US20220096752A1 - Auto-injection device - Google Patents
Auto-injection device Download PDFInfo
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- US20220096752A1 US20220096752A1 US17/549,120 US202117549120A US2022096752A1 US 20220096752 A1 US20220096752 A1 US 20220096752A1 US 202117549120 A US202117549120 A US 202117549120A US 2022096752 A1 US2022096752 A1 US 2022096752A1
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- injection device
- syringe
- springs
- casing
- activator
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3202—Devices for protection of the needle before use, e.g. caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3213—Caps placed axially onto the needle, e.g. equipped with finger protection guards
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2026—Semi-automatic, e.g. user activated piston is assisted by additional source of energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/2073—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically preventing premature release, e.g. by making use of a safety lock
- A61M2005/208—Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3216—Caps placed transversally onto the needle, e.g. pivotally attached to the needle base
- A61M2005/3217—Means to impede repositioning of protection cap from needle covering to needle uncovering position, e.g. catch mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/06—Packaging for specific medical equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31571—Means preventing accidental administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/321—Means for protection against accidental injuries by used needles
- A61M5/3216—Caps placed transversally onto the needle, e.g. pivotally attached to the needle base
- A61M5/3219—Semi-automatic repositioning of the cap, i.e. in which the repositioning of the cap to the needle covering position requires a deliberate action by the user to trigger the repositioning of the cap, e.g. manual release of spring-biased cap repositioning means
Abstract
Description
- This application is a continuation of U.S. patent application Ser. No. 17/090,236, titled “AUTO-INJECTION DEVICE” and filed on Nov. 5, 2020, which is a continuation of U.S. patent application Ser. No. 16/607,323, titled “AUTO-INJECTION DEVICE” and filed on Oct. 22, 2019, which is a 371 National Phase of PCT Application No. PCT/US2019/023417, titled “AUTO-INJECTION DEVICE” and filed on Mar. 21, 2019, which claims priority to U.S. Provisional Application No. 62/646,518, titled “Wearable Medical Drug Auto-Injector” and filed on Mar. 22, 2018, the entire contents of which are incorporated herein in their entirety.
- The present disclosure relates generally to medical devices, and more specifically to a light and compact auto-injection device suitable for wearing or carrying.
- Anaphylaxis is a life-threatening medical condition that affects millions of people across all ages. When an individual with this condition contacts or ingests an allergen they are sensitive to, such as nuts, insect venom, shellfish, etc., the individual's throat begins to swell and breathing becomes difficult. If the individual does not receive an adequate dose of proper medication administered in a prescribed way within a preferred time limit, the condition can be fatal. In the case of anaphylaxis, the procedure recommended by doctors is to administer epinephrine intramuscularly into the thigh within a few minutes of the onset of the medical condition.
- Anaphylaxis patients are encouraged to carry an epinephrine auto-injection device, e.g. EpiPen, that contains an effective dose of epinephrine and is ready for use by patients themselves. The auto-injection device can be activated by a stabbing motion at the injection site. After activation, the drug is automatically administered. Patients with other potentially life-threatening conditions, e.g., hyperglycemia, can also benefit from carrying or wearing an auto-injection device for emergency use.
- Prior art auto-injection devices are bulky and heavy. They are not convenient to be carried around. Nor can they be worn by users as a wearable device. The present application discloses an auto-injection device that is light and compact, suitable for wearing or carrying by users in their daily activities.
- Accordingly, it is an objective of the present disclosure to teach an auto-injection device that is light and compact and can be carried as a wearable device.
- In some embodiments, an exemplary auto-injection device comprises a syringe, a needle, and two sets of springs. The syringe comprises a plunger and a chamber for storing an injection substance. The needle is connected to and in communication with the syringe. In one embodiment, the needle and the syringe are coaxial. Each set of springs comprises one or more springs. The first set of springs is coupled to the syringe and configured to push the needle. The second set of springs is coupled to the plunger and configured to push the plunger. The auto-injection device may be housed in a casing. In one embodiment, the casing is sealed to prevent contamination. In another embodiment, the needle may be protected by a protective cover to prevent contamination.
