US20210290225A1 - Surgical instrument with lockout mechanism - Google Patents
Surgical instrument with lockout mechanism Download PDFInfo
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- US20210290225A1 US20210290225A1 US17/341,929 US202117341929A US2021290225A1 US 20210290225 A1 US20210290225 A1 US 20210290225A1 US 202117341929 A US202117341929 A US 202117341929A US 2021290225 A1 US2021290225 A1 US 2021290225A1
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- Prior art keywords
- surgical instrument
- approximation
- assembly
- stopper
- handle
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- 230000007246 mechanism Effects 0.000 title claims abstract description 36
- 238000000034 method Methods 0.000 claims description 35
- 238000010304 firing Methods 0.000 claims description 34
- 230000000903 blocking effect Effects 0.000 claims description 23
- 210000001519 tissue Anatomy 0.000 description 25
- 210000000056 organ Anatomy 0.000 description 9
- 230000003872 anastomosis Effects 0.000 description 7
- 208000014617 hemorrhoid Diseases 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 239000012207 thread-locking agent Substances 0.000 description 2
- 238000003466 welding Methods 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000000135 prohibitive effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/068—Surgical staplers, e.g. containing multiple staples or clamps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B17/115—Staplers for performing anastomosis in a single operation
- A61B17/1155—Circular staplers comprising a plurality of staples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00367—Details of actuation of instruments, e.g. relations between pushing buttons, or the like, and activation of the tool, working tip, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00526—Methods of manufacturing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0807—Indication means
- A61B2090/0811—Indication means for the position of a particular part of an instrument with respect to the rest of the instrument, e.g. position of the anvil of a stapling instrument
Definitions
- the present disclosure relates generally to a surgical fastening instrument for applying surgical fasteners to body tissue. More particularly, the present disclosure relates to a surgical fastening instrument that is locked out from firing fasteners until the cartridge assembly and anvil assembly are sufficiently approximated.
- Anastomosis is the surgical joining of separate hollow organ sections.
- an anastomosis procedure follows surgery in which a diseased or defective section of hollow tissue is removed and the remaining end sections are to be joined.
- the end sections may be joined by either circular, end-to-end or side-to-side organ reconstruction methods.
- these instruments typically include an elongated shaft having a handle portion at a proximal end to actuate the instrument and a staple holding component disposed at a distal end.
- An anvil assembly including an anvil rod with an attached anvil head is mounted to the distal end of the instrument adjacent the staple holding component.
- Opposed end portions of tissue of the hollow organ(s) to be stapled are clamped between the anvil head and the staple holding component as these components are approximated.
- the clamped tissue is stapled by actuation of a trigger to drive one or more staples from the staple holding component so that the ends of the staples pass through the tissue and are deformed by the anvil head.
- An annular knife is concurrently advanced to core tissue within the hollow organ to free a tubular passage within the organ.
- surgical stapling instruments for performing circular anastomosis have been used to treat internal hemorrhoids in the rectum.
- the anvil head and the staple holding component of the surgical stapling instrument are inserted through the anus and into the rectum with the anvil head and the staple holding component in an open or unapproximated position.
- a pursestring suture is used to pull the internal hemorrhoidal tissue towards the anvil rod.
- the anvil head and the staple holding component are approximated to clamp the hemorrhoid tissue between the anvil head and the staple holding component.
- the stapling instrument is fired to remove the hemorrhoidal tissue and staple the cut tissue.
- a strip of mucosa and submucosa at the top of the hemorrhoids is removed by the stapling instrument, thereby treating the hemorrhoids by inhibiting blood flow to the tissue.
- a surgical instrument in certain situations, it is desirable to prevent premature firing of staples. Accordingly, it would be desirable for a surgical instrument to include a lockout mechanism that prevents the movable handle from being actuated until the anvil assembly and the cartridge assembly are sufficiently approximated.
- the present disclosure relates to a surgical instrument comprising a handle assembly, an elongated portion, a head portion, an approximation mechanism, and a lockout mechanism.
- the handle assembly comprises a movable handle and a stationary handle.
- the elongated portion extends distally from the handle assembly and defines a longitudinal axis.
- the head portion is disposed adjacent a distal portion of the elongated portion, and comprises a first jaw member and a second jaw member.
- the approximation mechanism comprises a drive member disposed in mechanical cooperation with the first jaw member and is configured to longitudinally move the first jaw member in relation to the second jaw member.
- the lockout mechanism is configured to selectively permit actuation of the movable handle to eject fasteners from the second jaw member.
- the lockout mechanism comprises a pin extending from the movable handle which is slidingly engaged with a slot in the drive member.
- actuation of the approximation mechanism causes longitudinal translation of the slot with respect to the pin.
- the slot in the drive member includes a blocking portion and a firing portion.
- the movable handle When the pin is engaged with the blocking portion of the slot, the movable handle is prevented from being actuated, and when the pin is disposed between the blocking portion and the firing portion of the slot, the movable handle is able to be actuated.
- the pin is engaged between the blocking portion and the firing portion of the slot when the first jaw member and the second jaw member are in an approximated position.
- the pin is engaged with the firing portion of the slot during actuation of the movable handle.
- the firing portion of the slot is disposed distally adjacent the blocking portion of the slot.
- the blocking portion of the slot is substantially parallel to the longitudinal axis, and the firing portion of the slot is disposed at an angle with respect to the blocking portion of the slot. It is further disclosed that the firing portion of the slot is arcuate.
- the surgical instrument further comprises an approximation knob disposed adjacent a proximal portion of the drive member, and a stopper threadably engaged with a portion of the approximation knob.
- a blocking portion of the stopper is configured to contact a proximal face of the drive member.
- the handle assembly is threadably engaged with the elongated portion.
- the present disclosure also relates to a method of adjusting the minimum tissue gap between a cartridge assembly and an anvil assembly of a surgical instrument.
- the method comprises providing a surgical instrument comprising a handle assembly, an elongated portion extending distally from the handle assembly and defining a longitudinal axis, a head portion disposed adjacent a distal portion of the elongated portion and comprising a cartridge assembly and an anvil assembly.
