US20200206481A1 - Methods for delivery of therapeutic materials to treat cancer - Google Patents
Methods for delivery of therapeutic materials to treat cancer Download PDFInfo
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- US20200206481A1 US20200206481A1 US16/685,950 US201916685950A US2020206481A1 US 20200206481 A1 US20200206481 A1 US 20200206481A1 US 201916685950 A US201916685950 A US 201916685950A US 2020206481 A1 US2020206481 A1 US 2020206481A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1011—Multiple balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
-
- A—HUMAN NECESSITIES
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- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1002—Balloon catheters characterised by balloon shape
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
- A61B17/12045—Type of occlusion temporary occlusion double occlusion, e.g. during anastomosis
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M2025/0004—Catheters; Hollow probes having two or more concentrically arranged tubes for forming a concentric catheter system
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- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
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- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
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- A61M25/00—Catheters; Hollow probes
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
Definitions
- the embodiments described herein relate generally to methods for delivering a therapeutic material to treat pancreatic cancer.
- Pancreatic cancer is considered an almost chemoresistant tumor.
- the ineffective result of systemic chemotherapy is at least in part due to an insufficient drug concentration within the tumor because of dose-limited toxicity in bone marrow and epithelial tissue.
- systemic chemotherapy is limited its effectiveness, localized therapy can be desirable for advanced pancreatic cancer patients.
- one such treatment can include local intra-arterial delivery of chemotherapy.
- Intra-arterial infusion allows higher drug concentration to reach the tumor, overcoming the problem of poor blood flow to tumor mass in comparison to healthy tissue.
- intra-arterial chemotherapy can also take advantage of the first pass effect of chemotherapeutics, generating higher-level drug concentrations at the tumor cell membrane and therefore, enhancing cellular drug uptake as compared to intravenous infusion.
- local delivery can reduce systemic side effects.
- pancreatic arterial infusion chemotherapy can range widely, for example, from 7% to 65%, at least in part due to efficacy of drug delivery where anticancer drugs were administered via the celiac artery without assessment of drug distribution.
- a need exists for improved methods for delivering a treatment such as a biologic agent and/or drug formation to target tissue of the pancreas, as well as hepatic tumors and cholangiocarinoma.
- a localized method for treatment of cancer comprising the steps of:
- the drug delivery catheter is a multi-occlusion balloon catheter.
- the multi-occlusion balloon catheter may comprise at least two balloons.
- the multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
- the therapeutic agent is selected from the group (5-fluorouracil (5-FU), Aldesleukin, Axitinib, Bleomycin, Carboplatin, Cetuximab, Cisplatin, Cyclophosphamide, dacarbazine, Doxorubicin Hydrochloride, doxorubicin liposomal non-pegylated (un-coated), doxorubicin liposomal pegylated (PEG coated), Floxuridine, Gemcitabine Hydrochloride, Irinotecan Hydrochloride Liposome, Lanreotide Acetate, leucovorin (antidote to folic acid antagonist used with 5FU), Methotrexate, Mitomycin, Mitoxantrone, Nivolumab, Olaparib, Oxaliplatin, Sorafenib Tosylate, Temsirolimus, Thiotepa, Topotecan Hydrochlor
- the navigating step includes navigating the catheter using ERCP.
- the navigating step includes navigating the catheter to the bile duct percutaneously.
- the localized method is used to treat pancreatic cancer.
- the localized method is used to treat at least one of hepatic tumors and cholangiocarinoma.
- FIG. 1 is an illustration of a pancreas and related structure in a human
- FIGS. 2 and 3 are schematic illustrations of a multi-occlusion catheter insertion device according to an embodiment, in a first configuration and a second configuration, respectively;
- FIG. 4 is a side view of a multi-occlusion catheter insertion device according to an embodiment, shown in a dilated configuration
- FIG. 5 is a side view of a portion of the multi-occlusion catheter insertion device of
- FIG. 4
- FIGS. 6-11 are each a cross-sectional view of a different portion of the multi-occlusion catheter insertion device of FIG. 4 , taken along lines 6 - 6 , 7 - 7 , 8 - 8 , 9 - 9 , 10 - 10 , and 11 - 11 , respectively, in FIG. 5 .
- FIG. 12 is a side view of a multi-occlusion catheter insertion device according to an embodiment.
- FIG. 13 is a side view of a portion of the multi-occlusion catheter insertion device of FIG. 12 .
- FIGS. 14-19 are each a cross-sectional view of a different portion of the multi-occlusion catheter insertion device taken along lines 14 - 14 , 15 - 15 , 16 - 16 , 17 - 17 , 18 - 18 , and 19 - 19 , respectively, in FIG. 13 .
- FIG. 20 is a top view of a multi-occlusion catheter insertion device according to an embodiment, in a first configuration.
- FIG. 21 is a side view of a handle included in the multi-occlusion catheter insertion device of FIG. 20 .
- FIG. 22 is a top view of a handle included in the multi-occlusion catheter insertion device of FIG. 20 .
- FIG. 23 is an enlarged cross-sectional view of a portion of the handle of FIG. 21 , indicated by the region X 1 and taken along the line 23 - 23 in FIG. 22 .
- FIG. 24 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device of FIG. 20 , taken along the line 24 - 24 .
- FIG. 25 is an enlarged cross-sectional view of a portion of the handle of FIG. 21 , indicated by the region X 2 and taken along the line 25 - 25 in FIG. 22 .
- FIG. 26 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device of FIG. 20 , taken along the line 26 - 26 .
- FIG. 27 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device of FIG. 20 , taken along the line 27 - 27 .
- FIG. 28 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device of FIG. 20 , taken along the line 28 - 28 .
- FIG. 29 is a top view of the multi-occlusion catheter insertion device of FIG. 20 in a second configuration.
- FIG. 30 is an illustration of a portion of the multi-occlusion catheter insertion device of
- FIG. 20 in use within a portion of a body.
- FIG. 31 is a flowchart illustrating a method for treating the pancreas, according to an embodiment.
- Methods described herein can be used, for example, for the insertion and manipulation of a multi-occlusion catheter device to deliver a therapeutic agents to the bile duct for treatment of pancreatic cancer or other localized cancer.
- Tumors localized around the bile duct may benefit from localized delivery through the bile duct itself.
- the bile duct can be exogenously accessed through an endoscopic retrograde cholangiopancreatogram (ERCP) catheter, one can envision delivery of a double balloon catheter into the bile duct using established ERCP technique.
- ERCP endoscopic retrograde cholangiopancreatogram
- chemotherapeutic elements are then infused between the two balloons.
- the chemotherapeutic agent will then diffuse out the wall of the bile duct and into the tissue.
- a therapeutic material for treatment of pancreatic cancer or other localized cancer is delivered into the bile duct using the multi-occlusion catheter.
- the gall bladder is connected to the pancreas via the common bile duct.
- Localized delivery to the site of the tumor has advantages for both maximizing local drug concentration at the tumor site, and decreasing systemic side effects/toxicity.
- the approach disclosed herein may avoid some of the toxicity related side effects of delivering chemotherapy drugs directly to the pancreas and may enable the use of more concentrated dosage of chemotherapy drugs.
- therapeutic particles may be substituted for or used in conjunction with chemotherapy drugs.
- it may be useful to place a stent to open the bile duct prior to delivering the chemotherapy and/or therapeutic agent.
- such a use can include navigating a catheter such as a multi-occlusion catheter to the target anatomy using conventional percutaneous approaches or the same approach used for endoscopic retrograde cholangiopancreatogram (ERCP), isolating the bile duct, and then exogenously introducing therapeutic cells/agents/biologics into the isolated area, via an infusion port of the catheter.
- the cells/agents biologics can be delivered to the bile duct with high efficiency.
- a device with two sliding balloon catheters can be used to isolate bile duct. The isolated area can then be perfused with cells/therapeutic agents via an infusion port disposed between the two balloon catheters.
- the devices described herein can be arranged such that a user can manipulate a portion of the device substantially single handedly, to allow for accurate delivery of a biological agent and/or drug formulation to an isolated segment or portion of an organ.
- an apparatus in some embodiments, includes a handle, an inner catheter, an outer catheter, an actuator, a first occlusion element, and a second occlusion element.
- the inner catheter is coupled to the handle and the first occlusion element is coupled to the inner catheter.
- the inner catheter defines an inner catheter lumen that is configured to receive a guidewire.
- the outer catheter is coupled to the housing and the second occlusion element is coupled to the outer catheter.
- the outer catheter defines a first lumen that is in fluid communication with a distal opening and is configured to introduce a therapeutic agent through the distal opening into the bile duct.
- the outer catheter defines a second lumen that is configured to receive at least a portion of the inner catheter.
- the actuator is coupled to the handle and is configured to move the outer catheter relative to the handle.
- the second occlusion element is disposed proximal to the first occlusion element and a distance therebetween is adjustable when the outer catheter is moved relative to the handle by the actuator.
- an apparatus in some embodiments, includes a handle, an inner catheter, an outer catheter, a first occlusion element, a second occlusion element, and an actuator.
- the inner catheter is coupled to the handle and the first occlusion element is coupled to the inner catheter.
- the outer catheter is coupled to the housing and the second occlusion member is coupled to the outer catheter.
- the outer catheter defines a first lumen that is in fluid communication with a distal opening and that is configured to introduce a therapeutic agent therethrough and into the bile duct.
- the outer catheter defines a second lumen that is configured to receive at least a portion of the inner catheter.
- the second occlusion element is disposed proximal of the first occlusion element.
- the actuator is coupled to the handle and is configured to move the outer catheter relative to the handle between a first position in which the second occlusion element is at a first distance from the first occlusion element and a second position in which the second occlusion element is at a second distance from the first occlusion element, with the second distance being greater than the first distance.
- a system and/or device(s) is provided for endovascular introduction of therapeutic materials selectively to the bile duct for the treatment of pancreatic cancer.
- a device and/or system can include, for example, an inner catheter having a distal retractable occlusion element and an inner catheter lumen adapted and configured to introduce a guidewire, and an outer catheter having a distal retractable occlusion element, an infusion lumen adapted and configured to introduce therapeutic materials to the bile duct, and a lumen for slidably receiving the inner catheter.
- the distal retractable occlusion element of the outer catheter can be positioned proximal to the distal retractable occlusion element of the inner catheter; and a sealing element can be included that is configured to selectively isolate or seal an end of the outer catheter to prevent therapeutic materials from entering into the lumen of the outer catheter in which the inner catheter is slidably disposed.
- a selective sealing element can include, for example, a ring, a membrane, or any other suitable element configured to prevent loss of therapeutic material into the lumen of the outer catheter in which the inner catheter is disposed.
- the lumen provided in the inner catheter can be configured to perfuse a distal organ beyond the targeted isolation region of the artery.
- a distance between the proximal retractable occlusion element and the selective sealing element can be configured for external adjustment, thus allowing a user to customize the isolated area (between the two occlusion elements) to better target the bile duct during delivery of biologics.
- the proximal retractable occlusion element and the selective sealing element can have a cross-sectional diameter, for example, between 2-12 mm.
- the devices and methods described herein can be used for isolating the perfusion area of the gall bladder for introduction of chemotherapy for treatment of pancreatic cancer, hepatic tumors and cholangiocarinoma or other therapeutic agents targeted to the pancreas.
- a member is intended to mean a single member or a combination of members
- a material is intended to mean one or more materials, or a combination thereof.
- the term “set” can refer to multiple features or a singular feature with multiple parts.
- the set of ports can refer to a single port or to multiple ports.
- proximal and distal refer to a direction closer to and away from, respectively, an operator of, for example, a medical device.
- the end of the medical device closest to the patient's body e.g., contacting the patient's body or disposed within the patient's body
- the distal end portion is the end that is located furthest from a point of reference, such as an origin or a point of attachment.
- the distal end portion would be the end farthest away from a user's hand.
- the proximal end portion thus, would be the position nearer to a point of reference such as an origin, i.e., the user's hand.
- Table 1 is a list of chemotherapy drugs which may be delivered to the bile duct according to the method of the present invention.
- FIG. 1 illustrates the liver 10 , the gall bladder 20 , and the pancreas 30 situated within an abdominal cavity (not shown) of a mammal (e.g., a human).
- the pancreas 30 is a gland organ which is part of the digestive and endocrine system of vertebrates.
- the pancreas 30 is both an endocrine gland producing hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme.
- the common bile duct leads from the gall bladder to the pancreas 30 .
- FIGS. 2 and 3 are schematic illustrations of a multi-occlusion catheter insertion device 100 useful for delivering therapeutic agents to the bile duct for treatment of pancreatic cancer.
- the multi-occlusion catheter insertion device 100 (also referred to herein as “device”) can be arranged to allow for substantially single handed use to, for example, isolate a segment of a bodily lumen such as the buke duct, thereby allowing a procedure to be performed within the isolated segment and/or allowing a targeted delivery of a biological or therapeutic agent.
- the device 100 includes a handle 110 , an actuator 150 , a first catheter 160 , and a second catheter 170 .
- the handle 110 can be any suitable shape, size, or configuration.
- the handle 110 can have a shape and size that are configured to enhance the ergonomics of the device 100 .
- the handle 110 can be grasped by a user to insert a portion of the first catheter 160 and a portion of the second catheter 170 into a bodily lumen of a patient and can be manipulated to move, inflate, deflate, adjust, and/or otherwise reconfigure the portion of the first catheter 160 and the portion of the second catheter 170 within the bodily lumen.
- the second catheter 170 can be moved relative to the first catheter 160 , or vice-versa, to adjust a distance between a first occlusion element 168 coupled to a distal end portion of the first catheter 160 and a second occlusion element 178 coupled to a distal end portion of the second catheter 170 .
- the device 100 can be used to isolate a segment of the bile duct within the space defined between the first occlusion element 168 and the second occlusion element 178 .
- a procedure can then be performed within the isolated segment such as for example, delivering a therapeutic agent to the isolated segment.
- the handle 110 has a proximal end portion 111 and a distal end portion 112 . As described in further detail herein, the handle 110 can be arranged to enclose, house, and/or be disposed about a portion of the first catheter 160 and the second catheter 170 . For example, the first catheter 160 and the second catheter 170 can each be coupled to the handle 110 .
- a first port 120 and a second port 125 are each disposed at the proximal end portion 111 of the handle 110 .
- the first port 120 and the second port 125 can each define a lumen (not shown in FIGS. 2 and 3 ).
- the first port 120 and the second port 125 can be formed monolithically or integrally with the first catheter 160 .
- the first port 120 and the second port 125 can be any suitable size, shape, or configuration.
- the first port 120 and the second port 125 can extend from the proximal end portion 111 of the housing 110 such that at least a portion of the first port 120 and the second port 125 is accessible outside of the handle 110 .
- the first port 120 and the second port 125 can each be physically and fluidically coupled to a device, mechanism, and/or the like, such as, for example, a source of an inflation medium as described in more detail below.
- the first port 120 and the second port 125 can each include a Luer-Lok® or the like that can physically and fluidically couple the first port 120 and/or the second port 125 to such a device.
- the first set of ports 128 can be in fluid communication with at least a portion of the first catheter 160 to place at least the portion of the first catheter 160 in fluid communication with a device (e.g., a source of an inflation medium) coupled to the handle 110 via the first port 120 and/or the second port 125 .
- the lumen of the first port 120 can be in fluid communication with a first lumen defined by the first catheter 160 and the lumen of the second port 125 can be in fluid communication with a second lumen defined by the first catheter 160 .
- the distal end portion 112 of the handle 110 includes a third port 130 , a fourth port 135 , and a fifth port 140 (collectively referred to herein as a second set of ports 143 ).
- the second set of ports 143 can be any suitable arrangement such as, for example, described above with reference to the first set of ports 128 .
- the third port 130 , the fourth port 135 , and the fifth port 140 can each define a lumen (not shown in FIGS. 2 and 3 ) and can each include a Luer-Lok® or the like that can physically and fluidically couple the third port 130 , the fourth port 135 , and/or the fifth port 140 to any suitable attachment, device, mechanism, and/or the like.
- the third port 130 , the fourth port 135 , and/or the fifth port 140 can each be coupled to an external device such as a device supplying a therapeutic agent, a device supplying an inflation medium or a device supplying an irrigation solution as described in more detail below with reference to, for example, device 400 .
- the second set of ports 143 includes the fifth port 140 and only one of the third port 130 and the second port 135 .
- the second set of ports 143 can be in fluid communication with at least a portion of the second catheter 170 to place at least the portion of the second catheter 170 in fluid communication with such external devices coupled to the handle 110 via the third port 130 , the fourth port 135 , and/or the fifth port 140 .
- the third port 130 and/or the fourth port 135 can be coupled to and in fluid communication with a first lumen defined by the second catheter 170
- the fifth port 140 can be coupled to and in fluid communication with a second lumen defined by the second catheter 170
- the third port 130 , the fourth port 135 , and/or the fifth port 140 can be monolithically or integrally formed with the second catheter 170 .
- the second set of ports 143 can be coupled to or operably coupled to the actuator 150 as described in more detail herein.
- the first catheter 160 (also referred to herein as “inner catheter”) and the second catheter 170 (also referred to herein as “outer catheter”) can be any suitable catheter device.
- the first catheter 160 and the second catheter 170 are multi-lumen catheters.
- the first catheter 160 has a proximal end portion 161 and a distal end portion 162 .
- the proximal end portion 161 of the first catheter 160 is disposed within a portion of the handle 110 . More specifically, the proximal end portion 161 of the first catheter 160 can be fixedly disposed within the portion of the handle 110 to place the first catheter 160 in fluid communication with one or more of the ports 120 and 125 of the first set of ports 128 .
- the first catheter 160 can define a first lumen that can be physically and fluidically coupled to the first port 120 and a second lumen that can be physically and fluidically coupled to the second port 125 .
- a first catheter can be coupled to the handle and can be operably coupled to a first port and a second port (e.g., ports 120 , 125 ) via an intervening structure such as, for example, flexible tubing or the like.
- the first port 120 can be placed in fluid communication with a first lumen (not shown in FIGS. 2 and 3 ) defined by the first catheter 160 , as described in further detail herein.
- the second port 125 can be placed in fluid communication with a second lumen (not shown in FIGS. 2 and 3 ) defined by the first catheter 160 .
- the second port 125 and the second lumen of the first catheter 160 can receive a guidewire or the like, as described in further detail herein.
- the distal end portion 162 of the first catheter 160 extends beyond a distal end portion of the handle 110 and includes the occlusion member 168 .
- the occlusion member 168 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a bodily lumen in which the occlusion member 168 is disposed.
- the occlusion member 168 can be an inflatable balloon or the like that can be transitioned between a collapsed (e.g., deflated) configuration and an expanded (e.g., inflated) configuration.
- the arrangement of the first catheter 160 and the handle 110 can be such that the first port 120 is in fluid communication with the occlusion member 168 .
- the first port 120 can be fluidically coupled to a device that can supply a pressurized fluid (e.g., air, inert gas, or liquid) to the occlusion member 168 to transition the occlusion member 168 between a collapsed configuration and an expanded configuration, as described in further detail herein.
- a pressurized fluid e.g., air, inert gas, or liquid
- the second catheter 170 of the device 100 has a proximal end portion 171 and a distal end portion 172 . As shown in FIGS. 2 and 3 , the second catheter 170 is movably disposed about a portion of the first catheter 160 . More specifically, the second catheter 170 can be, for example, a multi-lumen catheter and can be arranged such that the first catheter 160 is movably disposed within a first lumen (not shown in FIGS. 2 and 3 ) defined by the second catheter 170 . The proximal end portion 171 can be movably disposed within the handle 110 such that a portion of the second catheter 170 is in fluid communication with the second set of ports 143 .
- the second catheter 170 can be physically and fluidically coupled to the third port 130 and the fourth port 135 , and/or the fifth port 140 .
- the second catheter can be disposed within a handle and can be operably coupled to one or more ports via an intervening structure such as, for example, flexible tubing or the like.
- the third port 130 and/or the fourth port 135 can be placed in fluid communication with the second lumen (not shown in FIGS. 2 and 3 ) defined by the second catheter 170 , as described in further detail herein;
- the fifth port 140 can be placed in fluid communication with a third lumen (not shown in FIGS. 2 and 3 ) defined by the second catheter 170 , as described in further detail herein.
- the distal end portion 172 of the first catheter 170 extends beyond a distal end portion of the handle 110 and includes an occlusion member 178 .
- the occlusion member 178 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a lumen in which the occlusion member 178 is disposed.
- the occlusion member 178 can be substantially similar to the occlusion member 168 of the first catheter 160 .