- In some embodiments, each set of springs comprises a compressed state and a released state. The first set of springs is configured to move the needle outside of the casing when the first set of springs is in the released state. When the first set of springs is released, the second set of springs is released from its compressed state and drives the plunger to inject the substance stored in the chamber into the patient. In some embodiments, the first and second set of springs are released in sequence. The second set of springs is released after the first set of springs is released. In some embodiments, the first and second sets of springs may be released substantially simultaneously.
- In some embodiments, the auto-injection device comprises a first activator configured to release the first set of springs. In one embodiment, the syringe of the auto-injection device is configured to compress the first set of springs when resting on one or more cantilevers. The first activator is configured to bend or push the cantilevers and move the syringe off the cantilevers in order to release the first set of springs. Once released from the compressed state, the first set of springs pushes the needle outside the casing.
- In some embodiments, the auto-injection comprises a second activator configured to release the second set of springs. When the second set of springs is released from the compressed state, the second set of springs drives the plunger of the syringe to inject the substance stored in the chamber. In one embodiment, the second activator comprises a tube and a pin. The tube is configured with one or more cross-holes in the wall. The pin is inside the tube and is configured to move from an inserted position to a pulled-up position. One or more identical balls are held inside the cross-holes. The size of the balls is larger than the thickness of the wall of the tube. When the pin is in the inserted position, the balls are pushed by the pin to extrude outside the outer-wall of the tube and act as a stopper to hold the second set of springs in the compressed state. When the pin is in the pulled-up position, the one or more balls are configured to move towards the interior of the tube to release the second set of the springs. The released springs in the second set push the plunger to inject a stored substance.
- In some embodiments, the auto-injection device comprises a revolving sheath that blocks the needle after injection. The sheath is configured to move from a closed position to an open position. When in the closed position, the revolving sheath rests on the casing. When in the open position, the revolving sheath blocks the needle. In one embodiment, the revolving sheath is attached to the casing via a revolving peg.
- In some embodiments, a wearable device comprising a watch-sized case and an auto-injection cartridge is disclosed. The case comprises a frame, a cover and one or more outer-covers. The frame comprises two cantilevers attached to two opposing interior sides of the frame respectively. The auto-injection cartridge is inset onto the cantilevers. When the auto-injection cartridge slides off the cantilevers, the wearable device is activated. In one embodiment of the wearable device, a revolving sheath is attached to the cover to block the needle of the auto-injection cartridge after use.
- In some embodiments, a wearable device comprising a telescoping case and an auto-injection device is disclosed. The telescoping case changes shape by extension using a telescoping mechanism. In this embodiment, the case comprises two or more separate components that together enclose the auto-injection device. Attached to the rear section of the device are small snap-fit pieces that move parallel to the body of the device within a confined space. The confined space compresses the snap-fit pieces such that they are in a compressed state before being activated. When the snap-fit pieces exit the confined space, they are allowed to expand. In the expanded state, the snap-fit pieces cannot return to the confined space, so the rear section cannot be pushed back towards the needle tip. After the body of the device has expanded, the set of activation springs remain in a partially compressed state. This ensures that they can push the needle out of the device upon activation.
- These and other features of the present disclosure will become readily apparent upon further review of the following specification and drawings. In the drawings, like reference numerals designate like parts having similar functionality throughout the views. Like parts may be designed differently in different embodiments. Components in the drawings are not necessarily drawn to scale, the emphasis instead being placed upon clearly illustrating the principles of the present disclosure.