- a tissue-contacting surface of the cartridge assembly and a tissue-contacting surface of the anvil assembly define a tissue gap therebetween.
- the method also comprises rotating the handle assembly with respect to the elongated portion such that the cartridge assembly moves along the longitudinal axis with respect to the handle assembly, and affixing the handle assembly to the elongated portion to prevent future movement therebetween.
- the elongated portion threadably engages the handle assembly.
- the surgical instrument further comprises an approximation knob disposed in mechanical cooperation with the anvil assembly.
- the method further comprises rotating the approximation knob to cause longitudinal movement of the anvil assembly with respect to the cartridge assembly.
- the surgical instrument further comprises a drive member disposed in mechanical cooperation with the approximation knob and in mechanical cooperation with the anvil assembly, such that rotation of the approximation knob causes longitudinal translation of the drive member and longitudinal translation of the anvil assembly.
- the surgical instrument further comprises a stopper threadably engaged with a portion of the approximation knob. It is further disclosed that the method comprises rotating the stopper with respect to the approximation knob until a blocking portion of the stopper contacts a proximal face of the drive member. It is further disclosed that the method comprises affixing the stopper to the approximation knob to prevent future movement therebetween.
- FIGS. 1 and 2 are perspective views of the presently disclosed surgical instrument illustrated in an approximated position, in accordance with an embodiment of the present disclosure
- FIG. 3 is a side view of the surgical instrument of FIGS. 1 and 2 ;
- FIG. 4 is a top view of the surgical instrument of FIGS. 1-3 after the surgical instrument has been fired;
- FIG. 5 is an enlarged view of the area indicated in FIG. 4 ;
- FIG. 6 is a perspective view of a distal end of the surgical instrument of the present disclosure including a shipping wedge thereon;
- FIG. 7 is a perspective view of the shipping wedge of FIG. 6 ;
- FIG. 8 is a perspective view of a portion of the surgical instrument of the present disclosure with various parts removed;
- FIG. 9 is a perspective, assembly view of the surgical instrument of the present disclosure.
- FIG. 10 is a perspective, assembly view of parts of an elongated portion of the surgical instrument of the present disclosure.
- FIG. 11 is a perspective, assembly view of a shell assembly of the surgical instrument of the present disclosure.
- FIG. 12 is a perspective, assembly view of a drive assembly of the surgical instrument of the present disclosure.
- FIG. 13 is a perspective, assembly view of a pivot member of the surgical instrument of the present disclosure.
- FIG. 14 is a perspective, assembly view of a portion of the handle assembly of the surgical instrument of the present disclosure.
- FIG. 15 is a perspective, assembly view of an approximation mechanism of the surgical instrument of the present disclosure.
- FIG. 16 is a perspective, assembly view of an anvil assembly of the surgical instrument of the present disclosure.
- FIG. 17 is a perspective, assembly view of a movable handle of the surgical instrument of the present disclosure.
- FIG. 18 is a perspective view of the surgical instrument of the present disclosure with various parts removed, and illustrating a firing assembly in a locked position;
- FIG. 19 is an enlarged view of the area indicated in FIG. 18 ;
- FIG. 20 is a cross-sectional view of the surgical instrument of the present disclosure taken along line 20 - 20 in FIG. 18 ;
- FIG. 21 is an enlarged view of the area indicated in FIG. 20 ;
- FIG. 22 is a cross-section view of the surgical instrument of the present disclosure taken along line 22 - 22 in FIG. 4 ;
- FIG. 23 is a cross-section view of the surgical instrument of the present disclosure taken along line 23 - 23 in FIG. 22 ;
- FIG. 24 is an enlarged view of the area indicated in FIG. 22 ;
- FIG. 25 is an enlarged view of the area indicated in FIG. 22 ;
- FIG. 26 is a perspective view of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in a firing-enabled position;
- FIG. 27 is an enlarged view of a portion of the surgical instrument illustrated in FIG. 26 ;
- FIG. 28 is a proximal-looking transverse, cross-sectional view taken along line 28 - 28 in FIG. 22 ;
- FIG. 29 is a transverse, cross-sectional view taken along line 29 - 29 in FIG. 22 ;
- FIG. 30 is a proximal-looking transverse, cross-sectional view taken along line 30 - 30 in FIG. 22 ;
- FIG. 31 is an enlarged view of the area indicated in FIG. 22 illustrating a safety latch in a firing-enabled position
- FIG. 32 illustrates the safety latch of FIG. 31 in a locked position
- FIG. 33 is a perspective view of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in a firing-enabled position;
- FIG. 34 is an enlarged view of the area indicated in FIG. 33 ;
- FIG. 35 is a side view of portions of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in a firing-enabled position;
- FIG. 36 is a side view of portions of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in an actuated position.
- proximal will refer to the portion of the instrument closer to the operator and the term “distal” will refer to the portion of the instrument farther from the operator.
- FIGS. 1-36 illustrate an embodiment of the presently disclosed surgical instrument shown generally as 100 .
- surgical instrument 100 includes a handle assembly 200 , an elongated body portion 300 defining a longitudinal axis X-X, a head portion 400 , and a lockout mechanism 500 .
- the length, shape, curvature and/or diameter of elongated body portion 300 and head portion 400 may be varied to suit a particular surgical procedure.
- handle assembly 200 includes a stationary handle 210 , a movable handle 220 , and an approximation mechanism 250 .
- Head portion 400 includes a first jaw member (i.e., an anvil assembly 410 ) and a second jaw member (i.e., a shell assembly 420 ).
- Anvil assembly 410 is movable in relation to shell assembly 420 between spaced (e.g., FIGS. 18 and 20 ) and approximated positions (e.g., FIGS. 1, 2 and 22 ).
- Approximation mechanism 250 includes an approximation knob 252 and a drive member or drive screw 260 .
- Approximation knob 252 is mechanically engaged with drive screw 260
- a distal portion 262 of drive screw 260 is configured to mechanically engage an anvil retainer 412 ( FIG. 16 ).
