US20200330537A1 - Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use - Google Patents
Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use Download PDFInfo
- Publication number
- US20200330537A1 US20200330537A1 US16/921,231 US202016921231A US2020330537A1 US 20200330537 A1 US20200330537 A1 US 20200330537A1 US 202016921231 A US202016921231 A US 202016921231A US 2020330537 A1 US2020330537 A1 US 2020330537A1
- Authority
- US
- United States
- Prior art keywords
- tobacco
- cannabidiol
- cannabinoid
- matter
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000208125 Nicotiana Species 0.000 title claims abstract description 89
- 235000002637 Nicotiana tabacum Nutrition 0.000 title claims abstract description 89
- 229930003827 cannabinoid Natural products 0.000 title claims abstract description 76
- 239000003557 cannabinoid Substances 0.000 title claims abstract description 76
- 235000019505 tobacco product Nutrition 0.000 title abstract description 20
- 230000006378 damage Effects 0.000 title abstract description 13
- 239000000654 additive Substances 0.000 title description 28
- 238000000034 method Methods 0.000 title description 12
- 235000019504 cigarettes Nutrition 0.000 claims abstract description 26
- QHMBSVQNZZTUGM-UHFFFAOYSA-N Trans-Cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-UHFFFAOYSA-N 0.000 claims description 50
- ZTGXAWYVTLUPDT-UHFFFAOYSA-N cannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1C1C(C(C)=C)CC=C(C)C1 ZTGXAWYVTLUPDT-UHFFFAOYSA-N 0.000 claims description 50
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical compound OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 claims description 50
- 229950011318 cannabidiol Drugs 0.000 claims description 50
- PCXRACLQFPRCBB-ZWKOTPCHSA-N dihydrocannabidiol Natural products OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)C)CCC(C)=C1 PCXRACLQFPRCBB-ZWKOTPCHSA-N 0.000 claims description 50
- CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 claims description 37
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims description 37
- 229960004242 dronabinol Drugs 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 31
- 235000019506 cigar Nutrition 0.000 claims description 8
- 241000218236 Cannabis Species 0.000 claims description 7
- 230000001055 chewing effect Effects 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 6
- 230000009931 harmful effect Effects 0.000 claims 3
- 229940065144 cannabinoids Drugs 0.000 abstract description 33
- 206010007269 Carcinogenicity Diseases 0.000 abstract description 4
- 230000007670 carcinogenicity Effects 0.000 abstract description 4
- 231100000260 carcinogenicity Toxicity 0.000 abstract description 4
- 239000000284 extract Substances 0.000 abstract description 3
- 230000007794 irritation Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 3
- 240000004308 marijuana Species 0.000 abstract 1
- ZROLHBHDLIHEMS-HUUCEWRRSA-N (6ar,10ar)-6,6,9-trimethyl-3-propyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCC)=CC(O)=C3[C@@H]21 ZROLHBHDLIHEMS-HUUCEWRRSA-N 0.000 description 18
- UCONUSSAWGCZMV-HZPDHXFCSA-N Delta(9)-tetrahydrocannabinolic acid Chemical compound C([C@H]1C(C)(C)O2)CC(C)=C[C@H]1C1=C2C=C(CCCCC)C(C(O)=O)=C1O UCONUSSAWGCZMV-HZPDHXFCSA-N 0.000 description 18
- ZROLHBHDLIHEMS-UHFFFAOYSA-N Delta9 tetrahydrocannabivarin Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCC)=CC(O)=C3C21 ZROLHBHDLIHEMS-UHFFFAOYSA-N 0.000 description 18
- 230000000996 additive effect Effects 0.000 description 10
- UVOLYTDXHDXWJU-UHFFFAOYSA-N Cannabichromene Chemical compound C1=CC(C)(CCC=C(C)C)OC2=CC(CCCCC)=CC(O)=C21 UVOLYTDXHDXWJU-UHFFFAOYSA-N 0.000 description 9
- REOZWEGFPHTFEI-JKSUJKDBSA-N Cannabidivarin Chemical compound OC1=CC(CCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 REOZWEGFPHTFEI-JKSUJKDBSA-N 0.000 description 9
- VBGLYOIFKLUMQG-UHFFFAOYSA-N Cannabinol Chemical compound C1=C(C)C=C2C3=C(O)C=C(CCCCC)C=C3OC(C)(C)C2=C1 VBGLYOIFKLUMQG-UHFFFAOYSA-N 0.000 description 9
- WVOLTBSCXRRQFR-DLBZAZTESA-N cannabidiolic acid Chemical compound OC1=C(C(O)=O)C(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 WVOLTBSCXRRQFR-DLBZAZTESA-N 0.000 description 9
- QXACEHWTBCFNSA-SFQUDFHCSA-N cannabigerol Chemical compound CCCCCC1=CC(O)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1 QXACEHWTBCFNSA-SFQUDFHCSA-N 0.000 description 9
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 5
- 230000003110 anti-inflammatory effect Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000000605 extraction Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229960002715 nicotine Drugs 0.000 description 5
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 5
- 238000003384 imaging method Methods 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 239000000779 smoke Substances 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000002059 diagnostic imaging Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000001773 anti-convulsant effect Effects 0.000 description 1
- 230000003474 anti-emetic effect Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000002111 antiemetic agent Substances 0.000 description 1
- 229960003965 antiepileptics Drugs 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000013070 change management Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 231100000567 intoxicating Toxicity 0.000 description 1
- 230000002673 intoxicating effect Effects 0.000 description 1
- 238000007648 laser printing Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/302—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by natural substances obtained from animals or plants
