US20210401699A1 - Oral Care Compositions and Methods for Increasing Stability of the Same - Google Patents
Oral Care Compositions and Methods for Increasing Stability of the Same Download PDFInfo
- Publication number
- US20210401699A1 US20210401699A1 US17/472,252 US202117472252A US2021401699A1 US 20210401699 A1 US20210401699 A1 US 20210401699A1 US 202117472252 A US202117472252 A US 202117472252A US 2021401699 A1 US2021401699 A1 US 2021401699A1
- Authority
- US
- United States
- Prior art keywords
- weight
- oral care
- care composition
- hydrogen peroxide
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 150000002432 hydroperoxides Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- HPGPEWYJWRWDTP-UHFFFAOYSA-N lithium peroxide Chemical compound [Li+].[Li+].[O-][O-] HPGPEWYJWRWDTP-UHFFFAOYSA-N 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229960004995 magnesium peroxide Drugs 0.000 description 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 description 1
- 229960003987 melatonin Drugs 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 229960001245 olaflur Drugs 0.000 description 1
- ZVVSSOQAYNYNPP-UHFFFAOYSA-N olaflur Chemical compound F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO ZVVSSOQAYNYNPP-UHFFFAOYSA-N 0.000 description 1
- 150000004967 organic peroxy acids Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229940045916 polymetaphosphate Drugs 0.000 description 1
- ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Chemical compound O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 235000002639 sodium chloride Nutrition 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 229940045872 sodium percarbonate Drugs 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- 229940045919 sodium polymetaphosphate Drugs 0.000 description 1
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 description 1
- FWFUWXVFYKCSQA-UHFFFAOYSA-M sodium;2-methyl-2-(prop-2-enoylamino)propane-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)CC(C)(C)NC(=O)C=C FWFUWXVFYKCSQA-UHFFFAOYSA-M 0.000 description 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical class [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940085658 zinc citrate trihydrate Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
- A61K8/8182—Copolymers of vinyl-pyrrolidones. Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
- A61K2800/31—Anhydrous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
Definitions
- Conventional oral care products or compositions thereof including whitening agents are often utilized to whiten teeth.
- conventional toothpastes including peroxides e.g., hydrogen peroxide
- peroxides e.g., hydrogen peroxide
- the peroxides are often unstable and subject to degradation.
- the peroxides are often incorporated into non-aqueous oral care products and/or compositions to aid in stabilizing the peroxides.
- non-aqueous oral care compositions such as non-aqueous toothpastes, have proven to be effective for stabilizing the peroxides, gelling agents and/or thickeners that are compatible with propylene glycol are limited.
- non-aqueous oral care compositions incorporating hydrogen peroxide often utilize a limited selection of conventional thickeners to facilitate the thickening and/or gelling of the oral care compositions.
- the non-aqueous oral care compositions often incorporate fumed silica and/or cross-linked polymers (e.g., cross-linked PVP) to thicken and/or gel the oral care compositions.
- the conventional thickeners are not able to form networks with one another. As such, solids contained in the oral care compositions may often settle, thereby resulting in phase separation within the oral care com positions.
- anhydrous oral care composition including an orally acceptable vehicle, a thickening system, and a whitening agent.
- the orally acceptable vehicle may include propylene glycol
- the thickening system may include an polymeric thickener that may be a copolymer of 2-acrylamidomethylpropanesulphonic acid or a salt thereof.
- the polymeric thickener may be a block copolymer.
- the polymeric thickener may include a block copolymer of a first monomer and a second monomer.
- the first monomer may include the 2-acrylamidomethylpropanesulphonic acid or a salt thereof
- the second monomer may include a vinyl monomer having a nitrogenous side chain.
- the vinyl monomer may be or include at least one of a methacrylic acid, a methacrylate, a methacrylamide, a methacrylate salt, a vinyl pyrrolidone, and combinations thereof.
- the first monomer may be an ammonium salt of 2-acrylamidomethylpropanesulphonic acid.
- the second monomer may include a vinyl monomer having an amide functional group.
- the second monomer may be N-vinylpyrrolidone.
- the polymeric thickener may be a copolymer of an ammonium salt of 2-acrylamidomethylpropanesulphonic acid and a N-vinylpyrrolidone.
- the thickening system may include or consist of a copolymer of an ammonium salt of 2-acrylamidomethylpropanesulphonic acid and a N-vinylpyrrolidone.
- the anhydrous oral care composition may be substantially free of fluoride.
- the anhydrous oral care composition may not include or be free of fumed silica and cross-linked polyvinylpyrrolidone.
- the oral care composition may include less than 5.0 weight % water, preferably less than 1.0 weight % water, and more preferably less than 0.1 weight % water.
- the whitening agent may include a cross-linked polyvinylpyrrolidone (PVP) hydrogen peroxide complex.
- PVP polyvinylpyrrolidone
- the foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing a method for preventing phase separation in an anhydrous oral care composition.
- the method may include contacting an orally acceptable vehicle including propylene glycol and a whitening agent with one another to form the oral care composition, and contacting the anhydrous oral care composition with a polymeric thickener.
- the polymeric thickener may include a block copolymer of a first monomer and a second monomer, wherein the first monomer may include an acrylamide having a sulfonic group, and wherein the second monomer may include a vinyl monomer having a nitrogenous side chain, preferably, the polymeric thickener is a copolymer of an ammonium salt of 2-acrylamidomethylpropanesulphonic acid and a N-vinylpyrrolidone
- the present inventors have surprisingly and unexpectedly discovered that polymers or polymeric thickeners effectively prevent phase separation in oral care compositions incorporating whitening agents (e.g., peroxides).
- the polymeric thickener may be or include a copolymer of a first monomer, such as a 2-acrylamidomethylpropanesulphonic acid or a salt thereof, and a second monomer, such as a methacrylic acid, methacrylates, methacrylamides, methacrylate salts, and vinylpyrrolidone, effectively prevents phase separation in oral care compositions incorporating whitening agents (e.g., peroxides).
- the present inventors have surprisingly and unexpectedly discovered that a block copolymer of a 2-acrylamidomethylpropanesulphonic acid salt and N-vinylpyrrolidone effectively prevents phase separation in non-aqueous oral care compositions incorporating whitening agents (e.g., peroxides).
- whitening agents e.g., peroxides
- the block copolymer of a 2-acrylamidomethylpropanesulphonic acid salt and N-vinylpyrrolidone is an effective thickener for non-aqueous oral care compositions.
- the present inventors have further surprisingly and unexpectedly discovered that the block copolymer of a 2-acrylamidomethylpropanesulphonic acid salt and N-vinylpyrrolidone is compatible with and/or maintains stability of the whitening agents of the oral care compositions. It was further surprisingly and unexpectedly discovered that the oral care composition exhibited stability (e.g., no phase separation) for at least two months when exposed to accelerated aging conditions.
- compositions disclosed herein may be or include an oral care product and/or an oral care composition thereof.
- the oral care composition may be a non-aqueous oral care composition, such as a non-aqueous dentifrice or toothpaste.
- the oral care composition may include an orally acceptable vehicle, such as propylene glycol, one or more whitening agents, and a thickener.
- the thickener of the oral care composition does not include fumed silica and/or a cross-linked polymer, such as cross-linked polyvinylpyrrolidone.
- the oral care composition prior to use may be anhydrous.
- the oral care composition may be free or substantially free of water.
- “free” or “substantially free” may refer to a composition that contains less than 5.0 weight %, less than 3.0 weight %, less than 1.0 weight %, less than 0.1 weight %, less than 0.05 weight %, less than 0.01 weight %, less than 0.005 weight %, or less than 0.0001 weight % based on a total weight of the oral care composition.
- the oral care composition prior to use may have a “low water content”.
- “low water content” may refer to a composition that contains greater than about 5 weight % and less than about 7 weight % or less than about 10 weight %.
- the oral care composition may form at least a portion of or be used in one or more oral care products.
- Illustrative oral care products may include, but are not limited to, a toothpaste (dentifrice), a prophylactic paste, a tooth powder, a tooth polish, a tooth gel (e.g., a whitening gel), a chewing gum, a lozenge, a mouthwash, a whitening strip, a paint-on gel, varnish, veneer, and tube, syringe or dental tray comprising a gel or paste, or a gel or paste coated on an application support such as dental floss or a toothbrush (e.g., a manual, electric, sound, a combination thereof or ultrasound toothbrush).
- the oral care composition may form at least a portion of or be used with a toothpaste.
- the oral care composition may typically be a gel of the toothpaste, or a whitening gel to be combined with the toothpaste.
- the oral care composition may include or be combined with an orally acceptable vehicle to form the oral care product (e.g., the toothpaste).
- the orally acceptable vehicle may be or include propylene glycol.
- the orally acceptable vehicle may include one or more humectants.
- Illustrative humectants may be or include, but are not limited to, glycerin, propylene glycol, and combinations thereof.
- the orally acceptable vehicle may be or includes, but is not limited to, propylene glycol.
- the propylene glycol may be present in an amount of from 20 weight % to about 75 weight %, based on a total weight of the oral care composition.
- the propylene glycol may be present in an amount of from about 20 weight %, about 25 weight %, about 30 weight %, about 35 weight %, about 40 weight %, or about 45 weight % to about 50 weight %, about 55 weight %, about 60 weight %, about 65 weight %, about 70 weight %, or about 75 weight %.