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FIG. 1 is a cross-section view of a first embodiment of an exemplary auto-injection device taught by the present disclosure. -
FIG. 2 illustrates the exemplary auto-injection device in an activated state. -
FIG. 3 illustrates the exemplary auto-injection device after injection. -
FIG. 4 illustrates an exemplary embodiment of the first activator. -
FIGS. 5a-5c illustrate an exemplary embodiment of the second activator. -
FIG. 6 illustrates different views of an exemplary syringe. -
FIG. 7 illustrates an exemplary design of the frame. -
FIG. 8 illustrates an exemplary design of the cover. -
FIG. 9 illustrates an exemplary design of the revolving sheath. -
FIGS. 10a-10b illustrate an exemplary design of the revolving peg as a safety feature. -
FIG. 11 illustrates an exemplary design of a flap as another safety feature. -
FIG. 12 illustrates different views of an assembled auto-injection device. -
FIG. 13 illustrates an exploded view of a second exemplary embodiment of the syringe in an auto-injection device. -
FIG. 14 illustrates an exploded view of a second exemplary embodiment of the assembled auto-injection device. -
FIGS. 15a-15d illustrates a third exemplary embodiment of the auto-injection device. -
FIG. 16 illustrates an exemplary wearable device comprising the auto-injection device. - Embodiments of the disclosure are described more fully hereinafter with reference to the accompanying drawings, in which preferred embodiments of the disclosure are shown. The various embodiments of the disclosure may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
- In referring to
FIG. 1 , an auto-injection device 100 is depicted as comprising aneedle 102, asyringe 104, a first set ofsprings 108 and a second set ofsprings 110. Theneedle 102 is connected to thesyringe 104 and in communication with thesyringe 104. In some embodiments, theneedle 102 and thesyringe 104 are coaxial. Thesyringe 104 comprises aplunger 106 and achamber 105 for storing an injection substance. The first set ofsprings 108 is coupled to thesyringe 104 and configured to push theneedle 102. The second set ofsprings 110 is coupled to theplunger 106 and configured to push theplunger 106. - In the embodiment shown in
FIG. 1 , the first set ofsprings 108 and the second set ofsprings 110 each comprise two springs. In other embodiments, each of the first and second set ofsprings FIG. 13 andFIG. 14 , each set comprises one spring. (More detailed description ofFIGS. 13 and 14 can be found in later sections.) - In referring to
FIG. 1 , the auto-injection device 100 is housed in acasing 120. Thecasing 120 comprises one ormore cantilevers 112 for supporting thesyringe 104 or pushing thesyringe 104 against the first set ofsprings 108 when the springs are in a compressed state. Each of the first and second set ofsprings FIG. 1 , both sets of springs are in a compressed state. Twoactivators injection device 100 further comprises a revolvingpeg 118, the functionality of which will be explained in detail inFIGS. 10a and 10 b.) - The first activator 114 (also see
FIG. 4 ) is configured to release the first set ofsprings 108 from the compressed state. When thefirst activator 114 is pushed inwards, i.e., towards thecasing 120, thestraight bars 115 press thecantilevers 112 outward. Thecantilevers 112 are pushed farther apart and the distance between the twocantilevers 112 increases. -
FIG. 2 depicts a state of thefirst activator 114 during the activation process. Thecantilevers 112 are bent towards thecasing 120 under the pressure of the straight bars 115. InFIG. 2 , theneedle 102 is thrust outside of thecasing 120 but thesyringe 104 has not fallen off thecantilevers 112 yet. As theactivator 114 continues to push upwards, the distance between the twocantilevers 112 increases until it is wider than the width of thesyringe 104 and thesyringe 104 moves off thecantilevers 112. The first set ofsprings 108 is released and pushes thesyringe 104 downward to thrust theneedle 102 out of thecasing 120 and into the injection site. - As the
syringe 104 moves downward, the second activator 116 (see alsoFIGS. 5a and 5b ) is activated to release the second set ofsprings 110 from a compressed state to a released state. The second set ofsprings 110 is coupled to theplunger 106 of thesyringe 104. As the second set ofsprings 110 is released, the springs push theplunger 106 down. Thechamber 105 underneath theplunger 106 stores the substance to be injected, e.g., epinephrine. As theplunger 106 moves downward, the substance is pushed into theneedle 102, which is in communication with thesyringe 104. Through theneedle 102, the substance is injected into a person. SeeFIG. 3 . -
