): 347.5 [MH]+.
-
- Intermediate 136 was prepared similarly to Intermediate 135, using Intermediate 130 instead of Intermediate 129 to give the title compound (77%) as a white solid. LCMS (ES+): 347.5 [MH]+.
-
- Intermediate 131 (830 mg, 2.53 mmol) was dissolved in EtOH (20 mL) and hydroxylamine hydrochloride (880 mg, 12.7 mmol) and NaHCO3 (1.06 g, 12.7 mmol) were added. The reaction mixture was heated under reflux at 80° C. for 2 h. The reaction mixture was concentrated and the precipitate removed by filtration. The mother liquor was concentrated in vacuo to give the crude title compound (910 mg, 99%) as a light yellow gum. LCMS (ES+): 361.1 [MH]+.
-
- Intermediate 138 was prepared similarly to Intermediate 137, using Intermediate 132 instead of Intermediate 131, to give the crude title compound (65%) as a yellow gum. LCMS (ES+): 375.3 [MH]+.
-
- Intermediate 131 (982 mg, 3.00 mmol), NaN3 (215 mg, 3.30 mmol) and NH4Cl (250 mg, 4.50 mmol) were dissolved in DMF (5 mL) and heated at 120° C. for 4 h. Further NH4Cl (125 mg, 2.25 mmol) was added and the reaction mixture was heated at 120° C. for 5.5 h. The solvent was removed in vacuo, NaN3 (100 mg, 1.53 mmol) was added and the reaction mixture was heated at 120° C. for 7 h. The residue was purified by column chromatography to give the title compound (168 mg, 15%) as a dark red solid.
-
- 2-1 [(tert-Butoxy)carbonyl]amino acetic acid (5.00 g, 28.5 mmol) was dissolved in DCM (50 mL), CDI (5.09 g, 31.4 mmol) was added and the reaction mixture was stirred for 1 h. N,O-dimethylhydroxylamine hydrochloride (3.06 g, 31.4 mmol) was added and the reaction mixture was stirred for 16 h. EtOAc (150 mL) was added and the reaction mixture was washed with 1 M aq HCl (50 mL), sat aq NaHCO3 (2×50 mL), dried (Na2SO4) and concentrated in vacuo to give the crude title compound (5.13 g, 82%) as a white solid.
-
- Intermediate 140 (1.09 g, 5.00 mmol) was dissolved in THF (10 mL) at −10° C., n-butylmagnesium chloride (7.50 mL, 2.0 M in THF, 15.0 mmol) was added and the reaction mixture was warmed to room temperature overnight. Sat aq NH4Cl (60 mL) was added and the reaction mixture was extracted with EtOAc (3×20 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (1.00 g, 93%) as a colourless oil.
-
- Intermediate 141 (995 mg, 4.62 mmol) was dissolved in HCl (10 mL, 4.0 M in dioxane) and the reaction mixture was stirred for 4 h. The solvents were removed in vacuo to give the crude title compound (653 mg, 94%) as an off-white solid.
-
- Intermediate 142 (252 mg, 1.66 mmol), Intermediate 135 (1.33 g, 1.66 mmol) and HBTU (760 mg, 1.99 mmol) were dissolved in DCM (7.5 mL) and DMF (2.5 mL), DIPEA (1.72 g, 13.3 mmol) was added and the reaction mixture was stirred overnight. DCM (10 mL) was added and the reaction mixture was washed with water (3×5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (457 mg, 62%) as an off-white solid.
-
- Intermediate 129 (105 mg, 0.26 mmol) was dissolved in HCl (2 mL, 4.0 M in dioxane) and DCM (2 mL) and the reaction mixture was stirred overnight. MeOH (4 mL) was added, the reaction mixture was heated at 110° C. for 7.5 h and the solvents were removed in vacuo. The residue was partitioned between EtOAc and sat aq NaHCO3, and the organic fraction was dried (MgSO4) and concentrated in vacuo to give the crude title compound (59.0 mg, 63%) as an orange oil.
-
- Intermediate 144 (300 mg, 0.83 mmol) and hydrazine hydrate (280 mg, 5.60 mmol) were dissolved in MeOH (5 ml) and stirred overnight. The solvents were removed in vacuo, the residue was dissolved in MeOH and the solvents were removed in vacuo to give the crude title compound (265 mg, 89%) as a pale yellow glass.
-
- Intermediate 145 (60.0 mg, 0.16 mmol) and Et3N (81.0 mg, 0.80 mmol) were dissolved in DCM, cooled to 0° C. and a solution of cyclopropanecarbonyl chloride (16.7 mg, 0.16 mmol) in DCM was added. The reaction mixture was warmed to room temperature overnight. DCM was added and the reaction mixture was washed twice with sat aq Na2CO3, dried (MgSO4) and concentrated in vacuo to give the crude title compound (58.0 mg, 85%) as an off-white solid. LCMS (ES+): 429 [MH]+.
-
- Intermediate 131 (320 mg, 0.98 mmol) was dissolved in THF (10 mL) and cooled to 0° C. Ethylmagnesium chloride (1.50 mL, 2.0 M in THF, 3.00 mmol) was added dropwise and the reaction mixture was heated at reflux for 4 h. The reaction mixture was quenched with sat aq NH4Cl (20 mL) and sat aq Na2CO3 (20 mL) and extracted with EtOAc (20 mL×2). The combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the crude title compound (300 mg, 85%) as an orange gum.
-
- Intermediate 147 (300 mg, 0.84 mmol) was dissolved in DMF/DMA (3 mL) and heated at reflux overnight. The solvents were removed in vacuo and the residue was purified by reverse phase HPLC to give the title compound (45.0 mg, 20%) as an orange gum. LCMS (ES+): 414.4 [MH]+.
-
- 5-Methyl11,41diazepane (600 mg, 5.25 mmol) was dissolved in DMF (7.5 mL) and cooled to 0° C. A solution of di-tert-butyl-dicarbonate (1.03 g, 4.70 mmol) and triethylamine (3.60 mL, 26.0 mmol) in DCM (1 mL) was added dropwise over 3 h. The solvents were removed in vacuo and the residue dissolved in DCM (20 mL) and washed with sat aq Na2CO3 (5 mL). The aq fraction was extracted with DCM (3×50 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography, dissolved in DCM (20 mL) and washed with 2 M aq NaOH (10 mL). The aq fraction was extracted with DCM (3×50 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the title compound (194 mg, 17%) as a yellow oil. LCMS (ES+): 215.3 [MH]+.
-
- Intermediate 38 (60.5 mg, 0.29 mmol), Intermediate 149 (123 mg, 0.57 mmol) and DIPEA (200 μL, 1.15 mmol) was dissolved in NMP (750 μL) and heated using a microwave (185° C., absorption high) for 80 min. The solvents were removed in vacuo and the residue was dissolved in DCM (10 mL) and washed with sat aq Na2CO3 (1 mL). The aq fraction was extracted with DCM (3×20 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the crude title compound (50.0 mg) as a brown oil. LCMS (ES+): 289.4 [MH]+.
-
- 1-Benzyl-1,4-diazepan-5-one (2.00 g, 9.79 mmol) was dissolved in THF (40 mL), LiAlD4 (9.80 mL, 2.0 M in THF, 19.6 mmol) was added dropwise over 5 min and the reaction mixture was stirred for 24 h. The reaction mixture was quenched with sat aq NaHCO3, filtered and concentrated in vacuo to give the crude title compound (1.80 g, 96%) as a pale yellow gum.
-
- Intermediate 39 (800 mg, 3.42 mmol) and Intermediate 151 (988 mg, 5.14 mmol) were dissolved in NMP (2 mL) and the reaction mixture was heated using a microwave (200° C., absorption high) for 3 h. The residue was purified by reverse phase HPLC to give the title compound (320 mg, 24%) as a pale yellow gum. LCMS (ES+): 390.4 [MH]+.
- Intermediates 153-156 were prepared similarly to Intermediate 152, by reacting 6-chloro-2-substituted pyridines with substituted homopiperazines; see Table 10 below.
-
TABLE 10 Preparation of piperidin-4-one intermediates SMs/ LCMS Int Structure yield (ES+) Intermediate Name 153 Int 38 Int 151 48% 277.4 [MH]+ 6-(4-Benzyl-7,7- dihydrogenio-1,4-diazepan-1- yl)-N- (cyclopropylmethyl)pyridine- 2-carboxamide 154 Int 39 312.4 [MH]+ 6-(6-Methyl-1,4-diazepan-1- yl)-N-(pyridin-4-yl)pyridine-2- carboxamide 53% 155 Int 38 291.1 [MH]+ N-(Cyclopropylmethyl)-6-(6- hydroxy-1,4-diazepan-1- yl)pyridine-2-carboxamide 47% 156 Int 38 289.4 [MH]+ N-(Cyclopropylmethyl)-6-(5- methyl-1,4-diazepan-1- yl)pyridine-2-carboxamide -
- Intermediate 152 (315 mg, 0.81 mmol) was dissolved in MeOH (60 mL) and hydrogenated using an H-Cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C. The solvents were removed in vacuo to give the crude title compound (186 mg, 77%) as a white solid. LCMS (ES+): 300.5 [MH]+.
-
- Intermediate 158 was prepared similarly to Intermediate 157, using Intermediate 153 instead of Intermediate 152, to give the title compound (48%) as a light yellow gum. LCMS (ES+): 277.4 [MH]+.
-
- Intermediate 151 (150 mg, 0.78 mmol), 1-(propan-2-yl)piperidin-4-one (110 mg, 0.78 mmol) and NaBH(OAc)3 (496 mg, 2.34 mmol) were dissolved in DCM (15 mL) and stirred for 4 d. The reaction mixture was diluted with DCM (25 mL), washed with sat aq Na2CO3 (40 mL), brine xxx(40 mL), dried (MgSO4) and stirred with isocyanate resin for 3 h. The reaction mixture was filtered and the solvents removed in vacuo. The residue was dissolved in MeOH (25 mL) and hydrogenated using an H-Cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C. The solvents were removed in vacuo to give the crude title compound (135 mg, 76%) as a colourless gum. LCMS (ES+): 228.5 [MH]+.
-
- 1-Benzyl-3-methyl-piperidin-4-one (5.00 g, 24.6 mmol) was dissolved in CHCl3 (50 mL), the reaction mixture was cooled to 0° C. and conc H2SO4 (12 mL) was added dropwise. NaN3 (3.20 g, 49.2 mmol) was added portionwise over 10 min and the reaction mixture was stirred at room temperature for 18 h and at 50° C. for 2 h. Iced water (120 mL) was added and the reaction mixture was neutralized with NaOH, extracted with DCM (2×50 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (4.86 g, 91%) as an off-white solid. LCMS (ES+): 219.3 [MH]+.
-
- Intermediate 160 (4.86 g, 22.3 mmol) was dissolved in Et2O (100 mL) and LiAlH4 (11.7 mL, 4.0 M in Et2O, 46.8 mmol) was added dropwise over 10 min. The reaction mixture was stirred for 4, quenched with water, filtered, dried (MgSO4) and concentrated in vacuo to give the crude title compound (4.15 g, 91%) as a colourless gum. LCMS (ES+): 205.3 [MH]+.
-
- Intermediate 162 was prepared similarly to Intermediate 161, using LiAlD4 instead of LiAlH4, to give the crude title compound (84%) as a light yellow gum. LCMS (ES+): 207.3 [MH]+.
- Intermediates 163-172 were prepared similarly to Intermediate 159, by reductive alkylation of substituted benzyl homopiperazines with the appropriate ketone and subsequent debenzylation; see Table 11 below.
-
TABLE 11 Preparation of piperidin-4-yl-homopiperazine intermediates LCMS Int Structure SMs/Yield (ES+) Intermediate Name 163 Int 151 286.5 [MH]+ tert-Butyl 4-(7,7-dihydrogenio- 1,4-diazepan-1-yl)piperidine-1- carboxylate °99% 164 Int 151 Int 8 47% 242.3 [MH]+ 1-{1-[(2R)-Butan-2-yl]piperidin- 4-yl}-7,7-dihydrogenio-1,4- diazepane 165 Int 151 Int 9 75% 242.3 [MH]+ 1-{1-[(2S)-Butan-2-yl]piperidin- 4-yl}-7,7-dihydrogenio-1,4- diazepane 166 Int 151 Int 12 46% 282.3 [MH]+ 7,7-Dihydrogenio-1-{1-[(2S)- 1,1,1-trifluoropropan-2- yl]piperidin-4-yl}-1,4-diazepane 167 Int 151 Int 24 30% 254.3 [MH]+ 1-(1-Cyclopentylpiperidin-4-yl)- 7,7-dihydrogenio-1,4-diazepane 168 Int 161 ON-( 69% 240.4 [MH]+ 2-Methyl-1-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 169 Int 162 242.5 [MH]+ 7,7-Dihydrogenio-2-methyl-1-[1- (propan-2-yl)piperidin-4-yl]-1,4- diazepane 170 Int 162 Int 12 54% 296.5 [MH]+ 7,7-Dihydrogenio-2-methyl-1-{1- [(S)-1,1,1-trifluoropropan-2- yl]piperidin-4-yl}-1,4-diazepane 171 Int 162 300.3 [MH]+ tert-Butyl 4-(7,7-dihydrogenio-2- methyl-1,4-diazepan-1- yl)piperidine-1-carboxylate 172 252.2 [MH]+ 6-[1-(Propan-2-yl)piperidin-4-yl]- 3,6-diazabicyclo[3.2.2]nonane 65% * Commercially available -
- 2-Bromopyridine-6-carboxylic acid (5.00 g, 24.8 mmol) was dissolved in DCM (100 mL) and DMF (1 mL), and oxalyl chloride (7.54 g, 59.4 mmol) was added dropwise over 5 min. The reaction mixture was stirred for 2 h and the solvents were removed in vacuo. The reaction mixture was azeotroped twice with DCM and dissolved in DCM (100 mL). DIPEA (12.8 g, 99.0 mmol) and 4-aminopyridine (4.66 g, 49.5 mmol) were added dropwise and the reaction mixture was stirred for 2 h, washed with sat aq NaHCO3 (50 mL), dried (MgSO4) and concentrated in vacuo. The residue was recrystallised from MeOH to give the title compound (5.00 g, 73%) as an off white solid. LCMS (ES+): 278.2 [MH]+.
-
- Intermediate 174 was prepared similarly to Intermediate 173, using aminomethylcyclopropane instead of 4-aminopyridine, to give the title compound (77%) as a light yellow solid. LCMS (ES+): 255.2 [MH]+.
-
- Intermediate 163 (734 mg, 2.57 mmol), Intermediate 173 (650 mg, 2.34 mmol), caesium carbonate (1.14 g, 3.51 mmol), palladium acetate (37.0 mg, 0.16 mmol) and BINAP (146 mg, 0.23 mmol) were suspended in dioxane (10 ml). The reaction mixture was degassed for 15 min and heated at 95° C. for 18 h. The reaction mixture was concentrated in vacuo, dissolved in DCM, filtered and concentrated in vacuo. The residue was purified by column chromatography. The residue was dissolved in DCM (8 mL), TFA (4 mL) was added and the reaction mixture was stirred for 2 h. The solvents were removed in vacuo and the residue was partitioned between DCM (40 mL) and sat aq Na2CO3 (40 mL). The aq fraction was extracted with DCM (2×40 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the title compound (602 mg, 67%) as a yellow liquid. LCMS (ES+): 383.6 [MH]+.
-
- Intermediate 157 (75.0 mg, 0.25 mmol) and tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate (54.4 mg, 0.25 mmol) were dissolved in DCM (10 mL) and NaBH(OAc)3 (266 mg, 1.25 mmol) was added. The reaction mixture was stirred for 20 d, diluted with DCM (50 mL), washed with sat aq Na2CO3 (40 mL), brine (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC and dissolved in MeOH (10 mL) and TFA (1 mL). The reaction mixture was stirred for 18 h and the solvents were removed in vacuo to give the title compound.
-
- Intermediate 177 was prepared similarly to Intermediate 176, using Intermediate 113 instead of Intermediate 157, to give the crude title compound (100%) as a yellow liquid. LCMS (ES+): 399.2 [MH]+.
-
- Intermediate 151 (400 mg, 2.08 mmol), 3-fluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (452 mg, 2.08 mmol) and NaBH(OAc)3 (1.32 g, 6.24 mmol) were dissolved in DCM (25 mL) and stirred for 4 d. The reaction mixture was diluted with DCM (25 mL), washed with sat aq Na2CO3 (40 mL), brine (40 mL), dried (MgSO4) and stirred with isocyanate resin for 3 h. The reaction mixture was filtered and concentrated in vacuo to give the crude title compound (480 mg, 59%) as a colourless gum. LCMS (ES+): 394.5 [MH]+
-
- Intermediate 179 was prepared similarly to Intermediate 178, using 1-benzyl-1,4-diazepane instead of Intermediate 151, to give the crude title compound (42%) as a colourless gum. LCMS (ES+): 392.5 [MH]+
-
- Intermediate 178 (480 mg, 1.22 mmol) was dissolved in MeOH (20 mL) and TFA (2 mL) and stirred for 18 h. The solvents were removed in vacuo, the residue was dissolved in DCM (20 mL) and acetone (142 mg, 2.44 mmol) and NaBH(OAc)3 (1.29 g, 6.10 mmol) were added. The reaction mixture was stirred for 18 h, diluted with DCM (20 mL), washed with sat aq Na2CO3 (25 mL), dried (MgSO4) and stirred with isocyanate resin for 18 h. The reaction mixture was filtered and concentrated in vacuo to give the crude title compound (300 mg, 73%) as a colourless gum. LCMS (ES+): 336.5 [MH]+.
-
- Intermediate 181 was prepared similarly to Intermediate 180, using Intermediate 179 instead of Intermediate 178, to give the title compound (71%) as a white solid. LCMS (ES+): 334.5 [MH]+.
-
- Intermediate 180 was dissolved in MeOH (30 mL) and hydrogenated using an H-Cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C. The solvents were removed in vacuo to give the crude title compound (155 mg, 71%) as a colourless gum. LCMS (ES+): 246.4 [MH]+.
-
- Intermediate 183 was prepared similarly to Intermediate 182, using Intermediate 181 instead of Intermediate 180, to give the crude title compound (73%) as a colourless gum. LCMS (ES+): 244.4 [MH]+.
-
- Intermediate 135 (500 mg, 1.44 mmol), N,O-dimethylhydroxylamine hydrochloride (422 mg, 4.33 mmol), DIPEA (1.76 mL, 10.1 mmol) and HBTU (547 mg, 1.44 mmol) were dissolved in DMF (8 mL) and stirred for 20 h. The solvents were removed in vacuo and the residue was diluted with DCM (50 mL), washed with sat aq Na2CO3 (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (380 mg, 68%) as a white solid. LCMS (ES+): 390.5 [MH]+.
-
- Intermediate 185 was prepared similarly to Intermediate 175, using Intermediate 171 instead of Intermediate 163, to give the title compound (21%) as a yellow liquid. LCMS (ES+): 397.2 [MH]+.
-
- Intermediate 186 was prepared similarly to Intermediate 178, using 3-benzyl-3,6-diaza-bicyclo[3.2.2]nonane instead of Intermediate 151, to give the title compound (93%) as a pale yellow gum. LCMS (ES+): 418.4 [MH]+.
-
- Intermediate 187 was prepared similarly to Intermediate 180, using Intermediate 186 instead of Intermediate 178, to give the title compound (90%) as a pale yellow gum. LCMS (ES+): 360.4 [MH]+.
-
- Intermediate 188 was prepared similarly to Intermediate 182, using Intermediate 187 instead of Intermediate 180, to give the title compound (44%) as a pale yellow gum. LCMS (ES+): 270.4 [MH]+.
-
- Intermediate 189 was prepared similarly to Intermediate 186, using tert-butyl 4-oxopiperidine-1-carboxylate instead of 3-fluoro-4-oxo-piperidine-1-carboxylic acid tert-butyl ester, to give the crude title compound as a yellow liquid. LCMS (ES+): 400.3 [MH]+.
-
- Intermediate 189 (1.29 g, 3.24 mmol) was dissolved in MeOH (100 mL) and hydrogenated using an H-cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C. The solvents were removed in vacuo and the residue was purified by column chromatography to give the title compound (596 mg, 60%) as a yellow gum. LCMS (ES+): 310.3 [MH]+.
-
- Intermediate 191 was prepared similarly to Intermediate 175, using Intermediate 190 instead of Intermediate 163, to give the crude title compound (42%) as a yellow liquid. LCMS (ES+): 407.2 [MH]+.
-
- 10-Benzyl-3,10-diaza-bicyclo[4.3.1]decane (785 mg, 3.41 mmol), Intermediate 174 (790 mg, 3.10 mmol), cesium carbonate (1.00 g, 3.04 mmol), palladium acetate (45.0 mg, 0.20 mmol) and BINAP (192 mg, 0.31 mmol) were suspended in dioxane (25 mL), degassed and heated at 95° C. for 18 h. The solvents were removed in vacuo, the residue was diluted with DCM, filtered and concentrated in vacuo. The residue was purified by column chromatography, dissolved in EtOH (20 mL) and hydrogenated using a hydrogen balloon at 50° C. over 10% Pd(OH)2/C for 60 h. The reaction mixture was filtered through celite, washing with EtOH and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (89.0 mg, 49%).
-
- Intermediate 193 was prepared similarly to Intermediate 192, using Intermediate 39 instead of Intermediate 174, to give the crude title compound (28%) as a yellow gum. LCMS (ES+): 338.5 [MH]+.
-
- 6-Chloro-3-methylpyridine-2-carboxylic acid (595 mg, 3.47 mmol), aminomethylcyclopropane (356 μL, 4.16 mmol), EDC.HCl (1.46 g, 7.63 mmol), HOBN (1.54 g, 8.67 mmol) and NEM (1.10 mL, 8.67 mmol) were dissolved in DCM (30 mL) and stirred for 16 h. The reaction mixture was washed with sat aq NaHCO3 (30 mL), 1M aq HCl (30 mL), brine (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (215 mg, 28%) as a yellow solid. LCMS (ES+): 225.5 [MH]+.
-
- Intermediate 195 was prepared similarly to Intermediate 81, using Intermediate 194 instead of Intermediate 38, to give the crude title compound as a yellow liquid. LCMS (ES+): 289.2 [MH]+.
-
- 2-Bromothiazole (1.00 g, 6.10 mmol) and homopiperazine (2.44 g, 24.4 mmol) were dissolved in DMA (1 mL) and heated using a microwave (180° C., absorption high) for 30 min. The reaction mixture was dissolved in DCM (50 mL), washed with sat aq Na2CO3 (50 mL), brine (50 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (1.05 g, 94%) as a yellow solid. LCMS (ES+): 184.2 [MH]+.
-
- Tert-butyl 6-chloropyridine-2-carboxylate (1.00 g, 4.68 mmol) and N-benzylpiperidin-4-ol (1.88 g, 9.83 mmol) were dissolved in dioxane (10 mL). NaH (393 mg, 60% dispersion in mineral oil, 9.83 mmol) was added and the reaction mixture was heated using a microwave (80° C., absorption high) for 1 h. The solvents were removed in vacuo and the residue was dissolved in MeOH (100 mL), filtered and concentrated in vacuo. The residue was purified by reverse phase column chromatography to give the title compound (860 mg, 59%) as a white solid. LCMS (ES+): 313.1 [MH]+.
-
- Intermediate 197 (430 mg, 1.38 mmol) was dissolved in DCM (20 mL) and oxalyl chloride (419 mg, 3.30 mmol) was added. The reaction mixture was stirred for 2 h, the solvents were removed in vacuo and the residue was dissolved in DCM (20 mL). DIPEA (711 mg, 5.51 mmol) and 4-aminopyridine (259 mg, 2.75 mmol) were added and the reaction mixture was stirred for 3 h. The reaction mixture was diluted with DCM (50 mL), washed with sat aq Na2CO3 (75 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (360 mg, 67%) as a white solid. LCMS (ES+): 389.2 [MH]+.
-
- Intermediate 198 (360 mg, 0.93 mmol) was dissolved in MeOH (30 mL) and the reaction mixture was hydrogenated using an H-Cube (80 bar, 60° C., 1.0 mL/min) over 10% Pd/C. The solvents were removed in vacuo to give the crude title compound (231 mg, 84%) as a white solid. LCMS (ES+): 299.2 [MH]+.