- the arrangement of the second catheter 170 and the handle 110 can be such that the third port 130 and/or the fourth port 135 is in fluid communication with the occlusion member 178 .
- the third port 130 and/or the fourth port 135 can be fluidically coupled to a device that can supply a pressurized fluid (e.g., air, inert gas, or liquid) to the occlusion member 178 to transition the occlusion member 178 between a collapsed configuration and an expanded configuration, as described in further detail herein.
- a pressurized fluid e.g., air, inert gas, or liquid
- at least a portion of the occlusion member 178 can be selectively permeable to allow a biological agent to pass therethrough.
- the distal end portion 172 of the second catheter 170 can define one or more openings.
- the fifth port 140 can be fluidically coupled to a device that can supply irrigation, therapeutic material or agents, biological agents, and/or the like to a volume or region disposed between the occlusion member 168 of the first catheter 160 and the occlusion member 178 of the second catheter 170 .
- the actuator 150 of the device 100 can be operably coupled to the second set of ports 143 .
- the actuator 150 is included in and/or coupled to the handle 110 and arranged relative to the second set of ports 143 to be operably coupled thereto.
- the actuator 150 can be any suitable device, mechanism, assembly, etc. that is movable between a first position relative to the handle 110 , associated with the device 100 in the first configuration ( FIG. 2 ), and a second position relative to the handle 110 , associated with the device 100 in the second configuration ( FIG. 3 ).
- the actuator 150 can be operable in moving the second set of ports 143 between a first position relative to the handle 110 (e.g., the distal position) and a second position relative to the handle 110 (e.g., the proximal position), as indicated by the arrow AA in FIG. 3 .
- the actuator 150 can also move the second catheter 170 relative to the handle 110 and/or relative to the first catheter 160 as described in more detail below.
- the actuator 150 can be a push or pull slide that can move within a track (not shown in FIGS. 2 and 3 ) defined by the handle 110 .
- the actuator 150 can be coupled to an energy storage device (e.g., a spring, compressed gas, etc.) that is configured to move the actuator 150 .
- the actuator 150 can include a push button that allows a spring to transition from a compressed configuration towards an uncompressed configuration to move the actuator 150 relative to the handle 110 .
- a portion of the actuator 150 can be rotated to move the actuator 150 between its first position and its second position relative to the handle 110 .
- the movement of the actuator 150 can move the second catheter 170 relative to the handle 110 .
- the proximal end portion 171 of the second catheter 170 can be movably disposed within the handle 110 (as described above) such that when the actuator 150 is moved from its first position to its second position, the proximal end portion 171 of the second catheter 170 is moved from a first position relative to the handle 110 (e.g., FIG. 2 ) to a second position relative to the handle 110 (e.g., FIG. 3 ).
- the movement of the actuator 150 moves the second catheter 170 relative to the first catheter 160 .
- a first distance D 1 is defined between the occlusion member 168 of the first catheter 160 and the occlusion member 178 of the second catheter 170 . Therefore, with the first catheter 160 fixedly disposed within the handle 110 , the movement of the second catheter 170 in the proximal direction (e.g., the AA direction) increases the distance between the occlusion member 168 of the first catheter 160 and the occlusion member 178 of the second catheter 170 to a second distance D 2 , as shown in FIG. 3 .
- a guidewire (not shown) can be inserted into the second port 125 and through a lumen defined by the first catheter 160 .
- the guidewire can be advanced through a bodily lumen and the device 100 can be manipulated to advance the first catheter 160 along the guidewire to place the distal end portion 162 of the first catheter 160 and the distal end portion 172 of the second catheter 170 at a target location within the bodily lumen.
- the actuator 150 can be moved in the AA direction (e.g., the proximal direction) to define a desired distance between the occlusion member 168 of the first catheter 160 and the occlusion member 178 of the second catheter 170 , thereby placing the device 100 in the second configuration ( FIG.
- an inflation source can be coupled to the second port 125 of the first catheter 160 and the same inflation source or a second inflation source can be coupled to the third port 130 and/or the fourth port 135 of the second catheter 170 .
- the inflation source(s) can be used to inflate the occlusion members 168 and 178 .
- the occlusion members 168 and 178 can be transitioned from the collapsed (e.g., deflated) configuration to the expanded (e.g., inflated) configuration to substantially isolate a segment of the bodily lumen disposed therebetween.
- a biological or therapeutic agent can be delivered to the substantially isolated segment via the fourth port 135 .
- the biological or therapeutic agent can be delivered through the fourth port 135 into a lumen of the second catheter that is in fluid communication with the opening (see, e.g., opening 479 in FIG. 20 ) defined by the distal end portion 172 of the second catheter 170 .
- the substantially isolated segment can be irrigated by coupling an irrigation source to the fifth port 140 .
- the irrigation is delivered to the substantially isolated segment via the opening (described above) defined by the distal end portion 172 of the second catheter 170 .
- FIGS. 4-11 illustrate a dilation catheter 200 according to an embodiment.
- FIG. 4 is a side view of the dilation catheter device 200 (also referred to herein as “catheter device”).
- dilatation of two balloons is used to occlude a desired length of an artery such as, for example, the splenic artery 40 (see, e.g., FIG. 2 ).
- the catheter device 200 includes a first catheter 260 (also referred to herein as “inner catheter”) and a second catheter 270 (also referred to herein as “outer catheter”), a first Y-adaptor 228 (also referred to herein as “first set of ports”) and a second Y-adaptor 243 (also referred to herein as “second set of ports”), a first occlusion element 268 (also referred to herein as “dilation element”, “occluder,” or “distal occlusion element”), and a second occlusion element 278 (also referred to herein as “dilation element”, “occluder,” or “proximal occlusion element”) each configured to occlude a portion of an artery.
- the first occlusion element 268 is coupled to the first catheter 260 and the second occlusion element 278 is coupled to the second catheter 270 .
- the occlusion elements 268 and 278 can each be moved between a collapsed configuration (also referred to as “retracted configuration”) for insertion of the catheter device 200 into a body of a patient (e.g., into an artery) and an expanded configuration (also referred to as “dilated configuration” or “inflated configuration”) for occluding a portion of an artery.
- the occlusion elements 268 and 278 when in the collapsed configuration have a smaller outer perimeter (or diameter) than when in the expanded configuration.
- the catheter device 200 includes a distal end portion 212 and a proximal end portion 211 .
- the occlusion elements 268 and 278 are expandable balloons coupled to an outer surface of the first catheter 260 and an outer surface of the second catheter 270 , respectively, and are disposed at the distal end portion 212 of the catheter device 200 .
- the catheter device 200 is shown in a dilated configuration in FIG. 4 with the occlusion elements 268 and 278 (i.e., balloons) in their expanded configuration (i.e., inflated, dilated).
- FIG. 5 is a side view of the distal end portion 212 of the catheter device 200 (e.g., a distal end portion of the first catheter 260 and the second catheter 270 ) and FIGS. 6-11 illustrate cross-sections at various locations along the distal end portion 212 of the catheter device 200 to illustrate the various lumens of the catheter device 200 .
- the first catheter 260 defines a first lumen 265 and a second lumen 263 that each can extend a length of the first catheter 260 .
- the first lumen 265 can be configured to receive a guidewire 280 (shown, for example, in FIG. 4 ).
- the second lumen 263 can be used to communicate an inflation medium to and from the first occlusion element 268 via an aperture 264 in fluid communication with the first occlusion element 268 (see, e.g., FIG. 10 ).
- the second catheter 270 defines a first lumen 274 , a second lumen 273 , and a third lumen 276 .
- the first lumen 274 can be used to communicate an inflation medium to and from the second occlusion element 278 via an aperture 275 in fluid communication with the second occlusion element 278 (see, e.g., FIG. 7 ).
- the second lumen 273 is configured to slidably receive at least a portion of the first catheter 260 therethrough, as shown in FIGS. 6-9 .
- the third lumen 276 can terminate and be in fluid communication with an infusion aperture 279 near a distal end 272 of the second catheter 270 (see, e.g., FIG. 8 ).
- the infusion aperture 279 can be used to communicate a cell/biological/therapeutic material to a desired location within a body/artery of a patient.
- the first Y-adaptor 228 is coupled to the first catheter 260 and includes two ports 220 and 225 , as shown in FIG. 4 .
- the port 220 defines a lumen (not shown) that is in fluid communication with the first lumen 263 of the catheter 260 and can be used to communicate an inflation medium to the first occlusion element 268 through the second lumen 263 .
- a source of an inflation medium can be coupled to the catheter device 200 via the port 220 of the first Y-adaptor 228 .
- the port 225 defines a lumen (not shown) that is in fluid communication with the second lumen 265 of the first catheter 260 (see, e.g., FIGS. 6-11 ) and can be used for introduction of the guidewire 280 into the second lumen 265 .
- the second Y-adapter 243 is coupled to the second catheter 270 and includes three ports 230 , 235 and 240 , as shown in FIG. 4 .
- the port 230 defines a lumen (not shown) that is in fluid communication with the second lumen 273 of the second catheter 270 (see, e.g., FIGS. 6-11 ) and can receive the first catheter 260 therethrough.
- the port 235 defines a lumen (not shown) that is in fluid communication with the first lumen 274 of the second catheter 270 and can be used to communicate an inflation medium to and from the second occlusion element 278 in a similar manner as described above for port 225 and lumen 263 .
- the port 240 defines a lumen (not shown) that is in fluid communication with the third lumen 276 of the second catheter 270 (see e.g., FIG. 6-11 ) and can be used to introduce cells/biological/therapeutic materials into and through the third lumen 276 and out through the infusion aperture 279 .
- the catheter device 200 can also include a seal element 285 (see, e.g., FIG. 9 ) (also referred to a as a “seal”, “sealing element”, “selective sealing element”, or “filter-ring”) disposed at or near a distal end 272 of the second catheter 270 .
- the seal element 285 can prevent the entry of cells and or biologics that have been injected into an artery from flowing back into the lumen 273 . By doing so, a maximum number of cells can be delivered to the treatment area, and improve engraftment efficiency.
- the seal element 285 can be for example, a ring, a membrane or other known sealing elements used in medical devices.
- the slidable coupling of the first catheter 260 within the second lumen 273 of the second catheter 270 allows a collective length of the first catheter 260 and the second catheter 270 to be adjusted by slidably moving the first catheter 260 and the second catheter 270 relative to each other. Because the first occlusion element 268 is coupled to the first catheter 260 and the second occlusion element 278 is coupled to the second catheter 270 , the slidable adjustment of the first catheter 260 and the second catheter 270 can thus allow adjustment of a distance between the second occlusion element 278 and the first occlusion element 268 .
- the second lumen 273 of the second catheter 270 can be sized to receive the first catheter 260 with sufficient clearance to allow for ease of sliding/adjustment.
- the catheter device 200 can be placed at a desired location within an artery, such as for example, within a splenic artery 40 (see e.g., FIG. 1 ) and used to infuse a cell/biological material to a pancreas 30 .
- a length of the first catheter 260 and the second catheter 270 can be adjusted such that a selected portion (e.g., a pancreatic portion) of the splenic artery 40 is isolated between the first occlusion element 268 and the second occlusion element 278 .
- a cell/biologic material can be injected through the catheter device 200 and into the isolated region of the splenic artery 40 .
- the infusion of a cell/biological agent can occur in the localized region surrounding the isolated region or segment of vessel 40 .
- the presence of one or more additional, side-branching vessels forming a flow-restricting configuration in the isolated region of vessel 40 can allow infusion to occur in a larger semi-localized region.
- the first catheter 260 can be configured such that it is slidably associated with the second catheter 270 and the space between (e.g., distance between) occlusion elements 268 and 278 can be varied according to the circumstances of the desired treatment.
- the positioning of the distal occlusion element 268 within an artery can be individualized based on the specific anatomy to allow an enclosed or isolated area between the two occlusion elements 268 and 278 with a linear length ranging, for example, from 3 cm to 22 cm.
- the cells targeted to the pancreas 30 can be infused through infusion port 240 , traverse through the third lumen 276 , and exit through the infusion aperture 279 into the area isolated between the two occlusion elements 268 and 278 .
- the catheter device 200 can be configured to enable delivery of target cells, such as insulin producing beta cells, and autologous stem cells (mesenchymal, bone marrow, and others) to blood vessels in communication with the pancreas in situ.
- target cells such as insulin producing beta cells, and autologous stem cells (mesenchymal, bone marrow, and others)
- the infusion pressure in the isolated blood vessel region can be measured with pressure monitoring through the infusion lumen of the catheter (with a monometer (not shown) in line with infusion port 279 ).
- the pressure in the third lumen 276 can be based on the size of the cells being delivered, on the flow rate, the viscosity of the solution, and/or flow resistance of the third lumen 276 of second catheter 270 .
- the flow resistance of the catheter device 200 can in turn be determined based on, for example, the inner coating material, the size and the length of the third lumen 276 , the size of the third port 240 , and/or the size of the distal infusion aperture 279 .
- the catheter device 200 can allow for rapid infusion of cells (e.g., up to 2 milliliter per second (ml/sec)). In some applications, the rapid infusion of cells can enhance uptake and eventual engraftment.
- the infusion aperture 279 Smaller aperture size (e.g., the infusion aperture 279 ), lumen size (e.g., the third lumen 276 ), and increased flow resistance may cause “sludging” of cells, leading to poor intra-arterial flow and diminished uptake.
- the infusion aperture 279 and luminal design of the catheter device 200 can be configured to minimize risk of mechanical cell damage during the infusion process.
- FIG. 12 illustrates an embodiment of a catheter device 300 that uses two filter elements, instead of expandable balloons to occlude and isolate the area of interest for infusion of cells or chemotherapeutic agents, without inhibiting the flow of plasma through the isolated area.
- the filter elements can be formed with, for example, a medical mesh material.
- the size of the pores of the filter elements can be, for example, about 2 microns ( ⁇ m) or less in length, which can inhibit cells from passing through the filter element, but not impede serum/plasma and other components from passing through the filter element.
- the catheter device 300 can be used for the same or similar functions as described above for catheter device 200 .
- the catheter device 300 can be used for introduction of cells or other biologic or therapeutic material into a desired location within a patient's body, such as within a splenic artery.
- the catheter device 300 includes a first catheter 360 and a second catheter 370 that can be slidably coupled together as described above for catheter device 200 , a first Y-adaptor 328 (also referred to herein as “first set of ports”) coupled to the first catheter 360 , a second Y-adaptor 343 (also referred to herein as “second set of ports”) coupled to the second catheter 370 , a first occlusion element 368 (also referred to herein as “dilation element”, “occluder”, “distal occlusion element”) and a second occlusion element 378 (also referred to herein as “dilation element”, “occluder”, “proximal occlusion element”) to occlude a portion of an artery.
- the first occlusion element 368 is coupled to the first catheter 360 and the second occlusion element 378 is coupled to the second catheter 370 .
- the occlusion elements 368 and 378 are filter elements that can be moved between a collapsed configuration (also referred to as “retracted configuration” or “closed configuration”) for insertion of the catheter device 300 into a body of a patient (e.g., into an artery) and an expanded configuration (also referred to as “dilated configuration” or “open configuration”), as shown in FIG. 12 , for occluding a portion of an artery.
- the occlusion elements 368 and 378 when in the collapsed configuration have a smaller outer perimeter (or diameter) than when in the expanded configuration.
- the catheter device 300 includes a distal end portion 312 and a proximal end portion 311 .
- FIG. 13 is a side view of the distal end portion 312 of the catheter device 300 and FIGS. 14-19 illustrate cross-sections at various locations along the distal end portion 312 of the catheter device 300 .
- the first catheter 360 defines a first lumen 363 and a second lumen 365 that each can extend a length of the first catheter 360 .
- the first lumen 363 can be configured to receive a wire deployment device 382 that can be coupled to the filter element 368 and configured to move the filter element 368 from its expanded or open configuration and its collapsed or closed configuration.
- the second lumen 365 can be configured to receive a guidewire 380 (shown in FIG. 12 ).
- the second catheter 370 defines a first lumen 373 , a second lumen 374 , and a third lumen 376 .
- the first lumen 373 is configured to slidably receive at least a portion of the first catheter 360 therethrough.
- the second lumen 374 can be configured to receive a wire deployment device 381 .
- the wire deployment device 381 can be coupled to the filter element 378 and used to move the filter element 378 between its expanded or open configuration and its collapsed or closed configuration.
- the third lumen 376 can terminate and be in fluid communication with an infusion aperture 379 (see, e.g., FIG. 16 ) near a distal end 372 of the second catheter 370 .
- the infusion aperture 379 can be used to communicate, for example, a cell or cells (or other therapeutic or biologic material) to a desired location within a body of a patient.
- the first Y-adaptor 328 includes a port 320 and a port 325 as shown in FIG. 12 .
- the port 320 defines a lumen (not shown) that is in fluid communication with the first lumen 363 of the catheter 360 .
- the port 325 defines a lumen (not shown) that is in fluid communication with the second lumen 365 of the catheter 360 , and can be used for introduction of the guidewire 380 into the second lumen 365 .
- the second Y-adapter 343 includes three ports 330 , 335 and 340 , as shown in FIG. 12 .
- the port 330 defines a lumen (not shown) that is in fluid communication with the first lumen 373 of the second catheter 370 and can receive the first catheter 360 therethrough.
- the port 335 defines a lumen (not shown) that is in fluid communication with the second lumen 374 of the second catheter 370 , and the port 335 defines a lumen (not shown) that is in fluid communication with the third lumen 376 of the second catheter 370 .
- the filter elements 368 and 378 can each be shaped as a cone when in their expanded or open configurations as shown in FIGS. 12 and 13 .
- the filter elements 368 and 378 can each be sized when in their expanded or open configurations to meet the size of a particular vessel diameter in which the catheter device 300 is to be deployed. After infusion of cells or a therapeutic/biologic material through the catheter device 300 , the filter elements 368 and 378 can be collapsed to a smaller size for removal of the catheter device 300 from the patient.
- a diameter of the occlusion elements when expanded within an artery, such as, for example, the splenic artery 40 , can be adjustable to meet anatomical variations including a) individual variability in the size of the splenic artery 40 and b) end to end variation as the artery size can taper down between the two ends of the artery.
- the proximal occlusion element e.g., the balloon 278 and/or the filter element 378
- the proximal occlusion element can be sized (e.g., have an outer diameter or outer perimeter) between, for example, 3-12 mm and the distal occlusion element (e.g., the balloon 268 and/or the filter element 368 ) between, for example, 3-12 mm.
- the proximal occlusion element can be larger than the distal occlusion element, smaller than the distal occlusion element, or the same size as the distal occlusion element.
- the multi-occlusion catheter insertion device 400 (also referred to herein as “catheter device” or “device”) includes a handle 410 , an actuator 450 , a first catheter 460 (also referred to herein as “inner catheter”), and a second catheter 470 (also referred to herein as “outer catheter”) and can be movable between a first configuration and a second configuration.
- the device 400 can be grasped by a user (e.g., a doctor, physician, surgeon, technician, etc.) and manipulated substantially single handedly to insert a portion of the first catheter 460 and a portion of the second catheter 470 into a bodily lumen of a patient and to move, inflate, deflate, adjust, and/or otherwise reconfigure the portion of the first catheter 460 and the portion of the second catheter 470 within the bodily lumen.
- a user e.g., a doctor, physician, surgeon, technician, etc.
- the second catheter 470 can be moved relative to the first catheter 460 , and vice-versa, to adjust a distance between a first occlusion element 468 coupled to a distal end portion of the first catheter 460 and a second occlusion element 478 coupled to a distal end portion of the second catheter 470 .
- the device 400 can be used to isolate a segment of a bodily lumen within the space or region defined between the first occlusion element 468 and the second occlusion element 478 .
- a procedure can then be performed within the isolated segment such as, for example, delivering a cell or a therapeutic/biological agent to the isolated segment.
- the handle 410 of the device 400 can be any suitable shape, size, or configuration.
- the handle 410 can have a shape and size that can enhance the ergonomics of the device 400 .
- the handle 410 has a proximal end portion 411 , a distal end portion 412 , and a medial portion 413 that can be shaped in such a manner as to be easily gripped by a user (e.g., a doctor, physician, surgeon, technician, etc.).
- the handle 410 can include a grip section 417 (see, e.g., FIG.
- the grip section can be, for example, an insert, an over-mold, or the like that is formed from a relatively deformable material and that can have a relatively high coefficient of friction, thereby enhancing the ergonomics of the handle 410 .
- the proximal end portion 411 of the handle 410 includes a first port 420 and a second port 425 collectively referred to herein as a first set of ports 428 ).
