US20190076391A1 - Methods of Subtyping CRC and their association with Treatment of Colon Cancer Patients With Oxaliplatin

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Abstract

Description

Claims

US20190076391A1

Publication number: US20190076391A1
Application number: US16/184,748
Authority: US
Inventors: Katherine Lea Pogue-Geile; Nan Song; Soonmyung Paik
Original assignee: NSABP Foundation Inc
Current assignee: NSABP Foundation Inc
Priority date: 2014-06-12
Filing date: 2018-11-08
Publication date: 2019-03-14
Also published as: US20150366835A1; US10166210B2

A gene expression signature identifies stage II colon and/or Stage III cancer patients who will receive benefit from oxaliplatin. Oxaliplatin has been shown to lengthen the survival of colon cancer patients, when it is combined with 5-fluorouracil plus leucovorin (FULV) in NSABP clinical trial C-07. Gene expression signatures are used first to classify tumors with regard to their respective subtypes, enterocyte, TA, goblet, inflammatory and stem-like and detection of expression of the enterocyte subtype directs treatment of the patient with oxaliplatin.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a continuation of and claims the benefit of priority of U.S. patent application Ser. No. 14/738,757, filed Jun. 12, 2015, and further claims benefit of priority to U.S. provisional patent application Ser. No. 62/011,571 filed Jun. 12, 2014, the entire contents of both of which are incorporated herein by reference for all purposes.

BACKGROUND

Clinical trials MOSAIC (Andre, Boni et al. 2009)¹(Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin trial) and C-07 (Kuebler, Wieand et al. 2007)²showed that oxaliplatin added to fluorouracil (FU) and leucovorin (LV) significantly improved disease free survival (DFS) and established oxaliplatin as part of the standard of care for the adjuvant treatment of early-stage colon cancer. In the C-07 trial, 2,409 patients diagnosed with stage II and III colon adenocarcinoma who had undergone potentially curative surgical resection with no evidence of residual malignant disease were randomly assigned to receive either FULV (FU 500 mg/m2 by intravenous [IV] bolus weekly for 6 weeks; leucovorin 500 mg/m2 IV weekly for 6 weeks of each 8-week cycle for three cycles) or FLOX (FULV plus oxaliplatin 85 mg/m2 IV on days 1, 15, and 29 of each cycle). Based on the 2011 analysis with median follow-up of 8 years, FLOX demonstrated superior DFS (HR: 0.82; P=0.002)(Kuebler, Wieand et al. 2007)². Current NCCN guidelines recommend that all stage III patients, and high risk stage II patients be treated with oxaliplatin. High risk stage II includes patients with perforation, or obstruction or tumors with lymphovascular or perineural invasion, T4 lesions, less than 12 Lymph nodes examined, or grade 3-4 lesions. However, recent analysis of MOSAIC analysis found no statistically significant benefit for either all stage II or high risk stage II patients (Tournigand, Andre et al. 2012)³. The use of oxaliplatin in all early stage colon cancer patients remains controversial not only because it is uncertain which patients actually receive benefit but also because of the toxic side effects associated with oxaliplatin (Cersosimo 2005)⁴. Thus, stratifying patients with regard to their oxaliplatin benefit is of significant clinical interest.
Recently, several studies (De Sousa, Wang et al. 2013; Marisa, de Reynies et al. 2013; Sadanandam, Lyssiotis et al. 2013)^6-8have used unsupervised clustering methods to develop genomic signatures to classify colorectal cancer to different intrinsic subtypes and showed that each subtype has distinct molecular features, clinical significance and prognosis. These groups identified either 3 or 5 intrinsic subtypes with the CCS3, Stem-Like as the poorest prognostic group. The different number of clusters in these publications is not surprising given that different methods and different training datasets were used. Sadanandam et al's (Sadanandam, Lyssiotis et al. 2013)⁹five subtypes were correlated to gene expression patterns of the different cell types located within the normal colonic crypts. De Sousa et al also demonstrated that most of the published gene expression based prognostic assays identify essentially the same group of tumors (mostly stem-like or CCS3 subtypes) as those associated with high risk of relapse. Given that it is now well established that breast cancer subtypes differ regarding their prognosis and their response to treatment, it was reasonable to hypothesize that the clinical behavior of the different colon subtypes may also differ with respect to prognosis and importantly with response to treatment. However, it was not possible to test treatment response in these published studies because the patient cohorts were treated with a variety of agents and were not part of a randomized clinical trial designed to test a particular agent. In contrast the gene expression data which was profiled on archived tumor blocks from NSABP clinical trial C-07 represented an ideal experimental cohort to test whether colon cancer subtypes could be used to predict oxaliplatin benefit. Before the publication of these colon cancer subtypes we had completed the gene expression profiling of 1846 patients from C-07 using our custom nCounter code set using nCounter assays from Nanostring Technologies.

SUMMARY

The initial study described here provides a gene expression signature which identifies stage II and III colon cancer patients who will receive benefit from oxaliplatin. Oxaliplatin has been shown to lengthen the survival of colon cancer patients, when it is combined with 5-fluorouracil plus leucovorin (FULV) in NSABP clinical trial C-07. However, mounting evidence suggest that not all early stage colon cancer patients benefit from oxaliplatin treatment and the toxicities associated with oxaliplatin highlights the importance of identifying patients who will actually receive benefit from oxaliplatin treatment. We have used gene expression signatures to first classify tumors in C-07 with regard to their respective subtypes, enterocyte, TA, goblet, inflammatory and stem-like and shown that only the enterocyte subtype received benefit from oxaliplatin. Comparing the benefit in the enterocyte subtype to a second group consisting of all four other subtypes, (Goblet-like, Inflammatory, Stem-like and TA) as a non-benefit group, showed a significant treatment-group interaction (p=0.012). In a second step we showed that the stem-like subtype can be further sub-typed into patients who do and do not receive benefit from oxaliplatin. Identification of this sub-subtype which received benefit from oxaliplatin is also of clinical interest in that the stem-like subtype has a very poor prognosis.
We have profiled 296 genes in 1840 patients from NSABP clinical trial C-07 using a custom nCounter code set using the nCounter Assay system from Nanostring Technologies (Seattle Wash.). Genes selected for inclusion on our custom nCounter code set were a result of our own gene expression analysis of the C-07 discovery cohort or other published studies. Gene expression profiling was conducted on tumor blocks from patients with follow-up information and proper consent. Samples within C-07 were split into non-overlapping discovery (N=848) and validation cohorts (N=992). The current description involves only the use of the discovery cohort. Clinical data and nCounter data for the discovery dataset were merged and anonymized by the honest broker at the University of Pittsburgh as defined by standard operations under IRB approval of the NSABP Biospecimen Bank and Biostatistics Center.
We have developed a predictive algorithm to classify tumors into oxaliplatin benefit or no benefit group using discovery cohort of 848 patients without access to the data from the remaining 992 patients (validation cohort). The nCounter genes used for this analysis are 72 genes included in both our custom nCounter code set (N=296) and in the intrinsic subtype signature described by Sadanandam et al. (Sadanandam, Lyssiotis et al. 2013)
The current disclosure can be described therefore as a method for treating colon cancer in a patient in need thereof said method comprising obtaining a tumor tissue sample from said patient; determining a gene expression signature of said sample; identifying a tumor tissue subtype from said gene expression signature; and administering oxaliplatin when the identified tumor tissue subtype is an oxaliplatin responsive subtype. As used herein subtype can refer to one of five colon cancer subtypes, enterocyte, TA, goblet, inflammatory and stem-like, and sub-subtype can refer to a division within one of the 5 subtypes that is more enterocyte-like or that is more responsive to oxaliplatin, for example, than other genes within the subtype.
The methods can be further described therefore as determining a gene expression signature by steps including contacting a genetic sample from the tumor tissue sample with a plurality of specific genetic sequence binding targets and measuring the amount of genetic material expressed by the tumor tissue for a panel of selected genes, wherein the panel of genes are selected from those listed in Table 5. A gene binding target can be a polynucleotide, a protein, a peptide or a peptide nucleic acid, and as such can be synthesized based on a complementary sequence or on a synthetic molecule designed to specifically bind to the RNA. The sample or the target can be affixed to a solid surface such as a planar surface, contained in or affixed to a bead or contained in an oil droplet, for example, or in other forms known in the art such as but not limited to next-generation sequencing technologies such as RNA-Seq or whole transcriptome sequencing.
In certain preferred embodiments the genetic sample comprises degraded or intact RNA and can be mRNA or total RNA or whole tissue lysates from selected genes from Table 5. In certain embodiments the panel of genes for determination of a gene signature are selected by a process that includes Weighted Gene Correlation Network Analysis (WGCNA), to identify members of oxaliplatin responsive gene modules.
Disclosed methods of treatment include administration of oxaliplatin is administered in combination with 5-fluorouracil plus leucovorin (FULV), and can include administration to a stage II or stage III colon cancer patient. The tumor sample can be subtype enterocyte or TA or a sub-subtype of enterocyte or TA. In certain embodiments cancer tumor sample is subtype stem-like or a sub-subtype of stem-like.
The disclosure can also be described in certain embodiments as method for treating colon cancer in a patient in need thereof said method comprising: obtaining a tumor tissue sample from said patient; isolating RNA from the tumor tissue sample; contacting the RNA sample with a plurality of sequence specific probes effective to determine levels of expression of a panel of selected genes in the tumor sample to obtain a gene signature; identifying a colon cancer subtype or sub-subtype tumor subtype based on the gene signature; and administering oxaliplatin or causing oxaliplatin to be administered to said patient when the cancer subtype or sub-subtype is an oxaliplatin responsive subtype or sub-subtype. Gene specific probes can include complementary nucleic acid sequences or other probes that do not necessarily bind to a site within the gene such as those used for Next-generation sequencing technologies which quantitate RNA by sequencing RNA molecules directly, for example.
The method can include utilizing a panel of selected genes are selected from the genes listed in Table 5. The methods can further include administering oxaliplatin or causing oxaliplatin to be is administered in combination with 5-fluorouracil plus leucovorin (FULV) to a stage II or stage III colon cancer patient, where the patient's tumor tissue is determined to be subtype enterocyte or TA or a sub-subtype of enterocyte or TA, or subtype stem-like or a sub-subtype of stem-like.

BRIEF DESCRIPTION OF THE DRAWINGS

The following drawings form part of the present specification and are included to further demonstrate certain aspects of the present inventions. The disclosure can be better understood by reference to one or more of these drawings in combination with the detailed description of specific embodiments presented herein.

FIG. 1 Design of Study for discovery and validation of a signature to identify patients who will benefit from oxaliplatin. In this description only the discovery cohort has been used for signature development.

FIG. 2 shows the steps that were taken to develop predictive algorithm using nCounter data from the discovery cohort of C-07.

FIG. 3 Kaplan Meier Plots of each CRC subtype using our gene signature by CRC-SSP-72 according to treatment (FULV versus FOLFOX) using recurrence free survival (RFS) as the end point. Among identified CRC subtypes, only Enterocyte received significant benefit (HR=0.315, p=0.005).

FIG. 4 Kaplan Meier Plots of the Enterocyte subtype and of all of the other subtypes (Goblet-like, Inflammatory, Stem-like and TA) combined into one group (Others) There is significant treatment-group interaction (p=0.012)

FIG. 5 Reproducibility of a C07 sample (C-07-0286) measured by nCounter. This sample was tested using 100, 150, 200, and 250 ng of total RNA as input.

FIG. 6 Venn diagram of genes used for developing subtype classifiers.

DETAILED DESCRIPTION

The present invention provides methods for identifying tumors which are responsive to oxaliplatin in individuals. The methods involves the gene expression analysis of RNA isolated from tissue or other biological sources such as blood, urine or feces using nCounter Assays from Nanostring Technologies Inc, or other gene expression methodologies such as microarray, RNA-Seq, hybrid capture RNA sequencing or other state of the art RNA expression profiling methodologies, identifying the colon cancer intrinsic subtypes, identifying the subtypes that received benefit from oxaliplatin. As used herein isolated RNA is meant to convey any separation of RNA from its environment in a cell, including any fractionation, binding, filtration, degradation or even cell rupture such as a lysate.
Clinical Samples and Histological Evaluation Used in this Description.
Samples used in this disclosure were from NSABP clinical trial C-07. This trial enrolled patients between February 2000 and November 2002 to compare oxaliplatin and bolus 5-FU/LV to bolus 5 FU/LV alone for resected stage II and III colon cancer². C-07 was approved by an Institutional Review Board and informed consent was obtained from each subject for biomedical research.
I. nCounter Assays Used to Determine Gene Expression
The nCounter platform by Nanostring Technologies was used to profile gene expression in RNAs isolated from tumors collected in NSABP clinical trial C-07 which is an ideal platform for a clinical assay for chemically modified and degraded RNAs isolated from FFPE because it requires no enzymology, requires small amounts of total RNA, capture and detection probes target less than 100 bp sequence, and the process is largely automated requiring little hands on time.
The C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes. The 296 genes included in this nCounter code set were selected for the following reasons; the genes were prognostic or predictive for oxaliplatin benefit in the C-07 discovery cohort using whole genome DASL arrays (WG_DASL) from Illumina Inc or were part of significant pathways identified in C07 DASL data analysis or were from the literature or other internal data.
We have profiled 296 genes in 1840 patients using the nCounter Assay system (Nanostring Technologies, Seattle Wash.). Clinical data and nCounter data for the discovery dataset were merged and anonymized by the honest broker at the University of Pittsburgh as defined by standard operations under IRB approval of NSABP Biospecimen Bank and Biostatistics Center. We have developed a predictive algorithm to classify tumors into oxaliplatin benefit or no benefit group using discovery cohort of 848 patients without access to the data from the remaining 992 patients (validation cohort).

II. Study Design

For C07, 2409 patients were enrolled in C-07 and all cases with tumor blocks, proper consent, clinical follow-up information and sufficient RNA yields were used in this study (N=1840). These cases were split into a discovery (N=848) and a validation (N=992) cohort (FIG. 1). The present signature was developed with the discovery cohort.
A. Intrinsic Subtype and Oxaliplatin Benefit:
The steps for signature development are summarized in FIG. 2.
With the goal of developing genomic predictive biomarker for oxaliplatin benefit, we first identified intrinsic subtypes and tested oxaliplatin benefit in each subtype. The disclosed methods focused on the CRC intrinsic subtypes identified by Sadanandam⁶, and the CCS intrinsic subtypes identified by De Sousa⁷. Since nCounter assay was designed before the publication of the above papers, only a small proportion of intrinsic genes were matched to genes included in the nCounter assay. For example, for the CRC study⁶, among 1262 non-specific filtered genes, only 72 exist in the nCounter code dataset, and among 786 identified intrinsic subtyping genes, only 56 exist in the nCounter code dataset. Our analysis indicated that subtype can be identified with a subset of 786 genes. Based on the 56 genes, using SSP method, specifically, we checked the Spearman correlation between each sample and the subtype centroid, and then assigned each sample to the subtype to which it was most correlated. This method correctly identified subtype in 79% of the samples.
To improve the robustness of subtype identification, we redeveloped centroid for each subtype based on the 72 genes that overlap between C-07 nCounter code dataset and the original CRC training dataset. We then applied SSP method to the C-07 training dataset, i.e., we checked the Spearman correlation between each sample and the subtype centroid using the 72 genes (Table 1), then assigned each sample to the most correlated subtypes. We can correctly identify the subtype in 80% of the samples (Table 2). Clinical variables such as T stage, nodal status perforation and mutation status of BRAF, KRAS, NRAS and PIK3CA of each subtype are shown in Table 3.

TABLE 1

Centroid of CRC-SSP-72.

	Enterocyte	Goblet.like	Inflammatory	Stem-like	TA

AKAP12	−0.1564	−0.3258	−1.00E−04	0.6652	−0.1946
ANKRD44	0.0701	−0.1685	0.2335	0.0874	−0.1798
BGN	−0.2625	−0.3363	0.1203	0.684	−0.2285
BHLHE41	0.1079	0.075	0.0015	0.2663	−0.3092
BMP7	−0.2046	−0.0645	−0.143	0.04	0.2408
C8orf84	−0.4073	0.5791	−0.0724	−0.1541	0.0682
CAB39L	−0.0904	−0.2837	−0.4717	0.1316	0.4798
CDKN2B	0.6162	−0.4035	−0.0118	0.222	−0.2867
CKMT2	0.0206	−0.2473	−0.2254	−0.0649	0.3515
COL11A1	−0.4436	−0.3797	0.189	0.7476	−0.1898
COMP	−0.4057	−0.202	−0.1175	0.7747	−0.1101
CPE	0.091	0.1071	−0.4766	0.2741	0.0311
CSGALNACT1	−0.2585	−0.0478	−0.0254	0.2363	0.0324
CXCL10	−0.1897	−0.1776	0.7137	−0.0052	−0.302
CXCL11	−0.203	−0.115	0.6691	−0.0649	−0.2545
CXCL13	0.11	−0.2356	0.8126	−0.1015	−0.4541
CXCL2	−0.1416	0.0466	0.1917	−0.2284	0.0826
CXCL9	−0.2303	−0.2078	0.7334	−0.006	−0.2731
CYP1B1	−0.3509	−0.242	0.0875	0.8449	−0.3248
DAPK1	−0.2495	0.3342	0.3441	0.1757	−0.4336
DCBLD2	−0.2662	−0.1791	0.1036	0.335	−0.0522
DPEP1	−0.1993	0.0196	−0.4644	−0.0446	0.4881
EPB41L4B	0.1808	−0.0063	−0.2888	−0.3419	0.3594
ERAP2	−0.0712	0.0416	0.4002	−0.1821	−0.1445
F5	−0.2002	0.0195	0.2094	−0.0196	−0.03
FAP	−0.2881	−0.2525	0.1586	0.6969	−0.301
FGL2	0.1732	−0.1883	0.3211	0.1058	−0.3093
FN1	−0.2859	−0.4114	0.1302	0.5476	−0.0764
FNDC1	−0.2566	−0.3827	−0.0213	0.8409	−0.2125
GBP1	−0.1684	−0.2325	0.6939	0.0308	−0.2952
GBP4	−0.1999	−0.1174	0.7101	−0.1899	−0.1937
GPX3	0.0253	−0.1816	−0.0432	0.4493	−0.203
GRM8	−0.0273	−0.1092	−0.3808	−0.2021	0.5153
GZMB	−0.2513	−0.4275	0.3314	−0.167	0.2865
HGD	0.2535	0.3355	−0.0656	−0.3365	−0.0593
HOXA13	−0.0301	0.1091	−0.0917	−0.2152	0.1795
HSD17B2	0.6687	−0.0054	0.1407	−0.3991	−0.2153
ID4	−0.1789	0.0325	−0.2977	0.4248	0
IDO1	−0.2064	−0.1664	0.7754	−0.2062	−0.1969
IL8	−0.166	−0.0459	0.3226	0.0624	−0.156
INHBA	−0.3224	−0.2377	0.1021	0.6646	−0.2233
MFAP5	1.00E−04	−0.3641	−0.1964	0.8067	−0.2264
MGP	0.0509	−0.4134	−0.1745	0.8961	−0.3097
MMP11	−0.1743	−0.2439	−0.1581	0.462	0.0318
MMP28	0.4253	0.2425	0.1082	−0.1931	−0.3441
NFIB	0.0535	−0.0317	−0.5168	0.0032	0.3672
OAS2	−0.1136	0.0199	0.4392	−0.0611	−0.2234
PAPPA	−0.0641	−0.2033	0.0437	0.3593	−0.1342
PIGR	0.2984	0.2771	0.2527	−0.4536	−0.2038
PLA2G12B	−0.0591	−0.2634	−0.3123	−0.1001	0.5015
POU2AF1	0.3543	0.2138	0.147	−0.1889	−0.3155
PRAP1	−0.0074	−0.2188	−0.4551	0.0767	0.4181
PROM2	0.2046	0.1593	−0.0655	−0.2981	0.0462
PSMB9	−0.1726	−0.0019	0.4983	−0.2105	−0.1072
PTPRC	0.0416	−0.252	0.5649	0.1694	−0.4187
ROBO1	−0.1221	−0.2991	0.0818	0.2661	−0.0014
SDC2	−0.0982	−0.2924	−0.0399	0.5358	−0.1257
SELL	0.0788	−0.1222	0.2456	0.0016	−0.1589
SERPINE1	−0.1613	−0.116	0.0757	0.3678	−0.1574
SFRP2	−0.2103	−0.5022	0.0497	1.0716	−0.3926
SGK2	0.2445	−0.2138	−0.4084	−0.2707	0.4818
SLC4A4	1.099	0.1349	0.0933	−0.461	−0.4826
SPARC	−0.1227	−0.3431	0.0146	0.6662	−0.218
SPP1	−0.3134	−0.1681	0.4032	0.4321	−0.3238
SSPN	−0.0575	−0.0801	−0.1318	0.5308	−0.206
STC1	−0.3185	−0.1163	0.2305	0.2822	−0.1135
TACSTD2	−0.0954	0.2113	−0.0379	0.109	−0.1196
TGFBR3	−0.1721	−0.0829	−0.016	0.04	0.1378
TM4SF1	−0.1527	−0.1754	−0.0883	0.0963	0.1938
TYMS	−0.1895	0.1904	0.4728	−0.3805	−0.0701
VCAN	−0.1637	−0.3038	−0.0031	0.7104	−0.2344
VNN1	0.0753	0.2341	0.4957	−0.2096	−0.4016

TABLE 2

Consistency between CRC-SSP-72 and original
algorithm in identifying CRC subtypes.

Truth

	Goblet-		Stem-
Enterocyte	like	Inflammatory	like	TA

Prediction

Enterocyte

TABLE 3

Patient characteristics by intrinsic subtype identified by CRC-SSP-72.

		Enterocyte	Goblet-like	Inflammatory	Stem-like	TA

Gender	F	43 (47.3%)	22 (34.9%)	89 (44.1%)	95 (39.7%)	79 (43.2%)
	M	48 (52.7%)	41 (65.1%)	113 (55.9%)	144 (60.3%)	104 (56.8%)
Stage	II	26 (28.6%)	20 (31.7%)	88 (43.6%)	57 (23.8%)	42 (23%)
	III	65 (71.4%)	43 (68.3%)	114 (56.4%)	182 (76.2%)	141 (77%)
Grade	Diff	80 (87.9%)	51 (81%)	126 (62.4%)	194 (81.2%)	168 (91.8%)
	undiff	11 (12.1%)	12 (19%)	76 (37.6%)	45 (18.8%)	15 (8.2%)
TStage	T12	15 (16.5%)	11 (17.5%)	17 (8.4%)	7 (2.9%)	28 (15.3%)
	T3	71 (78%)	46 (73%)	176 (87.1%)	213 (89.1%)	144 (78.7%)
	T4	5 (5.5%)	6 (9.5%)	9 (4.5%)	19 (7.9%)	11 (6%)
Perforation	0	89 (97.8%)	62 (98.4%)	196 (97%)	231 (96.7%)	179 (97.8%)
	1	2 (2.2%)	1 (1.6%)	6 (3%)	8 (3.3%)	4 (2.2%)
Nodes positive	0	26 (28.6%)	20 (31.7%)	88 (43.6%)	57 (23.8%)	42 (23%)
detected	1-3	43 (47.3%)	32 (50.8%)	78 (38.6%)	107 (44.8%)	108 (59%)
	4+	22 (24.2%)	11 (17.5%)	36 (17.8%)	75 (31.4%)	33 (18%)
MSI status	MSS	77 (100%)	50 (87.7%)	131 (72.4%)	193 (94.1%)	162 (97.6%)
	MSI	0 (0%)	7 (12.3%)	50 (27.6%)	12 (5.9%)	4 (2.4%)
BRAFmutated	w	83 (91.2%)	48 (78.7%)	145 (72.9%)	205 (86.1%)	177 (96.7%)
	m	8 (8.8%)	13 (21.3%)	54 (27.1%)	33 (13.9%)	6 (3.3%)
KRASmutated	w	64 (71.9%)	26 (44.1%)	129 (66.8%)	126 (54.1%)	121 (66.9%)
	m	25 (28.1%)	33 (55.9%)	64 (33.2%)	107 (45.9%)	60 (33.1%)
METmutated	w	85 (96.6%)	56 (94.9%)	184 (95.3%)	227 (97.4%)	174 (96.1%)
	m	3 (3.4%)	3 (5.1%)	9 (4.7%)	6 (2.6%)	7 (3.9%)
NRAS mutated	w	85 (96.6%)	56 (94.9%)	190 (99%)	226 (97%)	176 (97.2%)
	m	3 (3.4%)	3 (5.1%)	2 (1%)	7 (3%)	5 (2.8%)
PIK3CAmutated	w	74 (84.1%)	46 (76.7%)	142 (73.2%)	175 (74.8%)	158 (87.3%)
	m	14 (15.9%)	14 (23.3%)	52 (26.8%)	59 (25.2%)	23 (12.7%)
RFI Status	0	59 (64.8%)	47 (74.6%)	173 (85.6%)	141 (59%)	132 (72.1%)
	1	32 (35.2%)	16 (25.4%)	29 (14.4%)	98 (41%)	51 (27.9%)
OS Status	0	54 (59.3%)	40 (63.5%)	156 (77.2%)	138 (57.7%)	121 (66.1%)
	1	37 (40.7%)	23 (36.5%)	46 (22.8%)	101 (42.3%)	62 (33.9%)

As shown in FIG. 3, among identified CRC subtypes, only Enterocyte received significant benefit (HR=0.315, p=0.005). In combining all other four subtypes, Goblet-like, Inflammatory, Stem-like and TA as a non-benefit group, there is significant treatment-group interaction (p=0.012) (FIG. 4). However when stage II and III CRC patients were tested separately only stage III patients showed differential benefit from oxaliplatin when subtyped with our 72 gene signature (FIG. 5).
Similarly, we also identified CCS colon cancer subtypes which include CCS1, CCS2 and CCS3⁷. Consistent with other studies¹¹, the CRC clustering and CCS clustering are correlated with each other, i.e., most CCS1 patients are TA or Enterocyte patients, most CCS2 patients are inflammatory and most CCS3 are stem-like patients. Since CCS did not separate Enterocyte which received significant benefit from oxaliplatin from other TA patients, we decided to use SSP-72 to identify CRC subtypes.
III. RNA Expression Profiling Using nCounter Assay System
Gene Expression Profiling by nCounter Assay System:
The nCounter platform was selected as the platform for a clinical assay for degraded RNAs isolated from FFPE because it requires no enzymology, requires only 100 to 300 ng of total RNA, capture and detection probes target less than 100 bp sequences, and the process is largely automated requiring little hands on time. The C-07 customized nCounter code set consisted of 296 genes plus 6 positive and 8 negative technical control genes. The 296 genes included in this nCounter code set were selected for the following reasons; the genes were prognostic or predictive for oxaliplatin benefit in the C07 discovery cohort using DASL data or were part of significant pathways identified in C07 DASL data analysis or were from the literature.
nCounter Assay Data Processing
QC of the nCounter Assay Data.
Quality control of the data was performed using default flags in the NSolver software that is provided by the manufacturer:

- 1) Imaging flag—sample removed if less than ¾ of the expected fields of view are captured by the camera (0.75*600=450 minimum FOVs)
- 2) Binding Density—sample removed if the binding density falls outside the range 0.05-2.25
- 3) Positive Control Flag—sample removed if the positive spikes do not follow the expected linear trend (r̂2<0.95)
- 4) 0.5 fm Detection Flag—sample removed if the 0.5 fm positive control is within two standard deviations of the negative controls
- 5) Tech Normalization Flag—for the raw data, median(sum(pos(controls))/sum(positive control); sample removed if the technological normalization factor >3 or <0.3
- 6) Biological Normalization Flag—after adjusted by technical normalization, median (geomean(pos(house-keeping control s))/geomean(house-keeping control); sample removed if the biological normalization factor <0.1 or >10. In this data, KIAA1539, MADD, RAB1A, C17orf79, PDCD10, NFYC were selected as house-keeping genes.
- 7) If repeated measurements for an individual both pass above criteria, the lane with the lesser total counts will be removed

With the above criteria, 778 out of 848 samples (91.75%) pass QC and were used for signature development.

1. Nanostring Data Normalization

After preprocessing data, we normalized each tumor for technical variability with the sum of the positive controls inherent to nCounter assay and within sample reference normalized with the geometric mean of 6 internal reference genes (KIAA1539, MADD, RAB1A, C17orf79, PDCD10, NFYC).
2. Analytical Performance of mRNA Expression Profile by nCounter:
Dynamic range and limit of detection for the nCounter assay can be estimated from synthetic spike-in controls included with every sample. Positive controls are spiked into the reaction at concentrations from 0.125-128 fM, representing a fold-change of 1024. Measurements of these controls are highly linear (median r²=0.99 across all discovery samples) in this range. Eight negative control probes, representing sequences not found in the human transcriptome, are also included in each reaction. The lowest positive control, 0.125 fm, represents approximately 0.2 copies per cell, and is detected at least 2 standard deviations above the mean of the negative controls. If r²for the positive spikes drops below 0.95 or the 0.125 fm spike is not detected 2 standard deviations above the mean of the negative controls, the reaction is considered failed and that sample is repeated or removed from further analysis.
We also tested 11 pairs of samples as duplicate. For these duplicate samples, we calculated the correlation coefficients for the gene expression, the minimum of correlation coefficient is 0.9912, and mean is 0.9925, standard deviation is 0.0021.
To address assay reproducibility and required amount of input RNA, we first performed several samples using 100, 150, 200, and 250 ng of total RNA as input. Results for one representative sample are shown in FIG. 5. The raw data demonstrates an almost linear increase in signal with increased input material. However, normalized data were nearly identical demonstrating that we can use 100 ng of total RNA as the starting material for the nCounter assay.
In the C-07 discovery cohort the enterocyte subtype in CRCA subtype received benefit from oxaliplatin; however, this signature failed to validate in the independent data set. One reason that the signature failed to validate, may be due to the non-optimal identification of the enterocyte subtype. Our nCounter code set was created before the CRCA subtypes were described and therefore was not designed for subtype identification and unfortunately only includes a very small number of genes for enterocyte identification. Thus accurate identification of the enterocyte subtype was not optimal with the current code set
Another potential problem that may have contributed to the failure to validate our signature was the possibility that other subtypes could include patients who benefited from oxaliplatin. For example the stem-like and TA subtypes may need to be further split into sub-subtypes. TA is a heterogeneous group which has a gene expression pattern similar to transit-amplifying progenitor cells which differentiate into goblet and enterocyte cells in the normal colonic crypt. Thus TA may be further refined into sub-subtypes based on their future potential fate, i.e., TA cells that are more likely to differentiate into enterocytes and those that differentiate into goblet. We would hypothesize that only the enterocyte-like subtype within TA would receive benefit from oxaliplatin. However, because our nCounter code set only includes a small number of genes for enterocyte and goblet-like identification, we could not exploit this hypothesis in the nCounter data. We also attempted to split the stem-like subtype but were unable to find a satisfactory split for oxaliplatin benefit in this subtype.
As discussed above, the basis of our previous work is that subtypes have different molecular properties, which determine the degree of benefit they receive from treatment. However, because the identification of CRC subtypes is still in an exploratory phase, it is uncertain how to best identify relevant subtypes for oxaliplatin benefit.
Disclosed herein are a description of the genes and methods for identifying the association of gene modules with CRC subtypes and their association with clinical behavior with an emphasis on identifying patients who receive benefit from oxaliplatin. Identification of modular gene sets and their association to particular CRC subtypes allows not only for subtype identification but also a description of those subtypes, how they are similar and how they are different which will enable a better understanding of clinical behavior.
In the second study, we took a well-established systematic approach, Weighted Gene Correlation Network Analysis (WGCNA), to identify gene modules, i.e., correlated gene expression networks and evaluated how these modules are related to subtypes. Gene modules are generally comprised of functionally related genes. Understanding the gene modules which characterize subtypes will enable us to understand how each subtype is correlated to each other, and the molecular mechanisms of different prognostic or predictive behavior of each subtype. We have selected genes for a new code set which will enable us to better identify functional, clinically relevant CRC subtypes.
Additional studies profile C-07 with this new code set which provides better understanding of how each module is related to oxaliplatin benefit. Then we reevaluate which current subtype system (among CCS, CRCA, CCMS) is the best for identifying patients that will get benefit from oxaliplatin, or we develop a better classification system to define subtypes in terms of oxaliplatin benefit. In addition, we also develop signatures based on other approaches by combining information obtained from gene module analyses.

