US20180306661A1 - System and Method for Measuring Volume and Pressure - Google Patents
System and Method for Measuring Volume and Pressure Download PDFInfo
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- US20180306661A1 US20180306661A1 US15/769,179 US201615769179A US2018306661A1 US 20180306661 A1 US20180306661 A1 US 20180306661A1 US 201615769179 A US201615769179 A US 201615769179A US 2018306661 A1 US2018306661 A1 US 2018306661A1
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Images
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L11/00—Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group G01L7/00 or G01L9/00
- G01L11/02—Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by means not provided for in group G01L7/00 or G01L9/00 by optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F23/00—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm
- G01F23/22—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water
- G01F23/28—Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring the variations of parameters of electromagnetic or acoustic waves applied directly to the liquid or fluent solid material
- G01F23/284—Electromagnetic waves
- G01F23/292—Light, e.g. infrared or ultraviolet
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
- G01L19/0092—Pressure sensor associated with other sensors, e.g. for measuring acceleration or temperature
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
- G01F22/02—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for involving measurement of pressure
Definitions
- present invention relates to measuring fluid volumes and pressures, and more particularly to an imaging system for measuring fluid volumes and pressures.
- a volume measurement system for a fluid processing device includes a fluid container, an imaging unit and a controller.
- the fluid container may include a fluid container housing that defines the structure of the fluid container, and a plurality of fluid chambers within the fluid container housing.
- the fluid chambers may be configured to collect and/or store fluid from the fluid processing device, and each of the fluid chambers may have a port that allows fluid to enter or exit the fluid chamber.
- the imaging unit may take images of the fluid chambers and may be positioned to view a level of fluid in each of the fluid chambers.
- the controller may be in communication with the imaging unit and may determine a volume of fluid within each of the fluid chambers based upon the viewed level of fluid in each fluid chamber.
- the system may also include a housing (e.g., a system housing) that defines the structure of the volume measurement system.
- the imaging unit and controller may be located within the housing, and at least a portion of a first wall of the system housing may be transparent to allow the imaging unit to view the fluid container and take the images.
- the system/housing may include an opaque cover that holds the fluid container in place when closed.
- the fluid container may be located between the opaque cover and the first wall when installed in the volume measurement system.
- the imaging unit may include a camera that takes the images of the plurality of fluid chambers, and a light source that is directed at the fluid container.
- the light source may illuminate the fluid chambers to allow the camera to take the images of the fluid chambers.
- the imaging unit may be a solid state imager and/or include a wide angle lens.
- the imaging unit and/or controller may be part of the fluid processing device.
- the fluid container may also include a plurality of pressure chambers within the housing.
- Each of the pressure chambers may have a chamber volume that is fluidly connectable with a fluid flow line within the fluid processing device. The fluid/pressure within the flow line may compress the chamber volume when fluidly connected.
- Each of the pressure chambers may include a tube having an open end and a closed end. The tube may define the chamber volume, and the chamber volume may be fluidly connectable with the fluid flow line via the open end. The inner diameter of the tube may be dependent on a target pressure range for the pressure chamber.
- the imaging unit may take images of the plurality of pressure chambers, and the controller may determine a pressure level within the pressure chambers based on the image of the pressure chambers. The controller may use a look-up table to determine the pressure level and/or volume of fluid.
- the housing of the fluid container may include a first and second sheet of flexible material that are secured together to form the fluid chambers and/or the pressure chambers.
- the first and second sheets of material may be PVC and RF welded together.
- the housing may have a plurality of reference marks on each of the fluid chambers that provide an indication of a fluid level in each of the fluid chambers.
- the fluid level may be related to the volume of fluid within the fluid chamber.
- the fluid container may have perforations that allow the fluid chambers and/or pressure chambers to be separated from one another.
- One or more of the fluid chambers may be V-shaped.
- a method of measuring a volume of fluid within a fluid container may include providing a fluid container having a plurality of fluid chambers and fluidly connecting each of the fluid chambers to a fluid line on the fluid processing system via a port on the fluid chambers.
- the fluid container may also include a fluid container housing defining the structure of the fluid container.
- the fluid chambers may be within the housing and configured to collect and/or store fluid from the fluid processing system.
- the ports may allow fluid to enter or exit each of the fluid chambers.
- the method may also include installing the fluid container into a volume measurement device.
- the volume measurement device may have an imaging unit that takes images of the fluid chambers and is positioned to view a level of fluid in each of the fluid chambers. The method may then image each of the fluid chambers using the imaging unit, and determine, using a controller in communication with the imaging unit, a volume of fluid within each of the fluid chambers based upon the images of the fluid chambers.
- the volume measurement device may include a system housing defining the structure of the volume measurement device.
- the imaging unit and controller may be located within the housing, and at least a portion of a first wall of the system housing may be clear to allow the imaging unit to view the fluid container and take the images.
- the system housing may also have an opaque cover, and installing the fluid container into the volume measurement device may include closing the opaque cover over the fluid container to secure the fluid container within the volume measurement device.
- the imaging unit may include (1) a camera configured to take the images of the fluid chambers, and (2) a light source directed at the fluid container and configured to illuminate the fluid chambers to allow the camera to take the images of the fluid chambers.
- the imaging unit may be a solid state imager and/or include a wide angle lens.
- the volume measurement device may be part of the fluid processing system.
- the fluid container may include a plurality of pressure chambers within the housing and having chamber volumes.
- the method may include fluidly connecting each of the pressure chambers to a fluid flow line within the fluid processing system, such that a pressure/fluid within the flow line compresses the chamber volume. Additionally, the method may image each of the pressure chambers using the imaging unit, and determine, using the controller, a pressure level within each of the pressure chambers based on the image of the pressure chamber.
- Each of the pressure chambers may include a tube with an open end and a closed end.
- the tube may define the chamber volume, and the chamber volume may be in fluid communication with the fluid flow line via the open end.
- the inner diameter of the tube may be dependent on a target pressure range for the pressure chamber.
- the controller may use a look-up table to determine the pressure level within each of the pressure chambers.
- the fluid container housing may include a first sheet and second sheet of flexible material (e.g., PVC) that are secured together (e.g., via RF welding) to form the plurality of fluid chambers and/or pressure chambers.
- the housing may have plurality of reference marks on each of the fluid chambers that provide an indication of the fluid level in each of the fluid chambers.
- the fluid level may be related to a volume of fluid within the fluid chamber.
- a fluid container for a fluid processing system includes a housing defining the structure of the fluid container, a plurality of fluid chambers within the housing, and a plurality of pressure chambers within the housing.
- the fluid chambers may collect and/or store fluid from the fluid processing system, and each fluid chamber may have a port that allows fluid to enter or exit each of the fluid chambers.
- Each of the pressure chambers may have a chamber volume and may be fluidly connectable with a fluid flow line within the fluid processing system, such that a pressure/fluid within the flow line compresses the chamber volume when fluidly connected.
- each of the pressure chambers may have a tube with an open end and a closed end. The tube(s) may define the chamber volume, and the chamber volume may be in fluid communication with the fluid flow line via the open end. The inner diameter of the tube may be dependent on a target pressure range for the pressure chamber.
- the housing may include a first and second sheet of flexible material (e.g. PVC) that are secured together (e.g., via RF welding) to form the plurality of fluid chambers and plurality of pressure chambers.
- the housing may also include reference marks on each of the fluid chambers. The reference marks may provide an indication of a fluid level in each of the fluid chambers.
- the fluid level in each of the fluid chambers may be related to a volume of fluid within the fluid chamber.
- One or more of the fluid chambers may be V-shaped.
- FIG. 1 schematically shows a cross-sectional view of a fluid bag in accordance with embodiments of the present invention.
- FIG. 2 schematically shows a volume and pressure measurement system with the fluid bag of FIG. 1 installed, in accordance with embodiments of the present invention.
- FIG. 3 schematically shows an exemplary disposable set containing a fluid container similar to that shown in FIG. 1 and for use with the volume and pressure measurement system shown in FIG. 2 , in accordance with embodiments of the present invention.
- FIG. 4 schematically shows an exemplary layout of a blood processing system for use with the volume and pressure measurement system shown in FIG. 2 , in accordance with embodiments of the present invention.