-
- Intermediate 199 (77.0 mg, 0.26 mmol) was dissolved in DCM (6 mL) and N-Boc-hexahydro-1H-azepine-4-one (110 mg, 0.52 mmol) and NaBH(OAc)3 (273 mg, 1.30 mmol) were added. The reaction mixture was stirred for 4 d, diluted with DCM (10 mL), washed with sat aq Na2CO3 (10 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (6 mL), TFA (3 mL) was added and the reaction mixture was stirred for 2 h. The reaction mixture was concentrated in vacuo, dissolved in DCM (10 mL), washed with sat aq Na2CO3 (10 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (102 mg, 100%) as a yellow liquid. LCMS (ES+): 396.2 [MH]+.
-
- Intermediate 39 (250 mg, 1.07 mmol), 3-amino-piperidine-1-carboxylic acid tert-butyl ester (515 μL, 2.67 mmol) and DIPEA (746 μL, 4.28 mmol) were dissolved in NMP (2 mL) and heated using a microwave (185° C., absorption high) for 200 min. The reaction mixture was dissolved in DCM (20 mL), washed with sat aq NH4Cl (10 mL×5), dried (MgSO4) and concentrated in vacuo. The residue was partially purified by column to give the crude title compound as a brown oil. LCMS (ES+): 398.2 [MH]+.
-
- Intermediate 202 was prepared similarly to Intermediate 201, using Intermediate 38 instead of Intermediate 39 and 4-N-(tert-butoxycarbonyl)aminopiperidine instead of 3-amino-piperidine-1-carboxylic acid tert-butyl ester, to give the title compound (584 mg, 99%) as a white solid. LCMS (ES+): 375.7 [MH]+.
-
- Intermediate 202 (584 mg, 1.56 mmol) was dissolved in MeOH (2 mL) and HCl (4 mL, 2M in Et2O) was added. The reaction mixture was stirred for 16 h and the solvents were removed in vacuo to give the crude title compound (484 mg) as a light pink gum.
-
- Intermediate 66 (2.00 g, 9.10 mmol), (R)-pyrrolidin-3-yl-carbamic acid tert-butyl ester (5.08 g, 27.3 mmol) and DIPEA (6.34 mL, 36.4 mmol) were dissolved in DMA (40 mL) and the reaction mixture was heated using a microwave (180° C., absorption high) for 2 h. The solvents were removed in vacuo and the residue dissolved in DCM (100 mL), washed with sat aq Na2CO3 (50 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography, dissolved in DCM (8 mL) and TFA (4 mL) was added. The reaction mixture was stirred for 4 h, the solvents were removed in vacuo and the residue was de-salted using a 1VIP-TsOH SPE cartridge, eluting with 7 N ammonia in MeOH. The solvents were removed in vacuo to give the crude title compound (2.45 g) as a brown liquid. LCMS (ES+): 270.2 [MH]+.
-
- Intermediate 204 (400 mg, 1.49 mmol) and 1-(tert-butyoxycarbonyl)piperidine-4-carboxylic acid (341 mg, 1.49 mmol) were dissolved in DCM (5 mL) and DIPEA (0.65 mL, 3.71 mmol), EDC (346 mg, 2.23 mmol) and HONB (399 mg, 2.23 mmol) were added. The reaction mixture was stirred for 18 h and partitioned between DCM (50 mL) and sat aq Na2CO3 (30 mL). The aq fraction was extracted with DCM (2×20 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (241 mg, 34%) as a yellow liquid. LCMS (ES+): 481.1 [MH]+.
-
- Intermediate 205 (241 mg, 0.50 mmol) was dissolved in DCM (6 mL), TFA (3 mL) was added and the reaction mixture was stirred for 3 h. The solvents were removed in vacuo and the residue was de-salted using a MP-TsOH SPE cartridge, eluting with 7 N ammonia in MeOH. The solvents were removed in vacuo and the residue was dissolved in DCM (10 mL). Acetone (0.33 mL, 4.51 mmol) and NaBH(OAc)3 (1.06 g, 5.01 mmol) were added and the reaction mixture was stirred for 18 h and quenched with sat aq Na2CO3 (50 mL). DCM (50 mL) was added and the aq fraction was extracted with DCM (2×30 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (75.0 mg, 35%) as a yellow gum. LCMS (ES+): 423.2 [MH]+.
-
- Intermediate 207 was prepared similarly to Intermediate 204, using Intermediate 72 instead of Intermediate 66, to give the crude title compound as a brown liquid. LCMS (ES+): 284.3 [MH]+.
-
- (R)-Pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester (912 mg, 4.23 mmol), DIPEA (5.16 mL, 29.6 mmol), HBTU (1.61 g, 4.23 mmol) and Intermediate 207 (1.20 g, 4.23 mmol) were dissolved in DMF (10 mL) and stirred for 20 h. The reaction mixture was concentrated in vacuo, diluted with DCM (100 mL) and washed with sat aq Na2CO3 (50 mL). The aq fraction was extracted with DCM (2×100 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and dissolved in DCM (6 mL). TFA (3 mL) was added and the reaction mixture was stirred for 3 h. The reaction mixture was concentrated in vacuo and de-salted using an SCX cartridge, eluting with 7 N ammonia in MeOH. The reaction mixture was concentrated in vacuo to give the crude title compound (806 mg) as a brown solid. LCMS (ES+): 381.2 [MH]+.
-
- Intermediate 209 was prepared similarly to Intermediate 208, using (S)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester instead of (R)-pyrrolidine-1,3-dicarboxylicacid 1-tert-butyl ester, to give the crude title compound as a brown liquid. LCMS (ES+): 381.2 [MH]+.
-
- Intermediate 208 (269 mg, 0.71 mmol) was dissolved in DCM (10 mL), cyclopentanone (188 μL, 2.12 mmol) and NaBH(OAc)3 (749 mg, 3.53 mmol) were added and the reaction mixture was stirred for 18 h. The reaction mixture was quenched with sat aq Na2CO3 (30 mL) and diluted with DCM (30 mL). The aq fraction was extracted with DCM (2×20 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (52.0 mg, 16%) as a white solid. LCMS (ES+): 449.1 [MH]+.
-
- Intermediate 211 was prepared similarly to Intermediate 210, using Intermediate 209 instead of Intermediate 208, to give the title compound (68.0 mg, 24%) as a yellow gum. LCMS (ES+): 449.1 [MH]+.
-
- Intermediate 212 was prepared similarly to Intermediate 204, using Intermediate 39 instead of Intermediate 66, to give the crude title compound as a white solid. LCMS (ES+): 284.2 [MH]+.
-
- Intermediate 212 (500 mg, 1.76 mmol) was dissolved in DCM (15 mL). Benzyl (3R)-3-formylpyrrolidine-1-carboxylate (412 mg, 1.76 mmol) and NaBH(OAc)3 (411 mg, 1.94 mmol) were added and the reaction mixture was stirred overnight. The reaction mixture was diluted with DCM (10 mL), quenched with water (5 mL) and the organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and dissolved in MeOH (21 mL). The solution was hydrogenated using an H-Cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C. The solvents were removed in vacuo to give the crude title compound (300 mg, 80%). LCMS (ES+): 367.3 [MH]+.
-
- Intermediate 214 was prepared similarly to Intermediate 213, using benzyl (3S)-3-formylpyrrolidine-1-carboxylate instead of benzyl (3R)-3-formylpyrrolidine-1-carboxylate, to give the crude title compound as a yellow gum (93%). LCMS (ES+): 367.3 [MH]+.
-
- Intermediate 212 (500 mg, 1.76 mmol) was dissolved in DCM (20 mL) and 4-formylpiperidine-1-carboxylic acid tert-butyl ester (376 mg, 1.76 mmol) and NaBH(OAc)3 (748 mg, 3.52 mmol) were added. The reaction mixture was stirred at for 18 h, diluted with DCM (100 mL) and quenched with water (50 mL). The organic fraction was washed with sat aq Na2CO3 (50 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography, dissolved in DCM (40 mL) and TFA (10 mL) was added. The reaction mixture was stirred for 6 h and de-salted using a MP-TsOH SPE cartridge, eluting with 7 N ammonia in MeOH, to give the crude title compound as a yellow gum. LCMS (ES+): 381.2 [MH]+.
-
- Intermediate 66 (770 mg, 3.51 mmol), ethylene diamine (1.17 mL, 17.5 mmol) and DIPEA (2.44 mL, 14.0 mmol) were dissolved in NMP (13 mL) and the reaction mixture was heated using a microwave (200-220° C., absorption high) for 80 min. Further ethylene diamine (1.17 mL, 17.5 mmol) was added and the reaction mixture was heated using a microwave (220° C., absorption high) for 50 min. The reaction mixture was diluted with DCM (20 mL), washed with sat aq Na2CO3 (20 mL), dried (MgSO4) and concentrated in vacuo. The residue was partially purified by column chromatography to give the crude title compound (1.20 g) as a yellow gum. LCMS (ES+): 244.2 [MH]+.
- Intermediates 217-223 were prepared similarly to Intermediate 216, by SNAr reaction of amines with 6-chloro-2-substituted pyridines; see Table 12 below.
-
TABLE 12 SNAr reactions of amines with 6-chloro-2-substituted pyridines SMs/ LCMS Int Structure Yield (ES+) Intermediate Name 217 Int 63 94% 232.2 [MH]+ N-(2-Aminoethyl)-6-(5-ethyl-1H- imidazol-2-yl)pyridin-2-amine 218 Int 72 95% 258.3 [MH]+ N-(2-Aminoethyl)-6-(5- cyclopropyl-4-methyl-1H- imidazol-2-yl)pyridin-2-amine 219 Int 39 Used crude 258.3 [MH]+ 6-[(2-Aminoethyl)amino]-N- (pyridin-4-yl)pyridine-2- carboxamide 220 Int 39 Used crude 286.4 [MH]+ 6-{Methyl[2- (methylamino)ethyl]amino}-N- (pyridin-4-yl)pyridine-2- carboxamide 221 Int 39 Used crude 272.4 [MH]+ 6-[(3-Aminopropyl)amino]-N- (pyridin-4-yl)pyridine-2- carboxamide 222 Int 39 78% 284.4 [MH]+ 6-(Piperazin-1-yl)-N-(pyridin-4- yl)pyridine-2-carboxamide 223 Int 72 64% 284.2 [MH]+ 1-[6-(5-Cyclopropyl-4-methyl- 1H-imidazol-2-yl)pyridin-2- yl]piperazine -
- Pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester (221 mg, 1.03 mmol), DIPEA (1.25 mL, 7.19 mmol), HBTU (390 mg, 1.03 mmol) and Intermediate 216 (250 mg, 1.03 mmol) were dissolved in DMF (10 mL) and stirred for 20 h. The solvents were removed in vacuo and the residue was diluted with DCM (20 mL) and washed with sat aq Na2CO3 (10 mL). The aq fraction was extracted with DCM (2×20 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (335 mg, 74%) as a yellow gum. LCMS (ES+): 441.1 [MH]+.
-
- Intermediate 224 (335 mg, 0.76 mmol) was dissolved in DCM (4 mL), TFA (1 mL) was added and the reaction mixture was stirred for 2 h. The solvents were removed in vacuo and the residue was partitioned between DCM (20 mL) and 1M aq NaOH (20 mL). The aq fraction was basified to pH 14 with NaOH and extracted with DCM (3×50 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo. Half of the residue was dissolved in DCM (5 mL) and cyclopentanone (60.0 μL, 0.57 mmol) and NaBH(OAc)3 (161 mg, 0.76 mmol) were added. The reaction mixture was stirred overnight, diluted with DCM (10 mL) and quenched with water (5 mL). The organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (150 mg) as a yellow oil. LCMS (ES+): 409.2 [MH]+.
-
- Intermediate 226 was prepared similarly to Intermediate 208, using Intermediate 218 instead of Intermediate 207, to give the crude title compound as a yellow gum. LCMS (ES+): 355.2 [MH]+.
-
- Intermediate 227 was prepared similarly to Intermediate 210, using Intermediate 226 instead of Intermediate 208, to give the crude title compound (91%) as a yellow gum. LCMS (ES+): 423.2 [MH]+.
-
- Intermediate 216 (300 mg, 1.23 mmol) was dissolved in DCM (5 mL) and tert-butyl 3-oxopiperidine-1-carboxylate (270 mg, 1.36 mmol) and NaBH(OAc)3 (523 mg, 2.47 mmol) were added. The reaction mixture was stirred overnight, diluted with DCM (10 mL) and quenched with water (5 mL). The organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (226 mg, 43%) as a yellow gum. LCMS (ES+): 427.1 [MH]+.
- Intermediates 229-233 were prepared similarly to Intermediate 228, by reductive alkylation of Intermediates 216, 218 and 219; see Table 13 below.
-
TABLE 13 Reductive alkylation of Intermdiates 205, 207 and 208 SMs/ LCMS Int Structure Yield (ES+) Intermediate Name 229 Int 218 47% 441.2 [MH]+ tert-Butyl 3-[(2-{[6-5- cyclopropyl-4-methyl-1H- imidazol-2-yl)pyridin-2- yl]amino}ethyl)amino]piperidine- 1-carboxylate 230 Int 218 63% 441.2 [MH]+ tert-Butyl 4-[(2-{[6-5(5- cyclopropyl-4-methyl-1H- imidazol-2-yl)pyridin-2-yl] amino}ethyl)amino]piperidine-1- carboxylate 231 Int 216 55% 413.1 [MH]+ tert-Butyl 3-[2-{[6-(5- cyclopropyl-1H-imidazol-2- yl)pyridin-2-yl] amino}ethyl)aminolpyrrolidine- 1-carboxylate 232 Int 219 Used crude 455.2 [MHI+ tert-Butyl 4-{[2-({6-[(pyridin-4- yl)carbamoyl]pyridin-2-yl} amino)ethyl]amino}azepane-1- carboxylate 233 Int 218 64% 455.2 [MH]+ tert-Butyl 4-[(2-{[6-5- cyclopropyl-4-methyl-1H- imidazol-2-yl)pyridin-2-yl] amino}ethyDaminolazepane-1- carboxylate -
- Intermediate 234 was prepared similarly to Intermediate 224, using 3-tert-butoxycarbonylaminopropionic acid instead of pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester, to give the crude title compound (61%) as a yellow gum. LCMS (ES+): 415. [MH]+.
-
- Intermediate 235 was prepared similarly to Intermediate 225, using Intermediate 234 instead of Intermediate 224, to give the crude title compound (77%) as a pale yellow oil. LCMS (ES+): 383.2 [MH]+.
-
- N-Boc-hexahydro-1H-azepine-4-one (3.00 g, 14.1 mmol) was dissolved in DCM (50 mL), TFA (15 mL) was added and the reaction mixture was stirred for 2 h. The solvents were removed in vacuo and the residue partitioned between DCM (500 mL) and sat aq Na2CO3 (500 mL). The aq fraction was extracted with DCM (2×250 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (50 mL) and acetone (10 mL) and NaBH(OAc)3 (2.18 g, 141 mmol) were added. The reaction mixture was stirred for 18 h, diluted with DCM (200 mL) and quenched with sat aq Na2CO3 (150 mL). The organic fraction was dried (MgSO4) and concentrated in vacuo to give the crude title compound (2.18 g) as a brown liquid. LCMS (ES+): 156.2 [MH]+.
-
- Intermediate 222 (1.88 g, 6.64 mmol) was dissolved in DCM (125 mL) and tert-butyl 4-oxoazepane-1-carboxylate (2.12 g, 9.95 mmol) and NaBH(OAc)3 (7.03 g, 33.2 mmol) were added. The reaction mixture was stirred for 20 h, diluted with DCM (50 mL), washed with sat aq Na2CO3 (75 mL), brine (50 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (100 mL), shaken with isocyanate resin (4 g) for 1.5 h, filtered and concentrated in vacuo.
- The residue was purified by reverse phase column chromatography to give the title compound (2.17 g, 68%) as a white solid. LCMS (ES+): 481.5 [MH]+.
-
- Intermediate 237 (1.88 g, 6.64 mmol) was dissolved in DCM (100 mL), TFA (15 mL) was added and the reaction mixture was stirred for 20 h. The solvents were removed in vacuo and the residue was purified reverse by phase column chromatography to give the title compound (3.94 g, 71%) as a dark red solid. LCMS (ES+): 381.5 [MH]+.
-
- Intermediate 82 (130 mg, 0.47 mmol) was dissolved in DCM (6 mL) and 2-formyl-morpholine-4-carboxylic acid tert-butyl ester (111 mg, 0.52 mmol) and NaBH(OAc)3 (498 mg, 2.40 mmol) were added. The reaction mixture was stirred overnight. Further 2-formyl-morpholine-4-carboxylic acid tert-butyl ester (50.6 mg, 0.24 mmol) and NaBH(OAc)3 (50.9 mg, 0.24 mmol) were added and the reaction mixture was stirred overnight. The reaction mixture was diluted with DCM (10 mL), quenched with water (5 mL) and the organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was partially purified by column chromatography to give the title compound as a yellow oil (156 mg, 70%). LCMS (ES+): 476.4 [MH]+.
-
- Intermediate 240 was prepared similarly to Intermediate 237, using Intermediate 223 instead of Intermediate 222, to give the crude title compound (56%) as a pale yellow gum. LCMS (ES+): 481.3 [MH]+.
-
- 4-N-Boc-morpholine-3-acetic acid (500 mg, 2.04 mmol) and benzyl homopiperazine (388 mg, 2.04 mmol) were dissolved in DMF (20 mL) and cooled to 0° C. DIPEA (553 mg, 4.28 mmol) and HBTU (773 mg, 2.04 mmol) were added and the reaction mixture was stirred for 2 h. The solvents were removed in vacuo and the residue was partitioned between DCM (100 mL) and water (50 mL). The organic fraction was washed with 1 M aq Na2CO3 (25 mL), brine (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase column chromatography to give the title compound (730 mg, 86%) as a light yellow gum. LCMS (ES+): 418.4 [MH]+.
-
- Intermediate 241 (730 mg, 1.75 mmol) was dissolved in DCM (20 mL) and TFA (2 mL) was added. The reaction mixture was stirred for 16 h and concentrated in vacuo. The residue was dissolved in DCM (20 mL) and acetone (1 mL) was added. The reaction mixture was stirred for 30 min, NaBH(OAc)3 (1.11 g, 5.25 mmol) was added and the reaction mixture was stirred for 6 d. The reaction mixture was diluted with DCM (50 mL), washed with sat aq Na2CO3 solution (25 mL), brine (25 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (0.62 g, 99%) as a light yellow gum. LCMS (ES+): 360.5 [MH]+.
-
- Intermediate 242 (0.62 g, 1.73 mmol) was dissolved in THF (20 mL), LiAlH4 (0.71 mL, 2.4 M THF, 1.70 mmol) was added and the reaction mixture was stirred for 16 h. The reaction mixture was quenched with brine (10 mL) and partitioned between DCM (50 mL) and water (20 mL). The aq fraction was extracted with DCM (2×20 mL) and the combined organic fractions were washed with brine (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was hydrogenated using an H-Cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C to give the title compound (0.42 g, 95%) as a yellow gum. LCMS (ES+): 256.5 [MH]+.t
-
- 3-Bromo-1-propanol (100 mg, 0.72 mmol), K2CO3 (249 mg, 1.80 mmol) and 1,2,3,4-tetrahydrisoquinoline (95.8 mg, 0.72 mmol) were dissolved in MeCN (2 mL) and the reaction mixture was heated at 60° C. for 18 h. The reaction mixture was filtered and concentrated in vacuo. The residue was dissolved in DCM (10 mL) and methanesulphonyl chloride (82.4 mg, 0.72 mmol) and Et3N (87.4 mg, 0.86 mmol) were added. The reaction mixture was stirred for 1 h, diluted with DCM (20 mL), washed with sat aq NaHCO3 (20 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (72.2 mg) as a colourless gum. LCMS (ES+): 270.3 [MH]+.
-
- Intermediate 245 was prepared similarly to Intermediate 244, using 3,3-difluoropyrrolidine hydrochloride instead of 1,2,3,4-tetrahydrisoquinoline, to give the title compound (150 mg, 86%) as a colourless gum. LCMS (ES+): 244.2 [MH]+.
-
- Intermediate 87 (500 mg, 1.61 mmol) and NaHCO3 (141 mg, 1.69 mmol) were suspended in EtOH (20 mL), epichlorohydrin (156 mg, 1.69 mmol) was added and the reaction mixture was stirred for 2 d. Further epichlorohydrin (78.0 mg, 0.85 mmol) was added and the reaction mixture was stirred for 3 d. The reaction mixture was concentrated in vacuo and purified by column chromatography to give the title compound (206 mg, 32%) as a white solid. LCMS (ES+): 404 [MH]+.
-
- (S)-4-Boc-2-piperazinecarboxylic acid (530 mg, 2.17 mmol) was dissolved in MeOH (25 mL) and formaldehyde (1.76 mL, 37 wt % in water, 21.7 mmol) was added. The reaction mixture was stirred for 30 min, NaBH(OAc)3 (0.92 g, 4.34 mmol) was added and the reaction mixture was stirred for 2 h. The solvents were removed in vacuo and the residue was purified by reverse phase column chromatography. The residue and benzyl homopiperazine (0.41 g, 2.17 mmol) were dissolved in DMF (20 mL) and cooled to 0° C. DIPEA (0.59 g, 4.56 mmol) and HBTU (0.82 g, 2.17 mmol) were added and the reaction mixture was stirred for 3 h. The solvents were removed in vacuo and the residue was partitioned between DCM (100 mL) and water (50 mL). The organic fraction was washed with 1M aq Na2CO3 (25 mL), brine (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase column chromatography to give the title compound (0.64 g, 71%) as a light yellow gum. LCMS (ES+): 417.4 [MH]+.
-
- Intermediate 247 (0.64 g, 1.54 mmol) was dissolved in DCM (20 mL), TFA (2 mL) was added and the reaction mixture was stirred for 16 h. The solvents were removed in vacuo and the residue was dissolved in DCM (20 mL) and acetone (1 mL) was added. The reaction mixture was stirred for 30 min and NaBH(OAc)3 (0.98 g, 4.63 mmol) was added. The reaction mixture was stirred for 1.5 h, diluted with DCM (50 mL), washed with sat aq Na2CO3 (25 mL), brine (25 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (0.46 g, 82%) as a light yellow gum. LCMS (ES+): 359.5 [MH]+.
-
- Intermediate 248 (0.46 g, 1.27 mmol) was dissolved in THF (20 mL) and LiAlH4 (0.54 mL, 2.4 M in THF, 1.27 mmol) was added. The reaction mixture was stirred for 16 h, quenched with brine (10 mL) and partitioned between DCM (50 mL) and water (20 mL). The aq fraction was extracted with DCM (2×20 mL) and the combined organic fractions were washed with brine (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was hydrogenated using an H-Cube (80 bar, 60° C., 1 mL/min) over 10% Pd/C to give the title compound (0.29 g, 89%) as a yellow gum. LCMS (ES+): 255.5 [MH]+.
-
- (S)—N-Boc-2-morpholine carboxylic acid (2.00 g, 8.65 mmol) was dissolved in THF (30 mL) and borane (25.9 mL, 1.0 M in THF, 25.9 mmol) was added dropwise. The reaction mixture was heated at reflux for 2.5 h and quenched with water (10 mL). The reaction mixture was concentrated in vacuo and the residue dissolved in DCM (30 mL), washed with sat aq Na2CO3 (2×20 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (1.74 g, 92%) as a pale yellow oil. LCMS (ES+): 240.3 [MH]+.
-
- Intermediate 250 (500 mg, 2.30 mmol) and IBX (1.29 g, 4.60 mmol) were dissolved in DCE (20 mL) and heated at 70° C. for 18 h. The reaction mixture was filtered, washed with sat aq Na2CO3 (10 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (684 mg) as a pale yellow oil.
-
- Intermediate 83 (150 mg, 0.50 mmol) was dissolved in DCM (6 mL) and Intermediate 251 (119 mg, 0.55 mmol) and NaBH(OAc)3 (535 mg, 2.52 mmol) were added. The reaction mixture was stirred overnight. Further Intermediate 251 (52.7 mg, 0.25 mmol) and NaBH(OAc)3 (51.9 mg, 0.25 mmol) were added and the reaction mixture was stirred for 2 h. The reaction mixture was diluted with DCM (10 mL) and quenched with water (5 mL). The organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound as a yellow oil (211 mg, 84% yield).