Study Design II

We have downloaded the original training datasets for CCS, CCMS and CRCA classifier. The original training dataset for CCS and CCMS includes 90 and 566 patients respectively. Note the original CRCA training dataset is the combination of two datasets, to avoid the impact of batch effect, in our analyses; we analyzed the two datasets for CRCA analysis separately.
For each dataset, we performed WGCNA analysis on the genes used for the specific classifier. In addition, although these three classifiers all started with genes having large variance, the list of genes is different (FIG. 2). We also performed WGCNA analysis on the union of genes used for all three classifiers (4510). A Venn diagram of genes used for developing subtype classifiers appear in FIG. 6.
WGCNA constructed a network using adjacency matrix, which is constructed by using the soft-threshold approach (13=8) on the matrix of pair-wise correlation coefficients. Topological overlap distance was then calculated from the adjacency matrix, and used to build a hierarchical clustering tree. Modules were defined as branches of a hierarchical clustering tree, with a minimum module size of 50 genes. A module eigengene distance threshold of 0.4 was also used to merge highly similar modules. Each module is assigned a unique color label. For the convenience of comparison, we matched the module colors from different training dataset based on modules identified in CCMS training dataset. WGCNA analysis was done using WGCNA R package
We assigned each patient to different subtype in CCS, CRCA or CCMS clustering system using SSP method, the centroid was obtained from the original publications. We further identified differentially expressed genes for each subtype using SAM method, and plotted such information underneath the WGCNA tree.

Results

For each dataset, we performed WGCNA analysis on the genes used for the specific classifier (data not shown) and the union of genes used for training three classifiers (4510 genes) in the WGCNA analysis in CCMS training datasets. The module colors are assigned by WGCNA algorithm automatically, based on the ranking of module size.
To understand how these modules are related to subtype, information of genes' expression in each subtype was added in the tree plot. In CCMS training dataset ( ), six large modules were identified, and these gene modules express differently in different subtypes. Turquoise module, the largest module, includes 1424 genes, and most of these over expressed in stem-like/ccs3/CCMS4 and CCMS6. Importantly, the turquoise module contains stromal and epithelial to mesenchymal related genes demonstrating the functional information that can be inferred with modular analysis. The black module includes 866 genes, they overexpressed in stem-like/ccs3/CCMS4, and inflammatory/ccs2/CCMS2. The brown module includes 649 genes, overexpressed in inflammatory/ccs/CCMS2. The yellow module includes 613 genes, overexpressed in TA/ccs1/CCMS1/CCMS5. The green module includes 506 genes, doesn't seem to have a clear pattern. The red module includes 452 genes, overexpressed in goblet/CCM3, enterocyte/CCMS6.

Turquoise	1424				+
Black	866			+	+
Brown	649			+
Yellow	613					+
Green	506
Red	452	+	+

Similar analyses were performed for other datasets. For the convenience of comparison, we have matched the module color from other datasets to module colors in CCMS training dataset. As shown in FIG. 3B-D, although modules identified in other datasets are different from modules identified in CCMS training datasets, there is significant overlap for modules identified from different datasets, and these modules have distinct expression pattern in different subtypes.
To identify genes that are preserved in different datasets in terms of module membership, we further laid out the significant overlap modules identified in different datasets in the same tree, i.e., genes that are from modules that don't have significant overlap are colored gray.
The data (not shown) shows significant overlap among modules from other datasets, especially for turquoise and black modules identified from CCMS dataset. For brown, yellow and red modules identified in CCMS dataset, they are moderately preserved in other datasets, and sometimes they were further split into smaller modules. For example, in ccs datasets, the brown module in CCMS dataset split into both brown and green modules. Gene selection focuses on genes that are preserved in modules with particular focus on hub genes, i.e, genes which have strong correlation with a large number of genes.
We have identified a list of genes that will be used for identification of subtypes and sub-subtypes with differential benefit from oxaliplatin Table 6. Genes will be selected from this table to include in our code set to profile C-07. Further refinement of the code set will be determined by additional criteria such as a gene's correlation between fresh and FFPE isolated RNA, the preservation in other datasets, and functional analysis.