- a volume and pressure measurement system is able to measure a volume of fluid within a fluid container by taking an image of the fluid container. Additionally, various embodiments are able to measure a pressure within a pressure chamber by similarly taking an image of the pressure chamber. The pressure may correspond to a pressure within a fluid line of a fluid processing system to which the fluid container is connected.
- FIG. 1 schematically shows a cross section of a fluid container 100 for use with the volume and pressure measurement system, in accordance with embodiments of the present invention.
- the fluid container 100 has a housing 110 that defines the structure of the container 100 .
- the housing 110 may be constructed from two sheets of PVC material that are secured to one another (e.g., via RF welding) to form the container.
- the container may be constructed in a manner similar to a disposable fluid or blood bag used with an apheresis and other blood processing system.
- the container 100 may contain a number of fluid chambers/bags 120 A-D.
- Each of these chambers/bags 120 A-D may have at least one port 130 A-D (e.g., an inlet, an outlet, or an inlet and an outlet) to allow fluid to be collected within or withdrawn from the chamber 120 A-D (discussed in greater detail below).
- each of the ports 130 A-D may be fluidly connected to a fluid processing system.
- the ports 130 A-D may be fluidly connected to a blood component separation device within the blood processing system and/or to one or more fluid transfer lines.
- some of the fluid chambers 120 A-D may be used to collect processed fluids/blood components (e.g., plasma, platelets, etc.).
- one or more of the fluid chambers 120 A-D may be V-shaped so that the fluid level within the chamber 120 A-D increases more significantly when only small volume of fluid is within the chamber 120 A-D (e.g., such that a small increase in fluid volume significantly increases the height of the fluid level).
- some embodiments of the fluid container 100 may also contain one or more pressure chambers 140 A-C that, as discussed in greater detail below, may be used to measure the pressure within one or more of the fluid lines of the fluid processing system.
- each of the pressure chambers 140 A-C may have a port 150 A-C that, in turn, can be fluidly connected to the fluid processing system.
- each port 150 A-C of the pressure chambers 140 A-C may be fluidly connected (e.g., via a section of tubing and a connector) to a fluid line within the fluid processing device.
- the pressure chambers 140 A-C may be used to measure the pressure within the lines of the fluid processing system (e.g. the pressure within the line to which the individual pressure chamber 140 A-C is fluidly connected).
- the pressure chambers 140 A-C may contain a volume of air that compresses as the pressure within the fluidly connected line increases, and expands as the pressure decreases.
- a small volume of fluid will flow into the line connecting the pressure chamber 140 A-C and the fluid processing device and into the pressure chamber 140 A-C.
- the fluid level within the pressure chamber 140 A-C e.g., from the small volume of fluid that flows in
- the volume and pressure measurement system may then monitor the fluid level within each pressure chamber 140 A-C to determine the pressure within the fluid line (discussed in greater detail below).
- the pressure chamber 140 A-C may include a section of semi-rigid tubing (not shown) that extends the length of the pressure chamber 140 A-C and defines the volume of air (e.g., the internal diameter of the tubing may define the volume of air).
- the tubing may be RF welded within the pressure chamber 140 A-C and may have a closed/sealed top end and an open opposing/bottom end (e.g., to allow the fluid to enter the pressure chamber 140 A-C).
- the open end of the tubing may form the port 150 A-C that is fluidly connected to the fluid processing system.
- the port 150 A-C may be connected/secured to the open end of the tubing.
- the required pressure range for one pressure chamber 140 A-C may be greater/less than the required pressure range for another pressure chamber 140 A-C.
- the size of the pressure chamber 140 A-C and/or the semi-rigid tubing may be adjusted up or down. For example, if the required pressure range/scale is relatively large (e.g., the pressure within the fluid line is relatively high), tubing having a larger inner diameter may be used (to create a larger volume of air).
- tubing having a smaller inner diameter may be used.
- the length of the tubing e.g., the height of the pressure chamber 140 A-C
- sensitivity e.g., the length of the semi-rigid tube may be increased to increase the pressure range or decreased to reduce the pressure range.
- some embodiments of the fluid container may include perforations that separate each of the fluid chambers 120 A-D from one another, and from each of the pressure chambers 140 A-C. This allows the user to remove individual fluid chambers 120 A-D as needed (e.g., after fluid processing). It should also be noted that, although FIG.
- FIG. 1 shows a fluid container 100 having three pressure chambers 140 A-C and four fluid chambers 120 A-D
- other embodiments may have more or less pressure chambers 140 A-C and fluid chambers 120 A-C (e.g., depending on the application/fluid processing procedure).
- the fluid container 100 have less than three (e.g., from 0-2) or more than three (4 or more) pressure chambers 140 A-C.
- the fluid container 100 may have less than four fluid chambers 120 A-D (e.g., from 0-3) or more than four fluid chambers 120 A-D (5 or more).
- the fluid container 100 can be used in conjunction with a fluid volume and pressure measurement system 200 that is capable of determining the volume of fluid within each fluid chamber 120 A-D and the pressure within the pressure chambers 140 A-C (if the container 100 includes pressure chambers 140 A-C).
- the measurement system 200 may include a housing 210 in which the components of the system 200 may be located.
- the housing 200 may also include a measurement area 220 in which the container 100 may be placed during measurement and a cover 230 that holds the container 100 in place.
- the cover 230 may be secured to the housing 210 via a hinge to allow the cover 230 to open and close and the container 100 to be placed in the measurement area 220 .
- the cover 230 may be stationary with respect to the housing 210 and may include a slot 235 through which the container 100 may be inserted into the measurement area 220 .
- the wall 212 of the housing 210 at the measurement area 220 may be clear/transparent and the cover 230 may be opaque.
- the system 200 includes an imaging unit 240 that takes images of the container 100 through the clear wall 212 of the housing 210 when the container 100 is within the measurement area 220 .
- the imaging unit 240 may include a solid state imager 242 with one or more cameras aimed through the clear wall 212 into the measurement area 220 .
- the imaging unit 240 may include a light source 244 that illuminates the container 100 to allow the imaging unit 240 to image the container 100 .
- the light source 244 may include one or more light emitting diodes (LEDs) that illuminate the container 100 .
- the light source 244 may include an array of LEDS having varying colors (e.g., red, green, blue, etc.) to allow the imaging system 200 to illuminate the container 100 in a number of colors.
- the imaging unit e.g., the solid state imager 242 /camera
- the imaging unit may have a wide angle lens.
- the imaging unit 240 may image the container 100 and send the images and/or image data to a controller 250 , which determines the fluid volume and/or pressure based on the image/image data.
- the controller 250 may determine the volume of fluid within each of the fluid chambers 120 A-D based on the fluid level within the respective fluid chamber 120 A-D.
- the container 100 may include a series of reference marks/graduations.
- the container 100 may include one set of reference marks for the entire container 100 (e.g., all fluid chambers 120 A-D may utilize the same set of marks), or each fluid chamber 120 A-D may have their own set of reference marks.
- the reference marks also allow the system 200 to automatically adjust and eliminate sensor (e.g., solid state imager 242 ) calibration.
- the system 200 may measure the pressure by monitoring the fluid level within the pressure chamber 140 A-C.
- each of the pressure chambers 140 -C may be fluidly connected to a fluid line in a fluid processing system.
- a portion of fluid flowing through the fluid line connected to the pressure chamber 140 A-C will flow into the pressure chamber 140 A-C and will compress the volume of air within the pressure chamber 140 A-C.
- the amount of compression (and, therefore, the fluid level within the pressure chamber 140 A-C) is directly related to the pressure within the fluid line. For example, if the pressure within the fluid line increases, the fluid will further compress the volume of air in the pressure chamber 140 A-C and the fluid level will rise.
- the controller 150 may then determine the pressure of the fluid within the fluid line based on the fluid level within the pressure chamber 140 A-C.
- the pressure chambers 140 A-C may include reference marks/graduations to improve the accuracy of the level measurement.
