US20210205800A1 - Ylide-functionalised phosphanes for use in metal complexes and homogeneous catalysis - Google Patents
Ylide-functionalised phosphanes for use in metal complexes and homogeneous catalysis Download PDFInfo
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- US20210205800A1 US20210205800A1 US17/152,365 US202117152365A US2021205800A1 US 20210205800 A1 US20210205800 A1 US 20210205800A1 US 202117152365 A US202117152365 A US 202117152365A US 2021205800 A1 US2021205800 A1 US 2021205800A1
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- metal
- aryl
- alkyl
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- 229910000064 phosphane Inorganic materials 0.000 title claims abstract description 99
- 229910052751 metal Inorganic materials 0.000 title claims description 81
- 239000002184 metal Substances 0.000 title claims description 81
- 150000003002 phosphanes Chemical class 0.000 title description 21
- 238000007172 homogeneous catalysis Methods 0.000 title description 6
- 239000003446 ligand Substances 0.000 claims abstract description 97
- 239000005922 Phosphane Substances 0.000 claims abstract description 78
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 claims abstract description 77
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 73
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 54
- 238000005859 coupling reaction Methods 0.000 claims description 47
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 38
- 125000003118 aryl group Chemical group 0.000 claims description 37
- 125000001072 heteroaryl group Chemical group 0.000 claims description 36
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 35
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 33
- 125000000524 functional group Chemical group 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 30
- 229910052723 transition metal Inorganic materials 0.000 claims description 29
- 125000004122 cyclic group Chemical group 0.000 claims description 27
- 150000003624 transition metals Chemical class 0.000 claims description 24
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 22
- 229910052763 palladium Inorganic materials 0.000 claims description 22
- 239000010970 precious metal Substances 0.000 claims description 21
- 230000008569 process Effects 0.000 claims description 21
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 20
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 18
- -1 1,3-diisopropylphenyl Chemical group 0.000 claims description 17
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 17
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 16
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 16
- 150000004696 coordination complex Chemical class 0.000 claims description 16
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 15
- 229910052737 gold Inorganic materials 0.000 claims description 15
- 239000010931 gold Substances 0.000 claims description 15
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 15
- 125000003342 alkenyl group Chemical group 0.000 claims description 14
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 125000006546 (C4-C10) cycloalkyl group Chemical group 0.000 claims description 13
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 13
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 12
- 229910052759 nickel Inorganic materials 0.000 claims description 12
- 239000000758 substrate Substances 0.000 claims description 12
- 125000005496 phosphonium group Chemical group 0.000 claims description 11
- UQRONKZLYKUEMO-UHFFFAOYSA-N 4-methyl-1-(2,4,6-trimethylphenyl)pent-4-en-2-one Chemical group CC(=C)CC(=O)Cc1c(C)cc(C)cc1C UQRONKZLYKUEMO-UHFFFAOYSA-N 0.000 claims description 10
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 10
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 claims description 10
- 229910052802 copper Inorganic materials 0.000 claims description 9
- 239000010949 copper Substances 0.000 claims description 9
- 229910052697 platinum Inorganic materials 0.000 claims description 9
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 8
- SPXOTSHWBDUUMT-UHFFFAOYSA-M 4-nitrobenzenesulfonate Chemical compound [O-][N+](=O)C1=CC=C(S([O-])(=O)=O)C=C1 SPXOTSHWBDUUMT-UHFFFAOYSA-M 0.000 claims description 8
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims description 8
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical group [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 8
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 8
- 230000008878 coupling Effects 0.000 claims description 8
- 239000007819 coupling partner Substances 0.000 claims description 8
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 8
- 239000011541 reaction mixture Substances 0.000 claims description 8
- 229910052709 silver Inorganic materials 0.000 claims description 8
- 239000004332 silver Substances 0.000 claims description 8
- 125000003396 thiol group Chemical class [H]S* 0.000 claims description 8
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 8
- 238000010168 coupling process Methods 0.000 claims description 7
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 6
- 125000002837 carbocyclic group Chemical group 0.000 claims description 6
- 230000000737 periodic effect Effects 0.000 claims description 6
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 6
- 125000004665 trialkylsilyl group Chemical group 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 3
- 150000001450 anions Chemical group 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000011737 fluorine Substances 0.000 claims description 3
- 229910052731 fluorine Inorganic materials 0.000 claims description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 abstract description 24
- 150000003623 transition metal compounds Chemical class 0.000 abstract description 7
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000006053 organic reaction Methods 0.000 abstract description 2
- 239000013256 coordination polymer Substances 0.000 description 96
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical group C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 87
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 62
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 61
- 230000003197 catalytic effect Effects 0.000 description 53
- 238000006243 chemical reaction Methods 0.000 description 46
- YMWUJEATGCHHMB-DICFDUPASA-N dichloromethane-d2 Chemical compound [2H]C([2H])(Cl)Cl YMWUJEATGCHHMB-DICFDUPASA-N 0.000 description 42
- 239000007787 solid Substances 0.000 description 39
- 238000002360 preparation method Methods 0.000 description 37
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 36
- 150000001345 alkine derivatives Chemical class 0.000 description 36
- 150000001336 alkenes Chemical class 0.000 description 32
- 239000000243 solution Substances 0.000 description 30
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 30
- 0 C[C-](C)C(C)C.[1*]P([2*])[Y].[1*]P([Y])[Y].[Y]P([Y])[Y] Chemical compound C[C-](C)C(C)C.[1*]P([2*])[Y].[1*]P([Y])[Y].[Y]P([Y])[Y] 0.000 description 29
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 26
- UHOVQNZJYSORNB-MZWXYZOWSA-N benzene-d6 Chemical compound [2H]C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H] UHOVQNZJYSORNB-MZWXYZOWSA-N 0.000 description 26
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 24
- 230000015572 biosynthetic process Effects 0.000 description 23
- 239000002904 solvent Substances 0.000 description 22
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 19
- WMKGGPCROCCUDY-PHEQNACWSA-N dibenzylideneacetone Chemical compound C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 WMKGGPCROCCUDY-PHEQNACWSA-N 0.000 description 18
- 150000003839 salts Chemical class 0.000 description 18
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 17
- 125000001424 substituent group Chemical group 0.000 description 17
- 238000003786 synthesis reaction Methods 0.000 description 17
- 238000005160 1H NMR spectroscopy Methods 0.000 description 16
- 238000000607 proton-decoupled 31P nuclear magnetic resonance spectroscopy Methods 0.000 description 16
- 150000001412 amines Chemical class 0.000 description 15
- 238000005913 hydroamination reaction Methods 0.000 description 15
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 14
- 239000000725 suspension Substances 0.000 description 14
- CYPYTURSJDMMMP-WVCUSYJESA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 CYPYTURSJDMMMP-WVCUSYJESA-N 0.000 description 13
- 239000002585 base Substances 0.000 description 13
- 229910052739 hydrogen Inorganic materials 0.000 description 13
- 239000001257 hydrogen Substances 0.000 description 13
- 239000000047 product Substances 0.000 description 13
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 12
- 150000002739 metals Chemical class 0.000 description 12
- 229910052760 oxygen Inorganic materials 0.000 description 11
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 10
- AFBPFSWMIHJQDM-UHFFFAOYSA-N N-methylaniline Chemical compound CNC1=CC=CC=C1 AFBPFSWMIHJQDM-UHFFFAOYSA-N 0.000 description 10
- 150000002902 organometallic compounds Chemical class 0.000 description 10
- 125000001831 (C6-C10) heteroaryl group Chemical group 0.000 description 9
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 9
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 9
- 125000005842 heteroatom Chemical group 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 229910052757 nitrogen Inorganic materials 0.000 description 9
- 229910052698 phosphorus Inorganic materials 0.000 description 9
- 229910052717 sulfur Inorganic materials 0.000 description 9
- RRKODOZNUZCUBN-CCAGOZQPSA-N (1z,3z)-cycloocta-1,3-diene Chemical compound C1CC\C=C/C=C\C1 RRKODOZNUZCUBN-CCAGOZQPSA-N 0.000 description 8
- NPDACUSDTOMAMK-UHFFFAOYSA-N 4-Chlorotoluene Chemical compound CC1=CC=C(Cl)C=C1 NPDACUSDTOMAMK-UHFFFAOYSA-N 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 8
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 8
- GWESVXSMPKAFAS-UHFFFAOYSA-N CC(C)C1CCCCC1 Chemical compound CC(C)C1CCCCC1 GWESVXSMPKAFAS-UHFFFAOYSA-N 0.000 description 8
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- 238000005481 NMR spectroscopy Methods 0.000 description 8
- 125000001931 aliphatic group Chemical group 0.000 description 8
- 229910002091 carbon monoxide Inorganic materials 0.000 description 8
- 238000006555 catalytic reaction Methods 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 8
- 238000006880 cross-coupling reaction Methods 0.000 description 8
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 8
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 8
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 8
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 8
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 8
- 238000003477 Sonogashira cross-coupling reaction Methods 0.000 description 7
- 238000006069 Suzuki reaction reaction Methods 0.000 description 7
- 238000007259 addition reaction Methods 0.000 description 7
- 150000001491 aromatic compounds Chemical class 0.000 description 7
- 150000005347 biaryls Chemical class 0.000 description 7
- 238000010537 deprotonation reaction Methods 0.000 description 7
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 7
- 125000004437 phosphorous atom Chemical group 0.000 description 7
- 125000004076 pyridyl group Chemical group 0.000 description 7
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium group Chemical group [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 6
- 230000005595 deprotonation Effects 0.000 description 6
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 6
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 6
- MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 6
- RAOIDOHSFRTOEL-UHFFFAOYSA-N tetrahydrothiophene Chemical compound C1CCSC1 RAOIDOHSFRTOEL-UHFFFAOYSA-N 0.000 description 6
- 238000004009 13C{1H}-NMR spectroscopy Methods 0.000 description 5
- 238000007792 addition Methods 0.000 description 5
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 description 5
- USJRLGNYCQWLPF-UHFFFAOYSA-N chlorophosphane Chemical compound ClP USJRLGNYCQWLPF-UHFFFAOYSA-N 0.000 description 5
- FDWREHZXQUYJFJ-UHFFFAOYSA-M gold monochloride Chemical compound [Cl-].[Au+] FDWREHZXQUYJFJ-UHFFFAOYSA-M 0.000 description 5
- 150000002900 organolithium compounds Chemical class 0.000 description 5
- 238000007358 phosphanylation reaction Methods 0.000 description 5
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 5
- JIWDQJYCCQFDAF-UHFFFAOYSA-N potassium;2-methylpropan-2-olate;oxolane Chemical compound [K+].CC(C)(C)[O-].C1CCOC1 JIWDQJYCCQFDAF-UHFFFAOYSA-N 0.000 description 5
- 239000002243 precursor Substances 0.000 description 5
- 125000005537 sulfoxonium group Chemical group 0.000 description 5
- YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 5
- QSSXJPIWXQTSIX-UHFFFAOYSA-N 1-bromo-2-methylbenzene Chemical compound CC1=CC=CC=C1Br QSSXJPIWXQTSIX-UHFFFAOYSA-N 0.000 description 4
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 4
- UEXCJVNBTNXOEH-UHFFFAOYSA-N Ethynylbenzene Chemical group C#CC1=CC=CC=C1 UEXCJVNBTNXOEH-UHFFFAOYSA-N 0.000 description 4
- 229910003771 Gold(I) chloride Inorganic materials 0.000 description 4
- 150000001500 aryl chlorides Chemical class 0.000 description 4
- 150000001502 aryl halides Chemical class 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- LWNLXVXSCCLRRZ-UHFFFAOYSA-N dichlorophosphane Chemical class ClPCl LWNLXVXSCCLRRZ-UHFFFAOYSA-N 0.000 description 4
- HDULBKVLSJEMGN-UHFFFAOYSA-N dicyclohexylphosphane Chemical compound C1CCCCC1PC1CCCCC1 HDULBKVLSJEMGN-UHFFFAOYSA-N 0.000 description 4
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 4
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- SLAFUPJSGFVWPP-UHFFFAOYSA-M ethyl(triphenyl)phosphanium;iodide Chemical compound [I-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CC)C1=CC=CC=C1 SLAFUPJSGFVWPP-UHFFFAOYSA-M 0.000 description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 4
- 238000011065 in-situ storage Methods 0.000 description 4
- 125000002524 organometallic group Chemical group 0.000 description 4
- WYURNTSHIVDZCO-SVYQBANQSA-N oxolane-d8 Chemical compound [2H]C1([2H])OC([2H])([2H])C([2H])([2H])C1([2H])[2H] WYURNTSHIVDZCO-SVYQBANQSA-N 0.000 description 4
- 125000005440 p-toluyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C(*)=O)C([H])([H])[H] 0.000 description 4
- PENAXHPKEVTBLF-UHFFFAOYSA-L palladium(2+);prop-1-ene;dichloride Chemical compound [Pd+]Cl.[Pd+]Cl.[CH2-]C=C.[CH2-]C=C PENAXHPKEVTBLF-UHFFFAOYSA-L 0.000 description 4
- 238000004983 proton decoupled 13C NMR spectroscopy Methods 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- VSASBVHRJMFNEO-UHFFFAOYSA-M tricyclohexyl(ethyl)phosphanium;iodide Chemical compound [I-].C1CCCCC1[P+](C1CCCCC1)(CC)C1CCCCC1 VSASBVHRJMFNEO-UHFFFAOYSA-M 0.000 description 4
- YWWDBCBWQNCYNR-UHFFFAOYSA-O trimethylphosphanium Chemical compound C[PH+](C)C YWWDBCBWQNCYNR-UHFFFAOYSA-O 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-O triphenylphosphanium Chemical compound C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-O 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- GETTZEONDQJALK-UHFFFAOYSA-N (trifluoromethyl)benzene Chemical compound FC(F)(F)C1=CC=CC=C1 GETTZEONDQJALK-UHFFFAOYSA-N 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
- 150000001499 aryl bromides Chemical class 0.000 description 3
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 150000001805 chlorine compounds Chemical class 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 150000002390 heteroarenes Chemical class 0.000 description 3
- DLEDOFVPSDKWEF-UHFFFAOYSA-N lithium butane Chemical compound [Li+].CCC[CH2-] DLEDOFVPSDKWEF-UHFFFAOYSA-N 0.000 description 3
- MZRVEZGGRBJDDB-UHFFFAOYSA-N n-Butyllithium Substances [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 3
- 150000002940 palladium Chemical class 0.000 description 3
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- 230000007704 transition Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
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- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
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- C07F1/12—Gold compounds
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- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
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- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/30—Addition reactions at carbon centres, i.e. to either C-C or C-X multiple bonds
- B01J2231/32—Addition reactions to C=C or C-C triple bonds
- B01J2231/321—Hydroformylation, metalformylation, carbonylation or hydroaminomethylation
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- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4205—C-C cross-coupling, e.g. metal catalyzed or Friedel-Crafts type
- B01J2231/4211—Suzuki-type, i.e. RY + R'B(OR)2, in which R, R' are optionally substituted alkyl, alkenyl, aryl, acyl and Y is the leaving group
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- B01J2231/40—Substitution reactions at carbon centres, e.g. C-C or C-X, i.e. carbon-hetero atom, cross-coupling, C-H activation or ring-opening reactions
- B01J2231/42—Catalytic cross-coupling, i.e. connection of previously not connected C-atoms or C- and X-atoms without rearrangement
- B01J2231/4277—C-X Cross-coupling, e.g. nucleophilic aromatic amination, alkoxylation or analogues
- B01J2231/4283—C-X Cross-coupling, e.g. nucleophilic aromatic amination, alkoxylation or analogues using N nucleophiles, e.g. Buchwald-Hartwig amination
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- B01J2531/0202—Polynuclearity
- B01J2531/0205—Bi- or polynuclear complexes, i.e. comprising two or more metal coordination centres, without metal-metal bonds, e.g. Cp(Lx)Zr-imidazole-Zr(Lx)Cp
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- B01J2531/10—Complexes comprising metals of Group I (IA or IB) as the central metal
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- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
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- B01J2540/50—Non-coordinating groups comprising phosphorus
- B01J2540/54—Quaternary phosphonium groups
Definitions
- the invention relates to ylide-functionalized phosphane ligands, the preparation thereof, and the use thereof in transition metal compounds, and the use thereof as catalysts in organic reactions.
- Phosphanes are among the most frequently used ligands in catalysis. Adjusting their electronic and steric parameters is critical to increase the activity of a catalyst, to determine selectivities, and to be able to enlarge the substrate diversity (A. C. Hillier et al., Organometallics, 22: 4322 (2003); H. Clavier et al. Chem. Commun., 46: 841 (2010); Z. L. Niemeyer, A. Milo, D. P. Hickey, M. S. Sigman, Nature Chem. 8: 610 (2016); C. A. Tolman, Chem. Rev. 77, 313 (1977); G. Frenking, Organometallics, 28, 3901 (2009)).