- the propylene glycol may be present in an amount of from about 20 weight % to about 75 weight %, about 25 weight % to about 70 weight %, about 30 weight % to about 65 weight %, about 35 weight % to about 60 weight %, about 40 weight % to about 55 weight %, or about 45 weight % to about 50 weight %.
- the propylene glycol may be present in an amount of about 45 weight % to about 50 weight %, or in an amount of about 60 weight % to about 70 weight %.
- the oral care composition may include one or more whitening agents.
- the whitening agents may be or include, but are not limited to, hydrogen peroxide or one or more sources of hydrogen peroxide.
- the whitening agents may be hydrogen peroxide and/or hydrogen peroxide releasing substances.
- the one or more sources of hydrogen peroxide may be or include any compound or material configured to release hydrogen peroxide.
- the whitening agents include, but are not limited to, solid whitening agents and bound whitening agents which are substantially anhydrous oxygen generating compounds.
- Solid whitening agents useful herein include peroxides, persulfate.
- Exemplary peroxide phases include hydroperoxides, hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, pharmaceutically-acceptable salts thereof, and mixtures thereof.
- Peroxides of alkali and alkaline earth metals include, but are not limited to, lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof.
- Organic peroxy compounds include, but are not limited to, urea peroxide, glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof.
- Peroxy acids and their salts include, but are not limited to, organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as and perborate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof.
- Preferred solid peroxides are sodium perborate, urea peroxide, and mixtures thereof.
- the whitening agents may be preferably bound.
- peroxide may be bound to a polymer such as PVP (poly(N-vinylpyrrolidone).
- PVP poly(N-vinylpyrrolidone).
- Suitable PVP complexes are disclosed, for example, in U.S. Pat. No. 5,122,370, the contents of which are incorporated herein by reference.
- the sources of hydrogen peroxide or whitening agents may also be or include, but are not limited to, PEROXYDONETM XL 10 complex or POLYPLASDONE® XL 10F, which are commercially available from Ashland Inc. of Covington, Ky..
- the source of hydrogen peroxide includes a cross-linked PVP hydrogen peroxide complex.
- the amount or concentration of the source of hydrogen peroxide may vary widely.
- the source of hydrogen peroxide may be present in an amount that provides a concentration of hydrogen peroxide of less than or equal to 4 weight %, less than or equal to 3.5 weight %, less than or equal to 3 weight %, less than or equal to 2.5 weight less than or equal to 2 weight %, or less than or equal to 1.5 weight %, based on a total weight of the oral care composition.
- the source of hydrogen peroxide may be present in an amount greater than or equal to 1 weight % and less than or equal to 30 weight %, based on a total weight of the oral care composition.
- the source of hydrogen peroxide may be present in an amount of from about 1 weight %, about 3 weight %, about 5 weight %, about 7 weight %, about 9 weight %, about 11 weight %, about 13 weight %, or about 15 weight % to about 17 weight %, about 19 weight %, about 21 weight %, about 22 weight %, about 23 weight %, about 25 weight %, about 27 weight %, about 29 weight %, or about 30 weight %.
- the source of hydrogen peroxide may be present in an amount of from about 1 weight % to about 30 weight %, about 3 weight %, about 29 weight %, about 5 weight % to about 27 weight %, about 7 weight % to about 25 weight %, about 9 weight % to about 23 weight %, about 11 weight % to about 21 weight %, about 13 weight % to about 19 weight %, or about 15 weight % to about 17 weight %.
- the source of hydrogen peroxide is a cross-linked PVP complexed with hydrogen peroxide, and is present in an amount of from about 15 weight % to about 17 weight %, preferably about 16 weight % to about 17 weight %, and more preferably about 16.5 weight %.
- the source of hydrogen peroxide is a cross-linked PVP complexed with hydrogen peroxide, and is present in an amount of from about 20 weight % to about 30 weight %, preferably about 21 weight % to about 25 weight %, and more preferably about 22 weight %.
- the oral care composition may include a thickening system having one or more thickeners.
- the one or more thickeners may be any orally acceptable thickener or thickening agent configured to at least partially form a network and thereby prevent phase separation in the oral care composition.
- Illustrative thickeners may be or include a polymeric thickener, such as a copolymer of at least two monomers, where a first monomer may be an acrylamide having a sulfonic or sulphonic group, and a second monomer may be a vinyl monomer having a nitrogenous side chain.
- Illustrative vinyl monomers may be or include, but are not limited to, methacrylic acid, methacrylates, methacrylamides, methacrylate salts, vinyl pyrrolidone, and the like, and combinations thereof.
- the thickener may be or include a copolymer of 2-acrylamidomethylpropanesulphonic acid or a salt thereof, such as an ammonium or sodium salt, and a vinyl monomer having a nitrogenous cyclic side chain or a vinyl monomer having an amide functional group, such as N-vinylpyrrolidone.
- the thickener may be a copolymer of the ammonium salt of 2-acrylamidomethylpropanesulphonic acid and N-vinylpyrrolidone, which is commercially available as ARISTOFLEX® AVC from Clariant International Ltd. of Charlotte, N.C.
- the block copolymer thickener may have the INCI name ammonium acryloyldimethyltaurate/VP copolymer or correspond to the GAS reference number 335383-60-3.
- Another preferred thickener may be a block copolymer of the sodium salt of 2-acrylamidomethylpropanesulphonic acid and N-vinylpyrrolidone, which is commercially available as ARISTOFLEX® AVS from Clariant International Ltd.
- the polymeric thickener may be ARISTOFLEX® HMB, ARISTOFLEX® BLV, and/or ARISTOFLEX® TAC, which are commercially available from Clariant International Ltd.
- the polymeric thickener may be or include polyacrylate crosspolymer-6, which is commercially available as SEPIMAXTM ZEN from SEPPIC S.A., a subsidiary of the Air Liquide group, Puteaux Cedex, France.
- the oral care composition may be free or substantially free of fumed silica.
- the oral care composition prior to use may be free or substantially free of cross-linked PVP.
- the oral care composition prior to use may include a cross-linked PVP complexed with hydrogen peroxide as a source of hydrogen peroxide, but may also be free or substantially free of the cross-linked PVP.
- the oral care composition may be free or substantially free of both fumed silica and cross-linked PVP prior to use.
- the oral care composition may include fumed silica and cross-linked PVP.
- the amount or concentration of the thickening system or the thickener thereof in the oral care composition may vary widely
- the amount of the thickener present in the oral care composition may be greater than or equal to 0.1 weight % and less than or equal to 1.0 weight %, based on a total weight of the oral care composition.
- the amount of the thickener present in the oral care composition may be from about 0.1 weight %, about 0.2 weight %, about 0.3 weight %, about 0.4 weight %, or about 0.5 weight % to about 0.6 weight %, about 0.7 weight %, about 0.8 weight %, about 0.9 weight %, or about 1.0 weight %.
- the amount of the thickener present in the oral care composition may be from about 0.1 weight % to about 1.0 weight %, about 0.2 weight % to about 0.9 weight %, about 0.3 weight % to about 0.8 weight %, about 0.4 weight % to about 0.7 weight %, or about 0.5 weight % to about 0.6 weight %. In some embodiments, the amount of the thickener present in the oral care composition may be from about 0.4 weight % to about 0.6 weight %, optionally about 0.4 weight % or about 0.55 weight %.
- the amount of the thickener present in the oral care composition may be greater than 0 weight % and less than or equal to 20 weight %, based on a total weight of the oral care composition.
- the amount of the thickener present in the oral care composition may be greater than 0 weight % and less than or equal to 20 weight %, less than or equal to 18 weight %, less than or equal to 16 weight %, less than or equal to 14 weight %, less than or equal to 12 weight %; less than or equal to 10 weight %, less than or equal to 8 weight %, less than or equal to 6 weight %, less than or equal to 5 weight %, less than or equal to 4 weight %, less than or equal to 3 weight %, less than or equal to 2 weight %, less than or equal to 1.8 weight %, less than or equal to 1.6 weight %, less than or equal to 1.4 weight %, less than or equal to 1.2. weight %, less than or equal to 1.0 weight %, less than or
- the oral care composition may include additional and/or optional thickeners.
- additional or optional thickeners may be or include, but are not limited to, carbomers (e.g., carboxyvinyl polymers), carrageenans (e.g., Irish moss, carrageenan, iota-carrageenan, etc.), high molecular weight polyethylene glycols (e.g., CARBOWAX®, which is commercially available from The Dow Chemical Company of Midland, Mich.), cellulosic polymers, hydroxyethylcellulose, carboxymethylcellulose, and salts thereof (e.g., CMC sodium), natural gums (e.g., karaya, xanthan, gum arabic, and tragacanth), colloidal magnesium aluminum silicate, and the like, and mixtures or combinations thereof.
- carbomers e.g., carboxyvinyl polymers
- carrageenans e.g., Irish moss, carrageenan, iota-car
- the oral care composition may include one or more polymers or polymer additives.
- the oral care composition may include one or more block co-polymers of polyethylene glycol and polyethylene glycol (e.g., molecular weight of at least 5000 Da), polypropylene glycol and polyethylene glycol, and the like, and combinations thereof.
- the oral care composition includes a block co-polymer of ethylene oxide and propylene oxide represented by the formula (1),
- the block co-polymer of ethylene oxide and propylene oxide may have an average molecular weight greater than or equal to about 5,000 Da and less than or equal to about 20,000 Da.
- the molecular weight of the block co-polymer of ethylene oxide and propylene oxide may be from about 8,000 Da to about 13,000 Da.