- the proximal potion of drive screw 260 includes a helical channel 262 and is slidably positioned within a central bore 253 of a rotatable sleeve 254 ( FIG. 15 ), which extends distally from approximation knob 252 .
- a pin 256 extends through a hole 255 in a distal portion of sleeve 254 into helical channel 264 .
- Sleeve 254 is axially fixed with respect to stationary handle 210 .
- rotation of approximation knob 252 causes rotation of sleeve 254 , which causes pin 256 to move along channel 262 of drive screw 260 to effect axial movement of drive screw 260 , and thus a corresponding axial movement of anvil retainer 412 and anvil assembly 410 .
- rotation of approximation knob 252 causes movement of anvil assembly 410 in relation to shell assembly 420 between spaced and approximated positions
- rotation of approximation knob 252 in a first direction retracts anvil retainer 412 to cause proximal movement of anvil assembly 410 (i.e., toward shell assembly 420 ).
- Rotation of approximation knob 252 in a second opposite direction distally advances anvil retainer 412 to cause distal movement of anvil assembly 410 (i.e., away from shell assembly 420 ).
- Other approximation mechanisms are also contemplated. Further details of the approximation mechanism are described in U.S. Pat. No. 7,303,106, the entire contents of which are incorporated herein by reference.
- actuation of movable handle 220 i.e., pivoting in the direction of arrow “A” in FIG. 36 ), from its firing enabled position ( FIG. 35 ) to its actuated or fired position ( FIG. 36 ), causes fasteners or staples 450 ( FIG. 11 ) to be ejected from shell assembly 420 toward anvil assembly 410 .
- movable handle 220 is disposed in mechanical cooperation with a pusher 600 , such that actuation of movable handle 220 causes distal advancement of pusher 600 into direct or indirect contact with staples 450 , which causes ejection of staples 450 toward staple deforming pockets 411 ( FIG. 16 ) of anvil assembly 410 .
- a biasing element 610 urges pusher 600 proximally into contact with a camming surface 222 of movable handle 220 .
- a distal portion of biasing element 610 is in contact with a wall 202 ( FIG. 22 ) extending radially inwardly from an inner wall 204 of handle assembly 200 , thus enabling biasing element 610 to proximally bias pusher 600 .
- movable handle 220 is actuated, i.e. pivoted about a pivot member 223 , camming surface 222 of movable handle 220 is moved distally, camming a proximal portion of pusher 600 , which causes distal translation of pusher 600 and ejection of staples 450 . Further details of the actuation of the movable handle to cause ejection of staples is described in U.S. Pat. No. 7,303,106, incorporated by reference herein in its entirety.
- Locking mechanism 500 is configured to prevent premature ejection of staples from shell assembly 420 . Moreover, locking mechanism 500 prevents actuation of movable handle 220 until anvil assembly 410 has been moved into its approximated position with respect to shell assembly 420 .
- Locking mechanism 500 includes a slot 270 in drive screw 260 , and a pin 280 extending from a portion of movable handle 220 and which engages slot 270 .
- slot 270 includes a first, blocking portion 272 , and a second, firing portion 276 .
- pin 280 of movable handle is within blocking portion 272 of slot 270 .
- a user is prevented from actuating movable handle 220 in the direction of arrow “A,” because an attempt to do so would cause pin 280 to move in the direction of arrow “B” ( FIG. 19 ).
- pin 280 is unable to move in the direction of arrow “B” because pin 280 would be forced against a lower wall 273 of blocking portion 272 of slot 270 , thus preventing actuation of movable handle 220 .
- pin 280 of movable handle 220 is adjacent firing portion 276 of slot 270 . That is, drive screw 260 has been distally advanced via rotation of approximation knob 252 such that firing portion 276 of slot 270 of drive screw 260 is adjacent pin 280 of movable handle 220 .
- actuation of movable handle 220 by a user causes a gripping portion 224 of movable handle 220 to move in the direction of arrow “A” and causes pin 280 of movable handle 220 to move in the direction of arrow “B” into firing portion 276 of slot 270 .
- camming surface 222 of movable handle 220 is moved distally, camming a proximal portion of pusher 600 , which causes distal translation of pusher 600 and ejection of staples 450 .
- pin 280 of movable handle 220 when pin 280 of movable handle 220 is within firing portion 276 of slot 270 , drive screw 260 is physically prevented from longitudinal movement. That is, in this position, a user will be prevented from rotating approximation knob 252 , as the engagement between pin 280 and firing portion 276 of slot 270 of drive screw 260 would prevent longitudinal movement of drive screw 260 . More particularly, the engagement between pin 280 and a distal wall 277 of firing portion 276 of slot 270 would prevent drive screw 260 , and thus anvil assembly 410 , from proximally translating (see also FIGS. 35 and 36 ). The engagement between pin 280 and a proximal wall 278 of firing portion 276 of slot 270 would prevent drive screw 260 , and thus anvil assembly 410 , from distally translating.
- biasing element 610 urges pusher 600 and thus camming surface 222 of movable handle 220 proximally.
- Pin 280 is likewise moved proximally out of firing portion 276 of slot 270 , thus enabling longitudinal translation of drive screw 260 .
- slot 270 includes a transverse portion 279 disposed at the proximal-most end of slot 270 ( FIG. 27 ). It is envisioned that transverse portion 279 of slot 270 facilitates assembly of surgical instrument 100 . That is, during assembly, pin 280 of movable handle 220 is able to enter slot 270 through transverse portion 279 .
- surgical instrument includes a safety latch 650 disposed in mechanical cooperation with movable handle 220 .
- Safety latch 650 is another feature of surgical instrument 100 that is configured to maintain movable handle 220 in an open, non-actuated position until anvil assembly 410 and shell assembly 420 have been approximated.
- safety latch 650 is in the blocking position shown in FIG. 32 (wherein anvil assembly 410 and shell assembly 420 are in an unapproximated (spaced) position), movable handle 220 cannot be squeezed or actuated.
- safety latch 650 is in the enabling position shown in FIG.
