US20190021658A1 - Dual purpose wearable patch for measurement and treatment - Google Patents
Dual purpose wearable patch for measurement and treatment Download PDFInfo
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- US20190021658A1 US20190021658A1 US16/141,794 US201816141794A US2019021658A1 US 20190021658 A1 US20190021658 A1 US 20190021658A1 US 201816141794 A US201816141794 A US 201816141794A US 2019021658 A1 US2019021658 A1 US 2019021658A1
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- wearable patch
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
- A61B5/0008—Temperature signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02438—Detecting, measuring or recording pulse rate or heart rate with portable devices, e.g. worn by the patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/103—Detecting, measuring or recording devices for testing the shape, pattern, colour, size or movement of the body or parts thereof, for diagnostic purposes
- A61B5/11—Measuring movement of the entire body or parts thereof, e.g. head or hand tremor, mobility of a limb
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6815—Ear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/683—Means for maintaining contact with the body
- A61B5/6832—Means for maintaining contact with the body using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
- A61N1/0492—Patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/3603—Control systems
- A61N1/36031—Control systems using physiological parameters for adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
- A61B2562/164—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
Definitions
- the present application relates to wearable electronic devices, and in particular, to wearable patches that can attach to human skin.
- Electronic patches can be used for tracking objects and for performing functions such as producing sound, light or vibrations, and so on. As applications and human needs become more sophisticated and complex, electronic patches are required to perform a rapidly increasing number of tasks. Electronic patches are often required to be conformal to curved surfaces, which in the case of human body, can vary overtime.
- NFC Near Field Communication
- a wireless communication standard that enables two devices to quickly establish communication within a short range around radio frequency of 13.56 MHz.
- NFC is more secure than other wireless technologies such as Bluetooth and Wi-Fi because NFC requires two devices in close proximity (e.g. less than 10 cm).
- NFC can also lower cost comparing to other wireless technologies by allowing one of the two devices to be passive (a passive NFC tag).
- Bluetooth is another wireless communication standard for exchanging data over relatively longer distances (in tens of meters). It employs short wavelength UHF radio waves from 2.4 to 2.485 GHz from fixed or mobile devices. Bluetooth devices have evolved to meet the increasing demand for low-power solutions that is required for wearable electronics. Benefited from relatively longer reading distance and active communication, Bluetooth technologies allow wearable patches to continuously monitoring vital information without human interference, which is an advantage over NFC in many applications.
- Wearable patch is an electronic patch to be worn by a user.
- a wearable patch is required to stay on user's skin and operate for an extended period of time from hours to months.
- a wearable patch can contain a micro-electronic system that can be accessed using NFC, Bluetooth, WiFi, or other wireless technologies.
- a wearable patch can be integrated with different sensors for measurements such as vital signs monitoring.
- Cranial Electrotherapy Stimulation utilizes extremely small levels of electrical stimulation across the head of a patient for therapeutic treatment of anxiety, depression, insomnia and chronic pain.
- the presently disclosure discloses a dual-purpose wearable device that can conveniently measure a patient's vital signs and other signals and treat the patient's symptoms.
- the disclosed wearable patch is easy and comfortable to wear by patients and do not require wire connections to heavy equipment.
- measurements and treatments can be conducted by the disclosed dual-purpose wearable patch while a patient fulfills his or her normal daily activities.
- treatments can be timely and dynamically applied which such needs arise according to measurements of vital body signals and other signals.
- effects of treatments can be immediately monitored by the dual-purpose wearable patch after it applies treatment.
- the present invention relates to a dual purpose wearable patch that includes a stretchable and permeable substrate; a sensing unit mounted in the stretchable and permeable substrate, wherein the sensing unit is configured to conduct a measurement of a user to produce a measurement signal; one or more electrodes respectively attached to the stretchable and permeable substrate; a circuit substrate on the stretchable and permeable substrate, wherein the circuit substrate comprises a circuit electrically connected with the one or more electrodes and the sensing unit; and a semiconductor chip mounted on the circuit substrate and in connection with the circuit, wherein the semiconductor chip is configured to receive the measurement signal from the sensing unit, wherein the semiconductor chip can produce a treatment control signal to control the one or more electrodes to apply a voltage across the user's body.
- Implementations of the system may include one or more of the following.
- the semiconductor chip can produce a treatment control signal to control the one or more electrodes to apply a voltage across the user's body in response to a measurement signal.
- the dual-purpose wearable patch can further include a battery configured to supply power to the circuit and the semiconductor chip.
- the semiconductor chip can switch the circuit, the one or more electrodes, and the sensing unit into or off from a measurement mode and a treatment mode.
- the one or more electrodes can include a second electrode and a third electrode configured to apply a voltage across the user's body.
- the sensing unit can include a temperature sensor configured to measure the user's skin temperature, wherein the measurement signal comprises temperature data.
- the sensing unit can further include a thermally conductive cup having a bottom portion mounted in a first opening in the stretchable and permeable substrate, wherein the temperature sensor is positioned inside and is in thermal conduction cup with the conductive cup.
- the sensing unit can include a thermally conductive adhesive that fixes the temperature sensor to an inner surface of the conductive cup, and a thermally insulating material in a top portion of the conductive cup.
- the sensing unit can include an accelerometer configured to measure movement of the user.