- phosphanes are employed in a wide variety of reactions, such as palladium-catalyzed coupling reactions (M. A. WOnsche et al., Angew. Chem. Int. Ed., 54, 11857 (2015); D. S. Surry et al., Angew. Chem. Int. Ed., 47, 6338 (2008); R. Martin et al., Acc. Chem. Res., 41, 1461 (2008); S.
- Novel active catalyst systems are based on, inter alia, adamantyl-functionalized phosphanes (DE-A-10037961, WO 02/10178, L. Chen et al., J. Am. Chem. Soc., 138, 6392 (2016); C. A.
- Ligand design is decisive in catalysis to enable reactions, or to be able to direct them into desired directions.
- the development of new phosphane ligands is often required to realize more cost-effective starting substrates (e.g., chlorides instead of iodides), higher catalyst productivities and activities, and a broader substrate and reaction diversity.
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- on is selected from phosphonium groups —P(R 3 R 4 R 5 ), ammonium groups —N(R 3 R 4 R 5 ), sulfoxonium groups —SOR 3 R 4 and sulfonium groups —S(R 3 R 4 ),
- X independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR 3 R 4 R 5 ), sulfonyl (—SO 2 R 3 ), phosphoryl (—P(O)R 3 R 4 , —P(S)R 3 R 4 , —P(NR 3 )R 4 R 5 2 ), cyano (—CN), alkoxy (—OR 3 ) and amino (—NR 3 R 4 ) groups, and
- R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups, with the proviso that R 1 and R 2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R 1 and R 2 are not phenyl if X is p-toluylsulfonyl (—SO 2 (p-toluyl)) and Z is triphenylphosphonium.
- the alkyl groups are selected from linear, branched-chain or cyclic C 1-10 alkyl groups, preferably from C 1-6 alkyl groups or C 4-10 -cycloalkyl groups
- the aryl groups are selected from C 6-14 aryl groups, preferably from C 6-10 aryl groups
- the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C 2-10 alkenyl groups, preferably from C 2-6 alkenyl groups
- the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S; and/or
- the functional groups are selected from alkyl (—R 11 ), especially C 1-6 alkyl groups, C 6-10 aryl (—R 12 ), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR 3 ), amino (—NR 11 2 , —NHR 11 , —NH 2 ), mercapto (—SH, —SR 11 ), wherein R 11 , independently of further R 11 residues, is selected from C 1-6 alkyl residues.
- On is a phosphonium group —P(R 3 R 4 R 5 ), in which R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C 1-6 alkyl groups, C 6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C 2-6 alkenyl groups, a trialkylsilyl (—SiR 3 R 4 R 5 ), arylsulfonyl (R 12 —SO 2 R 3 ) group, and R 1 and R 2 are C 6-10 aryl groups or C 1-6 alkyl and cycloalkyl groups.
- R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups
- R 3 , R 4 and R 5 are independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof.
- R 3 , R 4 and R 5 are the same and are selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- X is selected from the group consisting of methyl, ethyl, cyclohexyl, phenyl, p-tolyl, trimethylsilyl, p-tolylsulfonyl, or combinations thereof.
- R 1 and R 2 are independently selected from the group consisting of phenyl, cyclohexyl, methyl, and combinations thereof.
- metal complexes or metal salts are precious metal or transition metal complexes or precious metal or transition metal compounds.
- phosphane ligands according to any of items 1 to 7 in combination with metal, precious metal or transition metal complexes or metal, precious metal or transition metal salts as catalysts, wherein the ligands are added to the metal, precious metal or transition metal precursor compounds in situ, or the isolated metal, precious metal or transition metal complexes of the phosphane ligands according to aspect (3) are employed.
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- on is selected from phosphonium groups —P(R 3 R 4 R 5 ), ammonium groups —N(R 3 R 4 R 5 ), sulfonium groups —SOR 3 R 4 and sulfonium groups —S(R 3 R 4 ),
- X independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR 3 3 R 4 R 5 ), sulfonyl (—SO 2 R 3 ), phosphoryl (—P(O)R 3 R 4 , —P(S)R 3 R 4 , —P(NR 3 )R 4 R 5 2 ), cyano (—CN), alkoxy (—OR) and amino (—NR 2 ) groups, and
- R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups, with the proviso that R 1 and R 2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R 1 and R 2 are not phenyl if X is p-toluylsulfonyl (—SO 2 (p-toluyl)) and Z is triphenylphosphonium.
- the alkyl groups are selected from linear, branched-chain or cyclic C 1-10 alkyl groups, preferably from C 1-6 alkyl groups or C 4-10 -cycloalkyl groups
- the aryl groups are selected from C 6-14 aryl groups, preferably from C 6-10 aryl groups
- the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C 2-10 alkenyl groups, preferably from C 2-6 alkenyl groups
- the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S
- the functional groups are selected from alkyl (—R 11 ), especially C 1-6 alkyl groups, C 6-10 aryl (—R 12 ), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR 3
- On is a phosphonium group —P(R 3 R 4 R 5 ), in which R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C 1-6 alkyl groups, C 6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C 2-6 alkenyl groups, a trialkylsilyl (—SiR 3 R 4 R 5 ), arylsulfonyl (R 12 —SO 2 R 3 ) group, and R 1 and R 2 are C 6-10 aryl groups or C 1-6 alkyl and cycloalkyl groups.
- R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups
- R 3 , R 4 and R 5 are independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof.
- R 3 , R 4 and R 5 are the same and are selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- R 1 and R 2 are independently selected from the group consisting of phenyl, cyclohexyl, methyl, tert-butyl and combinations thereof.
- R 33 , R 34 and R 35 are independently selected from H, alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups; or
- R 33 , R 34 and R 35 form a carbocyclic ring with 5 to 14 carbon atoms
- Ar represents a substituted or unsubstituted, especially a substituted, aryl group.
- R 33 , R 34 and R 35 are independently selected from linear, branched-chain or cyclic C 1-10 alkyl groups, preferably from C 1-6 alkyl groups or C 4-10 -cycloalkyl groups
- the aryl groups are selected from C 6-14 aryl groups, preferably from C 6-10 aryl groups
- the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C 2-10 alkenyl groups, preferably from C 2-6 alkenyl groups
- the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and/or
- R 33 , R 34 and R 35 form a carbocyclic ring that is a C 4-10 cycloalkyl group, or a C 6-14 aryl group, which may be substituted with one or more functional groups;
- Ar are selected from C 6-14 aryl groups, preferably C 6-10 aryl groups, and the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and
- the functional groups are selected from alkyl (—R 11 ), especially C 1-6 alkyl groups, C 6-10 aryl (—R 12 ), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR 3 ), amino (—NR 11 2 , —NHR 11 , —NH 2 ), mercapto (—SH, —SR 11 ), wherein R 11 , independently of further R 11 residues, is selected from C 1-6 alkyl residues.
- X is selected from the group of fluorine, chlorine, bromine, iodine, tosylate, nosylate and mesylate, and/or aryl is selected from phenyl, m-tolyl, p-tolyl, o-tolyl, mesityl, 1,3-diisopropylphenyl.
- organometallic compound is selected from the group consisting of organic boron compounds, organolithium compounds, organozinc compounds, organolithium compounds, and Grignard compounds.
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- on independently of the onium groups in other ylide substituents, is selected from phosphonium groups —PRR′ 2 , ammonium groups —NRR′ 2 , sulfoxonium groups —SOR 2 and sulfonium groups —SRR′,
- X independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR 3 ), sulfonyl (—SO 2 R), phosphoryl (—P(O)R 2 , —P(S)R 2 , —P(NR)R 2 ), cyano (—CN), alkoxy (—OR) and amino groups (—NR 2 ), and
- R and R′ are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups;
- Aspect (1) of the invention provides phosphane ligands of formulas YPRR′ (I), Y 2 PR (II) and Y 3 P (III).
- R and R′ represent alkyl, aryl and heteroaromatic residues with and without further functional groups (e.g., amines, ethers).
- On describes a substituent with a positive charge, such as onium groups, mainly phosphonium groups —PRR′ 2 , ammonium —NRR′ 2 , sulfoxonium groups —SOR 2 , or sulfonium groups —SRR′.
- onium groups mainly phosphonium groups —PRR′ 2 , ammonium —NRR′ 2 , sulfoxonium groups —SOR 2 , or sulfonium groups —SRR′.
- the carbon atom directly bound to the phosphorus atom formally bears a negative charge.
- the alkyl groups are selected from linear, branched-chain or cyclic C 1-10 alkyl groups, preferably from C 1-6 alkyl groups
- the aryl groups are selected from C 6-14 aryl groups, preferably from C 6-10 aryl groups
- the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C 2-10 alkenyl groups, preferably from C 2-6 alkenyl groups
- the heteroaryl groups are selected from C 4-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from B, N, O and S.
- the phosphanes may also be doubly and triply ylide-substituted to obtain phosphanes of formulas (II) Y 2 PR and (III) Y 3 P.
- a preferred embodiment of aspect (1) are phosphane ligands of formula (I)
- On is a triarylphosphonium group, especially a triphenylphosphonium group
- X is a trialkylsilyl, cyano (—CN), methyl or arylsulfonyl group, especially a trimethylsilyl or p-tolylsulfonyl group
- R and R′ are aryl or alkyl groups, especially phenyl, cyclohexyl or methyl groups.
- Aspect (2) of this invention relates to the preparation of the ylide-functionalized phosphane ligands according to the invention. They can be prepared via two alternative synthetic pathways, which allows for a broad variation of the substitution pattern: The synthesis can be achieved either through an a-metallated ylide, which is reacted with a corresponding chlorophosphane (route A), or through the a-deprotonation of an a-phosphanyl-substituted phosphonium salt (route B).
- the a-metallated ylides required for route A can be prepared by the deprotonation of classical ylides with metal bases, such as organolithium compounds or alkali metal amides (T. Scherpf et al., Angew. Chem. Int. Ed., 54, 8542 (2015); Bestmann, H. J. et al.; Angew. Chem. Int. Ed., 26, 79 (1987)).
- ylide-functionalized chlorophosphanes of the type YPCl 2 can also be prepared, which can be reacted in a further step with organometallic reagents (or organolithium, organomagnesium and organozinc reagents) to form an alkyl/aryl phosphane.
- organometallic reagents or organolithium, organomagnesium and organozinc reagents
- Reactions of chlorophosphanes with metal bases are described, for example, in Houben-Weyl, Methoden der organischen Chemie, 1963, volume XII, 1 S33.
- the use of phosphorus trichloride and dichlorophosphanes also enables access to multiply ylide-substituted phosphanes.
- Route B is a practical alternative to route A, which circumvents the isolation of sensitive metallated intermediates. Proceeding from a classical onium salts, the introduction of the phosphane moiety is effected by using a halophosphane in the presence of a base. When an excess of base is used, the formation of the ylide-functionalized phosphane is achieved on a direct route. Thus, this method allows for the preparation of the ligands from readily available starting substances or from commercially available precursors.
- the novel phosphanes are reacted with transition metal compounds to form the corresponding complexes, such as with compounds of the metals Ni, Pd, Pt, Rh, Ir, Cu and Au.
- the complexes can be either isolated as solids, or generated in situ and used further for catalytic applications.
- the phosphane ligands prove to be very strong donor ligands whose donor capabilities exceeds that of classical phosphane ligands.
- TEP Tolman parameter
- transition metal complexes of the ylide-functionalized phosphane ligands are employed in different homogeneously catalyzed reactions, such as in palladium-catalyzed coupling reactions (e.g., C—C—, C—O, C—N couplings), and gold-catalyzed hydroamination reactions. In these reactions, they exhibit extraordinarily high activities that exceed those of analogous complexes with common phosphane ligands. Thus, in the gold-catalyzed hydroamination of alkynes, high conversion rates are observed already at room temperature. In part, TONs of more than 10,000 are achieved. Analogous reactions with other phosphane ligands usually require higher reaction temperatures of further additions of additives (D.
- the invention relates to phosphane ligands of formulas YPRR 2 (I), Y 2 PR 1 (II) and Y 3 P (III)
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- on is selected from phosphonium groups —P(R 3 R 4 R 5 ), ammonium groups —N(R 3 R 4 R 5 ), sulfoxonium groups —SOR 3 R 4 and sulfonium groups —S(R 3 R 4 ),
- X independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR 3 R 4 R 5 ), sulfonyl (—SO 2 R 3 ), phosphoryl (—P(O)R 3 R 4 , —P(S)R 3 R 4 , —P(NR 3 )R 4 R 5 2 ), cyano (—CN), alkoxy (—OR 3 ) and amino (—NR 3 R 4 ) groups, and
- R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups;
- R 1 and R 2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R 1 and R 2 are not phenyl if X is p-toluylsulfonyl (—SO 2 (p-toluyl)) and Z is triphenylphosphonium.
- the alkyl groups are selected from linear, branched-chain or cyclic C 1-10 alkyl groups, preferably from C 1-6 alkyl groups
- the aryl groups are selected from C 6-14 aryl groups, preferably from C 6-10 aryl groups
- the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C 2-10 alkenyl groups, preferably from C 2-6 alkenyl groups
- the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from B, N, O and S, and/or
- a specific embodiment relates to phosphane ligands represented by formula (I) or (II)
- On is a phosphonium group —P(R 3 R 4 R 5 ), in which R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C 1-6 alkyl groups, C 6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C 2-6 alkenyl groups, a trialkylsilyl (—SiR 3 R 4 R 5 ), arylsulfonyl (R 12 —SO 2 R 3 ) group, and R 1 and R 2 are C 6-10 aryl groups or C 1-6 alkyl and cycloalkyl groups.
- R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups
- R 3 , R 4 and R 5 may be independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof.
- R 3 , R 4 and R 5 may be the same and selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- X may be selected from the group consisting of methyl, ethyl, cyclohexyl, phenyl, p-tolyl, trimethylsilyl, p-tolylsulfonyl, or combinations thereof.
- R 1 and R 2 may be independently selected from the group consisting of phenyl, cyclohexyl, methyl, and combinations thereof.
- Another embodiment relates to a process for preparing the phosphane ligands, comprising
- the phosphane ligands may be used in the synthesis of metal complexes or metal salts.
- these may be precious metal or transition metal complexes or precious metal or transition metal compounds.
- metals of group 10 or 11 of the Periodic Table of the elements may be employed.
- the metal, precious metal or transition metal complexes and salts with the phosphane ligands as described above may be employed in homogeneous catalysis.
- the phosphane ligands according to aspect (3) may be employed in combination with metal, precious metal or transition metal complexes or metal, precious metal or transition metal salts as catalysts, wherein the ligands are added to the metal, precious metal or transition metal precursor compounds in situ, or the isolated metal, precious metal or transition metal complexes of the phosphane ligands according to aspect (3) may be employed in the synthesis of transition metal complexes or transition metal salts.
- the metals platinum, palladium and nickel, preferably palladium may be used in another embodiment, the metals copper, silver and gold, preferably gold, may be used.
- the ligands may be employed
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- on is selected from phosphonium groups —P(R 3 R 4 R 5 ), ammonium groups —N(R 3 R 4 R 5 ), sulfoxonium groups —SOR 3 R 4 and sulfonium groups —S(R 3 R 4 ),
- X independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR 3 3 R 4 R 5 ), sulfonyl (—SO 2 R 3 ), phosphoryl (—P(O)R 3 R 4 , —P(S)R 3 R 4 , —P(NR 3 )R 4 R 5 2 ), cyano (—CN), alkoxy (—OR 3 ) and amino (—NR 3 R 4 ) groups, and
- R 1 , R 2 , R 3 , R 4 and R 5 are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups, with the proviso that R 1 and R 2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R 1 and R 2 are not phenyl if X is p-toluylsulfonyl (—SO 2 (p-toluyl)) and Z is triphenylphosphonium.
- the alkyl groups may be selected from linear, branched-chain or cyclic C 1-10 alkyl groups, preferably from C 1-6 alkyl groups or C 4-10 -cycloalkyl groups, the aryl groups are selected from C 6-14 aryl groups, preferably from C 6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C 2-10 alkenyl groups, preferably from C 2-6 alkenyl groups, and the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S; and/or
- the functional groups are selected from alkyl (—R 11 ), especially C 1-6 alkyl groups, C 6-10 aryl (—R 12 ), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR 3 ), amino (—NR 11 2 , —NHR 11 , —NH 2 ), mercapto (—SH, —SR 11 ), wherein R 11 , independently of further R 11 residues, is selected from C 1-6 alkyl residues.
- the metal complexes may be, in particular, precious metal or transition metal complexes or precious metal or transition metal compounds.
- metals of group 10 or 11 of the Periodic Table of Elements may be employed.
- the metals platinum, palladium and nickel, preferably palladium may be used.
- the metals copper, silver and gold, preferably gold may be used.
- these may be metal complexes having phosphane ligands of formula (I) or (II)
- On is a phosphonium group —P(R 3 R 4 R 5 ), in which R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C 1-6 alkyl groups, C 6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C 2-6 alkenyl groups, a trialkylsilyl (—SiR 3 R 4 R 5 ), arylsulfonyl (R 12 —SO 2 R 3 ) group, and R 1 and R 2 are C 6-10 aryl groups or C 1-6 alkyl and cycloalkyl groups.