- the first port 420 and the second port 425 can be any suitable size, shape, or configuration.
- the first port 420 and the second port 425 can be coupled together via any suitable method (e.g., an adhesive, ultrasonic welding, mechanical fastener, and/or the like).
- the first port 420 and the second port 425 can be monolithically formed.
- the first port 420 and the second port 425 can extend from the proximal end portion 411 of the handle 410 such that at least a portion of the first port 420 and the second port 425 is accessible, as shown in FIGS. 20 and 21 .
- the first set of ports 428 can be, for example, a first Y-adapter, substantially similar to the Y-adapter 228 and/or 328 .
- a first port and a second port can be, for example, substantially parallel in a stacked configuration.
- a handle can include a first port and a second port that are substantially coaxial and arranged in a substantially concentric configuration such that at least a portion of the first port is disposed within the second port, or vice versa.
- the first port 420 and the second port 425 can be physically and fluidically coupled to an exterior device, mechanism, and/or the like as described above, for example, with reference to insertion device 100 .
- the first port 420 and the second port 425 can each define a lumen (described in more detail below) in fluid communication with such a device.
- the first port 420 and the second port 425 can each include a Luer-Lok® and/or any other attachment mechanism that can physically and fluidically couple the first port 420 and/or the second port 425 to any suitable device either directly or indirectly (e.g., by an intervening structure such as a flexible tubing to the like).
- the first set of ports 428 can be physically and fluidically coupled to the first catheter 460 such that when an external device is coupled to the handle 410 via the first port 420 and/or the second port 425 , at least the portion of the first catheter 460 is placed in fluid communication with that external device via the first port 420 and/or the second port 425 .
- the first port 420 can be coupled to a device that can, for example, supply a pressurized fluid (e.g., an inert gas, air, saline, water, and/or any other suitable fluid in gaseous or liquid form) that can flow through the first port 420 to be delivered to a portion of the first catheter 460 , as described in further detail herein.
- a pressurized fluid e.g., an inert gas, air, saline, water, and/or any other suitable fluid in gaseous or liquid form
- the second port 425 can be coupled to a device that can advance a guidewire or the like through the second port 425 and into a portion of the first catheter 460 , as described in further detail herein.
- a guidewire or the like can be manually inserted through the second port 425 without the use of an external device.
- the distal end portion 412 of the handle 410 includes a third port 430 , a fourth port 435 , and a fifth port 440 (collectively referred to as a second set of ports 443 ).
- the second set of ports 443 includes the fifth port 440 and only one of the third port 430 and the second port 435 .
- the second set of ports 443 can be any suitable size, shape, or configuration as described above with reference to the first set of ports 428 .
- the second set of ports 443 can be, for example, monolithically and/or unitarily formed.
- the second set of ports 443 can be monolithically formed with the catheter 470 .
- the second set of ports 443 can be formed with and/or coupled to any suitable structure or component of the handle 410 such that the second set of ports 443 can be moved relative to the handle 410 as described in more detail below.
- the third port 430 , the fourth port 435 , and the fifth port 440 can each include a Luer-Lok® and/or any other attachment mechanism that can physically and fluidically couple the third port 430 , the fourth port 435 , and/or the fifth port 440 to any suitable attachment, device, mechanism, and/or the like.
- the second set of ports 443 can be physically and fluidically coupled to the second catheter 470 such that when an external device is coupled to the handle 410 via the third port 430 , the fourth port 435 , and/or the fifth port 440 , at least a portion of the second catheter 470 is placed in fluid communication with that external device.
- the third port 430 and/or the fourth port 435 can be coupled to a device that can supply a pressurized fluid (as described above) that can flow through the third port 430 and/or the fourth port 435 , respectively, to be delivered to a portion of the second catheter 470 , as described in further detail herein.
- the fifth port 440 is coupled to, for example, an infusion device that is configured to deliver a biological or therapeutic agent and/or other suitable drug formulation to a target tissue via the fifth port 440 and a portion of the second catheter 470 .
- the fifth port 440 can be coupled to, for example, an irrigation device that can deliver an irrigation fluid to, for example, an isolated segment of a bodily lumen via the fifth port 440 and a portion of the second catheter 470 .
- the fifth port 440 can be coupled to, for example, the infusion device configured to deliver the biological agent and/or other suitable drug formulation, as described in further detail herein.
- the handle 410 defines a first track 414 and a second track 416 .
- the first track 414 slidably receives a portion of the actuator 450 . More specifically, at least a portion of the actuator 450 can extend through the track 414 , thereby allowing a user to engage the actuator 450 .
- the track 414 can define a path along which the actuator 450 can be moved between a first position relative to the handle 410 and a second position relative to the handle 410 , as described in further detail herein.
- the second track 416 slidably receives a portion of the fifth port 440 . In this manner, the fifth port 440 can extend through the second track 416 to be accessed by a user.
- the second track 416 can define a path along which the fifth port 440 can be moved, as described in further detail herein.
- the arrangement of the first set of ports 428 , the second set of ports 443 , the first track 414 and the second track 416 can be arranged along a surface of the handle 410 in various orientations.
- the first track 414 is shown as being defined by a top surface of the handle 410 (see, e.g., FIG. 20 ) and the second track 416 as being defined by a side surface of the handle 410 (see, e.g., FIG. 21 )
- a first track configured to receive an actuator can be defined by a side surface of a handle and a second track configured to receive a fifth port can be defined by a top surface of the handle.
- first set of ports 428 and the second set of ports 443 are shown extending from the handle 410 in a specific orientation, the first set of ports 428 and/or the second set of ports 443 can be oriented in any suitable manner relative to a surface of the handle 410 .
- the actuator 450 of the device 400 is operably coupled to the second set of ports 443 .
- the actuator 450 is included in and/or coupled to the handle 410 and arranged relative to the second set of ports 443 to be operably coupled thereto.
- a handle can be arranged such that at least a portion of an actuator is monolithically formed with at least a portion of a second set of ports.
- an actuator is operably coupled to a second set of ports via an intervening structure or the like.
- the second set of ports 443 can be coupled to a shuttle or the like, which in turn, is coupled to an actuator.
- the actuator 450 can be any suitable device, mechanism, assembly, etc. that is movable between the first position relative to the handle 410 , associated with the device 400 in the first configuration ( FIGS. 20-22 ), and a second position relative to the handle 410 , associated with the device 400 in the second configuration ( FIG. 29 ).
- the actuator 450 can be a mechanism that can be pushed or pulled to slide within the first track 414 defined by the handle 410 between its first position and its second position. In some embodiments, the actuator 450 can be arranged to slide relatively smoothly within the track 414 when moved between its first position and its second position. In other embodiments, the handle 410 and/or the actuator 450 can include a set of ribs, teeth, detents, protrusions, etc. that are sequentially engaged as the actuator 450 is moved between its first position relative to the handle 410 and its second position relative to the handle 410 .
- a user can move the actuator 450 a desired distance that can be quantified by the actuator 450 and/or the handle 410 engaging a particular surface (e.g., a particular rib, tooth, detent, protrusion, etc.).
- the handle 410 and/or the actuator 450 can be arranged at a predetermined setting that can correspond to a predetermined distance (e.g., 2 cm, 3 cm, etc.) between an end portion of the first catheter 460 and an end portion of the second catheter 470 .
- the set of ribs, teeth, detents, protrusions, etc. included in the handle 410 and/or the actuator 450 can be associated with pre-defined settings and/or adjustments.
- a handle 410 can include a visual indicator such as a measuring scale or the like.
- the handle 410 can include indicia (e.g., lines, markings, tic marks, etc.) that represents a gradation of a length of travel associated with moving the actuator 450 between its first position relative to the handle 410 and its second position relative to the handle 410 .
- the markings can represent distances of, for example, a centimeter, half a centimeter, a millimeter, and/or the like.
- the visual indicator can substantially correspond with the ribs, teeth, detents, protrusions, etc. of the handle 410 and/or actuator 450 .
- the actuator 450 can be operably coupled to one or more energy storage device (e.g., a spring or the like) that can facilitate the movement of the actuator 450 .
- the actuator 450 can include a push button that can rearrange or reconfigure at least a portion of the actuator 450 to allow a spring to transition from a compressed configuration towards an uncompressed configuration to move the actuator 450 relative to the handle 410 .
- the actuator 450 can be operable in moving the second set of ports 443 between a first position relative to the handle 410 (e.g., a distal position) and a second position relative to the handle 410 (e.g., a proximal position).
- a first position relative to the handle 410 e.g., a distal position
- a second position relative to the handle 410 e.g., a proximal position
- the movement of the actuator 450 and the second set of ports 443 can move the second catheter 470 between a first position relative to the handle 410 and a second position relative to the handle 410 , as described in further detail herein.
- the first catheter 460 and the second catheter 470 can be any suitable catheter device.
- the first catheter 460 and the second catheter 470 are multi-lumen catheters.
- the first catheter 460 has a proximal end portion 461 (see, e.g., FIGS. 21, 23 and 29 ) and a distal end portion 462 (see, e.g., FIGS. 20 and 29 ), and defines a first lumen 463 and a second lumen 465 (see, e.g., FIGS. 24-28 ).
- the proximal end portion 461 of the first catheter 460 is disposed within a portion of the handle 410 .
- proximal end portion 461 of the first catheter 460 can be fixedly disposed within the portion of the handle 410 to place the first catheter 460 in fluid communication with the first set of ports 428 .
- the first catheter 460 can be physically and fluidically coupled to the first set of ports 428 .
- a device can include a first catheter that is monolithically formed with a first set of ports.
- the proximal end portion 461 of the first catheter 460 is arranged such that the first lumen 463 of the first catheter 460 is in fluid communication with a lumen 421 defined by the first port 420 and the second lumen 465 of the first catheter 460 is in fluid communication with a lumen 426 of the second port 425 , as shown in FIG. 23 . Therefore, an external device (e.g., a device that can supply a pressurized fluid, as described above) can be physically and fluidically coupled to the first port 420 to place the external device in fluid communication with the first lumen 463 of the first catheter 460 . Similarly, an external device including at least a guidewire (not shown) can be coupled to the second port 425 and can be manipulated to advance the guidewire through the second port 425 and into the second lumen 465 , as described in further detail herein.
- an external device e.g., a device that can supply a pressurized fluid, as described above
- an external device including at least a guidewire can
- the distal end portion 462 of the first catheter 460 extends beyond a distal end portion of the handle 410 and includes an occlusion member 468 .
- the occlusion member 468 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a body lumen (e.g., artery) in which the occlusion member 468 is disposed.
- the occlusion member 468 can be an inflatable balloon or the like that can be transitioned between a collapsed (e.g., deflated) configuration and an expanded (e.g., inflated) configuration.
- the arrangement of the first catheter 460 can be such that the first lumen 463 is in fluid communication with the occlusion member 468 .
- the distal end portion 462 of the first catheter 460 can define a channel 464 that places the first lumen 463 in fluid communication with the occlusion member 468 .
- a pressurized fluid e.g., air, inert gas, or liquid
- the pressurized fluid can be delivered to the occlusion member 468 via the lumen 421 of the first port 420 , the first lumen 463 of the first catheter 460 , and the channel 464 of the first catheter 460 .
- the pressurized fluid can transition the occlusion member 468 between a collapsed configuration (not shown) and an expanded configuration (see e.g., FIG. 20 ), as described in further detail herein.
- the second catheter 470 of the device 400 has a proximal end portion 471 (see, e.g., FIGS. 20-22 ) and a distal end portion 472 (see, e.g., FIGS. 20 and 29 ), and defines a first lumen 473 , a second lumen 474 , a third lumen 476 and an opening 479 (also referred to herein as “infusion aperture”) (as shown, for example, in FIGS. 25-28 ).
- the second catheter 470 is movably disposed about a portion of the first catheter 460 (see, e.g., FIGS. 21-23 ). More specifically, the second catheter 470 can be arranged such that the first catheter 460 is movably disposed within the first lumen 473 defined by the second catheter 470 , as shown, for example, in FIGS. 26-28 .
- a catheter insertion device can include a second catheter that can be movably disposed within a handle and can be operably coupled to one or more ports via an intervening structure such as, for example, flexible tubing or the like.
- a catheter insertion device can include a second catheter that is monolithically formed with a third port, a fourth port, and/or a fifth port.
- the second catheter 470 is arranged such that the first lumen 473 of the second catheter 470 movably receives the first catheter 460 , the second lumen 474 of the second catheter 470 is in fluid communication with a lumen 431 defined by the third port 430 and a lumen 436 defined by the fourth port 435 , and the third lumen 476 of the second catheter 470 is in fluid communication with a lumen 441 defined by the fifth port 440 , as shown in FIG. 25 .
- the distal end portion 472 of the first catheter 470 extends beyond a distal end portion of the handle 410 such that an occlusion member 478 of the second catheter 470 is disposed in a proximal position relative to the occlusion member 468 of the first catheter 478 .
- the first catheter 460 extends within the proximal end portion 471 and the distal end portion 472 when disposed in the first lumen 473 .
- the occlusion member 468 of the first catheter 460 can be disposed in a distal position relative to the occlusion member 478 of the second catheter 470 .
- the occlusion member 478 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a body lumen (e.g., artery) in which the occlusion member 478 is disposed.
- the occlusion member 478 can be substantially similar to the occlusion member 468 of the first catheter 468 .
- the arrangement of the second catheter 470 can be such that the second lumen 474 is in fluid communication with the occlusion member 468 .
- the distal end portion 472 of the second catheter 470 defines a channel 475 that places the second lumen 474 in fluid communication with the occlusion member 478 .
- the pressurized fluid can be delivered to the occlusion member 478 via the lumen 431 of the third port 430 (and/or the lumen 436 of the fourth port 435 ), the second lumen 474 of the second catheter 470 , and the channel 475 of the second catheter 470 .
- the pressurized fluid can transition the occlusion member 478 between a collapsed configuration (not shown) and an expanded configuration (as shown in FIGS. 20 and 29 ).
- the arrangement of the second catheter 470 can be such that the third lumen 476 is in fluid communication with the opening 479 (see, e.g., FIG. 28 ).
- the distal end portion 472 of the second catheter 470 defines a channel 477 that places the third lumen 476 in fluid communication with the opening 479 , as shown in FIG. 28 .
- the irrigation fluid or therapeutic agent can be delivered to an isolated segment of a bodily lumen via the lumen 441 defined by the fifth port 440 and the third lumen 476 , the channel 477 , and the opening 479 defined by the second catheter 470 .
- the device 400 can be moved from the first configuration to the second configuration by moving the actuator 450 from its first position (e.g., a distal position) relative to the handle 410 to its second position (e.g., a proximal position) relative to the handle 410 , as indicated by the arrow BB in FIG. 29 .
- the actuator 450 moves from its first position to its second position relative to the first catheter 460 , as indicated by the arrow CC in FIG. 29 .
- a first distance D 7 ( FIG. 20 ) can be defined between the occlusion member 468 of the first catheter 460 and the occlusion member 478 of the second catheter 470 .
- the movement of the second catheter 470 in the CC direction increases the distance between the occlusion member 468 of the first catheter 460 and the occlusion member 478 of the second catheter 470 to a second distance D 8 , as shown in FIG. 29 .
- a segment or volume having a desired length can be defined between the occlusion member 468 of the first catheter 460 and the occlusion member 478 of the second catheter 470 .
- a guidewire can be inserted into the lumen 426 of the second port 425 and through the second lumen 465 defined by the first catheter 460 .
- the guidewire can be advanced through a bodily lumen and the device 400 can be manipulated to advance the first catheter 460 and the second catheter 470 along the guidewire.
- the distal end portion 462 of the first catheter 460 and the distal end portion 472 of the second catheter 470 can be placed at a target location within the bodily lumen such as, for example, the haptic or splenic artery of the pancreas, as shown in FIG. 30 .
- the actuator 450 can be moved between its first position and its second position relative to the handle 410 (e.g., the BB direction in FIG. 29 ) to define a desired distance (e.g., the distance D 8 in FIG. 29 ) between the occlusion member 468 of the first catheter 460 and the occlusion member 478 of the second catheter 470 .
- the occlusion member 468 of the first catheter 460 and the occlusion member 478 of the second catheter 470 can be transitioned from a collapsed or deflated configuration to an expanded or inflated configuration to substantially isolate a segment of the bodily lumen disposed therebetween (e.g., the pancreatic segment or portion of the splenic artery 40 associated with, for example, the dorsal pancreatic artery 42 and/or the pancreatic magnum artery 44 ), as shown in FIG. 30 .
- FIG. 30 is an illustration of the catheter device 400 disposed in situ within the splenic branch of the celiac artery.
- the occlusion elements 468 and 478 define or isolate an area of interest in between the occlusion elements 468 and 478 .
- the region or area of interest with blood supply to the pancreas is isolated via the occlusion elements 468 and 478 , spaced according to the location of the dorsal pancreatic artery 42 and the pancreatic magnum artery 44 .
- a biological/therapeutic agent can be delivered to the substantially isolated segment via the fifth port 440 , the third lumen 476 , and the opening 479 (i.e., the infusion aperture), into the area substantially isolated between the occlusion elements 468 and 478 .
- the substantially isolated segment can be irrigated by coupling an irrigation source to the fifth port 440 .
- the irrigation can be delivered to the substantially isolated segment via the lumen 441 of the fifth port 440 and the third lumen 476 , the channel 477 , and the opening 479 of the second catheter 470 .
- such irrigation can be delivered prior to the delivery of the biological/therapeutic agent, after the delivery of the biological/therapeutic agent, or substantially concurrently with the biological/therapeutic agent.
- FIG. 31 is a flowchart illustrating a method of accessing and treating a pancreas.
- the method can be used, for example, to occlude a portion of the splenic branch of the celiac artery supplying the pancreatic tail.
- the method includes introducing a catheter (e.g., the catheter device 100 , 200 , 300 , and/or 400 ) into a mammalian body over a guidewire ( 211 , 311 ) into a celiac artery, at 501 .
- a catheter e.g., the catheter device 100 , 200 , 300 , and/or 400
- a guidewire 211 , 311
- the catheter device can include an inner catheter (e.g., the first catheter 160 , 260 , 360 , and/or 460 ) slidably coupled to an outer catheter (e.g., the second catheter 170 , 270 , 370 , and/or 470 ).
- an inner catheter e.g., the first catheter 160 , 260 , 360 , and/or 460
- an outer catheter e.g., the second catheter 170 , 270 , 370 , and/or 470
- a guide catheter can be exchanged over the guidewire into the celiac artery for support and introduction of the catheter device.
- the catheter device can be positioned over the guidewire, at 502 , and positioned to allow placement of a distal occlusion element (e.g., the distal occlusion element 168 , 268 , 368 , and/or 468 ) of the inner catheter at a distal edge of the pancreatic portion of the splenic artery (see, e.g., FIG. 30 ).
- a distal occlusion element e.g., the distal occlusion element 168 , 268 , 368 , and/or 468
- the distal occlusion element and a proximal occlusion element (e.g., the proximal occlusion element 178 , 278 , 378 , and/or 478 ) of the outer catheter are positioned to isolate a target portion of the pancreatic artery and moved to an expanded configuration, at 503 .
- contrast dye is injected through an injection port of the outer catheter and the isolated area of the splenic artery is visualized to identify the pancreatic branches, at 504 .
- Visualization enables the clinician to confirm isolation of the pancreatic magnum artery and dorsal pancreatic artery or any other large artery supplying the pancreatic body or tail in the area, at 505 .
- Some example isolation regions include: (a) the pancreatic magnum artery 44 (and its branches), (b) the dorsal pancreatic artery 42 if the origin is within the splenic artery 40 , and (c) both pancreatic magnum artery 44 and dorsal pancreatic artery 42 arteries are isolated in one contiguous area (if other extra-pancreatic arteries do not arise between the origin of the two within the splenic artery 40 ).
- the placement of the outer catheter of the catheter device can allow the edge of the distal occlusion element to be placed beyond this artery.
- the inner catheter can be secured in place, and the outer catheter can be moved relative to the inner catheter to allow the maximum perfusion area to the body and tail of the pancreas. Frequent injection of contrast through the infusion port can be made to ensure no extra-pancreatic vessels are included in the isolated area.
- the therapeutic cells/biologics/agent is introduced to the isolated area of the splenic artery through the infusion port of the outer catheter, at 506 .
- the infusion port design can allow rapid and atraumatic infusion of cells/biologics/agent into the isolated area. This allows the clinician to adjust rate of infusion of therapeutic cells/biologics/agents into the isolated area based on specific pharmacodynamics and or engraftment efficiency requirements.