-
- Intermediate 81 (150 mg, 0.55 mmol), N-(3-bromopropyl)-phthalimide (147 mg, 0.55 mmol) and K2CO3 (113 mg, 0.82 mmol) were dissolved in MeCN (2 mL) and the reaction mixture was stirred at 60° C. for 12 h. The reaction mixture was filtered, washed with DCM, stirred with isocyanate resin for 2 h, filtered and concentrated in vacuo to give the title compound (240 mg, 95%) as a pale yellow gum. LCMS (ES+): 462.8 [MH]+.
-
- 2-Chloropyridine (3.00 g, 26.4 mmol), DIPEA (9.20 mL, 52.8 mmol) and homopiperazine (7.90 g, 79.3 mmol) were dissolved in DMA (10 mL) and heated using a microwave (180-200° C., absorption high) for 40 min. The reaction mixture was diluted with DCM (150 mL), washed with sat aq Na2CO3 (100 mL), brine (100 mL), dried (MgSO4) and concentrated in vacuo to give the title compound (3.41 g, 72%) as a brown liquid. LCMS (ES+): 178.6 [MH]+.
- Intermediates 255-257 were prepared similarly to Intermediate 254, by SNAr reaction of 2-chloropyridines with homopiperazine; see Table 14 below.
-
- Intermediate 254 (400 mg, 2.26 mmol) was dissolved in DCM (5 mL) and Boc-Piperidone (540 mg, 2.71 mmol) and NaBH(OAc)3 (2.39 g, 11.3 mmol) were added. The reaction mixture was stirred for 18 h, diluted with DCM (20 mL) and quenched with water (15 mL). The organic fraction was washed with sat aq Na2CO3 (10 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (2 mL), TFA (1 mL) was added and the reaction mixture was stirred for 3 h. The solvents were removed in vacuo and the residue dissolved in DCM (10 mL), washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo to give the crude title compound (361 mg, 61%) as a yellow solid. LCMS (ES+): 261.7 [MH]+.
- Intermediates 259-261 were prepared similarly to Intermediate 258, by reductive alkylation and deprotection of Intermediates 255-257; see Table 15 below.
-
TABLE 15 Preparation of 4-(piperidin-4-yl)-1,4-diazepan-1-yl]pyridine intermediates Int/ LCMS Int Structure Yield (ES+) Intermediate Name 259 Int 255 77% 275.7 [MH]+ 1-(6-Methylpyridin-2-yl)-4- (piperidin-4-yl)-1,4- diazepane 260 Int 256 41% 275.7 [MH]+ 1-(5-Methylpyridin-2-yl)-4- (piperidin-4-yl)-1,4- diazepane 261 Int 257 43% 275.8 [MH]+ 1-(4-Methylpyridin-2-yl)-4- (piperidin-4-yl)-1,4- diazepane -
- Intermediate 25 (10.0 g, 44.7 mmol) and Boc-homopiperazine (9.85 g 49.2 mmol) were dissolved in DCM (250 mL) and NaBH(OAc)3 (47.4 g, 224 mmol) was added portionwise. The reaction mixture was stirred for 18 h and quenched with water (200 mL). The organic fraction was washed with 1M aq Na2CO3 (200 mL), brine (100 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (11.0 g, 60%) as a colourless liquid. LCMS (ES+): 408.7 [MH]+.
-
- Intermediate 262 (11.0 g, 27.0 mmol) was dissolved in DCM (100 mL), TFA (10.0 mL, 135 mmol) was added and the reaction mixture was stirred for 16 h. The solvents were removed in vacuo and the residue was partitioned between DCM (200 mL) and water (200 mL). The aq fraction was basified to pH 14 with NaOH, extracted with DCM (3×100 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo to give the title compound (7.42 g, 89%) as a pale yellow liquid. LCMS (ES+): 308.7 [MH]+.
-
- 2-Bromothiazole-4-carboxylic acid (500 mg, 2.40 mmol), aminomethylcyclopropane (247 μL, 2.88 mmol), EDC.HCl (1.01 g, 5.29 mmol), HOBN (1.08 g, 6.01 mmol) and NEM (765 1, 11, 6.01 mmol) were dissolved in DCM (30 mL) and the reaction mixture was stirred for 16 h. The organic fraction was washed with sat aq NaHCO3 (30 mL), 1 M aq HCl (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (404 mg, 64%) as a white solid. LCMS (ES+): 261.4 [MH]+.
-
- Intermediate 265 was prepared similarly to Intermediate 264, using 2-chloro-4-methylpyrimidine-5-carboxylic acid instead of 2-bromothiazole-4-carboxylic acid and 1-(3-aminopropyl)imidazole instead of aminomethylcyclopropane, to give the crude title compound. LCMS (ES+): 280.5 [MH]+.
-
- 6-Chloro-4-methylpyridine-2-carboxylic acid (422 mg, 2.46 mmol) was dissolved in DCM (10 mL) and oxalyl chloride (422 μL, 4.92 mmol) and DMF (100 μL) were added. The reaction mixture was stirred for 3 h, the solvents were removed in vacuo and the residue was azeotroped with DCM. The residue was dissolved in DCM (10 mL), DIPEA (1.63 mL, 9.84 mmol) and aminomethylcyclopropane (427 μL, 4.92 mmol) were added and the reaction mixture was stirred for 1 h. The reaction mixture was diluted with DCM (40 mL), washed with sat aq NaHCO3 (50 mL), 1 M aq HCl (50 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography to give the title compound (494 mg, 69%) as a yellow liquid. LCMS (ES+): 225.5 [MH]+.
-
- Intermediate 267 was prepared similarly to Intermediate 264, using 2-chloroisonicotinic acid instead of 2-bromothiazole-4-carboxylic acid, to give the title compound (58%) as a pale yellow solid. LCMS (ES+): 211.5 [MH]+.
-
- Intermediate 268 was prepared similarly to Intermediate 81, using Intermediate 267 instead of Intermediate 38, to give the crude title compound as a yellow liquid. LCMS (ES+): 275.7 [MH]+.
-
- Intermediate 269 was prepared similarly to Intermediate 119, using Intermediate 268 instead of Intermediate 81, to give the title compound (37%) as a yellow liquid. LCMS (ES+): 358.7 [MH]+.
-
- Intermediate 270 was prepared similarly to Intermediate 264, using 6-chloro-5-methoxypyridine-2-carboxylic acid instead of 2-bromothiazole-4-carboxylic acid, to give the title compound (75%) as a colourless liquid. LCMS (ES+): 241.5 [MH]+.
-
- Intermediate 271 was prepared similarly to Intermediate 81, using Intermediate 270 instead of Intermediate 38, to give the crude title compound as a yellow liquid. LCMS (ES+): 305.7 [MH]+.
-
- Intermediate 272 was prepared similarly to Intermediate 119, using Intermediate 271 instead of Intermediate 81, to give the title compound (24%) as a yellow liquid. LCMS (ES+): 388.7 [MH]+.
-
- Intermediate 273 was prepared similarly to Intermediate 176, using tert-butyl 4-oxopiperidine-1-carboxylate instead of tert-butyl 3-fluoro-4-oxopiperidine-1-carboxylate, to give the crude title compound (100%) as a yellow liquid. LCMS (ES+): 383.5 [MH]+.
-
- Intermediate 274 was prepared similarly to Intermediate 201, using 4-N-(tert-butoxycarbonyl)aminopiperidine instead of 3-amino-piperidine-1-carboxylic acid tert-butyl ester, to give the crude title compound as a white solid. LCMS (ES+): 398.4 [MH]+.
-
- Intermediate 135 (75.0 mg, 0.22 mmol), EDC.HCl (91.3 mg, 0.48 mmol), HONB (97.0 mg, 0.54 mmol) and NEM (275 [tL, 2.16 mmol) were dissolved in DCM (1 mL). 4-Aminomethyltetrahydropyran (125 mg, 1.08 mmol) was added and the reaction mixture was stirred for 18 h. The reaction mixture was diluted with DCM (20 mL) and the organic fraction was washed with sat aq Na2CO3 (20 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (31.4 mg, 33%) as a colourless gum. HRMS (ESC′) calculated for C25H41N5O2: 443.326026, found 443.326896. HPLC: Rf 3.70 min, 100% purity.
-
- Intermediate 135 (650 mg, 1.88 mmol), 4-aminotetrahydropyran (210 mg, 2.07 mmol), DIPEA (970 mg, 7.52 mmol) and HBTU (710 mg, 1.88 mmol) were dissolved in DMF (10 mL) and the reaction mixture was stirred for 20 h. The solvents were removed in vacuo and the residue was diluted with DCM (100 mL), washed with sat aq Na2CO3 (10 mL), dried (MgSO4) and the solvents were removed in vacuo. The residue was purified by reverse phase HPLC and desalted (K2CO3 in DCM) to give the title compound (300 mg, 38%) as a colourless gum. HRMS (ESI+) calculated for C24H39N502: 429.310376, found 429.311726. HPLC: Rf 3.61 min, 100% purity.
-
- Intermediate 135.3TFA (217 mg, 0.32 mmol) was dissolved in DCM (3 mL), oxalyl chloride (232 μL, 2.70 mmol) and DMF (100 μL) were added and the reaction mixture was stirred for 5 h. The solvents were removed in vacuo and the residue was dissolved in DCM (3 mL). DIPEA (446 μL, 2.70 mmol) and 1-(3-aminopropyl)imidazole (129 μL, 1.08 mmol) were added and the reaction mixture was stirred for 2.5 d. DCM (30 mL) was added and the reaction mixture was washed with sat aq Na2CO3 (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC and column chromatography to give the title compound (7.16 mg, 6%) as a yellow gum. HRMS (ESI+) calculated for C25H39N70: 453.321609, found 453.320079. HPLC: Rf 3.92 min, 100% purity.
- Examples 4-58 were prepared similarly to Examples 1-2, by reacting Intermediates 135 and 136 with the appropriate amine; see Table 16 below.
-
TABLE 16 Preparation of amides from Intermediates 135 and 136 Int/ Proc/ Ex Structure Name Yield HRMS (ESI+), HPLC 4 N-Ethyl-6-{4-[1-(propan-2-yl) piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-carboxamide Int 135 B 28% HRMS (ESI+) calculated for C21H35N5O: 373.284161, found 373.285491. HPLC: Rf 3.53 min, 98.8% purity. 5 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- propylpyridine-2-carboxamide Int 135 B 19% HRMS (ESI+) calculated for C22H37N5O: 387.299811, found 387.300111. HPLC: Rf 3.77 min, 99.4% purity. 6 N-(2-Methylpropyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 A 23% HRMS (ESI+) calculated for C23H39N5O: 401.315461, found 401.316091. HPLC: Rf 4.03 min, 100% purity. 7 N-Butyl-6-{4-[1-(propan-2-yl) piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-carboxamide Int 135 B 46% HRMS (ESI+) calculated for C23H39N5O: 401.315461, found 401.316951. HPLC: Rf 4.05 min, 98.7% purity. 8 N-(2-Fluoroethyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 A 28% HRMS (ESI+) calculated for C21H34FN5O: 391.274739, found 391.276459. HPLC: Rf 3.51 min, 100% purity. 9 N-(2,2-Difluoroethyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 B 45% HRMS (ESI+) calculated for C21H33F2N5O: 409.265317, found 409.267177. HPLC: Rf 3.72 min, 100% purity. 10 6-{4-[1-(Propan-2-yl) piperidin-4-yl]-1,4-diazepan- 1-yl}-N-(2,2,2-trifluoroethyl) pyridine-2-carboxamide Int 135 A 42% HRMS (ESI+) calculated for C21H32F3N5O: 427.255895, found 427.256005. HPLC: Rf 4.07 min, 100% purity. 11 N-Cyclopropyl-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine- 2-carboxamide Int 135 B 34% HRMS (ESI+) calculated for C22H35N5O: 385.284161, found 385.285131. HPLC: Rf 3.58 min, 99.2% purity. 12 N-(2-Hydroxyethyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl pyridine-2- carboxamide Int 135 B 26% HRMS (ESI+) calculated for C21H35N5O2: 389.279075, found 389.280655. HPLC: Rf 3.22 min, 100% purity. 13 N-(2-Cyanoethyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 B 18% HRMS (ESI+) calculated for C22H34N6O: 398.27941, found 398.28101. HPLC: Rf 3.50 min, 100% purity. 14 N-(2-Methoxyethyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 A 11% HRMS (ESI+) calculated for C22H37N5O2: 403.294725, found 403.295825. HPLC: Rf 3.48 min, 100% purity. 15 N-(3-Methoxypropyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 B 5% HRMS (ESI+) calculated for C23H39N5O2: 417.310376, found 417.310116. HPLC: Rf 3.63 min, 100% purity. 16 N-[2-(Dimethylamino)ethyl]-6- {4-[1-(propan-2-yl)piperidin-4- yl]-1,4-diazepan-1-yl}pyridine- 2-carboxamide Int 135 B 8% HRMS (ESI+) calculated for C23H40N6O: 416.32636, found 416.32511. HPLC: Rf 3.06 min, 99.2% purity. 17 N-Methyl-N-(2-methylpropyl)- 6-{4-[1-(propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl} pyridine-2-carboxamide Int 135 B 10% HRMS (ESI+) calculated for C24H41N5O: 415.331111, found 415.330691. HPLC: Rf 4.06 min, 100% purity. 18 N-[(3S)-Oxolan-3-yl]-6-{4-[1- propan-2-yl)piperidin-4-yl]-1,4- diazepan-1-yl}pyridine-2- carboxamide Int 135 B 26% HRMS (ESI+) calculated for C23H37N5O2: 415.294725, found 415.296125. HPLC: Rf 3.51 min, 100% purity. 19 N-[(3R)-Oxolan-3-yl]-6-{4-[1- propan-2-yl)piperidin-4-yl]-1,4- diazepan-1-yl}pyridine-2- carboxamide Int 135 B 22% HRMS (ESI+) calculated for C23H37N5O2: 415.294725, found 415.295925. HPLC: Rf 3.50 min, 100% purity. 20 N-[(2R)-Oxolan-2-ylmethyl]- 6-{4-[1-(propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl} pyridine-2-carboxamide Int 135 A 32% HRMS (ESI+) calculated for C24H39N5O2: 429.310376, found 429.311996. HPLC: Rf 3.69 min, 100% purity. 21 1-[(6-{4-[1-(Propan-2-yl) piperidin-4-yl]-1,4-diazepan- 1-yl}pyridin-2-yl)carbonyl]- 2,3-dihydro-1H-indole Int 135 B 18% HRMS (ESI+) calculated for C27H37N5O: 447.299811, found 447.301341. HPLC: Rf 4.35 min, 99.2% purity. 22 2-[(6-{4-[1-(Propan-2-yl) piperidin-4-yl]-1,4-diazepan- 1-yl}pyridin-2-yl)carbonyl]- 1,2,3,4-tetrahydroisoquinoline Int 135 B 13% HRMS (ESI+) calculated for C28H39N5O: 461.315461, found 461.317701. HPLC: Rf 4.39 min, 100% purity. 23 N-Phenyl-6-{4-[1-(propan-2-yl) piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-carboxamide Int 135 B 34% HRMS (ESI+) calculated for C25H35N5O: 421.284161, found 421.285491. HPLC: Rf 4.38 min, 100% purity. 24 N-(2-Hydroxyphenyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 B 3% HRMS (ESI+) calculated for C25H35N50O: 437.279075, found 437.280385. HPLC: Rf 4.27 min, 98.9% purity. 25 N-(4-Chlorophenyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine- 2-carboxamide Int 135 B 22% HRMS (ESI+) calculated for C25H34C1N5O: 455.245188, found 455.245978. HPLC: Rf 4.81 min, 100% purity. 26 N-(4-Methoxyphenyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 B 3% HRMS (ESI+) calculated for C26H37N5O2: 451.294725, found 451.296235. HPLC: Rf 4.32 min, 99.7% purity. 27 N-(4-Methylphenyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 B 4% HRMS (ESI+) calculated for C26H37N5O: 435.299811, found 435.301201. HPLC: Rf 4.58 min, 99.7% purity. 28 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (pyridin-2-yl)pyridine-2- carboxamide Int 135 B 11% HRMS (ESI+) calculated for C24H34N6O: 422.27941, found 422.28007. HPLC: Rf 3.89 min, 100% purity. 29 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (pyridin-3-yl)pyridine-2- carboxamide Int 135 B 11% HRMS (ESI+) calculated for C24H34N6O: 422.27941, found 422.28131. HPLC: Rf 3.31 min, 99.7% purity. 30 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (pyridin-4-yl)pyridine-2- carboxamide Int 135 B 2% HRMS (ESI+) calculated for C24H34N6O: 422.27941, found 422.28131. HPLC: Rf 3.31 min, 99.7% purity. 31 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (1,3-thiazol-2-yl)pyridine-2- carboxamide Int 135 B 13% HRMS (ESI+) calculated for C22H32N6OS: 428.23583, found 428.23724. HPLC: Rf 4.15 min, 99.3% purity. 32 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (1,3-thiazol-5-yl)pyridine-2- carboxamide Int 135 B 79% HRMS (ESI+) calculated for C22H32N6OS; 429.24311, found 429.24149. HPLC: Rf 3.89 min, 100% purity. 33 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (pyridin-2-ylmethyl)pyridine-2- carboxamide Int 135 B 14% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29685. HPLC: Rf 3.18 min, 99.6% purity. 34 6-{4-[1-(Propan-2-yDpiperidin- 4-yl]-1,4-diazepan-1-yl}-N- (pyridin-3-ylmethyl)pyridine-2- carboxamide Int 135 B 36% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29575. HPLC: Rf 3.16 min, 99.7% purity. 35 N-Methyl-6-{4-[1-(propan- 2-yl)piperidin-4-yl]-1,4- diazepan-1-yl}-N- (pyridin-3-ylmethyl) pyridine-2-carboxamide Int 135 B 24% HRMS (ESI+) calculated for C26H38N6O: 450.31071, found 450.31217. HPLC: Rf 3.07 min, 98.7% purity. 36 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (pyridin-4-ylmethyl)pyridine- 2-carboxamide Int 135 B 6% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29701. HPLC: Rf 3.14 min, 100% purity. 37 N-[(1-Methyl-1H-imidazol- 2-yl)methyl]-6-{4-[1-(propan- 2-yl)piperidin-4-yl]-1,4- diazepan-1-yl}pyridine- 2-carboxamide Int 135 A 29% HRMS (ESI+) calculated for C24H37N7O: 439.305959, found 439.306099. HPLC: Rf 3.16 min, 100% purity. 38 N-(1,3-Oxazol-2-ylmethyl)- 6-{4-[1-(Propan-2-yl) piperidin-4-yl]-1,4-diazepan- 1-yl}pyridine-2-carboxamide Int 135 A 26% HRMS (ESI+) calculated for C23H34N6O2: 426.274324, found 426.275144. HPLC: Rf 3.55 min, 100% purity. 39 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (1,3-thiazol-2-ylmethyl) pyridine-2-carboxamide Int 135 B 34% HRMS (ESI+) calculated for C23H34N6OS: 442.25148, found 442.2535. HPLC: Rf 3.70 min, 100% purity. 40 N-(Furan-2-ylmethyl)-6-{4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide Int 135 B 7% HRMS (ESI+) calculated for C24H35N5O2: 425.279075, found 425.280715. HPLC: Rf 3.92 min, 100% purity. 41 N-(1,3-Oxazol-4-ylmethyl)-6- {4-[1-(propan-2-yl)piperidin-4- yl]-1,4-diazepan-1-yl}pyridine- 2-carboxamide Int 135 B 26% HRMS (ESI+) calculated for C23H34N6O2: 426.274324, found 426.272804. HPLC: Rf 3.51 min, 100% purity. 42 6-{4-[1-(Propan-2-yl) piperidin-4-yl]-1,4-diazepan- 1-yl}-N-(1,3-thiazol-4- ylmethyl)pyridine-2- carboxamide Int 135 B 12% HRMS (ESI+) calculated for C23H34N6OS: 442.25148, found 442.25304. HPLC: Rf 3.61 min, 100% purity. 43 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N- (1,3-thiazol-5-ylmethyl) pyridine-2-carboxamide Int 135 B 10%HRMS (ESI+) calculated for C23H34N6OS: 442.25148, found 442.25317. HPLC: Rf 3.24 min, 98.2% purity. 44 N-(1,3-Oxazol-5-ylmethyl)-6- {4-[1-(propan-2-yl)piperidin-4- yl]-1,4-diazepan-1-yl} pyridine-2-carboxamide Int 135 B 12% HRMS (ESI+) calculated for C23H34N6O2: 426.274324, found 426.275794. HPLC: Rf 3.19 min, 99.4% purity. 45 N-[2-(1H-Imidazol-1-yl)ethyl]- 6-{4-[1-(propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl} pyridine-2-carboxamide Int 135 A 24% HRMS (ESI+) calculated for C24H37N7O: 439.305959, found 439.306109. HPLC: Rf 3.14 min, 100% purity. 46 6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}-N-[2- (pyridin-2-yl)ethyl]pyridine- 2-carboxamide Int 135 B 12% HRMS (ESI+) calculated for C26H38N6O: 450.31071, found 450.3113. HPLC: Rf 3.19 min, 100% purity. 47 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(oxan-4- ylmethyl)pyridine-2- carboxamide Int 136 A 47% HRMS (ESI+) calculated for C29H40C1N5O2: 525.287053, found 525.284223. HPLC: Rf 3.96 48 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(2,2,2- trifluoroethyl)pyridine-2- carboxamide Int 136 A 50% HRMS (ESI+) calculated for C25H31C1F3N5O: 509.216923, found 509.218693. HPLC: Rf 4.40 49 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(3- methylbutyl)pyridine-2- carboxamide Int 136 A 56% HRMS (ESI+) calculated for C28H40C1N5O: 497.292139, found 497.290299. HPLC: Rf 4.66 min, 99.3% purity. 50 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(2- methoxyethyl)pyridine-2- carboxamide Int 136 A 56% HRMS (ESI+) calculated for C26H36C1N5O2: 485.255753, found 485.253443. HPLC: Rf 3.94 51 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-[(2R)- oxolan-2-ylmethyl] pyridine-2-carboxamide Int 136 A 48% HRMS (ESI+) calculated for C28H38C1N5O2: 511.271403, found 511.270223. HPLC: Rf 3.87 52 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(oxan-4-yl) pyridine-2-carboxamide Int 136 A 43% HRMS (ESI+) calculated for C28H38C1N5O2; 512.27868, found 512.2796. HPLC: Rf 3.82 min, 100% purity. 53 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl]-1,4- diazepan-1-yl)-N-(pyridine- 3-yl)pyridine-2-carboxamide Int 136 A 53% HRMS (EST+) calculated for C28H33C1N6O; 505.24771, found 505.2475. HPLC: Rf 3.61 min, 99.3% purity. 54 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(pyridine- 4-yl)pyridine-2-carboxamide Int 136 A 8% HRMS (ESI+) calculated for C28H33C1N6O: 504.240437, found 504.241067. HPLC: Rf 3.67 min, 100% purity. 55 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(pyridine- 3-ylmethyl)pyridine-2- carboxamide Int 136 A 38% HRMS (ESI+) calculated for C29H35C1N6O: 518.256087, found 518.254667. HPLC: Rf 3.49 min, 99.5% purity. 56 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(pyridine-4- ylmethyl)pyridine-2- carboxamide Int 136 A 39% HRMS (ESI+) calculated for C29H35C1N6O; 519.26336, found 519.26306. HPLC: Rf 3.39 min, 99.4 purity. 57 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(1,3-oxazol- 2-ylmethyl)pyridine-2- carboxamide Int 136 A 39% HRMS (ESI+) calculated for C27H33C1N6O2; 508.235352, found 508.23531. HPLC: Rf 3.85 58 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(1,3-oxazol- 2-ylmethyl)pyridine- 2-carboxamide Int 136 A 39% HRMS (ESI+) calculated for C27H33C1N6O2; 508.235352, found 508.235412. HPLC: Rf 3.91 -
- Intermediate 81 (100 mg, 0.36 mmol) and Intermediate 7 (64.6 mg, 0.36 mmol) were dissolved in DCM (10 mL) and NaBH(OAc)3 (386 mg, 1.82 mmol) was added. The reaction mixture was stirred for 4 d, diluted with DCM (50 mL), washed with sat aq Na2CO3 (40 mL), brine (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (2.80 mg, 2%) as a colourless gum. HRMS (ESI+) calculated for C23H35F2N5O: 435.280967, found 435.280897. HPLC: Rf 3.86 min, 100% purity.