- the molecular weight of the block co-polymer of ethylene oxide and propylene oxide may be from about 9,800 Da or about 10,000 Da.
- the molecular weight of the block co-polymer of ethylene oxide and propylene oxide may be from about 8,000 Da to about 10,000 Da.
- the oral care composition does not include a block co-polymer of ethylene oxide and propylene oxide having a molecular weight less than 5,000 Da.
- at least 99.5%, at least 99.0%, or at least 99.9% of the block co-polymer of ethylene oxide and propylene oxide present in the oral care composition has a molecular weight greater than or equal to 5,000 Da.
- the polymers or polymer additives, if included in the composition may be or include PLURAFLO® L4370 and PLURAFLO® L1220, both of which are commercially available from B A SF of Wyandotte, Mich.
- the amount or concentration of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may vary widely. In at least one implementation, the amount of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may be from about 5 weight % to about 10 weight %.
- the amount of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may be from about 5.0 weight %, about 5.5 weight %, about 6.0 weight %, about 6.5 weight %, about 7.0 weight %, or about 7.5 weight % to about 8.0 weight %, about 8.5 weight %, about 9.0 weight %, about 9.5 weight %, or about 10.0 weight %.
- the amount of the polymers or polymer additives present in the oral care composition may be from about 5.0 weight % to about 10.0 weight %, about 5.5 weight % to about 9.5 weight %, about 6.0 weight % to about 9.0 weight %, about 6.5 weight % to about 8.5 weight %, or about 7.0 weight % to about 8.0 weight %. In another implementation, the amount of the polymer or polymer additives present in the oral care composition may be from about 5 weight % to about 15 weight % based on a total weight of the oral care composition.
- the amount of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may be from about 5.0 weight %, about 5.5 weight %, about 6.0 weight %, about 6.5 weight %, about 7.0 weight %, about 7.5 weight %, about 8.0 weight %, about 8.5 weight %, about 9.0 weight %, about 9.5 weight %, or about 10.0 weight % to about 10.5 weight %, about 11.0 weight %, about 11.5 weight %, about 12.0 weight %, about 12.5 weight %, about 13.0 weight %, about 13.5 weight %, about 14.0 weight %, about 14.5 weight %, or about 15.0 weight %.
- the polymers or polymer additives may be or include PLURACARE® L1220, which is commercially available from BASF of Wyandotte, Mich.
- the polymer or polymer additive may be or include polyethylene glycol (e.g., about 400-800 Da, or about 600 Da).
- the polymer or polymer additive may be or include a low or medium molecular weight polyethylene glycol having a molecular weight greater than or equal to about 400 Da and less than or equal to about 1000 Da.
- the polymer or polymer additive may be or include PEG 400, PEG 600, PEG 800, PEG 100, and the like, and mixtures or combinations thereof.
- the oral care composition may include a stabilizing amount of an additional linear PVP.
- the oral care composition may include a surfactant or surfactant system including one or more surfactants.
- the surfactant may be configured to at least partially aid or facilitate the mixing or contact between one or more components of the oral care composition.
- the surfactant may aid the mixing or facilitate contact between a hydrophobic component/phase and a hydrophilic component/phase of the oral care composition.
- the surfactants may be or include anionic, nonionic, cationic, amphoteric surfactants, or combinations thereof.
- Illustrative surfactants may be or include, but are not limited to, water-soluble salts of C 8-20 alkyl sulfates, sulfonated monoglycerides of C 8-20 fatty acids, sarcosinates, taurates, sodium lauryl sulfate, sodium cocoyl monoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl isoethionate, sodium laureth carboxylate, and sodium dodecyl benzenesulfonate, and cocoamidopropyl betaine.
- Illustrative surfactants or surface active agents may also be or include, but are not limited to, PLURONIC® L35, PLURONIC® L43, PLURONIC® L64, PLURONIC® L10, PLURONIC® L44, PLURONIC® L62, PLURONIC® 10R5, PLURONIC® 17R4, PLURONIC® L25R4, PLURONIC® P84, PLURONIC P65, PLURONIC® P104, PLURONIC® P105, and the like, and combinations thereof, which are commercially available from BASF of Mount Olive, N.J.
- the surfactant is or includes a polyethylene glycol)-block-poly(propylene glycol)-block-polyethylene glycol) or PEG-PPG-PEG (PLURONIC® L-35).
- the amount of the surfactants present in the oral care composition may vary widely.
- the amount of one or more surfactants present in the oral care composition may be greater than or equal to 0.0 weight % and less than or equal to 10.0 weight %, based on a total weight of the oral care composition.
- the amount of the surfactant present in the oral care composition may be from about 0.0 weight %, about 1 weight %, about 2 weight %, about 3 weight %, about 4 weight %, or about 4.5 weight % to about 5.5 weight %, about 6 weight %, about 7 weight %, about 8 weight %, about 9 weight %, or about 10 weight %, based on a total weight of the oral care composition.
- the amount of the surfactant present in the oral care composition may be from about 0.0 weight % to about 10 weight %, about 1 weight % to about 9 weight %, about 2 weight % to about 8 weight %, about 3 weight % to about 7 weight %, about 4 weight % to about 6 weight %, or about 4.5 weight % to about 5.5 weight %, based on a total weight of the oral care composition.
- the amount of the surfactant present in the oral care composition may be from about 4 weight % to about 6 weight %, more preferably about 4.5 weight % to about 5.5 weight %, more preferably about 5.0 weight %, based on a total weight of the oral care composition.
- the oral care composition may include one or more abrasives or dental abrasive agents.
- abrasive may also refer to materials commonly referred to as “polishing agents”.
- any suitable orally acceptable abrasive may be used, but preferably, the type, fineness (particle size) and amount of the abrasives should be selected such that tooth enamel is not excessively abraded in normal use of the oral care composition.
- Suitable abrasives include without limitation silica, for example in the form of silica gel, hydrated silica or precipitated silica, alumina, insoluble phosphates, calcium carbonate, resinous abrasives such as urea-formaldehyde condensation products and the like.
- insoluble phosphates useful as abrasives are orthophosphates, polymetaphosphates and pyrophosphates.
- Illustrative examples are dicalcium orthophosphate dihydrate, calcium pyrophosphate, (3-calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate and insoluble sodium polymetaphosphate.
- Average particle size of an abrasive is generally about 0.1 to about 30 ⁇ m, for example about 1 to about 20 ⁇ m or about 5 to about 15 ⁇ m.
- the abrasive may be maintained in the dentifrice of the oral care composition.
- the amount or concentration of the abrasives may be from about 5 wt % to about 40 wt %, based on a total weight of the oral care composition.
- the amount of the abrasives present in the oral care composition may be from about 5.0 wt %, about 5.5 wt %, about 6.0 wt %, about 6.5 wt %, about 7.0 wt %, about 7.5 wt %, about 8.0 wt %, about 8.5 wt %, about 9.0 wt %, about 9.5 wt %, about 10.0 wt %, about 10.5 wt %, about 11.0 wt %, about 11.5 wt %, or about 12.0 wt % to about 12.5 wt %, about 13.0 wt %, about 13.5 wt %, about 14.0 wt %, about 14.5 wt %, about 15.0
- the amount of the abrasives present in the oral care composition may be from about 5 wt %, about 10 wt %, about 15 wt %, or about 20 wt % to about 25 wt %, about 30 wt %, about 35 wt %, or about 40 wt %.
- the oral care products and/or the oral care composition thereof may be free or substantially free of fluoride (e.g., soluble fluoride salts).
- the oral care products and/or the oral care composition thereof may further include fluoride, such as one or more fluoride ion sources (e.g., soluble fluoride salts).
- fluoride ion-yielding materials may be employed as sources of soluble fluoride. Examples of suitable fluoride ion-yielding materials may be found in U.S. Pat. No. 3,5.35,421 to Briner et al., U.S. Pat. No. 4,885,155 to Parran, Jr. et al., and U.S. Pat.
- Illustrative fluoride ion sources include, but are not limited to, fluoride, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, fluorosilicate salts, such as sodium fluorosilicate and ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
- the fluoride ion source includes sodium fluoride.
- the amount of the fluoride ion source in the oral care composition may be less than 0.08 wt %, less than 0.07 wt %, less than 0.06 wt %, less than 0.05 wt %, or less than 0.04 wt %.
- the amount of the fluoride ion source may be about 0.05 wt %.
- the fluoride ion source is present in an amount to provide a total of about 100 to about 20,000 ppm, about 200 to about 5,000 ppm, or about 500 to about 2,500 ppm, fluoride ions.
- the oral care products and/or the oral care composition thereof may include other additional ingredients/components.
- the oral care products and/or the oral care composition thereof may include anti-caries agents, desensitizing agents, viscosity modifiers, diluents, pH modifying agents, humectants, mouth feel agents, sweetening agents, flavor agents, colorants, preservatives, and the like, and combinations and mixtures thereof.
- the compositions described herein are substantially free of volatile flavoring agents.
- the compositions described herein are completely free of volatile flavoring agents. It should further be appreciated by one having ordinary skill in the art that while general attributes of each of the above categories of materials may differ, there may be some common attributes and any given material may serve multiple purposes within two or more of such categories of materials.
- the additional ingredients/components may include one or more active materials configured to prevent and/or treat one or more conditions and/or disorders of the oral cavity.
- the one or more active materials may be configured to prevent and/or treat one or more conditions and/or disorders of hard and/or soft tissue of the oral cavity.