- the infusion of the therapeutic material can be followed by heparinized blood to exclude any residual cells left behind in the dead space of the catheter device.
- the guidewire port can be used to perform perfusion of the splenic artery beyond the isolated area.
- the guidewire can be removed from its port after the catheter device is in place, and the guidewire port can be connected to a source of arterial blood with suitable pressure (i.e. the side port of an arterial sheath or guide sheath).
- a source of arterial blood with suitable pressure i.e. the side port of an arterial sheath or guide sheath.
- the same catheter can be used to isolate arterial branches supplying the head of the pancreas via the hepatic artery or superior mesenteric artery.
- One such clinical possibility is treatment of pancreatic cancer with the tumor located in the head of the pancreas.
- the infusion of contrast through the infusion port can identify the branches most proximate to the tumor, and then after occluding the distal and proximal portion of the artery around the branch(es), the chemotherapeutic agent can be delivered selectively to the area of interest in the pancreas.
- a method can include introducing a catheter device into a splenic artery.
- the catheter device can include an inner catheter, a first expandable occlusion element coupled to the inner catheter, an outer catheter defining a first lumen configured to introduce a therapeutic biologic/agent to one or more target pancreatic vessels, a second lumen configured to slidably receive at least a portion of the inner catheter, and a second expandable occlusion element coupled to the outer catheter and disposed proximally to the first occlusion element.
- the catheter is advanced to a target pancreatic portion of the splenic artery. A region of the target pancreatic portion of the splenic artery is selectively isolated and the therapeutic biologic/agent is injected into the isolated region.
- the therapeutic biologic/agent includes stem cells.
- the method further includes advancing at least a portion of the catheter device to an ostium of a celiac artery, its hepatic branch, or if necessary, the superior mesenteric artery (based on individual anatomy).
- a contrast dye is injected into the isolated region and isolation of a pancreatic magnum artery and/or a dorsal pancreatic artery can be confirmed.
- a guidewire can be disposed through the infusion lumen to focally perforate the vascular lumen in the isolated area to increase exogenous cell penetration into the pancreatic tissue.
- the therapeutic biologic can be introduced into the isolated segment or region to enhance cellular transmigration across the endothelial cells prior to introduction of the therapeutic biologic.
- a method can include introducing a catheter device into a bile duct.
- the catheter device 200 can be placed at a desired location within the bile duct and used to infuse a therapeutic agents into the bile duct which will diffuse through the bile duct into the pancreas.
- a length of the first catheter 260 and the second catheter 270 can be adjusted such that a selected portion of the bile duct is isolated between the first occlusion element 268 and the second occlusion element 278 .
- a therapeutic agent can be injected through the catheter device 200 and into the isolated region of the bile duct.
- the infusion pressure in the isolated blood vessel region can be measured with pressure monitoring through the infusion lumen of the catheter (with a monometer (not shown) in line with infusion port 279 ).
- the pressure in the third lumen 276 can be based on the size of the agents being delivered, on the flow rate, the viscosity of the solution, and/or flow resistance of the third lumen 276 of second catheter 270 .
- the flow resistance of the catheter device 200 can in turn be determined based on, for example, the inner coating material, the size and the length of the third lumen 276 , the size of the third port 240 , and/or the size of the distal infusion aperture 279 .
- the catheter device 200 can allow for rapid infusion of agents (e.g., up to 2 milliliter per second (ml/sec)). In some applications, the rapid infusion can enhance uptake and eventual engraftment.
- a catheter device can include two catheters slidably coupled where an inner catheter defines a guidewire housing port and a distal occlusion element, and an outer catheter forms an infusion port and a proximal occlusion element, along with an inner lumen allowing the insertion of the inner catheter.
- the two catheters can be assembled outside the body with a distance between the two occlusion elements set to a desired length.
- the minimum distance between the two occlusion elements can be 3 cm, and the length can be adjusted up to a distance between the two occlusion elements of 25 cm as needed.
- kits for use in the delivery of a biological agent to an area proximal to the pancreas can include, for example, one or more catheter devices (e.g., the catheter devices 100, 200, 300, and/or 400) as described herein and one or more biologic/therapeutic agent for delivery to the pancreas.
- the catheter devices can include, for example, a proximal end portion, a distal end portion and one or more expandable devices, such as a balloon or a filter, associated therewith.
- the catheter device can include a first catheter configured to be slidably received within a lumen of a second catheter, a first occlusion element coupled to the first catheter and a second occlusion element coupled to the second catheter.
- a distance between the first and second occlusion elements can be varied or adjusted.
- the occlusion elements can be expandable to engage a wall of a blood vessel thereby substantially isolating an interior region of the vessel between the first and second occlusion elements.
- the first and second catheters can be configured such that at least one of the first and second catheters has a lumen configured to deliver a biological/therapeutic agent to the isolated interior region via an infusion port.
- the infusion port can allow for rapid and atraumatic delivery of cells/biologics into the isolated area.
- a pressure regulator can be provided that is configured to regulate the fluid pressure of the agent or the materials used to dilate the occlusion element(s) (e.g., in a balloon embodiment).
- a kit can further include one or more biologic/therapeutic agents for delivery to the pancreas, a stylet(s); one or more catheters adapted and configured for accessing the pancreatic vessels; a dilator; a guidewire; a guide catheter; capsules for direct connection of biological materials/cells to the infusion port of the delivery catheter; a manometer to monitor the pressure in the isolated area; and/or a pump to regulate the infusion rate of cells/biologics.
- any of the components of a kit can be packaged together and collectively sold as a catheter device or can be packaged independently or in subgroups and sold together or separately.
- the handle 410 can be packaged independently from the first catheter 460 and the second catheter 470 .
- the first catheter 460 and the second catheter 470 can be packaged independent from one another or packaged together.
- the handle 410 can be sold independent of the first catheter 460 and the second catheter 470 .
- the first catheter 460 and the second catheter 470 can be sold independent of one another or together.
- the handle 410 can be packaged independent of the first catheter 460 and the second catheter 470 and, prior to use, can be coupled to the first catheter 460 and the second catheter 470 such that the first set of ports 428 are in fluid communication with the corresponding lumen of the first catheter 460 and the second set of ports 443 are in fluid communication with the corresponding lumen of the second catheter 470 .
- the handle 410 can be, for example, reusable, while the first catheter 460 and the second catheter 470 are disposable.
- the handle 410 can be coupled to the first catheter 460 and the second catheter 470 during, for example, a manufacturing process and packaged together to be sold as a complete catheter device.
- placement of the occlusion elements e.g., the distal occlusion elements 168 , 268 , 368 , and/or 468 and the proximal occlusion elements 178 , 278 , 378 , and/or 478
- placement of the occlusion elements can be varied based on the needs of the individual application.
- the catheter devices 100 , 200 , 300 and/or 400 can retain sufficient trackability to allow advancement into the target region of the patient.
- the catheter material can be flexible enough to traverse local anatomy yet have enough tensile strength to be able to be placed in position in place over a guidewire (e.g., the guidewire 280 and/or 380 ).
- first catheters 160 , 260 , 360 , and 460 and the second catheters 170 , 270 , 370 , and 470 respectively, to be slidable relative to each other in situ, various radial and tensile strengths can be incorporated in each.
- the first catheters 160 , 260 , 360 , and/or 460 (i.e., the inner catheters) and the second catheters 170 , 270 , 370 , and/or 470 (i.e., the outer catheters) can be fabricated of any material suitable for catheters, such as linear low density or high density polyethylene, nylon, polyurethane, polypropylene, silicone rubber, or other non-thrombogenic materials.
- an outer catheter can be formed from a linear low-density polyethylene, while an inner catheter can be formed from a nylon.
- the outer catheters described herein can be fabricated to include a structure for reinforcement (not shown), such as a metal braid or the like located between an inner and outer layer. The reinforcement structure can extend along any desired length of such outer catheters. In some embodiments, a reinforcement structure can extend along the entire length of an outer catheter.
- regions of a first catheter i.e., an inner catheter
- regions of a first catheter can also be fabricated in any manner that allows the relative stiffness of each region to vary.
- an outer layer in each region of an outer catheter and/or an inner catheter can include a material with a different durometer measurement of hardness.
- the material used in an intermediate region can be relatively harder than that used in a distal region, and the material used in a proximal region can be relatively harder than that used in the intermediate region.
- Other manners of varying the stiffness of an inner catheter and/or an outer catheter can include varying the length of a reinforcement structure, varying the degree of reinforcement provided by the reinforcement structure along the length of the inner catheter and/or the outer catheter, changing a cross-sectional size and/or shape of the inner catheter and/or the outer catheter, introducing and/or forming one or more discontinuities along a length of the inner catheter and/or the outer catheter (e.g., one or more ribs, notches, grooves, protrusions, etc.), and/or any other suitable means for varying stiffness.
- the catheter devices described herein can include one or more sensors that can provide relative information such as, for example, position of the occlusion members, movement of the actuator, flow rate of the biological agent, and/or any other suitable information.
- a sensor can be operably coupled to the actuator 450 of the device 400 and can be configured to provide information associated with a distance that the actuator 450 has been moved.
- a user and/or an electronic device can determine a distance between the occlusion member 468 of the first catheter 460 and the occlusion member 478 of the second catheter 470 based on the information from the sensor.
- a sensor can be disposed within the third lumen 476 of the second catheter 470 that can be configured to determine a flow rate of irrigation and/or a biological/therapeutic agent therethrough.
- radiopaque markers of gold or tantalum can also be provided on or in an inner catheter positioned, within or on an occlusion element(s) (e.g., the occlusion elements 168 , 178 , 268 , 278 , 368 , 378 , 468 , and/or 478 ), and/or on an outer catheter to aid in visualization and to assist in monitoring the position of at least a portion of a catheter device (e.g., the catheter devices 100 , 200 , 300 , and/or 400 ) on an imaging device (e.g., a fluoroscope, an X-Ray, a Magnetic Resonance Imaging (MRI) scan, a computerized tomography (CT) scan, and/or the like) during a procedure.
- an imaging device e.g., a fluoroscope, an X-Ray, a Magnetic Resonance Imaging (MRI) scan, a computerized tomography (CT) scan, and/or the like
- an inner catheter can optionally be coated with a lubricous material, such as silicone, acrylamide, or a hydrophilic polyurethane coating, to ease retraction.
- a lubricous material such as silicone, acrylamide, or a hydrophilic polyurethane coating
- the outer catheter and the occlusion elements can be coated with the lubricous material to ease advancement through a guiding catheter and/or a tortuous vessel.
- an outer diameter of an outer catheter e.g., the second catheters 100 , 200 , 300 and/or 400
- non-deployed occlusion elements e.g., the occlusion elements 168 and 178 , 268 and 278 , 368 and 378 , and/or 468 and 478
- an outer diameter of an outer catheter can be, for example, between about 6 French and about 8 French and thus, can be used with, for example, a 7-9 French guiding catheter (if need be).
- a corresponding lumen e.g., the second lumen 165 , 265 , 365 , and/or 465 of the first catheter 160 , 260 , 360 , and/or 460 , respectively
- occlusion end e.g., the distal end portion
- any suitable configuration of the catheter devices can be used to achieve the objectives described herein including, for example, employing one or more catheter devices 100 , 200 , 300 , and/or 400 , employing a contiguous inflation/occluding section having differing stiffness along its length to achieve the two occluding elements, and/or the like.
- a catheter device such as those described herein can include anatomical and mechanical features such as, for example, isolation of the two ends of the pancreatic portion of the artery using two occlusion elements; adjustment of the diameter of the occlusion elements to meet the specific anatomical needs; adjustment of the distance between the two occlusion elements (based on individual variation to selectively isolate for instance the portion of the splenic artery 40 to the pancreas 30 on one hand and maximize the perfusion area on the other hand); an infusion port where injection of contrast can be used to visualize the area of the artery isolated; an infusion port, shaft, and/or aperture design to allow atraumatic and rapid delivery of cells/therapeutic agents; and/or recovery of the occlusion element along with the catheter at the end
- any portion of the catheter devices 100 , 200 , 300 , and/or 400 can be rotated to allow for a more targeted delivery of the biological/therapeutic agent to a selected tissue.
- the catheter device 100 , 200 , 300 , and/or 400 can be rotated to rotate the second catheter 470 relative to the pancreas 30 .
- the infusion aperture 279 , 379 , and/or 479 is rotated about a longitudinal axis (not shown) defined by the second catheter 270 , 370 , and/or 470 .
- any portion of the catheter device 200 , 300 , and/or 400 can include indicia and/or markings that can be associated with the relative position of the infusion aperture 279 , 379 , and/or 479 .
- a user can visualize the radial position of, for example, an actuator (e.g., the actuator 450 ) to determine the radial position of the infusion aperture 279 , 379 , and/or 479 .
- a catheter device can include two catheters slidably coupled where an inner catheter defines a guidewire housing port and a distal occlusion element, and an outer catheter forms an infusion port and a proximal occlusion element, along with an inner lumen allowing the insertion of the inner catheter.
- the two catheters can be assembled outside the body with a distance between the two occlusion elements set to a desired length.
- the minimum distance between the two occlusion elements can be 3 cm, and the length can be adjusted up to a distance between the two occlusion elements of 25 cm as needed.
- a catheter device such as those described herein, which is suitable for accessing the pancreas 30 (see e.g., FIG. 1 ) can include features and/or functions, such as, for example, selective isolation of the targeted portion of the pancreatic portion of the splenic artery 40 for targeted delivery of the therapeutic agent to the pancreas 30 ; an adjustable distance between the two ends of the perfusion/infusion area (e.g., an isolated region) to accommodate individual anatomy to allow isolation of the largest portion of the splenic artery 40 with branches only supplying the pancreatic tail 32 and body 34 (see e.g., FIG.
- the same catheter can be used to isolate portions of the hepatic artery 54 and/or superior mesenteric artery 52 supplying the head of the pancreas 38 ; an infusion port allowing first, injection of contrast into the isolated segment to allow direct visualization of the origin of the branches of the splenic artery 40 supplying the pancreatic tissue, and second, introduction of therapeutic drugs/cells, the dimensions and design of the infusion port and catheter shaft allowing rapid and atraumatic delivery of cells; adjustable diameter of the proximal and/or distal occluders to allow both intravariable and intervariable sizes of the splenic artery 40 ; and/or a self-contained assembly unit with easy retrieval after completion of the procedure.
- the outer catheters 170 , 270 , 370 , and/or 470 of the catheter devices 100 , 200 , 300 , and/or 400 include an infusion lumen (i.e., a third lumen) and infusion port and/or aperture to deliver a cell/biologic/therapeutic material to a desired blood vessel
- the inner catheter 160 , 260 , 360 , and/or 460 can include the infusion lumen.
- a guidewire lumen can be alternatively, or in addition to, included in and/or defined by the outer catheter 170 , 270 , 370 , and/or 470 .
- any of the lumens of the catheter devices 100 , 200 , 300 , and/or 400 can be defined by either the first catheter 160 , 260 , 360 , and/or 460 (i.e., an inner catheter) or the second catheter 170 , 270 , 370 , and/or 470 (i.e., an outer catheter).
- the sealing element 285 and/or 385 can alternatively be coupled to the first catheter 260 and/or 360 .
- a catheter device can include a combination of occlusion elements.
- a catheter device such as those described herein can include one or more balloon occlusion elements (e.g., the balloon elements 268 and/or 278 ) and one or more filter element occlusion elements (e.g., the filter elements 368 and/or 378 ).
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Abstract
Disclosed is a localized method for treatment of cancer including the steps of providing a drug delivery catheter; navigating the catheter to the bile duct; and delivering a therapeutic agent into the bile duct. According to one aspect of the method, the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may include at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
Description
- This application is a continuation of U.S. application Ser. No. 15/351,922, filed Nov. 15, 2016, which is a continuation-in-part of U.S. application Ser. No. 14/958,415, filed Dec. 3, 2015, now abandoned, which is a continuation-in-part of U.S. patent application Ser. No. 14/870,833, filed Sep. 30, 2015, now U.S. Pat. No. 9,463,304, which is a continuation of U.S. patent application Ser. No. 14/293,603, filed Jun. 2, 2014, now U.S. Pat. No. 9,457,171, which claims priority to and the benefit U.S. Provisional Patent Application No. 61/830,218, filed Jun. 3, 2013, and which is also a continuation-in-part of U.S. patent application Ser. No. 12/958,711, filed Dec. 2, 2010, now U.S. Pat. No. 8,821,476, which claims priority to and the benefit of U.S. Provisional Patent Application No. 61/265,845, filed Dec. 2, 2009, each of the disclosures of which is incorporated herein by reference in its entirety.
- The embodiments described herein relate generally to methods for delivering a therapeutic material to treat pancreatic cancer.
- Pancreatic cancer is considered an almost chemoresistant tumor. The ineffective result of systemic chemotherapy is at least in part due to an insufficient drug concentration within the tumor because of dose-limited toxicity in bone marrow and epithelial tissue. Since systemic chemotherapy is limited its effectiveness, localized therapy can be desirable for advanced pancreatic cancer patients. For example, one such treatment can include local intra-arterial delivery of chemotherapy. Intra-arterial infusion allows higher drug concentration to reach the tumor, overcoming the problem of poor blood flow to tumor mass in comparison to healthy tissue. Furthermore, intra-arterial chemotherapy can also take advantage of the first pass effect of chemotherapeutics, generating higher-level drug concentrations at the tumor cell membrane and therefore, enhancing cellular drug uptake as compared to intravenous infusion. Lastly, local delivery can reduce systemic side effects.
- Such a chemotherapy treatment is usually administered through catheters placed in the celiac/hepatic artery or portal vein, however, a best mode of catheter placement has yet to be established. The tumor response rates of pancreatic arterial infusion chemotherapy can range widely, for example, from 7% to 65%, at least in part due to efficacy of drug delivery where anticancer drugs were administered via the celiac artery without assessment of drug distribution. Thus, a need exists for improved methods for delivering a treatment such as a biologic agent and/or drug formation to target tissue of the pancreas, as well as hepatic tumors and cholangiocarinoma.
- Disclosed is a localized method for treatment of cancer, comprising the steps of:
- providing a drug delivery catheter; navigating the catheter to the bile duct; delivering a therapeutic agent into the bile duct.
- According to one aspect of the aforementioned method, wherein the drug delivery catheter is a multi-occlusion balloon catheter. The multi-occlusion balloon catheter may comprise at least two balloons. The multi-occlusion balloon catheter may optionally include a pressure transducer between the balloons to optimize delivery technique.
- According to one aspect of the aforementioned method, the therapeutic agent is selected from the group (5-fluorouracil (5-FU), Aldesleukin, Axitinib, Bleomycin, Carboplatin, Cetuximab, Cisplatin, Cyclophosphamide, Dacarbazine, Doxorubicin Hydrochloride, doxorubicin liposomal non-pegylated (un-coated), doxorubicin liposomal pegylated (PEG coated), Floxuridine, Gemcitabine Hydrochloride, Irinotecan Hydrochloride Liposome, Lanreotide Acetate, leucovorin (antidote to folic acid antagonist used with 5FU), Methotrexate, Mitomycin, Mitoxantrone, Nivolumab, Olaparib, Oxaliplatin, Sorafenib Tosylate, Temsirolimus, Thiotepa, Topotecan Hydrochloride, Vinblastine Sulfate, vincristine sulfate).
- According to one aspect of the aforementioned method, the navigating step includes navigating the catheter using ERCP.
- According to one aspect of the aforementioned method, the navigating step includes navigating the catheter to the bile duct percutaneously.
- According to one aspect of the aforementioned method, the localized method is used to treat pancreatic cancer.
- According to one aspect of the aforementioned method, the localized method is used to treat at least one of hepatic tumors and cholangiocarinoma.
