Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
  • A61K31/05—Phenols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K31/00—Medicinal preparations containing organic active ingredients
  • A61K31/33—Heterocyclic compounds
  • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
  • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
  • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
  • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
  • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
  • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/0012—Galenical forms characterised by the site of application
  • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Definitions

• NSAIDs non-steroidal anti-inflammatory drugs
• acetaminophen acetaminophen
• antidepressants anti-seizure medicines
• steroids opioids
• analgesics and antihistamines.
• antihistamines drugs that have been used to treat pain.
• NSAIDs non-steroidal anti-inflammatory drugs
• these drugs are not always safe, effective, or even appropriate.
• This unmet need is particularly true for patients suffering from neuropathic pain. For example, up to 50% of patients with neuropathic pain do not respond to any treatment at all.
• Cannabinoids are a class of compounds that act on the cannabinoid receptors in cells.
• Cannabinoids can be endogenous (i.e., endocannabinoids; present endogenously in human or animal tissues), synthetic, or derived from plants (i.e., phytocannabinoids).
• a well-known source of phytocannabinoids is the genus of plants known as Cannabis or more colloquially referred to as marijuana. At least 104 phytocannabinoids have been isolated from marijuana to date, and many of these compounds have widely variable biological activities and properties.
• Cannabinoids have been reported to provide various therapeutic benefits for humans, including effects that are anti-psychotic, analgesic, anti-inflammatory, anti-spasmodic, anti-convulsant, anti-emetic, antioxidant, neuroprotective, and immunomodulatory.
• certain cannabinoids have been investigated for their benefit in treating symptoms of pain; however, there are significant challenges and issues relating to their safe, effective, and federally acceptable use such as, for example, a wide range of side effects, a complex mechanisms of action, purity, consistency, quality control, product sourcing, and cost.
• the invention in one aspect, relates to topical cannabinoid compositions and methods of making and using same in, for example, the treatment of injuries involving the muscles, joints, cartilage, and/or tendons.
• compositions comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil; and (c) a wax.
• compositions comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil selected from MCT oil and coconut oil; and (c) a wax.
• kits comprising a disclosed composition, and one or more of: (a) an agent known for the treatment of pain; (b) instructions for treating an injury selected from a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof, wherein the composition and the agent are not co-formulated.
• Ranges can be expressed herein as from “about” one particular value, and/or to “about” another particular value. When such a range is expressed, another aspect includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent “about,” it will be understood that the particular value forms another aspect. It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint. It is also understood that there are a number of values disclosed herein, and that each value is also herein disclosed as “about” that particular value in addition to the value itself. For example, if the value “10” is disclosed, then “about 10” is also disclosed. It is also understood that each unit between two particular units are also disclosed. For example, if 10 and 15 are disclosed, then 11, 12, 13, and 14 are also disclosed.
• the terms “about” and “at or about” mean that the amount or value in question can be the value designated some other value approximately or about the same. It is generally understood, as used herein, that it is the nominal value indicated ⁇ 10% variation unless otherwise indicated or inferred. The term is intended to convey that similar values promote equivalent results or effects recited in the claims. That is, it is understood that amounts, sizes, formulations, parameters, and other quantities and characteristics are not and need not be exact, but can be approximate and/or larger or smaller, as desired, reflecting tolerances, conversion factors, rounding off, measurement error and the like, and other factors known to those of skill in the art.
• an amount, size, formulation, parameter or other quantity or characteristic is “about” or “approximate” whether or not expressly stated to be such. It is understood that where “about” is used before a quantitative value, the parameter also includes the specific quantitative value itself, unless specifically stated otherwise.
• the term “by weight,” when used in conjunction with a component, unless specially stated to the contrary is based on the total weight of the formulation or composition in which the component is included. For example, if a particular element or component in a composition or article is said to have 8% by weight, it is understood that this percentage is in relation to a total compositional percentage of 100%.
• the term “pharmaceutically acceptable topical carrier” refers to a material, composition, diluent, or vehicle that is suitable for application to skin or mucosal surfaces, without undue toxicity, irritation, or allergic response.
• pharmaceutically acceptable topical carriers include, but are not limited to, creams, lotions, ointments, pastes, jellies, and gels.
• the pharmaceutically acceptable topical carrier is known as being useful in cosmetic agents and toiletry agents such as, for example, sunscreen and other sun products, anti-aging agents, moisturizing agents, and baby creams.
• the term “subject” can be a vertebrate, such as a mammal, a fish, a bird, a reptile, or an amphibian.
• the subject of the herein disclosed methods can be a human, non-human primate, horse, pig, rabbit, dog, sheep, goat, cow, cat, guinea pig or rodent.
• the term does not denote a particular age or sex. Thus, adult and newborn subjects, as well as fetuses, whether male or female, are intended to be covered.
• the subject is a mammal.
• a patient refers to a subject afflicted with an ailment, disease, or disorder.
• patient includes human and veterinary subjects.
• treatment refers to the medical management of a patient with the intent to cure, ameliorate, stabilize, or prevent an ailment, disease, pathological condition, disorder, or injury.
• This term includes active treatment, that is, treatment directed specifically toward the improvement of a skin ailment, disease, pathological condition, disorder, or injury, and also includes causal treatment, that is, treatment directed toward removal of the cause of the associated skin ailment, disease, pathological condition, disorder, or injury.
• this term includes palliative treatment, that is, treatment designed for the relief of symptoms rather than the curing of the skin ailment, disease, pathological condition, disorder, or injury; preventative treatment, that is, treatment directed to minimizing or partially or completely inhibiting the development of the associated skin ailment, disease, pathological condition, disorder, or injury; and supportive treatment, that is, treatment employed to supplement another specific therapy directed toward the improvement of the associated skin ailment, disease, pathological condition, disorder, or injury.