- safety latch 650 is biased into its blocking position ( FIG. 32 ), and is movable by a user into its enabling position ( FIG. 31 ).
- safety latch 650 is an additional feature that may be included to help prevent staples from being fired prematurely by physically blocking movement of movable handle 220 .
- pusher 600 includes a proximal extension 620 .
- An outer perimeter of at least part of proximal extension 620 contacts an inner wall 204 of handle assembly 200 (see FIGS. 22 and 31 ). It is envisioned that proximal extension 620 of pusher 600 helps balance the forces enacted on drive screw 260 during firing of surgical instrument 100 . That is, the friction between inner wall 204 of handle assembly 200 and proximal extension 620 during longitudinal translation of drive screw 260 helps prevent drive screw 260 from twisting or torquing during firing.
- surgical instrument 100 includes an indicator 700 .
- Indicator 700 includes a first indicia 710 disposed adjacent a distal portion of drive screw 260 , a second indicia 720 disposed adjacent proximal extension 620 of pusher 600 , and a window 730 on handle assembly 200 .
- Indicator 700 is configured to enable a user determine whether staples 450 have been fired from shell assembly 420 . A user knows when staples 450 have been fired, when, as viewed through window 730 , first indicia 710 is longitudinally aligned with second indicia 720 .
- first indicia 710 is longitudinally aligned with second indicia 720 .
- first indicia 710 and second indicia 720 are longitudinally displaced from each other, movable handle 220 has not yet been actuated and thus no staples have been fired.
- first indicia 710 and second indicia 720 are longitudinally aligned, and thus indicates that surgical instrument 100 has been fired.
- Stopper 800 is threadably engaged with approximation knob 252 and is configured to ensure the position of drive screw 260 with respect to pin 280 of movable handle 220 .
- approximation knob 252 is rotated a sufficient amount that corresponds to firing position 276 of slot 270 being adjacent pin 280 .
- stopper 800 is rotated (e.g., advanced distally) until a blocking portion 802 stopper 800 makes contact with a proximal face 261 of drive screw 260 ( FIG. 25 ).
- stopper 800 engage threads 257 of approximation knob 252 to prevent future longitudinal movement of stopper 800 with respect to approximation knob 252 .
- drive screw 260 e.g., firing portion 276 of slot 270 therein
- surgical instrument 100 includes a tissue gap adjustment mechanism 900 .
- Tissue gap adjustment mechanism 900 enables altering the gap “G” between tissue-contacting surfaces of anvil assembly 410 and shell assembly 420 after assembly of surgical instrument 100 . Due in part to the build up of manufacturing tolerances, it is often cost prohibitive to achieve an exact or precise tissue gap “G” in an assembled surgical instrument. In the present disclosure, an exact tissue gap “G” can be achieved without the use of tighter or more strict manufacturing tolerances.
- Tissue gap adjustment mechanism 900 includes a first threaded portion 910 disposed adjacent a distal portion of handle assembly 200 , and a second threaded portion 920 disposed adjacent a proximal portion of elongated body portion 300 .
- First threaded portion 910 is configured to threadably engage second threaded portion 920 .
- handle assembly 200 is rotated with respect to elongated body portion 300 to increase or decrease the size of the tissue gap “G” by advancing or retracting shell assembly 420 .
- tissue gap adjustment mechanism 900 i.e., where handle assembly 200 and elongated body portion 300 meet
- tissue gap adjustment mechanism 900 is not limited to the location shown in the figures, but can be disposed in any reasonable location on surgical instrument 100 .
- FIGS. 6 and 7 illustrate a shipping wedge 950 .
- Shipping wedge 950 includes a first pair of tines 952 and a second pair of tines 954 .
- Tines 952 are configured to slidingly engage apertures 414 ( FIG. 16 ) on a distal end of anvil assembly 410 .
- Tines 954 are radially-outwardly flexible and are configured to releasably engage openings 422 ( FIG. 11 ) on an outer wall of shell assembly 420 . It is envisioned that shipping wedge 950 maintains anvil assembly 410 in a substantially fixed longitudinal position with respect to shell assembly 420 during shipping, storage, etc. of surgical instrument 100 .
- the present disclosure also relates to a method of performing a surgical procedure using surgical instrument 100 described herein, a method of manufacturing surgical instrument 100 described herein, a method of assembling surgical instrument 100 described herein, and a method of adjusting tissue gap “G” as described herein.
Abstract
Description
- This application is a Continuation Application of U.S. patent application Ser. No. 16/372,918, filed on Apr. 2, 2019, which is a Divisional Application of U.S. patent application Ser. No. 14/888,162, filed on Oct. 30, 2015, now U.S. Pat. No. 10,271,843, which is a National Stage Application of PCT/CN2013/077331, filed on Jun. 17, 2013, under § 371 (a), the entire disclosure of which is incorporated by reference herein.
- The present disclosure relates generally to a surgical fastening instrument for applying surgical fasteners to body tissue. More particularly, the present disclosure relates to a surgical fastening instrument that is locked out from firing fasteners until the cartridge assembly and anvil assembly are sufficiently approximated.
- Anastomosis is the surgical joining of separate hollow organ sections. Typically, an anastomosis procedure follows surgery in which a diseased or defective section of hollow tissue is removed and the remaining end sections are to be joined. Depending on the desired anastomosis procedure, the end sections may be joined by either circular, end-to-end or side-to-side organ reconstruction methods.
- In a circular anastomosis procedure, the two ends of the organ sections are joined by means of a stapling instrument which drives a circular array of staples or fasteners through the end section of each organ section and simultaneously cores any tissue interior of the driven circular array of staples to free the tubular passage. Examples of instruments for performing circular anastomosis of hollow organs are described for example in U.S. Pat. Nos. 7,303,106, 6,053,390, 5,588,579, 5,119,983, 5,005,749, 4,646,745, 4,576,167, and 4,473,077, each of which is incorporated herein in its entirety by reference. Typically, these instruments include an elongated shaft having a handle portion at a proximal end to actuate the instrument and a staple holding component disposed at a distal end. An anvil assembly including an anvil rod with an attached anvil head is mounted to the distal end of the instrument adjacent the staple holding component. Opposed end portions of tissue of the hollow organ(s) to be stapled are clamped between the anvil head and the staple holding component as these components are approximated. The clamped tissue is stapled by actuation of a trigger to drive one or more staples from the staple holding component so that the ends of the staples pass through the tissue and are deformed by the anvil head. An annular knife is concurrently advanced to core tissue within the hollow organ to free a tubular passage within the organ.