-
FIG. 1 is an illustration of a pancreas and related structure in a human; -
FIGS. 2 and 3 are schematic illustrations of a multi-occlusion catheter insertion device according to an embodiment, in a first configuration and a second configuration, respectively; -
FIG. 4 is a side view of a multi-occlusion catheter insertion device according to an embodiment, shown in a dilated configuration; -
FIG. 5 is a side view of a portion of the multi-occlusion catheter insertion device of -
FIG. 4 ; and -
FIGS. 6-11 are each a cross-sectional view of a different portion of the multi-occlusion catheter insertion device ofFIG. 4 , taken along lines 6-6, 7-7, 8-8, 9-9, 10-10, and 11-11, respectively, inFIG. 5 . -
FIG. 12 is a side view of a multi-occlusion catheter insertion device according to an embodiment. -
FIG. 13 is a side view of a portion of the multi-occlusion catheter insertion device ofFIG. 12 . -
FIGS. 14-19 are each a cross-sectional view of a different portion of the multi-occlusion catheter insertion device taken along lines 14-14, 15-15, 16-16, 17-17, 18-18, and 19-19, respectively, inFIG. 13 . -
FIG. 20 is a top view of a multi-occlusion catheter insertion device according to an embodiment, in a first configuration. -
FIG. 21 is a side view of a handle included in the multi-occlusion catheter insertion device ofFIG. 20 . -
FIG. 22 is a top view of a handle included in the multi-occlusion catheter insertion device ofFIG. 20 . -
FIG. 23 is an enlarged cross-sectional view of a portion of the handle ofFIG. 21 , indicated by the region X1 and taken along the line 23-23 inFIG. 22 . -
FIG. 24 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device ofFIG. 20 , taken along the line 24-24. -
FIG. 25 is an enlarged cross-sectional view of a portion of the handle ofFIG. 21 , indicated by the region X2 and taken along the line 25-25 inFIG. 22 . -
FIG. 26 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device ofFIG. 20 , taken along the line 26-26. -
FIG. 27 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device ofFIG. 20 , taken along the line 27-27. -
FIG. 28 is a cross-sectional view of a portion of the multi-occlusion catheter insertion device ofFIG. 20 , taken along the line 28-28. -
FIG. 29 is a top view of the multi-occlusion catheter insertion device ofFIG. 20 in a second configuration. -
FIG. 30 is an illustration of a portion of the multi-occlusion catheter insertion device of -
FIG. 20 in use within a portion of a body. -
FIG. 31 is a flowchart illustrating a method for treating the pancreas, according to an embodiment. - Methods described herein can be used, for example, for the insertion and manipulation of a multi-occlusion catheter device to deliver a therapeutic agents to the bile duct for treatment of pancreatic cancer or other localized cancer. Tumors localized around the bile duct (cancer of the pancreatic head, primary and secondary liver tumors, and cholangiocarcinoma) may benefit from localized delivery through the bile duct itself. The bile duct can be exogenously accessed through an endoscopic retrograde cholangiopancreatogram (ERCP) catheter, one can envision delivery of a double balloon catheter into the bile duct using established ERCP technique. After localizing the double balloon catheter to the area of bile duct involved/adjacent to the tumor, that area of bile duct is isolated by inflating the two balloon elements. Chemotherapeutic elements are then infused between the two balloons. By increasing the pressure between two balloon elements to exceed the interstitial tissue pressure, in a diffusion dependent manner, the chemotherapeutic agent will then diffuse out the wall of the bile duct and into the tissue.
- By monitoring and/or adjusting the pressure between the balloons, one can change the penetration depth of the chemotherapy into the tissue.
- According to some embodiments, a therapeutic material for treatment of pancreatic cancer or other localized cancer is delivered into the bile duct using the multi-occlusion catheter. The gall bladder is connected to the pancreas via the common bile duct.
- Localized delivery to the site of the tumor has advantages for both maximizing local drug concentration at the tumor site, and decreasing systemic side effects/toxicity. Thus the approach disclosed herein may avoid some of the toxicity related side effects of delivering chemotherapy drugs directly to the pancreas and may enable the use of more concentrated dosage of chemotherapy drugs. It should be understood that therapeutic particles may be substituted for or used in conjunction with chemotherapy drugs. Moreover, it should be understood that in some cases it may be useful to place a stent to open the bile duct prior to delivering the chemotherapy and/or therapeutic agent.
- By way of example, such a use can include navigating a catheter such as a multi-occlusion catheter to the target anatomy using conventional percutaneous approaches or the same approach used for endoscopic retrograde cholangiopancreatogram (ERCP), isolating the bile duct, and then exogenously introducing therapeutic cells/agents/biologics into the isolated area, via an infusion port of the catheter. In such fashion, the cells/agents biologics can be delivered to the bile duct with high efficiency. In some embodiment, a device with two sliding balloon catheters can be used to isolate bile duct. The isolated area can then be perfused with cells/therapeutic agents via an infusion port disposed between the two balloon catheters. In some embodiments, the devices described herein can be arranged such that a user can manipulate a portion of the device substantially single handedly, to allow for accurate delivery of a biological agent and/or drug formulation to an isolated segment or portion of an organ.
- This application incorporates by reference to co-pending U.S. application Ser. No. 14/958,415 filed on December 3, 2015.
- In some embodiments, an apparatus includes a handle, an inner catheter, an outer catheter, an actuator, a first occlusion element, and a second occlusion element. The inner catheter is coupled to the handle and the first occlusion element is coupled to the inner catheter. The inner catheter defines an inner catheter lumen that is configured to receive a guidewire. The outer catheter is coupled to the housing and the second occlusion element is coupled to the outer catheter. The outer catheter defines a first lumen that is in fluid communication with a distal opening and is configured to introduce a therapeutic agent through the distal opening into the bile duct. The outer catheter defines a second lumen that is configured to receive at least a portion of the inner catheter.
- The actuator is coupled to the handle and is configured to move the outer catheter relative to the handle. The second occlusion element is disposed proximal to the first occlusion element and a distance therebetween is adjustable when the outer catheter is moved relative to the handle by the actuator.
- In some embodiments, an apparatus includes a handle, an inner catheter, an outer catheter, a first occlusion element, a second occlusion element, and an actuator. The inner catheter is coupled to the handle and the first occlusion element is coupled to the inner catheter. The outer catheter is coupled to the housing and the second occlusion member is coupled to the outer catheter. The outer catheter defines a first lumen that is in fluid communication with a distal opening and that is configured to introduce a therapeutic agent therethrough and into the bile duct. The outer catheter defines a second lumen that is configured to receive at least a portion of the inner catheter. The second occlusion element is disposed proximal of the first occlusion element. The actuator is coupled to the handle and is configured to move the outer catheter relative to the handle between a first position in which the second occlusion element is at a first distance from the first occlusion element and a second position in which the second occlusion element is at a second distance from the first occlusion element, with the second distance being greater than the first distance.
- In some embodiments, a system and/or device(s) is provided for endovascular introduction of therapeutic materials selectively to the bile duct for the treatment of pancreatic cancer. In some embodiments, a device and/or system can include, for example, an inner catheter having a distal retractable occlusion element and an inner catheter lumen adapted and configured to introduce a guidewire, and an outer catheter having a distal retractable occlusion element, an infusion lumen adapted and configured to introduce therapeutic materials to the bile duct, and a lumen for slidably receiving the inner catheter. In such an embodiment, the distal retractable occlusion element of the outer catheter can be positioned proximal to the distal retractable occlusion element of the inner catheter; and a sealing element can be included that is configured to selectively isolate or seal an end of the outer catheter to prevent therapeutic materials from entering into the lumen of the outer catheter in which the inner catheter is slidably disposed.
- In some embodiments, a selective sealing element can include, for example, a ring, a membrane, or any other suitable element configured to prevent loss of therapeutic material into the lumen of the outer catheter in which the inner catheter is disposed. The lumen provided in the inner catheter can be configured to perfuse a distal organ beyond the targeted isolation region of the artery.
- In some embodiments, a distance between the proximal retractable occlusion element and the selective sealing element can be configured for external adjustment, thus allowing a user to customize the isolated area (between the two occlusion elements) to better target the bile duct during delivery of biologics. The proximal retractable occlusion element and the selective sealing element can have a cross-sectional diameter, for example, between 2-12 mm.
- In some embodiments, the devices and methods described herein can be used for isolating the perfusion area of the gall bladder for introduction of chemotherapy for treatment of pancreatic cancer, hepatic tumors and cholangiocarinoma or other therapeutic agents targeted to the pancreas.
- As used in this specification, the singular forms “a,” “an” and “the” include plural referents unless the context clearly dictates otherwise. Thus, for example, the term “a member” is intended to mean a single member or a combination of members, “a material” is intended to mean one or more materials, or a combination thereof.
- As used herein, the term “set” can refer to multiple features or a singular feature with multiple parts. For example, when referring to a set of ports, the set of ports can refer to a single port or to multiple ports.
- As used herein, the words “proximal” and “distal” refer to a direction closer to and away from, respectively, an operator of, for example, a medical device. Thus, for example, the end of the medical device closest to the patient's body (e.g., contacting the patient's body or disposed within the patient's body) would be the distal end of the medical device, while the end opposite the distal end and closest to, for example, the user of the medical device, would be the proximal end of the medical device. Said another way, the distal end portion is the end that is located furthest from a point of reference, such as an origin or a point of attachment. For example, the distal end portion would be the end farthest away from a user's hand. The proximal end portion, thus, would be the position nearer to a point of reference such as an origin, i.e., the user's hand.
- Table 1 is a list of chemotherapy drugs which may be delivered to the bile duct according to the method of the present invention.
-
TABLE 1 Trade Common Solvents/ # Drug Name(s) Indication(s) Diluents 1 5-fluorouracil 5FU, Breast, Liver, water (5-FU) Flourouracil, Pancreatic, Adrucil Stomach 2 Aldesleukin Proleukin Kidney water 3 Axitinib Inlyta Kidney water 4 Bleomycin Blenoxane Cervical, water Testicular 5 Carboplatin Paraplatin Ovarian water 6 Cetuximab Erbitux Colorectal, water Head, Neck 7 Cisplatin Platinol-AQ Bladder, Liver, water Ovarian, Pancreatic, Testicular 8 Cyclo- Cytoxan Breast, Ovarian, water phosphamide Pancreatic 9 Dacarbazine DTIC-Dome Pancreatic water 10 Doxorubicin Adriamycin, Breast, Liver, water Hydrochloride Rubex, Ovarian, (pH = 3) Caelyx Pancreatic, Stomach 11 doxorubicin Myocet Breast, Liver, water liposomal, non- Ovarian, (pH = 3) pegylated (un- Pancreatic, coated) Stomach 12 doxorubicin Doxil Breast, Liver, water liposomal, Ovarian, (pH = 3) pegylated (PEG Pancreatic, coated) Stomach 13 Floxuridine FUDR Liver, Pancreatic water 14 Gemcitabine Hospira, Breast, Ovarian, water Hydrochloride Gemcitab, Pancreatic (pH = 3) Gemzar 15 Irinotecan Onivyde, Pancreatic water Hydrochloride Camptosar (pH = 3) Liposome 16 Lanreotide Somatuline Pancreatic water Acetate 17 leucovorin Depot Pancreatic water or (antidote to folic oral acid antagonist used with 5FU) 18 Methotrexate Otrexup, Breast, water Rheumatrex, Pancreatic Trexall 19 Mitomycin Mutamycin, Liver, water MMC, Pancreatic, Mitomycin C, Stomach Mitozytrex 20 Mitoxantrone Novantrone Pancreatic water 21 Nivolumab Opdivo Kidney water 22 Olaparib Lynparza Ovarian water 23 Oxaliplatin Elotaxin Pancreatic water 24 Sorafenib Nexavar Kidney water Tosylate 25 Temsirolimus Torisel Kidney water 26 Thiotepa Bladder, water Ovarian 27 Topotecan Hycamtin Cervical, water Hydrochloride Ovarian (pH = 3) or oral 28 Vinblastine Velban, Breast, water Sulfate Velsar Pancreatic, Testicular 29 vincristine Alcrist, Pancreatic water sulfate Biocristin, Oncocristin- AQ, VCR -
FIG. 1 illustrates theliver 10, thegall bladder 20, and thepancreas 30 situated within an abdominal cavity (not shown) of a mammal (e.g., a human). Thepancreas 30 is a gland organ which is part of the digestive and endocrine system of vertebrates. Thepancreas 30 is both an endocrine gland producing hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme. - As shown, the common bile duct leads from the gall bladder to the
pancreas 30. -
FIGS. 2 and 3 are schematic illustrations of a multi-occlusioncatheter insertion device 100 useful for delivering therapeutic agents to the bile duct for treatment of pancreatic cancer. The multi-occlusion catheter insertion device 100 (also referred to herein as “device”) can be arranged to allow for substantially single handed use to, for example, isolate a segment of a bodily lumen such as the buke duct, thereby allowing a procedure to be performed within the isolated segment and/or allowing a targeted delivery of a biological or therapeutic agent. Thedevice 100 includes ahandle 110, anactuator 150, afirst catheter 160, and asecond catheter 170. Thehandle 110 can be any suitable shape, size, or configuration. For example, in some embodiments, thehandle 110 can have a shape and size that are configured to enhance the ergonomics of thedevice 100. As described in further detail herein, thehandle 110 can be grasped by a user to insert a portion of thefirst catheter 160 and a portion of thesecond catheter 170 into a bodily lumen of a patient and can be manipulated to move, inflate, deflate, adjust, and/or otherwise reconfigure the portion of thefirst catheter 160 and the portion of thesecond catheter 170 within the bodily lumen. For example, thesecond catheter 170 can be moved relative to thefirst catheter 160, or vice-versa, to adjust a distance between afirst occlusion element 168 coupled to a distal end portion of thefirst catheter 160 and asecond occlusion element 178 coupled to a distal end portion of thesecond catheter 170. Thedevice 100 can be used to isolate a segment of the bile duct within the space defined between thefirst occlusion element 168 and thesecond occlusion element 178. Thus, a procedure can then be performed within the isolated segment such as for example, delivering a therapeutic agent to the isolated segment. - The
handle 110 has aproximal end portion 111 and adistal end portion 112. As described in further detail herein, thehandle 110 can be arranged to enclose, house, and/or be disposed about a portion of thefirst catheter 160 and thesecond catheter 170. For example, thefirst catheter 160 and thesecond catheter 170 can each be coupled to thehandle 110. Afirst port 120 and a second port 125 (collectively referred to herein as a first set of ports 128) are each disposed at theproximal end portion 111 of thehandle 110. Thefirst port 120 and thesecond port 125 can each define a lumen (not shown inFIGS. 2 and 3 ). In some embodiments, thefirst port 120 and thesecond port 125 can be formed monolithically or integrally with thefirst catheter 160. Thefirst port 120 and thesecond port 125 can be any suitable size, shape, or configuration. For example, in some embodiments, thefirst port 120 and thesecond port 125 can extend from theproximal end portion 111 of thehousing 110 such that at least a portion of thefirst port 120 and thesecond port 125 is accessible outside of thehandle 110. Although not shown inFIGS. 2 and 3 , thefirst port 120 and thesecond port 125 can each be physically and fluidically coupled to a device, mechanism, and/or the like, such as, for example, a source of an inflation medium as described in more detail below. For example, in some embodiments, thefirst port 120 and thesecond port 125 can each include a Luer-Lok® or the like that can physically and fluidically couple thefirst port 120 and/or thesecond port 125 to such a device. As described in further detail herein, the first set ofports 128 can be in fluid communication with at least a portion of thefirst catheter 160 to place at least the portion of thefirst catheter 160 in fluid communication with a device (e.g., a source of an inflation medium) coupled to thehandle 110 via thefirst port 120 and/or thesecond port 125. For example, the lumen of thefirst port 120 can be in fluid communication with a first lumen defined by thefirst catheter 160 and the lumen of thesecond port 125 can be in fluid communication with a second lumen defined by thefirst catheter 160. - The
distal end portion 112 of thehandle 110 includes athird port 130, afourth port 135, and a fifth port 140 (collectively referred to herein as a second set of ports 143). The second set ofports 143 can be any suitable arrangement such as, for example, described above with reference to the first set ofports 128. For example, thethird port 130, thefourth port 135, and thefifth port 140 can each define a lumen (not shown inFIGS. 2 and 3 ) and can each include a Luer-Lok® or the like that can physically and fluidically couple thethird port 130, thefourth port 135, and/or thefifth port 140 to any suitable attachment, device, mechanism, and/or the like. For example, thethird port 130, thefourth port 135, and/or thefifth port 140 can each be coupled to an external device such as a device supplying a therapeutic agent, a device supplying an inflation medium or a device supplying an irrigation solution as described in more detail below with reference to, for example,device 400. In some embodiments, the second set ofports 143 includes thefifth port 140 and only one of thethird port 130 and thesecond port 135. - As described in further detail herein, the second set of
ports 143 can be in fluid communication with at least a portion of thesecond catheter 170 to place at least the portion of thesecond catheter 170 in fluid communication with such external devices coupled to thehandle 110 via thethird port 130, thefourth port 135, and/or thefifth port 140. For example, thethird port 130 and/or thefourth port 135 can be coupled to and in fluid communication with a first lumen defined by thesecond catheter 170, and thefifth port 140 can be coupled to and in fluid communication with a second lumen defined by thesecond catheter 170. In some embodiments, thethird port 130, thefourth port 135, and/or thefifth port 140 can be monolithically or integrally formed with thesecond catheter 170. Moreover, the second set ofports 143 can be coupled to or operably coupled to theactuator 150 as described in more detail herein. - The first catheter 160 (also referred to herein as “inner catheter”) and the second catheter 170 (also referred to herein as “outer catheter”) can be any suitable catheter device. For example, in some embodiments, the
first catheter 160 and thesecond catheter 170 are multi-lumen catheters. As shown inFIG. 2 , thefirst catheter 160 has aproximal end portion 161 and adistal end portion 162. Theproximal end portion 161 of thefirst catheter 160 is disposed within a portion of thehandle 110. More specifically, theproximal end portion 161 of thefirst catheter 160 can be fixedly disposed within the portion of thehandle 110 to place thefirst catheter 160 in fluid communication with one or more of theports ports 128. In some embodiments, thefirst catheter 160 can define a first lumen that can be physically and fluidically coupled to thefirst port 120 and a second lumen that can be physically and fluidically coupled to thesecond port 125. In other embodiments, a first catheter can be coupled to the handle and can be operably coupled to a first port and a second port (e.g.,ports 120, 125) via an intervening structure such as, for example, flexible tubing or the like. In this manner, thefirst port 120 can be placed in fluid communication with a first lumen (not shown inFIGS. 2 and 3 ) defined by thefirst catheter 160, as described in further detail herein. Similarly, thesecond port 125 can be placed in fluid communication with a second lumen (not shown inFIGS. 2 and 3 ) defined by thefirst catheter 160. In some embodiments, thesecond port 125 and the second lumen of thefirst catheter 160 can receive a guidewire or the like, as described in further detail herein. - The
distal end portion 162 of thefirst catheter 160 extends beyond a distal end portion of thehandle 110 and includes theocclusion member 168. Theocclusion member 168 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a bodily lumen in which theocclusion member 168 is disposed. For example, in some embodiments, theocclusion member 168 can be an inflatable balloon or the like that can be transitioned between a collapsed (e.g., deflated) configuration and an expanded (e.g., inflated) configuration. In some embodiments, the arrangement of thefirst catheter 160 and thehandle 110 can be such that thefirst port 120 is in fluid communication with theocclusion member 168. Thus, in use, thefirst port 120 can be fluidically coupled to a device that can supply a pressurized fluid (e.g., air, inert gas, or liquid) to theocclusion member 168 to transition theocclusion member 168 between a collapsed configuration and an expanded configuration, as described in further detail herein. - The
second catheter 170 of thedevice 100 has aproximal end portion 171 and adistal end portion 172. As shown inFIGS. 2 and 3 , thesecond catheter 170 is movably disposed about a portion of thefirst catheter 160. More specifically, thesecond catheter 170 can be, for example, a multi-lumen catheter and can be arranged such that thefirst catheter 160 is movably disposed within a first lumen (not shown inFIGS. 2 and 3 ) defined by thesecond catheter 170. Theproximal end portion 171 can be movably disposed within thehandle 110 such that a portion of thesecond catheter 170 is in fluid communication with the second set ofports 143. In some embodiments, thesecond catheter 170 can be physically and fluidically coupled to thethird port 130 and thefourth port 135, and/or thefifth port 140. In other embodiments, the second catheter can be disposed within a handle and can be operably coupled to one or more ports via an intervening structure such as, for example, flexible tubing or the like. In this manner, thethird port 130 and/or thefourth port 135 can be placed in fluid communication with the second lumen (not shown inFIGS. 2 and 3 ) defined by thesecond catheter 170, as described in further detail herein; thefifth port 140 can be placed in fluid communication with a third lumen (not shown inFIGS. 2 and 3 ) defined by thesecond catheter 170, as described in further detail herein. - The