• palliative treatment that is, treatment designed for the relief of symptoms rather than the curing of the skin ailment, disease, pathological condition, disorder, or injury
• preventative treatment that is, treatment directed to minimizing or partially or completely inhibiting the development of the associated skin ailment, disease, pathological condition, disorder, or injury
• supportive treatment that is, treatment employed to supplement another specific therapy directed toward the improvement of the associated skin ailment, disease, pathological condition, disorder, or injury.
• the term covers any treatment of a subject, including a mammal (e.g., a human), and includes: (i) preventing the injury from occurring in a subject that can be predisposed to the injury but has not yet been diagnosed as having it; (ii) inhibiting the injury, i.e., arresting its development or exacerbation thereof; or (iii) relieving the injury, i.e., promoting healing of the injury.
• the subject is a mammal such as a primate, and, in a further aspect, the subject is a human.
• subject also includes domesticated animals (e.g., cats, dogs, etc.), livestock (e.g., cattle, horses, pigs, sheep, goats, etc.), and laboratory animals (e.g., mouse, rabbit, rat, guinea pig, fruit fly, etc.).
• domesticated animals e.g., cats, dogs, etc.
• livestock e.g., cattle, horses, pigs, sheep, goats, etc.
• laboratory animals e.g., mouse, rabbit, rat, guinea pig, fruit fly, etc.
• prevent refers to precluding, averting, obviating, forestalling, stopping, or hindering something from happening, especially by advance action. It is understood that where reduce, inhibit or prevent are used herein, unless specifically indicated otherwise, the use of the other two words is also expressly disclosed.
• diagnosis means having been subjected to a physical examination by a person of skill, for example, a physician, and found to have a condition that can be diagnosed or treated by the compositions or methods disclosed herein.
• administering refers to any method of providing a pharmaceutical preparation to a subject. Such methods are well known to those skilled in the art and include, but are not limited to, oral administration, transdermal administration, administration by inhalation, nasal administration, topical administration, intravaginal administration, ophthalmic administration, intraaural administration, intracerebral administration, rectal administration, sublingual administration, buccal administration, and parenteral administration, including injectable such as intravenous administration, intra-arterial administration, intramuscular administration, and subcutaneous administration. Administration can be continuous or intermittent.
• a preparation can be administered therapeutically; that is, administered to treat an existing disease or condition.
• a preparation can be administered prophylactically; that is, administered for prevention of a disease or condition.
• Topical as used with respect to a composition means a composition that is applied to the skin or mucosal membrane of a subject such as, for example, a human.
• a topical composition is intended to have an effect at the site of application, i.e., in the tissue beneath the site of application, and does not result in significant drug concentrations in the blood and other tissues.
• a topical composition can be transdermal, i.e., absorbed through the skin/mucosal membrane and/or having a systemic effect in areas of the body away from the site of application.
• a topical composition can be non-transdermal, i.e., having a local or non-systemic effect.
• the terms “effective amount” and “amount effective” refer to an amount that is sufficient to achieve the desired result or to have an effect on an undesired condition.
• a “therapeutically effective amount” refers to an amount that is sufficient to achieve the desired therapeutic result or to have an effect on undesired symptoms, but is generally insufficient to cause adverse side effects.
• the specific therapeutically effective dose level for any particular patient will depend upon a variety of factors including the disorder being treated and the severity of the disorder; the specific composition employed; the age, body weight, general health, sex and diet of the patient; the time of administration; the route of administration; the rate of excretion of the specific compound employed; the duration of the treatment; drugs used in combination or coincidental with the specific compound employed and like factors well known in the medical arts. For example, it is well within the skill of the art to start doses of a compound at levels lower than those required to achieve the desired therapeutic effect and to gradually increase the dosage until the desired effect is achieved. If desired, the effective daily dose can be divided into multiple doses for purposes of administration.
• compositions can contain such amounts or submultiples thereof to make up the daily dose.
• the dosage can be adjusted by the individual physician in the event of any contraindications. Dosage can vary, and can be administered in one or more dose administrations daily, for one or several days. Guidance can be found in the literature for appropriate dosages for given classes of pharmaceutical products.
• a preparation can be administered in a “prophylactically effective amount”; that is, an amount effective for prevention of a disease or condition.
• dosage form means a pharmacologically active material in a medium, carrier, vehicle, or device suitable for administration to a subject.
• a dosage forms can comprise inventive a disclosed composition or a product of a disclosed method of making, in combination with a pharmaceutically acceptable excipient, such as a preservative, buffer, saline, or phosphate buffered saline. Dosage forms can be made using conventional pharmaceutical manufacturing and compounding techniques.
• Dosage forms can comprise inorganic or organic buffers (e.g., sodium or potassium salts of phosphate, carbonate, acetate, or citrate) and pH adjustment agents (e.g., hydrochloric acid, sodium or potassium hydroxide, salts of citrate or acetate, amino acids and their salts) antioxidants (e.g., ascorbic acid, alpha-tocopherol), surfactants (e.g., polysorbate 20, polysorbate 80, polyoxyethylene 9-10 nonyl phenol, sodium desoxycholate), solution and/or cryo/lyo stabilizers (e.g., sucrose, lactose, mannitol, trehalose), osmotic adjustment agents (e.g., salts or sugars), antibacterial agents (e.g., benzoic acid, phenol, gentamicin), antifoaming agents (e.g., polydimethylsilozone), preservatives (e.g., thimerosal, 2-phen
• kit means a collection of at least two components constituting the kit. Together, the components constitute a functional unit for a given purpose. Individual member components may be physically packaged together or separately. For example, a kit comprising an instruction for using the kit may or may not physically include the instruction with other individual member components. Instead, the instruction can be supplied as a separate member component, either in a paper form or an electronic form which may be supplied on computer readable memory device or downloaded from an internet website, or as recorded presentation.
• instruction(s) means documents describing relevant materials or methodologies pertaining to a kit. These materials may include any combination of the following: background information, list of components and their availability information (purchase information, etc.), brief or detailed protocols for using the kit, trouble-shooting, references, technical support, and any other related documents. Instructions can be supplied with the kit or as a separate member component, either as a paper form or an electronic form which may be supplied on computer readable memory device or downloaded from an internet website, or as recorded presentation. Instructions can comprise one or multiple documents, and are meant to include future updates.
• therapeutic agent include any synthetic or naturally occurring biologically active compound or composition of matter which, when administered to an organism (human or nonhuman animal), induces a desired pharmacologic, immunogenic, and/or physiologic effect by local and/or systemic action.
• the term therefore encompasses those compounds or chemicals traditionally regarded as drugs, vaccines, and biopharmaceuticals including molecules such as proteins, peptides, hormones, nucleic acids, gene constructs and the like.
• therapeutic agents include, without limitation, medicaments; vitamins; mineral supplements; substances used for the treatment, prevention, diagnosis, cure or mitigation of a disease or illness; substances that affect the structure or function of the body, or pro-drugs, which become biologically active or more active after they have been placed in a physiological environment.
• the term “therapeutic agent” includes compounds or compositions for use in all of the major therapeutic areas including, but not limited to, adjuvants; anti-infectives such as antibiotics and antiviral agents; anti-HIV agents such as entry inhibitors, fusion inhibitors, non-nucleoside reverse transcriptase inhibitors (NNRTIs), nucleoside reverse transcriptase inhibitors (NRTIs), nucleotide reverse transcriptase inhibitors, NCP7 inhibitors, protease inhibitors, and integrase inhibitors; analgesics and analgesic combinations, anorexics, anti-inflammatory agents, anti-epileptics, local and general anesthetics, hypnotics, sedatives, antipsychotic agents, neuroleptic agents, antidepressants, anxiolytics, antagonists, neuron blocking agents, anticholinergic and cholinomimetic agents, antimuscarinic and muscarinic agents, antiadrenergics, antiar
• the agent may be a biologically active agent used in medical, including veterinary, applications and in agriculture, such as with plants, as well as other areas.
• therapeutic agent also includes without limitation, medicaments; vitamins; mineral supplements; substances used for the treatment, prevention, diagnosis, cure or mitigation of disease or illness; or substances which affect the structure or function of the body; or pro-drugs, which become biologically active or more active after they have been placed in a predetermined physiological environment.
• pharmaceutically acceptable describes a material that is not biologically or otherwise undesirable, i.e., without causing an unacceptable level of undesirable biological effects or interacting in a deleterious manner.
• aqueous and nonaqueous carriers include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol and the like), carboxymethylcellulose and suitable mixtures thereof, vegetable oils (such as olive oil) and injectable organic esters such as ethyl oleate.
• Proper fluidity can be maintained, for example, by the use of coating materials such as lecithin, by the maintenance of the required particle size in the case of dispersions and by the use of surfactants.
• These compositions can also contain adjuvants such as preservatives, wetting agents, emulsifying agents and dispersing agents.
• Prevention of the action of microorganisms can be ensured by the inclusion of various antibacterial and antifungal agents such as paraben, chlorobutanol, phenol, sorbic acid and the like. It can also be desirable to include isotonic agents such as sugars, sodium chloride and the like.
• Prolonged absorption of the injectable pharmaceutical form can be brought about by the inclusion of agents, such as aluminum monostearate and gelatin, which delay absorption.
• Injectable depot forms are made by forming microencapsule matrices of the drug in biodegradable polymers such as polylactide-polyglycolide, poly(orthoesters) and poly(anhydrides). Depending upon the ratio of drug to polymer and the nature of the particular polymer employed, the rate of drug release can be controlled. Depot injectable formulations are also prepared by entrapping the drug in liposomes or microemulsions which are compatible with body tissues.
• the injectable formulations can be sterilized, for example, by filtration through a bacterial-retaining filter or by incorporating sterilizing agents in the form of sterile solid compositions which can be dissolved or dispersed in sterile water or other sterile injectable media just prior to use.
• Suitable inert carriers can include sugars such as lactose. Desirably, at least 95% by weight of the particles of the active ingredient have an effective particle size in the range of 0.01 to 10 micrometers.
• references in the specification and concluding claims to parts by weight of a particular element or component in a composition or article denotes the weight relationship between the element or component and any other elements or components in the composition or article for which a part by weight is expressed.
• X and Y are present at a weight ratio of 2:5, and are present in such ratio regardless of whether additional components are contained in the composition.
• the term “essentially,” in, for example, the context “essentially absent” refers to a composition having less than about 10% by weight, e.g., less than about 5%, less than about 1%, less than about 0.5%, less than about 0.1%, less than about 0.05%, or less than about 0.01% by weight of the stated material, based on the total weight of the composition.
• the term “substantially,” when used in reference to a composition, refers to at least about 60% by weight, e.g., at least about 65%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, at least about 95%, at least about 96%, at least about 97%, at least about 98%, at least about 99%, or about 100% by weight, based on the total weight of the composition, of a specified feature, component, or a combination of the components. It is further understood that if the composition comprises more than one component, the two or more components can be present in any ratio predetermined by one of ordinary skill in the art.
• derivative refers to a compound having a structure derived from the structure of a parent compound (e.g., a compound disclosed herein) and whose structure is sufficiently similar to those disclosed herein and based upon that similarity, would be expected by one skilled in the art to exhibit the same or similar activities and utilities as the claimed compounds, or to induce, as a precursor, the same or similar activities and utilities as the claimed compounds.
• exemplary derivatives include salts, esters, and amides, salts of esters or amides, and N-oxides of a parent compound.
• compositions comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil; and (c) a wax.
• compositions comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil selected from MCT oil and coconut oil; and (c) a wax.
• the composition consists essentially of the cannabinoid, the oil, and the wax.
• composition is topical.
• compositions of the present invention can be in any form suitable for topical use such as, for example, an aerosol, cream, ointment, lotion, dusting powder, paste, spray, lotion, gel, jelly, and the like.
• aerosol a form suitable for topical use
• lotion a form suitable for topical use
• dusting powder a powder that can be used to prepare a powder that can be used to prepare a powder that can be used to prepare a powder.
• the composition comprises an oil.
• oils include, but are not limited to, olive oil, almond oil, apricot kernel oil, avocado oil, borage seed oil, camellia seed oil (tea oil), cranberry seed oil, evening primrose oil, grapeseed oil, hazelnut oil, hemp seed oil, jojoba, kukui nut oil, macademia nut oil, meadowfoam oil, peanut oil, pecan oil, pomegranate seed oil, rose hip oil, seabuckthorn berry oil, sesame seed oil, coconut oil, sunflower oil, watermelon seed oil, and MCT oil, or mixtures thereof.
• the amount of oil present can be dependent upon the formulation of the composition.
• the oil is present in an amount of from about 20 wt % to about 30 wt %, 25 wt % to about 30 wt %, or 20 wt % to about 25 wt %.
• the oil is present in an amount of from about 50 wt % to about 98 wt %, 60 wt % to about 98 wt %, 70 wt % to about 98 wt %, 80 wt % to about 98 wt %, 90 wt % to about 98 wt %, 50 wt % to about 90 wt %, 50 wt % to about 80 wt %, 50 wt % to about 70 wt %, or 50 wt% to about 60 wt %.
• the oil is naturally occurring. In a still further aspect, the oil is non-naturally occurring (e.g., MCT oil).
• the composition comprises an oil selected from MCT oil and coconut oil.
• the oil is MCT oil.
• the oil is coconut oil.
• the composition comprises a cannabinoid.
• Cannabinoids are a class of diverse chemical compounds that act on cannabinoid receptors on cells that repress neurotransmitter release in the brain.
• Cannabinoid receptors are of a class of cell membrane receptors under the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains.
• the CB1 receptor is expressed mainly in the brain (central nervous system), but also in the lungs, liver and kidneys.
• the CB2 receptor is expressed mainly in the immune system and in hematopoietic cells.
• the classical cannabinoids are derived from their respective 2-carboxylic acids (2-COOH) by decarboxylation, catalyzed by heat, light, or alkaline conditions.
• Phytocannabinoids include but not limited to: tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), cannabidiol (CBD), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), cannabicyclol (CBL), cannabivarin (CBV), tetrahydrocannabivarin (THCV), cannabidivarin (CBDV), cannabichromevarin (CBCV), cannabigerovarin (CBGV) and cannabigerol monomethyl ether (CBGM).
• THC tetrahydrocannabinol
• THCA tetra
• the cannabinoid is THC, CBD, THCA, CBDA, CBN, CBG, CBC, or CBGM, or a mixture thereof.
• the cannabinoid is THC or CBD, or a mixture thereof.
• the cannabinoid is THC.
• the cannabinoid is CBD.
• the cannabinoid is present in an amount of from about 10 wt % to about 14 wt %.
• the cannabinoid is present in an amount of from about 10 wt % to about 13 wt %, about 10 wt % to about 12 wt %, about 10 wt % to about 11 wt %, about 11 wt % to about 14 wt %, about 12 wt % to about 14 wt %, about 13 wt % to about 14 wt %, or about 11 wt % to about 13 wt %.
• composition further comprises vitamin E.
• the composition comprises vitamin E in an amount of from about 0.25 wt % to about 4 wt %, about 0.25 wt % to about 3 wt %, about 0.25 wt % to about 2 wt %, about 0.25 wt % to about 1 wt %, about 0.25 wt % to about 0.75 wt %, about 0.75 wt % to about 4 wt %, about 1 wt % to about 4 wt %, about 2 wt % to about 4 wt %, or about 3 wt % to about 4 wt %.
• the composition further comprises one or more of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises two or more of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises three or more of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises each of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises cocoa butter.
• the composition further comprises shea butter.
• the composition further comprises jojoba oil.
• vitamin B 12 is essentially absent from the composition. In a further aspect, vitamin B 12 is present in the composition in an amount less than less than about 10 wt %, less than about 5 wt %, less than about 1 wt %, less than about 0.5 wt %, less than about 0.1 wt %, less than about 0.05 wt% , or less than about 0.01 wt %.
• a nonsteroidal anti-inflammatory drug is essentially absent from the composition.
• a NSAID is present in the composition in an amount less than less than about 10 wt %, less than about 5 wt %, less than about 1 wt %, less than about 0.5 wt %, less than about 0.1 wt %, less than about 0.05 wt %, or less than about 0.01 wt %.
• the composition further comprises an additive.
• additives include, but are not limited to, diluents, buffers, binders, surface-active agents, lubricants, humectants, pH adjusting agents, preservatives (including anti-oxidants), emulsifiers, occlusive agents, opacifiers, antioxidants, colorants, flavoring agents, gelling agents, thickening agents, stabilizers, and surfactants, among others.
• the additive is present in an amount of from about 0.01 wt % to about 10 wt % of the composition. In a still further aspect, the additive is present in an amount of from about 0.01 wt % to about 8 wt % of the composition. In yet a further aspect, the additive is present in an amount of from about 0.01 wt % to about 6 wt % of the composition. In an even further aspect, the additive is present in an amount of from about 0.01 wt % to about 4 wt % of the composition. In a still further aspect, the additive is present in an amount of from about 0.01 wt % to about 2 wt % of the composition.
• the additive is present in an amount of from about 0.01 wt % to about 1 wt % of the composition. In an even further aspect, the additive is present in an amount of from about 0.1 wt % to about 10 wt % of the composition. In a still further aspect, the additive is present in an amount of from about 1 wt % to about 10 wt % of the composition. In yet a further aspect, the additive is present in an amount of from about 2 wt % to about 10 wt % of the composition. In an even further aspect, the additive is present in an amount of from about 4 wt % to about 10 wt % of the composition.
• the additive is present in an amount of from about 6 wt % to about 10 wt % of the composition. In yet a further aspect, the additive is present in an amount of from about 8 wt % to about 10 wt % of the composition.
• compositions can be employed in the disclosed methods of using.
• cannabinoids produce analgesia by activating specific receptors throughout the body, in particular cannabinoid receptor 1 (CB1), which are found predominantly in the central nervous system (CNS), and cannabinoid receptor 2 (CB2), found predominantly in cells involved with immune function.
• CBD1 cannabinoid receptor 1
• CB2 cannabinoid receptor 2
• GPCR cannabinoid G protein-coupled receptor
• N-arachidonoyl glycine N-arachidonoyl glycine
• TRP transient receptor potential
• TRPV1 and CB1 or CB2 are co-localized at peripheral and/or central neurons (sensory neurons, dorsal root ganglia, spinal cord, brain neurons), which results in their intracellular crosstalk in situations where these receptors are involved simultaneously.
• peripheral and/or central neurons sensor neurons, dorsal root ganglia, spinal cord, brain neurons
• TRPV1 receptors are co-localized at peripheral and/or central neurons (sensory neurons, dorsal root ganglia, spinal cord, brain neurons), which results in their intracellular crosstalk in situations where these receptors are involved simultaneously.
• New data demonstrate a variety of interactions between cannabinoid, opioid, and TRPV1 receptors in pain modulation. Without wishing to be bound by theory, these receptors represent potentially attractive targets for the therapeutic use of cannabinoids in the treatment of pain.
• THC The main psychoactive compound
• the THC content varies from about 5% in marijuana to about 80% in hashish oil.
• THC is an analog to the endogenous cannabinoid, anandamide (ananda is the Sanskrit word for bliss; arachidonoylethanolamide, AEA). It is responsible for most of the pharmacological actions of cannabis, including the psychoactive, analgesic, anti-inflammatory, anti-oxidant, antipruritic, bronchodilatory, anti-spasmodic, and muscle-relaxant activities.
• THC acts as a partial agonist at cannabinoid receptors (CB1 and CB2).
• CB1 and CB2 cannabinoid receptors
• a very high binding affinity of THC with the CB1 receptor appears to mediate its psychoactive properties (changes in mood or consciousness), memory processing, motor control, etc. It has been reported that a number of side effects of THC, including anxiety, impaired memory and immunosuppression, can be reversed by other constituents of the cannabis plant (cannabinoids, terpenoids, and flavonoids).
• CBD cannabidiol
• CBD also regulates the perception of pain by affecting the activity of a significant number of other targets, including non-cannabinoid GPCRs (e.g., 5-HT1A), ion channels (TRPV1, TRPA1 and TPRM8, GlyR), PPARs, while also inhibiting uptake of AEA and weakly inhibiting its hydrolysis by the enzyme fatty acid amide hydrolase (FAAH).
• cannabidiol can act synergistically with THC and contribute to the analgesic effect of medicinal-based cannabis extract.
• CBD displays an entourage effect (the mechanism by which non-psychoactive compounds present in cannabis modulate the overall effects of the plant), and is capable of improving tolerability and perhaps also the safety of THC by reducing the likelihood of psychoactive effects and antagonizing several other adverse effects of THC (sedation, tachycardia, and anxiety).
• the differences in concentration of THC and CBD in the plant reflect the differences in the effects of different cannabis strains.
• phytocannabinoids that can contribute to the overall analgesic effects of medical cannabis are cannabichromene (CBC), cannabigerol (CBG), tetrahydrocannabivarin (THCV), and many others.
• CBD cannabichromene
• CBD cannabigerol
• THCV tetrahydrocannabivarin
• the endocannabinoid system regulate many functions in the body, including learning and memory, mood and anxiety, drug addiction, feeding behavior, perception, modulation of pain and cardiovascular functions.
• the endocannabinoid system consists of cannabinoid receptors, endogenous cannabinoids (endocannabinoids), transport proteins and enzymes that synthesize or degrade the endocannabinoids.
• Cannabinoid CB1 and CB2 receptors are 7-transmembrane G-protein coupled receptors (GPCRs). They play an important role in peripheral, spinal, and supraspinal nociception, including ascendant and descendent pain pathways.
• GPCRs G-protein coupled receptors
• the signal transduction pathway of CB1 and CB2 involves inhibition of adenylyl cyclase, decreased cAMP formation, as well as an increase in the activity of mitogen-activated protein kinases (MAPK).
• MAPK mitogen-activated protein kinases
• CB1 receptor is distributed throughout the nervous system. It mediates psychoactivity, pain regulation, memory processing, and motor control.
• CB1 is a presynaptic heteroreceptor that modulates neurotransmitter and neuropeptide release and inhibits synaptic transmission. Activation of CB1 results in the activation of inwardly rectifying potassium channels, which decrease presynaptic neuron firing, and in the inhibition of voltage-sensitive calcium channels that decrease neurotransmitter release.
• the CB1 receptor is strategically located in regions of the peripheral and CNS where pain signaling is intricately controlled, including the peripheral and central terminals of primary afferent neurons, the dorsal root ganglion (DRG), the dorsal horn of the spinal cord, the periaqueductal gray matter, the ventral posterolateral thalamus and cortical regions associated with central pain processing, including the anterior cingulate cortex, amygdala and prefrontal cortex.
• the principal endogenous ligand for the CB1 receptor is AEA.
• CB1 receptors are observed more often on the gamma-aminobutyric acid (GABA) inhibitory interneurons in the dorsal horn of the spinal cord, and weakly expressed in most excitatory neurons.
• CB1 receptors are also present in multiple immune cells such as macrophages, mast cells and epidermal keratinocytes.
• the CB2 receptor is found predominantly at the periphery (in tissues and cells of the immune system, hematopoietic cells, bone, liver, peripheral nerve terminals, keratinocytes), but also in brain microglia.
• the receptors are responsible for the inhibition of cytokine/chemokine release and neutrophil and macrophage migration and they contribute to slowing down of chronic inflammatory processes and modulate chronic pain.
• Both CB2 and CB1 receptors on mast cells participate in the anti-inflammatory mechanism of action of cannabinoids.
• activation of CB2 receptors on keratinocytes stimulates the release of ⁇ -endorphin, which acts at opioid receptors on peripheral sensory neurons to inhibit nociception.
• CB2 receptors are present at low levels in the brain, the spinal cord and DRG, but may be upregulated in microglia where they modulate neuroimmune interaction in inflammation and after peripheral nerve damage.
• CB2 receptor activation inhibits adenylyl cyclase activity and stimulates MAPK activity, but the effect on calcium or potassium conductance is controversial. Stimulation of CB2 receptors does not produce cannabis-like effects on the psyche and circulation.
• the principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG).
• Endocannabinoids are arachidonic acid derivatives. AEA and 2-AG are synthesized separately, they have local (autocrine and paracrine) effects and are rapidly removed by hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. Besides AEA, FAAH inhibition significantly elevates the levels of other fatty-acid amides such as oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the CNS and peripheral tissues. Endocannabinoids, similarly to THC, appear to activate cannabinoid receptors. AEA and 2-AG are a partial and full agonist of CB receptors, respectively. They work as a part of a negative feedback loop that regulates neurotransmitter and neuropeptide release and thereby modulate various CNS functions, including pain processing.
• FAAH fatty acid amide hydrolase
• MAGL monoacylglycerol lipase
• the AEA is a full agonist at TRPV1 (AEA referred to as an ‘endovanilloid’) that activates TRPV1 which results in desensitization.
• AEA also activates GR55, directly inhibits 5-HT3A receptors, potentiates the function of glycine receptors, inhibits T-type voltage-gated calcium channels, and activates PPARs.
• Endocannabinoids which are produced in neural and non-neural cells in the physiological response to tissue injury or excessive nociceptive signaling, suppress inflammation, sensitization and pain. Inhibitors of FAAH lead to elevated AEA levels and are intended for therapeutic use.
• N-acylethanolamines such as PEA and OEA do not belong to endocannabinoids as they do not bind to cannabinoid receptors; they exhibit anti-inflammatory action via PPARs, and also inhibit pain through TRPV1 receptors. They are also of interest to the field of cannabinoid pain research as they elevate levels of AEA through substrate competition at FAAH.
• AEA cyclooxygenase-2
• Dronabinol is a generic name for the oral form of synthetic THC (Marinol®). It is approved for the treatment of chemotherapy-associated nausea and vomiting, and anorexia associated with human immunodeficiency virus infection.
• Nabilone a generic name for the orally administered synthetic structural analog of THC (Cesamet®), is approved for the treatment of chemotherapy-associated nausea and vomiting.
• Their medical use is mostly limited by their psychoactive side effects, as well as their limited bioavailability).
• Cannabis delivered by way of inhalation (smoked or inhaled through vaporization), orally or oromucosally, produces a host of biological effects.
• clinical trials conducted on cannabis are limited, and no drug agency has approved the use of cannabis as a treatment for any medical condition. Although there is no formal approval, cannabis is widely used for the treatment of pain. It is authorized by physicians where medical marijuana is legal.
• an oromucosal spray is approved as an adjuvant treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS) who have not responded well to other therapy and who have demonstrated a significant improvement during an initial trial of Sativex® therapy.
• Sativex® is approved in Canada (under the Notice of Compliance with Conditions) as an adjuvant treatment for symptomatic relief of neuropathic pain in adults with MS, and as an adjuvant analgesic in adult patients with advanced cancer who suffer from moderate to severe pain that is resistant to strong opioids.
• nabiximols is also approved in the United Kingdom and some European countries (e.g., Spain).
• the United States Food and Drug Administration (FDA) has not yet approved nabiximols as a treatment for any medical condition.
• FDA Investigational New Drug Application
• nabiximols also contains other cannabinoids, terpenoids, and flavonoids.
• the method comprises the step of combining: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil; and (c) a wax, thereby providing the disclosed composition.
• the method comprises the step of combining: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil selected from MCT oil and coconut oil; and (c) a wax, thereby providing the disclosed composition.
• the composition comprises an oil.
• oils include, but are not limited to, olive oil, almond oil, apricot kernel oil, avocado oil, borage seed oil, camellia seed oil (tea oil), cranberry seed oil, evening primrose oil, grapeseed oil, hazelnut oil, hemp seed oil, jojoba, kukui nut oil, macademia nut oil, meadowfoam oil, peanut oil, pecan oil, pomegranate seed oil, rose hip oil, seabuckthorn berry oil, sesame seed oil, coconut oil, sunflower oil, watermelon seed oil, and MCT oil, or mixtures thereof.
• the amount of oil present can be dependent upon the formulation of the composition.
• the oil is present in an amount of from about 20 wt % to about 30 wt %, 25 wt % to about 30 wt %, or 20 wt % to about 25 wt %.
• the oil is present in an amount of from about 50 wt % to about 98 wt %, 60 wt % to about 98 wt %, 70 wt % to about 98 wt %, 80 wt % to about 98 wt %, 90 wt % to about 98 wt %, 50 wt % to about 90 wt %, 50 wt % to about 80 wt %, 50 wt % to about 70 wt %, or 50 wt % to about 60 wt %.
• the composition comprises an oil selected from MCT oil and coconut oil.
• the oil is MCT oil.
• the oil is coconut oil.
• the composition comprises a cannabinoid.
• the cannabinoid is THC, CBD, THCA, CBDA, CBN, CBG, CBC, or CBGM, or a mixture thereof.
• the cannabinoid is THC or CBD, or a mixture thereof.
• the cannabinoid is THC.
• the cannabinoid is CBD.
• the cannabinoid is present in an amount of from about 10 wt % to about 14 wt %.
• the cannabinoid is present in an amount of from about 10 wt % to about 13 wt %, about 10 wt % to about 12 wt %, about 10 wt % to about 11 wt %, about 11 wt % to about 14 wt %, about 12 wt % to about 14 wt %, about 13 wt % to about 14 wt %, or about 11 wt % to about 13 wt %.
• composition further comprises vitamin E.
• the composition comprises vitamin E in an amount of from about 0.25 wt % to about 4 wt %, about 0.25 wt % to about 3 wt %, about 0.25 wt % to about 2 wt %, about 0.25 wt % to about 1 wt %, about 0.25 wt % to about 0.75 wt %, about 0.75 wt % to about 4 wt %, about 1 wt % to about 4 wt %, about 2 wt % to about 4 wt %, or about 3 wt % to about 4 wt %.
• the composition further comprises one or more of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises two or more of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises three or more of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises each of cocoa butter, shea butter, an essential oil, and a jojoba oil.
• the composition further comprises cocoa butter.
• the composition further comprises shea butter.
• the composition further comprises jojoba oil.
• vitamin B12 is essentially absent from the composition. In a further aspect, vitamin B12 is present in the composition in an amount less than less than about 10 wt %, less than about 5 wt %, less than about 1 wt %, less than about 0.5 wt %, less than about 0.1 wt %, less than about 0.05 wt %, or less than about 0.01 wt %.
• a nonsteroidal anti-inflammatory drug is essentially absent from the composition.
• a NSAID is present in the composition in an amount less than less than about 10 wt %, less than about 5 wt %, less than about 1 wt %, less than about 0.5 wt %, less than about 0.1 wt %, less than about 0.05 wt %, or less than about 0.01 wt %.
• the composition further comprises an additive.
• additives include, but are not limited to, diluents, buffers, binders, surface-active agents, lubricants, humectants, pH adjusting agents, preservatives (including anti-oxidants), emulsifiers, occlusive agents, opacifiers, antioxidants, colorants, flavoring agents, gelling agents, thickening agents, stabilizers, and surfactants, among others.
• the additive is present in an amount of from about 0.01 wt % to about 10 wt % of the composition. In a still further aspect, the additive is present in an amount of from about 0.01 wt % to about 8 wt % of the composition. In yet a further aspect, the additive is present in an amount of from about 0.01 wt % to about 6 wt % of the composition. In an even further aspect, the additive is present in an amount of from about 0.01 wt % to about 4 wt % of the composition. In a still further aspect, the additive is present in an amount of from about 0.01 wt % to about 2 wt % of the composition.
• the additive is present in an amount of from about 0.01 wt % to about 1 wt % of the composition. In an even further aspect, the additive is present in an amount of from about 0.1 wt % to about 10 wt % of the composition. In a still further aspect, the additive is present in an amount of from about 1 wt % to about 10 wt % of the composition. In yet a further aspect, the additive is present in an amount of from about 2 wt % to about 10 wt % of the composition. In an even further aspect, the additive is present in an amount of from about 4 wt % to about 10 wt % of the composition.
• the additive is present in an amount of from about 6 wt % to about 10 wt % of the composition. In yet a further aspect, the additive is present in an amount of from about 8 wt % to about 10 wt % of the composition.
• compositions are useful in treating or ameliorating an injury such as, for example, a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof.
• the compounds or compositions can be administered to the subject via topical administration. Administration can be continuous or intermittent.
• a preparation can be administered therapeutically; that is, administered to treat or ameliorate an existing injury.
• the therapeutically effective amount or dosage of the composition can vary within wide limits. Such a dosage is adjusted to the individual requirements in each particular case including the specific composition(s) being administered and the condition being treated, as well as the patient being treated. In general, Single dose compositions can contain such amounts or submultiples thereof of the composition to make up the daily dose. The dosage can be adjusted by the individual physician in the event of any contraindications. Dosage can vary, and can be administered in one or more dose administrations daily, for one or several days.
• the subject is a mammal.
• the mammal is a human.
• the injury is selected from a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof.
• the compounds disclosed herein are useful for treating or ameliorating injuries such as, for example, muscle injuries, joint injuries, cartilage injuries, and/or tendon injuries.
• a method comprising administering a therapeutically effective amount of a disclosed composition to a subject.
• the method can be a method for treating an injury.
• injuries include, but are not limited to, muscle injuries, joint injuries, cartilage injuries, and/or tendon injuries.
• a composition comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil; and (c) a wax, wherein the injury is a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof
• a composition comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil selected from MCT oil and coconut oil; and (c) a wax, wherein the injury is a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof
• the subject is a mammal. In a further aspect, the subject is a human.
• the method further comprises the step of identifying a subject in need of treatment of the injury.
• the subject has been diagnosed with a need for treatment of the injury prior to the administering step.
• the method further comprises administering at least one agent known for the treatment of pain, wherein the composition and the agent are not co-formulated.
• agents known for the treatment of pain include, but are not limited to, non-steroidal anti-inflammatory drugs (NSAIDs), opioids, counterirritants, salicylates, and capsaicin.
• NSAIDs non-steroidal anti-inflammatory drugs
• opioids opioids
• counterirritants salicylates
• capsaicin capsaicin
• the agent is a NSAID.
• NSADs include, but are not limited to, aspirin, ibuprofen, naproxen, and celecoxib.
• the agent is an opioid.
• opioids include, but are not limited to, oxycodone, hydrocodone, codeine, and morphine.
• the agent is a counterirritant.
• counterirritants include, but are not limited to, menthol, methyl salicylate, and camphor.
• the agent is a salicylate.
• salicylates include, but are not limited to, magnesium salicylate, aspirin, choline salicylate, diflunisal, and salsalate.
• the agent is capsaicin.
• the agent and the composition are administered sequentially. In a still further aspect, the agent and the composition are administered simultaneously.
• the invention relates to the use of a disclosed composition or a product of a disclosed method.
• a use relates to the manufacture of a medicament for the treatment of or alleviation of pain related to an injury on a subject.
• the invention relates to use of at least one disclosed composition.
• the composition used is a product of a disclosed method of making.
• the use relates to a process for preparing a pharmaceutical composition comprising a therapeutically effective amount of a disclosed composition or a product of a disclosed method of making, for use as a medicament.
• the use relates to a process for preparing a pharmaceutical composition
• a pharmaceutical composition comprising a therapeutically effective amount of a disclosed composition or a product of a disclosed method of making, wherein a pharmaceutically acceptable carrier is intimately mixed with a therapeutically effective amount of the composition or the product of a disclosed method of making.
• the use relates to a treatment of or alleviation of pain related to an injury on a subject.
• the use is characterized in that the subject is a human.
• the use is characterized in that the injury is a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof.
• the use relates to the manufacture of a medicament for the treatment of or alleviation of pain related to an injury on a subject.
• the disclosed uses can be employed in connection with the disclosed compositions, products of disclosed methods of making, methods, and kits.
• the invention relates to the use of a disclosed composition or a disclosed product in the manufacture of a medicament for the treatment of or alleviation of pain related to an injury on a mammal.
• the injury is a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof
• the invention relates to a method for the manufacture of a medicament for treating or alleviating pain related to an injury on a subject, the method comprising combining a therapeutically effective amount of a disclosed composition or product of a disclosed method with a pharmaceutically acceptable carrier or diluent.
• the present method includes the administration to an animal, particularly a mammal, and more particularly a human, of a therapeutically effective amount of the composition effective in the treatment of the injury.
• the dose administered to an animal, particularly a human, in the context of the present invention should be sufficient to affect a therapeutic response in the animal over a reasonable time frame.
• dosage will depend upon a variety of factors including the condition of the animal and the body weight of the animal.
• the size of the dose also will be determined by the route, timing, and frequency of administration as well as the existence, nature, and extent of any adverse side effects that might accompany the administration of the composition and the desired physiological effect. It will be appreciated by one of skill in the art that various conditions or injuries, in particular chronic conditions or injuries, may require prolonged treatment involving multiple administrations.
• the invention relates to the manufacture of a medicament comprising combining a disclosed composition or a product of a disclosed method of making, with a pharmaceutically acceptable carrier or diluent.
• kits comprising a disclosed composition.
• kits comprising a composition comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil; and (c) a wax, and one or more of: (d) an agent known for the treatment of pain; and (e) instructions for treating an injury selected from a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof, wherein the composition and the agent are not co-formulated.
• kits comprising a composition comprising: (a) a cannabinoid in an amount of from about 10 wt % to about 14 wt %; (b) an oil selected from MCT oil and coconut oil; and (c) a wax, and one or more of: (d) an agent known for the treatment of pain; and (e) instructions for treating an injury selected from a muscle injury, a joint injury, a cartilage injury, a tendon injury, or a combination thereof, wherein the composition and the agent are not co-formulated.
• the at least one compound and the at least one agent are co-packaged.
• the kit comprises the composition and the agent known for the treatment of pain.
• agents known for the treatment of pain include, but are not limited to, non-steroidal anti-inflammatory drugs (NSAIDs), opioids, counterirritants, salicylates, and capsaicin.
• the agent is a NSAID.
• NSADs include, but are not limited to, aspirin, ibuprofen, naproxen, and celecoxib.
• the agent is an opioid.
• opioids include, but are not limited to, oxycodone, hydrocodone, codeine, and morphine.
• the agent is a counterirritant.
• counterirritants include, but are not limited to, menthol, methyl salicylate, and camphor.
• the agent is a salicylate.
• salicylates include, but are not limited to, magnesium salicylate, aspirin, choline salicylate, diflunisal, and salsalate.
• the agent is capsaicin.
• the agent and the composition are administered sequentially. In a still further aspect, the agent and the composition are administered simultaneously.
• kits can also comprise compounds and/or products co-packaged, co-formulated, and/or co-delivered with other components.
• a drug manufacturer, a drug reseller, a physician, a compounding shop, or a pharmacist can provide a kit comprising a disclosed compound and/or product and another component for delivery to a patient.
• kits can be prepared from the disclosed compounds, products, and pharmaceutical compositions. It is also understood that the disclosed kits can be employed in connection with the disclosed methods of using.

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• 2020
  • 2020-10-28 US US17/082,915 patent/US20210128521A1/en not_active Abandoned
  • 2020-10-28 WO PCT/US2020/057736 patent/WO2021086964A1/en active Application Filing
  • 2020-10-30 AR ARP200103006A patent/AR120350A1/es unknown
  • 2020-10-30 UY UY0001038939A patent/UY38939A/es not_active Application Discontinuation

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