- the sensing unit can include a pressure sensor or a force sensor configured to measure blood pressure or pulse of the user.
- the semiconductor chip can control a type, a frequency, or a duration of a measurement of the user by the sensing unit based on the voltage applied across the user's body.
- the dual purpose wearable patch can further include an antenna mounted on the circuit substrate and in electric connection with the semiconductor chip, wherein the semiconductor chip is configured to produce electric signals to enable the antenna to wirelessly exchange measurement data based on the measurement signal with an external device, wherein the semiconductor chip can produce electric signals to enable the antenna to wirelessly exchange treatment data with an external device, wherein the treatment control signal is at least in part based on the treatment data.
- At least one of the one or more electrodes can include an electrically conductive cup that is electrically connected to the control circuit in the circuit substrate, wherein the stretchable and permeable substrate comprises a second opening in which the electrically conductive cup is mounted. The electrically conductive cup can be electrically connected with the circuit.
- the dual-purpose wearable patch can further include an adhesive layer between the stretchable and permeable substrate and the circuit substrate.
- the dual-purpose wearable patch can further include an elastic layer formed on the stretchable and permeable substrate, the circuit substrate, and the sensing unit.
- the sensing unit includes an accelerometer can measure the user's movement, wherein the measurement signal comprises movement data.
- the sensing unit can include a pressure sensor or a force sensor configured to measure the user's blood pressure and/or the user's pulse, wherein the measurement signal comprises pulse data and blood pressure data.
- FIG. 1 illustrates dual-purpose wearable patches attached to a user's skin.
- FIG. 2 is a cross-sectional view of an exemplified dual-purpose wearable patch for both measurement and treatment in accordance with some embodiments of the present invention.
- FIG. 3 is a detailed cross-sectional view of an exemplified sensing unit in the dual-purpose wearable patch of FIG. 2 .
- one or more dual-purpose wearable patches 100 , 101 are attached to the skin of a user 110 for measuring body vital signs.
- the dual-purpose wearable patch 100 can be placed on the ears, the forehead, the hands, the shoulder, the waist, the leg, or the foot, under the armpit, around the wrist, on or around the arm, or other parts of a user's body.
- the term “wearable patch” can also be referred to as “wearable sticker”, “wearable tag”, or “wearable band”, etc.
- dual-purpose wearable patches 100 , 101 can operate individually, or in a group to provide certain desired treatment or measurement.
- the purpose wearable patch 101 can wrap around a user's ear for applying an electric field through certain location of the ear. Similar, the disclosed purpose wearable patch can wrap around a user's wrist for providing treatment and measurement.
- the dual-purpose wearable patches 100 , 101 can be attached to different parts of a user's body such as on the two ears or the two temples of the user 100 , which allows a low electric voltage signal to be applied across the user's head.
- an exemplified dual-purpose wearable patch 200 includes a stretchable and permeable substrate 205 that include openings 210 A, 210 B, 210 C.
- the stretchable and permeable substrate 205 can be made of soft foam materials such as EVA, PE, CR, PORON, EPD, SCF or fabric textile, to provide stretchability and breathability.
- the measurement portion of the disclosed dual-purpose wearable patch 200 includes a sensing unit 300 mounted in the opening 210 C.
- the treatment portion of the disclosed dual-purpose wearable patch 200 includes two electrodes 212 A, 212 B, respectively comprising electrically conductive cups 213 A, 213 B, are mounted in the openings 210 A, 210 B.
- the thermal conductive cup 302 in the sensing unit 300 is electrically connected with the circuit substrate 216 by a conductive line 240 , which in turn establishes electrical communication between the thermal conductive cup 302 and the semiconductor chip 220 .
- An elastic layer 250 is also bonded to the stretchable and permeable substrate 205 by the adhesive layer 215 to the stretchable and permeable substrate 205 .
- the elastic layer 250 is also formed on the circuit substrate 216 , the sensing unit 300 , and the electrodes 212 A, 212 B.
- the elastic layer 250 can be formed by soft stretchable and permeable foam materials such as EVA, PE, CR, PORON, EPD, SCF, or fabric textile.
- a thin film 260 is formed on the elastic layer 250 for protection and cosmetic purposes.
- an adhesive material formed on the lower surface of the stretchable and permeable substrate 205 is attached the user's skin, so that the bottom of the thermal conductive cup 302 is in tight contact with a user's skin to accurately measure temperature, electrical, or pressure signals from the user's skin, or apply electrical, thermal, or mechanical signals to the user's skin.
- the semiconductor chip 220 receives an electric signal from the temperature sensor 301 in response to a temperature measurement of the user's skin.
- the electrically conductive cups 213 A, 213 B in the electrodes 212 A, 212 B are respectively electrically connected to the electric circuit in the circuit substrate 216 by conductive lines 214 A, 214 B (e.g. flexible ribbons embedded with conductive circuits).
- the electrodes 212 A, 212 B can also be implemented in other configurations such as conductive pins, conductive pads, conductive buttons, or conductive strips.
- the semiconductor chip 220 can produce treatment electric signals, which can be amplified by an amplifier (not shown in FIG. 2 ) with power supplied by the battery 225 , which is sent to the electrodes 212 A, 212 B via the conductive lines 214 A, 214 B.
- the electric voltage (typically in low amplitude) generated across the electrodes 212 A, 212 B is applied to the user's skin for therapeutic treatment.