- A24B15/303—Plant extracts other than tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B3/00—Preparing tobacco in the factory
- A24B3/12—Steaming, curing, or flavouring tobacco
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D1/00—Cigars; Cigarettes
- A24D1/002—Cigars; Cigarettes with additives, e.g. for flavouring
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
- A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
- A24D3/06—Use of materials for tobacco smoke filters
- A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Definitions
- the present invention relates to tobacco products such as cigarettes, cigars, pipe tobacco (bulk), roll your own, and smokeless tobacco products also known as “snuff,” “chewing tobacco,” and “dipping tobacco.” More particularly, novel forms of tobacco and tobacco products including, cured and uncured leaves, which include as additives one or more cannabinoids as health enhancing, harm reduction, and/or experience enhancing agents.
- the present invention relates generally to software, and more particularly, to a patient information synchronization system.
- a picture archiving and communication system is a medical imaging technology that provides economical storage and convenient access to images from multiple source machines. Electronic images and reports are transmitted digitally via PACS, which eliminates the need to manually file, retrieve, or transport physical film jackets.
- the universal format for PACS image storage and transfer is known as digital imaging and communications in medicine (DICOM).
- Non-image data, such as documents, may be incorporated using standard document formats such as portable document format (PDF) which are encapsulated in DICOM.
- PDF portable document format
- a PACS system provides archives for storage of multi-modality images, integrates images with patient database information, facilitates laser printing of images, and displays both images and patient information at work stations throughout the network and at remote locations.
- a vendor neutral archive is a medical imaging technology in which images and documents are archived in a standard format with a standard interface, such that they can be accessed in a vendor-neutral manner by other systems.
- VNA vendor neutral archive
- a VNA system provides similar functionality as a PACS system without the vendor-specific applicability, namely radiology, though further incorporates storage of non-DICOM content and access protocols.
- One such type of non-DICOM content is known as health level-7 (HL7), which is a set of international standards for the transfer of clinical and administrative data between software applications used by various healthcare providers.
- Imaging Object Change Management specifies how one actor communicates local changes applied on existing imaging objects to other actors that manage copies of the modified imaging objects in their own local systems.
- the supported changes include object
- a first aspect of the present invention there is provided an effective technique for adding cannabinoids to cigarettes, cigars, bulk tobacco (including leaves), reconstituted tobacco, pipe tobacco and smokeless snuff, “moist snuff” or “chewing” tobacco (as smokeless tobacco is commonly known) as well as to non-tobacco smokable and mouthable products.
- the cannabinoid added to the tobacco is (tetrahydrocannbinol) THC.
- the cannabinoid is cannabidiol (CBD).
- the cannabinoid is selected from the group consisting of tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- THCA tetrahydrocannabinolic acid
- CBDA cannabidiolic acid
- CBN cannabinol
- CBG cannabigerol
- CBC cannabichromene
- THCV cannabidivarin
- CBDDV cannabidivarin
- a tobacco product selected from the group consisting of cigarettes, cigars, bulk tobacco (including leaves), reconstituted tobacco, pipe tobacco and smokeless snuff or “chewing” tobacco (as smokeless tobacco is commonly known) as well as to non-tobacco smokable and mouthable products, further comprising the addition of one or more cannabinoids selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- THC tetrahydrocannabinol
- CBD cannabidiol
- THCA tetrahydrocannabinolic acid
- CBDA cannabidiolic acid
- a method for reducing the harm associated with tobacco use in a subject in need thereof comprising the steps of providing to that user a tobacco product further comprising the addition of one or more cannabinoids selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- THC tetrahydrocannabinol
- CBD cannabidiol
- THCA tetrahydrocannabinolic acid
- CBDA cannabidiolic acid
- CBD cannabinol
- CBG cannabigerol
- CBC cannabichromene
- THCV cannabidi
- the cannabinoids used may be isolated using any methods known by those having skill in the art, including the use of hydrocarbon solvents and solventless extraction. Therefore in one embodiment the cannabinoids used as additives are produced by extraction of cannabis plant material with supercritical or subcritical CO2. In an alternative embodiment the cannabinoid additives are produced by extraction from plant material by volatilisation with a heated gas. In an alternative embodiment the cannabinoid additives are produced from plant material through the sequential processes of CO2 extraction followed by fractional distillation. In some embodiments, the cannabinoid additives contain all of the naturally occurring cannabinoids in the plant material. Alternatively, synthetic or highly purified isolates of the cannabinoids can be used.