- some embodiments of the present invention may utilize look-up tables that correlate the imaged fluid level (e.g., the level of the fluid within the fluid chambers 120 A-D and/or the level of fluid within the pressure chambers 140 A-C) with a fluid volume in the fluid chamber 120 A-D or pressure within the fluid line.
- the system 200 e.g., the controller 250
- the system 200 may determine the level of fluid for a given chamber (e.g., using the reference marks) and then refer to the look-up table to find the fluid volume or pressure that correlates to the imaged fluid level.
- the system 200 may display the volume and/or pressure on a display on the system. Additionally or alternatively, the system 200 can send the volume and pressure information to the fluid processing system for display and/or use by the fluid processing system. In some embodiments the system 200 (or the fluid processing system) may monitor the fluid volume and/or pressure to determine if the fluid volume reaches a target or threshold level. For example, if the fluid level within one of the fluid chambers 120 A-D reaches a target level (e.g., indicating that a target volume of fluid has been collected in the fluid chamber 120 A-D), the system 200 or the fluid processing system may stop or otherwise alter the fluid processing procedure.
- a target or threshold level e.g., indicating that a target volume of fluid has been collected in the fluid chamber 120 A-D
- the system 200 may initiate an alarm or adjust the fluid flow within the fluid line.
- a threshold level e.g., indicating that a pressure in one of the fluid lines is too high or too low
- FIG. 3 schematically shows a disposable set for a blood processing device utilizing a fluid container 100 and system 200 similar to that described above. It is important to note that, unlike the container 100 shown in FIG. 1 (which has three pressure chambers 140 A-C and four fluid chambers 120 A-D), the container 100 shown in FIG. 3 has five fluid chambers 120 A-E and no pressure chambers 140 A-C. Also, although FIG. 3 shows the fluid container 100 being used for blood processing, the container 100 can be used for any number of liquid processing procedures.
- whole blood may be drawn from a source (e.g., a patient, a blood storage bag, etc.) using a donor/draw pump 330 , and through a draw line 310 .
- a portion of the drawn whole blood may flow into the centrifuge bowl 320 and a portion of the whole blood may be diverted to an in-buffer/draw chamber 120 A.
- all of the whole blood may be diverted to the in-buffer/draw chamber 120 A and later drawn from the in-buffer/draw chamber 120 A and into the bowl 320 .
- an anticoagulant pump 340 may draw anticoagulant through an anticoagulant line 342 and filter 344 from an anticoagulant source 345 .
- the anticoagulant may mix with the drawn whole blood prior to reaching the in-buffer/draw chamber 120 A and/or the bowl 320 .
- the air within the bowl 320 may be displaced via an outlet 322 and line 370 to an air chamber 120 C of the container 100 .
- a bowl pump 350 may begin to draw anticoagulated whole blood from the in-buffer/draw chamber 120 A via line 352 .
- valves (not shown) may be opened to allow the anticoagulated whole blood to flow into line 352 .
- the bowl pump 350 may draw the anticoagulated whole blood from the in-buffer/draw chamber 120 A at a rate slower than that of the donor pump 330 .
- the bowl pump 350 may draw at a rate of 60 mL/min as compared to the donor pump's rate of 120 mL/min.
- the bowl 320 will continue to fill until an optical system 360 detects the presence of a plasma/cell interface created by the separation of the whole blood within the bowl 320 .
- the whole blood will continue to separate.
- the centrifugal forces cause the heavier cellular components of the blood to sediment from the lighter plasma component of the blood.
- the red blood cells are by far the most numerous of the cellular components of blood and the most dense, resulting in a layer of concentrated red blood cells at the outermost diameter of the bowl 320 .
- the other cellular components of blood begin to become apparent.
- These cellular components are primarily platelets, leukocytes and peripheral hematopoietic progenitor stem cells. These cells may have a range of densities between that of the red blood cells and plasma. Therefore they tend to sediment in a layer between the red blood cell layer and plasma layer. As this layer grows, it is visually apparent as a solid white layer which is known as a buffy coat.
- the red blood cells will continue to sediment to the outermost diameter, and the intermediate cells of the buffy coat will continue to accumulate at the red blood cell/plasma interface, and the plasma interface will move inward towards the center of the bowl 320 .
- the plasma will exit the bowl 320 via the outlet 322 .
- some of the plasma may pass through line 370 and into an out buffer chamber 120 E of the container 100 and some of the plasma may be sequestered within the plasma chamber 120 B of the container 100 .
- the operator or the control system of the blood processing system can open valve C 3 to allow some of the plasma exiting the bowl 320 to enter line 372 and flow into the plasma chamber 120 B.
- the sequestered plasma in the plasma chamber 120 B may be used during a surge elutriation procedure to remove the platelets from the bowl 320 .
- the bowl 320 may be a continuous flow bowl that allows the continuous processing of whole blood without the need to intermittently stop.
- various embodiments of the present invention also extract red blood cells from the bowl 320 as additional whole blood is introduced (e.g., while simultaneously extracting plasma).
- a red blood cell pump 380 can draw red blood cells out of an additional output 324 (e.g., a first blood component/red blood cell outlet) on the bowl 320 .
- an additional output 324 e.g., a first blood component/red blood cell outlet
- the optical system 360 will monitor the location of the plasma/cell interface and may control the flow rate of the red blood cell pump 380 to adjust the location of the interface as necessary (e.g., it will speed up the pump 380 if the sensor output decreases and slow down the pump 380 if the sensor output increases).
- the system 300 will stop the draw step and begin to return some of the blood components (e.g., red blood cells and plasma) that have been collected in the out buffer/return chamber 120 E.
- the system 300 may energize a return pump 390 , which will draw (e.g., at 120 mL/min) the plasma and red blood cells within the out buffer/return chamber 120 E through line 395 , and back to the source (e.g., back to the patient).
- This return phase will continue until a predetermined volume of red blood cells and plasma are returned to the subject, for example, 80 mL.
- the system 300 may then alternate the draw and return phases until the procedure is complete.
- a compensation fluid such as saline may be returned to the patient along with the blood components within the out buffer/return chamber 120 E.
- the return pump 390 may draw the compensation fluid from a container 440 and through a compensation line 445 .
- anticoagulated whole blood may be continuously drawn from the in-buffer/draw chamber 120 A and into the bowl 320 , even during the return phase.
- this can be accomplished by first drawing a bolus volume of whole blood from the subject, collecting the bolus volume of whole blood within the in-buffer/draw chamber 120 A, and drawing the whole blood from the in-buffer/draw chamber 120 A at a slower rate than the draw and return steps (e.g., the bowl pump 350 draws the anticoagulated whole blood at 60 mL/min and the donor pump 330 draws the whole blood from the subject and returns the red blood cells and plasma to the subject at 120 mL/min). Therefore, the in-buffer/draw chamber 120 A always has a sufficient volume of anticoagulated whole blood from which the bowl pump 350 can draw.
- the whole blood processing may continue until a desired volume of platelets has accumulated within the bowl 320 .
- the system 300 may then perform a surge elutriation process using the sequestered plasma in order to extract the highly concentrated platelet product.
- the bowl pump 350 can draw the plasma within the plasma chamber 120 B through a plasma recirculation line 354 and into the bowl 320 (e.g., via the inlet 326 ).
- the flow rate of plasma is gradually increased.
- the effluent plasma passes through a line sensor 374 (located on line 370 ) that monitors the fluid exiting the bowl 320 .
- the drag force created by the plasma flow overcomes the centrifugal force caused by the bowl rotation, and the platelets are carried away from the buffy coat in the flowing plasma.
- the line sensor 374 may then detect the presence of cells (e.g., as the fluid exiting the bowl 320 changes from plasma to platelets), and the system 300 (or the user) can close valve C 3 and open valve C 5 to allow the platelets to flow into the platelet line 376 and into the platelet chamber 120 D of the container 100 .
- the system 300 may stop the bowl 320 and return the contents of the bowl 320 to the donor. For example, the system 300 may turn on the red blood cell pump 380 to draw the contents of the bowl 320 into the out buffer/return chamber 120 E (via line 385 ). The return pump 390 may then draw the contents of the out buffer/return chamber 120 E through line 395 , and return the components via the return line 397 .