distal end portion 172 of thefirst catheter 170 extends beyond a distal end portion of thehandle 110 and includes anocclusion member 178. Theocclusion member 178 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a lumen in which theocclusion member 178 is disposed. For example, in some embodiments, theocclusion member 178 can be substantially similar to theocclusion member 168 of thefirst catheter 160. In some embodiments, the arrangement of thesecond catheter 170 and thehandle 110 can be such that thethird port 130 and/or thefourth port 135 is in fluid communication with theocclusion member 178. Thus, in use, thethird port 130 and/or thefourth port 135 can be fluidically coupled to a device that can supply a pressurized fluid (e.g., air, inert gas, or liquid) to theocclusion member 178 to transition theocclusion member 178 between a collapsed configuration and an expanded configuration, as described in further detail herein. In some embodiments, at least a portion of theocclusion member 178 can be selectively permeable to allow a biological agent to pass therethrough. Although not shown inFIGS. 2 and 3 , in some embodiments, thedistal end portion 172 of thesecond catheter 170 can define one or more openings. In such embodiments, thefifth port 140 can be fluidically coupled to a device that can supply irrigation, therapeutic material or agents, biological agents, and/or the like to a volume or region disposed between theocclusion member 168 of thefirst catheter 160 and theocclusion member 178 of thesecond catheter 170. - As described above, the
actuator 150 of thedevice 100 can be operably coupled to the second set ofports 143. For example, in some embodiments, theactuator 150 is included in and/or coupled to thehandle 110 and arranged relative to the second set ofports 143 to be operably coupled thereto. Theactuator 150 can be any suitable device, mechanism, assembly, etc. that is movable between a first position relative to thehandle 110, associated with thedevice 100 in the first configuration (FIG. 2 ), and a second position relative to thehandle 110, associated with thedevice 100 in the second configuration (FIG. 3 ). Furthermore, with theactuator 150 operably coupled to the second set ofports 143, theactuator 150 can be operable in moving the second set ofports 143 between a first position relative to the handle 110 (e.g., the distal position) and a second position relative to the handle 110 (e.g., the proximal position), as indicated by the arrow AA inFIG. 3 . Thus, when thesecond catheter 170 is coupled to the second set ofports 143, theactuator 150 can also move thesecond catheter 170 relative to thehandle 110 and/or relative to thefirst catheter 160 as described in more detail below. - In some embodiments, the
actuator 150 can be a push or pull slide that can move within a track (not shown inFIGS. 2 and 3 ) defined by thehandle 110. In other embodiments, theactuator 150 can be coupled to an energy storage device (e.g., a spring, compressed gas, etc.) that is configured to move theactuator 150. For example, theactuator 150 can include a push button that allows a spring to transition from a compressed configuration towards an uncompressed configuration to move theactuator 150 relative to thehandle 110. In other embodiments, a portion of theactuator 150 can be rotated to move theactuator 150 between its first position and its second position relative to thehandle 110. With thesecond catheter 170 physically and fluidically coupled to the second set of ports 143 (as described above), the movement of theactuator 150 can move thesecond catheter 170 relative to thehandle 110. More specifically, theproximal end portion 171 of thesecond catheter 170 can be movably disposed within the handle 110 (as described above) such that when theactuator 150 is moved from its first position to its second position, theproximal end portion 171 of thesecond catheter 170 is moved from a first position relative to the handle 110 (e.g.,FIG. 2 ) to a second position relative to the handle 110 (e.g.,FIG. 3 ). - With the
second catheter 170 movably disposed about thefirst catheter 160, the movement of theactuator 150 moves thesecond catheter 170 relative to thefirst catheter 160. For example, when thedevice 100 is in the first configuration, a first distance D1 is defined between theocclusion member 168 of thefirst catheter 160 and theocclusion member 178 of thesecond catheter 170. Therefore, with thefirst catheter 160 fixedly disposed within thehandle 110, the movement of thesecond catheter 170 in the proximal direction (e.g., the AA direction) increases the distance between theocclusion member 168 of thefirst catheter 160 and theocclusion member 178 of thesecond catheter 170 to a second distance D2, as shown inFIG. 3 . - In use, a guidewire (not shown) can be inserted into the
second port 125 and through a lumen defined by thefirst catheter 160. In this manner, the guidewire can be advanced through a bodily lumen and thedevice 100 can be manipulated to advance thefirst catheter 160 along the guidewire to place thedistal end portion 162 of thefirst catheter 160 and thedistal end portion 172 of thesecond catheter 170 at a target location within the bodily lumen. Once at the target location, theactuator 150 can be moved in the AA direction (e.g., the proximal direction) to define a desired distance between theocclusion member 168 of thefirst catheter 160 and theocclusion member 178 of thesecond catheter 170, thereby placing thedevice 100 in the second configuration (FIG. 3 ). As described above, an inflation source can be coupled to thesecond port 125 of thefirst catheter 160 and the same inflation source or a second inflation source can be coupled to thethird port 130 and/or thefourth port 135 of thesecond catheter 170. With the desired distance defined between theocclusion members occlusion members occlusion members occlusion members fourth port 135. For example, the biological or therapeutic agent can be delivered through thefourth port 135 into a lumen of the second catheter that is in fluid communication with the opening (see, e.g., opening 479 inFIG. 20 ) defined by thedistal end portion 172 of thesecond catheter 170. In some instances, the substantially isolated segment can be irrigated by coupling an irrigation source to thefifth port 140. Thus, the irrigation is delivered to the substantially isolated segment via the opening (described above) defined by thedistal end portion 172 of thesecond catheter 170. -
FIGS. 4-11 illustrate adilation catheter 200 according to an embodiment.FIG. 4 is a side view of the dilation catheter device 200 (also referred to herein as “catheter device”). In this embodiment, dilatation of two balloons is used to occlude a desired length of an artery such as, for example, the splenic artery 40 (see, e.g.,FIG. 2 ). Specifically, thecatheter device 200 includes a first catheter 260 (also referred to herein as “inner catheter”) and a second catheter 270 (also referred to herein as “outer catheter”), a first Y-adaptor 228 (also referred to herein as “first set of ports”) and a second Y-adaptor 243 (also referred to herein as “second set of ports”), a first occlusion element 268 (also referred to herein as “dilation element”, “occluder,” or “distal occlusion element”), and a second occlusion element 278 (also referred to herein as “dilation element”, “occluder,” or “proximal occlusion element”) each configured to occlude a portion of an artery. Thefirst occlusion element 268 is coupled to thefirst catheter 260 and thesecond occlusion element 278 is coupled to thesecond catheter 270. - The
occlusion elements catheter device 200 into a body of a patient (e.g., into an artery) and an expanded configuration (also referred to as “dilated configuration” or “inflated configuration”) for occluding a portion of an artery. Theocclusion elements - The
catheter device 200 includes adistal end portion 212 and aproximal end portion 211. In this embodiment, theocclusion elements first catheter 260 and an outer surface of thesecond catheter 270, respectively, and are disposed at thedistal end portion 212 of thecatheter device 200. Thecatheter device 200 is shown in a dilated configuration inFIG. 4 with theocclusion elements 268 and 278 (i.e., balloons) in their expanded configuration (i.e., inflated, dilated). -
FIG. 5 is a side view of thedistal end portion 212 of the catheter device 200 (e.g., a distal end portion of thefirst catheter 260 and the second catheter 270) andFIGS. 6-11 illustrate cross-sections at various locations along thedistal end portion 212 of thecatheter device 200 to illustrate the various lumens of thecatheter device 200. As shown inFIGS. 6-11 , thefirst catheter 260 defines afirst lumen 265 and asecond lumen 263 that each can extend a length of thefirst catheter 260. Thefirst lumen 265 can be configured to receive a guidewire 280 (shown, for example, inFIG. 4 ). Thesecond lumen 263 can be used to communicate an inflation medium to and from thefirst occlusion element 268 via anaperture 264 in fluid communication with the first occlusion element 268 (see, e.g.,FIG. 10 ). - As shown, for example, in
FIGS. 6 and 7 , thesecond catheter 270 defines afirst lumen 274, asecond lumen 273, and athird lumen 276. Thefirst lumen 274 can be used to communicate an inflation medium to and from thesecond occlusion element 278 via anaperture 275 in fluid communication with the second occlusion element 278 (see, e.g.,FIG. 7 ). Thesecond lumen 273 is configured to slidably receive at least a portion of thefirst catheter 260 therethrough, as shown inFIGS. 6-9 . Thethird lumen 276 can terminate and be in fluid communication with aninfusion aperture 279 near adistal end 272 of the second catheter 270 (see, e.g.,FIG. 8 ). Theinfusion aperture 279 can be used to communicate a cell/biological/therapeutic material to a desired location within a body/artery of a patient. - The first Y-
adaptor 228 is coupled to thefirst catheter 260 and includes twoports FIG. 4 . Theport 220 defines a lumen (not shown) that is in fluid communication with thefirst lumen 263 of thecatheter 260 and can be used to communicate an inflation medium to thefirst occlusion element 268 through thesecond lumen 263. For example, a source of an inflation medium (not shown) can be coupled to thecatheter device 200 via theport 220 of the first Y-adaptor 228. Theport 225 defines a lumen (not shown) that is in fluid communication with thesecond lumen 265 of the first catheter 260 (see, e.g.,FIGS. 6-11 ) and can be used for introduction of theguidewire 280 into thesecond lumen 265. - The second Y-
adapter 243 is coupled to thesecond catheter 270 and includes threeports FIG. 4 . Theport 230 defines a lumen (not shown) that is in fluid communication with thesecond lumen 273 of the second catheter 270 (see, e.g.,FIGS. 6-11 ) and can receive thefirst catheter 260 therethrough. Theport 235 defines a lumen (not shown) that is in fluid communication with thefirst lumen 274 of thesecond catheter 270 and can be used to communicate an inflation medium to and from thesecond occlusion element 278 in a similar manner as described above forport 225 andlumen 263. Theport 240 defines a lumen (not shown) that is in fluid communication with thethird lumen 276 of the second catheter 270 (see e.g.,FIG. 6-11 ) and can be used to introduce cells/biological/therapeutic materials into and through thethird lumen 276 and out through theinfusion aperture 279. - The
catheter device 200 can also include a seal element 285 (see, e.g.,FIG. 9 ) (also referred to a as a “seal”, “sealing element”, “selective sealing element”, or “filter-ring”) disposed at or near adistal end 272 of thesecond catheter 270. Theseal element 285 can prevent the entry of cells and or biologics that have been injected into an artery from flowing back into thelumen 273. By doing so, a maximum number of cells can be delivered to the treatment area, and improve engraftment efficiency. Theseal element 285 can be for example, a ring, a membrane or other known sealing elements used in medical devices. - The slidable coupling of the
first catheter 260 within thesecond lumen 273 of thesecond catheter 270 allows a collective length of thefirst catheter 260 and thesecond catheter 270 to be adjusted by slidably moving thefirst catheter 260 and thesecond catheter 270 relative to each other. Because thefirst occlusion element 268 is coupled to thefirst catheter 260 and thesecond occlusion element 278 is coupled to thesecond catheter 270, the slidable adjustment of thefirst catheter 260 and thesecond catheter 270 can thus allow adjustment of a distance between thesecond occlusion element 278 and thefirst occlusion element 268. Thesecond lumen 273 of thesecond catheter 270 can be sized to receive thefirst catheter 260 with sufficient clearance to allow for ease of sliding/adjustment. - In use, the
catheter device 200 can be placed at a desired location within an artery, such as for example, within a splenic artery 40 (see e.g.,FIG. 1 ) and used to infuse a cell/biological material to apancreas 30. A length of thefirst catheter 260 and thesecond catheter 270 can be adjusted such that a selected portion (e.g., a pancreatic portion) of thesplenic artery 40 is isolated between thefirst occlusion element 268 and thesecond occlusion element 278. A cell/biologic material can be injected through thecatheter device 200 and into the isolated region of thesplenic artery 40. - The infusion of a cell/biological agent can occur in the localized region surrounding the isolated region or segment of
vessel 40. In some instances, however, the presence of one or more additional, side-branching vessels forming a flow-restricting configuration in the isolated region ofvessel 40 can allow infusion to occur in a larger semi-localized region. - To allow the operator to accommodate the location of these side branches to fall within the isolated region, the
first catheter 260 can be configured such that it is slidably associated with thesecond catheter 270 and the space between (e.g., distance between)occlusion elements distal occlusion element 268 within an artery can be individualized based on the specific anatomy to allow an enclosed or isolated area between the twoocclusion elements - The cells targeted to the pancreas 30 (see e.g.,
FIG. 1 ) can be infused throughinfusion port 240, traverse through thethird lumen 276, and exit through theinfusion aperture 279 into the area isolated between the twoocclusion elements catheter device 200 can be configured to enable delivery of target cells, such as insulin producing beta cells, and autologous stem cells (mesenchymal, bone marrow, and others) to blood vessels in communication with the pancreas in situ. The infusion pressure in the isolated blood vessel region can be measured with pressure monitoring through the infusion lumen of the catheter (with a monometer (not shown) in line with infusion port 279). The pressure in thethird lumen 276 can be based on the size of the cells being delivered, on the flow rate, the viscosity of the solution, and/or flow resistance of thethird lumen 276 ofsecond catheter 270. The flow resistance of thecatheter device 200 can in turn be determined based on, for example, the inner coating material, the size and the length of thethird lumen 276, the size of thethird port 240, and/or the size of thedistal infusion aperture 279. Thecatheter device 200 can allow for rapid infusion of cells (e.g., up to 2 milliliter per second (ml/sec)). In some applications, the rapid infusion of cells can enhance uptake and eventual engraftment. Smaller aperture size (e.g., the infusion aperture 279), lumen size (e.g., the third lumen 276), and increased flow resistance may cause “sludging” of cells, leading to poor intra-arterial flow and diminished uptake. Lastly, theinfusion aperture 279 and luminal design of thecatheter device 200 can be configured to minimize risk of mechanical cell damage during the infusion process. -
FIG. 12 illustrates an embodiment of acatheter device 300 that uses two filter elements, instead of expandable balloons to occlude and isolate the area of interest for infusion of cells or chemotherapeutic agents, without inhibiting the flow of plasma through the isolated area. The filter elements can be formed with, for example, a medical mesh material. The size of the pores of the filter elements can be, for example, about 2 microns (μm) or less in length, which can inhibit cells from passing through the filter element, but not impede serum/plasma and other components from passing through the filter element. Thecatheter device 300 can be used for the same or similar functions as described above forcatheter device 200. For example, thecatheter device 300 can be used for introduction of cells or other biologic or therapeutic material into a desired location within a patient's body, such as within a splenic artery. - The
catheter device 300 includes afirst catheter 360 and asecond catheter 370 that can be slidably coupled together as described above forcatheter device 200, a first Y-adaptor 328 (also referred to herein as “first set of ports”) coupled to thefirst catheter 360, a second Y-adaptor 343 (also referred to herein as “second set of ports”) coupled to thesecond catheter 370, a first occlusion element 368 (also referred to herein as “dilation element”, “occluder”, “distal occlusion element”) and a second occlusion element 378 (also referred to herein as “dilation element”, “occluder”, “proximal occlusion element”) to occlude a portion of an artery. Thefirst occlusion element 368 is coupled to thefirst catheter 360 and thesecond occlusion element 378 is coupled to thesecond catheter 370. - In this embodiment, the
occlusion elements catheter device 300 into a body of a patient (e.g., into an artery) and an expanded configuration (also referred to as “dilated configuration” or “open configuration”), as shown inFIG. 12 , for occluding a portion of an artery. Theocclusion elements - The
catheter device 300 includes adistal end portion 312 and aproximal end portion 311.FIG. 13 is a side view of thedistal end portion 312 of thecatheter device 300 andFIGS. 14-19 illustrate cross-sections at various locations along thedistal end portion 312 of thecatheter device 300. As shown inFIGS. 14-19 , thefirst catheter 360 defines afirst lumen 363 and asecond lumen 365 that each can extend a length of thefirst catheter 360. Thefirst lumen 363 can be configured to receive awire deployment device 382 that can be coupled to thefilter element 368 and configured to move thefilter element 368 from its expanded or open configuration and its collapsed or closed configuration. Thesecond lumen 365 can be configured to receive a guidewire 380 (shown inFIG. 12 ). - The
second catheter 370 defines afirst lumen 373, asecond lumen 374, and athird lumen 376. Thefirst lumen 373 is configured to slidably receive at least a portion of thefirst catheter 360 therethrough. Thesecond lumen 374 can be configured to receive awire deployment device 381. Thewire deployment device 381 can be coupled to thefilter element 378 and used to move thefilter element 378 between its expanded or open configuration and its collapsed or closed configuration. Thethird lumen 376 can terminate and be in fluid communication with an infusion aperture 379 (see, e.g.,FIG. 16 ) near adistal end 372 of thesecond catheter 370. Theinfusion aperture 379 can be used to communicate, for example, a cell or cells (or other therapeutic or biologic material) to a desired location within a body of a patient. - The first Y-
adaptor 328 includes aport 320 and aport 325 as shown inFIG. 12 . Theport 320 defines a lumen (not shown) that is in fluid communication with thefirst lumen 363 of thecatheter 360. Theport 325 defines a lumen (not shown) that is in fluid communication with thesecond lumen 365 of thecatheter 360, and can be used for introduction of theguidewire 380 into thesecond lumen 365. The second Y-adapter 343 includes threeports FIG. 12 . Theport 330 defines a lumen (not shown) that is in fluid communication with thefirst lumen 373 of thesecond catheter 370 and can receive thefirst catheter 360 therethrough. Theport 335 defines a lumen (not shown) that is in fluid communication with thesecond lumen 374 of thesecond catheter 370, and theport 335 defines a lumen (not shown) that is in fluid communication with thethird lumen 376 of thesecond catheter 370. - The
filter elements FIGS. 12 and 13 . Thefilter elements catheter device 300 is to be deployed. After infusion of cells or a therapeutic/biologic material through thecatheter device 300, thefilter elements catheter device 300 from the patient. - In some embodiments, a diameter of the occlusion elements (e.g., 268, 278, 368, and 378) when expanded within an artery, such as, for example, the
splenic artery 40, can be adjustable to meet anatomical variations including a) individual variability in the size of thesplenic artery 40 and b) end to end variation as the artery size can taper down between the two ends of the artery. As such, in some embodiments, to allow successful isolation of the area for treatment, the proximal occlusion element (e.g., theballoon 278 and/or the filter element 378) can be sized (e.g., have an outer diameter or outer perimeter) between, for example, 3-12 mm and the distal occlusion element (e.g., theballoon 268 and/or the filter element 368) between, for example, 3-12 mm. The proximal occlusion element can be larger than the distal occlusion element, smaller than the distal occlusion element, or the same size as the distal occlusion element. - Referring now to
FIGS. 20-29 , a multi-lumencatheter insertion device 400 is illustrated according to an embodiment. The multi-occlusion catheter insertion device 400 (also referred to herein as “catheter device” or “device”) includes ahandle 410, anactuator 450, a first catheter 460 (also referred to herein as “inner catheter”), and a second catheter 470 (also referred to herein as “outer catheter”) and can be movable between a first configuration and a second configuration. As described in further detail herein, thedevice 400 can be grasped by a user (e.g., a doctor, physician, surgeon, technician, etc.) and manipulated substantially single handedly to insert a portion of thefirst catheter 460 and a portion of thesecond catheter 470 into a bodily lumen of a patient and to move, inflate, deflate, adjust, and/or otherwise reconfigure the portion of thefirst catheter 460 and the portion of thesecond catheter 470 within the bodily lumen. For example, thesecond catheter 470 can be moved relative to thefirst catheter 460, and vice-versa, to adjust a distance between afirst occlusion element 468 coupled to a distal end portion of thefirst catheter 460 and asecond occlusion element 478 coupled to a distal end portion of thesecond catheter 470. Thedevice 400 can be used to isolate a segment of a bodily lumen within the space or region defined between thefirst occlusion element 468 and thesecond occlusion element 478. Thus, a procedure can then be performed within the isolated segment such as, for example, delivering a cell or a therapeutic/biological agent to the isolated segment. - The
handle 410 of thedevice 400 can be any suitable shape, size, or configuration. For example, in some embodiments, thehandle 410 can have a shape and size that can enhance the ergonomics of thedevice 400. More specifically, thehandle 410 has aproximal end portion 411, adistal end portion 412, and amedial portion 413 that can be shaped in such a manner as to be easily gripped by a user (e.g., a doctor, physician, surgeon, technician, etc.). In some embodiments, thehandle 410 can include a grip section 417 (see, e.g.,FIG. 21 ) or the like that can have, for example, a rough surface finish, detents, protrusions, or the like that can enhance the ergonomics of thehandle 410. In other embodiments, the grip section can be, for example, an insert, an over-mold, or the like that is formed from a relatively deformable material and that can have a relatively high coefficient of friction, thereby enhancing the ergonomics of thehandle 410. - The
proximal end portion 411 of thehandle 410 includes afirst port 420 and asecond port 425 collectively referred to herein as a first set of ports 428). Thefirst port 420 and thesecond port 425 can be any suitable size, shape, or configuration. In some embodiments, thefirst port 420 and thesecond port 425 can be coupled together via any suitable method (e.g., an adhesive, ultrasonic welding, mechanical fastener, and/or the like). In other embodiments, thefirst port 420 and thesecond port 425 can be monolithically formed. - The
first port 420 and thesecond port 425 can extend from theproximal end portion 411 of thehandle 410 such that at least a portion of thefirst port 420 and thesecond port 425 is accessible, as shown inFIGS. 20 and 21 . In some embodiments, the first set ofports 428 can be, for example, a first Y-adapter, substantially similar to the Y-adapter 228 and/or 328. In other embodiments, a first port and a second port can be, for example, substantially parallel in a stacked configuration. In yet other embodiments, a handle can include a first port and a second port that are substantially coaxial and arranged in a substantially concentric configuration such that at least a portion of the first port is disposed within the second port, or vice versa. - Although not shown in