TABLE 5

Genes for identification of subtypes and sub-subtypes

	CCMS	ccs	CRCA1	CRCA2	potential 1

RGL3	black	black	black	gray
GABRB2	black	gray	black	black
ZDHHC11	turquoise	gray	gray	gray
HOTTIP	black	gray	gray	gray
TCTE3	black	gray	black	black
FAM185A	black	gray	black	black
NKAIN2	turquoise	turquoise	turquoise	gray
SV2C	turquoise	gray	turquoise	turquoise
C17orf78	turquoise	turquoise	turquoise	gray
ERVMER34-1	turquoise	turquoise	turquoise	turquoise
ZNF395	turquoise	gray	gray	gray
NTRK2	brown	gray	gray	gray
SH3TC2	turquoise	turquoise	gray	turquoise
SLC7A8	turquoise	gray	gray	turquoise
LURAP1L	turquoise	gray	gray	turquoise
EDAR	turquoise	turquoise	turquoise	turquoise
SLC6A20	black	gray	gray	gray
FLVCR1-AS1	brown	gray	brown	brown
RUSC1-AS1	turquoise	turquoise	gray	gray
LCN15	turquoise	gray	gray	gray
PLEKHS1	black	black	black	gray
CLDN2	brown	brown	brown	brown
CYP4X1	brown	green	brown	brown
TRIB1	turquoise	gray	turquoise	turquoise
LSS	brown	green	brown	gray
ZDHHC5	brown	green	gray	gray
LRRC8E	brown	green	gray	brown
OTUB2	brown	brown	brown	brown
SCARNA2	yellow	gray	gray	gray
CAMTA1	brown	gray	gray	gray
IL1A	black	magenta	gray	black
CCL20	yellow	red	green	red
NFKBIZ	black	black	black	black
ZC3H12A	black	black	black	black
CXCL1	black	black	black	black
CXCL2	black	black	black	black
CXCL3	brown	brown	gray	gray
C11orf71	black	gray	black	black
KRTAP4-1	yellow	yellow	yellow	gray
MACROD1	brown	green	gray	gray
SAMD12	turquoise	gray	gray	turquoise
GABRA2	turquoise	gray	gray	turquoise
IRS2	turquoise	gray	gray	gray
SLC44A5	green	yellow	gray	red
SEC16B	green	gray	yellow	gray
DEPTOR	turquoise	turquoise	gray	turquoise
EPPK1	brown	green	gray	gray
ALDH7A1	brown	green	gray	gray
UTS2	black	gray	black	black
MYCN	brown	gray	brown	brown
CLCN4	black	black	black	gray
RGMB	brown	green	brown	gray
NMNAT3	brown	gray	gray	gray
DCDC2	black	gray	gray	gray
HIPK2	black	gray	black	gray
ANKRD17	green	green	gray	gray
HINT3	turquoise	gray	gray	turquoise
AIG1	turquoise	gray	gray	gray
TPD52L1	brown	gray	gray	gray
ERO1L	black	magenta	black	gray
SPTBN1	black	gray	black	gray
CD9	brown	green	gray	gray
ENC1	black	gray	gray	gray
DNAJC16	brown	green	gray	gray
NNT	green	green	gray	red
LRRC6	brown	gray	gray	gray
NETO2	brown	green	brown	brown
STK31	green	yellow	yellow	gray
EPB41L2	green	green	gray	gray
SULT1C2	brown	gray	gray	gray
ANKRD18A	brown	gray	gray	brown
SAMD5	brown	gray	brown	brown
NRD1	black	gray	black	gray
6-Mar	turquoise	gray	gray	turquoise
PLCB1	green	yellow	yellow	gray
ZNF678	green	yellow	yellow	red
ZNF738	green	gray	gray	gray
ZNF702P	green	gray	gray	gray
DEPDC7	green	gray	gray	yellow
ALPK1	green	yellow	gray	gray
FAM221A	green	gray	gray	red
RBM11	green	yellow	gray	red
FAM213A	green	gray	gray	gray
RHOBTB3	green	yellow	gray	gray
SLC22A15	green	gray	gray	gray
NT5C2	green	yellow	gray	gray
ZNF124	green	gray	yellow	red
KDM4C	green	green	yellow	red
RALGPS1	green	yellow	yellow	red
TJP2	green	yellow	gray	gray
MBOAT2	green	gray	gray	gray
VEGFA	green	green	gray	gray
ZNF320	green	gray	gray	gray
EEF1A1	green	yellow	gray	gray
TOB1	green	yellow	gray	red
PIK3R1	green	yellow	gray	gray
GK	green	gray	gray	gray
MET	green	yellow	gray	gray
ITPR2	green	gray	gray	gray
GRAMD1C	green	gray	gray	red
DDX26B	green	gray	gray	gray
PRRG1	green	gray	gray	gray
TAF9B	green	green	yellow	gray
ZNF711	green	gray	gray	gray
ZNF614	green	yellow	gray	red
TRIM13	green	yellow	gray	red
ZNF652	green	yellow	gray	gray
ARID2	green	yellow	yellow	red
TIPRL	green	green	yellow	gray
FAM92A1	green	gray	yellow	gray
SQLE	green	green	yellow	gray
LACTB2	green	green	gray	gray
NUBPL	green	yellow	yellow	red
PDE7A	green	green	yellow	yellow
FAM84B	green	yellow	yellow	gray
YWHAZ	green	green	gray	yellow
PDP1	green	green	gray	gray
HRSP12	green	green	yellow	gray
C8orf59	green	green	yellow	yellow
OXR1	green	yellow	yellow	gray
ARFGEF1	green	green	yellow	yellow
EIF3H	green	yellow	yellow	yellow
AZIN1	green	gray	yellow	yellow
UTP23	green	green	yellow	yellow
E2F5	green	green	yellow	gray
MED30	green	green	yellow	gray
HCG11	green	yellow	yellow	yellow
TMEM170B	green	gray	yellow	gray
ZNF439	green	gray	gray	gray
PIWIL4	green	yellow	yellow	red
CCDC146	green	gray	gray	gray
TMEM245	green	yellow	yellow	gray
TAPT1-AS1	green	yellow	yellow	gray
ZNF420	green	yellow	yellow	gray
SMARCE1	green	yellow	yellow	gray
PLA2R1	green	yellow	yellow	gray
RBM6	green	yellow	yellow	gray
DDX17	green	green	gray	gray
EFHC1	green	yellow	gray	gray
HERPUD2	green	green	yellow	yellow
KLHL7	green	gray	gray	gray
7-Sep	green	gray	yellow	gray
ENPP5	green	yellow	yellow	red
SESN3	green	gray	gray	gray
HNMT	green	gray	gray	red
ZBTB38	green	yellow	gray	red
CEP68	green	yellow	yellow	gray
RPL15	green	yellow	yellow	red
ZNF605	green	yellow	yellow	red
KCNH8	green	yellow	yellow	gray
GPCPD1	green	yellow	yellow	gray
LPCAT2	green	gray	yellow	yellow
ORMDL1	green	gray	gray	gray
CLHC1	green	gray	gray	gray
ASXL2	green	yellow	gray	yellow
NR1D2	green	yellow	yellow	gray
TULP4	green	yellow	yellow	yellow
PAN3-AS1	green	yellow	yellow	yellow
ZNF141	green	yellow	yellow	yellow
MLLT4-AS1	green	yellow	yellow	yellow
ZNF226	green	gray	gray	red
ZNF302	green	yellow	gray	red
JPX	green	yellow	yellow	yellow
SKIL	green	yellow	yellow	gray
MBNL2	green	yellow	yellow	gray
PCMTD1	green	yellow	gray	gray
TMEM106B	green	yellow	yellow	gray
ATF6	green	yellow	gray	gray
VAMP4	green	gray	gray	gray
ANKRD10	green	yellow	yellow	gray
NFAT5	green	yellow	gray	yellow
TRAF5	green	yellow	yellow	gray
ZKSCAN1	green	yellow	yellow	yellow
RNF170	green	yellow	yellow	yellow
SRSF6	green	green	yellow	yellow
RBM26	green	yellow	yellow	yellow
MIR17HG	green	yellow	yellow	yellow
SLC25A27	green	yellow	yellow	yellow
AHSA2	green	gray	gray	gray
PNISR	green	yellow	gray	gray
SOS1	green	yellow	gray	gray
KIAA0907	green	yellow	yellow	gray
ATRX	green	gray	yellow	gray
MKLN1	green	green	yellow	gray
FNBP4	green	green	gray	gray
LUC7L3	green	yellow	yellow	gray
OGT	green	green	yellow	gray
MBTD1	green	yellow	yellow	yellow
SLC25A36	green	yellow	yellow	yellow
ANKRD10-IT1	green	yellow	yellow	yellow
COMMD6	green	yellow	yellow	gray
DNAJC3-AS1	green	yellow	yellow	yellow
DOCK9	green	yellow	yellow	yellow
NHLRC3	green	yellow	yellow	yellow
UGGT2	green	yellow	yellow	yellow
DLEU2	green	yellow	yellow	yellow
ARHGEF7	green	yellow	yellow	yellow
ZMYM2	green	yellow	yellow	yellow
ARGLU1	green	yellow	gray	yellow
N4BP2L2	green	yellow	yellow	gray
MTRF1	green	yellow	yellow	gray
UFM1	green	green	yellow	yellow
COG3	green	yellow	yellow	yellow
VPS36	green	yellow	yellow	yellow
SUPT20H	green	yellow	yellow	yellow
MED4	green	green	yellow	yellow
TUBGCP3	green	green	yellow	yellow
CDK8	green	green	yellow	yellow
PDS5B	green	yellow	yellow	yellow
RC3H2	green	green	gray	yellow
ZNF44	green	yellow	gray	red
MB21D1	green	gray	gray	gray
ZNF75A	green	gray	yellow	gray
C9orf64	green	green	yellow	red
ZNF160	green	yellow	yellow	yellow
SAMD4B	green	yellow	yellow	gray
FTX	green	yellow	yellow	yellow
TUG1	green	yellow	yellow	gray
GATAD1	green	yellow	yellow	yellow
RAP2A	green	yellow	yellow	yellow
INO80D	green	yellow	yellow	red
PHACTR2	green	yellow	yellow	gray
PRKCI	green	yellow	yellow	yellow
ZNF148	green	yellow	yellow	yellow
TXNDC9	green	yellow	yellow	yellow
LTN1	green	yellow	yellow	red
SLC5A3	green	yellow	yellow	yellow
ZNF397	green	yellow	yellow	gray
ZNF573	green	yellow	yellow	yellow
TMEM19	green	yellow	gray	red
IL7	green	gray	gray	gray
NPNT	green	gray	gray	gray
GDPD1	green	gray	gray	red
RAB2A	green	yellow	gray	gray
INPP4B	green	gray	gray	gray
SCARB2	green	green	gray	gray
KDM6A	green	green	gray	gray
B3GALNT2	green	green	yellow	gray
LRIG3	green	green	gray	gray
SETD9	green	gray	gray	red
LONRF1	green	yellow	yellow	gray
EFCAB2	green	green	gray	gray
NET1	green	green	gray	gray
BTBD3	green	gray	gray	gray
LINC00342	green	gray	gray	gray
CANX	green	green	gray	red
CDC14B	green	yellow	gray	red
SYNJ2BP	green	gray	gray	red
NCOA7	green	gray	gray	gray
FZD3	green	gray	gray	gray
VMP1	green	yellow	gray	gray
ZNF268	green	yellow	gray	red
SCAPER	green	gray	gray	gray
LRIF1	green	yellow	yellow	red
ZHX1	green	yellow	yellow	yellow
GDAP1	green	gray	gray	gray
MBIP	green	green	gray	gray
KIAA0368	green	yellow	gray	gray
NAMPT	green	gray	gray	gray
DNAJC3	green	gray	gray	gray
OTUD3	green	green	gray	gray
PPM1L	green	gray	gray	gray
MLH3	green	gray	gray	gray
RAD52	green	green	gray	red
MSI2	green	green	yellow	gray
B3GNT2	green	green	gray	gray
CRYZ	green	gray	gray	gray
MPZL2	green	green	gray	red
ARMC8	green	gray	gray	gray
STAMBPL1	green	green	gray	gray
RPL31	green	gray	gray	gray
CNOT6L	green	green	gray	gray
BTC	green	gray	gray	gray
ZNF432	green	gray	gray	gray
SLC39A10	green	gray	yellow	gray
ACTR2	green	green	yellow	yellow
PIGN	green	green	gray	gray
CDK6	green	green	gray	gray
FAM179B	green	gray	gray	gray
BCKDHB	green	green	gray	red
PELI1	green	gray	gray	gray
STX6	green	green	gray	gray
ARHGAP18	green	green	yellow	red
PGAP1	green	green	gray	red
ITGA2	green	gray	gray	gray
ITGA6	green	green	gray	gray
SNX25	green	green	gray	gray
ZNF112	green	yellow	gray	gray
EIF5A2	green	gray	gray	gray
HMGN5	green	gray	gray	gray
EIF3F	green	green	gray	gray
DPY19L1	green	green	gray	gray
PTPLB	green	green	gray	red
C1GALT1	green	green	gray	gray
RRM2B	green	green	gray	gray
CEP70	green	gray	gray	gray
ADAM9	green	green	gray	gray
PDK1	green	green	gray	gray
GCH1	green	gray	gray	gray
NUCB2	green	gray	gray	gray
ASPH	green	gray	gray	gray
G3BP2	green	green	gray	red
ETNK1	green	gray	gray	gray
SPTSSA	green	green	gray	gray
ZADH2	green	green	gray	red
KRAS	green	gray	gray	gray
DYRK2	green	yellow	gray	gray
CSNK1A1	green	green	gray	gray
ACBD3	green	gray	gray	gray
MAP3K5	green	gray	gray	gray
SGMS2	green	gray	gray	gray
ANP32E	green	gray	gray	gray
KCTD3	green	green	gray	gray
TAF1A	green	gray	gray	gray
SGMS1	green	gray	gray	gray
KATNBL1	green	gray	gray	gray
CTDSPL2	green	green	gray	gray
DTWD1	green	gray	gray	gray
RFX7	green	green	gray	gray
FEM1B	green	green	gray	gray
HECTD1	green	gray	gray	gray
SGPP1	green	green	gray	gray
FAM102B	green	gray	gray	gray
BLZF1	green	gray	gray	gray
PPP2R5C	green	gray	gray	gray
SPRED1	green	green	gray	gray
UHMK1	green	green	gray	gray
RPRD1A	green	green	gray	gray
MDM2	green	green	gray	gray
PGGT1B	green	green	gray	gray
PRPF39	green	green	gray	gray
RBM25	green	green	gray	gray
PCNXL4	green	gray	gray	gray
EXOC5	green	green	gray	gray
STYX	green	green	gray	gray
ARHGAP5	green	green	gray	gray
STRN3	green	green	gray	gray
IMPACT	green	gray	gray	gray
TMOD3	green	green	gray	gray
GALNT1	green	gray	gray	gray
ANKRD12	green	gray	gray	gray
SOCS6	green	gray	gray	gray
NAPG	green	green	gray	gray
MIB1	green	gray	gray	gray
ESCO1	green	gray	gray	gray
SMCHD1	green	gray	gray	gray
MAGT1	green	green	gray	gray
MORF4L2	green	yellow	yellow	gray
RP2	green	green	gray	gray
NXT2	green	gray	gray	gray
PIGA	green	green	gray	gray
RPS24	green	green	yellow	red
TPR	green	green	gray	gray
LPGAT1	green	green	gray	gray
PTAR1	green	gray	gray	gray
RFX3	green	green	gray	red
MYO6	green	green	gray	gray
AP1S2	green	gray	gray	gray
STK38L	green	yellow	gray	gray
PTPRG	green	green	gray	gray
CAPZA2	green	green	gray	gray
MYO1B	green	green	gray	gray
STARD4	green	gray	gray	gray
B4GALT6	green	gray	gray	gray
GPAM	green	yellow	gray	gray
SEPSECS	green	gray	gray	red
PLA2G12A	green	green	gray	red
CACUL1	green	green	gray	gray
NBN	green	green	gray	gray
ZCCHC7	green	yellow	gray	red
GLS	green	yellow	gray	gray
ATP2C1	green	gray	gray	gray
DDX3X	green	green	gray	gray
SCAMP1	green	green	gray	gray
NAA15	green	green	gray	gray
API5	green	yellow	gray	gray
YME1L1	green	gray	gray	red
NF1	green	green	gray	yellow
EML4	green	green	yellow	red
ADAM1A	green	yellow	yellow	red
SLC38A1	green	yellow	yellow	red
ATP11B	green	green	gray	red
TBL1XR1	green	green	gray	gray
FNIP1	green	green	yellow	red
TTC37	green	yellow	yellow	red
EEA1	green	green	yellow	gray
RAD50	green	yellow	yellow	red
PAWR	green	gray	yellow	yellow
PTBP3	green	green	gray	gray
SLC30A9	green	gray	gray	gray
PSIP1	green	green	gray	gray
SLC4A7	green	green	gray	gray
NIPBL	green	gray	gray	gray
DNAJC10	green	gray	gray	gray
CBR4	green	yellow	gray	red
BOD1L1	green	gray	gray	gray
YTHDC2	green	green	gray	gray
MATR3	green	green	gray	red
PAPD4	green	gray	gray	gray
TRPM7	green	green	gray	red
WDR11	green	yellow	gray	gray
AFF4	green	gray	gray	gray
C5orf24	green	green	gray	gray
ATF2	green	green	gray	gray
ZFYVE16	green	gray	gray	gray
SP3	green	yellow	yellow	yellow
TLK1	green	green	gray	red
SF3B1	green	gray	gray	gray
UBXN4	green	green	gray	gray
USP34	green	yellow	gray	gray
JMJD1C	green	gray	gray	gray
RICTOR	green	green	gray	gray
CLASP2	green	yellow	gray	gray
TMEM33	green	green	gray	red
DCAF17	green	green	gray	yellow
ZNF107	green	gray	yellow	gray
WDR36	green	green	gray	gray
GPR180	green	gray	gray	gray
THAP9-AS1	green	green	gray	gray
PPP6R3	green	green	gray	gray
KIAA1731	green	gray	gray	gray
ARL5B	green	gray	gray	gray
ZFR	green	green	gray	yellow
STRN	green	yellow	gray	red
PDZD8	green	green	gray	gray
CHML	green	gray	gray	gray
ATL2	green	green	yellow	gray
HOOK1	green	gray	gray	red
SERBP1	green	yellow	gray	gray
ANKRD28	green	gray	gray	red
G2E3	green	gray	gray	gray
KIF21A	green	gray	gray	gray
UBA6	green	green	gray	gray
LIN7C	green	green	gray	gray
PDS5A	green	gray	gray	gray
FAR1	green	green	gray	gray
PRPF38B	green	yellow	gray	gray
MYSM1	green	green	gray	red
TRMT13	green	yellow	yellow	red
ZNF644	green	green	gray	gray
LARP4	green	green	gray	gray
CEP152	green	gray	gray	gray
CBX3	green	green	yellow	yellow
CREBZF	green	green	gray	gray
U2SURP	green	yellow	gray	gray
RIF1	green	gray	gray	gray
SMC3	green	gray	gray	gray
TMA16	green	green	gray	gray
SEC23IP	green	green	gray	gray
BBS7	green	gray	gray	gray
PAQR3	green	gray	gray	gray
DAAM1	green	gray	gray	gray
OIP5-AS1	green	gray	gray	gray
EIF4A2	green	yellow	gray	gray
CCSER2	green	gray	gray	gray
NAB1	green	green	gray	gray
WSB1	green	gray	gray	gray
PRKAR1A	green	green	gray	gray
MFAP3	green	green	gray	gray
POLI	green	gray	gray	gray
CCDC91	green	yellow	gray	gray
USP32P2	green	gray	gray	gray
HIPK3	green	green	gray	gray
TMEM30A	green	green	gray	gray
CPEB4	green	green	gray	gray
DMXL2	green	gray	gray	gray
MBNL1	green	green	gray	gray
REEP3	green	green	gray	gray
PDE3B	green	green	gray	gray
EXPH5	green	green	gray	red
ACVR1C	green	gray	gray	red
PPARA	green	yellow	gray	red
NUDT12	green	gray	gray	red
GCNT1	green	gray	gray	red
NSUN7	green	gray	gray	red
MLLT3	green	green	gray	red
APIP	green	yellow	gray	red
SPAG1	green	gray	gray	red
TMEM38B	green	green	yellow	red
MPP7	green	gray	gray	red
IL20RA	green	yellow	yellow	red
SOWAHC	green	yellow	gray	red
TMEM170A	green	green	yellow	yellow
KLF5	green	gray	yellow	red
DDAH1	green	green	gray	red
HNF4G	green	green	gray	red
OCLN	green	green	yellow	gray
GIPC2	green	yellow	gray	red
RNF128	green	yellow	yellow	red
HSDL2	green	gray	yellow	red
GOLIM4	green	green	gray	red
KIF5B	green	green	yellow	yellow
ZBTB18	green	green	yellow	red
SLC12A2	green	gray	gray	red
STXBP6	green	gray	gray	red
IFT74	green	gray	gray	red
CXADR	green	green	gray	red
ADD3	green	yellow	gray	red
CERS6	green	green	gray	red
SH3YL1	green	yellow	yellow	red
NEBL	green	yellow	yellow	red
CD46	green	yellow	yellow	red
TRIM2	green	green	gray	red
PRRG4	green	green	gray	red
LGALSL	green	yellow	gray	red
CYP2J2	green	gray	gray	red
XK	green	gray	gray	red
CMAS	green	gray	gray	red
FAR2	green	gray	gray	red
NHSL1	green	yellow	gray	red
PFKFB2	green	gray	gray	red
FAM110C	green	yellow	gray	red
HSD17B11	green	gray	gray	red
AKAP7	green	gray	gray	red
TMEM56	green	gray	gray	red
KIAA1244	green	gray	gray	red
RASEF	green	gray	gray	red
DENND1B	green	gray	gray	red
FGD4	green	green	gray	red
CYP3A5	green	gray	gray	red
RABGAP1L	green	gray	gray	red
EDEM3	green	gray	gray	red
RASSF6	green	gray	gray	red
HIGD1A	green	gray	gray	gray
PTP4A1	green	green	gray	red
TMEM144	green	green	gray	red
ITGB6	green	gray	gray	red
FAM13A	green	gray	gray	red
ANK3	green	gray	gray	red
SLC40A1	green	gray	gray	red
CDC42SE2	green	gray	gray	red
SLC35F5	green	gray	yellow	red
WASL	green	green	gray	gray
AKAP9	green	yellow	gray	red
NAPEPLD	green	yellow	gray	red
LAMTOR3	green	gray	gray	gray
MIER3	green	green	gray	red
PPP1CB	green	yellow	gray	gray
LNX1	green	gray	gray	red
MTM1	green	green	gray	red
MECOM	green	yellow	gray	red
EHF	green	green	gray	red
SLC35B3	green	gray	gray	red
SYTL2	green	gray	gray	red
MOB3B	green	gray	gray	red
ARL14	green	gray	gray	red
SLC16A9	green	gray	gray	red
SAMD13	green	gray	gray	red
NIPAL1	green	gray	gray	red
SUCLG2	green	green	gray	red
TDP2	green	gray	gray	red
LRRC31	green	gray	gray	red
STX19	green	gray	gray	red
SLC44A1	green	yellow	gray	red
KRCC1	green	gray	gray	red
TRIQK	green	gray	gray	red
TM9SF3	green	yellow	gray	red
DSG2	green	gray	gray	red
C4orf33	green	gray	gray	red
FRYL	green	gray	gray	red
ARFIP1	green	green	gray	red
USP53	green	gray	gray	red
TPD52	green	gray	gray	gray
FAM135A	green	yellow	gray	red
CD164	green	green	gray	red
KLF3	green	green	gray	red
ABCD3	green	gray	gray	red
GALNT3	green	gray	gray	red
CLCN3	green	green	gray	red
CDS1	green	gray	gray	red
GALNT7	green	green	gray	red
SLC35A3	green	gray	gray	red
TUBBP5	brown	green	gray	gray
SIM2	brown	green	gray	brown
MESP1	brown	gray	brown	brown
DHRS2	brown	gray	brown	brown
RBBP9	brown	gray	gray	gray
CDS2	brown	green	gray	gray
TRMT6	brown	green	gray	brown
ANKEF1	brown	green	gray	gray
CSNK2A1	brown	gray	gray	gray
MKKS	brown	green	gray	gray
CRLS1	brown	gray	gray	gray
SNX5	brown	green	gray	gray
CRNKL1	brown	gray	gray	gray
CSRP2BP	brown	gray	gray	gray
KIF16B	brown	gray	gray	gray
MMAA	brown	gray	gray	brown
CXorf57	brown	brown	gray	gray
LINC00467	brown	gray	gray	brown
CCND1	brown	green	gray	brown
GDF15	brown	green	gray	brown
M6PR	brown	green	gray	gray
EPHB3	brown	green	gray	brown
CNTNAP2	brown	gray	brown	brown
LRRC34	brown	gray	gray	gray
STC2	brown	gray	gray	gray
HAS3	brown	gray	brown	brown
AP1S1	brown	green	gray	brown
DMRT2	brown	gray	gray	gray
SLC29A1	brown	green	gray	gray
HMGCS1	brown	green	brown	brown
INSIG1	brown	green	brown	brown
ZNF850	brown	gray	gray	gray
ANKRD22	brown	green	gray	brown
FAM222A	brown	gray	brown	brown
CHDH	brown	gray	gray	gray
KIF1B	brown	gray	gray	gray
SYBU	brown	gray	gray	gray
COX7B	brown	green	gray	gray
LDLR	brown	brown	gray	gray
GOLT1A	brown	gray	brown	brown
CYB5R2	brown	gray	gray	gray
KDM3B	brown	green	gray	gray
HS6ST2	brown	gray	gray	brown
FDFT1	brown	green	brown	brown
FUOM	brown	gray	gray	brown
ERLIN2	brown	gray	gray	gray
FAM83B	brown	green	gray	brown
CDH3	brown	green	brown	brown
CA5BP1	brown	brown	gray	gray
SLC16A1	brown	green	brown	brown
MSX1	brown	gray	brown	brown
PITX2	brown	gray	gray	brown
KIAA1257	brown	gray	gray	brown
AP2B1	brown	gray	brown	brown
DLG3	brown	green	gray	brown
PROCR	brown	gray	gray	gray
RHPN2	brown	gray	gray	gray
AIM1	brown	gray	brown	brown
PREP	brown	green	gray	gray
CRNDE	brown	green	gray	brown
HMGA2	brown	green	gray	brown
PDK3	brown	gray	brown	gray
SOX12	brown	green	brown	brown
ART3	brown	brown	gray	gray
GRAMD2	brown	gray	gray	gray
PROM2	brown	gray	gray	brown
NSF	brown	gray	gray	gray
TNS4	brown	brown	gray	brown
VSNL1	brown	gray	brown	brown
SMYD2	brown	gray	brown	brown
PODXL2	brown	green	brown	brown
C1orf53	brown	green	gray	brown
FAHD1	brown	gray	gray	gray
BAX	brown	green	gray	brown
PHLPP1	brown	green	gray	brown
HOMER1	brown	gray	brown	brown
UGGT1	brown	green	gray	gray
GRHL1	brown	gray	brown	brown
KISS1R	brown	gray	gray	gray
1-Mar	brown	green	gray	brown
SLC27A5	brown	brown	gray	brown
EPHX4	brown	gray	gray	gray
NAP1L1	brown	green	brown	gray
ASB9	brown	brown	gray	gray
SLC35A2	brown	green	gray	brown
HSD17B10	brown	gray	gray	gray
PDHA1	brown	gray	gray	gray
RNFT2	brown	brown	brown	gray
DIS3L2	brown	gray	gray	brown
ACAT1	brown	brown	brown	gray
OR7E14P	brown	brown	gray	brown
ABHD11	brown	green	gray	brown
YWHAE	brown	green	gray	brown
CTH	brown	brown	gray	brown
TAF15	brown	gray	brown	brown
PDCD6	brown	gray	brown	brown
MANEAL	brown	green	brown	brown
SLCO4A1	brown	gray	brown	brown
MSL2	brown	green	gray	brown
NFATC3	brown	gray	brown	brown
BIK	brown	green	gray	brown
MTMR1	brown	green	gray	gray
C2CD4A	brown	brown	gray	brown
ENSA	brown	green	brown	gray
DNAJC14	brown	green	brown	gray
GLS2	brown	green	gray	brown
CBFB	brown	green	gray	gray
TM7SF3	brown	green	gray	brown
PRKX	brown	green	gray	gray
GDI2	brown	green	brown	brown
GSR	brown	green	brown	brown
MFHAS1	brown	green	brown	brown
PPP2R2A	brown	gray	gray	brown
UBXN8	brown	gray	brown	brown
AGPAT5	brown	brown	brown	brown
CNOT7	brown	green	brown	brown
SF1	brown	gray	brown	gray
SUMF2	brown	green	gray	brown
PRCC	brown	green	brown	gray
HYOU1	brown	green	gray	gray
EIF5A	brown	green	gray	brown
SIN3A	brown	green	gray	brown
GLUD1	brown	green	gray	gray
RAB8A	brown	green	gray	gray
YWHAH	brown	green	brown	gray
CDK9	brown	green	gray	brown
DCAKD	brown	green	gray	brown
EXOSC6	brown	green	gray	brown
PDIA4	brown	green	brown	brown
PPIB	brown	green	brown	brown
HNRNPL	brown	green	gray	brown
COPG1	brown	green	gray	brown
STT3A	brown	green	brown	brown
RPN1	brown	green	gray	brown
SNRNP40	brown	green	brown	brown
FAM169A	brown	brown	gray	brown
CCDC47	brown	green	brown	brown
PLEKHG4	brown	gray	gray	gray
BAG5	brown	green	gray	brown
F12	brown	brown	brown	brown
DLGAP1-AS2	brown	gray	gray	gray
MCCC2	brown	green	brown	brown
TGIF1	brown	gray	gray	brown
MLEC	brown	green	brown	gray
THRAP3	brown	gray	brown	brown
ST7L	brown	gray	gray	gray
HES6	brown	gray	brown	brown
SMKR1	brown	green	brown	brown
MEX3D	brown	green	brown	gray
STEAP3	brown	green	brown	gray
AJUBA	brown	gray	brown	brown
GSTO2	brown	brown	brown	brown
LIMD1	brown	green	gray	gray
CDKAL1	brown	green	gray	brown
ATP5S	brown	gray	gray	brown
TCTEX1D2	brown	brown	brown	gray
MPP6	brown	gray	brown	brown
MOB1A	brown	green	brown	brown
RAB6A	brown	green	brown	brown
PDSS2	brown	gray	brown	gray
SAFB	brown	green	gray	gray
SLC1A4	brown	green	brown	gray
TRIB3	brown	gray	gray	brown
CBX2	brown	green	brown	brown
ELOVL7	brown	brown	gray	brown
PSMC2	brown	green	brown	brown
EIF3B	brown	gray	gray	gray
TRRAP	brown	green	brown	gray
MCM3AP-AS1	brown	gray	gray	gray
PMAIP1	brown	gray	gray	brown
C12orf75	brown	green	gray	brown
PITX1	brown	green	brown	brown
RPL35A	brown	gray	brown	gray
FBXO41	brown	green	gray	gray
CRKL	brown	green	brown	brown
AKIRIN1	brown	green	gray	gray
PPP3R1	brown	green	brown	brown
CTNNB1	brown	green	gray	gray
HNRNPH1	brown	green	gray	brown
CCDC117	brown	green	brown	brown
TRA2A	brown	gray	gray	brown
KDM1B	brown	gray	brown	brown
IL17RB	brown	brown	brown	brown
SSR1	brown	green	gray	brown
DHCR24	brown	brown	brown	brown
PKP4	brown	green	gray	gray
SLC7A11	brown	gray	gray	brown
SUMO2	brown	green	gray	brown
RBBP5	brown	green	gray	brown
TLCD1	brown	gray	gray	brown
APOBEC3B	brown	brown	gray	brown
SLC35F2	brown	brown	brown	brown
BTG3	brown	gray	brown	brown
SUDS3	brown	green	gray	gray
NCEH1	brown	green	gray	brown
RAB15	brown	green	gray	gray
TMEM52	brown	green	brown	brown
SLC43A1	brown	green	brown	brown
AIFM2	brown	brown	brown	brown
HDAC8	brown	brown	gray	gray
ZNF239	brown	gray	brown	gray
RAP1GDS1	brown	gray	brown	brown
H2AFY	brown	gray	gray	brown
PGK1	brown	gray	brown	brown
ZNF207	brown	gray	brown	brown
HPDL	brown	gray	brown	brown
DNAH14	brown	gray	gray	brown
RAB3IP	brown	brown	gray	gray
PIR	brown	brown	brown	brown
CISD2	brown	brown	brown	brown
ITCH	brown	green	gray	gray
AP1S3	brown	brown	brown	brown
ARNTL2	brown	gray	gray	brown
CCNO	brown	brown	brown	brown
CDC25B	brown	green	brown	brown
TCF3	brown	green	brown	brown
TRMU	brown	brown	brown	brown
MAT2A	brown	green	gray	brown
THNSL1	brown	brown	brown	brown
RSL1D1	brown	brown	gray	brown
TAF11	brown	green	gray	brown
CD47	brown	gray	gray	brown
FDXR	brown	green	gray	brown
KBTBD8	brown	brown	brown	brown
C14orf2	brown	brown	brown	brown
EMC1	brown	green	gray	brown
PGD	brown	green	brown	brown
GCHFR	brown	brown	brown	brown
CENPV	brown	green	brown	brown
PCSK9	brown	brown	brown	brown
FUS	brown	green	brown	brown
MAP3K9	brown	brown	gray	brown
FAM210A	brown	brown	brown	brown
FAM201A	brown	green	brown	brown
CASP2	brown	green	brown	brown
SHMT1	brown	green	brown	brown
BAG4	brown	brown	gray	gray
ZNF511	brown	brown	brown	brown
SRD5A1	brown	green	brown	brown
LARP1	brown	green	brown	gray
NT5DC2	brown	green	brown	brown
PHKA1	brown	gray	brown	gray
DESI1	brown	green	brown	brown
JPH1	brown	green	brown	brown
CCDC58	brown	brown	brown	brown
STRIP2	brown	brown	brown	brown
VDAC1	brown	green	brown	brown
XPNPEP3	brown	gray	brown	gray
SEC23B	brown	gray	gray	gray
APOOL	brown	gray	gray	brown
DHCR7	brown	green	brown	brown
FAM57A	brown	gray	gray	brown
MRPL2	brown	green	gray	gray
CDV3	brown	green	brown	brown
KCMF1	brown	green	brown	brown
PHGDH	brown	brown	gray	brown
MNS1	brown	brown	brown	brown
PRRT3-AS1	brown	brown	brown	brown
PIGL	brown	green	brown	brown
EBP	brown	gray	brown	brown
IDH2	brown	green	brown	brown
RRP7A	brown	brown	brown	brown
TMED2	brown	green	brown	brown
TFRC	brown	green	brown	brown
SORD	brown	green	brown	brown
AK2	brown	brown	brown	brown
MORC4	brown	brown	brown	brown
MYBBP1A	brown	green	gray	brown
HNRNPA1	brown	green	brown	gray
NANP	brown	gray	gray	gray
FLVCR1	brown	brown	gray	gray
MCM8	brown	gray	gray	brown
PRTFDC1	brown	gray	brown	gray
WEE1	brown	green	brown	gray
LARS2	brown	gray	brown	gray
PRMT6	brown	green	gray	gray
PRPS1	brown	brown	brown	gray
IDH3A	brown	green	brown	brown
PEX13	brown	green	gray	brown
DDT	brown	green	brown	brown
NAP1L4	brown	green	brown	brown
ARG2	brown	brown	brown	brown
RPP25	brown	brown	brown	brown
LSM12	brown	green	brown	brown
GPHN	brown	brown	brown	brown
C5orf22	brown	green	gray	brown
PSMG4	brown	gray	gray	brown
APOO	brown	brown	brown	brown
DCAF16	brown	gray	gray	gray
B9D1	brown	brown	gray	brown
SNRNP48	brown	brown	brown	brown
LYPD6	brown	brown	brown	brown
HN1	brown	green	brown	brown
UBE2I	brown	gray	brown	brown
BOP1	brown	green	brown	brown
SLC3A2	brown	green	gray	brown
FAM216A	brown	brown	brown	brown
ODF2	brown	green	brown	brown
SCAF4	brown	gray	brown	gray
NUP62	brown	green	gray	gray
FH	brown	green	brown	brown
FASN	brown	green	brown	brown
FUT4	brown	brown	brown	brown
SRPRB	brown	green	brown	brown
NDUFS1	brown	green	brown	brown
LIPG	brown	green	brown	brown
MRPS25	brown	gray	brown	brown
EIF4EBP1	brown	brown	brown	brown
MRPL52	brown	green	brown	brown
PRMT5	brown	gray	brown	brown
PSMB5	brown	green	brown	brown
THOC6	brown	green	brown	brown
MIF	brown	green	brown	brown
ENO1	brown	green	brown	brown
LSM2	brown	green	brown	brown
GADD45GIP1	brown	green	brown	brown
MRPS12	brown	green	brown	brown
TIMM50	brown	green	brown	brown
ALYREF	brown	green	brown	brown
TOMM22	brown	green	brown	brown
UBE2M	brown	green	brown	brown
YIF1B	brown	green	brown	brown
ACAT2	brown	brown	brown	brown
QRSL1	brown	gray	gray	brown
ANKRD36	brown	gray	brown	brown
DUT	brown	brown	brown	brown
HBS1L	brown	green	brown	brown
C18orf54	brown	brown	brown	brown
MTHFD2L	brown	brown	brown	brown
AADAT	brown	brown	brown	brown
CDCA7L	brown	brown	brown	brown
PRKDC	brown	green	gray	brown
PPID	brown	gray	gray	brown
XRCC5	brown	gray	gray	brown
EIF4E	brown	green	brown	brown
ASNS	brown	brown	brown	brown
SMS	brown	green	brown	brown
NRF1	brown	gray	brown	brown
BICD1	brown	gray	gray	brown
SFR1	brown	green	gray	brown
MRPL44	brown	green	brown	brown
MTFMT	brown	green	brown	brown
GNPNAT1	brown	brown	brown	brown
DNAAF2	brown	green	brown	brown
TMX1	brown	green	gray	brown
CAND1	brown	gray	gray	brown
RBBP8	brown	brown	gray	brown
RNF138	brown	brown	gray	brown
TIMM21	brown	brown	gray	brown
CHAC2	brown	brown	brown	brown
GEMIN2	brown	brown	brown	brown
CEP76	brown	brown	brown	brown
SEH1L	brown	brown	brown	brown
GLE1	brown	green	brown	brown
SFXN1	brown	brown	brown	brown
SGOL1	brown	gray	brown	brown
FARSB	brown	gray	brown	brown
SET	brown	gray	brown	brown
TRNT1	brown	green	brown	brown
PSPH	brown	green	gray	brown
ACLY	brown	green	brown	gray
ORC5	brown	green	brown	brown
FAM161A	brown	brown	brown	brown
STRAP	brown	gray	brown	brown
AMMECR1	brown	green	gray	brown
RNASEH2B	brown	gray	gray	gray
CENPJ	brown	brown	gray	brown
DIS3	brown	gray	gray	brown
NUDT15	brown	brown	gray	brown
IPO5	brown	green	gray	brown
BRCA2	brown	green	gray	brown
MZT1	brown	brown	gray	brown
EXOSC8	brown	brown	gray	brown
BORA	brown	brown	gray	brown
CKAP2	brown	brown	gray	brown
HNRNPC	brown	gray	brown	brown
SLC7A5	brown	green	gray	brown
PRPS2	brown	gray	gray	gray
LRP8	brown	brown	brown	brown
ZNF165	brown	brown	gray	brown
C1orf174	brown	green	gray	brown
SAP30	brown	brown	brown	gray
CTNNAL1	brown	brown	brown	brown
TKT	brown	green	brown	brown
MRPL50	brown	green	brown	brown
PSMG1	brown	green	brown	brown
TMEM237	brown	gray	brown	gray
NUP50	brown	green	brown	brown
FGFR1OP	brown	green	brown	brown
SPIN4	brown	gray	gray	brown
NSMCE4A	brown	green	brown	brown
NUP210	brown	green	brown	brown
UTP20	brown	green	brown	brown
WDR4	brown	brown	brown	brown
NUP62CL	brown	brown	brown	brown
GAS2L3	brown	brown	brown	brown
SMC1A	brown	brown	gray	brown
SHMT2	brown	green	brown	brown
HSPA4	brown	gray	brown	brown
POLR3G	brown	brown	brown	brown
RRP15	brown	gray	brown	brown
SPATA5L1	brown	brown	brown	brown
HAUS1	brown	brown	brown	brown
GPT2	brown	brown	brown	brown
ADK	brown	green	gray	brown
ELAVL1	brown	green	brown	brown
HSPA9	brown	green	brown	brown
TBC1D30	brown	brown	brown	brown
HNRNPU	brown	gray	gray	brown
PAK6	brown	green	brown	brown
RMI2	brown	brown	brown	brown
TUBA4A	brown	green	brown	brown
KIF9	brown	brown	brown	brown
CHRNA5	brown	brown	brown	brown
MARS2	brow	green	brown	brown
WDR34	brow	brown	brown	brown
PPM1G	brow	green	brown	brown
RBM14	brow	green	brown	brown
HSPD1	brow	gray	brown	brown
EED	brow	gray	brown	brown
SUPT16H	brow	green	brown	brown
TMEM97	brow	green	brown	brown
ILF3	brow	green	brown	gray
GART	brow	gray	brown	brown
CDC23	brow	brown	brown	brown
HMGB3	brow	green	gray	brown
NCBP1	brow	green	brown	brown
PSMA5	brow	gray	brown	brown
ESCO2	brow	brown	brown	brown
WDR76	brow	brown	brown	brown
CCDC150	brow	brown	brown	brown
SAC3D1	brow	brown	brown	brown
METTL21A	brow	gray	brown	brown
C1QBP	brow	green	brown	brown
TSR1	brow	green	brown	brown
MRS2	brow	brown	brown	brown
BRI3BP	brow	brown	brown	brown
RNASEH1	brow	green	brown	brown
SKA2	brow	brown	brown	brown
PHF19	brow	brown	brown	brown
NUP98	brow	green	brown	brown
LSM4	brow	green	brown	brown
PSAT1	brow	brown	brown	brown
TYMS	brow	brown	brown	brown
GSPT1	brow	gray	gray	brown
NUP43	brow	green	gray	brown
TFDP1	brow	brown	gray	brown
G3BP1	brow	green	brown	brown
WDR43	brow	brown	brown	brown
FANCA	brow	brown	brown	brown
GRPEL2	brow	green	brown	brown
IQGAP3	brow	brown	brown	brown
RAD54B	brow	brown	brown	brown
FIGNL1	brow	green	gray	brown
RAD18	brow	brown	brown	brown
PRIM2	brow	green	brown	brown
RCC1	brow	brown	brown	brown
TFAM	brow	green	gray	brown
BCCIP	brow	brown	brown	brown
USP1	brow	brown	brown	brown
GINS1	brow	brown	gray	brown
PPAT	brow	brown	brown	brow
YEATS4	brow	green	brown	brow
SRSF1	brow	green	brown	brow
CACYBP	brow	brown	brown	brow
SNRPD1	brow	brown	brown	brow
TMPO	brow	green	brown	brow
CDK2	brow	green	brown	brow
NUDT5	brow	green	brown	brow
H2AFX	brow	brown	brown	brow
MCM5	brow	brown	brown	brow
LMNB2	brow	green	brown	brow
MCM7	brow	brown	brown	brow
CENPI	brow	brown	gray	brow
DHX9	brow	gray	brown	brow
TMEM194A	brow	green	brown	brow
CENPH	brow	green	brown	brow
SKA3	brow	brown	gray	brow
DIAPH3	brow	brown	gray	brow
RFC3	brow	brown	gray	brow
RANBP1	brow	green	brown	brow
GMNN	brow	brown	brown	brow	brow
CEP78	brow	brown	brown	brow	brow
C1orf112	brow	brown	brown	brow	brow
DHFR	brow	brown	brown	brow	brow