FIG. 4 illustrates one exemplary embodiment in which thefirst activator 114 and thesecond activator 116 are activated in sequence. InFIG. 4 , thefirst activator 114 is shown to have been fully activated. Thefirst activator 114 is pressed inside thecasing 120. Thesyringe 104 has moved off thecantilevers 112 and the first set ofsprings 108 has pushed theneedle 102 partially outside of thecasing 120. Thesecond activator 116 however has not been activated and the second set ofsprings 110 is still in a compressed state. -
FIGS. 5a and 5b illustrate an exemplary embodiment of thesecond activator 116. Thesecond activator 116 comprises apin 502 and atube 504. Thetube 504 includes one or more cross-holes 506. Inside each cross-hole 506 sits aball 508. The size of theball 508 is larger than the thickness of the wall of thetube 504. Thesecond activator 116 is situated inside a T-shapedplunger 106 shown inFIG. 5 c. Theplunger 106 also comprises cross-holes 510 that can be aligned with thecross-holes 506 of thetube 504. When thepin 502 is fully inserted inside thetube 504, it pushes theballs 508 outward partially into thecross-holes 510 of theplunger 106. When thepin 502 is pulled up as shown inFIG. 5 b, under the pressure from theplunger 106, theballs 508 are pushed towards the inner side of thetube 504. When theballs 508 roll outside of the cross-holes 510 into thecross-holes 506, theplunger 106 is unblocked to move downward under the force of the compressed springs of thesecond set 110. As theplunger 106 moves downward, the stored substance, which may be medicinal or non-medicinal, is injected into the injection site through theneedle 102.FIG. 3 illustrates the configuration of the auto-injection device 100 after use. Thechamber 105 is empty. Thefirst set 108 and thesecond set 110 of the springs are relaxed. - As shown in
FIGS. 1-3 , thepin 502 of thesecond activator 116 is tied to two lugs (708 inFIG. 7 andFIG. 10a ) using a string orwire 130. When thesyringe 104 begins to move downward under the pressure from the first set ofsprings 108, thepin 502 is pulled up by the string orwire 130, activating the second set ofsprings 110. -
FIG. 6 illustrates different views of thesyringe 104. In the exploded view, the different parts of thesyringe 104 are depicted. At the top is thesecond activator 116, which is placed onto theplunger 106 through asyringe cap 608. Thesyringe cap 608 is configured with a hole at the center for receiving thesecond activator 106 and two protrusions at the bottom to plug into one end of the springs in thesecond set 110. The other end of the springs in thesecond set 110 rests on theflange 610 of theplunger 106. Aribbed plunger plate 604 made of rubber or plastic beneath theplunger 106 seals thechamber 105. Thesecond activator 116, thesyringe cap 608, the second set ofsprings 110, theplunger 106, theplunger plate 604, and theneedle 102 are then assembled into thesyringe shell 602. The front view, a side view, and a perspective view of the assembledsyringe 104 are depicted inFIG. 6 as well. - The assembled
syringe 104 and the first set ofsprings 108 can then be assembled into thecasing 120.FIGS. 7-11 illustrate the casing system.FIG. 12 illustrates different views of the assembled auto-injection device 100. -
FIG. 7 shows theframe 700 of anexemplary casing 120. Different views of theframe 700 are depicted to show different parts. In both the perspective view and the front view, thecantilevers 112 are shown as being affixed to two opposing interior sides of theframe 700. The bottom view shows ahole 702, configured to receive thefirst activator 114. The side view shows abump 704 on the outer side of the frame 700 (with another bump on the hidden side not shown). Thebumps 704 function to align theframe 700 with matching depressions on the internal side of the outer-cover 1202 (seeFIG. 12 , depressions not shown). This ensures that the frame 700 (with the auto-injection device 100 inset in it) does not slip off the outer-cover 1202 easily. Some force is required to remove theframe 700 from the outer-cover 1202 by unseating thebumps 704 from the depressions. The front view also shows two stubs orprotrusions 706 for holding the first set of springs 108 (seeFIG. 12 ), and twolugs 708 for tying the string orwire 130 that is used to suspend thesecond activator 116. -
FIG. 8 illustrates the perspective view, front and back view, and a side view of acover 800 for theframe 700. In some embodiments, thecover 800 can be placed on top of theframe 700 to seal thecasing 120. -