- platelet additive solution may be added to the platelets within the platelet chamber 120 D (from platelet additive solution container 430 and via line 435 and valve C 6 ), and the platelets may be filtered using a platelet filter 410 and transferred to a filtered platelet container 420 via line 415 .
- the vision system 200 can monitor the fluid levels in each of the chambers 120 A-E in manner similar to that described above. For example, as the plasma enters or is drawn from the plasma chamber 120 B, platelets enter/are drawn from the platelets chamber 120 D, and when plasma and/or red blood cells enter/are drawn from the out buffer/return chamber 120 E, the vision system 200 can monitor the volumes collected and/or remaining in each of the chambers 120 A-E. Additionally, the vision system 200 may monitor the level of whole blood within the in-buffer/draw chamber 120 A to ensure that the in-buffer/draw chamber 120 A contains sufficient whole blood to continuously supply the bowl 320 with whole blood. The blood processing system 300 may then use this information to adjust/alter/control the blood processing procedure. For example, the blood processing system 300 can control the pumps, centrifuge bowl 320 , valves, or other components of the system based upon the volumes.
- FIG. 3 illustrates a blood processing system 300 utilizing a container 100 without pressure chambers
- other embodiments may include pressure chambers to allow the vision system 200 and/or the blood processing system to measure the pressures within one or more of the fluid lines.
- FIG. 4 shows a layout of the blood processing system 300 with a container 100 with five fluid chambers 120 A-E (like the container shown in FIG. 3 ), and three pressure chambers 140 A-C. It should be noted that the operation of the blood processing system 300 is similar to that shown in FIG. 3 (including the roles of each of the fluid chambers 120 A-E) and described above.
- an anticoagulant pressure chamber 140 A may connect to the anticoagulant line 342 at pressure connection 346 .
- a draw pressure chamber 140 B may connect to the draw line 310 at pressure connection 315
- a seal pressure chamber 140 C may connect to line 370 extending from outlet 322 at pressure connection 375 (see FIG. 3 ).
- FIG. 4 does not include a pressure chamber connected to the red blood cell pressure connection 387 (e.g., it uses a standard pressure transducer to measure the pressure within the red blood cell line 385 )
- other embodiments can include a fourth pressure chamber that is connected to the red blood cell line 385 at pressure connection 387 .
- a portion of the fluid in each of the fluid lines (e.g., the anticoagulant line 342 , the draw line 310 , and line 370 ) will enter the pressure chambers 140 A-C and cause the volume of air within each of the chambers 140 A-C to compress. Then, as the pressure within each of the lines 310 / 341 / 370 changes, the pressure change will be translated to the pressure chambers 140 A-C, causing the volume of air in the chambers 140 A-C to compress further if the pressure increases and/or expand if the pressure decreases (e.g., the fluid level within the chambers 140 A-C will move up and/or down).
- the vision system 200 may then monitor the fluid level within each of the chambers 140 A-C and determine the respective pressure within the connected line (e.g., within lines 342 , 310 and 370 ). The system 200 may then send this pressure information to the blood processing system 300 (e.g., to a controller within the blood processing system 300 ) along with the fluid volume information determined from the fluid chambers 120 A-E. The blood processing system 300 may then adjust/alter/control the blood processing procedure. For example, the blood processing system 300 can control the pumps, centrifuge bowl 320 , valves, or other components of the system based upon the measured pressures (and/or volumes).
- the blood processing method discussed above draws whole blood from and returns the contents of the bowl to a donor
- some embodiments may not draw from and/or return to a donor. Rather, in some embodiments, the whole blood may be drawn from a whole blood storage container, and the contents of the bowl 320 may be returned to the whole blood storage container (or a different blood storage container).
- embodiments of the present invention provide additional benefits over prior art containers and pressure/volume measurement system.
- the container 100 includes individual chambers 120 A-D for a number of fluids collected and used during fluid processing, the container 100 may be installed as a single piece as opposed to several separate containers. This, in turn, simplifies installation/loading and reduces installation/loading time.
- embodiments of the present invention are able to further reduce the complexity of the fluid processing system (e.g., the blood processing system 300 ), system calibration, and cost, while increasing reliability.
Abstract
Description
- This patent application claims priority from U.S. Provisional Patent Application No. 62/246,795, filed Oct. 27, 2015, entitled “System and Method for Measuring Volume and Pressure,” assigned attorney docket number 1611/C42, and naming Gary Stacey as inventor, the disclosure of which is incorporated herein, in its entirety by reference.
- present invention relates to measuring fluid volumes and pressures, and more particularly to an imaging system for measuring fluid volumes and pressures.
- During various fluid processing procedures, such as apheresis procedures, it is important to measure both the volume of fluids collected/processed, as well as the various pressures throughout the fluid processing system. It is common to measure the volume of fluid in a disposable bag or bottle using a strain gauge load cell. This technique is effective but has several problems. For example, if the load cell or the bag/bottle hanging from the load cell are bumped, the measurement may be impacted, causing measurement errors. Additionally, if the bump (or other contact) is significant enough to create an over stress on the load cell, the load cell may permanently shift from the zero position, which, in turn, disables the device.
- Furthermore, if multiple containers need to weighed, system set up and loading may become labor intensive, as the correct bag/container needs to be hung on the appropriate load cell to avoid errors in measurement and fluid processing. Also, the tubes connected to the bags/containers need to be positioned in a way that they do not drag on surfaces causing incorrect measurements. Additionally, because each container needs a separate load cell, the cost increases significantly as additional containers are added to the system.
- With respect to pressure measurement, current systems commonly use pressure transducers isolated by a filter to measure pressures within fluid lines. The filter provides a sterile barrier and prevents fluid and contaminates from touching the transducer. However, any leakage in the filter/transducer assembly (e.g., between the output of the filter and the transducer) will allow the fluid to contact the filter material which negatively impacts the accuracy of the pressure measurement and, effectively, disables the pressure measurement system. Additionally, in a manner similar to the volume measurement, when multiple pressure measurements are needed, system set-up and loading may become labor intensive, and the cost of the system increases significantly (e.g., because each pressure measurement will require a separate transducer).
- In accordance with one embodiment of the invention, a volume measurement system for a fluid processing device includes a fluid container, an imaging unit and a controller. The fluid container may include a fluid container housing that defines the structure of the fluid container, and a plurality of fluid chambers within the fluid container housing. The fluid chambers may be configured to collect and/or store fluid from the fluid processing device, and each of the fluid chambers may have a port that allows fluid to enter or exit the fluid chamber. The imaging unit may take images of the fluid chambers and may be positioned to view a level of fluid in each of the fluid chambers. The controller may be in communication with the imaging unit and may determine a volume of fluid within each of the fluid chambers based upon the viewed level of fluid in each fluid chamber.
- In some embodiments, the system may also include a housing (e.g., a system housing) that defines the structure of the volume measurement system. The imaging unit and controller may be located within the housing, and at least a portion of a first wall of the system housing may be transparent to allow the imaging unit to view the fluid container and take the images. The system/housing may include an opaque cover that holds the fluid container in place when closed. For example, the fluid container may be located between the opaque cover and the first wall when installed in the volume measurement system.
- The imaging unit may include a camera that takes the images of the plurality of fluid chambers, and a light source that is directed at the fluid container. The light source may illuminate the fluid chambers to allow the camera to take the images of the fluid chambers. The imaging unit may be a solid state imager and/or include a wide angle lens. The imaging unit and/or controller may be part of the fluid processing device.
- The fluid container may also include a plurality of pressure chambers within the housing. Each of the pressure chambers may have a chamber volume that is fluidly connectable with a fluid flow line within the fluid processing device. The fluid/pressure within the flow line may compress the chamber volume when fluidly connected. Each of the pressure chambers may include a tube having an open end and a closed end. The tube may define the chamber volume, and the chamber volume may be fluidly connectable with the fluid flow line via the open end. The inner diameter of the tube may be dependent on a target pressure range for the pressure chamber. Additionally, the imaging unit may take images of the plurality of pressure chambers, and the controller may determine a pressure level within the pressure chambers based on the image of the pressure chambers. The controller may use a look-up table to determine the pressure level and/or volume of fluid.