- the active materials may also be configured to prevent and/or treat one or more physiological disorders and/or conditions, and/or provide a cosmetic benefit to the oral cavity.
- the oral care products or the oral care composition thereof may include an anticalculus agent.
- anticalculus agents may not be compatible with some oral care composition, however, implementations of the present disclosure may incorporate anticalculus agents and the oral care composition into a single phase oral care product.
- Illustrative anticalculus agents may include, but are not limited to, phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates.
- the anticalculus agents includes tetrasodium pyrophosphate (TSPP), sodium tripolyphosphate (STPP), or a combination thereof.
- the oral care products or the oral care composition thereof may include an antioxidant.
- Any orally acceptable antioxidant may be used, including, but not limited to, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenois, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and the like, and combinations and mixtures thereof.
- compositions described herein are orally acceptable.
- the expression “orally acceptable” may define an ingredient that is present in a composition as described in an amount and form that does not render the composition unsafe for use in the oral cavity.
- the present disclosure may provide methods for preventing phase separation in an oral care product or the oral care composition thereof that incorporate whitening agents (e.g., peroxides).
- the method may include contacting the oral care composition with a polymeric thickener having a first monomer, such as a 2-acrylamidomethylpropanesulphonic acid or a salt thereof, and a second monomer, such as a methacrylic acid, methacrylates, methacrylamides, methacrylate salts, and vinylpyrrolidone.
- the oral care composition may be a non-aqueous or propylene glycol based oral care composition.
- the method may include not combining at least one other thickener, such as fumed silica and cross-linked polyvinylpyrrolidone.
- the method may also include forming a intermolecular bonding network between a plurality of the polymers of the polymeric thickener to prevent phase separation.
- the method may include preventing phase separation under accelerated aging conditions, for example at a temperature from about 40° C. to about 50° C.
- the method may include preventing phase separation for at least two months under accelerated aging conditions.
- the method may further include maintaining viability, stability, and/or compatibility with the whitening agent under accelerated aging conditions.
- the method may include maintaining viability, stability, and/or compatibility with the whitening agent for at least three months.
- a control composition (1) and two exemplary compositions of the present invention (2) and (3) are evaluated. All three compositions were prepared by combining the ingredients/components according to Table 1, in accordance with methods known to those skilled in the art. All three compositions contained hydrogen peroxide, as delivered from a cross-linked PVP complexed with hydrogen peroxide. As illustrated in Table 1, the control composition (1) contained fumed silica and polyvinylpyrrolidone (PVP) as the thickener, and the exemplary compositions of the present invention (2) and (3) contained only the copolymer of the ammonium salt of 2-acrylamidomethylpropanesulphonic acid and N-vinylpyrrolidone as the thickener.
- PVP polyvinylpyrrolidone
- compositions (1)-(3) were evaluated by observing phase separation under accelerated aging conditions (at about 50° C.) for two months, and assigning a score on a scale of 0 to 4 to the observed phase separation. A score of ‘0’ indicated no separation, a score of “1” indicated trace amount separation, a score of “2” indicated slight separation, a score of “3” indicated moderate separation, and a score of ‘4’ indicated failure or separation.
- the results of the stability are summarized in Table 2.
- control composition (1) exhibited phase separation and received a phase separation score of 2
- exemplary compositions of the present invention (2) and (3) exhibited no phase separation and received a score of 0.
- the intermolecular network formed between the polymers of the block-copolymer in the exemplary compositions of the present invention (2) and (3) at least partially prevented solids from “settling,” and thus, prevented phase separation.
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Abstract
Anhydrous oral care compositions and methods for preventing phase separation in the anhydrous oral care composition are disclosed. The oral care composition may include an orally acceptable vehicle, a thickening system, and a whitening agent. The orally acceptable vehicle may include propylene glycol, and the thickening system may include a polymeric thickener. The polymeric thickener may be or include a copolymer of 2-acrylamidomethylpropanesulphonic acid or a salt thereof.
Description
- Conventional oral care products or compositions thereof (e.g., toothpastes, gels, etc.) including whitening agents are often utilized to whiten teeth. For example, conventional toothpastes including peroxides (e.g., hydrogen peroxide) are often utilized to oxidize chromophores bound to surfaces of teeth to thereby whiten the teeth. The peroxides, however, are often unstable and subject to degradation. As such, the peroxides are often incorporated into non-aqueous oral care products and/or compositions to aid in stabilizing the peroxides. While non-aqueous oral care compositions, such as non-aqueous toothpastes, have proven to be effective for stabilizing the peroxides, gelling agents and/or thickeners that are compatible with propylene glycol are limited.
- In view of the foregoing, non-aqueous oral care compositions incorporating hydrogen peroxide often utilize a limited selection of conventional thickeners to facilitate the thickening and/or gelling of the oral care compositions. For example, the non-aqueous oral care compositions often incorporate fumed silica and/or cross-linked polymers (e.g., cross-linked PVP) to thicken and/or gel the oral care compositions. The conventional thickeners, however, are not able to form networks with one another. As such, solids contained in the oral care compositions may often settle, thereby resulting in phase separation within the oral care com positions.
- What is needed, then, are improved non-aqueous oral care compositions incorporating a whitening agent and methods for preventing phase separation therein.
- This summary is intended merely to introduce a simplified summary of some aspects of one or more implementations of the present disclosure. Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. This summary is not an extensive overview, nor is it intended to identify key or critical elements of the present teachings, nor to delineate the scope of the disclosure. Rather, its purpose is merely to present one or more concepts in simplified form as a prelude to the detailed description below.
- The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing an anhydrous oral care composition including an orally acceptable vehicle, a thickening system, and a whitening agent. The orally acceptable vehicle may include propylene glycol, and the thickening system may include an polymeric thickener that may be a copolymer of 2-acrylamidomethylpropanesulphonic acid or a salt thereof.
- In at least one implementation, the polymeric thickener may be a block copolymer.
- In another implementation, the polymeric thickener may include a block copolymer of a first monomer and a second monomer. The first monomer may include the 2-acrylamidomethylpropanesulphonic acid or a salt thereof, and the second monomer may include a vinyl monomer having a nitrogenous side chain.
- In another implementation, the vinyl monomer may be or include at least one of a methacrylic acid, a methacrylate, a methacrylamide, a methacrylate salt, a vinyl pyrrolidone, and combinations thereof.
- In another implementation, the first monomer may be an ammonium salt of 2-acrylamidomethylpropanesulphonic acid.
- In another implementation, the second monomer may include a vinyl monomer having an amide functional group.
- In another implementation, the second monomer may be N-vinylpyrrolidone.
- In another implementation, the polymeric thickener may be a copolymer of an ammonium salt of 2-acrylamidomethylpropanesulphonic acid and a N-vinylpyrrolidone.
- In another implementation, the thickening system may include or consist of a copolymer of an ammonium salt of 2-acrylamidomethylpropanesulphonic acid and a N-vinylpyrrolidone.
- In another implementation, the anhydrous oral care composition may be substantially free of fluoride.
- In another implementation, the anhydrous oral care composition may not include or be free of fumed silica and cross-linked polyvinylpyrrolidone.
- In another implementation, the oral care composition may include less than 5.0 weight % water, preferably less than 1.0 weight % water, and more preferably less than 0.1 weight % water.
- In another implementation, the whitening agent may include a cross-linked polyvinylpyrrolidone (PVP) hydrogen peroxide complex.
- The foregoing and/or other aspects and utilities embodied in the present disclosure may be achieved by providing a method for preventing phase separation in an anhydrous oral care composition. The method may include contacting an orally acceptable vehicle including propylene glycol and a whitening agent with one another to form the oral care composition, and contacting the anhydrous oral care composition with a polymeric thickener.
- In at least one implementation, the polymeric thickener may include a block copolymer of a first monomer and a second monomer, wherein the first monomer may include an acrylamide having a sulfonic group, and wherein the second monomer may include a vinyl monomer having a nitrogenous side chain, preferably, the polymeric thickener is a copolymer of an ammonium salt of 2-acrylamidomethylpropanesulphonic acid and a N-vinylpyrrolidone
- Further areas of applicability of the present disclosure will become apparent from the detailed description provided hereinafter. It should be understood that the detailed description and specific examples, while indicating some typical aspects of the disclosure, are intended for purposes of illustration only and are not intended to limit the scope of the disclosure.
- The following description of various aspect(s) is merely exemplary in nature and is in no way intended to limit the disclosure, its application, or uses.
- As used throughout, ranges are used as shorthand for describing each and every value that is within the range. Any value within the range may be selected as the terminus of the range. In addition, all references cited herein are hereby incorporated by reference in their entireties. In the event of a conflict in a definition in the present disclosure and that of a cited reference, the present disclosure controls.
- Unless otherwise specified, all percentages and amounts expressed herein and elsewhere in the specification should be understood to refer to percentages by weight. The amounts given are based on the active weight of the material.
- Additionally, all numerical values are “about” or “approximately” the indicated value, and take into account experimental error and variations that would be expected by a person having ordinary skill in the art. It should be appreciated that all numerical values and ranges disclosed herein are approximate values and ranges, whether “about” is used in conjunction therewith.