FIGS. 14-29 , thefirst port 420 and thesecond port 425 can be physically and fluidically coupled to an exterior device, mechanism, and/or the like as described above, for example, with reference toinsertion device 100. For example, thefirst port 420 and thesecond port 425 can each define a lumen (described in more detail below) in fluid communication with such a device. Thefirst port 420 and thesecond port 425 can each include a Luer-Lok® and/or any other attachment mechanism that can physically and fluidically couple thefirst port 420 and/or thesecond port 425 to any suitable device either directly or indirectly (e.g., by an intervening structure such as a flexible tubing to the like). The first set ofports 428 can be physically and fluidically coupled to thefirst catheter 460 such that when an external device is coupled to thehandle 410 via thefirst port 420 and/or thesecond port 425, at least the portion of thefirst catheter 460 is placed in fluid communication with that external device via thefirst port 420 and/or thesecond port 425. For example, thefirst port 420 can be coupled to a device that can, for example, supply a pressurized fluid (e.g., an inert gas, air, saline, water, and/or any other suitable fluid in gaseous or liquid form) that can flow through thefirst port 420 to be delivered to a portion of thefirst catheter 460, as described in further detail herein. Furthermore, thesecond port 425 can be coupled to a device that can advance a guidewire or the like through thesecond port 425 and into a portion of thefirst catheter 460, as described in further detail herein. In some embodiments, a guidewire or the like can be manually inserted through thesecond port 425 without the use of an external device. - The
distal end portion 412 of thehandle 410 includes athird port 430, afourth port 435, and a fifth port 440 (collectively referred to as a second set of ports 443). In some embodiments, the second set ofports 443 includes thefifth port 440 and only one of thethird port 430 and thesecond port 435. The second set ofports 443 can be any suitable size, shape, or configuration as described above with reference to the first set ofports 428. For example, the second set ofports 443 can be, for example, monolithically and/or unitarily formed. In some embodiments, the second set ofports 443 can be monolithically formed with thecatheter 470. In some embodiments, the second set ofports 443 can be formed with and/or coupled to any suitable structure or component of thehandle 410 such that the second set ofports 443 can be moved relative to thehandle 410 as described in more detail below. - The
third port 430, thefourth port 435, and thefifth port 440 can each include a Luer-Lok® and/or any other attachment mechanism that can physically and fluidically couple thethird port 430, thefourth port 435, and/or thefifth port 440 to any suitable attachment, device, mechanism, and/or the like. The second set ofports 443 can be physically and fluidically coupled to thesecond catheter 470 such that when an external device is coupled to thehandle 410 via thethird port 430, thefourth port 435, and/or thefifth port 440, at least a portion of thesecond catheter 470 is placed in fluid communication with that external device. For example, in some embodiments, thethird port 430 and/or thefourth port 435 can be coupled to a device that can supply a pressurized fluid (as described above) that can flow through thethird port 430 and/or thefourth port 435, respectively, to be delivered to a portion of thesecond catheter 470, as described in further detail herein. In some embodiments, thefifth port 440 is coupled to, for example, an infusion device that is configured to deliver a biological or therapeutic agent and/or other suitable drug formulation to a target tissue via thefifth port 440 and a portion of thesecond catheter 470. In some embodiments, thefifth port 440 can be coupled to, for example, an irrigation device that can deliver an irrigation fluid to, for example, an isolated segment of a bodily lumen via thefifth port 440 and a portion of thesecond catheter 470. In some embodiments, thefifth port 440 can be coupled to, for example, the infusion device configured to deliver the biological agent and/or other suitable drug formulation, as described in further detail herein. - As shown in
FIGS. 20-22 , thehandle 410 defines afirst track 414 and asecond track 416. Thefirst track 414 slidably receives a portion of theactuator 450. More specifically, at least a portion of theactuator 450 can extend through thetrack 414, thereby allowing a user to engage theactuator 450. As such, thetrack 414 can define a path along which theactuator 450 can be moved between a first position relative to thehandle 410 and a second position relative to thehandle 410, as described in further detail herein. In a similar manner, thesecond track 416 slidably receives a portion of thefifth port 440. In this manner, thefifth port 440 can extend through thesecond track 416 to be accessed by a user. Moreover, thesecond track 416 can define a path along which thefifth port 440 can be moved, as described in further detail herein. - Although the
device 400 is particularly shown inFIGS. 20-29 , the arrangement of the first set ofports 428, the second set ofports 443, thefirst track 414 and thesecond track 416 can be arranged along a surface of thehandle 410 in various orientations. For example, although thefirst track 414 is shown as being defined by a top surface of the handle 410 (see, e.g.,FIG. 20 ) and thesecond track 416 as being defined by a side surface of the handle 410 (see, e.g.,FIG. 21 ), in other embodiments, a first track configured to receive an actuator can be defined by a side surface of a handle and a second track configured to receive a fifth port can be defined by a top surface of the handle. Similarly, while the first set ofports 428 and the second set ofports 443 are shown extending from thehandle 410 in a specific orientation, the first set ofports 428 and/or the second set ofports 443 can be oriented in any suitable manner relative to a surface of thehandle 410. - The
actuator 450 of thedevice 400 is operably coupled to the second set ofports 443. - For example, in some embodiments, the
actuator 450 is included in and/or coupled to thehandle 410 and arranged relative to the second set ofports 443 to be operably coupled thereto. In other embodiments, a handle can be arranged such that at least a portion of an actuator is monolithically formed with at least a portion of a second set of ports. In some embodiments, an actuator is operably coupled to a second set of ports via an intervening structure or the like. For example, in some embodiments, the second set ofports 443 can be coupled to a shuttle or the like, which in turn, is coupled to an actuator. Theactuator 450 can be any suitable device, mechanism, assembly, etc. that is movable between the first position relative to thehandle 410, associated with thedevice 400 in the first configuration (FIGS. 20-22 ), and a second position relative to thehandle 410, associated with thedevice 400 in the second configuration (FIG. 29 ). - In some embodiments, the
actuator 450 can be a mechanism that can be pushed or pulled to slide within thefirst track 414 defined by thehandle 410 between its first position and its second position. In some embodiments, theactuator 450 can be arranged to slide relatively smoothly within thetrack 414 when moved between its first position and its second position. In other embodiments, thehandle 410 and/or theactuator 450 can include a set of ribs, teeth, detents, protrusions, etc. that are sequentially engaged as theactuator 450 is moved between its first position relative to thehandle 410 and its second position relative to thehandle 410. In this manner, a user can move the actuator 450 a desired distance that can be quantified by theactuator 450 and/or thehandle 410 engaging a particular surface (e.g., a particular rib, tooth, detent, protrusion, etc.). In some embodiments, thehandle 410 and/or theactuator 450 can be arranged at a predetermined setting that can correspond to a predetermined distance (e.g., 2 cm, 3 cm, etc.) between an end portion of thefirst catheter 460 and an end portion of thesecond catheter 470. In some embodiments, the set of ribs, teeth, detents, protrusions, etc. included in thehandle 410 and/or theactuator 450 can be associated with pre-defined settings and/or adjustments. - Although not shown in
FIGS. 20-29 , in some embodiments, ahandle 410 can include a visual indicator such as a measuring scale or the like. For example, in some embodiments, thehandle 410 can include indicia (e.g., lines, markings, tic marks, etc.) that represents a gradation of a length of travel associated with moving theactuator 450 between its first position relative to thehandle 410 and its second position relative to thehandle 410. In some embodiments, the markings can represent distances of, for example, a centimeter, half a centimeter, a millimeter, and/or the like. In this manner, a user can view the indicia to determine a desired distance to move thatactuator 450 that would otherwise be challenging or indeterminate. In some embodiments, the visual indicator can substantially correspond with the ribs, teeth, detents, protrusions, etc. of thehandle 410 and/oractuator 450. - In some embodiments, the
actuator 450 can be operably coupled to one or more energy storage device (e.g., a spring or the like) that can facilitate the movement of theactuator 450. For example, theactuator 450 can include a push button that can rearrange or reconfigure at least a portion of theactuator 450 to allow a spring to transition from a compressed configuration towards an uncompressed configuration to move theactuator 450 relative to thehandle 410. - With the
actuator 450 coupled to or monolithically formed with a portion of the second set ofports 443, theactuator 450 can be operable in moving the second set ofports 443 between a first position relative to the handle 410 (e.g., a distal position) and a second position relative to the handle 410 (e.g., a proximal position). Moreover, with thesecond catheter 470 physically and fluidically coupled to the second set of ports 443 (as described above), the movement of theactuator 450 and the second set ofports 443 can move thesecond catheter 470 between a first position relative to thehandle 410 and a second position relative to thehandle 410, as described in further detail herein. - The
first catheter 460 and thesecond catheter 470 can be any suitable catheter device. For example, in some embodiments, thefirst catheter 460 and thesecond catheter 470 are multi-lumen catheters. Thefirst catheter 460 has a proximal end portion 461 (see, e.g.,FIGS. 21, 23 and 29 ) and a distal end portion 462 (see, e.g.,FIGS. 20 and 29 ), and defines afirst lumen 463 and a second lumen 465 (see, e.g.,FIGS. 24-28 ). Theproximal end portion 461 of thefirst catheter 460 is disposed within a portion of thehandle 410. More specifically, theproximal end portion 461 of thefirst catheter 460 can be fixedly disposed within the portion of thehandle 410 to place thefirst catheter 460 in fluid communication with the first set ofports 428. In some embodiments, thefirst catheter 460 can be physically and fluidically coupled to the first set ofports 428. In other embodiments, a device can include a first catheter that is monolithically formed with a first set of ports. In this manner, theproximal end portion 461 of thefirst catheter 460 is arranged such that thefirst lumen 463 of thefirst catheter 460 is in fluid communication with alumen 421 defined by thefirst port 420 and thesecond lumen 465 of thefirst catheter 460 is in fluid communication with alumen 426 of thesecond port 425, as shown inFIG. 23 . Therefore, an external device (e.g., a device that can supply a pressurized fluid, as described above) can be physically and fluidically coupled to thefirst port 420 to place the external device in fluid communication with thefirst lumen 463 of thefirst catheter 460. Similarly, an external device including at least a guidewire (not shown) can be coupled to thesecond port 425 and can be manipulated to advance the guidewire through thesecond port 425 and into thesecond lumen 465, as described in further detail herein. - Referring back to
FIG. 20 , thedistal end portion 462 of thefirst catheter 460 extends beyond a distal end portion of thehandle 410 and includes anocclusion member 468. Theocclusion member 468 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a body lumen (e.g., artery) in which theocclusion member 468 is disposed. For example, in some embodiments, theocclusion member 468 can be an inflatable balloon or the like that can be transitioned between a collapsed (e.g., deflated) configuration and an expanded (e.g., inflated) configuration. - The arrangement of the
first catheter 460 can be such that thefirst lumen 463 is in fluid communication with theocclusion member 468. For example, as shown inFIG. 24 , thedistal end portion 462 of thefirst catheter 460 can define achannel 464 that places thefirst lumen 463 in fluid communication with theocclusion member 468. Thus, when thefirst port 420 is fluidically coupled to a device that supplies a pressurized fluid (e.g., air, inert gas, or liquid), the pressurized fluid can be delivered to theocclusion member 468 via thelumen 421 of thefirst port 420, thefirst lumen 463 of thefirst catheter 460, and thechannel 464 of thefirst catheter 460. In this manner, the pressurized fluid can transition theocclusion member 468 between a collapsed configuration (not shown) and an expanded configuration (see e.g.,FIG. 20 ), as described in further detail herein. - The
second catheter 470 of thedevice 400 has a proximal end portion 471 (see, e.g.,FIGS. 20-22 ) and a distal end portion 472 (see, e.g.,FIGS. 20 and 29 ), and defines afirst lumen 473, asecond lumen 474, athird lumen 476 and an opening 479 (also referred to herein as “infusion aperture”) (as shown, for example, inFIGS. 25-28 ). Thesecond catheter 470 is movably disposed about a portion of the first catheter 460 (see, e.g.,FIGS. 21-23 ). More specifically, thesecond catheter 470 can be arranged such that thefirst catheter 460 is movably disposed within thefirst lumen 473 defined by thesecond catheter 470, as shown, for example, inFIGS. 26-28 . - The
proximal end portion 471 of thesecond catheter 470 is movably disposed within thehandle 410 to place thesecond catheter 470 in fluid communication with the second set ofports 443. In some embodiments, thesecond catheter 470 can be physically and fluidically coupled to thethird port 430 and thefourth port 435, and/or thefifth port 440. In other embodiments, a catheter insertion device can include a second catheter that can be movably disposed within a handle and can be operably coupled to one or more ports via an intervening structure such as, for example, flexible tubing or the like. In yet other embodiments, a catheter insertion device can include a second catheter that is monolithically formed with a third port, a fourth port, and/or a fifth port. In this manner, thesecond catheter 470 is arranged such that thefirst lumen 473 of thesecond catheter 470 movably receives thefirst catheter 460, thesecond lumen 474 of thesecond catheter 470 is in fluid communication with alumen 431 defined by thethird port 430 and alumen 436 defined by thefourth port 435, and thethird lumen 476 of thesecond catheter 470 is in fluid communication with alumen 441 defined by thefifth port 440, as shown inFIG. 25 . - Referring back to
FIG. 20 , thedistal end portion 472 of thefirst catheter 470 extends beyond a distal end portion of thehandle 410 such that anocclusion member 478 of thesecond catheter 470 is disposed in a proximal position relative to theocclusion member 468 of thefirst catheter 478. Expanding further, thefirst catheter 460 extends within theproximal end portion 471 and thedistal end portion 472 when disposed in thefirst lumen 473. Thus, theocclusion member 468 of thefirst catheter 460 can be disposed in a distal position relative to theocclusion member 478 of thesecond catheter 470. Theocclusion member 478 can be any suitable device or mechanism that is configured to selectively limit, block, obstruct, or otherwise occlude a body lumen (e.g., artery) in which theocclusion member 478 is disposed. For example, in some embodiments, theocclusion member 478 can be substantially similar to theocclusion member 468 of thefirst catheter 468. - The arrangement of the
second catheter 470 can be such that thesecond lumen 474 is in fluid communication with theocclusion member 468. For example, as shown inFIG. 27 , thedistal end portion 472 of thesecond catheter 470 defines achannel 475 that places thesecond lumen 474 in fluid communication with theocclusion member 478. Thus, when the third port 430 (and/or the fourth port 435) is fluidically coupled to a device that supplies a pressurized fluid, the pressurized fluid can be delivered to theocclusion member 478 via thelumen 431 of the third port 430 (and/or thelumen 436 of the fourth port 435), thesecond lumen 474 of thesecond catheter 470, and thechannel 475 of thesecond catheter 470. In this manner, the pressurized fluid can transition theocclusion member 478 between a collapsed configuration (not shown) and an expanded configuration (as shown inFIGS. 20 and 29 ). In a similar manner, the arrangement of thesecond catheter 470 can be such that thethird lumen 476 is in fluid communication with the opening 479 (see, e.g.,FIG. 28 ). For example, thedistal end portion 472 of thesecond catheter 470 defines achannel 477 that places thethird lumen 476 in fluid communication with theopening 479, as shown inFIG. 28 . Thus, when thefifth port 440 is fluidically coupled to an external device that supplies irrigation or to a device that supplies a therapeutic agent, the irrigation fluid or therapeutic agent can be delivered to an isolated segment of a bodily lumen via thelumen 441 defined by thefifth port 440 and thethird lumen 476, thechannel 477, and theopening 479 defined by thesecond catheter 470. - The
device 400 can be moved from the first configuration to the second configuration by moving the actuator 450 from its first position (e.g., a distal position) relative to thehandle 410 to its second position (e.g., a proximal position) relative to thehandle 410, as indicated by the arrow BB inFIG. 29 . Expanding further, with thesecond catheter 470 movably disposed about thefirst catheter 460 and with theproximal end portion 471 of thesecond catheter 470 operably coupled to theactuator 450, the movement of the actuator 450 from its first position to its second position moves thesecond catheter 470 relative to thefirst catheter 460, as indicated by the arrow CC inFIG. 29 . For example, when thedevice 400 is in the first configuration, a first distance D7 (FIG. 20 ) can be defined between theocclusion member 468 of thefirst catheter 460 and theocclusion member 478 of thesecond catheter 470. With thefirst catheter 460 fixedly disposed within thehandle 410, the movement of thesecond catheter 470 in the CC direction (e.g., the proximal direction) increases the distance between theocclusion member 468 of thefirst catheter 460 and theocclusion member 478 of thesecond catheter 470 to a second distance D8, as shown inFIG. 29 . Thus, a segment or volume having a desired length can be defined between theocclusion member 468 of thefirst catheter 460 and theocclusion member 478 of thesecond catheter 470. - In use, a guidewire can be inserted into the
lumen 426 of thesecond port 425 and through thesecond lumen 465 defined by thefirst catheter 460. In this manner, the guidewire can be advanced through a bodily lumen and thedevice 400 can be manipulated to advance thefirst catheter 460 and thesecond catheter 470 along the guidewire. Thus, thedistal end portion 462 of thefirst catheter 460 and thedistal end portion 472 of thesecond catheter 470 can be placed at a target location within the bodily lumen such as, for example, the haptic or splenic artery of the pancreas, as shown inFIG. 30 . At the target location, theactuator 450 can be moved between its first position and its second position relative to the handle 410 (e.g., the BB direction inFIG. 29 ) to define a desired distance (e.g., the distance D8 inFIG. 29 ) between theocclusion member 468 of thefirst catheter 460 and theocclusion member 478 of thesecond catheter 470. With the desired distance defined between theocclusion members first port 420 and the same or a different inflation source coupled to the third port 430 (and/or the fourth port 435), theocclusion member 468 of thefirst catheter 460 and theocclusion member 478 of thesecond catheter 470, respectively, can be transitioned from a collapsed or deflated configuration to an expanded or inflated configuration to substantially isolate a segment of the bodily lumen disposed therebetween (e.g., the pancreatic segment or portion of thesplenic artery 40 associated with, for example, the dorsalpancreatic artery 42 and/or the pancreatic magnum artery 44), as shown inFIG. 30 .FIG. 30 is an illustration of thecatheter device 400 disposed in situ within the splenic branch of the celiac artery. As shown inFIG. 30 , theocclusion elements occlusion elements occlusion elements pancreatic artery 42 and thepancreatic magnum artery 44. - With the
occlusion members fifth port 440, thethird lumen 476, and the opening 479 (i.e., the infusion aperture), into the area substantially isolated between theocclusion elements fifth port 440. Thus, the irrigation can be delivered to the substantially isolated segment via thelumen 441 of thefifth port 440 and thethird lumen 476, thechannel 477, and theopening 479 of thesecond catheter 470. In some instances, such irrigation can be delivered prior to the delivery of the biological/therapeutic agent, after the delivery of the biological/therapeutic agent, or substantially concurrently with the biological/therapeutic agent. -
FIG. 31 is a flowchart illustrating a method of accessing and treating a pancreas. The method can be used, for example, to occlude a portion of the splenic branch of the celiac artery supplying the pancreatic tail. The method includes introducing a catheter (e.g., thecatheter device first catheter second catheter distal occlusion element FIG. 30 ). The distal occlusion element and a proximal occlusion element (e.g., theproximal occlusion element pancreatic artery 42 if the origin is within thesplenic artery 40, and (c) bothpancreatic magnum artery 44 and dorsalpancreatic artery 42 arteries are isolated in one contiguous area (if other extra-pancreatic arteries do not arise between the origin of the two within the splenic artery 40). - After the first takeoff of the
pancreatic magnum artery 44 is identified (or the dorsal pancreatic artery), the placement of the outer catheter of the catheter device can allow the edge of the distal occlusion element to be placed beyond this artery. At this point, the inner catheter can be secured in place, and the outer catheter can be moved relative to the inner catheter to allow the maximum perfusion area to the body and tail of the pancreas. Frequent injection of contrast through the infusion port can be made to ensure no extra-pancreatic vessels are included in the isolated area. - After the desired area is isolated and the occlusion elements are positioned at a desired location, the therapeutic cells/biologics/agent is introduced to the isolated area of the splenic artery through the infusion port of the outer catheter, at 506. The infusion port design can allow rapid and atraumatic infusion of cells/biologics/agent into the isolated area. This allows the clinician to adjust rate of infusion of therapeutic cells/biologics/agents into the isolated area based on specific pharmacodynamics and or engraftment efficiency requirements. The infusion of the therapeutic material can be followed by heparinized blood to exclude any residual cells left behind in the dead space of the catheter device. During isolation of the artery described above, perfusion to the end organ to the artery spleen can be disrupted, but the redundancy in the arterial perfusion system to the spleen, and limited time during which the arterial supply is interrupted, should prevent any long-term sequela, or abnormal condition of the splenic cells. If needed and/or desired, the guidewire port can be used to perform perfusion of the splenic artery beyond the isolated area. For example, the guidewire can be removed from its port after the catheter device is in place, and the guidewire port can be connected to a source of arterial blood with suitable pressure (i.e. the side port of an arterial sheath or guide sheath). At the end of the infusion, both occlusion elements are moved to a collapsed configuration and the catheter device is removed from the body over the guidewire as one unit, followed by the guidewire and the guide catheter.