- The housing of the fluid container may include a first and second sheet of flexible material that are secured together to form the fluid chambers and/or the pressure chambers. For example the first and second sheets of material may be PVC and RF welded together. Additionally or alternatively, the housing may have a plurality of reference marks on each of the fluid chambers that provide an indication of a fluid level in each of the fluid chambers. In such embodiments, the fluid level may be related to the volume of fluid within the fluid chamber. The fluid container may have perforations that allow the fluid chambers and/or pressure chambers to be separated from one another. One or more of the fluid chambers may be V-shaped.
- In accordance with additional embodiments, a method of measuring a volume of fluid within a fluid container may include providing a fluid container having a plurality of fluid chambers and fluidly connecting each of the fluid chambers to a fluid line on the fluid processing system via a port on the fluid chambers. The fluid container may also include a fluid container housing defining the structure of the fluid container. The fluid chambers may be within the housing and configured to collect and/or store fluid from the fluid processing system. The ports may allow fluid to enter or exit each of the fluid chambers. The method may also include installing the fluid container into a volume measurement device. The volume measurement device may have an imaging unit that takes images of the fluid chambers and is positioned to view a level of fluid in each of the fluid chambers. The method may then image each of the fluid chambers using the imaging unit, and determine, using a controller in communication with the imaging unit, a volume of fluid within each of the fluid chambers based upon the images of the fluid chambers.
- The volume measurement device may include a system housing defining the structure of the volume measurement device. The imaging unit and controller may be located within the housing, and at least a portion of a first wall of the system housing may be clear to allow the imaging unit to view the fluid container and take the images. The system housing may also have an opaque cover, and installing the fluid container into the volume measurement device may include closing the opaque cover over the fluid container to secure the fluid container within the volume measurement device.
- The imaging unit may include (1) a camera configured to take the images of the fluid chambers, and (2) a light source directed at the fluid container and configured to illuminate the fluid chambers to allow the camera to take the images of the fluid chambers. The imaging unit may be a solid state imager and/or include a wide angle lens. The volume measurement device may be part of the fluid processing system.
- In some embodiments, the fluid container may include a plurality of pressure chambers within the housing and having chamber volumes. In such embodiments, the method may include fluidly connecting each of the pressure chambers to a fluid flow line within the fluid processing system, such that a pressure/fluid within the flow line compresses the chamber volume. Additionally, the method may image each of the pressure chambers using the imaging unit, and determine, using the controller, a pressure level within each of the pressure chambers based on the image of the pressure chamber.
- Each of the pressure chambers may include a tube with an open end and a closed end. The tube may define the chamber volume, and the chamber volume may be in fluid communication with the fluid flow line via the open end. The inner diameter of the tube may be dependent on a target pressure range for the pressure chamber. The controller may use a look-up table to determine the pressure level within each of the pressure chambers.
- The fluid container housing may include a first sheet and second sheet of flexible material (e.g., PVC) that are secured together (e.g., via RF welding) to form the plurality of fluid chambers and/or pressure chambers. The housing may have plurality of reference marks on each of the fluid chambers that provide an indication of the fluid level in each of the fluid chambers. The fluid level may be related to a volume of fluid within the fluid chamber.
- In accordance with still further embodiments, a fluid container for a fluid processing system includes a housing defining the structure of the fluid container, a plurality of fluid chambers within the housing, and a plurality of pressure chambers within the housing. The fluid chambers may collect and/or store fluid from the fluid processing system, and each fluid chamber may have a port that allows fluid to enter or exit each of the fluid chambers. Each of the pressure chambers may have a chamber volume and may be fluidly connectable with a fluid flow line within the fluid processing system, such that a pressure/fluid within the flow line compresses the chamber volume when fluidly connected. Additionally or alternatively, each of the pressure chambers may have a tube with an open end and a closed end. The tube(s) may define the chamber volume, and the chamber volume may be in fluid communication with the fluid flow line via the open end. The inner diameter of the tube may be dependent on a target pressure range for the pressure chamber.
- The housing may include a first and second sheet of flexible material (e.g. PVC) that are secured together (e.g., via RF welding) to form the plurality of fluid chambers and plurality of pressure chambers. The housing may also include reference marks on each of the fluid chambers. The reference marks may provide an indication of a fluid level in each of the fluid chambers. The fluid level in each of the fluid chambers may be related to a volume of fluid within the fluid chamber. One or more of the fluid chambers may be V-shaped.
- The foregoing features of embodiments will be more readily understood by reference to the following detailed description, taken with reference to the accompanying drawings, in which:
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FIG. 1 schematically shows a cross-sectional view of a fluid bag in accordance with embodiments of the present invention. -
FIG. 2 schematically shows a volume and pressure measurement system with the fluid bag ofFIG. 1 installed, in accordance with embodiments of the present invention. -
FIG. 3 schematically shows an exemplary disposable set containing a fluid container similar to that shown inFIG. 1 and for use with the volume and pressure measurement system shown inFIG. 2 , in accordance with embodiments of the present invention. -
FIG. 4 schematically shows an exemplary layout of a blood processing system for use with the volume and pressure measurement system shown inFIG. 2 , in accordance with embodiments of the present invention. - In illustrative embodiments, a volume and pressure measurement system is able to measure a volume of fluid within a fluid container by taking an image of the fluid container. Additionally, various embodiments are able to measure a pressure within a pressure chamber by similarly taking an image of the pressure chamber. The pressure may correspond to a pressure within a fluid line of a fluid processing system to which the fluid container is connected.
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FIG. 1 schematically shows a cross section of afluid container 100 for use with the volume and pressure measurement system, in accordance with embodiments of the present invention. Thefluid container 100 has ahousing 110 that defines the structure of thecontainer 100. Thehousing 110 may be constructed from two sheets of PVC material that are secured to one another (e.g., via RF welding) to form the container. In this manner, the container may be constructed in a manner similar to a disposable fluid or blood bag used with an apheresis and other blood processing system. - To allow the
container 100 to collect and/or store more than one type of fluid, thecontainer 100 may contain a number of fluid chambers/bags 120A-D. Each of these chambers/bags 120A-D may have at least oneport 130A-D (e.g., an inlet, an outlet, or an inlet and an outlet) to allow fluid to be collected within or withdrawn from thechamber 120A-D (discussed in greater detail below). In use, each of theports 130A-D may be fluidly connected to a fluid processing system. For example, if the fluid processing system is a blood processing system (e.g., an apheresis system), theports 130A-D may be fluidly connected to a blood component separation device within the blood processing system and/or to one or more fluid transfer lines. As discussed in greater detail below, when fluidly connected in this manner, some of thefluid chambers 120A-D may be used to collect processed fluids/blood components (e.g., plasma, platelets, etc.). To improve the low volume accuracy, one or more of thefluid chambers 120A-D may be V-shaped so that the fluid level within thechamber 120A-D increases more significantly when only small volume of fluid is within thechamber 120A-D (e.g., such that a small increase in fluid volume significantly increases the height of the fluid level). - In addition to the
fluid chambers 120A-D, as shown inFIG. 1 , some embodiments of thefluid container 100 may also contain one ormore pressure chambers 140A-C that, as discussed in greater detail below, may be used to measure the pressure within one or more of the fluid lines of the fluid processing system. Like the fluid chambers/bags 120A-D, each of thepressure chambers 140A-C may have aport 150A-C that, in turn, can be fluidly connected to the fluid processing system. For example, eachport 150A-C of thepressure chambers 140A-C may be fluidly connected (e.g., via a section of tubing and a connector) to a fluid line within the fluid processing device. - As noted above, the