- Examples 60-124 were prepared similarly to Examples 59, by reacting Intermediates 81-88, 90-115 and 117 with the appropriate piperidin-4-one derivative; see Table 17 below.
-
TABLE 17 Reductive alkylations of Intermediates 81-88, 90-115 and 117 Ex Structure Name Ints Yield HRMS (ESI+), HPLC 60 N-(Cyclopropylmethyl)-6-[4-(1- ethylpiperidin-4-yl)-1,4- diazepan-1-yl]pyridine-2- carboxamide 81, * 31% HRMS (ESI+) calculated for C22H35N5O: 385.284161, found 385.284971. HPLC: Rf 3.87 min, 99.5% purity. 61 N-(Cyclopropylmethyl)-6-[4-(1- propylpiperidin-4-yl)-1,4- diazepan-1-yl]pyridine-2- carboxamide 81, * 30% HRMS (ESI+) calculated for C23H37N5O: 399.299811, found 399.299541. HPLC: Rf 3.93 min, 100% purity. 62 N-(Cyclopropylmethyl)-6-[4-(1- cyclopropylpiperidin-4-yl)-1,4- diazepan-1-yl]pyridine-2- carboxamide 81, * 40% HRMS (ESI+) calculated for C23H35N5O: 397.284161, found 397.284451. HPLC: Rf 3.89 min, 99.8% purity. 63 N-(Cyclopropylmethyl)-6-{4-[1- (propan-2-y)piperidin-4-yl]-1,4- diazepan-1-yl}pyridine-2- carboxamide 81, * 36% HRMS (ESI+) calculated for C23H37N5O: 399.299811, found 399.300391. HPLC: Rf 3.90 min, 99.4% purity. 64 6-[4-(1-tert-Butylpiperidin-4-yl)- 1,4-diazepan-1-yl]-N- (cyclopropylmethyl)pyridine-2- carboxamide 81, * 14% HRMS (ESI+) calculated for C24H39N5O: 413.315461, found 413.315521. HPLC: Rf 3.90 min, 96.1% purity. 65 6-{4-[1-(Butan-2-yl)piperidin-4- yl]-1,4-diazepan-1-yl}-N- (cyclopropylmethyl)pyridine-2- carboxamide 81, 22 25% HRMS (ESI+) calculated for C24H39N5O: 413.315461, found 413.315641. HPLC: Rf 4.05 min, 99.7% purity. 66 N-(Cyclopropylmethyl)-6-{4-[1- (pentan-3-yl)piperidin-4-yl]-1,4- diazepan-1-yl}pyridine-2- carboxamide 81, 23 36% HRMS (ESI+) calculated for C25H41N5O: 427.331111, found 427.331491. HPLC: Rf 4.13 min, 100% purity. 67 N-(Cyclopropylmethyl)-6-{4-[1- (1-fluoropropan-2-yl)piperidin-4- yl]-1,4-diazepan-1-yl}pyridine-2- carboxamide 81, 10 9% HRMS (ESI+) calculated for C23H36FN5O: 417.290389, found 417.291219. HPLC: Rf 3.59 min, 100% purity. 68 N-(Cyclopropylmethyl)-6-{4-[1- (1,1-difluoropropan-2- yl)piperidin-4-yl]-1,4-diazepan- 1-yl}pyridine-2-carboxamide 81, 11 21% HRMS (ESI+) calculated for C23H35F2N5O: 435.280967, found 435.282337. HPLC: Rf 3.99 min, 100% purity. 69 N-(Cyclopropylmethyl)-6-(4-{1- [(2S)-1,1,1-trifluoropropan-2-yl] piperidin-4-yl}-1,4-diazepan-1- yl)pyridine-2-carboxamide 81, 12 5% HRMS (ESI+) calculated for C23H34F3N5O: 453.271545, found 453.273405. HPLC: Rf 5.16 min, 99.2% purity. 70 N-(Cyclopropylmethyl)-6-{4-[1- (4,4,4-trifluorobutan-2-yl) piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-carboxamide 81, 15 9% HRMS (ESI+) calculated for C24H36F3N5O: 467.287195, found 467.288465. HPLC: Rf 4.13 min, 100% purity. 71 N-(Cyclopropylmethyl)-6-{4-[1- (2-methoxyethyl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide 81, 21 17% HRMS (ESI+) calculated for C23H37N5O2: 415.294725, found 415.296525. HPLC: Rf 3.85 min, 100% purity. 72 6-[4-(1-Cyclopentylpiperidin- 4-yl)-1,4-diazepan-1-yl]-N- (cyclopropylmethyl)pyridine- 2-carboxamide 81, 24 6% HRMS (ESI+) calculated for C25H39N5O: 425.315461, found 425.315921. HPLC: Rf 4.07 min, 100% purity. 73 N-(Cyclopropylmethyl)-6-{4- [1-(2-fluorocyclopentyl)piperidin- 4-yl]-1,4-diazepan-1-yl}pyridine- 2-carboxamide 81, 16 4% HRMS (ESI+) calculated for C25H38FN5O: 443.306039, found 443.304639. HPLC: Rf 3.87 min, 100% purity (gradient 20-100%). 74 N-(Cyclopropylmethyl)-6-(4-{1- [(1R)-1-(4-fluorophenyl)ethyl] piperidin-4-yl}-1,4-diazepan-1- yl)pyridine-2-carboxamide 81, 17 5% HRMS (ESI+) calculated for C28H39N5O: 461.315461, found 461.316741. HPLC: Rf 4.03 min, 100% purity (gradient 20-100%). 75 N-(Cyclopropylmethyl)-6-(4-{1- [(1R)-1-(4-fluorophenyl)ethyl] piperidin-4-yl}-1,4-diazepan-1- yl)pyridine-2-carboxamide 81, 18 % HRMS (ESI+) calculated for C28H38FN5O: 479.306039, found 479.306619. HPLC: Rf 3.96 min, 100% purity. 76 N-(Cyclopropylmethyl)-6-(4-{1- [(1R)-2,3-dihydro-1H-inden-1- yl]piperidin-4-yl}-1,4-diazepan- 1-yl)pyridine-2-carboxamide 81, 19 10% HRMS (ESI+) calculated for C29H39N5O: 473.315461, found 473.316401. HPLC: Rf 4.29 min, 99.6% purity. 77 N-(Cyclopropylmethyl)-6-(4-{1- [(1S)-2,3-dihydro-1H-inden-1- yl]piperidin-4-yl}-1,4-diazepan- 1-yl)pyridine-2- carboxamide 81, 20 % HRMS (ESI+) calculated for C29H39N5O: 473.315461, found 473.314341. HPLC: Rf 4.12 min, 100% purity. 78 6-(4-{1-[(2R)-Butan-2-yl] piperidin-4-yl}-1,4-diazepan-1- yl)-N-(pyridine-4-yl)pyridine- 2-carboxamide 83, 8 20% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29509. HPLC: Rf 3.56 min, 100% purity. 79 6-(4-{1-[(2S)-Butan-2-yl] piperidin-4-yl}-1,4-diazepan-1- yl)-N-(pyridine-4-yl)pyridine- 2-carboxamide 83, 9 15% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29628. HPLC: Rf 3.57 min, 100% purity. 80 6-[4-(1-tert-Butylpiperidin-4-yl)- 1,4-diazepan-1-yl]-N-(pyridine-4- yl)pyridine-2-carboxamide 83, * 17% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29503. HPLC: Rf 3.50 min, 100% purity. 81 N-(Pyridin-4-yl)-6-(4-{1-[(2R)- 1,1,1-trifluoropropan-2-yl] piperidin-4-yl}-1,4-diazepan-1- yl)pyridine-2-carboxamide 83, 13 1% HRMS (ESI+) calculated for C24H31F3N6O: 476.251144, found 476.253024. HPLC: Rf 4.15 min, 98.3% purity. 82 N-(Pyridin-4-yl)-6-(4-{1-[(2S)- 1,1,1-trifluoropropan-2-yl] piperidin-4-yl}-1,4-diazepan-1- yl)pyridine-2-carboxamide 83, 12 11% HRMS (ESI+) calculated for C24H31F3N6O: 476.251144, found 476.251594. HPLC: Rf 4.36 min, 100% purity. 83 6-[4-(1-Cyclopentylpiperidin-4- yl)-1,4-diazepan-1-yl]-N- (pyridine-4-yl)pyridine-2- carboxamide 83, 24 2% HRMS (ESI+) calculated for C26H36N6O: 448.29506, found 448.29628. HPLC: Rf 3.61 min, 100% purity. 84 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(2- methylpyridin-4-yl)pyridine- 2-carboxamide 84, 25 31% HRMS (ESI+) calculated for C29H35C1N6O: 518.256087, found 518.257537. HPLC: Rf 3.74 min, 100% purity. 85 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}-1,4- diazepan-1-yl)-N-(2,6- dimethylpyridin-4-yl)pyridine- 2-carboxamide 86, 25 13% HRMS (ESI+) calculated for C30H37C1N6O: 532.271738, found 532.272528. HPLC: Rf 3.81 min, 100% purity. 86 N-(2-Methylpyridin-4-yl)-6-{4- [1-(propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide 84, * 8% HRMS (ESI+) calculated for C25H36N6O: 437.30234, found 437.30215. HPLC: Rf 4.44 min, 100% purity. 87 N-(2,6-Dimethylpyridin-4-yl)-6 {-4-[1-(propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl} pyridine-2-carboxamide 86, * 30% HRMS (ESI+) calculated for C26H38N6O: 451.31799, found 451.31717. HPLC: Rf 4.68 min, 99.8% purity. 88 N-(3-Methylpyridin-4-yl)-6-{4- [1-(Propan-2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl}pyridine-2- carboxamide 85, * 89% HRMS (ESI+) calculated for C25H36N6O: 437.30234, found 437.30194. HPLC: Rf 4.37 min, 100% purity. 89 N-(Pyridin-3-ylmethyl)-6-(4-{1- [(2S)-1,1,1-trifluoropropan-2- yl]piperidin-4-yl}-1,4-diazepan- 1-yl)pyridine-2-carboxamide 87, 12 14% HRMS (ESI+) calculated for C25H33F3N60: 490.266794, found 490.268534. HPLC: Rf 3.98 min, 97.4% purity. 90 N-(Pyridin-3-ylmethyl)-6-{4-[1- (4,4,4-trifluorobutan-2-yl) piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-carboxamide 87, 15 23% HRMS (ESI+) calculated for C26H35F3N6O: 504.282444, found 504.284294. HPLC: Rf 3.39 min, 99.4% purity. 91 N-(Pyridin-3-ylmethyl)-6-{4-[1- (1,1,1-trifluoro-2-methylpropan- 2-yl)piperidin-4-yl]-1,4- diazepan-1-yl}pyridine-2- carboxamide 87, 14 10% HRMS (ESI+) calculated for C26H35F3N6O: 504.282444, found 504.283234. HPLC: Rf 3.88 min, 98.7% purity (gradient 20-100%). 92 6-(4-{1-[(1R)-1-Phenylethyl] piperidin-4-yl}-1,4-diazepan- 1-yl)-N-(pyridine-3-ylmethyl) pyridine-2-carboxamide 87, 17 5% HRMS (ESI+) calculated for C3OH38N6O: 498.31071, found 498.31218. HPLC: Rf 3.34 min, 99.2% purity (gradient 20-100%). 93 N-Butyl-6-(4-{1-[(2S)-1,1,1- trifluoropropan-2-yl]piperidin-4- yl}-1,4-diazepan-1-yl)pyridine- 2-carboxamide 82, 12 46% HRMS (ESI+) calculated for C23H36F3N5O: 455.287195, found 455.288705. HPLC: Rf 5.45 min, 99.1% purity. 94 N-(1,3-Thiazol-2-ylmethyl)-6-(4- {1-[(2S)-1,1,1-trifluoropropan-2- yl]pipendin-4-yl}-1,4-diazepan- 1-yl)pyridine-2-carboxamide 88, 12 9% HRMS (ESI+) calculated for C23H31F3N60S: 496.223215, found 496.225335. HPLC: Rf 4.92 min, 100% purity. 95 1-Methyl-2-(6-{4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-yl)-1H-indole 90, * 8% HRMS (ESI+) calculated for C27H37N5; 432.31217, found 432.31149. HPLC: Rf 5.11 min, 100% purity. 96 1-[1-(Propan-2-yl)piperidin-4-yl]- 4-(6-{1H-pyrrolo[3,2-b]pyridine- 2-yl}pyridine-2-yl)-1,4-diazepane 91, * 8% HRMS (ESI+30) calculated for C25H34N6: 418.284495, found 418.285865. HPLC: Rf 3.60 min, 100% purity. 97 1-[1-(Propan-2-yl)piperidin-4-yl]- 4-(6-{1H-pyrrolo[3,2-c]pyridine- 2-yl}pyridine-2-yl)-1,4-diazepane 92, * 1% HRMS (ESI+) calculated for C25H34N6; 419.29177, found 419.29028. HPLC: Rf 3.64 min, 99.1% purity. 98 1-[1-(Propan-2-yl)piperidin-4-yl]- 4-(6-{1H-pyrrolo[2,3-c]pyridine- 2-yl}pyridine-2-yl)-1,4-diazepane 93, * 1% HRMS (ESI+) calculated for C25H34N6; 419.29177, found 419.29202. HPLC: Rf 3.79 min, 99.2% purity. 99 1-[1-(Propan-2-yl)piperidin-4-yl]- 4-(6-{1H-pyrrolo[2,3-blpyridine-2- yl}pyridine-2-yl)-1,4-diazepane 94, * 9% HRMS (ESI+) calculated for C25H34N6: 418.284495, found 418.286015. HPLC: Rf 3.98 min, 98.8% purity. 100 2-(6-{4-[1-(Propan-2- yl)piperidin-4-yl]-1,4-diazepan- 1-yl}pyridine-2-yl)-1H-indole 95, * 6% HRMS (ESI+) calculated for C26H35N5: 417.289246, found 417.290196. HPLC: Rf 4.93 min, 100% purity. 101 1-[1-(Propan-2-yl)piperidin-4- yl]-4-(6-{1H-pyrrolo[2,3- b]pyridine-3-yl}pyridine-2- yl)-1,4-diazepane 96, * 14% HRMS (ESI+) calculated for C25H34N6: 418.284495, found 418.286275. HPLC: Rf 3.57 min, 99.7% purity. 102 3-(6-14-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}pyridine- 2-yl)-1H-indole 97, * 2% HRMS (ESI+) calculated for C26H35N5: 417.289246, found 417.289786. HPLC: Rf 3.67 min, 100% purity. 103 2-(6-{4-[1-(Propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl}pyridine- 2-yl)-1H-indole-6-carbonitrile 98, * 2% HRMS (ESI+) calculated for C27H34N6; 443.29177, found 443.29233. HPLC: Rf 5.10 min, 98.4% purity. 104 6-Methoxy-2-(6-{4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-yl)-1H-indole 99, * 9% HRMS (ESI+) calculated for C27H37N5O; 448.30709, found 448.30676. HPLC: Rf 5.04 min, 100% purity. 105 5-Methoxy-2-(6-{4[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepan-1- yl}pyridine-2-yl)-1H- indole 100, * 4% HRMS (ESI+) calculated for C27H37N5O: 447.299811, found 447.299691. HPLC: Rf 4.72 min, 100% purity. 106 1-(6-{3H-Imidazo[4,5-clpyridin-2- yl}pyridin-2-yl)-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 102, * 15% LCMS (ES+): 420.0 [MI−11+. HPLC: Rf 3.37 min, 100% purity. 107 1-[6-(4-Methyl-1H-imidazol-2- yl)pyridine-2-yl]-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 101, * 3% HRMS (ESI+) calculated for C22H34N6; 383.29177, found 383.29163. HPLC: Rf 3.36 min, 98.7% purity. 108 1-[6-(4-Ethyl-1H-imidazol-2- yl)pyridine-2-yl]-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 103, * 31% HRMS (ESI+) calculated for C23H36N6: 396.300145, found 396.300705. HPLC: Rf 3.41 min, 99.4% purity. 109 1-[1-(Propan-2-yl)piperidin-4- yl]-4-[6-(4-propyl-1H-imidazol- 2-yl)pyridine-2-yl]-1,4-diazepane 104, * 10% HRMS (ESI+) calculated for C24H38N6; 411.32307, found 411.32318. HPLC: Rf 3.76 min, 99.4% purity. 110 1-{6-[4-(Propan-2-yl)-1H- imidazol-2-yl]pyridine-2- yl}-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 105, * 12% HRMS (ESI+) calculated for C24H38N6; 411.32307, found 411.32324. HPLC: Rf 3.72 min, 98.9% purity. 111 1-[6-[4-Cyclopropyl-1H- imidazol-2-yl)pyridine-2-yl]- 4-[l-(propan-2-yl)piperidin- 4-yl]-1,4-diazepane 106, * 17% HRMS (ESI+) calculated for C24H36N6; 409.30742, found 409.30743. HPLC: Rf 3.61 min, 98.7% purity. 112 1-[1-(Propan-2-yl)piperidin-4- yl]-4-{6-[4-(trifluoromethyl)- 1H-imidazol-2-yl]pyridine-2- yl}-1,4-diazepane 107, * 4% HRMS (ESI+) calculated for C22H31F3N6: 436.25623, found 436.25566. HPLC: Rf 4.32 min, 97.2% purity. 113 1-[6-(4-tert-Butyl-1H-imidazol-2- yl)pyridine-2-yl]-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 108, * 14% HRMS (ESI+) calculated for C25H40N6: 424.331445, found 424.330735. HPLC: Rf 5.28 min, 98.0% purity (gradient 5-50%). 114 1-[6-(4-Phenyl-1H-imidazol-2- yl)pyridine-2-yl]-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 109, * 28% HRMS (ESI+) calculated for C27H36N6: 444.300145, found 444.300585. HPLC: Rf 3.97 min, 98.3% purity. 115 1-[6-(4-Ethyl-1H-imidazol-2- yl)pyridine-2-yl]-4-{1-[(2S)- 1,1,1-trifluoropropan-2- yl]piperidin-4-yl}-1,4-diazepane 103, 12 8% HRMS (ESI+) calculated for C23H33F3N6: 450.27188, found 450.27393. HPLC: Rf 4.42 min, 99.7% purity. 116 1-{1-[(2R)-Butan-2-yl]piperidin- 4-yl}-4-[6-(4-ethyl-1H-imidazol- 2-yl)pyridine-2-yl]-1,4-diazepane 103, 8 22% HRMS (ESI+) calculated for C24H38N6; 411.32307, found 411.32349. HPLC: Rf 3.65 min, 100% purity. 117 1-[6-(4-tert-Butyl-1H-imidazol-2- yl)pyridine-2-yl]-4-(1-tert- butylpiperidin-4-yl)-1,4-diazepane 108, * 22% HRMS (ESI+) calculated for C26H42N6: 438.347095, found 438.348015. HPLC: Rf 3.91 min, 97.1% purity. 118 1-[6-(4.5-Dimethyl-1H-imidazol- 2-yl)pyridine-2-yl]-4-[1- (propan-2-yl)piperidin-4-yl]- 1,4-diazepane 110, * 12% HRMS (ESI+) calculated for C23H36N6; 397.30742, found 397.30603. HPLC: Rf 3.51 min, 100% purity. 119 1-[6-(5-Ethyl-4-methyl-1H- imidazol-2-yl)pyridine-2- yl]-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 111, * 14% HRMS (ESI+) calculated for C24H38N6; 411.32307 found 411.32303. HPLC: Rf 3.69 min, 96.9% purity. 120 1-[6-(4,5-Diethyl-1H-imidazol-2- yl)pyridine-2-yl]-4-[1-(propan-2- yl)piperidin-4-yl]-1,4-diazepane 112, * 6% HRMS (ESI+) calculated for C25H40N6: 425.33872, found 425.3381. HPLC: Rf 3.93 min, 96.8% purity. 121 1-[6-(4-Cyclopropyl-5-methyl- 1H-imidazol-2-yl)pyridine-2- yl]-4-[1-(propan-2-yl)piperidin- 4-yl]-1,4-diazepane 113, * 8% HRMS (ESI+) calculated for C25H38N6: 423.32307, found 423.32352. HPLC: Rf 3.79 min, 98.3% purity. 122 1-[6-(4-Cyclopropyl-5-ethyl-1H- imidazol-2-yl)pyridine-2-yl]-4- [1-(propan-2-yl)piperidin-4-yl]- 1,4-diazepane 114, * 11% HRMS (ESI+) calculated for C26H40N6: 437.33872, found 437.33795. HPLC: Rf 4.00 min, 99.1% purity. 123 1-[6-(5-Methyl-4-propyl-1H- imidazol-2-yl)pyridine-2-yl]-4- [1-(propan-2-yl)piperidin-4- yl]-1,4-diazepane 115, * 9% HRMS (ESI+) calculated for C25H40N6; 425.33872, found 425.33743. HPLC: Rf 3.95 min, 100% purity. 124 1-[6-(4-Ethyl-1-methyl-1H- imidazol-2-yl)pyridine-2-yl]-4- [1-(propan-2-yl)piperidin-4- yl]-1,4-diazepane 117, * 35% HRMS (ESI+) calculated for C24H38N6; 411.32307, found 411.32251. HPLC: Rf 3.47 min, 99.6% purity. * Intermediate commercially available -
- Example 125 was prepared similarly to Example 63, using Intermediate 195 instead of Intermediate 81, to give the title compound (12%) as a yellow gum. HRMS (ESI+) calculated for C24H39N50: 413.315461, found 413.315661. HPLC: Rf 4.01 min, 98.7% purity.
-
- Intermediate 196 (150 mg, 0.82 mmol) and racemic Intermediate 19 (176 mg, 0.82 mmol) were dissolved in DCM (15 mL) and NaBH(OAc)3 (867 mg, 4.09 mmol) was added. The reaction mixture was stirred for 18 h, diluted with DCM (25 mL), washed with sat aq Na2CO3 (30 mL), brine (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified y reverse phase HPLC to give the title compound (64.1 mg, 21%) as a white solid. HRMS (ESI+) calculated for C22H30N4S: 382.219118, found 382.220358. HPLC: Rf 3.45 min, 98.9% purity.
-
- Intermediate 119 (90.0 mg, 0.25 mmol) and methoxyacetone (22.2 mg, 0.25 mmol) were dissolved in DCM (7 mL) and NaBH(OAc)3 (267 mg, 1.25 mmol) was added. The reaction mixture was stirred for 3 d, diluted with DCM (50 mL), washed with sat aq Na2CO3 (30 mL), brine (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC and de-salted (K2CO3 in DCM) to give the title compound (13.4 mg, 12%) as a light yellow gum. HRMS (ESI+) calculated for C24H39N502: 429.310376, found 429.311516. HPLC: Rf 3.94 min, 99.1% purity.
- Examples 128-139 were prepared similarly to Example 127, by reacting Intermediates 119-123 with the appropriate aldehyde or ketone; see Table 18 below.