- R 3 , R 4 and R 5 are independently selected from the group consisting of C 1-6 alkyl groups, C 4-10 cycloalkyl groups, C 6-10 aryl groups
- R 3 , R 4 and R 5 may be independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, or R 3 , R 4 and R 5 may be the same and be selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- X may be selected from the group consisting of methyl, ethyl, cyclohexyl, phenyl, p-tolyl, trimethylsilyl, p-tolylsulfonyl, or combinations thereof.
- Advantageous ligands may be, in particular, ligands of the above formulas (I) or (II) with the substituents according to the following Table 1:
- PPh3 represents triphenylphosphine
- PCy3 represents tricyclohexylphosphine.
- the metal complexes may be, in particular, precious metal or transition metal complexes or precious metal or transition metal compounds.
- metals of group 10 or 11 of the Periodic Table of Elements may be employed.
- the metals platinum, palladium and nickel, preferably palladium may be used.
- the metal complexes may also have further ligands, such as neutral electron donor ligands, for example, dibenzylideneacetone (DBA), carbon monoxide CO, NHC ligands, phosphines, such as triphenylphosphine or tricyclohexylphosphine, and amines, such as triethylamine or tributylamine.
- ligands such as neutral electron donor ligands, for example, dibenzylideneacetone (DBA), carbon monoxide CO, NHC ligands, phosphines, such as triphenylphosphine or tricyclohexylphosphine, and amines, such as triethylamine or tributylamine.
- charged ligands such as halogens, especially chloride, bromide and iodide, or the pseudohalides mesylate, triflate, acetate, may be present.
- the metal complexes may additionally include, in particular, ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- DBA dibenzylideneacetone
- CO carbon monoxide CO
- triphenylphosphine tricyclohexylphosphine
- triethylamine triethylamine
- tributylamine tributylamine
- pyridyl chloride, bromide, iodide, mesylate, triflate, acetate,
- metal complexes from the following Tables B to G may be employed.
- Table B shows platinum complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- DBA dibenzylideneacetone
- Table D shows nickel complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- DBA dibenzylideneacetone
- Table E shows copper complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- DBA dibenzylideneacetone
- Table F shows silver complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- DBA dibenzylideneacetone
- Table G shows gold complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- DBA dibenzylideneacetone
- the metal complexes may be palladium allyl complexes having the structure (V) or palladium aryl complexes having the structure (VI):
- Y, R 1 , R 2 may be defined as in the preceding items
- R 33 , R 34 and R 35 may be independently selected from H, alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups; or
- R 33 , R 34 and R 35 form a carbocyclic ring with 5 to 14 carbon atoms
- Ar represents a substituted or unsubstituted, especially a substituted, aryl group.
- R 33 , R 34 and R 35 may be independently selected from linear, branched-chain or cyclic C 1-10 alkyl groups, preferably from C 1-6 alkyl groups or C 4-10 -cycloalkyl groups
- the aryl groups are selected from C 6-14 aryl groups, preferably from C 6-10 aryl groups
- the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C 2-10 alkenyl groups, preferably from C 2-6 alkenyl groups
- the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and/or
- Ar are selected from C 6-14 aryl groups, preferably C 6-10 aryl groups, and the heteroaryl groups are selected from C 6-14 heteroaryl groups, preferably from C 6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and
- the functional groups are selected from alkyl (—R 11 ), especially C 1-6 alkyl groups, C 6-10 aryl (—R 12 ), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR 3 ), amino (—NR 11 2 , —NHR 11 , —NH 2 ), mercapto (—SH, —SR 11 ), wherein R 11 , independently of further R 11 residues, is selected from C 1-6 alkyl residues.
- X may be selected from the group of halogen, tosylate, nosylate and mesylate, especially X may be selected from the group of fluorine, chlorine, bromine, iodine, tosylate, nosylate and mesylate, and/or aryl may be selected from phenyl, m-tolyl, p-tolyl, o-tolyl, mesityl, 1,3-diisopropylphenyl.
- Palladium complexes containing at least one of the phosphane ligands described above, especially the palladium allyl complexes and palladium aryl complexes may be employed in homogeneous catalysis, especially in coupling reactions, wherein said coupling reaction may be selected from the group consisting of
- the metal of the metal complex as described above may be a precious metal and/or a transition metal, especially a metal of group 10 or 11 of the Periodic Table of the elements, where it has proven useful if the metal of the metal complex is selected from the group consisting of copper, silver, gold, platinum, palladium, nickel, and combinations thereof.
- the substrate may be a substituted aromatic compound, and in particular, the substituted aromatic compound may be an aromatic or heteroaromatic compound. It may be substituted, inter alia, with a leaving group, or an unsaturated aliphatic group, or a leaving group, where it has proven useful if said leaving group is selected from the group consisting of halogen, tosylate, nosylate and mesylate, and/or said unsaturated aliphatic group is selected from the group consisting of alkene or alkyne, especially with 2 to 12, especially with 2 to 8, carbon atoms.
- the coupling partner may comprise an organometallic compound, especially which may be selected from the group consisting of organic boron compounds, organolithium compounds, organozinc compounds, organolithium compounds, and Grignard compounds, wherein advantageously said organometallic compound includes at least one aromatic residue, or wherein said organometallic compound includes at least one unsaturated aliphatic residue, or wherein said organometallic compound includes at least one saturated aliphatic residue.
- organometallic compound especially which may be selected from the group consisting of organic boron compounds, organolithium compounds, organozinc compounds, organolithium compounds, and Grignard compounds, wherein advantageously said organometallic compound includes at least one aromatic residue, or wherein said organometallic compound includes at least one unsaturated aliphatic residue, or wherein said organometallic compound includes at least one saturated aliphatic residue.
- the corresponding onium salts are either commercially available, or can be prepared by standard synthesis methods, such as the quaternization of corresponding phosphane, sulfide or amine precursors with alkyl halides and tosylates.
- the salts (such as A in the following Scheme) can be deprotonated with metal bases, such as potassium tert-butanolate, metal hydrides or lithium/sodium/potassium bis(trimethylsilyl)amide, and directly react with the halophosphane to form the phosphanyl-substituted onium salt (e.g., B).
- metal bases such as potassium tert-butanolate, metal hydrides or lithium/sodium/potassium bis(trimethylsilyl)amide
- the latter can be converted to the desired ylide-functionalized phosphane with another equivalent of base without prior processing.
- Simple representatives can be obtained from the commercially available bis(diphenylphosphino)methane and bis(dicyclohexylphosphino)methane by quaternization with alkyl halides followed by deprotonation (J. Langer et al., ARKIVOC, 3, 210 (2012)).
- Other functionalizations can be realized according to the following Scheme. In particular, phosphanes, sulfides, amines, imines, N-heterocycles and sulfoxides have proven useful as the On moiety.
- the solid that had precipitated was filtered off and washed twice with 5 ml of toluene, and dried under vacuum.
- the solid and 670 mg of KHMDS (3.36 mmol) were dissolved in 20 ml of THF and stirred for 1 hour.
- the solid that had precipitated was removed by filtration, the solvent was removed under vacuum, and the residual solid was dissolved in 50 ml boiling hexane and filtered while still hot.
- the solution was slowly cooled down to RT and allowed to stand for 16 hours.
- the solution above the yellow crystals that had formed was removed, and the crystals were washed three times with 5 ml of cold hexane, followed by drying under vacuum (1.07 g, 1.98 mmol, 47%).
- the solvent of the red solution obtained was removed under vacuum, and the solid obtained was dried under vacuum. 20 ml of cyclohexane was added, the mixture was heated to boil, filtered while still hot, and then slowly cooled down to RT, wherein a red solid precipitated. The supernatant solution was removed, and the solid was washed twice with 2 ml of pentane and dried under vacuum (0.68 g, 0.98 mmol, 39%).
- the colorless solid was filtered off and washed twice with 20 ml each of THF, and stored under argon. The filtrate was dried under vacuum, and the resulting solid was dissolved in 100 ml of cyclohexane, filtered, and the cyclohexane was again removed under vacuum. After drying under vacuum, the product could be isolated as a colorless solid (4.93 g, 9.77 mmol, 85%).
- Phosphane Y* Me PCy 2 500 mg, 0.99 mmol, 1 eq.
- bis(dibenzylideneacetone)-palladium(0) 742 mg, 1.09 mmol
- the solution was filtered, and 1 ml of p-chlorotoluene was added, and the solution was stirred for 48 hours.
- the dark yellow precipitate was filtered off and washed three times with 10 ml of THF. After drying under vacuum, the product was obtained as a dark yellow solid (515 mg, 0.69 mmol, 70%).
- the complex proved to be unsoluble in all common solvents except DCM, in which it slowly decomposes, however.
- the phosphane gold chloride complexes prepared according to the protocol of Example 2B) were dissolved in a 1:1 mixture of alkyne and amine, and one equivalent of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate was added.
- the mixture was reacted under the conditions as stated in the Table below, in which the following conversion rates and yields were obtained.
- the catalysis did not show any decrease in yield under aqueous conditions, or upon exposure of the reaction mixture to air.
- OH additions to alkynes can also be effected.
- 4-pentynoic acid in THF reacts at room temperature with 0.5 mole % Y S PCy 2 .AuCl and an equimolar amount of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate completely to the desired lactone within 14 hours.
- aryl bromides can be employed in the coupling reactions.
- the C—C coupling reaction of boronic acid and haloaromatics was performed with the respective ylide-substituted phosphanes according to known synthesis protocols.
- the commercially available palladacycle di-p-chlorobis[2′-(amino-N)[1,1′-biphenyl]-2-yl-C]dipalladium(II) was used as a palladium precursor, and reacted with 1 equivalent of the phosphane ligand in THF.
- an aqueous solution of potassium phosphate the amine and the bromo- or chloroaromatic were made to react.
- a stock solution of catalyst and ligand was prepared by mixing 0.2 mmol palladium acetate Pd(OAc) 2 and 0.2 mmol YPhos in a Schlenk vessel. 1 ml of dry THF (tetrahydrofuran) was added, the mixture was stirred for 30 min, and 0.1 ml of the thus obtained solution was added to the reaction mixture, and all was stirred at 140° C. for 3 hours. Yields were determined by F-NMR analysis with ⁇ , ⁇ , ⁇ -trifluorotoluene as internal standard.
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Abstract
Description
- This application is a division of U.S. Ser. No. 16/636,962, filed Feb. 6, 2020, which is a national stage application (under 35 U.S.C. § 371) of PCT/EP2018/071550, filed Aug. 8, 2018, which claims benefit of German Application No. 102017213817.3, filed Aug. 8, 2017, all of which are incorporated herein by reference in their entirety.
- The invention relates to ylide-functionalized phosphane ligands, the preparation thereof, and the use thereof in transition metal compounds, and the use thereof as catalysts in organic reactions.
- The synthesis of complex molecules if often a central task in the fine chemicals industry, for example, in order to prepare products for the production of pharmaceuticals, dyes, agrochemicals, materials, etc. Catalytic processes for functionalization reactions are frequently required therein, such as coupling reactions (Suzuki, Heck, Sonogashira etc.) or hydrofunctionalizations (hydroamination, hydrosilylation, etc.) for the derivatization of olefins, aryls, or alkynes. Such catalyses are critically influenced by the metal and the ligands employed.
- Phosphanes are among the most frequently used ligands in catalysis. Adjusting their electronic and steric parameters is critical to increase the activity of a catalyst, to determine selectivities, and to be able to enlarge the substrate diversity (A. C. Hillier et al., Organometallics, 22: 4322 (2003); H. Clavier et al. Chem. Commun., 46: 841 (2010); Z. L. Niemeyer, A. Milo, D. P. Hickey, M. S. Sigman, Nature Chem. 8: 610 (2016); C. A. Tolman, Chem. Rev. 77, 313 (1977); G. Frenking, Organometallics, 28, 3901 (2009)). The variability of phosphanes and the possibility to manipulate their electronic and steric properties substantiates the preference of their use as compared to many other ligand systems. Therefore, phosphanes are employed in a wide variety of reactions, such as palladium-catalyzed coupling reactions (M. A. WOnsche et al., Angew. Chem. Int. Ed., 54, 11857 (2015); D. S. Surry et al., Angew. Chem. Int. Ed., 47, 6338 (2008); R. Martin et al., Acc. Chem. Res., 41, 1461 (2008); S. Kotha et al., Tetrahedron, 58, 9633 (2002)), or gold-catalyzed hydroamination reactions (Lavallo, V. et al.; Angew. Chem., Int. Ed., 52, 3172 (2013); E. Mizushima et al., Org. Lett., 5, 3349 (2003); Y. Wang et al., Nature. Commun., 1 (2014)). Novel active catalyst systems are based on, inter alia, adamantyl-functionalized phosphanes (DE-A-10037961, WO 02/10178, L. Chen et al., J. Am. Chem. Soc., 138, 6392 (2016); C. A. Fleckenstein et al., Chem. Soc. Rev., 39, 694 (2010); K. A. Agnew-Francis et al., Adv. Synth. Catal., 358, 675 (2016)), or biaryl phosphane ligands (U.S. Pat. No. 6,307,087, D. S. Surry et al., Angew. Chem., 120, 6438 (2008); Angew. Chem. Int. Ed., 47, 6338 (2008); R. A. Altman et al., Nat. Protoc., 2, 3115 (2007); D. S. Surry et al., Chem. Sci., 2, 27 (2011); E. J. Cho et al., Science, 328, 1679 (2010); D. A. Watson et al., Science, 325, 1661 (2009)). A survey of important homogeneous catalyses with phosphane ligands is found, for example, in B. Cornils, W. A. Hermann, Applied Homogenous Catalysis with Organometallic Compounds, Vol 12, VCH, Weinheim, 1996.
- Ligand design is decisive in catalysis to enable reactions, or to be able to direct them into desired directions. Thus, for example, the development of new phosphane ligands is often required to realize more cost-effective starting substrates (e.g., chlorides instead of iodides), higher catalyst productivities and activities, and a broader substrate and reaction diversity.
- Aspect (1): Phosphane ligands of formulas YPR1R2 (1), Y2PR1 (II) and Y3P (III)
- where
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- On, independently of the onium groups in other ylide substituents, is selected from phosphonium groups —P(R3R4R5), ammonium groups —N(R3R4R5), sulfoxonium groups —SOR3R4 and sulfonium groups —S(R3R4),
- X, independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR3R4R5), sulfonyl (—SO2R3), phosphoryl (—P(O)R3R4, —P(S)R3R4, —P(NR3)R4R5 2), cyano (—CN), alkoxy (—OR3) and amino (—NR3R4) groups, and
- R1, R2, R3, R4 and R5, if any, are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups, with the proviso that R1 and R2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R1 and R2 are not phenyl if X is p-toluylsulfonyl (—SO2(p-toluyl)) and Z is triphenylphosphonium.
- 2. The phosphane ligands according to item 1, wherein
- (i) the alkyl groups are selected from linear, branched-chain or cyclic C1-10 alkyl groups, preferably from C1-6 alkyl groups or C4-10-cycloalkyl groups, the aryl groups are selected from C6-14 aryl groups, preferably from C6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C2-10 alkenyl groups, preferably from C2-6 alkenyl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S; and/or
- (ii) the functional groups are selected from alkyl (—R11), especially C1-6 alkyl groups, C6-10 aryl (—R12), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR3), amino (—NR11 2, —NHR11, —NH2), mercapto (—SH, —SR11), wherein R11, independently of further R11 residues, is selected from C1-6 alkyl residues.
- 3. The phosphane ligands according to item 1 or 2, represented by formula (I) or (II)
- wherein On is a phosphonium group —P(R3R4R5), in which R3, R4 and R5 are independently selected from the group consisting of C1-6 alkyl groups, C4-10 cycloalkyl groups, C6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C1-6 alkyl groups, C6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C2-6 alkenyl groups, a trialkylsilyl (—SiR3R4R5), arylsulfonyl (R12—SO2R3) group, and R1 and R2 are C6-10 aryl groups or C1-6 alkyl and cycloalkyl groups.
- 4. The phosphane ligands according to one or more of the preceding items, wherein R3, R4 and R5 are independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof.
- 5. The phosphane ligands according to one or more of the preceding items, wherein R3, R4 and R5 are the same and are selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- 6. The phosphane ligands according to one or more of the preceding items, wherein X is selected from the group consisting of methyl, ethyl, cyclohexyl, phenyl, p-tolyl, trimethylsilyl, p-tolylsulfonyl, or combinations thereof.
- 7. The phosphane ligands according to one or more of the preceding items, wherein R1 and R2 are independently selected from the group consisting of phenyl, cyclohexyl, methyl, and combinations thereof.
- Aspect (2):
- 8. A process for preparing the phosphane ligands according to any of items 1 to 3, comprising
- (a) the reaction of a metallated ylide with a halophosphane, a dihalophosphane, or phosphorus trichloride,
- (b) the reaction of an ylide-functionalized halophosphane or dihalophosphane with an organometallicreagent,
- (c) the phosphanylation of an onium salt, phosphanylation with halophosphanes in the presence of a base, or
- (d) the deprotonation of an a-phosphanyl substituted onium salt with a base.