pressure chambers 140A-C may be used to measure the pressure within the lines of the fluid processing system (e.g. the pressure within the line to which theindividual pressure chamber 140A-C is fluidly connected). To that end, thepressure chambers 140A-C may contain a volume of air that compresses as the pressure within the fluidly connected line increases, and expands as the pressure decreases. For example, as fluid flows through the lines of the fluid processing system, a small volume of fluid will flow into the line connecting thepressure chamber 140A-C and the fluid processing device and into thepressure chamber 140A-C. As the pressure within the fluid line increases and decreases, the fluid level within thepressure chamber 140A-C (e.g., from the small volume of fluid that flows in) will similarly go up and down. The volume and pressure measurement system may then monitor the fluid level within eachpressure chamber 140A-C to determine the pressure within the fluid line (discussed in greater detail below). - It should be noted that, depending on the material used to form the
container 100, thecontainer 100 material may be too pliable to allow for accurate pressure measurement (e.g., it may deform as the pressure increases). Therefore, in some embodiments, thepressure chamber 140A-C may include a section of semi-rigid tubing (not shown) that extends the length of thepressure chamber 140A-C and defines the volume of air (e.g., the internal diameter of the tubing may define the volume of air). In such embodiments, the tubing may be RF welded within thepressure chamber 140A-C and may have a closed/sealed top end and an open opposing/bottom end (e.g., to allow the fluid to enter thepressure chamber 140A-C). The open end of the tubing may form theport 150A-C that is fluidly connected to the fluid processing system. Alternatively, theport 150A-C may be connected/secured to the open end of the tubing. - In some embodiments, it may be necessary to measure pressures across a variety of ranges (e.g., the required pressure range for one
pressure chamber 140A-C may be greater/less than the required pressure range for anotherpressure chamber 140A-C). To accommodate varying pressure ranges, the size of thepressure chamber 140A-C and/or the semi-rigid tubing may be adjusted up or down. For example, if the required pressure range/scale is relatively large (e.g., the pressure within the fluid line is relatively high), tubing having a larger inner diameter may be used (to create a larger volume of air). Conversely, if the pressure range/scale is relatively low (e.g., the pressure within the fluid line is low), tubing having a smaller inner diameter (to create a smaller volume of air) may be used. Additionally, the length of the tubing (e.g., the height of thepressure chamber 140A-C) may be adjusted to get the desired pressure level and sensitivity (e.g., the length of the semi-rigid tube may be increased to increase the pressure range or decreased to reduce the pressure range). - In some applications, it may be necessary or desirable to separate the
individual fluid chambers 120A-D from one another and from thepressure chambers 140A-C (and separate thepressure chambers 140A-C from one another). To that end, some embodiments of the fluid container may include perforations that separate each of thefluid chambers 120A-D from one another, and from each of thepressure chambers 140A-C. This allows the user to removeindividual fluid chambers 120A-D as needed (e.g., after fluid processing). It should also be noted that, althoughFIG. 1 shows afluid container 100 having threepressure chambers 140A-C and fourfluid chambers 120A-D, other embodiments may have more orless pressure chambers 140A-C andfluid chambers 120A-C (e.g., depending on the application/fluid processing procedure). For example, thefluid container 100 have less than three (e.g., from 0-2) or more than three (4 or more)pressure chambers 140A-C. Similarly, thefluid container 100 may have less than fourfluid chambers 120A-D (e.g., from 0-3) or more than fourfluid chambers 120A-D (5 or more). - As noted above, the
fluid container 100 can be used in conjunction with a fluid volume andpressure measurement system 200 that is capable of determining the volume of fluid within eachfluid chamber 120A-D and the pressure within thepressure chambers 140A-C (if thecontainer 100 includespressure chambers 140A-C). As shown inFIG. 2 , themeasurement system 200 may include ahousing 210 in which the components of thesystem 200 may be located. Thehousing 200 may also include ameasurement area 220 in which thecontainer 100 may be placed during measurement and acover 230 that holds thecontainer 100 in place. Thecover 230 may be secured to thehousing 210 via a hinge to allow thecover 230 to open and close and thecontainer 100 to be placed in themeasurement area 220. Alternatively, thecover 230 may be stationary with respect to thehousing 210 and may include aslot 235 through which thecontainer 100 may be inserted into themeasurement area 220. As discussed in greater detail below, thewall 212 of thehousing 210 at themeasurement area 220 may be clear/transparent and thecover 230 may be opaque. - In order to measure the volumes and pressures, the
system 200 includes animaging unit 240 that takes images of thecontainer 100 through theclear wall 212 of thehousing 210 when thecontainer 100 is within themeasurement area 220. To that end, theimaging unit 240 may include asolid state imager 242 with one or more cameras aimed through theclear wall 212 into themeasurement area 220. Additionally, in some embodiments, theimaging unit 240 may include alight source 244 that illuminates thecontainer 100 to allow theimaging unit 240 to image thecontainer 100. - The
light source 244 may include one or more light emitting diodes (LEDs) that illuminate thecontainer 100. In some embodiments, thelight source 244 may include an array of LEDS having varying colors (e.g., red, green, blue, etc.) to allow theimaging system 200 to illuminate thecontainer 100 in a number of colors. In order to minimize the setback distance (e.g., the distance between thecontainer 100 and the imaging unit 240) and the size of thesystem 200, the imaging unit (e.g., thesolid state imager 242/camera) may have a wide angle lens. - During use, the
imaging unit 240 may image thecontainer 100 and send the images and/or image data to acontroller 250, which determines the fluid volume and/or pressure based on the image/image data. For example, with respect to the fluid volume, thecontroller 250 may determine the volume of fluid within each of thefluid chambers 120A-D based on the fluid level within therespective fluid chamber 120A-D. To aid in determining the fluid level within each of thefluid chambers 120A-D, thecontainer 100 may include a series of reference marks/graduations. For example, thecontainer 100 may include one set of reference marks for the entire container 100 (e.g., allfluid chambers 120A-D may utilize the same set of marks), or eachfluid chamber 120A-D may have their own set of reference marks. In addition to providing a more accurate measure of the fluid level within thefluid chambers 120A-D, the reference marks also allow thesystem 200 to automatically adjust and eliminate sensor (e.g., solid state imager 242) calibration. - With respect to the
pressure chambers 140A-C, thesystem 200 may measure the pressure by monitoring the fluid level within thepressure chamber 140A-C. As mentioned above, each of the pressure chambers 140-C may be fluidly connected to a fluid line in a fluid processing system. In such a configuration, a portion of fluid flowing through the fluid line connected to thepressure chamber 140A-C will flow into thepressure chamber 140A-C and will compress the volume of air within thepressure chamber 140A-C. The amount of compression (and, therefore, the fluid level within thepressure chamber 140A-C) is directly related to the pressure within the fluid line. For example, if the pressure within the fluid line increases, the fluid will further compress the volume of air in thepressure chamber 140A-C and the fluid level will rise. Conversely, if the pressure within the fluid line drops, the amount of compression will decrease (e.g., the volume of air will expand) and the fluid level will drop. Like with thefluid chambers 120A-D, the controller 150 may then determine the pressure of the fluid within the fluid line based on the fluid level within thepressure chamber 140A-C. In some embodiments, like thefluid chambers 120A-D, thepressure chambers 140A-C may include reference marks/graduations to improve the accuracy of the level measurement. - In order to aid in the calculation/determination of the volume and/or pressure, some embodiments of the present invention may utilize look-up tables that correlate the imaged fluid level (e.g., the level of the fluid within the
fluid chambers 120A-D and/or the level of fluid within thepressure chambers 140A-C) with a fluid volume in thefluid chamber 120A-D or pressure within the fluid line. For example, for a given container 100 (and/or for a given fluid processing system), the system 200 (e.g., the controller 250) may determine the level of fluid for a given chamber (e.g., using the reference marks) and then refer to the look-up table to find the fluid volume or pressure that correlates to the imaged fluid level. - Once the