-
TABLE 18 Reductive alkylations of Intermediates 119-123 SM/ Ex Structure Name Yield HRMS (ESI±), HPLC 128 N-(Cyclopropylmethyl)-6- {4-[1-(oxolan-3-yl)piperidin- 4-yl]-1,4-diazepan-1- yl}pyridine-2-carboxamide Int 119 12% HRMS (EST+) calculated for C24H37N5O2: 427.294725, found 427.295685. HPLC: Rf 3.76 min, 99.1% purity. 129 6-[4-(1-Benzylpiperidin-4- yl)-1,4-diazepan-1-yl]-N- (cyclopropylmethyl) pyridine-2-carboxamide Int 119 23% HRMS (ESI+) calculated for C27H37N5O: 447.299811, found 447.301461. HPLC: Rf 4.23 min, 97.3% purity. 130 N-(Cyclopropylmethyl)-6-(4- {1-[(4-fluorophenyl)methyl] piperidin-4-yl}- 1,4-diazepan-1-yl)pyridine- 2-carboxamide Int 119 25% HRMS (ESI+) calculated for C27H36FN5O: 465.290389, found 465.291239. HPLC: Rf 4.29 min, 96.9% purity. 131 N-(Cyclopropylmethyl)-6-(4- {1-[(2-methylphenyl)methyl] piperidin-4-yl}-1,4-diazepan- 1-yl)pyridine-2-carboxamide Int 119 25% HRMS (EST+) calculated for C28H39N5O: 461.315461, found 461.317091. HPLC: Rf 4.32 min, 98.6% purity. 132 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}- 1,4-diazepan-1-yl)- N-(cyclopropylmethyl) pyridine-2-carboxamide Int 119 59% HRMS (ESI+) calculated for C27H36C1N5O: 481.260839, found 481.262229. HPLC: Rf 5.14 min, 98.4% purity. 133 N-(Cyclopropylmethyl)-6- (4-{1-[(2-methoxyphenyl) methyl]piperidin-4-yl]-1,4- diazepan-1-yl)pyridine-2- carboxamide Int 119 45% HRMS (ESI+) calculated for C28H39N5O2: 477.310376, found 477.311266. HPLC: Rf 4.31 min, 97.8% purity. 134 6-(4-{1-[(3-Chlorophenyl) methyl]piperidin-4-yl]-1,4- diazepan-1-yl)-N- (cyclopropylmethyl) pyridine-2-carboxamide Int 119 34% HRMS (ESI+) calculated for C27H36C1N5O: 481.260839, found 481.262369. HPLC: Rf 4.45 min, 97.6% purity. 135 6-(4-{1-[(2-Chloro-4- fluorophenyl)methyl] piperidin-4-yl]-1,4-diazepan- 1-yl)-N-(cyclopropylmethyl) pyridine-2-carboxamide Int 119 39% HRMS (ESI+) calculated for C27H35C1FN5O: 499.251417, found 499.253217. HPLC: Rf 4.38 min, 97.2% purity. 136 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin- 4-yl}-1,4-diazepan-1- yl)pyridine-2- carboxamide Int 120 20% HRMS (EST+) calculated for C23H30C1N5O: 427.213888, found 427.214648. HPLC: Rf 3.72 min, 100% purity. 137 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}- 1,4-diazepan-1-yl)- N-ethylpyridine-2- carboxamide Int 121 1% HRMS (ESI+) calculated for 5 C25H34C1N5O: 455.245188, found 455.247018. HPLC: Rf 3.99 min, 99.1% purity. 138 N-Butyl-6-(4-{1-[(2- chlorophenyl)methyl] piperidin-4-yl}-1,4- diazepan-1-yl)pyridine-2- carboxamide Int 122 7% HRMS (ESI+) calculated for C27H38C1N5O: 483.276489,10 found 483.277239. HPLC: Rf 4.44 min, 99.8% purity. 139 6-(4-{1-[(2-Chlorophenyl) methyl]piperidin-4-yl}- 1,4-diazepan-1-yl)- N-[3-(1H-imidazol-1- yl)propyl]pyridine-2- carboxamide Int 123 43% HRMS (ESI+) calculated for C29H38C1N7O: 535.282637, found 535.284117. HPLC: Rf15 3.61 min, 97.5% purity. -
- Intermediate 135 (200 mg, 0.58 mmol), EDC.HCl (167 mg, 0.87 mmol), HONB (156 mg, 0.87 mmol), N-methyl-1,2-phenylenediamine (177 mg, 1.45 mmol) and DIPEA (144 mL, 0.87 mmol) were dissolved in DCM (4 mL) and stirred at 45° C. in a sealed tube overnight. The reaction mixture was diluted with DCM (20 mL), washed with sat aq NaHCO3 (25 mL), brine (25 mL) and concentrated in vacuo. The residue was purified by column chromatography, dissolved in acetic acid (2 mL) and heated using a microwave (150° C., absorption high) for 30 min. The solvents were removed in vacuo and the residue dissolved in DCM (25 mL), washed with sat aq NaHCO3 (25 mL), brine (25 mL) and concentrated in vacuo. The product was purified by reverse phase HPLC to give the title compound (44.3 mg, 18%) as a colourless gum. HRMS (ESI+) calculated for C26H36N6; 433.30742, found 433.30667. HPLC: Rf 3.66 min, 100% purity.
- Examples 141-152 were prepared similarly to Example 140, by reacting Intermediate 135 with the appropriate aniline; see Table 19 below.
-
TABLE 19 Amide formation and cyclisation with Intermediate 135 Ex Structure Name Reagent Yield HRMS (ESI+), HPLC 141 2-(6-{4-[1-(Propan-2- yl)piperidin-4-yl]-1,4- diazepan-1-yl} pyridine-2-yl)- 1H-1,3-benzodiazole 24% HRMS (ESI+) calculated for C25H34N6: 418.284495, found 418.286455. HPLC: Rf 4.36 min, 99.6% purity. 142 7-Fluoro-2-(6-{4-[1- (propan-2-yl) piperidin- 4-yl]-1,4-diazepan-1- yl}pyridine-2-yl)- 1H-1,3-benzodiazole 2% HRMS (ESI+) calculated for C25H33FN6; 437.28235, found 437.28098. HPLC: Rf 3.94 min, 100% purity. 143 7-Methyl-2-(6-{4-[1- (propan-2-yl) piperidin- 4-yl]-1,4-diazepan-1- yl}pyridine-2-yl)-1H- 1,3-benzodiazole 7% HRMS (EST+) calculated for C26H36N6; 433.30742, found 433.30569. HPLC: Rf 3.91 min, 100% purity. 144 2-(6-14-[1-(Propan- 2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl} pyridine-2-yl)-6- (trifluoromethyl)-1H- 1,3-benzodiazole 5% HRMS (ESI+) calculated for C26H33F3N6; 487.27916, found 487.27872. HPLC: Rf 4.50 min, 98.3% purity. 145 5,6-Difluoro-2-(6- {4-[1-(propan-2-yl) piperidin- 4-yl]-1,4-diazepan- 1-yl}pyridine-2-yl)- 1H-1,3-benzodiazole 6% HRMS (ESI+) calculated for C25H32F2N6; 455.27293, found 455.27115. HPLC: Rf 4.12 min, 100% purity. 146 5,6-Dimethyl-2-(6- {4-[1-(propan-2-yl) piperidin-4- yl}-1,4-diazepan-1- yl}pyridine-2-yl)- 1H-1,3-benzodiazole 2% HRMS (ESI+) calculated for C27H38N6; 447.32307, found 447.32205. HPLC: Rf 4.17 min, 100% purity. 147 6-Fluoro-2-(6-{4-[1- (propan-2-yl) piperidin- 4-yl]-1,4-diazepan-1- yl}pyridine-2-yl)- 1H-1,3-benzodiazole 4% HRMS (ESI+) calculated for C25H33FN6; 437.28235, found 437.28287. HPLC: Rf 3.86 min, 99.2% purity. 148 6-Methyl-2-(6-{4-[1- (propan-2-yl) piperidin- 4-yl]-1,4-diazepan-1- yl}pyridine-2-yl)- 1H-1,3-benzodiazole 6% HRMS (ESI+) calculated for C26H36N6; 433.30742, 433.3064. HPLC: Rf 3.97 min, 99.4% purity. 149 2-(6-{4-[1- (Propan-2- yl)piperidin-4-yl]- 1,4-diazepan-1-yl} pyridine-2-yl)-1H- 1,3-benzodiazole-6- carbonitrile 7% HRMS (ESI+) calculated for C26H33N7; 444.28702, found 444.2869. HPLC: Rf 4.13 min, 99.1% purity. 150 6-Methoxy-2-(6-{4- [1-(propan-2-yl) piperidin- 4-yl]-1,4-diazepan- 1-yl}pyridine-2- yl)-1H- 1,3-benzodiazole 4% HRMS (ESI+) calculated for C26H36N6O; 449.30234, found 449.30258. HPLC: Rf 3.91 min, 100% purity. 151 2-(6-{4-[1-(Propan- 2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl} pyridine-2-yl)-1,3- benzothiazole 17% HRMS (ESI+) calculated for C25H33N5S: 435.245667, found 435.247347. HPLC: Rf 6.21 min, 98.7% purity. 152 2-(6-{4-[1-(Propan- 2-yl)piperidin-4-yl]- 1,4-diazepan-1-yl} pyridine-2-yl)-1,3- benzoxazole 20% HRMS (ESI+) calculated for C25H33N5O: 419.268511, found 419.269101. HPLC: Rf 4.43 min, 100% purity. -
- Intermediate 137 (125 mg, 0.35 mmol) and DIPEA (108 mg, 0.83 mmol) were dissolved in DCM (10 mL), acetyl chloride (28.6 mg, 0.36 mmol) was added and the reaction mixture was stirred for 16 h. The reaction mixture was partitioned between DCM (75 mL) and sat aq Na2CO3 (25 mL) and the organic fraction was separated and washed with brine (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was suspended in MeCN (2 mL) and xylenes (5 mL) and heated to 150° C. for 3 h. The solvents were removed in vacuo and the residue was purified by reverse phase HPLC to give the title compound (10.0 mg, 11%) as a yellow gum. HRMS (ESI+) calculated for C21H32N60: 384.26376, found 384.26221. HPLC: Rf 3.64 min, 98.5% purity.
-
- Example 154 was prepared similarly to Example 153, using Intermediate 138 instead of Intermediate 137 and butanoyl chloride instead of acetyl chloride, to give the title compound (8%) as a yellow gum. HRMS (ESI+) calculated for C24H38N60; 427.31799, found 427.31772. HPLC: Rf 4.60 min, 100% purity.
- Examples 155-167 were prepared similarly to Example 153, by reacting Intermediate 137 with the appropriate acyl chloride; see Table 20 below.
-
TABLE 20 Synthesis of 1,2,4-oxadiazoles from Intermediate 137 HRMS (ESI+), Ex Structure Name Reagent Yield HPLC 155 1-[6-(5-Ethyl-1,2,4- oxadiazol-3-yl) pyridine-2-yl]-4-[1- (propan-2-yl)piperidin- 4-yl]-1,4-diazepane trihydrochloride 2% HRMS (ESI+) calculated for C22H34N6O: 398.27941, found 398.27911. HPLC: Rf 3.98 min, 98.7% purity. 156 1-[1-(Propan-2-yl) piperidin-4-yl]-4-[6- (5-propyl-1,2,4- oxadiazol-3-yl)pyridine- 2-yl]-1,4-diazepane 10% HRMS (ESI+) calculated for C23H36N6O: 412.29506, found 412.2952. HPLC: Rf 4.22 min, 97.8% purity. 157 1-[6-(5-Butyl-1,2,4- oxadiazol-3- yl)pyridine-2-yl]-4- [1-(propan-2-yl) piperidin-4-yl]-1,4- diazepane 8% HRMS (ESI+) calculated for C24H38N60; 427.31799, found 427.31738. HPLC: Rf 4.80 min, 100% purity. 158 1-{6-[5-(Propan-2-yl)- 1,2,4-oxadiazol-3- yl]pyridine-2-yl]-4-[1- (propan-2-yl)piperidin- 4-yl]-1,4-diazepane 9% HRMS (ESI+) calculated for C23H36N6O; 413.30234, found 413.30133. HPLC: Rf 4.44 min, 99.6% purity. 159 1-[6-(5-tert-Butyl-1,2,4- oxadiazol-3-yl)pyridine- 2-yl]-4-[1-(propan-2- yl)piperidin-4-yl]-1,4- diazepane 11% HRMS (ESI+) calculated for C24H38N60; 427.31799, found 427.31732. HPLC: Rf 4.69 min, 99.3% purity. 160 1-{6-[5-(2,2- Dimethylpropyl)-1,2,4- oxadiazol-3-yl]pyridine- 2-yl}-4-[1-(propan-2- yl)piperidin-4-yl]-1,4- diazepane 7% HRMS (ESI+) calculated for C25H40N60; 441.33364, found 441.33356. HPLC: Rf 4.93 min, 98.4% purity. 161 1-[6-(5-Cyclopropyl- 1,2,4-oxadiazol-3- yl)pyridine-2-yl]-4- [1-(propan-2-yl) piperidin-4-yl]-1,4- diazepane 10% HRMS (ESI+) calculated for C23H34N60: 410.27941, found 410.28114. HPLC: Rf 4.14 min, 100% purity. 162 1-[6-(5-Cyclopentyl- 1,2,4-oxadiazol-3- yl)pyridine-2-yl}-4- [1-(propan-2-yl) piperidin-4-yl]-1,4- diazepane 13% HRMS (ESI+) calculated for C25H38N60; 439.31799, found 439.31766. HPLC: Rf 4.84 min, 100% purity. 163 1-{6-[5-(Methoxy- methyl)-1,2,4- oxadiazol-3-yl] pyridine-2-yl}-4-[1- (propan-2-yl) 9% HRMS (ESI+) calculated for C22H34N602: 414.274324, found 414.275334. piperidin-4-yl]-1,4- HPLC: Rf 3.79 diazepane min, 98.7% purity. 164 1-[6-(5-Phenyl-1,2,4- oxadiazol-3-yl) pyridine-2-yl]-4-[1- (propan-2-yl) piperidin-4-yl]-1,4- diazepane 2% HRMS (ESI+) calculated for C26H34N60: 446.27941, found 446.28124. HPLC: Rf 4.60 min, 97.1% purity. 165 1-[1-(Propan-2-yl) piperidin-4-yl]-4-16- [5-(pyridine-2-yl)- 1,2,4-oxadiazol-3- yl]pyridine-2-yl}- 1,4-diazepane 5% HRMS (ESI+) calculated for C25H33N70: 447.274659, found 447.274189. HPLC: Rf 3.99 tetrahydrochloride min, 98.1% purity. 166N 1_, 1-(Propan-2-yl) piperidin-4-yl]-4-16- [5-(pyridine-3-yl)- 1,2,4-oxadiazol-3- yl]pyridine-2-yl}- 1,4-diazepane 5% HRMS (ESI+) calculated for C25H33N70: 447.274659, found 447.274019. HPLC: Rf 3.90 tetrahydrochloride min, 98.5% purity. 167 1-[1-(Propan-2-yl) piperidin-4-yl]-4-{6- [5-(pyridine-4-yl)- 1,2,4-oxadiazol-3- yl]pyridine-2-yl}- 1,4-diazepane 5% HRMS (ESI+) calculated for C25H33N70: 447.274659, found 447.275379. HPLC: Rf 3.70 tetrahydrochloride min, 99.4% purity. -
- Intermediate 139 (317 mg, 0.86 mmol) was dissolved in DMF (6 mL), NaH (69.0 mg, 60% dispersion in mineral oil, 1.71 mmol) was added and the reaction mixture was stirred for 30 min. The reaction mixture was cooled to 0° C. and a solution of MeI (182 mg, 1.28 mmol) in DMF (1 mL) was added. The reaction mixture was warmed to room temperature overnight and brine (25 mL) was added. The reaction mixture was extracted with EtOAc (3×15 mL) and the combined organic fractions were washed with brine (10 mL), dried (MgSO4) and concentrated in vacuo. The residue was washed with heptane and purified by reverse phase HPLC to give the title compound (14.0 mg, 4%) as yellow solid. HRMS (ESI+) calculated for C20H32N8: 384.274993, found 384.276623. HPLC: Rf 6.20 min, 97.7% purity.
-
- Intermediate 135 (130 mg, 0.36 mmol) was dissolved in DCM (10 mL) and oxalyl chloride (92.0 mg, 0.72 mmol) and DMF (100 μL) were added. The reaction mixture was stirred for 3 h and the solvents were removed in vacuo. The residue and DIPEA (111 mg, 0.86 mmol) were dissolved in DCM (75 mL) and cooled to 0° C. N′-hydroxycyclopropanecarboximidamide (37.0 mg, 0.37 mmol) was added and the reaction mixture was stirred at 0° C. for 1 h and at room temperature for 1 h. The reaction mixture was partitioned between DCM (75 mL) and sat aq Na2CO3 (25 mL) and the organic fraction was washed with brine (25 mL), dried (MgSO4) and concentrated in vacuo.
- The residue was suspended in xylenes (10 mL) and heated to 150° C. for 1 h. The solvents were removed in vacuo and the residue was purified by reverse phase HPLC to give the title compound (5.20 mg, 4%) as a yellow gum. HRMS (ESI+) calculated for C23H34N60: 410.27941, found 410.28058. HPLC: Rf 4.18 min, 98.6% purity.
-
- Example 170 was prepared similarly to Example 169, using N′-hydroxybenzenecarboximidamide instead of N′-hydroxycyclopropanecarboximidamide, to give the title compound (6%) as a yellow gum. HRMS (ESI+) calculated for C26H34N60: 446.27941, found 446.28042. HPLC: Rf 4.73 min, 98.2% purity.
-
- Intermediate 143 (222 mg, 0.50 mmol) was dissolved in MeCN (1.5 mL) and added to a solution of PPh3 (393 mg, 1.50 mmol) and hexachloroethane (355 mg, 1.50 mmol) in MeCN (5 mL). The reaction mixture was stirred for 10 min, Et3N (300 mg, 3.00 mmol) was added and the reaction mixture was heated at 50° C. overnight. A further solution of PPh3 (131 mg, 0.50 mmol) and hexachloroethane (119 mg, 0.50 mmol) in MeCN (1 mL) was added and the reaction mixture was heated at 50° C. overnight. Brine and sat aq NaHCO3were added and the reaction mixture was extracted with EtOAc (3×10 mL and 2×30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (20.0 mg, 9%) as an orange gum. HRMS (ESI+) calculated for C25H39N5O: 425.315461, found 425.316761. HPLC: Rf 4.74 min, 98.8% purity.
-
- Intermediate 146 (249 mg, 0.58 mmol) and POCl3 (7 mL) were heated at 100° C. for 3 h. The solvents were removed in vacuo, sat aq Na2CO3 (13 mL) was added and the reaction mixture was extracted with EtOAc (×3), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (15.0 mg, 6%) as a light yellow gum. HRMS (ESI+) calculated for C23H34N6O: 410.27941, found 410.28076. HPLC: Rf 3.76 min, 98.1% purity.
-
- Intermediate 148 (45.0 mg, 0.11 mmol), hydrazine hydrate (4 mL) and MeOH (few drops) were heated at reflux for 4 h. The solvents were removed in vacuo and the residue was purified by column chromatography and reverse phase HPLC. The residue was dissolved in DCM (10 mL) and HCl (5 mL, 2.0 M in Et2O) and the solvents were removed in vacuo to give the title compound (3.60 mg, 9%) as a light yellow gum. HRMS (ESI+) calculated for C22H34N6; 382.284495, found 382.285835. HPLC: Rf 3.30 min, 100% purity.
- Examples 174-184 were prepared similarly to Example 63, by reductive alkylation; see Table 21 below.
-
TABLE 21 Reductive alkylations of Intermediates 150 and 154-158Ex Structure Name Ints Yield HRMS (ESI+), HPLC 174 N-(Cyclopropylmethyl)- 6-{7-methyl-4-[1- (propan-2-yl)piperidin- 4-yl]-1,4- diazepan-1-yl}pyridine- 2- carboxamide 150* 8% HRMS (ESI+) calculated for C24H39N5O: 413.315461, found 413.315301. HPLC: Rf 3.84 min, 97.7% purity. 175 6-{7,7-Dihydrogenio- 4-[1-(propan-2-yl) piperdin-4-yl]-1,4- diazepan-1-yl}-N- (pyridine-4-yl)pyridine- 2-carboxamide 157, * 19% HRMS (ESI+) calculated for C24H32[2H]2N6O: 424.29506, found 424.29478. HPLC: Rf 3.45 min, 100% purity. 176 6-(4-{1-[(2R)-Butan-2- yl]piperidin-4-yl}-7,7- dihydrogenio-1,4- diazepan- 1-yl)-N-(pyridine-4-yl) pyridine-2-carboxamide 157, 8 11% HRMS (ESI+) calculated for C25H34[2H]2N6O: 438.31071, found 438.31087. HPLC: Rf 3.56 min, 99.6% purity. 177 6-(4-{1-[(2S)-Butan-2- yl]piperidin-4-yl}- 7,7-dihydrogenio-1,4- diazepan-1-yl)-N- (pyridine-4-yl) pyridine-2-carboxamide 157, 9 8% HRMS (ESI+) calculated for C25H34[2H]2N6O: 438.31071, found 438.3108. HPLC: Rf 3.56 min, 99.3% purity. 178 6-(7,7-Dihydrogenio-4- {1-[(2S)-1,1,1- trifluoropropan-2-yl] piperidin-4-yl}-1,4- diazepan-1-yl)-N- (pyridine-4-yl)pyridine- 2-carboxamide 157, 12 10% HRMS (ESI+) calculated for C24H29[2H]2F3N6O: 478.266794, found 478.264914. HPLC: Rf 4.35 min, 98.6% purity. 179 6-[4-(1-Cyclopentyl- piperidin-4-yl)-7,7- dihydrogenio-1,4- diazepan-1-yl]-N- (pyridine-4-yl)pyridine- 2-carboxamide 157, 24 1% HRMS (ESI+) calculated for C26H34[2H]2N6O: 450.31071, found 450.30879. HPLC: Rf 3.63 min, 99.3% purity. 180 6-(4-{1-[(2- Chlorophenyl)methyl] piperidin-4-yl}-7,7- dihydrogenio-1,4- diazepan-1-yl)-N- (pyridin-4-yl)pyridine- 2-carboxamide 157, 25 39% HRMS (ESI+) calculated for C28H31[2H]2C1N6O: 506.256087, found 506.256737. HPLC: Rf 3.84 min, 99.6% purity. 181 N-(Cyclopropylmethyl)- 6-{7,7-dihydrogenio- 4-[1-(propan-2-yl) piperidin- 4-yl]-1,4-diazepan-1- yl}pyridine-2- carboxamide 158, * 9% LCMS (ES+): 402.4 [MH+]. HPLC: Rf 4.79 min, 99.6% purity. 182 6-{6-Methyl-4-[1- (propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1- yl}-N-(pyridin-4- yl)pyridine-2- carboxamide 154, * 46% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29564. HPLC: Rf 3.53 min, 99.6% purity. 183 N-(Cyclopropylmethyl)- 6-{6-hydroxy-4-[1- (propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl} pyridine-2-carboxamide 155, * 14% HRMS (ESI+) calculated for C23H37N5O2: 415.294726, found 415.296206. HPLC: Rf 3.62 min, 100% purity. 184 N-(Cyclopropylmethyl)- 6-{5-methyl-4-[1- (propan-2-yl)piperidin- 4-yl]-1,4-diazepan-1-yl} pyridine-2-carboxamide 156, * 17% HRMS (ESI+) calculated for C24H39N5O: 413.315461, found 413.315271. HPLC: Rf 3.85 min, 98.5% purity. * Commercialy available -
- Intermediate 43 (224 mg, 0.90 mmol) was dissolved in dioxane (3 mL) and NaOtBu (111 mg, 1.15 mmol), Pd2(dba)3 (30.1 mg, 0.03 mmol), Xantphos (53.7 mg, 0.07 mmol) and Intermediate 183 (200 mg, 0.82 mmol) were added. The reaction mixture was heated at 100° C. for 3 d. The solvents were removed in vacuo and the residue was dissolved in DCM, filtered and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (5.61 mg, 1%) as a light yellow solid. HRMS (ESI+) calculated for C25H35FN60: 454.285638, found 454.287278. HPLC: Rf 3.07 min, 99.7% purity.
-
- Intermediate 173 (150 mg, 0.54 mmol), Intermediate 159 (123 mg, 0.54 mmol), BINAP (33.6 mg, 0.05 mmol), palladium acetate (8.50 mg, 0.04 mmol) and Cs2CO3 (264 mg, 0.81 mmol) were dissolved in dioxane (2 mL) and heated at 100° C. for 4 d. The reaction mixture was filtered and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (14.1 mg, 6%) as a light yellow gum. HRMS (ESI+) calculated for C24H32[2H]2N6O: 424.29506, found 424.29411. HPLC: Rf 3.43 min, 98.5% purity.
- Examples 187-202 were prepared similarly to Example 186, by Buchwald-Hartwig reactions with Intermediates 173 and 174; see Table 22 below.