- Besides anastomosis of hollow organs, surgical stapling instruments for performing circular anastomosis have been used to treat internal hemorrhoids in the rectum. Typically, during use of a circular stapling instrument for hemorrhoid treatment, the anvil head and the staple holding component of the surgical stapling instrument are inserted through the anus and into the rectum with the anvil head and the staple holding component in an open or unapproximated position. Thereafter, a pursestring suture is used to pull the internal hemorrhoidal tissue towards the anvil rod. Next, the anvil head and the staple holding component are approximated to clamp the hemorrhoid tissue between the anvil head and the staple holding component. The stapling instrument is fired to remove the hemorrhoidal tissue and staple the cut tissue. In stapled hemorrhoidopexy, a strip of mucosa and submucosa at the top of the hemorrhoids is removed by the stapling instrument, thereby treating the hemorrhoids by inhibiting blood flow to the tissue.
- In certain situations, it is desirable to prevent premature firing of staples. Accordingly, it would be desirable for a surgical instrument to include a lockout mechanism that prevents the movable handle from being actuated until the anvil assembly and the cartridge assembly are sufficiently approximated.
- The present disclosure relates to a surgical instrument comprising a handle assembly, an elongated portion, a head portion, an approximation mechanism, and a lockout mechanism. The handle assembly comprises a movable handle and a stationary handle. The elongated portion extends distally from the handle assembly and defines a longitudinal axis. The head portion is disposed adjacent a distal portion of the elongated portion, and comprises a first jaw member and a second jaw member. The approximation mechanism comprises a drive member disposed in mechanical cooperation with the first jaw member and is configured to longitudinally move the first jaw member in relation to the second jaw member. The lockout mechanism is configured to selectively permit actuation of the movable handle to eject fasteners from the second jaw member. The lockout mechanism comprises a pin extending from the movable handle which is slidingly engaged with a slot in the drive member.
- In disclosed embodiments, actuation of the approximation mechanism causes longitudinal translation of the slot with respect to the pin.
- In disclosed embodiments, the slot in the drive member includes a blocking portion and a firing portion. When the pin is engaged with the blocking portion of the slot, the movable handle is prevented from being actuated, and when the pin is disposed between the blocking portion and the firing portion of the slot, the movable handle is able to be actuated. Here, it is disclosed that the pin is engaged between the blocking portion and the firing portion of the slot when the first jaw member and the second jaw member are in an approximated position. Here, it is disclosed that the pin is engaged with the firing portion of the slot during actuation of the movable handle. It is further disclosed that the firing portion of the slot is disposed distally adjacent the blocking portion of the slot. It is further disclosed that the blocking portion of the slot is substantially parallel to the longitudinal axis, and the firing portion of the slot is disposed at an angle with respect to the blocking portion of the slot. It is further disclosed that the firing portion of the slot is arcuate.
- In disclosed embodiments, the surgical instrument further comprises an approximation knob disposed adjacent a proximal portion of the drive member, and a stopper threadably engaged with a portion of the approximation knob. A blocking portion of the stopper is configured to contact a proximal face of the drive member.
- In disclosed embodiments, the handle assembly is threadably engaged with the elongated portion.
- The present disclosure also relates to a method of adjusting the minimum tissue gap between a cartridge assembly and an anvil assembly of a surgical instrument. The method comprises providing a surgical instrument comprising a handle assembly, an elongated portion extending distally from the handle assembly and defining a longitudinal axis, a head portion disposed adjacent a distal portion of the elongated portion and comprising a cartridge assembly and an anvil assembly. A tissue-contacting surface of the cartridge assembly and a tissue-contacting surface of the anvil assembly define a tissue gap therebetween. The method also comprises rotating the handle assembly with respect to the elongated portion such that the cartridge assembly moves along the longitudinal axis with respect to the handle assembly, and affixing the handle assembly to the elongated portion to prevent future movement therebetween.
- In disclosed embodiments, the elongated portion threadably engages the handle assembly.
- In disclosed embodiments, the surgical instrument further comprises an approximation knob disposed in mechanical cooperation with the anvil assembly. Here, the method further comprises rotating the approximation knob to cause longitudinal movement of the anvil assembly with respect to the cartridge assembly. Here, it is disclosed that the surgical instrument further comprises a drive member disposed in mechanical cooperation with the approximation knob and in mechanical cooperation with the anvil assembly, such that rotation of the approximation knob causes longitudinal translation of the drive member and longitudinal translation of the anvil assembly. Here, it is disclosed that the surgical instrument further comprises a stopper threadably engaged with a portion of the approximation knob. It is further disclosed that the method comprises rotating the stopper with respect to the approximation knob until a blocking portion of the stopper contacts a proximal face of the drive member. It is further disclosed that the method comprises affixing the stopper to the approximation knob to prevent future movement therebetween.