- Cranial Electrotherapy Stimulation treatment can be applied across the electrode in one disclosed dual purpose wearable patch across a user's ear lobe (e.g. 101 in FIG. 1 ) or across a user's wrist.
- electrical voltage signals can be applied across electrodes in two disclosed dual-purpose wearable patches (e.g. 100 , 101 in FIG. 1 ). In this case, a thin conductive wire behind the user's neck can be tethered to the two dual-purpose wearable patches to provide proper ground for the voltage signals.
- the semiconductor chip 220 can communicate with an external device such as a mobile phone or a computer via the antenna 230 in wireless signals.
- the semiconductor chip 220 can receive a treatment plan from the external device.
- the wireless signal can be based on using WiFi, Bluetooth, Near Field Communication (NFC), and other wireless standards.
- the semiconductor chip 220 can general the treatment electric signals at durations, intervals, and amplitudes as defined in the treatment plan.
- the antenna 230 is separated from the user's skin by the circuit substrate 216 and the stretchable and permeable substrate 205 , which minimizes the impact of the user's body on the transmissions of wireless signals by the antenna 230 .
- the sensing unit 300 in the measurement portion of the disclosed dual-purpose wearable patch 200 , includes a temperature sensor 301 in a thermal conductive cup 302 , which has its bottom portion mounted into the large opening 210 C and fixed to the stretchable and permeable substrate 205 by an adhesive.
- the temperature sensor 301 is electrically connected to the electric circuit in the circuit substrate 216 by a flexible conductive ribbon 303 .
- the bottom portion of the thermal conductive cup 302 protrudes out of the lower surface of the stretchable and permeable substrate 205 .
- the lips of the thermal conductive cup 302 near its top portion are fixedly attached or bonded to bonding pads (not shown) on the stretchable and permeable substrate 205 by soldering or with an adhesive.
- the thermal conductive cup 302 is both thermally and electrically conductive.
- the thermal conductive cup 302 can be made of a thermally conductive metallic or alloy material such as copper, stainless steel, ceramic or carbide composite materials.
- the temperature sensor 301 can send an electric signal to the semiconductor chip 220 via the electric circuit in response to a measured temperature.
- the semiconductor chip 220 processes the electric signal and output another electrical signal which enables the antenna 230 to transmit a wireless signal carrying the measurement data to another external device such as a mobile phone or a computer (its wireless signals, as described below, can be boosted by a charging and wireless boosting station).
- the wireless signal can be based on using WiFi, Bluetooth, Near Field Communication (NFC), and other wireless standards.
- the battery 225 powers the semiconductor chip 220 , the antenna 230 , the first and the second electric circuits, and possibly the temperature sensor 301 .
- the temperature sensor 301 can be fixed to an inner surface at the bottom of the thermal conductive cup 302 by a thermally conductive adhesive 304 , which allows effective heat transfer from the bottom of the thermal conductive cup 302 to the temperature sensor 301 .
- the thermally conductive adhesive 304 can include electrically insulative thermally-conductive epoxies and polymers.
- a thermally insulating material 305 filling the top portion of the thermal conductive cup 302 fixes the thermally-conductive adhesive 304 at the bottom of the thermal conductive cup 302 and reduces heat loss from the temperature sensor 301 to the elastic layer (described below) or the environment.
- the flexible conductive ribbon 303 can be bent and laid out along the wall the thermal conductive cup 302 .
- the sensing unit 300 includes an accelerometer that can measure acceleration and movement of the user. In some embodiments, the sensing unit 300 includes a pressure sensor or a force sensor that can measure the user's pulses or blood pressure during or outside treatments.
- the sensing unit 300 includes one or more electrodes for measuring ECG signals.
- the electrode can for example be structured in an electrically conductive cup similar to the thermal conductive cup 302 described above.
- the ECG signal (voltage) can be measured across two of the electrodes or across one of the electrodes and one of the electrodes 212 A, 212 B (used as ground).
- the ECG signals can be measured when the electrotherapy simulation treatment is not conducted.
- the sensing unit 300 can include multiple sensors for temperature, movement, blood pressure, and pulse measurements.
- the semiconductor chip 220 can control the type(s) and frequencies of the measurement(s) by the sensing unit 300 in response to the types of treatment applied. For example, based on the durations, intervals, and amplitudes of the treatment electric signals, the frequencies, the durations and the type(s) of the measurement(s) can be varied to more accurately and more timely monitor the user's health conditions.
- the semiconductor chip 220 can control the circuit to switch the sensing unit 300 and the electrodes 210 A, 210 B into or off from a measurement mode, or into or off from a treatment mode.
- the mode switching can be specified in the treatment plan received from an external device, or dynamically adjusted according to the user's vital signals and responsiveness to treatment.
- the disclosed dual-purpose wearable patch is worn by an individual patient, the disclosed dual-purpose patch is ideal for personalized medical treatment.
- Each treatment plan download into the disclosed dual-purpose wearable patch can be individualized according to the patient's needs.
- the disclosed dual-purpose wearable patch can significantly enhance the effectiveness of individualized treatments for patients.
- treatments can be dynamically adjusted according to the current condition of the user as indicated by the bio vital signals currently measured from the user.
- the disclosed dual-purpose wearable patch is stretchable, compliant, durable, and comfortable to wear by users.