FIG. 9 illustrates a post-injection safety feature that can be installed on thecover 800. The safety feature is a revolvingsheath 900. The perspective (left image), front (top-right image) and bottom view (bottom-right image) of the revolvingsheath 900 are depicted inFIG. 9 . The revolvingsheath 900 can be attached to thecover 800 via theaperture 902 and can be open or closed. When in the closed position, the revolvingsheath 900 rests on thecover 800 to which it is attached. The revolvingsheath 900 can be swirled open after the auto-injection device 100 has been used for injection. In the open position, the revolvingsheath 900 covers theneedle 102 for safety protection. Theslot 904 on the side wall of the revolvingsheath 900 accommodates theneedle 102. A lock mechanism (shown inFIGS. 10a and 10b ) locks the revolvingsheath 900 in the open position so that the usedneedle 102 remains covered. - In one embodiment, the revolving
sheath 900 is attached to theframe 700 via a revolvingpeg 118 illustrated inFIGS. 10a -10 b. As shown inFIG. 10 a, the revolvingpeg 118 is the cylindrical peg located in the lower left corner of theframe 700. The revolvingpeg 118 comprises a D-shapedbutton 1002 at the top that matches the shape of theaperture 902 on thesheath 900 and allows the revolvingsheath 900 to be attached. The revolvingpeg 118 further comprises aslot 1004, which can be aligned with theslot 1006 located at the base of the revolvingpeg 118 through rotation. When the revolvingsheath 900 is pushed open, the revolvingpeg 118 is turned by the coupling force via the D-shapedbutton 1002. The revolvingpeg 118 includes aspring 1014 and a revolving key 1018, as shown inFIG. 10 b. The revolving key 1018 can be fitted into theslot 1004 when thespring 1014 is compressed. The revolvingpeg 118 rotates with the revolvingsheath 900, which also rotates the revolving key 1018 as the key 1018 is fitted inside theslot 1004. Once the twoslots spring 1014 pushes the key 1018 down so that the key 1018 engages theslot 1006. Because the height of the key 1018 is greater than that of theslot 1006, the key 1018 sits fully within theslot 1006 and partially within theslot 1004. This prevents relative rotation between theslot 1006 and the revolvingpeg 118, thus locking the revolvingsheath 900 in front of theneedle 102. -
FIG. 11 illustrates another safety feature. InFIG. 11 , the cantilevers 112 (only one is shown) stand against aflap 1122 of the outer-cover (1204 or 1202 shown inFIG. 12 ). When the auto-injection device 100 is stowed inside the outer-cover flaps 1122 jam thefirst activator 114 and prevents thefirst activator 114 from bending thecantilever 112. This safety feature ensures that the auto-injection device 100 will not activate until it is taken out of the outer-covers -
FIG. 12 shows different views of an assembled auto-injection device 100. On the left are four views of the assembled auto-injection device 100 enclosed in the outer-covers. Starting from the top left and going clockwise, the views are a side view, the front view, the bottom view, and a perspective view of theenclosed device 100. On the right is an exploded view of the assembled auto-injection device 100. The first set ofsprings 108, thesyringe 104, and thefirst activator 114 are assembled into the syringe shell (602, not labeled) before being fitted into theframe 700, with the twostubs 706 of theframe 700 being inserted into thesprings 108 and a string orwire 130 tying thesecond activator 116 to the lugs of the frame 700 (not shown). The revolvingsheath 900, thecover 800, and the revolving peg 118 (along with the revolvingkey 1018 and the revolving spring 1014) are then assembled onto theframe 700. The two outer-covers FIG. 11 , one or both of the two outer-covers more flaps 1122. When the auto-injection device 100 is stowed inside the outer-covers, theflaps 1122 are pressed against thecantilevers 112, preventing thecantilevers 112 from bending or moving outwardly so that thesyringe 104 does not fall off thecantilevers 112 by accident. -
FIG. 13 andFIG. 14 illustrate a second embodiment of thesyringe 104. Instead of using sets of two springs, the embodiment inFIGS. 13 and 14 uses one spring for each set. InFIG. 13 , thepin 502 is inserted into thetube 504. Along with the twoidentical balls 508, they form thesecond activator 116, which is placed onto thesecond spring 110, installed on top of theplunger 106 along with theplunger plate 604, and inserted into thesyringe shell 602 that also accommodates theneedle 102. After thesyringe 104 is assembled, it is then placed into aframe 1410, acover 1412, and out-covers injection device 100 as shown inFIG. 14 . -