- Various embodiments of the presently disclosed surgical stapling instrument are disclosed herein with reference to the drawings, wherein:
-
FIGS. 1 and 2 are perspective views of the presently disclosed surgical instrument illustrated in an approximated position, in accordance with an embodiment of the present disclosure; -
FIG. 3 is a side view of the surgical instrument ofFIGS. 1 and 2 ; -
FIG. 4 is a top view of the surgical instrument ofFIGS. 1-3 after the surgical instrument has been fired; -
FIG. 5 is an enlarged view of the area indicated inFIG. 4 ; -
FIG. 6 is a perspective view of a distal end of the surgical instrument of the present disclosure including a shipping wedge thereon; -
FIG. 7 is a perspective view of the shipping wedge ofFIG. 6 ; -
FIG. 8 is a perspective view of a portion of the surgical instrument of the present disclosure with various parts removed; -
FIG. 9 is a perspective, assembly view of the surgical instrument of the present disclosure; -
FIG. 10 is a perspective, assembly view of parts of an elongated portion of the surgical instrument of the present disclosure; -
FIG. 11 is a perspective, assembly view of a shell assembly of the surgical instrument of the present disclosure; -
FIG. 12 is a perspective, assembly view of a drive assembly of the surgical instrument of the present disclosure; -
FIG. 13 is a perspective, assembly view of a pivot member of the surgical instrument of the present disclosure; -
FIG. 14 is a perspective, assembly view of a portion of the handle assembly of the surgical instrument of the present disclosure; -
FIG. 15 is a perspective, assembly view of an approximation mechanism of the surgical instrument of the present disclosure; -
FIG. 16 is a perspective, assembly view of an anvil assembly of the surgical instrument of the present disclosure; -
FIG. 17 is a perspective, assembly view of a movable handle of the surgical instrument of the present disclosure; -
FIG. 18 is a perspective view of the surgical instrument of the present disclosure with various parts removed, and illustrating a firing assembly in a locked position; -
FIG. 19 is an enlarged view of the area indicated inFIG. 18 ; -
FIG. 20 is a cross-sectional view of the surgical instrument of the present disclosure taken along line 20-20 inFIG. 18 ; -
FIG. 21 is an enlarged view of the area indicated inFIG. 20 ; -
FIG. 22 is a cross-section view of the surgical instrument of the present disclosure taken along line 22-22 inFIG. 4 ; -
FIG. 23 is a cross-section view of the surgical instrument of the present disclosure taken along line 23-23 inFIG. 22 ; -
FIG. 24 is an enlarged view of the area indicated inFIG. 22 ; -
FIG. 25 is an enlarged view of the area indicated inFIG. 22 ; -
FIG. 26 is a perspective view of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in a firing-enabled position; -
FIG. 27 is an enlarged view of a portion of the surgical instrument illustrated inFIG. 26 ; -
FIG. 28 is a proximal-looking transverse, cross-sectional view taken along line 28-28 inFIG. 22 ; -
FIG. 29 is a transverse, cross-sectional view taken along line 29-29 inFIG. 22 ; -
FIG. 30 is a proximal-looking transverse, cross-sectional view taken along line 30-30 inFIG. 22 ; -
FIG. 31 is an enlarged view of the area indicated inFIG. 22 illustrating a safety latch in a firing-enabled position; -
FIG. 32 illustrates the safety latch ofFIG. 31 in a locked position; -
FIG. 33 is a perspective view of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in a firing-enabled position; -
FIG. 34 is an enlarged view of the area indicated inFIG. 33 ; -
FIG. 35 is a side view of portions of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in a firing-enabled position; and -
FIG. 36 is a side view of portions of the surgical instrument of the present disclosure with various parts removed, and illustrating the firing assembly in an actuated position. - Embodiments of the presently disclosed surgical instrument will now be described in detail with reference to the drawings in which like reference numerals designate identical or corresponding elements in each of the several views. Throughout this description, the term “proximal” will refer to the portion of the instrument closer to the operator and the term “distal” will refer to the portion of the instrument farther from the operator.
-
FIGS. 1-36 illustrate an embodiment of the presently disclosed surgical instrument shown generally as 100. Briefly,surgical instrument 100 includes ahandle assembly 200, anelongated body portion 300 defining a longitudinal axis X-X, ahead portion 400, and alockout mechanism 500. The length, shape, curvature and/or diameter ofelongated body portion 300 andhead portion 400 may be varied to suit a particular surgical procedure. - With specific reference to
FIGS. 1-4 , handleassembly 200 includes astationary handle 210, amovable handle 220, and anapproximation mechanism 250.Head portion 400 includes a first jaw member (i.e., an anvil assembly 410) and a second jaw member (i.e., a shell assembly 420).Anvil assembly 410 is movable in relation toshell assembly 420 between spaced (e.g.,FIGS. 18 and 20 ) and approximated positions (e.g.,FIGS. 1, 2 and 22 ). - With reference to
FIGS. 9, 12, 15 and 18 , further details ofapproximation mechanism 250 are disclosed.Approximation mechanism 250 includes anapproximation knob 252 and a drive member or drivescrew 260.Approximation knob 252 is mechanically engaged withdrive screw 260, and adistal portion 262 ofdrive screw 260 is configured to mechanically engage an anvil retainer 412 (FIG. 16 ). The proximal potion ofdrive screw 260 includes ahelical channel 262 and is slidably positioned within acentral bore 253 of a rotatable sleeve 254 (FIG. 15 ), which extends distally fromapproximation knob 252. Apin 256 extends through ahole 255 in a distal portion ofsleeve 254 intohelical channel 264.Sleeve 254 is axially fixed with respect tostationary handle 210. Thus, rotation ofapproximation knob 252 causes rotation ofsleeve 254, which causespin 256 to move alongchannel 262 ofdrive screw 260 to effect axial movement ofdrive screw 260, and thus a corresponding axial movement ofanvil retainer 412 andanvil assembly 410. That is, rotation ofapproximation knob 252 causes movement ofanvil assembly 410 in relation toshell assembly 420 between spaced and approximated positions, More particularly, rotation ofapproximation knob 252 in a first direction (e.g., clockwise) retractsanvil retainer 412 to cause proximal movement of anvil assembly 410 (i.e., toward shell assembly 420). Rotation ofapproximation knob 252 in a second opposite direction (e.g., counter-clockwise) distally advancesanvil retainer 412 to cause distal movement of anvil assembly 410 (i.e., away from shell assembly 420). Other approximation mechanisms are also contemplated. Further details of the approximation mechanism are described in U.S. Pat. No. 7,303,106, the entire contents of which are incorporated herein by reference. - Referring now to