- the term “approximately equal” is used to refer to ratios of cannabinoids which are in the range of between 0.9:1 to 1:0.9 (THC: CBD). Additionally the term “1:1” is taken herein to refer to approximately equal amounts of cannabinoids .
- the cannabinoids are a class of molecules primarily obtained through the extraction of cannabis plant material.
- the various cannabinoids include tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV) as well as others.
- Various cannabinoids, used alone or in combination have shown a variety of significant biological effects including but not limited to pain relief, anti cancer, anti inflammatory, anti emetic, anti convulsant, and several others.
- CBD cannabinoid additives for tobacco
- CBD is particularly useful due to its non-intoxicating, antineoplastic, anti-inflammatory, and pain relieving effects. While specific embodiments of tobacco products including cannabinoids are discussed with respect to CBD, it is noted that other cannabinoids may be added to or substituted depending on the specific effects desired from the additives. Therefore, in an embodiment, a substantially pure, dry powder of CBD is mixed directly with the tobacco used in smokable or smokeless tobacco during the manufacturing process and/or directly into smokable or smokeless tobacco products. CBD can also be inserted or mixed into mixtures of lamina tobaccos, reconstituted tobacco and lamina tobacco mixed with reconstituted tobacco as well as into a cigarette filter, holder, paper or wrapper.
- cannabinoid additives namely oils can be used in the present invention. Oils may be particularly useful do the fact that it is difficult to get substantially pure, solid forms of many cannabinoids. Oils may be particularly useful in chewing tobacco, and as a coating for the interior surface of cigarette and cigar wrappers. Other formulations of cannabinoids may be incorporated into tobacco products such as microencapsulated, particleized cannabinoids.
- Cannabinoids can be incorporated into a tobacco or non tobacco product in a number of different ways including being directly mixed with the tobacco or inserted into a cigarette/cigar filter, holder, or wrapper either in a dry, oil, or microencapsulated form.
- a substantially pure, “dry” form of CBD can be blended into, sprayed or dusted onto the full or cut tobacco or non-tobacco leaves during the curing or manufacturing process. In that way, the substantially pure, “dry” form of CBD will already be incorporated onto the tobacco when it is rolled into the cigarette packaged in a bulk smokeless container.
- CBD can vary, it is expected that between 0.1 and 5000 milligrams of CBD or other cannabinoid would be a suitable amount for a cigarette or smokeless tobacco wad containing 400-1200 milligrams of tobacco, with a more preferred amount of CBD or other cannabinoid to be between 0.1% to 20.0% by weight of tobacco or 0.4 milligrams to 240 milligrams for a cigarette or smokeless tobacco wad containing 400-1200 milligram of tobacco.
- the cannabinoids are added by adding an amount of a whole plant cannabis extract.
- the tobacco and cannabinoid additives are provided as a kit comprising separate portions of tobacco and cannabinoid extracts, enabling users to combine the tobacco and cannabinoid additives in proportions of their choosing.
- the cannabinoid(s) are incorporated into the cigarette filter either as dispersed particles, liquid infused into the filter medium or microencapsulated particles.
- the cannabinoid(s) may also be incorporated into tobacco paper, plug wrap, and or filter paper.
- the cannabinoid(s) are added to the tobacco after the tobacco has been dried, cured and otherwise processed to be ready for formulation into cigarettes, smokeless and other forms.
- the addition of cannabinoids at this stage is beneficial as it avoids the possibility of degradation of the cannabinoids over time and during the processing steps of the raw tobacco leaves. It also has the added benefit of enabling a more accurate and precise dosage of cannabinoid(s).
- terpenes either alone or in combination with cannabinoids are added as additives to the tobacco products.
- the cannabinoids present as additives are THC and CBD present in ratios in the range of 1:100 to 100:1, particularly between 1:20 to 20:1. In some embodiments the cannabinoids present are THC and CBD in a 1:1 ratio.
- cannabinoid additives to tobacco products, especially as a harm reduction measure.
- One benefit is the reduced irritation associated with tobacco product use.
- CBD with its known anti inflammatory and pain relieving properties is particularly beneficial in reducing some of the discomfort associated with tobacco use.
- THC as an additive to tobacco products is beneficial, especially in states where the recreational use of cannabis is permitted and as a way to reduce the nausea that sometimes accompanies tobacco use.
- cannabinoids as tobacco additives, may be particularly useful as a mechanism to reduce the carcinogenicity associated with tobacco products.
- Substantial evidence has been presented that these compounds can reduce tumor growth in animal models of cancer.