-
TABLE 22 Buchwald-Hartwig reactions of Intermediates 173 and 174 Ex Structure Name Ints Yield HRMS (ESI±), HPLC 187 6-{4-[3-Fluoro-1-(propan- 2-yl)piperidin-4-yl}-5,5- dihydrogenio- 1,4-diazepan-1-yl}-N- (pyridin-4-yl) pyridine-2-carboxamide 173, 182 6% HRMS (ESI+) calculated for C24H31[2H]2FN6O: 442.285638, found 442.283958. HPLC: Rf 3.42 min, 98.2% purity. 188 6-(4-{1-[(2R)-Butan-2-yl] piperidin-4-yl}-5,5- dihydrogenio-1,4- diazepan-1-yl)-N- (pyridin-4- yl)pyridine-2-carboxamide 173, 164 16% HRMS (ESI+) calculated for C25H34[2H]2N6O: 438.31071, found 438.31053. HPLC: Rf 3.54 min, 99.6% purity. 189 6-(4-{1-[(2S)-Butan-2-yl] piperidin-4-yl}-5,5- dihydrogenio-1,4- diazepan-1-yl)-N- (pyridin-4-yl) pyridine-2-carboxamide 173, 165 6% HRMS (ESI+) calculated for C25H34[2H]2N6O: 438.31071, found 438.3094. HPLC: Rf 3.54 min, 100% purity. 190 6-(5,5-Dihydrogenio-4- {1-[(2S)-1,1,1- trifluoropropan-2-yl] piperidin-4-yl}-1,4- diazepan-1-yl)-N- (pyridin-4-yl)pyridine- 2-carboxamide 173, 166 16% HRMS (ESI+) calculated for C24H29[2H]2F3N6O: 478.266794, found 478.264634. HPLC: Rf 4.35 min, 100% purity. 191 6-[4-(1-Cyclopentyl- piperidin-4-yl)-5,5- dihydrogenio-1,4- diazepan-1-yl]-N- (pyridin-4-yl)pyridine-2- carboxamide 173, 167 2% HRMS (ESI+) calculated for C26H34[2H]2N6O: 450.31071, found 450.31108. HPLC: Rf 3.60 min, 100% purity. 192 N-(Cyclopropylmethyl)-6- {5,5-dihydrogenio-4-[1- (propan-2-yl)piperidin-4- yl]-1,4-diazepan-1- yl}pyridine-2- carboxamide 174, 159 1% LCMS (ES+): 402.5 [MH]+. HPLC: Rf 3.75 min, 99.5% purity. 193 6-{3-Methyl-4-[1-(propan- 2-yl)piperidin-4-yl]-1,4- diazepan-1-yl}-N- (pyridin-4-yl)pyridine-2- carboxamide 173, 168 6% HRMS (ESI+) calculated for C25H36N6O: 436.29506, found 436.29695. HPLC: Rf 3.54 min, 100% purity. 194 N-(Cyclopropylmethyl)-6- {3-methyl-4-[1-(propan-2- yl)piperidin-4-yl]-1,4- diazepan-1-yl}pyridine-2- carboxamide 174, 168 3% HRMS (ESI+) calculated for C24H39N5O: 413.315461, found 413.316781. HPLC: Rf 4.05 min, 100% purity. 195 6-{5,5-Dihydrogenio-3- methyl-4-[1-(propan-2- yl)piperidin-4-yl]-1,4- diazepan-1-yl}-N-(pyridin- 4-yl)pyridine- 2-carboxamide 173, 169 10% HRMS (ESI+) calculated for C25H34[2H]2N6O: 438.31071, found 438.30995. HPLC: Rf 3.53 min, 98.9% 196 6-(5,5-Dihydrogenio-3- methyl-4-{1-[(2S)-1,1,1- trifluoropropan-2- yl]piperidin-4-yl}-1,4- diazepan-1-yl)-N- (pyridin-4-yl)pyridine- 2-carboxamide 173, 170 1% HRMS (ESI+) calculated for C25H31[2H]2F3N6O: 492.282444, found 492.281754. HPLC: Rf 4.41 min, 96.2% purity. 197 6-{6-[1-(Propan-2-yl) piperidin-4-yl]-3,6- diazabicyclo[3.2.2] nonan-3-yl}-N- (pyridin-4-yl)pyridine- 2-carboxamide 173, 172 7% HRMS (ESI+) calculated for C26H36N60: 448.29506, found 448.29647. HPLC: Rf 3.62 min, 100% purity. 198 6-{6-[3-Fluoro-1-(propan- 2-yl)piperidin-4-yl]-3,6- diazabicyclo[3.2.2]nonan- 3-yl}-N-(pyridin-4-yl) pyridine-2-carboxamide 173, 188 1% HRMS (ESI+) calculated for C26H35FN6O: 466.285638, found 466.287348. HPLC: Rf 3.50 min, 99.7% purity. 199 N-(Cyclopropylmethyl)-6- {6-[1-(propan-2-yl) piperidin-4-yl]-3,6- diazabicyclo[3.2.2]nonan- 3-yl}pyridine-2- carboxamide trihydrochloride 174, 172 15% HRMS (ESI+) calculated for C25H39N5O: 425.315461, found 425.314961. HPLC: Rf 3.85 min, 97.5% purity. 200 N-(Cyclopropylmethyl)-6- {3-[1-(propan-2-yl) piperidin-4-yl]-3,6- diazabicyclo[3.2.1]octan-6- yl}pyridine-2-carboxamide 174 32% HRMS (ESI+) calculated for C24H37N5O: 411.299811, found 411.298381. HPLC: Rf 3.64 min, 99.2% purity. 201 6-(4-{2-[4-(Propan-2-yl] morpholin-3-yl]ethyl}-1,4- diazepan-1-yl)-N-(pyridin- 4-yl)pyridine-2- carboxamide 173, 243 15% HRMS (ESI+) calculated for C25H36N6O2: 452.289974, found 452.291804. HPLC: Rf 3.50 min, 99.3% purity. 202 6-(4-{[(2R)-1-Methyl-4- (propan-2-yl)piperazin- 2-yl]methyl}-1,4-diazepan- 1-yl)-N-(pyridin-4-yl) pyridine-2-carboxamide 173, 249 2% HRMS (ESI+) calculated for C25H37N7O: 451.305959, found 451.307619. HPLC: Rf 3.59 min, 99.5% purity. -
- Intermediate 175 (200 mg, 0.52 mmol) was dissolved in DCM (30 mL) and 2-chloro-4-fluorobenzaldehyde (166 mg, 1.05 mmol) and NaBH(OAc)3 (554 mg, 2.61 mmol) were added. The reaction mixture was stirred for 18 h, diluted with DCM (30 mL), washed with sat aq Na2CO3 (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (69.7 mg, 25%) as a pale yellow solid. HRMS (ESI+) calculated for C28H30[2H]2C1FN6O: 524.246666, found 524.245956. HPLC: Rf 3.93 min, 99.3% purity.
- Examples 204-209 were prepared similarly to Example 203, by reacting Intermediates 175, 185, 191 and 273 with the appropriate aldehyde; see Table 23 below.
-
TABLE 23 Reductive alkylation reactions with Intermediates 175, 185, 191 and 273 Ex Structure Name Int Yield HRMS (ESI*), HPLC 204 6-(4-{1-[(2- Chlorophenyl)methyl] piperidin-4-yl}-5,5- dihydrogenio-1,4- diazepan-1-yl)-N- (pyridin-4-yl)pyridine- 2-carboxamide 175 18% HRMS (ESI+) calculated for C28H31[2H]2C1N6O: 506.256087, found 506.256187. HPLC: Rf 3.86 min, 98.9% purity. 205 6-(4-{1-[(2-Chloro-4- fluorophenyl)methyl] piperidin-4-yl}-7,7- dihydrogenio-1,4- diazepan-1-yl)-N- (pyridin-4-yl)pyridine- 2-carboxamide 273 17% HRMS (ESI+) calculated for C28H30[2H]2C1FN6O: 524.246666, found 524.246206. HPLC: Rf 3.95 min, 99.5% purity. 206 6-(4-{1-[(2- Chlorophenyl)methyl] piperidin-4-yl]-5,5- dihydrogenio-3-methyl- 1,4-diazepan-1-yl)-N- (pyridin-4-yl)pyridine- 2-carboxamide 185 27% HRMS (ESI+) calculated for C29H33[2H]2C1N60: 520.271738, found 520.271778. HPLC: Rf 3.94 min, 100% purity. 207 6-(4-{1-[(2-Chloro-4- fluorophenyl)methyl] piperidin-4-yl]-5,5- dihydrogenio-3-methyl- 1,4-diazepan-1-yl)-N- (pyridin-4-yl)pyridine- 2-carboxamide 185 8% HRMS (ESI+) calculated for C29H32[2H]2C1FN6O: 538.262316, found 538.261216. HPLC: Rf 4.01 min, 99.1% purity. 208 6-(6-{1-[(2- Chlorophenyl)methyl] piperidin-4-yl}-3,6- diazabicyclo[3.2.2] nonan-3-yl)-N-(pyridin- 4-yl)pyridine-2- carboxamide 191 6% HRMS (ESI+) calculated for C30H35C1N6O: 530.256087, found 530.256037. HPLC: Rf 3.98 min, 99.8% purity. 209 6-(6-{1-[(2-Chloro-4- fluorophenyl)methyl] piperidin-4-yl}-3,6- diazabicyclo[3.2.2] nonan-3-yl)-N- (pyridin-4-yl) pyridine-2-carboxamide 191 7% HRMS (ESI+) calculated for C30H34C1FN6O: 548.246666, found 548.246636. HPLC: Rf 4.07 min, 100% purity. -
- Example 210 was prepared similarly to Example 203, using Intermediate 125 instead of Intermediate 175 and acetone instead of 2-chloro-4-fluorobenzaldehyde, to give the title compound (22%) as a colourless gum. HRMS (ESI+) calculated for C24H33FN6O: 440.269988, found 440.271298. HPLC: Rf 3.40 min, 100% purity.
- Examples 211-214 were prepared similarly to Example 210, by reacting Intermediates 126, 176 and 177 with the appropriate ketone; see Table 24 below.
-
TABLE 24 Reductive alkylation reactions with Intermediates 126, 176 and 177 Ex Structure Name Ints Yield HRMS (ESI±), HPLC 211 6-{4-[3-Fluoro-1-(propan- 2-yl)piperidin-4-yl]-7,7- dihydrogenio-1,4-diazepan- 1-yl}-N-(pyridin-4-yl) pyridine-2-carboxamide 176 21% HRMS (ESI+) calculated for C24H31[2H]2FN6O: 442.285638, found 442.284838. HPLC: Rf 3.86 min, 98.2% purity. 212 1-[6-(4-Cyclopropyl-1H- imidazol-2-yl)pyridin-2- yl]-4-[3-fluoro-1-(propan- 2-yl)piperidin-4-yl]- 1,4-diazepane 126 30% HRMS (ESI+) calculated for C24H35FN6: 427.298, found 427.29803. HPLC: Rf 3.58 min, 99.1% purity. 213 1-[6-(4-Cyclopropyl-5- methyl-1H-imidazol-2-yl) pyridin-2-yl]-4-[3-fluoro- 1-(propan-2-yl)piperidin- 4-yl]-1,4-diazepane 177 15% HRMS (ESI+) calculated for C25H37FN6: 441.31365, found 441.3136. HPLC: Rf 3.71 min, 98.4% purity. 214 1-(1-Cyclopentyl-3- fluoropiperidin-4-yl)- 4-[6-(4-cyclopropyl-5- methyl-1H-imidazol- 2-yl)pyridin-2-yl]-1,4- diazepane 177 8% HRMS (ESI+) calculated for C27H39FN6: 467.3293, found 467.3287. HPLC: Rf 3.81 min, 99.3% purity. -
- Example 215 was prepared similarly to Example 203, using Intermediate 127 instead of Intermediate 175 and acetone instead of 2-chloro-4-fluorobenzaldehyde, to give the title compound (1%) as a white solid. HRMS (ESI+) calculated for C26H38N6O: 450.31071, found 450.31244. HPLC: Rf 3.24 min, 100% purity.
-
- Example 216 was prepared similarly to Example 203, using Intermediate 128 instead of Intermediate 175 and acetone instead of 2-chloro-4-fluorobenzaldehyde, to give the title compound (14%) as a white solid. HRMS (ESI+) calculated for C23H37N5O2: 415.294726, found 415.295486. HPLC: Rf 3.58 min, 100% purity.
-
- Example 217 was prepared similarly to Example 63, using Intermediate 192 instead of Intermediate 81, to give the title compound (11%) as a colourless gum. HRMS (ESI+) calculated for C26H41N5O: 439.331111, found 439.333241. HPLC: Rf 4.18 min, 98.9% purity.
-
- Example 218 was prepared similarly to Example 217, using Intermediate 193 instead of Intermediate 192 and Intermediate 25 instead of 1-(propan-2-yl)piperidin-4-one, to give the title compound (23%) as a yellow solid. HRMS (ESI+) calculated for C31H37C1N6O: 544.271738, found 544.271478. HPLC: Rf 4.08 min, 99.4% purity.
-
- Intermediate 184 (100 mg, 0.26 mmol) was dissolved in THF (3 mL) and propylmagnesium bromide (1.28 mL, 2 M in Et2O, 2.57 mmol) was added. The reaction mixture was stirred for 18 h and concentrated in vacuo. The residue was dissolved in DCM (20 mL), washed with sat aq Na2CO3 (15 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (20.2 mg, 21%) as a yellow gum. HRMS (ESI+) calculated for C22H36N4O: 372.288912, found 372.290132. HPLC: Rf 4.18 min, 99.2% purity.
-
- Intermediate 184 (342 mg, 0.88 mmol) was dissolved in THF (8 mL) and benzylmagnesium chloride (8.78 mL, 1 M in Et2O, 8.78 mmol) was added. The reaction mixture was stirred for 18 h and the solvents were removed in vacuo. The residue was dissolved in DCM (20 mL), washed with sat aq Na2CO3 (15 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (2.83 mg, 1%) as a yellow gum. HRMS (ESI+) calculated for C26H36N40: 420.288912, found 420.290762. HPLC: Rf 4.50 min, 99.6% purity.
-
- Intermediate 200 (102 mg, 0.26 mmol) was dissolved in DCM (3 mL) and acetone (19.0 μL, 0.26 mmol) and NaBH(OAc)3 (273 mg, 1.29 mmol) were added. The reaction mixture was stirred for 2 d, diluted with DCM (30 mL) and quenched with sat aq Na2CO3 (20 mL). The aq fraction was extracted with DCM (2×15 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (0.86 mg, 1%) as a colourless gum. HRMS (ESI+) calculated for C25H35N5O2: 437.279075, found 437.279315. HPLC: Rf 3.45 min, 95.6% purity.
-
- Intermediate 201 (54.0 mg, 0.14 mmol) was dissolved in DCM (4 mL) and TFA (1 mL) was added. The reaction mixture was stirred for 2 h. The solvents were removed in vacuo and the residue partitioned between DCM (20 mL) and 1 M aq NaOH (20 mL). The aq fraction was basified to pH 14 with NaOH and extracted with DCM (3×50 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM (5 mL) and 1-(propan-2-yl)piperidin-4-one (40.0 μL, 0.27 mmol) and NaBH(OAc)3 (57.0 mg, 0.30 mmol) were added. The reaction mixture was stirred for 4 d. Further 1-(propan-2-yl)piperidin-4-one (40.0 μL, 0.27 mmol) and NaBH(OAc)3 (57.0 mg, 0.30 mmol) were added. The reaction mixture was stirred for 1 d. The reaction mixture was diluted with DCM (10 mL) and quenched with water (5 mL). The organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (2.33 mg, 4%) as a white gum. LCMS (ES+): 423.2 [MH]+. HPLC: Rf 3.49 min, 99.2% purity.
-
- Intermediate 206 (75.0 mg, 0.18 mmol) was dissolved in THF (5 mL), the reaction mixture was cooled to 0° C. and LiAlH4 (0.71 mL, 2.4 M in THF, 1.77 mmol) was added. The reaction mixture was heated at reflux for 5 h and cooled to 0° C. The reaction mixture was diluted with Et2O (20 mL) and quenched with water (0.40 mL) and 1 M aq NaOH (0.20 mL). MgSO4 was added and the reaction was stirred for 15 min, filtered and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (8.39 mg, 12%) as a beige solid. HRMS (ESI+) calculated for C24H36N6: 409.30742, found 409.30701. HPLC: Rf 3.61 min, 99.4% purity.
-
- Example 224 was prepared similarly to Example 223, using Intermediate 210 instead of Intermediate 206, to give the title compound (22.1 mg, 44%) as a white solid. HRMS (ESI+) calculated for C26H38N6: 435.32307, found 435.32275. HPLC: Rf 3.58 min, 98.4% purity.
-
- Example 225 was prepared similarly to Example 223, using Intermediate 211 instead of Intermediate 206, to give the title compound (30.3 mg, 46%) as a white solid. HRMS (ESI+) calculated for C26H38N6: 435.32307, found 435.32291. HPLC: Rf 3.57 min, 98.4% purity.
-
- Intermediate 213 (300 mg, 0.82 mmol) was dissolved in DCM (10.0 mL), cyclopentanone (72.3 mg, 0.86 mmol) and NaBH(OAc)3 (347 mg, 1.64 mmol) were added and the reaction mixture was stirred overnight. The reaction mixture was diluted with DCM (10 mL) and quenched with water (5 mL). The organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound as a white solid (98.9 mg, 28%). HRMS (ESI+) calculated for C25H34N6O: 435.28669, found 435.28659. HPLC: Rf 3.26 min, 100% purity.
-
- Example 227 was prepared similarly to Example 226, using Intermediate 214 instead of Intermediate 213, to give the title compound (6%) as a light yellow solid. HRMS (ESI+) calculated for C25H34N6O: 435.28669, found 435.28711. HPLC: Rf 3.27 min, 100% purity.
-
- Intermediate 215 was dissolved in DCM (10 mL) and cyclopentanone (170 mg, 2.02 mmol) and NaBH(OAc)3 (779 mg, 3.68 mmol) were added. The reaction mixture was stirred overnight, diluted with DCM (25 mL) and quenched with water (10 mL). The organic fraction was washed with sat aq Na2CO3 (510 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (10.9 mg, 1%) as a white solid. HRMS (ESI+) calculated for C26H36N6O: 449.30234, found 449.30127. HPLC: Rf 3.25 min, 99.8% purity.
-
- Intermediate 225 (150 mg, 0.37 mmol) was dissolved in THF (5 mL) at 0° C. and LiAlH4 (1.00 mL, 2.4 M in THF, 2.40 mmol) was added dropwise. The reaction mixture was heated at 67° C. for 18 h. The reaction mixture was cooled to −5° C. and quenched with water (98 μL), 15% aq NaOH (98 μL) and water (300 μL). The residue was extracted with EtOAc (7×10 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC and column chromatography to give the title compound (4.07 mg, 3%) as a light yellow gum. LCMS (ES+): 395.2 [MH]+. HPLC: Rf 3.70 min, 99.6% purity.
-
- Intermediate 228 (226 mg, 0.53 mmol) was dissolved in DCM (4 mL), TFA (1 mL) was added and the reaction mixture was stirred for 3 h. The solvents were removed in vacuo and the residue was de-salted using a MP-TsOH SPE cartridge, eluting with 7 N ammonia in MeOH. Half of the residue was dissolved in DCM (5 mL) and cyclopentanone (19.8 μL, 0.22 mmol) and NaBH(OAc)3 (85.7 mg, 0.40 mmol) were added. The reaction mixture was stirred overnight, diluted with DCM (10 mL) and quenched with water (5 mL). The organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the crude title compound (13.2 mg, 17%) as a white solid HRMS (ESI+) calculated for C23H34N6: 395.29177, found 395.29117. HPLC: Rf 3.63 min, 98.2% purity.
-
- Example 231 was prepared similarly to Example 230, using Intermediate 229 instead of Intermediate 228, to give the title compound (22%) as a white solid. HRMS (ESI+) calculated for C24H36N6: 409.30742, found 409.30695. HPLC: Rf 3.81 min, 96.7% purity.
-
- Example 232 was prepared similarly to Example 231, using Intermediate 230 instead of Intermediate 229, to give the title compound (11%) as a white solid. HRMS (ESI+) calculated for C24H36N6: 409.30742, found 409.30737. HPLC: Rf 3.78 min, 98.4% purity.
-
- Example 233 was prepared similarly to Example 230, using Intermediate 231 instead of Intermediate 228, to give the title compound (11%) as an off-white solid. HRMS (ESI+) calculated for C22H32N6: 381.27612, found 381.27554. HPLC: Rf 3.74 min, 98.5% purity.
-
- Example 234 was prepared similarly to Example 230, using Intermediate 232 instead of Intermediate 228 and acetone instead of cyclopentanone, to give the title compound (18%) as a colourless gum. HRMS (ESI+) calculated for C22H32N6O: 396.26376, found 396.26423. HPLC: Rf 3.35 min, 95.1% purity.
-
- Intermediate 217 (168 mg, 0.73 mmol) was dissolved in DCM (3 mL) and (R)-1-sec-butyl-piperidin-4-one (169 mg, 1.09 mmol) and NaBH(OAc)3 (308 mg, 1.45 mmol) were added. The reaction mixture was stirred overnight, diluted with DCM (10 mL) and quenched with water (5 mL). The organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (66.7 mg, 25%) as a white solid. HRMS (ESI+) calculated for C21H34N6: 371.29177, found 371.29163. HPLC: Rf 3.52 min, 99.5% purity.
-
- Example 236 was prepared similarly to Example 235, using Intermediate 218 instead of Intermediate 217 and 1-(propan-2-yl)piperidin-4-one instead of (R)-1-sec-butyl-piperidin-4-one, to give the title compound (9%) as a white solid. HRMS (ESI+) calculated for C22H34N6: 383.29177, found 383.29147. HPLC: Rf 3.60 min, 97.2% purity.
-
- Example 237 was prepared similarly to Example 229, using Intermediate 235 instead of Intermediate 225, to give the title compound (17%) as a pale yellow gum. HRMS (ESI+) calculated for C21H32N6: 369.27612, found 369.27597. HPLC: Rf 3.62 min, 99.3% purity.
-
- Intermediate 220 (163 mg, 0.64 mmol) was dissolved in DCM (10 mL) and Intermediate 236 (299 mg, 1.93 mmol) and NaBH(OAc)3 (880 mg, 3.21 mmol) were added. The reaction mixture was stirred for 3 d, diluted with DCM (20 mL) and quenched with sat aq Na2CO3 (20 mL). The aq fraction was extracted with DCM (2×15 mL) and the combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (2.49 mg, 1%) as a colourless gum. HRMS (ESI+) calculated for C24H36N6O: 424.29506, found 424.29622. HPLC: Rf 3.43 min, 100% purity.
-
- Example 239 was prepared similarly to Example 238, using Intermediate 221 instead of Intermediate 220 and 1-(propan-2-yl)piperidin-4-one instead of Intermediate 236, to give the title compound (1%) as a yellow solid. HRMS (ESI+) calculated for C22H32N6O: 396.26376, found 396.26402. HPLC: Rf 3.38 min, 98.3% purity.
-
- Intermediate 238 (250 mg, 0.30 mmol) was dissolved in MeCN (20 mL) and K2CO3 (220 mg, 1.58 mmol) and 2-methylbenzyl bromide (50.0 mg, 0.29 mmol) were added. The reaction mixture was heated at 50° C. for 3 h and the solvents were removed in vacuo. The residue was partitioned between DCM (100 mL) and water (50 mL), the organic fraction was washed with brine (50 mL), dried (MgSO4) and the solvents were removed in vacuo. The residue was purified by reverse phase HPLC to give the title compound (0.050 g, 38%) as a light yellow gum. HRMS (ESI+) calculated for C29H36N6O: 484.29506, found 484.29613. HPLC: Rf 3.86 min, 98.9% purity.
-
- Intermediate 238 (50.0 mg, 0.53 mmol) was dissolved in DCM (20 mL) and 2-chloro-4-fluorobenzaldehyde (170 mg, 1.05 mmol) and NaBH(OAc)3 (0.56 g, 2.63 mmol) were added. The reaction mixture was stirred for 96 h, diluted with DCM (50 mL), washed with sat aq Na2CO3 (75 mL), brine (50 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (0.060 g, 23%) as a yellow gum. HRMS (ESI+) calculated for C28H32C1FN6O: 522.231016, found 522.233146. HPLC: Rf 3.91 min, 100% purity.
-
- Intermediate 237 (71.0 mg, 0.15 mmol) was dissolved in DCM (10 mL), TFA (1 mL) was added and the reaction mixture was stirred for 18 h. The solvents were removed in vacuo, the residue was dissolved in DCM (10 mL), and acetone (17.2 mg, 0.30 mmol) and NaBH(OAc)3 (157 mg, 0.74 mmol) were added. The reaction mixture was stirred for 7 h, diluted with DCM (20 mL), washed with sat aq Na2CO3 (25 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (12.4 mg, 20%) as a light yellow gum. HRMS (ESI+) calculated for C24H34N6O: 422.27941, found 422.28141. HPLC: Rf 3.35 min, 97.4% purity.