FIGS. 35 and 36 , actuation of movable handle 220 (i.e., pivoting in the direction of arrow “A” inFIG. 36 ), from its firing enabled position (FIG. 35 ) to its actuated or fired position (FIG. 36 ), causes fasteners or staples 450 (FIG. 11 ) to be ejected fromshell assembly 420 towardanvil assembly 410. That is,movable handle 220 is disposed in mechanical cooperation with apusher 600, such that actuation ofmovable handle 220 causes distal advancement ofpusher 600 into direct or indirect contact withstaples 450, which causes ejection ofstaples 450 toward staple deforming pockets 411 (FIG. 16 ) ofanvil assembly 410. More particularly, a biasingelement 610 urgespusher 600 proximally into contact with acamming surface 222 ofmovable handle 220. A distal portion of biasingelement 610 is in contact with a wall 202 (FIG. 22 ) extending radially inwardly from aninner wall 204 ofhandle assembly 200, thus enabling biasingelement 610 to proximallybias pusher 600. Whenmovable handle 220 is actuated, i.e. pivoted about apivot member 223,camming surface 222 ofmovable handle 220 is moved distally, camming a proximal portion ofpusher 600, which causes distal translation ofpusher 600 and ejection ofstaples 450. Further details of the actuation of the movable handle to cause ejection of staples is described in U.S. Pat. No. 7,303,106, incorporated by reference herein in its entirety. - Referring now to
FIGS. 12, 18, 19, 26, 27 and 33-36 ,lockout mechanism 500 ofsurgical instrument 100 is shown.Locking mechanism 500 is configured to prevent premature ejection of staples fromshell assembly 420. Moreover,locking mechanism 500 prevents actuation ofmovable handle 220 untilanvil assembly 410 has been moved into its approximated position with respect toshell assembly 420.Locking mechanism 500 includes aslot 270 indrive screw 260, and apin 280 extending from a portion ofmovable handle 220 and which engagesslot 270. With specific reference toFIG. 12 ,slot 270 includes a first, blockingportion 272, and a second, firingportion 276. - With specific reference to
FIG. 19 , prior to sufficient approximation ofanvil assembly 410, pin 280 of movable handle is within blockingportion 272 ofslot 270. In this position, a user is prevented from actuatingmovable handle 220 in the direction of arrow “A,” because an attempt to do so would causepin 280 to move in the direction of arrow “B” (FIG. 19 ). As shown,pin 280 is unable to move in the direction of arrow “B” becausepin 280 would be forced against alower wall 273 of blockingportion 272 ofslot 270, thus preventing actuation ofmovable handle 220. - Referring now to
FIG. 27 , after sufficient approximation ofanvil assembly 410, pin 280 ofmovable handle 220 isadjacent firing portion 276 ofslot 270. That is,drive screw 260 has been distally advanced via rotation ofapproximation knob 252 such that firingportion 276 ofslot 270 ofdrive screw 260 isadjacent pin 280 ofmovable handle 220. In this position, actuation ofmovable handle 220 by a user causes agripping portion 224 ofmovable handle 220 to move in the direction of arrow “A” and causespin 280 ofmovable handle 220 to move in the direction of arrow “B” into firingportion 276 ofslot 270. As discussed above, whenpin 280 ofmovable handle 220 moves into firingportion 276 ofslot 270,camming surface 222 ofmovable handle 220 is moved distally, camming a proximal portion ofpusher 600, which causes distal translation ofpusher 600 and ejection ofstaples 450. - Additionally, when
pin 280 ofmovable handle 220 is within firingportion 276 ofslot 270,drive screw 260 is physically prevented from longitudinal movement. That is, in this position, a user will be prevented from rotatingapproximation knob 252, as the engagement betweenpin 280 and firingportion 276 ofslot 270 ofdrive screw 260 would prevent longitudinal movement ofdrive screw 260. More particularly, the engagement betweenpin 280 and adistal wall 277 of firingportion 276 ofslot 270 would preventdrive screw 260, and thusanvil assembly 410, from proximally translating (see alsoFIGS. 35 and 36 ). The engagement betweenpin 280 and aproximal wall 278 of firingportion 276 ofslot 270 would preventdrive screw 260, and thusanvil assembly 410, from distally translating. - After
movable handle 220 is actuated to effect firing and the user releases the force againstmovable handle 220, biasingelement 610 urgespusher 600 and thuscamming surface 222 ofmovable handle 220 proximally.Pin 280 is likewise moved proximally out of firingportion 276 ofslot 270, thus enabling longitudinal translation ofdrive screw 260. - Additionally,
slot 270 includes atransverse portion 279 disposed at the proximal-most end of slot 270 (FIG. 27 ). It is envisioned thattransverse portion 279 ofslot 270 facilitates assembly ofsurgical instrument 100. That is, during assembly, pin 280 ofmovable handle 220 is able to enterslot 270 throughtransverse portion 279. - In the illustrated embodiments, and with particular reference to
FIGS. 31 and 32 , surgical instrument includes asafety latch 650 disposed in mechanical cooperation withmovable handle 220.Safety latch 650 is another feature ofsurgical instrument 100 that is configured to maintainmovable handle 220 in an open, non-actuated position untilanvil assembly 410 andshell assembly 420 have been approximated. Whensafety latch 650 is in the blocking position shown inFIG. 32 (whereinanvil assembly 410 andshell assembly 420 are in an unapproximated (spaced) position),movable handle 220 cannot be squeezed or actuated. Whensafety latch 650 is in the enabling position shown inFIG. 31 (whereinanvil assembly 410 andshell assembly 420 are in a closed position),movable handle 220 is able to be actuated. It is envisioned thatsafety latch 650 is biased into its blocking position (FIG. 32 ), and is movable by a user into its enabling position (FIG. 31 ). As can be appreciated,safety latch 650 is an additional feature that may be included to help prevent staples from being fired prematurely by physically blocking movement ofmovable handle 220. - As shown in