- Aspect (3):
- 9. Use of the phosphane ligands according to any of items 1 to 3 in the synthesis of metal complexes or metal salts.
- 10. The use according to item 9, wherein said metal complexes or metal salts are precious metal or transition metal complexes or precious metal or transition metal compounds.
- 11. The use according to item 9 or 10, wherein said metal, precious metal or transition metal complexes and salts with the phosphane ligands according to any of items 1 to 7 are employed in homogeneous catalysis.
- Aspect (4):
- 12. Use of the phosphane ligands according to any of items 1 to 7 in combination with metal, precious metal or transition metal complexes or metal, precious metal or transition metal salts as catalysts, wherein the ligands are added to the metal, precious metal or transition metal precursor compounds in situ, or the isolated metal, precious metal or transition metal complexes of the phosphane ligands according to aspect (3) are employed.
- 13. The use according to items 9 to 12, wherein the metals platinum, palladium and nickel, preferably palladium, are used.
- 14. The use according to items 9 to 13, wherein the metals copper, silver and gold, preferably gold, are used.
- 15. The use according to items 9 to 14, wherein the ligands are employed
- (i) in catalytic hydrofunctionalization reactions of alkynes and alkenes;
- (ii) in catalytic hydroamination reactions of alkynes and alkenes;
- (iii) in catalytic O—H addition reactions to alkynes and alkenes;
- (iv) in catalytic coupling reactions;
- (v) in catalytic Suzuki coupling reactions, especially for the preparation of biaryls;
- (vi) in catalytic cross-coupling reactions, especially C—N and C—O coupling reactions; and/or
- (vii) in catalytic Heck coupling reactions, especially for the preparation of arylated olefins, and Sonogashira coupling reactions, especially for the preparation of arylated and alkenylated alkynes.
- Aspect (5):
- 16. Metal complexes containing a phosphane ligand of formulas YPR1R2 (I), Y2PR1 (II) and Y3P (III)
- where
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- On, independently of the onium groups in other ylide substituents, is selected from phosphonium groups —P(R3R4R5), ammonium groups —N(R3R4R5), sulfonium groups —SOR3R4 and sulfonium groups —S(R3R4),
- X, independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR3 3R4R5), sulfonyl (—SO2R3), phosphoryl (—P(O)R3R4, —P(S)R3R4, —P(NR3)R4R5 2), cyano (—CN), alkoxy (—OR) and amino (—NR2) groups, and
- R1, R2, R3, R4 and R5, if any, are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups, with the proviso that R1 and R2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R1 and R2 are not phenyl if X is p-toluylsulfonyl (—SO2(p-toluyl)) and Z is triphenylphosphonium.
- 17. The metal complexes according to item 16, wherein (i) the alkyl groups are selected from linear, branched-chain or cyclic C1-10 alkyl groups, preferably from C1-6 alkyl groups or C4-10-cycloalkyl groups, the aryl groups are selected from C6-14 aryl groups, preferably from C6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C2-10 alkenyl groups, preferably from C2-6 alkenyl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S; and/or (ii) the functional groups are selected from alkyl (—R11), especially C1-6 alkyl groups, C6-10 aryl (—R12), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR3), amino (—NR11 2, —NHR11, —NH2), mercapto (—SH, —SR11), wherein R11, independently of further R11 residues, is selected from C1-6 alkyl residues.
- 18. The metal complexes according to item 16 or 17, having phosphane ligands of formula (I) or (II)
- wherein On is a phosphonium group —P(R3R4R5), in which R3, R4 and R5 are independently selected from the group consisting of C1-6 alkyl groups, C4-10 cycloalkyl groups, C6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C1-6 alkyl groups, C6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C2-6 alkenyl groups, a trialkylsilyl (—SiR3R4R5), arylsulfonyl (R12—SO2R3) group, and R1 and R2 are C6-10 aryl groups or C1-6 alkyl and cycloalkyl groups.
- 19. The metal complexes according to one or more of the above items, wherein R3, R4 and R5 are independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof.
- 20. The metal complexes according to one or more of the preceding items, wherein R3, R4 and R5 are the same and are selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- 21. The metal complexes according to one or more of the preceding items, wherein X is selected from the group consisting of methyl, ethyl, cyclohexyl, phenyl, p-tolyl, trimethylsilyl, p-tolylsulfonyl, or combinations thereof.
- 22. The metal complexes according to one or more of the preceding items, wherein R1 and R2 are independently selected from the group consisting of phenyl, cyclohexyl, methyl, tert-butyl and combinations thereof.
- 23. The metal complexes according to items 18 to 22, wherein said complex is a palladium allyl complex having the following structure (V) or (VI):
- wherein X is an anion,
- Y, R1, R2 are defined as in the preceding items,
- R33, R34 and R35 are independently selected from H, alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups; or
- at least two of R33, R34 and R35 form a carbocyclic ring with 5 to 14 carbon atoms,
- Ar represents a substituted or unsubstituted, especially a substituted, aryl group.
- 24. The metal complexes according to item 23, wherein R33, R34 and R35 are independently selected from linear, branched-chain or cyclic C1-10 alkyl groups, preferably from C1-6 alkyl groups or C4-10-cycloalkyl groups, the aryl groups are selected from C6-14 aryl groups, preferably from C6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C2-10 alkenyl groups, preferably from C2-6 alkenyl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and/or
- at least two of R33, R34 and R35 form a carbocyclic ring that is a C4-10 cycloalkyl group, or a C6-14 aryl group, which may be substituted with one or more functional groups; and
- Ar are selected from C6-14 aryl groups, preferably C6-10 aryl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and
- the functional groups are selected from alkyl (—R11), especially C1-6 alkyl groups, C6-10 aryl (—R12), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR3), amino (—NR11 2, —NHR11, —NH2), mercapto (—SH, —SR11), wherein R11, independently of further R11 residues, is selected from C1-6 alkyl residues.
- 25. The metal complexes according to item 23 or 24, wherein X is selected from the group of halogen, tosylate, nosylate and mesylate.
- 26. The metal complexes according to one or more of the preceding items, wherein X is selected from the group of fluorine, chlorine, bromine, iodine, tosylate, nosylate and mesylate, and/or aryl is selected from phenyl, m-tolyl, p-tolyl, o-tolyl, mesityl, 1,3-diisopropylphenyl.
- 27. A process for performing a coupling reaction containing the steps of
-
- providing a reaction mixture containing at least a substrate, coupling partner, and a metal complex according to item 16 to 26, or a metal complex containing a ligand according to item 1; and
- reacting said substrate with said coupling partner in the presence of the metal complex or its derivative to form a coupling product.
- 28. The process according to item 27, wherein the metal of said metal complex is a precious metal and/or a transition metal.
- 29. The process according to item 27 or 28, wherein the metal of said metal complex is a metal of group 10 or 11 of the Periodic Table of the elements.
- 30. The process according to one or more of items 27 to 29, wherein the metal of said metal complex is selected from the group consisting of copper, silver, gold, platinum, palladium, nickel, and combinations thereof.
- 31. The process according to one or more of items 27 to 30, wherein the substrate is a substituted aromatic compound.
- 32. The process according to item 31, wherein said substituted aromatic compound is an aromatic or heteroaromatic compound.
- 33. The process according to item 31 or 32, wherein said substituted aromatic compound is substituted with a leaving group, or an unsaturated aliphatic group, or leaving group.
- 34. The process according to item 33, wherein said leaving group is selected from the group consisting of halogen, tosylate, nosylate and mesylate, and/or said unsaturated aliphatic group is selected from the group consisting of alkene or alkyne, especially with 2 to 12, especially with 2 to 8, carbon atoms.
- 35. The process according to one or more of the preceding items, wherein the coupling partner comprises an organometallic compound.
- 36. The process according to item 35, wherein said organometallic compound is selected from the group consisting of organic boron compounds, organolithium compounds, organozinc compounds, organolithium compounds, and Grignard compounds.
- 37. The process according to item 35 or 36, wherein said organometallic compound includes at least one aromatic residue.
- 38. The process according to item 36, wherein said organometallic compound includes at least one unsaturated aliphatic residue.
- 39. The process according to item 36, wherein said organometallic compound includes at least one saturated aliphatic residue.
- 40. The process according to one or more of items 27 to 39, wherein the coupling reaction may be selected from the group consisting o
- (i) catalytic hydrofunctionalization reactions of alkynes and alkenes;
- (ii) catalytic hydroamination reactions of alkynes and alkenes;
- (iii) catalytic O—H addition reactions to alkynes and alkenes;
- (iv) catalytic coupling reactions;
- (v) catalytic Suzuki coupling reactions, especially for the preparation of biaryls;
- (vi) catalytic cross-coupling reactions, especially C—N and C—O coupling reactions; and/or
- (vii) catalytic Heck coupling reactions, especially for the preparation of arylated olefins, and
- Sonogashira coupling reactions, especially for the preparation of arylated and alkenylated alkynes.
- 41. Use of the metal complexes according to items 16 to 26 in homogeneous catalysis, advantageously in coupling reactions, which may be selected from the group consisting of
- (i) catalytic hydrofunctionalization reactions of alkynes and alkenes;
- (ii) catalytic hydroamination reactions of alkynes and alkenes;
- (iii) catalytic O—H addition reactions to alkynes and alkenes;
- (iv) catalytic coupling reactions;
- (v) catalytic Suzuki coupling reactions, especially for the preparation of biaryls;
- (vi) catalytic cross-coupling reactions, especially C—N and C—O coupling reactions; and/or
- (vii) catalytic Heck coupling reactions, especially for the preparation of arylated olefins, and
- Sonogashira coupling reactions, especially for the preparation of arylated and alkenylated alkynes.
- It has now been found that the ylide-functionalized phosphane ligands of formulas (I), (II) and (III) having a carbanionic carbon center in a-position to the phosphorus atom as described below and their transition metal complexes achieve the above object. Thus, the invention relates to:
- (1) phosphane ligands of formulas YPRR′ (I), Y2PR (II) and Y3P (III)
- where
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- On, independently of the onium groups in other ylide substituents, is selected from phosphonium groups —PRR′2, ammonium groups —NRR′2, sulfoxonium groups —SOR2 and sulfonium groups —SRR′,
- X, independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR3), sulfonyl (—SO2R), phosphoryl (—P(O)R2, —P(S)R2, —P(NR)R2), cyano (—CN), alkoxy (—OR) and amino groups (—NR2), and
- R and R′, if any, are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups;
- (2) a process for preparing the phosphane ligands according to aspect (1), comprising
- (a) the reaction of a metallated ylide with a halophosphane, a dihalophosphane, or phosphorus trichloride,
- (b) the reaction of an ylide-functionalized halophosphane or dihalophosphane with an organometallicreagent,
- (c) the phosphanylation of an onium salt, phosphanylation with halophosphanes in the presence of a base, or
- (d) the deprotonation of an a-phosphanyl substituted onium salt with a base;
- (3) the use of the phosphane ligands according to aspect (1) in the synthesis of transition metal complexes or transition metal salts; and
- (4) the use of the phosphane ligands according to aspect (1) in combination with transition metal complexes or transition metal salts as catalysts, wherein the ligands are added to the transition metal precursor compounds in situ, or the isolated transition metal complexes of the phosphane ligands obtainable according to aspect (3) are employed.
- Aspect (1) of the invention provides phosphane ligands of formulas YPRR′ (I), Y2PR (II) and Y3P (III).
- In the formula, R and R′ represent alkyl, aryl and heteroaromatic residues with and without further functional groups (e.g., amines, ethers).
- “On” describes a substituent with a positive charge, such as onium groups, mainly phosphonium groups —PRR′2, ammonium —NRR′2, sulfoxonium groups —SOR2, or sulfonium groups —SRR′. The carbon atom directly bound to the phosphorus atom formally bears a negative charge.
- X symbolizes alkyl, aryl or alkenyl groups both with and without further functional groups, heteroaromatics, as well as hydrogen or functional groups, such as silyl, sulfonyl (—SO2R with R=alkyl, aryl), phosphoryl (—P(O)R2, —P(S)R2, —P(NR)R2), —CN, alkoxy (—OR), amino (—NR2), wherein the residue R always includes alkyl and aryl residues.
- Preferably, the alkyl groups are selected from linear, branched-chain or cyclic C1-10 alkyl groups, preferably from C1-6 alkyl groups, the aryl groups are selected from C6-14 aryl groups, preferably from C6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C2-10 alkenyl groups, preferably from C2-6 alkenyl groups, and the heteroaryl groups are selected from C4-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from B, N, O and S. It is further preferred that the functional groups are selected from alkyl (—R″), perfluoroalkyl (—CxF2x+1, with x=1 to 6, such as —CF3, —C2F5 etc.), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR″), carbonyl (—CO2H, —CO2R″, —COR″, —CONHR″), amino (—NR″2, —NHR″, —NH2), amido (—NHCOR″, —NHSO2R″), mercapto (—SH, —SR″), sulfonyl (—SO3H, —SO2R″), phosphorus (—PR″3, —P(O)R″2, —P(S)R″2, —P(NR)R″2), silyl (—SiR″3) and nitro groups, wherein R″, independently of further R″ residues, is selected from C1-6 alkyl and C6-14 aryl residues.
- In addition to the simple ylide substitution, the phosphanes may also be doubly and triply ylide-substituted to obtain phosphanes of formulas (II) Y2PR and (III) Y3P. A preferred embodiment of aspect (1) are phosphane ligands of formula (I)
- where On is a triarylphosphonium group, especially a triphenylphosphonium group, X is a trialkylsilyl, cyano (—CN), methyl or arylsulfonyl group, especially a trimethylsilyl or p-tolylsulfonyl group, and R and R′ are aryl or alkyl groups, especially phenyl, cyclohexyl or methyl groups.
- Aspect (2) of this invention relates to the preparation of the ylide-functionalized phosphane ligands according to the invention. They can be prepared via two alternative synthetic pathways, which allows for a broad variation of the substitution pattern: The synthesis can be achieved either through an a-metallated ylide, which is reacted with a corresponding chlorophosphane (route A), or through the a-deprotonation of an a-phosphanyl-substituted phosphonium salt (route B).
- Route A: The a-metallated ylides required for route A can be prepared by the deprotonation of classical ylides with metal bases, such as organolithium compounds or alkali metal amides (T. Scherpf et al., Angew. Chem. Int. Ed., 54, 8542 (2015); Bestmann, H. J. et al.; Angew. Chem. Int. Ed., 26, 79 (1987)). The reaction thereof with chlorophosphanes of the type RR′PCI (R, R′=alkyl, aryl residues) yields the ylide-functionalized phosphane on a direct route. When phosphorus trichloride is used, ylide-functionalized chlorophosphanes of the type YPCl2 can also be prepared, which can be reacted in a further step with organometallic reagents (or organolithium, organomagnesium and organozinc reagents) to form an alkyl/aryl phosphane. Reactions of chlorophosphanes with metal bases are described, for example, in Houben-Weyl, Methoden der organischen Chemie, 1963, volume XII, 1 S33. The use of phosphorus trichloride and dichlorophosphanes also enables access to multiply ylide-substituted phosphanes.
- Route B: Preparation method B is a practical alternative to route A, which circumvents the isolation of sensitive metallated intermediates. Proceeding from a classical onium salts, the introduction of the phosphane moiety is effected by using a halophosphane in the presence of a base. When an excess of base is used, the formation of the ylide-functionalized phosphane is achieved on a direct route. Thus, this method allows for the preparation of the ligands from readily available starting substances or from commercially available precursors.
- The novel phosphanes are reacted with transition metal compounds to form the corresponding complexes, such as with compounds of the metals Ni, Pd, Pt, Rh, Ir, Cu and Au. The complexes can be either isolated as solids, or generated in situ and used further for catalytic applications. In the complexes, the phosphane ligands prove to be very strong donor ligands whose donor capabilities exceeds that of classical phosphane ligands. This could be demonstrated by means of the Tolman parameter (TEP), i.e., by means of infrared spectroscopy and determination of the CO stretching vibration in the corresponding Rh(acac)(CO)L complexes (with L=phosphane ligand, and acac=acetylacetonato) (C. A. Tolman, Chem. Rev. 77, 313 (1977)).
- The transition metal complexes of the ylide-functionalized phosphane ligands are employed in different homogeneously catalyzed reactions, such as in palladium-catalyzed coupling reactions (e.g., C—C—, C—O, C—N couplings), and gold-catalyzed hydroamination reactions. In these reactions, they exhibit extraordinarily high activities that exceed those of analogous complexes with common phosphane ligands. Thus, in the gold-catalyzed hydroamination of alkynes, high conversion rates are observed already at room temperature. In part, TONs of more than 10,000 are achieved. Analogous reactions with other phosphane ligands usually require higher reaction temperatures of further additions of additives (D. Malhotra et al., Angew. Chem. Int. Ed., 53, 4456 (2014); E. Mizushima et al., Org. Lett., 5, 3349 (2003)). In addition, the systems in part proved to be extremely robust towards water and atmospheric oxygen, so that catalyses could be performed also without taking further precautionary protective measures. This applies, for example, to the autocatalyzed hydroamination of phenylacetylene, which did not show any decrease in catalytic activity even in the presence of water. In the case of the palladium-catalyzed coupling and cross-coupling reactions, comparably mild reaction conditions could be applied, and even couplings of aryl chlorides could be realized. For example, in the case of C—N coupling reactions, high conversion rates even with difficult substrates could be achieved already at room temperature.