- The present inventors have surprisingly and unexpectedly discovered that polymers or polymeric thickeners effectively prevent phase separation in oral care compositions incorporating whitening agents (e.g., peroxides). The polymeric thickener may be or include a copolymer of a first monomer, such as a 2-acrylamidomethylpropanesulphonic acid or a salt thereof, and a second monomer, such as a methacrylic acid, methacrylates, methacrylamides, methacrylate salts, and vinylpyrrolidone, effectively prevents phase separation in oral care compositions incorporating whitening agents (e.g., peroxides). Particularly, the present inventors have surprisingly and unexpectedly discovered that a block copolymer of a 2-acrylamidomethylpropanesulphonic acid salt and N-vinylpyrrolidone effectively prevents phase separation in non-aqueous oral care compositions incorporating whitening agents (e.g., peroxides). The present inventors have also surprisingly and unexpectedly discovered that the block copolymer of a 2-acrylamidomethylpropanesulphonic acid salt and N-vinylpyrrolidone is an effective thickener for non-aqueous oral care compositions. The present inventors have further surprisingly and unexpectedly discovered that the block copolymer of a 2-acrylamidomethylpropanesulphonic acid salt and N-vinylpyrrolidone is compatible with and/or maintains stability of the whitening agents of the oral care compositions. It was further surprisingly and unexpectedly discovered that the oral care composition exhibited stability (e.g., no phase separation) for at least two months when exposed to accelerated aging conditions.
- Compositions disclosed herein may be or include an oral care product and/or an oral care composition thereof. The oral care composition may be a non-aqueous oral care composition, such as a non-aqueous dentifrice or toothpaste. The oral care composition may include an orally acceptable vehicle, such as propylene glycol, one or more whitening agents, and a thickener. In at least one implementation, the thickener of the oral care composition does not include fumed silica and/or a cross-linked polymer, such as cross-linked polyvinylpyrrolidone.
- The oral care composition prior to use may be anhydrous. For example, the oral care composition may be free or substantially free of water. As used herein, “free” or “substantially free” may refer to a composition that contains less than 5.0 weight %, less than 3.0 weight %, less than 1.0 weight %, less than 0.1 weight %, less than 0.05 weight %, less than 0.01 weight %, less than 0.005 weight %, or less than 0.0001 weight % based on a total weight of the oral care composition. The oral care composition prior to use may have a “low water content”. As used herein, “low water content” may refer to a composition that contains greater than about 5 weight % and less than about 7 weight % or less than about 10 weight %.
- The oral care composition may form at least a portion of or be used in one or more oral care products. Illustrative oral care products may include, but are not limited to, a toothpaste (dentifrice), a prophylactic paste, a tooth powder, a tooth polish, a tooth gel (e.g., a whitening gel), a chewing gum, a lozenge, a mouthwash, a whitening strip, a paint-on gel, varnish, veneer, and tube, syringe or dental tray comprising a gel or paste, or a gel or paste coated on an application support such as dental floss or a toothbrush (e.g., a manual, electric, sound, a combination thereof or ultrasound toothbrush). In a typical implementation, the oral care composition may form at least a portion of or be used with a toothpaste. For example, the oral care composition may typically be a gel of the toothpaste, or a whitening gel to be combined with the toothpaste. The oral care composition may include or be combined with an orally acceptable vehicle to form the oral care product (e.g., the toothpaste). In an exemplary implementation, the orally acceptable vehicle may be or include propylene glycol.
- In at least one implementation, the orally acceptable vehicle may include one or more humectants. Illustrative humectants may be or include, but are not limited to, glycerin, propylene glycol, and combinations thereof. In a preferred implementation, the orally acceptable vehicle may be or includes, but is not limited to, propylene glycol. The propylene glycol may be present in an amount of from 20 weight % to about 75 weight %, based on a total weight of the oral care composition. For example, the propylene glycol may be present in an amount of from about 20 weight %, about 25 weight %, about 30 weight %, about 35 weight %, about 40 weight %, or about 45 weight % to about 50 weight %, about 55 weight %, about 60 weight %, about 65 weight %, about 70 weight %, or about 75 weight %. In another example, the propylene glycol may be present in an amount of from about 20 weight % to about 75 weight %, about 25 weight % to about 70 weight %, about 30 weight % to about 65 weight %, about 35 weight % to about 60 weight %, about 40 weight % to about 55 weight %, or about 45 weight % to about 50 weight %. In a preferred embodiment, the propylene glycol may be present in an amount of about 45 weight % to about 50 weight %, or in an amount of about 60 weight % to about 70 weight %.
- The oral care composition may include one or more whitening agents. The whitening agents may be or include, but are not limited to, hydrogen peroxide or one or more sources of hydrogen peroxide. For example, the whitening agents may be hydrogen peroxide and/or hydrogen peroxide releasing substances. The one or more sources of hydrogen peroxide may be or include any compound or material configured to release hydrogen peroxide. Preferably, the whitening agents include, but are not limited to, solid whitening agents and bound whitening agents which are substantially anhydrous oxygen generating compounds. Solid whitening agents useful herein include peroxides, persulfate. Exemplary peroxide phases include hydroperoxides, hydrogen peroxide, peroxides of alkali and alkaline earth metals, organic peroxy compounds, peroxy acids, pharmaceutically-acceptable salts thereof, and mixtures thereof. Peroxides of alkali and alkaline earth metals include, but are not limited to, lithium peroxide, potassium peroxide, sodium peroxide, magnesium peroxide, calcium peroxide, barium peroxide, and mixtures thereof. Organic peroxy compounds include, but are not limited to, urea peroxide, glyceryl hydrogen peroxide, alkyl hydrogen peroxides, dialkyl peroxides, alkyl peroxy acids, peroxy esters, diacyl peroxides, benzoyl peroxide, and monoperoxyphthalate, and mixtures thereof. Peroxy acids and their salts include, but are not limited to, organic peroxy acids such as alkyl peroxy acids, and monoperoxyphthalate and mixtures thereof, as well as inorganic peroxy acid salts such as and perborate salts of alkali and alkaline earth metals such as lithium, potassium, sodium, magnesium, calcium and barium, and mixtures thereof. Preferred solid peroxides are sodium perborate, urea peroxide, and mixtures thereof. The whitening agents may be preferably bound. For example, peroxide may be bound to a polymer such as PVP (poly(N-vinylpyrrolidone). Suitable PVP complexes are disclosed, for example, in U.S. Pat. No. 5,122,370, the contents of which are incorporated herein by reference. In some embodiments, it may be desirable to use any known whitening agent except sodium percarbonate and/or any of the percarbonate salts. The sources of hydrogen peroxide or whitening agents may also be or include, but are not limited to, PEROXYDONE™ XL 10 complex or POLYPLASDONE® XL 10F, which are commercially available from Ashland Inc. of Covington, Ky.. In a typical implementation, the source of hydrogen peroxide includes a cross-linked PVP hydrogen peroxide complex.
- The amount or concentration of the source of hydrogen peroxide may vary widely. In at least one example, the source of hydrogen peroxide may be present in an amount that provides a concentration of hydrogen peroxide of less than or equal to 4 weight %, less than or equal to 3.5 weight %, less than or equal to 3 weight %, less than or equal to 2.5 weight less than or equal to 2 weight %, or less than or equal to 1.5 weight %, based on a total weight of the oral care composition. In at least one implementation, the source of hydrogen peroxide may be present in an amount greater than or equal to 1 weight % and less than or equal to 30 weight %, based on a total weight of the oral care composition. For example, the source of hydrogen peroxide may be present in an amount of from about 1 weight %, about 3 weight %, about 5 weight %, about 7 weight %, about 9 weight %, about 11 weight %, about 13 weight %, or about 15 weight % to about 17 weight %, about 19 weight %, about 21 weight %, about 22 weight %, about 23 weight %, about 25 weight %, about 27 weight %, about 29 weight %, or about 30 weight %. In another example, the source of hydrogen peroxide may be present in an amount of from about 1 weight % to about 30 weight %, about 3 weight %, about 29 weight %, about 5 weight % to about 27 weight %, about 7 weight % to about 25 weight %, about 9 weight % to about 23 weight %, about 11 weight % to about 21 weight %, about 13 weight % to about 19 weight %, or about 15 weight % to about 17 weight %. In other embodiments, the source of hydrogen peroxide is a cross-linked PVP complexed with hydrogen peroxide, and is present in an amount of from about 15 weight % to about 17 weight %, preferably about 16 weight % to about 17 weight %, and more preferably about 16.5 weight %. In further embodiments, the source of hydrogen peroxide is a cross-linked PVP complexed with hydrogen peroxide, and is present in an amount of from about 20 weight % to about 30 weight %, preferably about 21 weight % to about 25 weight %, and more preferably about 22 weight %.