- a large body of scientific evidences strongly support THC and other cannabinoid agonists exert anticancer actions in preclinical models of cancer (including immunocompetent mice) through a well-established mechanism of action.
- Cannabinoids as Anticancer Agents— Velasco et al. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Jan. 4 2016, which is hereby incorporated by reference in its entirety.
- cannabinoids as tobacco additives, may be particularly useful as a mechanism to reduce the inflammatory response often caused by the use of tobacco products.
- tobacco use is known to cause various inflammatory responses including but not limited to inflammation and irritation of the mouth and throat.
- Various cannabinoids are known to have an anti-inflammatory effect. See ie Comparative topical anti - inflammatory activity of cannabinoids and cannbivarins— Tubaro et al. Fitorick, (2010) 816-819, which is hereby incorporated by reference in its entirety.
- the invention is a smokable or non smokable composition
- tobacco at least one additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- THC tetrahydrocannabinol
- CBD cannabidiol
- THCA cannabidiolic acid
- CBDA cannabinol
- CBG cannabigerol
- CBC cannabichromene
- THCV cannabidivarin
- CBDV cannabidivarin
- Another embodiment is, method of reducing the harm associated with tobacco use comprising providing tobacco users with tobacco products to which have been added at least one cannabinoid selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- THC tetrahydrocannabinol
- CBD cannabidiol
- THCA cannabidiolic acid
- CBDA cannabinol
- CBG cannabigerol
- CBC cannabichromene
- THCV cannabidivarin
- CBDV cannabidivarin
- Another embodiment is a tobacco mixture with a reduced carcinogenicity profile comprising tobacco with a cannabinoid additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- a cannabinoid additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivari
- Another embodiment is method for reducing free radical damage to the oro-pharyngeal cavity, respiratory tract and lungs from tobacco smoke, the method comprising adding a cannabinoid additive to tobacco products, the additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- THC tetrahydrocannabinol
- CBD cannabidiol
- THCA tetrahydrocannabinolic acid
- CBDA cannabidiolic acid
- CBD cannabinol
- CBG cannabigerol
- CBC cannabichromene
- THCV can
- a cigarette comprising a paper wrapper surrounding a charge of tobacco, said cigarette further comprising a composition for reducing free radical damage to the oro-pharyngeal cavity, respiratory tract and lungs from tobacco smoke generated by said cigarette, said composition comprising a cannabinoid additive to tobacco products, the additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- THC tetrahydrocannabinol
- CBD cannabidiol
- THCA tetrahydrocannabinolic acid
- CBDA cannabidiolic acid
- CBD cannabino
Abstract
Description
- The present invention relates to tobacco products such as cigarettes, cigars, pipe tobacco (bulk), roll your own, and smokeless tobacco products also known as “snuff,” “chewing tobacco,” and “dipping tobacco.” More particularly, novel forms of tobacco and tobacco products including, cured and uncured leaves, which include as additives one or more cannabinoids as health enhancing, harm reduction, and/or experience enhancing agents.
- The present invention relates generally to software, and more particularly, to a patient information synchronization system.
- A picture archiving and communication system (PACS) is a medical imaging technology that provides economical storage and convenient access to images from multiple source machines. Electronic images and reports are transmitted digitally via PACS, which eliminates the need to manually file, retrieve, or transport physical film jackets. The universal format for PACS image storage and transfer is known as digital imaging and communications in medicine (DICOM). Non-image data, such as documents, may be incorporated using standard document formats such as portable document format (PDF) which are encapsulated in DICOM. A PACS system provides archives for storage of multi-modality images, integrates images with patient database information, facilitates laser printing of images, and displays both images and patient information at work stations throughout the network and at remote locations.
- A vendor neutral archive (VNA) is a medical imaging technology in which images and documents are archived in a standard format with a standard interface, such that they can be accessed in a vendor-neutral manner by other systems. A VNA system provides similar functionality as a PACS system without the vendor-specific applicability, namely radiology, though further incorporates storage of non-DICOM content and access protocols. One such type of non-DICOM content is known as health level-7 (HL7), which is a set of international standards for the transfer of clinical and administrative data between software applications used by various healthcare providers.
- Imaging Object Change Management (IOCM) specifies how one actor communicates local changes applied on existing imaging objects to other actors that manage copies of the modified imaging objects in their own local systems. The supported changes include object
- Various attempts have been made to address cigarette health problems through reformulation of cigarettes. For example, special blends of tobacco have been formulated for cigarettes with reduced levels of tar and nicotine. Unfortunately, each reduction of the tar and nicotine level has been accompanied by a corresponding reduced level of user satisfaction requiring unhealthy longer, stronger puffs to increase smoker's satisfaction. As such, sales of lowered tar and nicotine cigarettes, particularly those commercially classified as “ultra low tar and nicotine”, have not lived up to expectations. More recently, efforts have been made to altogether remove additives from cigarettes. While such “additive free” cigarettes may provide a purer tobacco smoke, it is unclear whether they provide any corresponding health benefits. In fact, in some cases, they have been shown to be stronger in tar and nicotine since they contain relatively more tobacco than non-additive containing cigarettes.