- Therefore, the invention relates to phosphane ligands of formulas YPRR2 (I), Y2PR1 (II) and Y3P (III)
- where
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- On, independently of the onium groups in other ylide substituents, is selected from phosphonium groups —P(R3R4R5), ammonium groups —N(R3R4R5), sulfoxonium groups —SOR3R4 and sulfonium groups —S(R3R4),
- X, independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR3R4R5), sulfonyl (—SO2R3), phosphoryl (—P(O)R3R4, —P(S)R3R4, —P(NR3)R4R5 2), cyano (—CN), alkoxy (—OR3) and amino (—NR3R4) groups, and
- R1, R2, R3, R4 and R5, if any, are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups;
- especially with the proviso that R1 and R2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R1 and R2 are not phenyl if X is p-toluylsulfonyl (—SO2(p-toluyl)) and Z is triphenylphosphonium.
- In these ligands:
- (i) the alkyl groups are selected from linear, branched-chain or cyclic C1-10 alkyl groups, preferably from C1-6 alkyl groups, the aryl groups are selected from C6-14 aryl groups, preferably from C6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C2-10 alkenyl groups, preferably from C2-6 alkenyl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from B, N, O and S, and/or
- (ii) the functional groups are selected from alkyl (—R11), perfluoroalkyl (—CxF2x+1, with x=1 to 6, such as —CF3, —C2F5 etc.), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR″), carbonyl (—CO2H, —CO2R″, —COR″, —CONHR″), amino (—NR″2, —NHR″, —NH2), amido (—NHCOR″, —NHSO2R″), mercapto (—SH, —SR″), sulfonyl (—SO3H, —SO2R″), phosphorus (—PR″3, —P(O)R″2, —P(S)R″2, —P(NR)R″2), silyl (—SiR″3) and nitro groups, wherein R″, independently of further R″ residues, is selected from C1-6 alkyl and C6-14 aryl residues.
- A specific embodiment relates to phosphane ligands represented by formula (I) or (II)
- wherein On is a phosphonium group —P(R3R4R5), in which R3, R4 and R5 are independently selected from the group consisting of C1-6 alkyl groups, C4-10 cycloalkyl groups, C6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C1-6 alkyl groups, C6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C2-6 alkenyl groups, a trialkylsilyl (—SiR3R4R5), arylsulfonyl (R12—SO2R3) group, and R1 and R2 are C6-10 aryl groups or C1-6 alkyl and cycloalkyl groups.
- R3, R4 and R5 may be independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof. R3, R4 and R5 may be the same and selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- X may be selected from the group consisting of methyl, ethyl, cyclohexyl, phenyl, p-tolyl, trimethylsilyl, p-tolylsulfonyl, or combinations thereof.
- R1 and R2 may be independently selected from the group consisting of phenyl, cyclohexyl, methyl, and combinations thereof.
- Another embodiment relates to a process for preparing the phosphane ligands, comprising
- (a) the reaction of a metallated ylide with a halophosphane, a dihalophosphane, or phosphorus trichloride,
- (b) the reaction of an ylide-functionalized halophosphane or dihalophosphane with an organometallic reagent,
- (c) the phosphanylation of an onium salt with halophosphanes in the presence of a base, or
- (d) the deprotonation of an a-phosphanyl substituted onium salt with a base.
- The phosphane ligands may be used in the synthesis of metal complexes or metal salts.
- In particular, these may be precious metal or transition metal complexes or precious metal or transition metal compounds. In particular, metals of group 10 or 11 of the Periodic Table of the elements may be employed.
- The metal, precious metal or transition metal complexes and salts with the phosphane ligands as described above may be employed in homogeneous catalysis.
- In particular, the phosphane ligands according to aspect (3) may be employed in combination with metal, precious metal or transition metal complexes or metal, precious metal or transition metal salts as catalysts, wherein the ligands are added to the metal, precious metal or transition metal precursor compounds in situ, or the isolated metal, precious metal or transition metal complexes of the phosphane ligands according to aspect (3) may be employed in the synthesis of transition metal complexes or transition metal salts.
- In one embodiment, the metals platinum, palladium and nickel, preferably palladium, may be used In another embodiment, the metals copper, silver and gold, preferably gold, may be used.
- In the above uses, the ligands may be employed
- (i) in catalytic hydrofunctionalization reactions of alkynes and alkenes;
- (ii) in catalytic hydroamination reactions of alkynes and alkenes;
- (iii) in catalytic O—H addition reactions to alkynes and alkenes;
- (iv) in catalytic coupling reactions;
- (v) in catalytic Suzuki coupling reactions, especially for the preparation of biaryls;
- (vi) in catalytic cross-coupling reactions, especially C—N and C—O coupling reactions; and/or
- (vii) in catalytic Heck coupling reactions, especially for the preparation of arylated olefins, and Sonogashira coupling reactions, especially for the preparation of arylated and alkenylated alkynes.
- In particular, the patent application further relates to metal complexes containing a phosphane ligand of formulas YPR1R2 (I), Y2PR1 (II) and Y3P (III)
- where
- Y represents an ylide substituent bound to the phosphorus atom through the carbanionic center and having onium groups On and X groups,
- On, independently of the onium groups in other ylide substituents, is selected from phosphonium groups —P(R3R4R5), ammonium groups —N(R3R4R5), sulfoxonium groups —SOR3R4 and sulfonium groups —S(R3R4),
- X, independently of the X groups in other ylide substituents, is selected from hydrogen, alkyl, aryl, alkenyl and heteroaryl groups that may be unsubstituted or substituted with functional groups, silyl (—SiR3 3R4R5), sulfonyl (—SO2R3), phosphoryl (—P(O)R3R4, —P(S)R3R4, —P(NR3)R4R5 2), cyano (—CN), alkoxy (—OR3) and amino (—NR3R4) groups, and
- R1, R2, R3, R4 and R5, if any, are independently selected from alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups, with the proviso that R1 and R2 are not methyl if X is hydrogen or trimethylsilyl and Z is trimethylphosphonium, or that R1 and R2 are not phenyl if X is p-toluylsulfonyl (—SO2(p-toluyl)) and Z is triphenylphosphonium.
- The alkyl groups may be selected from linear, branched-chain or cyclic C1-10 alkyl groups, preferably from C1-6 alkyl groups or C4-10-cycloalkyl groups, the aryl groups are selected from C6-14 aryl groups, preferably from C6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C2-10 alkenyl groups, preferably from C2-6 alkenyl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S; and/or
- (ii) the functional groups are selected from alkyl (—R11), especially C1-6 alkyl groups, C6-10 aryl (—R12), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR3), amino (—NR11 2, —NHR11, —NH2), mercapto (—SH, —SR11), wherein R11, independently of further R11 residues, is selected from C1-6 alkyl residues.
- The metal complexes may be, in particular, precious metal or transition metal complexes or precious metal or transition metal compounds. In particular, metals of group 10 or 11 of the Periodic Table of Elements may be employed.
- In one embodiment, the metals platinum, palladium and nickel, preferably palladium, may be used.
- In another embodiment, the metals copper, silver and gold, preferably gold, may be used. Advantageously, these may be metal complexes having phosphane ligands of formula (I) or (II)
- wherein On is a phosphonium group —P(R3R4R5), in which R3, R4 and R5 are independently selected from the group consisting of C1-6 alkyl groups, C4-10 cycloalkyl groups, C6-10 aryl groups, X is selected from the group consisting of linear, branched-chain or cyclic C1-6 alkyl groups, C6-10 aryl groups, mono- or polyunsaturated linear, branched-chain or cyclic C2-6 alkenyl groups, a trialkylsilyl (—SiR3R4R5), arylsulfonyl (R12—SO2R3) group, and R1 and R2 are C6-10 aryl groups or C1-6 alkyl and cycloalkyl groups.
- In particular, R3, R4 and R5 may be independently selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, or R3, R4 and R5 may be the same and be selected from the group consisting of methyl, ethyl, butyl, cyclohexyl, phenyl, and combinations thereof, especially cyclohexyl and phenyl.
- In the metal complexes, X may be selected from the group consisting of methyl, ethyl, cyclohexyl, phenyl, p-tolyl, trimethylsilyl, p-tolylsulfonyl, or combinations thereof.
- Also, R1 and R2 may be independently selected from the group consisting of phenyl, cyclohexyl, methyl, tert-butyl, and combinations thereof.
- Advantageous ligands may be, in particular, ligands of the above formulas (I) or (II) with the substituents according to the following Table 1:
-
No. R1, R2 On X 1 tert-butyl PPh3 phenyl 2 phenyl PPh3 phenyl 3 methyl PPh3 phenyl 4 cyclohexyl PPh3 phenyl 5 tert-butyl PCy3 phenyl 6 phenyl PCy3 phenyl 7 methyl PCy3 phenyl 8 cyclohexyl PCy3 phenyl 9 tert-butyl PPh3 methyl 10 phenyl PPh3 methyl 11 methyl PPh3 methyl 12 cyclohexyl PPh3 methyl 13 tert-butyl PCy3 methyl 14 phenyl PCy3 methyl 15 methyl PCy3 methyl 16 cyclohexyl PCy3 methyl 17 tert-butyl PPh3 trimethylsilyl 18 phenyl PPh3 trimethylsilyl 19 methyl PPh3 trimethylsilyl 20 cyclohexyl PPh3 trimethylsilyl 21 tert-butyl PCy3 trimethylsilyl 22 phenyl PCy3 trimethylsilyl 23 methyl PCy3 trimethylsilyl 24 cyclohexyl PCy3 trimethylsilyl 25 tert-butyl PPh3 tolylsulfonyl SO2Tol 26 phenyl PPh3 tolylsulfonyl SO2Tol 27 methyl PPh3 tolylsulfonyl SO2Tol 28 cyclohexyl PPh3 tolylsulfonyl SO2Tol 29 tert-butyl PCy3 tolylsulfonyl SO2Tol 30 phenyl PCy3 tolylsulfonyl SO2Tol 31 methyl PCy3 tolylsulfonyl SO2Tol 32 cyclohexyl PCy3 tolylsulfonyl SO2Tol - wherein PPh3 represents triphenylphosphine, and PCy3 represents tricyclohexylphosphine. The metal complexes may be, in particular, precious metal or transition metal complexes or precious metal or transition metal compounds. In particular, metals of group 10 or 11 of the Periodic Table of Elements may be employed.
- In one embodiment, the metals platinum, palladium and nickel, preferably palladium, may be used.
- In another embodiment, the metals copper, silver and gold, preferably gold, may be used.
- The metal complexes may also have further ligands, such as neutral electron donor ligands, for example, dibenzylideneacetone (DBA), carbon monoxide CO, NHC ligands, phosphines, such as triphenylphosphine or tricyclohexylphosphine, and amines, such as triethylamine or tributylamine. Also, charged ligands, such as halogens, especially chloride, bromide and iodide, or the pseudohalides mesylate, triflate, acetate, may be present. Substituted or unsubstituted aryl and allyl ligands may also be present, as can mono- or diolefins, which may be linear or cyclic, such as cyclooctadiene.
- Thus, advantageously, the metal complexes may additionally include, in particular, ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- In particular, metal complexes from the following Tables B to G may be employed.
- Table B
- Table B shows platinum complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- Table C
- Table C shows palladium complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- Table D
- Table D shows nickel complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- Table E
- Table E shows copper complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- Table F
- Table F shows silver complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- Table G
- Table G shows gold complexes with at least one of the 32 phosphane ligands set forth in Table A, and one or more of the ligands selected from the group consisting of dibenzylideneacetone (DBA), carbon monoxide CO, triphenylphosphine, tricyclohexylphosphine, triethylamine, tributylamine, pyridyl, chloride, bromide, iodide, mesylate, triflate, acetate, allyl, phenyl, p-tolyl, o-tolyl, mesityl, cyclooctadiene, and combinations thereof.
- The metal complexes can be obtained in a per se known manner, such as by reacting metal salts or metal complexes, which advantageously already bear desirable further ligands (such as nickel tetracarbonyl, (THT)AuCl (THT=tetrahydrothiophene), allylpalladium(II) chloride dimer, palladium acetate, palladium chloride, or tris(dibenzylideneacetone)dipalladium(0) x dibenzylideneacetone), with one or more phosphane ligands, optionally in a suitable solvent.
- The metal complexes described above may be employed in homogeneous catalysis, especially in coupling reactions, wherein said coupling reaction may be selected from the group consisting of
- (i) catalytic hydrofunctionalization reactions of alkynes and alkenes;
- (ii) catalytic hydroamination reactions of alkynes and alkenes;
- (iii) catalytic O—H addition reactions to alkynes and alkenes;
- (iv) catalytic coupling reactions;
- (v) catalytic Suzuki coupling reactions, especially for the preparation of biaryls;
- (vi) catalytic cross-coupling reactions, especially C—N and C—O coupling reactions; and/or
- (vii) catalytic Heck coupling reactions, especially for the preparation of arylated olefins, and Sonogashira coupling reactions, especially for the preparation of arylated and alkenylated alkynes.
- In addition, the metal complexes may be palladium allyl complexes having the structure (V) or palladium aryl complexes having the structure (VI):
- wherein X is an anion,
- Y, R1, R2 may be defined as in the preceding items,
- R33, R34 and R35 may be independently selected from H, alkyl, aryl and heteroaryl groups that may be unsubstituted or substituted with functional groups; or
- at least two of R33, R34 and R35 form a carbocyclic ring with 5 to 14 carbon atoms,
- Ar represents a substituted or unsubstituted, especially a substituted, aryl group.
- Thus, R33, R34 and R35 may be independently selected from linear, branched-chain or cyclic C1-10 alkyl groups, preferably from C1-6 alkyl groups or C4-10-cycloalkyl groups, the aryl groups are selected from C6-14 aryl groups, preferably from C6-10 aryl groups, the alkenyl groups are selected from mono- or polyunsaturated linear, branched-chain or cyclic C2-10 alkenyl groups, preferably from C2-6 alkenyl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and/or
- at least two of R33, R34 and R35 form a carbocyclic ring that is a C4-10 cycloalkyl group, or a C6-14 aryl group, which may be substituted with one or more functional groups; and
- Ar are selected from C6-14 aryl groups, preferably C6-10 aryl groups, and the heteroaryl groups are selected from C6-14 heteroaryl groups, preferably from C6-10 heteroaryl groups having 1 to 5 heteroatoms selected from N, O and S, wherein all of the groups mentioned above may be substituted with functional groups; and
- the functional groups are selected from alkyl (—R11), especially C1-6 alkyl groups, C6-10 aryl (—R12), halogen (—Hal), hydroxy (—OH), cyano (—CN), alkoxy (—OR3), amino (—NR11 2, —NHR11, —NH2), mercapto (—SH, —SR11), wherein R11, independently of further R11 residues, is selected from C1-6 alkyl residues.
- In particular, X may be selected from the group of halogen, tosylate, nosylate and mesylate, especially X may be selected from the group of fluorine, chlorine, bromine, iodine, tosylate, nosylate and mesylate, and/or aryl may be selected from phenyl, m-tolyl, p-tolyl, o-tolyl, mesityl, 1,3-diisopropylphenyl.
- Palladium complexes containing at least one of the phosphane ligands described above, especially the palladium allyl complexes and palladium aryl complexes may be employed in homogeneous catalysis, especially in coupling reactions, wherein said coupling reaction may be selected from the group consisting of
- (i) catalytic hydrofunctionalization reactions of alkynes and alkenes;
- (ii) catalytic hydroamination reactions of alkynes and alkenes;
- (iii) catalytic O—H addition reactions to alkynes and alkenes;
- (iv) catalytic coupling reactions;
- (v) catalytic Suzuki coupling reactions, especially for the preparation of biaryls;
- (vi) catalytic cross-coupling reactions, especially C—N and C—O coupling reactions; and/or
- (vii) catalytic Heck coupling reactions, especially for the preparation of arylated olefins, and Sonogashira coupling reactions, especially for the preparation of arylated and alkenylated alkynes.
- In addition, the patent application relates to a process for performing a coupling reaction containing the steps of
-
- providing a reaction mixture containing at least a substrate, coupling partner, and at least one of the above metal complexes, or a metal complex containing one of the above described ligands; and
- reacting said substrate with said coupling partner in the presence of the metal complex or its derivative to form a coupling product.
- Here too, the metal of the metal complex as described above may be a precious metal and/or a transition metal, especially a metal of group 10 or 11 of the Periodic Table of the elements, where it has proven useful if the metal of the metal complex is selected from the group consisting of copper, silver, gold, platinum, palladium, nickel, and combinations thereof.