- The oral care composition may include a thickening system having one or more thickeners. The one or more thickeners may be any orally acceptable thickener or thickening agent configured to at least partially form a network and thereby prevent phase separation in the oral care composition. Illustrative thickeners may be or include a polymeric thickener, such as a copolymer of at least two monomers, where a first monomer may be an acrylamide having a sulfonic or sulphonic group, and a second monomer may be a vinyl monomer having a nitrogenous side chain. Illustrative vinyl monomers may be or include, but are not limited to, methacrylic acid, methacrylates, methacrylamides, methacrylate salts, vinyl pyrrolidone, and the like, and combinations thereof. For example, the thickener may be or include a copolymer of 2-acrylamidomethylpropanesulphonic acid or a salt thereof, such as an ammonium or sodium salt, and a vinyl monomer having a nitrogenous cyclic side chain or a vinyl monomer having an amide functional group, such as N-vinylpyrrolidone. In a preferred implementation, the thickener may be a copolymer of the ammonium salt of 2-acrylamidomethylpropanesulphonic acid and N-vinylpyrrolidone, which is commercially available as ARISTOFLEX® AVC from Clariant International Ltd. of Charlotte, N.C. The block copolymer thickener may have the INCI name ammonium acryloyldimethyltaurate/VP copolymer or correspond to the GAS reference number 335383-60-3. Another preferred thickener may be a block copolymer of the sodium salt of 2-acrylamidomethylpropanesulphonic acid and N-vinylpyrrolidone, which is commercially available as ARISTOFLEX® AVS from Clariant International Ltd. of Charlotte, N.C., and has the INCI name sodium acryloyldimethyltaurate/VP crosspolymer. In yet another preferred implementation, the polymeric thickener may be ARISTOFLEX® HMB, ARISTOFLEX® BLV, and/or ARISTOFLEX® TAC, which are commercially available from Clariant International Ltd. In a further preferred implementation, the polymeric thickener may be or include polyacrylate crosspolymer-6, which is commercially available as SEPIMAX™ ZEN from SEPPIC S.A., a subsidiary of the Air Liquide group, Puteaux Cedex, France.
- In at least one implementation, the oral care composition may be free or substantially free of fumed silica. In another implementation, the oral care composition prior to use may be free or substantially free of cross-linked PVP. It should be appreciated that in at least one implementation, the oral care composition prior to use may include a cross-linked PVP complexed with hydrogen peroxide as a source of hydrogen peroxide, but may also be free or substantially free of the cross-linked PVP. In yet another implementation, the oral care composition may be free or substantially free of both fumed silica and cross-linked PVP prior to use. In yet another implementation, the oral care composition may include fumed silica and cross-linked PVP.
- The amount or concentration of the thickening system or the thickener thereof in the oral care composition may vary widely In at least one implementation, the amount of the thickener present in the oral care composition may be greater than or equal to 0.1 weight % and less than or equal to 1.0 weight %, based on a total weight of the oral care composition. For example, the amount of the thickener present in the oral care composition may be from about 0.1 weight %, about 0.2 weight %, about 0.3 weight %, about 0.4 weight %, or about 0.5 weight % to about 0.6 weight %, about 0.7 weight %, about 0.8 weight %, about 0.9 weight %, or about 1.0 weight %. In another example, the amount of the thickener present in the oral care composition may be from about 0.1 weight % to about 1.0 weight %, about 0.2 weight % to about 0.9 weight %, about 0.3 weight % to about 0.8 weight %, about 0.4 weight % to about 0.7 weight %, or about 0.5 weight % to about 0.6 weight %. In some embodiments, the amount of the thickener present in the oral care composition may be from about 0.4 weight % to about 0.6 weight %, optionally about 0.4 weight % or about 0.55 weight %.
- In another implementation, the amount of the thickener present in the oral care composition may be greater than 0 weight % and less than or equal to 20 weight %, based on a total weight of the oral care composition. For example, the amount of the thickener present in the oral care composition may be greater than 0 weight % and less than or equal to 20 weight %, less than or equal to 18 weight %, less than or equal to 16 weight %, less than or equal to 14 weight %, less than or equal to 12 weight %; less than or equal to 10 weight %, less than or equal to 8 weight %, less than or equal to 6 weight %, less than or equal to 5 weight %, less than or equal to 4 weight %, less than or equal to 3 weight %, less than or equal to 2 weight %, less than or equal to 1.8 weight %, less than or equal to 1.6 weight %, less than or equal to 1.4 weight %, less than or equal to 1.2. weight %, less than or equal to 1.0 weight %, less than or equal to 0.8 weight %, less than or equal to 0.6 weight %, or less than or equal to 0.4 weight %.
- In at least one implementation, the oral care composition may include additional and/or optional thickeners. Illustrative additional or optional thickeners may be or include, but are not limited to, carbomers (e.g., carboxyvinyl polymers), carrageenans (e.g., Irish moss, carrageenan, iota-carrageenan, etc.), high molecular weight polyethylene glycols (e.g., CARBOWAX®, which is commercially available from The Dow Chemical Company of Midland, Mich.), cellulosic polymers, hydroxyethylcellulose, carboxymethylcellulose, and salts thereof (e.g., CMC sodium), natural gums (e.g., karaya, xanthan, gum arabic, and tragacanth), colloidal magnesium aluminum silicate, and the like, and mixtures or combinations thereof.
- In at least one implementation, the oral care composition may include one or more polymers or polymer additives. For example, the oral care composition may include one or more block co-polymers of polyethylene glycol and polyethylene glycol (e.g., molecular weight of at least 5000 Da), polypropylene glycol and polyethylene glycol, and the like, and combinations thereof. In at least one implementation, the oral care composition includes a block co-polymer of ethylene oxide and propylene oxide represented by the formula (1),
-
(ethylene oxide)x-(propylene oxide)y (1) - where x is an integer from about 80 to about 150 (e.g., x=100-130, or about 118), and y is an integer from about 30 to about 80 (e.g., y=60-70, or about 66). The block co-polymer of ethylene oxide and propylene oxide may have an average molecular weight greater than or equal to about 5,000 Da and less than or equal to about 20,000 Da. For example, the molecular weight of the block co-polymer of ethylene oxide and propylene oxide may be from about 8,000 Da to about 13,000 Da. In another example, the molecular weight of the block co-polymer of ethylene oxide and propylene oxide may be from about 9,800 Da or about 10,000 Da. In yet another example, the molecular weight of the block co-polymer of ethylene oxide and propylene oxide may be from about 8,000 Da to about 10,000 Da. In at least one implementation, the oral care composition does not include a block co-polymer of ethylene oxide and propylene oxide having a molecular weight less than 5,000 Da. For example, at least 99.5%, at least 99.0%, or at least 99.9% of the block co-polymer of ethylene oxide and propylene oxide present in the oral care composition has a molecular weight greater than or equal to 5,000 Da. In at least one implementation, the polymers or polymer additives, if included in the composition, may be or include PLURAFLO® L4370 and PLURAFLO® L1220, both of which are commercially available from B A SF of Wyandotte, Mich.
- The amount or concentration of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may vary widely. In at least one implementation, the amount of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may be from about 5 weight % to about 10 weight %. For example, the amount of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may be from about 5.0 weight %, about 5.5 weight %, about 6.0 weight %, about 6.5 weight %, about 7.0 weight %, or about 7.5 weight % to about 8.0 weight %, about 8.5 weight %, about 9.0 weight %, about 9.5 weight %, or about 10.0 weight %. In another example, the amount of the polymers or polymer additives present in the oral care composition may be from about 5.0 weight % to about 10.0 weight %, about 5.5 weight % to about 9.5 weight %, about 6.0 weight % to about 9.0 weight %, about 6.5 weight % to about 8.5 weight %, or about 7.0 weight % to about 8.0 weight %. In another implementation, the amount of the polymer or polymer additives present in the oral care composition may be from about 5 weight % to about 15 weight % based on a total weight of the oral care composition. For example, the amount of the polymers or polymer additives (e.g., block co-polymers) present in the oral care composition may be from about 5.0 weight %, about 5.5 weight %, about 6.0 weight %, about 6.5 weight %, about 7.0 weight %, about 7.5 weight %, about 8.0 weight %, about 8.5 weight %, about 9.0 weight %, about 9.5 weight %, or about 10.0 weight % to about 10.5 weight %, about 11.0 weight %, about 11.5 weight %, about 12.0 weight %, about 12.5 weight %, about 13.0 weight %, about 13.5 weight %, about 14.0 weight %, about 14.5 weight %, or about 15.0 weight %.
- In at least one implementation, the polymers or polymer additives may be or include PLURACARE® L1220, which is commercially available from BASF of Wyandotte, Mich. In another implementation, the polymer or polymer additive may be or include polyethylene glycol (e.g., about 400-800 Da, or about 600 Da). In yet another implementation, the polymer or polymer additive may be or include a low or medium molecular weight polyethylene glycol having a molecular weight greater than or equal to about 400 Da and less than or equal to about 1000 Da. For example, the polymer or polymer additive may be or include PEG 400, PEG 600, PEG 800, PEG 100, and the like, and mixtures or combinations thereof. In at least one implementation, the oral care composition may include a stabilizing amount of an additional linear PVP.
- The oral care composition may include a surfactant or surfactant system including one or more surfactants. The surfactant may be configured to at least partially aid or facilitate the mixing or contact between one or more components of the oral care composition. For example, the surfactant may aid the mixing or facilitate contact between a hydrophobic component/phase and a hydrophilic component/phase of the oral care composition. The surfactants may be or include anionic, nonionic, cationic, amphoteric surfactants, or combinations thereof.
- Illustrative surfactants may be or include, but are not limited to, water-soluble salts of C8-20 alkyl sulfates, sulfonated monoglycerides of C8-20 fatty acids, sarcosinates, taurates, sodium lauryl sulfate, sodium cocoyl monoglyceride sulfonate, sodium lauryl sarcosinate, sodium lauryl isoethionate, sodium laureth carboxylate, and sodium dodecyl benzenesulfonate, and cocoamidopropyl betaine. Illustrative surfactants or surface active agents may also be or include, but are not limited to, PLURONIC® L35, PLURONIC® L43, PLURONIC® L64, PLURONIC® L10, PLURONIC® L44, PLURONIC® L62, PLURONIC® 10R5, PLURONIC® 17R4, PLURONIC® L25R4, PLURONIC® P84, PLURONIC P65, PLURONIC® P104, PLURONIC® P105, and the like, and combinations thereof, which are commercially available from BASF of Mount Olive, N.J. In a typical implementation, the surfactant is or includes a polyethylene glycol)-block-poly(propylene glycol)-block-polyethylene glycol) or PEG-PPG-PEG (PLURONIC® L-35).