- In a variation of the method described above using balloons as the occlusion elements, the same catheter can be used to isolate arterial branches supplying the head of the pancreas via the hepatic artery or superior mesenteric artery. One such clinical possibility is treatment of pancreatic cancer with the tumor located in the head of the pancreas. After placement of the catheter device in the respective artery, the infusion of contrast through the infusion port can identify the branches most proximate to the tumor, and then after occluding the distal and proximal portion of the artery around the branch(es), the chemotherapeutic agent can be delivered selectively to the area of interest in the pancreas.
- In some embodiments, a method can include introducing a catheter device into a splenic artery. The catheter device can include an inner catheter, a first expandable occlusion element coupled to the inner catheter, an outer catheter defining a first lumen configured to introduce a therapeutic biologic/agent to one or more target pancreatic vessels, a second lumen configured to slidably receive at least a portion of the inner catheter, and a second expandable occlusion element coupled to the outer catheter and disposed proximally to the first occlusion element. The catheter is advanced to a target pancreatic portion of the splenic artery. A region of the target pancreatic portion of the splenic artery is selectively isolated and the therapeutic biologic/agent is injected into the isolated region. In some embodiments, the therapeutic biologic/agent includes stem cells. In some embodiments, the method further includes advancing at least a portion of the catheter device to an ostium of a celiac artery, its hepatic branch, or if necessary, the superior mesenteric artery (based on individual anatomy). In some embodiments, a contrast dye is injected into the isolated region and isolation of a pancreatic magnum artery and/or a dorsal pancreatic artery can be confirmed. In some embodiments, a guidewire can be disposed through the infusion lumen to focally perforate the vascular lumen in the isolated area to increase exogenous cell penetration into the pancreatic tissue. In some embodiments, the therapeutic biologic can be introduced into the isolated segment or region to enhance cellular transmigration across the endothelial cells prior to introduction of the therapeutic biologic.
- In some embodiments, a method can include introducing a catheter device into a bile duct. In use, the
catheter device 200 can be placed at a desired location within the bile duct and used to infuse a therapeutic agents into the bile duct which will diffuse through the bile duct into the pancreas. A length of thefirst catheter 260 and thesecond catheter 270 can be adjusted such that a selected portion of the bile duct is isolated between thefirst occlusion element 268 and thesecond occlusion element 278. A therapeutic agent can be injected through thecatheter device 200 and into the isolated region of the bile duct. - The infusion pressure in the isolated blood vessel region can be measured with pressure monitoring through the infusion lumen of the catheter (with a monometer (not shown) in line with infusion port 279). The pressure in the
third lumen 276 can be based on the size of the agents being delivered, on the flow rate, the viscosity of the solution, and/or flow resistance of thethird lumen 276 ofsecond catheter 270. The flow resistance of thecatheter device 200 can in turn be determined based on, for example, the inner coating material, the size and the length of thethird lumen 276, the size of thethird port 240, and/or the size of thedistal infusion aperture 279. Thecatheter device 200 can allow for rapid infusion of agents (e.g., up to 2 milliliter per second (ml/sec)). In some applications, the rapid infusion can enhance uptake and eventual engraftment. - Any catheter device described herein and/or any combination of the catheter devices described herein can allow the above goals to be achieved. For example, a catheter device can include two catheters slidably coupled where an inner catheter defines a guidewire housing port and a distal occlusion element, and an outer catheter forms an infusion port and a proximal occlusion element, along with an inner lumen allowing the insertion of the inner catheter. The two catheters can be assembled outside the body with a distance between the two occlusion elements set to a desired length. For example, in some embodiments, the minimum distance between the two occlusion elements can be 3 cm, and the length can be adjusted up to a distance between the two occlusion elements of 25 cm as needed.
- The devices described herein can also be provided in a kit. In some embodiments, a kit for use in the delivery of a biological agent to an area proximal to the pancreas can include, for example, one or more catheter devices (e.g., the
catheter devices - In some embodiments, a kit can further include one or more biologic/therapeutic agents for delivery to the pancreas, a stylet(s); one or more catheters adapted and configured for accessing the pancreatic vessels; a dilator; a guidewire; a guide catheter; capsules for direct connection of biological materials/cells to the infusion port of the delivery catheter; a manometer to monitor the pressure in the isolated area; and/or a pump to regulate the infusion rate of cells/biologics.
- In some embodiments, any of the components of a kit can be packaged together and collectively sold as a catheter device or can be packaged independently or in subgroups and sold together or separately. For example, in some embodiments, the
handle 410 can be packaged independently from thefirst catheter 460 and thesecond catheter 470. Moreover, thefirst catheter 460 and thesecond catheter 470 can be packaged independent from one another or packaged together. As such, thehandle 410 can be sold independent of thefirst catheter 460 and thesecond catheter 470. Thefirst catheter 460 and thesecond catheter 470 can be sold independent of one another or together. Thus, in some embodiments, thehandle 410 can be packaged independent of thefirst catheter 460 and thesecond catheter 470 and, prior to use, can be coupled to thefirst catheter 460 and thesecond catheter 470 such that the first set ofports 428 are in fluid communication with the corresponding lumen of thefirst catheter 460 and the second set ofports 443 are in fluid communication with the corresponding lumen of thesecond catheter 470. In some embodiments, thehandle 410 can be, for example, reusable, while thefirst catheter 460 and thesecond catheter 470 are disposable. In other embodiments, thehandle 410 can be coupled to thefirst catheter 460 and thesecond catheter 470 during, for example, a manufacturing process and packaged together to be sold as a complete catheter device. - In some embodiments, placement of the occlusion elements (e.g., the
distal occlusion elements proximal occlusion elements catheter devices guidewire 280 and/or 380). Furthermore, for thefirst catheters second catheters - The
first catheters second catheters - In some embodiments, regions of a first catheter (i.e., an inner catheter) such as those described herein can also be fabricated in any manner that allows the relative stiffness of each region to vary. In some embodiments, an outer layer in each region of an outer catheter and/or an inner catheter can include a material with a different durometer measurement of hardness. For example, the material used in an intermediate region can be relatively harder than that used in a distal region, and the material used in a proximal region can be relatively harder than that used in the intermediate region. Other manners of varying the stiffness of an inner catheter and/or an outer catheter (i.e., a first catheter and a second catheter, respectively, such as those described herein) can include varying the length of a reinforcement structure, varying the degree of reinforcement provided by the reinforcement structure along the length of the inner catheter and/or the outer catheter, changing a cross-sectional size and/or shape of the inner catheter and/or the outer catheter, introducing and/or forming one or more discontinuities along a length of the inner catheter and/or the outer catheter (e.g., one or more ribs, notches, grooves, protrusions, etc.), and/or any other suitable means for varying stiffness.
- In some embodiments, the catheter devices described herein can include one or more sensors that can provide relative information such as, for example, position of the occlusion members, movement of the actuator, flow rate of the biological agent, and/or any other suitable information. For example, in some embodiments, a sensor can be operably coupled to the
actuator 450 of thedevice 400 and can be configured to provide information associated with a distance that theactuator 450 has been moved. In such embodiments, a user and/or an electronic device can determine a distance between theocclusion member 468 of thefirst catheter 460 and theocclusion member 478 of thesecond catheter 470 based on the information from the sensor. In some embodiments, a sensor can be disposed within thethird lumen 476 of thesecond catheter 470 that can be configured to determine a flow rate of irrigation and/or a biological/therapeutic agent therethrough. - In some embodiments, radiopaque markers of gold or tantalum, for example, can also be provided on or in an inner catheter positioned, within or on an occlusion element(s) (e.g., the
occlusion elements catheter devices - In some embodiments, an outer diameter of an outer catheter (e.g., the
second catheters occlusion elements - In some embodiments, after a guidewire (e.g., the
guidewire 280 and/or 380) is removed, a corresponding lumen (e.g., thesecond lumen first catheter - In some embodiments, any suitable configuration of the catheter devices can be used to achieve the objectives described herein including, for example, employing one or
more catheter devices - In some embodiments, to allow endovascular isolation of the pancreatic portion of the splenic artery 40 (see e.g.,
FIG. 1 ) as a mechanism to achieve substantially exclusive delivery of a therapeutic agent/cells to the pancreatic parenchyma, a catheter device such as those described herein can include anatomical and mechanical features such as, for example, isolation of the two ends of the pancreatic portion of the artery using two occlusion elements; adjustment of the diameter of the occlusion elements to meet the specific anatomical needs; adjustment of the distance between the two occlusion elements (based on individual variation to selectively isolate for instance the portion of thesplenic artery 40 to thepancreas 30 on one hand and maximize the perfusion area on the other hand); an infusion port where injection of contrast can be used to visualize the area of the artery isolated; an infusion port, shaft, and/or aperture design to allow atraumatic and rapid delivery of cells/therapeutic agents; and/or recovery of the occlusion element along with the catheter at the end of the procedure, prior to which flushes through the infusion port can assure clearance of the cells from the isolated space. - In some instances, any portion of the
catheter devices infusion apertures pancreas 30, in some instances, thecatheter device second catheter 470 relative to thepancreas 30. Thus, theinfusion aperture second catheter infusion aperture catheter device infusion aperture infusion aperture - Any catheter device described herein and/or any combination of the catheter devices described herein can allow the above goals to be achieved. For example, a catheter device can include two catheters slidably coupled where an inner catheter defines a guidewire housing port and a distal occlusion element, and an outer catheter forms an infusion port and a proximal occlusion element, along with an inner lumen allowing the insertion of the inner catheter. The two catheters can be assembled outside the body with a distance between the two occlusion elements set to a desired length. For example, in some embodiments, the minimum distance between the two occlusion elements can be 3 cm, and the length can be adjusted up to a distance between the two occlusion elements of 25 cm as needed.
- In some embodiments, a catheter device such as those described herein, which is suitable for accessing the pancreas 30 (see e.g.,
FIG. 1 ) can include features and/or functions, such as, for example, selective isolation of the targeted portion of the pancreatic portion of the splenic artery 40 for targeted delivery of the therapeutic agent to the pancreas 30; an adjustable distance between the two ends of the perfusion/infusion area (e.g., an isolated region) to accommodate individual anatomy to allow isolation of the largest portion of the splenic artery 40 with branches only supplying the pancreatic tail 32 and body 34 (see e.g.,FIG. 1 ) and if clinically indicated, the same catheter can be used to isolate portions of the hepatic artery 54 and/or superior mesenteric artery 52 supplying the head of the pancreas 38; an infusion port allowing first, injection of contrast into the isolated segment to allow direct visualization of the origin of the branches of the splenic artery 40 supplying the pancreatic tissue, and second, introduction of therapeutic drugs/cells, the dimensions and design of the infusion port and catheter shaft allowing rapid and atraumatic delivery of cells; adjustable diameter of the proximal and/or distal occluders to allow both intravariable and intervariable sizes of the splenic artery 40; and/or a self-contained assembly unit with easy retrieval after completion of the procedure. - While various embodiments have been described above, it should be understood that they have been presented by way of example only, and not limitation. Where schematics and/or embodiments described above indicate certain components arranged in certain orientations or positions, the arrangement of components may be modified. While the embodiments have been particularly shown and described, it will be understood that various changes in form and details may be made. Although various embodiments have been described as having particular features and/or combinations of components, other embodiments are possible having a combination of any features and/or components from any of embodiments as discussed above. For example, the size and specific shape of the various components can be different from the embodiments shown, while still providing the functions as described herein. Furthermore, each feature disclosed herein may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise. Thus, unless expressly stated otherwise, each feature disclosed is one example only of a generic series of equivalent or similar features.
- For example, although the
outer catheters catheter devices inner catheter inner catheter outer catheter catheter devices first catheter second catheter second catheter 270 and/or 370, the sealingelement 285 and/or 385 can alternatively be coupled to thefirst catheter 260 and/or 360. - Although the
catheter devices balloon elements 268 and/or 278) and one or more filter element occlusion elements (e.g., thefilter elements 368 and/or 378). - While various embodiments have been described above, it should be understood that they have been presented by way of example only, and not limitation. Where schematics and/or embodiments described above indicate certain components arranged in certain orientations or positions, the arrangement of components may be modified. While the embodiments have been particularly shown and described, it will be understood that various changes in form and details may be made. Although various embodiments have been described as having particular features and/or combinations of components, other embodiments are possible having a combination of any features and/or components from any of embodiments as discussed above. For example, the size and specific shape of the various components can be different from the embodiments shown, while still providing the functions as described herein. Furthermore, each feature disclosed herein may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise. Thus, unless expressly stated otherwise, each feature disclosed is one example only of a generic series of equivalent or similar features.
- Where methods and/or events described above indicate certain events and/or procedures occurring in certain order, the ordering of certain events and/or procedures may be modified. Additionally, certain events and/or procedures may be performed concurrently in a parallel process when possible, as well as performed sequentially as described above.
Claims (21)
1. (canceled)
2. A method of treatment, the method comprising:
inserting a catheter into a bile duct;
occluding the bile duct with a first occluder on a distal end region of the catheter and a second occluder on the distal end region of the catheter proximal to the first occluder, to isolate a region of the bile duct;
delivering a therapeutic agent into the isolated region of the bile duct; and
maintaining a pressure in the isolated region of the bile duct to diffuse the therapeutic agent into a tissue around the bile duct.
3. The method of claim 2 , wherein maintaining the pressure of the isolated region of the bile duct comprises delivering the therapeutic agent into the isolated region of the bile duct under pressure.
4. The method of claim 2 , further comprising increasing or decreasing the pressure in the isolated region of the bile duct to change a penetration depth of the therapeutic agent into the tissue around the bile duct.
5. The method of claim 2 , wherein the tissue around the bile duct comprises a tumor.
6. The method of claim 2 , wherein the tissue around the bile duct comprises one or more of: a pancreatic tumor, a liver tumor and a cholangiocarcinoma.
7. The method of claim 2 , wherein inserting the catheter comprises advancing the catheter over a guidewire within the bile duct.
8. The method of claim 2 , wherein inserting the catheter comprises inserting the catheter into the bile duct to a region of the bile duct that adjacent to a tumor.
9. The method of claim 2 , wherein inserting the catheter comprises inserting the catheter through an endoscopic retrograde cholangiopancreatogram (ERCP) catheter.
10. The method of claim 2 , wherein inserting the catheter comprises inserting the catheter percutaneously.
11. The method of claim 2 , wherein inserting comprises adjusting the distance between the first occluder and the second occluder by advancing the first occluder distally, wherein the first occluder is on an inner catheter slidably disposed within a lumen of the catheter.
12. The method of claim 2 , wherein occluding the bile duct comprises inflating the first occluder and the second occluder.
13. The method of claim 2 , wherein the therapeutic agent is selected from the group of: (5-fluorouracil (5-FU), Aldesleukin, Axitinib, Bleomycin, Carboplatin, Cetuximab, Cisplatin, Cyclophosphamide, Dacarbazine, Doxorubicin Hydrochloride, doxorubicin liposomal non-pegylated (un-coated), doxorubicin liposomal pegylated (PEG coated), Floxuridine, Gemcitabine Hydrochloride, Irinotecan Hydrochloride Liposome, Lanreotide Acetate, leucovorin (antidote to folic acid antagonist used with 5FU), Methotrexate, Mitomycin, Mitoxantrone, Nivolumab, Olaparib, Oxaliplatin, Sorafenib Tosylate, Temsirolimus, Thiotepa, Topotecan Hydrochloride, Vinblastine Sulfate, vincristine sulfate).
14. A method of treatment, the method comprising:
inserting a catheter into a bile duct to a region of the bile duct that adjacent to a tumor;
isolating a region of the bile duct adjacent to the tumor by occluding the bile duct with a first occluder on a distal end region of the catheter and a second occluder on the distal end region of the catheter proximal to the first occluder;
introducing a therapeutic agent into the isolated region of the bile duct from out of an opening in a side wall of the catheter between the first occluder and the second occluder; and
diffusing the therapeutic agent into a tissue around the bile duct by maintaining the pressure in the isolated region of the bile duct at greater than an interstitial tissue pressure in the tissue around the bile duct.
15. The method of claim 14 , further comprising increasing or decreasing the pressure in the isolated region of the bile duct to change a penetration depth of the therapeutic agent into the tissue around the bile duct.
16. The method of claim 14 , wherein the tumor comprises one or more of: a pancreatic tumor, a liver tumor and a cholangiocarcinoma.
17. The method of claim 14 , wherein inserting the catheter comprises advancing the catheter over a guidewire within the bile duct.
18. The method of claim 14 , wherein inserting the catheter comprises inserting the catheter through an endoscopic retrograde cholangiopancreatogram (ERCP) catheter.
19. The method of claim 14 , wherein inserting comprises adjusting the distance between the first occluder and the second occluder by advancing the first occluder distally, wherein the first occluder is on an inner catheter slidably disposed within a lumen of the catheter.
20. The method of claim 14 , wherein the therapeutic agent is selected from the group of: (5-fluorouracil (5-FU), Aldesleukin, Axitinib, Bleomycin, Carboplatin, Cetuximab, Cisplatin, Cyclophosphamide, Dacarbazine, Doxorubicin Hydrochloride, doxorubicin liposomal non-pegylated (un-coated), doxorubicin liposomal pegylated (PEG coated), Floxuridine, Gemcitabine Hydrochloride, Irinotecan Hydrochloride Liposome, Lanreotide Acetate, leucovorin (antidote to folic acid antagonist used with 5FU), Methotrexate, Mitomycin, Mitoxantrone, Nivolumab, Olaparib, Oxaliplatin, Sorafenib Tosylate, Temsirolimus, Thiotepa, Topotecan Hydrochloride, Vinblastine Sulfate, vincristine sulfate).
21. A method of treatment, the method comprising:
inserting a catheter into a bile duct to a region of the bile duct that adjacent to a tumor;
isolating a region of the bile duct adjacent to the tumor by occluding the bile duct with a first occluder on a distal end region of the catheter and a second occluder on the distal end region of the catheter proximal to the first occluder;
injecting a therapeutic agent into the isolated region of the bile duct from out of an opening in a side wall of the catheter between the first occluder and the second occluder so that the pressure in the isolated region of the bile duct is greater than an interstitial tissue pressure in a tissue around the bile duct, whereby the therapeutic agent diffuses into the tissue around the bile duct.
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US17/558,577 Active US11541211B2 (en) | 2009-12-02 | 2021-12-21 | Methods for delivery of therapeutic materials to treat cancer |
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US11541211B2 (en) | 2009-12-02 | 2023-01-03 | Renovorx, Inc. | Methods for delivery of therapeutic materials to treat cancer |
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US11541211B2 (en) | 2023-01-03 |
US20230355934A1 (en) | 2023-11-09 |
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US20170056629A1 (en) | 2017-03-02 |
US10512761B2 (en) | 2019-12-24 |
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