system 200/controller 250 has determined the fluid volume and/or pressures, thesystem 200 may display the volume and/or pressure on a display on the system. Additionally or alternatively, thesystem 200 can send the volume and pressure information to the fluid processing system for display and/or use by the fluid processing system. In some embodiments the system 200 (or the fluid processing system) may monitor the fluid volume and/or pressure to determine if the fluid volume reaches a target or threshold level. For example, if the fluid level within one of thefluid chambers 120A-D reaches a target level (e.g., indicating that a target volume of fluid has been collected in thefluid chamber 120A-D), thesystem 200 or the fluid processing system may stop or otherwise alter the fluid processing procedure. Similarly, if the pressure within one or more of thepressure chambers 140A-C goes above or below a threshold level (e.g., indicating that a pressure in one of the fluid lines is too high or too low), thesystem 200 may initiate an alarm or adjust the fluid flow within the fluid line. -
FIG. 3 schematically shows a disposable set for a blood processing device utilizing afluid container 100 andsystem 200 similar to that described above. It is important to note that, unlike thecontainer 100 shown inFIG. 1 (which has threepressure chambers 140A-C and fourfluid chambers 120A-D), thecontainer 100 shown inFIG. 3 has fivefluid chambers 120A-E and nopressure chambers 140A-C. Also, althoughFIG. 3 shows thefluid container 100 being used for blood processing, thecontainer 100 can be used for any number of liquid processing procedures. - During blood processing, whole blood may be drawn from a source (e.g., a patient, a blood storage bag, etc.) using a donor/
draw pump 330, and through adraw line 310. In some embodiments, a portion of the drawn whole blood may flow into thecentrifuge bowl 320 and a portion of the whole blood may be diverted to an in-buffer/draw chamber 120A. Alternatively, all of the whole blood may be diverted to the in-buffer/draw chamber 120A and later drawn from the in-buffer/draw chamber 120A and into thebowl 320. Also, while the whole blood is being drawn from the source, ananticoagulant pump 340 may draw anticoagulant through ananticoagulant line 342 and filter 344 from ananticoagulant source 345. The anticoagulant may mix with the drawn whole blood prior to reaching the in-buffer/draw chamber 120A and/or thebowl 320. To make room for the whole blood entering thebowl 320, the air within thebowl 320 may be displaced via anoutlet 322 andline 370 to anair chamber 120C of thecontainer 100. - Once the initial draw step has commenced and a sufficient amount of anticoagulated whole blood is collected in the in-buffer/
draw chamber 120A, abowl pump 350 may begin to draw anticoagulated whole blood from the in-buffer/draw chamber 120A vialine 352. As thebowl pump 350 draws the anticoagulated whole blood from the in-buffer/draw chamber 120A, valves (not shown) may be opened to allow the anticoagulated whole blood to flow intoline 352. In order to ensure that a sufficient volume of anticoagulated whole blood remains within the in-buffer/draw chamber 120A (e.g., to maintain a continuous flow of anticoagulated whole blood to the bowl 320), thebowl pump 350 may draw the anticoagulated whole blood from the in-buffer/draw chamber 120A at a rate slower than that of thedonor pump 330. For example, thebowl pump 350 may draw at a rate of 60 mL/min as compared to the donor pump's rate of 120 mL/min. Thebowl 320 will continue to fill until anoptical system 360 detects the presence of a plasma/cell interface created by the separation of the whole blood within thebowl 320. - As additional anticoagulated whole blood is introduced into the
bowl 320, the whole blood will continue to separate. For example, the centrifugal forces cause the heavier cellular components of the blood to sediment from the lighter plasma component of the blood. This results in the cell/plasma interface mentioned above. The red blood cells are by far the most numerous of the cellular components of blood and the most dense, resulting in a layer of concentrated red blood cells at the outermost diameter of thebowl 320. As filling continues, the other cellular components of blood begin to become apparent. These cellular components are primarily platelets, leukocytes and peripheral hematopoietic progenitor stem cells. These cells may have a range of densities between that of the red blood cells and plasma. Therefore they tend to sediment in a layer between the red blood cell layer and plasma layer. As this layer grows, it is visually apparent as a solid white layer which is known as a buffy coat. - As the
bowl 320 continues to fill with whole blood, the red blood cells will continue to sediment to the outermost diameter, and the intermediate cells of the buffy coat will continue to accumulate at the red blood cell/plasma interface, and the plasma interface will move inward towards the center of thebowl 320. When thebowl 320 is full, the plasma will exit thebowl 320 via theoutlet 322. As the plasma exits thebowl 320, some of the plasma may pass throughline 370 and into an outbuffer chamber 120E of thecontainer 100 and some of the plasma may be sequestered within theplasma chamber 120B of thecontainer 100. To sequester this plasma in theplasma chamber 120B, the operator or the control system of the blood processing system can open valve C3 to allow some of the plasma exiting thebowl 320 to enterline 372 and flow into theplasma chamber 120B. The sequestered plasma in theplasma chamber 120B may be used during a surge elutriation procedure to remove the platelets from thebowl 320. - In some embodiments, the
bowl 320 may be a continuous flow bowl that allows the continuous processing of whole blood without the need to intermittently stop. To that end, various embodiments of the present invention also extract red blood cells from thebowl 320 as additional whole blood is introduced (e.g., while simultaneously extracting plasma). For example, once the red blood cells have collected within thebowl 320, a redblood cell pump 380 can draw red blood cells out of an additional output 324 (e.g., a first blood component/red blood cell outlet) on thebowl 320. As the red blood cells leave thebowl 320, they will pass throughline 385 and into theout buffer chamber 120E (e.g., which acts as a return chamber). While the redblood cell pump 380 extracts the red blood cells, theoptical system 360 will monitor the location of the plasma/cell interface and may control the flow rate of the redblood cell pump 380 to adjust the location of the interface as necessary (e.g., it will speed up thepump 380 if the sensor output decreases and slow down thepump 380 if the sensor output increases). - Once the
donor pump 330 has drawn a predetermined volume of whole blood from the source, thesystem 300 will stop the draw step and begin to return some of the blood components (e.g., red blood cells and plasma) that have been collected in the out buffer/return chamber 120E. For example, thesystem 300 may energize areturn pump 390, which will draw (e.g., at 120 mL/min) the plasma and red blood cells within the out buffer/return chamber 120E throughline 395, and back to the source (e.g., back to the patient). This return phase will continue until a predetermined volume of red blood cells and plasma are returned to the subject, for example, 80 mL. Thesystem 300 may then alternate the draw and return phases until the procedure is complete. In some embodiments, a compensation fluid such as saline may be returned to the patient along with the blood components within the out buffer/return chamber 120E. In such embodiments, thereturn pump 390 may draw the compensation fluid from acontainer 440 and through acompensation line 445. - In continuous systems like that shown in
FIG. 3 , anticoagulated whole blood may be continuously drawn from the in-buffer/draw chamber 120A and into thebowl 320, even during the return phase. As mentioned above, this can be accomplished by first drawing a bolus volume of whole blood from the subject, collecting the bolus volume of whole blood within the in-buffer/draw chamber 120A, and drawing the whole blood from the in-buffer/draw chamber 120A at a slower rate than the draw and return steps (e.g., thebowl pump 350 draws the anticoagulated whole blood at 60 mL/min and thedonor pump 330 draws the whole blood from the subject and returns the red blood cells and plasma to the subject at 120 mL/min). Therefore, the in-buffer/draw chamber 120A always has a sufficient volume of anticoagulated whole blood from which thebowl pump 350 can draw. - The whole blood processing may continue until a desired volume of platelets has accumulated within the
bowl 320. When the blood processing is complete, thesystem 300 may then perform a surge elutriation process using the sequestered plasma in order to extract the highly concentrated platelet product. For example, thebowl pump 350 can draw the plasma within theplasma chamber 120B through aplasma recirculation line 354 and into the bowl 320 (e.g., via the inlet 326). To elutriate the platelets, the flow rate of plasma is gradually increased. As the flow rate is increased, the effluent plasma passes through a line sensor 374 (located on line 370) that monitors the fluid exiting thebowl 320. At some point in this ramping up of plasma flow rate, the drag force created by the plasma flow overcomes the centrifugal force caused by the bowl rotation, and the platelets are carried away from the buffy coat in the flowing plasma. Theline sensor 374 may then detect the presence of cells (e.g., as the fluid exiting thebowl 320 changes from plasma to platelets), and the system 300 (or the user) can close valve C3 and open valve C5 to allow the platelets to flow into theplatelet line 376 and into theplatelet chamber 120D of thecontainer 100. - After the elutriation process and after the platelets are collected within the