- The substrate may be a substituted aromatic compound, and in particular, the substituted aromatic compound may be an aromatic or heteroaromatic compound. It may be substituted, inter alia, with a leaving group, or an unsaturated aliphatic group, or a leaving group, where it has proven useful if said leaving group is selected from the group consisting of halogen, tosylate, nosylate and mesylate, and/or said unsaturated aliphatic group is selected from the group consisting of alkene or alkyne, especially with 2 to 12, especially with 2 to 8, carbon atoms.
- The coupling partner may comprise an organometallic compound, especially which may be selected from the group consisting of organic boron compounds, organolithium compounds, organozinc compounds, organolithium compounds, and Grignard compounds, wherein advantageously said organometallic compound includes at least one aromatic residue, or wherein said organometallic compound includes at least one unsaturated aliphatic residue, or wherein said organometallic compound includes at least one saturated aliphatic residue.
- Also, the patent application relates to such a process wherein the coupling reaction is selected from the group consisting of
- (i) catalytic hydrofunctionalization reactions of alkynes and alkenes;
- (ii) catalytic hydroamination reactions of alkynes and alkenes;
- (iii) catalytic O—H addition reactions to alkynes and alkenes;
- (iv) catalytic coupling reactions;
- (v) catalytic Suzuki coupling reactions, especially for the preparation of biaryls;
- (vi) catalytic cross-coupling reactions, especially C—N and C—O coupling reactions; and/or
- (vii) catalytic Heck coupling reactions, especially for the preparation of arylated olefins, and Sonogashira coupling reactions, especially for the preparation of arylated and alkenylated alkynes.
- The invention is further explained by means of the following Examples. They are exemplary for the preparation of the ylide-functionalized phosphanes, their transition metal complexes, and the use thereof in catalysis, and they are by no means to be understood as limiting the scope of protection of the invention.
- A) Preparation Through Metallated Ylides with Monochlorophosphanes (Route A)
- Preparation of the ylide-functionalized bis(cyclohexyl)phosphane with On=PPh3, R═R′=Cy, X=SO2Tol from the metallated ylide [Ph3PCSO2Tol]Na
- 2.05 g (4.5 mmol) of the metallated ylide [Ph3PCSO2Tol]Na was dissolved in 40 ml of THF and cooled down to −50° C. At this temperature, 1.13 ml (5.4 mmol) of dicyclohexylchlorophosphanes was slowly added to the yellow reaction solution, which finally bleached when warmed up to room temperature. After the solvent has been removed under vacuum, the colorless solid formed was taken up in 30 ml of toluene, and the suspension was filtered. Renewed reduction of the solvent resulted in the formation of a solid. The latter was filtered off, whereby the product could be obtained as a colorless solid (yield: 1.97 g, 3.2 mmol, 71%).
- 1H-NMR (250 MHz, THF-d8): δ=0.78-1.29 (m, 10H, CHCy), 1.47-1.79 (m, 10H, CHCy), 2.13-2.23 (m, 2H, CHCy), 2.31 (s, 3H, CHSTol), 6.90-7.10 (m, 4H, CHSTol, meta/ortho), 7.35-7.61 (m, 9H, CHPPh, meta/para), 7.65-7.78 (m, 6H, CHPPh, ortho). 31P{1H}-NMR (250 MHz, THF-d8): δ=−5.79 (d, 2JPP=164.3 Hz: PCy), 25.58 (d, 2JPP=164.4 Hz; PPh3). TEP=2055.1 cm−1.
- The preparation of the simple ylide-functionalized phosphanes was also effected according to this protocol, with:
- On=PPh3, X=SO2Tol, R═R′=Ph (T. Scherpf et al., Angew. Chem. Int. Ed., 54, 8542 (2015)), iPr, adamantyl or cyclohexyl
- On=PPh3, X═CN, R═R′=Ph, or Cy.
- In addition, the bis(ylide)-functionalized phosphane Y2PPh with On=PPh3 and X═CN was prepared according to this protocol.
- B) Preparation Through the Dichlorophosphane Intermediate (Route A)
- Preparation of the ylide-functionalized dimethylphosphane with On=PPh3, R═R′═Me, X=SO2Tol from the metallated ylide [Ph3PCSO2Tol]Na
- In a 50 ml Schlenk tube, 3.01 g (6.66 mmol) of the metallated ylide was dissolved in 35 ml of THF. Thereafter, 0.70 ml (1.10 g, 7.99 mmol) of phosphorus trichloride was quickly added dropwise and heated to boil for 5 min. After the reaction solution had been stirred over night, the solvent was removed under vacuum, and the solid was dissolved in dichloromethane. Subsequently, the suspension was filtered through a filter cannula, and the solvent was again removed under vacuum. The solid that had precipitated was washed with benzene, filtered off through a Schlenk frit, and dried under vacuum. The ylide-functionalized dichlorophosphane can thus be obtained as a colorless solid (yield: 2.88 g, 5.44 mmol, 82%).
- 1H-NMR (500.1 MHz, CD2Cl2): δ [ppm]=2.37 (s, 3H; CH3), 7.04-7.07 (m, 2H; CHTol,meta), 7.22-7.25 (m, 2H; CHTol,ortho), 7.49-7.55 (m, 6H; CHPPh,meta), 7.64-7.69 (m, 3H; CHPPh,para), 7.71-7.77 (m, 6H; CHPPh,ortho). 13C{1H}-NMR (125.8 MHz, CD2Cl2): δ [ppm]=21.5 (s, CH3), 62.9 (dd, 1JCP=111.8 Hz, 1JCP=91.8 Hz; CPCS), 124.1 (dd, 1JCP=92.8 Hz, 3JCP=3.6 Hz; CPPh,ipso), 129.1 (s, CHTol,meta), 129.2 (d, 3JCP=12.8 Hz; CHPPh,meta), 129.7 (d, 4JCP=1.9 Hz; CHTol,ortho), 133.5 (d, 4JCP=2.9 Hz; CHPPh,para), 135.2 (dd, 2JCP=10.2 Hz, 4JCP=1.9 Hz; CHPPh,ortho), 142.4 (s, CTol,para), 143.9 (S, CTol,ipso). 31P{1H}-NMR (162.0 MHz, CD2Cl2): δ [ppm]=19.7 (d, 2JPP=110.1 Hz), 159.2 (br).
- In a 50 ml Schlenk tube, 299 mg (0.56 mmol) of the ylide-functionalized dichlorophosphane was dissolved in 10 ml of THF, and 2.35 ml (1.13 mmol, 0.48 M) of methyllithium in THF was slowly added. After stirring the solution over night, the solvent was removed under vacuum, and the residue was dissolved in 15 ml of benzene. Thereafter, the suspension was filtered through a filter cannula, and the solvent was again removed under vacuum. After vacuum drying, the dimethylphosphane can be isolated as a colorless solid (0.38 g, 0.78 mmol; 82%).
- 1H-NMR (500.1 MHz, C6D6): δ [ppm]=1.70 (s, 6H; CH3,PMe), 1.96 (s, 3H; CH3,Tol), 6.74-6.75 (m, 2H; CHTol,meta), 6.96-6.99 (m, 6H; CHPPh,meta), 7.03-7.05 (n, 3H; CHPPh,para), 7.59-7.60 (m, 2H; CHTol,ortho), 7.75-7.77 (m, 6H; CHPPh,ortho). 13C{1H}-NMR (125.8 MHz, C6D6): δ [ppm]=16.0 (dd, 1JCP=13.9 Hz, 3JCP=6.5 Hz; CH3,PMe), 21.1 (s, CH3,Tol), 42.2 (dd, 1JCP=107.8 Hz, 1JCP=53.7 Hz; CPCS), 126.9 (s, CHTol,ortho), 128.3 (d, 3JCP=12.0 Hz; CHPPh,meta), 128.6 (s, CHTol,meta), 131.7 (d, 4JCP=2.8 Hz; CHPPh,para), 135.0 (dd, 2JCP=9.5 Hz, 4JCP=2.5 Hz; CHPPh,ortho), 139.8 (S, CTol,para), 148.5 (s, CTol,ipso). 31P{1H}-NMR (162.0 MHz, C6D6): δ [ppm]=−46.4 (d, 2JPP=146.5 Hz), 23.6 (d, 2JPP=146.5 Hz). TEP=2059.7 cm−1.
- The preparation of the simple ylide-functionalized phosphanes with On=PPh3, X=SO2Tol or CN, R═R′=Ph, Me, iPr or Cy was effected according to this protocol.
- In addition, the ylide-functionalized phosphane Y2PCy with On=PPh3 and X═CN was prepared according to this protocol.
- C) Preparation by Phosphorylation and Deprotonation of Onium Salts (Route B)
- The corresponding onium salts are either commercially available, or can be prepared by standard synthesis methods, such as the quaternization of corresponding phosphane, sulfide or amine precursors with alkyl halides and tosylates. The salts (such as A in the following Scheme) can be deprotonated with metal bases, such as potassium tert-butanolate, metal hydrides or lithium/sodium/potassium bis(trimethylsilyl)amide, and directly react with the halophosphane to form the phosphanyl-substituted onium salt (e.g., B). The latter can be converted to the desired ylide-functionalized phosphane with another equivalent of base without prior processing. Simple representatives can be obtained from the commercially available bis(diphenylphosphino)methane and bis(dicyclohexylphosphino)methane by quaternization with alkyl halides followed by deprotonation (J. Langer et al., ARKIVOC, 3, 210 (2012)). Other functionalizations can be realized according to the following Scheme. In particular, phosphanes, sulfides, amines, imines, N-heterocycles and sulfoxides have proven useful as the On moiety.
- D) Examples: Synthesis of a methyl- (Z=Me) and silyl-functionalized (Z═SiMe3) ylide phosphane
- The onium salt A (here: ethyltriphenylphosphonium iodide) with X=Me and Hal=I can be prepared according to known literature protocols (M. N. Alberti et al., Org. Lett., 10, 2465 (2008)), or can be purchased (CAS: 4736-60-1). The formation of the ylide-functionalized phosphane YMePCy2 with R=Cy is effected in accordance with:
- 190 g (4.50 mmol) of ethyltriphenylphosphonium iodide and 500 mg (12.5 mmol) of potassium hydride were added to 20 ml of THF. The suspension was heated at 60° C. for 4 hours, whereupon formation of hydrogen could not be observed any more. Subsequently, 1.60 g (5.0 mmol) of dicyclohexyliodophosphane was added dropwise, and the mixture was again heated at 60° C. for 16 hours. After the solvent had been removed under vacuum, 20 ml of hexane was added. The mixture was heated to the boiling point and filtered while still hot. The solvent was again removed under vacuum, and the residual solid was dissolved in as low as possible an amount of a 1:1 mixture of hexane and toluene. By storing the solution at −75° C. for three days, the desired phosphane could be isolated as an orange crystalline solid (1.63 g, 3.35 mmol, 74%).
- 1H NMR: (400.1 MHz, CD2Cl2): δ=1.20-1.59 (m, 10H, Cy), 1.70-1.89 (m, 6H, Cy), 1.89-2.07 (m, 4H, Cy), 2.11 (dd, 3H, 3JHP=16.3 Hz, 3JHP=2.4 Hz, CH3), 2.21-2.30 (m, 2H, Cy), 7.05-7.10 (m, 9H, CHPPh, ortho and CHPPh, para), 7.69-7.79 (m, 6H, CHPPh, meta), 31P{1H}-NMR: (162.1 MHz, CD2Cl2): δ=−2.44 (d, 2JPP=176.8 Hz, PCy2), 25.4 (d, 2JPP=176.8 Hz, PPh3). TEP: 2050.1 cm−1.
- The preparation of the ylide-functionalized phosphanes with On=PPh3, X=Et, CH2Ph, Cy, SiMe3, R═R′=Ph, Me or Cy was also effected according to this protocol.
- 2.00 g (4.20 mmol) of trimethylsilylmethylenephenylphosphonium iodide and 250 mg (6.23 mmol) of potassium hydride were added to 20 ml of THF. The suspension was stirred at room temperature for 16 hours, whereupon formation of hydrogen could not be observed any more. The yellow suspension was filtered, washed with 5 ml of THF, and transferred into a dropping funnel, and slowly added to a solution of dicyclohexyliodophosphane (1.5 g, 4.63 mmol) in 20 ml of toluene at −780° C. The solution was slowly heated to room temperature and then stirred for 24 h. The solid that had precipitated was filtered off and washed twice with 5 ml of toluene, and dried under vacuum. The solid and 670 mg of KHMDS (3.36 mmol) were dissolved in 20 ml of THF and stirred for 1 hour. The solid that had precipitated was removed by filtration, the solvent was removed under vacuum, and the residual solid was dissolved in 50 ml boiling hexane and filtered while still hot. The solution was slowly cooled down to RT and allowed to stand for 16 hours. The solution above the yellow crystals that had formed was removed, and the crystals were washed three times with 5 ml of cold hexane, followed by drying under vacuum (1.07 g, 1.98 mmol, 47%).
- 1H NMR: (400.1 MHz, C6D6): δ=0.28 (s, 6.3H, SiMe3, trans), 0.40 (s, 2.7H, SiMe3, cis), 0.89-2.25 (m, 20H, Cy), 2.34-2.60 (m, 2H, Cy), 7.02-7.11 (m, 9H, CHPPh, ortho and CHPPh, para), 7.73-7.82 (m, 6H, CHPPh, meta), 31P{1H}-NMR: (162.1 MHz, C6D6): δ=8.3 (d, 2JPP=37.2 Hz, PCy2, cis), 12.8 (d, 2JPP=172.2 Hz, PCy2, trans), 19.7 (d, 2JPP=37.2 Hz, PPh3, cis), 29.1 (d, 2JPP=172.2 Hz, PPh3, trans), TEP: 2048.9 cm−1.
- 4.00 g (10 mmol) of ethyltriphenylphosphonium iodide and 600 mg (15 mmol) of potassium hydride were added to 20 ml of THF. The suspension was stirred at room temperature for 16 hours, whereupon formation of hydrogen could not be observed any more. The red suspension was filtered, washed with 5 ml of THF, and transferred into a dropping funnel, and slowly added dropwise to a solution of cyclohexyldichlorophosphane (460 mg, 2.5 mmol) in 20 ml of THF with vigorous stirring. The solution was stirred at RT for 16 hours. The solid that had precipitated was filtered off and washed twice with 10 ml of THF. The solvent of the red solution obtained was removed under vacuum, and the solid obtained was dried under vacuum. 20 ml of cyclohexane was added, the mixture was heated to boil, filtered while still hot, and then slowly cooled down to RT, wherein a red solid precipitated. The supernatant solution was removed, and the solid was washed twice with 2 ml of pentane and dried under vacuum (0.68 g, 0.98 mmol, 39%).
- 1H NMR: (400.1 MHz, C6D6): δ=1.17-1.36 (m, 3H, Cy,), 1.47-1.60 (m, 2H, Cy,), 1.70-1.80 (m, 1H, Cy,), 1.84-1.94 (m, 2H, Cy,), 2.22-2.32 (m, 2H, Cy), 2.52 (dd, 3JHP=17.4 Hz, 3JHP=2.0 Hz 6H, Me), 2.75-2.86 (m, 1H, Cy), 7.98-7.04 (m, 12H, CHPPh, ortho), 7.04-7.11 (m, 6H, CHPPh, para), 7.62-7.70 (m, 12H, CHPPh, meta), 31P{1H}-NMR: (162.1 MHz, C6D6): =−20.3 (t, 2JPP=175.1 Hz, PCy), 19.5 (d, 2JPP=175.1 Hz, PPh3)
- In a Schlenk flask, 10.0 g (22.9 mmol) of ethyltricyclohexylphosphonium iodide was suspended in 75 ml of THF. The Suspension was cooled in an ice bath to 0° C., 14.5 ml (22.9 mmol) of a 1.58 M solution of n-BuLi in hexanes was slowly added dropwise. The solution, which was clear now, was warmed up to room temperature, and 2.45 ml (2.67 g, 11.5 mmol) of dicyclohexylphosphane chloride was added. A colorless solid precipitated immediately, and the suspension was heated at 60° C. for 16 hours. The colorless solid was filtered off and washed twice with 20 ml each of THF, and stored under argon. The filtrate was dried under vacuum, and the resulting solid was dissolved in 100 ml of cyclohexane, filtered, and the cyclohexane was again removed under vacuum. After drying under vacuum, the product could be isolated as a colorless solid (4.93 g, 9.77 mmol, 85%).