- The amount of the surfactants present in the oral care composition may vary widely. In at least one implementation, the amount of one or more surfactants present in the oral care composition may be greater than or equal to 0.0 weight % and less than or equal to 10.0 weight %, based on a total weight of the oral care composition. For example, the amount of the surfactant present in the oral care composition may be from about 0.0 weight %, about 1 weight %, about 2 weight %, about 3 weight %, about 4 weight %, or about 4.5 weight % to about 5.5 weight %, about 6 weight %, about 7 weight %, about 8 weight %, about 9 weight %, or about 10 weight %, based on a total weight of the oral care composition. In another example, the amount of the surfactant present in the oral care composition may be from about 0.0 weight % to about 10 weight %, about 1 weight % to about 9 weight %, about 2 weight % to about 8 weight %, about 3 weight % to about 7 weight %, about 4 weight % to about 6 weight %, or about 4.5 weight % to about 5.5 weight %, based on a total weight of the oral care composition. In a preferred implementation, the amount of the surfactant present in the oral care composition may be from about 4 weight % to about 6 weight %, more preferably about 4.5 weight % to about 5.5 weight %, more preferably about 5.0 weight %, based on a total weight of the oral care composition.
- In at least one implementation, the oral care composition may include one or more abrasives or dental abrasive agents. As used herein, the term “abrasive” may also refer to materials commonly referred to as “polishing agents”.
- Any suitable orally acceptable abrasive may be used, but preferably, the type, fineness (particle size) and amount of the abrasives should be selected such that tooth enamel is not excessively abraded in normal use of the oral care composition.
- Suitable abrasives include without limitation silica, for example in the form of silica gel, hydrated silica or precipitated silica, alumina, insoluble phosphates, calcium carbonate, resinous abrasives such as urea-formaldehyde condensation products and the like. Among insoluble phosphates useful as abrasives are orthophosphates, polymetaphosphates and pyrophosphates. Illustrative examples are dicalcium orthophosphate dihydrate, calcium pyrophosphate, (3-calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate and insoluble sodium polymetaphosphate. Average particle size of an abrasive, if present, is generally about 0.1 to about 30 μm, for example about 1 to about 20 μm or about 5 to about 15 μm. In at least one implementation, the abrasive may be maintained in the dentifrice of the oral care composition.
- In at least one implementation, the amount or concentration of the abrasives may be from about 5 wt % to about 40 wt %, based on a total weight of the oral care composition. For example, the amount of the abrasives present in the oral care composition may be from about 5.0 wt %, about 5.5 wt %, about 6.0 wt %, about 6.5 wt %, about 7.0 wt %, about 7.5 wt %, about 8.0 wt %, about 8.5 wt %, about 9.0 wt %, about 9.5 wt %, about 10.0 wt %, about 10.5 wt %, about 11.0 wt %, about 11.5 wt %, or about 12.0 wt % to about 12.5 wt %, about 13.0 wt %, about 13.5 wt %, about 14.0 wt %, about 14.5 wt %, about 15.0 wt %, about 15.5 wt %, about 16.0 wt %, about 16.5 wt %, about 17.0 wt %, about 17.5 wt %, about 18.0 wt %, about 18.5 wt %, about 19.0 wt %, about 19.5 wt %, or about 20.0 wt %. In another example, the amount of the abrasives present in the oral care composition may be from about 5 wt %, about 10 wt %, about 15 wt %, or about 20 wt % to about 25 wt %, about 30 wt %, about 35 wt %, or about 40 wt %.
- In at least one implementation, the oral care products and/or the oral care composition thereof may be free or substantially free of fluoride (e.g., soluble fluoride salts). In another implementation, the oral care products and/or the oral care composition thereof may further include fluoride, such as one or more fluoride ion sources (e.g., soluble fluoride salts). A wide variety of fluoride ion-yielding materials may be employed as sources of soluble fluoride. Examples of suitable fluoride ion-yielding materials may be found in U.S. Pat. No. 3,5.35,421 to Briner et al., U.S. Pat. No. 4,885,155 to Parran, Jr. et al., and U.S. Pat. No. 3,678,154 to Widder et al., the disclosures of which are incorporated herein by reference. Illustrative fluoride ion sources include, but are not limited to, fluoride, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, fluorosilicate salts, such as sodium fluorosilicate and ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof. In a typical implementation, the fluoride ion source includes sodium fluoride. The amount of the fluoride ion source in the oral care composition may be less than 0.08 wt %, less than 0.07 wt %, less than 0.06 wt %, less than 0.05 wt %, or less than 0.04 wt %. For example, the amount of the fluoride ion source may be about 0.05 wt %. In another implementation, the fluoride ion source is present in an amount to provide a total of about 100 to about 20,000 ppm, about 200 to about 5,000 ppm, or about 500 to about 2,500 ppm, fluoride ions.
- It should be appreciated to one having ordinary skill in the art, that the oral care products and/or the oral care composition thereof may include other additional ingredients/components. For example, the oral care products and/or the oral care composition thereof may include anti-caries agents, desensitizing agents, viscosity modifiers, diluents, pH modifying agents, humectants, mouth feel agents, sweetening agents, flavor agents, colorants, preservatives, and the like, and combinations and mixtures thereof. In some embodiments, the compositions described herein are substantially free of volatile flavoring agents. In other embodiments, the compositions described herein are completely free of volatile flavoring agents. It should further be appreciated by one having ordinary skill in the art that while general attributes of each of the above categories of materials may differ, there may be some common attributes and any given material may serve multiple purposes within two or more of such categories of materials.
- In at least one implementation, the additional ingredients/components may include one or more active materials configured to prevent and/or treat one or more conditions and/or disorders of the oral cavity. For example, the one or more active materials may be configured to prevent and/or treat one or more conditions and/or disorders of hard and/or soft tissue of the oral cavity. The active materials may also be configured to prevent and/or treat one or more physiological disorders and/or conditions, and/or provide a cosmetic benefit to the oral cavity.
- In at least one implementation, the oral care products or the oral care composition thereof may include an anticalculus agent. Generally, anticalculus agents may not be compatible with some oral care composition, however, implementations of the present disclosure may incorporate anticalculus agents and the oral care composition into a single phase oral care product. Illustrative anticalculus agents may include, but are not limited to, phosphates and polyphosphates (e.g., pyrophosphates), polyaminopropanesulfonic acid (AMPS), hexametaphosphate salts, zinc citrate trihydrate, polypeptides, polyolefin sulfonates, polyolefin phosphates, diphosphonates. In a typical implementation, the anticalculus agents includes tetrasodium pyrophosphate (TSPP), sodium tripolyphosphate (STPP), or a combination thereof.
- The oral care products or the oral care composition thereof may include an antioxidant. Any orally acceptable antioxidant may be used, including, but not limited to, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), vitamin A, carotenoids, vitamin E, flavonoids, polyphenois, ascorbic acid, herbal antioxidants, chlorophyll, melatonin, and the like, and combinations and mixtures thereof.
- It should be appreciated that all ingredients for use in the compositions described herein are orally acceptable. As used herein, the expression “orally acceptable” may define an ingredient that is present in a composition as described in an amount and form that does not render the composition unsafe for use in the oral cavity.
- The present disclosure may provide methods for preventing phase separation in an oral care product or the oral care composition thereof that incorporate whitening agents (e.g., peroxides). The method may include contacting the oral care composition with a polymeric thickener having a first monomer, such as a 2-acrylamidomethylpropanesulphonic acid or a salt thereof, and a second monomer, such as a methacrylic acid, methacrylates, methacrylamides, methacrylate salts, and vinylpyrrolidone. The oral care composition may be a non-aqueous or propylene glycol based oral care composition. The method may include not combining at least one other thickener, such as fumed silica and cross-linked polyvinylpyrrolidone. The method may also include forming a intermolecular bonding network between a plurality of the polymers of the polymeric thickener to prevent phase separation. The method may include preventing phase separation under accelerated aging conditions, for example at a temperature from about 40° C. to about 50° C. The method may include preventing phase separation for at least two months under accelerated aging conditions. The method may further include maintaining viability, stability, and/or compatibility with the whitening agent under accelerated aging conditions. For example, the method may include maintaining viability, stability, and/or compatibility with the whitening agent for at least three months.
- The following example and other implementations described herein are exemplary and not intended to be limiting in describing the full scope of compositions and methods of this disclosure. Equivalent changes, modifications and variations of specific implementations, materials, compositions and methods may be made within the scope of the present disclosure, with substantially similar results.
- A control composition (1) and two exemplary compositions of the present invention (2) and (3), are evaluated. All three compositions were prepared by combining the ingredients/components according to Table 1, in accordance with methods known to those skilled in the art. All three compositions contained hydrogen peroxide, as delivered from a cross-linked PVP complexed with hydrogen peroxide. As illustrated in Table 1, the control composition (1) contained fumed silica and polyvinylpyrrolidone (PVP) as the thickener, and the exemplary compositions of the present invention (2) and (3) contained only the copolymer of the ammonium salt of 2-acrylamidomethylpropanesulphonic acid and N-vinylpyrrolidone as the thickener.