SFPQ	brow	green	brown	brow	brow
WHSC1	brow	green	brown	brow	brow
C4orf46	brow	green	brown	brow	brow
ATAD2	brow	brown	brown	brow	brow
CCNE2	brow	brown	brown	brow	brow
CDCA2	brow	brown	brown	brow	brow
CPSF6	brow	green	brown	brow	brow
ZWILCH	brow	brown	brown	brow	brow
KIAA1524	brow	brown	brown	brow	brow
MASTL	brow	brown	brown	brow	brow
SMC2	brow	brown	brown	brow	brow
KIF14	brow	brown	brown	brow	brow
CENPK	brow	brown	brown	brow	brow
CENPE	brow	brown	brown	brow	brow
SGOL2	brow	brown	brown	brow	brow
PSRC1	brow	brown	brown	brow	brow
BUB3	brow	green	brown	brow	brow
ARHGAP11	brow	brown	brown	brow	brow
CENPW	brow	brown	brown	brow	brow
NASP	brow	brown	brown	brow	brow
CDC7	brow	brown	brown	brow	brow
LMNB1	brow	green	brown	brow	brow
SKA1	brow	brown	brown	brow	brow
TIPIN	brow	brow	brow	brow	brow
PBK	brow	brow	brow	brow	brow
ERCC6L	brow	brow	brow	brow	brow
NEIL3	brow	brow	brow	brow	brow
WDHD1	brow	brow	brow	brow	brow
MCM4	brow	gree	brow	brow	brow
MIS18A	brow	brow	brow	brow	brow
MCM3	brow	gree	brow	brow	brow
AUNIP	brow	brow	brow	brow	brow
UHRF1	brow	gree	brow	brow	brow
CDC25A	brow	gree	brow	brow	brow
CENPM	brow	brow	brow	brow	brow
CDC6	brow	gree	brow	brow	brow
CDT1	brow	gree	brow	brow	brow
TACC3	brow	brow	brow	brow	brow
GINS2	brow	brow	brow	brow	brow
TK1	brow	brow	brow	brow	brow
E2F7	brow	brow	brow	brow	brow
RAD51	brow	brow	brow	brow	brow
FOXM1	brow	brow	brow	brow	brow
KIF18B	brow	brow	brow	brow	brow
PLK1	brow	brow	brow	brow	brow
ORC1	brow	brow	brow	brow	brow
CDCA8	brow	brow	brow	brow	brow
RRM2	brow	brow	brow	brow	brow
KIF20A	brow	brow	brow	brow	brow
OIP5	brow	brow	brow	brow	brow
PRC1	brow	brow	brow	brow	brow
AURKB	brow	brow	brow	brow	brow
CCNB1	brow	brow	brow	brow	brow
CDC20	brow	brow	brow	brow	brow
KIF4A	brow	brow	brow	brow	brow
CDC45	brow	brow	brow	brow	brow
FEN1	brow	brow	brow	brow	brow
MTFR2	brow	brow	brow	brow	brow
BIRC5	brow	gree	brow	brow	brow
CDCA5	brow	brow	brow	brow	brow
KIF2C	brow	brow	brow	brow	brow
MCM10	brow	brow	brow	brow	brow
NCAPH	brow	brow	brow	brow	brow
SKP2	brow	gree	brow	brow	brow
CKS2	brow	brow	brow	brow	brow
HELLS	brow	brow	brow	brow	brow
BRIP1	brow	brow	brow	brow	brow
POLQ	brow	brow	brow	brow	brow
E2F8	brow	brow	brow	brow	brow
PARPBP	brow	brow	brow	brow	brow
NDC80	brow	brown	brow	brow	brow
ECT2	brow	gray	brow	brow	brow
KNSTRN	brow	brown	brow	brow	brow
MKI67	brow	brown	brow	brow	brow
TOP2A	brow	brown	brow	brow	brow
DBF4	brow	brown	brow	brow	brow
EZH2	brow	brown	brow	brow	brow
CASC5	brow	brown	brow	brow	brow
VRK1	brow	brown	brow	brow	brow
DNA2	brow	brown	brow	brow	brow
HMMR	brow	brown	brow	brow	brow
HMGB2	brow	brown	brow	brow	brow
FBXO5	brow	brown	brow	brow	brow
KIF18A	brow	brown	brow	brow	brow
ASPM	brow	brown	brow	brow	brow
CDK1	brow	brown	brow	brow	brow
NUF2	brow	brown	brow	brow	brow
KIF15	brow	brown	brow	brow	brow
CENPN	brow	brown	brow	brow	brow
KIAA0101	brow	brown	brow	brow	brow
CHEK1	brow	brown	brow	brow	brow
UBE2T	brow	brown	brow	brow	brow
NCAPG2	brow	brown	brow	brow	brow
RAD51AP1	brow	brown	brow	brow	brow
ZNF367	brow	brown	brow	brow	brow
CDKN3	brow	brown	brow	brow	brow
POLE2	brow	brown	brow	brow	brow
DTL	brow	brown	brow	brow	brow
STIL	brow	brown	brow	brow	brow
ANLN	brow	brown	brow	brow	brow
MND1	brow	brown	brow	brow	brow
PLK4	brow	brown	brow	brow	brow
DEPDC1	brow	brown	brow	brow	brow
TTK	brow	brown	brow	brow	brow
SPC25	brow	brown	brow	brow	brow
MAD2L1	brow	brown	brow	brow	brow
NCAPG	brow	brown	brow	brow	brow
DEPDC1B	brow	brown	brow	brow	brow
DLGAP5	brow	brown	brow	brow	brow
KIF11	brow	brown	brow	brow	brow
NEK2	brow	brown	brow	brow	brow
EXO1	brow	brown	brow	brow	brow
CEP55	brow	brown	brow	brow	brow
NUSAP1	brow	brown	brow	brow	brow
CCNA2	brow	brown	brow	brow	brow
KIF23	brow	brown	brow	brow	brow
CCNB2	brow	brown	brow	brow	brow
ZWINT	brown	brown	brown	brown	brown
BUB1	brown	brown	brown	brown	brown
BUB1B	brown	brown	brown	brown	brown
LMO7	yellow	yellow	yellow	gray	yellow
EFNA3	yellow	yellow	yellow	red	yellow
TMEM187	yellow	yellow	yellow	gray	yellow
LINC00526	yellow	yellow	green	red	yellow
LINC00667	yellow	yellow	green	red	yellow
CAPN3	yellow	yellow	yellow	red	yellow
MACROD2	yellow	yellow	yellow	gray	yellow
MFAP3L	yellow	gray	gray	gray	yellow
UNC93A	yellow	yellow	gray	gray	yellow
EYA1	yellow	yellow	yellow	gray	yellow
GRIP1	yellow	gray	yellow	gray	yellow
ARSD	yellow	yellow	green	red	yellow
KIAA1211L	yellow	red	yellow	red	yellow
THNSL2	yellow	yellow	yellow	red	yellow
UCA1	yellow	yellow	yellow	yellow	yellow
SCML4	yellow	yellow	gray	red	yellow
CCND2	yellow	gray	green	red	yellow
ESRRG	yellow	yellow	yellow	gray	yellow
ATF7IP2	yellow	gray	yellow	gray	yellow
ZNF608	yellow	gray	yellow	yellow	yellow
FGFRL1	yellow	yellow	yellow	yellow	yellow
SLC38A4	yellow	yellow	yellow	red	yellow
SLC52A3	yellow	red	green	red	yellow
MAVS	yellow	yellow	green	red	yellow
RRBP1	yellow	gray	yellow	red	yellow
PALD1	yellow	gray	yellow	yellow	yellow
SMG7	yellow	gray	yellow	yellow	yellow
CAPN10	yellow	yellow	yellow	gray	yellow
ZNF682	yellow	yellow	yellow	gray	yellow
SMAD6	yellow	red	yellow	red	yellow
NYNRIN	yellow	yellow	green	red	yellow
SULT2B1	yellow	yellow	yellow	red	yellow
CAMKK2	yellow	yellow	yellow	gray	yellow
RAB11FIP1	yellow	gray	gray	red	yellow
TMEM139	yellow	red	green	red	yellow
BMP7	yellow	gray	yellow	gray	yellow
GPR115	yellow	yellow	yellow	gray	yellow
PLBD1	yellow	red	green	red	yellow
CYP4F11	yellow	yellow	green	red	yellow
SYK	yellow	yellow	yellow	red	yellow
PERP	yellow	gray	yellow	yellow	yellow
CAPN13	yellow	yellow	green	red	yellow
L3MBTL4	yellow	yellow	gray	gray	yellow
ELF5	yellow	yellow	yellow	gray	yellow
IGF2R	yellow	gray	yellow	gray	yellow
KANSL1	yellow	yellow	yellow	gray	yellow
PRSS33	yellow	yellow	yellow	yellow	yellow
ADRBK2	yellow	gray	yellow	gray	yellow
CLYBL	yellow	yellow	green	red	yellow
CRYL1	yellow	red	yellow	red	yellow
GLYR1	yellow	yellow	yellow	gray	yellow
COL9A1	yellow	yellow	yellow	gray	yellow
ZNF503-AS1	yellow	red	green	red	yellow
CHRM3	yellow	gray	gray	gray	yellow
IGF2BP2	yellow	yellow	yellow	yellow	yellow
BEX2	yellow	yellow	green	gray	yellow
SCD	yellow	gray	yellow	gray	yellow
PYGB	yellow	yellow	gray	red	yellow
SPATC1L	yellow	yellow	gray	gray	yellow
MROH1	yellow	gray	gray	yellow	yellow
SLC39A4	yellow	yellow	yellow	gray	yellow
SLC52A2	yellow	gray	yellow	gray	yellow
KRT40	yellow	yellow	yellow	gray	yellow
CYP39A1	yellow	yellow	green	red	yellow
CADPS	yellow	yellow	green	red	yellow
PCLO	yellow	yellow	yellow	red	yellow
KAZN	yellow	yellow	green	yellow	yellow
C6orf223	yellow	yellow	yellow	gray	yellow
PLAG1	yellow	yellow	gray	gray	yellow
ZNF813	yellow	gray	gray	yellow	yellow
TP53TG1	yellow	yellow	yellow	red	yellow
QPCT	yellow	yellow	yellow	red	yellow
ZNF827	yellow	yellow	yellow	red	yellow
EIF3C	yellow	yellow	yellow	red	yellow
SLC35E4	yellow	yellow	yellow	red	yellow
FAM3B	yellow	yellow	yellow	red	yellow
FOXA2	yellow	gray	yellow	red	yellow
CAMK1D	yellow	yellow	green	red	yellow
CYFIP2	yellow	yellow	yellow	red	yellow
MYEF2	yellow	yellow	yellow	gray	yellow
ARL11	yellow	yellow	gray	gray	yellow
RNF182	yellow	yellow	yellow	yellow	yellow
EFNA1	yellow	gray	green	red	yellow
PLEKHB1	yellow	yellow	yellow	gray	yellow
ZFP36L2	yellow	gray	gray	yellow	yellow
SOX9	yellow	gray	yellow	red	yellow
HKDC1	yellow	red	yellow	gray	yellow
RASSF10	yellow	yellow	yellow	red	yellow
RAB11FIP3	yellow	yellow	yellow	gray	yellow
ME3	yellow	yellow	yellow	red	yellow
TNMD	yellow	yellow	yellow	gray	yellow
PVR	yellow	gray	yellow	red	yellow
ACOX2	yellow	yellow	green	red	yellow
ZNF506	yellow	yellow	gray	gray	yellow
SHISA9	yellow	yellow	yellow	gray	yellow
MCF2L	yellow	yellow	yellow	yellow	yellow
RNLS	yellow	yellow	green	red	yellow
CCDC170	yellow	yellow	yellow	red	yellow
OXGR1	yellow	yellow	green	gray	yellow
VANGL2	yellow	yellow	yellow	yellow	yellow
FOXQ1	yellow	gray	yellow	yellow	yellow
SLC17A9	yellow	yellow	yellow	yellow	yellow
CGREF1	yellow	yellow	yellow	yellow	yellow
ABCC1	yellow	gray	yellow	yellow	yellow
ABCC4	yellow	gray	yellow	yellow	yellow
ZNF529	yellow	yellow	yellow	gray	yellow
ZNF606	yellow	yellow	green	red	yellow
ZNF502	yellow	yellow	green	gray	yellow
SLC11A2	yellow	red	yellow	red	yellow
SLC13A2	yellow	yellow	green	red	yellow
SH3BP4	yellow	yellow	yellow	red	yellow
MGAT5	yellow	yellow	yellow	red	yellow
MYO10	yellow	yellow	yellow	red	yellow
MPC2	yellow	gray	green	red	yellow
PCTP	yellow	yellow	yellow	red	yellow
HDHD1	yellow	yellow	yellow	red	yellow
PNPLA4	yellow	yellow	gray	red	yellow
FCGRT	yellow	yellow	yellow	gray	yellow
TMEM176A	yellow	gray	yellow	gray	yellow
TMEM176B	yellow	gray	yellow	gray	yellow
ABCB1	yellow	yellow	green	red	yellow
JUN	yellow	yellow	yellow	gray	yellow
FGFR3	yellow	yellow	green	red	yellow
SDR42E1	yellow	yellow	green	red	yellow
ALDH4A1	yellow	yellow	yellow	gray	yellow
AZGP1	yellow	yellow	yellow	yellow	yellow
RPS15A	yellow	yellow	yellow	gray	yellow
DENND1A	yellow	gray	gray	red	yellow
SLC22A3	yellow	yellow	yellow	yellow	yellow
CHPT1	yellow	yellow	yellow	red	yellow
C7orf31	yellow	gray	yellow	red	yellow
C11orf1	yellow	gray	yellow	red	yellow
CAMK2N1	yellow	yellow	yellow	yellow	yellow
GPC4	yellow	gray	yellow	red	yellow
CXXC4	yellow	yellow	yellow	gray	yellow
RAB40B	yellow	yellow	gray	red	yellow
GSPT2	yellow	yellow	green	red	yellow
ELAVL2	yellow	yellow	yellow	red	yellow
PLAGL1	yellow	yellow	green	red	yellow
SLC35D3	yellow	yellow	yellow	gray	yellow
IP6K2	yellow	yellow	yellow	red	yellow
ZNF814	yellow	yellow	yellow	red	yellow
UNC5CL	yellow	yellow	yellow	yellow	yellow
EVPL	yellow	yellow	yellow	red	yellow
SLC1A7	yellow	yellow	yellow	red	yellow
ANKH	yellow	gray	yellow	red	yellow
KANK1	yellow	yellow	yellow	red	yellow
NEURL1B	yellow	yellow	green	gray	yellow
SHH	yellow	yellow	green	red	yellow
PAQR5	yellow	yellow	green	red	yellow
AMT	yellow	yellow	green	gray	yellow
EFNA2	yellow	red	green	red	yellow
MYO15B	yellow	yellow	green	red	yellow
TMC5	yellow	red	green	red	yellow
CGN	yellow	red	green	red	yellow
PTK6	yellow	red	yellow	yellow	yellow
CC2D1A	yellow	gray	green	red	yellow
MYH14	yellow	red	green	red	yellow
CYP2S1	yellow	yellow	green	red	yellow
MGAT4B	yellow	gray	green	red	yellow
LRP4	yellow	yellow	green	red	yellow
KLC4	yellow	yellow	yellow	red	yellow
ARHGAP44	yellow	red	gray	red	yellow
PCK1	yellow	red	green	red	yellow
SEMA6D	yellow	red	green	red	yellow
SEMA6A	yellow	red	green	red	yellow
SLC26A2	yellow	red	green	red	yellow
TRPM6	yellow	yellow	green	red	yellow
SORT1	yellow	gray	green	red	yellow
ID1	yellow	red	green	red	yellow
GPR39	yellow	red	yellow	red	yellow
LEFTY1	yellow	red	green	red	yellow
CKB	yellow	red	green	red	yellow
PAQR8	yellow	red	green	red	yellow
KIAA1161	yellow	red	green	red	yellow
OLFM4	yellow	red	green	red	yellow
ZSWIM5	yellow	red	green	red	yellow
TOX3	yellow	gray	green	red	yellow
WNK2	yellow	yellow	green	red	yellow
B3GNT3	yellow	red	green	red	yellow
ARHGEF5	yellow	yellow	yellow	red	yellow
CLDN4	yellow	red	yellow	red	yellow
PHYH	yellow	yellow	green	red	yellow
PIWIL2	yellow	red	green	red	yellow
ABCC6	yellow	yellow	yellow	red	yellow
CCRL2	yellow	red	green	red	yellow
ACSF2	yellow	yellow	green	red	yellow
TGOLN2	yellow	yellow	yellow	yellow	yellow
HTATIP2	yellow	gray	yellow	red	yellow
H2AFJ	yellow	yellow	yellow	red	yellow
CEACAM1	yellow	red	green	red	yellow
SORL1	yellow	yellow	green	red	yellow
RALGAPA2	yellow	yellow	green	red	yellow
KCNQ1	yellow	yellow	yellow	red	yellow
PRR5L	yellow	red	green	red	yellow
ARSE	yellow	yellow	green	red	yellow
WNK4	yellow	red	green	red	yellow
FAM171A1	yellow	yellow	green	red	yellow
CEACAM6	yellow	red	green	red	yellow
GALNT6	yellow	yellow	yellow	red	yellow
ENPP3	yellow	yellow	green	red	yellow
PTPRD	yellow	yellow	green	red	yellow
GRM8	yellow	yellow	green	red	yellow
PTPRK	yellow	yellow	yellow	red	yellow
ZNF704	yellow	yellow	green	red	yellow
LY75	yellow	yellow	yellow	red	yellow
SEMA3C	yellow	yellow	green	gray	yellow
STK38	yellow	yellow	yellow	red	yellow
IYD	yellow	yellow	green	red	yellow
NUDT4	yellow	yellow	yellow	red	yellow
AUTS2	yellow	yellow	green	red	yellow
DIAPH2	yellow	yellow	green	yellow	yellow
PRLR	yellow	yellow	yellow	red	yellow
SEMA5A	yellow	yellow	green	red	yellow
CTTNBP2	yellow	yellow	green	red	yellow
PLCB4	yellow	red	yellow	red	yellow
REPS2	yellow	red	green	red	yellow
FAM105A	yellow	red	green	red	yellow
SATB2-AS1	yellow	yellow	green	red	yellow
PRKAB1	yellow	red	green	red	yellow
HMGCS2	yellow	red	green	red	yellow
CXCL14	yellow	yellow	green	red	yellow
TSPAN12	yellow	yellow	green	red	yellow
HEPH	yellow	red	green	red	yellow
POF1B	yellow	red	green	red	yellow
LINC00483	yellow	red	green	red	yellow
MOGAT3	yellow	yellow	green	red	yellow
GJB1	yellow	yellow	green	red	yellow
ETS2	yellow	gray	green	red	yellow
CASP6	yellow	red	green	red	yellow
GLCE	yellow	yellow	green	red	yellow
PANK1	yellow	red	green	red	yellow
GPX2	yellow	yellow	yellow	red	yellow
ERBB3	yellow	red	yellow	red	yellow
ST14	yellow	red	green	red	yellow
PPARG	yellow	red	green	red	yellow
ILDR1	yellow	red	green	red	yellow
SPINK1	yellow	red	green	red	yellow
SGK2	yellow	yellow	green	red	yellow
ACOX1	yellow	yellow	green	red	yellow
MYO1D	yellow	gray	green	red	yellow
KALRN	yellow	red	green	red	yellow
MUC12	yellow	yellow	green	red	yellow
KRT20	yellow	red	green	red	yellow
PIGZ	yellow	red	green	red	yellow
NAT2	yellow	red	green	red	yellow
FAM134B	yellow	red	green	red	yellow
PBLD	yellow	red	green	red	yellow
SELENBP1	yellow	red	green	red	yellow
PLEKHG6	yellow	yellow	green	red	yellow
TINAG	yellow	yellow	green	red	yellow
SOWAHA	yellow	yellow	green	red	yellow
CEBPA	yellow	yellow	green	red	yellow
TFCP2L1	yellow	yellow	green	red	yellow
ELF3	yellow	red	green	red	yellow
EPS8L3	yellow	red	green	red	yellow
CDH17	yellow	red	green	red	yellow
CEACAM5	yellow	red	green	red	yellow
PRSS8	yellow	red	green	red	yellow
TMPRSS2	yellow	red	green	red	yellow
A1CF	yellow	yellow	green	red	yellow
MUC20	yellow	yellow	green	red	yellow
NOX1	yellow	red	green	red	yellow
TRABD2A	yellow	yellow	green	red	yellow
CDH1	yellow	gray	green	red	yellow
CLDN3	yellow	red	green	red	yellow
DAPK2	yellow	yellow	green	red	yellow
SHROOM1	yellow	yellow	green	red	yellow
MEP1A	yellow	red	green	red	yellow
OVOL1	yellow	yellow	green	red	yellow
ISX	yellow	yellow	green	red	yellow
ACE2	yellow	yellow	yellow	red	yellow
SLC39A5	yellow	yellow	green	red	yellow
SLC3A1	yellow	yellow	green	red	yellow
CDHR1	yellow	yellow	green	red	yellow
PPP1R14C	yellow	yellow	green	red	yellow
SATB2	yellow	yellow	green	red	yellow
ACSL5	yellow	yellow	green	red	yellow
VIL1	yellow	yellow	green	red	yellow
DDC	yellow	yellow	green	red	yellow
CFTR	yellow	yellow	green	red	yellow
AIFM3	yellow	yellow	green	red	yellow
SLC26A3	yellow	red	green	red	yellow
EPB41L4B	yellow	yellow	green	red	yellow
LRRC19	yellow	red	green	red	yellow
FABP1	yellow	red	green	red	yellow
C10orf99	yellow	red	green	red	yellow
PPP1R14D	yellow	yellow	green	red	yellow
NR1I2	yellow	yellow	green	red	yellow
PRR15	yellow	yellow	green	red	yellow
CDX2	yellow	yellow	green	red	yellow
IHH	yellow	yellow	green	red	yellow
FAM84A	yellow	red	green	red	yellow
ATP10B	yellow	yellow	green	red	yellow
GPR160	yellow	yellow	green	red	yellow
GUCY2C	yellow	yellow	green	red	yellow
SCARB1	yellow	yellow	yellow	red	yellow
ZBED3	yellow	gray	yellow	gray	yellow
TMEM63A	yellow	gray	yellow	yellow	yellow
ATAT1	yellow	yellow	yellow	yellow	yellow
PTP4A3	yellow	yellow	yellow	yellow	yellow
ABHD12	yellow	yellow	yellow	yellow	yellow
HNF4A	yellow	yellow	yellow	gray	yellow
ATP7B	yellow	yellow	yellow	red	yellow
GRTP1	yellow	red	yellow	gray	yellow
STK24	yellow	gray	yellow	yellow	yellow
CELSR3	yellow	yellow	yellow	yellow	yellow
TBC1D5	yellow	yellow	yellow	gray	yellow
KLHDC10	yellow	gray	yellow	yellow	yellow
C20orf196	yellow	yellow	green	red	yellow
LINC00525	yellow	yellow	yellow	yellow	yellow
DNAJC15	yellow	yellow	yellow	yellow	yellow
FAM210B	yellow	yellow	yellow	yellow	yellow
RPS6KA6	yellow	yellow	yellow	red	yellow
CCDC113	yellow	yellow	yellow	red	yellow
GYLTL1B	yellow	yellow	yellow	gray	yellow
PROSER2	yellow	yellow	yellow	red	yellow
SNTB1	yellow	gray	yellow	yellow	yellow
SLC2A4RG	yellow	yellow	yellow	yellow	yellow
NOTCH1	yellow	yellow	yellow	red	yellow
SOX4	yellow	yellow	yellow	yellow	yellow
CSNK1E	yellow	gray	yellow	gray	yellow
ZNF503	yellow	gray	yellow	gray	yellow
SLC6A6	yellow	gray	yellow	gray	yellow
FARP1	yellow	yellow	yellow	gray	yellow
PMEPA1	yellow	yellow	yellow	gray	yellow
LGR5	yellow	gray	yellow	red	yellow
STX3	yellow	gray	green	red	yellow
WIF1	yellow	yellow	yellow	yellow	yellow
HIBADH	yellow	gray	yellow	yellow	yellow
MED1	yellow	gray	yellow	yellow	yellow
CLDN1	yellow	yellow	yellow	yellow	yellow
ZNF280B	yellow	yellow	yellow	red	yellow
AOAH	yellow	yellow	yellow	gray	yellow
RNF157	yellow	yellow	yellow	red	yellow
CKMT2	yellow	yellow	yellow	red	yellow
NKD2	yellow	yellow	yellow	gray	yellow
ATP6V1C2	yellow	yellow	yellow	red	yellow
HILPDA	yellow	gray	yellow	gray	yellow
SLC2A12	yellow	yellow	yellow	yellow	yellow
ZNF93	yellow	yellow	gray	gray	yellow
FABP6	yellow	yellow	yellow	red	yellow
PNLIPRP2	yellow	yellow	green	red	yellow
ZNF681	yellow	yellow	gray	red	yellow
PPDPF	yellow	yellow	yellow	yellow	yellow
CYB5B	yellow	yellow	yellow	yellow	yellow
CBX5	yellow	yellow	yellow	red	yellow
REEP1	yellow	yellow	yellow	gray	yellow
ZBTB10	yellow	yellow	green	yellow	yellow
TG	yellow	yellow	yellow	red	yellow
ADCY3	yellow	yellow	gray	yellow	yellow
DIO3OS	yellow	yellow	green	yellow	yellow
LRRC36	yellow	yellow	yellow	gray	yellow
AGT	yellow	yellow	green	gray	yellow
CYP4F2	yellow	yellow	yellow	yellow	yellow
CYP4F3	yellow	yellow	yellow	yellow	yellow
HENMT1	yellow	yellow	yellow	red	yellow
NUDT7	yellow	yellow	green	red	yellow
ZC3H12B	yellow	yellow	yellow	yellow	yellow
FREM2	yellow	yellow	yellow	yellow	yellow
DNAJC6	yellow	yellow	yellow	yellow	yellow
ESPN	yellow	yellow	green	yellow	yellow
IFNLR1	yellow	yellow	yellow	red	yellow
ANXA9	yellow	yellow	yellow	yellow	yellow
ENTPD6	yellow	yellow	yellow	red	yellow
L3MBTL1	yellow	yellow	yellow	gray	yellow
ZNF785	yellow	yellow	yellow	yellow	yellow
SPIN3	yellow	yellow	yellow	yellow	yellow
MCF2L-AS1	yellow	yellow	yellow	red	yellow
TDRKH	yellow	yellow	yellow	yellow	yellow
COBLL1	yellow	yellow	yellow	yellow	yellow
KCNK5	yellow	yellow	green	red	yellow
PHACTR3	yellow	yellow	yellow	yellow	yellow
ST6GAL1	yellow	gray	yellow	red	yellow
MYRIP	yellow	yellow	green	red	yellow
BEND7	yellow	yellow	yellow	red	yellow
DBI	yellow	gray	yellow	red	yellow
FGFR4	yellow	yellow	yellow	red	yellow
AGMAT	yellow	yellow	yellow	red	yellow
RAB11FIP4	yellow	gray	yellow	red	yellow
GNL3L	yellow	yellow	yellow	yellow	yellow
FHDC1	yellow	yellow	green	red	yellow
PPM1H	yellow	yellow	yellow	red	yellow
EPHB2	yellow	yellow	green	red	yellow
ZNF703	yellow	yellow	yellow	red	yellow
NCR3LG1	yellow	yellow	yellow	yellow	yellow
MIPEP	yellow	yellow	yellow	gray	yellow
SLC7A1	yellow	gray	yellow	gray	yellow
PDP2	yellow	yellow	yellow	red	yellow
TFDP2	yellow	yellow	yellow	yellow	yellow
TUFT1	yellow	yellow	yellow	red	yellow
FERMT1	yellow	yellow	yellow	red	yellow
ATP11A	yellow	gray	yellow	yellow	yellow
GTF3A	yellow	yellow	yellow	yellow	yellow
NUFIP1	yellow	yellow	yellow	yellow	yellow
RFXAP	yellow	yellow	yellow	yellow	yellow
DDX18	yellow	gray	yellow	gray	yellow
FSD1L	yellow	yellow	yellow	red	yellow
PIN4	yellow	yellow	yellow	gray	yellow
PUS10	yellow	yellow	yellow	yellow	yellow
PHOSPHO2	yellow	yellow	yellow	red	yellow
TMEM192	yellow	yellow	yellow	red	yellow
MACC1	yellow	yellow	yellow	yellow	yellow
ARMCX5	yellow	yellow	yellow	yellow	yellow
OFD1	yellow	yellow	yellow	yellow	yellow
USP9X	yellow	yellow	yellow	yellow	yellow
CLCN5	yellow	yellow	yellow	yellow	yellow
EIF2S3	yellow	gray	yellow	red	yellow
TAB3	yellow	yellow	yellow	yellow	yellow
EIF1AX	yellow	gray	yellow	yellow	yellow
MED14	yellow	yellow	yellow	red	yellow
POLA1	yellow	gray	yellow	yellow	yellow
TXLNG	yellow	yellow	yellow	yellow	yellow
SCML1	yellow	yellow	yellow	yellow	yellow
FAM122B	yellow	yellow	yellow	yellow	yellow
BRCC3	yellow	yellow	yellow	red	yellow
THOC2	yellow	gray	yellow	yellow	yellow
MEST	yellow	yellow	yellow	yellow	yellow
DUS4L	yellow	yellow	yellow	yellow	yellow
NAA38	yellow	gray	gray	gray	yellow
FAM60A	yellow	gray	yellow	red	yellow
EPB41L5	yellow	yellow	yellow	red	yellow
ZDHHC23	yellow	yellow	green	red	yellow
GPSM2	yellow	yellow	yellow	red	yellow
CDCA7	yellow	yellow	yellow	red	yellow
NFE2L3	yellow	yellow	yellow	red	yellow
SRPK1	yellow	gray	yellow	red	yellow
MYB	yellow	red	green	red	yellow
STRBP	yellow	yellow	yellow	red	yellow
CLDN15	yellow	yellow	yellow	yellow	yellow
ERP27	yellow	yellow	yellow	red	yellow
APCDD1	yellow	yellow	yellow	yellow	yellow
CAB39L	yellow	yellow	yellow	gray	yellow
SYNE4	yellow	yellow	gray	yellow	yellow
IRF2BP2	yellow	gray	yellow	yellow	yellow
PTPRO	yellow	yellow	yellow	red	yellow
LRRC2	yellow	yellow	yellow	yellow	yellow
BCL11A	yellow	yellow	yellow	red	yellow
FOXO3	yellow	yellow	yellow	gray	yellow
SESN1	yellow	yellow	yellow	yellow	yellow
DGAT2	yellow	yellow	yellow	yellow	yellow
COL9A3	yellow	yellow	yellow	gray	yellow
USP7	yellow	yellow	yellow	yellow	yellow
C6orf123	yellow	yellow	yellow	yellow	yellow
LAPTM4B	yellow	yellow	yellow	yellow	yellow
ZFAS1	yellow	yellow	yellow	yellow	yellow
FER1L4	yellow	yellow	yellow	yellow	yellow
MAP1LC3A	yellow	yellow	yellow	gray	yellow
CTSA	yellow	yellow	yellow	yellow	yellow
SDC4	yellow	yellow	yellow	yellow	yellow
GPR56	yellow	yellow	yellow	yellow	yellow
CACNA1D	yellow	yellow	yellow	yellow	yellow
EPDR1	yellow	yellow	yellow	yellow	yellow
PROX1	yellow	yellow	yellow	yellow	yellow
DACH1	yellow	yellow	yellow	red	yellow
DUSP18	yellow	yellow	yellow	red	yellow
PTCH1	yellow	yellow	yellow	red	yellow
RLN2	yellow	yellow	yellow	yellow	yellow
BCL2L1	yellow	yellow	yellow	gray	yellow
PRDX5	yellow	yellow	green	red	yellow
SHANK2	yellow	yellow	yellow	yellow	yellow
KHDRBS3	yellow	yellow	yellow	yellow	yellow
GYG2	yellow	yellow	yellow	yellow	yellow
IL22RA1	yellow	yellow	yellow	yellow	yellow
PAH	yellow	yellow	yellow	yellow	yellow
DUSP16	yellow	yellow	green	red	yellow
NONO	yellow	gray	yellow	yellow	yellow
NCOA3	yellow	yellow	yellow	yellow	yellow
ETV4	yellow	yellow	yellow	yellow	yellow
SPIRE2	yellow	yellow	yellow	yellow	yellow
ANO9	yellow	yellow	yellow	yellow	yellow
ENGASE	yellow	yellow	yellow	yellow	yellow
GAS2	yellow	yellow	yellow	yellow	yellow
PIPOX	yellow	yellow	yellow	yellow	yellow
CYP2B6	yellow	yellow	green	red	yellow
ELMO2	yellow	yellow	yellow	yellow	yellow
NKD1	yellow	yellow	yellow	yellow	yellow
DPEP1	yellow	yellow	yellow	red	yellow
ZNRF3	yellow	yellow	yellow	red	yellow
C7orf13	yellow	yellow	yellow	yellow	yellow
SLC7A6	yellow	yellow	yellow	yellow	yellow
TLE2	yellow	yellow	yellow	yellow	yellow
EMILIN3	yellow	yellow	yellow	yellow	yellow
EPB41L1	yellow	yellow	yellow	yellow	yellow
MAP7D2	yellow	yellow	yellow	yellow	yellow
REPIN1	yellow	yellow	yellow	red	yellow
PM20D2	yellow	yellow	yellow	yellow	yellow
CRCP	yellow	gray	yellow	yellow	yellow
GGH	yellow	yellow	yellow	red	yellow
ABAT	yellow	yellow	yellow	yellow	yellow
C11orf95	yellow	yellow	yellow	yellow	yellow
ZNF217	yellow	yellow	yellow	yellow	yellow
CHN2	yellow	yellow	yellow	yellow	yellow
GSE1	yellow	yellow	yellow	yellow	yellow
RBP2	yellow	yellow	yellow	yellow	yellow
SHROOM2	yellow	yellow	yellow	yellow	yellow
AKAP1	yellow	yellow	yellow	yellow	yellow
STOX1	yellow	yellow	yellow	yellow	yellow
SLC19A3	yellow	yellow	yellow	gray	yellow
ACSL6	yellow	yellow	yellow	yellow	yellow
CASK	yellow	gray	yellow	yellow	yellow
CTPS2	yellow	yellow	yellow	yellow	yellow
HSPH1	yellow	yellow	yellow	yellow	yellow
GTF2F2	yellow	gray	yellow	yellow	yellow
NDFIP2	yellow	yellow	yellow	yellow	yellow
TMTC4	yellow	yellow	yellow	yellow	yellow
UCHL3	yellow	yellow	yellow	gray	yellow
SPATA13	yellow	yellow	yellow	yellow	yellow
NEK3	yellow	yellow	yellow	yellow	yellow
PROSER1	yellow	yellow	yellow	yellow	yellow
WDR35	yellow	yellow	yellow	yellow	yellow
ZNF514	yellow	yellow	yellow	yellow	yellow
CBFA2T2	yellow	yellow	yellow	yellow	yellow
ZMYND8	yellow	yellow	yellow	yellow	yellow
CHD6	yello	yellow	yello	yellow	yello
PABPC1L	yello	yellow	yello	yellow	yello
RAB22A	yello	yellow	yello	yellow	yello
LINC00657	yello	yellow	yello	yellow	yello
RBM39	yello	yellow	yello	yellow	yello
ARFGEF2	yello	yellow	yello	yellow	yello
PCMTD2	yello	yellow	yello	yellow	yello
STX16	yello	gray	yello	yellow	yello
EREG	yello	yellow	yello	yellow	yello
GGT7	yello	yellow	yello	yellow	yello
PARD6B	yello	yellow	yello	yellow	yello
TOP1	yello	gray	yello	yellow	yello
YAE1D1	yello	yellow	yello	yellow	yello
MYC	yello	yellow	yello	yellow	yello
TNNC2	yello	yellow	yello	yellow	yello
CEL	yello	yellow	yello	yellow	yello
CELP	yello	yellow	yello	yellow	yello
ZDHHC9	yello	yellow	yello	yellow	yello
HUNK	yello	yellow	yello	red	yello
AXIN2	yello	yellow	yello	red	yello
ASCL2	yello	yellow	yello	red	yello
RNF43	yello	yellow	yello	red	yello
QPRT	yello	yellow	yello	yellow	yello
TSPAN6	yello	yellow	gree	red	yello
VAV3	yello	yellow	gree	red	yello
NEU1	yello	yellow	yello	yellow	yello
C8orf33	yello	yellow	yello	yellow	yello
PLA2G12B	yello	yellow	yello	yellow	yello
GTF2IRD1	yello	yellow	yello	yellow	yello
POFUT1	yello	yellow	yello	yellow	yello
KRT23	yello	yellow	yello	yellow	yello
ARID3A	yello	yellow	yello	yellow	yello
CABLES2	yello	yellow	yello	yellow	yello
SERINC3	yello	yellow	yello	yellow	yello
GNG4	yello	yellow	yello	yellow	yello
GPR143	yello	yellow	yello	yellow	yello
SPATA2	yello	yellow	yello	yellow	yello
MOCS3	yello	gray	yello	yellow	yello
NDRG3	yello	gray	yello	yellow	yello
TTPAL	yello	yellow	yello	yellow	yello
ATP9A	yello	yellow	yello	yellow	yello
CHMP4B	yello	yellow	yello	yellow	yello
COMMD7	yello	yellow	yello	yellow	yello
EIF2S2	yello	yellow	yello	yellow	yello
TCFL5	yello	yellow	yello	yellow	yello
DSN1	yello	gray	yello	gray	yello
SLMO2	yello	yellow	yello	yellow	yello
CSE1L	yellow	yellow	yellow	yellow	yellow
DPM1	yellow	yellow	yellow	yellow	yellow
PFDN4	yellow	yellow	yellow	yellow	yellow
ACOT8	yellow	yellow	yellow	yellow	yellow
DHX35	yellow	yellow	yellow	yellow	yellow
PXMP4	yellow	yellow	yellow	yellow	yellow
AHCY	yellow	yellow	yellow	yellow	yellow
MRGBP	yellow	gray	yellow	gray	yellow
AURKA	yellow	gray	yellow	gray	yellow
TPX2	yellow	gray	yellow	gray	yellow
UBE2C	yellow	gray	yellow	gray	yellow
SLC5A6	yellow	yellow	yellow	yellow	yellow
FITM2	yellow	yellow	yellow	yellow	yellow
TM9SF4	yellow	yellow	yellow	yellow	yellow
UCKL1	yellow	yellow	yellow	yellow	yellow
DNTTIP1	yellow	yellow	yellow	yellow	yellow
RNF114	yellow	yellow	yellow	yellow	yellow
GSS	yellow	yellow	yellow	yellow	yellow
SCAND1	yellow	yellow	yellow	yellow	yellow
TP53RK	yellow	yellow	yellow	yellow	yellow
ADRM1	yellow	yellow	yellow	yellow	yellow
TOMM34	yellow	yellow	yellow	yellow	yellow
RPS21	yellow	yellow	yellow	yellow	yellow
CPNE1	yellow	yellow	yellow	yellow	yellow
ASXL1	yellow	yellow	yellow	yellow	yellow
ROMO1	yellow	yellow	yellow	yellow	yellow
RAE1	yellow	yellow	yellow	yellow	yellow
VAPB	yellow	yellow	yellow	yellow	yellow
ERGIC3	yellow	yellow	yellow	yellow	yellow
PLAGL2	yellow	yellow	yellow	yellow	yellow
DYNLRB1	yellow	yellow	yellow	yellow	yellow
TTI1	yellow	yellow	yellow	yellow	yellow
PRPF6	yellow	yellow	yellow	yellow	yellow
YTHDF1	yellow	yellow	yellow	yellow	yellow
DDX27	yellow	yellow	yellow	yellow	yellow
EIF6	yellow	yellow	yellow	yellow	yellow
PIGU	yellow	yellow	yellow	yellow	yellow
NELFCD	yellow	yellow	yellow	yellow	yellow
CTNNBL1	yellow	yellow	yellow	yellow	yellow
PSMA7	yellow	yellow	yellow	yellow	yellow
KIF3B	yellow	yellow	yellow	yellow	yellow
FAM217B	yellow	yellow	yellow	yellow	yellow
PPP1R3D	yellow	yellow	yellow	yellow	yellow
DIDO1	yellow	yellow	yellow	yellow	yellow
STK4	yellow	yellow	yellow	yellow	yellow
YWHAB	yellow	yellow	yellow	yellow	yellow
LPAR3	red	gray	gray	gray	red
PF4	red	gray	gray	red	red
SDC1	red	gray	green	red	red
TMEM2	red	gray	red	red	red
IGFBP2	red	gray	green	gray	red
FOXA1	red	gray	gray	gray	red
RRN3P1	red	gray	gray	red	red
CEACAM8	red	gray	green	red	red
GIF	red	magenta	green	red	red
C1orf116	red	magenta	green	red	red
RELL1	red	gray	gray	red	red
UBXN10	red	gray	gray	red	red
ZFP3	red	gray	green	red	red
SLC35G1	red	gray	gray	gray	red
HES1	red	gray	green	gray	red
FAIM2	red	gray	gray	gray	red
KCNN4	red	gray	green	red	red
GAL3ST1	red	red	green	red	red
METTL7B	red	red	green	red	red
SLC9A3R1	red	gray	gray	red	red
COBL	red	gray	gray	gray	red
LTK	red	gray	gray	gray	red
ENTPD2	red	gray	green	gray	red
MAP3K13	red	gray	green	gray	red
TM4SF20	red	gray	gray	red	red
CCL24	red	gray	gray	red	red
CHST4	red	gray	gray	gray	red
EGF	red	red	gray	gray	red
DEFA5	red	greenyellow	green	red	red
DEFA6	red	greenyellow	green	red	red
LYPD6B	red	gray	gray	gray	red
DNAJC12	red	gray	gray	gray	red
PCSK1	red	magenta	gray	gray	red
NTN4	red	greenyellow	gray	gray	red
SMAD9	red	gray	green	gray	red
GPR128	red	gray	gray	gray	red
PCCA	red	magenta	green	red	red
COL4A5	red	greenyellow	green	gray	red
CASZ1	red	gray	red	gray	red
OTC	red	gray	green	gray	red
REG3A	red	magenta	red	gray	red
REG1P	red	magenta	red	gray	red
REG1A	red	magenta	red	gray	red
REG1B	red	magenta	red	gray	red
CAPN12	red	gray	red	red	red
C21orf33	red	gray	gray	red	red
LONRF3	red	magenta	red	gray	red
PRKAG2-AS1	red	gray	gray	gray	red
SOSTDC1	red	gray	gray	red	red
RNF183	red	magenta	red	gray	red
ZC3H12D	red	gray	gray	red	red
HR	red	gray	gray	red	red
TMED6	red	red	gray	red	red
PCDH20	red	gray	green	gray	red
AKR1C3	red	gray	green	red	red
TSPAN7	red	greenyellow	green	gray	red
CYCS	red	gray	green	gray	red
C4BPA	red	red	red	red	red
TM4SF5	red	red	green	red	red
TLE1	red	magenta	red	gray	red
NDNF	red	red	green	gray	red
ACOT13	red	red	green	red	red
ACAA2	red	red	gray	red	red
MKNK2	red	gray	gray	red	red
C1orf226	red	magenta	gray	red	red
NEO1	red	red	green	red	red
MTMR11	red	red	green	red	red
PVRL3	red	red	green	red	red
DEFB1	red	gray	gray	gray	red
SLC16A5	red	gray	green	red	red
ARHGAP27	red	gray	gray	red	red
ERBB2	red	gray	green	red	red
RAPGEFL1	red	red	green	red	red
PROM1	red	gray	gray	red	red
DHRS1	red	gray	red	gray	red
NOXO1	red	red	green	gray	red
C2orf82	red	red	green	red	red
SMAGP	red	red	green	red	red
TMEM141	red	red	green	gray	red
ABHD14B	red	gray	green	red	red
BAIAP2L2	red	gray	green	red	red
STARD10	red	gray	green	red	red
ASL	red	red	green	red	red
CLN3	red	gray	green	red	red
FAAH	red	gray	green	red	red
NOS2	red	gray	gray	gray	red
TRIM15	red	gray	gray	gray	red
KCNE3	red	gray	green	red	red
SCIN	red	magenta	green	red	red
GSTA1	red	gray	green	gray	red
COL17A1	red	gray	green	red	red
NPY6R	red	gray	gray	gray	red
NQO1	red	red	green	red	red
CAPN8	red	red	green	gray	red
MXD1	red	gray	green	gray	red
TRIM31	red	red	green	red	red
ALDH6A1	red	gray	red	red	red
CYP2C18	red	gray	red	gray	red
CYP2C9	red	gray	red	gray	red
WFDC2	red	red	green	gray	red
ANXA13	red	magenta	green	red	red
C1orf115	red	red	gray	red	red
PRSS16	red	gray	red	gray	red
GDA	red	magenta	red	gray	red
ADORA2B	red	gray	red	gray	red
APOBEC1	red	red	green	red	red
MAP2K6	red	gray	green	red	red
EMP2	red	red	green	red	red
TRHDE	red	red	green	red	red
VWA5A	red	red	green	gray	red
PPARGC1A	red	gray	green	red	red
UGT2A3	red	red	green	red	red
CNTN3	red	greenyellow	green	gray	red
HAPLN1	red	gray	gray	gray	red
BMP5	red	greenyellow	gray	gray	red
FAM150B	red	greenyellow	green	gray	red
ITGA8	red	greenyellow	gray	gray	red
ADAMDEC1	red	greenyellow	gray	gray	red
DNASE1L3	red	greenyellow	gray	gray	red
METTL7A	red	gray	green	gray	red
SEPP1	red	greenyellow	green	gray	red
LPHN3	red	greenyellow	green	red	red
BBIP1	red	greenyellow	green	red	red
PRKACB	red	greenyellow	green	gray	red