platelet chamber 120D, thesystem 300 may stop thebowl 320 and return the contents of thebowl 320 to the donor. For example, thesystem 300 may turn on the redblood cell pump 380 to draw the contents of thebowl 320 into the out buffer/return chamber 120E (via line 385). Thereturn pump 390 may then draw the contents of the out buffer/return chamber 120E throughline 395, and return the components via thereturn line 397. Additionally, in some applications, platelet additive solution may be added to the platelets within theplatelet chamber 120D (from plateletadditive solution container 430 and vialine 435 and valve C6), and the platelets may be filtered using aplatelet filter 410 and transferred to a filteredplatelet container 420 vialine 415. - Throughout the blood processing procedure, the
vision system 200 can monitor the fluid levels in each of thechambers 120A-E in manner similar to that described above. For example, as the plasma enters or is drawn from theplasma chamber 120B, platelets enter/are drawn from theplatelets chamber 120D, and when plasma and/or red blood cells enter/are drawn from the out buffer/return chamber 120E, thevision system 200 can monitor the volumes collected and/or remaining in each of thechambers 120A-E. Additionally, thevision system 200 may monitor the level of whole blood within the in-buffer/draw chamber 120A to ensure that the in-buffer/draw chamber 120A contains sufficient whole blood to continuously supply thebowl 320 with whole blood. Theblood processing system 300 may then use this information to adjust/alter/control the blood processing procedure. For example, theblood processing system 300 can control the pumps,centrifuge bowl 320, valves, or other components of the system based upon the volumes. - Although
FIG. 3 illustrates ablood processing system 300 utilizing acontainer 100 without pressure chambers, as noted above, other embodiments may include pressure chambers to allow thevision system 200 and/or the blood processing system to measure the pressures within one or more of the fluid lines. For example,FIG. 4 shows a layout of theblood processing system 300 with acontainer 100 with fivefluid chambers 120A-E (like the container shown inFIG. 3 ), and threepressure chambers 140A-C. It should be noted that the operation of theblood processing system 300 is similar to that shown inFIG. 3 (including the roles of each of thefluid chambers 120A-E) and described above. - As shown in
FIG. 4 , ananticoagulant pressure chamber 140A may connect to theanticoagulant line 342 atpressure connection 346. Similarly, adraw pressure chamber 140B may connect to thedraw line 310 atpressure connection 315, and aseal pressure chamber 140C may connect toline 370 extending fromoutlet 322 at pressure connection 375 (seeFIG. 3 ). It should be noted that, although the embodiment shown inFIG. 4 does not include a pressure chamber connected to the red blood cell pressure connection 387 (e.g., it uses a standard pressure transducer to measure the pressure within the red blood cell line 385), other embodiments can include a fourth pressure chamber that is connected to the redblood cell line 385 atpressure connection 387. - During blood processing, a portion of the fluid in each of the fluid lines (e.g., the
anticoagulant line 342, thedraw line 310, and line 370) will enter thepressure chambers 140A-C and cause the volume of air within each of thechambers 140A-C to compress. Then, as the pressure within each of thelines 310/341/370 changes, the pressure change will be translated to thepressure chambers 140A-C, causing the volume of air in thechambers 140A-C to compress further if the pressure increases and/or expand if the pressure decreases (e.g., the fluid level within thechambers 140A-C will move up and/or down). Thevision system 200 may then monitor the fluid level within each of thechambers 140A-C and determine the respective pressure within the connected line (e.g., withinlines system 200 may then send this pressure information to the blood processing system 300 (e.g., to a controller within the blood processing system 300) along with the fluid volume information determined from thefluid chambers 120A-E. Theblood processing system 300 may then adjust/alter/control the blood processing procedure. For example, theblood processing system 300 can control the pumps,centrifuge bowl 320, valves, or other components of the system based upon the measured pressures (and/or volumes). - It should be noted that, although the blood processing method discussed above draws whole blood from and returns the contents of the bowl to a donor, some embodiments may not draw from and/or return to a donor. Rather, in some embodiments, the whole blood may be drawn from a whole blood storage container, and the contents of the
bowl 320 may be returned to the whole blood storage container (or a different blood storage container). - It is important to note that, in addition to providing an accurate volume and pressure measurement, embodiments of the present invention provide additional benefits over prior art containers and pressure/volume measurement system. For example, because the
container 100 includesindividual chambers 120A-D for a number of fluids collected and used during fluid processing, thecontainer 100 may be installed as a single piece as opposed to several separate containers. This, in turn, simplifies installation/loading and reduces installation/loading time. Additionally, by adding additional chambers to thecontainer 100, embodiments of the present invention are able to further reduce the complexity of the fluid processing system (e.g., the blood processing system 300), system calibration, and cost, while increasing reliability. - The embodiments of the invention described above are intended to be merely exemplary; numerous variations and modifications will be apparent to those skilled in the art. All such variations and modifications are intended to be within the scope of the present invention as defined in any appended claims.
Claims (46)
Priority Applications (1)
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US15/769,179 US20180306661A1 (en) | 2015-10-27 | 2016-10-27 | System and Method for Measuring Volume and Pressure |
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US201562246795P | 2015-10-27 | 2015-10-27 | |
PCT/US2016/059017 WO2017075153A1 (en) | 2015-10-27 | 2016-10-27 | System and method for measuring volume and pressure |
US15/769,179 US20180306661A1 (en) | 2015-10-27 | 2016-10-27 | System and Method for Measuring Volume and Pressure |
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US20190167897A1 (en) * | 2016-08-24 | 2019-06-06 | Avent, Inc. | Flow Indicator for an Infusion Pump |
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DE102018119951A1 (en) | 2018-08-16 | 2020-02-20 | Endress + Hauser Messtechnik Gmbh+Co. Kg | Procedure for determining a remaining empty volume, procedure for on-site calibration of a level measuring device and on-site calibration module |
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WO1999020983A2 (en) * | 1997-10-22 | 1999-04-29 | Argonaut Technologies, Inc. | Systems and methods using an optical sensor for liquid metering |
DE19800131C1 (en) * | 1998-01-03 | 1999-05-20 | Foerderung Angewandter Informa | Apparatus to detect and measure contents of miniature vessels |
US6494344B1 (en) * | 2001-09-28 | 2002-12-17 | Joseph A. Kressel, Sr. | Liquid dispensing container |
JP4095968B2 (en) * | 2004-02-06 | 2008-06-04 | 株式会社日立ハイテクノロジーズ | Liquid dispensing device, automatic analyzer using the same, and liquid level detecting device |
EP1747994A1 (en) * | 2005-07-28 | 2007-01-31 | I.D.M. Immuno-Designed Molecules | Serially linked containers for containing a sterile solution |
KR100724103B1 (en) * | 2005-10-04 | 2007-06-04 | 한국표준과학연구원 | Pressure measuring system of a vacuum container using infrared camera |
US7472593B2 (en) * | 2005-12-01 | 2009-01-06 | Cytyc Corporation | Fluid level regulator |
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EP2191897B1 (en) * | 2007-06-21 | 2014-02-26 | Gen-Probe Incorporated | Instrument and receptacles for performing processes |
US20090211962A1 (en) * | 2008-02-27 | 2009-08-27 | Kyungyoon Min | Processing chambers for use with apheresis devices |
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JP5950126B2 (en) * | 2011-07-08 | 2016-07-13 | パナソニックIpマネジメント株式会社 | Solid-state imaging device and imaging apparatus |
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- 2016-10-27 EP EP16860756.2A patent/EP3368869B1/en active Active
- 2016-10-27 WO PCT/US2016/059017 patent/WO2017075153A1/en active Application Filing
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US20190167897A1 (en) * | 2016-08-24 | 2019-06-06 | Avent, Inc. | Flow Indicator for an Infusion Pump |
US10737023B2 (en) * | 2016-08-24 | 2020-08-11 | Avent, Inc. | Flow indicator for an infusion pump |
US11752261B2 (en) | 2016-08-24 | 2023-09-12 | Avent, Inc. | Flow indicator for an infusion pump |
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US20210310887A1 (en) | 2021-10-07 |
EP3368869B1 (en) | 2023-12-06 |
WO2017075153A1 (en) | 2017-05-04 |
US11592348B2 (en) | 2023-02-28 |
EP3368869A4 (en) | 2019-07-17 |
EP3368869A1 (en) | 2018-09-05 |
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