- The stability of compositions (1)-(3) were evaluated by observing phase separation under accelerated aging conditions (at about 50° C.) for two months, and assigning a score on a scale of 0 to 4 to the observed phase separation. A score of ‘0’ indicated no separation, a score of “1” indicated trace amount separation, a score of “2” indicated slight separation, a score of “3” indicated moderate separation, and a score of ‘4’ indicated failure or separation. The results of the stability are summarized in Table 2.
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TABLE 1 Control (1) and Exemplary Whitening Compositions (2) and (3) Control (1) Ex. (2) Ex. (3) Material Wt. % Propylene glycol 48.76 52.96 67.75 Sodium metaphosphate 15.00 15.00 — Polyethylene glycol/polypropylene 7.50 7.50 7.50 glycol copolymer Copolymer of ammonium salt of 2- — 0.55 0.40 acrylamidomethylpropanesulphonic acid and N-vinylpyrrolidone Cross-linked PVP complexed with 16.50 16.50 22.00 hydrogen peroxide Polyvinylpyrrolidone 2.00 — — Fumed silica 2.75 — — Other (e.g. flavor, colorants, etc.) 3.13 3.13 0.85 Pyrophosphates (e.g. TSPP and/or 1.60 1.60 0.50 SAPP) Sodium lauryl sulfate 2.00 2.00 1.00 Fluoride source 0.76 0.76 — Total 100 100 100 -
TABLE 2 Formulation Separation Rating after Aging at 49° C. for 2 months Control (1) Exemplary Composition (2) Exemplary Composition (3) 2 0 0 - As indicated in Table 2, the control composition (1) exhibited phase separation and received a phase separation score of 2, while the exemplary compositions of the present invention (2) and (3) exhibited no phase separation and received a score of 0. Without being bound by theory, it is believed that the intermolecular network formed between the polymers of the block-copolymer in the exemplary compositions of the present invention (2) and (3), at least partially prevented solids from “settling,” and thus, prevented phase separation.
- The viability, stability, and/or compatibility of the polymeric block copolymer thickener with the whitening agent of the exemplary compositions of the present invention (2) and (3) were also evaluated under accelerated aging conditions (at 40° C.) for at least three months. The results are summarized in Table 3.
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TABLE 3 Recovery of Peroxide from Exemplary Composition (2) and (3) after Aging at 40° C. for 3 months Time 0 Weeks Aged Recovery Control (1) 2.99 2.70 90.1% Ex. (2) 3.01 2.94 97.7% Ex. (3) 4.01 4.00 99.8% - As indicated in Table 3, about 98% peroxide was recovered after exposing the exemplary compositions of the present invention (2) and (3) to accelerated aging conditions for at least three months. This demonstrated that the polymeric block copolymer thickener was compatible with the whitening agent, and maintained the viability and stability of the whitening agent.
- The present disclosure has been described with reference to exemplary implementations. Although a limited number of implementations have been shown and described, it will be appreciated by those skilled in the art that changes may be made in these implementations without departing from the principles and spirit of the preceding detailed description. It is intended that the present disclosure be construed as including all such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (21)
1-17. (canceled)
18. An oral care composition, comprising:
an orally acceptable vehicle;
a thickening system, the thickening system comprising polyacrylate crosspolymer-6; and
a peroxide whitening agent.
19. The oral care composition of claim 18 , wherein the peroxide whitening agent is hydrogen peroxide.
20. The oral care composition of claim 18 , wherein the peroxide whitening agent is a source of hydrogen peroxide in an amount that provides a concentration of hydrogen peroxide of less than or equal to 4 weight %.
21. The oral care composition of claim 18 , further comprising an abrasive.
22. The oral care composition of claim 21 , wherein the abrasive comprises calcium pyrophosphate.
23. The oral care composition of claim 18 , further comprising an anticalculus agent.
24. The oral care composition of claim 23 , wherein the anticalculus agent comprises tetrasodium pyrophosphate.
25. The oral care composition of claim 18 , further comprising a humectant.
26. The oral care composition of claim 25 , wherein the humectant comprises glycerin.
27. The oral care composition of claim 18 , further comprising a surfactant.
28. The oral care composition of claim 25 , wherein the surfactant comprises sodium lauryl sulfate.
29. The oral care composition of claim 18 , further comprising one or more pyrophosphate salts.
30. The oral care composition of claim 29 , wherein the pyrophosphate salts are selected from calcium pyrophosphate and tetrasodium pyrophosphate.
31. An oral care composition, comprising:
an orally acceptable vehicle, the orally acceptable vehicle comprising glycerin;
a thickening system, the thickening system comprising polyacrylate crosspolymer-6;
a peroxide whitening agent that is a source of hydrogen peroxide;
an abrasive component comprising calcium pyrophosphate; and
an anticalculus agent comprising tetrasodium pyrophosphate.
32. The oral care composition of claim 31 , wherein the source of hydrogen peroxide is present in an amount that provides a concentration of hydrogen peroxide of less than or equal to 4 weight %.
33. The oral care composition of claim 32 , further comprising a surfactant.
34. The oral care composition of claim 33 , wherein the surfactant comprises sodium lauryl sulfate.
35. The oral care composition of claim 31 , wherein:
the orally acceptable vehicle comprises glycerin;
the thickening system comprises polyacrylate crosspolymer-6;
the source of hydrogen peroxide is present in an amount that provides a concentration of hydrogen peroxide of less than or equal to 4 weight %;
the abrasive is calcium pyrophosphate; and
the anticalculus agent comprises tetrasodium pyrophosphate, and optionally, one or more additional pyrophosphate anticalculus agents.
36. A method for whitening a tooth of a subject need thereof, comprising contacting an oral cavity surface of said subject with an oral care composition according to claim 18 .
37. A method for whitening a tooth of a subject need thereof, comprising contacting an oral cavity surface of said subject with an oral care composition according to claim 31 .
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US17/472,252 US20210401699A1 (en) | 2017-12-13 | 2021-09-10 | Oral Care Compositions and Methods for Increasing Stability of the Same |
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PCT/US2017/066032 WO2019117885A1 (en) | 2017-12-13 | 2017-12-13 | Oral care compositions and methods for increasing stability of the same |
US201815756146A | 2018-02-28 | 2018-02-28 | |
US17/472,252 US20210401699A1 (en) | 2017-12-13 | 2021-09-10 | Oral Care Compositions and Methods for Increasing Stability of the Same |
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PCT/US2017/066032 Continuation WO2019117885A1 (en) | 2017-12-13 | 2017-12-13 | Oral care compositions and methods for increasing stability of the same |
US15/756,146 Continuation US11278478B2 (en) | 2017-12-13 | 2017-12-13 | Oral care compositions and methods for increasing stability of the same |
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US20210401699A1 true US20210401699A1 (en) | 2021-12-30 |
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US17/472,252 Abandoned US20210401699A1 (en) | 2017-12-13 | 2021-09-10 | Oral Care Compositions and Methods for Increasing Stability of the Same |
US17/700,184 Abandoned US20220211595A1 (en) | 2017-12-13 | 2022-03-21 | Oral Care Compositions and Methods for Increasing Stability of the Same |
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US15/756,146 Active 2038-12-13 US11278478B2 (en) | 2017-12-13 | 2017-12-13 | Oral care compositions and methods for increasing stability of the same |
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US17/700,184 Abandoned US20220211595A1 (en) | 2017-12-13 | 2022-03-21 | Oral Care Compositions and Methods for Increasing Stability of the Same |
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EP (1) | EP3723710A1 (en) |
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CA (1) | CA3082088A1 (en) |
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Cited By (1)
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US20220211595A1 (en) * | 2017-12-13 | 2022-07-07 | Colgate-Palmolive Company | Oral Care Compositions and Methods for Increasing Stability of the Same |
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EP2654677B1 (en) | 2010-12-22 | 2018-04-04 | Colgate-Palmolive Company | Oral care compositions |
CA3155478A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and metal ion |
WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
US11324677B1 (en) | 2020-11-06 | 2022-05-10 | Colgate-Palmolive Company | Oral care whitening compositions |
EP4366680A1 (en) * | 2021-08-13 | 2024-05-15 | Colgate-Palmolive Company | Oral care compositions |
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2017
- 2017-12-13 US US15/756,146 patent/US11278478B2/en active Active
- 2017-12-13 CA CA3082088A patent/CA3082088A1/en active Pending
- 2017-12-13 CN CN201780097363.3A patent/CN111417375A/en active Pending
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2020
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2021
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- 2021-11-17 AU AU2021269346A patent/AU2021269346A1/en not_active Abandoned
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- 2022-03-21 US US17/700,184 patent/US20220211595A1/en not_active Abandoned
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US20220211595A1 (en) | 2022-07-07 |
US11278478B2 (en) | 2022-03-22 |
WO2019117885A1 (en) | 2019-06-20 |
ZA202001720B (en) | 2023-10-25 |
AU2017442632B2 (en) | 2021-08-19 |
CN111417375A (en) | 2020-07-14 |
AU2017442632A1 (en) | 2020-07-23 |
MX2020006002A (en) | 2022-05-27 |
CA3082088A1 (en) | 2019-06-20 |
AU2021269346A1 (en) | 2021-12-09 |
EP3723710A1 (en) | 2020-10-21 |
US20190175466A1 (en) | 2019-06-13 |
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