- As specified in the Background Section above, there is a need in the art to develop new tobacco additives to reduce the harm associated with tobacco use and improve user experience with tobacco.
- Thus According to a first aspect of the present invention there is provided an effective technique for adding cannabinoids to cigarettes, cigars, bulk tobacco (including leaves), reconstituted tobacco, pipe tobacco and smokeless snuff, “moist snuff” or “chewing” tobacco (as smokeless tobacco is commonly known) as well as to non-tobacco smokable and mouthable products. In an embodiment the cannabinoid added to the tobacco is (tetrahydrocannbinol) THC. In another embodiment, the cannabinoid is cannabidiol (CBD). In another embodiment the cannabinoid is selected from the group consisting of tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV). In another embodiment the cannabinoid is a combination of two or more of the cannabinoids listed herein.
- According to a second aspect the invention there is provided a tobacco product selected from the group consisting of cigarettes, cigars, bulk tobacco (including leaves), reconstituted tobacco, pipe tobacco and smokeless snuff or “chewing” tobacco (as smokeless tobacco is commonly known) as well as to non-tobacco smokable and mouthable products, further comprising the addition of one or more cannabinoids selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- According to a third aspect of the invention there is provided a method for reducing the harm associated with tobacco use in a subject in need thereof comprising the steps of providing to that user a tobacco product further comprising the addition of one or more cannabinoids selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- Preferred features of the invention will now be described in further detail. Features described as being preferred in relation to one aspect of the invention apply mutatis mutandis to all other aspects, unless clearly stated otherwise.
- The cannabinoids used may be isolated using any methods known by those having skill in the art, including the use of hydrocarbon solvents and solventless extraction. Therefore in one embodiment the cannabinoids used as additives are produced by extraction of cannabis plant material with supercritical or subcritical CO2. In an alternative embodiment the cannabinoid additives are produced by extraction from plant material by volatilisation with a heated gas. In an alternative embodiment the cannabinoid additives are produced from plant material through the sequential processes of CO2 extraction followed by fractional distillation. In some embodiments, the cannabinoid additives contain all of the naturally occurring cannabinoids in the plant material. Alternatively, synthetic or highly purified isolates of the cannabinoids can be used.
- The term “approximately equal” is used to refer to ratios of cannabinoids which are in the range of between 0.9:1 to 1:0.9 (THC: CBD). Additionally the term “1:1” is taken herein to refer to approximately equal amounts of cannabinoids .
- These and other systems, methods, objects, features, and advantages of the present disclosure will be apparent to those skilled in the art from the following detailed description of the embodiments and drawings.
- All documents mentioned herein are hereby incorporated in their entirety by reference. References to items in the singular should be understood to include items in the plural, and vise versa, unless explicitly stated otherwise or clear from the text. Grammatical conjunctions are intended to express any and all disjunctive and conjunctive combinations of conjoined clauses, sentences, words, and the like, unless otherwise stated or clear from context
- The cannabinoids are a class of molecules primarily obtained through the extraction of cannabis plant material. The various cannabinoids include tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV) as well as others. Various cannabinoids, used alone or in combination have shown a variety of significant biological effects including but not limited to pain relief, anti cancer, anti inflammatory, anti emetic, anti convulsant, and several others.
- With respect to cannabinoid additives for tobacco, CBD is particularly useful due to its non-intoxicating, antineoplastic, anti-inflammatory, and pain relieving effects. While specific embodiments of tobacco products including cannabinoids are discussed with respect to CBD, it is noted that other cannabinoids may be added to or substituted depending on the specific effects desired from the additives. Therefore, in an embodiment, a substantially pure, dry powder of CBD is mixed directly with the tobacco used in smokable or smokeless tobacco during the manufacturing process and/or directly into smokable or smokeless tobacco products. CBD can also be inserted or mixed into mixtures of lamina tobaccos, reconstituted tobacco and lamina tobacco mixed with reconstituted tobacco as well as into a cigarette filter, holder, paper or wrapper. One may also place the additive in tobacco prior to curing so long as it will remain stable enough to sustain its benefits all the way through processing and in storage. Other forms of cannabinoid additives, namely oils can be used in the present invention. Oils may be particularly useful do the fact that it is difficult to get substantially pure, solid forms of many cannabinoids. Oils may be particularly useful in chewing tobacco, and as a coating for the interior surface of cigarette and cigar wrappers. Other formulations of cannabinoids may be incorporated into tobacco products such as microencapsulated, particleized cannabinoids.