- 1H NMR (400 MHz, C6D6) δ=1.08-1.23 (m, 9H, CH2, PCy3, H3+H4), 1.32-1.43 (m, 2H, CH2, PCy2, H4), 1.43-1.58 (m, 12H, CH2, PCy3, H2+PCy2, H2+H3), 1.58-1.66 (m, 5H, CH2, PCy3, H4+PCy2, H2), 1.67-1.79 (m, 6H, CH2, PCy3, H3), 1.76-1.83 (m, 2H, CH2, PCy2, H4), 1.82-1.96 (m, 11H, CH2, PCy3, H2+PCy2, H2+CH3), 1.95-2.09 (m, 4H, CH2, PCy3, H3+CH, PCy2, H1), 2.11-2.23 (m, 2H, CH2, PCy2, H2), 2.23-2.34 (m, 2H, CH2, PCy2, H3), 2.34-2.52 (m, 3H, CH, PCy3, H1) ppm. 13C {1H} NMR (101 MHz, C6D6) δ=−1.7 (dd, 1JCP=108.8 Hz, 1JCP=21.1 Hz, P—C−—P), 14.8 (dd, 2JCP=8.4 Hz, 2JCP=0.7 Hz, CH3), 26.6-27.0 (m, CH2, PCy3, C4), 27.7-27.8 (m, CH2, PCy2, C4), 27.8 (d, 3JCP=11.0 Hz, CH2, PCy3, C3), 28.0-28.4 (m, CH2, PCy3, C2), 28.5 (d, 3JCP=11.8 Hz, CH2, PCy2, C3), 29.0 (d, 3JCP=8.1 Hz, CH2, PCy2, C3), 32.9 (d, 2JCP=9.9 Hz, CH2, PCy2, C2), 33.67 (dd, 1JCP=49.5 Hz, 3JCP=8.9 Hz, CH, PCy3, C1) 33.69 (d, 2JCP=19.8 Hz, CH2, PCy2, C2), 38.4 (dd, 1JCP=13.8 Hz, 3JCP=5.3 Hz, CH, PCy2, C1) ppm. 31P {1H} NMR (162 MHz, C6D6) δ=1.0 (d, 2JPP=128.9 Hz, PCy2), 30.6 (d, 2JPP=128.9 Hz, PCy3) ppm. CHNS: calculated: C: 76.14, H: 11.58. measured: C: 75.62, H: 11.32.
- Recovery of Ethyltricyclohexylphosphonium Iodide
- The colorless solid remaining after the washing with THF was dried under vacuum and dissolved in 15 ml of DCM. The solution was filtered, and the solvent was removed under vacuum, and dried. Ethyltricyclohexylphosphonium iodide was obtained as a colorless solid (4.27 g, 9.8 mmol, 85%).
- In a Schlenk flask, 2.55 g (5.84 mmol) of ethyltricyclohexylphosphonium iodide was suspended in 25 ml of THF. The suspension was cooled in an ice bath to 0° C., and 2.78 ml (5.84 mmol) of a 2.1 M solution of n-BuLi in hexanes was slowly added dropwise. The solution, which was clear now, was warmed up to room temperature. 0.55 ml (0.53 g, 2.92 mmol) of di-tert-butylchlorophosphane was added, and the mixture was heated at 60° C. for 16 hours. The colorless solid was filtered off and washed twice with 5 ml each of THF. The filtrate was dried under vacuum, and the resulting solid was dissolved in 50 ml of cyclohexane. After renewed filtration, the solvent was removed under vacuum, and the product was isolated as a colorless solid (1.32 g, 1.51 mmol, 52%; non-optimized yield).
- 1H NMR (400 MHz, C6D6) δ=1.08-1.24 (m, 9H, CH2, Cy, H3+H4), 1.54 (d, 3JHP=10.7 Hz, 18H, CH3, tBu), 1.44-1.67 (m, 9H, CH2, Cy, H2+H4), 1.63-1.76 (m, 6H, CH2, Cy, H3), 2.04 (d, 3JPH=13.0 Hz, 6H, CH2, Cy, H2), 2.11 (dd, 3JHP=13.8 Hz, 3JHP=3.1 Hz, 3H, CH3), 2.16-2.32 (m, 3H, CH, Cy, H1) ppm. 13C {1H} NMR (101 MHz, C6D6) δ=4.5 (dd, 1JCP=102.9 Hz, 1JCP=27.3 Hz, P—C−—P), 18.2 (dd, 2JCP=8.6 Hz, 2JCP=0.6 Hz, CH3), 27.0 (CH2, Cy, C4), 28.2 (d, 3JCP=10.6 Hz, CH2, Cy, C3), 29.6-29.8 (m, CH2, Cy, C2), 33.3 (d, 2JCP=14.4 Hz, CH3, tBu), 36.5 (dd, 1JCP=23.4 Hz, 1JCP=6.6 Hz, C,tBu) 37.0 (dd, 1JCP=47.9 Hz, 3JCP=9.0 Hz, CH, Cy, ci) ppm. 31P {1H} NMR (162 MHz, C6D6) δ=26.4 (d, 2JPP=146.9 Hz, PtBu2), 30.4 (d, 2JPP=146.9 Hz, PCy3) ppm.
- In a Schlenk tube, 500 mg (1.11 mmol) of benzyltricyclohexylphosphonium iodide was weighed and suspended in 10 mL of THF. To the suspension, 0.51 ml (1.11 mmol; 1 eq.) of an n-BuLi solution (2.18 M in hexane) was slowly added dropwise until a clear solution had formed. The solution was stirred for 45 min, and subsequently 0.32 ml (335 mg; 1.44 mmol; 1.3 eq.) of Cy2PCl was added. The suspension was stirred at room temperature for 16 hours. The solid was filtered off and washed twice with 10 ml each of THF, und dried under high vacuum for 1.5 hours (558 mg). The solid obtained as well as 133 mg (1.19 mmol) of potassium tert-butanolate were weighed in a Schlenk tube and suspended in 20 ml of dry toluene. The suspension was stirred for 16 hours and then filtered off. The solid was washed twice with 10 ml of toluene. The solvent of the filtrate was removed under vacuum, and the product was obtained as a colorless solid (0.35 g, 0.62 mmol, 56%; non-optimized yield).
- 1H NMR (400 MHz, Tol-d) δ=1.00-1.22 (m, 9H, CH2, PCy3, H3+H4), 1.22-1.64 (m, 19H, CH2, PCy2, H2+H3+H4 PCy3, H2, H3), 1.64-1.83 (m, 12H, CH2, PCy2, H3+H4 PCy3, H3), 1.83-2.01 (m, 10H, CH2, PCy2, H2 PCy3, H2), 2.33-2.46 (m, 5H, CH, PCy2, H1, PCy3, H1), 6.97-7.00 (m, 1H, CH, Ph, para), 7.18-7.25 (m, 2H, CH, Ph, meta), 7.34-7.40 (m, 2H, CH, Ph, ortho) ppm. 31P{1H}-NMR (162.1 MHz, Tol-d): δ [ppm]=−5.4 (d, 2JPP=132.0 Hz, PtBu2), 21.5 (d, 2JPP=132.0 Hz,) ppm.
- A) Nickel Carbonyl Complexes
- By way of example, the synthesis of the complex with the ylide-functionalized phosphane with On=PPh3, R═R′=Me, X=SO2Tol as prepared in Example 1.B) is described below.
- In a 30 ml Schlenk tube, 0.10 g (0.20 mmol) of the phosphane was suspended in 5 ml of pentane. Thereafter, 0.43 ml (0.31 mmol) of 0.7 M nickel tetracarbonyl in benzene was quickly added dropwise, and the reaction mixture was stirred at room temperature for 2 hours. Subsequently, the solvent was removed by means of a cannula, and the solid was washed twice with 5 ml each of pentane. After removing the solvent and drying under vacuum, the complex was obtained as a grayish solid (79.1 mg, 0.13 mmol, 61%).
- 1H-NMR (500.1 MHz, CD2Cl2): δ [ppm]=1.97 (d, 2JPH=4.70 Hz, 6H; CH3,PMe), 2.30 (s, 3H; CH3,Tol), 6.93-6.95 (m, 2H; CHTol,meta), 7.16-7.17 (m, 2H; CHTol,ortho), 7.38-7.42 (m, 6H; CHPPh,meta), 7.53-7.58 (m, 9H; CHPPh,ortho+para). 13C{1H}-NMR (125.8 MHz, CD2Cl2): δ [ppm]=21.4 (s, CH3,Tol), 23.4 (dd, 1JCP=26.8 Hz, 3JCP=3.5 Hz; CH3,PMe), 39.1 (dd, 1JCP=105.6 Hz, 1JCP=3.2 Hz; CPCS), 125.9 (s, CHTol,ortho), 126.9 (dd, 1JCP=91.5 Hz, 3JCP=1.9 Hz; CPPh,ipso), 128.8 (d, 3JCP=12.4 Hz; CHPPh,meta), 129.0 (s, CHTol,meta), 132.8 (d, 4JCP=3.0 Hz; CPPh,para), 135.1 (d, 2JCP=9.8 Hz; CHPPh,ortho), 140.7 (S, CTol,para), 146.7 (dd, 3JCP=1.21 Hz, 3JCP=1.2 Hz; CHTol,ipso), 196.2 (S, CCO). 31P{1H}-NMR (162.0 MHz, CD2Cl2): δ [ppm]=−11.8 (d, 2JPP=75.6 Hz), 20.3 (d, 2JPP=75.6 Hz). Elemental analysis: measured: C, 58.41; H, 4.51; S, 4.97. calculated: C, 58.80; H, 4.46; S, 5.06.
- B) Gold Chloride Complexes
- By way of example, the synthesis of the complex with the ylide-functionalized diphenylphosphane with On=PPh3, R═R′=Ph, X=SO2Tol as prepared in Example 1.A) is described below.
- In a 50 ml Schlenk tube, 0.20 g (3.26 mmol) of the phosphane and 0.11 g (3.26 mmol) of (THT)AuCl (THT=tetrahydrothiophene) were dissolved in 5 ml of THF, and the reaction mixture was stirred at room temperature over night to form a colorless precipitate. The solid was filtered off through a Schlenk frit and dried under vacuum to obtain the desired gold complex (0.32 g, 0.38 mmol, 77%).
- 1H-NMR (500.1 MHz, CD2Cl2): δ [ppm]=2.27 (s, 3H; CH3), 6.20-6.23 (m, 2H; CHTol,ortho), 6.70-6.72 (m, 2H; CHTol,meta), 7.41-7.51 (m, 12H; CHPPh,ortho+meta), 7.61-7.62 (m, 2H; CHAuPPh,para), 7.63-7.66 (m, 7H; CHAuPPh,meta+PPh,para), 7.86-7.90 (m, 4H; CHAuPPh,ortho). 13C{1H}-NMR (125.8 MHz, CD2Cl2): δ [ppm]=21.3 (s, CH3), 42.8 (dd, 1JCP=101.4 Hz, 1JCP=57.6 Hz; CPCS), 126.0 (dd, 1JCP=86.9 Hz, 3JCP=8.8 Hz; CPPh,ipso), 126.0 (s, CHTol,ortho), 128.5 (dd, 2JCP=11.7 Hz, 4JCP=0.8 Hz; CHPPh,ortho), 128.9 (s, CHTol,meta), 129.1 (d, 3JCP=12.5 Hz; CPPh,meta), 131.1 (d, 4JCP=2.6 Hz; CHAuPPh,para), 133.4 (d, 4JCP=2.8 Hz; CHPPh,para), 133.4 (dd, 1JCP=63.0 Hz, 3JCP=8.2 Hz; CAuPPh,ipso), 135.2 (d, 3JCP=13.6 Hz; CHAuPPh,meta), 135.4 (dd, 2JCP=9.2 Hz, 4JCP=1.2 Hz; CHAuPPh,ortho), 141.7 (S, CTol,para), 144.4 (s, CHTol,ipso). 31P{1H}-NMR (162.0 MHz, CD2Cl2): δ [ppm]=21.4 (d, 2JPP=68.3 Hz), 22.1 (d, 2JPP=68.3 Hz). Elemental analysis: measured: C, 54.19; H, 3.90; S, 3.68. calculated: C, 53.88; H, 3.81; S, 3.78.
- All the gold-phosphane complexes used in the catalysis (see below) were prepared according to this protocol.
- C) Palladium Allyl Complexes
- By way of example, the synthesis of three palladium allyl complexes of the ylide-substituted phosphanes is described here. Complexes with more ligands other than those stated here can be prepared according to the stated protocol.
- Synthesis of the complex with the ylide-functionalized diphenylphosphane with On=PPh3, R═ R′=Ph, X═SO2Tol as prepared in Example 1.A):
- In a 50 ml Schlenk tube, 201 mg (0.325 mmol) of the phosphane and 59 mg (0.163 mmol) of the allylpalladium(II) chloride dimer were dissolved in 10 ml of dichloromethane, and stirred at room temperature for 1 hour. The solvent was subsequently reduced to 1 ml under vacuum, and the mixture was admixed with pentane until a solid precipitated. The latter was filtered off through a Schlenk frit and subsequently dried under vacuum to obtain the palladium complex as a brownish solid (163 mg, 0.21 mmol, 63%).
- 1H-NMR (500.1 MHz, CD2Cl2): δ [ppm]=1.8-2.5 (br, 2H; CH2,ally), 2.22 (s, 3H; CH3), 2.76 (br, 1H; CH2,allyl), 4.12 (m, 1H; CH2,allyl), 4.84 (br, 1H; CHallyl), 6.71-6.73 (m, 2H; CHTol,meta), 6.76-6.78 (m, 2H; CHTol,ortho), 7.16-7.18 (m, 4H; CHPdPPh,meta), 7.22-7.25 (m, 2H; CHPdPPh,para), 7.41-7.45 (m, 6H; CHPPh,meta), 7.53-7.57 (m, 3H; CHPPh,para), 7.84-7.88 (m, 4H; CHPdPPh,ortho), 7.97-8.01 (m, 6H; CHPPh,ortho). 13C{1H}-NMR (125.8 MHz, CD2Cl2): δ [ppm]=21.3 (s, CH3), 42.3 (dd, 1JCP=105.2 Hz, 1JCP=20.4 Hz; CPCS), 64.7 (br; CH2,allyl), 78.3 (d, 2JCP=31.8 Hz; CH2,allyl), 117.7 (d, 2JCP=4.3 Hz; CHallyl), 126.5 (s, CHTol,ortho), 127.4 (d, 2JCP=10.3 Hz; CHPdPPh,meta), 128.3 (dd, 1JCP=94.0 Hz, 3JCP=1.2 Hz; CPPh,ipso), 128.4 (dd, 1JCP=55.1 Hz, 3JCP=12.4 Hz; CHPdPPh,ipso), 128.5 (s, CHTol,meta), 128.5 (d, 3JCP=12.8 Hz; CHPPh,meta), 129.4 (d, 4JCP=2.0 Hz; CHPdPPh,para), 132.3 (d, 4JCP=3.0 Hz; CHPPh,para), 135.2 (d, 2JCP=10.5 Hz; CHPdPPh,ortho), 136.2 (d, 2JCP=10.1 Hz; CHPPh,ortho), 140.9 (S, CTol,para), 144.2 (S, CTol,ipso). 31P{1H}-NMR (162.0 MHz, CD2Cl2): δ [ppm]=9.9 (d, 2JPP=67.3 Hz), 22.9 (d, 2JPP=67.3 Hz).
- Synthesis of the complex with the ylide-functionalized dicyclohexylphosphane with On=PCy3, R═R′=Cy, X=Me as prepared in Example 1.D):
- The phosphane Y*MePCy2 (300 mg, 0.60 mmol) and allylpalladium(II) chloride dimer (109 mg, 0.30 mmol) were dissolved in 7 ml of toluene and stirred until a clear solution had formed. Stirring was discontinued, and the solution was stored at room temperature for 3 days. Yellow crystals slowly formed, which were separated from the solvent, then washed three times with 5 ml of pentane, and dried under vacuum (230 mg, 0.33 mmol, 56%; non-optimized yield).
- Numbering Scheme
- 1H NMR (400 MHz, CD212) δ=1.12-1.58 (m, 25H, CH2, PCy3+PCy2), 1.62 (dd, 3JHP=12.4 Hz, 3JHP=8.3 Hz, 3H, CH3), 1.67-2.05 (m, 25H, CH2, PCy3+PCy2), 2.10-2.24 (m, 2H, CH, PCy2, H1), 2.43-3.70 (vbr, 2H, CH2, C3H5), 2.54-2.72 (m, 3H, CH, PCy3, H1), 3.54 (dd, 2JHH=13.7 Hz, 3JHH=8.5 Hz, 1H, CH2, C3H5), 4.25-4.40 (m, 1H, CH2, C3H5), 5.19-5.41 (m, 1H, CH, C3H5) ppm. 13C {1H} NMR (101 MHz, CD2Cl2) δ=−2.7 (dd, 1JCP=112.1, 1JCP=46.8 Hz, P—C−—P), 16.4 (m, CH3), 26.9 (d, 4JCP=1.5 Hz, CH2, PCy3, C4), 27.2-27.5 (m, CH2, PCy2, C4), 27.8 (d, 3JCP=13.4 Hz, CH2, PCy2, C3), 28.1 (d, 3JCP=11.3 Hz, CH2, PCy3, C3), 28.60 (d, 3JCP=9.9 Hz, CH2, PCy2, C3), 28.63 (d, 2JCP=2.6 Hz, CH2, PCy3, C2), 30.0-30.5 (m, CH2, PCy2, C2), 31.2 (d, 2JCP=5.2 Hz, CH2, PCy2, C2), 32.7-36.6 (m, CH, PCy2, C1), 38.4-39.6 (br, CH, PCy3, C1), 52.5-52.9 (m, CH2, C3H5), 79.5 (d, 2JCP=28.4 Hz, CH2, C3H5), 114.9 (d, 2JCP=4.4 Hz, CH, C3H5) ppm. 31p {1H} NMR (162 MHz, CD2Cl2) δ=20.5 (d, 2JPP=63.5 Hz, PCy2), 31.5 (d, 2JPP=63.5 Hz, PCy3) ppm. CHNS: calculated: C: 61.13, H: 9.23. measured: C: 61.03, H: 9.34.