- the disclosed wearable thermometer patch includes a flexible substrate covered and protected by an elastic layer that increases the flexibility and stretchability.
- Another advantage of the disclosed dual-purpose wearable patch is that it can significantly increase wireless communication range by placing the antenna on the upper surface of the circuit substrate.
- the thickness of the substrate as well as the height of the thermally conductive cup can be selected to allow enough distance between the antenna and the user's skin to minimize interference of user's body to the wireless transmission signals.
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Abstract
A dual purpose wearable patch includes a stretchable and permeable substrate, a sensing unit mounted in the stretchable and permeable substrate, wherein the sensing unit can conduct a measurement of a user to produce a measurement signal, one or more electrodes respectively attached to the stretchable and permeable substrate, a circuit substrate on the stretchable and permeable substrate, wherein the circuit substrate includes a circuit electrically connected with the one or more electrodes and the sensing unit, and a semiconductor chip mounted on the circuit substrate and in connection with the circuit. The semiconductor chip can receive the measurement signal from the sensing unit and can produce a treatment control signal to control the one or more electrodes to apply a voltage across the user's body.
Description
- The present application relates to wearable electronic devices, and in particular, to wearable patches that can attach to human skin.
- Electronic patches can be used for tracking objects and for performing functions such as producing sound, light or vibrations, and so on. As applications and human needs become more sophisticated and complex, electronic patches are required to perform a rapidly increasing number of tasks. Electronic patches are often required to be conformal to curved surfaces, which in the case of human body, can vary overtime.
- Electronic patches can communicate with smart phones and other devices using WiFi, Bluetooth, Near Field Communication (NFC), and other wireless technologies. NFC is a wireless communication standard that enables two devices to quickly establish communication within a short range around radio frequency of 13.56 MHz. NFC is more secure than other wireless technologies such as Bluetooth and Wi-Fi because NFC requires two devices in close proximity (e.g. less than 10 cm). NFC can also lower cost comparing to other wireless technologies by allowing one of the two devices to be passive (a passive NFC tag).
- Bluetooth is another wireless communication standard for exchanging data over relatively longer distances (in tens of meters). It employs short wavelength UHF radio waves from 2.4 to 2.485 GHz from fixed or mobile devices. Bluetooth devices have evolved to meet the increasing demand for low-power solutions that is required for wearable electronics. Benefited from relatively longer reading distance and active communication, Bluetooth technologies allow wearable patches to continuously monitoring vital information without human interference, which is an advantage over NFC in many applications.
- Wearable patch (or tag) is an electronic patch to be worn by a user. A wearable patch is required to stay on user's skin and operate for an extended period of time from hours to months. A wearable patch can contain a micro-electronic system that can be accessed using NFC, Bluetooth, WiFi, or other wireless technologies. A wearable patch can be integrated with different sensors for measurements such as vital signs monitoring.
- Traditionally, treatments can be conducted on patients using probes wire connected with heavy immobile equipment. For example, Cranial Electrotherapy Stimulation (CES) utilizes extremely small levels of electrical stimulation across the head of a patient for therapeutic treatment of anxiety, depression, insomnia and chronic pain.
- There is therefore a need for convenient measurement of a patient's vital signs and other signals and treatment of the patient's symptoms.
- The presently disclosure discloses a dual-purpose wearable device that can conveniently measure a patient's vital signs and other signals and treat the patient's symptoms. The disclosed wearable patch is easy and comfortable to wear by patients and do not require wire connections to heavy equipment.
- Moreover, measurements and treatments can be conducted by the disclosed dual-purpose wearable patch while a patient fulfills his or her normal daily activities. Thus treatments can be timely and dynamically applied which such needs arise according to measurements of vital body signals and other signals.
- Furthermore, effects of treatments can be immediately monitored by the dual-purpose wearable patch after it applies treatment.
- In one general aspect, the present invention relates to a dual purpose wearable patch that includes a stretchable and permeable substrate; a sensing unit mounted in the stretchable and permeable substrate, wherein the sensing unit is configured to conduct a measurement of a user to produce a measurement signal; one or more electrodes respectively attached to the stretchable and permeable substrate; a circuit substrate on the stretchable and permeable substrate, wherein the circuit substrate comprises a circuit electrically connected with the one or more electrodes and the sensing unit; and a semiconductor chip mounted on the circuit substrate and in connection with the circuit, wherein the semiconductor chip is configured to receive the measurement signal from the sensing unit, wherein the semiconductor chip can produce a treatment control signal to control the one or more electrodes to apply a voltage across the user's body.