FIG. 14 depicts an exploded view of the second embodiment of the auto-injection device 100. InFIG. 14 , the assembled syringe 104 (shown inFIG. 13 ) is inserted into afirst activator 114, along with afirst spring 108 and acap 1408. The assembled system is then encased by different parts of thecasing 120, e.g., 1410 and 1412. The encased auto-injection device 100 are covered by a top outer-cover piece 1402 and a bottom out-cover piece 1404. Similar to the out-covers shown inFIG. 12 , the out-covers first activator 114 and prevent the auto-injection device 100 from being activated when it is stowed inside the out-covers. - It is noted that the
frame 1410, shown inFIG. 14 as comprising two separate pieces, can in fact comprise one or multiple pieces. For instance, theframe 1410 may be an annular ring and thecantilevers 112 is a one-piece component within the annular ring. For another instance, theframe 1410 may comprise two or more arcs that can be made into one annular ring and each arc of theframe 1410 includes acantilever structure 112. -
FIGS. 15a-15d illustrate a third embodiment of the auto-injection device 100. In this embodiment, the auto-injection device 100 has a casing 120 (e.g.,frame 700 and cover 800) that changes shape by extending along the axis of theneedle 102 using a telescoping mechanism. In this embodiment, the casing comprises three separate components that together enclose the internal mechanisms. The set of activation spring(s) 108 begin compressed and pushes the rear section of thecasing 120 away from the tip of theneedle 102 once theouter cover 1402 is removed. Attached to the rear section of thecasing 120 are small snap-fit pieces that move parallel to the body of thedevice 100 within a confined space. The confined space compresses the snap-fit pieces such that they begin in a compressed state. - When the rear section of the
casing 120 reaches the end of its moving path, the snap-fit pieces (1502 inFIGS. 15a-15d ) exit the confined space and are allowed to expand. In their expanded state, the snap-fit pieces cannot return to the confined space, so the rear section of thecasing 120 cannot be pushed back towards the tip of theneedle 102. After the body has expanded, the set of activation springs 108 remain in a partially compressed state. This ensures that they can push theneedle 102 out of thedevice 100 upon activation. -
FIGS. 15a-15b show the mid-plane views of the auto-injection device 100 in a compressed state.FIG. 15a is a mid-plane view of thesprings 108 being compressed.FIG. 15b is a mid-plane view of the snap-fit pieces in a compressed position. -
FIGS. 15c-15d show the mid-plane views of the auto-injection device 100 in an extended state.FIG. 15c is a mid-plane view of thesprings 108 that has partially expanded.FIG. 15d is a mid-plane view of the snap-fit pieces. InFIG. 15 d, the snap-fit pieces 1502 are in an extended position that prevents them from moving back. Acap 1504 of the case moves outwards to complete the telescoping action. -
FIG. 16 illustrates an embodiment of a wearable auto-injection device 100. In some embodiments, the assembled auto-injection device 100 is light and compact and made in the shape of a watch. The out-covers (1202 and 1204 inFIG. 12 and 1402 and 1404 inFIG. 14 ) are fitted with lugs to accommodatestraps 1602 so that the auto-injection device 100 can be worn like a watch. The wrist-mounteddevice 100 inFIG. 16 can be carried by a patient for emergency use. In other embodiments, the out-covers can be made to resemble a piece of jewelry or toy. - The auto-
injection devices 100 disclosed herein have many applications, medical or non-medical. The size of thechamber 105 in the auto-injection device 100 can be manufactured in accordance with the requirement of each application. In some applications, the size of thechamber 105 can be made fairly standard. In other applications, the size of thechamber 105 may be personalized. As mentioned in the background section, the auto-injection device 100 is useful in anaphylaxis and hyperglycemia emergency situations. The auto-injection device 100 can be useful in opioid overdose emergencies as well. Indeed, in many life-threatening situations, auto-injection devices disclosed herein can save lives by providing timely relief of the symptoms. - Although the disclosure is illustrated and described herein with reference to specific embodiments, the disclosure is not intended to be limited to the details shown. Rather, various modifications may be made in the details within the scope and range of equivalents of the claims and without departing from the disclosure.