PCSK6	red	gray	red	red	red
SLPI	red	magenta	red	gray	red
L1TD1	red	magenta	red	gray	red
GNA14	red	magenta	red	gray	red
NEDD9	red	magenta	red	gray	red
TPK1	red	gray	gray	gray	red
GAREM	red	magenta	gray	gray	red
CNGA1	red	red	green	red	red
ADH6	red	red	green	red	red
CMBL	red	magenta	red	red	red
ATP1B1	red	gray	red	gray	red
NPDC1	red	magenta	red	gray	red
COL9A2	red	red	red	gray	red
TMEM45B	red	red	gray	red	red
BLNK	red	magenta	red	gray	red
TMEM92	red	magenta	red	gray	red
BACE2	red	magenta	red	red	red
RASAL1	red	magenta	red	gray	red
LINC00668	red	red	green	gray	red
AXDND1	red	red	green	red	red
COL4A6	red	greenyellow	green	gray	red
SLC6A14	red	magenta	red	gray	red
IRF6	red	gray	green	red	red
ASS1	red	magenta	gray	gray	red
GSDMB	red	gray	gray	gray	red
SGPP2	red	gray	gray	gray	red
RORC	red	red	red	red	red
3-Mar	red	magenta	red	gray	red
CLDN23	red	greenyellow	green	red	red
CDHR2	red	gray	green	red	red
MALL	red	red	green	gray	red
LRG1	red	magenta	red	gray	red
PTPRF	red	gray	green	red	red
SERINC2	red	red	green	red	red
WNT4	red	red	gray	red	red
S100P	red	magenta	red	gray	red
OVOL2	red	gray	green	red	red
TMEM37	red	greenyellow	green	gray	red
TUBAL3	red	red	green	red	red
EPHX2	red	red	red	red	red
GBA3	red	gray	green	gray	red
NR1H4	red	gray	green	gray	red
TMEM254	red	gray	green	gray	red
HOXB13	red	gray	red	red	red
C1orf21	red	magenta	red	gray	red
ALDOB	red	red	green	gray	red
LGALS2	red	gray	green	gray	red
PDCD6IP	red	gray	gray	red	red
ZG16B	red	red	red	gray	red
TMPRSS4	red	red	green	red	red
SLC5A1	red	red	green	red	red
SLC44A3	red	red	green	red	red
PLEKHA6	red	red	green	gray	red
STAP2	red	red	green	red	red
MAOA	red	red	green	red	red
ANKS4B	red	red	green	red	red
NRARP	red	red	green	red	red
BDH1	red	red	green	red	red
HADH	red	red	green	red	red
PPP1R1B	red	red	green	red	red
FUT3	red	gray	green	red	red
FUT6	red	red	green	red	red
TMC4	red	red	green	red	red
BCL2L14	red	red	green	red	red
ATP2C2	red	red	green	red	red
TTC39A	red	red	green	red	red
FZD5	red	red	green	red	red
CORO2A	red	red	green	red	red
CALML4	red	red	green	red	red
PIP5K1B	red	red	green	red	red
CLRN3	red	red	green	red	red
MUC13	red	red	red	red	red
PRR15L	red	red	green	red	red
HDHD3	red	red	green	red	red
USH1C	red	red	green	red	red
DMBT1	red	magenta	red	red	red
BCL2L15	red	red	green	red	red
LCN2	red	red	red	gray	red
PDZK1IP1	red	red	red	red	red
HGD	red	red	red	red	red
HMGN2P46	red	magenta	green	red	red
MMP28	red	magenta	gray	red	red
ALDH1L1	red	gray	red	gray	red
DQX1	red	red	gray	red	red
TMEM171	red	gray	red	gray	red
FUT2	red	red	red	red	red
ACSM3	red	red	green	red	red
NDRG2	red	red	green	gray	red
GOLM1	red	red	red	red	red
SYTL5	red	red	green	red	red
TRPM4	red	red	green	red	red
PI3	red	magenta	red	gray	red
CRYM	red	red	green	red	red
CLMN	red	red	green	red	red
PRSS12	red	magenta	gray	red	red
C1orf210	red	gray	gray	red	red
ABCC3	red	red	gray	red	red
PIGR	red	red	red	gray	red
SLC28A2	red	red	green	gray	red
BMP2	red	magenta	red	gray	red
TRPA1	red	greenyellow	green	red	red
NUDT16	red	magenta	red	red	red
SCNN1A	red	red	red	red	red
TMEM246	red	magenta	red	gray	red
SLITRK6	red	magenta	red	gray	red
CATSPERB	red	magenta	red	gray	red
AMN	red	magenta	gray	gray	red
FRMD3	red	magenta	gray	gray	red
TSPAN3	red	gray	red	red	red
CHP1	red	gray	red	gray	red
HSD17B2	red	red	gray	gray	red
GCNT3	red	magenta	red	gray	red
LIPH	red	magenta	gray	gray	red
PPP1R36	red	red	red	red	red
GALNT12	red	magenta	red	red	red
KIAA1324	red	magenta	red	red	red
C9orf152	red	red	green	red	red
FOXA3	red	red	red	red	red
MUC5B	red	magenta	red	gray	red
TCEA3	red	magenta	green	red	red
RETNLB	red	red	green	red	red
SLC9A2	red	red	green	red	red
C2orf72	red	magenta	red	gray	red
PTGER4	red	red	red	gray	red
PDXDC1	red	gray	red	red	red
PLD1	red	red	red	gray	red
SHROOM3	red	magenta	red	red	red
TSPAN13	red	magenta	red	gray	red
IQGAP2	red	magenta	red	gray	red
DSC2	red	gray	red	red	red
CAMK2D	red	gray	gray	gray	red
ATP8A1	red	magenta	red	gray	red
SLC2A13	red	magenta	red	red	red
PAPSS2	red	magenta	red	red	red
LGR4	red	magenta	red	red	red
TNFRSF11A	red	magenta	red	gray	red
STYK1	red	magenta	red	gray	red
CCDC68	red	magenta	gray	gray	red
CASP7	red	magenta	red	gray	red
LIMA1	red	red	red	gray	red
ABHD3	red	gray	red	gray	red
GSKIP	red	magenta	red	gray	red
TC2N	red	magenta	gray	gray	red
SMIM14	red	magenta	red	gray	red
LAMA1	red	magenta	gray	red	red
ASRGL1	red	magenta	red	gray	red
TFF3	red	red	red	red	red
GNE	red	magenta	red	gray	red
RNASE4	red	magenta	red	gray	red
TFF1	red	magenta	red	gray	red
PTGER2	red	magenta	red	gray	red
RHBDL2	red	magenta	red	red	red
MB	red	magenta	red	gray	red
RAP1GAP	red	magenta	red	gray	red
AGR2	red	magenta	red	gray	red
AGR3	red	magenta	red	gray	red
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SIDT1	red	magenta	red	gray	red
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ENTPD5	red	red	green	re	red
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XDH	red	red	red	re	red
CES3	red	red	red	re	red
AHCYL2	red	gray	red	re	red
AKR1B10	red	red	green	re	red
SIAE	red	gray	red	re	red
ATP8B1	red	gray	red	re	red
RBM47	red	gray	red	re	red
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MFSD4	red	red	green	red	red
PLAC8	red	magenta	red	gray	red
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GCG	red	greenyellow	green	gray	red
ADH1C	red	red	green	red	red
ABCC13	red	red	green	red	red
DHRS9	red	gray	green	gray	red
ADTRP	red	red	green	gray	red
ITM2C	red	gray	red	red	red
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TSPAN1	red	red	red	red	red
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CLCA1	red	red	red	red	red
CCL28	red	red	red	red	red
VSIG2	red	red	red	red	red
SPINK5	red	red	green	gray	red
C2orf88	red	greenyellow	green	red	red
SI	red	red	green	gray	red
SCNN1B	red	gray	green	red	red
CLDN8	red	gray	green	gray	red
CD177	red	gray	green	gray	red
GUCA2B	red	red	green	gray	red
CLCA4	red	red	green	red	red
MS4A12	red	red	green	red	red
CA1	red	red	green	gray	red
CA4	red	red	green	gray	red
ZG16	red	red	green	red	red
CA2	red	gray	red	gray	red
SLC4A4	red	magenta	red	gray	red
MGST1	red	gray	gray	gray	red
GATA6	red	gray	gray	red	red
PPARGC1B	red	gray	gray	red	red
KBTBD11	red	red	gray	red	red
PLEKHH1	red	red	gray	red	red
SH3RF2	red	red	red	red	red
SLC39A8	red	magenta	red	red	red
UQCRC2	red	gray	red	red	red
DNAJC22	red	red	green	gray	red
NEDD4L	red	gray	red	red	red
C3orf52	red	magenta	red	gray	red
ARHGAP32	red	gray	red	red	red
ELL3	red	magenta	gray	gray	red
LRRC16A	red	gray	gray	gray	red
EHHADH	red	gray	green	red	red
TRIM36	red	gray	red	red	red
MYO5C	red	gray	gray	gray	red
TTC19	red	gray	red	gray	red
HK2	red	gray	red	gray	red
BCL10	red	gray	red	red	red
F2RL1	red	red	red	gray	red
ELOVL6	red	gray	gray	gray	red
FRK	red	gray	gray	gray	red
MCTP2	red	gray	red	gray	red
SLC27A2	red	gray	red	gray	red
AFG3L2	red	magenta	gray	gray	red
PKP2	red	gray	red	gray	red
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MSX2	turquoise	turquoise	gray	gray
TBX3	brown	green	gray	gray
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DKK4	turquoise	gray	gray	turquoise
SP5	brown	gray	gray	gray
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FGB	turquoise	gray	gray	gray
CD99P1	turquoise	gray	gray	turquoise
ONECUT2	turquoise	gray	gray	gray
AIM1L	turquoise	gray	gray	turquoise
IQCE	black	gray	gray	gray
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SPNS2	black	black	black	gray
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FOLR1	turquoise	turquoise	gray	gray
SOX1	turquoise	gray	gray	turquoise
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PTPRN2	turquoise	gray	turquoise	gray
SOX6	turquoise	gray	turquoise	turquoise
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AGFG2	brown	green	gray	gray
AMFR	black	gray	gray	gray
HMBOX1	turquoise	gray	gray	turquoise
GRIN2D	brown	gray	gray	gray
KDELR1	turquoise	gray	gray	turquoise
LPHN1	turquoise	gray	gray	turquoise
NSMF	brown	gray	gray	brown
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ARHGDIA	turquoise	gray	gray	turquoise
MAZ	brown	green	gray	brown
GNB2	black	gray	gray	gray
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OGDH	turquoise	gray	gray	gray
URGCP	turquoise	gray	gray	gray
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NFIA	turquoise	gray	gray	gray
ECHDC2	turquoise	gray	gray	turquoise
RHOU	turquoise	gray	gray	turquoise
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RERE	turquoise	gray	turquoise	turquoise
EP400	green	gray	yellow	yellow
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ARMCX4	turquoise	turquoise	gray	gray
PON3	turquoise	gray	turquoise	gray
CLGN	turquoise	turquoise	gray	turquoise
SHC3	turquoise	turquoise	gray	turquoise
CA9	black	gray	gray	gray
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NMU	turquoise	gray	turquoise	gray
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DAPP1	black	black	black	black
GTSE1	brown	brown	gray	brown
AKR1C4	turquoise	gray	gray	gray
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C12orf56	turquoise	gray	turquoise	gray
PEX6	turquoise	gray	turquoise	gray
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NOS3	turquoise	gray	turquoise	turquoise
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PPP2R2C	turquoise	gray	gray	gray
WFS1	turquoise	gray	turquoise	gray
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AGA	black	gray	gray	gray
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WDR72	turquoise	gray	turquoise	gray
IL17A	turquoise	gray	gray	gray
DPP10	turquoise	gray	turquoise	turquoise
MTTP	turquoise	gray	turquoise	gray
MXI1	turquoise	gray	turquoise	turquoise
SLC38A11	turquoise	gray	gray	turquoise
DSC3	turquoise	turquoise	turquoise	turquoise
HOXB-AS3	turquoise	turquoise	turquoise	turquoise
HOXB9	yellow	yellow	green	gray
HOXB8	turquoise	turquoise	gray	gray
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HOXB3	turquoise	turquoise	turquoise	gray
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TESC	turquoise	gray	turquoise	turquoise
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HOXA7	turquoise	turquoise	gray	turquoise
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PRKCA	turquoise	gray	gray	turquoise
SLC38A5	black	gray	gray	gray
TIMP4	turquoise	gray	gray	gray
FAM118A	turquoise	gray	gray	turquoise
GSTM4	black	gray	black	black
ERAP1	black	black	black	gray
SYNPR	turquoise	turquoise	gray	turquoise
CHST13	turquoise	gray	gray	gray
CYP4V2	black	black	black	gray
ZNF334	turquoise	turquoise	turquoise	turquoise
WIPI1	turquoise	gray	gray	gray
IL33	turquoise	turquoise	turquoise	turquoise
NTS	turquoise	turquoise	turquoise	turquoise
TNIK	turquoise	gray	gray	gray
SPAG4	turquoise	gray	turquoise	turquoise
CTBP1	turquoise	gray	gray	turquoise
CLDN10	turquoise	gray	turquoise	turquoise
ORM1	turquoise	gray	turquoise	gray
GPR37	turquoise	gray	gray	turquoise
CTTN	black	black	black	gray
ITGB8	turquoise	turquoise	gray	turquoise
PTGR1	black	gray	gray	gray
SCD5	turquoise	turquoise	gray	turquoise
TRIM4	turquoise	gray	turquoise	turquoise
NUCKS1	turquoise	gray	gray	gray
ZC3HAV1	turquoise	gray	gray	gray
EGFR	turquoise	gray	gray	gray
SRGAP1	turquoise	gray	gray	gray
SALL1	turquoise	gray	gray	gray
GRB14	black	gray	gray	gray
LGSN	turquoise	gray	turquoise	turquoise
GLDN	black	gray	black	gray
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ATHL1	turquoise	turquoise	gray	turquoise
ALDH1B1	turquoise	gray	gray	gray
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C6orf141	black	gray	gray	gray
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KCNQ1OT1	turquoise	turquoise	turquoise	turquoise
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MTSS1	turquoise	turquoise	turquoise	turquoise
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CELSR1	turquoise	turquoise	gray	turquoise
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KANSL1-AS1	black	gray	gray	gray
OLFM1	turquoise	turquoise	turquoise	turquoise
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GPR64	turquoise	turquoise	turquoise	turquoise
NDRG1	turquoise	gray	gray	turquoise
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C2orf68	turquoise	gray	gray	gray
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MMP10	black	black	black	black
RPS23	turquoise	gray	gray	turquoise
MFI2	turquoise	turquoise	gray	turquoise
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ZBED1	turquoise	gray	gray	turquoise
H2AFY2	turquoise	gray	turquoise	turquoise
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PRR9	turquoise	gray	gray	turquoise
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IRX2	turquoise	gray	gray	gray
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HIST1H1C	black	black	black	black
HIST1H2BH	black	black	gray	gray
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PXN	turquoise	gray	gray	turquoise
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SFN	black	gray	black	gray
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GPRC5A	black	gray	gray	gray
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CLTB	black	gray	gray	gray
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ISL1	black	black	black	black
ARX	black	magenta	black	black
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HSPA4L	brown	brown	gray	brown
RPL22L1	black	gray	black	gray
CAPN6	turquoise	turquoise	turquoise	turquoise
ZNF844	turquoise	turquoise	turquoise	turquoise
TMEM99	turquoise	turquoise	gray	turquoise
MYEOV	black	black	black	gray
TMEM150C	turquoise	turquoise	gray	turquoise
DPP4	black	black	black	black
CYP27A1	turquoise	gray	gray	turquoise
PRSS21	black	black	black	black
KIF1C	turquoise	gray	gray	gray
SERPIND1	turquoise	gray	gray	turquoise
BEX5	black	black	black	gray
TKTL1	turquoise	gray	gray	gray
ALPK3	turquoise	turquoise	turquoise	turquoise
CFB	black	black	black	black
SYT17	turquoise	gray	gray	turquoise
TPPP	black	magenta	black	gray
EFNB2	turquoise	gray	turquoise	gray
EPHB1	turquoise	turquoise	turquoise	turquoise
MAEL	turquoise	gray	turquoise	turquoise
ZNF862	turquoise	turquoise	turquoise	gray
PRRC2B	turquoise	gray	gray	gray
CELF2	turquoise	gray	turquoise	turquoise
SLC39A14	black	gray	black	gray
MCOLN3	turquoise	gray	turquoise	turquoise
CLN8	black	gray	gray	gray
C8orf4	turquoise	gray	turquoise	turquoise
TBXAS1	black	black	gray	gray
SULT1C4	turquoise	gray	gray	gray
MME	turquoise	turquoise	turquoise	turquoise
ZIC2	black	magenta	black	gray
APOA2	turquoise	gray	gray	gray
TPPP3	turquoise	gray	gray	turquoise
SERP2	turquoise	gray	turquoise	turquoise
ARHGEF9	turquoise	gray	gray	turquoise
CNKSR3	turquoise	gray	turquoise	turquoise
PTGDR	black	black	black	black
TSHZ1	turquoise	turquoise	turquoise	turquoise
TCAM1P	turquoise	gray	gray	gray
IRX3	black	black	black	gray
C2	black	black	black	gray
MVB12A	black	black	black	gray
RRAS2	turquoise	gray	turquoise	turquoise
LGALS9	black	black	black	black
ASPHD1	black	gray	black	gray
GAL	turquoise	turquoise	turquoise	turquoise
SLC4A11	black	black	black	gray
PTPN13	turquoise	turquoise	gray	turquoise
MAGEA12	turquoise	gray	gray	turquoise
TMEFF2	turquoise	gray	gray	turquoise
KLHL29	turquoise	gray	gray	turquoise
NOD2	turquoise	turquoise	turquoise	turquoise
ACOT4	black	gray	gray	gray
MYBL1	black	black	black	gray
ZNF43	turquoise	turquoise	gray	turquoise
DLL1	turquoise	gray	gray	turquoise
FZD10	turquoise	turquoise	turquoise	turquoise
WWOX	turquoise	turquoise	gray	gray
PTPN1	turquoise	gray	gray	turquoise
LARP6	turquoise	turquoise	gray	turquoise
LDLRAD3	turquoise	gray	gray	turquoise
XIST	turquoise	gray	turquoise	gray
HLTF	turquoise	turquoise	turquoise	turquoise
DMKN	black	magenta	black	black
TNNC1	turquoise	turquoise	turquoise	turquoise
IL2RG	black	black	gray	black
TMEM154	black	gray	gray	black
TPGS1	black	black	gray	black
GPC3	black	gray	gray	black
PRKCQ	black	black	black	black
HP1BP3	turquoise	gray	turquoise	turquoise
SYT1	turquoise	gray	gray	turquoise
KCNMB4	turquoise	turquoise	turquoise	turquoise
NFIB	turquoise	gray	turquoise	turquoise
RTN3	turquoise	gray	gray	turquoise
TSPAN5	turquoise	turquoise	gray	turquoise
XCL1	black	black	black	gray
TNFSF11	turquoise	gray	gray	turquoise
RUFY2	black	gray	black	black
FOXD1	black	black	black	gray
FREM1	turquoise	turquoise	gray	gray
RUNDC3B	turquoise	turquoise	turquoise	turquoise
ZNF185	turquoise	turquoise	turquoise	gray
KIAA0125	black	black	black	black
PPL	turquoise	gray	turquoise	turquoise
LMF1	turquoise	gray	turquoise	turquoise
FLRT3	black	black	black	black
LUZP1	turquoise	turquoise	gray	turquoise
SLC2A1	turquoise	turquoise	gray	turquoise
ARPC4	black	gray	black	gray
ABHD2	turquoise	gray	turquoise	turquoise
HHLA3	black	gray	black	black
EDN1	turquoise	gray	gray	turquoise
SATB1	turquoise	turquoise	gray	turquoise
RAPGEF4	turquoise	turquoise	turquoise	turquoise
DDX43	turquoise	gray	gray	gray
PSTPIP2	turquoise	gray	gray	turquoise
LEMD1	turquoise	turquoise	gray	turquoise
PVRL2	turquoise	gray	gray	gray
FRMD5	black	black	gray	gray
GAD1	black	magenta	black	gray
GSTZ1	black	gray	black	gray
MPI	black	gray	black	black
KPNA6	black	gray	gray	gray
MOV10	black	gray	black	gray
UAP1L1	black	gray	black	black
CDK2AP2	black	gray	black	gray
LPCAT1	black	magenta	black	gray
BSG	black	gray	black	gray
MIB2	black	gray	black	gray
TNFSF9	black	gray	black	gray
CBR3	black	magenta	black	black
ACIN1	black	gray	black	gray
AKT1	black	gray	black	gray
CALR	black	gray	black	black
PFKP	black	gray	black	gray
P4HB	black	gray	black	gray
PKM	black	black	black	gray
CDC42EP1	black	gray	black	gray
PFN1	black	gray	black	gray
RNF19B	black	gray	black	gray
GPATCH2	turquoise	gray	gray	turquoise
HORMAD1	turquoise	gray	gray	turquoise
DSG3	turquoise	turquoise	turquoise	turquoise
NPY1R	black	gray	gray	gray
SIPA1L2	turquoise	gray	gray	turquoise
BRD2	turquoise	gray	gray	gray
IL27RA	black	gray	black	black
IRF8	black	black	black	black
GALC	turquoise	turquoise	turquoise	turquoise
TGFA	black	gray	gray	gray
COCH	turquoise	gray	gray	turquoise
IQGAP1	turquoise	gray	gray	gray
BAMBI	turquoise	turquoise	turquoise	turquoise
NFYC	black	gray	black	gray
CYP27B1	black	black	black	black
ZNF117	turquoise	turquoise	turquoise	turquoise
FAM76A	turquoise	gray	turquoise	turquoise
NME5	turquoise	turquoise	turquoise	turquoise
CPLX1	turquoise	turquoise	gray	turquoise
INSM1	black	magenta	black	black
MGMT	turquoise	gray	turquoise	turquoise
INSR	turquoise	gray	gray	turquoise
ERAP2	black	black	black	black
CACHD1	turquoise	turquoise	turquoise	turquoise
CD44	black	magenta	gray	black
ZNF662	turquoise	gray	gray	turquoise
GNAS	turquoise	gray	gray	turquoise
PTPRR	black	black	black	black
HFE	black	gray	black	black
PIWIL1	black	magenta	black	gray
CSRNP3	turquoise	turquoise	turquoise	turquoise
PKDCC	turquoise	turquoise	turquoise	turquoise
GPR155	turquoise	turquoise	gray	turquoise
SKAP1	black	gray	black	gray
IGF1R	turquoise	gray	gray	turquoise
FBXL16	black	magenta	black	black
SOX2	turquoise	gray	gray	gray
LAMP1	turquoise	gray	gray	turquoise
C10orf11	turquoise	gray	gray	turquoise
TNFRSF11B	turquoise	turquoise	turquoise	turquoise
ROBO2	turquoise	gray	gray	turquoise
GSTT1	black	black	gray	black
SQSTM1	turquoise	gray	gray	turquoise
HPGD	black	black	gray	gray
AFAP1L1	black	gray	gray	gray
MAGEA1	black	black	black	black
RBP4	turquoise	turquoise	turquoise	turquoise
S100A10	turquoise	gray	gray	gray
BMP4	turquoise	gray	gray	turquoise
CLN5	black	gray	gray	gray
PLEKHA2	turquoise	gray	gray	turquoise
TGFBI	turquoise	turquoise	gray	turquoise
SPAG9	turquoise	gray	turquoise	turquoise
MSLN	turquoise	turquoise	turquoise	gray
HBEGF	turquoise	gray	gray	turquoise
IGF2BP3	black	black	black	black
PCP4	turquoise	gray	gray	turquoise
NHS	turquoise	turquoise	turquoise	turquoise
TACSTD2	turquoise	turquoise	turquoise	turquoise
2-Mar	black	magenta	gray	black
STXBP1	turquoise	gray	gray	turquoise
ZNF655	turquoise	gray	turquoise	turquoise
TAGAP	black	black	gray	gray
ID3	turquoise	gray	gray	turquoise
FGF18	turquoise	turquoise	gray	turquoise
GJB6	turquoise	gray	gray	gray
STEAP2	turquoise	gray	gray	gray
JUND	turquoise	gray	gray	turquoise
SLC14A1	turquoise	turquoise	turquoise	turquoise
NPTX2	turquoise	turquoise	turquoise	turquoise
IGFBP1	turquoise	turquoise	turquoise	turquoise
F2RL2	turquoise	gray	gray	turquoise
BTBD11	turquoise	turquoise	turquoise	turquoise
GOLGA8A	turquoise	gray	turquoise	turquoise
DNM3	turquoise	turquoise	gray	turquoise
KIF26A	turquoise	gray	turquoise	turquoise
BTG2	turquoise	gray	gray	turquoise
CARD16	black	black	black	black
CASP1	black	black	black	black
NFATC2	turquoise	turquoise	gray	turquoise
KIAA1324L	turquoise	gray	turquoise	turquoise
SORBS2	turquoise	turquoise	turquoise	turquoise
KLHL3	turquoise	gray	gray	turquoise
GSTM3	turquoise	turquoise	turquoise	turquoise
ZNF518B	turquoise	gray	gray	turquoise
RASSF3	turquoise	gray	turquoise	turquoise
APLP2	turquoise	gray	turquoise	turquoise
NLRP2	turquoise	turquoise	gray	turquoise
SLFN13	black	black	black	black
NUB1	black	black	black	black
GABRB3	turquoise	gray	gray	turquoise
TTC9	turquoise	turquoise	gray	turquoise
FAM132B	turquoise	gray	gray	turquoise
EPHA4	turquoise	gray	gray	gray
ZNF697	turquoise	turquoise	gray	turquoise
LAMP2	black	gray	gray	gray
FGF19	turquoise	gray	turquoise	turquoise
TMEM65	turquoise	turquoise	turquoise	turquoise
ABCA17P	black	gray	black	gray
ALDH1A1	turquoise	gray	gray	turquoise
TMCO3	black	gray	black	gray
TMEM64	black	black	black	gray
PCED1A	turquoise	turquoise	gray	turquoise
TMEM71	turquoise	gray	turquoise	turquoise
TFAP2C	black	black	black	gray
PSD3	turquoise	turquoise	turquoise	turquoise
ZNF83	turquoise	turquoise	turquoise	turquoise
GATM	turquoise	turquoise	turquoise	turquoise
FGF9	turquoise	turquoise	gray	turquoise
GSTA4	turquoise	gray	turquoise	turquoise
HOTAIR	black	black	black	gray
PDE4A	turquoise	gray	turquoise	turquoise
WNT5B	turquoise	gray	turquoise	turquoise
HOXA1	turquoise	turquoise	gray	gray
CST3	turquoise	gray	gray	turquoise
CHGB	turquoise	turquoise	turquoise	turquoise
TM4SF4	turquoise	gray	gray	turquoise
CD163L1	black	black	black	black
IL17RD	turquoise	turquoise	turquoise	turquoise
SKAP2	turquoise	turquoise	turquoise	gray
STEAP1	black	black	black	black
ECHDC3	turquoise	gray	turquoise	turquoise
PGM2L1	turquoise	turquoise	turquoise	turquoise
FKBP11	black	black	black	black
ALCAM	turquoise	gray	gray	turquoise
ZNF347	turquoise	turquoise	turquoise	turquoise
DNALI1	turquoise	gray	turquoise	turquoise
DDX58	black	black	black	black
HCP5	black	black	black	gray
RPL39L	turquoise	gray	turquoise	turquoise
FABP3	turquoise	gray	turquoise	turquoise
APOLD1	turquoise	gray	gray	turquoise
CDC42	black	gray	gray	gray
GBP3	black	black	black	black
FBP1	black	black	gray	black
EHD4	black	gray	gray	gray
KRT80	turquoise	turquoise	turquoise	turquoise
OBSCN	turquoise	turquoise	gray	turquoise
ADRB1	black	magenta	black	gray
EMB	black	black	gray	gray
GZMB	black	black	black	black
FGFR2	turquoise	gray	gray	turquoise
GLCCI1	black	black	gray	black
OSR2	black	magenta	black	black
ENPP1	turquoise	turquoise	gray	turquoise
ADPGK	black	gray	black	black
CLIC3	turquoise	turquoise	turquoise	turquoise
PYROXD2	turquoise	gray	gray	turquoise
ZSWIM7	black	black	black	black
ABCG2	black	gray	black	gray
FRAS1	turquoise	gray	turquoise	turquoise
LEPROTL1	black	gray	black	black
GALNT10	turquoise	turquoise	gray	turquoise
DTNA	turquoise	turquoise	turquoise	turquoise
TRIP6	turquoise	gray	turquoise	turquoise
SMPX	turquoise	turquoise	gray	turquoise
RHOF	black	black	black	gray
ADRA2A	turquoise	turquoise	gray	turquoise
SFTA2	turquoise	turquoise	gray	turquoise
SOX8	turquoise	gray	turquoise	turquoise
RGS13	black	black	gray	gray
ADAM22	turquoise	turquoise	gray	turquoise
DOCK11	turquoise	turquoise	turquoise	turquoise
KLK6	turquoise	turquoise	turquoise	turquoise
AKIRIN2	black	gray	black	gray
CDKN1A	black	black	gray	gray
B4GALT1	black	gray	black	gray
ITGA9	turquoise	gray	gray	turquoise
CTSS	black	gray	black	black
KLF13	black	black	black	black
TMCC3	black	gray	black	gray
RASGEF1A	black	black	black	gray
LGALS8	black	black	black	black
ADAMTS15	turquoise	gray	gray	turquoise
HOXD10	turquoise	turquoise	gray	turquoise
HOXD11	turquoise	turquoise	gray	turquoise
OSBPL8	turquoise	turquoise	gray	turquoise
S100A2	turquoise	turquoise	turquoise	turquoise
ZNF559	turquoise	turquoise	turquoise	turquoise
FRZB	turquoise	gray	gray	turquoise
CALB1	black	black	black	black
GUCY1A2	turquoise	turquoise	turquoise	gray
METRN	black	magenta	black	gray
SLC46A3	turquoise	turquoise	gray	turquoise
ARAP3	turquoise	turquoise	turquoise	turquoise
MPP1	turquoise	gray	gray	turquoise
IGHD	black	black	gray	gray
GIMAP2	black	black	black	black
C3orf70	turquoise	turquoise	turquoise	turquoise
PGBD5	turquoise	gray	gray	turquoise
ARHGEF26	turquoise	gray	turquoise	turquoise
SNCAIP	turquoise	turquoise	turquoise	turquoise
HBB	turquoise	gray	turquoise	gray
NT5E	black	magenta	black	black
INTU	turquoise	turquoise	gray	turquoise
ENAH	turquoise	turquoise	turquoise	turquoise
POPDC3	turquoise	gray	turquoise	turquoise
ST6GALNAC2	black	magenta	black	gray
SSR3	black	gray	black	black
SEMA3A	turquoise	turquoise	gray	turquoise
NRN1	turquoise	gray	gray	turquoise
ADAM17	turquoise	gray	gray	turquoise
LAMA3	black	gray	black	black
HHIP	turquoise	gray	turquoise	turquoise
IRAK2	black	black	gray	gray
HIST2H2BE	turquoise	turquoise	turquoise	turquoise
MLF1	turquoise	turquoise	turquoise	turquoise
NR4A2	black	black	black	gray
CRAT	turquoise	turquoise	gray	turquoise
DDIT4	turquoise	gray	gray	turquoise
PLIN2	turquoise	turquoise	turquoise	turquoise
PDE10A	black	gray	black	black
FAM228B	turquoise	turquoise	gray	turquoise
IBSP	turquoise	gray	gray	gray
LEPREL1	turquoise	turquoise	turquoise	turquoise
THRB	turquoise	turquoise	gray	turquoise
OPN3	turquoise	turquoise	gray	turquoise
EPB41L4A	turquoise	turquoise	turquoise	turquoise
SNCA	turquoise	turquoise	turquoise	turquoise
MAN1A1	turquoise	gray	turquoise	turquoise
CDA	turquoise	turquoise	turquoise	turquoise
SERPINE2	turquoise	turquoise	gray	turquoise
GLUD2	black	gray	gray	gray
MMP1	turquoise	gray	turquoise	gray
MMP3	turquoise	gray	turquoise	gray
ETV6	black	gray	black	gray
KRT6B	turquoise	turquoise	turquoise	turquoise
COPA	turquoise	turquoise	gray	turquoise
ZC2HC1A	turquoise	turquoise	gray	turquoise
SMARCA2	turquoise	gray	turquoise	turquoise
PHLDA1	turquoise	gray	gray	turquoise
NQO2	black	gray	black	black
N4BP2L1	black	black	gray	gray
ANKRD29	turquoise	turquoise	turquoise	turquoise
DDX60L	black	black	black	black
TLR3	black	black	black	black
TNFSF10	black	black	black	black
IKZF2	black	black	black	black
PLCL2	black	magenta	black	black
RAB27A	black	magenta	black	black
PCDHB14	turquoise	turquoise	turquoise	turquoise
CNTLN	black	gray	black	gray
FAM13A-AS1	turquoise	gray	gray	gray
DEDD	turquoise	gray	turquoise	turquoise
TNFRSF19	turquoise	turquoise	turquoise	turquoise
PRKAA2	turquoise	turquoise	turquoise	turquoise
ADSSL1	turquoise	gray	gray	turquoise
SRPX2	turquoise	turquoise	gray	turquoise
SNX19	turquoise	gray	turquoise	turquoise
CCL26	turquoise	gray	gray	gray
PELI2	turquoise	turquoise	turquoise	turquoise
ITGB1BP1	turquoise	gray	gray	turquoise
EFNA5	turquoise	gray	gray	turquoise
PRSS23	turquoise	gray	gray	turquoise
ELP5	black	gray	black	black
MMP7	turquoise	turquoise	turquoise	turquoise
VLDLR	turquoise	turquoise	turquoise	turquoise
TMEM220	black	black	black	black
ARRDC4	turquoise	turquoise	turquoise	turquoise
INPP5A	turquoise	gray	gray	turquoise
CTSH	turquoise	gray	gray	turquoise
P4HA1	black	black	black	black
FHOD3	turquoise	gray	gray	turquoise
JAG1	turquoise	gray	gray	turquoise
TAC1	turquoise	gray	gray	turquoise
TJP1	turquoise	gray	turquoise	turquoise
TRNP1	black	magenta	black	gray
ULBP2	black	magenta	black	gray
NELL2	turquoise	gray	gray	turquoise
ARHGAP4	black	black	black	black
RASAL2	turquoise	gray	gray	turquoise
PBX1	turquoise	turquoise	gray	turquoise
PARVB	turquoise	gray	gray	turquoise
SPRR1A	black	gray	black	black
SPRR1B	turquoise	gray	gray	gray
SPRR3	turquoise	turquoise	turquoise	gray
MBD1	black	gray	black	gray
IER5	black	magenta	black	black
RBP1	turquoise	turquoise	turquoise	turquoise
PTGES	turquoise	gray	turquoise	turquoise
GALNT18	turquoise	gray	turquoise	turquoise
WT1	turquoise	turquoise	turquoise	turquoise
ATF3	turquoise	gray	gray	turquoise
NR4A1	turquoise	gray	gray	turquoise
FOS	turquoise	gray	turquoise	turquoise
JUNB	turquoise	gray	turquoise	turquoise
ZFP36	turquoise	gray	turquoise	turquoise
STAT3	turquoise	gray	turquoise	turquoise
ZNF415	turquoise	turquoise	turquoise	turquoise
KRT7	black	magenta	black	gray
TAPBP	black	gray	black	black
KLK10	black	black	gray	gray
PPBP	turquoise	gray	turquoise	turquoise
DYNC1H1	turquoise	gray	gray	turquoise
NAGA	black	gray	black	gray
ZMAT1	turquoise	turquoise	turquoise	turquoise
TACC1	turquoise	turquoise	gray	turquoise
TBL1X	turquoise	gray	gray	turquoise
SOD3	turquoise	turquoise	turquoise	turquoise
HEXIM1	black	black	black	gray
TET1	turquoise	turquoise	turquoise	turquoise
PEG10	turquoise	gray	turquoise	turquoise
DENND5B	black	black	gray	gray
DKK1	turquoise	turquoise	turquoise	turquoise
ZNF329	turquoise	turquoise	turquoise	turquoise
C4orf32	black	black	black	black
LYN	black	black	gray	gray
NRXN3	turquoise	turquoise	turquoise	turquoise
EXOC6B	turquoise	gray	turquoise	turquoise
LOXL1-AS1	turquoise	gray	gray	turquoise
WASF3	turquoise	turquoise	gray	turquoise
DMD	turquoise	turquoise	gray	turquoise
SAR1A	turquoise	gray	gray	turquoise
TGFBR3	turquoise	turquoise	gray	turquoise
MUM1	turquoise	gray	gray	turquoise
SESTD1	turquoise	gray	gray	turquoise
ODAM	turquoise	turquoise	turquoise	turquoise
OR51E1	turquoise	turquoise	turquoise	turquoise
TSHZ2	turquoise	turquoise	gray	turquoise
P2RX5	black	black	black	black
TMC8	black	black	black	black
DPP7	turquoise	gray	gray	gray
SPIRE1	turquoise	gray	turquoise	turquoise
ERO1LB	black	black	black	black
PAX5	black	black	black	black
LAMC2	turquoise	turquoise	turquoise	turquoise
LYZ	black	black	black	black
FOSL2	black	gray	gray	gray
NEFL	turquoise	turquoise	turquoise	turquoise
ALKBH5	black	gray	black	gray
MKX	turquoise	turquoise	turquoise	turquoise
SLC16A3	black	gray	black	black
AFAP1L2	black	magenta	black	black
PPP1R3B	turquoise	gray	turquoise	turquoise
CYP2U1	turquoise	turquoise	turquoise	turquoise
LPAR6	turquoise	turquoise	turquoise	turquoise
FAM107B	black	black	black	black
KRT6A	turquoise	turquoise	turquoise	turquoise
FGF13	turquoise	turquoise	gray	turquoise
SCEL	turquoise	turquoise	turquoise	turquoise
DST	turquoise	gray	turquoise	turquoise
SALL4	turquoise	turquoise	gray	turquoise
TGFBR2	turquoise	gray	gray	turquoise
SST	turquoise	gray	turquoise	turquoise
FNDC3B	turquoise	gray	turquoise	turquoise
TUBB2B	turquoise	turquoise	turquoise	turquoise
ZMAT3	turquoise	turquoise	gray	turquoise
SERPINA3	turquoise	gray	turquoise	turquoise
FLCN	black	gray	black	black
PFN2	turquoise	turquoise	turquoise	turquoise
SLCO3A1	turquoise	turquoise	turquoise	turquoise
AHR	black	magenta	gray	gray
COL27A1	turquoise	gray	turquoise	turquoise
SERTAD4	turquoise	turquoise	turquoise	turquoise
ANPEP	black	black	black	black
SOCS1	black	black	black	black
F5	black	black	gray	gray
SLC16A10	turquoise	gray	gray	turquoise
AIF1L	black	black	black	gray
GABBR1	turquoise	gray	gray	turquoise
FGD6	black	black	black	gray
ADM	black	black	black	black
ARRDC3	turquoise	turquoise	turquoise	turquoise
RHOD	turquoise	turquoise	turquoise	turquoise
IL1B	black	black	black	black
PROK2	black	black	black	black
CXCL5	turquoise	gray	gray	turquoise