- Implementations of the system may include one or more of the following. The semiconductor chip can produce a treatment control signal to control the one or more electrodes to apply a voltage across the user's body in response to a measurement signal. The dual-purpose wearable patch can further include a battery configured to supply power to the circuit and the semiconductor chip. The semiconductor chip can switch the circuit, the one or more electrodes, and the sensing unit into or off from a measurement mode and a treatment mode. The one or more electrodes can include a second electrode and a third electrode configured to apply a voltage across the user's body. The sensing unit can include a temperature sensor configured to measure the user's skin temperature, wherein the measurement signal comprises temperature data. The sensing unit can further include a thermally conductive cup having a bottom portion mounted in a first opening in the stretchable and permeable substrate, wherein the temperature sensor is positioned inside and is in thermal conduction cup with the conductive cup. The sensing unit can include a thermally conductive adhesive that fixes the temperature sensor to an inner surface of the conductive cup, and a thermally insulating material in a top portion of the conductive cup. The sensing unit can include an accelerometer configured to measure movement of the user. The sensing unit can include a pressure sensor or a force sensor configured to measure blood pressure or pulse of the user. The semiconductor chip can control a type, a frequency, or a duration of a measurement of the user by the sensing unit based on the voltage applied across the user's body. The dual purpose wearable patch can further include an antenna mounted on the circuit substrate and in electric connection with the semiconductor chip, wherein the semiconductor chip is configured to produce electric signals to enable the antenna to wirelessly exchange measurement data based on the measurement signal with an external device, wherein the semiconductor chip can produce electric signals to enable the antenna to wirelessly exchange treatment data with an external device, wherein the treatment control signal is at least in part based on the treatment data. At least one of the one or more electrodes can include an electrically conductive cup that is electrically connected to the control circuit in the circuit substrate, wherein the stretchable and permeable substrate comprises a second opening in which the electrically conductive cup is mounted. The electrically conductive cup can be electrically connected with the circuit. The dual-purpose wearable patch can further include an adhesive layer between the stretchable and permeable substrate and the circuit substrate. The dual-purpose wearable patch can further include an elastic layer formed on the stretchable and permeable substrate, the circuit substrate, and the sensing unit. The sensing unit includes an accelerometer can measure the user's movement, wherein the measurement signal comprises movement data. The sensing unit can include a pressure sensor or a force sensor configured to measure the user's blood pressure and/or the user's pulse, wherein the measurement signal comprises pulse data and blood pressure data.
- These and other aspects, their implementations and other features are described in detail in the drawings, the description and the claims.
-
FIG. 1 illustrates dual-purpose wearable patches attached to a user's skin. -
FIG. 2 is a cross-sectional view of an exemplified dual-purpose wearable patch for both measurement and treatment in accordance with some embodiments of the present invention. -
FIG. 3 is a detailed cross-sectional view of an exemplified sensing unit in the dual-purpose wearable patch ofFIG. 2 . - Referring to
FIG. 1 , one or more dual-purpose wearable patches user 110 for measuring body vital signs. The dual-purposewearable patch 100 can be placed on the ears, the forehead, the hands, the shoulder, the waist, the leg, or the foot, under the armpit, around the wrist, on or around the arm, or other parts of a user's body. In the present disclosure, the term “wearable patch” can also be referred to as “wearable sticker”, “wearable tag”, or “wearable band”, etc. - As discussed in more detail below, dual-
purpose wearable patches wearable patch 101 can wrap around a user's ear for applying an electric field through certain location of the ear. Similar, the disclosed purpose wearable patch can wrap around a user's wrist for providing treatment and measurement. Moreover, the dual-purpose wearable patches user 100, which allows a low electric voltage signal to be applied across the user's head. - In accordance to the present invention, the disclosed dual-purpose wearable patch includes a treatment portion and a measurement portion. The measurement portion can measure vital signs, motion track, skin temperature, and ECG signals. The treatment portion can apply electrical signals, heat, and sometimes force or pressure to user's body.
- In some embodiments, referring to
FIGS. 2 and 3 , an exemplified dual-purposewearable patch 200 includes a stretchable andpermeable substrate 205 that includeopenings permeable substrate 205 can be made of soft foam materials such as EVA, PE, CR, PORON, EPD, SCF or fabric textile, to provide stretchability and breathability. The measurement portion of the disclosed dual-purpose wearable patch 200 includes asensing unit 300 mounted in the opening 210C. The treatment portion of the disclosed dual-purpose wearable patch 200 includes twoelectrodes conductive cups openings circuit substrate 216 and abattery 225 are bonded to the stretchable andpermeable substrate 205 by anadhesive layer 215 pre-laminated on the stretchable andpermeable substrate 205. Asemiconductor chip 220 and anantenna 230 are mounted on thecircuit substrate 216. Thecircuit substrate 216 includes an electric circuit therein, which can for example be implemented with a printed circuit board. - The thermal
conductive cup 302 in thesensing unit 300 is electrically connected with thecircuit substrate 216 by aconductive line 240, which in turn establishes electrical communication between the thermalconductive cup 302 and thesemiconductor chip 220. - An
elastic layer 250 is also bonded to the stretchable andpermeable substrate 205 by theadhesive layer 215 to the stretchable andpermeable substrate 205. Theelastic layer 250 is also formed on thecircuit substrate 216, thesensing unit 300, and theelectrodes elastic layer 250 can be formed by soft stretchable and permeable foam materials such as EVA, PE, CR, PORON, EPD, SCF, or fabric textile. Athin film 260 is formed on theelastic layer 250 for protection and cosmetic purposes. - In usage, an adhesive material formed on the lower surface of the stretchable and
permeable substrate 205 is attached the user's skin, so that the bottom of the thermalconductive cup 302 is in tight contact with a user's skin to accurately measure temperature, electrical, or pressure signals from the user's skin, or apply electrical, thermal, or mechanical signals to the user's skin. Thesemiconductor chip 220 receives an electric signal from thetemperature sensor 301 in response to a temperature measurement of the user's skin. - In some embodiments, the electrically
conductive cups electrodes circuit substrate 216 byconductive lines electrodes semiconductor chip 220 can produce treatment electric signals, which can be amplified by an amplifier (not shown inFIG. 2 ) with power supplied by thebattery 225, which is sent to theelectrodes conductive lines - In some embodiments, the electric voltage (typically in low amplitude) generated across the
electrodes FIG. 1 ) or across a user's wrist. In another example, electrical voltage signals can be applied across electrodes in two disclosed dual-purpose wearable patches (e.g. 100, 101 inFIG. 1 ). In this case, a thin conductive wire behind the user's neck can be tethered to the two dual-purpose wearable patches to provide proper ground for the voltage signals. - The
semiconductor chip 220 can communicate with an external device such as a mobile phone or a computer via theantenna 230 in wireless signals. For example, thesemiconductor chip 220 can receive a treatment plan from the external device. The wireless signal can be based on using WiFi, Bluetooth, Near Field Communication (NFC), and other wireless standards. Thesemiconductor chip 220 can general the treatment electric signals at durations, intervals, and amplitudes as defined in the treatment plan. - When the dual-purpose
wearable patch 200 is worn by a user, theantenna 230 is separated from the user's skin by thecircuit substrate 216 and the stretchable andpermeable substrate 205, which minimizes the impact of the user's body on the transmissions of wireless signals by theantenna 230. - In some embodiments, the
semiconductor chip 220 can general the treatment electric signals at durations, intervals, and amplitudes based on the measurement data obtained from thesensing unit 300, as described below. For example, the electrotherapy stimulation treatment can be adjusted based on the user's skin temperature, heartbeats, and blood pressure measured by thesensing unit 300. User's bio vital signals may indicate user's stress levels, which can be treated by appropriate waveforms of electrical signals. - In some embodiments, in the measurement portion of the disclosed dual-purpose
wearable patch 200, thesensing unit 300 includes atemperature sensor 301 in a thermalconductive cup 302, which has its bottom portion mounted into thelarge opening 210C and fixed to the stretchable andpermeable substrate 205 by an adhesive. Thetemperature sensor 301 is electrically connected to the electric circuit in thecircuit substrate 216 by a flexibleconductive ribbon 303. Referring toFIG. 3 , the bottom portion of the thermalconductive cup 302 protrudes out of the lower surface of the stretchable andpermeable substrate 205. The lips of the thermalconductive cup 302 near its top portion are fixedly attached or bonded to bonding pads (not shown) on the stretchable andpermeable substrate 205 by soldering or with an adhesive. The thermalconductive cup 302 is both thermally and electrically conductive. The thermalconductive cup 302 can be made of a thermally conductive metallic or alloy material such as copper, stainless steel, ceramic or carbide composite materials. - The
temperature sensor 301 is attached to an inner surface near the bottom of the thermalconductive cup 302. Thetemperature sensor 301 can be implemented, for example, by a thermistor, a Resistor Temperature Detector, or a Thermocouple. Thetemperature sensor 301 is in thermal conduction with the thermalconductive cup 302. When an outer surface of the bottom portion of the thermalconductive cup 302 is in contact with a user's skin, the thermalconductive cup 302 thus effectively transfers heat from a user's skin to thetemperature sensor 301. A flexibleconductive ribbon 303 is connected to thetemperature sensor 301 in the thermalconductive cup 302 and to the electric circuit in the stretchable andpermeable substrate 205. - The
temperature sensor 301 can send an electric signal to thesemiconductor chip 220 via the electric circuit in response to a measured temperature. Thesemiconductor chip 220 processes the electric signal and output another electrical signal which enables theantenna 230 to transmit a wireless signal carrying the measurement data to another external device such as a mobile phone or a computer (its wireless signals, as described below, can be boosted by a charging and wireless boosting station). The wireless signal can be based on using WiFi, Bluetooth, Near Field Communication (NFC), and other wireless standards. Thebattery 225 powers thesemiconductor chip 220, theantenna 230, the first and the second electric circuits, and possibly thetemperature sensor 301. - The
temperature sensor 301 can be fixed to an inner surface at the bottom of the thermalconductive cup 302 by a thermallyconductive adhesive 304, which allows effective heat transfer from the bottom of the thermalconductive cup 302 to thetemperature sensor 301. Examples of the thermally conductive adhesive 304 can include electrically insulative thermally-conductive epoxies and polymers. A thermally insulatingmaterial 305 filling the top portion of the thermalconductive cup 302 fixes the thermally-conductive adhesive 304 at the bottom of the thermalconductive cup 302 and reduces heat loss from thetemperature sensor 301 to the elastic layer (described below) or the environment. The flexibleconductive ribbon 303 can be bent and laid out along the wall the thermalconductive cup 302. - Further details of the sensing unit are disclosed in the commonly assigned co-pending U.S. patent application Ser. No. 15/224,121 “Wearable thermometer patch for accurate measurement of human skin temperature”, filed Jul. 29, 2016, the disclosure of which is incorporated herein by reference.
- In some embodiments, the
sensing unit 300 includes an accelerometer that can measure acceleration and movement of the user. In some embodiments, thesensing unit 300 includes a pressure sensor or a force sensor that can measure the user's pulses or blood pressure during or outside treatments. - In some embodiments, the
sensing unit 300 includes one or more electrodes for measuring ECG signals. The electrode can for example be structured in an electrically conductive cup similar to the thermalconductive cup 302 described above. The ECG signal (voltage) can be measured across two of the electrodes or across one of the electrodes and one of theelectrodes - In some embodiments, the
sensing unit 300 can include multiple sensors for temperature, movement, blood pressure, and pulse measurements. - In some embodiments, the
semiconductor chip 220 can control the type(s) and frequencies of the measurement(s) by thesensing unit 300 in response to the types of treatment applied. For example, based on the durations, intervals, and amplitudes of the treatment electric signals, the frequencies, the durations and the type(s) of the measurement(s) can be varied to more accurately and more timely monitor the user's health conditions. - The
semiconductor chip 220 can control the circuit to switch thesensing unit 300 and theelectrodes - Since the disclosed dual-purpose wearable patch is worn by an individual patient, the disclosed dual-purpose patch is ideal for personalized medical treatment. Each treatment plan download into the disclosed dual-purpose wearable patch can be individualized according to the patient's needs.
- Moreover, the disclosed dual-purpose wearable patch can significantly enhance the effectiveness of individualized treatments for patients. In particular, treatments can be dynamically adjusted according to the current condition of the user as indicated by the bio vital signals currently measured from the user.
- Other details about wearable patches capable of performing measurement and charging functions are disclosed in commonly assigned U.S. patent application Ser. No. 15/423,585, titled “A wearable patch comprising three electrodes for measurement and charging”, filed Feb. 3, 2017, commonly assigned U.S. patent application Ser. No. 15/406,380, titled “A wearable thermometer patch for correct measurement of human skin temperature”, filed Jan. 13, 2017, and commonly assigned U.S. patent application Ser. No. 15/414,549, titled “A wearable thermometer patch for measuring temperature and electrical signals”, filed Jan. 24, 2017. The disclosures in the above applications are incorporated herein by reference.
- The disclosed dual-purpose wearable patch is stretchable, compliant, durable, and comfortable to wear by users. The disclosed wearable thermometer patch includes a flexible substrate covered and protected by an elastic layer that increases the flexibility and stretchability.
- Another advantage of the disclosed dual-purpose wearable patch is that it can significantly increase wireless communication range by placing the antenna on the upper surface of the circuit substrate. The thickness of the substrate as well as the height of the thermally conductive cup can be selected to allow enough distance between the antenna and the user's skin to minimize interference of user's body to the wireless transmission signals.
- While this document contains many specifics, these should not be construed as limitations on the scope of an invention that is claimed or of what may be claimed, but rather as descriptions of features specific to particular embodiments. Certain features that are described in this document in the context of separate embodiments can also be implemented in combination in a single embodiment. Conversely, various features that are described in the context of a single embodiment can also be implemented in multiple embodiments separately or in any suitable sub-combination. Moreover, although features may be described above as acting in certain combinations and even initially claimed as such, one or more features from a claimed combination can in some cases be excised from the combination, and the claimed combination may be directed to a sub-combination or a variation of a sub-combination.
- Only a few examples and implementations are described. Other implementations, variations, modifications and enhancements to the described examples and implementations may be made without deviating from the spirit of the present invention.
Claims (20)
1. A wearable patch, comprising:
a stretchable substrate;
two electrodes respectively attached to the stretchable substrate, wherein the two electrodes are configured to be in electrical contact with the user's skin and to apply a voltage across the user's body, wherein at least one of the two electrodes includes an upper portion and a lower portion, wherein the lower portion is configured to be in electrical contact with the user's skin;
a circuit substrate on the stretchable substrate, wherein the circuit substrate comprises a circuit electrically connected with the two electrodes; and
a semiconductor chip mounted on the circuit substrate and in connection with the circuit, wherein the semiconductor chip is configured to produce a treatment control signal to control the two electrodes to apply a voltage across the user's body.
2. The wearable patch of claim 1 , wherein at least one of the two electrodes comprises an electrically conductive cup electrically connected with the circuit, wherein the stretchable substrate comprises a first opening in which the electrically conductive cup is mounted.
3. The wearable patch of claim 2 , wherein the electrically conductive cup comprises a bottom portion configured to be in contact with the user's skin.
4. The wearable patch of claim 1 , wherein the semiconductor chip is configured to produce a treatment control signal to control the two electrodes to apply a voltage across the user's body in response to a measurement signal.
5. The wearable patch of claim 1 , further comprising:
an antenna mounted on the circuit substrate and in electric connection with the semiconductor chip, wherein the semiconductor chip is configured to produce electric signals to enable the antenna to wirelessly exchange treatment data with an external device, wherein the treatment control signal is at least in part based on the treatment data.
6. The wearable patch of claim 1 , further comprising:
a sensing unit mounted in the stretchable substrate and electrically connected with the circuit, wherein the sensing unit is configured to conduct a measurement of a user to produce a measurement signal, wherein the semiconductor chip is configured to receive the measurement signal from the sensing unit,
7. The wearable patch of claim 6 , wherein the semiconductor chip is configured to produce a treatment control signal to control the two electrodes to apply a voltage across the user's body in conjunction with the measurement conducted by the sensing unit.
8. The wearable patch of claim 6 , wherein the sensing unit includes a bottom portion adapted to be in direct contact with a user's skin
9. The wearable patch of claim 6 , wherein the sensing unit comprises a temperature sensor in thermal contact with the bottom portion to conduct the measurement of a user to produce the measurement signal.
10. The wearable patch of claim 9 , wherein the sensing unit further includes a thermally conductive cup having the bottom portion mounted in a second opening in the stretchable substrate, wherein the temperature sensor is positioned inside and is in thermal conduction cup with the conductive cup, wherein the bottom portion of the thermally conductive cup is configured to be in contact with the user's skin.
11. The wearable patch of claim 10 , wherein the sensing unit comprises:
a thermally-conductive adhesive that fixes the temperature sensor to an inner surface of the conductive cup; and
a thermally insulating material in a top portion of the conductive cup.
12. The wearable patch of claim 9 , wherein the temperature sensor is configured to measure the user's skin temperature, wherein the measurement signal comprises temperature data.
13. The wearable patch of claim 6 , wherein the sensing unit includes an accelerometer configured to measure the user's movement, wherein the measurement signal comprises movement data.
14. The wearable patch of claim 6 , wherein the sensing unit includes a pressure sensor or a force sensor configured to measure the user's blood pressure and/or the user's pulse, wherein the measurement signal comprises pulse data and blood pressure data.
15. The wearable patch of claim 6 , wherein the sensing unit includes a first electrode that is configured to measure an electrical signal from the user's body in conjunction with the two electrodes attached to the stretchable substrate.
16. The wearable patch of claim 6 , wherein the semiconductor chip is configured to switch the circuit, the two electrodes, and the sensing unit into or off from a measurement mode and a treatment mode.
17. The wearable patch of claim 6 , wherein the sensing unit includes an accelerometer configured to measure movement of the user.
18. The wearable patch of claim 6 , wherein the sensing unit includes a pressure sensor or a force sensor configured to measure blood pressure or pulse of the user.
19. The wearable patch of claim 6 , wherein the semiconductor chip is configured to control the sensing unit based on the voltage applied across the user's body, wherein the semiconductor chip is configured to vary a frequency, or a duration of the measurement by the sensing unit.
20. The wearable patch of claim 6 , further comprising:
an antenna mounted on the circuit substrate and in electric connection with the semiconductor chip, wherein the semiconductor chip is configured to produce electric signals to enable the antenna to wirelessly exchange measurement data based on the measurement signal with an external device.
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US16/141,794 US20190021658A1 (en) | 2017-03-13 | 2018-09-25 | Dual purpose wearable patch for measurement and treatment |
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US15/457,532 US10111618B2 (en) | 2017-03-13 | 2017-03-13 | Dual purpose wearable patch for measurement and treatment |
US16/141,794 US20190021658A1 (en) | 2017-03-13 | 2018-09-25 | Dual purpose wearable patch for measurement and treatment |
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WO2021104207A1 (en) * | 2019-11-27 | 2021-06-03 | 未来穿戴技术有限公司 | Massage head and massager |
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WO2018115461A1 (en) * | 2016-12-22 | 2018-06-28 | Fleming Medical Ltd. | A dressing system |
FR3084556B1 (en) * | 2018-07-30 | 2020-11-06 | Commissariat Energie Atomique | FLEXIBLE ELECTRONIC STRUCTURE AND ITS DEVELOPMENT PROCESS. |
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US5423874A (en) * | 1994-03-24 | 1995-06-13 | D'alerta; Mario | Patch for applying pain reducing electrical energy to the body |
EP1379161B1 (en) * | 2001-02-08 | 2006-11-08 | Mini-Mitter Company, Inc | Skin patch including a temperature sensor |
US20030014091A1 (en) * | 2001-05-25 | 2003-01-16 | Rastegar Jahangir S. | Implantable wireless and battery-free communication system for diagnostics sensors |
WO2006026748A1 (en) | 2004-08-31 | 2006-03-09 | Lifescan Scotland Limited | Method of manufacturing an auto-calibrating sensor |
CN101129101B (en) * | 2005-02-28 | 2010-07-14 | 联邦科学和工业研究组织 | Flexible electronic device |
EP2194847A1 (en) * | 2007-09-14 | 2010-06-16 | Corventis, Inc. | Adherent device with multiple physiological sensors |
US20090171180A1 (en) | 2007-12-28 | 2009-07-02 | Trevor Pering | Method and apparatus for configuring wearable sensors |
WO2012129129A2 (en) * | 2011-03-18 | 2012-09-27 | Augustine Biomedical And Design Llc | Non-invasive core temperature sensor |
US8717165B2 (en) | 2011-03-22 | 2014-05-06 | Tassilo Gernandt | Apparatus and method for locating, tracking, controlling and recognizing tagged objects using RFID technology |
US9277864B2 (en) * | 2012-05-24 | 2016-03-08 | Vital Connect, Inc. | Modular wearable sensor device |
CA2913074C (en) * | 2013-05-30 | 2023-09-12 | Graham H. Creasey | Topical neurological stimulation |
US20160015962A1 (en) * | 2014-07-16 | 2016-01-21 | Mehdi Shokoueinejad Maragheh | Smart Patch For Wound Management |
US10279200B2 (en) * | 2014-07-17 | 2019-05-07 | Elwha Llc | Monitoring and treating pain with epidermal electronics |
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WO2021104207A1 (en) * | 2019-11-27 | 2021-06-03 | 未来穿戴技术有限公司 | Massage head and massager |
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