Claims (16)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US17/549,120 US20220096752A1 (en) | 2018-03-22 | 2021-12-13 | Auto-injection device |
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US201862646518P | 2018-03-22 | 2018-03-22 | |
US16/607,323 US20200376199A1 (en) | 2018-03-22 | 2019-03-21 | Auto-injection device |
PCT/US2019/023417 WO2019183384A1 (en) | 2018-03-22 | 2019-03-21 | Auto-injection device |
US17/090,236 US11229744B2 (en) | 2018-03-22 | 2020-11-05 | Auto-injection device |
US17/549,120 US20220096752A1 (en) | 2018-03-22 | 2021-12-13 | Auto-injection device |
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US17/090,236 Continuation US11229744B2 (en) | 2018-03-22 | 2020-11-05 | Auto-injection device |
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US17/090,236 Active US11229744B2 (en) | 2018-03-22 | 2020-11-05 | Auto-injection device |
US17/549,120 Abandoned US20220096752A1 (en) | 2018-03-22 | 2021-12-13 | Auto-injection device |
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US17/090,236 Active US11229744B2 (en) | 2018-03-22 | 2020-11-05 | Auto-injection device |
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TWI723813B (en) * | 2020-03-20 | 2021-04-01 | 國立勤益科技大學 | Wearable injection device |
Citations (4)
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WO2004060445A2 (en) * | 2002-12-27 | 2004-07-22 | Medsolve Technologies, L.L.C. | Safety system for syringe |
US20080289984A1 (en) * | 2007-04-18 | 2008-11-27 | Raven Sophie R | Container for an automatic injector |
US20140046259A1 (en) * | 2010-12-02 | 2014-02-13 | Oval Medical Technologies Limited | Delivery mechanism for an autoinjector |
US20180361078A1 (en) * | 2015-12-11 | 2018-12-20 | Oval Medical Technologies Limited | Autoinjector with retracting needle |
Family Cites Families (10)
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US6979316B1 (en) * | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
US20070100288A1 (en) * | 2003-06-05 | 2007-05-03 | University Of Florida Research Foundation, Inc. | Auto-injection devices and methods for intramuscular administration of medications |
WO2011101382A1 (en) * | 2010-02-22 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Auto - injector with needle shroud and needle protection cap |
RU2012138044A (en) * | 2010-03-25 | 2014-04-27 | Нью Инджекшн Системз Лтд | SPRAYER |
EP2438940A1 (en) * | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Auto injector with a torsion spring |
EP2489380A1 (en) * | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Injection device |
US20140058333A1 (en) * | 2011-04-21 | 2014-02-27 | Sanofi-Aventis Deutschland Gmbh | Medicated module with automatic reservoir engagement and lock mechanism |
JP6133873B2 (en) * | 2011-09-09 | 2017-05-24 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Automatic syringe for epinephrine injection |
NL2013654B1 (en) * | 2014-10-20 | 2016-08-11 | Helène Tamara Witteman Amber | Portable injection device for portable attachment to a body part, for injecting a drug through the skin of the body part in a wearable condition. |
WO2019071129A1 (en) * | 2017-10-05 | 2019-04-11 | Pirouette Medical LLC | Protective case for an auto-injector |
-
2019
- 2019-03-21 WO PCT/US2019/023417 patent/WO2019183384A1/en active Application Filing
- 2019-03-21 US US16/607,323 patent/US20200376199A1/en not_active Abandoned
- 2019-03-21 EP EP19770960.3A patent/EP3768357A4/en not_active Withdrawn
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2020
- 2020-11-05 US US17/090,236 patent/US11229744B2/en active Active
-
2021
- 2021-12-13 US US17/549,120 patent/US20220096752A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004060445A2 (en) * | 2002-12-27 | 2004-07-22 | Medsolve Technologies, L.L.C. | Safety system for syringe |
US20080289984A1 (en) * | 2007-04-18 | 2008-11-27 | Raven Sophie R | Container for an automatic injector |
US20140046259A1 (en) * | 2010-12-02 | 2014-02-13 | Oval Medical Technologies Limited | Delivery mechanism for an autoinjector |
US20180361078A1 (en) * | 2015-12-11 | 2018-12-20 | Oval Medical Technologies Limited | Autoinjector with retracting needle |
Also Published As
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WO2019183384A1 (en) | 2019-09-26 |
US11229744B2 (en) | 2022-01-25 |
EP3768357A1 (en) | 2021-01-27 |
US20210052812A1 (en) | 2021-02-25 |
US20200376199A1 (en) | 2020-12-03 |
EP3768357A4 (en) | 2022-01-05 |
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