- Cannabinoids can be incorporated into a tobacco or non tobacco product in a number of different ways including being directly mixed with the tobacco or inserted into a cigarette/cigar filter, holder, or wrapper either in a dry, oil, or microencapsulated form. In an embodiment of the present invention, a substantially pure, “dry” form of CBD can be blended into, sprayed or dusted onto the full or cut tobacco or non-tobacco leaves during the curing or manufacturing process. In that way, the substantially pure, “dry” form of CBD will already be incorporated onto the tobacco when it is rolled into the cigarette packaged in a bulk smokeless container. While the quantity of CBD to be used in this process can vary, it is expected that between 0.1 and 5000 milligrams of CBD or other cannabinoid would be a suitable amount for a cigarette or smokeless tobacco wad containing 400-1200 milligrams of tobacco, with a more preferred amount of CBD or other cannabinoid to be between 0.1% to 20.0% by weight of tobacco or 0.4 milligrams to 240 milligrams for a cigarette or smokeless tobacco wad containing 400-1200 milligram of tobacco. In some embodiments the cannabinoids are added by adding an amount of a whole plant cannabis extract.
- In another embodiment the tobacco and cannabinoid additives are provided as a kit comprising separate portions of tobacco and cannabinoid extracts, enabling users to combine the tobacco and cannabinoid additives in proportions of their choosing.
- In another embodiment, the cannabinoid(s) are incorporated into the cigarette filter either as dispersed particles, liquid infused into the filter medium or microencapsulated particles. The cannabinoid(s) may also be incorporated into tobacco paper, plug wrap, and or filter paper.
- In other embodiments, the cannabinoid(s) are added to the tobacco after the tobacco has been dried, cured and otherwise processed to be ready for formulation into cigarettes, smokeless and other forms. The addition of cannabinoids at this stage is beneficial as it avoids the possibility of degradation of the cannabinoids over time and during the processing steps of the raw tobacco leaves. It also has the added benefit of enabling a more accurate and precise dosage of cannabinoid(s).
- In some embodiments terpenes, either alone or in combination with cannabinoids are added as additives to the tobacco products.
- In some embodiments the cannabinoids present as additives are THC and CBD present in ratios in the range of 1:100 to 100:1, particularly between 1:20 to 20:1. In some embodiments the cannabinoids present are THC and CBD in a 1:1 ratio.
- There are several benefits associated with cannabinoid additives to tobacco products, especially as a harm reduction measure. One benefit is the reduced irritation associated with tobacco product use. In particular, the addition of CBD, with its known anti inflammatory and pain relieving properties is particularly beneficial in reducing some of the discomfort associated with tobacco use. The use of THC as an additive to tobacco products is beneficial, especially in states where the recreational use of cannabis is permitted and as a way to reduce the nausea that sometimes accompanies tobacco use.
- The use of cannabinoids as tobacco additives, may be particularly useful as a mechanism to reduce the carcinogenicity associated with tobacco products. Substantial evidence has been presented that these compounds can reduce tumor growth in animal models of cancer. A large body of scientific evidences strongly support THC and other cannabinoid agonists exert anticancer actions in preclinical models of cancer (including immunocompetent mice) through a well-established mechanism of action. See ie The Use of Cannabinoids as Anticancer Agents—Velasco et al. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Jan. 4 2016, which is hereby incorporated by reference in its entirety.
- The use of cannabinoids as tobacco additives, may be particularly useful as a mechanism to reduce the inflammatory response often caused by the use of tobacco products. Tobacco use is known to cause various inflammatory responses including but not limited to inflammation and irritation of the mouth and throat. Various cannabinoids are known to have an anti-inflammatory effect. See ie Comparative topical anti-inflammatory activity of cannabinoids and cannbivarins—Tubaro et al. Fitoterapia, (2010) 816-819, which is hereby incorporated by reference in its entirety.
- Therefore, In one embodiment, the invention is a smokable or non smokable composition comprising tobacco and at least one additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- Another embodiment is, method of reducing the harm associated with tobacco use comprising providing tobacco users with tobacco products to which have been added at least one cannabinoid selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV). In some cases the harm associated with tobacco use that is to be reduced is the inflammation that is associated with tobacco use. In some cases the harm associated with tobacco use that is to be reduced is the carcinogenicity of tobacco. In some cases the harm associated with tobacco used that is to be reduced is the mouth discomfort associated with the use of smokeless tobacco.
- Another embodiment is a tobacco mixture with a reduced carcinogenicity profile comprising tobacco with a cannabinoid additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- Another embodiment is method for reducing free radical damage to the oro-pharyngeal cavity, respiratory tract and lungs from tobacco smoke, the method comprising adding a cannabinoid additive to tobacco products, the additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- Another embodiment is a cigarette comprising a paper wrapper surrounding a charge of tobacco, said cigarette further comprising a composition for reducing free radical damage to the oro-pharyngeal cavity, respiratory tract and lungs from tobacco smoke generated by said cigarette, said composition comprising a cannabinoid additive to tobacco products, the additive selected from the group consisting of tetrahydrocannabinol (THC), cannabidiol (CBD), tetrahydrocannabinolic acid (THCA), Cannabidiolic acid (CBDA), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), tetrahydrocannabivarin (THCV), and cannabidivarin (CBDV).