IL24	turquoise	gray	turquoise	turquoise
FFAR2	black	black	black	black
CDKN2A	turquoise	turquoise	turquoise	turquoise
LAIR2	black	black	black	black
IRF5	turquoise	gray	turquoise	turquoise
HSPA12A	turquoise	turquoise	turquoise	turquoise
LDLRAD4	turquoise	gray	gray	turquoise
CXCL6	turquoise	gray	turquoise	gray
SLC22A4	turquoise	gray	turquoise	turquoise
PROS1	turquoise	turquoise	turquoise	turquoise
ARHGAP6	turquoise	turquoise	turquoise	turquoise
TYRP1	turquoise	gray	turquoise	turquoise
PYGL	black	black	black	black
PDE3A	turquoise	turquoise	gray	turquoise
BNIP3	turquoise	turquoise	turquoise	turquoise
CDC42BPA	turquoise	turquoise	turquoise	turquoise
RAB30	turquoise	turquoise	turquoise	turquoise
NOTCH2NL	turquoise	turquoise	turquoise	turquoise
LTF	black	gray	gray	black
11-Sep	turquoise	gray	gray	turquoise
EVA1A	turquoise	turquoise	gray	turquoise
TM4SF1	turquoise	gray	turquoise	turquoise
MRPS21	black	black	black	black
WWC3	turquoise	turquoise	gray	turquoise
LPL	turquoise	turquoise	turquoise	turquoise
SLC16A4	turquoise	turquoise	turquoise	turquoise
KLF7	turquoise	turquoise	gray	turquoise
MICB	black	magenta	black	black
PDK4	turquoise	turquoise	turquoise	turquoise
IGF2	turquoise	turquoise	turquoise	turquoise
ADA	black	black	black	black
PARP8	black	black	black	black
FAM127B	turquoise	gray	gray	turquoise
UCP2	black	black	black	black
FAM120C	turquoise	turquoise	gray	turquoise
C3orf14	turquoise	turquoise	turquoise	turquoise
RHOBTB1	turquoise	turquoise	turquoise	turquoise
SACS	turquoise	gray	gray	turquoise
GNA15	black	black	black	black
SCG5	turquoise	gray	turquoise	turquoise
MAGED1	turquoise	turquoise	gray	turquoise
SOCS2	turquoise	gray	gray	turquoise
TLR4	turquoise	gray	turquoise	turquoise
FKBP5	black	gray	black	gray
SAMD3	black	black	black	black
IGHG1	black	black	black	black
FAM46C	black	black	black	black
ANKRD36BP2	black	black	black	black
KLRB1	black	black	black	black
IGJ	black	black	black	black
FCRL5	black	black	black	black
CD79A	black	black	black	black
PNOC	black	black	gray	black
IGHM	black	black	black	black
IGKC	black	black	black	black
DERL3	black	black	black	black
TNFRSF17	black	black	black	black
POU2AF1	black	black	black	black
GUSBP11	black	black	black	black
IGLL3P	black	black	black	black
MZB1	black	black	black	black
PTK7	turquoise	gray	turquoise	turquoise
MAP3K6	black	magenta	black	gray
PPFIBP1	black	gray	gray	gray
COL4A4	turquoise	turquoise	turquoise	turquoise
DUSP3	turquoise	gray	gray	turquoise
CP	black	black	black	gray
CERK	turquoise	turquoise	gray	turquoise
SMOC2	turquoise	turquoise	turquoise	turquoise
RARRES1	black	black	black	black
SAV1	black	black	black	gray
MT1M	black	black	black	black
MT1E	black	black	black	black
MT2A	black	black	black	black
MT1F	black	black	black	black
MT1H	black	black	black	black
MT1G	black	black	black	black
MT1X	black	black	black	black
SLC2A10	turquoise	turquoise	turquoise	turquoise
STMN3	turquoise	gray	turquoise	turquoise
SGCB	turquoise	gray	gray	turquoise
SERPINI1	turquoise	turquoise	turquoise	turquoise
RARA	turquoise	gray	gray	turquoise
CIRBP	turquoise	gray	gray	turquoise
EVC	turquoise	turquoise	turquoise	turquoise
GNAI1	turquoise	turquoise	turquoise	turquoise
PLA2G16	turquoise	turquoise	gray	turquoise
PTGS2	turquoise	gray	turquoise	turquoise
CXCL16	black	black	black	black
LEPREL4	turquoise	gray	turquoise	turquoise
KIT	turquoise	gray	gray	turquoise
SMIM3	turquoise	turquoise	gray	turquoise
TMEM173	black	black	gray	gray
SLC9B2	turquoise	gray	gray	turquoise
ST20	black	gray	gray	black
BMPR1B	turquoise	turquoise	turquoise	turquoise
KCTD1	black	black	black	gray
ZFP37	turquoise	turquoise	gray	turquoise
B2M	black	black	black	gray
PNMA2	black	black	black	gray
MMP12	black	black	black	black
NOV	turquoise	turquoise	turquoise	turquoise
CHFR	turquoise	gray	turquoise	turquoise
SLFN5	turquoise	gray	gray	gray
CCDC109B	black	magenta	black	black
BCL2	black	black	black	black
BTN3A2	black	black	black	black
IL32	black	black	black	gray
STK17B	black	black	black	black
FAS	black	magenta	black	black
IL15	black	black	black	black
BIRC3	black	black	black	black
STK17A	black	black	black	black
JAK2	black	black	black	black
TNFAIP8	black	black	black	black
FBXO6	black	black	black	black
EPSTI1	black	black	black	black
RNF213	black	gray	black	black
BATF2	black	black	black	gray
PSMB10	black	gray	black	black
ISG20	black	black	black	black
IFI27	black	black	black	black
OASL	black	black	black	black
SECTM1	black	black	black	black
HLA-F	black	black	black	black
IFIT5	black	black	black	black
IFI6	black	black	black	black
ETV7	black	black	black	gray
APOL6	black	black	black	black
RTP4	black	black	black	black
DDX60	black	black	black	black
SAMD9	black	black	black	black
AIM2	black	black	black	black
TAP2	black	black	black	black
LAMP3	black	black	black	black
CXCL11	black	black	black	black
NLRC5	black	black	black	black
ODF3B	black	black	black	black
TRIM69	black	black	black	black
IRF7	black	black	black	black
IFIH1	black	black	black	black
MX2	black	black	black	black
OAS3	black	black	black	black
IFI35	black	black	black	black
USP18	black	black	black	black
HERC6	black	black	black	black
ISG15	black	black	black	black
PARP14	black	black	black	black
PARP9	black	black	black	black
SAMD9L	black	black	black	black
XAF1	black	black	black	black
IFIT1	black	black	gray	gray
IFIT2	black	black	black	black
RSAD2	black	black	black	black
IFI44	black	black	black	black
CMPK2	black	black	black	black
OAS2	black	black	black	black
IFI44L	black	black	black	black
IFIT3	black	black	black	black
MX1	black	black	black	black
IRF9	black	black	black	black
LAP3	black	black	black	black
WARS	black	black	black	black
IRF1	black	black	black	black
PSMB9	black	black	black	black
TAP1	black	black	black	black
STAT1	black	black	black	black
UBE2L6	black	black	black	black
PKIA	turquoise	turquoise	turquoise	turquoise
SLCO2A1	turquoise	gray	turquoise	turquoise
MAST4	turquoise	turquoise	turquoise	turquoise
CGNL1	turquoise	turquoise	turquoise	turquoise
SLC7A2	turquoise	turquoise	turquoise	turquoise
SERPINB2	black	black	gray	gray
CTLA4	black	black	black	black
MAFF	turquoise	gray	gray	turquoise
PDGFD	turquoise	turquoise	turquoise	turquoise
TUBB2A	black	black	black	gray
EPHA7	turquoise	turquoise	turquoise	turquoise
GHR	turquoise	turquoise	turquoise	turquoise
PCDH18	turquoise	gray	turquoise	turquoise
FOXF2	turquoise	gray	turquoise	turquoise
NKX2-3	turquoise	gray	turquoise	turquoise
SYNGR3	black	black	black	gray
TRERF1	black	black	black	gray
S100A13	turquoise	gray	turquoise	turquoise
LIMCH1	turquoise	turquoise	turquoise	turquoise
BNIP3L	black	black	black	gray
EVA1C	turquoise	turquoise	gray	turquoise
LAMA5	turquoise	turquoise	turquoise	turquoise
EDNRB	turquoise	gray	turquoise	turquoise
BANK1	black	black	black	black
ZNF300	turquoise	turquoise	turquoise	turquoise
HOXD4	turquoise	turquoise	gray	turquoise
CST1	turquoise	turquoise	turquoise	turquoise
CST4	turquoise	turquoise	turquoise	turquoise
FOXP2	turquoise	turquoise	gray	turquoise
ZNF134	turquoise	turquoise	turquoise	turquoise
ARNT2	turquoise	gray	gray	turquoise
MUM1L1	turquoise	turquoise	turquoise	turquoise
SCRN1	turquoise	turquoise	turquoise	turquoise
ZNF880	turquoise	turquoise	turquoise	turquoise
NINL	turquoise	gray	gray	turquoise
PCNX	turquoise	gray	gray	turquoise
ARHGAP28	turquoise	turquoise	turquoise	turquoise
TP53INP2	turquoise	gray	turquoise	turquoise
CFD	black	black	black	black
SNX20	black	black	black	black
ERRFI1	turquoise	gray	gray	turquoise
MEGF6	turquoise	turquoise	gray	turquoise
RAI2	turquoise	turquoise	turquoise	turquoise
FAXC	turquoise	turquoise	turquoise	turquoise
CASP4	black	black	black	black
LCK	black	black	black	black
NCALD	turquoise	gray	turquoise	turquoise
CR2	black	black	gray	black
MS4A1	black	black	black	black
BAG3	turquoise	gray	gray	turquoise
FMO3	turquoise	gray	turquoise	turquoise
SLC16A7	turquoise	turquoise	gray	turquoise
TXNIP	turquoise	turquoise	gray	turquoise
LXN	black	gray	black	black
ACSL1	turquoise	gray	turquoise	turquoise
GLUL	black	black	black	black
HSPA2	turquoise	turquoise	turquoise	turquoise
EGFL6	turquoise	gray	turquoise	gray
TEAD2	turquoise	gray	turquoise	turquoise
TLE4	turquoise	turquoise	turquoise	turquoise
CC2D2A	turquoise	turquoise	turquoise	turquoise
ELL2	black	black	black	black
PIK3R5	black	black	black	gray
DUSP10	turquoise	gray	gray	turquoise
ANO1	turquoise	gray	gray	turquoise
KCNS3	turquoise	turquoise	gray	turquoise
PCDHB2	turquoise	turquoise	turquoise	turquoise
HOXC6	black	black	black	black
LRMP	black	black	black	black
FTH1	black	gray	gray	gray
SPATS2L	black	gray	black	gray
ZFP82	turquoise	turquoise	turquoise	turquoise
FBN2	turquoise	turquoise	turquoise	turquoise
PDZD2	turquoise	gray	turquoise	turquoise
TMEM200A	turquoise	turquoise	turquoise	turquoise
L1CAM	turquoise	turquoise	gray	turquoise
BHLHE40	turquoise	gray	turquoise	turquoise
CAPG	black	black	black	black
ULK2	turquoise	turquoise	turquoise	turquoise
PDLIM5	turquoise	turquoise	gray	turquoise
RBM24	turquoise	turquoise	turquoise	turquoise
RAB3B	turquoise	gray	turquoise	turquoise
UBASH3B	black	black	black	black
SNX24	turquoise	gray	gray	gray
GAS2L1	black	black	black	gray
HOTAIRM1	turquoise	turquoise	turquoise	turquoise
CPE	turquoise	turquoise	gray	turquoise
LY6E	black	black	black	black
FKBP1A	turquoise	gray	turquoise	turquoise
CD1D	black	black	black	gray
ST6GAL2	turquoise	turquoise	gray	turquoise
PTPN21	turquoise	turquoise	turquoise	turquoise
NGFRAP1	turquoise	turquoise	turquoise	turquoise
RIN2	turquoise	gray	turquoise	turquoise
FPR2	black	black	black	black
INHBB	turquoise	turquoise	turquoise	turquoise
LYST	turquoise	turquoise	gray	turquoise
APOL1	black	black	black	black
FOXC1	turquoise	turquoise	turquoise	turquoise
EGR1	turquoise	turquoise	turquoise	turquoise
TFPI2	turquoise	turquoise	turquoise	turquoise
IGFL2	turquoise	turquoise	turquoise	turquoise
CDH19	turquoise	turquoise	turquoise	turquoise
ZKSCAN7	turquoise	turquoise	turquoise	turquoise
RAB38	black	black	black	gray
GAP43	turquoise	turquoise	turquoise	turquoise
CFI	turquoise	turquoise	turquoise	turquoise
AOX1	turquoise	turquoise	turquoise	turquoise
HAS2	turquoise	gray	turquoise	turquoise
GAS6	turquoise	turquoise	turquoise	turquoise
PPM1K	black	black	black	black
IL1RAP	turquoise	gray	turquoise	turquoise
PLOD2	turquoise	turquoise	turquoise	turquoise
OGFRL1	black	black	black	black
TRIL	turquoise	turquoise	turquoise	turquoise
GRB10	turquoise	turquoise	turquoise	turquoise
ASPA	turquoise	turquoise	turquoise	turquoise
WNT5A	turquoise	turquoise	turquoise	turquoise
PCDHB16	turquoise	turquoise	turquoise	turquoise
C9orf3	turquoise	gray	turquoise	turquoise
CARD6	black	gray	gray	gray
FCER1A	turquoise	turquoise	turquoise	turquoise
CTSC	black	black	black	black
GREM2	turquoise	gray	turquoise	turquoise
KCTD15	turquoise	turquoise	gray	turquoise
OSBPL1A	turquoise	turquoise	gray	turquoise
CX3CL1	black	black	black	black
MARCKS	turquoise	gray	gray	turquoise
HES4	turquoise	gray	gray	turquoise
IKZF1	black	black	black	black
GAA	turquoise	gray	gray	turquoise
FBXL2	turquoise	turquoise	turquoise	turquoise
MCL1	turquoise	gray	gray	turquoise
MR1	black	gray	black	black
TMEM163	turquoise	turquoise	turquoise	gray
CXCR2	black	black	black	black
TLR7	black	gray	gray	black
GLIS3	turquoise	turquoise	turquoise	turquoise
FOSB	turquoise	gray	turquoise	turquoise
MAP3K8	black	black	black	black
FAM43A	turquoise	gray	gray	turquoise
RHOB	turquoise	gray	gray	turquoise
CST2	turquoise	turquoise	turquoise	turquoise
CPM	black	gray	black	gray
WASF1	turquoise	gray	gray	turquoise
CPNE8	turquoise	turquoise	turquoise	turquoise
FAIM3	black	black	black	black
CLC	black	black	gray	black
GRK5	turquoise	turquoise	turquoise	turquoise
FDCSP	black	black	gray	black
SOAT1	turquoise	gray	turquoise	turquoise
ENO2	turquoise	gray	gray	turquoise
MAGI2	turquoise	turquoise	turquoise	turquoise
SDC3	turquoise	gray	gray	turquoise
MIAT	black	black	black	black
ADAM28	black	black	black	black
SLC11A1	black	black	gray	gray
FZD7	turquoise	turquoise	turquoise	turquoise
RGS5	turquoise	gray	turquoise	turquoise
CNN3	turquoise	gray	gray	turquoise
MAX	black	gray	black	black
S100A12	black	black	black	black
PTPLA	turquoise	gray	turquoise	turquoise
SLC2A5	black	black	black	black
RNASE1	black	black	black	gray
ANGPT2	turquoise	gray	turquoise	turquoise
KLF12	turquoise	turquoise	turquoise	turquoise
NLGN4X	turquoise	turquoise	turquoise	turquoise
ZNF618	turquoise	gray	gray	turquoise
HERC5	black	gray	gray	gray
DAB2	turquoise	turquoise	gray	turquoise
PLK2	turquoise	gray	gray	turquoise
NUPR1	turquoise	turquoise	gray	turquoise
F8	turquoise	turquoise	turquoise	turquoise
LEPR	turquoise	turquoise	turquoise	turquoise
SERPINB9	black	black	gray	black
DYNC2H1	turquoise	turquoise	turquoise	turquoise
RNF217	turquoise	turquoise	turquoise	turquoise
GNAL	turquoise	turquoise	turquoise	turquoise
PELO	turquoise	turquoise	gray	gray
C16orf54	black	black	black	black
STMN2	turquoise	turquoise	turquoise	turquoise
CEBPD	black	black	black	black
MERTK	black	gray	gray	gray
HLA-DQA1	black	black	black	black
ETV5	turquoise	gray	gray	turquoise
B3GALNT1	turquoise	turquoise	turquoise	turquoise
CH25H	turquoise	gray	turquoise	turquoise
ETV1	turquoise	turquoise	gray	turquoise
PCOLCE2	turquoise	turquoise	turquoise	turquoise
FAM114A1	turquoise	gray	gray	turquoise
RILPL2	black	black	black	black
TMEM35	turquoise	turquoise	turquoise	turquoise
PHACTR1	black	black	black	black
SLC20A1	turquoise	gray	gray	turquoise
RAB12	black	black	black	gray
TMOD2	turquoise	turquoise	turquoise	turquoise
UGCG	turquoise	gray	gray	turquoise
ATL1	turquoise	turquoise	gray	turquoise
OPTN	black	gray	black	black
C16orf62	turquoise	gray	turquoise	turquoise
KCND3	turquoise	gray	turquoise	turquoise
SNX10	black	black	black	black
HOXD8	turquoise	turquoise	gray	turquoise
HHEX	black	black	black	gray
LDB3	turquoise	turquoise	turquoise	turquoise
APBB2	turquoise	gray	gray	turquoise
ADAMTS9	turquoise	turquoise	turquoise	turquoise
LMO4	black	black	black	black
GJB2	turquoise	turquoise	gray	turquoise
MYOF	turquoise	turquoise	gray	turquoise
CR1	black	black	gray	black
SORBS1	turquoise	turquoise	gray	turquoise
CTSZ	black	black	gray	gray
RPS6KA2	turquoise	turquoise	gray	turquoise
PRKAR2B	black	black	gray	black
PLEKHH2	turquoise	turquoise	turquoise	turquoise
FKBP14	turquoise	turquoise	turquoise	turquoise
NFKBIA	black	black	black	black
ACSS3	turquoise	turquoise	turquoise	turquoise
TOX2	black	black	black	black
S100A9	black	black	black	black
ATL3	turquoise	gray	gray	turquoise
TPBG	turquoise	gray	gray	turquoise
LAMB1	turquoise	turquoise	turquoise	turquoise
SCUBE3	turquoise	turquoise	gray	turquoise
IRS1	turquoise	turquoise	turquoise	turquoise
ST3GAL1	turquoise	gray	turquoise	turquoise
TGM2	black	black	black	gray
NBEA	turquoise	turquoise	turquoise	turquoise
LRP12	turquoise	turquoise	turquoise	turquoise
COL21A1	turquoise	turquoise	turquoise	turquoise
HDAC9	turquoise	turquoise	turquoise	turquoise
PER3	turquoise	turquoise	gray	turquoise
ADIPOQ	turquoise	turquoise	turquoise	turquoise
EGR3	turquoise	gray	turquoise	turquoise
UST	turquoise	turquoise	gray	turquoise
RNF144B	black	black	black	black
ENPEP	turquoise	turquoise	turquoise	turquoise
SLC16A6	black	black	black	black
S100B	black	black	black	gray
BHLHE41	turquoise	turquoise	turquoise	turquoise
COTL1	black	black	black	black
PDE4B	black	black	black	black
IL1RN	black	black	black	black
OSM	black	black	black	black
PDGFA	turquoise	turquoise	turquoise	turquoise
CEP85L	black	gray	black	gray
ID4	turquoise	turquoise	turquoise	turquoise
BAG2	turquoise	turquoise	gray	turquoise
TWSG1	turquoise	gray	turquoise	turquoise
CHL1	turquoise	turquoise	turquoise	turquoise
CD200	turquoise	turquoise	gray	turquoise
RIMKLB	turquoise	turquoise	turquoise	turquoise
ALOX5	black	black	black	black
ZNF304	turquoise	turquoise	turquoise	turquoise
PODXL	turquoise	turquoise	gray	turquoise
PFKFB3	turquoise	gray	gray	gray
P2RY14	black	black	gray	gray
DCBLD2	turquoise	turquoise	turquoise	turquoise
CSTA	black	black	gray	black
ANTXR2	turquoise	turquoise	gray	turquoise
PLTP	turquoise	gray	turquoise	turquoise
ZFP36L1	turquoise	turquoise	turquoise	turquoise
GNS	turquoise	gray	gray	turquoise
TGFBR1	turquoise	turquoise	turquoise	turquoise
DUSP5	black	gray	gray	gray
DPYSL2	turquoise	turquoise	turquoise	turquoise
CORIN	turquoise	turquoise	gray	turquoise
LSAMP	turquoise	turquoise	turquoise	turquoise
MMRN1	turquoise	turquoise	turquoise	turquoise
RCAN1	turquoise	turquoise	turquoise	turquoise
ADH1B	turquoise	turquoise	turquoise	turquoise
ABCA8	turquoise	turquoise	turquoise	turquoise
TMEM100	turquoise	turquoise	turquoise	turquoise
HSPB6	turquoise	turquoise	turquoise	turquoise
MYOCD	turquoise	gray	turquoise	turquoise
DAPK1	black	gray	black	gray
RIT1	black	gray	black	black
AMIGO2	turquoise	turquoise	gray	turquoise
CPED1	turquoise	gray	turquoise	turquoise
ACTB	turquoise	gray	gray	turquoise
CLIC6	turquoise	turquoise	turquoise	turquoise
MAOB	turquoise	turquoise	turquoise	turquoise
FAT4	turquoise	gray	turquoise	turquoise
TDO2	black	gray	gray	black
FOXO1	turquoise	turquoise	turquoise	turquoise
TM4SF18	turquoise	turquoise	turquoise	turquoise
FMOD	turquoise	turquoise	turquoise	turquoise
PDE5A	turquoise	turquoise	turquoise	turquoise
ITIH5	turquoise	gray	turquoise	turquoise
LPP	turquoise	turquoise	gray	turquoise
VIP	turquoise	turquoise	turquoise	turquoise
TMEM158	turquoise	turquoise	turquoise	turquoise
RAB23	turquoise	turquoise	turquoise	turquoise
ARHGAP29	turquoise	turquoise	turquoise	turquoise
BLVRA	black	black	black	black
ZBTB20	turquoise	gray	gray	turquoise
CCL11	turquoise	gray	turquoise	turquoise
PLAUR	black	black	black	black
RAMP1	turquoise	turquoise	gray	turquoise
PCED1B	turquoise	gray	gray	turquoise
CDKN2B	turquoise	turquoise	turquoise	turquoise
NR2F2	turquoise	gray	turquoise	turquoise
NFIC	turquoise	gray	gray	turquoise
FGF2	turquoise	turquoise	turquoise	turquoise
SSBP2	turquoise	turquoise	turquoise	turquoise
LPAR1	turquoise	turquoise	turquoise	turquoise
FSCN1	turquoise	turquoise	gray	turquoise
TNFAIP3	black	black	black	black
KCNJ15	turquoise	gray	gray	gray
CSGALNACT1	turquoise	turquoise	turquoise	turquoise
ADCY7	black	black	black	gray
PTX3	turquoise	gray	turquoise	turquoise
CX3CR1	turquoise	turquoise	turquoise	turquoise
SOBP	turquoise	turquoise	turquoise	turquoise
PDZRN3	turquoise	turquoise	turquoise	turquoise
PKIG	turquoise	gray	turquoise	turquoise
EMP1	turquoise	turquoise	turquoise	turquoise
LIFR	turquoise	turquoise	turquoise	turquoise
LEF1	turquoise	turquoise	turquoise	turquoise
TLN1	turquoise	gray	gray	turquoise
SPON1	turquoise	turquoise	turquoise	turquoise
HPGDS	turquoise	turquoise	gray	turquoise
GSN	turquoise	gray	turquoise	turquoise
IL6	turquoise	gray	turquoise	turquoise
CITED2	black	gray	black	gray
PRDM1	black	black	black	black
TANC2	turquoise	turquoise	gray	turquoise
IL6ST	turquoise	turquoise	turquoise	turquoise
ANXA1	black	gray	black	gray
G0S2	black	black	gray	black
GPRC5B	turquoise	turquoise	turquoise	turquoise
ROR1	turquoise	turquoise	gray	turquoise
TRIM6	turquoise	turquoise	turquoise	turquoise
GLIPR1	turquoise	turquoise	turquoise	turquoise
CTSO	turquoise	turquoise	gray	turquoise
RGCC	turquoise	turquoise	turquoise	turquoise
STC1	turquoise	turquoise	turquoise	turquoise
HECTD2	turquoise	turquoise	turquoise	turquoise
RASA3	turquoise	turquoise	turquoise	turquoise
MCTP1	turquoise	turquoise	gray	turquoise
NRP2	turquoise	turquoise	gray	turquoise
CMAHP	turquoise	turquoise	turquoise	turquoise
CPA3	turquoise	turquoise	turquoise	turquoise
MAP4K4	turquoise	turquoise	turquoise	turquoise
IRAK3	black	gray	black	gray
PLA1A	turquoise	gray	turquoise	turquoise
FAM63B	turquoise	turquoise	gray	turquoise
TRIB2	black	black	black	black
KLF9	turquoise	turquoise	gray	turquoise
PRNP	turquoise	turquoise	turquoise	turquoise
ALDH1L2	turquoise	turquoise	turquoise	turquoise
CALB2	turquoise	turquoise	turquoise	turquoise
CCDC102B	turquoise	turquoise	turquoise	turquoise
ELMO1	turquoise	gray	gray	gray
TPP1	turquoise	gray	turquoise	turquoise
TPSAB1	turquoise	gray	turquoise	turquoise
CD36	black	gray	gray	gray
RRAGD	turquoise	turquoise	gray	turquoise
ADAM8	black	black	black	black
FZD2	turquoise	turquoise	gray	turquoise
PTGDS	turquoise	turquoise	turquoise	turquoise
ABI3BP	turquoise	turquoise	turquoise	turquoise
SLC43A3	turquoise	gray	gray	gray
GNB4	black	gray	black	black
IKBIP	black	black	black	gray
CHI3L1	turquoise	turquoise	turquoise	gray
SOD2	black	black	black	black	black
TYMP	black	black	black	black	black
BST2	black	black	black	black	black
CCL19	black	black	black	black	black
FCRL3	black	black	black	black	black
CD80	black	black	black	black	black
VNN2	black	black	black	black	black
FMO1	black	gray	gray	gray	black
LGMN	black	black	black	black	black
ZBED2	black	black	black	black	black
PIK3AP1	black	black	black	black	black
SLFN12	black	gray	black	gray	black
LAX1	black	black	black	black	black
GNLY	black	black	black	black	black
TNFAIP2	black	black	black	black	black
SH2D1A	black	black	black	black	black
IL18RAP	black	black	black	black	black
IFI16	black	black	black	black	black
EPB41L3	black	black	black	gray	black
RAB8B	black	gray	black	black	black
RUNX3	black	black	black	black	black
HS3ST3B1	black	black	black	black	black
SP110	black	black	black	black	black
IL7R	black	black	black	black	black
NCF4	black	black	black	black	black
RGS1	black	black	black	black	black
ITM2A	black	black	black	black	black
AQP9	black	black	black	black	black
CLEC5A	black	black	gray	gray	black
TREM1	black	black	black	black	black
SCPEP1	black	black	black	black	black
NPC2	black	gray	black	black	black
LRRK2	black	black	gray	black	black
ITGA4	black	black	gray	black	black
KYNU	black	black	black	black	black
HLA-DOB	black	black	black	black	black
SDS	black	black	black	black	black
CSF3R	black	black	black	black	black
TIAM1	black	black	black	gray	black
S100A8	black	black	black	black	black
FCN1	black	black	gray	black	black
RARRES3	black	black	black	black	black
CCR7	black	black	black	black	black
STAT2	black	gray	black	black	black
NFATC1	black	gray	black	gray	black
HMOX1	black	black	black	black	black
IDO1	black	black	black	black	black
THEMIS	black	black	black	black	black
PRF1	black	black	black	black	black
NPL	black	black	black	black	black
TRAT1	black	black	black	black	black
CPVL	black	black	gray	black	black
CCL13	black	black	black	black	black
SAMHD1	black	black	black	black	black
MMP9	black	black	black	black	black
TRIM22	black	black	black	black	black
BTN3A3	black	black	black	black	black
PLCG2	black	black	black	black	black
CST7	black	black	black	black	black
SLC7A7	black	black	black	black	black
STX11	black	black	black	black	black
NAPSB	black	black	black	gray	black
ANKRD44	black	black	black	black	black
FGL2	black	black	black	black	black
RGS18	black	black	black	black	black
CD40	black	black	black	black	black
GPR84	black	black	black	black	black
FAM65B	black	black	black	black	black
CXCL10	black	black	black	black	black
GBP2	black	black	black	black	black
ITGB2-AS1	black	black	black	black	black
HSD11B1	black	black	black	gray	black
ADORA3	black	black	black	black	black
CYTIP	black	black	black	black	black
ENPP2	black	black	black	black	black
ATP8B4	black	black	black	black	black
GZMA	black	black	black	black	black
EOMES	black	black	black	black	black
GBP4	black	black	black	black	black
CD69	black	black	black	black	black
CXCR4	black	black	black	black	black
GPR34	black	gray	black	black	black
ARHGDIB	black	black	black	black	black
GBP1	black	black	black	black	black
CD38	black	black	black	black	black
BCL2A1	black	black	black	black	black
JAK3	black	black	black	black	black
CORO1A	black	black	black	black	black
CD274	black	black	black	black	black
RASGRP1	black	black	black	black	black
GATA3	black	black	black	black	black
APOL3	black	black	black	black	black
PLEK	black	black	black	black	black
EMR2	black	black	black	black	black
CD27	black	black	black	black	black
RASSF4	black	black	black	black	black
PPP1R16B	black	black	black	black	black
SIGLEC1	black	black	black	black	black
GNG2	black	black	black	gray	black
GPR183	black	black	black	black	black
CYSLTR1	black	black	black	black	black
GLIPR2	black	black	black	gray	black
DOCK8	black	black	black	black	black
RNASE6	black	black	black	black	black
APOE	black	black	black	black	black
ITGAX	black	black	black	black	black
RAC2	black	black	black	black	black
GM2A	black	gray	black	black	black
TREM2	black	black	black	gray	black
CXCL13	black	black	black	black	black
CCL8	black	black	black	black	black
CXCL9	black	black	black	black	black
GGTA1P	black	black	black	black	black
NLRC3	black	black	black	black	black
FPR1	black	black	black	black	black
APOC1	black	black	black	black	black
GPR171	black	black	black	black	black
GIMAP7	black	black	black	black	black
RHOH	black	black	black	black	black
ICAM1	black	black	black	black	black
VAMP5	black	black	black	black	black
KLRD1	black	black	black	black	black
TMEM140	black	black	black	black	black
TLR2	black	black	black	black	black
CLEC4E	black	black	black	black	black
SLC1A3	black	black	black	black	black
CLIC2	black	black	black	black	black
CCR2	black	black	black	black	black
ITGAL	black	black	black	black	black
GZMH	black	black	black	black	black
IL4I1	black	black	black	black	black
SUCNR1	black	black	black	black	black
SELL	black	black	black	black	black
IL2RA	black	black	black	black	black
CCL18	black	black	black	black	black
ITK	black	black	black	black	black
NKG7	black	black	black	black	black
CECR1	black	black	black	black	black
CD8A	black	black	black	black	black
ST8SIA4	black	black	black	black	black
CCL4	black	black	black	black	black
APOBEC3G	black	black	black	black	black
EVL	black	black	black	black	black
IL18BP	black	black	black	black	black
PIK3CG	black	black	black	black	black
FCGR3B	black	black	black	black	black
C5AR1	black	black	black	black	black
FCGR2C	black	black	black	black	black
ALOX5AP	black	black	black	black	black
ARL4C	black	gray	gray	gray	black
VCAM1	black	black	gray	gray	black
MSR1	black	black	black	black	black
TM6SF1	black	black	black	black	black
DSE	black	gray	gray	black	black
NR3C1	black	black	gray	gray	black
MRC1	black	black	black	black	black
NRP1	black	gray	black	gray	black
ZEB2	black	gray	gray	gray	black
FGR	black	black	black	black	black
KMO	black	black	black	black	black
DOK3	black	black	black	black	black
DPYD	black	black	black	black	black
CLEC4A	black	black	black	black	black
CLEC2B	black	black	black	black	black
SLAMF7	black	black	black	black	black
HLA-DMA	black	black	black	black	black
SLC15A3	black	black	black	black	black
PIK3CD	black	black	black	black	black
KLHL6	black	black	black	black	black
SAMSN1	black	black	black	black	black
TRAF3IP3	black	black	black	black	black
CCL5	black	black	black	black	black
ARHGAP15	black	black	black	black	black
CD72	black	black	black	black	black
IL2RB	black	black	black	black	black
MS4A7	black	black	black	black	black
1-Mar	black	black	black	black	black
GBP5	black	black	black	black	black
CD74	black	black	black	black	black
FAM49A	black	black	black	black	black
PRKCB	black	black	black	black	black
FYB	black	black	black	black	black
GZMK	black	black	black	black	black
FAM26F	black	black	black	black	black
SLC31A2	black	black	black	black	black
P2RY13	black	black	black	black	black
GIMAP8	black	black	black	black	black
HLA-DOA	black	black	black	black	black
TLR1	black	black	black	black	black
PTPRC	black	black	black	black	black
LY86	black	black	black	black	black
LILRB2	black	black	black	black	black
DOCK10	black	black	black	black	black
SRGN	black	black	black	black	black
CD2	black	black	black	black	black
RASSF5	black	black	black	black	black
HLA-DQB1	black	black	black	black	black
GIMAP1	black	black	black	black	black
THEMIS2	black	black	black	black	black
ACP5	black	black	black	black	black
TFEC	black	black	black	black	black
FCGR2B	black	black	black	black	black
MPEG1	black	black	black	black	black
GPR65	black	black	black	black	black
HLA-DPA1	black	black	black	black	black
TNFSF13B	black	black	black	black	black
LILRB4	black	black	black	black	black
VSIG4	black	black	black	black	black
FCGR2A	black	black	black	black	black
NCF2	black	black	black	black	black
ITGAM	black	black	black	black	black
CHST11	black	black	black	black	black
PILRA	black	black	black	black	black
PLXNC1	black	black	black	black	black
GIMAP6	black	black	black	black	black
RASSF2	black	black	black	black	black
CD52	black	black	black	black	black
TRAC	black	black	black	black	black
EVI2A	black	black	black	black	black
MYO1F	black	black	black	black	black
FLI1	black	black	black	gray	black
RCSD1	black	black	black	black	black
C10orf128	black	black	black	black	black
CCR5	black	black	black	black	black
CYBB	black	black	black	black	black
SIGLEC10	black	black	black	black	black
CSF2RB	black	black	black	black	black
ARHGEF6	black	black	black	gray	black
WIPF1	black	black	black	gray	black
CD37	black	black	black	black	black
PLA2G7	black	black	black	black	black
EVI2B	black	black	black	black	black
ARHGAP9	black	black	black	black	black
HAVCR2	black	black	black	black	black
IGSF6	black	black	black	black	black
HLA-DRA	black	black	black	black	black
GMFG	black	black	black	black	black
IL10RA	black	black	black	black	black
SASH3	black	black	black	black	black
LCP1	black	black	black	black	black
GIMAP4	black	black	black	black	black
LY96	black	black	black	black	black
MS4A6A	black	black	black	black	black
CD14	black	black	black	black	black
CCR1	black	black	black	black	black
LST1	black	black	black	black	black
CD300LF	black	black	black	black	black
CD163	black	black	black	black	black
GPNMB	black	black	black	black	black
TLR8	black	black	black	black	black
HLA-DMB	black	black	black	black	black
MS4A4A	black	black	black	black	black
CD84	black	black	black	black	black
NCKAP1L	black	black	black	black	black
APBB1IP	black	black	black	black	black
DOCK2	black	black	black	black	black
ARHGAP30	black	black	black	black	black
SLA	black	black	black	black	black
CD48	black	black	black	black	black
HCLS1	black	black	black	black	black
C1orf162	black	black	black	black	black
C1QC	black	black	black	black	black
CSF1R	black	black	black	black	black
CD300A	black	black	black	black	black
MAFB	black	black	black	black	black
FPR3	black	black	black	black	black
CLEC7A	black	black	black	black	black
CD86	black	black	black	black	black
HCK	black	black	black	black	black
C3AR1	black	black	black	black	black
SLAMF8	black	black	black	black	black
LAIR1	black	black	black	black	black
FCER1G	black	black	black	black	black
TYROBP	black	black	black	black	black
CD53	black	black	black	black	black
C1QB	black	black	black	black	black
LAPTM5	black	black	black	black	black
C1QA	black	black	black	black	black
ITGB2	black	black	black	black	black
LCP2	black	black	black	black	black
MNDA	black	black	black	black	black
LRP1	turquoise	turquoise	gray	turquoise	turquoise
FOXF1	turquoise	gray	turquoise	turquoise	turquoise
ECM1	turquoise	turquoise	turquoise	turquoise	turquoise
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HSPB1	turquoise	turquoise	turquoise	turquoise	turquoise
SELE	turquoise	turquoise	turquoise	turquoise	turquoise
ANGPT1	turquoise	turquoise	turquoise	turquoise	turquoise
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COL7A1	turquoise	gray	turquoise	turquoise	turquoise
OBSL1	turquoise	turquoise	turquoise	turquoise	turquoise
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CDKN1C	turquoise	turquoise	turquoise	turquoise	turquoise
FRY	turquoise	turquoise	turquoise	turquoise	turquoise
MAP9	turquoise	turquoise	turquoise	turquoise	turquoise
CD99	turquoise	turquoise	turquoise	turquoise	turquoise
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PAM	turquoise	turquoise	turquoise	turquoise	turquoise
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TBC1D9	turquoise	turquoise	turquoise	turquoise	turquoise
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GULP1	turquoise	turquoise	turquoise	turquoise	turquoise
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PPAP2A	turquoise	turquoise	turquoise	turquoise	turquoise
FZD8	turquoise	turquoise	turquoise	turquoise	turquoise
PLA2G5	turquoise	turquoise	turquoise	turquoise	turquoise
PTN	turquoise	turquoise	turquoise	turquoise	turquoise
PRKG1	turquoise	turquoise	gray	turquoise	turquoise
RTN1	turquoise	turquoise	gray	turquoise	turquoise
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SFRP1	turquoise	turquoise	turquoise	turquoise	turquoise
FILIP1	turquoise	turquoise	turquoise	turquoise	turquoise
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STEAP4	turquoise	turquoise	turquoise	turquoise	turquoise
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UNC5B	turquoise	turquoise	turquoise	turquoise	turquoise
RBPMS	turquoise	turquoise	gray	turquoise	turquoise
KCNMA1	turquoise	turquoise	turquoise	turquoise	turquoise
DUSP1	turquoise	gray	turquoise	turquoise	turquoise
BCHE	turquoise	turquoise	turquoise	turquoise	turquoise
PCSK5	turquoise	turquoise	turquoise	turquoise	turquoise
LINC00341	turquoise	turquoise	gray	turquoise	turquoise
ADAMTS6	turquoise	turquoise	turquoise	turquoise	turquoise
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CLU	turquoise	turquoise	turquoise	turquoise	turquoise
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ATP8B2	turquoise	turquoise	turquoise	gray	turquoise
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HOXB2	turquoise	turquoise	gray	turquoise	turquoise
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MARCO	turquoise	gray	gray	gray	turquoise
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GPR161	turquoise	turquoise	turquoise	turquoise	turquoise
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FAM13C	turquoise	turquoise	turquoise	turquoise	turquoise
TMTC1	turquoise	turquoise	turquoise	turquoise	turquoise
PPP1R12B	turquoise	turquoise	turquoise	turquoise	turquoise
PGM5-AS1	turquoise	gray	turquoise	turquoise	turquoise
OGN	turquoise	turquoise	turquoise	turquoise	turquoise
C2orf40	turquoise	turquoise	turquoise	turquoise	turquoise
ANGPTL1	turquoise	turquoise	turquoise	turquoise	turquoise
MAMDC2	turquoise	turquoise	turquoise	turquoise	turquoise
TCEAL2	turquoise	turquoise	turquoise	turquoise	turquoise
ATP1A2	turquoise	turquoise	turquoise	turquoise	turquoise
CHRDL1	turquoise	turquoise	turquoise	turquoise	turquoise
PDZRN4	turquoise	turquoise	turquoise	turquoise	turquoise
SCN7A	turquoise	turquoise	turquoise	turquoise	turquoise
FHL1	turquoise	turquoise	turquoise	turquoise	turquoise
ANK2	turquoise	turquoise	turquoise	turquoise	turquoise
LMO3	turquoise	turquoise	turquoise	turquoise	turquoise
C5orf46	turquoise	turquoise	turquoise	turquoise	turquoise
FAM171B	turquoise	turquoise	turquoise	turquoise	turquoise
SCUBE2	turquoise	turquoise	turquoise	turquoise	turquoise
GPR133	turquoise	turquoise	turquoise	turquoise	turquoise
RDX	turquoise	turquoise	turquoise	turquoise	turquoise
CD109	turquoise	turquoise	turquoise	turquoise	turquoise
ROBO1	turquoise	turquoise	turquoise	turquoise	turquoise
ADARB1	turquoise	turquoise	gray	turquoise	turquoise
AGTR1	turquoise	turquoise	turquoise	turquoise	turquoise
SETBP1	turquoise	turquoise	turquoise	turquoise	turquoise
LYVE1	turquoise	turquoise	turquoise	turquoise	turquoise
GPX8	turquoise	turquoise	turquoise	turquoise	turquoise
CBX6	turquoise	turquoise	gray	turquoise	turquoise
COL16A1	turquoise	turquoise	turquoise	turquoise	turquoise
MAN1C1	turquoise	turquoise	turquoise	turquoise	turquoise
GXYLT2	turquoise	turquoise	turquoise	turquoise	turquoise
SHISA2	turquoise	turquoise	turquoise	turquoise	turquoise
GPX3	turquoise	turquoise	turquoise	turquoise	turquoise
LAMA2	turquoise	turquoise	turquoise	turquoise	turquoise
ZNF331	turquoise	turquoise	turquoise	turquoise	turquoise
OLR1	turquoise	gray	turquoise	turquoise	turquoise
LTBP3	turquoise	turquoise	turquoise	turquoise	turquoise
GPC1	turquoise	turquoise	turquoise	turquoise	turquoise
AHNAK2	turquoise	turquoise	turquoise	turquoise	turquoise
SPP1	turquoise	turquoise	turquoise	turquoise	turquoise
CNTN4	turquoise	turquoise	turquoise	turquoise	turquoise
BEX4	turquoise	turquoise	turquoise	turquoise	turquoise
6-Sep	turquoise	gray	gray	turquoise	turquoise
RGL1	turquoise	turquoise	turquoise	turquoise	turquoise
MEG3	turquoise	turquoise	turquoise	turquoise	turquoise
FABP4	turquoise	turquoise	turquoise	turquoise	turquoise
EDIL3	turquoise	turquoise	turquoise	turquoise	turquoise
APOD	turquoise	turquoise	turquoise	turquoise	turquoise
SLC2A3	turquoise	gray	turquoise	turquoise	turquoise
EMCN	turquoise	turquoise	turquoise	turquoise	turquoise
PRR16	turquoise	turquoise	turquoise	turquoise	turquoise
SHANK3	turquoise	turquoise	gray	turquoise	turquoise
PLA2G4C	turquoise	turquoise	turquoise	turquoise	turquoise
CSGALNACT2	turquoise	turquoise	turquoise	turquoise	turquoise
FGF7	turquoise	turquoise	turquoise	turquoise	turquoise
TSC22D3	turquoise	gray	turquoise	turquoise	turquoise
SIRPA	turquoise	gray	turquoise	turquoise	turquoise
CHRDL2	turquoise	turquoise	turquoise	turquoise	turquoise
TSPAN2	turquoise	turquoise	turquoise	turquoise	turquoise
OMD	turquoise	turquoise	turquoise	turquoise	turquoise
LINC00312	turquoise	turquoise	turquoise	turquoise	turquoise
LRRC17	turquoise	turquoise	turquoise	turquoise	turquoise
NAV3	turquoise	turquoise	turquoise	turquoise	turquoise
PTGER3	turquoise	turquoise	turquoise	turquoise	turquoise
ROR2	turquoise	turquoise	turquoise	turquoise	turquoise
SPHK1	turquoise	gray	turquoise	turquoise	turquoise
ANKRD6	turquoise	turquoise	turquoise	turquoise	turquoise
SLFN11	turquoise	gray	gray	turquoise	turquoise
STAB1	turquoise	turquoise	gray	turquoise	turquoise
ALPK2	turquoise	turquoise	turquoise	turquoise	turquoise
PLAT	turquoise	gray	turquoise	turquoise	turquoise
SOX7	turquoise	turquoise	turquoise	turquoise	turquoise
PPP1R14A	turquoise	turquoise	turquoise	turquoise	turquoise
PLAU	turquoise	turquoise	turquoise	turquoise	turquoise
CSRP2	turquoise	turquoise	turquoise	turquoise	turquoise
GRP	turquoise	turquoise	turquoise	turquoise	turquoise
BHLHE22	turquoise	turquoise	turquoise	turquoise	turquoise
EPHA3	turquoise	turquoise	turquoise	turquoise	turquoise
DIO2	turquoise	turquoise	turquoise	turquoise	turquoise
SCG2	turquoise	turquoise	turquoise	turquoise	turquoise
RGS16	turquoise	turquoise	gray	turquoise	turquoise
ELN	turquoise	turquoise	turquoise	turquoise	turquoise
ELK3	turquoise	turquoise	turquoise	turquoise	turquoise
CAP2	turquoise	turquoise	gray	turquoise	turquoise
GPX7	turquoise	turquoise	turquoise	turquoise	turquoise
PDGFRL	turquoise	turquoise	turquoise	turquoise	turquoise
UCHL1	turquoise	turquoise	turquoise	turquoise	turquoise
EPYC	turquoise	turquoise	turquoise	turquoise	turquoise
ITGB5	turquoise	turquoise	turquoise	turquoise	turquoise
GADD45B	turquoise	gray	turquoise	turquoise	turquoise
GLRB	turquoise	turquoise	turquoise	turquoise	turquoise
RGS2	turquoise	turquoise	turquoise	turquoise	turquoise
DIP2C	turquoise	turquoise	turquoise	turquoise	turquoise
TTC7B	turquoise	turquoise	turquoise	turquoise	turquoise
CCDC88A	turquoise	gray	turquoise	turquoise	turquoise
SAMD4A	turquoise	turquoise	turquoise	turquoise	turquoise
F13A1	turquoise	turquoise	turquoise	turquoise	turquoise
MEOX2	turquoise	turquoise	turquoise	turquoise	turquoise
PRELP	turquoise	turquoise	turquoise	turquoise	turquoise
CCL21	turquoise	turquoise	turquoise	turquoise	turquoise
FST	turquoise	turquoise	turquoise	turquoise	turquoise
CALCRL	turquoise	turquoise	turquoise	turquoise	turquoise
LRRN4CL	turquoise	turquoise	turquoise	turquoise	turquoise
ETS1	turquoise	gray	turquoise	turquoise	turquoise
ITPRIP	turquoise	gray	turquoise	turquoise	turquoise
SRPX	turquoise	turquoise	turquoise	turquoise	turquoise
CHRNA3	turquoise	turquoise	turquoise	turquoise	turquoise
PXDC1	turquoise	turquoise	turquoise	turquoise	turquoise
WNT2	turquoise	turquoise	turquoise	turquoise	turquoise
SERPINE1	turquoise	turquoise	turquoise	turquoise	turquoise
PCDH17	turquoise	turquoise	turquoise	turquoise	turquoise
FAM127A	turquoise	turquoise	turquoise	turquoise	turquoise
DACT1	turquoise	turquoise	turquoise	turquoise	turquoise
TMEM45A	turquoise	turquoise	turquoise	turquoise	turquoise
NPR3	turquoise	turquoise	turquoise	turquoise	turquoise
SDK1	turquoise	turquoise	turquoise	turquoise	turquoise
CYGB	turquoise	turquoise	turquoise	turquoise	turquoise
OLFML2A	turquoise	gray	turquoise	turquoise	turquoise
ARL10	turquoise	turquoise	turquoise	turquoise	turquoise
HTR2B	turquoise	turquoise	turquoise	turquoise	turquoise
TCEAL3	turquoise	turquoise	turquoise	turquoise	turquoise
MDFIC	turquoise	turquoise	turquoise	turquoise	turquoise
PALMD	turquoise	turquoise	turquoise	turquoise	turquoise
CILP	turquoise	turquoise	turquoise	turquoise	turquoise
AQP1	turquoise	turquoise	turquoise	turquoise	turquoise
CXCL12	turquoise	turquoise	turquoise	turquoise	turquoise
RERG	turquoise	turquoise	turquoise	turquoise	turquoise
TCEA2	turquoise	turquoise	turquoise	turquoise	turquoise
PBX3	turquoise	turquoise	turquoise	turquoise	turquoise
GLI3	turquoise	turquoise	turquoise	turquoise	turquoise
DSEL	turquoise	turquoise	turquoise	turquoise	turquoise
ADAMTS1	turquoise	turquoise	turquoise	turquoise	turquoise
PTPLAD2	turquoise	turquoise	turquoise	turquoise	turquoise
ALDH1A3	turquoise	turquoise	turquoise	turquoise	turquoise
VWF	turquoise	turquoise	turquoise	turquoise	turquoise
ATP2B4	turquoise	turquoise	turquoise	turquoise	turquoise
CFL2	turquoise	turquoise	turquoise	turquoise	turquoise
ZNF677	turquoise	turquoise	turquoise	turquoise	turquoise
RGS4	turquoise	turquoise	turquoise	turquoise	turquoise
GALNT15	turquoise	turquoise	turquoise	turquoise	turquoise
SYNE1	turquoise	turquoise	gray	turquoise	turquoise
CYP1B1	turquoise	turquoise	turquoise	turquoise	turquoise
TUSC3	turquoise	turquoise	turquoise	turquoise	turquoise
ZNF532	turquoise	turquoise	turquoise	turquoise	turquoise
RSPO3	turquoise	turquoise	turquoise	turquoise	turquoise
NAV1	turquoise	turquoise	turquoise	turquoise	turquoise
QKI	turquoise	gray	turquoise	turquoise	turquoise
THBS4	turquoise	turquoise	turquoise	turquoise	turquoise
CALU	turquoise	gray	turquoise	turquoise	turquoise
STOM	turquoise	turquoise	turquoise	turquoise	turquoise
TIMP1	turquoise	turquoise	turquoise	turquoise	turquoise
RASSF8	turquoise	turquoise	turquoise	turquoise	turquoise
RGMA	turquoise	turquoise	turquoise	turquoise	turquoise
CPXM2	turquoise	turquoise	turquoise	turquoise	turquoise
BTBD19	turquoise	turquoise	turquoise	turquoise	turquoise
ZCCHC24	turquoise	turquoise	gray	turquoise	turquoise
DENND5A	turquoise	turquoise	turquoise	turquoise	turquoise
ELTD1	turquoise	turquoise	turquoise	turquoise	turquoise
LPHN2	turquoise	turquoise	turquoise	turquoise	turquoise
TRPC1	turquoise	turquoise	turquoise	turquoise	turquoise
TPST1	turquoise	turquoise	turquoise	turquoise	turquoise
TGFB1	turquoise	gray	gray	turquoise	turquoise
ISM1	turquoise	turquoise	turquoise	turquoise	turquoise
INMT	turquoise	turquoise	turquoise	turquoise	turquoise
MMP11	turquoise	turquoise	turquoise	turquoise	turquoise
LTBP1	turquoise	turquoise	turquoise	turquoise	turquoise
THBS1	turquoise	turquoise	turquoise	turquoise	turquoise
HSD17B6	turquoise	turquoise	turquoise	turquoise	turquoise
NREP	turquoise	turquoise	turquoise	turquoise	turquoise
SSPN	turquoise	turquoise	turquoise	turquoise	turquoise
C10orf10	turquoise	turquoise	turquoise	turquoise	turquoise
TRPS1	turquoise	turquoise	turquoise	turquoise	turquoise
KLHL5	turquoise	turquoise	turquoise	turquoise	turquoise
ADAMTS5	turquoise	turquoise	turquoise	turquoise	turquoise
SLC24A3	turquoise	turquoise	turquoise	turquoise	turquoise
LMCD1	turquoise	turquoise	turquoise	turquoise	turquoise
ANXA6	turquoise	turquoise	turquoise	turquoise	turquoise
UBE2E2	turquoise	turquoise	turquoise	turquoise	turquoise
C3	turquoise	turquoise	turquoise	turquoise	turquoise
MYO5A	turquoise	gray	turquoise	turquoise	turquoise
HSPG2	turquoise	turquoise	turquoise	turquoise	turquoise
CAV1	turquoise	turquoise	turquoise	turquoise	turquoise
PNMAL1	turquoise	turquoise	turquoise	turquoise	turquoise
CLIC4	turquoise	turquoise	turquoise	turquoise	turquoise
DCHS1	turquoise	turquoise	turquoise	turquoise	turquoise
KCNJ8	turquoise	turquoise	turquoise	turquoise	turquoise
EML1	turquoise	turquoise	turquoise	turquoise	turquoise
TP73-AS1	turquoise	turquoise	gray	turquoise	turquoise
SMARCD3	turquoise	turquoise	turquoise	turquoise	turquoise
MEDAG	turquoise	turquoise	turquoise	turquoise	turquoise
CCL2	turquoise	gray	turquoise	turquoise	turquoise
CLIP4	turquoise	turquoise	turquoise	turquoise	turquoise
DCLK1	turquoise	turquoise	turquoise	turquoise	turquoise
ARMCX2	turquoise	turquoise	turquoise	turquoise	turquoise
CHST15	turquoise	gray	turquoise	turquoise	turquoise
CALHM2	turquoise	turquoise	turquoise	turquoise	turquoise
C1QTNF3	turquoise	turquoise	turquoise	turquoise	turquoise
JAZF1	turquoise	turquoise	turquoise	turquoise	turquoise
KIF26B	turquoise	turquoise	turquoise	turquoise	turquoise
GNG11	turquoise	turquoise	turquoise	turquoise	turquoise
ERG	turquoise	turquoise	turquoise	turquoise	turquoise
GJA1	turquoise	turquoise	turquoise	turquoise	turquoise
RBMS1	turquoise	turquoise	turquoise	turquoise	turquoise
CPXM1	turquoise	turquoise	turquoise	turquoise	turquoise
MFAP4	turquoise	turquoise	turquoise	turquoise	turquoise
ITGBL1	turquoise	turquoise	turquoise	turquoise	turquoise
MMRN2	turquoise	turquoise	turquoise	turquoise	turquoise
FZD1	turquoise	turquoise	turquoise	turquoise	turquoise
LATS2	turquoise	turquoise	turquoise	turquoise	turquoise
CDH5	turquoise	turquoise	turquoise	turquoise	turquoise
SGCE	turquoise	turquoise	turquoise	turquoise	turquoise
NID1	turquoise	turquoise	turquoise	turquoise	turquoise
RBMS3	turquoise	turquoise	turquoise	turquoise	turquoise
PLXDC2	turquoise	turquoise	turquoise	turquoise	turquoise
CYBRD1	turquoise	turquoise	turquoise	turquoise	turquoise
IGFBP3	turquoise	turquoise	turquoise	turquoise	turquoise
EDNRA	turquoise	turquoise	turquoise	turquoise	turquoise
MN1	turquoise	turquoise	turquoise	turquoise	turquoise
HS3ST3A1	turquoise	turquoise	turquoise	turquoise	turquoise
EBF1	turquoise	turquoise	turquoise	turquoise	turquoise
SERPINH1	turquoise	gray	turquoise	turquoise	turquoise
GEM	turquoise	turquoise	turquoise	turquoise	turquoise
TNFAIP6	turquoise	gray	turquoise	turquoise	turquoise
KAL1	turquoise	turquoise	turquoise	turquoise	turquoise
RAI14	turquoise	turquoise	turquoise	turquoise	turquoise
HEYL	turquoise	turquoise	turquoise	turquoise	turquoise
CFH	turquoise	turquoise	turquoise	turquoise	turquoise
PALLD	turquoise	turquoise	turquoise	turquoise	turquoise
TNFSF4	turquoise	turquoise	turquoise	turquoise	turquoise
MXRA7	turquoise	turquoise	turquoise	turquoise	turquoise
PDLIM4	turquoise	turquoise	turquoise	turquoise	turquoise
TMEM119	turquoise	turquoise	turquoise	turquoise	turquoise
NID2	turquoise	turquoise	turquoise	turquoise	turquoise
MYH10	turquoise	turquoise	turquoise	turquoise	turquoise
C11orf96	turquoise	turquoise	turquoise	turquoise	turquoise
MOXD1	turquoise	turquoise	turquoise	turquoise	turquoise
SGCD	turquoise	turquoise	turquoise	turquoise	turquoise
SYT11	turquoise	turquoise	turquoise	turquoise	turquoise
DPT	turquoise	turquoise	turquoise	turquoise	turquoise
COL14A1	turquoise	turquoise	turquoise	turquoise	turquoise
UBE2QL1	turquoise	turquoise	turquoise	turquoise	turquoise
PCDH7	turquoise	turquoise	turquoise	turquoise	turquoise
PLXDC1	turquoise	turquoise	turquoise	turquoise	turquoise
MLLT11	turquoise	turquoise	turquoise	turquoise	turquoise
CLEC11A	turquoise	turquoise	turquoise	turquoise	turquoise
PPP1R18	turquoise	gray	gray	turquoise	turquoise
PLEKHO1	turquoise	gray	gray	turquoise	turquoise
EMP3	turquoise	gray	gray	gray	turquoise
TSPAN4	turquoise	gray	turquoise	turquoise	turquoise
FAM19A5	turquoise	turquoise	turquoise	turquoise	turquoise
LBH	turquoise	turquoise	turquoise	turquoise	turquoise
PRKCDBP	turquoise	turquoise	turquoise	turquoise	turquoise
A2M	turquoise	turquoise	turquoise	turquoise	turquoise
COL8A2	turquoise	turquoise	turquoise	turquoise	turquoise
IGFBP6	turquoise	turquoise	turquoise	turquoise	turquoise
SLIT2	turquoise	turquoise	turquoise	turquoise	turquoise
JAM2	turquoise	turquoise	turquoise	turquoise	turquoise
PDLIM7	turquoise	turquoise	turquoise	turquoise	turquoise
GJC1	turquoise	turquoise	turquoise	turquoise	turquoise
MFAP5	turquoise	turquoise	turquoise	turquoise	turquoise
CDK14	turquoise	turquoise	turquoise	turquoise	turquoise
C3orf80	turquoise	turquoise	turquoise	turquoise	turquoise
PHLDB2	turquoise	turquoise	turquoise	turquoise	turquoise
SPG20	turquoise	turquoise	turquoise	turquoise	turquoise
CYS1	turquoise	turquoise	turquoise	turquoise	turquoise
TIE1	turquoise	turquoise	turquoise	turquoise	turquoise
CHSY3	turquoise	turquoise	turquoise	turquoise	turquoise
TNC	turquoise	turquoise	turquoise	turquoise	turquoise
PKD2	turquoise	turquoise	turquoise	turquoise	turquoise
FAM129A	turquoise	gray	gray	turquoise	turquoise
NEXN	turquoise	turquoise	turquoise	turquoise	turquoise
GAS7	turquoise	turquoise	turquoise	turquoise	turquoise
ECM2	turquoise	turquoise	turquoise	turquoise	turquoise
CYR61	turquoise	turquoise	turquoise	turquoise	turquoise
TCF4	turquoise	turquoise	turquoise	turquoise	turquoise
HMCN1	turquoise	turquoise	turquoise	turquoise	turquoise
PTGIS	turquoise	turquoise	turquoise	turquoise	turquoise
AKAP12	turquoise	turquoise	turquoise	turquoise	turquoise
TMEM47	turquoise	turquoise	turquoise	turquoise	turquoise
LDB2	turquoise	turquoise	turquoise	turquoise	turquoise
CLMP	turquoise	turquoise	turquoise	turquoise	turquoise
MPDZ	turquoise	turquoise	turquoise	turquoise	turquoise
CRISPLD1	turquoise	turquoise	turquoise	turquoise	turquoise
DZIP1	turquoise	turquoise	turquoise	turquoise	turquoise
PRICKLE1	turquoise	turquoise	turquoise	turquoise	turquoise
PRICKLE2	turquoise	turquoise	turquoise	turquoise	turquoise
RECK	turquoise	turquoise	turquoise	turquoise	turquoise
MAP1B	turquoise	turquoise	turquoise	turquoise	turquoise
PPP1R3C	turquoise	turquoise	turquoise	turquoise	turquoise
TCEAL7	turquoise	turquoise	turquoise	turquoise	turquoise
SYNM	turquoise	turquoise	turquoise	turquoise	turquoise
PDE1A	turquoise	turquoise	turquoise	turquoise	turquoise
PEG3	turquoise	turquoise	turquoise	turquoise	turquoise
SYNPO2	turquoise	turquoise	turquoise	turquoise	turquoise
FBLN5	turquoise	turquoise	turquoise	turquoise	turquoise
NAP1L3	turquoise	turquoise	turquoise	turquoise	turquoise
SYNC	turquoise	turquoise	turquoise	turquoise	turquoise
ARMCX1	turquoise	turquoise	turquoise	turquoise	turquoise
SPARCL1	turquoise	turquoise	turquoise	turquoise	turquoise
KCNMB1	turquoise	turquoise	turquoise	turquoise	turquoise
CACNA2D1	turquoise	turquoise	turquoise	turquoise	turquoise
C14orf132	turquoise	turquoise	turquoise	turquoise	turquoise
MYH11	turquoise	turquoise	turquoise	turquoise	turquoise
HSPB8	turquoise	turquoise	turquoise	turquoise	turquoise
DES	turquoise	turquoise	turquoise	turquoise	turquoise
LMOD1	turquoise	turquoise	turquoise	turquoise	turquoise
ACTG2	turquoise	turquoise	turquoise	turquoise	turquoise
PLN	turquoise	turquoise	turquoise	turquoise	turquoise
MAB21L2	turquoise	turquoise	turquoise	turquoise	turquoise
RUNX1T1	turquoise	turquoise	turquoise	turquoise	turquoise
STON1	turquoise	turquoise	turquoise	turquoise	turquoise
BOC	turquoise	turquoise	turquoise	turquoise	turquoise
KANK2	turquoise	turquoise	turquoise	turquoise	turquoise
FXYD6	turquoise	turquoise	turquoise	turquoise	turquoise
C20orf194	turquoise	turquoise	turquoise	turquoise	turquoise
PDLIM3	turquoise	turquoise	turquoise	turquoise	turquoise
MGP	turquoise	turquoise	turquoise	turquoise	turquoise
AOC3	turquoise	turquoise	turquoise	turquoise	turquoise
AMOTL1	turquoise	turquoise	turquoise	turquoise	turquoise
TPM2	turquoise	turquoise	turquoise	turquoise	turquoise
MRVI1	turquoise	turquoise	turquoise	turquoise	turquoise
TSPYL5	turquoise	turquoise	turquoise	turquoise	turquoise
FEZ1	turquoise	turquoise	turquoise	turquoise	turquoise
CNRIP1	turquoise	turquoise	turquoise	turquoise	turquoise
COX7A1	turquoise	turquoise	turquoise	turquoise	turquoise
MRGPRF	turquoise	turquoise	turquoise	turquoise	turquoise
MYLK	turquoise	turquoise	turquoise	turquoise	turquoise
CNN1	turquoise	turquoise	turquoise	turquoise	turquoise
CRYAB	turquoise	turquoise	turquoise	turquoise	turquoise
FILIP1L	turquoise	turquoise	turquoise	turquoise	turquoise
SYNDIG1	turquoise	turquoise	turquoise	turquoise	turquoise
THBD	turquoise	turquoise	turquoise	turquoise	turquoise
MMP19	turquoise	gray	turquoise	turquoise	turquoise
DLC1	turquoise	turquoise	turquoise	turquoise	turquoise
WWTR1	turquoise	turquoise	turquoise	turquoise	turquoise
FLNA	turquoise	turquoise	turquoise	turquoise	turquoise
CD93	turquoise	turquoise	turquoise	turquoise	turquoise
MMP14	turquoise	turquoise	turquoise	turquoise	turquoise
PRKD1	turquoise	turquoise	turquoise	turquoise	turquoise
NDN	turquoise	turquoise	turquoise	turquoise	turquoise
MAGI2-AS3	turquoise	turquoise	turquoise	turquoise	turquoise
COMP	turquoise	turquoise	turquoise	turquoise	turquoise
BASP1	turquoise	gray	turquoise	gray	turquoise
SNAI2	turquoise	turquoise	turquoise	turquoise	turquoise
RARRES2	turquoise	turquoise	turquoise	turquoise	turquoise
CTGF	turquoise	turquoise	turquoise	turquoise	turquoise
AKT3	turquoise	turquoise	turquoise	turquoise	turquoise
IL1R1	turquoise	turquoise	turquoise	turquoise	turquoise
ST6GALNAC5	turquoise	turquoise	turquoise	turquoise	turquoise
BICC1	turquoise	turquoise	turquoise	turquoise	turquoise
KIRREL	turquoise	turquoise	turquoise	turquoise	turquoise
DOK5	turquoise	turquoise	turquoise	turquoise	turquoise
MSN	turquoise	gray	gray	turquoise	turquoise
FAM101B	turquoise	turquoise	turquoise	turquoise	turquoise
LTBP2	turquoise	turquoise	turquoise	turquoise	turquoise
FBLN2	turquoise	turquoise	turquoise	turquoise	turquoise
LRRC15	turquoise	turquoise	turquoise	turquoise	turquoise
LOX	turquoise	turquoise	turquoise	turquoise	turquoise
MFGE8	turquoise	turquoise	turquoise	turquoise	turquoise
FAP	turquoise	turquoise	turquoise	turquoise	turquoise
COLEC12	turquoise	turquoise	turquoise	turquoise	turquoise
FAM20C	turquoise	turquoise	turquoise	turquoise	turquoise
PTPRM	turquoise	turquoise	turquoise	turquoise	turquoise
BCAT1	turquoise	turquoise	turquoise	turquoise	turquoise
MAF	turquoise	turquoise	turquoise	turquoise	turquoise
COL4A1	turquoise	turquoise	turquoise	turquoise	turquoise
TUBA1A	turquoise	turquoise	turquoise	turquoise	turquoise
ENTPD1	turquoise	turquoise	gray	turquoise	turquoise
DFNA5	turquoise	turquoise	turquoise	turquoise	turquoise
FGFR1	turquoise	turquoise	turquoise	turquoise	turquoise
S1PR3	turquoise	turquoise	turquoise	turquoise	turquoise
VGLL3	turquoise	turquoise	turquoise	turquoise	turquoise
ITGA5	turquoise	turquoise	turquoise	turquoise	turquoise
PDPN	turquoise	turquoise	turquoise	turquoise	turquoise
GREM1	turquoise	turquoise	turquoise	turquoise	turquoise
PMP22	turquoise	turquoise	turquoise	turquoise	turquoise
COL18A1	turquoise	turquoise	turquoise	turquoise	turquoise
PDGFC	turquoise	turquoise	turquoise	turquoise	turquoise
FN1	turquoise	turquoise	turquoise	turquoise	turquoise
KCNE4	turquoise	turquoise	turquoise	turquoise	turquoise
GLIS2	turquoise	turquoise	turquoise	turquoise	turquoise
EFEMP1	turquoise	turquoise	turquoise	turquoise	turquoise
ZNF521	turquoise	turquoise	turquoise	turquoise	turquoise
CERCAM	turquoise	turquoise	turquoise	turquoise	turquoise
NOX4	turquoise	turquoise	turquoise	turquoise	turquoise
NUAK1	turquoise	turquoise	turquoise	turquoise	turquoise
COL15A1	turquoise	turquoise	turquoise	turquoise	turquoise
CRISPLD2	turquoise	turquoise	turquoise	turquoise	turquoise
LOXL1	turquoise	turquoise	turquoise	turquoise	turquoise
GFPT2	turquoise	turquoise	turquoise	turquoise	turquoise
INHBA	turquoise	turquoise	turquoise	turquoise	turquoise
WISP1	turquoise	turquoise	turquoise	turquoise	turquoise
DPYSL3	turquoise	turquoise	turquoise	turquoise	turquoise
ZFPM2	turquoise	turquoise	turquoise	turquoise	turquoise
PPAPDC1A	turquoise	turquoise	turquoise	turquoise	turquoise
MITF	turquoise	turquoise	turquoise	turquoise	turquoise
KIAA1462	turquoise	turquoise	turquoise	turquoise	turquoise
OLFML1	turquoise	turquoise	turquoise	turquoise	turquoise
FBLN1	turquoise	turquoise	turquoise	turquoise	turquoise
PRRX1	turquoise	turquoise	turquoise	turquoise	turquoise
MFAP2	turquoise	turquoise	turquoise	turquoise	turquoise
TSHZ3	turquoise	turquoise	turquoise	turquoise	turquoise
TWIST1	turquoise	turquoise	turquoise	turquoise	turquoise
POSTN	turquoise	turquoise	turquoise	turquoise	turquoise
MRAS	turquoise	turquoise	turquoise	turquoise	turquoise
IGFBP7	turquoise	turquoise	turquoise	turquoise	turquoise
TGFB1I1	turquoise	turquoise	turquoise	turquoise	turquoise
NOTCH3	turquoise	turquoise	turquoise	turquoise	turquoise
EFS	turquoise	turquoise	turquoise	turquoise	turquoise
BNC2	turquoise	turquoise	turquoise	turquoise	turquoise
GUCY1A3	turquoise	turquoise	turquoise	turquoise	turquoise
SFRP2	turquoise	turquoise	turquoise	turquoise	turquoise
PXDN	turquoise	turquoise	turquoise	turquoise	turquoise
LUM	turquoise	turquoise	turquoise	turquoise	turquoise
COL4A2	turquoise	turquoise	turquoise	turquoise	turquoise
RCN3	turquoise	turquoise	turquoise	turquoise	turquoise
LOXL2	turquoise	turquoise	turquoise	turquoise	turquoise
RFTN1	turquoise	turquoise	turquoise	turquoise	turquoise
SERPING1	turquoise	gray	gray	turquoise	turquoise
ASPN	turquoise	turquoise	turquoise	turquoise	turquoise
HOPX	turquoise	turquoise	turquoise	turquoise	turquoise
IGFBP5	turquoise	turquoise	turquoise	turquoise	turquoise
CDH11	turquoise	turquoise	turquoise	turquoise	turquoise
VEGFC	turquoise	turquoise	turquoise	turquoise	turquoise
GLT8D2	turquoise	turquoise	turquoise	turquoise	turquoise
SFRP4	turquoise	turquoise	turquoise	turquoise	turquoise
LAMA4	turquoise	turquoise	turquoise	turquoise	turquoise
SDC2	turquoise	turquoise	turquoise	turquoise	turquoise
CTSK	turquoise	turquoise	turquoise	turquoise	turquoise
NNMT	turquoise	turquoise	turquoise	turquoise	turquoise
COL10A1	turquoise	turquoise	turquoise	turquoise	turquoise
GAS1	turquoise	turquoise	turquoise	turquoise	turquoise
DKK3	turquoise	turquoise	turquoise	turquoise	turquoise
CTHRC1	turquoise	turquoise	turquoise	turquoise	turquoise
ADAM12	turquoise	turquoise	turquoise	turquoise	turquoise
SERPINF1	turquoise	turquoise	turquoise	turquoise	turquoise
TIMP3	turquoise	turquoise	turquoise	turquoise	turquoise
AXL	turquoise	turquoise	turquoise	turquoise	turquoise
COL6A2	turquoise	turquoise	turquoise	turquoise	turquoise
C1R	turquoise	turquoise	turquoise	turquoise	turquoise
EMILIN1	turquoise	turquoise	turquoise	turquoise	turquoise
PTRF	turquoise	turquoise	turquoise	turquoise	turquoise
HTRA1	turquoise	turquoise	turquoise	turquoise	turquoise
GUCY1B3	turquoise	turquoise	turquoise	turquoise	turquoise
FIBIN	turquoise	turquoise	turquoise	turquoise	turquoise
LHFP	turquoise	turquoise	turquoise	turquoise	turquoise
MEIS1	turquoise	turquoise	turquoise	turquoise	turquoise
LAYN	turquoise	turquoise	turquoise	turquoise	turquoise
CALD1	turquoise	turquoise	turquoise	turquoise	turquoise
FERMT2	turquoise	turquoise	turquoise	turquoise	turquoise
TNS1	turquoise	turquoise	turquoise	turquoise	turquoise
MYL9	turquoise	turquoise	turquoise	turquoise	turquoise
DDR2	turquoise	turquoise	turquoise	turquoise	turquoise
TAGLN	turquoise	turquoise	turquoise	turquoise	turquoise
JAM3	turquoise	turquoise	turquoise	turquoise	turquoise
ACTA2	turquoise	turquoise	turquoise	turquoise	turquoise
MSRB3	turquoise	turquoise	turquoise	turquoise	turquoise
C1S	turquoise	turquoise	turquoise	turquoise	turquoise
CCDC80	turquoise	turquoise	turquoise	turquoise	turquoise
MXRA8	turquoise	turquoise	turquoise	turquoise	turquoise
OSMR	turquoise	turquoise	turquoise	turquoise	turquoise
MXRA5	turquoise	turquoise	turquoise	turquoise	turquoise
COL6A1	turquoise	turquoise	turquoise	turquoise	turquoise
ISLR	turquoise	turquoise	turquoise	turquoise	turquoise
LGALS1	turquoise	turquoise	turquoise	turquoise	turquoise
ADAMTS2	turquoise	turquoise	turquoise	turquoise	turquoise
ANGPTL2	turquoise	turquoise	turquoise	turquoise	turquoise
COL1A1	turquoise	turquoise	turquoise	turquoise	turquoise
OLFML2B	turquoise	turquoise	turquoise	turquoise	turquoise
NTM	turquoise	turquoise	turquoise	turquoise	turquoise
COL11A1	turquoise	turquoise	turquoise	turquoise	turquoise
FRMD6	turquoise	turquoise	turquoise	turquoise	turquoise
MMP2	turquoise	turquoise	turquoise	turquoise	turquoise
TUBB6	turquoise	turquoise	turquoise	turquoise	turquoise
BGN	turquoise	turquoise	turquoise	turquoise	turquoise
MRC2	turquoise	turquoise	turquoise	turquoise	turquoise
SPOCK1	turquoise	turquoise	turquoise	turquoise	turquoise
ADAMTS12	turquoise	turquoise	turquoise	turquoise	turquoise
PCOLCE	turquoise	turquoise	turquoise	turquoise	turquoise
COL8A1	turquoise	turquoise	turquoise	turquoise	turquoise
FNDC1	turquoise	turquoise	turquoise	turquoise	turquoise
SULF1	turquoise	turquoise	turquoise	turquoise	turquoise
EFEMP2	turquoise	turquoise	turquoise	turquoise	turquoise
PDGFRB	turquoise	turquoise	turquoise	turquoise	turquoise
AEBP1	turquoise	turquoise	turquoise	turquoise	turquoise
THBS2	turquoise	turquoise	turquoise	turquoise	turquoise
THY1	turquoise	turquoise	turquoise	turquoise	turquoise
VIM	turquoise	turquoise	turquoise	turquoise	turquoise
VCAN	turquoise	turquoise	turquoise	turquoise	turquoise
FSTL1	turquoise	turquoise	turquoise	turquoise	turquoise
COL12A1	turquoise	turquoise	turquoise	turquoise	turquoise
ANTXR1	turquoise	turquoise	turquoise	turquoise	turquoise
COL5A2	turquoise	turquoise	turquoise	turquoise	turquoise
COL5A1	turquoise	turquoise	turquoise	turquoise	turquoise
TIMP2	turquoise	turquoise	turquoise	turquoise	turquoise
COL6A3	turquoise	turquoise	turquoise	turquoise	turquoise
COL3A1	turquoise	turquoise	turquoise	turquoise	turquoise
RAB31	turquoise	turquoise	turquoise	turquoise	turquoise
SPARC	turquoise	turquoise	turquoise	turquoise	turquoise
COL1A2	turquoise	turquoise	turquoise	turquoise	turquoise
FBN1	turquoise	turquoise	turquoise	turquoise	turquoise
DCN	turquoise	turquoise	turquoise	turquoise	turquoise
GPC6	turquoise	turquoise	turquoise	turquoise	turquoise
VASH2	turquoise	turquoise	gray	turquoise	turquoise
CLDN11	turquoise	turquoise	turquoise	turquoise	turquoise
SMCR8	black	gray	black	gray
C3orf67	turquoise	gray	turquoise	gray
NKX2-1	turquoise	gray	gray	gray
APBA1	turquoise	gray	gray	gray
TRDV3	turquoise	gray	turquoise	gray
FOXG1	red	gray	gray	red
TF	turquoise	gray	gray	turquoise
KCNAB1	turquoise	turquoise	gray	gray
BAIAP2-AS1	turquoise	turquoise	gray	gray
SMPDL3B	red	gray	gray	red
FIBCD1	turquoise	gray	turquoise	gray
HOXA6	turquoise	turquoise	gray	gray
AKR1C1	turquoise	turquoise	gray	gray
IL11	turquoise	gray	gray	turquoise
TMEM184A	yellow	yellow	yellow	gray
NFASC	turquoise	gray	turquoise	gray
TNFRSF10C	turquoise	gray	gray	gray
KCNQ4	turquoise	gray	turquoise	gray
TFR2	turquoise	gray	turquoise	gray

REFERENCES

Andre, T., C. Boni, et al. (2009). “Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial.” J Clin Oncol 27(19): 3109-3116.
Cersosimo, R. J. (2005). “Oxaliplatin-associated neuropathy: a review.” Ann Pharmacother 39(1): 128-135.
De Sousa, E. M. F., X. Wang, et al. (2013). “Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions.” Nat Med 19(5): 614-618.
Isella, C., A. Terrasi, et al. (2015). “Stromal contribution to the colorectal cancer transcriptome.” Nat Genet 47(4): 312-319.
Kuebler, J. P., H. S. Wieand, et al. (2007). “Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07.” J Clin Oncol 25(16): 2198-2204.
Marisa, L., A. de Reynies, et al. (2013). “Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value.” PLoS Med 10(5): e1001453.
Sadanandam, A., C. A. Lyssiotis, et al. (2013). “A colorectal cancer classification system that associates cellular phenotype and responses to therapy.” Nat Med 19(5): 619-625.
Tournigand, C., T. Andre, et al. (2012). “Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial.” J Clin Oncol 30(27): 3353-3360.

Goblet.like

Inflammatory

We claim:

1. A method of treating a colon cancer patient comprising:

a) obtaining a colon cancer tumor tissue sample from a patient with colon cancer,

b) contacting a genetic sample from said colon cancer tumor tissue sample with a plurality of specific genetic sequence binding targets and measuring the expression level of a panel consisting essentially of 72 genes, wherein the 72 genes are AKAP12, ANKRD44, BGN, BHLHE41, BMP7, C8orf84, CAB39L, CDKN2B, CKMT2, COL11A1, COMP, CPE, CSGALNACT1, CXCL10, CXCL11, CXCL13, CXCL2, CXCL9, CYP1B1, DAPK1, DCBLD2, DPEP1, EPB41L4B, ERAP2, F5, FAP, FGL2, FN1, FNDC1, GBP1, GBP4, GPX3, GRM8, GZMB, HGD, HOXA13, HSD17B2, ID4, IDO1, IL8, INHBA, MFAP5, MGP, MMP11, MMP28, NFIB, OAS2, PAPPA, PIGR, PLA2G12B, POU2AF1, PRAP1, PROM2, PSMB9, PTPRC, ROBO1, SDC2, SELL, SERPINE1, SFRP2, SGK2, SLC4A4, SPARC, SPP1, SSPN, STC1, TACSTD2, TGFBR3, TM4SF1, TYMS, VCAN, and VNN1,

c) obtaining a gene expression signature for said colon cancer tumor tissue from the gene expression level of the panel of 72 genes in b),

d) responsive to the gene expression signature, identifying said colon cancer tumor tissue as being a subtype responsive to oxaliplatin.

2. The method of claim 1 further comprising the step of administering oxaliplatin in combination with 5′ fluorouracil and leucovorin (FULV) to said patient with colon cancer in a).

3. The method of claim 2, wherein the genetic sample comprises cDNA or RNA either in purified form or as a tissue lysate.

4. The method of claim 2, wherein the identified tumor tissue subtype is of the enterocyte tissue type.

5. A method for treating colon cancer in a patient with Stage II or Stage III colon cancer comprising:

a) obtaining a colon cancer tumor tissue sample from a patient with Stage II or Stage III colon cancer,

b) isolating RNA or producing a lysate from the colon cancer tumor tissue sample,

c) contacting said RNA or said lysate with a plurality of sequence specific probes capable of determining the level of expression of a panel of 72 genes, wherein the panel of 72 genes are AKAP12, ANKRD44, BGN, BHLHE41, BMP7, C8orf84, CAB39L, CDKN2B, CKMT2, COL11A1, COMP, CPE, CSGALNACT1, CXCL10, CXCL11, CXCL13, CXCL2, CXCL9, CYP1B1, DAPK1, DCBLD2, DPEP1, EPB41L4B, ERAP2, F5, FAP, FGL2, FN1, FNDC1, GBP1, GBP4, GPX3, GRM8, GZMB, HGD, HOXA13, HSD17B2, ID4, IDO1, IL8, INHBA, MFAP5, MGP, MMP11, MMP28, NFIB, OAS2, PAPPA, PIGR, PLA2G12B, POU2AF1, PRAP1, PROM2, PSMB9, PTPRC, ROBO1, SDC2, SELL, SERPINE1, SFRP2, SGK2, SLC4A4, SPARC, SPP1, SSPN, STC1, TACSTD2, TGFBR3, TM4SF1, TYMS, VCAN, and VNN1,

d) measuring the gene expression level of the panel of 72 genes and obtaining a gene expression signature for said colon cancer tumor tissue from the gene expression level of said genes in c),

e) responsive to the gene expression signature, identifying said colon cancer tumor tissue as being a subtype responsive to oxaliplatin, and

f) administering oxaliplatin to said patient with Stage II or Stage III colon cancer.

6. The method of claim 5, wherein the oxaliplatin is administered in combination with 5′ fluorouracil and leucovorin (FULV).

7. The method of claim 5, wherein the colon cancer tumor tissue sample is a subtype of the enterocyte tissue type.

8. The method according to claim 1 wherein, if the colon cancer tumor tissue is not identified as being of the subtype not responsive to oxaliplatin, then oxaliplatin is not administered to the patient.

9. The method according to claim 5 wherein, if the colon cancer tumor tissue is not identified as being of the subtype not responsive to oxaliplatin, then oxaliplatin is not administered to the patient.

10. The method of claim 1, wherein said patient is a Stage II colon cancer patient.

11. The method of claim 1, wherein said patient is a Stage III colon cancer patient.