-
- Example 243 was prepared similarly to Example 242, using Intermediate 240 instead of Intermediate 237, to give the title compound (49%) as a white solid. HRMS (ESI+) calculated for C25H38N6: 423.32307, found 423.32147. HPLC: Rf 3.67 min, 99.6% purity.
-
- Example 244 was prepared similarly to Example 242, using Intermediate 252 instead of Intermediate 237, to give the title compound (15%) as a white solid. HRMS (ESI+) calculated for C24H34N6O2: 438.274324, found 438.275684. HPLC: Rf 3.51 min, 99.1% purity.
-
- Example 245 was prepared similarly to Example 243, using cyclopentanone instead of acetone, to give the title compound (28%) as a white solid. HRMS (ESI+) calculated for C27H40N6: 449.33872, found 449.33856. HPLC: Rf 3.80 min, 99.4% purity.
-
- Example 246 was prepared similarly to Example 245, using Intermediate 233 instead of Intermediate 240, to give the title compound (12%) as a white solid. HRMS (ESI+) calculated for C25H38N6: 423.32307, found 423.32214. HPLC: Rf 3.78 min, 98.1% purity.
-
- Example 247 was prepared similarly to Example 223, using Intermediate 227 instead of Intermediate 206, to give the title compound (8.77 mg, 8%) as a white solid. HRMS (ESI+) calculated for C24H36N6: 409.30742, found 409.30582. HPLC: Rf 3.50 min, 98.2% purity.
-
- Intermediate 203 (427 mg, 1.38 mmol) and 2-chlorobenzaldehyde (193 mg, 1.38 mmol) were dissolved in DCM (10 mL) and NaBH(OAc)3 (1.46 g, 6.88 mmol) was added. The reaction mixture was stirred for 16 h and quenched with sat aq Na2CO3 (5 mL). The reaction mixture was diluted with a DCM (20 mL), washed with sat aq Na2CO3 solution (3×15 mL), brine (15 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (22.9 mg, 4%) as a light yellow gum. HRMS (ESI+) calculated for C22H27C1N4O; 399.19462, found 399.19543. PLC: Rf 5.16 min, 100% purity.
-
- Intermediate 274 (254 mg, 0.64 mmol) was dissolved in DCM (8 mL), TFA (2 mL) was added and the reaction mixture was stirred overnight. The solvents were removed in vacuo and the residue partitioned between DCM (20 mL) and 1M aq NaOH (10 mL). The aq fraction was basified to pH 14 with NaOH and extracted with DCM (3×50 mL). The combined organic fractions were dried (MgSO4) and the solvents were removed in vacuo. The residue was dissolved in DCM (6 mL) and 1-(propan-2-yl)piperidin-4-one (78.0 μL, 0.53 mmol) and NaBH(OAc)3 (111 mg, 0.50 mmol) were added. The reaction mixture was stirred for 3 d. Further 1-(propan-2-yl)piperidin-4-one (78.0 μL, 0.53 mmol) and NaBH(OAc)3 (111 mg, 0.50 mmol) were added and the reaction mixture was stirred overnight. The reaction mixture was diluted with DCM (10 mL), quenched with water (5 mL) and the organic fraction was washed with sat aq Na2CO3 (5 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (22.0 mg, 11%) as a white solid. HRMS (ESI+) calculated for C24H34N6O: 422.27941, found 422.28129. HPLC: Rf 3.53 min, 100% purity.
-
- Example 250 was prepared similarly to Example 242 using Intermediate 239 instead of Intermediate 237, to give the title compound (19%) as a colourless gum. HRMS (ESI+) calculated for C23H39N5O2: 417.310376, found 417.312286. HPLC: Rf 3.99 min, 100% purity.
-
- Intermediate 83 (256 mg, 0.86 mmol) was dissolved in DCM (15 mL), 2-chloro-4-fluorobenzaldehyde (149 mg, 0.94 mmol) and NaBH(OAc)3 (907 mg, 4.28 mmol) were added and the reaction mixture was stirred for 18 h. The reaction mixture was diluted with DCM (30 mL), washed with sat aq Na2CO3 (35 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (116 mg, 31%) as a light yellow gum. HRMS (ESI+) calculated for C23H23C1FN5O: 439.157516, found 439.157156. HPLC: Rf 4.40 min, 100% purity.
-
- Intermediate 81 (100 mg, 0.36 mmol), K2CO3 (75.6 mg, 0.55 mmol) and Intermediate 244 (98.2 mg, 0.36 mmol) were dissolved in MeCN (2 mL) and heated at 70° C. for 18 h. The reaction mixture was filtered, washing with DCM (20 mL) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (28.4 mg, 17%) as a yellow gum. HRMS (ESI+) calculated for C27H37N5O: 447.299811, found 447.298621. HPLC: Rf 4.18 min, 97.5% purity.
-
- Example 253 was prepared similarly to Example 252, using Intermediate 245 instead of Intermediate 244, to give the title compound as a colourless gum (15.3 mg, 10%). HRMS (ESI+) calculated for C22H33F2N5O: 421.265317, found 421.265627. HPLC: Rf 3.85 min, 98.8% purity.
-
- Intermediate 246 (206 mg, 0.51 mmol) was dissolved in IPA (10 mL), isopropylamine (151 mg, 2.55 mmol) was added and the reaction mixture was heated at reflux for 3 h. The reaction mixture was concentrated in vacuo and purified by column chromatography to give the title compound (192 mg, 88%) as a white solid. HRMS (ESI+) calculated for C23H34N6O2: 426.274324, found 426.276264. HPLC: Rf 2.98 min, 98.3% purity.
-
- Intermediate 106 (520 mg, 1.37 mmol) and 4-(pyrrolidin-1-yl)cyclohexan-1-one (687 mg, 4.11 mmol) were dissolved in DCM (10 mL) and NaBH(OAc)3 (1.02 g, 4.80 mmol) was added. The reaction mixture was stirred overnight, poured into 1 M aq Na2CO3 (25 mL) and extracted with DCM (3×25 mL). The combined organic fractions were dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (31.0 mg, 5%) as a white solid. HRMS (ESI+) calculated for C26H38N6: 435.32307, found 435.32434. HPLC: Rf 3.68 min, 99.7% purity.
-
- Intermediate 134 (100 mg, 0.28 mmol), 3-(aminomethyl)-pyridine (45.1 mg, 0.42 mmol), HBTU (106 mg, 0.28 mmol) and DIPEA (108 mg, 0.83 mmol) were dissolved in DMF (2 mL) and stirred for 4 h. The solvents were removed in vacuo and the residue purified by reverse phase HPLC to give the title compound (2.87 mg, 2%) as a colourless gum. HRMS (ESI+) calculated for C27H39N5O: 449.315461, found 449.316351. HPLC: Rf 4.77 min, 99.2% purity.
-
- Intermediate 83 (100 mg, 0.34 mmol), 4-(2-trifluoromethyl-pyrrolidin-1-yl)-cyclohexanone (98.9 mg, 0.42 mmol) and NaBH(OAc)3 (356 mg, 1.68 mmol) were stirred for 7 d. The reaction mixture was diluted with DCM (15 mL), washed with sat aq Na2CO3 (25 mL), brine (20 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (5.67 mg, 3%) as a light yellow gum. HRMS (ESI+) calculated for C27H35F3N6O: 516.282444, found 516.281974. HPLC: Rf 4.11 min, 99.2% purity.
-
- Intermediate 253 (200 mg, 0.43 mmol) and hydrazine monohydrate (27.8 mg, 0.87 mmol) were dissolved in EtOH (20 mL) and the reaction mixture was stirred for 6 h. The solvents were removed in vacuo and 2-chlorobenzaldehyde (122 mg, 0.87 mmol), DCM (10 mL) and NaBH(OAc)3 (459 mg, 2.17 mmol) were added. The reaction mixture was stirred for 18 h. The reaction mixture was diluted with DCM (50 mL), washed with sat aq Na2CO3 (40 mL), brine (30 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to the title compound (13.2 mg, 7%) as a colourless gum. HRMS (ESI+) calculated for C25H34C1N5O: 455.245188, found 455.245878. HPLC: Rf 4.36 min, 99.1% purity.
-
- Example 136 (50.0 mg, 0.12 mmol) was dissolved in THF (1 mL), the reaction mixture was cooled to −5° C. and trifluoroacetic anhydride (19.8 μL, 0.14 mmol) and Et3N (39.0 μL, 0.28 mmol) were added. The reaction mixture was stirred for 5 h, concentrated in vacuo, diluted with DCM (20 mL), washed with sat aq Na2CO3 (10 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (12.4 mg, 26%) as a yellow solid. HRMS (ESI+) calculated for C23H28C1N5: 409.203324, found 409.203394. HPLC: Rf 4.32 min, 98.1% purity.
-
- Intermediate 133 (190 mg, 0.43 mmol) was dissolved in MeOH (5 mL) and the reaction mixture was cooled to 0° C. NaBH4 (64.9 mg, 1.72 mmol) was added and the reaction mixture was stirred at 60° C. for 2 d. Further NaBH4 (64.9 mg, 1.72 mmol) was added and the reaction mixture was stirred at 60° C. for 3 d. The solvents were removed in vacuo and the residue was partitioned between DCM (25 mL) and sat aq Na2CO3 (20 mL). The organic fraction was dried (MgSO4) and concentrated in vacuo. The residue was purified by reverse phase HPLC to give the title compound (31.4 mg, 18%) as an off-white solid. HRMS (ESI+) calculated for C23H31C1N4O: 414.218639, found 414.218919. HPLC: Rf 3.37 min, 100% purity.
-
- Intermediate 258 (361 mg, 1.39 mmol) was dissolved in DCM (15 mL), 2-chlorobenzaldehyde (343 μL, 3.05 mmol) and NaBH(OAc)3 (1.18 g, 5.55 mmol) were added and the reaction mixture was stirred for 18 h. The reaction mixture was diluted with DCM (30 mL) and quenched with water (15 mL). The organic fraction was washed with sat aq Na2CO3 (15 mL), dried (MgSO4) and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (49.4 mg, 9%) as a colourless gum. HRMS (ESI+) calculated for C22H29C1N4: 384.208075, found 384.208755. HPLC: Rf 3.34 min, 99.2% purity.
- Examples 262-264 were prepared similarly to Example 261, using Intermediates 259-261 instead of Intermediate 258; see Table 25 below.
-
TABLE 25 Reductive alkylation reactions of Intermediates 259-261 Ex Structure Name Ints Yield HRMS (ESI+), HPLC 262 1-{1-[(2-Chlorophenyl) methyl]piperidin- 4-yl]-4-(6-methyl- pyridin-2-yl)-1,4- diazepane 259 24% HRMS (ESI+) calculated for C23H31C1N4: 398.223725, found 398.223905. HPLC: Rf 3.47 min, 100% purity. 263 1-{1-[(2-Chlorophenyl) methyl]piperidin- 4-yl}-4-(5-methyl- pyridin-2-yl)-1,4- diazepane 260 35% HRMS (ESI+) calculated for C23H31C1N4: 398.223725, found 398.224045. HPLC: Rf 3.50 min, 100% purity. 264 1-{1-[(2-Chlorophenyl) methyl]piperidin- 4-yl}-4-(4-methyl- pyridin-2-yl)-1,4- diazepane 261 21% HRMS (ESI+) calculated for C23H31C1N4: 398.223725, found 398.224295. HPLC: Rf 3.44 min, 99.1% purity. -
- Intermediate 264 (100 mg, 0.38 mmol) and Intermediate 263 (589 mg, 1.91 mmol) were dissolved in DMA (2 mL) and the reaction mixture was heated using a microwave (180° C., absorption high) for 20 min. The reaction mixture was partitioned between DCM (40 mL) and sat aq Na2CO3 (20 mL). The organic fraction was washed with brine (20 mL), dried (MgSO4) and concentrated in vacuo. The residue was dissolved in DCM, stirred with isocyanate resin, for 3 h and filtered. The solvents were removed in vacuo and the residue was purified by column chromatography and reverse phase HPLC to give the title compound (20.4 mg, 11%) as an off-white solid. HRMS (ESI+) calculated for C25H34C1N5OS: 487.217259, found 487.217919. HPLC: Rf 4.14 min, 99.5% purity.
-
- Example 266 was prepared similarly to Example 265, using Intermediate 265 instead of Intermediate 264, to give the title compound (2%) as a yellow gum. HRMS (ESI+) calculated for C29H39C1N8O: 550.293536, found 550.293396. HPLC: Rf 3.70 min, 100% purity.
-
- 2-Bromothiazole (234 mg, 1.43 mmol) was dissolved in dioxane (2 mL) and sodium tert-butoxide (175 mg, 1.82 mmol), Pd2(dba)3 (47.6 mg, 0.05 mmol), Xantphos (84.9 mg, 0.10 mmol) and Intermediate 263 (400 mg, 1.30 mmol) were added. The reaction mixture was heated at 106° C. for 3 d and the solvents were removed in vacuo. The residue was dissolved in DCM, filtered and concentrated in vacuo. The residue was purified by column chromatography and reverse phase HPLC to give the title compound (39.7 mg, 8%) as a yellow gum. HRMS (ESI+) calculated for C20H27C1N4S: 390.164495, found 390.164375. HPLC: Rf 3.38 min, 99.3% purity.
-
- Example 268 was prepared similarly to Example 267, using Intermediate 266 instead of 2-bromothiazole, to give the title compound (4%) as a yellow gum. HRMS (ESI+) calculated for C28H38C1N5O: 495.276489, found 495.277109. HPLC: Rf 4.51 min, 100% purity.
-
- Example 269 was prepared similarly to Example 132, using Intermediate 269 instead of Intermediate 119, to give the title compound (12%) as an off-white solid. HRMS (ESI+) calculated for C27H36C1N5O: 481.260839, found 481.262979. HPLC: Rf 3.84 min, 98.8% purity.
-
- Example 270 was prepared similarly to Example 132, using Intermediate 272 instead of Intermediate 119, to give the title compound (6%) as a colourless gum. HRMS (ESI+) calculated for C28H38C1N5O2: 511.271403, found 511.273083. HPLC: Rf 4.37 min, 100% purity.
- The functional activity of test compounds was routinely tested by measuring the ability of compounds to antagonize CXCR4 activity in a dose dependent manner, using a calcium flux Fluorescent Imaging Plate Reader FLIPR assay.
- Human CXCR4 transfected HEK293 cells were cultured in Dulbecco's modified Eagles medium containing 4.5 g/L glucose, L-glutamine, pyruvate, 50 μg/mL Geneticin and 250 μg/mL hygromycin B and maintained at 37° C. in a humidified, 5% CO2 controlled atmosphere. Subcultivations were performed every 2-3 d.
- At confluence the cells were lifted using Ca2+ and Mg2+ free PBS/0.02% (w/v) EDTA, spun at 1000 rpm for 3 min and resuspended at 2.5×105 cells/mL. Cells were plated into a 384 well, poly-d-lysine coated, black with clear bottomed plate (Becton Dickinson) at 7500 cells/well. The plates were incubated overnight at 37° C. under 5% CO2. On the day of the experiment the cells were washed with incubation Buffer (HBSS containing 2.5 mM probenecid, 0.1% w/v BSA and 10 mM HEPES, pH 7.4 at 37° C.). After washing, the cells were loaded with Fluo-4 AM dye (Molecular probes) at 204 containing 0.48 μg/mL pluronic acid for 60 min at 37° C. under 5% CO2. After thorough washing with incubation buffer the cells were preincubated for 10 min at 37° C. before use.
- A combined agonist/antagonist protocol was used to measure changes in intracellular calcium concentration. Compound (antagonist) was added to the cell plate using a Fluorometric Imaging Plate Reader (FLIPR) (Molecular Devices, Sunnyvale, Calif., USA). Basal fluorescence was recorded every second for 10 seconds prior to compound addition (10 μl) and fluorescence recorded every second for 1 min then every 6 seconds for a further 1 min. SDF1α (EC50 concentration) was then added using the FLIPR and fluorescence recorded as described above. Curve-fitting and parameter estimation were carried out using GraphPad Prism 4.0 (GraphPad Software Inc., San Diego, Calif.).
- All of the exemplified compounds of the invention were found to be highly potent inhibitors of CXCR4 (See Table 26).
-
TABLE 26 CXCR4 functional activity CXCR4 Example fKi 1 C 2 C 3 C 4 C 5 B 6 C 7 B 8 C 9 C 10 C 11 C 12 C 13 C 14 B 15 C 16 C 17 D 18 C 19 C 20 C 21 C 22 C 23 A 24 B 25 C 26 B 27 B 28 A 29 B 30 A 31 A 32 A 33 B 34 A 35 C 36 A 37 C 38 B 39 B 40 A 41 B 42 B 43 B 44 B 45 B 46 B 47 A 48 C 49 C 50 C 51 B 52 B 53 B 54 A 55 B 56 A 57 B 58 C 59 C 60 D 61 C 62 D 63 A 64 B 65 A 66 B 67 D 68 C 69 C 70 B 71 D 72 B 73 B 74 C 75 C 76 B 77 B 78 A 79 A 80 A 81 A 82 A 83 A 84 A 85 B 86 A 87 A 88 A 89 B 90 B 91 C 92 B 93 B 94 C 95 C 96 B 97 C 98 B 99 B 100 B 101 C 102 D 103 C 104 D 105 D 106 A 107 B 108 A 109 B 110 B 111 A 112 D 113 C 114 C 115 C 116 A 117 C 118 B 119 A 120 B 121 A 122 A 123 A 124 B 125 C 126 D 127 B 128 C 129 D 130 C 131 C 132 B 133 B 134 C 135 A 136 C 137 B 138 D 139 C 140 D 141 A 142 B 143 C 144 C 145 A 146 C 147 B 148 B 149 A 150 B 151 C 152 C 153 D 154 C 155 C 156 B 157 C 158 D 159 D 160 C 161 C 162 C 163 C 164 B 165 C 166 C 167 B 168 C 169 D 170 C 171 D 172 C 173 D 174 C 175 A 176 A 177 A 178 B 179 A 180 A 181 B 182 B 183 C 184 B 185 C 186 A 187 B 188 A 189 A 190 A 191 A 192 B 193 A 194 B 195 A 196 B 197 B 198 C 199 D 200 D 201 C 202 D 203 A 204 A 205 A 206 A 207 A 208 C 209 C 210 A 211 B 212 C 213 B 214 C 215 B 216 C 217 C 218 C 219 C 220 B 221 C 222 D 223 D 224 A 225 A 226 A 227 A 228 A 229 C 230 C 231 C 232 C 233 D 234 C 235 C 236 C 237 C 238 C 239 C 240 B 241 B 242 C 243 C 244 B 245 B 246 B 247 B 248 D 249 C 250 B 251 C 252 D 253 D 254 C 255 C 256 B 257 D 258 C 259 D 260 D 261 C 262 D 263 C 264 C 265 D 266 C 267 C 268 C 269 C 270 C (A: <20 nM, B: 20-100 nM, C: 100-500 nM, D: 500-1000 nM) - Example 30 has demonstrated potent activity in two in vitro assays indicating potential utility of test compounds for treatment of HIV.
- Example 30 was tested in an HIV attachment assay, which detects compounds that block HIV-1IIIB (CXCR4-tropic) virus attachment to cells.
- The CXCR4-tropic HIV-1 attachment assay uses MAGI-CCR5 cells that naturally express CXCR4 which were engineered to express high levels of CD4 and CCR5 and to contain one copy of the HIV-1 LTR promoter driving expression of the β-galactosidase gene upon HIV-1 Tat transactivation. Cells are incubated with Example 30 and the CXCR4-tropic virus HIV-1IIIB for 3 hours before washing to remove drug and unbound virus. Fresh media is added and the plates are incubated for 48 hours after which antiviral efficacy is measured as the inhibition of β-galactosidase reporter expression and cytotoxicity is monitored by MTS staining.
-
FIG. 1 shows the effect of Example 30 in the CXCR4-tropic HIV-1 attachment assay. More specifically,FIG. 1 shows that Example 30 inhibits attachment of CXCR4-tropic HIV-1, with an IC50 of 40 nM. - Example 30 was also tested in an HIV antiviral assay that detects compounds that block HIV-1IIIB (CXCR4-tropic) replication via targets in the viral life cycle. The anti-viral assay uses MAGI-CCR5 cells that naturally express CXCR4 which were engineered to express high levels of CD4 and CCR5 and to contain one copy of the HIV-1 LTR promoter driving expression of the β-galactosidase gene upon
HIV 1 Tat transactivation. Cells are incubated with Example 30 and the CXCR4-tropic virus HIV-1IIIB for 48 hours after which antiviral efficacy is measured as the inhibition of β-galactosidase reporter expression and cytotoxicity is monitored by MTS staining. -
FIG. 2 shows the effect of Example 30 in the HIV anti-viral assay. More specifically,FIG. 2 shows that Example 30 inhibited HIV-1 antiviral activity, with an IC50 of 30 nM. - The study investigated the ability of Example 30 alone and in combination with G-CSF to induce in vivo mobilization of white blood cells in C57BL/6 mice, as well as hematopoietic progenitors from bone marrow to peripheral blood as assessed by the evaluation of the frequency of colony forming cell colonies (CFC). Peripheral blood samples from each test group were collected 1 hour post injection. The white blood cell count (WBC) was determined from the peripheral blood collected for each individual mouse. Clonogenic progenitors of the multipotential (CFU-GEMM) lineages were assessed. Peripheral blood cells were added to MethoCult® 3434 in triplicate cultures for plating (0.5-3×105 cells/dish). Cultures were incubated for 8 days at 37° C., 5% CO2 in humidified incubators. CFU-GEMM colony number was enumerated microscopically using an inverted microscope from appropriately plated culture dishes.
-
FIG. 3 shows a significant increase in circulating white blood cells (WBC) 1 hour after treatment with Example 30 when compared to mice in the vehicle control group. Treatment with G-CSF also resulted in an increase in circulating WBC compared to the vehicle group. There was a significant increase in WBC with Example 30 in combination with G-CSF after 1 hour when compared to mice treated with G-CSF alone. -
FIG. 4 shows the evaluation of hematopoietic progenitors following treatment with Example 30 and/or G-CSF. In particular,FIG. 4 shows a significant increase in multipotential mixed hematopoietic progenitors (CFU-GEMM/ml) one hour after treatment with Example 30 in combination with G-CSF when compared to G-CSF treatment alone. The results shown inFIGS. 3 and 4 support the utility of Example 30 and the compounds of the invention generally in stem cell apheresis, particularly therapeutic uses of stem cell apheresis.