FIGS. 8 and 10 ,pusher 600 includes aproximal extension 620. An outer perimeter of at least part ofproximal extension 620 contacts aninner wall 204 of handle assembly 200 (seeFIGS. 22 and 31 ). It is envisioned thatproximal extension 620 ofpusher 600 helps balance the forces enacted ondrive screw 260 during firing ofsurgical instrument 100. That is, the friction betweeninner wall 204 ofhandle assembly 200 andproximal extension 620 during longitudinal translation ofdrive screw 260 helps preventdrive screw 260 from twisting or torquing during firing. - With particular reference to
FIGS. 5 and 34 ,surgical instrument 100 includes anindicator 700.Indicator 700 includes afirst indicia 710 disposed adjacent a distal portion ofdrive screw 260, asecond indicia 720 disposed adjacentproximal extension 620 ofpusher 600, and awindow 730 onhandle assembly 200.Indicator 700 is configured to enable a user determine whetherstaples 450 have been fired fromshell assembly 420. A user knows whenstaples 450 have been fired, when, as viewed throughwindow 730,first indicia 710 is longitudinally aligned withsecond indicia 720. InFIG. 34 , wherefirst indicia 710 andsecond indicia 720 are longitudinally displaced from each other,movable handle 220 has not yet been actuated and thus no staples have been fired. InFIG. 5 ,first indicia 710 andsecond indicia 720 are longitudinally aligned, and thus indicates thatsurgical instrument 100 has been fired. - With reference to
FIGS. 21 and 25 , astopper 800 is illustrated.Stopper 800 is threadably engaged withapproximation knob 252 and is configured to ensure the position ofdrive screw 260 with respect to pin 280 ofmovable handle 220. During assembly,approximation knob 252 is rotated a sufficient amount that corresponds to firingposition 276 ofslot 270 beingadjacent pin 280. Once this position is confirmed,stopper 800 is rotated (e.g., advanced distally) until a blockingportion 802stopper 800 makes contact with aproximal face 261 of drive screw 260 (FIG. 25 ). Next, during assembly, welding or a thread adhesive, for example, is used where thethreads 804 ofstopper 800 engagethreads 257 ofapproximation knob 252 to prevent future longitudinal movement ofstopper 800 with respect toapproximation knob 252. Whenstopper 800 is in this position and effectively affixed toapproximation knob 252, the proper positioning of drive screw 260 (e.g., firingportion 276 ofslot 270 therein) with respect to pin 280 is ensured. - Referring now to
FIG. 24 ,surgical instrument 100 includes a tissuegap adjustment mechanism 900. Tissuegap adjustment mechanism 900 enables altering the gap “G” between tissue-contacting surfaces ofanvil assembly 410 andshell assembly 420 after assembly ofsurgical instrument 100. Due in part to the build up of manufacturing tolerances, it is often cost prohibitive to achieve an exact or precise tissue gap “G” in an assembled surgical instrument. In the present disclosure, an exact tissue gap “G” can be achieved without the use of tighter or more strict manufacturing tolerances. - Tissue
gap adjustment mechanism 900 includes a first threadedportion 910 disposed adjacent a distal portion ofhandle assembly 200, and a second threadedportion 920 disposed adjacent a proximal portion ofelongated body portion 300. First threadedportion 910 is configured to threadably engage second threadedportion 920. After at least a partial assembly ofsurgical instrument 100, handleassembly 200 is rotated with respect toelongated body portion 300 to increase or decrease the size of the tissue gap “G” by advancing or retractingshell assembly 420. That is, whenhandle assembly 200 is rotated in a first direction about the longitudinal axis X-X with respect toelongated body portion 300,shell assembly 420 moves proximally with respect to handleassembly 200 and the tissue gap “G” increases, and whenhandle assembly 200 is rotated in a second direction about the longitudinal axis X-X with respect toelongated body portion 300,shell assembly 420 moves distally with respect to handleassembly 200 and the tissue gap “G” decreases. Once the desired tissue gap “G” is achieved, welding or a thread adhesive, for example, is used where first threadedportion 910 and second threadedportion 920 are engaged to prevent future longitudinal movement betweenhandle assembly 200 andelongated body portion 300. As can be appreciated, the location of tissue gap adjustment mechanism 900 (i.e., wherehandle assembly 200 andelongated body portion 300 meet) is not limited to the location shown in the figures, but can be disposed in any reasonable location onsurgical instrument 100. -
FIGS. 6 and 7 illustrate ashipping wedge 950.Shipping wedge 950 includes a first pair oftines 952 and a second pair oftines 954.Tines 952 are configured to slidingly engage apertures 414 (FIG. 16 ) on a distal end ofanvil assembly 410.Tines 954 are radially-outwardly flexible and are configured to releasably engage openings 422 (FIG. 11 ) on an outer wall ofshell assembly 420. It is envisioned thatshipping wedge 950 maintainsanvil assembly 410 in a substantially fixed longitudinal position with respect toshell assembly 420 during shipping, storage, etc. ofsurgical instrument 100. - The present disclosure also relates to a method of performing a surgical procedure using
surgical instrument 100 described herein, a method of manufacturingsurgical instrument 100 described herein, a method of assemblingsurgical instrument 100 described herein, and a method of adjusting tissue gap “G” as described herein. - It will be understood that various modifications may be made to the embodiments disclosed herein. Therefore, the above description should not be construed as limiting, but merely as exemplifications of disclosed embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto.
Claims (21)
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2013
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- 2013-06-17 EP EP13887355.9A patent/EP3010424A4/en not_active Withdrawn
- 2013-06-17 AU AU2013393223A patent/AU2013393223B2/en not_active Ceased
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US10271843B2 (en) | 2019-04-30 |
CA2911179A1 (en) | 2014-12-24 |
AU2013393223B2 (en) | 2018-10-25 |
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CN105636524B (en) | 2018-05-04 |
CN105636524A (en) | 2016-06-01 |
EP3010424A1 (en) | 2016-04-27 |
AU2018232991A1 (en) | 2018-10-11 |
US20190223866A1 (en) | 2019-07-25 |
WO2014201608A1 (en) | 2014-12-24 |
AU2018232991B2 (en) | 2020-01-16 |
AU2013393223A1 (en) | 2015-11-26 |
US11026679B2 (en) | 2021-06-08 |
US20160106418A1 (en) | 2016-04-21 |
CA2911179C (en) | 2022-03-29 |
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