- Synthesis of the complex with the ylide-functionalized phosphane with On=PCy3, R═R′=tBu, X=Me as prepared in Example 1.D):
- The phosphane Y*MePtBu2 (300 mg, 0.66 mmol) and allylpalladium(II) chloride dimer (115 mg, 0.32 mmol) were dissolved in 10 ml of toluene and stirred at room temperature for 16 hours. An orange solid formed, which was filtered off, washed with 10 ml of toluene and then dried under vacuum (265 mg, 0.42 mmol, 66%).
- 1H NMR (400 MHz, CD2Cl2) δ=1.02-1.56 (m, 15H, CH2, Cy, H2+H3+H4), 1.21 (d, 3JHP=13.0 Hz, 9H, CH3, tBu), 1.47 (d, 3JHP=13.3 Hz, 9H, CH3, tBu), 1.57-1.67 (m, 3H, CH2, Cy, H4), 1.68-1.89 (m, 9H, CH2, Cy, H3+CH3), 1.84-1.99 (br, 3H, CH2, Cy, H2), 2.08-2.20 (br, 3H, CH2, Cy, H2), 2.69-2.99 (br, 3H, CH, Cy, H1), 2.91-3.85 (vbr, 2H, CH2, C3H5), 3.56 (dd, 2JHH=13.5 Hz, 3JHH=8.4 Hz, 1H, CH2, C3H5), 4.27-4.35 (m, 1H, CH2, C3H5), 5.16-5.62 (m, 1H, CH, C3H5). 13C {1H} NMR (101 MHz, CD2Cl2) δ=4.0 (dd, 1JCP=105.1 Hz, 1JCP=41.3 Hz, P—C−—P), 18.0-19.5 (m, CH3), 26.9 (d, 4JCP=1.5 Hz, CH2, PCy3, C4), 27.9 (d, 3JCP=12.4 Hz, CH2, Cy, C3), 28.4 (d, 3JCP=11.0 Hz, CH2, Cy, C3), 29.0 (CH2, Cy, C2), 29.6 (CH2, Cy, C2), 31.6 (CH3, tBu), 32.9 (CH3, tBu), 34.4 (d, 1JCP=48.1 Hz, CH, Cy, C1), 42.0-42.3 (m, C,tBu), 56.3 (d, 2JCP=2.4 Hz, CH2, C3H5), 79.1-79.7 (m, CH2, C3H5), 113.7 (CH, C3H5) ppm. 31P {1H} NMR (162 MHz, CD2Cl2) δ=30.8 (d, 2JPP=63.4 Hz, PCy3), 58.0 (br, PtBu2) ppm. CHNS: calculated: C: 58.58, H: 9.36. measured: C: 58.85, H: 9.31.
- D) Palladium(0) Complexes and their Oxidative Addition Products
- By way of example, the synthesis of the palladium dibenzylidene acetone complex with the ylide-functionalized dicyclohexylphosphane with On=PCy3, R═R′=Cy and X=Me as prepared in Example 1.D) is described here. Analogous palladium complexes can be synthesized with other phosphane ligands according to corresponding protocols.
- A J. Young NMR tube was filled with 30 mg (59 μmol) of the phosphane Y*MePCy2 and 34 mg (59 μmol) of tris(dibenzylideneacetone)dipalladium(0) x dibenzylideneacetone. Both solids were suspended in 0.6 ml of deuterated THF and shaken for 30 minutes. The reaction was monitored by NMR spectroscopy, and after the reaction was complete, the product was crystallized by slowly diffusing pentane into the THF solution. The product could be obtained in the form of red crystals (45 mg; 53 μmol; 89%). When an excess of phosphane ligand is used, the bisphosphane palladium(0) complex can also be isolated.
- 31P {1H} NMR (162 MHz, THF-d) 5=26.9 (d, 2JPP=82.1 Hz, PCy2), 31.6 (d, 2JPP=82.1 Hz, PCy3). 1H NMR (400 MHz, THF-d8) δ=1.02-1.86 (m, 50H), 1.53 (dd, 2JHP=12.6 Hz, 2JHP=7.2 Hz, 3H), 1.87-2.06 (m, 2H, CH, PCy2, H1), 2.09-2.32 (m, 3H, CH, PCy3, H1), 5.97-6.17 (m, 2H, dba), 6.35-6.73 (m, 2H, dba), 7.10-7.31 (m, 8H, dba), 7.30-7.43 (m, 8H, dba), 7.49-7.63 (m, 4H, dba), 7.63-7.73 (m, 8H, dba), 7.73-7.79 (m, 2H, dba).
- By way of example, the synthesis of a palladium(II) arylchlorido complex with the ylide-functionalized dicyclohexylphosphane with On=PCy3, R═R′=Cy and X=Me as prepared in Example 1.D) is described here. Other palladium(II) complexes can be synthesized by analogy with all other phosphane ligands and with further aryl chlorides and bromides.
- Phosphane Y*MePCy2 (500 mg, 0.99 mmol, 1 eq.) and bis(dibenzylideneacetone)-palladium(0) (742 mg, 1.09 mmol) were stirred at RT in 10 ml of THF for 30 minutes. The solution was filtered, and 1 ml of p-chlorotoluene was added, and the solution was stirred for 48 hours. The dark yellow precipitate was filtered off and washed three times with 10 ml of THF. After drying under vacuum, the product was obtained as a dark yellow solid (515 mg, 0.69 mmol, 70%). The complex proved to be unsoluble in all common solvents except DCM, in which it slowly decomposes, however.
- 31P {1H} NMR (162 MHz, CD2Cl2) δ=32.5 (d, 2JPP=49.6 Hz), 35.1 (d, 2JPP=49.6 Hz) ppm. 1H NMR (400 MHz, CD2Cl2) δ=0.95-2.08 (m, 52H, CH+CH2, PCy2+PCy3), 1.55 (dd, 3JHP=12.8 Hz, 3JHP=9.4 Hz, 3H, CH3), 2.14 (s, 3H, CH3, Tolyl), 2.57 (br, 3H, CH, PCy3, H1), 6.68 (m, 2H, CH, Tolyl), 7.08 (m, 2H, CH, Tolyl) ppm.
- A) Gold-Catalyzed Hydroamination of Alkynes
- For this purpose, the phosphane gold chloride complexes prepared according to the protocol of Example 2B) were dissolved in a 1:1 mixture of alkyne and amine, and one equivalent of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate was added. The mixture was reacted under the conditions as stated in the Table below, in which the following conversion rates and yields were obtained. The catalysis did not show any decrease in yield under aqueous conditions, or upon exposure of the reaction mixture to air.
-
TABLE 2 Gold(I)-catalyzed hydroamination of phenylacetylene with aniline and ylide-functionalized phosphanes Amount of Catalyst catalyst reaction Temp. Yielda Charge L•AuCl; L = [mole %] time [h] [° C.] [%] 1 PPh3 5 18 RT 20b 2 YSPPh2 5 0.25 RT 70 3 YSPPh2 1 0.25 RT 63 4 YSPPh2 1 6 RT 99 5 YSPPh2 0.1 2.5 50 66 6 YSPPh2 0.1 5 50 82 isolated 6 YSPPh2 0.1 14 50 94 7 YSPPh2 0.05 22 50 59 8 YSPPh2 0.01 22 50 28 6 —[a] — 24 50 — 7 YSPMe2 0.1 24 50 90 8 YSPMe2 0.05 24 50 76 9 YSPCy2 1 0.25 RT 98 10 YSPCy2 0.1 6 RT 61 11 YSPCy2 0.1 22 RT 94 12 YSPCy2 0.1 5 50 95 13 YSPCy2 0.05 5 50 89 14 YSPCy2 0.05 22 50 99 15 YSPCy2 0.025 22 50 91 16 YSPCy2 0.01 22 50 51 17 YSPCy2 0.01 48 50 74 18 YSPCy2 0.005 22 80 50 19 YSPCy2 0.005 48 80 62 20 YSiPCy2 0.1 2 50 97 aThe yield was determined by NMR spectroscopy. bD. Malhotra et al. Angew. Chem. Int. Ed. 53, 4456 (2014). - B) Gold-Catalyzed Intramolecular Addition of O—H to Alkynes
- In addition to hydroamination, OH additions to alkynes can also be effected. Thus, 4-pentynoic acid in THF reacts at room temperature with 0.5 mole % YSPCy2.AuCl and an equimolar amount of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate completely to the desired lactone within 14 hours.
- C) Pd-Catalyzed C—N Couplinq Reaction
- The C—N coupling reaction of amines and haloaromatics was performed with the respective ylide-substituted phosphanes according to known synthesis protocols. The commercially available palladacycle di-p-chlorobis[2′-(amino-N)[1,1′-biphenyl]-2-yl-C]dipalladium(II) was used as a palladium precursor, and reacted with 1 equivalent of the phosphane ligand in THF. With the addition of sodium tert-butanolate, the amine and the bromo- or chloroaromatic were made to react.
-
TABLE 3 C—N coupling of phenylaniline with aryl bromides and chlorides with the phosphane ligand YMePCy2. Amount of Catalyst; catalyst Reaction Temp. Yielda Charge Ligand = [mole %] Aryl halides time [h] [° C.] [%] 1 YMePCy2 5 2-Bromotoluene 16 RT 99 2 YMePCy2 5 4-Chlorobenzo- 16 RT 40 nitrile 3 YMePCy2 5 4-Chlorobenzo- 16 60 95 nitrile 4 YMePCy2 2.5 4-Chlorotoluene 18 100 17 5 YMePCy2 2.5 4-Chlorotoluene 48 100 39 aThe yield was determined by NMR spectroscopy. - In a glove box, 1.5-2.0 equivalents of potassium tert-butanolate (or sodium tert-butanolate) was added to a screw-cap vessel. Outside the glove box, the aryl chloride (0.9-1.2 mmol) and 1.1 eq. of an amine as well as 2 ml of solvent were added. In a second vessel, a catalyst solution (see below) was prepared, and the corresponding amount of catalyst was added to the reaction. The reaction mixture was stirred at room temperature. After the period as stated in the Table, the reaction was quenched with water, and the product was isolated by column chromatography. Alternatively, yields were determined by NMR spectroscopy. trifluorotoluene in the case of p-fluorochlorobenzene, and 1,3,5-trimethoxybenzene in the case of the fluorine-free chloroaromatics, were used as internal standards. For a determination after defined reaction times, small amounts of the reaction solution were withdrawn and quenched with a little water. The organic phase was taken off, filtered, and the solvent was removed. The residue was dissolved in CDCl3, and the conversion was determined by means of the ratio of product peak to internal standard.
- In an analogous way, aryl bromides can be employed in the coupling reactions.
- Catalyst preparation:
-
- 1) The ligand L1 (or L2-L6) and an equimolar amount of bis(di-benzylideneacetone)palladium(0) (or Pd(OAc)2) were dissolved in THF (or dioxane, or toluene; see Table), and stirred at room temperature for 30 minutes. An appropriate amount of the solution was subsequently added to the reaction vessel.
- 2) The precatalysts P1, P2, P4-P8 were dissolved in THF and stirred at room temperature for 30 minutes. An appropriate amount of the solution was subsequently added to the reaction vessel.
- 3) The corresponding amount of precatalyst P3 was directly added to the reaction solution.
- Comparison of the Catalytic Activity of the Ligands with Known Ligand Systems
-
R (Pre)catalyst Base Solvent Yield [%][a] Me L1•Pd2dba3 KOtBu THF 95 Me L1•Pd2dba3 NaOtBu THF 52 Me L1•Pd2dba3 KOtBu dioxane 99 F L1•Pd2dba3 KOtBu THF 83 F L1•Pd2dba3 NaOtBu THF 45 F L1•Pd2dba3 KOtBu dioxane 88 F L1•Pd(OAc)2 KOtBu THF 87 F P4 or P5 or P6 or KOtBu THF <1 P7 or P8 F L3 or L4 or L5 KOtBu THF <1 with Pd2dba3 F L6•Pd(OAc)2 [b] NaOtBu toluene 10 (84)[c] F L1•Pd(OAc)2 [b] NaOtBu toluene 78 (88)[c] [a]Yields were determined by NMR spectroscopy. [b]1 mole % of ligand. [c]After 19 h. - Application of Different Aryl Chlorides with P*MePCy2 (L1) as Ligands
- Yields are isolated yields.
- Application of Different Amines and Catalyst Systems Based on P*MePCy2 (L1) and P*MePtBu2 (L2)
-
Catalyst: L1•Pd2dba3 Amine 1 h 3 h 6 h 24 h n-Butylamine 41% 49% 51% 60% Piperidine >99% — — — iso-Propylamine 15% 20% 22% 27% tert-Butylamine 28% 83% >99% — Diethylamine 48% 60% 67% 67% N-Methylaniline >99% — — — Catalyst: L2•Pd2dba3 Amine 1 h 3 h 6 h 24 h n-Butylamine 53% 77% 92% >99% Piperidine 10% 23% 49% 63% iso-Propylamine 17% 27% 30% 43% tert-Butylamine <1% 3% 5% 9% Diethylamine <1% 3% 5% 23% N-Methylaniline 6% 10% 15% 57% Catalyst: P1 Amine 1 h 3 h 6 h 24 h n-Butylamine 37% 44% 44% 51% Piperidine >99% — — — iso-Propylamine 15% 17% 20% 23% tert-Butylamine 16% 21% 31% 34% Diethylamine 50% 78% 93% 98% N-Methylaniline >99% — — — Catalyst: P2 Amine 1 h 3 h 6 h 24 h n-Butylamine >99% — — — Piperidine >99% — — — iso-Propylamine 54% 54% 57% 61% tert-Butylamine 18% 18% 19% 20% Diethylamine 46% 54% 60% 64% N-Methylaniline >99% — — — Catalyst: P3 AminE 1 h 3 h 6 h 24 h n-Butylamine 44% 61% 62% 64% Piperidine >99% — — — iso-Propylamine 13% 19% 20% 25% tert-Butylamine 37% >99% — — Diethylamine 61% 63% 63% 68% N-Methylaniline >99% — — — - D) Pd-Catalyzed C—C Coupling Reaction
- The C—C coupling reaction of boronic acid and haloaromatics was performed with the respective ylide-substituted phosphanes according to known synthesis protocols. The commercially available palladacycle di-p-chlorobis[2′-(amino-N)[1,1′-biphenyl]-2-yl-C]dipalladium(II) was used as a palladium precursor, and reacted with 1 equivalent of the phosphane ligand in THF. With the addition of an aqueous solution of potassium phosphate, the amine and the bromo- or chloroaromatic were made to react.
-
TABLE 4 C—C coupling of phenylboronic acid with aryl bromides and chlorides with the phosphane ligands YmePCy2 and YSPCy2. Amount of Reaction Catalyst; catalyst time Temp. Yielda Charge Ligand = [mole %] Aryl halides [h] [° C.] [%] 1 YSPCy2 2 2-Bromotoluene 24 RT 60 2 YMePCy2 2 2-Bromotoluene 24 RT 16 3 YMePCy2 5 2-Bromotoluene 24 60 99 4 YMePCy2 2 4-Bromo- 48 RT 84 acetophenone 5 YMePCy2 5 4-Chlorotoluene 24 60 27 6 YMePCy2 5 4-Chloro- 24 60 95 benzonitrile aThe yield was determined by NMR spectroscopy. - Heck Reaction with YPhos
- In a glove box, potassium carbonate was added to a Schlenk vessel with a stirring rod. 2 ml of dry DMF (dimethylformamide), aryl halide (1.1 mmol) and olefin (2.1 mmol) were added.
- A stock solution of catalyst and ligand was prepared by mixing 0.2 mmol palladium acetate Pd(OAc)2 and 0.2 mmol YPhos in a Schlenk vessel. 1 ml of dry THF (tetrahydrofuran) was added, the mixture was stirred for 30 min, and 0.1 ml of the thus obtained solution was added to the reaction mixture, and all was stirred at 140° C. for 3 hours. Yields were determined by F-NMR analysis with α,α,α-trifluorotoluene as internal standard.
- YPhos:
- Funding
- For the project on which this application is based, grants of the European Research Council (ERC) were provided within the scope of the programme of the European Union for Research and Innovation “Horizon 2020” (Grant Agreement No. 677749).
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