Claims (21)
1-20. (canceled)
21. A method of treating a viral infection in a subject in need thereof, the method comprising administering to the subject an effective amount of a compound having a structure represented by a formula:
wherein:
R1 is selected from cyano, —COR3, —CONR3R4, and heteroaryl;
Y is selected from a radical of formula (H) and (J), which is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, C1-4-alkoxy, and fluoro-C1-4-alkoxy, wherein the bond marked * is attached to
and the bond marked ** is attached to R2:
n and m are each independently 1 or 2;
R2 is selected from radicals of formulae (N)-(S) inclusive, any of which is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl, and fluoro-C1-4-alkoxy, wherein the bond marked * is attached to Y
o and p are each independently 1 or 2;
W is O or NR9;
R3 is selected from hydrogen, C1-6-alkyl, C3-5-cycloalkyl, C3-5-cycloalkyl-C1-4-alkyl, heterocyclyl, heterocyclyl-C1-4-alkyl, C6-10-aryl, heteroaryl, C6-10-aryl-C1-4-alkyl, and heteroaryl-C1-4-alkyl, wherein:
(i) the C1-6-alkyl, the C3-5-cycloalkyl, the heterocyclyl, the heterocyclyl part of the heterocyclyl-C1-4-alkyl, the C1-4-alkyl part of the heterocyclyl-C1-4-alkyl, the C6-10-aryl-C1-4-alkyl, or the heteroaryl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxy, cyano, C1-4-alkoxy, and —NR5AR5B, and
(ii) the C6-10-aryl, the heteroaryl, the C6-10-aryl part of the C6-10-aryl-C1-4-alkyl or the heteroaryl part of the heteroaryl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl, fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl, fluoro-C1-4-alkoxy-C1-4-alkyl, —NR5AR5B, —C1-4-alkyl-NR5AR5B, —NR4C(O)O—C1-4alkyl, —NR4C(O)—C1-4alkyl, —NR4C(O)O-fluoro-C1-4alkyl, —NR4C(O)-fluoro-C1-4alkyl, —NR4C(O)NR5AR5B, —C(O)NR5AR5B, —C(O)OR4, —C(O)OR4, —NR4S(O)2—C1-4alkyl, and —NR4S(O)2-fluoro-C1-4alkyl;
R4, R5A, and R5B are each independently selected from hydrogen, C1-4-alkyl, and fluoro-C1-4-alkyl,
or
R5A and R5B, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring or a heteroaryl ring, the ring being optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl, and C1-4-alkoxy,
or
R3 and R4, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring or a heteroaryl ring, the ring being optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl, and C1-4-alkoxy;
R6 is selected from C1-6-alkyl, C3-5-cycloalkyl, C3-5-cycloalkyl-C1-4-alkyl, heterocyclyl, heterocyclyl-C1-4-alkyl, and C6-10-aryl, wherein:
(i) the C1-6-alkyl, the C3-5-cycloalkyl, the heterocyclyl, or the C1-4-alkyl part of the heterocyclyl-C1-4-alkyl, or the heterocyclyl part of the heterocyclyl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, and C1-4-alkoxy, and
(ii) the C6-10-aryl is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl, fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl, and fluoro-C1-4-alkoxy-C1-4-alkyl;
R7 is selected from C1-6-alkyl, C3-5-cycloalkyl, C3-5-cycloalkyl-C1-4-alkyl, heterocyclyl, heterocyclyl-C1-4-alkyl, C6-10-aryl-C1-4-alkyl, C6-10-aryl, and —NR10AR10B wherein:
(i) the C1-6-alkyl, the C3-5-cycloalkyl, the heterocyclyl, the C1-4-alkyl part of the heterocyclyl-C1-4-alkyl or the C6-10-aryl-C1-4-alkyl, or the heterocyclyl part of the heterocyclyl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, and C1-4-alkoxy, and
(ii) the C6-10-aryl or the C6-10-aryl part of the C6-10-aryl-C1-4-alkyl is optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, nitro, C1-4-alkyl, C1-4-alkoxy, fluoro-C1-4-alkyl, fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl, and fluoro-C1-4-alkoxy-C1-4-alkyl;
R8A, R8B and R9 are each independently selected from hydrogen, C3-5-cycloalkyl, C1-6-alkyl, and C6-10-aryl-C1-4-alkyl wherein any alkyl residue or cycloalkyl or C6-10-aryl ring system is optionally substituted with one or more substituents independently selected from halogen, hydroxyl, and C1-4-alkoxy,
or
R8A and R8B, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring which is optionally fused to a C6-10-aryl or heteroaryl ring system, the 4- to 7-membered saturated heterocyclic ring or the C6-10-aryl or heteroaryl ring systems being optionally substituted with one or more substituents independently selected from halogen, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl, and C1-4-alkoxy; and
R10A and R10B are each independently selected from hydrogen and C1-6-alkyl, wherein the C1-6-alkyl is optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, and C1-4-alkoxy,
or
R10A and R10B, together with the nitrogen atom to which they are bound, form a 4- to 7-membered saturated heterocyclic ring or a heteroaryl ring, optionally substituted with one or more substituents independently selected from fluorine, hydroxyl, C1-4-alkyl, fluoro-C1-4-alkyl, and C1-4-alkoxy,
or a pharmaceutically acceptable salt thereof.
22. The method according to claim 21 , wherein R1 is —CONR3R4.
23. The method according to claim 22 , wherein R4 is hydrogen or methyl.
24. The method according to claim 22 , wherein R3 is tetrahydropyranyl, isopropylmethyl, tetrahydropyranylmethyl, imidazolylethyl, methoxyethyl, N-methylimidazolylmethyl, tetrahydrofuranylmethyl, 1-fluoroethyl, oxazolylmethyl, pyridylmethyl, 2,2-difluoromethyl, tetrahydrofuranyl, methyl, ethyl, n- or iso-propyl, n-sec- or n-sec- or tert-butyl, cyclopropyl, hydroxyethyl, cyanoethyl, phenyl, chlorophenyl, methoxyphenyl, methylphenyl, hydroxyphenyl, thiazoloylmethyl, indolyl, methoxypropyl, tetrahydroisoquinolinyl, furylmethyl, pyridylethyl, thiazolyl, or cyclopropylmethyl.
25. The method according to claim 22 , wherein R3 is pyridyl optionally substituted with one or more substituents selected from halogen, C1-4-alkyl, C1-4-alkoxy, and fluoro-C1-4-alkyl.
26. The method according to claim 21 , wherein R6 is C1-6-alkyl, C1-6 fluoroalkyl, C3-5 cycloalkyl, or C3-5 fluorocycloalkyl.
27. The method according to claim 21 , wherein R3 is C3-5-cycloalkyl-C1-4-alkyl, heterocyclyl, or heterocyclyl-C1-4-alkyl, and wherein R4 is hydrogen or methyl.
28. The method according to claim 21 , wherein R1 is selected from cyano, —COR5, —CONR3R4, and heteroaryl, wherein the heteroaryl has 5 to 10 ring atoms in which one or more of the ring atoms is N, S, or O, and is optionally substituted with one or more groups selected from fluoro, chloro, bromo hydroxy, cyano, nitro, C1-6-alkyl, C3-5-cycloalkyl, C1-4-alkoxy, fluoro-C1-6-alkyl, fluoro-C1-4-alkoxy, C1-4-alkoxy-C1-4-alkyl, fluoro-C1-4-alkoxy-C1-4-alkyl, C6-10-aryl, —NR5AR5B, —C1-4-alkyl-NR5AR5B, —NR4C(O)O—C1-4-alkyl, —NR4C(O)—C1-4-alkyl, —NR4C(O)O-fluoro-C1-4-alkyl, —NR4C(O)-fluoro-C1-4-alkyl, —NR4C(O)NR5AR5B, —C(O)NR5AR5B, —C(O)R4, —C(O)OR4, —NR4S(O)2—C1-4-alkyl, and —NR4S(O)2-fluoro-C1-4-alkyl.
31. The method according to claim 21 , wherein R6 is isopropyl.
32. The method according to claim 21 , wherein R1 is heteroaryl.
34. The method according to claim 33 , wherein R1 is heteroaryl.
38. The method according to claim 21 , wherein the viral infection is HIV/AIDS.
40. The method according to claim 39 , wherein the viral infection is HIV/AIDS.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17/190,266 US20220348577A1 (en) | 2010-10-14 | 2021-03-02 | CXCR4 Receptor Antagonists |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB201017345A GB201017345D0 (en) | 2010-10-14 | 2010-10-14 | Receptor antagonists |
US201313878968A | 2013-06-11 | 2013-06-11 | |
US14/852,835 US20160046606A1 (en) | 2010-10-14 | 2015-09-14 | CXCR4 Receptor Antagonists |
US15/497,324 US10155761B2 (en) | 2010-10-14 | 2017-04-26 | CXCR4 receptor antagonists |
US16/167,084 US10995091B2 (en) | 2010-10-14 | 2018-10-22 | CXCR4 receptor antagonists |
US17/190,266 US20220348577A1 (en) | 2010-10-14 | 2021-03-02 | CXCR4 Receptor Antagonists |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/167,084 Continuation US10995091B2 (en) | 2010-10-14 | 2018-10-22 | CXCR4 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
US20220348577A1 true US20220348577A1 (en) | 2022-11-03 |
Family
ID=43304554
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/878,968 Expired - Fee Related US9353086B2 (en) | 2010-10-14 | 2011-10-13 | CXCR4 receptor antagonists |
US14/852,835 Abandoned US20160046606A1 (en) | 2010-10-14 | 2015-09-14 | CXCR4 Receptor Antagonists |
US15/497,324 Active US10155761B2 (en) | 2010-10-14 | 2017-04-26 | CXCR4 receptor antagonists |
US16/167,084 Active US10995091B2 (en) | 2010-10-14 | 2018-10-22 | CXCR4 receptor antagonists |
US17/190,266 Abandoned US20220348577A1 (en) | 2010-10-14 | 2021-03-02 | CXCR4 Receptor Antagonists |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/878,968 Expired - Fee Related US9353086B2 (en) | 2010-10-14 | 2011-10-13 | CXCR4 receptor antagonists |
US14/852,835 Abandoned US20160046606A1 (en) | 2010-10-14 | 2015-09-14 | CXCR4 Receptor Antagonists |
US15/497,324 Active US10155761B2 (en) | 2010-10-14 | 2017-04-26 | CXCR4 receptor antagonists |
US16/167,084 Active US10995091B2 (en) | 2010-10-14 | 2018-10-22 | CXCR4 receptor antagonists |
Country Status (16)
Country | Link |
---|---|
US (5) | US9353086B2 (en) |
EP (2) | EP2627649B1 (en) |
JP (2) | JP5881718B2 (en) |
CN (1) | CN103282360B (en) |
AU (1) | AU2011315498C1 (en) |
BR (1) | BR112013009036B1 (en) |
CA (1) | CA2814419C (en) |
DK (2) | DK2627649T3 (en) |
ES (2) | ES2536281T3 (en) |
GB (1) | GB201017345D0 (en) |
HK (1) | HK1188211A1 (en) |
IL (1) | IL225550A (en) |
PL (2) | PL2627649T3 (en) |
PT (2) | PT2627649E (en) |
SG (1) | SG189387A1 (en) |
WO (1) | WO2012049277A1 (en) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201017345D0 (en) * | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
US8629274B2 (en) | 2011-12-21 | 2014-01-14 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
TW201920090A (en) | 2012-08-28 | 2019-06-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis B |
MX359651B (en) | 2012-11-29 | 2018-10-05 | Chemocentryx Inc | Cxcr7 antagonists. |
CN105164107B (en) * | 2012-12-20 | 2017-12-05 | 卢庆彬 | For with radiating the radiosensitization immunomodulator compounds being used in combination |
EP2746259A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
EP2746260A1 (en) | 2012-12-21 | 2014-06-25 | Basf Se | Substituted [1,2,4]triazole and imidazole compounds |
SI2961732T1 (en) | 2013-02-28 | 2017-07-31 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
MX353412B (en) | 2013-04-03 | 2018-01-10 | Janssen Sciences Ireland Uc | N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b. |
JO3603B1 (en) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
WO2015011281A1 (en) | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
SG11201602748XA (en) | 2013-10-23 | 2016-05-30 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
MX2016009449A (en) | 2014-02-05 | 2016-10-13 | Novira Therapeutics Inc | Combination therapy for treatment of hbv infections. |
CA2932551A1 (en) | 2014-02-06 | 2015-08-13 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
WO2016149581A1 (en) | 2015-03-19 | 2016-09-22 | Novira Therapeutics, Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
SG10201909188XA (en) * | 2015-04-02 | 2019-11-28 | Proximagen Llc | Novel therapies for cancer |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
US10709697B2 (en) | 2015-07-16 | 2020-07-14 | Emory University | Bis-amines, compositions, and uses related to CXCR4 inhibition |
WO2017059059A1 (en) | 2015-09-29 | 2017-04-06 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis b antiviral agent |
US11357742B2 (en) | 2015-12-14 | 2022-06-14 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
WO2017106328A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
US10610527B2 (en) | 2015-12-22 | 2020-04-07 | X4 Pharmaceuticals, Inc. | Methods for treating immunodeficiency disease |
GB201604213D0 (en) | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
JP2019510785A (en) | 2016-04-08 | 2019-04-18 | エックス4 ファーマシューティカルズ, インコーポレイテッド | How to treat cancer |
BR112018071048A2 (en) | 2016-04-15 | 2019-05-07 | Janssen Sciences Ireland Uc | combinations and methods comprising a capsid assembly inhibitor |
EP3246330A1 (en) | 2016-05-18 | 2017-11-22 | Istituto Europeo di Oncologia S.r.l. | Imidazoles as histone demethylase inhibitors |
CA3027498A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
CN109641838A (en) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | CXCR4 inhibitor and application thereof |
JP7084624B2 (en) | 2016-06-21 | 2022-06-15 | エックス4 ファーマシューティカルズ, インコーポレイテッド | CXCR4 inhibitor and its use |
TW201811799A (en) | 2016-09-09 | 2018-04-01 | 美商英塞特公司 | Pyrazolopyrimidine compounds and uses thereof |
US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
EP3510032B1 (en) | 2016-09-09 | 2022-07-06 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
WO2018152220A1 (en) | 2017-02-15 | 2018-08-23 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
GB201703907D0 (en) | 2017-03-10 | 2017-04-26 | Proximagen Ltd | Novel therapies for cancer |
US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
CN109553604B (en) * | 2017-09-25 | 2021-08-27 | 盛世泰科生物医药技术(苏州)有限公司 | 4-aminopyrimidine derivatives as CXCR4 inhibitors and uses thereof |
HRP20220833T1 (en) | 2018-02-20 | 2022-10-28 | Incyte Corporation | N-(phenyl)-2-(phenyl)pyrimidine-4-carboxamide derivatives and related compounds as hpk1 inhibitors for treating cancer |
US10752635B2 (en) | 2018-02-20 | 2020-08-25 | Incyte Corporation | Indazole compounds and uses thereof |
US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
US10973801B2 (en) | 2018-03-14 | 2021-04-13 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
US11111247B2 (en) | 2018-09-25 | 2021-09-07 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
CN113194956A (en) | 2018-12-12 | 2021-07-30 | 凯莫森特里克斯股份有限公司 | CXCR7 inhibitors for cancer treatment |
EP3897670A4 (en) | 2018-12-19 | 2022-09-07 | Disarm Therapeutics, Inc. | Inhibitors of sarm1 in combination with neuroprotective agents |
BR112021015618A2 (en) | 2019-02-22 | 2021-10-05 | Janssen Sciences Ireland Unlimited Company | AMIDE DERIVATIVES USEFUL IN THE TREATMENT OF HBV INFECTION OR HBV-INDUCED DISEASES |
WO2020222190A1 (en) | 2019-05-02 | 2020-11-05 | Proximagen, Llc | Crystalline form of 6-[4-[1 -(propan-2-yl)piperidin-4-yl]-1,4-diazepan-1 -yl]-n-(pyrdin-4-yl)pyridine-2-carboxamide |
WO2020222189A1 (en) | 2019-05-02 | 2020-11-05 | Proximagen, Llc | Crystalline form of 6-[4-[1-(propan-2-yl)piperidin-4-yl]-1,4-diazepan-1-yl]-n-(pyrdin-4-yl)pyridine-2-carboxamide |
CN113795486A (en) | 2019-05-06 | 2021-12-14 | 爱尔兰詹森科学公司 | Amide derivatives for the treatment of HBV infection or HBV-induced diseases |
AR119009A1 (en) * | 2019-05-29 | 2021-11-17 | Syngenta Crop Protection Ag | MICROBICIDE ALCOPYPYRIDINE AND ALCOXYPYRIMIDINE DERIVATIVES |
EP3996703A4 (en) * | 2019-07-08 | 2023-06-14 | The Board Of Regents Of The University Of Texas System | Use of immune modulators to improve nerve regeneration |
JP2022543155A (en) | 2019-08-06 | 2022-10-07 | インサイト・コーポレイション | Solid forms of HPK1 inhibitors |
CN115997122A (en) | 2020-06-26 | 2023-04-21 | 拉夸里亚创药株式会社 | Method for selecting cancer patients for whom combination therapy of retinoid with cancer therapeutic agent is effective, and combination drug of retinoid with cancer therapeutic agent |
CN113845439B (en) * | 2021-10-11 | 2024-02-09 | 杭州师范大学 | Bisbenzylamide CXCR4 antagonist and preparation and application thereof |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047406A (en) | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
GB9300194D0 (en) * | 1993-01-06 | 1993-03-03 | Wyeth John & Brother Ltd | Piperazine derivatives |
US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
AU5522498A (en) | 1996-12-13 | 1998-07-03 | Merck & Co., Inc. | Substituted aryl piperazines as modulators of chemokine receptor activity |
FR2769913B1 (en) | 1997-10-16 | 2000-03-10 | Pf Medicament | NEW CYCLOHEXANIC DERIVATIVES DIFUNCTIONALIZED IN 1, 4, THEIR PREPARATION AND THEIR HUMAN THERAPEUTIC APPLICATION |
SE9902987D0 (en) * | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
WO2002002539A1 (en) | 2000-06-29 | 2002-01-10 | Abbott Laboratories | Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents |
AR036366A1 (en) | 2001-08-29 | 2004-09-01 | Schering Corp | USEFUL PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS, THE USE OF SUCH DERIVATIVES FOR THE MANUFACTURE OF A MEDICINAL PRODUCT AND A KIT |
WO2003082855A1 (en) * | 2002-03-28 | 2003-10-09 | Kyowa Hakko Kogyo Co., Ltd. | Anti-inflammatory agent |
EP1571146A4 (en) | 2002-12-10 | 2010-09-01 | Ono Pharmaceutical Co | Nitrogen-containing heterocyclic compounds and medicinal use thereof |
GB0308466D0 (en) * | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
FR2854633B1 (en) | 2003-05-07 | 2005-06-24 | Sanofi Synthelabo | PIPERIDINYL-AND PIPERAZINYL-ALKYLCARBAMATES DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
US7498346B2 (en) | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
WO2005059107A2 (en) | 2003-12-11 | 2005-06-30 | Anormed Inc. | Chemokine receptor binding compounds |
WO2006071958A1 (en) | 2004-12-29 | 2006-07-06 | Millennium Pharmaceuticals, Inc. | Compounds useful as chemokine receptor antagonists |
US7880002B2 (en) * | 2004-12-29 | 2011-02-01 | Millennium Pharmaceuticals, Inc. | Substituted piperazinyl-pyrrolidine compounds useful as chemokine receptor antagonists |
EP1858895B1 (en) | 2005-02-16 | 2012-06-20 | Schering Corporation | Piperazine-piperidines with cxcr3 antagonist activity |
JP4688889B2 (en) | 2005-02-16 | 2011-05-25 | シェーリング コーポレイション | Piperazine-piperidine substituted with amine-linked pyridyl and phenyl having CXCR3 antagonist activity |
AU2006214378A1 (en) | 2005-02-16 | 2006-08-24 | Pharmacopeia, Inc. | Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity |
CA2598459A1 (en) | 2005-02-16 | 2006-08-24 | Schering Corporation | Novel heterocyclic substituted pyridine or phenyl compounds with cxcr3 antagonist activity |
JP2008530220A (en) * | 2005-02-16 | 2008-08-07 | シェーリング コーポレイション | Pyrazinyl-substituted piperazine-piperidine having CXCR3 antagonist activity |
EP1879881A2 (en) | 2005-04-14 | 2008-01-23 | Bristol-Myers Squibb Company | Inhibitors of 11-beta hydroxysteroid dehydrogenase type i |
WO2006130426A2 (en) | 2005-05-27 | 2006-12-07 | Kemia, Inc. | Modulators of ccr-5 activity |
GB0525957D0 (en) | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
MX2008012161A (en) | 2006-03-21 | 2008-10-03 | Schering Corp | Heterocyclic substituted pyridine compounds with cxcr3 antagonist activity. |
EP1849781A1 (en) * | 2006-04-28 | 2007-10-31 | Laboratorios del Dr. Esteve S.A. | Substituted 3-Amino-4-hydroxy pyrrolidines compounds, their preparation and use as medicaments |
KR20090043512A (en) * | 2006-07-14 | 2009-05-06 | 쉐링 코포레이션 | Heterocyclic substituted piperazine compounds with cxcr3 antagonist activity |
JP2008050220A (en) * | 2006-08-25 | 2008-03-06 | Hitachi Metals Ltd | Hexagonal crystal z-type ferrite sintered compact and method of manufacturing the same |
WO2008028553A1 (en) | 2006-09-02 | 2008-03-13 | Merck Patent Gmbh | Particle beam process for the alignment of reactive mesogens |
ES2396256T3 (en) | 2006-09-21 | 2013-02-20 | Kyorin Pharmaceutical Co., Ltd. | Serine hydrolase inhibitors |
CA2669917A1 (en) | 2006-11-17 | 2008-05-22 | Dawn M. George | Aminopyrrolidines as chemokine receptor antagonists |
CA2673231A1 (en) * | 2006-12-22 | 2008-07-03 | Schering Corporation | Heterocyclic compounds with cxcr3 antagonist activity |
CA2677096A1 (en) | 2007-01-31 | 2008-08-07 | Vertex Pharmaceuticals Incorporated | Kinase inhibitors |
WO2008121065A1 (en) * | 2007-03-30 | 2008-10-09 | Astrazeneca Ab | Novel pyrrolidine derivatives as antagonists of the chemokine receptor |
CA2707989A1 (en) * | 2007-12-07 | 2009-06-11 | Novartis Ag | Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases |
MX2011004490A (en) * | 2008-11-04 | 2011-07-20 | Chemocentryx Inc | Modulators of cxcr7. |
CA2767089A1 (en) * | 2009-07-15 | 2011-01-20 | Abbott Laboratories | Pyrrolopyridine inhibitors of kinases |
KR20110123657A (en) * | 2010-05-07 | 2011-11-15 | 에스케이케미칼주식회사 | Picolinamide and pyrimidine-4-carboxamide compounds, process for preparing and pharmaceutical composition comprising the same |
WO2012047339A2 (en) | 2010-06-28 | 2012-04-12 | The General Hospital Corporation | Anti-cxcr4 as a sensitizer to cancer therapeutics |
GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
SG10201909188XA (en) | 2015-04-02 | 2019-11-28 | Proximagen Llc | Novel therapies for cancer |
GB201604213D0 (en) | 2016-03-11 | 2016-04-27 | Proximagen Ltd | Drug combination and its use in therapy |
GB201703907D0 (en) | 2017-03-10 | 2017-04-26 | Proximagen Ltd | Novel therapies for cancer |
-
2010
- 2010-10-14 GB GB201017345A patent/GB201017345D0/en not_active Ceased
-
2011
- 2011-10-13 DK DK11773227.1T patent/DK2627649T3/en active
- 2011-10-13 PL PL11773227T patent/PL2627649T3/en unknown
- 2011-10-13 DK DK15158267.3T patent/DK2927224T3/en active
- 2011-10-13 EP EP11773227.1A patent/EP2627649B1/en active Active
- 2011-10-13 BR BR112013009036-7A patent/BR112013009036B1/en not_active IP Right Cessation
- 2011-10-13 CN CN201180049854.3A patent/CN103282360B/en active Active
- 2011-10-13 PL PL15158267T patent/PL2927224T3/en unknown
- 2011-10-13 ES ES11773227.1T patent/ES2536281T3/en active Active
- 2011-10-13 JP JP2013533225A patent/JP5881718B2/en active Active
- 2011-10-13 CA CA2814419A patent/CA2814419C/en active Active
- 2011-10-13 SG SG2013027800A patent/SG189387A1/en unknown
- 2011-10-13 US US13/878,968 patent/US9353086B2/en not_active Expired - Fee Related
- 2011-10-13 WO PCT/EP2011/067946 patent/WO2012049277A1/en active Application Filing
- 2011-10-13 PT PT117732271T patent/PT2627649E/en unknown
- 2011-10-13 EP EP15158267.3A patent/EP2927224B8/en active Active
- 2011-10-13 AU AU2011315498A patent/AU2011315498C1/en not_active Ceased
- 2011-10-13 ES ES15158267T patent/ES2699470T3/en active Active
- 2011-10-13 PT PT15158267T patent/PT2927224T/en unknown
-
2013
- 2013-04-04 IL IL225550A patent/IL225550A/en active IP Right Grant
-
2014
- 2014-02-10 HK HK14101177.7A patent/HK1188211A1/en not_active IP Right Cessation
-
2015
- 2015-09-14 US US14/852,835 patent/US20160046606A1/en not_active Abandoned
- 2015-09-28 JP JP2015189271A patent/JP6348891B2/en active Active
-
2017
- 2017-04-26 US US15/497,324 patent/US10155761B2/en active Active
-
2018
- 2018-10-22 US US16/167,084 patent/US10995091B2/en active Active
-
2021
- 2021-03-02 US US17/190,266 patent/US20220348577A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220348577A1 (en) | CXCR4 Receptor Antagonists | |
US10881652B2 (en) | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | |
ES2954152T3 (en) | Piperidine CXCR7 receptor modulators | |
CN114072397A (en) | Heteroaryl aminopyrimidine amide autophagy inhibitors and methods of use thereof | |
US11939328B2 (en) | Quinoline compounds as inhibitors of KRAS | |
US20190337946A1 (en) | Triazolopyridine compounds and methods of use thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |