US20200405766A1 - Alkalized organic pharmaceutical or nutraceutical composition - Google Patents
Alkalized organic pharmaceutical or nutraceutical composition Download PDFInfo
- Publication number
- US20200405766A1 US20200405766A1 US17/023,150 US202017023150A US2020405766A1 US 20200405766 A1 US20200405766 A1 US 20200405766A1 US 202017023150 A US202017023150 A US 202017023150A US 2020405766 A1 US2020405766 A1 US 2020405766A1
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- US
- United States
- Prior art keywords
- alkalized
- amino acids
- organic substance
- pharmaceutical
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Definitions
- Unbuffered, acids dissolve calcium from bones and teeth, and facilitate soft-tissue calcification. They corrode cartilage and attack arteries, which (in self-defense) secrete a protective, buffering lipid-calcium complex. The body dilutes the acids by retaining water, but this action, combined with arteriosclerosis, creates hypertension, which can lead to heart and cerebrovascular disease.
- Acid-producing (high-protein, high-salt) diets have been shown to cause urinary stones.
- Salt-induced chloride acidosis has been found to cause irritability, hyperactivity and insomnia.
- Acidosis is a condition in which the body's fluids tend to have a higher acid content than normal. It is a clinical disturbance caused by kidney failure due to decreased pH level characterized by an increase in total body acid. The body has a variety of ways to compensate for mild acidosis, but prolonged acid ingestion can result in weakness, headache, heavy or rapid breathing. Severe acidosis can lead to acidemia, which is a buildup of acids in the blood, resulting in a coma or death.
- Lactic acid is a metabolic acid that is known to hinder athletic performance. Lactic acid is produced by muscle tissue to obtain energy by metabolizing glucose in the absence of oxygen.
- Lactic acid is produced by almost all tissues in the human body and is formed by glycolysis.
- Glycolysis is a chemical process in which glucose is broken down to pyruvic acid. The pyruvic acid, mixed with oxygen is converted to carbon dioxide, water and ATP. ATP provides energy for muscle contraction. Contracting muscles obtain ATP from glycolysis of glucose stored in the blood stream and in the glycogen that is stored in the muscles.
- the human body's response to a normal buildup of lactic acid is to transport it from the cramped muscle via the blood stream to the liver where it is converted back to pyruvic acid, then to carbon dioxide, water and ATP when the oxygen supply is adequate.
- Lactic acid As the lactic acid is carried around the blood stream it impairs the body's normal function. Lactic acid is formed in large amounts during strenuous exercise, which leads to muscle cramps, fatigue and failure. Lactic acid fatigue is commonly called “the burn or hitting the wall”. This results in muscle fatigue. As more oxygen becomes available, the lactic acid is converted back to pyruvic acid, then into carbon dioxide, water and ATP. But unfortunately by this time, most humans will have quit exercising to allow the body to re-oxygenate.
- An object of the present invention is to provide compositions that enhance health and wellbeing, and methods of using them.
- the invention provides a pharmaceutical or nutraceutical composition
- a pharmaceutical or nutraceutical composition comprising an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof.
- the invention provides a method for preparing a pharmaceutical or nutraceutical composition comprising an alkalized organic substance, the method comprising mixing the organic substance with a base such that the pH of the resulting composition is between 7 and 15; wherein the organic substance is selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof.
- the invention provides a method for treating a disease or condition selected from the group comprising inflammatory diseases, congestive heart failure, ischemic heart disease, heart attack, arrhythmia, cardiomyopathy, high cholesterol and/or triglycerides; MELAS, gyrate atrophy, mitochondrial cytopathies, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, stroke, Alzheimer's disease, myopathies, Duchenne's muscular dystrophies, myophosphorylase deficiency (McArdle's disease), neuromuscular disease, muscular dystrophies, rheumatoid arthritis, osteoporosis, gout, hepatitis, cancer, viral infections and autoimmune disorders, the method comprising administering a therapeutically effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to a subject in need thereof.
- a disease or condition selected from the group comprising inflammatory diseases, con
- the invention provides a method for treating or preventing diseases or conditions associated with inflammation comprising administering a therapeutically effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to a subject in need thereof.
- an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof.
- the diseases or conditions associated with inflammation are selected from the group comprising asthma, heart disease, gingivitis and autoimmune disorders including lupus.
- the invention provides a method of increasing physical strength and/or increasing muscle mass in a subject comprising administering an effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject.
- an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject.
- the invention provides a method of increasing physical endurance and/or physical efficiency in a subject comprising administering an effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject.
- an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject.
- the invention provides a method of preparing a subject for physical activity and/or speeding up recovery of a subject after physical activity, comprising administering an effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject prior to or following the physical activity.
- the organic substance comprises a lipid, in particular one or more esterified oils, such as particular cetyl myristoleate and/or conjugated linoleic acid.
- esterified oils such as particular cetyl myristoleate and/or conjugated linoleic acid.
- the organic substance is a carbohydrate, preferably maltodextrin.
- the organic substance comprises protein, in particular whey protein concentration and/or grain protein.
- the grain protein is rice or wheat protein.
- the organic substance is an amino acid, preferably L-glutamine.
- the organic substance comprises a therapeutic agent.
- the therapeutic agent is selected from the group comprising Tribulus terrestris extract, Saw Palmetto extract, Sarsaparilla extract, Taxadrol hidafolia or mixtures thereof.
- the organic substance comprises calcium malate.
- the organic substance comprises at least one of esterified oils, maltodextrin, protein, glutamine and Tribulus terrestris extract.
- the alkalized composition comprises one or more of disodium phosphate, magnesium glycerol phosphate, magnesium stearate, di-potassium phosphate, soda ash, sodium bicarbonate, sodium phosphate and potassium phosphate.
- FIG. 1 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human acute promyelocyte leukemia HL-60 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean ⁇ sd of 8 separate experiments.
- FIG. 2 is a graph showing the effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human chronic myeloid leukemia LAMA -84 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean ⁇ sd of 8 separate experiments.
- FIG. 3 is a graph showing the effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human Hodgkin-lymphoma HD-MY-Z after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean ⁇ sd of 8 separate experiments.
- FIG. 4 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human multiple myeloma OPM-2 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean ⁇ sd of 8 separate experiments.
- FIG. 5 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human multiple myeloma U-266 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean ⁇ sd of 8 separate experiments.
- FIG. 6 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human multiple myeloma RPMI—after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean ⁇ sd of 8 separate experiments.
- alkalized organic substance refers to a composition that includes one or more organic substances and sufficient base such that the composition has a pH of between 7 and 15.
- the pH of the composition is in the range 9-15, more preferably 11-15, most preferably 12-14.
- the pH of a solid composition is defined as the pH of a 5% solution of the solid composition in deionized water.
- base refers to a chemical compound that donates hydroxy ions or absorbs hydrogen ions when dissolved in water.
- physical endurance means the ability to sustain vigorous muscle activity for at least 90 seconds, preferably at least 4 minutes, sometimes for more than 60 minutes.
- terapéuticaally effective amount means that amount of an active compound, or a material, composition or dosage form comprising an active compound, which is effective for producing some desired therapeutic or prophylactic effect, commensurate with a reasonable benefit/risk ratio.
- treatment as used herein in the context of treating a condition or disease, relates generally to treatment and therapy, whether of human or animal, in which some desired therapeutic effect is achieved, for example, the inhibition of progress of the condition, and includes a reduction in the rate of progress, a halt in the rate of progress, amelioration of the condition, and cure of the condition.
- Treatment as a prophylactic measure i.e., prophylaxis is also included.
- Treatment also includes combination treatments and therapies, in which two or more treatments or therapies are combined, for example, sequentially or simultaneously.
- a therapeutically effective amount of a compound of formula (I) could be combined with or used in conjunction with radiation therapy or chemotherapy in the treatment of cancer.
- subject refers to a human or non-human mammal.
- non-human mammals include livestock animals such as sheep, horses, cows, pigs, goats, rabbits, deer, ostriches and emus; and companion animals such as cats, dogs, rodents, and horses.
- livestock animals such as sheep, horses, cows, pigs, goats, rabbits, deer, ostriches and emus
- companion animals such as cats, dogs, rodents, and horses.
- the subject is a human.
- increasing physical efficiency means the increased ability to perform physical activity which is reflected by improvement of V02 max.
- therapeutic agents means agents that may be used to improve health or treat or prevent disease.
- Therapeutic agents include pharmaceuticals, plant or herbal extracts, nutraceuticals and antioxidants.
- the pharmaceutical or nutraceutical compositions of the invention comprise an alkalized organic substance.
- the organic substance is selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof.
- the organic substance is a lipid.
- Mixtures of different types of lipids may be used.
- the lipid is selected from the group comprising fats, oils, fatty acids, fatty esters, sterols, isoprenoids, phosphatides and cerebrosides.
- the lipid is an esterified oil or mixture of esterified oils such as cetyl myristoleate and conjugated linoleic acid.
- the pharmaceutical or nutraceutical composition consists of the lipid and base and optionally excipients.
- the organic substance is a protein, in particular whey protein concentration and/or grain protein.
- the grain protein is rice or wheat protein.
- the organic substance is a carbohydrate.
- the carbohydrate may be selected from the group comprising sugars, starches, celluloses and gums. Starch, maltodextrin and glucose are preferred carbohydrates for use in the invention.
- the organic substance is an amino acid.
- L-glutamine is a preferred amino acid for use in the invention.
- the organic substance is a vitamin.
- the vitamin is selected from the group comprising vitamin A, beta-carotene, vitamin B1, vitamin B2, vitamin B3, vitamin B6, folic acid, vitamin B12, vitamin C, vitamin D, vitamin K, niacin, pantothenic acid and biotin.
- the organic substance is a therapeutic agent.
- the therapeutic agent is an antioxidant or a herbal extract.
- Preferred therapeutic agents include saw palmetto extract, Tribulus terrestris extract, Taxadrol hidafolia, Sarsaparilla extract and summa extract.
- the alkalized compositions of the invention may be prepared by adding a base to an organic substance such that the pH of the composition is between 7-15.
- Preferred bases include disodium phosphate, magnesium glycerol phosphate, magnesium stearate, di-potassium phosphate, soda ash, sodium bicarbonate, sodium phosphate and potassium phosphate.
- compositions of the invention are pharmaceutical or nutraceutical compositions. Therefore, they contain compounds, ingredients, materials, compositions, dosage forms and the like, which are within the scope of sound medical judgment, suitable for use in contact with the tissues of the subject in question (e.g., human) without excessive toxicity, irritation, allergic response, or other problems or complications, commensurate with a reasonable benefit/risk ratio.
- the pharmaceutical or nutraceutical compositions may also comprise carriers, diluents and/or excipients. Each carrier, diluent, excipient, etc., must also be pharmaceutically or nutraceutically “acceptable” in the sense of being compatible with the other ingredients of the formulation.
- compositions formulated as liquid solutions include saline and sterile water, and may optionally include antioxidants, buffers, bacteriostats, and other common additives.
- acceptable carriers and/or diluents include saline and sterile water, and may optionally include antioxidants, buffers, bacteriostats, and other common additives.
- the compositions can also be formulated as pills, capsules, granules, tablets (coated or uncoated), (injectable) solutions, solid solutions, suspensions, dispersions, solid dispersions (e.g., in the form of ampoules, vials, creams, gels, pastes, inhaler powder, foams, tinctures, lipsticks, drops, sprays, or suppositories).
- the formulation can contain (in addition to the alkalized organic substance) fillers, disintegrators, flow conditioners, sugars and sweeteners, fragrances, preservatives, stabilizers, wetting agents, emulsifiers, solubilizers, salts for regulating osmotic pressure, buffers, diluents, dispersing and surface-active agents, binders, lubricants, and/or other pharmaceutical excipients as are known in the art.
- One skilled in this art may further formulate the compositions of the invention in an appropriate manner, and in accordance with accepted practices, such as those described in Remington's Pharmaceutical Sciences, Gennaro, Ed., Mack Publishing Co., Easton, Pa. 1990.
- the alkalized compositions may be prepared in the form of a powder, capsule, tablet, liquid, oil, soft gel or other means known in the art.
- the alkalized compositions can be taken as dietary supplements or can be incorporated into foodstuffs such as beverages, baked goods, etc.
- the amount of organic substance and type of substance can vary depending on the application and the amount and type of base added. The amount that should be administered to each subject will need to be calculated depending on the formulation, the gender, the age and the activity level of the subject.
- compositions of the invention buffer the extreme stomach acidity associated with pathological conditions such as gastritis.
- pathological conditions such as gastritis.
- the compositions of the invention prevent acidosis, thereby enhancing strength, energy, endurance and overall athletic performance.
- the alkalized organic substances of the invention provide a number of health benefits and may be useful in the treatment and prevention of a wide range of diseases.
- Example 1 provides typical formulations of the alkalized compositions of the invention.
- maltodextrin 25 g starch 25 g di-sodium phosphate 100 mg di-potassium phosphate 100 mg magnesium glycerol phosphate 25 mg
- whey protein concentrate 20 g di-sodium phosphate 100 mg di-potassium phosphate 100 mg magnesium glycerol phosphate 25 mg natural vanilla 2 mg sucralose 2 mcg
- soy bean oil 5 g calcium malate 25 mg di-sodium phosphate 25 mg tenox TM antioxidant 25 mg
- Esterified Oils consisting of cetyl 350 mg myristoleate and conjugated linoleic acid) di-sodium phosphate 25 mg Magnesium glycerol phosphate 25 mg
- Tribulus Terrestris Extract 100 mg Sarsaparilla Extract 50 mg Taxadrol hidafolia 500 mg Sodium bicarbonate 10 mg Potassium bicarbonate 10 mg
- the testing equipment used were Life Fitness computerized bicycles. These systems are able to monitor heartbeat and revolutions per minute.
- the pre test showed that the unalkalized maltodextrin group was in a bit better shape than the alkalized maltodextrin group.
- the alkalized maltodextrin group was barely able to work up to and maintain a level 4, at 100 rpms for 20 minutes, while the unalkalized maltodextrin group could maintain a level 4, at 100 rpms for 20 minutes.
- Stamina increased from 20 minutes to 40 minutes showing a 100% increase. Endurance increased from level 4 to level 6 along with the stamina increasing by 66%.
- Alkalized maltodextrin dramatically increases endurance and stamina in endurance athletes. Subjects administered alkalized maltodextrin showed stamina increases of 100% and endurance increases of 66% while unalkalized maltodextrin seem to hinder endurance and stamina.
- Alkalized Protein Administration Based on human studies, 10 grams per 100 kg of body weight was used. This worked out to 100 mcg/gram of rat starting weight. Alkalized protein was administered daily. The control group received protein of an acidic nature.
- the starting weight of both groups varied, due to different levels of maturity.
- both control rats and test rats slept during the day, with very low night activity.
- Test 1 and 2 rats were over 1.5 years old. These rats only live for two years. Test 2-6 animals were only 3 months old. So in comparison to humans, test rats 1 and 2 were like adults in their 50's or 60's and test rats 3-6 were like young adults in their teens to 20's.
- Test rats 1-2 gained an average of 10.52% in lean muscle weight.
- Test rats 3-6 gained an average of 55.73%.
- Two subjects were administered 1 capsule daily and two subjects were administered two capsules daily for 30 days. Administration was taken first thing in the morning upon awaking.
- pH, energy, endurance and physical levels were measured 3 times daily. The first in the morning before administration, the second midday, and the third in the evening. The following chart was used for measurements.
- the subjects were asked to not change their diet or workout schedules. All 4 subjects were male from ages 25-44.
- A dynamic quality (narrative energy)
- B the capacity of acting or being active (intellectual energy)
- C a usually positive spiritual force (the energy flowing through all people)
- Subject 1 Energy: 156.4% Endurance: 92.3% Physical: 50.3%
- Subject 2 Energy: 138.9% Endurance: 130.7% Physical: 125.5%
- Subject 3 Energy: 143.9% Endurance: 154.7% Physical: 127.2%
- Subject 4 Energy: 32.9% Endurance: 65.1% Physical: 30.7%
- An alkalized maltodextrin/creatine capsule increased energy levels by 118%, endurance and stamina by 110.7% and physical well being by 83.4%.
- Test subject was administered L-Glutamine HCl (pH 6.0) for 30 days. Training was three days per week, with 3 days of cardio. Dosage was 500 mg per day the first week and 1000 mg per day for week 2-4.
- Week 2-4 No noticeable changes to strength, stamina or endurance
- Test subject was taken off the glutamine HCl (pH 6.0) and administered buffered-Glutamine (pH 12.0) for 30 days. Training was three days per week, with 3 days of cardio. Dosage was 500 mg per day for the 5th week and 1000 mg per day for weeks 6-8.
- Week 6-8 Stamina levels continued to increase during the cardio and training sessions approximately by 50%
- Alkalized glutamine outperformed unmodified glutamine in the areas of strength, stamina, and endurance.
- Esterified Oils Consisting of cetyl 350 mg myristoleate and conjugated linoleic acid) di-sodium phosphate 25 mg magnesium glycerol phosphate 25 mg
- the antiproliferative effects of alkalized oil was investigated in a comparative fashion vs. non-stabilized fats in a panel of tumor cell lines, representative to some important kinds of human cancer.
- the panel included the acute promyelocyte leukemia HL-60, the chronic myeloid leukemia LAMA-84, the Hodgkin-lymphoma HD-MY-Z and the multiple myeloma-derived cell lines OPM-2, U-266 and RPMI-23366.
- All cells were obtained from the German Collection of Microorganisms and Cell Cultures (Brounschweig, Germany) and were routinely maintained under standard conditions RPMI-1640 medium, supplemented with 10% fetal calf serum and L-glutamine, in a 5% CO 2 humidified atmosphere (at 37° C.).
- the tested fats both conventional and processed, exerted strong inhibition of the proliferation of malignant cells, in a concentration-dependent manner. This allowed the calculation of the corresponding IC 50 values, i.e., concentration causing half-maximal inhibition of cell viability, as merit of the antiproliferative potency of tested compounds.
- the acute promyelocyte leukemia HL-60 demonstrated significant sensitivity to both conventional and stabilized fats, although the latter proved to be significantly more active as evident by the point-to point comparison of survival fractions for every concentration.
- the conventional fats lowered the fraction of living cells to 31.7%, while the alkalized oils decreased the percentage of viable cells to 21.9%.
- the IC 50 values were 0.41 mg/ml for the conventional fats vs. 0.32 mg/ml for the alkalized oils respectively.
- IC 50 (mg/ml) Cell line Origin Non-processed fats Buffered fats HL-60 Acute promyelocyte 0.41 ⁇ 0.07 0.32 ⁇ 0.03 leukemia LAMA-84 Chronic myeloid 0.18 ⁇ 0.04 0.12 ⁇ 0.02 leukemia HD-MY-Z Hodgkin lymphoma 0.27 ⁇ 0.04 0.22 ⁇ 0.03 OPM-2 Multiple myeloma 0.12 ⁇ 0.02 0.08 ⁇ 0.01 U-266 Multiple myeloma 0.32 ⁇ 0.05 0.24 ⁇ 0.06 RPMI Multiple myeloma 0.20 ⁇ 0.03 0.17 ⁇ 0.01
- Subject for 30 days was administered 500 mg of acidic tribulus first thing in the A.M. on an empty stomach, taken as a capsule. Subject was then switched to 500 mg of alkalized tribulus taken first thing in the A.M. on an empty stomach. Test subject was an adult male experienced in the sport of bodybuilding.
- the testing equipment was located at the local Oz Fitness Center. Testing was done once per week. No change to diet or exercise program.
- the Alkalized Tribulus showed an average increase in strength of 32.815% over the 4 lift average of Acidic Tribulus.
Abstract
Description
- Many, if not most of the foodstuffs consumed by mammals are acidic in nature. This is particularly true of processed foods such as convenience foods or “junk foods”. Many foods are made more acidic during processing to improve their taste and also to facilitate preservation. Most food preservatives are more effective in a low pH environment. In addition any additives and food preservatives are themselves acidic, for example, citric acid, malic acid, ascorbic acid, phosphoric acid, benzoic acid, acetic acid and sulphur dioxide.
- Besides ingesting a variety of acidic products, a typical modern diet is composed almost entirely of acid-forming foods, such as animal proteins, grains, legumes, and table salt (sodium chloride). Sixty percent of table salt is a reactive chloride ion which, in solution, has an affinity for hydrogen ions, generating corrosive, carcinogenic hydrochloric acid. Sebastian's team showed that chloride is responsible for salt's ability to induce hypertension, as well as urinary nitrogen and calcium losses, signaling erosion of muscle and bone.
- Unbuffered, acids dissolve calcium from bones and teeth, and facilitate soft-tissue calcification. They corrode cartilage and attack arteries, which (in self-defense) secrete a protective, buffering lipid-calcium complex. The body dilutes the acids by retaining water, but this action, combined with arteriosclerosis, creates hypertension, which can lead to heart and cerebrovascular disease.
- Acid-producing (high-protein, high-salt) diets have been shown to cause urinary stones. Salt-induced chloride acidosis has been found to cause irritability, hyperactivity and insomnia.
- Many organic substances are not stable in an acidic environment and may convert into dangerous by-products. In addition, the ingestion of acidic foods and acid-generating foods may cause the body to slip into metabolic acidosis. Acidosis is a condition in which the body's fluids tend to have a higher acid content than normal. It is a clinical disturbance caused by kidney failure due to decreased pH level characterized by an increase in total body acid. The body has a variety of ways to compensate for mild acidosis, but prolonged acid ingestion can result in weakness, headache, heavy or rapid breathing. Severe acidosis can lead to acidemia, which is a buildup of acids in the blood, resulting in a coma or death.
- A team from the department of medicine and the General Clinical Research Center at the University of California, San Francisco, led by Anthony Sebastian, recently published research revealing that typical Western diets produce slight chronic systemic metabolic acidosis in humans. The research shows that such a diet accelerates aging, corrodes muscle and bone, and suppresses growth hormone secretion (Frassetto et al. 2001, Eur J Nutr 40, pp 200-213).
- Even mild acidosis can hinder athletic performance along with every day human life. Lactic acid is a metabolic acid that is known to hinder athletic performance. Lactic acid is produced by muscle tissue to obtain energy by metabolizing glucose in the absence of oxygen.
- Lactic acid is produced by almost all tissues in the human body and is formed by glycolysis. Glycolysis is a chemical process in which glucose is broken down to pyruvic acid. The pyruvic acid, mixed with oxygen is converted to carbon dioxide, water and ATP. ATP provides energy for muscle contraction. Contracting muscles obtain ATP from glycolysis of glucose stored in the blood stream and in the glycogen that is stored in the muscles.
- At first, pyruvic acid and small amounts of ATP are generated. As the muscles continue to contract with exercise, the circulatory system cannot provide a high enough supply of oxygen. In this condition (which may occur in seconds in some individuals), most of the pyruvic acid produced in the breakdown of glucose is converted to lactic acid rather than carbon dioxide, water and ATP.
- The human body's response to a normal buildup of lactic acid is to transport it from the cramped muscle via the blood stream to the liver where it is converted back to pyruvic acid, then to carbon dioxide, water and ATP when the oxygen supply is adequate.
- As the lactic acid is carried around the blood stream it impairs the body's normal function. Lactic acid is formed in large amounts during strenuous exercise, which leads to muscle cramps, fatigue and failure. Lactic acid fatigue is commonly called “the burn or hitting the wall”. This results in muscle fatigue. As more oxygen becomes available, the lactic acid is converted back to pyruvic acid, then into carbon dioxide, water and ATP. But unfortunately by this time, most humans will have quit exercising to allow the body to re-oxygenate.
- Therefore, as the body becomes more acidic, strength, endurance and overall athletic performance including weight training, all decrease.
- An object of the present invention is to provide compositions that enhance health and wellbeing, and methods of using them.
- In one aspect the invention provides a pharmaceutical or nutraceutical composition comprising an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof.
- In another aspect the invention provides a method for preparing a pharmaceutical or nutraceutical composition comprising an alkalized organic substance, the method comprising mixing the organic substance with a base such that the pH of the resulting composition is between 7 and 15; wherein the organic substance is selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof.
- In another aspect the invention provides a method for treating a disease or condition selected from the group comprising inflammatory diseases, congestive heart failure, ischemic heart disease, heart attack, arrhythmia, cardiomyopathy, high cholesterol and/or triglycerides; MELAS, gyrate atrophy, mitochondrial cytopathies, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, stroke, Alzheimer's disease, myopathies, Duchenne's muscular dystrophies, myophosphorylase deficiency (McArdle's disease), neuromuscular disease, muscular dystrophies, rheumatoid arthritis, osteoporosis, gout, hepatitis, cancer, viral infections and autoimmune disorders, the method comprising administering a therapeutically effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to a subject in need thereof.
- In another aspect the invention provides a method for treating or preventing diseases or conditions associated with inflammation comprising administering a therapeutically effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to a subject in need thereof.
- In one embodiment the diseases or conditions associated with inflammation are selected from the group comprising asthma, heart disease, gingivitis and autoimmune disorders including lupus.
- In another aspect the invention provides a method of increasing physical strength and/or increasing muscle mass in a subject comprising administering an effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject.
- In another aspect the invention provides a method of increasing physical endurance and/or physical efficiency in a subject comprising administering an effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject.
- In another aspect the invention provides a method of preparing a subject for physical activity and/or speeding up recovery of a subject after physical activity, comprising administering an effective amount of an alkalized organic substance selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof to the subject prior to or following the physical activity.
- In the aspects of the invention described above:
- In one embodiment the organic substance comprises a lipid, in particular one or more esterified oils, such as particular cetyl myristoleate and/or conjugated linoleic acid.
- In one embodiment the organic substance is a carbohydrate, preferably maltodextrin.
- In one embodiment the organic substance comprises protein, in particular whey protein concentration and/or grain protein. Preferably, the grain protein is rice or wheat protein.
- In one embodiment the organic substance is an amino acid, preferably L-glutamine.
- In one embodiment the organic substance comprises a therapeutic agent. Preferably, the therapeutic agent is selected from the group comprising Tribulus terrestris extract, Saw Palmetto extract, Sarsaparilla extract, Taxadrol hidafolia or mixtures thereof.
- In one embodiment the organic substance comprises calcium malate.
- In one embodiment the organic substance comprises at least one of esterified oils, maltodextrin, protein, glutamine and Tribulus terrestris extract.
- In one embodiment the alkalized composition comprises one or more of disodium phosphate, magnesium glycerol phosphate, magnesium stearate, di-potassium phosphate, soda ash, sodium bicarbonate, sodium phosphate and potassium phosphate.
- The invention will now be described with reference to the drawings in which:
-
FIG. 1 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human acute promyelocyte leukemia HL-60 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean±sd of 8 separate experiments. -
FIG. 2 is a graph showing the effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human chronic myeloid leukemia LAMA-84 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean±sd of 8 separate experiments. -
FIG. 3 is a graph showing the effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human Hodgkin-lymphoma HD-MY-Z after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean±sd of 8 separate experiments. -
FIG. 4 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human multiple myeloma OPM-2 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean±sd of 8 separate experiments. -
FIG. 5 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human multiple myeloma U-266 after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean±sd of 8 separate experiments. -
FIG. 6 is a graph showing the antiproliferative effects of non-processed fats (white columns) vs. alkalized oils (grey columns) against the human multiple myeloma RPMI—after 72 h continuous exposure, as assessed by the MTT-dye reduction assay. Each data point represents the arithmetic mean±sd of 8 separate experiments. - As used herein the term “alkalized organic substance” refers to a composition that includes one or more organic substances and sufficient base such that the composition has a pH of between 7 and 15. Preferably, the pH of the composition is in the range 9-15, more preferably 11-15, most preferably 12-14.
- The pH of a solid composition is defined as the pH of a 5% solution of the solid composition in deionized water.
- As used herein the term “base” refers to a chemical compound that donates hydroxy ions or absorbs hydrogen ions when dissolved in water.
- As used herein the term “physical strength” means the ability of exerting force through muscle action.
- As used herein the term “physical endurance” means the ability to sustain vigorous muscle activity for at least 90 seconds, preferably at least 4 minutes, sometimes for more than 60 minutes.
- The term “therapeutically effective amount” as used herein, means that amount of an active compound, or a material, composition or dosage form comprising an active compound, which is effective for producing some desired therapeutic or prophylactic effect, commensurate with a reasonable benefit/risk ratio.
- The term “treatment” as used herein in the context of treating a condition or disease, relates generally to treatment and therapy, whether of human or animal, in which some desired therapeutic effect is achieved, for example, the inhibition of progress of the condition, and includes a reduction in the rate of progress, a halt in the rate of progress, amelioration of the condition, and cure of the condition. Treatment as a prophylactic measure (i.e., prophylaxis) is also included.
- “Treatment” also includes combination treatments and therapies, in which two or more treatments or therapies are combined, for example, sequentially or simultaneously. For example, a therapeutically effective amount of a compound of formula (I) could be combined with or used in conjunction with radiation therapy or chemotherapy in the treatment of cancer.
- The term “subject” as used herein refers to a human or non-human mammal. Examples of non-human mammals include livestock animals such as sheep, horses, cows, pigs, goats, rabbits, deer, ostriches and emus; and companion animals such as cats, dogs, rodents, and horses. Preferably, the subject is a human.
- The term “comprising” as used herein means “consisting at least in part of”. When interpreting each statement in this specification that includes the term “comprising”, features other than that or those prefaced by the term may also be present. Related terms such as “comprise” and “comprises” are to be interpreted in the same manner.
- As used herein the term “increasing physical efficiency” means the increased ability to perform physical activity which is reflected by improvement of V02 max.
- As used herein the term “therapeutic agents” means agents that may be used to improve health or treat or prevent disease. Therapeutic agents include pharmaceuticals, plant or herbal extracts, nutraceuticals and antioxidants.
- Alkalized Compositions of the Invention
- The pharmaceutical or nutraceutical compositions of the invention comprise an alkalized organic substance. The organic substance is selected from the group comprising proteins, carbohydrates, lipids, amino acids, vitamins, therapeutic agents and mixtures thereof.
- In one embodiment the organic substance is a lipid. Mixtures of different types of lipids may be used. In one embodiment the lipid is selected from the group comprising fats, oils, fatty acids, fatty esters, sterols, isoprenoids, phosphatides and cerebrosides.
- Preferably, the lipid is an esterified oil or mixture of esterified oils such as cetyl myristoleate and conjugated linoleic acid. Preferably the pharmaceutical or nutraceutical composition consists of the lipid and base and optionally excipients.
- In one embodiment the organic substance is a protein, in particular whey protein concentration and/or grain protein. Preferably, the grain protein is rice or wheat protein.
- In another embodiment the organic substance is a carbohydrate. The carbohydrate may be selected from the group comprising sugars, starches, celluloses and gums. Starch, maltodextrin and glucose are preferred carbohydrates for use in the invention.
- In one embodiment the organic substance is an amino acid. L-glutamine is a preferred amino acid for use in the invention.
- In a further embodiment the organic substance is a vitamin. In one embodiment the vitamin is selected from the group comprising vitamin A, beta-carotene, vitamin B1, vitamin B2, vitamin B3, vitamin B6, folic acid, vitamin B12, vitamin C, vitamin D, vitamin K, niacin, pantothenic acid and biotin.
- In yet a further embodiment the organic substance is a therapeutic agent. In one embodiment the therapeutic agent is an antioxidant or a herbal extract. Preferred therapeutic agents include saw palmetto extract, Tribulus terrestris extract, Taxadrol hidafolia, Sarsaparilla extract and summa extract.
- The alkalized compositions of the invention may be prepared by adding a base to an organic substance such that the pH of the composition is between 7-15. Preferred bases include disodium phosphate, magnesium glycerol phosphate, magnesium stearate, di-potassium phosphate, soda ash, sodium bicarbonate, sodium phosphate and potassium phosphate.
- The compositions of the invention are pharmaceutical or nutraceutical compositions. Therefore, they contain compounds, ingredients, materials, compositions, dosage forms and the like, which are within the scope of sound medical judgment, suitable for use in contact with the tissues of the subject in question (e.g., human) without excessive toxicity, irritation, allergic response, or other problems or complications, commensurate with a reasonable benefit/risk ratio. The pharmaceutical or nutraceutical compositions may also comprise carriers, diluents and/or excipients. Each carrier, diluent, excipient, etc., must also be pharmaceutically or nutraceutically “acceptable” in the sense of being compatible with the other ingredients of the formulation.
- Suitable pharmaceutically acceptable carriers and/or diluents are familiar to those skilled in the art. For compositions formulated as liquid solutions, acceptable carriers and/or diluents include saline and sterile water, and may optionally include antioxidants, buffers, bacteriostats, and other common additives. The compositions can also be formulated as pills, capsules, granules, tablets (coated or uncoated), (injectable) solutions, solid solutions, suspensions, dispersions, solid dispersions (e.g., in the form of ampoules, vials, creams, gels, pastes, inhaler powder, foams, tinctures, lipsticks, drops, sprays, or suppositories). The formulation can contain (in addition to the alkalized organic substance) fillers, disintegrators, flow conditioners, sugars and sweeteners, fragrances, preservatives, stabilizers, wetting agents, emulsifiers, solubilizers, salts for regulating osmotic pressure, buffers, diluents, dispersing and surface-active agents, binders, lubricants, and/or other pharmaceutical excipients as are known in the art. One skilled in this art may further formulate the compositions of the invention in an appropriate manner, and in accordance with accepted practices, such as those described in Remington's Pharmaceutical Sciences, Gennaro, Ed., Mack Publishing Co., Easton, Pa. 1990.
- The alkalized compositions may be prepared in the form of a powder, capsule, tablet, liquid, oil, soft gel or other means known in the art. The alkalized compositions can be taken as dietary supplements or can be incorporated into foodstuffs such as beverages, baked goods, etc. The amount of organic substance and type of substance can vary depending on the application and the amount and type of base added. The amount that should be administered to each subject will need to be calculated depending on the formulation, the gender, the age and the activity level of the subject.
- The pharmaceutical or nutraceutical compositions of the invention buffer the extreme stomach acidity associated with pathological conditions such as gastritis. In addition, by decreasing the acidic load in the body, the compositions of the invention prevent acidosis, thereby enhancing strength, energy, endurance and overall athletic performance.
- As can be seen from the Examples, the alkalized organic substances of the invention provide a number of health benefits and may be useful in the treatment and prevention of a wide range of diseases.
- The invention consists in the foregoing and also envisages constructions of which the following gives examples only.
- Example 1 provides typical formulations of the alkalized compositions of the invention.
- Formulation A
-
maltodextrin 25 g starch 25 g di- sodium phosphate 100 mg di- potassium phosphate 100 mg magnesium glycerol phosphate 25 mg - Formulation B
-
whey protein concentrate 20 g di- sodium phosphate 100 mg di- potassium phosphate 100 mg magnesium glycerol phosphate 25 mg natural vanilla 2 mg sucralose 2 mcg - Formulation C
-
maltodextrin 100 g soda ash 1 mg magnesium glycerol phosphate 15 mg Kre-Alkalyn creatine 750 mg - Formulation D
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soy bean oil 5 g calcium malate 25 mg di-sodium phosphate 25 mg tenox ™ antioxidant 25 mg - Formulation E
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L-glutamine 500 mg magnesium stearate 5 mg soda ash 2 mg sodium bicarbonate 3 mg in a gelatine capsule 100 mg - Formulation F
-
Tribulus Terrestris extract 150 mg Saw Palmetto extract 25 mg Potassium phosphate 10 mg Sodium phosphate 50 mg Gelatine capsule 100 mg - Formulation G
-
Esterified Oils (consisting of cetyl 350 mg myristoleate and conjugated linoleic acid) di-sodium phosphate 25 mg Magnesium glycerol phosphate 25 mg - Formulation H
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Tribulus Terrestris Extract 100 mg Sarsaparilla Extract 50 mg Taxadrol hidafolia 500 mg Sodium bicarbonate 10 mg Potassium bicarbonate 10 mg - Formulation I
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Whey Protein Concentrate 20 grams Grain Protein (Rice, Wheat) 5 grams di- sodium phosphate 100 mg di- potassium phosphate 100 mg Magnesium glycerol phosphate 25 mg - Study administering an alkalized maltodextrin (Formulation A)-vs-unalkalized maltodextrin to 12 endurance athletes in the off season phase.
- 6 subjects were administered 25 grams of alkalized maltodextrin 30 minutes before exercise and 6 subjects were administered 25 grams of unalkalized maltodextrin for 2 weeks. No changes were made to diet or off season training.
- Endurance and Stamina levels were tested at the beginning of the study and every day for two weeks.
- The testing equipment used were Life Fitness computerized bicycles. These systems are able to monitor heartbeat and revolutions per minute.
- The pre test showed that the unalkalized maltodextrin group was in a bit better shape than the alkalized maltodextrin group. The alkalized maltodextrin group was barely able to work up to and maintain a level 4, at 100 rpms for 20 minutes, while the unalkalized maltodextrin group could maintain a level 4, at 100 rpms for 20 minutes.
- Not much progress was made during week 1. Measurements were taken three times per week. At the end of the second week, the unalkalized maltodextrin group actually had a harder time maintaining a level 4 at 100 rpms for 20 minutes.
- Not much change in endurance was noticed during the two week period.
- And it was noticed in 5 subjects that their heart rate increased, which is a sign of fatigue.
- The results were dramatic. At the end of Week 1 and actually the very first work out, this group was able to work up to and maintain a
level 6 at 100 rpms for 20 minutes. - Stamina increased from 20 minutes to 40 minutes showing a 100% increase. Endurance increased from level 4 to
level 6 along with the stamina increasing by 66%. - Alkalized maltodextrin dramatically increases endurance and stamina in endurance athletes. Subjects administered alkalized maltodextrin showed stamina increases of 100% and endurance increases of 66% while unalkalized maltodextrin seem to hinder endurance and stamina.
- Rat Study with Alkalized Protein (Formulation B)
- White male albino rats were used for this study. A control group was used along with a test group. Upon arrival to the lab both groups entered Phase I, stabilization. Stabilization started with changing their diet to a more conventional food source. Good protein and carb levels, low fat. Each rat was weighed at the start and every three days for ten weeks. Rats were randomly selected for test group and control group.
- Rats were placed in large 10 gallon glass cages that allowed movement and building of nests. Chew items were also put in the cages to help measure night activity.
- Alkalized Protein Administration: Based on human studies, 10 grams per 100 kg of body weight was used. This worked out to 100 mcg/gram of rat starting weight. Alkalized protein was administered daily. The control group received protein of an acidic nature.
- The starting weight of both groups varied, due to different levels of maturity.
- Activity and energy levels were extremely low. Neither group was very active.
- During the stabilization phase, both control rats and test rats slept during the day, with very low night activity.
-
Results Animal Weight in grams % Gained Test 1 524.90 Start Weight 01/06/5 519.79 −.97 01/10/5 519.10 −1.10 01/13/5 531.40 1.24 01/17/5 536.00 2.11 01/20/5 538.10 2.51 01/24/5 540.80 3.02 01/27/5 540.80 3.02 01/31/5 543.50 3.54 02/03/5 542.90 3.42 02/07/5 539.10 2.70 02/10/5 536.50 2.20 02/14/5 541.30 3.12 02/17/5 542.80 3.41 02/21/5 557.80 6.26 02/24/5 555.30 5.79 02/28/5 568.30 8.26 03/05/5 562.80 7.22 03/09/5 576.30 9.79 03/14/5 573.80 9.31 03/17/5 568.30 8.26 03/21/5 571.80 8.93 03/24/5 572.30 9.03 Total Test 2 327.80 Start Weight 01/06/5 336.80 01/10/5 341.80 01/13/5 363.30 01/17/5 373.30 01/20/5 389.30 01/24/5 413.50 01/27/5 410.10 01/31/5 422.50 02/03/5 407.30 02/07/5 427.80 02/10/5 440.80 02/14/5 447.30 02/17/5 455.30 02/21/5 476.30 02/24/5 476.30 02/28/5 487.30 03/05/5 492.80 03/09/5 512.80 03/14/5 505.80 03/17/5 505.30 03/21/5 504.80 03/24/5 507.30 54.72% Total Test 3 306.30 Start Weight 01/06/5 343.80 01/10/5 344.30 01/13/5 362.00 01/17/5 371.80 01/20/5 384.20 01/24/5 408.80 01/27/5 409.80 01/31/5 423.10 02/03/5 410.00 02/07/5 424.25 02/10/5 444.80 02/14/5 448.80 02/17/5 463.30 02/21/5 463.30 02/24/5 473.80 02/28/5 480.30 03/05/5 481.80 03/09/5 506.80 03/14/5 496.80 03/17/5 499.30 03/21/5 495.80 03/24/5 491.80 60.56% Total Test 4 598.80 Start Weight 01/06/5 601.30 01/10/5 600.80 01/13/5 610.50 01/17/5 610.80 01/20/5 611.30 01/24/5 616.20 01/27/5 618.80 01/31/5 619.40 02/03/5 619.80 02/07/5 621.10 02/10/5 624.30 02/14/5 633.30 02/17/5 637.30 02/21/5 637.80 02/24/5 637.90 02/28/5 648.80 03/05/5 658.80 03/09/5 659.30 03/14/5 664.80 03/17/5 665.80 03/21/5 669.80 03/24/5 670.80 12.02% Total Test 5 335.89 Start Weight 01/06/5 342.80 01/10/5 338.80 01/13/5 374.30 01/17/5 380.20 01/20/5 387.80 01/24/5 418.80 01/27/5 418.80 01/31/5 430.20 02/03/5 433.30 02/07/5 439.20 02/10/5 444.30 02/14/5 459.30 02/17/5 467.30 02/21/5 475.80 02/24/5 486.30 02/28/5 492.80 03/05/5 494.30 03/09/5 509.30 03/14/5 509.80 03/17/5 509.80 03/21/5 513.00 03/24/5 515.00 53.32% Total Test 6 307.80 Start Weight 01/06/5 320.30 01/10/5 323.80 01/13/5 350.00 01/17/5 357.80 01/20/5 370.80 01/24/5 395.80 01/27/5 404.00 01/31/5 410.60 02/03/5 412.20 02/07/5 413.40 02/10/5 429.80 02/14/5 429.80 02/17/5 429.90 02/24/5 434.30 02/28/5 441.80 03/05/5 441.80 03/09/5 470.80 03/14/5 473.80 03/17/5 473.80 03/21/5 473.80 03/24/5 475.00 54.32% Total - There were two ages of groups used for the study. Test 1 and 2 rats were over 1.5 years old. These rats only live for two years. Test 2-6 animals were only 3 months old. So in comparison to humans, test rats 1 and 2 were like adults in their 50's or 60's and test rats 3-6 were like young adults in their teens to 20's.
- Test rats 1-2 gained an average of 10.52% in lean muscle weight. Test rats 3-6 gained an average of 55.73%.
- Feeding rats alkalized protein increased their gain in lean muscle in seniors by 10.52% and young adults by 55.73%. All rats had more energy and their coats looked healthier and whiter with overall moods appearing to be positive.
- Case Study administering an alkalized maltodextrin/creatine capsule (Formulation C) to 4 Healthy active adults.
- To measure body pH, energy levels, endurance levels, and physical wellbeing in test subjects.
- Two subjects were administered 1 capsule daily and two subjects were administered two capsules daily for 30 days. Administration was taken first thing in the morning upon awaking.
- pH, energy, endurance and physical levels were measured 3 times daily. The first in the morning before administration, the second midday, and the third in the evening. The following chart was used for measurements.
-
Scale: 1-5 Number System Energy Endurance Physical 1—Very energetic 1—Very 1—Feel Great 2—Fairly 2—Good 2—Good 3—So-So 3—So-So 3—So-So 4—A bit sluggish 4—Not so good 4—Not so good 5—No energy 5—Bad 5—Bad pH was measured by urinalysis. - The subjects were asked to not change their diet or workout schedules. All 4 subjects were male from ages 25-44.
- Energy
- 1). A: dynamic quality (narrative energy) B: the capacity of acting or being active (intellectual energy) C: a usually positive spiritual force (the energy flowing through all people)
- 2). Vigorous exertion of power: EFFORT (investing time and energy)
- 3). A fundamental entity of nature that is transferred between parts of a system in the production of physical change within the system and usually regarded as the capacity for doing work
- 4). usable power (as heat or electricity); also: the resources for producing such power
- Endurance
- 1). Permanence, duration
- 2). The ability to withstand hardship or adversity; especially: the ability to sustain a prolonged stressful effort or activity (a marathon runner's endurance)
- 3). The act or an instance of enduring or suffering
- 4). Capacity to endure pain or hardship, fortitude, stamina
- Physical*
- 1). A emotional state or action
- 2). The overall quality of one's awareness and well-being
- 3). Strength and power
-
Results Subject 1: Energy Before study: 3.00 (So-So) During study: 1.17 (Average) Very Energetic Endurance Before study: 3.00 (So-So) During study: 1.56 (Average) Very Physical Before study: 2.00 (Good) During study: 1.33 (Average) Feel Great Subject 2: Energy Before study: 3.00 (So-So) During study: 1.26 (Average) Very Energetic Endurance Before study: 3.00 (So-So) During study: 1.30 (Average) Very Physical Before study: 3.00 (Good) During study: 1.33 (Average) Feel Great Subject 3: Energy Before study: 4.00 (A bit sluggish) During study: 1.64 (Average) Very Energetic Endurance Before study: 4.00 (Not so good) During study: 1.57 (Average) Very Physical Before study: 4.00 (Not so good) During study: 1.76 (Average) Feel Great Subject 4: Energy Before study: 5.00 (No energy) During study: 3.76 (Average) So-So Endurance Before study: 5.00 (Bad) During study: 3.03 (Average) So-So Physical Before study: 4.00 (Not so good) During study: 3.06 (Average) So-So -
-
Subject 1: Energy: 156.4% Endurance: 92.3% Physical: 50.3% Subject 2: Energy: 138.9% Endurance: 130.7% Physical: 125.5% Subject 3: Energy: 143.9% Endurance: 154.7% Physical: 127.2% Subject 4: Energy: 32.9% Endurance: 65.1% Physical: 30.7% - Energy: 118.0%
- Endurance: 110.7%
- Physical: 83.4%
- An alkalized maltodextrin/creatine capsule increased energy levels by 118%, endurance and stamina by 110.7% and physical well being by 83.4%.
- By buffering this oil, we were able to extend the use life of this oil from 1 day (prior art, low pH) to 7 days. This saves the food industry six oil changes a day for frying foods.
- Week 1-4:
- Test subject was administered L-Glutamine HCl (pH 6.0) for 30 days. Training was three days per week, with 3 days of cardio. Dosage was 500 mg per day the first week and 1000 mg per day for week 2-4.
- Week 1: No noticeable changes to strength, stamina or endurance
- Week 2-4: No noticeable changes to strength, stamina or endurance
- Weeks 5-8:
- Test subject was taken off the glutamine HCl (pH 6.0) and administered buffered-Glutamine (pH 12.0) for 30 days. Training was three days per week, with 3 days of cardio. Dosage was 500 mg per day for the 5th week and 1000 mg per day for weeks 6-8.
- Week 5: Stamina levels increased during the cardio and training sessions
- Week 6-8: Stamina levels continued to increase during the cardio and training sessions approximately by 50%
- Strength levels increased by 10%
- Endurance levels increased by 35%
- Alkalized glutamine outperformed unmodified glutamine in the areas of strength, stamina, and endurance.
-
-
Esterified Oils (Consisting of cetyl 350 mg myristoleate and conjugated linoleic acid) di-sodium phosphate 25 mg magnesium glycerol phosphate 25 mg - The antiproliferative effects of alkalized oil (Formula G) was investigated in a comparative fashion vs. non-stabilized fats in a panel of tumor cell lines, representative to some important kinds of human cancer. The panel included the acute promyelocyte leukemia HL-60, the chronic myeloid leukemia LAMA-84, the Hodgkin-lymphoma HD-MY-Z and the multiple myeloma-derived cell lines OPM-2, U-266 and RPMI-23366. All cells were obtained from the German Collection of Microorganisms and Cell Cultures (Brounschweig, Germany) and were routinely maintained under standard conditions RPMI-1640 medium, supplemented with 10% fetal calf serum and L-glutamine, in a 5% CO2 humidified atmosphere (at 37° C.).
- For the cytotoxicity assessment exponentially growing cells were plated in 96-well flat-bottomed microplates and after 24 h were treated with the tested fats. The tested compounds were dissolved in DMSO and serially diluted in RPMI-1640 to the desired level. For each concentration at least 8 wells were used. After 72 h exposure the cellular viability was monitored by the standard MTT-dye reduction assay, as described elsewhere [1], with minor modification [2].
- The tested fats, both conventional and processed, exerted strong inhibition of the proliferation of malignant cells, in a concentration-dependent manner. This allowed the calculation of the corresponding IC50 values, i.e., concentration causing half-maximal inhibition of cell viability, as merit of the antiproliferative potency of tested compounds.
- The acute promyelocyte leukemia HL-60 demonstrated significant sensitivity to both conventional and stabilized fats, although the latter proved to be significantly more active as evident by the point-to point comparison of survival fractions for every concentration. At the highest level evaluated (1 mg/ml) the conventional fats lowered the fraction of living cells to 31.7%, while the alkalized oils decreased the percentage of viable cells to 21.9%. The IC50 values were 0.41 mg/ml for the conventional fats vs. 0.32 mg/ml for the alkalized oils respectively.
- Significant antiproliferative effects were established in LAMA-84 cells as well. As in the preceding cell line, the stabilized, alkalized oils proved to be superior antiproliferative agents as evidenced by the MTT-data. At the highest concentration tested the non-processed fats reduced the cellular viability by ca. 79%, while the alkalized oils lowered it by approximately 84%. The IC50 values obtained were 0.18 mg/ml for the conventional and 0.12 mg/ml for the alkalized oils.
- The evaluation of the antiproliferative effects of tested compounds against the Hodgkin lymphoma derived cell line HD-MY-Z revealed that they exerted strong inhibitory activity, again superior for the alkalized oils. At a concentration of 1 mg/ml the viable cells were 30.7 after exposure to conventional fats and 26.8 after treatment with alkalized oils. The superiority of the alkalized oils in terms of potency is corroborated by the calculated IC50 values-0.27 mg/ml for the conventional fats vs. 0.22 mg/ml for the processed ones.
- The results for the three multiple myeloma-derived cell lines also demonstrated the superiority of the alkalized oils, vs. the non-stabilized ones. The presented data indicate that throughout the panel of malignant cells the alkalized oils proved to exert superior antiproliferative effects vs. the non-buffered ones, as evidenced by point-to-point comparison of survival fractions after treatment with equivalent concentrations as well as by juxtaposition of the calculated IC50 values. It is well appreciated in the art, that the antiproliferative potency of a given compound in vitro is governed by its stability under the experimental conditions. Thus, considering the equivalent controlled conditions of the experiment, the observed greater activity of alkalized oils could be ascribed solely to the superior stability afforded by the processing manipulations.
-
- 1. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods, 1983, 65(1-2): p. 55-63.
- 2. Konstantinov, S. M., H. Eibl, and M. R. Berger, BCR-ABL influences the antileukaemic efficacy of alkylphosphocholines. Br J Haematol, 1999, 107(2): p. 365-80.
- TABLE 1. Antiproliferative effects of non-processed fats vs. alkalized oils in a panel of human tumor cell lines, as assessed by the MTT-dye reduction assay after 72 h continuous exposure.
-
IC50 (mg/ml) Cell line Origin Non-processed fats Buffered fats HL-60 Acute promyelocyte 0.41 ± 0.07 0.32 ± 0.03 leukemia LAMA-84 Chronic myeloid 0.18 ± 0.04 0.12 ± 0.02 leukemia HD-MY-Z Hodgkin lymphoma 0.27 ± 0.04 0.22 ± 0.03 OPM-2 Multiple myeloma 0.12 ± 0.02 0.08 ± 0.01 U-266 Multiple myeloma 0.32 ± 0.05 0.24 ± 0.06 RPMI Multiple myeloma 0.20 ± 0.03 0.17 ± 0.01 -
-
Tribulus Terrestris Extract 500 mg Sodium bicarbonate 10 mg Potassium bicarbonate 10 mg - To see if alkalized tribulus herb outperforms acidic tribulus herb.
- Subject for 30 days was administered 500 mg of acidic tribulus first thing in the A.M. on an empty stomach, taken as a capsule. Subject was then switched to 500 mg of alkalized tribulus taken first thing in the A.M. on an empty stomach. Test subject was an adult male experienced in the sport of bodybuilding.
- Strength levels were noted at the beginning of the study based on the following lifts:
-
- Declined chest press
- Leg Press
- Shoulder Press
- Pull downs
- The testing equipment was located at the local Oz Fitness Center. Testing was done once per week. No change to diet or exercise program.
-
-
Declined chest press 185 lbs × 10 reps Leg Press 405 lbs × 10 reps Shoulder Press 90 lbs × 10 reps Pull downs 150 lbs × 10 reps -
-
Declined chest press 185 lbs × 10 reps Leg Press 405 lbs × 10 reps Shoulder Press 90 lbs × 10 reps Pull downs 150 lbs × 10 reps -
-
Declined chest press 190 lbs × 10 reps Leg Press 425 lbs × 10 reps Shoulder Press 95 lbs × 10 reps Pull downs 160 lbs × 10 reps -
-
Declined chest press 190 lbs × 10 reps Leg Press 425 lbs × 10 reps Shoulder Press 95 lbs × 10 reps Pull downs 160 lbs × 10 reps -
-
Declined chest press 195 lbs × 10 reps Leg Press 435 lbs × 10 reps Shoulder Press 95 lbs × 10 reps Pull downs 170 lbs × 10 reps -
-
Declined chest press 225 lbs × 10 reps Leg Press 455 lbs × 10 reps Shoulder Press 100 lbs × 10 reps Pull downs 170 lbs × 10 reps -
-
Declined chest press 245 lbs × 10 reps Leg Press 495 lbs × 10 reps Shoulder Press 105 lbs × 10 reps Pull downs 190 lbs × 10 reps -
-
Declined chest press 275 lbs × 10 reps Leg Press 585 lbs × 10 reps Shoulder Press 110 lbs × 10 reps Pull downs 180 lbs × 10 reps -
-
Declined chest press 315 lbs × 10 reps Leg Press 605 lbs × 10 reps Shoulder Press 125 lbs × 10 reps Pull downs 200 lbs × 10 reps - The alkalization of tribulus-vs-acidic tribulus results were overwhelming.
-
Acidic Alkalized Tribulus % Tribulus % Increase Increase Declined press 5.4% 70.27% Leg Press 7.4% 19.38% Shoulder Press 5.5% 39.88% Pull downs 13.3 33.33% - On a 4 lift average, the Alkalized Tribulus showed an average increase in strength of 32.815% over the 4 lift average of Acidic Tribulus.
- The above examples illustrate the practice of the invention. It will be appreciated by those skilled in the art that the invention can be carried out with numerous modifications and variations.
- While the fundamental novel features of the invention have been shown and described, it should be understood that various substitutions, modifications, and variations may be made by those skilled in the arts, without departing from the spirit or scope of the invention. Accordingly, all such modifications or variations are included in the scope of the invention as defined by the following claims:
Claims (17)
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US17/023,150 US11376282B2 (en) | 2009-08-26 | 2020-09-16 | Alkalized organic pharmaceutical or nutraceutical composition |
US17/828,573 US20220288126A1 (en) | 2009-08-26 | 2022-05-31 | Alkalized organic pharmaceutical or nutraceutical composition |
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US27519009P | 2009-08-26 | 2009-08-26 | |
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US13/998,672 US20150164937A1 (en) | 2009-08-26 | 2013-11-21 | Pharmaceutical or nutraceutical composition |
US15/096,166 US20160220610A1 (en) | 2009-08-26 | 2016-04-11 | Pharmaceutical or nutraceutical composition |
US15/948,868 US20190083541A1 (en) | 2009-08-26 | 2018-04-09 | Alkalized organic pharmaceutical or nutraceutical composition |
US17/023,150 US11376282B2 (en) | 2009-08-26 | 2020-09-16 | Alkalized organic pharmaceutical or nutraceutical composition |
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US15/096,166 Abandoned US20160220610A1 (en) | 2009-08-26 | 2016-04-11 | Pharmaceutical or nutraceutical composition |
US15/948,868 Abandoned US20190083541A1 (en) | 2009-08-26 | 2018-04-09 | Alkalized organic pharmaceutical or nutraceutical composition |
US17/023,150 Active US11376282B2 (en) | 2009-08-26 | 2020-09-16 | Alkalized organic pharmaceutical or nutraceutical composition |
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US15/096,166 Abandoned US20160220610A1 (en) | 2009-08-26 | 2016-04-11 | Pharmaceutical or nutraceutical composition |
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ES2558112T3 (en) | 2010-12-29 | 2016-02-02 | Abbott Laboratories | Nutritional products that include a new lipid system that includes monoglycerides |
NZ711956A (en) | 2013-03-08 | 2018-06-29 | Axiom Foods Inc | Rice protein supplements |
US9820504B2 (en) | 2013-03-08 | 2017-11-21 | Axiom Foods, Inc. | Rice protein supplement and methods of use thereof |
WO2018209131A1 (en) | 2017-05-12 | 2018-11-15 | Axiom Foods, Inc. | Rice products and systems and methods for making thereof |
WO2022039215A1 (en) * | 2020-08-21 | 2022-02-24 | アサヒグループホールディングス株式会社 | Muscle breakdown inhibitor |
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US4267197A (en) | 1978-06-21 | 1981-05-12 | Pacific Kenyon Corporation | Animal feed supplement as a thixotropic stable suspension |
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JPS58134963A (en) | 1982-02-03 | 1983-08-11 | Masuda Teruo | Preparation of soybean food |
US4994284A (en) * | 1986-06-27 | 1991-02-19 | Union Oil Company Of California | Animal feed supplement suspension |
DK179687D0 (en) | 1987-04-08 | 1987-04-08 | Farma Food As | PREPARATION |
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2010
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- 2010-08-26 US US12/807,067 patent/US20110052729A1/en not_active Abandoned
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2013
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2018
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US20110052729A1 (en) | 2011-03-03 |
US11376282B2 (en) | 2022-07-05 |
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US20150164937A1 (en) | 2015-06-18 |
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