- While the present disclosure includes many embodiments shown and described in detail, various modifications and improvements thereon will become readily apparent to those skilled in the art. Accordingly, the spirit and scope of the present invention is not to be limited by the foregoing examples, but is to be understood in the broadest sense allowable by law.
- With respect to the above, it is to be understood that the invention is not limited in its application to the details of construction and to the arrangement of the components listed or the steps set forth in the description or illustrated in the drawings. The various apparatus and methods of the disclosed invention are capable of other embodiments, and of being practiced and carried out in various ways that would be readily known to those skilled in the art, given the present disclosure. Further, the terms and phrases used herein are for descriptive purposes and should not be construed as in any way limiting.
- As such, those skilled in the art will appreciate that the conception upon which this disclosure is based may be utilized as a basis for designing other inventions with similar properties. It is important therefore that the embodiments, objects, and claims herein, be regarded as including such equivalent construction and methodology insofar as they do not depart from the spirit and scope of the present invention.
Claims (20)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/921,231 US20200330537A1 (en) | 2016-03-06 | 2020-07-06 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662304276P | 2016-03-06 | 2016-03-06 | |
US15/451,377 US10369178B2 (en) | 2016-03-06 | 2017-03-06 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
US16/510,479 US10702565B2 (en) | 2016-03-06 | 2019-07-12 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
US16/921,231 US20200330537A1 (en) | 2016-03-06 | 2020-07-06 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US16/510,479 Continuation US10702565B2 (en) | 2016-03-06 | 2019-07-12 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
Publications (1)
Publication Number | Publication Date |
---|---|
US20200330537A1 true US20200330537A1 (en) | 2020-10-22 |
Family
ID=65014675
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/451,377 Active US10369178B2 (en) | 2016-03-06 | 2017-03-06 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
US16/510,479 Active US10702565B2 (en) | 2016-03-06 | 2019-07-12 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
US16/921,231 Pending US20200330537A1 (en) | 2016-03-06 | 2020-07-06 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/451,377 Active US10369178B2 (en) | 2016-03-06 | 2017-03-06 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
US16/510,479 Active US10702565B2 (en) | 2016-03-06 | 2019-07-12 | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use |
Country Status (1)
Country | Link |
---|---|
US (3) | US10369178B2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10383358B2 (en) * | 2017-06-14 | 2019-08-20 | Digital Rarity Llc | Cannabinoid containing cannabis extract infused into rolling paper |
US11950623B2 (en) | 2017-09-15 | 2024-04-09 | Big 5 Properties Inc. | Plant product infused with oil and method of infusion |
US10897925B2 (en) | 2018-07-27 | 2021-01-26 | Joseph Pandolfino | Articles and formulations for smoking products and vaporizers |
US20200035118A1 (en) | 2018-07-27 | 2020-01-30 | Joseph Pandolfino | Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes |
WO2020070184A1 (en) * | 2018-10-03 | 2020-04-09 | Nerudia Limited | Smoking substitute consumable |
EP3698653A1 (en) * | 2019-02-22 | 2020-08-26 | Nerudia Limited | Smoking substitute consumable |
CN114269168B (en) * | 2019-02-11 | 2023-06-23 | 斯瓦蒙卢森堡公司 | Reconstituted cocoa material for aerosol generation |
AU2020223091A1 (en) | 2019-02-11 | 2021-08-19 | Swm Luxembourg | Cannabis wrapper for smoking articles |
AU2020221787A1 (en) | 2019-02-11 | 2021-08-26 | Swm Luxembourg | Reconstituted cannabis material for generating aerosols |
AU2020221789A1 (en) | 2019-02-11 | 2021-08-19 | Swm Luxembourg | Filler containing blends of aerosol generating materials |
CA3129116A1 (en) * | 2019-02-11 | 2020-08-20 | Swm Luxembourg | Cocoa wrapper for smoking articles |
EP3753555A1 (en) * | 2019-06-19 | 2020-12-23 | Universität Basel | Composition for inhalation comprising cannabidiol for the treatment of mental disorder and/or drug addiction and/or sleep disorder and/or pain |
EP3753556A1 (en) * | 2019-06-19 | 2020-12-23 | Universität Basel | Composition and smokable product comprising cannabidiol for use in the treatment of mental disorder and/or drug addiction and/or sleep disorder and/or pain |
US11253564B2 (en) | 2019-09-06 | 2022-02-22 | Perfect Herbal Blends, Inc. | Optimizing volatile entourages in dry flowering plant mixtures |
ES2956536T3 (en) | 2019-09-12 | 2023-12-22 | Cabbacis Llc | Articles and formulations for smoking and vaporizer products |
EP3912485A1 (en) * | 2020-05-18 | 2021-11-24 | Del-Vis Sp. z o.o. | Cigarette product and a method for manufacturing the product |
WO2023184618A1 (en) * | 2022-03-31 | 2023-10-05 | 昆明百泓健康产业有限公司 | Cigarette insertion strip and preparation method therefor |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016030369A1 (en) * | 2014-08-25 | 2016-03-03 | Janing Holding Aps | Device with compositions for delivery to the lungs, the oral mucosa and the brain |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2015360349B2 (en) * | 2014-12-12 | 2020-10-08 | Ojai Energetics Pbc | Microencapsulated cannabinoid compositions |
-
2017
- 2017-03-06 US US15/451,377 patent/US10369178B2/en active Active
-
2019
- 2019-07-12 US US16/510,479 patent/US10702565B2/en active Active
-
2020
- 2020-07-06 US US16/921,231 patent/US20200330537A1/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016030369A1 (en) * | 2014-08-25 | 2016-03-03 | Janing Holding Aps | Device with compositions for delivery to the lungs, the oral mucosa and the brain |
Non-Patent Citations (1)
Title |
---|
Sumner et al. Harvesting and curing flue cured tobacco, 2009. * |
Also Published As
Publication number | Publication date |
---|---|
US20190022158A1 (en) | 2019-01-24 |
US20190328807A1 (en) | 2019-10-31 |
US10369178B2 (en) | 2019-08-06 |
US10702565B2 (en) | 2020-07-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20200330537A1 (en) | Tobacco products with cannabinoid additives and methods for reducing the harm associated with tobacco use | |
Bhaskar et al. | Consensus recommendations on dosing and administration of medical cannabis to treat chronic pain: results of a modified Delphi process | |
Raina et al. | Chemopreventive effects of oral gallic acid feeding on tumor growth and progression in TRAMP mice | |
Tofighi et al. | Internet highs—seizures after consumption of synthetic cannabinoids purchased online | |
US20150150303A1 (en) | Electronic cigarette liquid and method of use to reduce, replace, or eliminate nicotine intake/addiction | |
Shao et al. | Pod-mod vs. conventional e-cigarettes: nicotine chemistry, pH, and health effects | |
Omaiye et al. | Flavour chemicals, synthetic coolants and pulegone in popular mint-flavoured and menthol-flavoured e-cigarettes | |
Tao et al. | Estradiol signaling mediates gender difference in visceral adiposity via autophagy | |
Guo et al. | Major constituents of cannabis vape oil liquid, vapor and aerosol in California vape oil cartridge samples | |
AU2019370810B2 (en) | Aerosolised formulation | |
Benowitz et al. | The role of compensation in nicotine reduction | |
Ali et al. | Histopathological changes in oral mucosa due to takhzeen al‐qat: a study of 70 biopsies | |
Ferreira et al. | Efficacy of Hesperozygis ringens essential oil as an anesthetic and for sedation of juvenile tambaqui (Colossoma macropomum) during simulated transport | |
US20170188616A1 (en) | Cannabinoid-enriched supplement | |
Greenway et al. | Medical marijuana—an obesity problem or opportunity? | |
Solecki et al. | Clearing the air: adolescent smoking trends | |
Hindelang et al. | Using the BMD approach to derive acceptable daily intakes of cannabidiol (CBD) and tetrahydrocannabinol (THC) relevant to electronic cigarette liquids | |
US20210000166A1 (en) | Cannabinoid depleted cannabis formulations and products | |
Mallock-Ohnesorg et al. | Oral nicotine pouches with an aftertaste? Part 1: screening and initial toxicological assessment of flavorings and other ingredients | |
Gutierrez et al. | Adult consequences of repeated nicotine and Δ9-tetrahydrocannabinol (THC) vapor inhalation in adolescent rats | |
Back et al. | Harmful and potentially harmful constituents (HPHCs) in two novel nicotine pouch products in comparison with regular smokeless tobacco products and pharmaceutical nicotine replacement therapy products (NRTs) | |
Kar et al. | Effect of electronic cigarettes on the inner mucosa of the craniofacial region | |
Stockburger | Forms of administration of cannabis and their efficacy. | |
Vishal Rao et al. | The E‐cigarette ban in India—A step in the right direction? | |
Glick et al. | Allergic contact dermatitis from cigarettes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
AS | Assignment |
Owner name: CHICAGO ATLANTIC ADMIN, LLC, ILLINOIS Free format text: SECURITY INTEREST;ASSIGNOR:VIREO HEALTH INTERNATIONAL, INC.;REEL/FRAME:055721/0544 Effective date: 20210325 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
AS | Assignment |
Owner name: RESURGENT BIOSCIENCES, INC, MINNESOTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GREENBAUM, ERIC;KINGSLEY, KYLE;SIGNING DATES FROM 20230125 TO 20230221;REEL/FRAME:062893/0261 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |