US20180127834A1

US20180127834A1 - Predicting breast cancer treatment outcome

Info

Publication number: US20180127834A1
Application number: US15/807,474
Authority: US
Inventors: Mark G. Erlander; Xiao-Jun Ma; Dennis C. Sgroi
Original assignee: General Hospital Corp; Biotheranostics Inc
Current assignee: General Hospital Corp; Biotheranostics Inc
Priority date: 2003-09-19
Filing date: 2017-11-08
Publication date: 2018-05-10
Also published as: US9856533B2; EP2333119A1; US20050239083A1

Abstract

Methods and compositions are provided for the identification of expression signatures in ER+ breast cancer cases, where the signatures correlate with responsiveness, or lack thereof, to treatment with tamoxifen or another antiestrogen agent against breast cancer The signature profiles are identified based upon sampling of reference breast tissue samples from independent cases of breast cancer and provide a reliable set of molecular criteria for predicting the efficacy of treating a subject with breast cancer with tamoxifen or another antiestrogen agent against breast cancer. Additional methods and compositions are provided for predicting responsiveness to tamoxifen or another antiestrogen agent against breast cancer in cases of breast cancer by use of three biomarkers. Two biomarkers display increased expression correlated with tamoxifen response while the third biomarker displays decreased expression correlated with tamoxifen response.

Description

RELATED APPLICATIONS

This application claims benefit of priority from U.S. Provisional Patent Application 60/504,087, filed Sep. 19, 2003, and is a continuation in part of U.S. patent application Ser. No. 10/727,100, filed Dec. 2, 2003. Both applications are hereby incorporated by reference in their entireties as if fully set forth.

FIELD OF THE INVENTION

The invention relates to the identification and use of gene expression profiles, or patterns, with clinical relevance to the treatment of breast cancer using tamoxifen (nolvadex) and other “antiestrogen” agents against breast cancer, including other “selective estrogen receptor modulators” (“SERM” s), “selective estrogen receptor downregulators” (“SERD” s), and aromatase inhibitors (“AI” s). In particular, the invention provides the identities of gene sequences the expression of which are correlated with patient survival and breast cancer recurrence in women treated with tamoxifen or other “antiestrogen” agents against breast cancer. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to select subjects afflicted with breast cancer who will likely respond positively to treatment with tamoxifen or another “antiestrogen” agent against breast cancer as well as those who will likely be non-responsive and thus candidates for other treatments. The invention also provides the identities of three sets of sequences from three genes with expression patterns that are strongly predictive of responsiveness to tamoxifen and other “antiestrogen” agents against breast cancer.

BACKGROUND OF THE INVENTION

Breast cancer is by far the most common cancer among women. Each year, more than 180,000 and 1 million women in the U.S. and worldwide, respectively, are diagnosed with breast cancer. Breast cancer is the leading cause of death for women between ages 50-55, and is the most common non-preventable malignancy in women in the Western Hemisphere. An estimated 2,167,000 women in the United States are currently living with the disease (National Cancer Institute, Surveillance Epidemiology and End Results (NCI SEER) program, Cancer Statistics Review (CSR), www-seer.ims.nci.nih.gov/Publications/CSR1973 (1998)). Based on cancer rates from 1995 through 1997, a report from the National Cancer Institute (NCI) estimates that about 1 in 8 women in the United States (approximately 12.8 percent) will develop breast cancer during her lifetime (NCI's Surveillance, Epidemiology, and End Results Program (SEER) publication SEER Cancer Statistics Review 1973-1997). Breast cancer is the second most common form of cancer, after skin cancer, among women in the United States. An estimated 250,100 new cases of breast cancer are expected to be diagnosed in the United States in 2001. Of these, 192,200 new cases of more advanced (invasive) breast cancer are expected to occur among women (an increase of 5% over last year), 46,400 new cases of early stage (in situ) breast cancer are expected to occur among women (up 9% from last year), and about 1,500 new cases of breast cancer are expected to be diagnosed in men (Cancer Facts & FIGURES 2001 American Cancer Society). An estimated 40,600 deaths (40,300 women, 400 men) from breast cancer are expected in 2001. Breast cancer ranks second only to lung cancer among causes of cancer deaths in women. Nearly 86% of women who are diagnosed with breast cancer are likely to still be alive five years later, though 24% of them will die of breast cancer after 10 years, and nearly half (47%) will die of breast cancer after 20 years.
Every woman is at risk for breast cancer. Over 70 percent of breast cancers occur in women who have no identifiable risk factors other than age (U.S. General Accounting Office. Breast Cancer, 1971-1991: Prevention, Treatment and Research. GAO/PEMD-92-12; 1991). Only 5 to 10% of breast cancers are linked to a family history of breast cancer (Henderson I C, Breast Cancer. In: Murphy G P, Lawrence W L, Lenhard R E (eds). Clinical Oncology. Atlanta, Ga.: American Cancer Society; 1995:198-219).
Each breast has 15 to 20 sections called lobes. Within each lobe are many smaller lobules. Lobules end in dozens of tiny bulbs that can produce milk. The lobes, lobules, and bulbs are all linked by thin tubes called ducts. These ducts lead to the nipple in the center of a dark area of skin called the areola. Fat surrounds the lobules and ducts. There are no muscles in the breast, but muscles lie under each breast and cover the ribs. Each breast also contains blood vessels and lymph vessels. The lymph vessels carry colorless fluid called lymph, and lead to the lymph nodes. Clusters of lymph nodes are found near the breast in the axilla (under the arm), above the collarbone, and in the chest.
Breast tumors can be either benign or malignant. Benign tumors are not cancerous, they do not spread to other parts of the body, and are not a threat to life. They can usually be removed, and in most cases, do not come back. Malignant tumors are cancerous, and can invade and damage nearby tissues and organs. Malignant tumor cells may metastasize, entering the bloodstream or lymphatic system. When breast cancer cells metastasize outside the breast, they are often found in the lymph nodes under the arm (axillary lymph nodes). If the cancer has reached these nodes, it means that cancer cells may have spread to other lymph nodes or other organs, such as bones, liver, or lungs.
Major and intensive research has been focused on early detection, treatment and prevention. This has included an emphasis on determining the presence of precancerous or cancerous ductal epithelial cells. These cells are analyzed, for example, for cell morphology, for protein markers, for nucleic acid markers, for chromosomal abnormalities, for biochemical markers, and for other characteristic changes that would signal the presence of cancerous or precancerous cells. This has led to various molecular alterations that have been reported in breast cancer, few of which have been well characterized in human clinical breast specimens. Molecular alterations include presence/absence of estrogen and progesterone steroid receptors, HER-2 expression/amplification (Mark H F, et al. HER-2/neu gene amplification in stages I-IV breast cancer detected by fluorescent in situ hybridization. Genet Med; 1(3):98-103 1999), Ki-67 (an antigen that is present in all stages of the cell cycle except G0 and used as a marker for tumor cell proliferation, and prognostic markers (including oncogenes, tumor suppressor genes, and angiogenesis markers) like p53, p27, Cathepsin D, pS2, multi-drug resistance (MDR) gene, and CD31.
Tamoxifen is the antiestrogen agent most frequently prescribed in women with both early stage and metastatic hormone receptor-positive breast cancer (for reviews, see Clarke, R. et al. “Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling.” Oncogene 22, 7316-39 (2003) and Jordan, C. “Historical perspective on hormonal therapy of advanced breast Cancer.” Clin. Ther. 24 Suppl A, A3-16 (2002)). In the adjuvant setting, tamoxifen therapy results in a 40-50% reduction in the annual risk of recurrence, leading to a 5.6% improvement in 10 year survival in lymph node negative patients, and a corresponding 10.9% improvement in node-positive patients (Group, E.B.C.T.C. Tamoxifen for early breast cancer. Cochrane Database Syst Rev, CD000486 (2001)). Tamoxifen is thought to act primarily as a competitive inhibitor of estrogen binding to estrogen receptor (ER). The absolute levels of ER expression, as well as that of the progesterone receptor (PR, an indicator of a functional ER pathway), are currently the best predictors of tamoxifen response in the clinical setting (Group, (2001) and Bardou, V. J. et al. “Progesterone receptor status significantly improves outcome prediction over estrogen receptor status alone for adjuvant endocrine therapy in two large breast cancer databases.” J Clin Oncol 21, 1973-9 (2003)).
However, 25% of ER+/PR+ tumors, 66% of ER+/PR− cases and 55% of ER−/PR+ cases fail to respond, or develop early resistance to tamoxifen, through mechanisms that remain largely unclear (see Clarke et al.; Nicholson, R. I. et al. “The biology of antihormone failure in breast cancer.” Breast Cancer Res Treat 80 Suppl 1, S29-34; discussion S35 (2003) and Osborne, C. K. et al. “Growth factor receptor cross-talk with estrogen receptor as a mechanism for tamoxifen resistance in breast cancer.” Breast 12, 362-7 (2003)). Currently, no reliable means exist to allow the identification of these non-responders. In these patients, the use of alternative hormonal therapies, such as the aromatase inhibitors letrozole and anastrozole (Ellis, M. J. et al. “Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptorpositive primary breast cancer: evidence from a phase III randomized trial.” J Clin Oncol 19, 3808-16 (2001); Buzdar, A. U. “Anastrozole: a new addition to the armamentarium against advanced breast cancer.” Am J Clin Oncol 21, 161-6 (1998); and Goss, P. E. et al. “A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer.” N Engl J Med 349, 1793-802 (2003)); chemotherapeutic agents, or inhibitors of other signaling pathways, such as trastuzmab and gefitinib might offer the possibility of improving clinical outcome. Therefore, the ability to accurately predict tamoxifen treatment outcome should significantly advance the management of early stage breast cancer by identifying patients who are unlikely to benefit from TAM so that additional or alternative therapies may be sought.
Citation of documents herein is not intended as an admission that any is pertinent prior art. All statements as to the date or representation as to the contents of documents is based on the information available to the applicant and does not constitute any admission as to the correctness of the dates or contents of the documents.

SUMMARY OF THE INVENTION

The present invention relates to the identification and use of gene expression patterns (or profiles or “signatures”) and the expression levels of individual gene sequences which are clinically relevant to breast cancer. In particular, the identities of genes that are correlated with patient survival and breast cancer recurrence (e.g. metastasis of the breast cancer) are provided. The gene expression profiles, whether embodied in nucleic acid expression, protein expression, or other expression formats, may be used to predict survival of subjects afflicted with breast cancer and the likelihood of breast cancer recurrence, including cancer metastasis.
The invention thus provides for the identification and use of gene expression patterns (or profiles or “signatures”) and the expression levels of individual gene sequences which correlate with (and thus are able to discriminate between) patients with good or poor survival outcomes. In one embodiment, the invention provides patterns that are able to distinguish patients with estrogen receptor (a isoform) positive (ER+) breast tumors into those with that are responsive, or likely to be responsive, to treatment with tamoxifen (TAM) or another “antiestrogen” agent against breast cancer (such as a “selective estrogen receptor modulator” (“SERM”), “selective estrogen receptor downregulator” (“SERD”), or aromatase inhibitor (“AI”)) and those that are non-responsive, or likely to be non-responsive, to such treatment. In an alternative embodiment, the invention may be applied to patients with breast tumors that do not display detectable levels of ER expression (so called “ER−” subjects) but where the patient will nonetheless benefit from application of the invention due to the presence of some low level ER expression. Responsiveness may be viewed in terms of better survival outcomes over time. These patterns are thus able to distinguish patients with ER+ breast tumors into at least two subtypes.
In a first aspect, the present invention provides a non-subjective means for the identification of patients with breast cancer (ER+ or ER−) as likely to have a good or poor survival outcome following treatment with TAM or another “antiestrogen” agent against breast cancer by assaying for the expression patterns disclosed herein. Thus where subjective interpretation may have been previously used to determine the prognosis and/or treatment of breast cancer patients, the present invention provides objective gene expression patterns, which may used alone or in combination with subjective criteria to provide a more accurate assessment of ER+ or ER− breast cancer patient outcomes or expected outcomes, including survival and the recurrence of cancer, following treatment with TAM or another “antiestrogen” agent against breast cancer. The expression patterns of the invention thus provide a means to determine ER+ or ER− breast cancer prognosis. Furthermore, the expression patterns can also be used as a means to assay small, node negative tumors that are not readily assayed by other means.
The gene expression patterns comprise one or more than one gene capable of discriminating between breast cancer outcomes with significant accuracy. The gene sequence(s) are identified as correlated with ER+ breast cancer outcomes such that the levels of their expression are relevant to a determination of the preferred treatment protocols for a patient, whether ER+ or ER−. Thus in one embodiment, the invention provides a method to determine the outcome of a subject afflicted with breast cancer by assaying a cell containing sample from said subject for expression of one or more than one gene disclosed herein as correlated with breast cancer outcomes following treatment with TAM or another “antiestrogen” agent against breast cancer.
The ability to correlate gene expression with breast cancer outcome and responsiveness to TAM is particularly advantageous in light of the possibility that up to 40% of ER+ subjects that undergo TAM treatment are non-responders. Therefore, the ability to identify, with confidence, these non-responders at an early time point permits the consideration and/or application of alternative therapies (such as a different “antiestrogen” agent against breast cancer or other anti-breast cancer treatments) to the non-responders. Stated differently, the ability to identify TAM non-responder subjects permits medical personnel to consider and/or utilize alternative therapies for the treatment of the subjects before time is spent on ineffective TAM therapy. Time spent on an ineffective therapy often permits further cancer growth, and the likelihood of success with alternative therapies diminishes over time given such growth. Therefore, the invention also provides methods to improve the survival outcome of non-responders by use of the methods disclosed herein to identify non-responders for treatment with alternative therapies.
Gene expression patterns of the invention are identified as described below. Generally, a large sampling of the gene expression profile of a sample is obtained through quantifying the expression levels of mRNA corresponding to many genes. This profile is then analyzed to identify genes, the expression of which are positively, or negatively, correlated, with ER+ breast cancer outcome upon treatment with TAM or another “antiestrogen” agent against breast cancer. An expression profile of a subset of human genes may then be identified by the methods of the present invention as correlated with a particular outcome. The use of multiple samples increases the confidence which a gene may be believed to be correlated with a particular survival outcome. Without sufficient confidence, it remains unpredictable whether expression of a particular gene is actually correlated with an outcome and also unpredictable whether expression of a particular gene may be successfully used to identify the outcome for a breast cancer patient. While the invention may be practiced based on the identities of the gene sequences disclosed herein or the actual sequences used independent of identification, the invention may also be practiced with any other sequences the expression of which is correlated with the expression of sequences disclosed herein. Such additional sequences may be identified by any means known in the art, including the methods disclosed herein.
A profile of genes that are highly correlated with one outcome relative to another may be used to assay an sample from a subject afflicted with breast cancer to predict the likely responsiveness (or lack thereof) to TAM or another “antiestrogen” agent against breast cancer in the subject from whom the sample was obtained. Such an assay may be used as part of a method to determine the therapeutic treatment for said subject based upon the breast cancer outcome identified.
As discussed below, the correlated genes may be used singly with significant accuracy or in combination to increase the ability to accurately correlating a molecular expression phenotype with a breast cancer outcome. This correlation is a way to molecularly provide for the determination of survival outcomes as disclosed herein. Additional uses of the correlated gene(s) are in the classification of cells and tissues; determination of diagnosis and/or prognosis; and determination and/or alteration of therapy.
The ability to discriminate is conferred by the identification of expression of the individual genes as relevant and not by the form of the assay used to determine the actual level of expression. An assay may utilize any identifying feature of an identified individual gene as disclosed herein as long as the assay reflects, quantitatively or qualitatively, expression of the gene in the “transcriptome” (the transcribed fraction of genes in a genome) or the “proteome” (the translated fraction of expressed genes in a genome). Additional assays include those based on the detection of polypeptide fragments of the relevant member or members of the proteome. Identifying features include, but are not limited to, unique nucleic acid sequences used to encode (DNA), or express (RNA), said gene or epitopes specific to, or activities of, a protein encoded by said gene. All that is required are the gene sequence(s) necessary to discriminate between breast cancer outcomes and an appropriate cell containing sample for use in an expression assay.
In another embodiment, the invention provides for the identification of the gene expression patterns by analyzing global, or near global, gene expression from single cells or homogenous cell populations which have been dissected away from, or otherwise isolated or purified from, contaminating cells beyond that possible by a simple biopsy. Because the expression of numerous genes fluctuate between cells from different patients as well as between cells from the same patient sample, multiple data from expression of individual genes and gene expression patterns are used as reference data to generate models which in turn permit the identification of individual gene(s), the expression of which are most highly correlated with particular breast cancer outcomes.
In additional embodiments, the invention provides physical and methodological means for detecting the expression of gene(s) identified by the models generated by individual expression patterns. These means may be directed to assaying one or more aspects of the DNA template(s) underlying the expression of the gene(s), of the RNA used as an intermediate to express the gene(s), or of the proteinaceous product expressed by the gene(s).
In further embodiments, the gene(s) identified by a model as capable of discriminating between breast cancer outcomes may be used to identify the cellular state of an unknown sample of cell(s) from the breast. Preferably, the sample is isolated via non-invasive means. The expression of said gene(s) in said unknown sample may be determined and compared to the expression of said gene(s) in reference data of gene expression patterns correlated with breast cancer outcomes. Optionally, the comparison to reference samples may be by comparison to the model(s) constructed based on the reference samples.
One advantage provided by the present invention is that contaminating, non-breast cells (such as infiltrating lymphocytes or other immune system cells) are not present to possibly affect the genes identified or the subsequent analysis of gene expression to identify the survival outcomes of patients with breast cancer. Such contamination is present where a biopsy is used to generate gene expression profiles. However, and as noted herein, the invention includes the identity of genes that may be used with significant accuracy even in the presence of contaminating cells.
In a second aspect, the invention provides a non-subjective means based on the expression of three genes, or combinations thereof, for the identification of patients with breast cancer as likely to have a good or poor survival outcome following treatment with TAM or another “antiestrogen” agent against breast cancer. These three genes are members of the expression patterns disclosed herein which have been found to be strongly predictive of clinical outcome following TAM treatment of ER+ breast cancer.
The present invention thus provides gene sequences identified as differentially expressed in ER+ breast cancer in correlation to TAM responsiveness. The sequences of two of the genes display increased expression in ER+ breast cells that respond to TAM treatment (and thus lack of increased expression in nonresponsive cases). The sequences of the third gene display decreased expression in ER+ breast cells that respond to TAM treatment (and thus lack of decreased expression in nonresponsive cases).
The first set of sequences found to be more highly expressed in TAM responsive, ER+ breast cells are those of interleukin 17 receptor B (IL17RB), which has been mapped to human chromosome 3 at 3p21.1. IL17RB is also referred to as interleukin 17B receptor (IL17BR) and sequences corresponding to it, and thus may be used in the practice of the instant invention, are identified by UniGene Cluster Hs.5470.
The second set of sequences found to be more highly expressed in TAM responsive, ER+ breast cells are those of the calcium channel, voltage-dependent, L type, alpha 1D subunit (CACNA1D), which has been mapped to human chromosome 3 at 3p14.3. Sequences corresponding to CACNA1D, and thus may be used in the practice of the instant invention, are identified by UniGene Cluster Hs.399966.
The set of sequences found to be expressed at lower levels in TAM responsive, ER+ breast cells are those of homeobox B13 (HOXB13), which has been mapped to human chromosome 17 at 17q21.2. Sequences corresponding to HOXB13, and thus may be used in the practice of the instant invention, are identified by UniGene Cluster Hs.66731.
While the invention may be practiced based on the identities of these three gene sequences or the actual sequences used independent of the assigned identity, the invention may also be practiced with any other sequence the expression of which is correlated with the expression of these disclosed sequences. Such additional sequences may be identified by any means known in the art, including the methods disclosed herein.
The identified sequences may thus be used in methods of determining the responsiveness, or non-responsiveness, of a subject's ER+ or ER− breast cancer to TAM treatment, or treatment with another “antiestrogen” agent against breast cancer, via analysis of breast cells in a tissue or cell containing sample from a subject. As non-limiting examples, the lack of increased expression of IL17BR and CACNA1D sequences and/or the lack of decreased expression of HOXB13 sequences may be used as an indicator of nonresponsive cases. The present invention provides an non-empirical means for determining responsiveness to TAM or another SERM in ER+ or ER− patients. This provides advantages over the use of a “wait and see” approach following treatment with TAM or other “antiestrogen” agent against breast cancer. The expression levels of these sequences may also be used as a means to assay small, node negative tumors that are not readily assessed by conventional means.
The expression levels of the identified sequences may be used alone or in combination with other sequences capable of determining responsiveness to treatment with TAM or another “antiestrogen” agent against breast cancer. Preferably, the sequences of the invention are used alone or in combination with each other, such as in the format of a ratio of expression levels that can have improved predictive power over analysis based on expression of sequences corresponding to individual genes. The invention provides for ratios of the expression level of a sequence that is underexpressed to the expression level of a sequence that is overexpressed as a indicator of responsiveness or non-responsiveness.
The present invention provides means for correlating a molecular expression phenotype with a physiological response in a subject with ER+ or ER− breast cancer. This correlation provides a way to molecularly diagnose and/or determine treatment for a breast cancer afflicted subject. Additional uses of the sequences are in the classification of cells and tissues; and determination of diagnosis and/or prognosis. Use of the sequences to identify cells of a sample as responsive, or not, to treatment with TAM or other “antiestrogen” agent against breast cancer may be used to determine the choice, or alteration, of therapy used to treat such cells in the subject, as well as the subject itself, from which the sample originated.
Such methods of the invention may be used to assist the determination of providing tamoxifen or another “antiestrogen” agent against breast cancer as a chemopreventive or chemoprotective agent to a subject at high risk for development of breast cancer. These methods of the invention are an advance over the studies of Fabian et al. (J Natl Cancer Inst. 92(15):1217-27, 2000), which proposed a combination of cytomorphology and the Gail risk model to identify high risk patients. The methods may be used in combination with assessments of relative risk of breast cancer such as that discussed by Tan-Chiu et al. (J Natl Cancer Inst. 95(4):302-307, 2003). Non-limiting examples include assaying of minimally invasive sampling, such as random (periareolar) fine needle aspirates or ductal lavage samples (such as that described by Fabian et al. and optionally in combination with or as an addition to a mammogram positive for benign or malignant breast cancer), of breast cells for the expression levels of gene sequences as disclosed herein to assist in the determination of administering therapy with an “antiestrogen” agent against breast cancer, such as that which may occur in cases of high risk subjects (like those described by Tan-Chiu et al.). The assays would thus lead to the identification of subjects for who the application of an “antiestrogen” agent against breast cancer would likely be beneficial as a chemopreventive or chemoprotective agent. It is contemplated that such application as enabled by the instant invention could lead to beneficial effects such as those seen with the administration of tamoxifen (see for example, Wickerham D. L., Breast Cancer Res. and Treatment 75 Suppl 1:S7-12, Discussion S33-5, 2000). Other applications of the invention include assaying of advanced breast cancer, including metastatic cancer, to determine the responsiveness, or non-responsiveness, thereof to treatment with an “antiestrogen” agent against breast cancer.
An assay of the invention may utilize a means related to the expression level of the sequences disclosed herein as long as the assay reflects, quantitatively or qualitatively, expression of the sequence. Preferably, however, a quantitative assay means is preferred. The ability to determine responsiveness to TAM or other “antiestrogen” agent against breast cancer and thus outcome of treatment therewith is provided by the recognition of the relevancy of the level of expression of the identified sequences and not by the form of the assay used to determine the actual level of expression. Identifying features of the sequences include, but are not limited to, unique nucleic acid sequences used to encode (DNA), or express (RNA), the disclosed sequences or epitopes specific to, or activities of, proteins encoded by the sequences. Alternative means include detection of nucleic acid amplification as indicative of increased expression levels and nucleic acid inactivation, deletion, or methylation, as indicative of decreased expression levels. Stated differently, the invention may be practiced by assaying one or more aspect of the DNA template(s) underlying the expression of the disclosed sequence(s), of the RNA used as an intermediate to express the sequence(s), or of the proteinaceous product expressed by the sequence(s), as well as proteolytic fragments of such products. As such, the detection of the presence of, amount of, stability of, or degradation (including rate) of, such DNA, RNA and proteinaceous molecules may be used in the practice of the invention.
The practice of the present invention is unaffected by the presence of minor mismatches between the disclosed sequences and those expressed by cells of a subject's sample. A non-limiting example of the existence of such mismatches are seen in cases of sequence polymorphisms between individuals of a species, such as individual human patients within Homo sapiens. Knowledge that expression of the disclosed sequences (and sequences that vary due to minor mismatches) is correlated with the presence of non-normal or abnormal breast cells and breast cancer is sufficient for the practice of the invention with an appropriate cell containing sample via an assay for expression.
In one embodiment, the invention provides for the identification of the expression levels of the disclosed sequences by analysis of their expression in a sample containing ER+ or ER− breast cells. In one preferred embodiment, the sample contains single cells or homogenous cell populations which have been dissected away from, or otherwise isolated or purified from, contaminating cells beyond that possible by a simple biopsy. Alternatively, undissected cells within a “section” of tissue may be used. Multiple means for such analysis are available, including detection of expression within an assay for global, or near global, gene expression in a sample (e.g. as part of a gene expression profiling analysis such as on a microarray) or by specific detection, such as quantitative PCR (Q-PCR), or real time quantitative PCR.
Preferably, the sample is isolated via non-invasive or minimally invasive means. The expression of the disclosed sequence(s) in the sample may be determined and compared to the expression of said sequence(s) in reference data of non-normal or cancerous breast cells. Alternatively, the expression level may be compared to expression levels in normal or non-cancerous cells, preferably from the same sample or subject. In embodiments of the invention utilizing Q-PCR, the expression level may be compared to expression levels of reference genes in the same sample or a ratio of expression levels may be used.
When individual breast cells are isolated in the practice of the invention, one benefit is that contaminating, non-breast cells (such as infiltrating lymphocytes or other immune system cells) are not present to possibly affect detection of expression of the disclosed sequence(s). Such contamination is present where a biopsy is used to generate gene expression profiles. However, analysis of differential gene expression and correlation to ER+ breast cancer outcomes with both isolated and non-isolated samples, as described herein, increases the confidence level of the disclosed sequences as capable of having significant predictive power with either type of sample.
While the present invention is described mainly in the context of human breast cancer, it may be practiced in the context of breast cancer of any animal known to be potentially afflicted by breast cancer. Preferred animals for the application of the present invention are mammals, particularly those important to agricultural applications (such as, but not limited to, cattle, sheep, horses, and other “farm animals”), animal models of breast cancer, and animals for human companionship (such as, but not limited to, dogs and cats).
The above aspects and embodiments of the invention may be applied equally with respect to use of more than one “antiestrogen” agent against breast cancer. In the case of a combination of agents, any combination of more than one SERM, SERD, or AI may be used in place of TAM or another “antiestrogen” agent against breast cancer. Aromatase is an enzyme that provides a major source of estrogen in body tissues including the breast, liver, muscle and fat. Without being bound by theory, and solely provided to assist in a better understanding of the invention, AIs are understood to function in a manner comparable to TAM and other “antiestrogen” agents against breast cancer, which are thought to act as antagonists of estrogen receptor in breast tissues and thus as against breast cancer. AIs may be either nonsteroidal or steroidal agents. Examples of the former, which inhibit aromatase via the heme prosthetic group) include, but are not limited to, anastrozole (arimidex), letrozole (femara), and vorozole (rivisor), which have been used or contemplated as treatments for metastatic breast cancer. Examples of steroidal AIs, which inactivate aromatase, include, but are not limited to, exemestane (aromasin), androstenedione, and formestane (lentaron).
Other forms of therapy to reduce estrogen levels include surgical or chemical ovarian ablation. The former is physical removal of the ovaries while the latter is the use of agents to block ovarian production of estrogen. One non-limiting example of the latter are agonists of gonadotropin releasing hormone (GnRH), such as goserelin (zoladex). Of course the instant invention may also be practiced with these therapies in place of treatment with one or more “antiestrogen” agent against breast cancer.
The invention disclosed herein is based in part on the performance of a genome-wide microarray analysis of hormone receptor-positive invasive breast tumors from 60 patients treated with adjuvant tamoxifen alone, leading to the identification of a two-gene expression ratio that is highly predictive of clinical outcome. This expression ratio, which is readily adapted to PCR-based analysis of standard paraffin-embedded clinical specimens, was validated in an independent set of patients as described below.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows receiver operating characteristic (ROC) analyses of IL17BR, HOXB13, and CACNAID expression levels as predictors of breast cancer outcomes in whole tissue sections (top 3 graphs) and laser microdissected cells (bottom 3 graphs). AUC refers to area under the curve.

FIG. 2 contains six parts relating to the validation of a ratio of HOXB13 expression to IL17BR expression as an indicator of responsiveness, or lack thereof, to TAM. Parts a and b show the results of gene expression analysis of HOXB13 and IL17BR sequences by Q-PCR in both Responder and Non-responder samples. Plots of the Responder and Non-responder training and validation data sets are shown in Parts c and d, where “0” indicates Responder datapoints in both and “1” indicates Non-responder datapoints in both. Parts e and f show plots of the Responder and Non-responder training and validation data sets as a function of survival, where the upper line in each Part represents the Responders and the lower line represents the Non-responders.

MODES OF PRACTICING THE INVENTION

Definitions of terms as used herein:
A gene expression “pattern” or “profile” or “signature” refers to the relative expression of genes correlated with responsiveness to treatment of ER+ breast cancer with TAM or another “antiestrogen” agent against breast cancer. Responsiveness or lack thereof may be expressed as survival outcomes which are correlated with an expression “pattern” or “profile” or “signature” that is able to distinguish between, and predict, said outcomes.
A “selective estrogen receptor modulator” or SERM is an “antiestrogen” agent that in some tissues act like estrogens (agonist) but block estrogen action in other tissues (antagonist). A “selective estrogen receptor downregulators” (or “SERD” s) or “pure” antiestrogens includes agents which block estrogen activity in all tissues. See Howell et al. (Best Bractice & Res. Clin. Endocrinol. Metab. 18(1):47-66, 2004). Preferred SERMs of the invention are those that are antagonists of estrogen in breast tissues and cells, including those of breast cancer. Non-limiting examples of such include TAM, raloxifene, GW5638, and ICI 182,780. The possible mechanisms of action by various SERMs have been reviewed (see for example Jordan et al., 2003, Breast Cancer Res. 5:281-283; Hall et al., 2001, J. Biol. Chem. 276(40):36869-36872; Dutertre et al. 2000, J. Pharmacol. Exp. Therap. 295(2):431-437; and Wijayaratne et al., 1999, Endocrinology 140(12):5828-5840). Other non-limiting examples of SERMs in the context of the invention include triphenylethylenes, such as tamoxifen, GW5638, TAT-59, clomiphene, toremifene, droloxifene, and idoxifene; benzothiophenes, such as arzoxiphene (LY353381 or LY353381-HCl); benzopyrans, such as EM-800; naphthalenes, such as CP-336,156; and ERA-923.
Non-limiting examples of SERD or “pure” antiestrogens include agents such as ICI 182,780 (fulvestrant or faslodex) or the oral analogue SR16243 and ZK 191703 as well as aromatase inhibitors and chemical ovarian ablation agents as described herein.
Other agents encompassed by SERM as used herein include progesterone receptor inhibitors and related drugs, such as progestomimetics like medroxyprogesterone acetate, megace, and RU-486; and peptide based inhibitors of ER action, such as LH-RH analogs (leuprolide, zoladex, [D-Trp6]LH-RH), somatostatin analogs, and LXXLL motif mimics of ER as well as tibolone and resveratrol. As noted above, preferred SERMs of the invention are those that are antagonist of estrogen in breast tissues and cells, including those of breast cancer. Non-limiting examples of preferred SERMs include the actual or contemplated metabolites (in vivo) of any SERM, such as, but not limited to, 4-hydroxytamoxifen (metabolite of tamoxifen), EM652 (or SCH 57068 where EM-800 is a prodrug of EM-652), and GW7604 (metabolite of GW5638). See Willson et al. (1997, Endocrinology 138(9):3901-3911) and Dauvois et al. (1992, Proc. Nat'l. Acad. Sci., USA 89:4037-4041) for discussions of some specific SERMs.
Other preferred SERMs are those that produce the same relevant gene expression profile as tamoxifen or 4-hydroxytamoxifen. One example of means to identify such SERMs is provided by Levenson et al. (2002, Cancer Res. 62:4419-4426).
A “gene” is a polynucleotide that encodes a discrete product, whether RNA or proteinaceous in nature. It is appreciated that more than one polynucleotide may be capable of encoding a discrete product. The term includes alleles and polymorphisms of a gene that encodes the same product, or a functionally associated (including gain, loss, or modulation of function) analog thereof, based upon chromosomal location and ability to recombine during normal mitosis.
A “sequence” or “gene sequence” as used herein is a nucleic acid molecule or polynucleotide composed of a discrete order of nucleotide bases. The term includes the ordering of bases that encodes a discrete product (i.e. “coding region”), whether RNA or proteinaceous in nature, as well as the ordered bases that precede or follow a “coding region”. Non-limiting examples of the latter include 5′ and 3′ untranslated regions of a gene. It is appreciated that more than one polynucleotide may be capable of encoding a discrete product. It is also appreciated that alleles and polymorphisms of the disclosed sequences may exist and may be used in the practice of the invention to identify the expression level(s) of the disclosed sequences or the allele or polymorphism. Identification of an allele or polymorphism depends in part upon chromosomal location and ability to recombine during mitosis.
The terms “correlate” or “correlation” or equivalents thereof refer to an association between expression of one or more genes and a physiological response of a breast cancer cell and/or a breast cancer patient in comparison to the lack of the response. A gene may be expressed at higher or lower levels and still be correlated with responsiveness, non-responsiveness or breast cancer survival or outcome. The invention provides for the correlation between increases in expression of IL17BR and CACNA1D sequences and responsiveness of ER+ breast cells to TAM or another “antiestrogen” agent against breast cancer. Thus increases are indicative of responsiveness. Conversely, the lack of increases, including unchanged expression levels, are indicators of non-responsiveness. Similarly, the invention provides for the correlation between decreases in expression of HOXB13 sequences and responsiveness of ER+ breast cells to TAM or another SERM. Thus decreases are indicative of responsiveness while the lack of decreases, including unchanged expression levels, are indicators of non-responsiveness. Increases and decreases may be readily expressed in the form of a ratio between expression in a non-normal cell and a normal cell such that a ratio of one (1) indicates no difference while ratios of two (2) and one-half indicate twice as much, and half as much, expression in the non-normal cell versus the normal cell, respectively. Expression levels can be readily determined by quantitative methods as described below.
For example, increases in IL17BR, CACNA1D, or HOXB13 expression can be indicated by ratios of or about 1.1, of or about 1.2, of or about 1.3, of or about 1.4, of or about 1.5, of or about 1.6, of or about 1.7, of or about 1.8, of or about 1.9, of or about 2, of or about 2.5, of or about 3, of or about 3.5, of or about 4, of or about 4.5, of or about 5, of or about 5.5, of or about 6, of or about 6.5, of or about 7, of or about 7.5, of or about 8, of or about 8.5, of or about 9, of or about 9.5, of or about 10, of or about 15, of or about 20, of or about 30, of or about 40, of or about 50, of or about 60, of or about 70, of or about 80, of or about 90, of or about 100, of or about 150, of or about 200, of or about 300, of or about 400, of or about 500, of or about 600, of or about 700, of or about 800, of or about 900, or of or about 1000. A ratio of 2 is a 100% (or a two-fold) increase in expression. Decreases in IL17BR, CACNA1D, or HOXB13 expression can be indicated by ratios of or about 0.9, of or about 0.8, of or about 0.7, of or about 0.6, of or about 0.5, of or about 0.4, of or about 0.3, of or about 0.2, of or about 0.1, of or about 0.05, of or about 0.01, of or about 0.005, of or about 0.001, of or about 0.0005, of or about 0.0001, of or about 0.00005, of or about 0.00001, of or about 0.000005, or of or about 0.000001.
For a given phenotype, a ratio of the expression of a gene sequence expressed at increased levels in correlation with the phenotype to the expression of a gene sequence expressed at decreased levels in correlation with the phenotype may also be used as an indicator of the phenotype. As a non-limiting example, the phenotype of non-responsiveness to tamoxifen treatment of breast cancer is correlated with increased expression of HOXB13 as well as decreased expression of IL17BR and CACNA1D. Therefore, a ratio of the expression levels of HOXB13 to IL17BR (or CACNA1D) may be used as an indicator of non-responsiveness.
A “polynucleotide” is a polymeric form of nucleotides of any length, either ribonucleotides or deoxyribonucleotides. This term refers only to the primary structure of the molecule. Thus, this term includes double- and single-stranded DNA and RNA. It also includes known types of modifications including labels known in the art, methylation, “caps”, substitution of one or more of the naturally occurring nucleotides with an analog, and intemucleotide modifications such as uncharged linkages (e.g., phosphorothioates, phosphorodithioates, etc.), as well as unmodified forms of the polynucleotide.
The term “amplify” is used in the broad sense to mean creating an amplification product can be made enzymatically with DNA or RNA polymerases. “Amplification,” as used herein, generally refers to the process of producing multiple copies of a desired sequence, particularly those of a sample. “Multiple copies” mean at least 2 copies. A “copy” does not necessarily mean perfect sequence complementarity or identity to the template sequence. Methods for amplifying mRNA are generally known in the art, and include reverse transcription PCR (RT-PCR) and those described in U.S. patent application Ser. No. 10/062,857 (filed on Oct. 25, 2001), as well as U.S. Provisional Patent Applications 60/298,847 (filed Jun. 15, 2001) and 60/257,801 (filed Dec. 22, 2000), all of which are hereby incorporated by reference in their entireties as if fully set forth. Another method which may be used is quantitative PCR (or Q-PCR). Alternatively, RNA may be directly labeled as the corresponding cDNA by methods known in the art.
By “corresponding”, it is meant that a nucleic acid molecule shares a substantial amount of sequence identity with another nucleic acid molecule. Substantial amount means at least 95%, usually at least 98% and more usually at least 99%, and sequence identity is determined using the BLAST algorithm, as described in Altschul et al. (1990), J. Mol. Biol. 215:403-410 (using the published default setting, i.e. parameters w=4, t=17).
A “microarray” is a linear or two-dimensional or three dimensional (and solid phase) array of preferably discrete regions, each having a defined area, formed on the surface of a solid support such as, but not limited to, glass, plastic, or synthetic membrane. The density of the discrete regions on a microarray is determined by the total numbers of immobilized polynucleotides to be detected on the surface of a single solid phase support, preferably at least about 50/cm², more preferably at least about 100/cm², even more preferably at least about 500/cm², but preferably below about 1,000/cm². Preferably, the arrays contain less than about 500, about 1000, about 1500, about 2000, about 2500, or about 3000 immobilized polynucleotides in total. As used herein, a DNA microarray is an array of oligonucleotides or polynucleotides placed on a chip or other surfaces used to hybridize to amplified or cloned polynucleotides from a sample. Since the position of each particular group of primers in the array is known, the identities of a sample polynucleotides can be determined based on their binding to a particular position in the microarray. As an alternative to the use of a microarray, an array of any size may be used in the practice of the invention, including an arrangement of one or more position of a two-dimensional or three dimensional arrangement in a solid phase to detect expression of a single gene sequence.
Because the invention relies upon the identification of genes that are over- or under-expressed, one embodiment of the invention involves determining expression by hybridization of mRNA, or an amplified or cloned version thereof, of a sample cell to a polynucleotide that is unique to a particular gene sequence. Preferred polynucleotides of this type contain at least about 16, at least about 18, at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, or at least about 32 consecutive basepairs of a gene sequence that is not found in other gene sequences. The term “about” as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Even more preferred are polynucleotides of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, at least or about 400, at least or about 450, or at least or about 500 consecutive bases of a sequence that is not found in other gene sequences. The term “about” as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value. Longer polynucleotides may of course contain minor mismatches (e.g. via the presence of mutations) which do not affect hybridization to the nucleic acids of a sample. Such polynucleotides may also be referred to as polynucleotide probes that are capable of hybridizing to sequences of the genes, or unique portions thereof, described herein. Such polynucleotides may be labeled to assist in their detection. Preferably, the sequences are those of mRNA encoded by the genes, the corresponding cDNA to such mRNAs, and/or amplified versions of such sequences. In preferred embodiments of the invention, the polynucleotide probes are immobilized on an array, other solid support devices, or in individual spots that localize the probes.
In another embodiment of the invention, all or part of a disclosed sequence may be amplified and detected by methods such as the polymerase chain reaction (PCR) and variations thereof, such as, but not limited to, quantitative PCR (Q-PCR), reverse transcription PCR (RT-PCR), and real-time PCR (including as a means of measuring the initial amounts of mRNA copies for each sequence in a sample), optionally real-time RT-PCR or real-time Q-PCR. Such methods would utilize one or two primers that are complementary to portions of a disclosed sequence, where the primers are used to prime nucleic acid synthesis. The newly synthesized nucleic acids are optionally labeled and may be detected directly or by hybridization to a polynucleotide of the invention. The newly synthesized nucleic acids may be contacted with polynucleotides (containing sequences) of the invention under conditions which allow for their hybridization. Additional methods to detect the expression of expressed nucleic acids include RNAse protection assays, including liquid phase hybridizations, and in situ hybridization of cells.
Alternatively, and in yet another embodiment of the invention, gene expression may be determined by analysis of expressed protein in a cell sample of interest by use of one or more antibodies specific for one or more epitopes of individual gene products (proteins), or proteolytic fragments thereof, in said cell sample or in a bodily fluid of a subject. The cell sample may be one of breast cancer epithelial cells enriched from the blood of a subject, such as by use of labeled antibodies against cell surface markers followed by fluorescence activated cell sorting (FACS). Such antibodies are preferably labeled to permit their easy detection after binding to the gene product. Detection methodologies suitable for use in the practice of the invention include, but are not limited to, immunohistochemistry of cell containing samples or tissue, enzyme linked immunosorbent assays (ELISAs) including antibody sandwich assays of cell containing tissues or blood samples, mass spectroscopy, and immuno-PCR.
The term “label” refers to a composition capable of producing a detectable signal indicative of the presence of the labeled molecule. Suitable labels include radioisotopes, nucleotide chromophores, enzymes, substrates, fluorescent molecules, chemiluminescent moieties, magnetic particles, bioluminescent moieties, and the like. As such, a label is any composition detectable by spectroscopic, photochemical, biochemical, immunochemical, electrical, optical or chemical means.
The term “support” refers to conventional supports such as beads, particles, dipsticks, fibers, filters, membranes and silane or silicate supports such as glass slides.
As used herein, a “breast tissue sample” or “breast cell sample” refers to a sample of breast tissue or fluid isolated from an individual suspected of being afflicted with, or at risk of developing, breast cancer. Such samples are primary isolates (in contrast to cultured cells) and may be collected by any non-invasive or minimally invasive means, including, but not limited to, ductal lavage, fine needle aspiration, needle biopsy, the devices and methods described in U.S. Pat. No. 6,328,709, or any other suitable means recognized in the art. Alternatively, the “sample” may be collected by an invasive method, including, but not limited to, surgical biopsy.
“Expression” and “gene expression” include transcription and/or translation of nucleic acid material.
As used herein, the term “comprising” and its cognates are used in their inclusive sense; that is, equivalent to the term “including” and its corresponding cognates.
Conditions that “allow” an event to occur or conditions that are “suitable” for an event to occur, such as hybridization, strand extension, and the like, or “suitable” conditions are conditions that do not prevent such events from occurring. Thus, these conditions permit, enhance, facilitate, and/or are conducive to the event. Such conditions, known in the art and described herein, depend upon, for example, the nature of the nucleotide sequence, temperature, and buffer conditions. These conditions also depend on what event is desired, such as hybridization, cleavage, strand extension or transcription.
Sequence “mutation,” as used herein, refers to any sequence alteration in the sequence of a gene disclosed herein interest in comparison to a reference sequence. A sequence mutation includes single nucleotide changes, or alterations of more than one nucleotide in a sequence, due to mechanisms such as substitution, deletion or insertion. Single nucleotide polymorphism (SNP) is also a sequence mutation as used herein. Because the present invention is based on the relative level of gene expression, mutations in non-coding regions of genes as disclosed herein may also be assayed in the practice of the invention.
“Detection” includes any means of detecting, including direct and indirect detection of gene expression and changes therein. For example, “detectably less” products may be observed directly or indirectly, and the term indicates any reduction (including the absence of detectable signal). Similarly, “detectably more” product means any increase, whether observed directly or indirectly.
Increases and decreases in expression of the disclosed sequences are defined in the following terms based upon percent or fold changes over expression in normal cells. Increases may be of 10, 20, 30, 40, 50, 60, 70, 80, 90, 100, 120, 140, 160, 180, or 200% relative to expression levels in normal cells. Alternatively, fold increases may be of 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, or 10 fold over expression levels in normal cells. Decreases may be of 10, 20, 30, 40, 50, 55, 60, 65, 70, 75, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 99 or 100% relative to expression levels in normal cells.
Unless defined otherwise all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this invention belongs.

Embodiments of the Invention

In a first aspect, the disclosed invention relates to the identification and use of gene expression patterns (or profiles or “signatures”) which discriminate between (or are correlated with) breast cancer survival in a subject treated with tamoxifen (TAM) or another “antiestrogen” agent against breast cancer. Such patterns may be determined by the methods of the invention by use of a number of reference cell or tissue samples, such as those reviewed by a pathologist of ordinary skill in the pathology of breast cancer, which reflect breast cancer cells as opposed to normal or other non-cancerous cells. The outcomes experienced by the subjects from whom the samples may be correlated with expression data to identify patterns that correlate with the outcomes following treatment with TAM or another “antiestrogen” agent against breast cancer. Because the overall gene expression profile differs from person to person, cancer to cancer, and cancer cell to cancer cell, correlations between certain cells and genes expressed or underexpressed may be made as disclosed herein to identify genes that are capable of discriminating between breast cancer outcomes.
The present invention may be practiced with any number of the genes believed, or likely to be, differentially expressed with respect to breast cancer outcomes, particularly in cases of ER+ breast cancer. The identification may be made by using expression profiles of various homogenous breast cancer cell populations, which were isolated by microdissection, such as, but not limited to, laser capture microdissection (LCM) of 100-1000 cells. The expression level of each gene of the expression profile may be correlated with a particular outcome. Alternatively, the expression levels of multiple genes may be clustered to identify correlations with particular outcomes.
Genes with significant correlations to breast cancer survival when the subject is treated with tamoxifen may be used to generate models of gene expressions that would maximally discriminate between outcomes where a subject responds to treatment with tamoxifen or another “antiestrogen” agent against breast cancer and outcomes where the treatment is not successful. Alternatively, genes with significant correlations may be used in combination with genes with lower correlations without significant loss of ability to discriminate between outcomes. Such models may be generated by any appropriate means recognized in the art, including, but not limited to, cluster analysis, supported vector machines, neural networks or other algorithm known in the art. The models are capable of predicting the classification of a unknown sample based upon the expression of the genes used for discrimination in the models. “Leave one out” cross-validation may be used to test the performance of various models and to help identify weights (genes) that are uninformative or detrimental to the predictive ability of the models. Cross-validation may also be used to identify genes that enhance the predictive ability of the models.
The gene(s) identified as correlated with particular breast cancer outcomes relating to tamoxifen treatment by the above models provide the ability to focus gene expression analysis to only those genes that contribute to the ability to identify a subject as likely to have a particular outcome relative to another. The expression of other genes in a breast cancer cell would be relatively unable to provide information concerning, and thus assist in the discrimination of, a breast cancer outcome.
As will be appreciated by those skilled in the art, the models are highly useful with even a small set of reference gene expression data and can become increasingly accurate with the inclusion of more reference data although the incremental increase in accuracy will likely diminish with each additional datum. The preparation of additional reference gene expression data using genes identified and disclosed herein for discriminating between different outcomes in breast cancer following treatment with tamoxifen or another “antiestrogen” agent against breast cancer is routine and may be readily performed by the skilled artisan to permit the generation of models as described above to predict the status of an unknown sample based upon the expression levels of those genes.
To determine the (increased or decreased) expression levels of genes in the practice of the present invention, any method known in the art may be utilized. In one preferred embodiment of the invention, expression based on detection of RNA which hybridizes to the genes identified and disclosed herein is used. This is readily performed by any RNA detection or amplification+detection method known or recognized as equivalent in the art such as, but not limited to, reverse transcription-PCR, the methods disclosed in U.S. patent application Ser. No. 10/062,857 (filed on Oct. 25, 2001) as well as U.S. Provisional Patent Applications 60/298,847 (filed Jun. 15, 2001) and 60/257,801 (filed Dec. 22, 2000), and methods to detect the presence, or absence, of RNA stabilizing or destabilizing sequences.
Alternatively, expression based on detection of DNA status may be used. Detection of the DNA of an identified gene as methylated or deleted may be used for genes that have decreased expression in correlation with a particular breast cancer outcome. This may be readily performed by PCR based methods known in the art, including, but not limited to, Q-PCR. Conversely, detection of the DNA of an identified gene as amplified may be used for genes that have increased expression in correlation with a particular breast cancer outcome. This may be readily performed by PCR based, fluorescent in situ hybridization (FISH) and chromosome in situ hybridization (CISH) methods known in the art.
Expression based on detection of a presence, increase, or decrease in protein levels or activity may also be used. Detection may be performed by any immunohistochemistry (IHC) based, blood based (especially for secreted proteins), antibody (including autoantibodies against the protein) based, exfoliate cell (from the cancer) based, mass spectroscopy based, and image (including used of labeled ligand) based method known in the art and recognized as appropriate for the detection of the protein. Antibody and image based methods are additionally useful for the localization of tumors after determination of cancer by use of cells obtained by a non-invasive procedure (such as ductal lavage or fine needle aspiration), where the source of the cancerous cells is not known. A labeled antibody or ligand may be used to localize the carcinoma(s) within a patient or to assist in the enrichment of exfoliated cancer cells from a bodily fluid.
A preferred embodiment using a nucleic acid based assay to determine expression is by immobilization of one or more sequences of the genes identified herein on a solid support, including, but not limited to, a solid substrate as an array or to beads or bead based technology as known in the art. Alternatively, solution based expression assays known in the art may also be used. The immobilized gene(s) may be in the form of polynucleotides that are unique or otherwise specific to the gene(s) such that the polynucleotide would be capable of hybridizing to a DNA or RNA corresponding to the gene(s). These polynucleotides may be the full length of the gene(s) or be short sequences of the genes (up to one nucleotide shorter than the full length sequence known in the art by deletion from the 5′ or 3′ end of the sequence) that are optionally minimally interrupted (such as by mismatches or inserted non-complementary basepairs) such that hybridization with a DNA or RNA corresponding to the gene(s) is not affected. Preferably, the polynucleotides used are from the 3′ end of the gene, such as within about 350, about 300, about 250, about 200, about 150, about 100, or about 50 nucleotides from the polyadenylation signal or polyadenylation site of a gene or expressed sequence. Polynucleotides containing mutations relative to the sequences of the disclosed genes may also be used so long as the presence of the mutations still allows hybridization to produce a detectable signal.
The immobilized gene(s) may be used to determine the state of nucleic acid samples prepared from sample breast cell(s) for which the outcome of the sample's subject (e.g. patient from whom the sample is obtained) is not known or for confirmation of an outcome that is already assigned to the sample's subject. Without limiting the invention, such a cell may be from a patient with ER+ or ER− breast cancer. The immobilized polynucleotide(s) need only be sufficient to specifically hybridize to the corresponding nucleic acid molecules derived from the sample under suitable conditions. While even a single correlated gene sequence may to able to provide adequate accuracy in discriminating between two breast cancer outcomes, two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, ten or more, or eleven or more of the genes identified herein may be used as a subset capable of discriminating may be used in combination to increase the accuracy of the method. The invention specifically contemplates the selection of more than one, two or more, three or more, four or more, five or more, six or more, seven or more, eight or more, nine or more, ten or more, or eleven or more of the genes disclosed in the tables and figures herein for use as a subset in the identification of breast cancer survival outcome.
Of course 1 or more, 2 or more, 3 or more, 4 or more, 5 or more, 6 or more, 7 or more, 8 or more, 9 or more, or all the genes provided in Tables 2 and/or 3 below may be used. “Accession” as used in the context of the Tables herein as well as the present invention refers to the GenBank accession number of a sequence of each gene, the sequences of which are hereby incorporated by reference in their entireties as they are available from GenBank as accessed on the filing date of the present application. P value refers to values assigned as described in the Examples below. The indications of “E-xx” where “xx” is a two digit number refers to alternative notation for exponential figures where “E-xx” is “10^−xx”. Thus in combination with the numbers to the left of “E-xx”, the value being represented is the numbers to the left times 10^−xx. “Description” as used in the Tables provides a brief identifier of what the sequence/gene encodes.
Genes with a correlation identified by a p value below or about 0.02, below or about 0.01, below or about 0.005, or below or about 0.001 are preferred for use in the practice of the invention. The present invention includes the use of gene(s) the expression of which identify different breast cancer outcomes after treatment with TAM or another “antiestrogen” agent against breast cancer to permit simultaneous identification of breast cancer survival outcome of a patient based upon assaying a breast cancer sample from said patient.
In a second aspect, the present invention relates to the identification and use of three sets of sequences for the determination of responsiveness of ER+ breast cancer to treatment with TAM or another “antiestrogen” agent against breast cancer. The differential expression of these sequences in breast cancer relative to normal breast cells is used to predict responsiveness to TAM or another “antiestrogen” agent against breast cancer in a subject.
To identify gene expression patterns in ER positive, early stage invasive breast cancers that might predict response to hormonal therapy, microarray gene expression analysis was performed on tumors from 60 women uniformly treated with adjuvant tamoxifen alone. These patients were identified from a total of 103 ER+ early stage cases presenting to Massachusetts General Hospital between 1987 and 1997, from whom tumor specimens were snap frozen and for whom minimal 5 year follow-up was available (see Table 1 for details). Within this cohort, 28 (46%) women developed distant metastasis with a median time to recurrence of 4 years (“tamoxifen non-responders”) and 32 (54%) women remained disease-free with median follow-up of 10 years (“tamoxifen responders”). Responders were matched with non-responder cases with respect to TNM staging (see Singletary, S. E. et al. “Revision of the American Joint Committee on Cancer staging system for breast cancer.” J Clin Oncol 20, 3628-36 (2002)) and tumor grade (see Dalton, L. W. et al. “Histologic grading of breast cancer: linkage of patient outcome with level of pathologist agreement.” Mod Pathol 13, 730-5. (2000)).
Previous studies linking gene expression profiles to clinical outcome in breast cancer have demonstrated that the potential for distant metastasis and overall survival probability may be predictable through biological characteristics of the primary tumor at the time of diagnosis (see Huang, E. et al. “Gene expression predictors of breast cancer outcomes.” Lancet 361, 1590-6 (2003); Sorlie, T. et al. “Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.” Proc Natl Acad Sci USA 98:10869-74 (2001); Sorlie, T. et al. “Repeated observation of breast tumor subtypes in independent gene expression data sets.” Proc Natl Acad Sci USA 100, 8418-23 (2003); Sotiriou, C. et al. “Breast cancer classification and prognosis based on gene expression profiles from a population-based study.” Proc Natl Acad Sci USA 100, 10393-8 (2003); van 't Veer, L. J. et al. “Gene expression profiling predicts clinical outcome of breast cancer.” Nature 415, 530-6 (2002); and van de Vijver, M. J. et al. “A gene-expression signature as a predictor of survival in breast cancer.” N Engl J Med 347, 1999-2009 (2002)). In particular, a 70-gene expression signature has proven to be a strong prognostic factor, out-performing all known clinicopathological parameters. However, in those studies patients either received no adjuvant therapy (van 't Veer, L. J. et al. Nature 2002) or were treated non-uniformly with hormonal and chemotherapeutic regimens (Huang, E. et al.; Sorlie, T. et al.; Sorlie, T. et al.; Sotiriou, C. et al.; and van de Vijver, M. J. et al. N Engl J Med 2002). Patients with ER+ early-stage breast cancer treated with tamoxifen alone, such as the cohort studied here, represent only a subset of the population tested with the 70-gene signature. Of note, 61 of the genes in the 70-gene signature were present on the microarray used as described below, but no significant association with clinical outcome was observed in the defined subset of patients.
In comparison with existing biomarkers, including ESR1, PGR, ERBB2 and EGFR, three sets of gene sequences disclosed herein are significantly more predictive of responsiveness to TAM treatment. Multivariate analysis indicated that these three genes were significant predictors of clinical outcome independent of tumor size, nodal status and tumor grade. ER and progesterone receptor (PR) expression have been the major clinicopathological predictors for response to TAM. However, up to 40% of ER+ tumors fail to respond or develop resistance to TAM. The invention thus provides for the use of the identified biomarkers to allow better patient management by identifying patients who are more likely to benefit from TAM or other endocrine therapy and those who are likely to develop resistance and tumor recurrence.
As noted herein, the sequences(s) identified by the present invention are expressed in correlation with ER+ breast cancer cells. For example, IL17BR, identified by I.M.A.G.E. Consortium Clusters NM_018725 and NM_172234 (“The I.M.A.G.E. Consortium: An Integrated Molecular Analysis of Genomes and their Expression,” Lennon et al., 1996, Genomics 33:151-152; see also image.llnl.gov) has been found to be useful in predicting responsiveness to TAM treatment.
In preferred embodiments of the invention, any sequence, or unique portion thereof, of the IL17BR sequences of the cluster, as well as the UniGene Homo sapiens cluster Hs.5470, may be used. Similarly, any sequence encoding all or a part of the protein encoded by any IL17BR sequence disclosed herein may be used. Consensus sequences of I.M.A.G.E. Consortium clusters are as follows, with the assigned coding region (ending with a termination codon) underlined and preceded by the 5′ untranslated and/or non-coding region and followed by the 3′ untranslated and/or non-coding region:

(consensus sequence for IL17BR, transcript variant 1 dentified as NM_018725
or NM_018725.2)
SEQ ID NO: 1
agcgcagcgt gcgggtggcc tggatcccgc gcagtggccc ggcgatgtcg ctcgtgctgc

taagcctggc cgcgctgtgc aggagcgccg taccccgaga gccgaccgtt caatgtggct

ctgaaactgg gccatctcca gagtggatgc tacaacatga tctaatcccc ggagacttga

gggacctccg agtagaacct gttacaacta gtgttgcaac aggggactat tcaattttga

tgaatgtaag ctgggtactc cgggcagatg ccagcatccg cttgttgaag gccaccaaga

tttgtgtgac gggcaaaagc aacttccagt cctacagctg tgtgaggtgc aattacacag

aggccttcca gactcagacc agaccctctg gtggtaaatg gacattttcc tacatcggct

tccctgtaga gctgaacaca gtctatttca ttggggccca taatattcct aatgcaaata

tgaatgaaga tggcccttcc atgtctgtga atttcacctc accaggctgc ctagaccaca

taatgaaata taaaaaaaag tgtgtcaagg ccggaagcct gtgggatccg aacatcactg

cttgtaagaa gaatgaggag acagtagaag tgaacttcac aaccactccc ctgggaaaca

gatacatggc tcttatccaa cacagcacta tcatcgggtt ttctcaggtg tttgagccac

accagaagaa acaaacgcga gcttcagtgg tgattccagt gactggggat agtgaaggtg

ctacggtgca gctgactcca tattttccta cttgtggcag cgactgcatc cgacataaag

gaacagttgt gctctgccca caaacaggcg tccctttccc tctggataac aacaaaagca

agccgggagg ctggctgcct ctcctcctgc tgtctctgct ggtggccaca tgggtgctgg

tggcagggat ctatctaatg tggaggcacg aaaggatcaa gaagacttcc ttttctacca

ccacactact gccccccatt aaggttcttg tggtttaccc atctgaaata tgtttccatc

acacaatttg ttacttcact gaatttcttc aaaaccattg cagaagtgag gtcatccttg

aaaagtggca gaaaaagaaa atagcagaga tgggtccagt gcagtggctt gccactcaaa

agaaggcagc agacaaagtc gtcttccttc tttccaatga cgtcaacagt gtgtgcgatg

gtacctgtgg caagagcgag ggcagtccca gtgagaactc tcaagacctc ttcccccttg

cctttaacct tttctgcagt gatctaagaa gccagattca tctgcacaaa tacgtggtgg

tctactttag agagattgat acaaaagacg attacaatgc tctcagtgtc tgccccaagt

accacctcat gaaggatgcc actgctttct gtgcagaact tctccatgtc aagcagcagg

tgtcagcagg aaaaagatca caagcctgcc acgatggctg ctgctccttg tagcccaccc

atgagaagca agagacctta aaggcttcct atcccaccaa ttacagggaa aaaacgtgtg

atgatcctga agcttactat gcagcctaca aacagcctta gtaattaaaa cattttatac

caataaaatt ttcaaatatt gctaactaat gtagcattaa ctaacgattg gaaactacat

ttacaacttc aaagctgttt tatacataga aatcaattac agttttaatt gaaaactata

accattttga taatgcaaca ataaagcatc ttcagccaaa catctagtct tccatagacc

atgcattgca gtgtacccag aactgtttag ctaatattct atgtttaatt aatgaatact

aactctaaga acccctcact gattcactca atagcatctt aagtgaaaaa ccttctatta

catgcaaaaa atcattgttt ttaagataac aaaagtaggg aataaacaag ctgaacccac

ttttaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa

(consensus sequence for IL17BR, transcript variant 2, identified as
NM_172234 or NM_172234.1)
SEQ ID NO: 2
agcgcagcgt gcgggtggcc tggatcccgc gcagtggccc ggcgatgtcg ctcgtgctgc

taagcctggc cgcgctgtgc aggagcgccg taccccgaga gccgaccgtt caatgtggct

ctgaaactgg gccatctcca gagtggatgc tacaacatga tctaatcccc ggagacttga

gggacctccg agtagaacct gttacaacta gtgttgcaac aggggactat tcaattttga

tgaatgtaag ctgggtactc cgggcagatg ccagcatccg cttgttgaag gccaccaaga

tttgtgtgac gggcaaaagc aacttccagt cctacagctg tgtgaggtgc aattacacag

aggccttcca gactcagacc agaccctctg gtggtaaatg gacattttcc tacatcggct

tccctgtaga gctgaacaca gtctatttca ttggggccca taatattcct aatgcaaata

tgaatgaaga tggcccttcc atgtctgtga atttcacctc accaggctgc ctagaccaca

taatgaaata taaaaaaaag tgtgtcaagg ccggaagcct gtgggatccg aacatcactg

cttgtaagaa gaatgaggag acagtagaag tgaacttcac aaccactccc ctgggaaaca

gatacatggc tcttatccaa cacagcacta tcatcgggtt ttctcaggtg tttgagccac

accagaagaa acaaacgcga gcttcagtgg tgattccagt gactggggat agtgaaggtg

ctacggtgca ggtaaagttc agtgagctgc tctggggagg gaagggacat agaagactgt

tccatcattc attgctttta aggatgagtt ctctcttgtc aaatgcactt ctgccagcag

acaccagtta agtggcgttc atgggggctc tttcgctgca gcctccaccg tgctgaggtc

aggaggccga cgtggcagtt gtggtccctt ttgcttgtat taatggctgc tgaccttcca

aagcactttt tattttcatt ttctgtcaca gacactcagg gatagcagta ccattttact

tccgcaagcc tttaactgca agatgaagct gcaaagggtt tgaaatggga aggtttgagt

tccaggcagc gtatgaactc tggagagggg ctgccagtcc tctctgggcc gcagcggacc

cagctggaac acaggaagtt ggagcagtag gtgctccttc acctctcagt atgtctcttt

caactctagt ttttgaggtg gggacacagg aggtccagtg ggacacagcc actccccaaa

gagtaaggag cttccatgct tcattccctg gcataaaaag tgctcaaaca caccagaggg

ggcaggcacc agccagggta tgatggctac tacccttttc tggagaacca tagacttccc

ttactacagg gacttgcatg tcctaaagca ctggctgaag gaagccaaga ggatcactgc

tgctcctttt ttctagagga aatgtttgtc tacgtggtaa gatatgacct agccctttta

ggtaagcgaa ctggtatgtt agtaacgtgt acaaagttta ggttcagacc ccgggagtct

tgggcacgtg ggtctcgggt cactggtttt gactttaggg ctttgttaca gatgtgtgac

caaggggaaa atgtgcatga caacactaga ggtatgggcg aagccagaaa gaagggaagt

tttggctgaa gtaggagtct tggtgagatt ttgctctgat gcatggtgtg aactttctga

gcctcttgtt tttcctcagc tgactccata ttttcctact tgtggcagcg actgcatccg

acataaagga acagttgtgc tctgcccaca aacaggcgtc cctttccctc tggataacaa

caaaagcaag ccgggaggct ggctgcctct cctcctgctg tctctgctgg tggccacatg

ggtgctggtg gcagggatct atctaatgtg gaggcacgaa aggatcaaga agacttcctt

ttctaccacc acactactgc cccccattaa ggttcttgtg gtttacccat ctgaaatatg

tttccatcac acaatttgtt acttcactga atttcttcaa aaccattgca gaagtgaggt

catccttgaa aagtggcaga aaaagaaaat agcagagatg ggtccagtgc agtggcttgc

cactcaaaag aaggcagcag acaaagtcgt cttccttctt tccaatgacg tcaacagtgt

gtgcgatggt acctgtggca agagcgaggg cagtcccagt gagaactctc aagacctctt

cccccttgcc tttaaccttt tctgcagtga tctaagaagc cagattcatc tgcacaaata

cgtggtggtc tactttagag agattgatac aaaagacgat tacaatgctc tcagtgtctg

ccccaagtac cacctcatga aggatgccac tgctttctgt gcagaacttc tccatgtcaa

gcagcaggtg tcagcaggaa aaagatcaca agcctgccac gatggctgct gctccttgta

gcccacccat gagaagcaag agaccttaaa ggcttcctat cccaccaatt acagggaaaa

aacgtgtgat gatcctgaag cttactatgc agcctacaaa cagccttagt aattaaaaca

ttttatacca ataaaatttt caaatattgc taactaatgt agcattaact aacgattgga

aactacattt acaacttcaa agctgtttta tacatagaaa tcaattacag ttttaattga

aaactataac cattttgata atgcaacaat aaagcatctt cagccaaaca tctagtcttc

catagaccat gcattgcagt gtacccagaa ctgtttagct aatattctat gtttaattaa

tgaatactaa ctctaagaac ccctcactga ttcactcaat agcatcttaa gtgaaaaacc

ttctattaca tgcaaaaaat cattgttttt aagataacaa aagtagggaa taaacaagct

gaacccactt ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa

I.M.A.G.E. Consortium Clone ID numbers and the corresponding GenBank accession numbers of sequences identified as belonging to the I.M.A.G.E. Consortium and UniGene clusters, are listed below. Also included are sequences that are not identified as having a Clone ID number but still identified as being those of IL17BR. The sequences include those of the “sense” and complementary strands sequences corresponding to IL17BR. The sequence of each GenBank accession number is presented in the attached Appendix.


Clone ID numbers	GenBank accession numbers

2985728	AW675096, AW673932, BC000980
5286745	BI602183
5278067	BI458542
5182255	BI823321
924000	AA514396
13566736	BF110326
3195409	BE466508
3576775	BF740045
2772915	AW299271
1368826	AA836217
1744837	AI203628
2285564	AI27783
2217709	AI744263
2103651	AI401622
2419487	AI826949
3125592	BE047352
2284721	AI911549
3643302	BF194822
1646910	AI034244
1647001	AI033911
3323709	BF064177
1419779	AA847767
2205190	AI538624
2295838	AI913613
2461335	AI942234
2130362	AI580483
2385555	AI831909
2283817	AI672344
2525596	AW025192
454687	AA677205
1285273	AA721647
3134106	BF115018
342259	W61238, W61239
1651991	AI032064
2687714	AW236941
3302808	BG057174
2544461	AW058532
122014	T98360, T98361
12139250	AI470845
2133899	AI497731
121300	T96629, T96740
162274	H25975, H25941
3446667	BE539514, BX282554
156864	R74038, R74129
4611491	BG433769
4697316	BG530489
429376	AA007528, AA007529
5112415	BI260259
701357	AA287951, AA287911
121909	T97852, T97745
268037	N40294
1307489	AA809841
1357543	AA832389
48442	H14692
1302619	AA732635
1562857	AA928257
1731938	AI184427
1896025	AI298577
2336350	AI692717
1520997	AA910922
240506	H90761
2258560	AI620122
1569921	AI793318, AA962325, AI733290
6064627	BQ226353
299018	W04890
5500181	BM455231
2484011	BI492426
4746376	BG674622
233783	BX111256
1569921	BX117618
450450	AA682806
1943085	AI202376
2250390	AI658949
4526156	BG403405
3249181	BE673417
2484395	AW021469
30515867	CF455736
2878155	AW339874
4556884	BG399724
3254505	BF475787
3650593	BF437145
233783	H64601
None (mRNA	AF212365, AF208110, AF208111, AF250309,
sequences)	AK095091
None	BM983744, CB305764, BM715988, BM670929,
	BI792416, BI715216, N56060, CB241389,
	AV660618, BX088671, CB154426, CA434589,
	CA412162, CA314073, BF921554, BF920093,
	AV685699, AV650175, BX483104, CD675121,
	BE081436, AW970151, AW837146,
	AW368264, D25960, AV709899, BX431018,
	AL535617, AL525465, BX453536, BX453537,
	AV728945, AV728939, AV727345

In one preferred embodiment, any sequence, or unique portion thereof, of the following IL17BR sequence, identified by AF208111 or AF208111.1, may be used in the practice of the invention.

SEQ ID NO: 3 (sequence for IL17BR):

CGGCGATGTCGCTCGTGCTGATAAGCCTGGCCGCGCTGTGCAGGAGCGC

CGTACCCCGAGAGCCGACCGTTCAATGTGGCTCTGAAACTGGGCCATCT

CCAGAGTGGATGCTACAACATGATCTAATCCCCGGAGACTTGAGGGACC

TCCGAGTAGAACCTGTTACAACTAGTGTTGCAACAGGGGACTATTCAAT

TTTGATGAATGTAAGCTGGGTACTCCGGGCAGATGCCAGCATCCGCTTG

TTGAAGGCCACCAAGATTTGTGTGACGGGCAAAAGCAACTTCCAGTCCT

ACAGCTGTGTGAGGTGCAATTACACAGAGGCCTTCCAGACTCAGACCAG

ACCCTCTGGTGGTAAATGGACATTTTCCTATATCGGCTTCCCTGTAGAG

CTGAACACAGTCTATTTCATTGGGGCCCATAATATTCCTAATGCAAATA

TGAATGAAGATGGCCCTTCCATGTCTGTGAATTTCACCTCACCAGGCTG

CCTAGACCACATAATGAAATATAAAAAAAAGTGTGTCAAGGCCGGAAGC

TGTGGGATCCGAACATCACTGCTTGTAAGAAGAATGAGGAGACAGTAGA

AGTGAACTTCACAACCACTCCCCTGGGAAACAGATACATGGCTCTTATC

CAACACAGCACTATCATCGGGTTTTCTCAGGTGTTTGAGCCACACCAGA

AGAAACAAACGCGAGCTTCAGTGGTGATTCCAGTGACTGGGGATAGTGA

AGGTGCTACGGTGCAGGTAAAGTTCAGTGAGCTGCTCTGGGGAGGGAAG

GGACATAGAAGACTGTTCCATCATTCATTGCTTTTAAGGATGAGTTCTC

TCTTGTCAAATGCACTTCTGCCAGCAGACACCAGTTAAGTGGCGTTCAT

GGGGGTTCTTTCGCTGCAGCCTCCACCGTGCTGAGGTCAGGAGGCCGAC

GTGGCAGTTGTGGTCCCTTTTGCTTGTATTAATGGCTGCTGACCTTCCA

AAGCACTTTTTATTTTCATTTTCTGTCACAGACACTCAGGGATAGCAGT

ACCATTTTACTTCCGCAAGCCTTTAACTGCAAGATGAAGCTGCAAAGGG

TTTGAAATGGGAAGGTTTGAGTTCCAGGCAGCGTATGAACTCTGGAGAG

GGGCTGCCAGTCCTCTCTGGGCCGCAGCGGACCCAGCTGGAACACAGGA

AGTTGGAGCAGTAGGTGCTCCTTCACCTCTCAGTATGTCTCTTTCAACT

CTAGTTTTTGAAGTGGGGACACAGGAAGTCCAGTGGGGACACAGCCACT

CCCCAAAGAATAAGGAACTTCCATGCTTCATTCCCTGGCATAAAAAGTG

NTCAAACACACCAGAGGGGGCAGGCACCAGCCAGGGTATGATGGGTACT

ACCCTTTTCTGGAGAACCATAGACTTCCCTTACTACAGGGACTTGCATG

TCCTAAAGCACTGGCTGAAGGAAGCCAAGAGGATCACTGCTGCTCCTTT

TTTGTAGAGGAAATGTTTGTGTACGTGGTAAGATATGACCTAGCCCTTT

TAGGTAAGCGAACTGGTATGTTAGTAACGTGTACAAAGTTTAGGTTCAG

ACCCCGGGAGTCTTGGGCATGTGGGTCTCGGGTCACTGGTTTTGACTTT

AGGGCTTTGTTACAGATGTGTGACCAAGGGGAAAATGTGCATGACAACA

CTAGAGGTAGGGGCGAAGCCAGAAAGAAGGGAAGTTTTGGCTGAAGTAG

GAGTCTTGGTGAGATTTTGCTGTGATGCATGGTGTGAACTTTCTGAGCC

TCTTGTTTTTCCTCAGCTGACTCCATATTTTCCTACTTGTGGCAGCGAC

TGCATCCGACATAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGTCC

CTTTCCCTCTGGATAACAACAAAAGCAAGCCGGGAGGCTGGCTGCCTCT

CCTCCTGCTGTCTCTGCTGGTGGCCACATGGGTGCTGGTGGCAGGGATC

TATCTAATGTGGAGGCACGAAAGGATCAAGAAGACTTCCTTTTCTACCA

CCACACTACTGCCCCCCATTAAGGTTCTTGTGGTTTACCCATCTGAAAT

ATGTTTCCATCACACAATTTGTTACTTCACTGAATTTCTTCAAAACCAT

TGCAGAAGTGAGGTCATCCTTGAAAAGTGGCAGAAAAAGAAAATAGCAG

AGATGGGTCCAGTGCAGTGGCTTGCCACTCAAAAGAAGGCAGCAGACAA

AGTCGTCTTCCTTCTTTCCAATGACGTCAACAGTGTGTGCGATGGTACC

TGTGGCAAGAGCGAGGGCAGTCCCAGTGAGAACTCTCAAGACCTCTTCC

CCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAAGCCAGATTCATCT

GCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACGAT

TACAATGCTCTCAGTGTCTGCCCCAAGTACCACTTCATGAAGGATGCCA

CTGCTTTCTGTGCAGAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGG

AAAAAGATCACAAGCCTGCCACGATGGCTGCTGCTCCTTGTAGCCCACC

CATGAGAAGCAAGAGACCTTAAAGGCTTCCTATCCCACCAATTACAGGG

AAAAAACGTGTGATGATCCTGAAGCTTACTATGCAGCCTACAAACAGCC

TTAGTAATTAAAACATTTTATACCAATAAAATTTTCAAATATTACTAAC

TAATGTAGCATTAACTAACGATTGGAAACTACATTTACAACTTCAAAGC

TGTTTTATACATAGAAATCAATTACAGCTTTAATTGAAAACTGTAACCA

TTTTGATAATGCAACAATAAAGCATCTTCCAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAA

In another set of preferred embodiments of the invention, any sequence, or unique portion thereof, of the CACNA1D sequences of the I.M.A.G.E. Consortium cluster NM_000720, as well as the UniGene Homo sapiens cluster Hs.399966, may be used. Similarly, any sequence encoding all or a part of the protein encoded by any CACNA1D sequence disclosed herein may be used. The consensus sequence of the I.M.A.G.E. Consortium cluster is as follows, with the assigned coding region (ending with a termination codon) underlined and preceded by the 5′ untranslated and/or non-coding region and followed by the 3′ untranslated and/or non-coding region:

(consensus sequence for CACNA1D, identified as NM_000720 or NM_000720.1)
SEQ ID NO: 4
agaataaggg cagggaccgc ggctcctatc tcttggtgat ccccttcccc attccgcccc

cgcctcaacg cccagcacag tgccctgcac acagtagtcg ctcaataaat gttcgtggat

gatgatgatg atgatgatga aaaaaatgca gcatcaacgg cagcagcaag cggaccacgc

gaacgaggca aactatgcaa gaggcaccag acttcctctt tctggtgaag gaccaacttc

tcagccgaat agctccaagc aaactgtcct gtcttggcaa gctgcaatcg atgctgctag

acaggccaag gctgcccaaa ctatgagcac ctctgcaccc ccacctgtag gatctctctc

ccaaagaaaa cgtcagcaat acgccaagag caaaaaacag ggtaactcgt ccaacagccg

acctgcccgc gcccttttct gtttatcact caataacccc atccgaagag cctgcattag

tatagtggaa tggaaaccat ttgacatatt tatattattg gctatttttg ccaattgtgt

ggccttagct atttacatcc cattccctga agatgattct aattcaacaa atcataactt

ggaaaaagta gaatatgcct tcctgattat ttttacagtc gagacatttt tgaagattat

agcgtatgga ttattgctac atcctaatgc ttatgttagg aatggatgga atttactgga

ttttgttata gtaatagtag gattgtttag tgtaattttg gaacaattaa ccaaagaaac

agaaggcggg aaccactcaa gcggcaaatc tggaggcttt gatgtcaaag ccctccgtgc

ctttcgagtg ttgcgaccac ttcgactagt gtcaggggtg cccagtttac aagttgtcct

gaactccatt ataaaagcca tggttcccct ccttcacata gcccttttgg tattatttgt

aatcataatc tatgctatta taggattgga actttttatt ggaaaaatgc acaaaacatg

tttttttgct gactcagata tcgtagctga agaggaccca gctccatgtg cgttctcagg

gaatggacgc cagtgtactg ccaatggcac ggaatgtagg agtggctggg ttggcccgaa

cggaggcatc accaactttg ataactttgc ctttgccatg cttactgtgt ttcagtgcat

caccatggag ggctggacag acgtgctcta ctgggtaaat gatgcgatag gatgggaatg

gccatgggtg tattttgtta gtctgatcat ccttggctca tttttcgtcc ttaacctggt

tcttggtgtc cttagtggag aattctcaaa ggaaagagag aaggcaaaag cacggggaga

tttccagaag ctccgggaga agcagcagct ggaggaggat ctaaagggct acttggattg

gatcacccaa gctgaggaca tcgatccgga gaatgaggaa gaaggaggag aggaaggcaa

acgaaatact agcatgccca ccagcgagac tgagtctgtg aacacagaga acgtcagcgg

tgaaggcgag aaccgaggct gctgtggaag tctctggtgc tggtggagac ggagaggcgc

ggccaaggcg gggccctctg ggtgtcggcg gtggggtcaa gccatctcaa aatccaaact

cagccgacgc tggcgtcgct ggaaccgatt caatcgcaga agatgtaggg ccgccgtgaa

gtctgtcacg ttttactggc tggttatcgt cctggtgttt ctgaacacct taaccatttc

ctctgagcac tacaatcagc cagattggtt gacacagatt caagatattg ccaacaaagt

cctcttggct ctgttcacct gcgagatgct ggtaaaaatg tacagcttgg gcctccaagc

atatttcgtc tctcttttca accggtttga ttgcttcgtg gtgtgtggtg gaatcactga

gacgatcctg gtggaactgg aaatcatgtc tcccctgggg atctctgtgt ttcggtgtgt

gcgcctctta agaatcttca aagtgaccag gcactggact tccctgagca acttagtggc

atccttatta aactccatga agtccatcgc ttcgctgttg cttctgcttt ttctcttcat

tatcatcttt tccttgcttg ggatgcagct gtttggcggc aagtttaatt ttgatgaaac

gcaaaccaag cggagcacct ttgacaattt ccctcaagca cttctcacag tgttccagat

cctgacaggc gaagactgga atgctgtgat gtacgatggc atcatggctt acgggggccc

atcctcttca ggaatgatcg tctgcatcta cttcatcatc ctcttcattt gtggtaacta

tattctactg aatgtcttct tggccatcgc tgtagacaat ttggctgatg ctgaaagtct

gaacactgct cagaaagaag aagcggaaga aaaggagagg aaaaagattg ccagaaaaga

gagcctagaa aataaaaaga acaacaaacc agaagtcaac cagatagcca acagtgacaa

caaggttaca attgatgact atagagaaga ggatgaagac aaggacccct atccgccttg

cgatgtgcca gtaggggaag aggaagagga agaggaggag gatgaacctg aggttcctgc

cggaccccgt cctcgaagga tctcggagtt gaacatgaag gaaaaaattg cccccatccc

tgaagggagc gctttcttca ttcttagcaa gaccaacccg atccgcgtag gctgccacaa

gctcatcaac caccacatct tcaccaacct catccttgtc ttcatcatgc tgagcagcgc

tgccctggcc gcagaggacc ccatccgcag ccactccttc cggaacacga tactgggtta

ctttgactat gccttcacag ccatctttac tgttgagatc ctgttgaaga tgacaacttt

tggagctttc ctccacaaag gggccttctg caggaactac ttcaatttgc tggatatgct

ggtggttggg gtgtctctgg tgtcatttgg gattcaatcc agtgccatct ccgttgtgaa

gattctgagg gtcttaaggg tcctgcgtcc cctcagggcc atcaacagag caaaaggact

taagcacgtg gtccagtgcg tcttcgtggc catccggacc atcggcaaca tcatgatcgt

cactaccctc ctgcagttca tgtttgcctg tatcggggtc cagttgttca aggggaagtt

ctatcgctgt acggatgaag ccaaaagtaa ccctgaagaa tgcaggggac ttttcatcct

ctacaaggat ggggatgttg acagtcctgt ggtccgtgaa cggatctggc aaaacagtga

tttcaacttc gacaacgtcc tctctgctat gatggcgctc ttcacagtct ccacgtttga

gggctggcct gcgttgctgt ataaagccat cgactcgaat ggagagaaca tcggcccaat

ctacaaccac cgcgtggaga tctccatctt cttcatcatc tacatcatca ttgtagcttt

cttcatgatg aacatctttg tgggctttgt catcgttaca tttcaggaac aaggagaaaa

agagtataag aactgtgagc tggacaaaaa tcagcgtcag tgtgttgaat acgccttgaa

agcacgtccc ttgcggagat acatccccaa aaacccctac cagtacaagt tctggtacgt

ggtgaactct tcgcctttcg aatacatgat gtttgtcctc atcatgctca acacactctg

cttggccatg cagcactacg agcagtccaa gatgttcaat gatgccatgg acattctgaa

catggtcttc accggggtgt tcaccgtcga gatggttttg aaagtcatcg catttaagcc

taaggggtat tttagtgacg cctggaacac gtttgactcc ctcatcgtaa tcggcagcat

tatagacgtg gccctcagcg aagcggaccc aactgaaagt gaaaatgtcc ctgtcccaac

tgctacacct gggaactctg aagagagcaa tagaatctcc atcacctttt tccgtctttt

ccgagtgatg cgattggtga agcttctcag caggggggaa ggcatccgga cattgctgtg

gacttttatt aagtcctttc aggcgctccc gtatgtggcc ctcctcatag ccatgctgtt

cttcatctat gcggtcattg gcatgcagat gtttgggaaa gttgccatga gagataacaa

ccagatcaat aggaacaata acttccagac gtttccccag gcggtgctgc tgctcttcag

gtgtgcaaca ggtgaggcct ggcaggagat catgctggcc tgtctcccag ggaagctctg

tgaccctgag tcagattaca accccgggga ggagtataca tgtgggagca actttgccat

tgtctatttc atcagttttt acatgctctg tgcatttctg atcatcaatc tgtttgtggc

tgtcatcatg gataatttcg actatctgac ccgggactgg tctattttgg ggcctcacca

tttagatgaa ttcaaaagaa tatggtcaga atatgaccct gaggcaaagg gaaggataaa

acaccttgat gtggtcactc tgcttcgacg catccagcct cccctggggt ttgggaagtt

atgtccacac agggtagcgt gcaagagatt agttgccatg aacatgcctc tcaacagtga

cgggacagtc atgtttaatg caaccctgtt tgctttggtt cgaacggctc ttaagatcaa

gaccgaaggg aacctggagc aagctaatga agaacttcgg gctgtgataa agaaaatttg

gaagaaaacc agcatgaaat tacttgacca agttgtccct ccagctggtg atgatgaggt

aaccgtgggg aagttctatg ccactttcct gatacaggac tactttagga aattcaagaa

acggaaagaa caaggactgg tgggaaagta ccctgcgaag aacaccacaa ttgccctaca

ggcgggatta aggacactgc atgacattgg gccagaaatc cggcgtgcta tatcgtgtga

tttgcaagat gacgagcctg aggaaacaaa acgagaagaa gaagatgatg tgttcaaaag

aaatggtgcc ctgcttggaa accatgtcaa tcatgttaat agtgatagga gagattccct

tcagcagacc aataccaccc accgtcccct gcatgtccaa aggccttcaa ttccacctgc

aagtgatact gagaaaccgc tgtttcctcc agcaggaaat tcggtgtgtc ataaccatca

taaccataat tccataggaa agcaagttcc cacctcaaca aatgccaatc tcaataatgc

caatatgtcc aaagctgccc atggaaagcg gcccagcatt gggaaccttg agcatgtgtc

tgaaaatggg catcattctt cccacaagca tgaccgggag cctcagagaa ggtccagtgt

gaaaagaacc cgctattatg aaacttacat taggtccgac tcaggagatg aacagctccc

aactatttgc cgggaagacc cagagataca tggctatttc agggaccccc actgcttggg

ggagcaggag tatttcagta gtgaggaatg ctacgaggat gacagctcgc ccacctggag

caggcaaaac tatggctact acagcagata cccaggcaga aacatcgact ctgagaggcc

ccgaggctac catcatcccc aaggattctt ggaggacgat gactcgcccg tttgctatga

ttcacggaga tctccaagga gacgcctact acctcccacc ccagcatccc accggagatc

ctccttcaac tttgagtgcc tgcgccggca gagcagccag gaagaggtcc cgtcgtctcc

catcttcccc catcgcacgg ccctgcctct gcatctaatg cagcaacaga tcatggcagt

tgccggccta gattcaagta aagcccagaa gtactcaccg agtcactcga cccggtcgtg

ggccacccct ccagcaaccc ctccctaccg ggactggaca ccgtgctaca cccccctgat

ccaagtggag cagtcagagg ccctggacca ggtgaacggc agcctgccgt ccctgcaccg

cagctcctgg tacacagacg agcccgacat ctcctaccgg actttcacac cagccagcct

gactgtcccc agcagcttcc ggaacaaaaa cagcgacaag cagaggagtg cggacagctt

ggtggaggca gtcctgatat ccgaaggctt gggacgctat gcaagggacc caaaatttgt

gtcagcaaca aaacacgaaa tcgctgatgc ctgtgacctc accatcgacg agatggagag

tgcagccagc accctgctta atgggaacgt gcgtccccga gccaacgggg atgtgggccc

cctctcacac cggcaggact atgagctaca ggactttggt cctggctaca gcgacgaaga

gccagaccct gggagggatg aggaggacct ggcggatgaa atgatatgca tcaccacctt

gtagccccca gcgaggggca gactggctct ggcctcaggt ggggcgcagg agagccaggg

gaaaagtgcc tcatagttag gaaagtttag gcactagttg ggagtaatat tcaattaatt

agacttttgt ataagagatg tcatgcctca agaaagccat aaacctggta ggaacaggtc

ccaagcggtt gagcctggca gagtaccatg cgctcggccc cagctgcagg aaacagcagg

ccccgccctc tcacagagga tgggtgagga ggccagacct gccctgcccc attgtccaga

tgggcactgc tgtggagtct gcttctccca tgtaccaggg caccaggccc acccaactga

aggcatggcg gcggggtgca ggggaaagtt aaaggtgatg acgatcatca cacctcgtgt

cgttacctca gccatcggtc tagcatatca gtcactgggc ccaacatatc catttttaaa

ccctttcccc caaatacact gcgtcctggt tcctgtttag ctgttctgaa ata

I.M.A.G.E. Consortium Clone ID numbers and the corresponding GenBank accession numbers of sequences identified as belonging to the I.M.A.G.E. Consortium and UniGene clusters, are listed below. Also included are sequences that are not identified as having a Clone ID number but still identified as being those of CACNA1D. The sequences include those of the “sense” and complementary strands sequences corresponding to CACNA1D. The sequence of each GenBank accession number is presented in the attached Appendix.


Clone ID numbers	GenBank accession numbers

5676430	BM128550
5197948	BI755471
6027638	BQ549084, BQ549571
2338956	AI693324
36581	R25307, R46658
49630	H29256, H29339
4798765	BG716371
2187310	AI537488
838231	AA458692
2111614	AI393327
2183482	AI520947
1851007	AI248998
1675503	AI075844
2434923	AI869807
2434924	AI869800
1845827	AI243110
2511756	AI955764
628568	AA192669, AA192157
2019331	AI361691
2337381	AI914244
2503579	AW008769
2503626	AW008794
1160989	AA877582
11653475	AI051972
1627755	AI017959
287750	N79331, N62240
1867677	AI240933
1618303	AI015031
1881344	AI290994
1408031	AA861160
1557035	AA915941
956303	AA493341
2148234	AI467998
1499899	AA885585
1647592	AI033648
2341185	AI697633
981603	AA523647
6281678	BQ710377
6278348	BQ706920
5876024	BQ016847
6608849	CA943595
5440464	BM008196
5209489	BI769856
5183025	BI758971
880540	AA468565
757337	AA437099
6608849	CA867864
461797	AA682690
434787	AA701888
6151588	BU182632
6295618	BQ898429
6300779	BQ711800
434811	AA703120
1568025	AA978315
3220210	BE550599
3214121	BE502741
13009312	AW872382
2733394	AW444663
2872156	AW341279
30514550	CF456750
2718456	AW139850
2543682	AW029633
2492730	AI963788
2545866	AI951788
2272081	AI680744
2152336	AI601252
2146429	AI459166
1274498	AA885750
2272081	BX092736
287750	BX114568
3233645	BE672659
289209	N78509, N73668
277086	N46744, N39597
3272340	BF439267
3273859	BF436153
3568401	BF110611
None (mRNA	M76558, AF088004, M83566
sequences)
None	CB410657, BQ372430, BQ366601, BQ324528,
	BQ318830, AL708030, BM509161, N85902,
	BQ774355, CA774243, CA436347, CA389011,
	BU679327, BU608029, BU073743, BE175413,
	AW969248, AI908115, BF754485, BI015409,
	BG202552, BF883669, BF817590, BF807128,
	BF806160, BF805244, BF805235, BF805080,
	T27949, BE836638, BE770685, BE769065,

In one preferred embodiment, any sequence, or unique portion thereof, of the following CACNA1D sequence, identified by AF088004 or AF088004.1, may be used in the practice of the invention.

SEQ ID NO: 5 (sequence for CACNA1D):

TTTTTTTTTTTTTTTTTTTTTCTTACAAAGAAAAATTTAATATTCGATG

AGAGGTTGAACCAGGCTTAAAGCAGACATACTAGGAAATGGTGCAGCCT

GTAAGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAGATCATCGCCTC

TATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGC

CACAAGACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACAGT

GGTGTAGCCCTTTAGGAGAAATGGCGCTCCCTGCGGCTGGTATTAGGTT

ACCATTGGCACCGAAGGAACCAGGAGGATAAGAATATCCATAATTTCAG

AGCTGCCCTGGCACAGTACCTGCCCCGTCGGAGGCTCTCACTGGCAAAT

GACAGCTCTGTGCAAGGAGCACTCCCAAGTATAAAAATTATTACACAGT

TTTATTCTGAAGAACATTTTGCATTTTAATAAAAAAGGATTTATGTCAG

GAAAGAGTCATTTACAAACCTTGAAGTGTTTTTGCCTGGATCAGAGTAA

GAATGTCTTAAGAAGAGGTTTGTAAGGTCTTCATAACAAAGTGGTGTTT

GTTATTTACAAAAAAAAAAAAAAAAAAAATTAACAGGTTGTCTGTATAC

TATTAAAAATTTTGGACCAAAAAAAAAAAAAAAAAAAA

In another set of preferred embodiments of the invention, any sequence, or unique portion thereof, of the HOXB13 sequences of the I.M.A.G.E. Consortium cluster NM_006361, as well as the UniGene Homo sapiens cluster Hs.66731, may be used. Similarly, any sequence encoding all or a part of the protein encoded by any HOXB13 sequence disclosed herein may be used. The consensus sequence of the I.M.A.G.E. Consortium cluster is as follows, with the assigned coding region (ending with a termination codon) underlined and preceded by the 5′ untranslated and/or non-coding region and followed by the 3′ untranslated and/or non-coding region:

(consensus sequence for HOXB13, identified as NM_006361 or NM_006361.2)
SEQ ID NO: 6
cgaatgcagg cgacttgcga gctgggagcg atttaaaacg ctttggattc ccccggcctg

ggtggggaga gcgagctggg tgccccctag attccccgcc cccgcacctc atgagccgac

cctcggctcc atggagcccg gcaattatgc caccttggat ggagccaagg atatcgaagg

cttgctggga gcgggagggg ggcggaatct ggtcgcccac tcccctctga ccagccaccc

agcggcgcct acgctgatgc ctgctgtcaa ctatgccccc ttggatctgc caggctcggc

ggagccgcca aagcaatgcc acccatgccc tggggtgccc caggggacgt ccccagctcc

cgtgccttat ggttactttg gaggcgggta ctactcctgc cgagtgtccc ggagctcgct

gaaaccctgt gcccaggcag ccaccctggc cgcgtacccc gcggagactc ccacggccgg

ggaagagtac cccagtcgcc ccactgagtt tgccttctat ccgggatatc cgggaaccta

ccacgctatg gccagttacc tggacgtgtc tgtggtgcag actctgggtg ctcctggaga

accgcgacat gactccctgt tgcctgtgga cagttaccag tcttgggctc tcgctggtgg

ctggaacagc cagatgtgtt gccagggaga acagaaccca ccaggtccct tttggaaggc

agcatttgca gactccagcg ggcagcaccc tcctgacgcc tgcgcctttc gtcgcggccg

caagaaacgc attccgtaca gcaaggggca gttgcgggag ctggagcggg agtatgcggc

taacaagttc atcaccaagg acaagaggcg caagatctcg gcagccacca gcctctcgga

gcgccagatt accatctggt ttcagaaccg ccgggtcaaa gagaagaagg ttctcgccaa

ggtgaagaac agcgctaccc cttaagagat ctccttgcct gggtgggagg agcgaaagtg

ggggtgtcct ggggagacca gaaacctgcc aagcccaggc tggggccaag gactctgctg

agaggcccct agagacaaca cccttcccag gccactggct gctggactgt tcctcaggag

cggcctgggt acccagtatg tgcagggaga cggaacccca tgtgacaggc ccactccacc

agggttccca aagaacctgg cccagtcata atcattcatc ctcacagtgg caataatcac

gataaccagt

I.M.A.G.E. Consortium Clone ID numbers and the corresponding GenBank accession numbers of sequences identified as belonging to the I.M.A.G.E. Consortium and UniGene clusters, are listed below. Also included are sequences that are not identified as having a Clone ID number but still identified as being those of HOXB13. The sequences include those of the “sense” and complementary strands sequences corresponding to HOXB13. The sequence of each GenBank accession number is presented in the attached Appendix.


Clone ID numbers	GenBank accession numbers

4250486	BF676461, BC007092
5518335	BM462617
4874541	BG752489
4806039	BG778198
3272315	CB050884, CB050885
4356740	BF965191
6668163	BU930208
1218366	AA807966
2437746	AI884491
1187697	AA652388
3647557	BF446158
1207949	AA657924
1047774	AA644637
3649397	BF222357
971664	AA527613
996191	AA533227
813481	AA456069, AA455572, BX117624
6256333	BQ673782
2408470	AI814453
2114743	AI417272
998548	AA535663
2116027	AI400493
3040843	AW779219
1101311	AA594847
1752062	AI150430
898712	AA494387
1218874	AA662643
2460189	AI935940
986283	AA532530
1435135	AA857572
1871750	AI261980
3915135	BE888751
2069668	AI378797
667188	AA234220, AA236353
1101561	AA588193
1170268	AI821103, AI821851, AA635855
2095067	AI420753
4432770	BG180547
783296	AA468306, AA468232
3271646	CB050115, CB050116
1219276	AA661819
30570598	CF146837
30570517	CF146763
30568921	CF144902
3099071	CF141511
3096992	CF139563
3096870	CF139372
3096623	CF139319
3096798	CF139275
30572408	CF122893
2490082	AI972423
2251055	AI918975
2419308	AI826991
2249105	AI686312
2243362	AI655923
30570697	CF146922
3255712	BF476369
3478356	BF057410
3287977	BE645544
3287746	BE645408
3621499	BE388501
30571128	CF147366
30570954	CF147143
None (mRNA	BT007410, BC007092, U57052, U81599
sequences)
None	CB120119, CB125764, AU098628, CB126130,
	BI023924, BM767063, BM794275, BQ363211,
	BM932052, AA357646, AW609525, CB126919,
	AW609336, AW609244, BF855145, AU126914,
	CB126449, AW582404, BX641644

In one preferred embodiment, any sequence, or unique portion thereof, of the following HOXB13 sequence, identified by BC007092 or BC007092.1, may be used in the practice of the invention.

SEQ ID NO: 7 (sequence for HOXB13):

GGATTCCCCCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATTC

CCCGCCCCCGCACCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGCAA

TTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCTTGCTGGGAGCGG

GAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGCG

GCGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGG

CTCGGCGGAGCCGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGG

GGACGTCCCCAGCTCCCGTGCCTTATGGTTACTTTGGAGGCGGGTACTAC

TCCTGCCGAGTGTCCCGGAGCTCGCTGAAACCCTGTGCCCAGGCAGCCAC

CCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAAGAGTACCCCA

GCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACCAG

CCTATGGCCAGTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCC

TGGAGAACCGCGACATGACTCCCTGTTGCCTGTGGACAGTTACCAGTCTT

GGGCTCTCGCTGGTGGCTGGAACAGCCAGATGTGTTGCCAGGGAGAACAG

AACCCACCAGGTCCCTTTTGGAAGGCAGCATTTGCAGACTCCAGCGGGCA

GCACCCTCCTGACGCCTGCGCCTTTCGTCGCGGCCGCAAGAAACGCATTC

CGTACAGCAAGGGGCAGTTGCGGGAGCTGGAGCGGGAGTATGCGGCTAAC

AAGTTCATCACCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGCCT

CTCGGAGCGCCAGATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAGA

AGAAGGTTCTCGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCC

TTGCCTGGGTGGGAGGAGCGAAAGTGGGGGTGTCCTGGGGAGACCAGGAA

CCTGCCAAGCCCAGGCTGGGGCCAAGGACTCTGCTGAGAGGCCCCTAGAG

ACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTCCTCAGGAGCGGC

CTGGGTACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCACT

CCACCAGGGTTCCCAAAGAACCTGGCCCAGTCATAATCATTCATCCTGAC

AGTGGCAATAATCACGATAACCAGTACTAGCTGCCATGATCGTTAGCCTC

ATATTTTCTATCTAGAGCTCTGTAGAGCACTTTAGAAACCGCTTTCATGA

ATTGAGCTAATTATGAATAAATTTGGAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAA

Sequences identified by SEQ ID NO. are provided using conventional representations of a DNA strand starting from the 5′ phosphate linked end to the 3′ hydroxyl linked end. The assignment of coding regions is generally by comparison to available consensus sequence(s) and therefore may contain inconsistencies relative to other sequences assigned to the same cluster. These have no effect on the practice of the invention because the invention can be practiced by use of shorter segments (or combinations thereof) of sequences unique to each of the three sets described above and not affected by inconsistencies. As non-limiting examples, a segment of IL17BR, CACNA1D, or HOXB13 nucleic acid sequence composed of a 3′ untranslated region sequence and/or a sequence from the 3′ end of the coding region may be used as a probe for the detection of IL17BR, CACNA1D, or HOXB13 expression, respectively, without being affected by the presence of any inconsistency in the coding regions due to differences between sequences. Similarly, the use of an antibody which specifically recognizes IL17BR, CACNA1D, or HOXB13 protein to detect its expression would not be affected by the presence of any inconsistency in the representation of the coding regions provided above.
As will be appreciated by those skilled in the art, some of the above sequences include 3′ poly A (or poly T on the complementary strand) stretches that do not contribute to the uniqueness of the disclosed sequences. The invention may thus be practiced with sequences lacking the 3′ poly A (or poly T) stretches. The uniqueness of the disclosed sequences refers to the portions or entireties of the sequences which are found only in IL17BR, CACNA1D, or HOXB13 nucleic acids, including unique sequences found at the 3′ untranslated portion of the genes. Preferred unique sequences for the practice of the invention are those which contribute to the consensus sequences for each of the three sets such that the unique sequences will be useful in detecting expression in a variety of individuals rather than being specific for a polymorphism present in some individuals. Alternatively, sequences unique to an individual or a subpopulation may be used. The preferred unique sequences are preferably of the lengths of polynucleotides of the invention as discussed herein.
To determine the (increased or decreased) expression levels of the above described sequences in the practice of the present invention, any method known in the art may be utilized. In one preferred embodiment of the invention, expression based on detection of RNA which hybridizes to polynucleotides containing the above described sequences is used. This is readily performed by any RNA detection or amplification+detection method known or recognized as equivalent in the art such as, but not limited to, reverse transcription-PCR (optionally real-time PCR), the methods disclosed in U.S. patent application Ser. No. 10/062,857 entitled “Nucleic Acid Amplification” filed on Oct. 25, 2001 as well as U.S. Provisional Patent Applications 60/298,847 (filed Jun. 15, 2001) and 60/257,801 (filed Dec. 22, 2000), the methods disclosed in U.S. Pat. No. 6,291,170, and quantitative PCR. Methods to identify increased RNA stability (resulting in an observation of increased expression) or decreased RNA stability (resulting in an observation of decreased expression) may also be used. These methods include the detection of sequences that increase or decrease the stability of mRNAs containing the IL17BR, CACNA1D, or HOXB13 sequences disclosed herein. These methods also include the detection of increased mRNA degradation.
In particularly preferred embodiments of the invention, polynucleotides having sequences present in the 3′ untranslated and/or non-coding regions of the above disclosed sequences are used to detect expression or non-expression of IL17BR, CACNA1D, or HOXB13 sequences in breast cells in the practice of the invention. Such polynucleotides may optionally contain sequences found in the 3′ portions of the coding regions of the above disclosed sequences. Polynucleotides containing a combination of sequences from the coding and 3′ non-coding regions preferably have the sequences arranged contiguously, with no intervening heterologous sequence(s).
Alternatively, the invention may be practiced with polynucleotides having sequences present in the 5′ untranslated and/or non-coding regions of IL17BR, CACNA1D, or HOXB13 sequences in breast cells to detect their levels of expression. Such polynucleotides may optionally contain sequences found in the 5′ portions of the coding regions. Polynucleotides containing a combination of sequences from the coding and 5′ non-coding regions preferably have the sequences arranged contiguously, with no intervening heterologous sequence(s). The invention may also be practiced with sequences present in the coding regions of IL17BR, CACNA1D, or HOXB13.
Preferred polynucleotides contain sequences from 3′ or 5′ untranslated and/or non-coding regions of at least about 16, at least about 18, at least about 20, at least about 22, at least about 24, at least about 26, at least about 28, at least about 30, at least about 32, at least about 34, at least about 36, at least about 38, at least about 40, at least about 42, at least about 44, or at least about 46 consecutive nucleotides. The term “about” as used in the previous sentence refers to an increase or decrease of 1 from the stated numerical value. Even more preferred are polynucleotides containing sequences of at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides. The term “about” as used in the preceding sentence refers to an increase or decrease of 10% from the stated numerical value.
Sequences from the 3′ or 5′ end of the above described coding regions as found in polynucleotides of the invention are of the same lengths as those described above, except that they would naturally be limited by the length of the coding region. The 3′ end of a coding region may include sequences up to the 3′ half of the coding region. Conversely, the 5′ end of a coding region may include sequences up the 5′ half of the coding region. Of course the above described sequences, or the coding regions and polynucleotides containing portions thereof, may be used in their entireties.
Polynucleotides combining the sequences from a 3′ untranslated and/or non-coding region and the associated 3′ end of the coding region are preferably at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides. Preferably, the polynucleotides used are from the 3′ end of the gene, such as within about 350, about 300, about 250, about 200, about 150, about 100, or about 50 nucleotides from the polyadenylation signal or polyadenylation site of a gene or expressed sequence. Polynucleotides containing mutations relative to the sequences of the disclosed genes may also be used so long as the presence of the mutations still allows hybridization to produce a detectable signal.
In another embodiment of the invention, polynucleotides containing deletions of nucleotides from the 5′ and/or 3′ end of the above disclosed sequences may be used. The deletions are preferably of 1-5, 5-10, 10-15, 15-20, 20-25, 25-30, 30-35, 35-40, 40-45, 45-50, 50-60, 60-70, 70-80, 80-90, 90-100, 100-125, 125-150, 150-175, or 175-200 nucleotides from the 5′ and/or 3′ end, although the extent of the deletions would naturally be limited by the length of the disclosed sequences and the need to be able to use the polynucleotides for the detection of expression levels.
Other polynucleotides of the invention from the 3′ end of the above disclosed sequences include those of primers and optional probes for quantitative PCR. Preferably, the primers and probes are those which amplify a region less than about 350, less than about 300, less than about 250, less than about 200, less than about 150, less than about 100, or less than about 50 nucleotides from the from the polyadenylation signal or polyadenylation site of a gene or expressed sequence.
In yet another embodiment of the invention, polynucleotides containing portions of the above disclosed sequences including the 3′ end may be used in the practice of the invention. Such polynucleotides would contain at least or about 50, at least or about 100, at least about or 150, at least or about 200, at least or about 250, at least or about 300, at least or about 350, or at least or about 400 consecutive nucleotides from the 3′ end of the disclosed sequences.
The invention thus also includes polynucleotides used to detect IL17BR, CACNA1D, or HOXB13 expression in breast cells. The polynucleotides may comprise a shorter polynucleotide consisting of sequences found in the above provided SEQ ID NOS in combination with heterologous sequences not naturally found in combination with IL17BR, CACNA1D, or HOXB13 sequences.
As non-limiting examples, a polynucleotide comprising one of the following sequences may be used in the practice of the invention.

SEQ ID NO: 8:

CAATTACAGGGAAAAAACGTGTGATGATCCTGAAGCTTACTATGCAGCCT

ACAAACAGCC

SEQ ID NO: 9:

GCTCTCACTGGCAAATGACAGCTCTGTGCAAGGAGCACTCCCAAGTATAA

AAATTATTAC

SEQ ID NO: 10:

GATCGTTAGCCTCATATTTTCTATCTAGAGCTCTGTAGAGCACTTTAGAA

ACCGCTTTCA

Stated differently, the invention may be practiced with a polynucleotide consisting of the sequence of SEQ ID NOS:8, 9 or 10 in combination with one or more heterologous sequences that are not normally found with SEQ ID NOS:8, 9 or 10. Alternatively, the invention may also be practiced with a polynucleotide consisting of the sequence of SEQ ID NOS:8, 9 or 10 in combination with one or more naturally occurring sequences that are normally found with SEQ ID NOS:8, 9 or 10.
Polynucleotides with sequences comprising SEQ ID NOS:8 or 9, either naturally occurring or synthetic, may be used to detect nucleic acids which are over expressed in breast cancer cells that are responsive, and those which are not over expressed in breast cancer cells that are non-responsive, to treatment with TAM or another “antiestrogen” agent against breast cancer. Polynucleotides with sequences comprising SEQ ID NO:10, either naturally occurring or synthetic, may be used to detect nucleic acids which are under expressed in breast cancer cells that are responsive, and those which are not under expressed in breast cancer cells that are non-responsive, to treatment with TAM or another “antiestrogen” agent against breast cancer.
Additional sequences that may be used in polynucleotides as described above for SEQ ID NOS:8 and 9 are the following, wherein SEQ ID NOs:33 is complementary to a portion of IL17BR sequences disclosed herein:

SEQ ID NO: 11:

TGCCTAATTTCACTCTCAGAGTGAGGCAGGTAACTGGGGCTCCACTGGG

TCACTCTGAGA

SEQ ID NO: 12:

TTGGAAGCAGAGTCCCTCTAAAGGTAACTCTTGTGGTCACTCAATATTG

TATTGGCATTT

SEQ ID NO: 13:

ACGTTAGACTTTTGCTGGCATTCAAGTCATGGCTAGTCTGTGTATTTAA

TAAATGTGTGT

SEQ ID NO: 14:

CTGGTCAGCCACTCTGACTTTTCTACCACATTAAATTCTCCATTACATC

TCACTATTGGT

SEQ ID NO: 15:

TACAACTTCTGAATGCTGCACATTCTTCCAAAATGATCCTTAGCACAAT

CTATTGTATGA

SEQ ID NO: 16:

GGGATGGCCTTTAGGCCACAGTAGTGTCTGTGTTAAGTTCACTAAATGT

GTATTTAATGA

SEQ rD NO: 17:

CTCAAAGTGCTAAAGCTATGGTTGACTGCTCTGGTGTTTTTATATTCAT

TCGTGCTTTAG

SEQ ID NO: 32:

CTGAAGCTTACTATGCAGCCTACAA

SEQ ID NO: 33:

TCCAATCGTTAGTTAATGCTACATTAGTT

SEQ ID NO: 34:

CAGCCTTAGTAATTAAAAC

Additional sequences that may be used in polynucleotides as described above for SEQ ID NO:10 are the following, wherein SEQ ID NOs:36 is complementary to a portion of IL17BR sequences disclosed herein:

SEQ ID NO: 18:

CTATGGGGATGGTCCACTGTCACTGTTTCTCTGCTGTTGCAAATACATG

GATAACACATT

SEQ ED NO: 19:

ACTGGAAAAGCAGATGGTCTGACTGTGCTATGGCCTCATCATCAAGACT

TTCAATCCTAT

SEQ ID NO :20:

ACGCCAAGCTCTTCAGTGAAGACACGATGTTATTAAAAGCCTGTTTTAG

GGACTGCAAAA

SEQ ED NO: 21:

TTTTTGTAAAATCTTTAACCTTCCCTTTGTTCTTCATGTACACGCTGAA

CTGCAATTCTT

SEQ ID NO: 22:

AACCTGGGGCATTTAGGGCAGAGGACAAAAGGATGTCAGCAATTGCTTG

GGCTGCTTGGC

SEQ ID NO: 23:

CTGGAACCTCTGGACTCCCCATGCTCTAACTCCCACACTCTGCTATCAG

AAACTTAAACT

SEQ ID NO: 24:

AACCCCAGAACCATCTAAGACATGGGATTCAGTGATCATGTGGTTCTCC

TTTTAACTTAC

SEQ ID NO: 25:

GGCCATGTGCCATGGTATTTGGGTCCTGGGAGGGTGGGTGAAATAAAGG

CATACTGTCTT

SEQ ID NO: 26:

GTGTAGGCAGTCATGGCACCAAAGCCACCAGACTGACAAATGTGTATCA

GATGCTTTTGT

SEQ ID NO: 27:

GAAAACCTCTTCAAAAGACAAAAAGCTGGCACTGCATTCTCTCTCTGTA

GCAGGACAGAA

SEQ ID NO: 28:

CACATCTTTAGGGTCAGTGAACAATGGGGCACATTTGGCACTAGCTTGA

GCCCAACTCTG

SEQ ID NO: 29:

GCCTTAATTTCCTCATCTGAAAACTGGAAGGCCTGACTTGACTTGTTGA

GCTTAAGATCC

SEQ ID NO: 30:

CTTCAGGGGAGGATCAAGCTTTGAACCAAAGCCAATCACTGGCTTGATT

TGTGTTTTTTA

SEQ ID NO: 31:

ACAAGTTTTCACTGAATGAGCATGGCAGTGCCACTCAAGAAAATGAATC

TCCAAAGTATC

SEQ ID NO: 35:

GCCATGATCGTTAGCCTCATATT

SEQ ID NO: 36:

CAATTCATGAAAGCGGTTTCTAAAG

SEQ ID NO: 37:

TCTATCTAGAGCTCTGTAGAGC

Additionally, polynucleotides containing other sequences, particularly unique sequences, present in naturally occurring nucleic acid molecules comprising SEQ ID NOS:8-37 may be used in the practice of the invention.
Other polynucleotides for use in the practice of the invention include those that have sufficient homology to those described above to detect expression by use of hybridization techniques. Such polynucleotides preferably have about or 95%, about or 96%, about or 97%, about or 98%, or about or 99% identity with IL17BR, CACNA1D, or HOXB13 sequences as described herein. Identity is determined using the BLAST algorithm, as described above. The other polynucleotides for use in the practice of the invention may also be described on the basis of the ability to hybridize to polynucleotides of the invention under stringent conditions of about 30% v/v to about 50% formamide and from about 0.01M to about 0.15M salt for hybridization and from about 0.01M to about 0.15M salt for wash conditions at about 55 to about 65° C. or higher, or conditions equivalent thereto.
In a further embodiment of the invention, a population of single stranded nucleic acid molecules comprising one or both strands of a human IL17BR or CACNA1D sequence is provided as a probe such that at least a portion of said population may be hybridized to one or both strands of a nucleic acid molecule quantitatively amplified from RNA of a breast cancer cell. The population may be only the antisense strand of a human IL17BR or CACNA1D sequence such that a sense strand of a molecule from, or amplified from, a breast cancer cell may be hybridized to a portion of said population. The population preferably comprises a sufficiently excess amount of said one or both strands of a human IL17BR or CACNA1D sequence in comparison to the amount of expressed (or amplified) nucleic acid molecules containing a complementary IL17BR or CACNA1D sequence from a normal breast cell. This condition of excess permits the increased amount of nucleic acid expression in a breast cancer cell to be readily detectable as an increase.
Alternatively, the population of single stranded molecules is equal to or in excess of all of one or both strands of the nucleic acid molecules amplified from a breast cancer cell such that the population is sufficient to hybridize to all of one or both strands. Preferred cells are those of a breast cancer patient that is ER+ or for whom treatment with tamoxifen or one or more other “antiestrogen” agent against breast cancer is contemplated. The single stranded molecules may of course be the denatured form of any IL17BR and/or CACNA1D sequence containing double stranded nucleic acid molecule or polynucleotide as described herein.
The population may also be described as being hybridized to IL17BR or CACNA1D sequence containing nucleic acid molecules at a level of at least twice as much as that by nucleic acid molecules of a normal breast cell. As in the embodiments described above, the nucleic acid molecules may be those quantitatively amplified from a breast cancer cell such that they reflect the amount of expression in said cell.
The population is preferably immobilized on a solid support, optionally in the form of a location on a microarray. A portion of the population is preferably hybridized to nucleic acid molecules quantitatively amplified from a non-normal or abnormal breast cell by RNA amplification. The amplified RNA may be that derived from a breast cancer cell, as long as the amplification used was quantitative with respect to IL17BR or CACNA1D containing sequences.
In another embodiment of the invention, expression based on detection of DNA status may be used. Detection of the HOXB13 DNA as methylated, deleted or otherwise inactivated, may be used as an indication of decreased expression as found in non-normal breast cells. This may be readily performed by PCR based methods known in the art. The status of the promoter regions of HOXB13 may also be assayed as an indication of decreased expression of HOXB13 sequences. A non-limiting example is the methylation status of sequences found in the promoter region.
Conversely, detection of the DNA of a sequence as amplified may be used for as an indication of increased expression as found in non-normal breast cells. This may be readily performed by PCR based, fluorescent in situ hybridization (FISH) and chromosome in situ hybridization (CISH) methods known in the art.
A preferred embodiment using a nucleic acid based assay to determine expression is by immobilization of one or more of the sequences identified herein on a solid support, including, but not limited to, a solid substrate as an array or to beads or bead based technology as known in the art. Alternatively, solution based expression assays known in the art may also be used. The immobilized sequence(s) may be in the form of polynucleotides as described herein such that the polynucleotide would be capable of hybridizing to a DNA or RNA corresponding to the sequence(s).
The immobilized polynucleotide(s) may be used to determine the state of nucleic acid samples prepared from sample breast cancer cell(s), optionally as part of a method to detect ER status in said cell(s). Without limiting the invention, such a cell may be from a patient suspected of being afflicted with, or at risk of developing, breast cancer. The immobilized polynucleotide(s) need only be sufficient to specifically hybridize to the corresponding nucleic acid molecules derived from the sample (and to the exclusion of detectable or significant hybridization to other nucleic acid molecules).
In yet another embodiment of the invention, a ratio of the expression levels of two of the disclosed genes may be used to predict response to treatment with TAM or another SERM. Preferably, the ratio is that of two genes with opposing patterns of expression, such as an underexpressed gene to an overexpressed gene, in correlation to the same phenotype. Non-limiting examples include the ratio of HOXB13 over IL17BR or the ratio of HOXB13 over CACNA1D. This aspect of the invention is based in part on the observation that such a ratio has a stronger correlation with TAM treatment outcome than the expression level of either gene alone. For example, the ratio of HOXB13 over IL17BR has an observed classification accuracy of 77%.
As a non-limiting example, the Ct values from Q-PCR based detection of gene expression levels may be used to derive a ratio to predict the response to treatment with one or more “antiestrogen” agent against breast cancer.

Additional Embodiments of the Invention

In embodiments where only one or a few genes are to be analyzed, the nucleic acid derived from the sample breast cancer cell(s) may be preferentially amplified by use of appropriate primers such that only the genes to be analyzed are amplified to reduce contaminating background signals from other genes expressed in the breast cell. Alternatively, and where multiple genes are to be analyzed or where very few cells (or one cell) is used, the nucleic acid from the sample may be globally amplified before hybridization to the immobilized polynucleotides. Of course RNA, or the cDNA counterpart thereof may be directly labeled and used, without amplification, by methods known in the art.
Sequence expression based on detection of a presence, increase, or decrease in protein levels or activity may also be used. Detection may be performed by any immunohistochemistry (IHC) based, bodily fluid based (where a IL17BR, CACNA1D, and/or HOXB13 polypeptide is found in a bodily fluid, such as but not limited to blood), antibody (including autoantibodies against the protein where present) based, ex foliate cell (from the cancer) based, mass spectroscopy based, and image (including used of labeled ligand where available) based method known in the art and recognized as appropriate for the detection of the protein. Antibody and image based methods are additionally useful for the localization of tumors after determination of cancer by use of cells obtained by a non-invasive procedure (such as ductal lavage or fine needle aspiration), where the source of the cancerous cells is not known. A labeled antibody or ligand may be used to localize the carcinoma(s) within a patient.
Antibodies for use in such methods of detection include polyclonal antibodies, optionally isolated from naturally occurring sources where available, and monoclonal antibodies, including those prepared by use of IL17BR, CACNA1D, and/or HOXB13 polypeptides as antigens. Such antibodies, as well as fragments thereof (including but not limited to F_abfragments) function to detect or diagnose non-normal or cancerous breast cells by virtue of their ability to specifically bind IL17BR, CACNA1D, or HOXB13 polypeptides to the exclusion of other polypeptides to produce a detectable signal. Recombinant, synthetic, and hybrid antibodies with the same ability may also be used in the practice of the invention. Antibodies may be readily generated by immunization with a IL17BR, CACNA1D, or HOXB13 polypeptide, and polyclonal sera may also be used in the practice of the invention.
Antibody based detection methods are well known in the art and include sandwich and ELISA assays as well as Western blot and flow cytometry based assays as non-limiting examples. Samples for analysis in such methods include any that contain IL17BR, CACNA1D, or HOXB13 polypeptides. Non-limiting examples include those containing breast cells and cell contents as well as bodily fluids (including blood, serum, saliva, lymphatic fluid, as well as mucosal and other cellular secretions as non-limiting examples) that contain the polypeptides.
The above assay embodiments may be used in a number of different ways to identify or detect the response to treatment with TAM or another “antiestrogen” agent against breast cancer based on gene expression in a breast cancer cell sample from a patient. In some cases, this would reflect a secondary screen for the patient, who may have already undergone mammography or physical exam as a primary screen. If positive from the primary screen, the subsequent needle biopsy, ductal lavage, fine needle aspiration, or other analogous minimally invasive method may provide the sample for use in the assay embodiments before, simultaneous with, or after assaying for ER status. The present invention is particularly useful in combination with non-invasive protocols, such as ductal lavage or fine needle aspiration, to prepare a breast cell sample.
The present invention provides a more objective set of criteria, in the form of gene expression profiles of a discrete set of genes, to discriminate (or delineate) between breast cancer outcomes. In particularly preferred embodiments of the invention, the assays are used to discriminate between good and poor outcomes after treatment with tamoxifen or another “antiestrogen” agent against breast cancer. Comparisons that discriminate between outcomes after about 10, about 20, about 30, about 40, about 50, about 60, about 70, about 80, about 90, about 100, or about 150 months may be performed.
While good and poor survival outcomes may be defined relatively in comparison to each other, a “good” outcome may be viewed as a better than 50% survival rate after about 60 months post surgical intervention to remove breast cancer tumor(s). A “good” outcome may also be a better than about 60%, about 70%, about 80% or about 90% survival rate after about 60 months post surgical intervention. A “poor” outcome may be viewed as a 50% or less survival rate after about 60 months post surgical intervention to remove breast cancer tumor(s). A “poor” outcome may also be about a 70% or less survival rate after about 40 months, or about a 80% or less survival rate after about 20 months, post surgical intervention.
In another embodiment of the invention based on the expression of a few genes, the isolation and analysis of a breast cancer cell sample may be performed as follows:

- (1) Ductal lavage or other non-invasive procedure is performed on a patient to obtain a sample.
- (2) Sample is prepared and coated onto a microscope slide. Note that ductal lavage results in clusters of cells that are cytologically examined as stated above.
- (3) Pathologist or image analysis software scans the sample for the presence of atypical cells.
- (4) If atypical cells are observed, those cells are harvested (e.g. by microdissection such as LCM).
- (5) RNA is extracted from the harvested cells.
- (6) RNA is assayed, directly or after conversion to cDNA or amplification therefrom, for the expression of IL17BR, CACNA1D, and/or HOXB13 sequences.

With use of the present invention, skilled physicians may prescribe or withhold treatment with TAM or another “antiestrogen” agent against breast cancer based on prognosis determined via practice of the instant invention.
The above discussion is also applicable where a palpable lesion is detected followed by fine needle aspiration or needle biopsy of cells from the breast. The cells are plated and reviewed by a pathologist or automated imaging system which selects cells for analysis as described above.
The present invention may also be used, however, with solid tissue biopsies, including those stored as an FFPE specimen. For example, a solid biopsy may be collected and prepared for visualization followed by determination of expression of one or more genes identified herein to determine the breast cancer outcome. As another non-limiting example, a solid biopsy may be collected and prepared for visualization followed by determination of HOXB13, IL17BR and/or CACNA1D expression. One preferred means is by use of in situ hybridization with polynucleotide or protein identifying probe(s) for assaying expression of said gene(s).
In an alternative method, the solid tissue biopsy may be used to extract molecules followed by analysis for expression of one or more gene(s). This provides the possibility of leaving out the need for visualization and collection of only cancer cells or cells suspected of being cancerous. This method may of course be modified such that only cells that have been positively selected are collected and used to extract molecules for analysis. This would require visualization and selection as a prerequisite to gene expression analysis. In the case of an FFPE sample, cells may be obtained followed by RNA extraction, amplification and detection as described herein.
In a further alternative to all of the above, the sequence(s) identified herein may be used as part of a simple PCR or array based assay simply to determine the response to treatment with TAM or another “antiestrogen” agent against breast cancer by use of a sample from a non-invasive or minimally invasive sampling procedure. The detection of sequence expression from samples may be by use of a single microarray able to assay expression of the disclosed sequences as well as other sequences, including sequences known not to vary in expression levels between normal and non-normal breast cells, for convenience and improved accuracy.
Other uses of the present invention include providing the ability to identify breast cancer cell samples as having different responses to treatment with TAM or another “antiestrogen” agent against breast cancer for further research or study. This provides an advance based on objective genetic/molecular criteria.
The genes identified herein also may be used to generate a model capable of predicting the breast cancer survival and recurrence outcomes of an ER+ breast cell sample based on the expression of the identified genes in the sample. Such a model may be generated by any of the algorithms described herein or otherwise known in the art as well as those recognized as equivalent in the art using gene(s) (and subsets thereof) disclosed herein for the identification of breast cancer outcomes. The model provides a means for comparing expression profiles of gene(s) of the subset from the sample against the profiles of reference data used to build the model. The model can compare the sample profile against each of the reference profiles or against a model defining delineations made based upon the reference profiles. Additionally, relative values from the sample profile may be used in comparison with the model or reference profiles.
In a preferred embodiment of the invention, breast cell samples identified as normal and cancerous from the same subject may be analyzed, optionally by use of a single microarray, for their expression profiles of the genes used to generate the model. This provides an advantageous means of identifying survival and recurrence outcomes based on relative differences from the expression profile of the normal sample. These differences can then be used in comparison to differences between normal and individual cancerous reference data which was also used to generate the model.
Articles of Manufacture
The materials and methods of the present invention are ideally suited for preparation of kits produced in accordance with well known procedures. The invention thus provides kits comprising agents (like the polynucleotides and/or antibodies described herein as non-limiting examples) for the detection of expression of the disclosed sequences. Such kits, optionally comprising the agent with an identifying description or label or instructions relating to their use in the methods of the present invention, are provided. Such a kit may comprise containers, each with one or more of the various reagents (typically in concentrated form) utilized in the methods, including, for example, pre-fabricated microarrays, buffers, the appropriate nucleotide triphosphates (e.g., dATP, dCTP, dGTP and dTTP; or rATP, rCTP, rGTP and UTP), reverse transcriptase, DNA polymerase, RNA polymerase, and one or more primer complexes of the present invention (e.g., appropriate length poly(T) or random primers linked to a promoter reactive with the RNA polymerase). A set of instructions will also typically be included.
The methods provided by the present invention may also be automated in whole or in part. All aspects of the present invention may also be practiced such that they consist essentially of a subset of the disclosed genes to the exclusion of material irrelevant to the identification of breast cancer survival outcomes via a cell containing sample.
Having now generally described the invention, the same will be more readily understood through reference to the following examples which are provided by way of illustration, and are not intended to be limiting of the present invention, unless specified.

EXAMPLES

Example 1

General Methods

Patient and Tumor Selection Criteria and Study Design
Patient inclusion criteria for this study were: Women diagnosed at the Massachusetts General Hospital (MGH) between 1987 and 2000 with ER positive breast cancer, treatment with standard breast surgery (modified radical mastectomy or lumpectomy) and radiation followed by five years of systemic adjuvant tamoxifen; no patient received chemotherapy prior to recurrence. Clinical and follow-up data were derived from the MGH tumor registry. There were no missing registry data and all available medical records were reviewed as a second tier of data confirmation.
All tumor specimens collected at the time of initial diagnosis were obtained from frozen and formalin fixed paraffin-embedded (FFPE) tissue repositories at the Massachusetts General Hospital. Tumor samples with greater than 20% tumor cells were selected with a median of greater than 75% for all samples. Each sample was evaluated for the following features: tumor type (ductal vs. lobular), tumor size, and Nottingham combined histological grade. Estrogen and progesterone receptor expression were determined by biochemical hormone binding analysis and/or by immunohistochemical staining as described (Long, A. A. et al. “High-specificity in-situ hybridization. Methods and application.” Diagn Mol Pathol 1, 45-57 (1992)); receptor positivity was defined as greater than 3 fmol/mg tumor tissue (Long et al.) and greater than 1% nuclear staining for the biochemical and immunohistochemical assays, respectively.
Study design is as follows: A training set of 60 frozen breast cancer specimens was selected to identify gene expression signatures predictive of outcome or response, in the setting of adjuvant tamoxifen therapy. Tumors from responders were matched to the non-responders with respect to TNM staging and tumor grade. Differential gene expression identified in the training set was validated in an independent group of 20 invasive breast tumors with formalin fixed paraffin-embedded (FFPE) tissue samples.
LCM, RNA Isolation and Amplification
With each frozen tumor sample within the 60-case cohort, RNA was isolated from both a whole tissue section of 8 μm in thickness and a highly enriched population of 4,000-5,000 malignant epithelial cells acquired by laser capture microdissection using a PixCell IIe LCM system (Arcturus, Mountain View, Calif.). From each tumor sample within the 20-case test set, RNA was isolated from four 8 μm-thick FFPE tissue sections. Isolated RNA was subjected to one round of T7 polymerase in vitro transcription using the RiboAmp™ kit (frozen samples) or another system for FFPE samples according to manufacturer's instructions (Arcturus Bioscience, Inc., Mountain View, Calif. for RiboAmp™). Labeled cRNA was generated by a second round of T7-based RNA in vitro transcription in the presence of 5-[3-Aminoallyl]uridine 5′-triphosphate (Sigma-Aldrich, St. Louis, Mo.). Universal Human Reference RNA (Stratagene, San Diego, Calif.) was amplified in the same manner. The purified aRNA was later conjugated to Cy5 (experimental samples) or Cy3 (reference sample) dye (Amersham Biosciences).
Microarray Analysis
A custom designed 22,000-gene oligonucleotide (60mer) microarray was fabricated using ink-jet in-situ synthesis technology (Agilent Technologies, Palo Alto, Calif.). Cy5-labeled sample RNA and Cy3-labeled reference RNA were co-hybridized at 65° C., 1× hybridization buffer (Agilent Technologies). Slides were washed at 37° C. with 0.1×SSC/0.005% Triton X-102. Image analysis was performed using Agilent's image analysis software. Raw Cy5/Cy3 ratios were normalized using intensity-dependent non-linear regression.
A data matrix consisting of normalized Cy5/Cy3 ratios from all samples were median centered for each gene. The variance of each gene over all samples was calculated and the top 25% high variance genes (5,475) selected for further analysis. Identification and permutation testing for significance of differential gene expression were performed using BRB ArrayTools, developed by Dr. Richard Simon and Amy Peng (see http site at linus.nci.nih.gov/BRB-ArrayTools.html). Hierarchical cluster analysis was performed with GeneMaths software (Applied-Maths, Belgium) using cosine correlation and complete linkage. All other statistical procedures (two-sample t-test, receiver operating characteristic analysis, multivariate logistic regression and survival analysis) were performed in the open source R statistical environment (see http site at www.r-project.org). Statistical test of significance of ROC curves was by the method of DeLong (“Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.” Biometrics 44, 837-45 (1988)). Disease free survival was calculated from the date of diagnosis. Events were scored as the first distant metastasis, and patients remaining disease-free at the last follow-up were censored. Survival curves were calculated by the Kaplan-Meier estimates and compared by log-rank tests.
Real-Time Quantitative PCR Analysis
Real-time PCR was performed on 59 of the 60-case training samples (one case was excluded due to insufficient materials) and the 20-case validation samples. Briefly, 2 μg of amplified RNA was converted into double stranded cDNA. For each case 12 ng of cDNA in triplicates was used for real-time PCR with an ABI 7900HT (Applied Biosystems) as described (Gelmini, S. et al. “Quantitative polymerase chain reaction-based homogeneous assay with fluorogenic probes to measure c-erbB-2 oncogene amplification.” Clin Chem 43, 752-8 (1997)). The sequences of the PCR primer pairs and fluorogenic MGB probe (5′ to 3′), respectively, that were used for each gene are as follows:

	HoxB13
	TTCATCCTGACAGTGGCAATAATC,

	CTAGATAGAAAATATGAGGCTAACGATCAT,

	VIC-CGATAACCAGTACTAGCTG;

	IL17BR
	GCATTAACTAACGATTGGAAACTACATT,

	GGAAGATGCTTTATTGTTGCATTATC,

	VIC-ACAACTTCAAAGCTGTTTTA.

Relative expression levels of HOXB13 in normal, DCIS and DC samples were calculated as follows. First, all CT values are adjusted by subtracting the highest CT (40) among all samples, then relative expression=1/2̂CT.
In Situ Hybridization
Dig-labeled RNA probes were prepared using DIG RNA labeling kit (SP6/T7) from Roche Applied Science, following the protocol provided with the kit. In situ hybridization was performed on frozen tissue sections as described (Long et al.).

TABLE 1

Patients and tumor characteristics of training set.

	Tumor
Sample ID	type	Size	Grade	Nodes	ER	PR	Age	DFS	Status

1389	D	1.7	2	0/1	Pos	Pos	80	94	0
648	D	1.1	2	0/15	Pos	ND	62	160	0
289	D	3	2	0/15	Pos	ND	75	63	1
749	D	1.8	2	2/9	Pos	Pos	61	137	0
420	D/L	2	3	ND	Pos	Pos	72	58	1
633	D	2.7	3	0/11	Pos	ND	61	20	1
662	D	1	3	6/11	Pos	Pos	79	27	1
849	D	2	1	0/26	Pos	Neg	75	23	1
356	D	1	2	2/20	Pos	ND	58	24	1
1304	D	2	3	0/14	Pos	Pos	57	20	1
1419	D	2.5	2	1/8	Pos	Pos	59	86	0
1093	D	1	3	1/14	Pos	Pos	66	85	0
1047	D/L	2.6	2	0/18	Pos	Neg	70	128	0
1037	D/L	1.5	2	0/4	Pos	Pos	85	83	0
319	D	4	2	1/13	Pos	ND	67	44	1
25	D	3.5	2	0/9	Neg	Pos	62	75	1
180	D	1.6	2	2/19	Pos	Pos	69	169	0
687	D	3.5	3	3/16	Pos	ND	73	142	0
856	D	1.6	2	0/16	Pos	Pos	73	88	0
1045	D	2.5	3	1/12	Pos	Neg	73	121	0
1205	D	2.7	2	1/19	Pos	Pos	71	88	0
1437	D	1.7	2	2/22	Pos	Pos	67	89	0
1507	D	3.7	3	0/40	Pos	Pos	70	70	0
469	D	1	1	0/19	Pos	ND	66	161	0
829	D	1.2	2	0/9	Pos	ND	69	136	0
868	D	3	3	0/13	Pos	Pos	65	130	0
1206	D	4.1	3	0/15	Pos	Neg	84	56	1
843	D	3.4	2	11/20	Pos	Neg	76	122	1
342	D	3	2	9/21	Pos	ND	62	102	1
1218	D	4.5	1	3/16	Pos	Pos	62	10	1
547	D/L	1.5	2	ND	Pos	ND	74	129	1
1125	D	2.6	2	0/18	Pos	Pos	54	123	0
1368	D	2.6	2	ND	Pos	Pos	82	63	0
605	D	2.2	2	6/18	Pos	ND	70	110	0
59	L	3	2	33/38	Pos	ND	70	21	1
68	D	3	2	0/17	Pos	ND	53	38	1
317	D	1.2	3	1/10	Pos	Pos	71	5	1
374	D	1	3	0/15	Pos	Neg	57	47	1
823	D	2	2	0/6	Pos	Pos	51	69	1
280	D	2.2	3	0/12	Pos	ND	66	44	1
651	D	4.7	3	10/13	Pos	ND	48	137	1
763	D	1.8	2	0/14	Pos	Pos	63	118	0
1085	D	4.7	2	0/8	Pos	Pos	48	101	1
1363	D	2.1	2	0/15	Pos	Pos	56	114	0
295	D	3.5	2	3/21	Pos	Pos	52	118	1
871	D	4	3	0/16	Pos	Neg	61	6	1
1343	D	2.5	3	ND	Pos	Pos	79	21	1
140	L	>2.0	2	18/28	Pos	ND	63	43	1
260	D/L	0.9	2	1/13	Pos	ND	73	42	1
297	D	0.8	2	1/16	Pos	Pos	66	169	0
1260	D	3.5	2	0/14	Pos	Pos	58	79	0
1405	D	1	3	ND	Pos	Pos	81	95	0
518	L	5.5	2	3/20	Pos	ND	68	156	0
607	D	1.2	2	5/14	Pos	Pos	76	114	0
638	D	2	2	1/24	Pos	Pos	67	148	0
655	D	2	3	ND	Pos	Pos	73	143	0
772	D	2.5	2	0/18	Pos	Pos	68	69	1
878	D/L	1.6	2	0/9	Pos	Neg	76	138	0
1279	D	2	2	0/12	Pos	Pos	68	102	0
1370	D	2	2	ND	Pos	Pos	73	61	0

Abbreviations: D, ductal; L, lobular; D/L. ductal and lobular features; pos, positive; neg, negative; ND, not determined; ER, estrogen receptor; PR, progesterone receptor; DFS, disease-free survival (number of months); status = 1, recurred; status = 0, disease-free.

Example 2

Identification of Differentially Expressed Genes

Gene expression profiling was performed using a 22,000-gene oligonucleotide microarray as described above. In the initial analysis, isolated RNA from frozen tumor-tissue sections taken from the archived primary biopsies were used. The resulting expression dataset was first filtered based on overall variance of each gene with the top 5,475 high-variance genes (75th percentile) selected for further analysis. Using this reduced dataset, t-test was performed on each gene comparing the tamoxifen responders and non-responders, leading to identification of 19 differentially expressed genes at the P value cutoff of 0.001 (Table 2). The probability of selecting this many or more differentially expressed genes by chance was estimated to be 0.04 by randomly permuting the patient class with respect to treatment outcome and repeating the t-test procedure 2,000 times. This analysis thus demonstrated the existence of statistically significant differences in gene expression between the primary breast cancers of tamoxifen responders and non-responders.

TABLE 2

19-gene signature identified by t-test in the Sections dataset

			Fold
Parametric	Mean in	Mean in	difference
p-value	responders	non-responders	of means	GB acc	Description

1	1.96E−05	0.759	1.317	0.576	AW006861	SCYA4 \| small inducible cytokine A4
2	2.43E−05	1.31	0.704	1.861	AI240933	ESTs
3	8.08E−05	0.768	1.424	0.539	X59770	IL1R2 \| interleukin 1 receptor, type II
4	9.57E−05	0.883	1.425	0.62	AB000520	APS \| adaptor protein with pleckstrin
						homology and src homology 2 domains
5	9.91E−05	1.704	0.659	2.586	AF208111	IL17BR \| interleukin 17B receptor
6	0.0001833	0.831	1.33	0.625	AI820604	ESTs
7	0.0001935	0.853	1.459	0.585	AI087057	DOK2 \| docking protein 2, 56 kD
8	0.0001959	1.29	0.641	2.012	AJ272267	CHDH \| choline dehydrogenase
9	0.0002218	1.801	0.943	1.91	N30081	ESTs, Weakly similar to I38022
						hypothetical protein [H. sapiens]
10	0.0004234	1.055	2.443	0.432	AI700363	ESTs
11	0.0004357	0.451	1.57	0.287	AL117406	ABCC11 \| ATP-binding cassette, sub-
						family C (CFTR/MRP), member 11
12	0.0004372	1.12	3.702	0.303	BC007092	HOXB13 \| homeo box B13
13	0.0005436	0.754	1.613	0.467	M92432	GUCY2D \| guanylate cyclase 2D,
						membrane (retina-specific)
14	0.0005859	1.315	0.578	2.275	AL050227	Homo sapiens mRNA; cDNA
						DKFZp586M0723 (from clone
						DKFZp586M0723)
15	0.000635	1.382	0.576	2.399	AW613732	Homo sapiens cDNA FLJ31137 fis, clone
						IMR322001049
16	0.0008714	0.794	1.252	0.634	BC007783	SCYA3 \| small inducible cytokine A3
17	0.0008912	2.572	1.033	2.49	X81896	C11orf25 \| chromosome 11 open reading
						frame 25
18	0.0009108	0.939	1.913	0.491	BC004960	MGC10955 \| hypothetical protein
						MGC10955
19	0.0009924	1.145	0.719	1.592	AK027250	Homo sapiens cDNA: FLJ23597 fis,
						clone LNG15281

To refine our analysis to the tumor cells and circumvent potential variability attributable to stromal cell contamination, the same cohort was reanalyzed following laser-capture microdissection (LCM) of tumor cells within each tissue section. Using variance based gene filtering and t-test screening identical to that utilized for the whole tissue section dataset, 9 differentially expressed gene sequences were identified with P<0.001 (Table 3).

TABLE 3

9-gene signature identified by t-test in the LCM dataset

1	2.67E−05	1.101	4.891	0.225	BC007092	HOXB13 \| homeo box B13
2	0.0003393	1.045	2.607	0.401	AI700363	ESTs
3	0.0003736	0.64	1.414	0.453	NM_014298	QPRT \| quinolinate
						phosphoribosyltransferase (nicotinate-
						nucleotide pyrophosphorylase
						(carboxylating))
4	0.0003777	1.642	0.694	2.366	AF208111	IL17BR \| interleukin 17B receptor
5	0.0003895	0.631	1.651	0.382	AF033199	ZNF204 \| zinc finger protein 204
6	0.0004524	1.97	0.576	3.42	AI688494	FLJ13189 \| hypothetical protein
						FLJ13189
7	0.0005329	1.178	0.694	1.697	AI240933	ESTs
8	0.0007403	0.99	1.671	0.592	AL157459	Homo sapiens mRNA; cDNA
						DKFZp434B0425 (from clone
						DKFZP434B0425)
9	0.0007739	0.723	1.228	0.589	BC002480	FLJ13352 \| hypothetical protein
						FLJ13352

Only 3 genes were identified as differentially expressed in both the LCM and whole tissue section analyses: the homeobox gene HOXB13 (identified twice as AI700363 and BC007092), the interleukin 17B receptor IL17BR (AF208111), and the voltage-gated calcium channel CACNA1D (AI240933). HOXB13 was differentially overexpressed in tamoxifen nonresponsive cases, whereas IL17BR and CACNA1D were overexpressed in tamoxifen responsive cases. Based on their identification as tumor-derived markers significantly associated with clinical outcome in two independent analyses, the utility of each of these genes was evaluated by itself and in combination with the others.
To define the sensitivity and specificity of HOXB13, IL17BR and CACNA1D expression as markers of clinical outcome, Receiver Operating Characteristic (ROC) analysis (Pepe, M. S. “An interpretation for the ROC curve and inference using GLM procedures.” Biometrics 56, 352-9 (2000)) was used. For data derived from whole tissue sections, the Area Under the Curve (AUC) values for IL17BR, HOXB13 and CACNAID were 0.79, 0.67 and 0.81 for IL17BR, HOXB13 and CACNA1D, respectively (see Table 4 and FIG. 1, upper portion). ROC analysis of the data generated from the microdissected tumor cells yielded AUC values of 0.76, 0.8, and 0.76 for these genes (see Table 4 and FIG. 1, lower portion).

TABLE 4

ROC analysis of using IL17BR, CACNA1D and HOXB13
expression to predict tamoxifen response

Tissue Sections

LCM

	AUC	P value	AUC	P value

IL17BR	0.79	1.58E−06	0.76	2.73E−05
CACNA1D	0.81	3.02E−08	0.76	1.59E−05
HOXB13	0.67	0.012	0.79	9.94E−07
ESR1	0.55	0.277	0.63	0.038
PGR	0.63	0.036	0.63	0.033
ERBB2	0.69	0.004	0.64	0.027
EGFR	0.56	0.200	0.61	0.068

AUC, area under the curve;
P values are AUC > 0.5.

A statistical test of significance indicated that these AUC values are all significantly greater than 0.5, the expected value from the null model that predicts clinical outcome randomly. Therefore, these three genes have potential utility for predicting clinical outcome of adjuvant tamoxifen therapy. As comparison, markers that are currently useful in evaluating the likelihood of response to tamoxifen were analyzed in comparison. The levels of ER (gene symbol ESR1) and progesterone receptor (PR, gene symbol PGR) are known to be positively correlated with tamoxifen response (see Fernandez, M. D., et al. “Quantitative oestrogen and progesterone receptor values in primary breast cancer and predictability of response to endocrine therapy.” Clin Oncol 9, 245-50 (1983); Ferno, M. et al. “Results of two or five years of adjuvant tamoxifen correlated to steroid receptor and S-phase levels.” South Sweden Breast Cancer Group, and South-East Sweden Breast Cancer Group. Breast Cancer Res Treat 59, 69-76 (2000); Nardelli, G. B., et al. “Estrogen and progesterone receptors status in the prediction of response of breast cancer to endocrine therapy (preliminary report).” Eur J Gynaecol Oncol 7, 151-8 (1986); and Osborne, C. K., et al. “The value of estrogen and progesterone receptors in the treatment of breast cancer.” U 46, 2884-8 (1980)).
In addition, growth factor signaling pathways (EGFR, ERBB2) are thought to negatively regulate estrogen-dependent signaling, and hence contribute to loss of responsiveness to tamoxifen (see Dowsett, M. “Overexpression of HER-2 as a resistance mechanism to hormonal therapy for breast cancer.” Endocr Relat Cancer 8, 191-5 (2001)). ROC analysis of these genes confirmed their correlation with clinical outcome, but with AUC values ranging only from 0.55 to 0.69, reaching statistical significance for PGR and ERBB2 (see Table 4).
The LCM dataset is particularly relevant, since EGFR, ERBB2, ESR1 and PGR are currently measured at the tumor cell level using either immunohistochemistry or fluorescence in situ hybridization. As individual markers of clinical outcome, HOXB13, IL17BR and CAC1D all outperformed ESR1, PGR, EGFR and ERBB2 (see Table 4).

Example 3

Identification of the HOXB13:IL17BR Expression Ratio

HOXB13:IL17BR expression ratio was identified as a robust composite predictor of outcome as follows. Since HOXB13 and IL17BR have opposing patterns of expression, the expression ratio of HOXB13 over IL17BR was examined to determine whether it provides a better composite predictor of tamoxifen response. Indeed, both t-test and ROC analyses demonstrated that the two-gene ratio had a stronger correlation with treatment outcome than either gene alone, both in the whole tissue sections and LCM datasets (see Table 5). AUC values for HOXB13:IL17BR reached 0.81 for the tissue sections dataset and 0.84 for the LCM dataset. Pairing HOXB13 with CACNA1D or analysis of all three markers together did not provide additional predictive power.

TABLE 5

HOXB13:IL17BR ratio is a stronger predictor
of treatment outcome

t-test

ROC

		t-statistic	P value	AUC	P value

Tissue	IL17BR	4.15	1.15E−04	0.79	1.58E−06
Section	HOXB13	−3.57	1.03E−03	0.67	0.01
	HOXB13:IL17BR	−4.91	1.48E−05	0.81	1.08E−07
	IL17BR	3.70	5.44E−04	0.76	2.73E−05
LCM	HOXB13	−4.39	8.00E−05	0.79	9.94E−07
	HOXB13:IL17BR	−5.42	2.47E−06	0.84	4.40E−11

AUC, area under the curve;
P values are AUC > 0.5.

The HOXB13/IL7BR ratio was compared to well-established prognostic factors for breast cancer, such as patient age, tumor size, grade and lymph node status (see Fitzgibbons, P. L. et al. “Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999.” Arch Pathol Lab Med 124, 966-78 (2000)). Univariate logistic regression analysis indicated that only tumor size was marginally significant in this cohort (P=0.04); this was not surprising given that the responder group was closely matched to the non-responder group with respect to tumor size, tumor grade and lymph node status during patient selection. Among the known positive (ESR1 and PGR) and negative (ERBB2 and EGFR) predictors of tamoxifen response, ROC analysis of the tissue sections data indicated that only PGR and ERBB2 were significant (see Table 4). Therefore, a comparison of logistic regression models containing the HOXB13:IL17BR ratio either by itself or in combination with tumor size, and expression levels of PGR and ERBB2, were made (see Table 6). The HOXB13:IL17BR ratio alone was a highly significant predictor (P=0.0003) and had an odds ratio of 10.2 (95% CI 2.9-35.6). In the multivariate model, HOXB13:IL17BR ratio is the only significant variable (P=0.002) with an odds ratio of 7.3 (95% CI 2.1-26). Thus, the expression ratio of HOXB13:IL17BR is a strong independent predictor of treatment outcome in the setting of adjuvant tamoxifen therapy.

TABLE 6

Logistic Regression Analysis

Univariate Model

Predictor	Odds Ratio	95% CI	P Value

HOXB13:IL17BR	10.17	2.9-35.6	0.0003

Multivariate Model

Predictors	Odds Ratio	95% CI	P Value

Tumor size	1.5	0.7-3.5	0.3289
PGR	0.8	0.3-1.8	0.5600
ERBB2	1.7	0.8-3.8	0.1620
HOXB13:IL17BR	7.3	2.1-26.3	0.0022

All predictors are continuous variables. Gene expression values were from microarray measurements. Odds ratio is the inter-quartile odds ratio, based on the difference of a predictor from its lower quartile (0.25) to its upper quartile (0.75);
CI, confidence interval.

Example 4

Independent Validation of HOXB13:IL17BR Expression Ratio

The reduction of a complex microarray signature to a two-gene expression ratio allows the use of simpler detection strategies, such as real-time quantitative PCR (RT-QPCR) analysis. The HOXB13:IL17BR expression ratio by RT-QPCR using frozen tissue sections that were available from 59 of the 60 training cases were analyzed (FIG. 2, part a). RT-QPCR data were highly concordant with the microarray data of frozen tumor specimens (correlation coefficient r=0.83 for HOXB13, 0.93 for IL17BR). In addition, the PCR-derived HOXB13:IL17BR ratios, represented as ΔCTs, where CT is the PCR amplification cycles to reach a predetermined threshold amount (e.g., FIG. 2, parts a and b) and ΔCT is the CT difference between HOXB13 and IL17BR, were highly correlated with the microarray-derived data (r=0.83) and with treatment outcome (t test P=0.0001, FIG. 2, part c). Thus, conventional RT-QPCR analysis for the expression ratio of HOXB13 to IL17BR appears to be equivalent to microarray-based analysis of frozen tumor specimens.
To validate the predictive utility of HOXB13:IL17BR expression ratio in an independent patient cohort, 20 additional ER-positive early-stage primary breast tumors from women treated with adjuvant tamoxifen only at MGH between 1991 and 2000, and for which medical records and paraffin-embedded tissues were available, were identified. Of the 20 archival cases, 10 had recurred with a median time to recurrence of 5 years, and 10 had remained disease-free with a median follow up of 9 years (see Table 7 for details).

TABLE 7

Patient and tumor characteristics of the validation set.

	Tumor
Sample	Type	Size	Grade	Nodes	ER	PR	Age	DFS	Status

Test 1	D	1.9	3	0/10	Pos	Pos	69	15	1
Test 2	D	1.7	3	0/19	Pos	Pos	61	117	1
Test 3	D	1.7	2	0/26	Pos	ND	65	18	1
Test 4	D	1.2	2	0/19	Pos	Pos	63	69	1
Test 5	D	1.7	2	2/2	Pos	Pos	60	52	1
Test 6	D	1.1	1	0/10	Pos	Pos	54	59	1
Test 7	D	>1.6	2	0/17	Pos	Neg	66	32	1
Test 8	L	2.6	1-2	0/14	Pos	Pos	58	67	1
Test 9	D	1.2	2	ND	Pos	Pos	93	58	1
Test 10	D	4	3	0/20	Pos	Pos	66	27	1
Test 11	D	1.1	2	0/19	Pos	Pos	64	97	0
Test 12	D	2.7	2	0/10	Pos	Pos	66	120	0
Test 13	D	0.9	1	0/22	Pos	Pos	66	123	0
Test 14	D	2.1	2	0/16	Pos	Pos	57	83	0
Test 15	D	0.8	1-2	0/8	Pos	Pos	74	80	0
Test 16	D	1	2	0/13	Pos	Pos	74	93	0
Test 17	D	1.6	2	0/29	Pos	Pos	66	121	0
Test 18	L	1.5	1-2	0/8	Pos	Pos	65	25	0
Test 19	D	1.5	3	0/16	Pos	Pos	60	108	0
Test 20*	L	4	1-2	0/19	Pos	Pos	60	108	0

Abbreviations: Same as supplemental Table 1.
*Patient received tamoxifen for 2 years.

RNA was extracted from formalin-fixed paraffin-embedded (FFPE) whole tissue sections, linearly amplified, and used as template for RT-QPCR analysis. Consistent with the results of the training cohort, the HOXB13:IL17BR expression ratio in this independent patient cohort was highly correlated with clinical outcome (t test P=0.035) with higher HOXB13 expression (lower ΔCTs) correlating with poor outcome (FIG. 2, part d). To test the predictive accuracy of the HOXB13:IL17BR ratio, the RT-QPCR data from the frozen tissue sections (n=59) was used to build a logistic regression model. In this training set, the model predicted treatment outcome with an overall accuracy of 76% (P=0.000065, 95% confidence interval 63%-86%). The positive and negative predictive values were 78% and 75%, respectively. Applying this model to the 20 independent patients in the validation cohort, treatment outcome for 15 of the 20 patients was correctly predicted (overall accuracy 75%, P=0.04, 95% confidence interval 51%-91%), with positive and negative predictive values of 78% and 73%, respectively.
Kaplan-Meier analysis of the patient groups as predicted by the model resulted in significantly different disease-free survival curves in both the training set and the independent test set (FIG. 2, parts e and f).

ADDITIONAL REFERENCES

Ma, X. J. et al. Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA 100, 5974-9 (2003).

Nicholson, R. I. et al. Epidermal growth factor receptor expression in breast cancer: association with response to endocrine therapy. Breast Cancer Res Treat 29, 117-25 (1994).

All references cited herein, including patents, patent applications, and publications, are hereby incorporated by reference in their entireties, whether previously specifically incorporated or not.
Having now fully described this invention, it will be appreciated by those skilled in the art that the same can be performed within a wide range of equivalent parameters, concentrations, and conditions without departing from the spirit and scope of the invention and without undue experimentation.
While this invention has been described in connection with specific embodiments thereof, it will be understood that it is capable of further modifications. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains and as may be applied to the essential features hereinbefore set forth.


Appendix

Sequences identified as those of IL17BR cluster

Aw675096

CCGGCGATGTCGCTCGTGCTGCTAAGCCTGGCCGCGCTGTGCAGGAGCGCCGTACCCCGA

GAGCCGACCGTTCAATGTGGCTCTGAAACTGGGCCATCTCCAGAGTGGATGCTACAACAT

GATCTAATCCCGGGAGACTTGAGGGACCTCCGAGTAGAACCTGTTACAACTAGTGTTGCA

ACAGGGGACTATTCAATTTTGATGAATGTAAGCTGGGTACTCCGGGCAGATGCCAGCATC

CGCTTGTTGAAGGCCACCAAGATTTGTGTGACGGGCAAAAGCAACTTCCAGTCCTACAGC

TGTGTGAGGTGCAATTACACAGAGGCCTTCCAGACTCAGACCAGACCCTCTGGTGGTAAA

TGGACATTTTCCTACATCGGCTTCCCTGTAGAGCTGAACACAGTCTATTTCATTGGGGCC

CATAATATTCCTAATGCAAATATGAATGAAGATGGCCCTTCCATGTCTGTGAATNTCACC

TCACCAGGCTGCCTAGACCACATAATGAAATATAAAAAAAAGTGTGTCAAGGCCGGAAGC

CTGTGGGATCCGAACATCACT

Aw673932

TTTTTTTTTTTTTTTTTTTAAAAGTGGGTTCAGCTTGTTTATTCCCTACTTTTGTTATCT

TAAAAACAATGATTTTTTGCATGTAATAGAAGGTTTTTCACTTAAGATGCTATTGAGTGA

ATCAGTGAGGGGTTCTTAGAGTTAGTATTCATTAATTAAACATAGAATATTAGCTAAACA

GTTCTGGGTACACTGCAATGCATGGTCTATGGAAGACTAGATGTTTGGCTGAAGATGCTT

TATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTGTAATTGATTTCTATGT

ATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTTAATGCTACATTAGTT

AGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCTGTTTGTAGGC

TGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGG

BC000980

ggcccggcga tgtcgctcgt gctgctaagc ctggccgcgc tgtgcaggag cgccgtaccc

cgagagccga ccgttcaatg tggctctgaa actgggccat ctccagagtg gatgctacaa

catgatctaa tcccgggaga cttgagggac ctccgagtag aacctgttac aactagtgtt

gcaacagggg actattcaat tttgatgaat gtaagctggg tactccgggc agatgccagc

atccgcttgt tgaaggccac caagatttgt gtgacgggca aaagcaactt ccagtcctac

agctgtgtga ggtgcaatta cacagaggcc ttccagactc agaccagacc ctctggtggt

aaatggacat tttcctacat cggcttccct gtagagctga acacagtcta tttcattggg

gcccataata ttcctaatgc aaatatgaat gaagatggcc cttccatgtc tgtgaatttc

acctcaccag gctgcctaga ccacataatg aaatataaaa aaaagtgtgt caaggccgga

agcctgtggg atccgaacat cactgcttgt aagaagaatg aggagacagt agaagtgaac

ttcacaacca ctcccctggg aaacagatac atggctctta tccaacacag cactatcatc

gggttttctc aggtgtttga gccacaccag aagaaacaaa cgcgagcttc agtggtgatt

ccagtgactg gggatagtga aggtgctacg gtgcagctga ctccatattt tcctacttgt

ggcagcgact gcatccgaca taaaggaaca gttgtgctct gcccacaaac aggcgtccct

ttccctctgg ataacaacaa aagcaagccg ggaggctggc tgcctctcct cctgctgtct

ctgctggtgg ccacatgggt gctggtggca gggatctatc taatgtggag gcacgaaagg

atcaagaaga cttccttttc taccaccaca ctactgcccc ccattaaggt tcttgtggtt

tacccatctg aaatatgttt ccatcacaca atttgttact tcactgaatt tcttcaaaac

cattgcagaa gtgaggtcat ccttgaaaag tggcagaaaa agaaaatagc agagatgggt

ccagtgcagt ggcttgccac tcaaaagaag gcagcagaca aagtcgtctt ccttctttcc

aatgacgtca acagtgtgtg cgatggtacc tgtggcaaga gcgagggcag tcccagtgag

aactctcaag acctcttccc ccttgccttt aaccttttct gcagtgatct aagaagccag

attcatctgc acaaatacgt ggtggtctac tttagagaga ttgatacaaa agacgattac

aatgctctca gtgtctgccc caagtaccac ctcatgaagg atgccactgc tttctgtgca

gaacttctcc atgtcaagca gcaggtgtca geaggaaaaa gatcacaagc ctgccacgat

ggctgctgct ccttgtagcc cacccatgag aagcaagaga ccttaaaggc ttcctatccc

accaattaca gggaaaaaac gtgtgatgat cctgaagctt actatgcagc ctacaaacag

ccttagtaat taaaacattt tataccaata aaattttcaa atattgctaa ctaatgtagc

attaactaac gattggaaac tacatttaca acttcaaagc tgttttatac atagaaatca

attacagttt taattgaaaa ctataaccat tttgataatg caacaataaa gcatcttcag

ccaaacatct agtcttccat agaccatgca ttgcagtgta cccagaactg tttagctaat

attctatgtt taattaatga atactaactc taagaacccc tcactgattc actcaatagc

atcttaagtg aaaaaccttc tattacatgc aaaaaatcat tgtttttaag ataacaaaag

tagggaataa acaagctgaa cccactttta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa

aa

BI602183

AGCGGAGCTGCGGGTGGCCTGGATCCCGCGCAGTGGCCCGGCGATGTCGCTCGTGCTGCT

AAGCCTGGCCACGCTGTGCAGGAGCGCCGTACCCCGAGAGCCGACCGTTCAATGTGGCTC

TGAAACTGTGGACATTTTCCTATATCGGCTTCCCTGTAGAGCTGAAAACAGTCTATTTCA

TTGGGGCCCATAATATTCCTAATGCAAATATGAATGAAGATGGCCCTTCCATGTCTGTGA

ATTTCACCTCACCAGGCTGCCTAGACCACATAATGAAATATAAAAAAAGTGTGTCAAGGC

CGGAAGCCTGTGGGATCCGAACATCACTGCTTGTAAGAAGAATGAGGAGACAGTAGAAGT

GAACTTCACAACCACTCCCCTGGGAAACAGATACATGGCTCATCCAACACAGCACTATCA

TCGGGTTTTCTCAGGTGTTTGAGCCACACCAGAAGAAACAAACGCGAGCTTCAGTGGTGA

TTCCAGTGACTGGGGATAGTGAAGGTGCTACGGTGCAGCTGACTCCATATTTTCCTACTT

GTGGCAGCGACTGCATCCGACATAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGTCC

CTTTCCCCTCTGGATAACAACAAAAGCAAGCCGGGAGGCTGGCTGCCTCTCCTCCTGCTG

TCTCTGCTGGTTGGCCACATTGGGTGCTGGTGGCAGGGATCTATCTAATGTGGAGGCACG

AAAGGATCCAGAAGACTTCCTTTTCTACCACAAACTACTGCCCCCATTAAGGTCCTGTGG

TTACCCATCTTGAAATATGTTCCTCACACAATTTGTTACTTCACTGAATTCTTCAAAACC

TG

BI458542

AGCGGAGCGTGCGGGTGGCCTGGATCCCGCGCAGTGGCCCGGCGATGTCGCTCGTGCTGC

TAAGCCTGGCCACGCTGTGCAGGAGCGCCGTACCCCGAGAGCCGACCGTTCAATGTGGCT

CTGAAACTGTGGACATTTTCCTATATCGGCTTCCCTGTAGAGCTGAAAACAGTCTATTTC

ATTGGGGCCCATAATATTCCTAATGCAAATATGAATGAAGATGGCCCTTCCATGTCTGTG

AATTTCACCTCACCAGGCTGCCTAGACCACATAATGAAATATAAAAAAAAGTGTGTCAAG

GCCGGAAGCCTGTGGGATCCGAACATCACTGCTTGTAAGAAGAATGAGGAGACAGTAGAA

GTGAACTTCACAACCACTCCCCTGGGAAACAGATACATGGCTCATCCAACACAGCACTAT

CATCGGGTTTTCTCAGGTGTTTGAGCCACACCAGAAGAAACAAACGCGAGCTTCAGTGGT

GATTCCAGTGACTGGGGATAGTGAAGGTGCTACGGTGCAGCTGACTCCATATTTTCCTAC

TTGTGGCAGCGACTGCATCCGACATAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGT

CCCTTTCCCTCTGGATAACAACAAAAGCAAGCCGGGAGGCTGGCTGCCTCTCCTCCTGCT

GTCTCTGCTGGTGGNCACATTGGGTGCTGGTGGCAGGGATCTATCTAATGTGGAGGCACG

AAAGGATCAGAAGACTTCCTTTTCTACCACCACATACTGCCCCCCATTAAGGTTCTTGTG

GTTTACCC

BI823321

GGCGATGTCGCTCGTGCTGCTAAGCCTGGCCGCGCTGTGCAGGAGCGCCGTACCCCGAGA

GCCGACCGTTCAATGTGGCTCTGAAACTGGGCCATCTCCAGAGTGGATGCTACAACATGA

TCTAATCCCGGGAGACTTGAGGGACCTCCGAGTAGAACCTGTTACAACTAGTGTTGCAAC

AGGGGACTATTCAATTTTGATGAATGTAAGCTGGGTACTCCGGGCAGATGCCAGCATCCG

CTTGTTGAAGGCCACCAAGATTTGTGTGACGGGCAAAAGCAACTTCCAGTCCTACAGCTG

TGTGAGGTGCAATTACACAGAGGCCTTCCAGACTCAGACCAGACCCTCTGGTGGTAAATG

GACATTTTCCTATATCGGCTTCCCTGTAGAGCTGAACACAGTCTATTTCATTGGGGCCCA

TAATATTCCTAATGCAAATATGAATGAAGATGGCCCTTCCATGTCTGTGAATTTCACCTC

ACCAGGAAGCCTGTGGGATCCGAACATCACTGCTTGTAAGAAAGAATGAGGAGACAGTAG

AAGTGAACTTCACAACCACTCCCCTGGGAAACAGATACATGGCTCTTATCCAACACAGCA

CTATCATCGGGTTTCTCAGGTGTTTGAGCCACACCAGAAGAAACAAACGCGAGCTTCAGT

GGTGATTCCAGTGACTGGGGATAGTGAAGGTGCTACGGTGCAGCTGACTCCATATTTTCC

TACTTGTGGCAGCGACTGCAATCCGACATAAAGGAACAGTTGTGCTCTGCCCACAAACAG

GCGTCCCTTTCCCTCTTGGATAGCAACAGAAGCAAGCCGGGAGGCTGGTGCCTCTTCTTC

TGGTGTCTCTGCTGGTGGCACATTGAGTGCTGGTGGCAGGATCCATCTAATGTGGAGGCC

CCAAAGGACCAGGAAAGACTTCCTTTATTAGCACCAAGTATTGCCC

AA514396

TGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTGT

AATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTT

AATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTA

AGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATT

GGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCA

GCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTACTTGACATGGAGAAG

TTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGC

ATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATG

AATCTGGC

BF110326

TTTGTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAA

AACTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCG

TTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAA

TTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCT

GTAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTTTCATGGGTGGGCTACAAGGA

GCAGCAbCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATG

GAGAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACT

GAGAGCATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTG

CAGATGAATCTGGCTTCTTAGATCACTGC

BE466508

TGGCATGAGATGCTATATTGTTGCATTATCAAAATGGGTTTAGTCTTCAATTAACACTGT

AATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTGGTTTCCAATCGTCAGTT

AATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTA

AGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATT

GGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCA

GCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAG

TTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGC

ATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATG

AATCTGGCTTCTTAGATCACTG

BF740045

GTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAAC

TGTAATTGATTTCTATGTATAAAACACGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTT

AGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATT

ACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGT

AATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGC

AGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGA

GAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGA

GAGCATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTA

AW299271

TGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTGT

AATTGATTTCTATGTATAAAACAGCGTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTT

AATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTA

AGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATT

GGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCA

GCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAG

TTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGC

ATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATG

AATCTGGCTTCTTAGATCACTGCAGAAAAG

AA836217

TTTTTTTTTTACAACTTCAAAGCTGTTTTATACATAGAAATCAATTACAGTTTTAATTGA

AAACTATAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCAAACATCTAGTCTTC

CATAGACCATGCATTGCAGTGTACCCAGAACTGTTTAGCTAATATTCTATGTTTAATTAA

TGAATACTAACTCTAAGAACCCCTCACTGATTCACTCAATAGCATCTTAAGTGAAAAACC

TTCTATTACATGCAAAAAATCATTGTTTTTAAGATAACAAAAGTAGGGAATAAACAAGCT

GAACCCACTTTTACTGGACCAAATGATCTATTATATGTGTACCACTTGTATGATTTGGTA

TTTGCATAAGACCTTCCCTCTACAAACTAGATTCATATCTTGATTCTTGTACAGGTGCCT

TTTAACATGAACAACAAAATACCCACAAACTTGTCTACTTTTGCC

AI203628

TAGTAATTAAAACATTTTATACCAATAAAATTTTCAAATATTGCTAACTAATGTAGCATT

AACTAACGATTGGAAACTACATTTACAACTTCAAAGCTGTTTTATACATAGAAATCAATT

ACAGTTTTAATTGAAAACTATAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCA

AACATCTAGTCTTCCATAGACCATGCATTGCAGTGTACCCAGAACTGTTTAGCTAATATT

CTATGTTTAATTAATGAATACTAACTCTAAGAACCCCTCACTGATTCACTCAATAGCATC

TTAAGTGAAAAACCTTCTATTACATGCAAAAAATCATTGTTTTTAAGATAACAAAAGTAG

GGAATAAACAAGCTGAACCCACTTTTACTGGACCAAATGATCTATTATATGTGTAACCAC

TTGTATGATTTGGTATTTGCATAAGACCTTCCCTCTACAAACTAGATTCATATCTTGATT

CTTGTACAGGTGCCTTTTAACATGAA

AI627783

TTTTTTTTTTTTTTTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACT

AAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAAT

TGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGC

AGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTACTTGACATGGAGAA

GTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAG

CATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGAT

GAATCTGGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAG

AGTTCTC

AI744263

TTAAAGTGGGTTCAGCTTGTTTATTCCCTACTTTTGTTATCTTAAAAACAATGATTTTTT

GCATGTAATAGAAGGTTTTTCACTTAAGATGCTATTGAGTGAATCAGTGAGGGGTTCTTA

GAGTTAGTATTCATTAATTAAACATAGAATATTAGCTAAACAGTTCTGGGTACACTGCAA

TGCATGGTCTATGGAAGACTAGATGTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAA

ATGGTTACAGTTTTCAATTAAAGCTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGT

TGTAAATGTAGTTTCCAATCGTTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTT

TATTGGTATAAAATGTTTTAATTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGG

ATCATCACACGTTNTTTCCCTGTAATTGGTGGGATAGGAAGCCTTTA

AI401622

AGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCTGTTTGT

AGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTGGGATAGG

AAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCATCGTGGC

AGGCTTGTGATCTTTTTCCTGCTGACACCTGCTACTTGACATGGAGAAGTTCTGCACAGA

AAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGTAATCGT

CTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATGAATCTGGCTTC

TTAGATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAGAGTTCTCACTGG

AI826949

TTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTG

TAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGT

TAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACT

AAGGCTGTTTGTAGGCTTGCATAGAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAAT

TGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGC

AGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAA

GTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAG

CATTGTAATCGTCT

BE047352

TTTTTTTTTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCT

GTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTGG

GATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCAT

CGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTACTTGACATGGAGAAGTTCTG

CACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGT

AATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATGAATCT

GGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAGAG

AI911549

TTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAGTTTTCAATTAAAGCT

GTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAG

TTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTAC

TAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAA

TTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAG

CAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGA

AGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACA

BF194822

TTCTCTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAGTTTTCAATTAAA

GCTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGT

TAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAAT

TACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTG

TAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAG

CAGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGG

AGAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGG

AI034244

TTTTTTTTTTTTTTTTACAACCTTGAAAGCTGTTTTATACATAGAAATCAATTACAGTTT

TAATTGAAAACTATAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCAAACATCT

AGTCTTCCATAGACCATGCATTGCAGTGTACCCAGAACTGTTTAGCTAATATTCTATGTT

TAATTAATGAATACTAACTCTAAGAACCCCTCACTGATTCACTCAATAGCATCTTAAGTG

AAAAACCTTCTATTACATGCAAAAAATCATTGTTTTTAAGATAACAAAAGTAGGGAATAA

ACAAGCTGAACCCACTTTTACTGGACCAAATGATCTATTATATGTGTAACCACTTGTATG

ATTTGGATTTGCATAAGACCTTCCCTCTACAAACTAGATTCATATCTTGATTCT

AI033911

TTTTTTTTTTTTTTTTACAACTGCAAAGCTGTTTTATACATAGAAATCAATTACAGTTTT

AATTGAAAACTATAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCAAACATCTA

GTCTTCCATAGACCATGCATTGCAGTGTACCCAGAACTGTTTAGCTAATATTCTATGTTT

AATTAATGAATACTAACTCTAAGAACCCCTCACTGATTCACTCAATAGCATCTTAAGTGA

AAAACCTTCTATTACATGCAAAAAATCATTGTTTTTAAGATAACAAAAGTAGGGAATAAA

CAAGCTGAACCCACTTTTACTGGACCAAATGATCTATTATATGTGTAACCACTTGTATGA

TTTGGTATTTGCATAAGACCTTCCCTCTACAAACTAGATTCATATCTTGATTCT

BF064177

TTTTTTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCT

GTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTGG

GATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCAT

CGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTACTTGACATGGAGAAGTTCTG

CACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGT

AATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATGAATCT

GGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAGAGTTCT

CACTGGGACTGCCCTCGCTCTTGCCACAGGTACCATCGCACACACTGTTGACGTCATTGG

AAAG

AA847767

GGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTGTA

ATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTTA

ATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAA

GGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTG

GTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAG

CCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGT

TCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTA

AI538624

TTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAGTTTTCAATTAAAGCTG

TAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGT

TAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACT

AAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAAT

TGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGC

AGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAA

GTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTAC

AI913613

TTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTG

TAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGT

TAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACT

AAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTNTTTCCCTGTAAT

TGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGC

AGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAA

GTTCTGCACAGAAAGCAGTGGCATCCTTCATG

AI942234

GTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAAC

TGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTA

GTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTA

CTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTA

ATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCA

GCAGCCATCGTGGCAGCTTGGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGAAG

AAGTTCTGCACAGAAAGCAGTGGCAT

AI580483

GTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAAC

TGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTA

GTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTA

CTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTA

ATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCA

GCAGCCATCGTGGCAGGCTTGGATCTTTTTCCTGCTGACACCTGCTGCTTGACATTGGAA

AGTTCTGCACAGAAAGCAGTGGCATC

AI831909

TTTTGGCTGATGATGCTTTATTGTTGCATTATCAAAATGGTTACAGTTTTCAATTAAAGC

TGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTA

GTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTA

CTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTA

ATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCA

GCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAG

AAGTTCTGCACAGAAAGCAGTGGCAT

AI672344

GGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAGTTTTCAATTAAAGCTGTA

ATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTTA

ATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAA

GGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTG

GTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAG

CCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGT

TCTGCACAGAAAG

AW025192

GATTGGCTGTTTTATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAA

CTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTT

AGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATT

ACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGT

TATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGC

AGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGA

GAAGTTCTGCACAAAAAGCAGTGGCATCCTTCATGAGGTGGTA

AA677205

GCAATATTTTAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCTGTTTGTAGGCT

GCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTGGCATAGGAAGCC

TTTAAGGTCTCTTGCTTCTCATGGTGTGGGCTACAAGGAGCAGCAGCCATCGTGGCAGGC

TTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGTTCTGCACAGAAAGC

AGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGTAATCGTCTTT

TGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATGAATCTGGCTTCTTAG

ATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAGAGTTCTCACTGGGACT

GCCCTCGCTCTTGCCACAGGTACCATCGCACACACTG

AA721647

TTTTTTTTTTACAACTTCAAAGCTGTTTTATACATAGAAATCAATTACAGTTTTAATTGA

AAACTATAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCAAACATCTAGTCTTC

CATAGACCATGCATTGCAGTGTACCCAGAACTGTTTAGCTAATATTCTATGTTTAATTAA

TGAATACTAACTCTAAGAACCCCTCACTGATTCACTCAATAGCATCTTAAGTGAAAAACC

TTCTATTACATGCAAAAAATCATTGTTTTTAAGATAACAAAAGTAGGGAATAAACAAGCT

GAACCCACTTTTACTGGACCAAATGATCTATTATATGTGTAACCACTTGTATGATTTGGT

ATTTG

BF115018

GTTTCGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAAC

TGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTA

GTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTA

CTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTAAGGCCCATCACACGTTTTTTCCCTGTA

ATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTNTCATGGGTGGGCTACAAGGAGCA

GCAGCCATCGTGGCAGGCTTGNGATCTTTTTCCTGCTGGCCCCTGCTGCTTGACAT

W61238

NAAAGCACTGGCTGAAGGAAGCCAAGAGGATCACTGCTGCTCCTTTTTTCTAGAGGAAAT

GTTTGTCTACGTGGTAAGATATGACCTAGCCCTTTTAGGTAAGCGAACTGGTATGTTAGT

AACGTGTACAAAGTTTAGGTTCAGACCCCGGGAGTCTTGGGCACGTGGGTCTCGGGTCAC

TGGTTTTGACTTTAGGGCTTTGTTACAGATGTGTGACCAAGGGGAAAATGTGCATGACAA

CACTAGAGGTATGGGCGACACGANAACGAACGGGAAGTTTTGGCTGAAGTAGGAGTCTTG

GTGAGATTTTGCTCTGATGCATGGTGTGAACTTTCTGAGCCTCTTGTTTTTCCTCAAGCT

GACTCCATATTTTCCTACTTGTGGCAGCGACTGCATCCGACATAAAGGAACAG

W61239

TAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCTGTTTGTAGG

CTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTGGGATAGGAAG

CCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCATCGTGGCAGG

CTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGTTCTGCACAGAAAG

CAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGTAATCGTCTT

TTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATGAATCTGGCTTCTTA

GATCACTGCAGAAAAGGTTAAAGGCAAGGGGGGA

AI032064

AGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCTGTTTGTAGGC

TGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTGGCATAGGAAGC

CTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCATCGTGGCAGGC

TTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGTTCTGCACAGAAAGC

AGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGTAATCGTCTTT

TGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATGAATCTGGCTTCTTAG

ATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAGAGTTCTCACTGGGACT

GCCCTCGCTCTTGCCAC

AW236941

TTTTTTTTTTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGC

TGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTG

GGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCA

TCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGTTCT

GCACAAAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTG

TAATCGTCTTTTGTATCAATC

AW236941

TTTTTTTTTTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGC

TGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATTGGTG

GGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCA

TCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGTTCT

GCACAAAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTG

TAATCGTCTTTTGTATCAATC

BG057174

TTTTATACATAGAAATCAATTACAGCTTTAATTGAAAACTATAACCATTTTGATAATGCA

ACAATAAAGCATCTTCAGCCAAACATCTAGTCTTCCATAGACCATGCATTGCAGTGTACC

CAGAACTGTTTAGCTAATATTCTATGTTTAATTAATGAATACTAACTCTAAGAACCCCTC

ACTGATTCACTCAATAGCATCTTAAGTGAAAAACCTTCTATTACATGCAAAAAATCATTG

TTTTTAAGATAACAAAAGTAGGGAATAAACAAGCTGAACCCACTTTTACTGGACCAAATG

ATCTATTATATGTG

AW058532

GGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTGTA

ATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTTA

ATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAA

GGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCCTGTATGG

GTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCT

T98360

TNAGGAANGAGAAGAAGCGAGATNNANNTNNAGAAATANGTGGTGGCNTANTTTAGAGAG

ATTGATNCAAAAGCNGATTNCAATNNNCTCAGTGNCTNCCCAAGTNCCNCCTCATGAAGG

ATNCACTNCTTTCTGTGCAGACTNNNCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGAN

CACAAGCTCCNCGATGGCTGCTGCTCCTTGTAGCCCNCCATGAGAAGCAAGAGNCTTAAA

GGCTTCCTATCCCACCAATTACAGGGAAAAACGTGTGATGACCTGAGCTTACTATGCAGC

CTACAANCAGCCTTAGTAATTAAACCNTTTATT

T98361

NANNATGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAGTTTTCAATTAAAGCTG

TAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGT

TAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGNATAAAATGTTTTAATTACT

AAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTNCCCTGTAAT

TGGGTGGGGATAGGGAAGCCCTTTAAGGGTCTCTTGCTTCTCATGGGGTGGGGCCTACNA

AGGGAGCAGCCAGCCCATCGTGGCCAGGGCCTTGTGGANCCTTTTTCCCTGCCTGGACAC

CCTGCCTGCCTTGGACCATGGGGAGGAAGGTTCTGGCACCAGGAAAGCCAGGTGGCCCAT

CCCTTCCATGAGGGTGGGGTACTTNGGGGGGCCAGGACCACTGAGGNGCCATTGGTAATC

CGTCCTTTTNGTATCCAATCCCCTCCTAAGGTAGGNCCCCCC

AI470845

TTTTGTGGGTTCAGCTTGTTTATTCCCTACTTTTGTTATCTTAAAAACAATGATTTTTTG

CATGTAATAGAAGGTTTTTCACTTAAGATGCTATTGAGTGAATCAGTGAGGGGTTCTTAG

AGTTAGTATTCATTAATTAAACATAGAATATTAGCTAAACAGTTCTGGGTACACTGCAAT

GCATGGTCTATGGAAGACTAGATGTTTGGCTGAAGATGCTTTTATTGTTGCATTATCAAN

ATGGTTTATAGTTTTCAATTAAAACTGTAATTGATTT

AI497731

GGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTGTA

ATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTTA

ATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAA

GGCTGTTTGTAGGCTGCATAGTAAGCTTAANGATCATACNCACGTTTTTCCCTGAATTTG

GTGGGATAANGAAGCCTTTAAAGGT

T96629

TTGAAAATTTTATTGGNATAAAATGTTTTAATTACTAAGGCTGTTTGTAGGCTGCATAGT

AAGCTTCAGGANCATCACACGTTTTTTCCCTGTAATTGGTGGCATAGGAAGCCTTTAAGG

TCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCATCGTGGCAGGCTTGTGATC

TTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGTTCTGCACAGAAAGCAGTGGCAT

CCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGTAATCGTCTTTTGTATCAA

TCTCTCTAAAGTAGACCACCACCGTNTTTGTGCAGATGGANTCTGGCTTC

T96740

AGGCACTATCATCGGGTTTTCTCAGGTGTTTGAGCCACACCAGAAGAAACAAACGCGAGC

TTCAGTGGTGATTCCAGTGACTGGGGATAGTGAAGGTGCTACGGTGCAGCTGACTCCATA

TTTTCCTACTTGTGGCAGCGACTGCATCCGACATAAAGGAACAGTTGTGCTCTGCCCACA

AACAGGCGTCCCTTTCCCTCTGGATAACAACAAAAGCAAGCCGGGANGGNCTGNCCTCTC

CTCCTGCTGTCTCTGCTGGTGGCCACATGGGTGCTGGTGGCAGGGATCTATCTAATGTGG

AGGCACGAAAGGATCAAGAAGACTTCCTTTTCTAACCACCACATTACTGCCCCCCATTTA

AGGTTCTTGTGGTTTTACCCATCTGGAAATATGTTTTCCCTTCACACATTTGTTTATTTC

ATTGATTTNTTTCAAAACCTTGGCAGGAGTTT

H25975

GGGTCCAGTGCAGTGGCTTGCNTGCAGAAAGAAGGCAGCAGACAAAGTCGTCTTCCTTCT

TTCCAATGACGTCAACAGTGTGTGCGATGGTACCTGTGGCAAGAGCGAGGGCAGTCCCAG

TGAGAACTCTCAAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAAG

CCAGATTCATCTGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACGA

TTACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCCACTGCTTTCTG

TGCAGAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGATTCACAAGCCTGCC

ACGATGGCTGCTTGCTTCCTTTGTAGCCCACCCATGAGGAAGNCAAGAGACCTTNAAAGG

GTTCCTTTTCCCATCANTTTACAGGGGANAAAACGTGTGATGATC

H25941

TTTTGTTTGGCTNATNTNNTTCTTATTGTTGCATTATCAAAATGGTTATAGTTTTCAATT

AAAACTGTAATTGATTNCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAAT

CGTTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAANGTTTT

AATTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTCCC

CTGTAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTNGCTTCTCATGGGTGGGCTACAAG

GAGCAGCAGCCATCGTGGCAGGCTTGTGANCTTTTNCCTGCTGACACCTGCTGCTTGACA

TGGGAGAAGTTCTGCACAGAAAGGCAGTGGGCATCCTTCATGAGGTGGGTACTTGGGGGN

CAGACACTGAGGAGCATTGT

BE539514

ACTCAAAAGAAGGCAGCAGACAAAGTCGTCTTCCTTCTTTCCAATGACGTCAACAGTGTG

TGCGATGGTACCTGTGGCAAGAGCGAGGGCAGTCCCAGTGAGAACTCTCAAGACCTCTTC

CCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAAGCCAGATTCATCTGCACAAATAC

GTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACGATTACAGTGCTCTCAGTGTCTGC

CCCAAGTACCACCTCATGAAGGATGCCACTGCTTTCTGTGCAGAACTTCTCCATGTCAAG

CAGCAGGTGTCAGCAGGAAAAAGATCACAAGCCTGCCACGATGGCCGCTGCTCCTTGTAG

CCCACCCATGAGAAGCAAGAGACCTTAAAGGCTTCCTATCCCACCAATTACAGGGAAAAA

ACGTGTGATGATCCTGAAGCTTACTATGCAGCCTACAAACAGCCTTAGTAATTAAAACAT

TTTATACCAATAAAATTTTCAAATATGcTAACTAATGTAGCATTAACTAACGATTGGAAA

CTACATTTACAACTTCAAAGCTGTTTTATACATAGAAATCAATTACAGCTTTAATTGAAA

ACTGTAACCATTTTGATAATGCAACAATAAAGCATCTTCAG

BX282554

GTCCAGTGCAGTGGCTTGCCACTCAAAAGAAGGCAGCAGACAAAGTCGTCTTCCTTCTTT

CCAATGACGTCAACAGTGTGTGCGATGGTACCTGTGGCAAGAGCGAGGGCAGTCCCAGTG

AGAACTCTCAAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAAGCC

AGATTCATCTGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACGATT

ACAGTGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCCACTGCTTTCTGTG

CAGAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGATCACAAGCCTGCCACG

ATGGCCGCTGCTCCTTGTAGCCCACCCATGAGAAGCAAGAGACCTTAAAGGCTTCCTATC

CCACCAATTACAGGGGAAAAAACGTGTGATGATCCTGAAGCTTACTAT

R74038

TATTGTTGCATTATCAAAATGGTTATAGTTTTCAATTAAAACTGTAATTGATTTCTATGT

ATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTAGTTAATGCTACATTAGTT

AGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTACTAAGGCTGTTTGTAGGC

TGCATAGTAAGCTTCAGGATCATCACACGTTTTTNCCCTGTAATTGGGTGGGGATAGGGA

AGCCTTTAAGGTCTCTTGCTTCTCATGGGGTGGGGCTACAAGGGAGGCAGGCAGCCATCG

TGGGCAGGGCTTGTGATCTTTTTCCCTGCTGACACCTGCTGCTTGACATGGGGGGAAGGT

TCTGGCACAGAAAGCAGTGGGCATCCTTCATGAGGGTGGTACTTGGGGGGCAGACACTGA

GGAGGCNTTGTAAATCGNCTTTTTNGTATCCAANCTCTNCTAAAGTAGGGNCCACCNCGT

TTTTTNTTGCAGGTGGATNCGGGGCTN

R74129

GGGTCCAGTGCAGTGGCTTGCNTNCAAAAGAAGGCAGCAGACAAAGTCGTCTTCCTTCTT

TCCAATGACGTCAACAGTGTGTGCGATGGTACCTGTGGCAAGAGCGAGGGCAGTCCCAGT

GAGAACTCTCAAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAAGC

CAGATTCATCTGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACGAT

TACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCCACTGCTTTCTGT

GCAGAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGATCACAAGCCTGCCAC

GATNGCTGCTGCTCCTTGTAGNCCACCCATGAGAAGCAAGTGACCTTTAAAGGNTTTCCT

ATTNCCACCNATTTACAGGG

BG433769

GACTAGATGTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAGTTTTCA

ATTAAAACTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCC

AATCGTTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGT

TTTAATTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTT

TCCCTGTAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTAC

AAGGAGCAGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTG

ACATGGAGAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAG

ACACTGAGAGCATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTAT

TTGTGCAGATGAATCTGGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAG

AGGTCTTGAGAGTTCTCACTGGGACTGCCCTCGCTCTTGCCACAGGTACCATCGCACACA

CTGTTGACGTCATTGGAAAAGAAGGAAGAC

BG530489

GAGTTCTCACTGGGACTGCCCTCGCTCTTGCCACAGGTACCATCGCACACACTGTTGACG

TCATTGGAAAGAAGGAAGACGACCTTGTCTGCTACCTTCTTTTGAGTGGCAAGCCACTGC

ACTGGACCCATCTCTGCTATTTTCTTTTTCTGCCACTTTTCAAGGATGACCTCACTTCTG

CAATGGTTTTGAAGAAATTCAGTGAAGTAACAAATTGTGTGATGGAAACATATTTCAGAT

GGGTAAACCACAAGAACCTTAATGGGGGGCAGTAGTGTGGTGGTAGAAAAGGAAGTCTTC

TTGATCCTTTCTGTGAGAGGAGAAAAGCATTTGTTATCTGTGAATAGCAAACAGCAGGCT

TTCACTCTGTAAACCATCCCTGACAAATGATCCCTTGCTAGAGAATGTCAGCTGAGCACC

AAGGGCCTTGTTAGTGACAGCAAGGAAAAACATCCTGATGTTCCTTTTGAACACATCACC

TGAAACACACTGATGCTTAAACCTTAACTTTTTTTTTTTGGGGGACATAGTCTCACTCTG

TCGCCCAGGCTGGAGTGCGTGGGAGAGGACCTCGGAAAGACTGGCAAGCATCCGCATACA

AGGGAGTAACAGCACAATACTCCGTGAACTTCGGAGCCCTCCAAAGGAATACTCAAGGGC

GGGTAAAGGATGGCAAGGGTCGACGGAGAGCCCACGAGGAGAGCGGAAGGTAGAGAGGAG

ACAAGCATAAGACGCGAGAGGAACTCCAAGGCGGGGCCAAAGAGAGAAACCACGGTCACC

AACAGAAG

AA007528

AGAAGCCAGATTCATCTGCACAAATACGTGGTGNTCTACTTTAGAGAGATTGATACAAAA

GACGATTACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCCACTGCT

TTCTGTGCAGAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGATCACAAGCC

TGCCACGATGGCTGCTGCTCCTTGTAGCCCACCCATGAGAAGCAAGAGACCTTAAAGGCT

TCCTATCCCACCAATTACAGGGNAAAAACNGTAGTGATNATCCCTGACAGCTTACTATGC

CAGCCNT

AA007529

TTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATCGGTTACAGTTTTCAATTAAAGCT

GTAATTNGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGTTTCCAATCGTTA

GTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATAAAATGTTTTAATTA

CTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTA

ATTGGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATTGGGTGGGCTACAAGGAG

CAGCAGCCATCCGTNGGCAAGGCTTTGTGGATNCT

BI260259

GGAAGAGAAAGATCGTCCAGAGGTTCCATCGCACACACTGTATGACGTCATTGGAAATGA

AGGAAGACGACTTTGTCTGCTGGCTTCTTGTGAGTGGCAAGCCACTGCAGTGGACCCATC

TCTGCTATTTTCTTTATTCTGCCACTTTTCAAGGATGACCTCACTTCTGCAATGGTTTTG

AAGAAAGTTCAGTGAAGTAACAAATTGTGTGATGGAAACATATTTCAGATGGGTAAACCA

CAAGAACCTTAATGGGGGGCAGTAGTGTGGTGGTAGAAAAGGAAGTCTTCTTGATCCTTT

CTGTGAGAGGAGAAAAGCATTAGTTATCTGTGAACAGCAAACAGCAGGCATTTCACATCT

GTAAACCATCCCTGACAAATGATCCCTTGCTAGAGAATGTCAGCTGAGCACCAAGGGGCC

TTGTTAGTGACAGCAAGGACAAAACATCCTGATGTTCCTTTTGAACACATCAGCTGAAAC

ACACTGATGCTCTAAACCGTTAACTATTTATTAATGGGGGAACATAGGTCTCAACTCATG

TACGACCAGGCTGGAGTGCAGTGGGGTTGAACATCGACAGACATAGCAAACCACCGATCA

CTAGGGAAACAACGCACAGAACTCCAGACTTAAAACACC

AA287951

ATTCGGCACCTGGGGGGCAGACACTGAGAGCATTGTAATCGTCTTTTGTATCAATCTCTC

TAAAGTAGACCACCACGTATTTGTGCAGATGAATCTGGCTTCTTAGATCACTGCAGAAAA

GGTTAAAGGCAAGGGGGAAGAGGTCTTGAGAGTTCTCACTGGGACTGCCCTCGCTCTTGC

CACAGGTACCATCGCACACACTGTTGACGTCATTGGAAAGAAGGAAGACGACTTTGTCTG

CTGCCTTCTTTTGAGTGGCAAGCCACTGCACTGGACCCATCTCTGCTATTTTCTTTTTCT

GCCACTTTTCAAGGATGACCTCACTTCTGCAATGGTTTTGAAGAAATTCAGTGAAGTAAC

AAATNTGTGTGATGGAAACATATTTCAGATGGGTAAACCACAAGAACCTTAATGGGGGGC

AGTAGTGTGGTGGTAGAAAAGGAAGTCTTCTTGATCCTTTCTGTGAGAGGAGAAAGC

AA287911

TTTTGATGGTCCACTTCCATTTAATGAATTAGTAAATATCTTTTCTCATGATTTTAATTA

CATTTTTTTCTCTAGCTTACTTTATTATAATACAGCACATAATACACCTAACATGCAAAA

TATGTGTTAATTGGCTGTTTATGTTATTGGTAAGACTTCCAGTCAACAGTAGGCTATTAG

AAGTTAAGTTGTGGGAAAATCAAAGGTTATAGGAGATTTTCAACTGCATGCAGGGCCGGT

GCCCTCCCCACTGTGTTGTTCAAGGGTCAGCTGTACTCTCTAAGGGCTTTGCTAACTTCA

AAACATGGAGTATTTGAATACAGAAACCAGAGCATTTACATACTCAGCTCAAGGCAGAGC

TATTAAAAAAACTCCTCTTCTCCATATGTAGGAAAGGAAATACAAATGCATCCTTTGAGT

CATTTGTGATGT

T97852

AACAGTTGTGCTCTGCCCACAAACAGGCGTCCCTTTCCCTCTGGATAACAACAAAAGCAA

GCCGGGANGNCTGNCGCTCTCCTCCTGCTGTCTCTGCTGGTGGCCACATGGGTGCTGGTN

GCAGGGATCTATCTAATGTNGAGGCACGAAAGGGATCAAGAGGACTTCCTTTTCTACCAC

CACACTACTGCCCCCCATTAAGGTTCTTGTNGGTTTACCCATCTGGAAATATGTTTCCAT

CACACAATTTGTTACTTCACTGGAATTTCTTCAAAACCATTGGCAGGANGTGAGGGTCAT

CCTTGGAAAAGTGGGC

T97745

CCTCACTTCTGCAATGGTTTTGAAGAAATTCAGTGAAGTAACAAATTGTGTGATGGAAAC

ATATTTCAGATGGGTAAACCACAAGAACCTTAATGGGGGGCAGTAGTGTGGTGGTAGAAA

AGGAAGTCTTCTTGATCCTTTCGTGCCTCCACATTAGATAGATCCCTGCCACCAGCACCC

ATGTGGCCACCAGCAGAGACAGCAGGAGGAGAGGCAGCCAGCCTCCCGGCTTTGCTTTTG

TTGTTATCCAGAGGGGAAAGGGGACGCCTGTTTNTGGGGCAGAGCACAACTGTTTCCCTC

GTGCCCGAATTCTTTGGGCCTTCGAGGGGCCAAATTTCCCTATTAGGTGAGGTCGTATTT

TAAATTTCGGTAATTCATGGTCATAGGCTTGTTTTTCCCCG

N40294

GTTTCAACACAATTTTGGATCAGCTGCCTGTTTGCAAAAACATAATATATTTCTGTTAAA

CAGTTCTTCACCTAACAGCATATTGCTCTTATAACTGGTAGAGCTGTTTCAAAGGAAGTT

GGTTTCTGGTCCAAGTTTTGACCTAAACCATGTCCATCTTCTATTACCAGCACTTACAAG

CACTGTGAAAACTGATCATGACAAATAAGTAAAATTTGCTACATTAAACATATTGCCTCA

GCCATTACTAAGCGTCCACTTGTAAAGCTGGACACAGTTTTTACTTTATGCTTCATTTTG

ATTTTTTATCCGTAAGACATAAATTAGAAGGCATGAGGTGGCCCTTTAAGGATAATCTGC

AAATATACACATTTTAAATAGTCATCCATCTGGAAATCGNTCCACCATTCCAGGGGAAGG

ATTCCAGGTATTGGTGCTGTGGTGGAAATAAAGCATTCCCCNGGGAAAAAAACCATTTTA

TGNCTAAATAATTACCACCATTAACCTCNTGGGGTT

AA809841

GAATACTAACTCTAAGAACCCCTCACTGATTCACTCAATAGCATCTTAAGTGAAAAACCT

TCTATTACATGCAAAAAATCATTGTTTTTAAGATAACAAAAGTAGGGAATAAACAAGCTG

AACCCACTTTTACTGGACCAAATGATCTATTATATGTGTAACCACTTGTATGATTTGGGA

TTTGCAT

AA832389

TTTTTTACAACTTCAAAGCTGTTTTATACATAGAAATCAATTACAGTTTTAATTGAAAAC

TATAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCAAACATCTAGTCTTCCATA

GACCATGCATTGCAGTGTACCCAGAACTGTTTAGCT

H14692

CTGAGTGTGATGGTGTAAGCCTGTGGTCCCAGCTACTAGGGAGGCTGAGATGGGATTACA

GGTGTGAGCCACGGCGCCTGGCCTAAAAGCATCTTTTTCTTTAACGCAGAGGTTATGTTG

TATTATTAGCATAAATGTTTTTTTCTGGGAATGCTTATTTCACACAGCACAATACTGAAT

CTTCTCTGGAATGTGGATCGATTTCAGATGGATGACTATTAAAATGTGTATATTTGCAGA

TTATCCTTAAAGGGCCACCTCATGCCTTCTAATTTATGTCTTACGGATAAAAAATCAAAA

TGAAGCATAAAGTAAAAACTGTGTCCAGCTTTACAAGTGGACGCTTAGTAATGGCTGAGG

CAATATGTTTAATGTAGCCAAATTTTACTTATTTGTCCATGATCCAGTTTTTCACAGTGC

TTGTTAAGTGCTGGTAATTAGGAAGGTGGGACATGGGTTAGGTCAAAACTTGGGACCNGA

AACCAACTTGN

AA732635

TTTTTTTTTTACAACTTCAAAGCTGTTTTATACATAGAAATCAATTACAGTTTTAATTGA

AAACTATAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCAAACATCTAGTCTTC

CATAGACCATGCATTGCATTGTACCCAGAACTGTTTAGCTAATATTCTATGTTTAATTAA

TGAATACTAACTCTAAGAACCCCTCACTGATTCACTCAATAGCATCTTAAGTGAAAAACC

TTCTATTACATGCAAAAAATCATTGGTTTT

AA928257

TTTTCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTCTTTACAAAGCAGGA

TACACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAGTGCCACAAGGATCT

GCTGAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAATGAATATTTCACTAT

ATTCTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGGTGTGGTCACATGGC

CAACATTTGGATAACAAATGAGGAATAATGGTACCGCCTCACTAGTGCCTGAGAACAGCA

TGTTCTGGAAAATGTCTCTGGAGTTAGAGATGTGTTAGCTTTTTCATTACAGATGGAGAA

ATACAATGTTTACACAACAGTCCAGGGGTGGGGTCAAAAGTTGGAAGGTGTCATTAGACG

CAGCCAAATAAAGTGAAGACAACCCAGGTGACTGGCAGCCCTGACTTGTGCGTGGGCG

AI184427

TTTCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTCTTTACAAAGCAGGAT

ACACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAGTGCCACAAGGATCTG

CTGAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAATGAATATTTCACTATA

TTCTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTGGTGGTGGTCACATGGCC

AACATTTGGATAACAAATGAGGA

AI298577

GAGATGGAGGTCTCGCTTTGTGACGTAGCCTGGTCTTGAGCGATCCTTTTGCCTTGGCCT

TGCCAAAGTGCTGGGATTGGAGGCATGAGCCACTGCACCCACCCCTGTTTTTTTTTTAAG

TAAACCATTATAATAACTCATTTATAAAAAGGTTACTTCAAGAGGGCTTTCAACTTAAGA

ATTATTTTCATTTTGAACATGAAAAGTTAAATAGTAACTAAGAAACTGAGAACTCTGACA

GTGACCTCTAATAGGTAACTTTAGGCAAAAGTAGACAAGTTTGTGGGTATTTTGTTGTTC

ATGTTAAAAGGCACCTGTACAAGAATCAAGATATGAATCTAGTTTGTAGAGGGAAGGTCT

TATGCAAATACCAAATCATACAAGTGGT

AI692717

AGAGATGTTGGTCTCGCTTTGTGACGTAGCCTGGGCTTGAGCGATCCTTTTGCCTTGGCC

TTGCCAAAGTGCTGGGATTGGAGGCATGAGCCACTGCACCCACCCCTGTTTTTTTTTTAA

GTAAACCATTATAATAACTCATTTATAAAAAGGTTACTTCAAGAGGGCTTTCAACTTAAG

AATTATTTTCATTTTGAACATGAAAAGTTAAATAGTAACTAAGAAACTGAGAACTCTGAC

AGTGACCTCTAATAGGTAACTTTAGGCAAAAGTAGACAAGTTTGTGGGTATTTTGTTGTT

CATGTTAAAAGGCACCTGTACAAGAATCAAGATATGAATCTAGTTTGTAGAGGGAAGGTC

TTATGCAAATACCAAATCATACAAGTGGTTACACATATAATAGATCATTTGGTCCAGTAA

AAGTGGGTTCAGCTTGTTTATTCCCTACTT

AA910922

GAGATGGAGGTCTCGCTTTGTGACGTAGCCTGGTCTTGAGCGATCCTTTTGCCTTGGCTT

GCAAAGTGCTGGGATTGGAGGCATGAGCACTGCACCCACCCCTGTTTTTTTTTTTAAGTA

AACCATTATAATAACTCATTTATAAAAAGGTTACTTCAAGAG

H90761

TTCACTCAATAGCATCTTAAGTGAAAAACCTTCTATTACATGCAAAAAATCATTGTTTTT

AAGATAACAAAAGTAGGGAATAAACAAGCTGAACCCACTTTTACTGGACCAAATGANCTA

TTATATGTATAACCACTTGTATGATTTGGTATTTGCATAAGACCTTCCCTCTACAAACTA

GATTCATATCTTGATTCTTGTACAGGTGCCTTTTTAATATTCTGTGATGAAATCGTTCAC

AGTCAGAGTACATGTCTGCTGCATATGGGAAATAGGGACTGTTGTTCTGAGGGACAAGGC

ACTCAATTCAGCCGTAAAGGCTGACCCGGGCTACTTTTTTTCCANGGGAATACAATTTTT

TTACCTTGGAATAAAATNGGGCCCGACNGGAC

AI620122

TTTTTTTTTTTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTCTTTACAAAG

CAGGATACACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAGTGCCACAAG

GATCTGCTGAAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAATGAATATTT

CACTATATTCTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGGTGTGGTCA

CATGGCCAACATTTGGATAACAAATGAGGAATAATGGTACCGCCTCACTAGTGCCTGAGA

ACAGCATGTTCTGGAAAATGTCTCTGGAGTTAGAGATGTGTTAGCTTTTTCATTACAGAT

GGAGAAATACAATGTTTACACAACAGTCCAGGGGTGGGGTCAAAAGTTGGAAGGTGTCAT

TAGACGCA

AI793318

AAATTTTTAACTTTTAATAGTTAAAATAGTTAACTATTGGTATGGTAGGAAATGATAAAG

TAGACTAGTATCTGTATACATTTTCTGCATTTATGACATACCTTTTTCTTCATTTTTTTC

AATATTTTAATTGAAAAGTTCATCCGAGTTTCATCTAAGTTTTTTCAAAGTGATACAAAT

CTCCAAAAAATTTTCCAATATATGTATTGAAAAAATCCAGGTGTAAGTGGCTCTGCGCAG

TCCAAACCTGTGTTGTTCAAGGGTCAACTGTGTATGAATCCAAGCGAAAGCTTTTCTTAA

CACCTCATAAGAACTATTTTTTAAAAAACAGGAACTAGCATAGAGTAACCATCACAGGTA

AAGTGTAATTTGTTATCAGCCATCTTTTGCCCATTTCAGTACTGGTAGAAGGCTCAATGG

TAAAAATAAA

AA962325

TTTTTTTTTTTTTTTTTTTTTTTTCTGACTGTCCCGTTTTTATTTTTACCATTGAGCCTT

CTACCAGTACTGAAATGGGCAAAAGATGGCTGATAACAAATTACACTTTACCTGTGATGG

TTACTCTATGCTAGTTCCTGTTTTTTAAAAAATAGTTCTTATGAGGTGTTAAGAAAAGCT

TTCGCTTGGATTCATACACAGTTGACCCTTGAACAACACAGGTTTGGACTGCGCAGACCA

CTTACACCTGGATTTTTTCAATACATATATTGGAAAATTTTTTGGGGATTTGTATCACTT

TGAAAAAACTTAGATGAAACTCGGATGGACTTTTCCATTAAAATATTGGAAAAAATGAAG

AAAAAGGT

AI733290

TTTTTTTTTTTTTTTTTTTTTTTTCTGACTGGCCCGTTTTTATTTTTACCATTGAGCCTT

CTACCAGTACTGAAATGGGCAAAAGATGGCTGATAACAAATTACACTTTACCTGGGATGG

TTACTCTATGCTAGTTCCTGTTTTTTAAAAAATAGTTCTTATGAGGGGTTAAAAAAAGCT

TTCGCTTGGATTCATACACAGTTGACCCTTGAACAACACAGGTTTGGACTGCGCAGAGCC

ACTTACACCTGGATTTTTTCAATACATATATTGGAAAATTTTTTGGAGATTTGTATCACT

TTGAAAAAACTTAGATGAAACTCGGATGAACTTTTCAATTAAAATATTGAAAAAAATGAA

GAAAAAGGTATGTCATAAATGCAGAAAATGTATACAGATACTAGTCTACTTTATCATTTC

CTACCATACCAATAG

BQ226353

TAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGTCCCTTTCCCTCTGGATAACAGTAA

GTGCCCAGTAACTTCAACCAGATGATCAAAGTGGCTCACACACAGTCACTGCCCCCCACT

CAGTATGTGGAAGGGTTGTGTGTATGTGGGCAGTGCAAGGGGTCGCTGCCTGTGTACACT

GAACTGGGGTGCAGAGAAAGCCAACAGTGCTGTCCCAGAGAACCTAGAATCTGAGTAAGA

ACAGGCTTTATTTGTAAAACCACTCGTGACTCTTTACAAAGCAGGATACACAGAAGGGAA

AAAAATACACAGTGCAAAATGGATGTTCTGAGTGCCACAAGGATCTGCTGAAAAAAGCCA

AAGATGTAAGATGGCTGGGTATATATGAGAATGAATATTTCACTATATTCTGATTCAATT

ACCAGTCTCAGTGGCCCAGGATGAGCTTTTGGTGTGGTCACATGGCCAACATTTGGATAA

CAAATGAGGAATAATGGTACCGCCTCACTAGTGCCTGAGAACAGCATGTTCTGGAAAATG

TCTCTGGAGTTAGAGATGTGTTAGCTTTTTCATTACAGATGGAGAAATACAATGTTTACA

CAACAGTCCAGGGGTGGGGGTCAAAAGTTGGAAGGTGTCATTAGACGCAGCCAAATAAAG

TGAAGACCACCCAGGTGACTGGCAGCCCTGACTTGTGCGTGGGCGAAACCTTACAGATTC

CTGGGGCACTCTGTGCCTGAACTTACCTGGATGGTCTTTGTGAGGCGGGTGGGCACTTAT

CCTCCATNAATGGTCAGTCTAACAAGACCGGCCTGTAAAAATGGCATCTAATAGGGGCTA

TGGAATGGAAAACAGTTGGTACCCAGAAATAACTTTAATT

W04890

GACAGTCTGGGAGCCCAGAGCTCTGGGAGGAGTNGGGAAAATGCTGCTTCCTGCTGCTTG

CTTCTAGGCACCTGCTTCCGCCATCTCACTTACCATGGCTAGAGATGGGGGTGAGACTGG

GGAAGGACAAAAGCAGGGAACAGATAAGGGATGGAAATCAGAAGGGAATATAGAAAGAAC

TCTGGATATGCNAGAAATGCCGGTACCTGAGCATTTTGTATCAATGGGAGTACCCTCTGT

AACTGCTCAGTAGGTTACAAATGAAGAGTCCACCAGTATTAGAAACAATTTAAACTTGCC

AGTACCAACTGGGATGTGTGCCTTCAATTTGAAAATTGTATGTTTTATTTTTTAAATTTG

GTTAACAGCATTAATTTATAGAGTATTTGATGTCATTTATGGTTCCCGAGGTGTTTCCAA

CACAATTTTTGGGATCA

BM455231

CTTTTAATAGTTAAAATAGTTAACTATTGGTATGGTAGGAAATGATAAAGTAGACTAGTA

TCTGTATACATTTTCTGCATTTATGACATACCTTTTTCTTCATTTTTTTCAATATTTTAA

TTGAAAAGTTCATCCGAGTTTCATCTAAGTTTTTTCAAAGTGATACAAATCTCCAAAAAA

TTTTCCAATATATGTATTGAAAAAATCCAGGTGTAAGTGGCTCTGCGCAGTCCAAACCTG

TGTTGTTCAAGGGTCAACTGTGTATGAATCCAAGCGAAAGCTTTTCTTAACACCTCATAA

GAACTATTTTTTAAAAAACAGGAACTAGCATAGAGTAACCATCACAGGTAAAGTGTAATT

TGTTATCAGCCATCTTTTGCCCATTTCAGTACTGGTAGAAGGCTCAATGGTAAAAATAAA

AACGGGACAGTCAGAAGATCTGGAAGTCCTGACCCTGCTTTCACCTGGCATGTGTAATCC

AGTCATGCTCGTATCAGTCTCTGTAGGAGCACTTGAAGGTATTACATAAATGCTATCTAA

CTCTGGGAAACGCCAACATGTGATTGCCTCCAGAGGAATCTTCTTTAAAAAAAAATTCAA

AATGTTATTTCCTTACTAGGATGTCTTTAAAGAATTATAACCCTTACCGTGCCTCCACAT

TAGATAGATCCCTGCCACCAGCACCCATGTGGCCACCAGCAGAGACAGCAGGAGGAGAGG

CAGCCAGCCTCCCGGCTTGCTTTTGTCTGGAAAAAAACAAAGCTTATTCACCTTTGGAAA

AAAATCCACACTTATCTCTTAATTTAAAAACTAAGACTTGGTATACTTTATAGAGGGTTA

TTTATTTTTTATTATTTTTTAGTTTTGAGACAGAGTCTCGCTTTGTTGCCTANGCTGGAG

TGCAGTGGCGCAATCTCGGTTCACTGCAGCCTCCGTTCTCCGGGGTTCAAGGCATGCTGG

CTCAGCCTCCTGTATAGCTGGGGATTAAAGGCATGTGTTCACGCGGCCCAGCCCCTTTTG

TAAAAGATTTAGATCCCTTTTAAAACCATCAGTCAGGAGGCTCCTTTAAAAAGTCTGGCC

ATCTAATCTTTTTTCCCCCAAAAGGGG

BI492426

TTTTTTTTTTTCTTTTTTCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTC

TTTACAAAGCAGGATACACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAG

TGCCACAAGGATCTGCTGAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAAT

GAATATTTCACTATATTCTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGG

TGTGGTCACATGGCCAACATTTGGATAACAAATGAGGAATAATCTCGTGC

BG674622

AATTTATAGAGTATTGATGTCATTTATGTTTCTGAGGTGTTTCAACACAATTTTGGATCA

GCTGCCTGTTTGCAAAAACATAATATATTTCTGTTAAACAGTTCTTCACCTAACAGCATA

TTGCTCTTATAACTGGTAGAGCTGTTTCAAAGGAAGTTGGTTTCTGGTCCAAGTTTTGAC

CTAAACCATGTCCATCTTCTATTACCAGCACTTACAAGCACTGTGAAAACTGATCATGAC

AAATAAGTAAAATTTGCTACATTAAACATATTGCCTCAGCCATTACTAAGCGTCCACTTG

TAAAGCTGGACACAGTTTTTACTTTATGCTTCATTTTGATTTTTTATCCGTAAGACATAA

ATTAGAAGGCATGAGGTGGCCCTTTAAGGATAATCTGCAAATATACACATTTTAATAGTC

ATCCATCTGAAATCGATCCACATTCCAGAGAAGATTCAGTATTGTGCTGTGTGAAATAAG

CATTCCCAGAAAAAAAACATTTATGCTAATAATACAACATAACCTCTGCATTAAAGAAAA

AGATGCTTTTAGGCCAGGCGCCGTGGCTCACGCCTGTAATCCCTGCACTTTGAGAGGCTG

AGGTGGGTGGATCATGAGGTCAGGAGATCAAGACCATCCTGGCTAACAGGGTGAAACCCC

GTCTCTACTGGGGATATAACAAAGTTAGCTGGGTGTGGTGGTGGGTGCTTGTGGTCCCAG

CTACTCAGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGAAGGCAGAGGTTGTAGTGAC

GCGAGGTTCACGCCACTGCATTCCAGTCTGGG

BX111256

CAGGAAGNTAAGAACAGTCCTAAAATCTCTTTGGCTTCTTTGTCCTGATATGCACCGGCA

TTTTCACAGTAGGAACTAGGGTTTCTGTCCAGTTTTTTTGGTTCTTTAAGGAATTAATGT

TATTCTGGGTACAACTGCTTACATACATAGCACATATAGATGACATTTTTACAGGCCGTC

TTGTTAGACTGACATACATGGAGGATAGTGCCACCCGCCTCACAAGAACATCAGGTAAGC

TCAGGCACAGAGTGCCCAGGAATCTGTAAGGCTTCGCCCACGCACAAGTCAGGGCTGCCA

GTCACCTGGGTTGTCTTCACTTTATTTGGCTGCGTCTAATGACACCTTCCAACTTTTGAC

CCCACCCCTGGACTGTTGTGTAAACATTGTATTTCTCCATCTGTAATGAAAAAGCTAACA

CATCTCTAACTCCAGAGACATTTTCCAGAACATGCTGTTCTCAGGCACTAGTGAGGCGGT

ACCATTATTCCTCATTTGTTATCCAAATGTTGGCCATGTGACCACACCAAAAGCTCATCC

TGGGCCACTGAGACTGGTAATTGAATCAGAATATAGTGAAATATTCATTCTCATATATAC

CCAGCCATCTTACATCTTTGGCTTTTTTCAGCAGATCCTTGTGGCACTCAGAACATCCAT

TTTGCACTGTGTATTTTTT

BX117618

AAATTTTTAACTTTTAATAGTTAAAATAGTTAACTATTGGTATGGTAGGAAATGATAAAG

TAGACTAGTATCTGTATACATTTTCTGCATTTATGACATACCTTTTTCTTCATTTTTTTC

AATATTTTAATTGAAAAGTTCATCCGAGTTTCATCTAAGTTTTTTCAAAGTGATACAAAT

CTCCAAAAAATTTTCCAATATATGTATTGAAAAAATCCAGGTGTAAGTGGCTCTGCGCAG

TCCAAACCTGTGTTGTTCAAGGGTCAACTGTGTATGAATCCAAGCGAAAGCTTTTCTTAA

CACCTCATAAGAACTATTTTTTAAAAAACAGGAACTAGCATAGAGTAACCATCACAGGTA

AAGTGTAATTTGTTATCAGCCATCTTTTGCCCATTTCAGTACTGGTAGAAGGCTCAATGG

TAAAAATAAAAACGGGACAGTCAGAAAAA

AA682806

TCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTCTTTACAAAGCAGGATAC

ACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAGTGCCACAAGGATCTGCT

GAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAATGAATATTTCACTATATT

CTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGGTGTGGTCACATGGCCAA

CATTTGGATAACAAATGAGGAATAATGGTACCGCCTCACTAGTGCCTGAGAACAGCATGT

TCTGGAAAATGTCTCTGGAGTTAGAGATGTGTTAGCTTTTTCATTACAGATGGAGAAATA

CAATGTTTACACAACAGTCCAGGGGTGGGGTCAAAG

AI202376

CTGACTGTCCCGTTTTTATTTTTACCATTGAGCCTTCTACCAGTACTGAAATGGGCAAAA

GATGGCTGATAACAAATTACACTTTACCTGTGATGGTTACTCTATGCTAGTTCCTGTTTT

TTAAAAAATAGTTCTTATGAGGTGTTAAGAAAAGCTTTCGCTTGGATTCATACACAGTTG

ACCCTTGAACAACACAGGTTTGGACTGCGCAGAGCCACCCTCGTGCCGAATT

AI658949

CTGACTGTCCCGTTTTTATTTTTACCATTGAGCCTTCTACCAGTACTGAAATGGGCAAAA

GATGGCTGATAACAAATTACACTTTACCTGTGATGGTTACTCTATGCTAGTTCCTGTTTT

TTAAAAAATAGTTCTTATGAGGTGTTAAGAAAAGCTTTCGCTTGGATTCATACACAGTTG

ACCCT

BG403405

GGAAATGATAAAGTAGACTAGTATCTGTATACATTTTCTGCATTTATGACATACCTTTTT

CTTCATTTTTTTCAATATTTTAATTGAAAAGTTCATCCGAGTTTCATCTAAGTTTTTTCA

AAGTGATACAAATCTCCAAAAAATTTTCCAATATATGTATTGAAAAAATCCAGGTGTAAG

TGGCTCTGCGCAGTCCAAACCTGTGTTGTTCAAGGGTCAACTGTGTATGAATCCAAGCGA

AAGCTTTTCTTAACACCTCATAAGAACTATTTTTTAAAAAACAGGAACTAGCATAGAGTA

ACCATCACAGGTAAAGTGTAATTTGTTATCAGCCATCTTTGCCCATTTCAGTACTGGTAG

AAGGCTCAATGGTAAAAATAAAAACGGGACAGTCAGAAGATCTGGAAGTCCTGACCCTGC

TTTCACCTGGCATGTGTAATCCAGTCATGCTCGTATCAGTCTCTGTAGGAGCACTTGAAG

GTATTACATAAATGCTATCTAACTCTGGGAAACGCCAACATGTGATTGCCTCCAGAGGAA

TCTTCTTTAAAAAAAAATTCAAAATGTTATTTCCTTACTAGGATGTCTTTAAAGAATTAT

AACCCTTACCGTGCCTCCACATTAGATAGATCCCTGCAACAGACCCATGTGGCACCAGCA

GAGACAGCAGGAGGAGAGGCAGCAGCTCCCGGTTGTTTGTCTGGAAAAACAAAGGTTATC

ACTTTG

BE673417

CTGACTGTCCCGTTTTTATTTTTACCATTGAGCCTTCTACCAGTACTGAAATGGGCAAAA

GATGGCTGATAACAAATTACACTTTACCTGTGATGGTTACTCTATGCTAGTTCCTGTTTT

TTAAAAAATAGTTCTTATGAGGTGTTAAGAAAAGCTTTCGCTTGGATTCATACACAGTTG

ACCCT

AW021469

GCACGAGATTATTCCTCATTTGTTATCCAAATGTTGGCCATGTGACCACACCAAAAGCTC

ATCCTGGGCCACTGAGACTGGTAATTGAATCAGAATATAGTGAAATATTCATTCTCATAT

ATACCCAGCCATCTTACATCTTTGGCTTTTTTCAGCAGATCCTTGTGGCACTCAGAACAT

CCATTTTGCACTGTGTATTTTTTTCCCTTCTGTGTATCCTGCTTTGTAAAGAGTCACGAG

TGGTTTTACAAATAAAGCCTGTTCTTACTCAGAAAAAAAAAAAAAAAAAAA

CF455736

NNTTGAACAGGCGTGACGGTCCGGATTCCCGGGATGTTGTGCTCTGCCCACAAACAGGCG

TCCCTTTCCCTCTGGATAACAACAAAAGCAAGCCGGGAGGCTGGCTGCCTCTCCTCCTGC

TGTCTCTGCTGGTGGCCACATGGGTGCTGGTGGCAGGGATCTATCTAATGTGGAGGCACG

AAAGGATCAAGAAGACTTCCTTTTCTACCACCACACTACTGCCCCCCATTAAGGTTCTTG

TGGTTTACCCATCTGAAATATGTTTCCATCACACAATTTGTTACTTCACTGAATTTCTTC

AAAACCATTGCAGAAGTGAGGTCATCCTTGAAAAGTGGCAGAAAAAGAAAATAGCAGAGA

TGGGTCCAGTGCAGTGGCTTGCCACTCAAAAGAAGGCAGCAGACAAAGTCGTCTTCCTTC

TTTCCAATGACGTCAACAGTGTGTGCGATGGTACCTGTGGCAAGAGCGAGGGCAGTCCCA

GTGAGAACTCTCAAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAA

GCCAGATTCATCTGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACG

ATTACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCCACTGCTTTCT

GTGCAGAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGATCACAAGCCTGCC

ACGATGGCTGCTGCTCCTTGTAGCCCACCCATGAGAAGCAAGAGACCTTNAAGGCTTCCT

ATCCCACCATTACAG

AW339874

TTTTTTTTTTTTTCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTCTTTAC

AAAGCAGGATACACAGAAGGGAAAAAAATACACAGGGCAAAATGGATGTTCTGAGTGCCA

CAAGGATCTGCTGAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAATGAATA

TTTCACTATATTCTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGGTGTGG

TCACATGGCCAACATTTGGATAACAAATGAGGAATAATGGTACCGCCTCACTAGTGCCTG

AGAACAGCATGTTCTGGAAAATGTCTCTGGAGTTAGAGATGTGTTAGCTTTTTCATTACA

GATGGAGAAATACAATGTTTACACAAC

BG399724

CATGATGTTCAGTATGATCAGTTAACCTTAACCTCTGAGCATCCTGAAGCAAAATCTAAA

TAATGCAGCTATTACCACTGGTGGTCCAGGCTCTGGTGAAGCCCTCTGAGCCCAGGAGGA

AGAGAAAGCATTGTCCAGAGGTAGGAACACAGTCTGGGAGCCCAGAGCTCTGGGAGGAGT

GGGAAAATGCTGCTTCCTGCTGCTTGCTTCTAGGCACCTGCTTCCGCCATCTCACTTACC

ATGGCTAGAGATGGGGGTGAGACTGGGGAAGGACAAAAGCAGGGAACAGATAAGGGATGG

AAATCAGAAGGGAATATAGAAAGAACTCTGGATGTGGAGAAATGCCGGTACCTGAGCATT

TTGTATCAATGGGAGTACCCTCTGTAACTGCTCAGTAGGTTACAAATGAAGAGTCCACCA

GTATTAGAAACAATTTAAACTTGCCAGTACCAACTGGGATGTGTGCCTTCAATTTGAAAA

TTGTATGTTTTATTTTTTAAATTTGTTAACAGCATTAATTTATAGAGTATTGATGTCATT

TATGTTTCTGAGGTGTTTCAA

BF475787

TCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTCTTTACAAAGCAGGATAC

ACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAGTGCCACAAGGATCTGCT

GAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAATGAATATTTCACTATATT

CTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGGTGTGGTCACATGGCCAA

CATTTGGATAACAAATGAGGAATAATGGTACCGCCTCACTAGTGCCTGAGAACAGCATGT

TCTGGAAAATGTCTCTGGAGTTAGAGATGTGTTAGCTTTTTCATTACAGATGGAGAAATA

CAATGTTTACACAACAGTCCAGGGGTGGGGTCAAAAGTTGGAAGGTGTCATTAGACGCAG

CCAAATAAAGTGAAGACAACCCAGGTGACTGGCAGCCCTGACTTGTGCGTGGGCGA

BF437145

CTGACTGTCCCGTTTTTATTTTTACCATTGAGCCTTCTACCAGTACTGAAATGGGCAAAA

GATGGCTGATAACAAATTACACTTTACCTGTGATGGTTACTCTATGCTAGTATCCTGTTT

TTTAAAAAATAGTTCTTATGAGGTGTTAAGAAAAGCTTTCGCTTGGATTCATACACAGTT

GACCCT

H64601

AGGAAGTTAAGAACAGTCCTAAAATCTCTTTGGCTTCTTTGTCCTGATATGCACCGGCAT

TTTCACAGTAGGAACTAGGGTTTCTGTCCAGTTTTTTTGGTTCTTTAAGGAATTAATGTT

ATTCTGGGTACAACTGCTTACATACATAGCACATATAGATGACATTTTTACAGGCCGTCT

TGTTAGACTGACATACATGGAGGATAGTGCCACCCGCCTCACAAGAACATCAGGTAAGCT

CAGGCACAGAGTCCNAGGGNATCTGTAAGGGCTTCGCCCACGCACAAGTCAGGGCTGCCA

GTCACCNGGGTTGTCTTCACTTTATTTGGGCTGCGTCTAATGACACCTTNCCAACTTTTT

GACCCCACCCTGGGGCTTGTTGTGTAAACCATTGTTATTTCTCCCNTCTGTAATGGAAAA

AGGTTAACACNTTTTTAACTTCCGGNGACATTTTTC

AF212365

gcacgagcga tgtcgctcgt gctgctaagc ctggccgcgc tgtgcaggag cgccgtaccc

cgagagccga ccgttcaatg tggctctgaa actgggccat ctccagagtg gatgctacaa

catgatctaa tccccggaga cttgagggac ctccgagtag aacctgttac aactagtgtt

gcaacagggg actattcaat tttgatgaat gtaagctggg tactccgggc agatgccagc

atccgcttgt tgaaggccac caagatttgt gtgacgggca aaagcaactt ccagtcctac

agctgtgtga ggtgcaatta cacagaggcc ttccagactc agaccagacc ctctggtggt

aaatggacat tttcctacat cggcttccct gtagagctga acacagtcta tttcattggg

gcccataata ttcctaatgc aaatatgaat gaagatggcc cttccatgtc tgtgaatttc

acctcaccag gctgcctaga ccacataatg aaatataaaa aaaagtgtgt caaggccgga

agcctgtggg atccgaacat cactgcttgt aagaagaatg aggagacagt agaagtgaac

ttcacaacca ctcccctggg aaacagatac atggctctta tccaacacag cactatcatc

gggttttctc aggtgtttga gccacaccag aagaaacaaa cgcgagcttc agtggtgatt

ccagtgactg gggatagtga aggtgctacg gtgcagctga ctccatattt tcctacttgt

ggcagcgact gcatccgaca taaaggaaca gttgtgctct gcccacaaac aggcgtccct

ttccctctgg ataacaacaa aagcaagccg ggaggctggc tgcctctcct cctgctgtct

ctgctggtgg ccacatgggt gctggtggca gggatctatc taatgtggag gcacgaaagg

atcaagaaga cttccttttc taccaccaca ctactgcccc ccattaaggt tcttgtggtt

tacccatctg aaatatgttt ccatcacaca atttgttact tcactgaatt tcttcaaaac

cattgcagaa gtgaggtcat ccttgaaaag tggcagaaaa agaaaatagc agagatgggt

ccagtgcagt ggcttgccac tcaaaagaag gcagcagaca aagtcgtctt ccttctttcc

aatgacgtca acagtgtgtg cgatggtacc tgtggcaaga gcgagggcag tcccagtgag

aactctcaag actcttcccc ttgcctttaa ccttttctgc agtgatctaa gaagccagat

tcatctgcac aaatacgtgg tggtctactt tagagagatt gatacaaaag acgattacaa

tgctctcagt gtctgcccca agtaccacct catgaaggat gccactgctt tctgtgcaga

acttctccat gtcaagtagc aggtgtcagc aggaaaaaga tcacaagcct gccacgatgg

ctgctgctcc ttgtagccca cccatgagaa gcaagagacc ttaaaggctt cctatcccac

caattacagg gaaaaaacgt gtgatgatcc tgaagcttac tatgcagcct acaaacagcc

ttagtaatta aaacatttta taccaataaa attttcaaat attgctaact aatgtagcat

taactaacga ttggaaacta catttacaac ttcaaagctg ttttatacat agaaatcaat

tacagtttta attgaaaact ataaccattt tgataatgca acaataaagc atcttcagcc

aaaaaaaaaa aaaaaa

AF208110

cggcgatgtc gctcgtgctg ataagcctgg ccgcgctgtg caggagcgcc gtaccccgag

agccgaccgt tcaatgtggc tctgaaactg ggccatctcc agagtggatg ctacaacatg

atctaatccc cggagacttg agggacctcc gagtagaacc tgttacaact agtgttgcaa

caggggacta ttcaattttg atgaatgtaa gctgggtact ccgggcagat gccagcatcc

gcttgttgaa ggccaccaag atttgtgtga cgggcaaaag caacttccag tcctacagct

gtgtgaggtg caattacaca gaggccttcc agactcagac cagaccctct ggtggtaaat

ggacattttc ctatatcggc ttccctgtag agctgaacac agtctatttc attggggccc

ataatattcc taatgcaaat atgaatgaag atggcccttc catgtctgtg aatttcacct

caccaggctg cctagaccac ataatgaaat ataaaaaaaa gtgtgtcaag gccggaagcc

tgtgggatcc gaacatcact gcttgtaaga agaatgagga gacagtagaa gtgaacttca

caaccactcc cctgggaaac agatacatgg ctcttatcca acacagcact atcatcgggt

tttctcaggt gtttgagcca caccagaaga aacaaacgcg agcttcagtg gtgattccag

tgactgggga tagtgaaggt gctacggtgc agctgactcc atattttcct acttgtggca

gcgactgcat ccgacataaa ggaacagttg tgctctgccc acaaacaggc gtccctttcc

ctctggataa caacaaaagc aagccgggag gctggctgcc tctcctcctg ctgtctctgc

tggtggccac atgggtgctg gtggcaggga tctatctaat gtggaggcac gaaaggatca

agaagacttc cttttctacc accacactac tgccccccat taaggttctt gtggtttacc

catctgaaat atgtttccat cacacaattt gttacttcac tgaatttctt caaaaccatt

gcagaagtga ggtcatcctt gaaaagtggc agaaaaagaa aatagcagag atgggtccag

tgcagtggct tgccactcaa aagaaggcag cagacaaagt cgtcttcctt ctttccaatg

acgtcaacag tgtgtgcgat ggtacctgtg gcaagagcga gggcagtccc agtgagaact

ctcaagacct cttccccctt gcctttaacc ttttctgcag tgatctaaga agccagattc

atctgcacaa atacgtggtg gtctacttta gagagattga tacaaaagac gattacaatg

ctctcagtgt ctgccccaag taccacttca tgaaggatgc cactgctttc tgtgcagaac

ttctccatgt caagcagcag gtgtcagcag gaaaaagatc acaagcctgc cacgatggct

gctgctcctt gtagcccacc catgagaagc aagagacctt aaaggcttcc tatcccacca

attacaggga aaaaacgtgt gatgatcctg aagcttacta tgcagcctac aaacagcctt

agtaattaaa acattttata ccaataaaat tttcaaatat tactaactaa tgtagcatta

actaacgatt ggaaactaca tttacaactt caaagctgtt ttatacatag aaatcaatta

cagctttaat tgaaaactgt aaccattttg ataatgcaac aataaagcat cttccaaaaa

aaaaaaaaaa aaaaaaaaaa aaaaaaaa

AF208111

cggcgatgtc gctcgtgctg ataagcctgg ccgcgctgtg caggagcgcc gtaccccgag

agccgaccgt tcaatgtggc tctgaaactg ggccatctcc agagtggatg ctacaacatg

atctaatccc cggagacttg agggacctcc gagtagaacc tgttacaact agtgttgcaa

caggggacta ttcaattttg atgaatgtaa gctgggtact ccgggcagat gccagcatcc

gcttgttgaa ggccaccaag atttgtgtga cgggcaaaag caacttccag tcctacagct

gtgtgaggtg caattacaca gaggccttcc agactcagac cagaccctct ggtggtaaat

ggacattttc ctatatcggc ttccctgtag agctgaacac agtctatttc attggggccc

ataatattcc taatgcaaat atgaatgaag atggcccttc catgtctgtg aatttcacct

caccaggctg cctagaccac ataatgaaat ataaaaaaaa gtgtgtcaag gccggaagcc

tgtgggatcc gaacatcact gcttgtaaga agaatgagga gacagtagaa gtgaacttca

caaccactcc cctgggaaac agatacatgg ctcttatcca acacagcact atcatcgggt

tttctcaggt gtttgagcca caccagaaga aacaaacgcg agcttcagtg gtgattccag

tgactgggga tagtgaaggt gctacggtgc aggtaaagtt cagtgagctg ctctggggag

ggaagggaca tagaagactg ttccatcatt cattgctttt aaggatgagt tctctcttgt

caaatgcact tctgccagca gacaccagtt aagtggcgtt catgggggtt ctttcgctgc

agcctccacc gtgctgaggt caggaggccg acgtggcagt tgtggtccct tttgcttgta

ttaatggctg ctgaccttcc aaagcacttt ttattttcat tttctgtcac agacactcag

ggatagcagt accattttac ttccgcaagc ctttaactgc aagatgaagc tgcaaagggt

ttgaaatggg aaggtttgag ttccaggcag cgtatgaact ctggagaggg gctgccagtc

ctctctgggc cgcagcggac ccagctggaa cacaggaagt tggagcagta ggtgctcctt

cacctctcag tatgtctctt tcaactctag tttttgaagt ggggacacag gaagtccagt

ggggacacag ccactcccca aagaataagg aacttccatg cttcattccc tggcataaaa

agtgntcaaa cacaccagag ggggcaggca ccagccaggg tatgatgggt actacccttt

tctggagaac catagacttc ccttactaca gggacttgca tgtcctaaag cactggctga

aggaagccaa gaggatcact gctgctcctt ttttgtagag gaaatgtttg tgtacgtggt

aagatatgac ctagcccttt taggtaagcg aactggtatg ttagtaacgt gtacaaagtt

taggttcaga ccccgggagt cttgggcatg tgggtctcgg gtcactggtt ttgactttag

ggctttgtta cagatgtgtg accaagggga aaatgtgcat gacaacacta gaggtagggg

cgaagccaga aagaagggaa gttttggctg aagtaggagt cttggtgaga ttttgctgtg

atgcatggtg tgaactttct gagcctcttg tttttcctca gctgactcca tattttccta

cttgtggcag cgactgcatc cgacataaag gaacagttgt gctctgccca caaacaggcg

tccctttccc tctggataac aacaaaagca agccgggagg ctggctgcct ctcctcctgc

tgtctctgct ggtggccaca tgggtgctgg tggcagggat ctatctaatg tggaggcacg

aaaggatcaa gaagacttcc ttttctacca ccacactact gccccccatt aaggttcttg

tggtttaccc atctgaaata tgtttccatc acacaatttg ttacttcact gaatttcttc

aaaaccattg cagaagtgag gtcatccttg aaaagtggca gaaaaagaaa atagcagaga

tgggtccagt gcagtggctt gccactcaaa agaaggcagc agacaaagtc gtcttccttc

tttccaatga cgtcaacagt gtgtgcgatg gtacctgtgg caagagcgag ggcagtccca

gtgagaactc tcaagacctc ttcccccttg cctttaacct tttctgcagt gatctaagaa

gccagattca tctgcacaaa tacgtggtgg tctactttag agagattgat acaaaagacg

attacaatgc tctcagtgtc tgccccaagt accacttcat gaaggatgcc actgctttct

gtgcagaact tctccatgtc aagcagcagg tgtcagcagg aaaaagatca caagcctgcc

acgatggctg ctgctccttg tagcccaccc atgagaagca agagacctta aaggcttcct

atcccaccaa ttacagggaa aaaacgtgtg atgatcctga agcttactat gcagcctaca

aacagcctta gtaattaaaa cattttatac caataaaatt ttcaaatatt actaactaat

gtagcattaa ctaacgattg gaaactacat ttacaacttc aaagctgttt tatacataga

aatcaattac agctttaatt gaaaactgta accattttga taatgcaaca ataaagcatc

ttccaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

AF250309

atgtcgctcg tgctgctaag cctggccgcg ctgtgcagga gcgccgtacc ccgagagccg

accgttcaat gtggctctga aactgggcca tctccagagt ggatgctaca acatgatcta

atcccgggag acttgaggga cctccgagta gaacctgtta caactagtgt tgcaacaggg

gactattcaa ttttgatgaa tgtaagctgg gtactccggg cagatgccag catccgcttg

ttgaaggcca ccaagatttg tgtgacgggc aaaagcaact tccagtccta cagctgtgtg

aggtgcaatt acacagaggc cttccagact cagaccagac cctctggtgg taaatggaca

ttttcctata tcggcttccc tgtagagctg aacacagtct atttcattgg ggcccataat

attcctaatg caaatatgaa tgaagatggc ccttccatgt ctgtgaattt cacctcacca

ggctgcctag accacataat gaaatataaa aaaaagtgtg tcaaggccgg aagcctgtgg

gatccgaaca tcactgcttg taagaagaat gaggagacag tagaagtgaa cttcacaacc

actcccctgg gaaacagata catggctctt atccaacaca gcactatcat cgggttttct

caggtgtttg agccacacca gaagaaacaa acgcgagctt cagtggtgat tccagtgact

ggggatagtg aaggtgctac ggtgcagctg actccatatt ttcctacttg tggcagcgac

tgcatccgac ataaaggaac agttgtgctc tgcccacaaa caggcgtccc tttccctctg

gataacaaca aaagcaagcc gggaggctgg ctgcctctcc tcctgctgtc tctgctggtg

gccacatggg tgctggtggc agggatctat ctaatgtgga ggcacgaaag gatcaagaag

acttcctttt ctaccaccac actactgccc cccattaagg ttcttgtggt ttacccatct

gaaatatgtt tccatcacac aatttgttac ttcactgaat ttcttcaaaa ccattgcaga

agtgaggtca tccttgaaaa gtggcagaaa aagaaaatag cagagatggg tccagtgcag

tggcttgcca ctcaaaagaa ggcagcagac aaagtcgtct tccttctttc caatgacgtc

aacagtgtgt gcgatggtac ctgtggcaag agcgagggca gtcccagtga gaactctcaa

gacctcttcc cccttgcctt taaccttttc tgcagtgatc taagaagcca gattcatctg

cacaaatacg tggtggtcta ctttagagag attgatacaa aagacgatta caatgctctc

agtgtctgcc ccaagtacca cctcatgaag gatgccactg ctttctgtgc agaacttctc

catgtcaagc agcaggtgtc agcaggaaaa agatcacaag cctgccacga tggctgctgc

tccttgtagc ccacccatga gaagcaagag accttaaagg gttccttttc ccatcattta

caggggaaaa acgtgtgatg atc

AK095091

catattagag tctacagata tgcctttctt acagcaatcc tgcacccaca taaaagctac

attttcaata caagattaaa aggtattctg caaaatgtgc aaggttttca tgtctgctgg

tgtagctgta gtgatggctt catgaatttt tttctttttt gactatggtc cttacgctgg

attcatttat cttgaaatgg tgaacaatca cagctgcaga ccctcaattt atggtacata

tcaagcaatt tggctttttt tcttgtaatg aaaaaaaaaa gttttttttg ctttttttca

tgacactgct tcttgggagc actgccagca ttactagtgg cacttcgtat gggtcctaag

gtgttattga aggtttacga tattgcacta aacacgaaaa ataccagaga accactggag

atacttttta ctgtgatatg taatttactg gagacaggaa ctgctcgttt ggagatggtt

agcatcacag ggtgttttaa gtcgatactt gcaacccttg agctcaccac agtagcaaca

ggaggtggct aggaaattat tcacagcagg acagtacgca ctgcaattaa ttgtatgcag

ttatgattta ataccacatc tttatgctca cgtttctctc aactgtgaat ggtgccatgt

acagttggta tgtgtgtgtt taagttttga taaattttta acttttaata gttaaaatag

ttaactattg gtatggtagg aaatgataaa gtagactagt atctgtatac attttctgca

tttatgacat acctttttct tcattttttt caatatttta attgaaaagt tcatccgagt

ttcatctaag ttttttcaaa gtgatacaaa tctccaaaaa attttccaat atatgtattg

aaaaaatcca ggtgtaagtg gctctgcgca gtccaaacct gtgttgttca agggtcaact

gtgtatgaat ccaagcgaaa gcttttctta acacctcata agaactattt tttaaaaaac

aggaactagc atagagtaac catcacaggt aaagtgtaat ttgttatcag ccatcttttg

cccatttcag tactggtaga aggctcaatg gtaaaaataa aaacgggaca gtcagaagat

ctggaagtcc tgaccctgct ttcacctggc atgtgtaatc cagtcatgct cgtatcagtc

tctgtaggag cacttgaagg tattacataa atgctatcta actctgggaa acgccaacat

gtgattgcct ccagaggaat cttctttaaa aaaaaattca aaatgttatt tccttactag

gatgtcttta aagaattata acccttaccg tgcctccaca ttagatagat ccctgccacc

agcacccatg tggccaccag cagagacagc aggaggagag gcagccagcc tcccggcttg

cttttgtctg gaaaaaacaa agcttattca cctttggaaa acaaatccac acttatctct

taatttaaaa actaagactt ggtatacttt atagaggttt atttattttt tattattttt

tagttttgag acagagtctc gctttgttgc ctaggctgga gtgcagtggc gcaatctcgg

ttcactgcag cctccgtctc ccgggttcaa gcaatgctgc ctcagcctcc tgagtagctg

ggattacagg catgtgtcac cgcgcccagc cactttgtag agatttagat ccctttaaaa

ccatcagtca gaagctcttt agatagtctg ccaatcatat ctttttccct agagtgtgca

ggtcttgcat tagattctca aaagggatat gggacccagg aagttaagaa cagtcctaaa

atctctttgg cttctttgtc ctgatatgca ccggcatttt cacagtagga actagggttt

ctgtccagtt tttttggttc tttaaggaat taatgttatt ctgggtacaa ctgcttacat

acatagcaca tatagatgac atttttacag gccgtcttgt tagactgaca tacatggagg

atagtgccac ccgcctcaca agaacatcag gtaagctcag gcacagagtg cccaggaatc

tgtaaggctt cgcccacgca caagtcaggg ctgccagtca cctgggttgt cttcacttta

tttggctgcg tctaatgaca ccttccaact tttgacccca cccctggact gttgtgtaaa

cattgtattt ctccatctgt aatgaaaaag ctaacacatc tctaactcca gagacatttt

ccagaacatg ctgttctcag gcactagtga ggcggtacca ttattcctca tttgttatcc

aaatgttggc catgtgacca caccaaaagc tcatcctggg ccactgagac tagtaattga

atcagaatat agtgaaatat tcattctcat atatacccag ccatcttaca tctttggctt

ttttcagcag atccttgtgg cactcagaac atccattttg cactgtgtat ttttttccct

tctgtgtatc ctgctttgta aagagtcacg agtggtttta caaataaagc ctgttcttac

tcag

BM983744

TTTTTTTTTTTTTTTTCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTCTT

TACAAAGCAGGATACACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAGTG

CCACAAGGATCTGCTGAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAATGA

ATATTTCACTATATTCTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGGTG

TGGTCACATGGCCAACATTTGGATAACAAATGAGGAATAATGGTACCGCCTCACTAGTGC

CTGAGAACAGCATGTTCTGGAAAATGTCTCTGGAGTTAGAGATGTGTTAGCTTTTTCATT

ACAGATGGAGAAATACAATGTTTACACAACAGTCCAGGGGTGGGGTCAAAAGTTGGAAGG

TGTCATTAGACGCAGCCAAATAAAGTGAAGACAACCCAGGTGACTGGCAGCCCTGACTTG

TGCGTGGGCGAAGCCTTACAGATTCCTGGGCACTCTGTGCCTGAGCTTACCTGATGTTCT

TGTGAGGCGGGTGGCACTATCCTCCATGTATGTCAGTCTAACAAGACGGCCTGTAAAAAT

GTCATCTATATGTGCTATGTATGTAAGCAGTTGTACCCAGAATAACATTAATCCTCGTGC

CGAAT

CB305764

TTTTTTTTTTTTTTTGTTGGGCTGAAGATGCTTTATTATTGCATTATCAAAATGGTTATA

GTTTTCAATTAAAACTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGT

AGTTTCCAATCGTTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTAT

AAAATGTTTTAATTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACA

CGTTTTTTCCCTGTAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGT

GGGCTACAAGGAGCAGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTG

CTGCTTGACATGGAGAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTT

GGGGCAGACACTGAGAGCATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCAC

CACGTATTTGTGCAGATGAATCTGGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAG

GGGGAAGAGGTCTTGAGAGTTCTCACTGGGACTGCCCTCGCTCTTGCCACAGGTACCATC

GCACACACTGTTNACGTCATTGGAAAGAAGGAAGACGACTTTGTCTGCTGCCTTCTTTTG

AGTG

BM715988

TGGTTTTTGTTTTTTTTTCATTTTCTGTTGGATTACAGAAAAAGAATGGGACCCATTCAG

GTCTCGATTTCCAAAGGTAAAGATGGAAGGCTGGGCAGACTGGCTTTTGTTACCTGACAT

GCCGTAGGGTGAGCTTAGAGGAAGAAAGAAAACAATTTTTATTTGGCCAAAACAGAACAA

ATGCTGAAAAGGAAATCTTGTTTTTTTCCTAAAGCCAAATAGAAATGATTTGGGTATAAT

TTAAGAGTCCTTGTGTTGTACAGATATGGTGACTGATGTAGTTATTAATACTACCAACTT

AGTCATCAAGCCTCAATTTTCCTTTACCTGAAGGATTAAGTGAAAGCTTTTGGAGTTCAT

GATGTTCAGTATGATCAGTTAACCTTAACCTCTGAGCATCCTGAAGCAAAATCTAAATAA

TGCAGCTATTACCACTGGTGGTCCAGGCTCTGGTGAAGCCCTCTGAGCCCAGGAGGAAGA

GAAAGCATTGTCCAGAGGTAGGAACACAGTCTGGGAGCCCAGAGCTCTGGGAGGAGTGGG

AAAATGCTGCTTCCTGCTGCTTGCTTCTAGGCACCTGCTTCCGCCATCTCACTTACCATG

GCTAGAGATGGGGGTGAGACTGGGGAAGGACACAAGCAGGGAACAGATAAGGGATGGAAA

TCAGAAGGGAATATAGAAAGAACTCTGGATGTGGAGACATGCCGGTACCTGAGCATTTTG

TATCAATGGGAGTACCTCT

BM670929

TTTTTTTTTTTTTTTTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAG

TTTTCAATTAAAGCTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTA

GTTTCCAATCGTTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATA

AAATGTTTTAATTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACAC

GTTTTTTTCCCTGTAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGT

GGGCTACAAGGAGCAGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTG

CTGCTTGACATGGAGAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTT

GGGGCAGACACTGAGAGCATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCAC

CACGTATTTGTGCAGATGAATCTGGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAG

GGGGAAGAGGTCTTGAGAGTTCTCACTGGGACTTGCCTCGCTCTTGCCACAGGTACCATC

GCACACACTGTTGACGTCATTGGAAAGAAAGAAGACGACTTTGTCTGCTGCCTTCTT

BI792416

GCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAGTTTTCAATTAAAGCTGTAA

TTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTAGT

BI715216

CACGCGTCCGATTTTATACCAATAAAATTTTCAAATATTGCTAACTAATGTAGCATTAAC

TAACGATTGGAAACTACATTTACAACTTCAAAGCTGTTTTATACATAGAAATCAATTACA

GCTTTAATTGAAAACTGTAACCATTTTGATAATGCAACAATAAAGCATCTTCAGCCAAAA

AAAAAAA

N56060

AGAAAAAGAAAATAGCAGAGATGGGTCCAGTGCAGTGGCTTGCATAAAAAAGAAGGCAGC

AGACAAAGTCGTCTTCCTTCTTTCCAATGACGTCAACAGTGTGTGCGATGGTACCTGTGG

CAAGAGCGAGGGCAGTCCCAGTGAGAACTCTCAAGACCTCTTCCCCCCTTGCCTTTAACC

TTTTCTGCAGTGATCTAAGAAGCCAGATTCATCTGCACAAATACGTGGTGGTCTACTTTA

GAGAGATTGATACAAAAGACGATTACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCA

TGAAGGATGCCACTGCTTTCTGTGCAGAACTTCTCCATGTCAAGCAGCAGGTTTCAGCAG

G

CB241389

TTTTTTTTTTTTTTGTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTACAG

TTTTCAATTAAAGCTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTA

GTTTCCAATCGTTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATA

AAATGTTTTAATTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACAC

GTTTTTTCCCTGTAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTG

GGCTACAAGGAGCAGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGC

TGCTTGACATGGAGAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTG

GGGCAGACACTGAGAGCATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACC

ACGTATTTGTGCAGATGAATCTGGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGG

GGGAAGAGGTCTTGAGAGTTCTCACTGGGACTGCCCTCGCTCTTGCCACAGGTACCATCG

CACACACTGTTGACGTCATTGGAAAGAAGGAAGACGACTTTGTCTGCTGCCTTCTTTTGA

GTGGCAAGCCACTGCACTGGACCCATCTCTGCTATTTTCTTTTTCTNGCACTTTTCAAGG

ATGACTCACTTCTGCAATGGTTTTTGAGAATTCAGTGAAGTACAAATGTGTGATGGAACA

TAT

AV660618

CGCTCGTGCTGCTAAGCCTGGCCGCGCTGTGCAGGAGCGCCGTACCCCGAGAGCCGACCG

TTCAATGTGGCTCTGAAACTGGGCCATCTCCAGAGTGGATGCTACAACATGATCTAATCC

CCGGAGACTTGAGGGACCTCCGAGTAGAACCTGTTACAACTAGTGTTGCAACAGGGGACT

ATTCAATTTTGATGAATGTAAGCTGGGTACTCCGGGCAGATGCCACACCAGAAGAAACAA

ACGCGAGCTTCAGTGGTGATTCCAGTGACTGGGGATAGTGAAGGTGCTACGGTGCAGCTG

ACTCCATATTTTCCTACTTGTGGCAGCGACTGCATCCGACATAAAGGAACAGTTGTGCTC

TGCCCACAAACAGGCGTCCCTTTCCCTCTGGATAACAAC

BX088671

GCTGAGTGTGATGGTGTAAGCCTGTGGTCCCAGCTACTAGGGAGGCTGAGATGGGATTAC

AGGTGTGAGCCACGGCGCCTGGCCTAAAAGCATCTTTTTCTTTAACGCAGAGGTTATGTT

GTATTATTAGCATAAATGTTTTTTTCTGGGAATGCTTATTTCACACAGCACAATACTGAA

TCTTCTCTGGAATGTGGATCGATTTCAGATGGATGACTATTAAAATGTGTATATTTGCAG

ATTATCCTTAAAGGGCCACCTCATGCCTTCTAATTTATGTCTTACGGATAAAAAATCAAA

ATGAAGCATAAAGTAAAAACTGTGTCCAGCTTTACAAGTGGACGCTTAGTAATGGCTGAG

GCAATATGTTTAATGTAGCAAATTTTACTTATTTGTCATGATCAGTTTTCACAGTGCTTG

TAAGTGCTGGTAATAGAAGATGGACATGGTTTAGGTCAAAACTTGGACCAGAAACCAACT

TCCTTTGAAACAGCTCTACCAGNTATAAGAGCAATATG

CB154426

CTGTTGACGTCATTGGAAAGAAGGAAGACGACTTTGTCTGCTGCCTTCTTTTGAGTGGCA

AGCCACTGCACTGGACCCATCTCTGCTATTTTCTTTTTCTGCCACTTTTCAAGGATGACC

TCACTTCTGCAATGGTTTTGAAGAAATTCAGTGAAGTAACAAATTGTGTGATGGAAACAT

ATTTCAGATGGGTAAACCACAAGAACCTTAATGGGGGGCAGTAGTGTGGTGGTAGAAAAG

GAAGTCTTCTTGATCCTTTCTGTGAGAGGAGAAAAGCATTTGTTATCTGTGAACAGCAAA

CAGCAGGCTTTCACTCTGTAAACCATCCCTGACAAATGATCCCTTGCTAGAGAATGTCAG

CTGAGCACCAAGGGCCTTGTTAGTGACAGCAAGGAAAAACATCCTGATGTTCCTTTTGAA

CACATCACCTGAAACACACTGATGCTTAAACCTTAACTTTTTTTTTTTTGGAGACACAGT

CTCACTCTGT

CA434589

TTTTTTTTTTTTTTTTTTCTGAGTAAGAACAGGCTTTATTTGTAAAACCACTCGTGACTC

TTTACAAAGCAGGATACACAGAAGGGAAAAAAATACACAGTGCAAAATGGATGTTCTGAG

TGCCACAAGGATCTGCTGAAAAAAGCCAAAGATGTAAGATGGCTGGGTATATATGAGAAT

GAATATTTCACTATATTCTGATTCAATTACCAGTCTCAGTGGCCCAGGATGAGCTTTTGG

TGTGGTCACATGGCCAACATTTGGATAACAAATGAGGAATAATGGTACCGCCTCACTAGT

GCCTGAGAACAGCATGTTCTGGAAAATGTCTCTGGAGTTAGAGATGTGTTAGCTTTTTCA

TTACAGATGGAGAAATACAATGTTTACACAACAGTCCAGGGGTGGGGTCAAAAGTTGGAA

G

CA412162

TTTTTTTTTTTTTTTTTTGGCTGAAGATGCTTTATTGTTGCATTATCAAAATGGTTATAG

TTTTCAATTAAAACTGTAATTGATTTCTATGTATAAAACAGCTTTGAAGTTGTAAATGTA

GTTTCCAATCGTTAGTTAATGCTACATTAGTTAGCAATATTTGAAAATTTTATTGGTATA

AAATGTTTTAATTACTAAGGCTGTTTGTAGGCTGCATAGTAAGCTTCAGGATCATCACAC

GTTTTTTCCCTGTAATTGGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTG

GGCTACAAGGAGCAGCAGCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGC

TGCTTGACATGGAGAAGTTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACGTG

GGGCAGACACTGAGAGCATTGTAATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACC

ACGTATTTGTGCAGATGAATCTGGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGG

GGGAAGA

CA314073

TTTTTTTTTTTTTTTTTTGAAAGGGTCAGGACTTCCAGATCTTCTGACTGTCCCGTTTTT

ATTTTTACCATTGAGCCTTCTACCAGTACTGAAATGGGCAAAAGATGGCTGATAACAAAT

TACACTTTACCTGTGATGGTTACTCTATGCTAGTTCCTGTTTTTTAAAAAATAGTTCTTA

TGAGGTGTTAAGAAAAGCTTTCGCTTGGATTCATACACAGTTGACCCTTGAACAACACAG

GTTTGGACTGCGCAGAGCCACTTACACCTGGATTTTTTCAATACATATATTGGAAAATTT

TTTGGAGATTTGTATCACTTTGAAAAAACTTAGATGAAACTCGGATGAACTTTTCAATTA

AAATATTGAAAAAAATGAAGAAAAAGGTATGTCATAAATGCAGAAAATGTATACAGATAC

TAGTCTACTTTATCATTTCCTACCATACCAATAGTTAACTATTTTAACTATTAAAAGTTA

AAAATTTATCAAAACTTAAACACACACATACCAACTGTACATGGCACCATTCACAGTTGA

GAGAAACGTGAGCATAAAGATGTGGTATTAAATCATAACTGCATACAATTAATTGCAGTG

CGTACTGTCCTGCTGTGAATATTTCCTAGCCCTCGTGCCGAATC

BF921554

GTGGGTGACCGTGGCTTGCCACTCAAAAGAAGGCAGCAGACAAAGTCGTCTTCCTTCTTT

CCAATGACGTCAACAGTGTGTGCGATGGTACCTGTGGCAAGAGCGAGGGCAGTCCCAGTG

AGAACTCTCAAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAAGCC

AGATTCATCTGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACGATT

ACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCCACTGCTTTCTGTG

CATAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGATCACAAGCCTGCCACG

ATGGCTGCTGCTCCTTGTAGCCCACCCATGAGAAGCAAGAGACCTTAAAGGCTTCCTATC

CCACCAATTACAGGGAAAAAAACGTGTGATGATCCTGAAGCCACGGTCAA

BF920093

TAGAGGATCCCGGTCGACGGTGGTTCAGTGATCATCACACTTTTTCCCTGTAATAGGTGG

GATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCAGCCAT

CGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAGTTATG

CACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGCATTGT

AATCGTCTTTTGTATCAATCTCTCTAAAGTAGACCACCACGTATTTGTGCAGATGAATCT

GGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAGAGTTCT

CACTGGGACTGCCCTCGCTCTTGCCACAGGTACCATCGCACACACTGTTGACGTCATTGG

AAAGAAGGAAGACGACTTTGTCTGCTGCCTTCTTTTGAGTGGCAAGCCACGGTCAACCCA

CAAGCCACGGTCAACCCAC

AV685699

TCTACGTGGTAAGATATGACCTAGCCCTTTTAGGTAAGCGAACTGGTATGTTAGTAACGT

GTACAAAGTTTAGGTTCAGACCCCGGGAGTCTTGGGCATGTGGGTCTCGGGTCACTGGTT

TTGACTTTAGGGCTTTGTTACAGATGTGTGACCAAGGGGAAAATGTGCATGACAACACTA

GAGGTAGGGGCGAAGCCAGAAAGAAGGGAAGTTTTGGCTGAAGTAGGAGTCTTGCGACTG

CATCCGACATAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGTCCCTTTCCCTCTGGA

TAACAACAAAAGCAAGCCGGGAGGCTGGCTGCCTCTCCTCCTGCTGTCTCTGCTGGTGGC

CACATGGGTGCTGGTGGCAGGGATCTATCTAATGTGGAGGCACGAAAGGATCAAGAAGAC

TTCCTTTTCTACCACCACACTACTGCCCCCCATTAAGGTTCTTGTGGTTTACCCATCTGA

AATATGTTTCCATCACACAATTTGTTACTTCACTGAATTTCTTCAAAACCATTGCAGAAG

TGAGGTCATCCTTGAAAGTGGCAGAGTAGCAGAGATGGGTCCAGTGCAGTGGCTTGCCAC

TCGTGCGATGGTCTT

AV650175

GGCACGAGCACTGGCTGAAGGAAGCCAAGAGGATCACTGCTGCTCCTTTNTTCTAGAGGA

AATGTTTGTCTACGTGGTAAGATATGACCTAGCCCTTTTAGGTAAGCGAACTGGTATGTT

AGTAACGTGTACAAAGTTTAGGTTCAGACCCCGGGAGTCTTGGGCATGTGGGTCTCGGGT

CACTGGTTTTGACTTTAGGGCTNTGTTACAGATGTGTGACCAAGGGGAAAATGTGCATGA

CAACACTAGAGCTGACTCCATATTTTCCTACTTGTGGCAGCGACTGCATCCGACATAAAG

GAACAGTTGTGCTCTGCCCACANACAGGCGTCCCTTTCCCTCTGGATAACAACATAAGCA

AGCCGGGAGGCTGGCTGCCTCTCCTCCTGCTGTCTCTGCTGGTGGCACATGGGTGCTGGT

GGAGGGATCTATCTAATGTGGAGGCACGGATCAAGAAGACTTNCTTNTCTACCACCACAC

TACTGGCCCCAATAAGGGTCTNGTGGNTACCCCATCTGAATATGTTCATACACAATTTGT

ACTCACTGAATTCTCAAAACATTGAGAGTGAGGCATCCTGAAAGTGCGAAAAGANATGCN

AATGGTCAGTGCATGCTGCACTAGCAGCATGGACTT

BX483104

GATCCCGCGCAGTGGCCCGGCGATGTCGCTCGTGCTGCTAAGCCTGGCCGCGCTGTGCAG

GAGCGCCGTACCCCGAGAGCCGACCGTTCAATGTGGCTCTGAAACTGGGCCATCTCCAGA

GTGGATGCTACAACATGATCTAATCCCCGGAGACTTGAGGGACCTCCGAGTAGAACCTGT

TACAACTAGTGTTGCAACAGGGGACTATTCAATTTTGATGAATGTAAGCTGGGTACTCCG

GGCAGATGCCAGCATCCGCTTGTTGAAGGCCACCAAGATTTGTGTGACGGGCAAAAGCAA

CTTCCAGTCCTACAGCTGTGTGAGGTGCAATTACACAGAGGCCTTCCAGACTCAGACCAG

ACCCTCTGGTGGTAAATGGACATTTTCCTACATCGGCTTCCCTGTAGAGCTGAACACAGT

CTATTTCATTGGGGCCCATAATATTCCTAATGCAAATATGAATGAAGATGGCCCTTCCAT

GTCTGTGAATTTCACCTCACCAGGCTGCCTAGACCACATAATGAAATATAAAAAAAAGTG

TGTCAAGGCCGGAAGCCTGTGGGATCCGAACATCACTGCTTGTAAGAAGAATGAGGAGAC

AGTAGAAGTGAACTTCACAACCACTCCCCTGGGAAACAGATACATGGCTCTTATCCAACA

CAGCACTATCATTCGG

CD675121

GTCTTGCATTAGATTCTCAAAAGGGATATGGGACCCAGGAAGTTAAGAACAGTCCTAAAA

TCTCTTTGGCTTCTTTGTCCTGATATGCACCGGCATTTTCACAGTAGGAACTAGGGTTTC

TGTCCAGTTTTTTTGGTTCTTTAAGGAATTAATGTTATTCTGGGTACAACTGCTTACATA

CATAGCACATATAGATGACATTTTTACAGGCCGTCTTGTTAGACTGACATACATGGAGGA

TAGTGCCACCCGCCTCACAAGAACATCAGGTAAGCTCAGGCACAGAGTGCCCAGGAATCT

GTAAGGCTTCGCCCACGCACAAGTCAGGGCTGCCAGTCACCTGGGTTGTCTTCACTTTAT

TTGGCTGCGTCTAATGACACCTTCCAACTTTTGACCCCACCCCTGGACTGTTGTGTAAAC

ATTGTATTTCTCCATCTGTAATGAAAAAGCTAACACATCTCTAACTCCAGAGACATTTTC

CAGAACATGCTGTTCTCAGGCACTAGTGAGGCGGTACCATTATTCCTCATTTGTTATCCA

AATGTTGGCCATGTGACCACACCAAAAGCTCATCCTGGGCCACTGAGACTGGTAATTGAA

TCAGAATATAGTGAAATATTCATTCTCATATATACCCAGCCATCTTACATCTTTGGCTTT

TTTCAGCAGATCCTTGTGGCACTCAGAACATCCATTTTGCACTGTGTATTTTTTTCCCTT

CT

BE081436

TGTGTAACTCTCAAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAA

GCCAGATTCATCTGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACG

ATTACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGGAGGATGCCACTGCTTTCT

GTGCAGAACTTCTCCATGTCAAGTAGCAGGTGTCAGCAGGAAAAAGATCACAAGCCTGCC

ACGATGGCTGCTGCTCCTTGTAGCCCACCCATGAGAAGCAAGAGACCTTAAAGGCTTCCT

ATCCCACCAATTACAGGGAAAAAACGTGTGATGAT

AW970151

CTGAAATATGTTTCCATCACACAATTTGTTACTTCACTGAATTTCTTCAAAACCATTGCA

GAAGTGAGGTCATCCTTGAAAAGTGGCAGAAAAAGAAAATAGCAGAGATGGGTCCAGTGC

AGTGGCTTGCCACTCAAAAGAAGGCAGCAGACAAAGTCGTCTTCCTTCTTTCCAATGACG

TCAACAGTGTGTGCGATGGTACCTGTGGCAAGAGCGAGGGCAGTCCCAGTGAGAACTCTC

AAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGTGATCTAAGAAGCCAGATTCATC

TGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGATACAAAAGACGATTACAATGCTC

TCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCCACTGCTTTCTGTGCAGAACTTC

TCCATGTCAAGTAGCAGGTGTCAGCAGGAAAAAGATCACAAGCCTGCCACGATGGCTGCT

GCTCCTTGTAGCCCACCCATGAGAAGCAAGAGACCTTAAAGGCTTCCTATCCCACCAATT

ACAGGGAAAAAAACGTGTGATGATCCCTGAAGCTTACTATGCAGCCTACANACAGCCTTA

GTAATAAAACATTTTATCCAATAAAATTTCAAATTTTGCTTAACTATGTGCATAAACTAC

GATTGAAAACTCTTTACACT

AW837146

CATTGTGGTTGCAGCTGCATAGTAAGCTTCAGGATCATCACACGTTTTTTCCCTGTAATT

GGTGGGATAGGAAGCCTTTAAGGTCTCTTGCTTCTCATGGGTGGGCTACAAGGAGCAGCA

GCCATCGTGGCAGGCTTGTGATCTTTTTCCTGCTGACACCTGCTGCTTGACATGGAGAAG

TTCTGCACAGAAAGCAGTGGCATCCTTCATGAGGTGGTACTTGGGGCAGACACTGAGAGC

ATTGTAATCGTCTTTTGTATCAATCTCCCTAAAGTAGACCACCACGTATTTGTGCAGATG

AATCTGGCTTCTTAGATCACTGCAGAAAAGGTTAAAGGCAAGGGGGAAGAGGTCTTGAGA

GTTCTCACTGGGACTGCCCTCGCTCTTGCCACAGGTACCATCGCACACACTGTTGACGTC

ATTGGAAAGAAGGAAGACGACTTTGTCTGCTGCCTTCTTTTGAGTGGCAAGCCACTGCAC

TGGACCCATCT

AW368264

GTGAATAAGCTTTGTTTTTTCCAGACAAAAGCAAGCCAGGAGGCTGGCTGCCTCTCCTCC

TGCTGTCTCTGCTGGTGGCCACATGGTTGCTGGTGGCAGGGATCTATCTAATGTGGAGGC

ACGGTAAGGGTTATAATTCTTTAAAGTCATCCTAGTAAGGAAATAACATTTGGAATTTTT

TTTTAAAGAAGATTCCTCTGGAGGCAATCACCTGTTGGCGTTTCCCAGAGTTAGATAGCA

TTTATGTAATACCTTCAAGTGCTCCTACAGAGACTGATACGAGCATGACTGGATTACACA

TGCCAGGTGAAAGCAGGGCCAGGACTTCCAGATCTTCTGACTGTCCCGTTTTTATTTTTA

CCATTGAGCCTTCTACCAGAACTGAAATGGGCAAAAGATGGCTGATAACAAATTACACTT

TACCTGTGATGGTTACTCTATGCTAGTTCCTGTTTTTAAAAAAATAGTTCTTATGAGGTG

TCAAGAAAAGCTTTCGCTTGGATTCATACACAGTTGACCCTTGAACAACACAG

D25960

GATCCTGAAGCTTACTATGCAGCCTACAAACAGCCTTAGTAATTAAAACATTTTATACCA

ATAAAATTTTCAAATATTGCTAACTAATGTAGCATTAACTAACGATTGGAAACTACATNN

ACAACTTCAAAGCTGTTTTATACATAGAAATCAATTACAGCTTTAATTGAAAACTATAAC

CATTTTGATAATGCAACANTAAAGCATCTTCAGCCAAA

AV709899

GCAACTTCCAGTCCTACAGCTGTGTGAGGTGCAATTACACAGAGGCCTTCCAGACTCAGA

CCAGACCCTCTGGTGGTAAATGGACATTTTCCTATATCGGCTTCCCTGTAGAGCTGAACA

CAGTCTATTTCATTGGGGCCCATAATATTCCTAATGCAAATATGAATGAAGATGGCCCTT

CCATGTCTGTGAATTTCACCTCACCAGGCTGCCTAGACCACATAATGAAATATAAAAAAA

AGTGTGTCAAGGCCGGAAGCCTGTGGGATCCGAACATCACTGCTTGTAAGAAGAATGAGG

AGACAGTAGAAGTGAACTTCACAACCACTCCCCTGGGAAACAGATACATGGCTCTTATCC

AACACAGCACTATCATCGGGTTTTCTCAGGTGTTTGAGCCACACCAGAAGAAACAAACGC

GAGCTTCAGTGGTGATTCCAGTGACTGGGGATAGTGAAGGTGCTACGGTGCAGCTGACTC

CATATTTTCCTACTTGTGGCAGCGACTGCATCCGACATAAAGGAACAGTTGTGCTCTGCC

CACAAACAGGCGTNCCTTTTCCTCTGGATAACAACAAAAGCAAGCCGGGAGGCTTGGCTG

CTCTCCTTCTGCTGGCCTTTGCTGTGGCCACATTGGTGCTGGTGGCAGGGATCTATCTAA

TGTGGATGCACGTCTCGTGGTTTACCCATCTGAAATATGTTCN

BX431018

ATTTTTCCTCTTGTGGCAGCGACTGGCATCCGACATAAAGGAACAGTTGTGCTCTGCCCA

CAAACAGGCGTCCCTTTCCCTCTGGATAACAACAAAAGCAAGCCGGGAGGCTGGCTGCCT

CTCCTCCTGCTGTCTCTGCTGGTGGCCACATGGGTGCTGGTGGCAGGGATCTATCTAATG

TGGAGGCACGAAAGGATCAAGAAGACTTCCTTTTCTACCACCACACTACTGCCCCCCATT

AAGGTTCTTGTGGTTTACCCATCTGAAATATGTTTCCATCACACAATTTGTTACTTCACT

GAATTTCTTCAAAACCATTGCAGAAGTGAGGTCATCCTTGAAAAGTGGCAGAAAAAGAAA

ATAGCAGAGATGGGTCCAGTGCAGTGGCTTGCCACTCAAAAGAAGGCAGCAGACAAAGTC

GTCTTCCTTCTTTCCAATGACGTCAACAGTGTGTGCGATGGTACCTGTGGCAAGAGCGAG

GGCAGTCCCAGTGAGAACTCTCAAGACCTCTTCCCCCTTGCCTTTAACCTTTTCTGCAGT

GATCTAAGAAGCCAGATTCATCTGCACAAATACGTGGTGGTCTACTTTAGAGAGATTGAT

ACAAAAGACGATTACAATGCTCTCAGTGTCTGCCCCAAGTACCACCTCATGAAGGATGCC

ACTGCTTTCTGTGCAGAACTTCTCCATGTCAAGCAGCAGGTGTCAGCAGGAAAAAGATCA

CAAGCCTGCCACGATGGCTGCT6CTCCTTGTAGCCCACCCATGAGAAGCAAGAGACCTTA

AGGCTTCTATCCCACCANTACAGGNAAAAACGTGTGATGATCCTGAAGCTTACTATGCAG

CCTACAACAGGCTTAGTATTAAAACATTTATACCCATAAATTTTCAAATTGCT

AL535617

TAGGTGACACTATAGAACAAGTTTGTACAAAAAAGCAGGCTGGTACCGGTCCGGAATTCC

CGGGATAGTGGMCCGGCGAKGTCGCTCGTGCTGCTAAGCCTGGCCGCGCTGTGCAGGAGC

GCCGTACCCCGAGAGCCGACCGTTCAATGTGGCTCTGAAACTGGGCCATCTCCARAGTGG

ATGSKACAACATGATCTAATCCCGGGAGACTTGAGGGACCTCCGAGTAGAACCTGTTACA

ACTAGTGTTGCAACAGGGGACTATTCAATTTTGATGAATGTAAGCTGGGTACTCCGGGSA

GATGCCAGCATCCGCTTGTTGAAGGCCACCAAGATTTGTGTGAMGGGCAAAAGCAACWTC

CAGTCCTACAGCWGTGTGAGGTAGCAATTACACAGAGAGCACATATCCAGACTCTAGACC

AGACCCTCTGGWGGTAAATGGACATTTTCCTATATCGGCTTCCCTGTAGAGCTGAACACA

GTCTATATTCATTGGGGCCCAWAATAWWCCTAATGCAAATATGAATGAAGATGGCCCTTC

CATGTCTGTGAATTTCACCTCACCAGGCTGCCTAGACCACATAATGAAATAWAAAAAAAA

GTGTGTCAAGGCCGGAAGCCTGTGGGATCCGAACATCACTGCTTGTAAGAAGAATGARGA

GACAGTAGAAGTGAACTTCACAACCACTCCCCTGGGAAACAGATAMATKGCTCTTATCCA

ACACARMACTATCATCGGGTTTTCTCAGGTGTTTGAGCCACACCAGAAGAAACAAACGCG

AGCTTCAGTGGTGATTCCAGTGACTGGGGATAGTGAAGGTGCTACGGTGCAGCTGACTCC

ATATTTTCCTACTTGTGGCAGCGWCTGCATCCGACATAAAGGAACAGTTGTGCTCTGCCC

ACAAACAGGCGTCCCTTTYCCTCTGGATAACAACAAAAGCAACYGGGAGSTGGYTGYCT

AL525465

WAATWAKADDRATANHTGAAAACTATAACCATTTNTGATAATNGNAANAATAAAGCATCT

TCAGCCAAACATCTAGTCTTCCATAGACCATGCATTGCAGTGTACCCAGAWCTGTTTAGC

TAATATTCTATGTTTAATTAATGAATACTAACTCTAAGAACCCCTCACTGATTCACTCAA

TAGCATCTTAAGTGAAAAACCTTCTATTACATGCAAAAAATCATTGTTTTTAAGATAACA

AAAGTAGGGAATAAACAAGCTGAACCCACTTTTACTGGACCAAATGATCTATTATATGTG

TAACCACTTGTATGATTTGGTATTTGCATAAGACCTTCCCTCTACAAACTAGATTCATAT

CTTGATTCTTGTACAGGTGCCTTTTAACATGAACAACAAAATACCCACAAACTTGTCTAC

TTTTGCCTAAAGTTACCTATTAGAGGTCACTGTSAGAGTKCTCAGTTTCTTAGTTACTAT

TTAASTTTTSATGTTCAAAATGAAAATAATTCTKAAGTKGAAAGSGCTCTTGAAGTAACC

TTTTTATAAATGAGTTATTATAATGGTTTACTTAAATAAAAVAGAGGGGKTTTTGCGGTG

GCTCATGCCTCCAATCCCAGCACTTTGGCAAGGCCAAGGCAAAAVGATCGCTCAAGACCA

GGCTACGTCACAAAGCGAGACCTCCATCTCTACAAAAGATTTAAAAAATTAGCTGAGTGT

GATGGTGTGAGCCTGTGGTCCCAGCTACTAGGGAGGCTGAGATGGGAGGATCACTTGAGC

CCTGGAGGTCAAGGGTGCAGTAAACGGTGATTGTGCCACTGCACTCCATCCTGGGTGAGA

GCAGACCCTGTCTAAAACAAACAAACGAAAAAACCCCCACAGAATGACAGAACATAAAAG

ATGCACATTTTGTCTTCCAACTTTTTACTCTTCTAAAAGCATCTTTTTTAAATTTTTTAA

ATTTTTTTTTTTTTGAGACAGAGTTTCACTCTGTCACACAGGCTGGAGTGMGTGGCGTGA

CTCGGCTCACTAMAACTCTGCYTCCGGGGTYACSCATCTCCTGCWCAGCTCCTGAGAAGC

KGGAYAMAGGMCCACACAAACCAGTAAYTTTATWTTTTGAAAAAGGGTTYACCTGTASMA

GRAGGCTGAATCCGACMAARTMACCMCCACYYCAAADGAGGAWAAGKGKRSMGGSCBGGC

A

BX453536

TTATGGGGGGCAGTAGTGTGGTGGTAGAAAAGGAAGTCTTCTTGATCCTTTCGTGCCTCC

CATTAGATAGATCCCTGCCACCAGCACCCATGTGGCCACCAGCAGAGACAGCAGGAGGAG

AGGCAGCCAGCCTCCCGGCTTGCTTTTGTTGTTATCCAGAGGGAAAGGGACGCCTGTTTG

TGGGCAGAGCACAACTGTTCCTTTATGTCGGATGCAGTCGCTGCCACAAGTAGGAAAATA

TGGAGTCAGCTGCACCGTAGCACCTTCACTATCCCCAGTCACTGGAATCACCACTGAAGC

TCGCGTTTGTTTCTTCTGGTGTGGCTCAAACACCTGAGAAAACCCGATGATAGTGCTGTG

TTGGATAAGAGCCATGTATCTGTTTCCCAGGGGAGTGGTTGTGAAGTTCACTTCTACTGT

CTCCTCATTCTTCTTACAAGCAGTGATGTTCGGATCCCACAGGCTTCCGGCCTTGACACA

CTNTNTTTTATATTTCATTATGTGGTCTAGGCAGCCTGGTGAGGTGAAATTCACAGACAT

GGAAGGGCCATCTTCATTCATATTTGCATTAGGAATATTATGGGCCCCAATGAAATAGAC

TGTGTTCAGCTCTACAGGGGAAGCCGATATAGGAAAATGTCCATTTACCACCAGAGGGTC

TGGTCTGAGTCTTGAAGGCCTTTTGTGTTATTGCACCTTACACAGCTGTTAGACTGGGAA

GTTGCTTTTGCCCCGCACACAAATCTTGTGGGCCTTCAACAGCGGATGCTGCCATTTGCC

CCGAAGTCCCCAGCTCAATTCATTAAAAATTGAATAGGCCCCTTGTGGCAACCCTAGTTG

GTACAGGGTTTTACTTGGGGGGCCCCTCTAAGTTTCCCCGGGATATAAACAAAGTGTGG

BX453537

TTATGGGGGGCAGTAGTGTGGTGGTAGAAAAGGAAGTCTTCTTGATCCTTTCGTGCCTCC

ACATTAGATAGATCCCTGCCACCAGCACCCATGTGGCCACCAGCAGAGACAGCAGGAGGA

GAGGCAGCCAGCCTCCCGGCTTGCTTTTGTTGTTATCCAGAGGGAAAGGGACGCCTGTTT

GTGGGCAGAGCACAACTGTTCCTTTATGTCGGATGCAGTCGCTGCCACAAGTAGGAAAAT

ATGGAGTCAGCTGCACCGTAGCACCTTCACTATCCCCAGTCACTGGAATCACCACTGAAG

CTCGCGTTTGTTTCTTCTGGTGTGGCTCAAACACCTGAGAAAACCCGATGATAGTGCTGT

GTTGGATAAGAGCCATGTATCTGTTTCCCAGGGGAGTGGTTGTGAAGTTCACTTCTACTG

TCTCCTCATTCTTCTTACAAGCAGTGATGTTCGGATCCCACAGGCTTCCGGCCTTGACAC

ACTTTTTTTTATATTTCATTATGTGGTCTAGGCAGCCTGGTGAGGTGAAATTCACAGACA

TGGAAGGGCCATCTTCATTCATATTTGCATTAGGAATATTATGGGCCCCAATGAAATAGA

CTGTGTTCAGCTCTACAGGGAAGCCGATATAGGAAAATGTCCATTTACCACCAGAGGGTC

TGGTCTGAGTCTGGAAGGCCTCTGTGTAATTGCACCTCACACAGCTGTAGGACTGGGAGT

TGCTTTTGCCCGTACACAAATCTTGTTGGCCTTCAACAAGCGGATGCTGGCATCTGGCGG

GGGTACCCAGCTTACATTCATCAAAATTGAATAGTCCCCTTGTTGCAACACTAGTTTGTA

AACAGGTTCTACTCCGGGGGTCCCCTCAGTCTCCCGG

AV728945

CAAATATGAATGAAGATGGCCCTTCCATGTCTGTGAATTTCACCTCACCAGGCTGCCTAG

ACCACATAATGAAATATAAAAAAAAGTGTGTCAAGGCCGGAAGCCTGTGGGATCCGAACA

TCACTGCTTGTAAGAAGAATGAGGAGACAGTAGAAGTGAACTTCACAACCACTCCCCTGG

GAAACAGATACATGGCTCTTATCCAACACAGCACTATCATCGGGTTTTCTCAGGTGTTTG

AGCCACACCAGAAGAAACAAACGCGAGCTTCAGTGGTGATTCCAGTGACTGGGGATAGTG

AAGGTGCTACGGTGCAACTGACTCCATATTTTCCTACTTGTGGCAGCGACTGCATCCGAC

ATAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGTCCCTTTCCCTCTGGATAACAAC

AV728939

GCAAATATGAATGAAGATGGCCCTTCCATGTCTGTGAATTTCACCTCACCAGGCTGCCTA

GACCACATAATGAAATATAAAAAAAAGTGTGTCAAGGCCGGAAGCCTGTGGGATCCGAAC

ATCACTGCTTGTAAGAAGAATGAGGAGACAGTAGAAGTGAACTTCACAACCACTCCCCTG

GGAAACAGATACATGGCTCTTATCCAACACAGCACTATCATCGGGTTTTCTCAGGTGTTT

GAGCCACACCAGAAGAAACAAACGCGAGCTTCAGTGGTGATTCCAGTGACTGGGGATAGT

GAAGGTGCTACGGTGCAGCTGACTCCATATTTTCCTACTTGTGGCAGCGACTGCATCCGA

CATAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGTCCCTTTCCCTCTGGATAACAAC

AV727345

GCAAATATGAATGAAGATGGCCCTTCCATGTCTGTGAATTTCACCTCACCAGGCTGCCTA

GACCACATAATGAAATATAAAAAAAAGTGTGTCAAGGCCGGAAGCCTGTGGGATCCGAAC

ATCACTGCTTGTAAGAAGAATGAGGAGACAGTAGAAGTGAACTTCACAACCACTCCCCTG

GGAAACAGATACATGGCTCTTATCCAACACAGCACTATCATCGGGTTTTCTCAGGTGTTT

GAGCCACACCAGAAGAAACAAACGCGAGCTTCAGTGGTGATTCCAGTGACTGGGGATAGT

GAAGGTGCTACGGTGCAGCTGACTCCATATTTTCCTACTTGTGGCAGCGACTGCATCCGA

CATAAAGGAACAGTTGTGCTCTGCCCACAAACAGGCGTCCCTTTCCCTCTGGATAACAAC

AAAAGCAAGCCGGGAGGCTGGCTGCCTCTCCTCCTGCTGTCTCTGCTGGTGGCCACATGG

GTGCTGGTGGCAGGGATCTATCTAATGTGGAGGCACGAAAGGATCAAGAAGACTTCCTTT

TTTACCACCACACTACTGTCTCCCATTAAAGATCTTGTGGTTTATCCATCTGAAATATTG

TTCCATTACACATATTGGTACCTAACTGAAATTCTTTAAAACCATTGCAAATTGAGGTCA

CTCTTGAAAGGGCGTG

Sequencesi dentified as those of CACNA1D cluster

BM128550

CGGCTCCTACCTTTTGCCCGATCCCCTTCCCCATTCCGCCCCCGCCCCAACGCAGTGCAC

AGTGCCCTGCACACAGTAGTCGCTCAATAAATGTTCGTGGATGATGATGATGATGATGAT

GAAAAAAATGCAGCATCAACGGCAGCAGCAAGCGGACCACGCGAACGAGGCAAACTATGC

AAGAGGCACCAGACTTCCTCTTTCTGGTGAAGGACCAACTTCTCAGCTGAATAGCTCCAA

GCAAACTGTCCTGTCTTGGCAAGCTGCAATCGATGCTGCTAGACAGGCCAAGGCTGCCCA

AACTATGAGCACCTCTGCACCCCCACCTGTAGGATCTCTCTCCCAAAGAAAACGTCAGCA

ATACGCCAAGAGCAAAAAACAGGGTAACTCGTCCAACAGCCGACCTGCCCGCGCCCTTTT

CTGTTTATCACTCAATAACCCCATCCGAAGAGCCTGCATTAGTATAGTGGAATGGAAACA

TTTGACATATTTATATTATTGGCTATTTTTTGCCAAT

BI755471

GAATATGACCCTGAGGCAAAGGGAAGGATAAACACCTTGATGTGGTCACTCTGCTTCGAC

GCATCCAGCCTCCCCTGGGGTTTGGGAAGTTATGTCCACACAGGGTAGCGTGCAAGAGAT

TAGTTGCCATGAACATGCCTCTCAACAGTGACGGGACAGTCATGTTTAATGCAACCCTGT

TTGCTTTGGTTCGAACGGCTCTTAAGATCAAGACCGAAGGGAACCTGGAGCAAGCTAATG

AAGAACTTCGGGCTGTGATAAAGAAAATTTGGAAGAAAACCAGCATGAAATTACTTGACC

AAGTTGTCCCTCCAGCTGGTGATGATGAGGTAACCGTGGGGAAGTTCTATGCCACTTTCC

TGATACAGGACTACTTTAGGAAATTCAAGAAACGGAAAGAACAAGGACTGGTGGGAAAGT

ACCCTGCGAAGAACACCACAATTGCCCTACAGGCGGGATTAAGGACACTGCATGACATTG

GGCCAGAAATCCGGCGTGCTATATCGTGTGATTTGCAAGATGACGAGCCTGAGGAAACAA

AACGAGAAGAAGAAGATGATGTGTTCAAAAGAAATGGTGCCCTGCTTGGAAACCATGTCA

ATCATGTTAATAGTGATAGGAGAGATTCCCTTCAGCAGACCAATAGCACCACCGTCCCCT

GCATTGTCCAAAGGCCTTCAATTCCACCTGCAAGTGATACTGAGAAACCGCTGTTTCCTC

CAGCAGGAAATTCGGGGTGTCATAACCATCATAACCATTAATTCCATAGGAAAGCAAGGT

TCCCACTTCAACAATGCCAGTCTCGAATAGTGCCAATATGTCCAAAGCTTGCCATGGTAA

GCGGGCCAGCATTGGGAACC

BQ549084

GCACGAGATTAATTAGACTTTTGTATAAGAGATGTCATGCCTCAAGAAAGCCATAAACCT

GGTAGGAACAGGTCCCAAGCGGTTGAGCCTGGCAGAGTACCATGCGCTCGGCCCCAGCTG

CAGGAAACAGCAGGCCCCGCCCTCTCACAGAGGATGGGTGAGGAGGCCAGACCTGCCCTG

CCCCATTGTCCAGATGGGCACTGCTGTGGAGTCTGCTTCTCCCATGTACCAGGGCACCAG

GCCCACCCAACTGAAGGCATGGCGGCGGGGTGCAGGGGAAAGTTAAAGGTGATGACGATC

ATCACACCTGTGTCGTTACCTCAGCCATCGGTCTAGCATATCAGTCACTGGGCCCAACAT

ATCCATTTTTAAACCCTTTCCCACAAATACACTGCGTCCTGGTTCCTGTTTAGCTGTTCT

GAAATACGGTGTGTAAGTAAGTCAGAACCCAGCTACCAGTGATTATTGCGAGGGCAATGG

GACCTCATAAATAAG

BQ549571

TTTTTTTTTTTTTTTTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCA

GTTCAAATACAATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATA

GTATATTACAAGTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTT

TACCTGGTTGCGAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGA

AACCGACCATCGGAGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTA

TTTATGAGGTCCCATTGCCCTCGCAATAATCACTGGTAGCTGGGTTCTGACTTACTTACA

CACCGTATTTCAGAACAGCTAAACAGGAACCAGGACGCAGTGTATTTGTGGGAAAGGGTT

TAAAAATGGATATGTTGGGCCCAGTGACTGATATGCTAGACCGATGGCTGAGGTAACGAC

ACAGGTGTGATGATCGTCATCACCTTTAACTTTCCCCTGCACCCCGCCGCCATGCCTTCC

AGTTGGGTGGGCCTGGT

AI693324

CTCTGAGCACTACAATCAGCCAGATTGGTTGACACAGATTCAAGATATTGCCAACAAAGT

CCTCTTGGCTCTGTTCACCTGCGAGATGCTGGTAAAAATGTACAGCTTGGGCCTCCAAGC

ATACTCTTGTTCTCTTTACAACCGGTTTGATTGCTTCGTGGTGTGTGGTGGAATCACTGA

GACGATCTTGGTGGAACTGGAAATCATGTCTCCCCTGGGGATCTCTGTGTTTCGGTGTGT

GCGCCTCTTAAGAATCTTCAAAGTGACCAGGCACTGGACTTCCCTGAGCAACTTAGTGGC

ATCCTTATTAAACTCCATGAAGTCCATCGCTTCGCTGTTGCTTCTGCTTTTTCTCTTCAT

TATCATCTTTTCCTTGCTTGGGATGCAGCTGTTTGGCGGCAAGTTTAATTTTGATG

R25307

ACCAGCAGACCTGACTGTCCCCAGCAGCTTCCGGAACAAAAACAGCGACAAGAGAGGAGT

GCGGACAGTTGGTGGAGGCAGTCCTGATATCCGAAGCTTGGGACGCTATGCAAGGGACCC

AAAATTTGTGTCAGCAACAAAACACGAAATCGCTGATGCCTGTGACCTCACCATCGACGA

GATGGAGAGTGCAGCCAGCACCCTGCTTAATGGGAACGTGCGTCCCCGAGCCAACGGGGA

TGTGGGCCCCCTCTCACACCGGCAGACTATGAGCTACAGGACTTTGGTCCTGGGCTTACA

GCGACGAAGAGCCAGACCCTGGGGAGGGATTGAGGGAGGACCTGGGCGGATGAATTGATT

TTGCNTCACCACCTTTGTTAGGCCCCCAGGCGAGGGGCAAG

R46658

TTTTTTTTTTNTTTTTTTTTTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTT

TAGAAAAATTTCTGTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTT

TCGCTGAATAAATGAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGNGTAAAAAT

ACTAAT

H29256

TTTTTTTTTTTTTTTTTTTTTGTGGAAAGATGATAGGTTTATAGNGACTCAAAATATTTT

AGAAAAATTTCTGTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTT

CGCTGAATAAATGAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATA

CTAATAATTTCTAGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGC

AGTTCAAATACAATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAANTTAT

AGNATATTACAAGTCATGTACAGTAAATCTATAATTTTGGACAANCTAGTGTATCTAAGT

TTACCNGGGGTGCGAGTGCCTTATTNTTCCNGTTTACAGTTGCCCTTAGCGTGACAGTCN

GGAACCGNCCTTC

H29339

GCCTGACTGTCCCCAGCAGCTTCCGGAACAAAAACAGCGACAAGCAGAGGAGTGCGGACA

NTTTGGTGGAGGCAGTCCTGATATCCGAAGCTTGGGACGCTATGCAAGGGACCCAAAATT

TGTGTCAGCAACAAAACACGAAATCGCTGATGCCTGTGACCTCACCATCGACGAGATGGA

GAGTGCAGCCAGCACCCTGCTTAATGGGAACGTGCGTCCCCGAGCCAACGGGGATGTGGG

CCCCCTCTCACACCGGCAGACTATGAGCTACAGGACTTTGGTCCTGGGCTACAGCGACGA

AGAGCCAGACCCTGGGAGGGATGAGGAGGAC

BG716371

AGCGGTCGTAATAATGTAGTTCCCCACTAAAATCTAGAAATTATTAGTATTTTTACTCGG

GCTATCCAGAAGTAGAAGAAATAGAGCAAATTCTCATTTATTCAGCGAAAATCCTCTGGG

GTTAAAATTTTAAGTTGAAAGAACTTGACACTACAGAAATTTTTCTAAAATATTTGAGTC

ACTATAAACCTATCATCTTTCCACAAGATATACCAGATGACTATTGCAGTCTTCTCTTGG

GCAAGAGTTCCATGATTTGATACTGTACCTTGGATCCACCATGGGTGCAACTGTCTTGGT

TTGTTGTTGACTTGAACCACCCTCTGGTAAGTAAGTGAATTACAGAGCAGGTCTAGCTGG

CTGCTCTGCCCCTTGGGTATCCATAGTTACGGTTTTCTCTGTGGCCCACCCAGGTGTTTT

TGCATCGCTGGTGCAGAAATGCACAGGTGGATGAGATATAGCTGCTCTTGTCCTCTGGGG

ACTGGTGGTGCTGCTTAAGAAATAAGGGGTGCTGGGGACAGAGGAGCAACGTGGTGATCT

ATAGGATTGGAGTGTCGGGGTCTGTACAAATCGTATTGTTGCCTTTTACAAAACTGTGTA

CTGTATGTTCTCTTTGAGGGCTTTTGTATGCAATTGAATGAGG

AI537488

TTTTCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTGT

AGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAATGA

GAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTAG

ATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAAT

ACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAAGT

CATGTACAGTAAATCTATAATTTTAAACAAACCTGTGTATCTAAGTTTACCTGGTTG

AA458692

GACAAATAAAGCAATTATAAATGTATCTCACTTTAGAACAGACAAAAAAAGGGCATGCTA

TGGAAATTGTTTAAATCTCAAGCAACAATGCTGATTAATTTCTGGTCAATAATCGTTCTA

TAGTTCTCCTTCATGAAGCCTGGTGAGGTTCCAGGAAACAGCTTGATTTGGGAAGCCTCA

GCAGAAAAGAAAGCATCTCAGAGGACACATAAAATGTCTGGCAACCCCTCTTGGCGGCCC

TCATCCAGCAAAGCTTGTGTGGTCTTGGCAACTGTCCTCAGGACTCTGCTTTCAAGATGA

AAGAGGTGTAGCTTACCCGCTCAATACACCAAGTACAAGATTTAGTACGAAAAATGACCC

AAAGATGACGAGACTGACAAGATACACCCAGGGCAATTCCAATCCCATAGCATCATTCAT

AI393327

TTTATATTATTCACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTTA

CTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATCCT

TTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTGG

GAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACAGGGCAGGTACTG

TGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCAATG

GTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCAAC

ATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCAAAAT

TGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTT

AI520947

TTTTTTTTTTTTTTTTTTTTTCTTACAAAGAAAAATTTAATATTCGATGAGAGGTTGAAC

CAGGCTTAAAGCAAACATACTAGGAAATGGGGCAGCCTGTAAGAATGCCAGTTTGTAAGT

ACTGACTTTGGAAAAGATCATCGCCTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTT

TGGCCTGATGTGATGCCACAAGACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTG

ACAGGGGGTAGCCCTTTAGGAGAAATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTG

GCACCGAAGGAACCAGGAGGATAAGAATAT

AI248998

TGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCT

TACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATC

CTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTT

GGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGTAC

TGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCAA

TGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCA

ACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCAAA

ATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCCAAAGTCAGTAC

TTACAAACTGGCATTCTTACAG

AI075844

TTTTTTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTT

AAGACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCT

GACATAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAAT

TTTTATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACG

GGGCAGGTACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCT

TCGGTGCCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTAC

ACCACTGTCAACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTG

AI869807

GTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTT

ACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATCC

TTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTG

GGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGCAGGTACTG

TGCCAGGGCAGCTCTGAAATATGGATATTCTTACCTCCTGGTTCTTTCGGTGCAAATGGT

AACCTAATACCAGCCGCAGGGAGCGCCATTTCT

AI869800

GTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTT

ACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATCC

TTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTG

GGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGNGCAGGTA6T

GTGCCAGGGCAGCTCTGAATTATGGATATTCTTATCCTCCTG

AI243110

TTTTTCTTACAAAGAAAAATTTAATATTCGATGAGAGGTTGAACCAGGCTTAAAGCAGAC

ATACTAGGAAATGGTGCAGCCTGTAAGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAG

ATCATCGCCTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGC

CACAAGACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACAGTGGTGTAGCCCT

TTAGGAGAAATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTGGCACCGAAGGAACCA

GGAGGATAAGAATATCCATAATTTCAGAGCTGCCCTGGCACAGTACCTGCCCCGTCGGAG

GCTCTCACTGGCAAATGACAGCTCTGTGCAAGGAGCACTC

AI955764

TTATCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTGT

AGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAATGA

GAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTAG

ATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAAT

ACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGGATATTACAAGG

CATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGCGA

GTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATCGG

AGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTATTTATGAGGTCCC

AT

AA192669

GCCCTCACAGCCCACCACGCCTGGCCTTCGCCCAATTCTGAAACTTCGTAGGATAGAGCT

GGAAAGTGCCACATGGTGAAGCGAGATCCAGCTGTCTGGGTGGATGTCGGAGTCCATAGG

CTGAGCAGAGATGGTTCTTAGTGAGGTTCTCGCTGCCAGTTGACGGTGAAATCATAGCTG

CCATTTACATTTTGTGAGATTATGAAAAACATAAGACTAAAGAAACTAAATGTGTTATTC

CTGTGGACACAAAAATGTGTGTTTTTCAGATGGGGAGGGGACCAAAAAGGAAAAACATTT

CATCTTAAAACTTTCCTAAGACAAAGGAAAACAAAAAACCATGCTCCTACAACTTCAAAT

TTTTCTTACCAAAGAAAAATTTAATATTCGATGAGAGGTTGAACCAGGCTTAAAGCAGAC

ATACTAGGGAATGGGTGCAGCCTGTAAGAATGCCAGTTT

AA192157

GTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTT

ACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATCC

TTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTG

GGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGTACT

GTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCAAT

GGTAACCTAATACCAGCCGCAGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCAAC

ATTATCCTGGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCAAAA

TTGGCCAGACCAGGACCCCAAGTGGTCTGATAGAAGGCGATGATCTTTTCCAAAGTCAGT

ACTTACA

AI361691

GTTTAAAATTATAGATTTACTGTACATGACTTGTAATATACTATAATTTGTATTTGTAAA

GAGATGGTCTATATTTTGTAATTACTGTATTGTATTTGAACTGCAGCAATATCCATGGGT

CCTAATAATTGTAGTTCCCCACTAAAATCTAGAAATTATTAGTATTTTTACTCGGGCTAT

CCAGAAGTAGAAGAAATAGAGCCAATTCTCATTTATTCAGCGAAAATCCTCTGGGGTTAA

AATTTTAAGTTTGAAAGAACTTGACACTACAGAAATTTTTCTAAAATATTTTGAGTCACT

ATAAACCTATCATCTTTCCACAAGATATACCAGATGACTATTTGCAGTCTTTTCTTTGGG

CAAGAGTTCCATGATTTTGATACTGTACCTTTGGATCCACCATGGGTTGCAACTGTCTTT

GGTTTTGTTTGTTTGACTTGAACCA

AI914244

TTCGCTGAATAAATGAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAA

TACTAATAATTTCTAGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCT

GCAGTTCAAATACAATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATT

ATAGTATATTACAAGTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAA

GTTTACCTGGTTGCGAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTC

AGAAACCGACCAT

AW008769

TTTTATCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCT

GTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAAT

GAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCT

AGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACA

ATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAA

GTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGC

GAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACC

AW008794

TTTTATCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCT

GTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAAT

GAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCT

AGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACA

ATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAA

GTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGC

GAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATC

GGAGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTATTTATTT

AA877582

TTTTTTTTTTAGAGCCAATTCTCATTTATTCAGCGAAAATCCTCTGGGGTTAAAATTTTA

AGTTTGAAAGAACTTGACACTACAGAAATTTTTCTAAAATATTTTGAGTCACTATAAACC

TATCATCTTTCCACAAGATATACCAGATGACTATTTGCAGTCTTTTCTTTGGGCAAGAGT

TCCATGATTTTGATACTGTACCTTTGGATCCACCATGGGTTGCAACTGTCTTTGGTTTTG

TTTGTTTGACTTGAACCACCCTCTGGTAAGTAAGTGAATTACAGAGCAGGTCCAGCTGGC

TGCTCTGCCCCTTGGGTATCCATAGTTACGGTTTTCTCTGTGGCCCACCCAGGGTGTTTT

TTGCATCGCTGGTGCAGAAATGCACAGGTGGATGAGATATAGCTGC

AI051972

TTTTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAA

GACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGA

CATAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTT

TTATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACAGG

GCAGGTACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTC

GGTGCCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACAC

CACTGTCAACATTATCCTGGACTCTGTGTCTCTCTCTGTTGAGTCTTGTGGCATCACATC

AGGCCAAAATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTT

AI017959

TTTAGAGCCAATTCTCATTTATTCAGCGAAAATCCTCTGGGGTTAAAATTTTAAGTTTGA

AAGAACTTGACACTACAGAAATTTTTCTAAAATATTTTGAGTCACTATAAACCTATCATC

TTTCCACAAGATATACCAGATGACTATTTGCAGTCTTTTCTTTGGGCAAGAGTTCCATGA

TTTTGATACTGTACCTTTGGATCCACCATGGGTTGCAACTGTCTTTGGTTTTGTTTGTTT

GACTTGAACCACCCTCTGGTAAGTAAGTGAATTACAGAGCAGGTCCAGCTGGCTGCTCTG

CCCCTTGGGTATCCATAGTTACGGTTTTCTCTGTGGCCCACCCAGGGTGTTTTTTGCATC

GCTGGTGCAGAAATGCACAGGTGGATGAGATATAGCTGCTCTTGTCCTCTGGGGACTGGT

GGTGCTGCTTAAGAAATAAGGGGTGCTGGGGACAGAGGAGCAA

N79331

TTTTTTTTTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTT

CTTAAGACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTT

CCTGACATAAATCCTTTTTG

N62240.1

ACAAAGAAAAATTTAATATTCGATGAGAGGTTGAACCAGGCTTAAAGCAGACATACTAGG

AAATGGTGCAGCCTGTAAGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAGATCATCGC

CTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGCCACAAGAC

CCAACAGAGAGAGACACAGAGTCCAGGNTAATATTGACAGNAGGTGGANGCCCCCCT

A1240933

TTTTTTTTTTTTTTTTTTTTGGTCCAAAATTTTTAATAGTATACAGACAACCTGTTAATT

TTTTTTTTTTTTTTTTTTGGAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACC

TCTTCTTAAGACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGGAAATGACT

CTTTCCTGACATAAATCCTTTTTTATTAAAATGCAAAAGGTTCTTCAGAATAAAACTGTG

TAATAATTTTTATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAG

AI015031

TTTTTCTTACAAAGAAAAATTTAATATTCGATGAGAGGTTGAACCAGGCTTAAAGCAGAC

ATACTAGGAAATGGTGCAGCCTGTAAGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAG

ATCATCGCCTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGC

CACAAGACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACAGTGGTGTAGCCCT

TTAGGAGAAATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTGGCACCGAAGAGACCA

GGAGGATAAGAATATCCATAATTTCAGAGCTGCCCTGGCACAGTACCTGCCCCGTCGGAG

GCTCTCACTGGCAAATGACAGCTCTGTGCAAGGAGCACTCCCAAGTATAAAAATTATTAC

ACAGTTTTATTCTG

AI290994

TAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTTA

CTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATCCT

TTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTGG

GAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGTACTG

TGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCAATG

GTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCAAC

ATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCAAAAT

TGCCAGACCAGGACCCTAAGTGTCTGATAGA

AA861160

TTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATT

CTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAA

TCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATAC

TTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGAC

AA915941

TTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTC

TTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAAT

CCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACT

TGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGAAGGGGCAGGTA

CTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCA

ATGGTAACCTAATACCAGCCGCAGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCA

ACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCAAA

ATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCCAAAGTCAGTAC

TTA

AA493341

GCTCGACTTTTTTTTTGGGGGAACGTTTTCATTAGGTTAACAGTGTTTGGCAAGCATTGG

AAACACGGAATCTCACAGACAGATACAGGCAGAAAGAATCACAGTTCAATCCAAAAGCAA

CACACTGAGAGGACATCAGAGTCCAAACACATGCAGAGAAGCTGTCAGGGAGCAGCTAGG

AGACACGCAGAGTTGCCTCACACGTGGCAGCAGGAGAAGGTGCAACACGGATCCGACTGC

TTACCCACTAAGGACACCAAGAACCAGGTTAAGGACGAAAAATGAGCCAAGGATGATCAG

ACTAACAAAATACACCCATGGCCATTCCCATCCTATCGCATCATTTACCCAGTAGAGCAC

GTCTGTCCAGCCCTCCATGGTGATGCACTGAAACACAGTAAGCATGGCAAAGGCAAAGTT

ATCAAAGTTGGTGATGCCTCCGTTCGGGCCAACCCAGCCACTCCTACATTCCGTGCCATT

GGCAGTACACTGGCGTCCATTCCCTGT

AI467998

TTTTTTTTTTTTTTTTTGGTCCAAAATTTTTAATAGTATACAGACAACCTGTTAATTTTT

TTTTTTTTTTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCT

TCTTAAGACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTT

TCCTGACATAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAA

TAATTTTTATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCC

GACGGGGCAGGTACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGT

TCCTTCGGTGCCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGG

CTACACCACTGTCAACATTATCC

AA885585

TTTTTTTTTTTTTTTTTTCTTACAAAGAAAAATTTAATATTCGATGAGAGGTTGAACCAG

GCTTAAAGCAGACATACTAGGAAATGGTGCAGCCTGTAAGAATGCCAGTTTGTAAGTACT

GACTTTGGAAAAGATCATCGCCTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGG

CCTGATGTGATGCCACAAGACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACA

GTGGTGTAGCCCTTTAGGAGAAATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTGGC

ACCGA

AI033648

TGTAAATAACAAACACCACTTGGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCT

TACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATC

CTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTT

GGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGTAC

TGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCAA

TGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCA

ACATTATCCTGGACTC

AI697633

ATTCCTGTTAATTTTGACAAGCTCAACGGCTGAAATCTAGGAATGGTTACTACCAAAAGC

CCACCCAATCCAGCTCATTTTGCTATCGTTTTATAACAATTAATCTGCATTATATTTGGA

TCCAGACAAATAAAGCAATTATAAATGTATCTCACTTTACAACAGACAAAAAAAGGGCAT

GCTATGGAAATTGTTTAAATCTCAAGCAACAATGCTGATTAATTTCTGGTCAATAATCGT

TCTATAGTTCTCCTTCATGAAGCCTGGTGAGGTTCCAGGAAACAGCTTGATTTGGGAAGC

CTCAGCAGAAAAGAAAGCATCTCAGAGGACACATAAAATGTCTGGCAACCCCTCTTGGCG

GCCCTCATCCAGCAAAGCTTGTGTGGTCTTGGCAACTGTCCTCAGGACTCTGCTTTCAAG

ATGAAAGAGGTGTAGCTTACCCGCTCAATACACCAAGTACAAGATTTAGTACGAAAAATG

ACCCAAAGATGACGAGACTGACACAATACACCCAGGGCAATTCAAATCCCATAGCATCAT

TCAT

AA523647

GGTCGACGTATTTGTAAAGAGATGGTCTATATCTTGTAATTACTGTATTGTATTTGAACT

GCAGCAATATCCATGGGTCCTAATAATTGTAGTTCCCCACTAAAATCTAGAAATTATTAG

TATTTTTACTCGGGCTATCCAGAAGTAGAAGAAATAGAGCCAATTCTCATTTATTCAGCG

AAAATCCTCTGGGGTTAAAATTTTAAGTTTGAAAGAACTTGACACTACAGAAATTTTTCT

AAAATATTTTGAGTCACTATAAACCTATCATCTTTCCACAAGAAAAAAAAACAAAAAAAA

AGTCGACG

BQ710377

CAAAGTACTTCCCCACATTTAGCTGGATTTGTCTTTGGTTTGAAGAGGCTAATACGTGAA

AGATTTGTTCACAGTTGGATGTCCCCTTTTCTGAACCATGAAGTAATATTGTGAATGGAG

TTGAATGCTGAGGTTAGGGTGCCGGAAAGATTCAGGGTCCTTCGGTACCCTCACATGGCT

TGGCTTTGGTAGAACAAGAAACTAAGCTCTGATTTGGCTTTAAATGAGAGTGCTAAATTT

CCTTTTTCTAATAAAGAACCTAGCTAAACATTTATATATACTTTTGAACACTGAACTTTC

TTGTTGCAGAGTTAACAGCTGTTGGGGGTAGCTGACAGCTGGATCCTGGTGCTGTTGGTA

CCATGGTACCTGAAGTGCACAGGCTGGTAGCCACACCTGACATTAACAAGTGAGTGGTAA

CCTCTCTGCCGCTGGCTCACAGCTACTGTTTCCATAGAAATGGCTGTCGGGATCAGTGGA

AACGAGGTAAGTGAAAGTTTTCGCTGATCCTTGTTTCCATCAAGCTGACGTCTGTTTCCC

TGGCAACAGCAGTGGACAGCAGCCAGGCGCTAGCAACAGATTCAGTAGAGCTCTCACTTG

TCAGCTGTGGCTATCATCTGTTCCTGACCAAGTTCTTTTTTTTTTTTTTAATAATGTACA

GAAAGACCTCTGANGGACCAGGANGCNACTCTGGCCACATGTGCCCTCCTGGATGCTCGT

TTTGCAAATGGAGAGCTGTGTGCTGAGTTGACTTCTCTGTCCGCAGTTCCCCCTCCACTG

NGGCTCTGGGGTTGNTGATGTGCAGGTAAAAAAAAGGAGGGTTGTTGAAGGTTATTAGTT

GTTCCAAGGGGAAGCCTGTTGAAACCTGGTTGATCCCCAATCCCTATGGGGAAGAAAAAT

CTCTTTAAGGGGCTTTTCATGCCCAGAGACCCAAATTTT

BQ706920

GGTGGCGATTCGGACGAGGGCAAAGACTTCCCCCATTTAGCTGGATTTGTCTTTGGTTTG

AAGAGGCTAATACGTGAAAGATTTGTTCACAGTTGGATGTCCCCTTTTCTGAACCATGAA

GTAATATTGTGAATGGAGTTGAATGCTGAGGTTAGGGTGCCGGAAAGATTCAGGGTCCTT

CGGTACCCTCACATGGCTTGGCTTTGGTAGAACAAGAAACTAAGCTCTGATTTGGCTTTA

AATGAGAGTGCTAAATTTCCTTTTTCTAATAAAGAACCTAGCTAAACATTTATATATACT

TTTGAACACTGAACTTTCTTGTTGCAGAGTTAACAGCTGTTGGGGGTAGCTGACAGCTGG

ATCCTGGTGCTGTTGGTACCATGGTACCTGAAGTGCACAGGCTGGTAGCCACACCTGACA

TTAACAAGTGAGTGGTAACCTCTCTGCCGCTGGCTCACAGCTACTGTTTCCATAGAAATG

GCTGTCGGGATCAGTGGAAACGAGGTAAGTGAAAGTTTTCGCTGATCCTTGTTTCCATCA

AGCTGACGTCTGTTTCCCTGGCAACAGCAGTGGACAGCAGCCAGGCGCTAGCAACAGATT

CAGGAGAGCTCTCACTTGTCAGCTGTGGCTATCATCTGTTCCTGACCAAGTTCTTTTTTT

TTTTTTTAATAATGGACAGAAAGACCTCTGAGGACCCAGGAGGCACCTCTGGGCACATGT

GCCCTCCTGGATGCTCCTTTTGCAGATGGAGACCTGGGGGCTGAGTTGACTTCTCTGGCC

GCAGTTCCCCCTCCACCTGGGGCTCCTGGGTGGTGAGGGGCCAGGTAAAAAAAGGGAAGG

TGTTTGAGGGTATTAATGGGTCCCCGGGCGGGCTGATCGAATCCTGGGGACTCCACGTCC

CTGGGGGGACAAGAATCTCTTCAACGGGGTTTTCCGGCCGGGAGCCGGAGTTTTTTATTC

AGCGGG

BQ016847

TTTTTTTTTTTTTTTTTTCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTT

AGAAAAATTTCTGTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTT

CGCTGAATAAATGAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATA

CTAATAATTTCTAGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGC

AGTTCAAATACAATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTAT

AGTATATTACAAGTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGT

TTACCTGGTTGCGAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAG

AAACCGACCATCGGAGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTT

ATTTATGAGGTCCCATTGCCCTCGCAATAATCACTGGTAGCTGGGTTCTGACTTACTTAC

ACACCGTATTTCAGAACAGCTAAACAGGAACCAGGACGCAGTGTATTTGGGGGAAAGGGT

TTACAAATGGATATGTTGGGCCCAGTGACTGATATGCTAGACCGATGGCTGAGGTAACGA

CACAGGTGTGATGATCGTCATCACCTTTAACT

CA943595

TGCAAATAAGGACAAGCTCAGCGGCTGAAATCTACAAATGGGGACTACCAAAAGCCCACC

CAATCCAGCTCATTTTGCTATCGTTTTATAACAATTAATCTGCATTATATTTGGATCCAG

ACAAATAAAGCAATTATAAATGTATCTCACTTTAGAACAGACAAAAAAAGGGCATGCTAT

GGAAATTGTTTAAATCTCAAGCAACAATGCTGATTAATTTCTGGTCAATAATCGTTCTAT

AGTTCTCCTTCATGAAGCCTGGTGAGGTTCCAGGAAACAGCTTGATTTGGGAAGCCTCAG

CAGAAAAGAAAGCATCTCAGAGGACACATAAAATGTCTGGCAACCCCTCTTGGCGGCCCT

CATCCAGCAAAGCTTGTGTGGTCTTGGCAACTGTCCTCAGGACTCTGCTTTCAAGATGAA

AGAGGTGTAGCTTACCCGCTCAATACACCAAGTACAAGATTTAGTACGAAAAATGACCCA

AAGATGACGAGACTGACAAAATACACCCAGGGCAATTCAAATCCCATAGCATCATTCATC

TGCAAGAAATAAGATGGTCTCATAGGAGTGGGTTAATAAGAGGATTTAATAAGGA

BM008196

GGCAAAGTACTTCCCCACATTTAGCTGGATTGGTCTTTGGTTTGAAGAGGCTAATACGTG

AAAGATTTGTTCACAGTTGGATGTCCCCTTTTCTGAACCATGAAGTAATATTGTGAATGG

AGTTGAATGCTGACGGTTAGGGTGCCGGAAAGATTCAGGGTCCTTCGGTACCCTCACATG

GCTTGGCTTTGGTAGAACAAGAAACTAAGCTCTGATTTGGCTTTAAATGAGAGTGCTAAA

TTTCCTTTTTCTAATAAAGAACCTAGCTAAACATTTATATATACTTTTGAACACTGAACT

TTCTTGTCAGCAGAGTTAACAGCTGTAGGGGGTAGCTGACACGGCTGGATCCTGGTGCTG

TTGGTACCATGGTACCTGAAGTGCACAGGCTGGTAGCCACACCTGACATTAACAACGTGA

GTGGTAACCTCTCTGCCGCTGGCTCACAGCTACTGTTTCCATCAGAAATGGCTGTCGGGC

TCACGTGGAAACGAGGTAAGTGAAAGTACGCTAGATCCTTGTTCCATCACAGCTGACGCT

CTGTTTCCCATGGCAACACCCAGCACGGACAAGCCGCCACGCCGCATAGACAACCACAAC

CACGTACAGCTCTCCACAAGTCAGCTCGTGGCTATCCATCATGTCCCTGAACAAGCCCAC

ACCACCCCCCCCCAAGCGACACAGCAACGAGCACCACCCGGACGAACCAAAGGACGGACC

CCCCTGCCCCAACCTCTCGCCCATCCGCGACAGACCCGCCAAGCAAACACGACAACCTAA

CAAAGCAGAGGGACAGACCCATAGCGCCCGCTACCGGAAGCGTACACCACTTCCCAACAG

TAAGGCCAAAAGAGCGACGCGGAGCACGTGAACGGATAAGAAAACGAGAGAAGGCACGGC

CGCATGGCAAACACACCAGCAAGCAGCAGACAGCACGTGGGCACGACACAGGACAGAAAG

CAGCCCACCTCAGAGGGGACCAACGAAGAGTCGCACGAC

BI769856

CTGGGCCCAACATATCCATTTTTAAACCCTTTCCCCCAAATACACTGCGTCCTGGTTCCT

GTTTAGCTGTTCTGAAATACGGTGTGTAAGTAAGTCAGAACCCAGCTACCAGTGATTATT

GCGAGGGCAATGGGACCTCATAAATAAGGTTTTCTGTGATGTGACGCCAGTTTACATAAG

AGAATATCACTCCGGTGGTCGGTTTCTGACTGTCACGCTAAGGGCAACTGTAAACTGGAA

TAATAATGCACTCGCAACCAGGTAAACTTAGATACACTAGTTTGTTTAAAATTATAGATT

TACTGTACATGACTTGTAATATACTATAATTTGTATTTGTAAAGAGATGGTCTATATTTT

GTAATTACTGTATTGTATTTGAACTGCAGCAATATCCATGGGTCCTAATAATTGTAGTTC

CCCACTAAAATCTAGAAATTATTAGTATTTTTACTCGGGCTATCCAGAAGTAGAAGAAAT

AGAGCCAATTCTCATTTATTCAGCGAAAATCCTCTGGGGTTAAAATTTTAAGTTTGAAAG

AACTTGACACTACAGAAATTTTTCTAAAATATTTTGAGTCACTATAAACCTATCATCTTT

CCACAAGATATACCAGATGACTATTTGCAGTCTTTTCTTTGGGCAAGAGTTCCATGATTT

TGATACTGTACCTTTGGATCCACCATGGGTTGCAN

BI758971

GGAAAAGAAATACTGTTTTAGAGAAATAACATTTTCAACAAAACATCCCTGGAGTCAGAT

TTTGAGTTGGGGTGGGCTAATCAGGGAGTCGGGGCTCTCTGCGTGATGTCAGTTCTATGG

CTAACTGGTTTTTCTAAACCAGCCAGCTGCCTATCAAAACAGTACAACTTTTCTAGGAAA

TGCAATTGGCAAAGACACTTACGATGCTGAGAAGTACACAAGGTGAAACTGCTCCAGTTT

TTCTCATAGCAGGGTCAGCAGGAAAGCAAGTGGTGCCCCTGGTCCCATCTCACACAGGTG

AGACTGCACCGAGAGGTAACGTGGCCCTCACAGCCCACCACGCCTGGCCTTCGCCCAATT

CTGAAACTTCGTAGGATAGAGCTGGAAAGTGCCACATGGTGAAGCGAGATCCAGCTGTCT

GGGTGGATGTCGGAGTCCATAGGCTGAGCAGAGATGGTTCTTAGTGAGGTTCTCGCTGCC

AGTTGACGGTGAAATCATAGCTGCCATTTACATTTTGTGAGATTATGAAAAACATAAGAC

TAAAGAAACTAAATGTGTTATTCCTGTGGACACAAAAATGTGTGTTTTTCAGATGGGGAG

GGGACCAAAAAGGAAAAACATTTCATCTTAAAACTTTCCTAAGACAAAGGAAAACAAAAA

ACCATGCTCTACAACTTCAAATTTTTCTTACAAAGAAAAATTTAATATTCGATGAGCAGG

TTGAACCAGGCTTAAAGCAGACATACTAGGAAATGGTGCAGCCTGTAAGAATGCCAGTTT

GTAAGTACTGACTTTGGAAAAGATCATCGCTCTATCAGACACTTAGGGTCCTGGTCTGGC

CATTTTGGCCTGATGTGATGCCAAAAGACC

AA468565

TTTTATCGTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCT

GTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAAT

GAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCT

AGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACA

ATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAA

GTCATGTACAGTAAATCTATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGCGAG

TGCATTAT

AA437099

CTTACAAAGAAAAATTTAATATTCGATGAGAGGTTGAACCAGGCTTAAAGCAGACATACT

AGGAAATGGTGCAGCCTGTAAGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAGATCAT

CGCCTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGCCACAA

GACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACAGTGGTGTAGCCCTTTAGG

AGAAATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTGGCACCGAAGAGACCAGGAGG

ATAAGAATATCCATAATTTCAGAGCTGCCCTGGCACAGTACCTGCCCCGTCGGAGGCTCT

CACTGGCAAATGACAGCTCTGTGCAAGGAGCACTCCCAAGTATAAAAATTAT

CA867864

CCGCGTCCGGTCAGATGGTACAAGTTTGTCTCTATAATTAAGACTTTTCCACCATCACAA

ACTTTAAACACAAAGTCTAAAATCTTGGGCAGCATAGAAAATAGGTTCTAGCTAAGCAGG

AGTTTTGTCCTCTACCAAGACCTTTCCTGAAAATCACTTATCAAGACAGTTTCCTGTAAG

AAAAAGCCATATCCCAGCTGATTTTCCTTCCTGGGGCCAAAATCTGCTATTATTCGGCCT

GAAAGCCTTGATGACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGT

GTATGGATGCTTGTGTGTGTGTATGGGGAATATGTGATTAATGTGTGTTGGCTGCTGTTG

TCTCTGATTTGGCTACTGTTGTTTCTGATTTAAATCTAAGTAAATGTTTAATTAAATGTA

TAGAATGCTGTCTCTAATGTGACCCTCTCTCCTTATTAAATCCTCTTATTAACCCACTCC

TATGAGACCATCTTATTTCTTGCAGATGAATGATGCTATGGGATTTGAATTGCCCTGGGT

GTATTTTGTCAGTCTCGTCATCTTTGGGTCATTTTTCGTACTAAATCTTGTACTTGGTGT

ATTGAGCGGG

AA682690

AATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTGGGATGTGCTCC

TTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCGACAGGCAGGTACTGTGCCAGGGCAG

CTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCTGTGCTCAATGGTAACCTAAT

ACCAGCCGCAGGACNCGCCATTTCTCCTAAAGGGCTACACCACTGTCAACATTATC

AA701888

TCAGCGAAAATCCTCTGGGGTTAAAATTTTAAGTTTGAAAGAACTTGACACTACAGAAAT

TTTTCTAAAATATTTTGAGTCACTATAAACCTATCATCTTTCCACAAGATATACCAGATG

ACTATTTGCAGTCTTTTCTTTGGGCAAGAGTTCCATGATTTTGATACTGTACCTTTGGAT

CCACCATGGGTTGCAACTGTCTTTGGTTTTGTTTGTTTGACTTGAACCACCCTCTGGTAA

GTAAGTAAGTGAATTACAGAGCAGGTCCAGCTGGCTGCTCTGCCCCTTGGGTATCCATAG

TTACGGTTTTCTCTGTGGCCCACCCAGGGTGTTTTTTGCATCGCTGGTGCAGAAATGCAT

AGGTGGATGAGATATAGCTGCTCTTGTCCTCTGGGGACTGGTGGTGCTGCTTAAGAAATA

AGGGGTG

BU182632

TTTTGTCAGTCTCGTCATCTTTGGGTCATTTTTCGTACTAAATCTTGTACTTGGTGTATT

GAGCGGGCACAGTGGCTCACGCCTATAATCCCAGCACTTTCGGAGGCCGAGGCAGCTGGA

CCACCCGAGATCAGGAGTTTGAGACCAGCCTGACTAAGGCAGTGAAACCCTGTCTCTACT

AAAAATACAAAAATTAGCCAGGCATGGTGGCGCATGCCTGTAATCCCAGCTACTTGGGAG

GCTGAGGCAGGAGAATCACTTGAACCAGGGAGGTGGAGATTGCAGTGAGCCAAGACTGCA

CCATTGCATTCCAGCCTGGGTGACAAGAGCAAAACTCCATCTCAAAAAAAAAAAAAAAAA

AAAAAAAAAAAGACTTTTCTCTCATTCAACACTTTACCAGCATCTACTGACAGAAAATGG

ACAATTGAATTTCCTCCAATATATATACCTCTGATATGTCTGCTTTGTAAAAGAGTAGTG

TAATTGCTTACAACATTGAAAAGGTTGTTATTGGGGTCCTGGGGTAGCCAGGATATCGGC

ATGATTTGTCACCATATTCAGAATAAAACTGTACTGCAATAGTGAGTTAATTCCATATCT

TGGCCAACAGAGAATTTTTGGCCAGTGGCTACTAAGGCACACGGAAGTCCAGTCTAAAAG

GGACAGGGGAGGACTCTTTGTAGATAGTTCTTATGATTAAAAAATAACTTCCTATGTGTT

GTAGTGATGATTTAAGCTGACAGAATGCTAAAGACACCCCTTATGATTACCTGGTAGCAA

AGTACCTTCCCCACATTTAACCTGGATTTGCCCTTTTGGGTTTGAAAGAGGCTAAATA

BQ898429

GGTGGGATTCGGCACGAGGGCAAGACTTCCCCACATTTAGCTGGATTTGTCTTTGGTTTG

AAGAGGCTAATACGTGAAAGATTTGTTCACAGTTGGATGTCCCCTTTTCTGAACCATGAA

GTAATATTTGTGATATGGAGTTCGAATGGCTGAGGTCTAGGTGTGCCGAGAAAGATTCAG

GGTCCTTCGGTACCCTCACATGGCTTGGCTTTGGTAGAACAAGAAACTAAGCTCTGATTT

GGCTTTAAATGAGAGTGCTAAATTTCCTTTTTCTAATAAAGAACCTAGCTAAACATTTAT

ATATACTTTTGAACACTGAACTTTCTTGTTGCAGAGTTAACAGCTGTTGGGGGTAGCTGA

CAGCTGGATCCTGGTGCTGTTGGTACCATGGTACCTGAAGTGCACAGGCTGGTAGCCACA

CCTGACATTAACAAGTGAGTGGTAACCTCTCTGCCGCTGGCTCACAGCTACTGTTTCCAT

AGAAATGGCTGTCGGGATCAGTGGAAACGAGGTAAGTGAAAGTTTTCGCTGATCCTTGTT

TCCATCAAGCTGACGTCTGTTTCCCTGGCAACAGCAGTGGACAGCAGCCAGGCGCTAGCA

ACAGATTCAGTAGAGCTCTCACTTGTCAGCTGTGGCTATCATCTGTTCCTGACCAAGTTC

TTTTTTTTTTTTTTAATAATGTACAGAAAGACCTCTGAGGACCCAGGAGGCACCTCTGGC

CACATGTGCCCTCCTGGATGCTCGTTTTGCAGATGGAGAGCTGTGTGCTGAGTTGACTTC

TCTGTCCGCAGTTCCCCCTCCACCTGTGCTCTGGGTTGTTGATGTGCCAGTTAAAACAGG

GAGGCTGCTTCAGGGTATTAGTGTTGCCAAGGGGAGGCTGTTGAAATCTGGTTGATCCCA

AATC

BQ711800

CAAAGTACTTCCCCACATTTAGCTGGATTTGTCTTTGGTTTGAAGAGGCTAATACGTGAA

AGATTTGTTCACAGTTGGATGTCCCCTTTTCTGAACCATGAAGTAATATTGTGAATGGAG

TTGAATGCTGAGGTTAGGGTGCCGGAAAGATTCAGGGTCCTTCGGTACCCTCACATGGCT

TGGCTTTGGTAGAACAAGAAACTAAGCTCTGATTTGGCTTTAAATGAGAGTGCTAAATTT

CCTTTTTCTAATAAAGAACCTAGCTAAACATTTATATATACTTTTGAACACTGAACTTTC

TTGTTGCAGAGTTAACAGCTGTTGGGGGTAGCTGACAGCTGGATCCTGGTGCTGTTGGTA

CCATGGTACCTGAAGTGCACAGGCTGGTAGCCACACCTGACATTAACAAGTGAGTGGTAA

CCTCTCTGCCGCTGGCTCACAGCTACTGTTTCCATAGAAATGGCTGTCGGGATCAGTGGA

AACGAGGTAAGTGAAAGTTTTCGCTGATCCTTGTTTCCATCAAGCTGACGTCTGTTTCCC

TGGCAACAGCAGTGGACAGCAGCCAGGCGCTAGCAACAGATTCAGTAGAGCTCTCACTTG

TCAGCTGTGGCTATCATCTGTTCCTGACCAAGTTCTTTTTTTTTTTTTTAATAATGTACA

GAAAGACCTCTGAGGACCCAGGGAGCACCTCTGGCCACATGTGCCCTCCTGAATGCTCGT

TTTGCAAATGGAGAGCTGTGTGCTGAGTTGACTTCTCTGTCCGCAGGTCCCCCTCCAACT

GTGCTCCTGGGTTGTGATGTGCAGGGTTAAACCAGGGAAGCTGTTGAAGGGTATTAGTGT

TGCCAGGGAAAGGCTGTTGAATTCTGGTTGATCCCAAATCCCTAGGGGGAAGAGAAATCC

CTTACGAGTGGTTTTTCATGGCCAGGAACCCTATA

AA703120

TCAGCGAAAATCCTCTGGGGTTAAAATTTTAAGTTTGAAAGAACTTGACACTACAGAAAT

TTTTCTAAAATATTTTGAGTCACTATAAACCTATCATCTTTCCACAAGATATACCAGATG

ACTATTTGCAGTCTTTTCTTTGGGCAAGAGTTCCATGATTTTGATACTGTACCTTTGGAT

CCACCATGGGTTGCAACTGTCTTTGGTTTTGTTTGTTTGACTTGAACCACCCTCTGGTAA

GTAAGTAAGTGAATTACAGAGCAGGTCCAGCTGGCTGCTCTGCCCCTTGGGTATCCATAG

TTACGGTTTTCTCTGTGGCCCACCCAGGGTGTTTTTTGCATCGCTGGTGCAGAAATGCAT

AGGTGGATGAGATATAGCTGCT

AA978315

GTATATCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCT

GTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAAT

GAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCT

AGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATAGCTGCAGTTCAAATACA

ATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAA

GTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCAGGTTGC

GAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATC

GGAGTGATATTCTCTTATGTAAACAGGCGTCACATCACAGA

BE550599

TTTTTTTTTTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTT

CTGTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAA

ATGAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTT

CTAGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATA

CAATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTAC

AAGTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTT

GCGAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCA

TCGGAGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTATTTATGAGG

TCCCATTGCCCTCGCAATAATCACTGGTAGCTGGGTTCTGACTTACTTACACACCGTATT

TCAGAACAGCTAAACAG

BE502741

TTTGGTATATCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAAT

TTCTGTAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAAT

AAATGAGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAAT

TTCTAGATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAA

TACAATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATT

ACAAGTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGG

TTGCGAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGAC

CATCGGAGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTATTTATGA

G

AW872382

TTTTTTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTGT

AGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAATGA

GAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTAG

ATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAAT

ACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAAGT

CATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGCGA

GTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATCGG

AGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTT

AW444663

CGGCCGCCAACTTTTTTGAATGAGTGAAGTGCCAGGTACCATGAGAAAACCCTAGCTGGT

AAAGATCAAACCTGAGTTAGTTCTAAATTCACATACGGATTTTTTTTGCATGACGAAATC

TATTCTCTTTTTCCTGACAACTTCTCCACCTAGATGTTTGGGAAAGTTGCCATGAGAGAT

AACAACCAGATCAATAGGAACAATAACTTCCAGACGTTTCCCCAGGCGGTGCTGCTGCTC

TTCAGGTGACTGCAACTGGCTTGGGCGGTGCTCCTGGGCAGGGGGGTCCGCTAGGCGTGG

GTCCAGAGGGACGGAGGACACAGGTTATTAAAGCAGTGTGCCTTTCTCAGTTG

AW341279

TAAATAACTAACACCATTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTTA

CTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATCCT

TTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTG

GGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGTACT

GTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCAAT

GGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCAA

CATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCAAAA

TTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCCAAAGTCAGTACT

TACAAACTGGCATTCTTACAGGCTGCACCATTTCCTAGTATGTCTG

CF456750

ACTTTTCTAGGAAATGCAATTGGCAAAGACACTTACGATGCTGAGAAGTACACAAGGTGA

AACTGCTCCAGTTTTTCTCATAGCAGGGTCAGCAGGAAAGCAAGTGGTGCCCCTGGTCCC

ATCTCACACAGGTGAGACTGCACCGAGAGGTAACGTGGCCCTCACAGCCCACCACGCCTG

GCCTTCGCCCAATTCTGAAACTTCGTAGGATAGAGCTGGAAAGTGCCACATGGTGAAGCG

AGATCCAGCTGTCTGGGTGGATGTCGGAGTCCATAGGCTGAGCAGAGATGGTTCTTAGTG

AGGTTCTCGCTGCCAGTTGACGGTGAAATCATAGCTGCCATTTACATTTTGTGAGATTAT

GAAAAACATAAGACTAAAGAAACTAAATGTGTTATTCCTGTGGACACAAAAATGTGTGTT

TTTCAGATGGGGAGGGGACCAAAAAGGAAAAACATTTCATCTTAAAACTTTCCTAAGACA

AAGGAAAACAAAAAACCATGCTCTACAACTTCAAATTTTTCTTACAAAGAAAAATTTAAT

ATTCGATGAGAGGTTGAACCAGGCTTAAAGCAGACATACTAGGAAATGGTGCAGCCTGTA

AGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAGATCATCGCCTCTATCAGACACTTAG

GGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGCCACAAGACCCAACAGAGAGAGACAC

AGAGTCCAGGATAATGTTGACAGTGGTGTA

AW139850

TTTTTTTTTTTTTTTTTAGAAGAAATAGAGCCAATTCTCATTTATTCAGCGAAAATCCTC

TGGGGTTAAAATTTTAAGTTTGAAAGAACTTGACACTACAGAAATTTTTCTAAAATATTT

TGAGTCACTATAAACCTATCATCTTTCCACAAGATATACCAGATGACTATTTGCAGTCTT

TTCTTTGGGCAAGAGTTCCATGATTTTGATACTGTACCTTTGGATCCACCATGGGTTGCA

ACTGTCTTTGGTTTTGTTTGTTTGACTTGAACCACCCTCTGGTAAGTAAGTGAATTACAG

AGCAGGTCCAGCTGGCTGCTCTGCCCCTTGGGTATCCATAGTTACGGTTTTCTCTGTGGC

CCACCCAGGGTGTTTTTTGCATCGCTGGTGCAGAAATGCACAGGTGGATGAGATATAGCT

GCTCTTGTCCTC

AW029633

TTATCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTGT

AGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAATGA

GAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTAG

ATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAAT

ACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAAGT

CATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGCGA

GTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATCGG

AGTGATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTATTTATGAGGTCCC

ATTGCCCTCGCAATAATCACTG

AI963788

TTTTTCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTG

TAGTGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAATG

AGAATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTA

GATTTTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAA

TACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAAG

TCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGT

AI951788

ATCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTGTAG

TGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAATGAGA

ATTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTAGAT

TTTAGTGGGGAACCTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAATA

CAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAAGTC

ATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGCGAG

TGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATCGGA

GTGATATTCTCTTATGTAAACT

AI680744

TTTTCTTCAAATAATTACAAGCTCAGCGGCTGAAATCTACAAATGGGGACTACCAAAAGC

CCACCCAATCCAGCTCATTTTGCTATCGTTTTATAACAATTAATCTGCATTATATTTGGA

TCCAGACAAATAAAGCAATTATAAATGTATCTCACTTTAGAACAGACAAAAAAAGGGCAT

GCTATGGAAATTGTTTAAATCTCAAGCAACAATGCTGATTAATTTCTGGTCAATAATCGT

TCTATAGTTCTCCTTCATGAAGCCTGGTGAGGTTCCAGGGAAACAGCTTGATTTGGGAAG

CCTCAGCAGAAAAGAAAGCATCTCAGAGGACACATAAAATGTCTGGCAACCCCTCTTGGC

GGCCCTCATCCAGCAAAGCTTGTGTGGTCTTGGCAACTGTCCTCAGGACTCTGCTTTCAA

GATGAAAGAGGTGTAGCTTACCCGCTCAATACACCAAGTACAAGATTTAGTACGAAAAAT

GACCCAAAGATGACGAGACTGACAAAATACACCCAGGGCAATTCAAATCCCATAGCATCA

TTCATCTGCAAG

AI601252

TTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATT

CTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAA

TCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATAC

TTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGT

ACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCC

AATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGT

CAACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCA

AAATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCCAAAGTCAGT

ACTTACAAACT

AI459166

TTTTTTTTTGGTCCAAAATTTTTAATAGTATACAGACAACCTGTTAATTTTTTTTTTTTT

TTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGA

CATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACA

TAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTT

ATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGC

AGGTACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGG

TGCCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTT

AA885750

TCGACAGCTACCAGTGATTATTGCGAGGGCAATGGGACCTCATAAATAAGGTTTTCTGTG

ATGTGACGCCATTTACATAAGAGAATATCACTCCGATGGTCGGTTTCTGACTGTCACGCT

AAGGGCAACTGTAAACTGGAATAATAATGCACTCGCAACCAGGTAAACTTAGATACACTA

GTTTGTTTAAAATTATAGATTTACTGTACATGACTTGTAATATACTATAATTTGTATTTG

TAAAGAGATGGTCTATATTTTGTAATTACTGTATTGTATTTGAACTGCAGCAATATCCAT

GGGTCCTAATAATTGTAGTTCCCCACTAAAATCTAGAAATTATTAGTATTTTTACTCGGG

CTATCCAGAAGTAGAAGAAATAGAGCC

BX092736

GAATATGTGATTAATGTGTGTTGGCTGCTGTTGTCTCTGATTTGGCTACTGTTGTTTCTG

ATTTAAATCTAAGTAAATGTTTAATTAAATGTATAGAATGCTGTCTCTAATGTGACCCTC

TCTCCTTATTAAATCCTCTTATTAACCCACTCCTATGAGACCATCTTATTTCTTGCAGAT

GAATGATGCTATGGGATTTGAATTGCCCTGGGTGTATTTTGTCAGTCTCGTCATCTTTGG

GTCATTTTTCGTACTAAATCTTGTACTTGGTGTATTGAGCGGGTAAGCTACACCTCTTTC

ATCTTGAAAGCAGAGTCCTGAGGACAGTTGCCAAGACCACACAAGCTTTGCTGGATGAGG

GCCGCCAAGAGGGGTTGCCAGACATTTTATGTGTCCTCTGAGATGCTTTCTTTTCTGCTG

AGGCTTCCCAAATCAAGCTGTTTCCTGGAACCTCACCAGGCTTCATGAAGGAGA

BX114568

TTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATT

CTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAA

TCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATAC

TTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGT

ACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCC

AATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGT

CAACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCA

AAATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCCAAAGTCAGT

ACTTACAAACTGGCATTCTTACAGGCTGCACCATTTCCTAGTATGTCTGCTTTAAGCCTG

GTTCAACCTCTCATCGAATATTAAATTTTTCTTTGTAAGAAAAAAAAAAAAAAA

BE672659

TTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATT

CTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAA

TCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATAC

TTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACAGGGCAGGT

ACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCC

AATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGT

CAACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCA

AAATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCCAAAGTCAGT

ACTTACAAACTGGCATTCTTACAGGCTGCACCATTTCCTAGTATGTCTGCTTTAAGCCTG

GTTCAACC

N78509

GGAGAAAGGAGGGAAACCAGGAGCAGCCGGCATGGGCAGTGGCAGAATTGGCCCTGNTAG

AGAGCAGAGCTGATGCCATCCTTTTGGCAAATAGCTGACATTTTATGGTGTGGTGCTGGG

TGAGCCCCCTGTGAGGGTTGAACAGATGTGGACAGGACTTGGGTCCAGGCACTAGAGTGG

TGCAGCCTGTAAGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAGATCATCGCCTCTAT

CAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGCCACAAGACCCAACA

GAGAGAGACACAGAGTCCAGGATNAATGTTGACAGTGGTGTAGCCTTTAGGAAGAAATGG

CGCTCCCTGCGGCTGGTATTAGGTTACCATTGGCANCCGAAGGAACCCAGGAGGATTAAG

AATTTCCCTAATTTCAGAACTTGCCCTGGCACAGTA

N73668

GGTCCAAAATTTTTAATAGTATACAGACAACCTGTTAATTTTTTTTTTTTTTTTTTTTGT

AAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTTAC

TCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATCGACTCTTTCCTGACATAAATCCT

TTTTTATTAAAATNGCAAAATTGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTT

GGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGTAC

TGTGCCAGGGCAGCTCTGAAATTATGGAAATTCTTATCCCCCTGGTTCCTNCGGTGGCCA

ATGGGTAACCTAATACCAGCCCGCGGGAAGCGCCAATTTCNCCCAAAAGGGGGTAAACCA

CTGGTNAAACATTA

N46744

TTTTTCTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTA

AGACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTG

ACATAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATT

TTTATANGTGGGGGNGCTC

N39597

ACAAAGAAAAATTTAATATTCGATGAGAGGTTGAACCAGGCTTAAAGCAGACATACTAGG

AAATGGTGCAGCCTGTAAGAATGCCAGTTTGTAAGTACTGACTTTGGAAAAGATCATCGC

CTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGATGTGATGCCACAAGAC

CCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACAGTGGTGTAGCCCTTTAGGAGA

AATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTGGCACCGAAGAACCAGGAGGATAA

GAATATCCATAATTTCAGAGCTTGCCCTGGCACAGTACCTGCCCCGTCGGAGGCTCTCAC

TGGGCAAATGGACAGCTCTGTGCAAGGAGCACTCCCAAGTATAANAATTATTACACAGTT

TTATTCTGAAGAACATTTTGCATTTTAATAAAAAANGGA

BF439267

TTTTTTTTTTTTTTGGGCCAAAATTTTTAATAGTATACAGACAACCTGTTAATTTTTTTT

TTTTTTTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTTT

TAAGACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTTTTTCC

TGACATAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAA

TTTTTATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGAC

GGGGCAGGTACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCC

TTCGGTGCCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTA

CACCACTGTCAACATTATCCTGG

BF436153

TTTTTTTTTGGTCCAAAATTTTTAATAGTATACAGACAACCTGTTAATTTTTTTTTTTTT

TTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGA

CATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACA

TAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTT

ATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGC

AGGTACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGG

TGCCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCA

CTGTCAACATTATCCTGGACTC

BF110611

TTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTGTAGTG

TCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAAATGAGAA

TTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTAGATT

TTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAATACA

GTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGTATATTACAAGTCAT

GTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTACCTGGTTGCGAGTG

CATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATCGGAGT

GATATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTATTTATGA

M76558

gggcgagcgc ctccgtcccc ggatgtgagc tccggctgcc cgcggtcccg agccagcggc

gcgcgggcgg cggcggcggg caccgggcac cgcggcgggc gggcagacgg gcgggcatgg

ggggagcgcc gagcggcccc ggcggccggg ccggcatcac cgcggcgtct ctccgctaga

ggaggggaca agccagttct cctttgcagc aaaaaattac atgtatatat tattaagata

atatatacat tggattttat ttttttaaaa agtttatttt gctccatttt tgaaaaagag

agagcttggg tggcgagcgg ttttttttta aaatcaatta tccttatttt ctgttatttg

tccccgtccc tccccacccc cctgctgaag cgagaataag ggcagggacc gcggctccta

cctcttggtg atccccttcc ccattccgcc cccgccccaa cgcccagcac agtgccctgc

acacagtagt cgctcaataa atgttcgtgg atgatgatga tgatgatgat gaaaaaaatg

cagcatcaac ggcagcagca agcggaccac gcgaacgagg caaactatgc aagaggcacc

agacttcctc tttctggtga aggaccaact tctcagccga atagctccaa gcaaactgtc

ctgtcttggc aagctgcaat cgatgctgct agacaggcca aggctgccca aactatgagc

acctctgcac ccccacctgt aggatctctc tcccaaagaa aacgtcagca atacgccaag

agcaaaaaac agggtaactc gtccaacagc cgacctgccc gcgccctttt ctgtttatca

ctcaataacc ccatccgaag agcctgcatt agtatagtgg aatggaaacc atttgacata

tttatattat tggctatttt tgccaattgt gtggccttag ctatttacat cccattccct

gaagatgatt ctaattcaac aaatcataac ttggaaaaag tagaatatgc cttcctgatt

atttttacag tcgagacatt tttgaagatt atagcgtatg gattattgct acatcctaat

gcttatgtta ggaatggatg gaatttactg gattttgtta tagtaatagt aggattgttt

agtgtaattt tggaacaatt aaccaaagaa acagaaggcg ggaaccactc aagcggcaaa

tctggaggct ttgatgtcaa agccctccgt gcctttcgag tgttgcgacc acttcgacta

gtgtcaggag tgcccagttt acaagttgtc ctgaactcca ttataaaagc catggttccc

ctccttcaca tagccctttt ggtattattt gtaatcataa tctatgctat tataggattg

gaacttttta ttggaaaaat gcacaaaaca tgtttttttg ctgactcaga tatcgtagct

gaagaggacc cagctccatg tgcgttctca gggaatggac gccagtgtac tgccaatggc

acggaatgta ggagtggctg ggttggcccg aacggaggca tcaccaactt tgataacttt

gcctttgcca tgcttactgt gtttcagtgc atcaccatgg agggctggac agacgtgctc

tactggatga atgatgctat gggatttgaa ttgccctggg tgtattttgt cagtctcgtc

atctttgggt catttttcgt actaaatctt gtacttggtg tattgagcgg agaattctca

aaggaaagag agaaggcaaa agcacgggga gatttccaga agctccggga gaagcagcag

ctggaggagg atctaaaggg ctacttggat tggatcaccc aagctgagga catcgatccg

gagaatgagg aagaaggagg agaggaaggc aaacgaaata ctagcatgcc caccagcgag

actgagtctg tgaacacaga gaacgtcagc ggtgaaggcg agaaccgagg ctgctgtgga

agtctctgtc aagccatctc aaaatccaaa ctcagccgac gctggcgtcg ctggaaccga

ttcaatcgca gaagatgtag ggccgccgtg aagtctgtca cgttttactg gctggttatc

gtcctggtgt ttctgaacac cttaaccatt tcctctgagc actacaatca gccagattgg

ttgacacaga ttcaagatat tgccaacaaa gtcctcttgg ctctgttcac ctgcgagatg

ctggtaaaaa tgtacagctt gggcctccaa gcatatttcg tctctctttt caaccggttt

gattgcttcg tggtgtgtgg tggaatcact gagacgatct tggtggaact ggaaatcatg

tctcccctgg ggatctctgt gtttcggtgt gtgcgcctct taagaatctt caaagtgacc

aggcactgga cttccctgtg caacttagtg gcatccttat taaactccat gaagtccagt

gcttcgctgt tgcttctgct ttttctcttc attatcatct tttccttgct tgggatgcag

ctgtttggcg gcaagtttaa ttttgatgaa acgcaaacca agcggagcac ctttgacaat

ttccctcaag cacttctcac agtgttccag atcctgacag gcgaagactg gaatgctgtg

atgtacgatg gcatcatggc ttacgggggc ccatcctctt caggaatgat cgtctgcatc

tacttcatca tcctcttcat ttgtggtaac tatattctac tgaatgtctt cttggccatc

gctgtagaca atttggctga tgctgaaagt ctgaacactg ctcagaaaga agaagcggaa

gaaaaggaga ggaaaaagat tgccagaaaa gagagcctag aaaataaaaa gaacaacaaa

ccagaagtca accagatagc caacagtgac aacaaggtta caattgatga ctatagagaa

gaggatgaag acaaggaccc ctatccgcct tgcgatgtgc cagtagggga agaggaagag

gaagaggagg aggatgaacc tgaggttcct gccggacccc gtcctcgaag gatctcggag

ttgaacatga aggaaaaaat tgcccccatc cctgaaggga gcgctttctt cattcttagc

aagaccaacc cgatccgcgt aggctgccac aagctcatca accaccacat cttcaccaac

ctcatccttg tcttcatcat gctgagcagt gctgccctgg ccgcagagga ccccatccgc

agccactcct tccggaacac gatactgggt tactttgact atgccttcac agccatcttt

actgttgaga tcctgttgaa gatgacaact tttggagctt tcctccacaa aggggccttc

tgcaggaact acttcaattt gctggatatg ctggtggttg gggtgtctct ggtgtcattt

gggattcaat ccagtgccat ctccgttgtg aagattctga gggtcttaag ggtcctgcgt

cccctcaggg ccatcaacag agcaaaagga cttaagcacg tggtccagtg cgtcttcgtg

gccatccgga ccatcggcaa catcatgatc gtcaccaccc tcctgcagtt catgtttgcc

tgtatcgggg tccagttgtt caaggggaag ttctatcgct gtacggatga agccaaaagt

aaccctgaag aatgcagggg acttttcatc ctctacaagg atggggatgt tgacagtcct

gtggtccgtg aacggatctg gcaaaacagt gatttcaact tcgacaacgt cctctctgct

atgatggcgc tcttcacagt ctccacgttt gagggctggc ctgcgttgct gtataaagcc

atcgactcga atggagagaa catcggccca atctacaacc accgcgtgga gatctccatc

ttcttcatca tctacatcat cattgtagct ttcttcatga tgaacatctt tgtgggcttt

gtcatcgtta catttcagga acaaggagaa aaagagtata agaactgtga gctggacaaa

aatcagcgtc agtgtgttga atacgccttg aaagcacgtc ccttgcggag atacatcccc

aaaaacccct accagtacaa gttctggtac gtggtgaact cttcgccttt cgaatacatg

atgtttgtcc tcatcatgct caacacactc tgcttggcca tgcagcacta cgagcagtcc

aagatgttca atgatgccat ggacattctg aacatggtct tcaccggggt gttcaccgtc

gagatggttt tgaaagtcat cgcatttaag cctaaggggt attttagtga cgcctggaac

acgtttgact ccctcatcgt aatcggcagc attatagacg tggccctcag cgaagcagac

ccaactgaaa gtgaaaatgt ccctgtccca actgctacac ctgggaactc tgaagagagc

aatagaatct ccatcacctt tttccgtctt ttccgagtga tgcgattggt gaagcttctc

agcagggggg aaggcatccg gacattgctg tggactttta ttaagttctt tcaggcgctc

ccgtatgtgg ccctcctcat agccatgctg ttcttcatct atgcggtcat tggcatgcag

atgtttggga aagttgccat gagagataac aaccagatca ataggaacaa taacttccag

acgtttcccc aggcggtgct gctgctcttc aggtgtgcaa caggtgaggc ctggcaggag

atcatgctgg cctgtctccc agggaagctc tgtgaccctg agtcagatta caaccccggg

gaggagcata catgtgggag caactttgcc attgtctatt tcatcagttt ttacatgctc

tgtgcatttc tgatcatcaa tctgtttgtg gctgtcatca tggataattt cgactatctg

acccgggact ggtctatttt ggggcctcac catttagatg aattcaaaag aatatggtca

gaatatgacc ctgaggcaaa gggaaggata aaacaccttg atgtggtcac tctgcttcga

cgcatccagc ctcccctggg gtttgggaag ttatgtccac acagggtagc gtgcaagaga

ttagttgcca tgaacatgcc tctcaacagt gacgggacag tcatgtttaa tgcaaccctg

tttgctttgg ttcgaacggc tcttaagatc aagaccgaag ggaacctgga gcaagctaat

gaagaacttc gggctgtgat aaagaaaatt tggaagaaaa ccagcatgaa attacttgac

caagttgtcc ctccagctgg tgatgatgag gtaaccgtgg ggaagttcta tgccactttc

ctgatacagg actactttag gaaattcaag aaacggaaag aacaaggact ggtgggaaag

taccctgcga agaacaccac aattgcccta caggcgggat taaggacact gcatgacatt

gggccagaaa tccggcgtgc tatatcgtgt gatttgcaag atgacgagcc tgaggaaaca

aaacgagaag aagaagatga tgtgttcaaa agaaatggtg ccctgcttgg aaaccatgtc

aatcatgtta atagtgatag gagagattcc cttcagcaga ccaataccac ccaccgtccc

ctgcatgtcc aaaggccttc aattccacct gcaagtgata ctgagaaacc gctgtttcct

ccagcaggaa attcggtgtg tcataaccat cataaccata attccatagg aaagcaagtt

cccacctcaa caaatgccaa tctcaataat gccaatatgt ccaaagctgc ccatggaaag

cggcccagca ttgggaacct tgagcatgtg tctgaaaatg ggcatcattc ttcccacaag

catgaccggg agcctcagag aaggtccagt gtgaaaagaa cccgctatta tgaaacttac

attaggtccg actcaggaga tgaacagctc ccaactattt gccgggaaga cccagagata

catggctatt tcagggaccc ccactgcttg ggggagcagg agtatttcag tagtgaggaa

tgctacgagg atgacagctc gcccacctgg agcaggcaaa actatggcta ctacagcaga

tacccaggca gaaacatcga ctctgagagg ccccgaggct accatcatcc ccaaggattc

ttggaggacg atgactcgcc cgtttgctat gattcacgga gatctccaag gagacgccta

ctacctccca ccccagcatc ccaccggaga tcctccttca actttgagtg cctgcgccgg

cagagcagcc aggaagaggt cccgtcgtct cccatcttcc cccatcgcac ggccctgcct

ctgcatctaa tgcagcaaca gatcatggca gttgccggcc tagattcaag taaagcccag

aagtactcac cgagtcactc gacccggtcg tgggccaccc ctccagcaac ccctccctac

cgggactgga caccgtgcta cacccccctg atccaagtgg agcagtcaga ggccctggac

caggtgaacg gcagcctgcc gtccctgcac cgcagctcct ggtacacaga cgagcccgac

atctcctacc ggactttcac accagccagc ctgactgtcc ccagcagctt ccggaacaaa

aacagcgaca agcagaggag tgcggacagc ttggtggagg cagtcctgat atccgaaggc

ttgggacgct atgcaaggga cccaaaattt gtgtcagcaa caaaacacga aatcgctgat

gcctgtgacc tcaccatcga cgagatggag agtgcagcca gcaccctgct taatgggaac

gtgcgtcccc gagccaacgg ggatgtgggc cccctctcac accggcagga ctatgagcta

caggactttg gtcctggcta cagcgacgaa gagccagacc ctgggaggga tgaggaggac

ctggcggatg aaatgatatg catcaccacc ttgtagcccc cagcgagggg cagactggct

ctggcctcag gtggggcgca ggagagccag gggaaaagtg cctcatagtt aggaaagttt

aggcactagt tgggagtaat attcaattaa ttagactttt gtataagaga tgtcatgcct

caagaaagcc ataaacctgg taggaacagg tcccaagcgg ttgagcctgg cagagtacca

tgcgctcggc cccagctgca ggaaacagca ggccccgccc tctcacagag gatgggtgag

gaggccagac ctgccctgcc ccattgtcca gatgggcact gctgtggagt ctgcttctcc

catgtaccag ggcaccaggc ccacccaact gaaggcatgg cggcggggtg caggggaaag

ttaaaggtga tgacgatcat cacacctgtg tcgttacctc agccatcggt ctagcatatc

agtcactggg cccaacatat ccatttttaa accctttccc ccaaatacac tgcgtcctgg

ttcctgttta gctgttctga aatacggtgt gtaagtaagt cagaacccag ctaccagtga

ttattgcgag ggcaatggga cctcataaat aaggttttct gtgatgtgac gccagtttac

ataagagaat atcac

AF088004

tttttttttt cttacaaaga aaaatttaat attcgatgag aggttgaacc aggcttaaag

cagacatact aggaaatggt gcagcctgta agaatgccag tttgtaagta ctgactttgg

aaaagatcat cgcctctatc agacacttag ggtcctggtc tggcaatttt ggcctgatgt

gatgccacaa gacccaacag agagagacac agagtccagg ataatgttga cagtggtgta

gccctttagg agaaatggcg ctccctgcgg ctggtattag gttaccattg gcaccgaagg

aaccaggagg ataagaatat ccataatttc agagctgccc tggcacagta cctgccccgt

cggaggctct cactggcaaa tgacagctct gtgcaaggag cactcccaag tataaaaatt

attacacagt tttattctga agaacatttt gcattttaat aaaaaaggat ttatgtcagg

aaagagtcat ttacaaacct tgaagtgttt ttgcctggat cagagtaaga atgtcttaag

aagaggtttg taaggtcttc ataacaaagt ggtgtttgtt atttacaaaa aaaaaaaaaa

aaaaaaatta acaggttgtc tgtatactat taaaaat

M83566

agaataaggg cagggaccgc ggctcctatc tcttggtgat ccccttcccc attccgcccc

cgcctcaacg cccagcacag tgccctgcac acagtagtcg ctcaataaat gttcgtggat

gatgatgatg atgatgatga aaaaaatgca gcatcaacgg cagcagcaag cggaccacgc

gaacgaggca aactatgcaa gaggcaccag acttcctctt tctggtgaag gaccaacttc

tcagccgaat agctccaagc aaactgtcct gtcttggcaa gctgcaatcg atgctgctag

acaggccaag gctgcccaaa ctatgagcac ctctgcaccc ccacctgtag gatctctctc

ccaaagaaaa cgtcagcaat acgccaagag caaaaaacag ggtaactcgt ccaacagccg

acctgcccgc gcccttttct gtttatcact caataacccc atccgaagag cctgcattag

tatagtggaa tggaaaccat ttgacatatt tatattattg gctatttttg ccaattgtgt

ggccttagct atttacatcc cattccctga agatgattct aattcaacaa atcataactt

ggaaaaagta gaatatgcct tcctgattat ttttacagtc gagacatttt tgaagattat

agcgtatgga ttattgctac atcctaatgc ttatgttagg aatggatgga atttactgga

ttttgttata gtaatagtag gattgtttag tgtaattttg gaacaattaa ccaaagaaac

agaaggcggg aaccactcaa gcggcaaatc tggaggcttt gatgtcaaag ccctccgtgc

ctttcgagtg ttgcgaccac ttcgactagt gtcaggggtg cccagtttac aagttgtcct

gaactccatt ataaaagcca tggttcccct ccttcacata gcccttttgg tattatttgt

aatcataatc tatgctatta taggattgga actttttatt ggaaaaatgc acaaaacatg

tttttttgct gactcagata tcgtagctga agaggaccca gctccatgtg cgttctcagg

gaatggacgc cagtgtactg ccaatggcac ggaatgtagg agtggctggg ttggcccgaa

cggaggcatc accaactttg ataactttgc ctttgccatg cttactgtgt ttcagtgcat

caccatggag ggctggacag acgtgctcta ctgggtaaat gatgcgatag gatgggaatg

gccatgggtg tattttgtta gtctgatcat ccttggctca tttttcgtcc ttaacctggt

tcttggtgtc cttagtggag aattctcaaa ggaaagagag aaggcaaaag cacggggaga

tttccagaag ctccgggaga agcagcagct ggaggaggat ctaaagggct acttggattg

gatcacccaa gctgaggaca tcgatccgga gaatgaggaa gaaggaggag aggaaggcaa

acgaaatact agcatgccca ccagcgagac tgagtctgtg aacacagaga acgtcagcgg

tgaaggcgag aaccgaggct gctgtggaag tctctggtgc tggtggagac ggagaggcgc

ggccaaggcg gggccctctg ggtgtcggcg gtggggtcaa gccatctcaa aatccaaact

cagccgacgc tggcgtcgct ggaaccgatt caatcgcaga agatgtaggg ccgccgtgaa

gtctgtcacg ttttactggc tggttatcgt cctggtgttt ctgaacacct taaccatttc

ctctgagcac tacaatcagc cagattggtt gacacagatt caagatattg ccaacaaagt

cctcttggct ctgttcacct gcgagatgct ggtaaaaatg tacagcttgg gcctccaagc

atatttcgtc tctcttttca accggtttga ttgcttcgtg gtgtgtggtg gaatcactga

gacgatcctg gtggaactgg aaatcatgtc tcccctgggg atctctgtgt ttcggtgtgt

gcgcctctta agaatcttca aagtgaccag gcactggact tccctgagca acttagtggc

atccttatta aactccatga agtccatcgc ttcgctgttg cttctgcttt ttctcttcat

tatcatcttt tccttgcttg ggatgcagct gtttggcggc aagtttaatt ttgatgaaac

gcaaaccaag cggagcacct ttgacaattt ccctcaagca cttctcacag tgttccagat

cctgacaggc gaagactgga atgctgtgat gtacgatggc atcatggctt acgggggccc

atcctcttca ggaatgatcg tctgcatcta cttcatcatc ctcttcattt gtggtaacta

tattctactg aatgtcttct tggccatcgc tgtagacaat ttggctgatg ctgaaagtct

gaacactgct cagaaagaag aagcggaaga aaaggagagg aaaaagattg ccagaaaaga

gagcctagaa aataaaaaga acaacaaacc agaagtcaac cagatagcca acagtgacaa

caaggttaca attgatgact atagagaaga ggatgaagac aaggacccct atccgccttg

cgatgtgcca gtaggggaag aggaagagga agaggaggag gatgaacctg aggttcctgc

cggaccccgt cctcgaagga tctcggagtt gaacatgaag gaaaaaattg cccccatccc

tgaagggagc gctttcttca ttcttagcaa gaccaacccg atccgcgtag gctgccacaa

gctcatcaac caccacatct tcaccaacct catccttgtc ttcatcatgc tgagcagcgc

tgccctggcc gcagaggacc ccatccgcag ccactccttc cggaacacga tactgggtta

ctttgactat gccttcacag ccatctttac tgttgagatc ctgttgaaga tgacaacttt

tggagctttc ctccacaaag gggccttctg caggaactac ttcaatttgc tggatatgct

ggtggttggg gtgtctctgg tgtcatttgg gattcaatcc agtgccatct ccgttgtgaa

gattctgagg gtcttaaggg tcctgcgtcc cctcagggcc atcaacagag caaaaggact

taagcacgtg gtccagtgcg tcttcgtggc catccggacc atcggcaaca tcatgatcgt

cactaccctc ctgcagttca tgtttgcctg tatcggggtc cagttgttca aggggaagtt

ctatcgctgt acggatgaag ccaaaagtaa ccctgaagaa tgcaggggac ttttcatcct

ctacaaggat ggggatgttg acagtcctgt ggtccgtgaa cggatctggc aaaacagtga

tttcaacttc gacaacgtcc tctctgctat gatggcgctc ttcacagtct ccacgtttga

gggctggcct gcgttgctgt ataaagccat cgactcgaat ggagagaaca tcggcccaat

ctacaaccac cgcgtggaga tctccatctt cttcatcatc tacatcatca ttgtagcttt

cttcatgatg aacatctttg tgggctttgt catcgttaca tttcaggaac aaggagaaaa

agagtataag aactgtgagc tggacaaaaa tcagcgtcag tgtgttgaat acgccttgaa

agcacgtccc ttgcggagat acatccccaa aaacccctac cagtacaagt tctggtacgt

ggtgaactct tcgcctttcg aatacatgat gtttgtcctc atcatgctca acacactctg

cttggccatg cagcactacg agcagtccaa gatgttcaat gatgccatgg acattctgaa

catggtcttc accggggtgt tcaccgtcga gatggttttg aaagtcatcg catttaagcc

taaggggtat tttagtgacg cctggaacac gtttgactcc ctcatcgtaa tcggcagcat

tatagacgtg gccctcagcg aagcggaccc aactgaaagt gaaaatgtcc ctgtcccaac

tgctacacct gggaactctg aagagagcaa tagaatctcc atcacctttt tccgtctttt

ccgagtgatg cgattggtga agcttctcag caggggggaa ggcatccgga cattgctgtg

gacttttatt aagtcctttc aggcgctccc gtatgtggcc ctcctcatag ccatgctgtt

cttcatctat gcggtcattg gcatgcagat gtttgggaaa gttgccatga gagataacaa

ccagatcaat aggaacaata acttccagac gtttccccag gcggtgctgc tgctcttcag

gtgtgcaaca ggtgaggcct ggcaggagat catgctggcc tgtctcccag ggaagctctg

tgaccctgag tcagattaca accccgggga ggagtataca tgtgggagca actttgccat

tgtctatttc atcagttttt acatgctctg tgcatttctg atcatcaatc tgtttgtggc

tgtcatcatg gataatttcg actatctgac ccgggactgg tctattttgg ggcctcacca

tttagatgaa ttcaaaagaa tatggtcaga atatgaccct gaggcaaagg gaaggataaa

acaccttgat gtggtcactc tgcttcgacg catccagcct cccctggggt ttgggaagtt

atgtccacac agggtagcgt gcaagagatt agttgccatg aacatgcctc tcaacagtga

cgggacagtc atgtttaatg caaccctgtt tgctttggtt cgaacggctc ttaagatcaa

gaccgaaggg aacctggagc aagctaatga agaacttcgg gctgtgataa agaaaatttg

gaagaaaacc agcatgaaat tacttgacca agttgtccct ccagctggtg atgatgaggt

aaccgtgggg aagttctatg ccactttcct gatacaggac tactttagga aattcaagaa

acggaaagaa caaggactgg tgggaaagta ccctgcgaag aacaccacaa ttgccctaca

ggcgggatta aggacactgc atgacattgg gccagaaatc cggcgtgcta tatcgtgtga

tttgcaagat gacgagcctg aggaaacaaa acgagaagaa gaagatgatg tgttcaaaag

aaatggtgcc ctgcttggaa accatgtcaa tcatgttaat agtgatagga gagattccct

tcagcagacc aataccaccc accgtcccct gcatgtccaa aggccttcaa ttccacctgc

aagtgatact gagaaaccgc tgtttcctcc agcaggaaat tcggtgtgtc ataaccatca

taaccataat tccataggaa agcaagttcc cacctcaaca aatgccaatc tcaataatgc

caatatgtcc aaagctgccc atggaaagcg gcccagcatt gggaaccttg agcatgtgtc

tgaaaatggg catcattctt cccacaagca tgaccgggag cctcagagaa ggtccagtgt

gaaaagaacc cgctattatg aaacttacat taggtccgac tcaggagatg aacagctccc

aactatttgc cgggaagacc cagagataca tggctatttc agggaccccc actgcttggg

ggagcaggag tatttcagta gtgaggaatg ctacgaggat gacagctcgc ccacctggag

caggcaaaac tatggctact acagcagata cccaggcaga aacatcgact ctgagaggcc

ccgaggctac catcatcccc aaggattctt ggaggacgat gactcgcccg tttgctatga

ttcacggaga tctccaagga gacgcctact acctcccacc ccagcatccc accggagatc

ctccttcaac tttgagtgcc tgcgccggca gagcagccag gaagaggtcc cgtcgtctcc

catcttcccc catcgcacgg ccctgcctct gcatctaatg cagcaacaga tcatggcagt

tgccggccta gattcaagta aagcccagaa gtactcaccg agtcactcga cccggtcgtg

ggccacccct ccagcaaccc ctccctaccg ggactggaca ccgtgctaca cccccctgat

ccaagtggag cagtcagagg ccctggacca ggtgaacggc agcctgccgt ccctgcaccg

cagctcctgg tacacagacg agcccgacat ctcctaccgg actttcacac cagccagcct

gactgtcccc agcagcttcc ggaacaaaaa cagcgacaag cagaggagtg cggacagctt

ggtggaggca gtcctgatat ccgaaggctt gggacgctat gcaagggacc caaaatttgt

gtcagcaaca aaacacgaaa tcgctgatgc ctgtgacctc accatcgacg agatggagag

tgcagccagc accctgctta atgggaacgt gcgtccccga gccaacgggg atgtgggccc

cctctcacac cggcaggact atgagctaca ggactttggt cctggctaca gcgacgaaga

gccagaccct gggagggatg aggaggacct ggcggatgaa atgatatgca tcaccacctt

gtagccccca gcgaggggca gactggctct ggcctcaggt ggggcgcagg agagccaggg

gaaaagtgcc tcatagttag gaaagtttag gcactagttg ggagtaatat tcaattaatt

agacttttgt ataagagatg tcatgcctca agaaagccat aaacctggta ggaacaggtc

ccaagcggtt gagcctggca gagtaccatg cgctcggccc cagctgcagg aaacagcagg

ccccgccctc tcacagagga tgggtgagga ggccagacct gccctgcccc attgtccaga

tgggcactgc tgtggagtct gcttctccca tgtaccaggg caccaggccc acccaactga

aggcatggcg gcggggtgca ggggaaagtt aaaggtgatg acgatcatca cacctcgtgt

cgttacctca gccatcggtc tagcatatca gtcactgggc ccaacatatc catttttaaa

ccctttcccc caaatacact gcgtcctggt tcctgtttag ctgttctgaa ata

CB410657

GTACTGTGCCGGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTG

CCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACT

GTCAACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGC

CAAAATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCAAAGTCAG

TAC

BQ372430

TGCAGCAANTGGCACGGAATGTAGGAGTGGGTGGGTGGGACCGAACGGAGGCATCACCAA

CTTTGATAACTTGGCCTATGCCATGCTTACGGTGTTTCAGTGCATCACCATGGAGGGCTG

GACAGATGTGCTCTACTGGGTAAATGATGCGATAGGATGGGAATGGCCATGGGCGTATTT

TGTTAGTCTGATCATCCTTGGCTCATTTTTCGTCCTTAACCTGGTTCTTGGTGTCCTTAG

TGGAGAATTCTCAAAGGAAAGAGAGAAGGCAAAAGCACGGGGAGATTTCCAGAAGCTCCG

GGAGAAGCAGCAGCTGGAGGAGGATCTAAAGGGCTACTTGG

BQ366601

ATGACTACGGGGGAAGTTCATTCTGACCTTCCAGACTAGCTAGTACTATATGAAATCCGA

GAGACGGAATGAACACGGACTGATGGGAAAGTACCCTGCGAAGAACACCACAATTGCCCT

ACAGGCGTGATTAAGGACACTGCATGATAGTTGCTCCAGAATGCCGGCGTGCTATATCGT

GTGATTTGCAAGATGACGAGCGTGAGGAAACAAAACGAGAAGAAGAAGATGATGTGTTCA

AAAGAAATGGTGCCCTGCTTGGAAACCATGTCAATCATGTTAATAGTGATAGGAGAGATT

CCCTTCAGCAGACCAATACCACCCACCGTCCNCTGCATGTCCAAAGGCCTTCAATTCCAC

CTGCAAGTGATACTGAGAAACCGCTGTTCCTCCAGCAGGAAATTCG

BQ324528

TACATCTCCGCTATCTGTGCCGTGTAACACGGTGTCCAGTCTCGTTAGGGAGGGGCTGCT

GGAGGGGTGGCCCACGACCGGGTCGAGTGACTCGGTGAGCACTTCTGTGCTTTACTTGAA

TCTAGGCCGGCAACTGCCATGATCTGTTGCTGCATTAGATGCAGAGGCAGTGCCGCGCGA

TGGTGAAGATGGGAGACGACGGGACCTCTTGCTGGCTGCTCTGCCGGCGCAGGCAC

BQ318830

TGTCGTGACTGGCGATACCTGGCGTTAGTGTGTACATGGTGTTCATAATTGCTGCTGCAT

AACATTTTGTGAGAATTAATGTGACAATGTATGTGCAGTGCTTAGCACATAGCAAGTGCT

CATGAATGGTAGCCACCAAGATGGCTGTTGTCATTTTAGTTTGCAGCAGTTCCACTTGTC

ATCATTGAGTTCCCAGGGAGTCCCCTCTTCTTTGGGAACAGACTTGCTCTCTGTAGCTCC

ATTGCGGTAAAAACAGATGAGGTTAATCCCTGTCCCAATCATTTTGGAGATGGCGTCGTT

TGTATTCCAATTCCACAGCCCAGTTCTTGTCTTTGTCTTCCTTTTATTTAAGCAGCAGCC

ACACAGAATTAGCCCTTTTCAAAAATAAATAAGATTATCATCCTGTTTTGCGTCCCTGGG

GTAACAGACTCTAACATTTCTTTCTCTTTCTCTTCTTTCAGATTGTCTAGTGTAATTTTG

GAACAATTAACCAAAGAAACAGAAGGCGGGAACCACTCACGCGGCAAATCTGGAGGCTTT

GATGTCAAAGCCCTCCGTGCCTTTCGAGTGTTGCGACCACTTCGAA

AL708030

AGTTCCCACCTCAACAAATGCCAATCTCAATAATGCCAATATGTCCAAAGCTGCCCATGG

AAAGCGGCCCAGCATTGGGAACCTTGAGCATGTGTCTGAAAATGGGCATCATTCTTCCCA

CAAGCATGACCGGGAGCCTCAGAGAAGGTCCAGTGTGAAAAGGTCCGACTCAGGAGATGA

ACAGCTCCCAACTATTTGCCGGGAAGACCCAGAGATACATGGCTATTTCAGGGACCCCCA

CTGCTTGGGGGAGCAGGAGTATTTCAGTAGTGAGGAATGCTACGAGGATGACAGCTCGCC

CACCTGGAGCAGGCAAAACTATGGCTACTACAGCAGATACCCAGGCAGAAACATCGACTC

TGAGAGGCCCCGAGGCTACCATCATCCCCAAGGATTCTTGGAGGACGATGACTCGCCCGT

TTGCTATGATTCACGGAGATCTCCAAGGAGACGCCTACTACCTCCCACCCCAGCATGTGA

GGCCAGATTTTTTGTTTTTGGGTGGAACCTCCCGGGGAACAGTGTACCTTTCCCCCAACC

CCCGCTCTG

BM509161

ATTCGGCACGAGCCTCCTTCAACTTTGAGTGCTCTGCCCCTTGGGTATCCATAGTTACGG

TTTTCTCTGTGGCCCACCCAGGGTGTTTTTTGCATCGCTGGTGCAGAAATGCACAGGTGG

ATGAGATATAGCTGCTCTTGTCCTCTGGGGACTGGTGGTGCTGCTTAAGAAATAAGGGGT

GCTGGGGACAGAGGAGCAACGTGGTGATCTATAGGATTGGAGTGTCGGGGTCTGTACAAA

TCGTATTGTTGCCTTTTACAAAACTGCTGTACTGTATGTTCTCTTTGAGGGCTTTTATAT

GCAATTGACTGAGGGCTGAAGTTTTCATTAGAATGCACTCACACTCTGACTGTACGTCCT

GATGAAAACCCACTTTTGGATAATTAGAACCGTCAAGGCTTCATTTTCTGTCAACAGAAT

TAGGCCGACTGTCAGGTTACCTTGGCAGGGATTCCCTGCAATCAAAAAGATAGATGATAG

GTAGCAATTTTGGTCCAAAATTTTTAATAGTATACAGACAACCTGTTAATTTTTTTTTTT

TTTTTTTTTGTAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTT

N85902

GGAAAACTCAAGTCCAGAGCAATACTACGTAAAATTCAGAAGTGAGAACATACAAAGGCA

ACACACAGGCTGACGAAGAAACAGAAAGAAGATACTGACCTGAGTTTGGATTTTGAGATG

GCTTGACTGAAAGAAAGACAAAAAGTGTTAAGATTCTGGTTCCGAGGGCTTGAGCACACA

CTCCCCATCATTTCAGCTGGAGATTTCAT

BQ774355

TTTTTTTTTTTTTTTTTTATTCTGAAGAACATTTTGCATTTTAATAAAAAAGGATTTATG

TCAGGAAAGAGTCATTTACAAACCTTGAAGTGTTTTTGCCTGGATCAGAGTAAGAATGTC

TTAAGAAGAGGTTTGTAAGGTCTTCATAACAAAGTGGTGTTTGTTATTTACAAAAAAAAA

AAAAAAAAATTAACAGGTTGTCTGTATACTATTAAAAATTTTGGACCAAAATTGCTACCT

ATCATCTATCTTTTTGATTGCAGGGAATCCCTGCCAAGGTAACTTGACAGTCGGCCTAAT

TCTGTTGACAGAAAATGAAGCCTTGACGGTTCTAATTATCCAAAAGTGGGTTTTCATCAG

GACGTACAGTCAGAGTGTGAGTGCATTCTAATGAAAACTTCTTCAGCCCTCATTCAATTG

CATACAAAAGCCCTCAAAGAGAACATACAGTACAGCAGTTTTGTAAAAGGCAACAATACG

ATTTGTACAGACCCCGACACTCCAATCCTATAGATCACCACGTTGCTCCTCTGTCCCCAG

CACCCCTTATTTCTTAAGCAGCACCACCAGTCCCCAGAGGACAAGAGCAGCTATATCTCA

TCCACCTGTGCATTTCTGCACCAGCGATGCANAAAACACCCTGGGGTGGGCCACAGAGAA

AACCGTAACTATGGATACCCAAGGGGC

CA774243

TAAATAACAAACACCACTTTGTTATGAAGACCTTACAAACCTCTTCTTAAGACATTCTTA

CTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTCTTTCCTGACATAAATCCT

TTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGTAATAATTTTTATACTTGG

GAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCTCCGACGGGGCAGGTACTG

TGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTGGTTCCTTCGGTGCCAATG

GTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAGGGCTACACCACTGTCAAC

ATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGCATCACATCAGGCCAAAAT

TGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCTTTTCCAAAGTCAGTACTT

ACAAACTGGCATTCTTACAGGCTGCACCATTTCCTAGTATGTCTGCTTTAAGCCTGGTTC

AACCTCTCATCGAATATTAAATTTTTCTTTGTA

CA436347

TTTTTTTTTTTTTTTCTTGGGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAAA

AAAATTTCTGTAGGGTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGC

TGAATAAATGAAAATTGGCTCTATTTCTTCAACTTCGGGATAGCCCGAGTAAAAATACTA

ATAATTTCTAAATTTTAGGGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGT

TCAAATACAATACAGTAATTACAAAATATAGACCATCTCTTTACAAATACAAATTATAGT

ATATTACAAGTCATGTACAGTAAATCTATAATTTTAAACAAACTAGTGTATCTAAGTTTA

CCTGGTTGCGAGTGCATTATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAA

CCGACCATCGGAGTGATATTCTCTTATGTAAAC

CA389011

TGATTACTTGTAGCAAAGTACTTCCCCACATTTAGCTGGATTTGTCTTTGGTTTGAAGAG

GCTAATACGTGAAAGATTTGTTCACAGTTGGATGTCCCCTTTTCTGAACCATGAAGTAAT

ATTGTGAATGGAGTTGAATGCTGAGGTTAGGGTGCCGGAAAGATTCAGGGTCCTTCGGTA

CCCTCACATGGCTTGGCTTTGGTAGAACAAGAAACTAAGCTCTGATTTGGCTTTAAATGA

GAGTGCTAAATTTCCTTTTTCTAATAAAGAACCTAGCTAAACATTTATATATACTTTTGA

ACACTGAACTNTCTTGTTGCAGAGTTAACAGCTGTTGGGGGTAGCTGACAGCTGGATCCT

GGTGCTGTTGGTACCATGGTACCTGAAGTGCACAGGCTGGTAGCCACACCTGACA

BU679327

TTTTTTTTTTTTTTTCTTACAAAGAAAAATTTAATATTCGATNGAGAGGTTGAACCAGGC

TTAAAGCAGACATACTAGGAAATGGTGCAGCCTGTAAGAATGCCAGTTTGTAAGTACTGA

CTTTGGAAAAGATCATCGCCTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCC

TGATGTGATGCCACAAGACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACAGT

GGTGTAGCCCTTTAGGAGAAATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTGGCAC

CGAAGGAACCAGGAGGATAAGAATATCCATAATTTCAGAGCTGCCCTGGCACAGTACCTG

CCCCGTCGGAGGCTCTCACTGGCAAATGACAGCTCTGTGCAAGGAGCACTCCCAAGTATA

AAAATTATTACACAGTTTTATTCTGAAGAACATTTTGCATTTTAATAAAAAAGGATTTAT

GTCAGGAAAGAGTCATTTACAAACCTTGAAGTGTTTTTGCCTGGATCAGAGTAAGAATGT

CTTAAGAAGAGGTTTGTAAGGTCTTCATAACANAGTGGTGTTTGTTATTTACAAAAAAAA

AAAAAAAAAAAATAAAAAAAAAAAAAAAAACCTCGTGCCGAATTCT

BU608029

TTTTTTTTTTTTTTTTGTAAATAACAAACACCACTTTGGTTATGAAGACCTTACAAACCT

CTTCTTAAGACATTCTTACTCTGATCCAGGCAAAAACACTTCAAGGTTTGTAAATGACTC

TTTCCTGACATAAATCCTTTTTTATTAAAATGCAAAATGTTCTTCAGAATAAAACTGTGT

AATAATTTTTATACTTGGGAGTGCTCCTTGCACAGAGCTGTCATTTGCCAGTGAGAGCCT

CCGACAGGGCAGGTACTGTGCCAGGGCAGCTCTGAAATTATGGATATTCTTATCCTCCTG

GTTCCTTCGGTGCCAATGGTAACCTAATACCAGCCGCAGGGAGCGCCATTTCTCCTAAAG

GGCTACACCACTGTCAACATTATCCTGGACTCTGTGTCTCTCTCTGTTGGGTCTTGTGGC

ATCACATCAGGCCAAAATTGCCAGACCAGGACCCTAAGTGTCTGATAGAGGCGATGATCT

TTTCCAAAGTCAGTACTTACAAACTGGCATTCTTACAGGCTGCACCATTTCCTAGTATGT

CTGCTTTAAGCCTGGTTCAACCTCTCATCGAATATTAAATTTTTCTTTGTAAGAAAAATT

TGAAGTTGTAGAGCATGGTTTTTTGTTTTCCCTTGTCTTAGGAAAGTTTTAAGATGAAAT

GTTTTTCC

BUO73743

AGTACACAAGGTGAAACTGCTCCAGTTTTTCTCATAGCAGGGTCAGCAGGAAAGCAAGTG

GTGCCCCTGGTCCCATCTCACACAGGTGAGACTGCACCGAGAGGTAACGTGGCCCTCACA

GCCCACCACGCCTGGCCTTCGCCCAATTCTGAAACTTCGTAGGATAGAGCTGGAAAGTGC

CACATGGTGAAGCGAGATCCAGCTGTCTGGGTGGATGTCGGAGTCCATAGGCTGAGCAGA

GATGGTTCTTAGTGAGGTTCTCGCTGCCAGTTGACGGTGAAATCATAGCTGCCATTTACA

TTTTGTGAGATTATGAAAAACATAAGACTAAAGAAACTAAATGTGTTATTCCTGTGGACA

CAAAAATGTGTGTTTTTCAGATGGGGAGGGGACCAAAAAGGAAAAACATTTCATCTTAAA

ACTTCCCTAAGACAAAGGAAAACAAAAAACCATGCTCTACAACTTCAAATTTTTCTTACA

AAGAAAAATTTAATAT

BE175413

AGCTGAGGAAACAAAACGAGAGAAGAAGATGATGTGTTCAAAAGAAATGGTGCCCTGCTT

GGAAACCATGTCAATCATGTTAATAGTGATAGGAGAGATTCCCTTCAGCAGACCAATACC

ACCCACCGTCCCCTGCATGTCCAAAGGCCTTCAATTCCACCTGCAAGTGATACTGAGAAA

CCGCTGTTTCCTCCAGCAGGAAATTCGGTGTGTCATAACCATCATAACCATAATTCCATA

GGAAAGCAAGTTCCCACCTCAACAAATGCCAATCTCAATAATGCCAATATGTCCAAAGCT

GCCCATGGAAAGCGGCCCAGCATAGGGAACCTTGAGCATGTGTCTGAAAATGGGCATCAT

TCTTCCCACAAGCATGACCGGGAGCCTCAGAGAAGGTCCAGTGTGAAAAGGTCCGACTCA

GGAGATGAACAGCTCCCAACTATTGGCCGGGAAGACCCAGAGATACATGGCTATTTCAGG

CACCCCCACGGCTTGGGGGAGCAGGAGTATTTCAGTAGTGAGGAATGCTACGAGGATGAC

AGCTCGCCCACCTGGAGCAGGCAAAACTATGGCTACTACAGCAGATACCCAGGCAGAAAC

ATCGACTCTGAGAGGCGCGAGGCTACATCATCCCAAGATTCTGGAGGAGATGACTCGCCG

TTTGTATGATCACGAGATCTCAAGAGAGCTATACTCCCACC

AW969248

TCTTGTGGAAAGATGATAGGTTTATAGTGACTCAAAATATTTTAGAAAAATTTCTGTAGG

GTCAAGTTCTTTCAAACTTAAAATTTTAACCCCAGAGGATTTTCGCTGAATAAATGAAAA

TTGGCTCTATTTCTTCTACTTCTGGATAGCCCGAGTAAAAATACTAATAATTTCTAGATT

TTAGTGGGGAACTACAATTATTAGGACCCATGGATATTGCTGCAGTTCAAATACAATACA

GTAATTACAAAATATAGACCATCTCTTTACAAATCCAAATTATAGTATATTACAAGTCAT

GTACCGTAAATCTATTTTAAACAAACTAGGGTATCTAAGTTTACCTGGTTGCAAGTGCAT

TATTATTCCAGTTTACAGTTGCCCTTAGCGTGACAGTCAGAAACCGACCATCGGAGTGAT

ATTCTCTTATGTAAACTGGCGTCACATCACAGAAAACCTTATTTATTTGGGGGAAAGGGT

TTAAAAATGGATATGTTGGGCCCAGTGACTGATAC

AI90811

GGAAAAGATCATCGCCTCTATCAGACACTTAGGGTCCTGGTCTGGCAATTTTGGCCTGAT

GTGATGCCACAAGACCCAACAGAGAGAGACACAGAGTCCAGGATAATGTTGACAGTGGTG

TAGCCCTTTAGGAGAAATGGCGCTCCCTGCGGCTGGTATTAGGTTACCATTGGCACCGAA

GGAACCAGGAGGATAAGAATATCCATAATTTCAGAGCTGCCCTGGCACGGTACCTGCCCC

GTCGGAGGCTCTCACTGG

BF754485

GATGCGTGATGGCTGATCTAGAGGTATCCCATGGACTCTCATCGCAGCTCCTGGTACACA

GACGAGCCCGACATCTCCTACCGGACTTTCACACCAGCCAGCCTGACTGTCCCCAGCAGC

TTCCGGAACAAAAACAGCGACAAGCAGAGGAGTGCGGACAGCTTGGTGGAGGCAGTCCTG

ATATCCGAAGGCTTGGGACGCTATGCAAGGGACCCAAAATTTGTGTCAGCAACAAAACAC

GAGATCGCTGATGCCTGTGACCTCACCATCGACGAGATGGAGAGTGCAGCCAGCACCCTG

CTTAATGGGAACGTGCGTCCCCGAGCCAACGGGGATGTGGGCCCCCTCTCACACCGGCAG

GACTATGAGCTACAGGACTTTGGTCCTGGCTACAGCGACGAAGGGCCAGACCCTGGGAGG

GATGAGGAGGACCTGGCGGATGAAATGATATGCATCACCACCTTGTAGCCCCCAGCGAGG

GGCAGACTGGCTCTGGCCTCAGGTGGGGCG

BI015409

CGCTCGTTCGCTGTGCCAGGACAAAGTCCTGTAGCTCATAGTCCTGCCGTGTGAGAGGGG

GCCACATCCCCGTTNCTCGGGACGCACGACCCATTAAGCAGGGTGCTGGCTGCCCCCTCC

ATCTCGTCGATGGAGAGGTCANCAGGCATCAGCGATTTCGTGTTTTGTGTGCGTGACACA

AATTTTGGGTCCCTTGCATACGCGTCCCACAGCCTTACGGAGTATCAGCGACTGCTCTCC

ACCAATGCTGCCCGCGACTCCTACTGCTTGTCCGCTGTTTTTGGTTCCGGAAGCTGCTGG

GGACAGTCAGGCTGGCTGGTGTGAAAGTCCGGTAGGAGATGTCGGGCTCGTCTGTGTACC

AGGAGCTGCGGTGCAGGGACGGCAGGCTGCCGTTCACCTGGTCCG

BG202552

GAGTTTCGAGCTTCTCTTTTCCTAAGNGAAAAAANAAAGAANCACAAGNAAACCAAATAA

CCATGTTACTCTGTATAAAAATGCTAATCAGGGAATTCTGAATCAATAATGCTCCAATGA

AGGACAGAATTTAATTAGAAACAACACTAACCACAAGAGCCTAGCACAACCCAAACTCAG

AGCTTCCTGGTAATCTCAATGCGATGGATTCATTACACAGACCATCTTATTAAAATTCTC

ATCTGAGAGCTAATCAGCATTGAATGCATCATTTATTTTATGACACCAAAATTAACTGCA

GTGATTCTTTAAGCATGGGGACACGTGACTCCCACTCTCAGCCCCGAGGGATGACAGCCA

AGAGCCTGGCTTCTGCCCAAGATTCCATCCGTTTTGGTCTGCAGTGCATGGTCAACCATG

ATCCACAAAGCAGCAACCCGGGGGCTGTAGCTGCCGTGATGCGGGGGTAAGCCTGGCAGG

CTGCAACTGTTGCAGGGCTCCCAACACAGCCCCTGGACAAACGCGTCAGGGGAAAATAGG

GTTACCTGGCAATCTTTTTCCTCTCCTTTTCTTCCGCTTCTTCTTTCTGAGCAGTGTTCA

GACTTTCAGCATCAGCCAAAGTGTCTACAGCGATGGCCAAGAAGACATTCAGTAGAATAT

CTAATTACAACTTTTTAAGGGCACAACACACTACTAAATGCAACTACGTGCGGCCAACAA

TGGCAACGCCACACACCTCTGCATCCCGGGAAGCTGGGTAGTAGGTGACGTCCCCAAGTG

TTATACTCACACAGCAAACCTAGAGTACCAGAGCCCTGCTTTTCAAACAANACANAACAA

ACAAACAACCCAAAGTAAAACCTGGTAAGGGACGTCTTCAGAAGTAAATTAC

BF883669

CTGGCTTTCCCATAGCACGCTCGGCAGGAAAGCAAGTGATGCCCCTGGCTCCCATCTCAC

ACAGGTGACACTGCACCGAGAGGTAACGTGGCCCTCACAGCCCACCACGCCTGGCCTTCG

CCCAATTCTGAAACTTCGTAGGATAGAGCTGGAAAGTGGCACATGGTGAAGCGAGATCCA

GCTGTCTGGGTGGATGTCGGAGCTCCATAGGCTGAGCAGAGATGGTTCTTAGTGAGGTTC

TCGCTGCCAGTTGACGGTGAAATCATAGCTGCCATTTACATTTTGTGAGATTATGAAAAA

CATAAGACTAAAGAAACTAAATGTGTTATTCCTGTGGACACAAAAATGTGTGTTTTTCAG

ATGGGGAGGGGACCAAAAAGGAAAAACATTTCATCTTAAAACTTTCCTAAGACAAAGGAA

AACAA

BF817590

CTCAGCATGNATGAAACAGGATGAGGTTGGTGAAGATGTGGTGGTTGATGAGCTTGTGGC

AGCCTACGCGGATCGGGTTGGTCTTGCTAAGAATGAAGAAAGCGCTCCCTTCAGGGATGG

GGGCAATTTTTTCCTTCATGTTCAACTCCGAGATCCTTCGAGGACGGGGTCCGGCAGGAA

CCTCAGGTTCATCCTCCTCCTCTTCCTCTTCCTCTTCCCCTACGGGCACATCGCAAGGCG

GATAGGGGTCCTTGTCTTCATCCTCTTCTCTATAGTCATCAATTGTAACCTTGTTGTCAC

TGTTGGCTATCTGGTTGACTTCTGGTTTGTTGTTCTTTTTATTTTCTAGGCTCTCTTTTC

TGGCAATCTTTTTCCTCTCCTTTTCTTCCGCTTCTTCTTTCTGAGCAGTGTTCAGACTTT

CAGCATCAGCCAAATGGTCTA

BF807128

TCAAAGTCGAAGGAGGATCTCCGCGTGGGATGCTGGGGTGGGAGGTAGTAGGCGTCTCCT

TGGAGATCTCCGTGAATCATAGCAAACGGGCGAGTCATCGTCCTACAAGAATCCTAGTGG

ATGATGGTAGCCTCGGGGCCTCTCAGAGTCGATGTTTCTGCCTGG

BF806160

CTCGCCCGTTTGCTATGAGTCACGGAGATCTCCAAGGAGACGCCTACTACCTCCCACCCC

AGCATCCCACCGGAGATCCTCCTTCAACTTTGAGTGCCTGCGCCGGCAGAGCAGCCAGGA

AGAGGTCCCGTCGTCTCCCATCTTCCCCCATCGCACGGCCCTGCCTCTGCATCTAATGCA

GCAACAGATCATGGCAGTTGCCGGCCTAGATTCAAGTAAAGCCCAGAAGTACTCACCGAG

TCACTCGACCCGGCCGTGGGCCACCCCTCCAGCAACCCCTCCCTACCGGGACTGGACACC

GTGCTACACCCCCCAGATGACGCCGATGTA

BF805244

CCAGGCAGAAACATCGACTCTGAGAdGCCCCGAGGCTACCATCATCCCCAAGGATTCTTG

GAGGACGATGACTCGCCCGTTTGCTATGATTCACGGAGATCTCCAAGGAGACGCCTACTA

CCTCCCACCCCAGCATCCCACCGGAGATCCTCCTTCAACTTTGAGTGCCTGCGCCGGCAG

AGCAGCCAGGAAGAGGTCCCGTCGTCTCCCATCTTCCCCCATCGCACGGCCCTGCCTCTG

CATCTAATGCAGCAACAGATCATGGCAGTTGCCGGCCTAGATTCAAGTAAAGCCCAGAAG

TACTCACCGAGTCACTCGACCCGGTCGTGGGCCACCCCTCCAGCAACCCCTCCCTACCGG

GACTGGACACCGTGCTACACCCCCCAGATGACGCCGATGTA

BF805235

TACATCGGCGTCATCTGGGGGGTGTAGCACGGTGTCCAGTCCCGGTAGGGAGGGGTTGCT

GGAGGGGTGGCCCACGACCGGGTCGAGTGACTCGGTGAGTACTTCTGGGCTTTACTTGAA

TCTAGGCCGGCAACTGCCATGATCTGTTGCTGCATTAGATGCAGAGGCAGGGCCGTGCGA

TGGGGGAAGATGGGAGACGACGGGACCTCTTCCTGGCTGCTCTGCCGGCGCAGGCACTCA

AAGTTGAAGGAGGATCTCCGGTGGGATGCTGGGGTGGGAGGTAGTAGGCGTCTCCTTGGA

GATCTCCGTGAATCATAGCANACGGGCGAGTCATCGTCCTCCAAGAATCCTTGNNGATGA

TGGTAGCCTCGGNGCCTCTCAGAGTCGATGTTTCTGCCTGNGTATCTGCTCGGGCGAGCC

GGTACCGAGCT

BF805080

TACATCGGCGTCATCTGGGGGGTGTAGCACGGTGTCCAGTCCCGGTAGGGAGGGGTTGCT

GGAGGGGTGGCCCACGACCGGGTCGAGTGACTCGGTGAGTACTTCTGGGCTTTACTTGAA

TCTAGGCCGGCAACTGCCATGATCTGTTGCTGCATTAGATGCAGAGGCAGGGCCGTGCGA

TGGGGGAAGATGGGAGACGACGGGACCTCTTCCTGGCTGCTCTGCCGGCGCAGGCACTCA

AAGTTGAAGGAGGATCTCCGGTGGGATGCTGGGGTGGGAGGTAGTAGGCGTCTCCTTGGA

GATCTCCGTGAATCATAGCAAACGGGCGAG

T27949

GCGGACAGCTTGGTGGAGGCAGTCCTGATATCCGAAGCCTTNGGACGCTATGCAAGGGAC

CCAAAATTTNTTTCAGCAACAAAACACGAAATCGCTGATGCCTGTAACCTCACCATCGAC

GAGATGGAGAGTNCAGCCAGCACCCTGCTTAATGGGAACGTGCGTCCCCGAGCCAACGGG

GAT

BE836638

AAGAAATAGGAGGATAAGAATATCATATTTCAGAGCTGCCCTGGCACAGTACCTGCCCCG

TCGGAGGCTCTCACTGGCAAATGACAGCTCTGTGCAAGGAGCACTCCCAAGTATAAAAAT

TATTACACAGTT

BE770685

CCATTGGTACGAGAGAAATTAGGAGGATAAGATTATCTATTATTCTGAGCTGCCCTGGCA

CAGTACCTGCCCCGTCGGAGGCTCTCACTGGCAAATGACAGCTCTGTGCAAGGAGCACTC

CCAAGTATAAAAATTATTACATAGTTTTATTCTGAAGAACATTTTGCATTTTAATAAAAA

AGGATTTATGTCAGGAAAGAGTCATTTACATACCTTGAATTGTTTTTGCCTGGATCAGAG

TAAGAATGTCTTAAGAAGAGGTTTGTAAGGTCTTCATAACAAAGTGGTGTTTGTTATTTA

CAAAAAAAAAAAAAAAAA.AAATTTTTATACCGGGTTTGTCTGTATACAAATTTCTCTG

BE769065

TCCAGAGTAGAAGAAATCAGCCAAGTATCATTTATTCAGCGAAAATCCTCTGGGGATTAA

AATTTTAAGTTTGAAAGAACTTGACACTACAGAAATTTTTCTAAAATATTTTGAGTCACT

ATAAACCTATCATCTTTCCACAAGATATACCAGATGACTATTTGCAGTCTTTTCTTTGGG

CAAGAGTTCCATGATTTTGATACTGTACCTTTGGATCCACCATGGGTTGCAACTGTCTTT

GGTTTTGTTTGTTTGACTTGAACCACCCTCTGGAAAGCTACTCTGGAAA

Sequences identified as those of HOXB13 cluster

BF676461

GGGATTCCCCCGGCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCATAGATTCCCCTGCCCG

AACCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGAAATTATGCCACCTTGGATGGAG

CCAAGGATATCGAAGGCTTGTTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCC

TCTCTGACCAGCCACCCAGCGCGCTACGCTTGATGCCTGTGTCAATATGCCCCCTTGATC

TGCCAGGCTCGGGGAGCGGCCAAAAGCAATGCCCACCCTATGCTCTGGGGGTGCCCAGGG

GACTGTCCCCGGCTCCGTGCCTTATGGTTACTGTGGGGCGGGGTACATACTCCTGCAGAG

TTGTCCCGGAGCTCGTTGAAACCTTGTGCCGAGGAGAGCCACCCTGGCGGTACCCGGGAA

GACTCCCCAGGGCGGGAAGAGTACCCCAGCGGCCCAATGAGTTGTGCTTCTATCGGGATA

TCCGGGACCTACCAGGCCTATGTGCAGGTACTGGACGTGTCCTGTGCTGCAGACTCTGGG

TGTCCGTGGAGCACCGGACATTGGCTCGCTGTGGCCTGTGGCCGGTACCAGTCTTGGGCT

CTCGGTGTGTGGCTGGACACGCCGGTTGTGTTCGCGGGAGACCGCACCCACCAGGTTCCT

TTGGGAGGGCCGCTTTGCAGACTCCGGGGGAGGCCCCTCTGAGGCGGGGCCTTTTCGGGG

GGGCGAAGAAAGCTTTCCGACGCAGGCGCTTGCGGAGCTGGCGGGACATCGGGACACTTC

ACCCAGCGAAGCGCGGCTTGGGGCCCCTCTGGGCGCGGTCTCGGTTGACACCGGCGAAGA

GTTTCGGGAGAGGCCCATATCTTCTGGGGAGGGCGTTGCGTCGCCCCCG

BC007092

ggattccccc ggcctgggtg gggagagcga gctgggtgcc ccctagattc cccgcccccg

cacctcatga gccgaccctc ggctccatgg agcccggcaa ttatgccacc ttggatggag

ccaaggatat cgaaggcttg ctgggagcgg gaggggggcg gaatctggtc gcccactccc

ctctgaccag ccacccagcg gcgcctacgc tgatgcctgc tgtcaactat gcccccttgg

atctgccagg ctcggcggag ccgccaaagc aatgccaccc atgccctggg gtgccccagg

ggacgtcccc agctcccgtg ccttatggtt actttggagg cgggtactac tcctgccgag

tgtcccggag ctcgctgaaa ccctgtgccc aggcagccac cctggccgcg taccccgcgg

agactcccac ggccggggaa gagtacccca gccgccccac tgagtttgcc ttctatccgg

gatatccggg aacctaccag cctatggcca gttacctgga cgtgtctgtg gtgcagactc

tgggtgctcc tggagaaccg cgacatgact ccctgttgcc tgtggacagt taccagtctt

gggctctcgc tggtggctgg aacagccaga tgtgttgcca gggagaacag aacccaccag

gtcccttttg gaaggcagca tttgcagact ccagcgggca gcaccctcct gacgcctgcg

cctttcgtcg cggccgcaag aaacgcattc cgtacagcaa ggggcagttg cgggagctgg

agcgggagta tgcggctaac aagttcatca ccaaggacaa gaggcgcaag atctcggcag

ccaccagcct ctcggagcgc cagattacca tctggtttca gaaccgccgg gtcaaagaga

agaaggttct cgccaaggtg aagaacagcg ctacccctta agagatctcc ttgcctgggt

gggaggagcg aaagtggggg tgtcctgggg agaccaggaa cctgccaagc ccaggctggg

gccaaggact ctgctgagag gcccctagag acaacaccct tcccaggcca ctggctgctg

gactgttcct caggagcggc ctgggtaccc agtatgtgca gggagacgga accccatgtg

acagcccact ccaccagggt tcccaaagaa cctggcccag tcataatcat tcatcctgac

agtggcaata atcacgataa ccagtactag ctgccatgat cgttagcctc atattttcta

tctagagctc tgtagagcac tttagaaacc gctttcatga attgagctaa ttatgaataa

atttggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

BM462617

ATTCCCCCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCA

CCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCC

AAGGATATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCT

CTGACCAGCCACCCAGCGGCGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGAT

CTGCCAGGCTCGGCGGAGCCGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGG

ACGTCCCCAGCTCCCGTGCCTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTG

TCCCGGAGCTCGCTGAAACCCTGTGCCCAGGCAGCCACCCTGGCCGCGTACCCCGCGGAG

ACTCCCACGGCCGGGGAAGAGTACCCCAGCCGCCCCACTGAGTTTGCCTTCTATCCGGGA

TATCCGGGAACCTACCAGCCTATGGCCAGTTACCTGGACGTGTCTGTGGTGCAGACTCTG

GGTGCTCCTGGAGAACCGCGACATGACTCCCTGTTGCCTGTGGACAGTTACCAGTCCTGG

GCTCTCGCTGGTGGCTGGAACAGCCAGATGTGTTGCCAGGGAGAACAGAACCCACCAGGT

CCCCTTTTGGAAGGCAGCATTTGCAGACTCCAGCGGGCAGCACCCTCCTGACGCCTGCGC

CTTTCGT

BG752489

GCAGGCGACTTGCGAGCTGGGAGCGATTTAAAACGCTTTGGATTCCCCCGGCCTGGGTGG

GGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCCTCG

GCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCTTGC

TGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGCGG

CGCCTACGCTGATGCCTGCTGTCAACTATCCCCCCTTGGATCTGCCAGGCTCGGCGGAGC

CGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGGACGTCCCCAGCTCCCGTGC

CTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTGTCCCGGAGCTCGCTGAAAC

CCTGTGCCCAGGCAGCCACCCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAAG

AGTACCCCAGCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACCAGC

CTATGGCCAGTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACCGC

GACATGACTCCCTGTTGCCTGTGGACAGTTACCAGTCTTGGGCTCTCGCTGGTGGCTGGA

ACAGCCAGATGTGTTGCCAGGGAGAACAGAAGCCACCAGGTCCCTTTTGGAAGGCAGCAT

CTGCAGACTCCAGCGGGCAGGACCTCCTGACGCCTGCGGCCTTTCGTCGCGAGCGCAAGA

AACGCATTCCGTA

BG778198

GGATTTAAAACGCTTTGGATTCCCCCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCT

AGATTCCCCGCCCCCGCACCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGCAATTAT

GCCACCTTGGATGGAGCCAAGGATATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAAT

CTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGCGGCGCCTACGCTGATGCCTGCTGTC

AACTATGCCCCCTTGGATCTGCCAGGCTCGGCGGAGCCGCCAAAGCAATGCCACCCATGC

CCTGGGGTGCCCCAGGGACGTCCCCAGCTCCCGTGCCTTATGGTTACTTTGGAGGCGGGT

ACTACTCCTGCCGAGTGTCCCGGAGCTCGCTGAAACCCTGTGCCCAGGCAGCCACCCTGG

CCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAAGAGTACCCCAGCCGCCCCACTGAGT

TTGCCTTCTATCCGGGATATCCGGGAACCTACCAGCCTATGGCCAGTTACCTGGACGTGT

CTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACCGCGACATGACTCCCTGTTGCCTGTGG

ACAGTTACCAGTCTTGGGCTCTCGCTGGTGGGCTGGAACAGCCAGATGTGTTGCCAGCGC

AGAACAGAACCCACCAGGTCCCTTTTGGAAGGCAGCATTTGCAGACTCCAGCGGGCAGAA

CCCTCCTGACGCCTGCGCCTTTCGTTCGCGGGCGAAAAA

CB050884

AAGAAACGCATTCCGTACAGCAAGGGGCAGTTGCGGGAGCTGGAGCGGGAGTATGCGGCT

AACAAGTTCATCACCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGCCTCTCGGAG

CGCCAGATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGAAGGTTCTCGCCAAG

GTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAGCGAAAGTGG

GGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGGGGCCAAGGACTCTGCTGA

GAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTCCTCAGGAGC

GGCCTGGGTACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCACTCCACCAG

GGTTCCCAAAGAACCTGGCCCAGTCATAATCATTCATCCTGACAGTGGCAATAATCACGA

TAACCAGTACTAGCTGCCATGATCGTTAGCCTCATATTTTCTATCTAGAGCTCTGTAGAG

CACTTTAGAAACCGCTTTCATGAATTGAGCTAATTATGAATAAATTTGGAAGGCGAAAAA

AAAAACCTCGTGCC

CB050885

ATTCGGCACGAGGTTTTTTTTTTCGCCTTCCAAATTTATTCATAATTAGCTCAATTCATG

AAAGCGGTTTCTAAAGTGCTCTACAGAGCTCTAGATAGAAAATATGAGGCTAACGATCAT

GGCAGCTAGTACTGGTTATCGTGATTATTGCCACTGTCAGGATGAATGATTATGACTGGG

CCAGGTTCTTTGGGAACCCTGGTGGAGTGGGCTGTCACATGGGGTTCCGTCTCCCTGCAC

ATACTGGGTACCCAGGCCGCTCCTGAGGAACAGTCCAGCAACCAGTGGCCTGGGAAGGGT

GTTGTCTCTAGGGGCCTC

BF965191

GGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGA

CCCTCGGCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAG

GCTTGCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACC

CAGCGGCGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTCGG

CGGAGCCGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGGACGTCCCCAGCTC

CCGTGCCTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTGTCCCGGAGCTCGC

TGAAACCCTGTGCCAGGCAGCCACCCTGGCCGCGTAACCCGACGGAGACTCTCACGTGCG

GGGAAGAGTACCCCTAGCGCCCCACATGAGTTTGCCTTCTATCCGGGATATCCGGGACCG

TACCAGCCTATGGCAGTTACCTGGACGTGTCTGTGGTGCCGACTCTGGGTGCTCCTGGAG

AACCGCGGACATGACTCCTTGTTTGCTGTGCGACGCTCACCAGTCTGGGCTCCTCGTCGG

TGGTCGCACTCCCACTTTTTGCCGGGCGACATCCCCCGGGGCCCCTTCCGGAACAGCGAC

CTTGCGAGCCCCCGGGGACACACCCCCGTAAGCGGCCTATCATCGCTGATAAACCTCATC

AGAGGGCACCGAAAGCCGCGACTCTAACCCCCCCACTACGACTCACGACCGCACAGGTAC

TCGAACCGCCCAATATCTGGTTCTAACCCATGGCGCATCTCAGCCGCTAGAGAGCCAACC

AAACGCGCCACGCGCAACCACACTACACCACGGCACCCCTTTCATCTCACTCCCACGCCG

ATCACTCTTCACCCTCCAGAATCATTCCCCTCGCACATCCTACCTATCTCATGCCTCCCA

GTTCACCCCATTCCCTCCCCTAATCTCACCCACACATTCACGCACGTTCTCACTACGCTT

CGCTCCGACCCACATCCTCACCCCCACATTCATACCACTTCACCATCACGACCCCCCCCT

CTCATCGACTCCTGTCTCATTCTCAACCACAGTACTACCAGCTCCAACACACCACTCACC

CCAAGCTATCCATCACCTACACGCTTTCACCCCTCACCGCTCCCAAGTAATTCAGATCAC

TCAAACACAATCTGCTACATACTCATCCCTCCCCCACTCCCAGTACAGTCCAACCACCGA

CCAACTACCTCCGCGCCACCCGCGCCGCCCCACCTCACCGGCCCCAACCGCCCGCACAGG

GCACGCACCCCCCGGCAACCGCGCGATCCGGCCGTACACACTCTTGGGCGGCACGCAGCT

GAGGACATTCCGCGGGAGCGCCCCACCGTGGGCTACGTGGGTCGCGACCCGGCGGGGCGC

GTGCGGCGTCGCCCGCCCGCCCGCCGACTGCGACCCAGTCGAG

BU930208

GGGGCTTTGGATTCCCCCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCC

CGCCCCCGCACCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGCAATTATGCCACCTT

GGATGGAGCCAAGGATATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGC

CCACTCCCCTCTGACCAGCCACCCAGCGGCGCCTACGCTGATGCCTGCTGTCAACTATGC

CCCCTTGGATCTGCCAGGCTCGGCGGAGCCGCCAAAGCAATGCCACCCATGCCCTGGGGT

GCCCCAGGGGACGTCCCCAGCTCCCGTGCCTTATGGTTACTTTGGAGGCGGGTACTACTC

CTGCCGAGTGTCCCGGAGCTCGCTGAAACCCTGTGCCCAGGCAGCCACCCTGGCCGCGTA

CCCCGCGGAGACTCCCACGGCCGGGGAAGAGTACCCCAGCCGCCCCACTGAGTTTGCCTT

CTATCCGGGATATCCGGGAACCTACCAGCCTATGGCCAGTTACCTGGACGTGTCTGTGGT

GCAGACTCTGGGTGCTCCTGNAGAACCGCGACATGACTCCCTGTTGCCTGTGGACAGTTA

CCAGTCTTGGGCTCTCGCTGGTGGCCTGGAACAGCCCAGATGTGTTTGCCCAGGGNAGAA

CACGAACCCCACCCGGTTCCCCCTTTTGGGAAAGGGCAGCCATTTTGGCCAGCCTTCCAA

GCGGGGCCAACCACCCCCTCCCCTGGACAGGCCCTGGT

AA807966

GCGGCCGCAAGAAACGCATTCCGTACAGCAAGGGGCAGTTGCGGGACTGGAGCGGGAGTA

TGCGGCTAACAAGTTCATCACCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGCCT

CTCGGAGCGCCAGATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGAAGGTTCT

CGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAGCG

AAAGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGGGGCCAAGGACT

CTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTCCT

CAGGAGCGGCCTGGGTACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCATT

CCACCAGGGTTCCCAAAGAACCTGGCCCAGTCATAATCATTCATCCTGACAGTGGC

AI884491

AGCGGCCGCAAGAAACGCATTCCGTACAGCAAGGGGCAGTTGCGGGAGCTGGAGCGGGAG

TATGCGGCTAACAAGTTCATCACCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGC

CTCTCGGAGCGCCAGATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGAAGGTT

CTCGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAG

CGAAAGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGGGGCCAAGGA

CTCTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTC

CTCAGGAGCGGCCTGGGTACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCA

CTCCACCAGGGTTCCCAAAGAACCTGGCCCAGTCATAATCATTCATCCTGACAGTGGCAA

TAATCACGATAACCAGTACTAGCTGCCATGATCGTTAGCCTCATATTTTCTATCTAGAGC

TCTGTAGAGCAC

AA652388

GCGGCCGCAAGAAACGCATTCCGTACAGCAAGGGGCAGTTGCGGGACTGGAGCGTGAGTA

TGCGGCTAACAA9TTCATCACCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGCCT

CTCGGAGCGCCAGATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGAAGGTTCT

CGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAGCG

AAAGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGGGGCCAAGGACT

CTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTCCT

CAGGAGCGGCCTGGGTACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCACT

CCACCAGGGTTCCCAAAGAACCTGGCC

BF446158

TTTTTTTTTTTTTTTTTTTCGCCTTCCAAATTTATTCATAATTAGCTCAATTCATGAAAG

CGGTTTCTAAAGTGCTCTACAAAGCTCTAAATAAAAAATATGAGGCTAACGATCATGGCA

GCTAGTACTGGTTATCGGGATTATTGCCACTGTCAGGATGAATGATTATGACTGGGCCAG

GTTCTTTGGGAACCCTGGTGGAGTGGGCTGTCACATGGGGTTCCGTCTCCCTGCACATAC

TGGGTACCCAGGCCGTTCCTGAGGAACAGTCCACCACCCAGTGGCCTGGGAAGGGTGTTG

TCTCTAGGGGCCTCTCAACAAAGTCCTTGGCCCCAGCCTGGGCTTGGCAGGTTCCTGGTC

TCCCCAGGACACCCCCACTTTCGCTCCTCCCACCCAGGCAAGGAGATCTCTTAAGGGG

AA657924

GACGCNAGGTATGCGGCTAACAAGTTCATCACCAAGGACAAGAGGCGCAAGATCTCGGCA

GCCACCAGCCTCTCGGAGCGCCAGATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAG

AAGAAGGTTCTCGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTTGCCTGGG

TGGGAGGAGCGAAAGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGG

GGCCAAGGACTCTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGGCTGCT

GGACTGTTCCTCAGGAGCGGCCTGGGTACCCATGTATGTGCAGGGAGACGGAACCCCATG

TGACAGCCCACTCCACCAGNGTTCCTAAAGAACCCTGGCCAGTCA

AA644637

GCAGGCGACTTGCGAGCTGGGAGCGGTTTAAAACGCTTTGGATTCCCCCGGCCTGGGTGG

GGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCCTCG

GTCCATGGACACGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCTTGCTG

GGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGCGGCG

CCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTCGGCGGACTCT

NAAAGCATATGCCACCCNATGCCCTGGGGTGCCCCAGGGGAACGTCCCCAGCTCCCGTGC

CTTATGGTT

BF222357

GCGGCCGCAAGAAACGCATTCCGTACAGCAAGGGGCAGTTGCGGGAGCTGGAGCGGGAGT

ATGCGGCTAACAAGTTCATCACCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGCC

TCTCGGAGCGCCAGATTACCATCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGAAGGTTC

TCGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAGC

GAAAGTGGGGGTGTCCTGGGGAGACCAG6AACCTGCCAAGCCCAGGCTGGGGCCAAGGAC

TCTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTCC

TCAGGAGCGGCCTG

AA527613

GTCGACGAACAGCGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAGCGAAAGTG

GGGGTGTCCTGGGGAGACCGGGAACTGCCAAGCCCAGGCTGGGGCAAGGACTCTGCTGAG

AGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGCTGCTGGACTGTTCCTCAGGAGCGG

CCTGGGTACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCACTCCACCAGGG

TTCCCAAAGAACCTGGCCCAGTCATAATCATTCATCCTGACAGTGGCAATAATCACGATA

ACCAGTACTCAGCTGCCATGATCGTTAGCCTCATATT

AA533227

GCGTCGACCCCTTGAAGAGATCTCCTTGCCTGGGTGGGAGGAGCGAAAGTGGGGGTGTCC

TGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGGGGCCAAGGACTCTGCTGAGAGGCCCC

TAGAGACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTCCTCAGGAGCGGCCTGGG

TACCCAGTATGTGCAGGGAGACGGAACCCCATGTGACAGCCCACTCCACCAGGGTTCCCA

AAGAACCTGGCCCAGTCATAATCATTCATCCTGACAGTGGCAATAATCACGATAACCAGT

ACTAGCTGCCATGATCGTTAGCCTCATATTTTCTATCTAGAGCTCTGTAGAGCACTTGTA

GAAACCGCTTTCATGAATTGAGCTAATTATGAATAGATTTGGAAGGGGAAAAAAGTGGAA

AAAGTTTTGCCCAAAGTGGGTCGTTTACGTCG

AA456069

CTCCCTGGCAACACATCTGGCTGTTCCAGCACCAGCGAGACCCAAGACTGGTAACTGTCC

ACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACAGAC

ACGTCCAGGTAACTGGCCATAGCTGAGTAGGTTCCCGGATATCCCGGATAGAAGGCAAAC

TCAGTGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGAGAGTCTCCGCGGGGTACGGCCC

AGGGTGGCTGCCTGGGCATCAGGGTTTCAGCGAGCTCCGGGACACTCGGCAGGAGTAGTA

CCCGCCTCCAAAGTAACCATAAGGCACGGGAGCTGGGGACGTCCCTGGGGCACCCCAG

AA455572

TTTAAAACGCTTTGGATTCCCCCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGA

TTCCCCGCCCCCGCACCTCATGAGCCGACCCTCGGTCCATGGAGCCGGCGAATTATGCCA

CCTTGGATGGAGCCAAGGATATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAATCTGG

TCGCCCACTCCCCTCTGACCAGCCACCCAGCGGCGCTACGTGATGCCTGCTGTCAACTAT

GCCCTTGGATCTGCCAGCTCGCGGAGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCC

AGGTGACGTCCCCAGCTCCCGTGCCTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCC

GAGTGTCCCGGAGCTCGCTGAAACCCTGTGCCCAGGCAGCCACCCTGGCCGCGTACCCCG

CGATGACTCCCACGGCCGGGGAAGAGTACCCCAGCCGCCCCACTGAGTTTGCCT

BX117624

CAGGCGACTTGCGAGTCTGGGAGCGATTTAAAACGCTTTGGATTCCCCCGGCCTGGGTGG

GGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCCTCG

GCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCTTGC

TGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGCGG

CGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTCGGCGGAGC

CGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGGACGTCCCCAGCTCCCGTGC

CTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTGTCCCGGAGCTCGCTGAAAC

CCTGTGCCCAGGCAGCCACCCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAAG

AGTACCCCAGCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACCAGC

CTATGGCCAGTTACCTTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACCG

CGACATGACTCCCTGNTGCCTGTGGACAGTTACCAGTCTTGGGCTCTCGCTGGTGGCTGG

AACAGCCAGATGTGTTGNCAGGGAGAACAGAACCCACCAGGTCCCTTTTGGAAGGCAGAT

TTGCAGACTNCAGCGGGCA

BQ673782

AGGCAGCCACCCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAAGAGTACCCCA

GCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACCAGCCTATGGCCA

GTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACCGCGACATGACT

CCCTGTTGCCTGTGGACAGTTACCAGTCTTGGGCTCTCGCTGGTGGCTGGAACAGCCAGA

TGTGTTGCCAGGGAGAACAGAACCCACCAGGTCCCTTTTGGAAGGCAGCATTTGCAGACT

CCAGCGGGCAGCACCCTCCTGACGCCTGCGCCTTTCGTCGCGGCCGCAAGAAACGCATTC

CGTACAGCAAGGGGCAGTTGCGGGAGCTGGAGCGGGAGTATGCGGCTAACAAGTTCATCA

CCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGCCTCTCGGAGCGCCAGATTACCA

TCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGAAGGTTCTCGCCAAGGTGAAGAACAGCG

CTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAGCGAAAGTGGGGGTGTCCTGGGG

AGACCAGGAACCTGCCAAGCCCCAGGCTGGGGCCAAGGACTCTGCTGAGAGGCCCCTAGA

GACAACACCCTTCCCAGGCCACTGGCTGCTGGACTGTTCCTCAGGAGCGGCCTGAGTACC

CCGTATGTGCAGGGGAGACGGAACCCCCTGTGACCAGCCCCCCTCCACCCGTGGTCTCCC

AGATAACCTGGCCCCCACTCATAAATCATTTCTTCCCGGGCCGGGGGCCAATCATTCCCC

GAACTACCCCGGTACCTTATACAATTAGATTGGACATGAATCCTCTCGGGGGCATTCCCT

ATGGCGCTGAGGCCCCTCACACCT

AI814453

GGGTGCTGTCCTCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGGGTTCTGT

TCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGAGCCCAAGACTGGTAACTG

TCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACA

GACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCCCGGATATCCCGGATAGAAGGCA

AACTCAATGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCGCGGGGTACGCG

GCCAGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACACTCGGCAGGAGTAG

TACCCGCCTCCAAAGTAACCATAAGGCACGGGAGCTGGGGACGTCCCCTGGGGCACCCCA

NGGCATGGGTGGCATTGCTTTGGCGGCTCCGCCGAGCCTGGCAGATCCAAGGGGGCATAG

TTGACAGCAGGCATCAGCGTAGGCGCCGCTGGGTGGCTGGTCAAAAGGGAGTGGCGACCA

NATTCCGCCCCCCTCCCGCTTCCCAG

AI417272

GGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGGGTTCTGT

TCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGAGCCCAGGACTGGTAACTG

TCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACA

GACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCCCGGATATCCCGGATAGAAGGCA

AACTCAGTGGGGCGGCTGGGGTACTCTTCCCCGCCGTGGGAGTCTCCGCGGGGTACGCGG

CCAGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACACTCGGCAGGAGTAGT

ACCCGCCTCCAAAGTAACCATAAGGCACGGGAGCTGGGGACGTCCCCTGGGGCACCCCAG

GGCATGGGTGGCATTGCTTTGGCGGCTCCGCCGAGCCTGGCAGATCCAAGGNGGCATAGT

TGACAGCAGGCATCAGCGTANGCGCCGCTGGGTGGCTGTCAAGAGG

AA535663

TCGACGTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACCGCGACA

TGACTCCCTGTTGCCTGTGGACAGTTACCAGTCTTGGGCTCTCGCTGGTGGCTGGAACAG

CAGATGTGTTGCCAGGGAGAACAGAACCCACCAGGTCCCTTTTGGAAGGCAGCATTTGCA

GACTCCAGCGGGCAGCACCCTCCTGACGCCTGCGCCTTTCGTCGCGGCCGCAAGAAACGC

ATTCCGTACAGCAAGGGGCAGTTGCGGGACTGGAGCGGGAGTATGCGGCTAACAAGTTCA

TCACCAAGGACAAGAGGCGCAAGATCTCGGCAGCCACCAGCCTCTCGGAGCGCCAGATTA

CCATCTGGTTTCAGAACCGCCGGGTCAAAGAGAAGAAGGTTCTCGCCAAGGTGAAGAACA

GCGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGGAGGAGCGAAAGTGTG

AI400493

GTCAGGAGGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGG

GTTCTGTTCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGAGCCCAGGACTG

GTAACTGTCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTG

CACCACAGACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCCCGGATATCCCGGATA

GAAGGCAAACTCAGTGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCGCGGG

GTACGCGGCCAGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACACTCGGCA

TGAGTAGACCCGCCTTCCAAGTAACCATAAGGCACGGGAGCTGGTAACGTCCCCTGGGGC

ACCCCANGGCCATGGGTGCATTGCTTTGGCGGCTCCGCCGAGCCCTGCAGATCCAAGGTG

GGCATATTGACAGCAGGCATTCACGTATGCGCCCCCTGGGTGGCTGTCATATTGGGGATT

GCGAC

AW779219

GCAGGCGTCAGGAGGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACC

TGGTGGGTTCTGTTCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGAGCCCA

AGACTGGTAACTGTCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAG

AGTCTGCACCACAGACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCCCGGATATCC

CGGATAGAAGGCAAACTCAGTGGGGCGACTGGGGTACTCTTCCCGGCCGTGGGGAGTCTC

CGCGGGGTACGCGGCCAGGGGTGGCTGCCTGGGCACCAGGGGTTTCAGCGAGCTCCGGGA

CACTCNGCAGGAAANTAGTACCCGCCTCCCAAAGTAACCATAAGCACCGGACTGNGGGNN

GGACGTCCCCTGGGGCAC

AA594847

GCGACCGGACGAAAGGAGGCGTCAGGAGGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCC

TTCCAAAAGGGACCTGGTGGGTTCTGTTCTCCCTGGCAACACATCTGGCTGTTCCAGCAC

CAGCGAGACCCAAGACTGGTAACTGTCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCC

AGGAGCACCCAGAGTCTGCACCACAGACACGTCCAGGTAACTGGCCATAGCTAGGTAGGT

TCCCGGATATCCCGGATAGAAGGCAAACTCAGTGGGGCGACTGGGGTACTCTTCCCCGGC

CGTGGGAGTCTCCGCGGGGTACGCCCATGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAG

CTCCGGGACA

AI150430

GCAGGCGTCAGGAGGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACC

TGGTGGGTTCTGTTCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGAGCCCA

AGACTGGTAACTGTCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAG

AGTCTGCACCACAGACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCCCGGATATCC

CGGATAGAAGGCAAACTCAGTGGGGCGACTGGGGTACTCTTCCCCGGCCGTGGGAGTCTC

CGCGGGGTACGCGGCCAGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACAC

TCGGCAGGAGTAGTACCCGCCTCCAAAGTAACCATAAGGCACGGGAGCTGGATGCGTCCC

CTAGGGCACCCCATGGCATGGGTGGCATTGCTTTGGCGGCTCCGCCGAGCCTGGCAGATC

CAAGGAGGCACTGTT

AA494387

GGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGGGTTCTGT

TCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGACCCAAGACTGGTAACTGT

CCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACAG

ACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCCCGGATATCCCGGATAGAAGGCAA

ACTCAGTGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCGCGGGGTACGCGT

CCAGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACACTCGGCAGGAGTAGT

ACCCGCCTCCAAAGTAACCATAAGGCACGGGAGCTGGGGACGTCCCTG

AA662643

GGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGGGTTCTGT

TCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGACCCAAGACTGGTAACTGT

CCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACAG

ACACGTCCAGGTAACTGGCCATAGGTGGTAGGTTCCCGGATATCCCGGATAGAAGGCAAA

CTCAGTGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCGCGGGGTACGCGGC

CAGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACA

AI935940

GGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGGGTTCTGT

TCTCCCTGGCAACACATCTGGCTGTTCCTGCCACCAGCGAGAGCCCAAGACTGGTAACTG

TCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACA

GACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCCCGGATATCCCGGATAGAAGGCA

AACTCAGTGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCGCGGGGTACGCG

GCCAGGGTGGCTGCCTGGGCACAGGGTTTCAGCG

AA532530

GGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGGGTTCTGT

TCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGCGAGACCCAAGACTGGTAACTGT

CCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACAG

ACACGTCCAGGTAACTGGCCATAGGTNGGTAGGTTCCCGGATATCCCGGATAGAAGGCAA

ACTCAGTGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCG

AA857572

CTCCCTGGCAACACATCTGGCTGTTCCAGCACCAGCGAGAGCCAAGACTGGTAACTGTCC

ACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACAGAC

ACGTCCAGGTAACTGGCCATAGGTCGGTAGGTTCCCGGATATCCCGGATAGAAGGCAAAC

TCAGTGGGGCGACTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCGCGGGGTACGGCNAC

AGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACACTCGGCAGGAGTAGTAN

CCGCCTCAAAGTAACCATAANGCACGGGAGCTGGGGACGTCCC

AI261980

ACGAAAGGCGCAGGCGTCAGGAGGGTGCTGCCCGCTGGAGTCTGCAAATGCTGCCTTCCA

AAAGGGACCTGGTGGGTTCTGTTCTCCCTGGCAACACATCTGGCTGTTCCAGCCACCAGC

GAGAGCCCAAGACTGGTAACTGTCCACAGGCAACAGGGAGTCATGTCGCGGTTCTCCAGG

AGCACCCAGAGTCTGCACCACAGACACGTCCAGGTAACTGGCCATAGGCTGGTAGGTTCC

CGGATATCCCGGATAGAAGGCAAACTCAGTGGGGCGACTGGGGTACTCTTCCCCGGCCCG

GGGAGTCTCCGCGGGGTACGCGGCCAGGGTGGCTGCCTGGGCACAGGGTTTCAGCGAGCT

CCGGGACACTCGGCGGAGNTAGTACCCGCCTCCAAAGTAACCATAAGGCACGGGAGCTGG

GGAACCGTCCCCTGGGGCACC

BE888751.1

GAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCCTCGGCT

CCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCTTGCTGG

GAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGCGGCGC

CTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTCGGCGGAGCCGC

CAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGACGTCCCCAGCTCCCGTGCCTTA

TGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTGTCCCGGAGCTCGCTGAAACCCTG

TGCCCAGGCAGCCACCCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAAGAGTA

CCCCAGCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACCAGCCTAT

GGCCAGTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACCGCGACA

TGACTCCCTGTTGCCTGTGGACAGTTACCAGTCTTGGGCTCTCGCTGGTGGCTGGAACAG

CCAGATGTGTTGCCAGGGAGAACAGAACCCACCAGGTCCCTTTTTGGAAGGCAGCATTTG

CAGACTCCAGCGGCAGGACCTCCTGAACGCCTGCGCCTTTCGTCGCGGCGTCTAAAGTAA

TCCTCGAGG

AI378797

GCGGCCGCGGCCCACCACCAACTGCTCGCCACCGACCCCACTACTCGCCACCGACCCGCT

GCTCGGAGCTTCGGTTCTGCGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCGTGGAG

AATGCGCCGGCAGGCCCCCCACCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCCG

CTGGCTTTGCTGCGCGGCCAGGAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGAC

ATCAGAGAATGAACACAGAGGCAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCA

NAGAGCCCGTCTGTCTCCAGCTTCCAGAATTCCGCACTGTGAATCTGTCTACGTGGACTG

GGAAAACAGGGTTGGCACCACTCTGCCACTCCGTTTGTGCCTGGGAAGGGCTAAGTATGC

AAGGCTACAAACATCTACTTCACTGGGATCCCAAATGCTCAACAAACCATGACCTGCTNT

GGTCAGAACCACCAGAAATATT

AA234220

GCAGGCGACTTGCGAGCTGGGAGCACTTTAAAACGCTTTGGATTCCCCCGGCCTGGGTGG

GGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCCTCG

GCTCCATGGAGCCTGGCATATTATGCCACCTTGGTATGGAGCCAAGGATATCGAAGGCTT

GCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGC

GGCGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGA

AA236353

GCCCGCTGGAGTCTGCAAATGCTGCCTTCCAAAAGGGACCTGGTGGGTTCTGTTCTCCCT

GGCAACACATCTGGCTGTTCCAGCCACCAGCGAGACGCCAAGACTGGTAACTGTCCACAG

GCAACAGGGAGTCATGTCGCGGTTCTCCAGGAGCACCCAGAGTCTGCACCACAGACACGT

CCAGGTAACTGGCCATAGGTNGGTAGGTTCCCGGATATCCCGGATAGAAGGCAAACTCAG

TGGGGCGGCTGGGGTACTCTTCCCCGGCCGTGGGAGTCTCCGCGGGGTACGCGCACAGGG

TGGCTGCCTGGGCACAGGGTTTCAGCGAGCTCCGGGACACTCGGCAGGAGTAGTACCCGC

CTCCAAAGTAACCATAAGGCA

AA588193

AACTGCTCGCCACCGACCCCACTACTCGCCACCGACCCGCTGCTCGGAGCTTCGGTTCTG

CGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCGTGGAGAATGCGCCGGCAGCCCCCA

CCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCCGCTGGCTTTGCTGCGCGGCCAG

GAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGACATCAGAGAATGAACACAGAGG

CAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCAAAGAGCCCGTCTGTCTCCAGC

TTCCAGAATTCCGCACTGTGAATCTGTCTACGTGGACTGGGAAAACAGGGTTGGCACCAC

TCTGCCACTCCGTTTGTGCCTGGGAAGGGCTAAGTATGCAAGGCT

AI821103

GATCCCTTTGCAGGGAAGCTTTCTCTCAGACCCCCTTCCATTACACCTCTCACCCTGGTA

ACAGCAGGAAGACTGAGGAGAGGGGAACGGGCAGATTCGTTGTGTGGCTGTGATGTCCGT

TTAGCATTTTTCTCAGCTGACAGCTGGGTAGGTGGACAATTGTAGAGGCTGTCTCTTCCT

CCCTCCTTGTCCACCCCATAGGGTGTACCCACTGGTCTTGGAAGCACCCATCCTTAATAC

GATGATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTAGTCAGTCCTTCCTT

CCAGAGAAAAAGAGATTTGAGAAAGTGA

AI821851

TTTTTTTTTTTTTTTTTTTTCTTTTTCACTTTCTCAAATCTCTTTTTCTCTGGAAGGAAG

GACTGACTAGGGGCAGCCTGCTGGCTTCATTTTCACACGACAAAAAAATCATCGTATTAA

GGATGGGTGCTTCCAAAACCAGTGGGTACACCCTATGGGGGGGACAAGGAGGGAGGAAGA

GACAGCCTCTACAATTGTCCACCTACCCAGCTGTCAGCTGAGAAAAATGCTAAACGGACA

TCACAGCCACACAACGAATCTGCCCGTTCCCCTCTCCTCAGTCTTCCTGCTGTTACCAGG

GTGAGAGGTGTAATGGAAGG

AA635855

TTTTTTTTTTTTTTTTTTTTCTTTTTCACTTTCCCAAATCTCTTTTTCTCTGGAAGGAAG

GACTGACTAGGGGCAGCCTGCTGGCTTCATTTTCACACGACAGAAAAATCATCGTATTAA

GGATGGGTGCTTCCAAGACCAGTGGGTACACCCTATGGGGTGGACACAGGAGGGAGGAAG

AGACAGCCTCTACAATTGTCCACCTACCCAGCTGTCAGCTGAGAAAAATGCTAAACGGAC

ATCACAGCCACACAACGAATCTGCCCGTTCCCCTCTCCTCAGTCTTCCTGCTGTTACCAG

GGTGAGAGGTGTAATGGAAGG

AI420753

GCGGCCGCGGCCCACCACCAACTGCTCGCCACCGACCCCACTACTCGCCACCGACCCGCT

GCTCGGAGCTTCGGTTCTGCGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCTTGGAG

AATGCGCCGGCAGGCCCCCCACCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCCG

CTGGCTTTGCTGCGCGGCCAGGAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGAC

ATCAGAGAATGAACACAGAGGCAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCA

AAGAGCCCGTCTGTCTCCAGCTTCCAGAATTCCGCACTGTGAATCTGTCTACGT

BG180547

CACGCGTCGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGTCCTTCCCAGGC

ACAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCAC

AGTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAG

GGACATGAGGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGC

CCGGTGGGACTCATCTCCTGGCCGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCT

GCACCTTAGGCTGGGGGTGGGGGGCCTGCCGGCGCATTCTCCACGATTGAGCGCACAGGC

CTGAAGTCTGGACAACCCGCAGAACCGAAGCTCCGAGCAGCGGGTCGGTGGCGAGTAGTG

GGGTCGGTGGCGAGCAGTTGGTGGTGGG

AA468306

TCGACCTCGCCAAGGTGAAGAACAACGCTACCCCTTAAGAGATCTCCTTGCCTGGGTGGG

AGGAGCGAAAGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCCAGGCTGGGGCC

AAGGACTCTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTGGCTGCTGGAC

TGTTCCTCAGGAGCGGCCTGGGTACCCAGTATGTGCAGGGAGA

AA468232

TTTTTTACTGGTTATCGTGGTTATTGCCACTGTCAGGATGAATGATTATGACTGGGCCAG

GTTCTTTGGGAACCCTGGTGGAGTGGGCTGTCACATGGGGTTCCGTCTCCCTGCACATAC

TGGGTACCCAGGCCGCTCCTGAGGAACAGTCCAGCAG

CB050115

GGCCCACCACCAACTGCTCGCCACCGACCCCACTACTCGCCACCGACCCGCTGCTCGGAG

CTTCGGTTCTGCGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCGTGGAGAATGCGCC

GGCAGGCCCCCCACCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCCGCTGGCTTT

GCTGCGCGGCCAGGAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGACATCAGAGA

ATGAACACAGAGGCAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCAAAGAGCCC

GTCTGTCTCCAGCTTCCAGAATTCCGCACTGTGAACCTCGTGCC

CB050116

GGCACGAGGTTCACAGTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGC

CGGGACTCTGAGAGGGACATGAGGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTA

CCTGGGCTCAGTGCCCGGTGGGACTCATCTCCTGGCCGCGCAGCAAAGCCAGCGGGTTCG

TGCTGGTCCTTCCTGCACCTTAGGCTGGGGGTGGGGGGCCTGCCGGCGCATTCTCCACGA

TTGAGCGCACAGGCCTGAAGTCTGGACAACCCGCAGAACCGAAGCTCCGAGCAGCGGGTC

GGTGGCGAGTAGTGGGGTCGGTGGCGAGCAGTTGGTGGTGGGCC

AA661819

GCTGCTCGGAGCTTCGGTTCTGCGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCGTG

GAGAATGCGCCGGCAGCCCCCACCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCC

GCTGGCTTTGCTGCGCGGCCAGGAGATGAGTCCCACCGGCACTGAGCCAGGTACAGGACA

TCAGAGAATGAACACAGAGGCAGAGGCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCAAA

GAGCCGTACTGTCTCCAGCTTCCAGAATTCCGCACTGTGAATCTGTCTACGTGGACTGGG

AAAAC

CF146837

CACGAGGATTTTCTATCTAGAGCTCTGTAGAGCACTTTAGAAACCGCTTTCATGAATTGA

GCTAATTATGAATAAATTTGGAAGGCGATCCCTTTGCAGGGAAGCTTTCTCTCAGACCCC

CTTCCATTACACCTCTCACCCTGGTAACAGCAGGAAGACTGAGGAGAGGGGAACGGGCAG

ATTCGTTGTGTGGCTGTGATGTCCGTTTAGCATTTTTCTCAGCTGACAGCTGGGTAGGTG

GACAATTGTAGAGGCTGTCTCTTCCTCCCTCCTTGTCCACCCCATAGGGTGTACCCACTG

GTCTTGGAAACACCCATCCTTAATACGATGATTTTTCTGTCGTGTGAAAATGAAGCCAGC

AGGCTGCCCCTAGTCAGTCCTTCCTTCCAGAGAAAAAGAGATTTGAGAAAGTGCCTGGGT

AATTCACCATTAATTTCCTCCCCCAAACTCTCTGAGTCTTCCCTTAATATTTCTGGTGGT

TCTGACCAAAGCAGGTCATGGTTTGTTGAGCATTTGGGATCCCAGTGAAGTAGATGTTTG

TAGCCTTGCATACTTAGCCCTTCCCAGGCACAAACGGAGTGGCAGAGTGGTGCCAACCCT

GTTTTCCCAGTCCACGTAGACAGATTCACAGTGCGGAATTCTGGAAGCTGGAGACAGACG

GGCTCTTTGCAGAGCCGGGACTCTGAG

CF146763

CACGAGGATTTTCTATNCTAGAGCTCTGGTAGAGCACTTTANAAACCGCTTTCATGAATT

GAGCTAATTATGAATAAATTTGGAAGGCGATCCCTTTGCAGGGAAGCTTTCTCTCAGACC

CCCTTCCATTACACCTCTCACCCTGGTAACAGCAGGAAGACTGAGGAGAGGGGAACGGGC

AGATTCGTTGTGTGGCTGTGATGTCCGTTTAGCATTTTTCTCAGCTGACAGCTGGGTAGG

TGGACAATTGTAGAGGCTGTCTCTTCCTCCCTCCTTGTCCACCCCATAGGGTGTACCCAC

TGGTCTTGGAAACACCCATCCTTAATACGATGATTTTTCTGTCGTGTGAAAATGAAGCCA

GCAGGCTGCCCCTAGTCAGTCCTTCCTTCCAGAGAAAAAGAGATTGAGAAAGTGCCTGGG

TAATTCACCATTAATTTCCTCCCCCAAACTCTCTGAGTCTTCCCTTAATATTTCTGGTGG

TTCTGACCAAAGCAGGTCATGGTTTGTTGAGCATTTGGGATCCCAGTGAAGTAGATGTTT

GTAGCCTTGCATACTTAGCCCTTCCCAGGCACAAACGGAGTGGCAGAGTGGTGCCAACCC

TGTTTTCCCAGTCCACGTAGACAGATTCACAGTGCGGAATTCTGGAAGCTGGAGACAGAC

GGGCTCTTTGCAGAGCCGGGACTCTGA

CF144902

CACGAGGGAAGCCAGCAGGCTGCCCCTAGTCAGTCCTTCCTTCCAGAGAAAAAGAGATTT

GAGAAAGTGCCTGGGTAATTCACCATTAATTTCCTCCCCCAAACTCTCTGAGTCTTCCCT

TAATATTTCTGGTGGTTCTGACCAAAGCAGGTCATGGTTTGTTGAGCATTTGGGATCCCA

GTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCCCTTCCCAGGCACAAACGGAGTGGCA

GAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCACAGTGCGGAATTCTGG

AAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAGGGACATGAGGGCCTC

TGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGCCCGGTGGGACTCATC

TCCTGGGCGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCTGCACCTTA

CF141511.1

CACGAGGCCTGGTAACAGCAGGAAGACTGAGGAGAGGGGAACGGGCAGATTCGTTGTGTG

GCTGTGATGTCCGTTTAGCATTTTTCTCAGCTGACAGCTGGGTAGGTGGACAATTGTAGA

GGCTGTCTCTTCCTCCCTCCTTGTCCACCCCATAGGGTGTACCCACTGGTCTTGGAAACA

CCCATCCTTAATACGATGATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTA

GTCAGTCCTTCCTTCCAGAGAAAAAGAGATTTGAGAAAGTGCCTGGGTAATTCACCATTA

ATTTCCTCCCCCAAACTCTCTGAGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGC

AGGTCATGGTTTGTTGAGCATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATA

CTTAGCCCTTCCCAGGCACAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTC

CACGTAGACAGATTCACAGTGCGGAATTCTGGAA

CF139563.1

CACGAGGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGCAGGTCATGGTTTGTTGA

GCATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCCCTTCCCAGGC

ACAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCAC

AGTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAG

GGACATGAGGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGC

CCGGTGGGACTCATCTCCTGGCCGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCT

GCACCTTAGGCTGGGGGTGGGGGGCCTGCCGGCGCATTCTCCACGATTGAGCGCACAGGC

CTGAAGTCTGGACAACCCGCAGAACCGAAGCTCCGAGCAGCGGGTCGGTGGCGAGTA

CF139372

CACGAGGATTTCTGGTGGTTCTGACCAAAGCAGGTCATGGTTTGTTGAGCATTTGGGATC

CCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCCCTTCCCAGGCACAAACGGAGTG

GCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCACAGTGCGGAATTC

TGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAGGGACATGAGGGC

CTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGCCCGGTGGGACTC

ATCTCCTGGCCGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCTGCACCTT

CF139319

CACGAGGAAGGCGATCCCTTTGCAGGGAAGCTTTCTCTCAGACCCCCTTCCATTACACCT

CTCACCCTGGTAACAGCAGGAAGACTGAGGAGAGGGGAACGGGCAGATTCGTTGTGTGGC

TGTGATGTCCGTTTAGCATTTTTCTCAGCTGACAGCTGGGTAGGTGGACAATTGTAGAGG

CTGTCTCTTCCTCCCTCCTTGTCCACCCCATAGGGTGTACCCACTGGTCTTGGAAACACC

CATCCTTAATACGATGATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTAGT

CAGTCCTTCCTTCCAGAGAAAAAGAGATTTGAGAAAGTGCCTGGGTAATTCACCATTAAT

TTCCTCCCCCAAACTCTCTGAGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGCAG

GTCATGGTTTGTTGAGCATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACT

TAGCCCTTCC

CF139275

CACGAGGTGGATTCCCCCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCC

CGCCCCCGCACCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGCAATTATGCCACCTT

GGATGGAGCCAAGGATATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGC

CCACTCCCCTCTGAGCAGCCACCCAGCGGCGCCTACGCTGATGCCTGCTGTCAACTATGC

CCCCTTGGATCTGCCAGGCTCGGCGGAGCCGCCAAAGCAATGCCACCCATGCCCTGGGGT

GCCCCAGGGGACGTCCCCAGCTCCCGTGCCTTATGGTTACTTTGGAGGCGGGTACTACTC

CTGCCGAGTGTCGCGGAGCTCGCTGAAACCCTGTGCCCAGGCA

CF122893

CACGAGGATTTTCTATCTAGAGCTCTGTAGAGCACTTTAGAAACCGCTTTCATGAATTGA

GCTAATTATGAATAAATTTGGAAGGCGATCCCTTTGCAGGGAAGCTTTCTCTCAGACCCC

CTTCCATTACACCTCTCACCCTGGTAACAGCAGGAAGACTGAGGAGAGGGGAACGGGCAG

ATTCGTTGTGTGGCTGTGATGTCCGTTTAGCATTTTTCTCAGCTGACAGCTGGGTAGGTG

GACAATTGTAGAGGCTGTCTCTTCCTCCCTCCTTGTCCACCCCATAGGGTGTACCCACTG

GTCTTGGAAACACCCATCCTTAATACGATGATTTTTCTGTCGTGTGAAAATGAAGCCAGC

AGGCTGCCCCTAGTCAGTCCTTCCTTCCAGAGAAAAAGAGATTTGAGAAAGTGCCTGGGT

AATTCACCATTAATTTCCTCCCCCAAACTCTCTGAGTCTTCCCTTAATATTTCTGGTGGT

TCTGACCAAAGCAGGTCATGGTTTGTTGAGCATTTGGGATCCCAGTGAAGTANATGTTTG

TAGCCTTGCATACTTAGCCCTT

AI972423

CATTTTCACACGACTGTAAAATCATCGTATTAAGGATGGGTGCTTCCAAGACCAGTGGGT

ACACCCTATGGGGTGGACAAGGAGGGAGGAAGAGACAGCCTCTACAATTGTCCACCTACC

CAGCTGTCAGCTGAGAAAAATGCTAAACGGACATCACAGCCACACAACGAATCTGCCCGT

TCCCCTCTCCTCAGTCTTCCTGCTGTTACCAGGGTGAGAGGTGTAATGGAAGGGGGTCTG

AGAGAAAGCTTCCCTGCAAAGGGATCGCCTTCCAAATTTATTCATAATTAGCTCAATTCA

TGAAAGCGGTTTCTAAAGTGCTCTACAGAGCTCTAGATAGAAAATATGAGGCTAACGATC

ATGGCAGCTAGTACTGGTTATCGTGATTATTGCCACTGTCAGGATGAATGATTATGACTG

GGCCAGGTTCTTTGGGAACCCTGGTGGAGTGGGCTGTCACATG

AI918975

TGCAGCTAGTACTGGTTATCGTGATTATTGCCACTGTCAGGATGAATGATTATGACTGGG

CCAGGTTCTTTGGGAACCCTGGTGGAGTGGGCTGTCACATGGGGTTCCGTCTCCCTGCAC

ATACTGGGTACCCAGGCCGCTCCTGAGGAACAGTCCAGCACAGGGTTTCAGCGAGCTCCG

GGACACTCGGCCTCGTGC

AI826991

TTTTTTTTTTTTTTTTTTTTCTTTTTCACTTTCTCAAATCTCTTTTTCTCTGGAAGGAAG

GACTGACTAGGGGCAGCCTGCTGGCTTCATTTTCACACCACAAAAAAATCATCGTATTAA

GGATGGGTGCTTCCAAAACCAGTGGGTACACCCTATGGGGTGGACAAGGAGGGAGGAAAA

AACAGCCTCTACAATTGTCCACCTACCCAGCTGTCAGCTGAAAAAAATGCTAAACGGACA

TCACAGCCACACAACGAATCTGCCCGTTCCCCTCTCCTCAGTCTTCCTGCTGTTACCAGG

GTGAAAGGTGTAATGGAAGG

AI686312

ACCGACCCCACTACTTGCCACCGACCCGCTGCTCGGAGCTTCGGTTCTGCGGGTTGTCCA

GACTTCAGGCCTGTGCGCTCAATCGTGGAGAATGCGCCGGCAGGCCCCCCACCCCCAGCC

TAAGGTGCAGGAAGGACCAGCACGAACCCGCTGGCTTTGCTGCGCGGCCAGGAGATGAGT

CCCACCGGGCACTGAGCCCAGGTACAGGACATCAGAGAATGAACACAGAGGCAGAGGCCC

TCATGTCCCTCTCAGAGTCCCGGCTCTGCAAAGAGCCCGTCTGTCTCCAGCTTCCAGAAT

TCCGCACTGTGAATCTGTCTACGTGGACTGGGAAAACAGGGTTGGCACCACTCTGCCACT

CCGTTTGTGCCTGGGAAGGGCTAAGTATGCAAGGCTACAAACATCTACTTCACTGGGATC

C

AI655923

TTTTTTTTTTTTTTTCCCTGCAAAGGGATCGCCTTCCAAATTTATTCATAATTAGCTCAA

TTCATGAAAGCGGTTTCTAAAGTGCTCTACAGAGCTCTAGATAGAAAATATGAGGCTAAC

GATCATGGCAGCTAGTACTGGTTATCGTGATTATTGCCACTGTCAGGATGAATGATTATG

ACTGGGCCAGGTTCTTTGGGAACCCTGGTGGAGTGGGCTGTCACATGGGGTTCCGTCTCC

CTGCACATACTGGGTACCCAGGCCGCTCCTGA

CF146922

CACGAGGCGACTTGCGAGCTGGGAGCGATTTAAAACGCTTTGGATTCCCCGGCCTGGGTG

GGGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCCTC

GGCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCTTG

CTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGCG

GCGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTCGGCGGAG

CCGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGGACGTCCCCAGCTCCCGTG

CCTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTGTCCCGGAGCTCGCTGAAA

CCCTGTGCCCAGGCAGCCACCCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGAA

GAGTACCCCAGCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACCAG

CCTATGGCCAGTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACGC

GACATGACTCCCTGTTGCCTGTGGACAGTTACCAGTCTTGGGCTCTCGCTGGTGGCTGGA

ACAGCCAGATGTGTTGCCA

BF476369

GCGGCCGCGGCCCACCACCAACTGCTCGCCATTCGACCCCACTACTCGCCACCGACCCGC

TGCTCGGAGCTTCGGTTCTGCGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCGTGGA

GAATGCGCCGGCAGGCCCCCCACCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCC

GCTGGCTTTGCTGCGCGGCCAGGAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGA

CATCAGAGAATGAACACAGAGGCAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGC

AAAGAGCCCGTCTGTCTCCAGCTTCCAGAATTCCGCACTGTGAATCTGTCTACGTGGACT

GGGAAAACAGGGTTGGCACCACTCTGCCACTCC

BF057410

GCGGCCGCGGCCCACCACCAACTGCTCGCCACCGACCCCACTACTCGCCACCGACCCGCT

GCTCGGAGCTTCGGTTCTGCGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCGTGGAG

AATGCGCCGGCAGGCCCCCCACCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCCG

CTGGCTTTGCTGCGCGGCCAGGAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGAC

ATCAGAGAATGAACACAGAGGCAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCA

AAGAGCCCGTCTGTCTCCAGCTTCCAGAATTCCGCACTGTGAATCTGTCTACGTGGACTG

GGAAAACAGGGTTGGCACCACTCTGCCACTCCGTTTGTGCCTGGGAAGGGCTAAGTATGC

AAGGCTACAAACATCTACTTCACTGGGATCCCAAATGCTCAACAAACCATGACCTGCTNT

GGTCAGAACCACCAGAAATATTAA

BE645544

GCGGCCGCGGCCCACCACCAACTGCTCGCCACCGACCCCACTACTCGCCACCGACCCGCT

GCTCGGAGCTTCGGTTCTGCGGGTTGTCCAGACTTCAGGCCTGTGCGCTCAATCGTGGAG

AATGCGCCGGCAGGCCCCCCACCCCCAGCCTAAGGTGCAGGAAGGACCAGCACGAACCCG

CTGGCTTTGCTGCGCGGCCAGGAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGAC

ATCAGAGAATGAACACAGAGGCAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCA

AAGAGCCCGTCTGTCTCCAGCTTCCAGAATTCCGCACTGTGAATCTGTCTACGTGGACTG

GGAAAACAGGGTTGGCACCACTCTGCCACTCCGTTTGTGCCTGGGAAGGGCTAAGTATGC

AAGGCTACAAACATCTACTTCACTGGGATCC

BE645408

TCCTCCCTCTAAGAAAGGCGCAAGCGTCAAGAGGGTGCTGCCCGCTGGTTTCTGCAAATG

CTGCCTTCCAAAAAGGACCTGGTGGGTTCTGTTCTCCCTGGCAACACATCTGGCTGTTCC

AGCCACCAGCGAGAGCCCAAGACTGGTAACTGTCCACAGGCAACAGGGAGTCATGTCGCG

GTTCTCCAGGAGCACCCAGAGTCTGCACCACAGACACGT

BE388501

TTAATACGATGATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTAGTCAGTC

CTTCCTTCCAGAGAAAAAGAGATTTGAGAAAGTGCCTGGGTAATTCACCATTAATTTCCT

CCCCCAAACTCTCTGAGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGCAGGTCAT

GGTTTGTTGAGCATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCC

CTTCCCAGGCACAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAG

ACAGATTCACAGTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGG

ACTCTGAGAGGGACATGAGGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTG

GGCTCAGTGdCCGGTGGGACTCATCTCCTGGCCGCGCAGCAAAGCCAGCGGGTTCGTGCT

GGTCCTTCCTGCACCTTAGGCTGGGGGTGGGGGGCCTGCCGGCGCATTCTCCACGATTGA

GCGCACAGGCCTGAAGTCTGGACAACCCGCAGAACCGAAGCTCCGAGCAGCGGGTCGGTG

GCGAGTAGTGGGGGTCGGTGGCGAACAAGTGGTGGTGGGCCGGGGCCGCATAACTCGAGG

ACTTTCCTCCCGGAGCAGTCCCTAAAAACCCGGGGGCGC

CF147366

GACGAGGACAATTGTAGAGGCTGTCTCTTCCTCCCTCCTTGTCACCCCATAGGGTGTACC

ACTGGTCTTGGAAGCACCCATCCTTAATACGATGATTTTTCTGTCGTGTGAAAATGAAGC

CAGCAGGCTGCCCCTAGTCAGTCCTTCCTTCCAGAGAAAAAGAGATTTGAGAAAGTGCCT

GGGTAATTCACCATTAATTTCCTCCCCCAAACTCTCTGAGTCTTCCCTTAATATTTCTGG

TGGTTCTGACCAAAGCAGGTCATGGTTTGTTGAGCATTTGGGATCCCAGTGAAGTAGATG

TTTGTAGCCTTGCATACTTAGCCCTTCCCAGGCACAAACGGAGTGGCAGAGTGGTGCCAA

CCCTGTTTTCCCAGTCCACGTAGACAGATTCACAGTGCGGAATTCTGGAAGCTGGAGACA

GACGGGCTCTTTGCAGAGCCGGGACTCTGAGAGGGACATGAGGGCCTCTGCCTCTGTGTT

CATTCTCTGATGTCCTGTACCTGGGCTCAGTGCCCGGTGGGACTCATCTCCTGGCCGCGC

AGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCTGC

CF147143

CACGAGGCGACTTGCGAGCTGGGAGCGATTTAAAACGCTTTGGATTCCCCCGGCCTGGGT

GGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCCT

CGGCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCTT

GCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAGC

GGCGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTCGGCGGA

GCCGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGGACGTCCCCAGCTCCCGT

GCCTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTGTCCCGGAGCTCGCTGAA

ACCCTGTGCCCAGGCAGCCACCCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGGA

AGAGTACCCAGCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACCAG

CCTATGGCCAGTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAACGC

GACATGACTCCCTGTTGCCTGTGGACAGTTACCAATCTTGGGCTCTCGCTGGTGGCTGGA

ACAGCCAGATGTGTTGCCAGGGAG

BT007410

atggagcccg gcaattatgc caccttggat ggagccaagg atatcgaagg cttgctggga

gcgggagggg ggcggaatct ggtcgcccac tcccctctga ccagccaccc agcggcgcct

acgctgatgc ctgctgtcaa ctatgccccc ttggatctgc ca9gctcggc ggagccgcca

aagcaatgcc acccatgccc tggggtgccc caggggacgt ccccagctcc cgtgccttat

ggttactttg gaggcgggta ctactcctgc cgagtgtccc ggagctcgct gaaaccctgt

gcccaggcag ccaccctggc cgcgtacccc gcggagactc ccacggccgg ggaagagtac

cccagccgcc ccactgagtt tgccttctat ccgggatatc cgggaaccta ccagcctatg

gccagttacc tggacgtgtc tgtggtgcag actctgggtg ctcctggaga accgcgacat

gactccctgt tgcctgtgga cagttaccag tcttgggctc tcgctggtgg ctggaacagc

cagatgtgtt gccagggaga acagaaccca ccaggtccct tttggaaggc agcatttgca

gactccagcg ggcagcaccc tcctgacgcc tgcgcctttc gtcgcggccg caagaaacgc

attccgtaca gcaaggggca gttgcgggag ctggagcggg agtatgcggc taacaagttc

atcaccaagg acaagaggcg caagatctcg gcagccacca gcctctcgga gcgccagatt

accatctggt ttcagaaccg ccgggtcaaa gagaagaagg ttctcgccaa ggtgaagaac

agcgctaccc cttag

BC007092

ggattccccc ggcctgggtg gggagagcga gctgggtgcc ccctagattc cccgcccccg

cacctcatga gccgaccctc ggctccatgg agcccggcaa ttatgccacc ttggatggag

ccaaggatat cgaaggcttg ctgggagcgg gaggggggcg gaatctggtc gcccactccc

ctctgaccag ccacccagcg gcgcctacgc tgatgcctgc tgtcaactat gcccccttgg

atctgccagg ctcggcggag ccgccaaagc aatgccaccc atgccctggg gtgccccagg

ggacgtcccc agctcccgtg ccttatggtt actttggagg cgggtactac tcctgccgag

tgtcccggag ctcgctgaaa ccctgtgccc aggcagccac cctggccgcg taccccgcgg

agactcccac ggccggggaa gagtacccca gccgccccac tgagtttgcc ttctatccgg

gatatccggg aacctaccag cctatggcca gttacctgga cgtgtctgtg gtgcagactc

tgggtgctcc tggagaaccg cgacatgact ccctgttgcc tgtggacagt taccagtctt

gggctctcgc tggtggctgg aacagccaga tgtgttgcca gggagaacag aacccaccag

gtcccttttg gaaggcagca tttgcagact ccagcgggca gcaccctcct gacgcctgcg

cctttcgtcg cggccgcaag aaacgcattc cgtacagcaa ggggcagttg cgggagctgg

agcgggagta tgcggctaac aagttcatca ccaaggacaa gaggcgcaag atctcggcag

ccaccagcct ctcggagcgc cagattacca tctggtttca gaaccgccgg gtcaaagaga

agaaggttct cgccaaggtg aagaacagcg ctacccctta agagatctcc ttgcctgggt

gggaggagcg aaagtggggg tgtcctgggg agaccaggaa cctgccaagc ccaggctggg

gccaaggact ctgctgagag gcccctagag acaacaccct tcccaggcca ctggctgctg

gactgttcct caggagcggc ctgggtaccc agtatgtgca gggagacgga accccatgtg

acagcccact ccaccagggt tcccaaagaa cctggcccag tcataatcat tcatcctgac

agtggcaata atcacgataa ccagtactag ctgccatgat cgttagcctc atattttcta

tctagagctc tgtagagcac tttagaaacc gctttcatga attgagctaa ttatgaataa

atttggaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa

U57052

cgggtgcccc ctagattccc cgcccccgca cctcatgagc cgaccctcgg ctccatggag

cccggcaatt atgccacctt ggatggagcc aaggatatcg aaggcttgct gggagcggga

ggggggcgga atctggtcgc ccactcccct ctgaccagcc acccagcggc gcctacgctg

atgcctgctg tcaactatgc ccccttggat ctgccaggct cggcggagcc gccaaagcaa

tgccacccat gccctggggt gccccagggg acgtccccag ctcccgtgcc ttatggttac

tttggaggcg ggtactactc ctgccgagtg tcccggagct cgctgaaacc ctgtgcccag

gcagccaccc tggccgcgta ccccgcggag actcccacgg ccggggaaga gtaccccagc

cgccccactg agtttgcctt ctatccggga tatccgggaa cctaccacgc tatggccagt

tacctggacg tgtctgtggt gcagactctg ggtgctcctg gagaaccgcg acatgactcc

ctgttgcctg tggacagtta ccagtcttgg gctctcgctg gtggctggaa cagccagatg

tgttgccagg gagaacagaa cccaccaggt cccttttgga aggcagcatt tgcagactcc

agcgggcagc accctcctga cgcctccgcc tttcgtcgcg gccgcaagaa acgcattccg

tacagcaagg ggcagttgcg ggagctggag cgggagtatg cggctaacaa gttcatcacc

aaggacaaga ggcgcaagat ctcggcagcc accagcctct cggagcgcca gattaccatc

tggtttcaga accgccgggt caaagagaag aaggttctcg ccaaggtgaa gaacagcgct

accccttaag agatctcctt gcctgggtgg gaggagcgaa agtgggggtg tcctggggag

accaggaacc tgccaagccc aggctggggc caaggactct gctgagaggc ccctagagac

aacacc

U81599

tcctaatacg actcactata gggctcgagc ggccgcccgg gcaggtcgaa tgcaggcgac

ttgcgagctg ggagcgattt aaaacgcttt ggattccccc ggcctgggtg gggagagcga

gctgggtgcc ccctagattc cccgcccccg cacctcatga gccgaccctc ggctccatgg

agcccggcaa ttatgccacc ttggatggag ccaaggatat cgaaggcttg ctgggagcgg

gaggggggcg gaatctggtc gcccactccc ctctgaccag ccacccagcg gcgcctacgc

tgatgcctgc tgtcaactat gcccccttgg atctgccagg ctcggcggag ccgccaaagc

aatgccaccc atgccctggg gtgccccagg ggacgtcccc agctcccgtg ccttatggtt

actttggagg cgggtactac tcctgccgag tgtcccggag ctcgctgaaa ccctgtgccc

aggcagccac cctggccgcg taccccgcgg agactcccac ggccggggaa gagtacccca

gtcgccccac tgagtttgcc ttctatccgg gatatccggg aacctaccac gctatggcca

gttacctgga cgtgtctgtg gtgcagactc tgggtgctcc tggagaaccg cgacatgact

ccctgttgcc tgtggacagt taccagtctt gggctctcgc tggtggctgg aacagccaga

tgtgttgcca gggagaacag aacccaccag gtcccttttg gaaggcagca tttgcagact

ccagcgggca gcaccctcct gacgcctgcg cctttcgtcg cggccgcaag aaacgcattc

cgtacagcaa ggggcagttg cgggagctgg agcgggagta tgcggctaac aagttcatca

ccaaggacaa gaggcgcaag atctcggcag ccaccagcct ctcggagcgc cagattacca

tctggtttca gaaccgccgg gtcaaagaga agaaggttct cgccaaggtg aagaacagcg

ctacccctta agagatctcc ttgcctgggt gggaggagcg aaagtggggg tgtcctgggg

agaccagaaa cctgccaagc ccaggctggg gccaaggact ctgctgagag gcccctagag

acaacaccct tcccaggcca ctggctgctg gactgttcct caggagcggc ctgggtaccc

agtatgtgca gggagacgga accccatgtg acaggcccac tccaccaggg ttcccaaaga

acctggccca gtcataatca ttcatcctca cagtggcaat aatcacgata accagt

CB120119

ATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTAGTCAGTCCTTCCTTCCAG

AGAAAAAGAGATTTGAGAAAGTGCCTGGGTAATTCACCATTAATTTCCTCCCCCAAACTC

TCTGAGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGCAGGTCATGGTTTGTTGAG

CATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCCCTTCCCAGGCA

CAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCACA

GTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAGG

GACATGAGGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGCC

CGGTGGGACTCATCTCCTGGCTGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCTG

CACCTTAGGCTGGGGGTGGGGGGCCT

CB125764

ATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTAGTCAGTCCTTCCTTCCAG

AGAAAAAGAGATTTGAGAAAGTGCCTGGGTAATTCACCATTAATTTCCTCCCCCAAACTC

TCTGAGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGCAGGTCATGGTTTGTTGAG

CATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCCCTTCCCAGGCA

CAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCACA

GTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAGG

GACATGAGGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGCC

CGGTGGGACTCATCTCCTGGCTGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCTG

CACCTTAGGCTGGGGGTGGGGGGGGCCTGCCGGCGCATTCTCCACGATTGAGCGCACAGG

CCTGAAGTCTGGACAACCCGCAGAACCGAAGCTCCGAGCAGCGGGTCGGTGGCGAGT

AU098628

ATTTAAAACGCTTTGGATTCTTTCGTCCTGCGTGGGGAGAGCGAGCTGGGTGCCCCCTAG

ATTCCCCGCCCCCGCACCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGCACTTATGC

CACCTTGGATGGAGCCAAGGATATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAATCT

GGTCGCCCACTCCCCTCTGACCAGCCACCCAGCGGCGCCTACGCTGATGCCTGCTGTCAA

TTATGCCCCCTTGCATCTGCCAGGCTCGGCGGAGCCGCCAAAGCAATGCCACCCATGCCC

CB126130

ATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTAGTCAGTCCTTCCTTCCAG

AGAAAAAGAGATTTGAGAAAGTGCCTGGGTAATTCACCATTAATTTCCTCCCCCAAACTC

TCTGAGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGCAGGTCATGGTTTGTTGAG

CATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCCCTTCCCAGGCA

CAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCACA

GTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAGG

GACATGAGGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGCC

CGGTGGGACTCATCTCCTGGCTGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCTG

CACCTTAGGCTGGGGGTGGGGGGCCTGC

BI023924

AGGCCGCACCCAGTCTTAAGGTGCAGTGAAGGACAGCACGAACCCGCTGTGCTTTGCTGC

GCGGCAGGAGATGAGTCCCACCGGGCACTGAGCCCAGGTACAGGACATCAGAGAATGAAC

ACAGAGGCAGAGGCCCTCATGTCCCTCTCAGAGTCCCGGCTCTGCAAAGAGCCCGTCTGT

CTCCAGCTTCCAGAATTCCGCACTGTGAATCTGTCTACGTGGACTGNGAAAACAGGGTTG

GCACCACTCTGCCACTCCGTTTGTGCCTNGGGGCGGGCAGAGGG

BM767063.1

AAAAACGCTTTGGATTCCCCCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATT

CCCCGCCCCCGCACCTCATGAGCCGACCCTCGGCTCCATGGAGCCCGGCAATTATGCCAC

CTTGGATGGAGCCAAGGATATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAATCTGGT

CGCCCACTCCCCTCTGACCAGCCACCCAGCGGCGCCTACGCTGATGCCTGCTGTCAACTA

TGCCCCCTTGGATCTGCCAGGCTCGGCGGAGCCGCCAAAGCAATGCCACCCATGCCCTGG

GGTGCCCCAGGGGACGTCCCCAGCTCCCGTGCCTTATGGTTACTTTGGAGGCGGGTACTA

CTCCTGCCGAGTGTCCCGGAGCTCGCTGAAACCCTGTGCCCAGGCAGCCACCCTGGCCGC

GTACCCCGCGGAGACTCCCACGGCCGGGGAAGAGTACCCCAGCCGCCCCACTGAGTTTGC

CTTCTATCCGGGATATCCGGGAACCTACCAGCCTATGGCCAGTTACCTGGACGTGTCTGT

GGTGCAGACTCTGGGTGCTCCTGGAGAACCGCGACATGACTCCCTGTTGCCTGTGGACAG

TTACCAGTCTTGGGCTCTCGCTGGTGGCTGGAACAGCCAGATGTGTTGCCA

BM794275

GCAGACTCTGGGTGCTCCTGGAGAACCGCGACGTGACTCCCTGTTGCCTGTGGACAGTTA

CCACTCTTGGGCTCTCGCTGGTGGCTGGAACAGCCAGATGTGTTGCCAGGGAGAACAGAA

CCCACCAGGTCCCTTTTGGAAGGCAGCATTTGCAGACTCCAGCGGGCAGCACCCTCCTGA

CGCCTGCGCCTTTCGTCGCGGCCGCAAGAAACGCATTCCGTACAGCAAGGGGCAGTTGCG

GGAGCTGGAGCGGGAGTATGCGGCTAACAAGTTCATCACCAAGGACAAGAGGCGCAAGAT

CTCGGCAGCCACCAGCCTCTCGGAGCGCCAGATTACCATCTGGTTTCAGAACCGCCGGGT

CAAAGAGAAGAAGGTTCTCGCCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTT

GCCTGGGTGGGAGGATCTAAAGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAAGCCC

AGGCTGGGGCCAAGGACT

BQ363211

ACGCTGCACTGCGTTTCAAAGAGAAGAAGGTTCTCGCCAAGGTGAAGAACAGCGCTACCC

CTTAAGAGATCTCCTTGCTTGGGTGGGAGGAGCGAAAGTGGGGGTGTCCTGGGGAGACCA

GGAACCTGCCATCACCAGGCTGGGCCCAAGGACTCTGCTGAGAGGCCCCTAGAGACAACA

CCCTTCCCAGGCCATTGCTTGCTGGACTGTGCCTCAGGAGCGGCCTGGGTACC

BM932052

GAGTTTTCCAATTTCCAAAGAAAAATTTAGGTTTCCTGCAGCCGTGACATATGTGTGTGC

ACTGGGATGGGTTAATGTGTGTGTGTGTGTGTGTATGCGCATGTATTGGGAGTGGGGGCA

GAAACGTGTTTCCAGAATTTGCCTGTAGAATCTAAAAGAGTGGCCAAGAGTCTGGAAATG

CATGAAGACTGGACGTATGTGATGGTGGGCAAAGGCCTGACTGTGTGTGGTGTGTGGGTA

TGTTTGCAGATTCGCGGGTGTGAGAGCAGTGATGGGTGAGGGTGGCCTTCAGGAGCCAAG

GCTGATCGGTGGTGAGAGAACAAGCCGGAAGCCAGGGTGCTGTCCTGGTATGCTTTGGAG

GAACAGGATTGCACGTGCGCCTGTAGGGTGACCTGTGTGCACCTGTGAGATGACTTAGCT

TGGGGCTTGCAAGGCCTGGGTCTGCATGGGTGGGTATCTGACCATGCCTTTTCCTCCCTC

CCTTTCACGCCGCGCAGACTCCAGCGGGCAGCACCCTCCTGACGCCTGCGCCTTTCGTC

AA357646.1

CCGGCCTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCAT

GAGCCGACCCTCGGCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGAT

ATCGAAGGCTTGCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACC

AGCCACCCAGCGGCGCCTACGCTTGATGCCTGCTTGTCAACTATGCCCCCTTGGATCTGC

AW609525

ACCGCGGGTCAAATTTATTCATAATTAGCTCAATCATGAAAGCGGTTCTAAAGTGCTCTA

CAGAGCTCTAGATAGAAAATATGAGGCTAACGATCATGGCAGCTAGTACTGGTTATCGTG

ATTATGGCCACTGTCAGGATGAATGATAATGACTGGGCCAGGTCCTTTGGAAACCCTGGT

GGAGTGGGCTGTCACATGGGGTCCCGTCTCCCTGCACATACTGGGTACCCAGGCCGCTCC

TGAGGAACAGTCCAGCAGCCAGTGGCCTGGGAAGGGTGTGGTCTCTAGGGGCCTCTCAGC

AGAGTCCTTGGCCCCAGCCTGGGCTTGGCAGGTCCCTGGTCTCCCCAGGACACCCCCACT

TTCGCTCCTCCCACCCAGGCAAGGAGATCTCTTAAGGGGTAGCGCTGTTCTTCACCTTGG

CGAGAACCTTCTTCTCTTTGAACCGGCGGTGCGGCGTGGGGTACCGAGC

CB126919

ATTTTTCTGTCGTGTGAAAATGAAGCCAGCAGGCTGCCCCTAGTCAGTCCTTCCTTCCAG

AGAAAAAGAGATTTGAGAAAGTGCCTGGGTAATTCACCATTAATTTCCTCCCCCAAACTC

TCTGAGTCTTCCCTTAATATTTCTGGTGGTTCTGACCAAAGCAAGTCATGGTTTGTTGAG

CATTTGGGATCCCAGTGAAGTAGATGTTTGTAGCCTTGCATACTTAGCCCTTCCCAGGCA

CAAACGGAGTGGCAGAGTGGTGCCAACCCTGTTTTCCCAGTCCACGTAGACAGATTCACA

GTGCGGAATTCTGGAAGCTGGAGACAGACGGGCTCTTTGCAGAGCCGGGACTCTGAGAGG

GACATGAAGGCCTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGGGCTCAGTGCC

CGGTGGGACTCATCTCCTGGCTGCGCAGCAAAGCCAGCGGGTTCGTGCTGGT

AW609336

CCAACGAGAAGAAGGTTCTCGCAAGGTGAAGAACAGCGCTACCCCTTAAGAGATCTCCTT

GCGTGGGTGGGAGGAGCGAAAGTGGGGGTGTCCTGGGGAGACCAGGAACCTGCCAGCCCA

GGCTGAGGCCAAGGACTCTGCTGAGAGGCCCCTAGAGACAACACCCTTCCCAGGCCACTG

GATGCTGAACTGTCCCTCAGGAGCGGCCTGGGTACCCAGTATGTGCAGGGAGACGGAACC

CCATGTGACAGCCCACTCCACCAGGGTTCCCAAAGAACCTGGCCCCAGTCATAATCATTC

ATCCTGACAGTGGCAATAATCACGATAACCAGTACTAGCTGCCATGATCGTAAGCCTCAT

ATTTGCTATCTAGAGCTCTGTAGAGCACTTTAGAAACCGCTTTCATGAATTGAGCTAATT

ATGACTCAATTTGAACCGGCGTCCGGCGTG

AW609244

ACGCGCACCGCGGTCAAGAGAAGAAGGTTCTCGCAAGGTGAAGAACAGCGCTACCCCTTA

AGAGATCTCCTTGCGTGGGTGGGAGGAGCGAAAGTGGGGGTGTCCTGGGGAGACCAGGAA

CCTGCCAAGCCCAGGCTGTGGCCAAGGACTCTGCTGAGAGGCCCCTATGAGACAACACCC

TTCCCAGGCCACTGGCTGCTGGGACTGTTCCTCAGGAGCGGCCTGGGTACCCGAGTAATG

TGCAGGGGAGACGGAACCCCATGTGACAGCCCACTCCACCAGGGTTCCCAAAAGAACCCT

GGCCCAGTCATAATCATTCATCCTGACAGTGGCAATAATCACGATAACCAGTACTAGCTG

CCATGATCGTAAGCCTCATATTTGCTATCTAGAGCTCTGTAGAGCCCTTTAGAAACCGCT

TTCATGAATGGAGCTAAATTATGAATACATTTGAACCGGCGATCCGACGTGA

BF855145

CTAGAGGATCCCGGAAGCAACTGCAACAGGTTCCCAAAGAACCGGGCCAGTCATAATCAT

TCATCCTGACAGGGCAATAATCACGATAACCAGTACTAGCTGCCATGATCGTTAGCCTCA

TATTTTCTATCTAGAGCTCTGTAGAGCACTTTAGAAACCGCTTTCATGAATGGAGCTAAT

TATGAATAAATTTGGAAGGCGATCCCTTGGCAGGGAAGCTTTCTCTCAGACCCCCTTCCA

TTACACCTCTCACCCTGGTAACAGCAGGAAGACTGAGGAGAGGGGAACGGGCAGATTCGT

GGTGTTGCAGTGTGCTTCCG

AU126914

GAGCGAATGCAGGCGACTTGCGAGCTGGGAGCGATTTAAAACGCTTTGGATTCCCCCGGC

CTGGGTGGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCC

GACCCTCGGCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGA

AGACTTGCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCA

CCCAGCGGCGCCTACGCTGATGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTC

GGCGGAGCCGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGGACGTCCCCAGC

TCCCGTGCCTTATGGTTACTTTGGAGGCGGGTNCTACTCCTGCCGAGTGTCCCGGAGCTC

GCTGAAACCCTGTGCCCANNCANCCACCCTGGCCGCGTN

CB126449

CTCTGCCTCTGTGTTCATTCTCTGATGTCCTGTACCTGTGCTCAGTGCCCGGTGGGACTC

ATCTCCTGGCTGCGCAGCAAAGCCAGCGGGTTCGTGCTGGTCCTTCCTGCACCTTCGGCT

GGGGGTGGGGGGCCTGCCGGCGCATTCTCCACGATT

AW582404

ACGCTGCACCGCCGGTCCAAGAGAAGAAGGTTCTCGCCAAGGTGAAGAACAGCGCTACCC

CTTTAAGAGATCTCCTTGCTGGGGTGGGAGGAGCGAAAGTGGGGGTGTCTGGGGAGACCA

GGAACCTGCCAGCCCCAGGCTGGGCCCAAGGACTCTGCTGAGAGGCCCCTAGAGACAACA

CCCTTCCCAGGCCACTGTCTGCTGGACTGTTCCTCAGGAGCGGCCTGGGTACNCAGTATG

TGCAGGGAGACGGAACCCCATGTGACAGCCCACTCCACCAGGGTTCCCAAAGAACCTGGC

CCAGTCATAATCATTCATCCTGACAGTGGCAATAATCACGATAACCAGTACTAGCTGCCA

TGATCGTTAGCCTCATATTTTCTATCTAGAGCTCTGTAGAGCACTTTAGAAACCGCTTTC

ATGAATTGAGCTACTTATGAATCACTTTGAACCGGCGGTGCGGCGTG

BX641644

GGGGGAGAGCGAGCTGGGTGCCCCCTAGATTCCCCGCCCCCGCACCTCATGAGCCGACCC

TCGGCTCCATGGAGCCCGGCAATTATGCCACCTTGGATGGAGCCAAGGATATCGAAGGCT

TGCTGGGAGCGGGAGGGGGGCGGAATCTGGTCGCCCACTCCCCTCTGACCAGCCACCCAG

CGGCGCCTACGCTGACGCCTGCTGTCAACTATGCCCCCTTGGATCTGCCAGGCTCGGCGG

AGCCGCCAAAGCAATGCCACCCATGCCCTGGGGTGCCCCAGGGGACGTCCCCAGCTCCCG

TGCCTTATGGTTACTTTGGAGGCGGGTACTACTCCTGCCGAGTGTCCCGGAGCTCGCTGA

AACCCTGTGCCCAGGCAGCCACCCTGGCCGCGTACCCCGCGGAGACTCCCACGGCCGGGG

AAGAGTACCCCAGCCGCCCCACTGAGTTTGCCTTCTATCCGGGATATCCGGGAACCTACC

AGCCTATGGCCAGTTACCTGGACGTGTCTGTGGTGCAGACTCTGGGTGCTCCTGGAGAAC

CGCGACATGACTCCCTGTTGCCTGTGGACAGTTACCAGTCTTGGGCTCTCGCTNGTGGCT

GGAACAGCCAGATGTGTTGCCAGGGAGAACAGAACCCACCAGGTCCCTTTTGGAAGGCAG

CATTTG

Sequences from Table 4 not disclosed above

AW006861 (IMAGE Clone ID:: 2497262)

GCTGAGTTCTGAAGCTTCTGAGTTCTGCAGCCTCACCTCTGAGAAAACCTCTTTTCCACC

AATACCATGAAGCTCTGCGTGACTGTCCTGTCTCTCCTCATGCTAGTAGCTGCCTTCTGC

TCTCTAGCGCTCTCAGCACCAATGGGCTCAGACCCTCCCACCGCCTGCTGCTTTTCTTAC

ACCGCGAGGAAGCTTCCTCGCAACTTTGTGGTAGATTACTATGAGACCAGCAGCCTCTGC

TCCCAGCCAGCTGTGGTATTCCAAACCAAAAGAAGCAAGCAAGTCTGTGCTGATCCCAGT

GAATCCTGGGTCCAGGAGTACGTGTATGACCTGGAACTGAACTGAGCTGCTCAGAGACAG

GAAGTCTTCAGGGAAGGTCACCTGAGCCCGGATGCTTCTCCATGAGACACATCTCCTCCA

TACTCAGGACTCCTCTCCGCAGTTCCTGTCCCTTCTCTTAATTTAATCTTTTTTATGTGC

CGTGTTATTGTATTAGGTGTCATTTCCATTATTTATATTAGTTTAGCCAAAGGATAAGTG

TCCCCTATGGGGATGGTCCACTGTCACTGTTTCTCTGCTGTTGCAAATACATGGATAACA

CATTTGATTCTGTGTGTTTTCATAATAAAACTTTAAAATAAAATGCAAAAAAAAAAAAAA

AAAA

X59770

GCCACGTGCTGCTGGGTCTCAGTCCTCCACTTCCCGTGTCCTCTGGAAGTTGTCAGGAGC

AATGTTGCGCTTGTACGTGTTGGTAATGGGAGTTTCTGCCTTCACCCTTCAGCCTGCGGC

ACACACAGGGGCTGCCAGAAGCTGCCGGTTTCGTGGGAGGCATTACAAGCGGGAGTTCAG

GCTGGAAGGGGAGCCTGTAGCCCTGAGGTGCCCCCAGGTGCCCTACTGGTTGTGGGCCTC

TGTCAGCCCCCGCATCAACCTGACATGGCATAAAAATGACTCTGCTAGGACGGTCCCAGG

AGAAGAAGAGACACGGATGTGGGCCCAGGACGGTGCTCTGTGGCTTCTGCCAGCCTTGCA

GGAGGACTCTGGCACCTACGTCTGCACTACTAGAAATGCTTCTTACTGTGACAAAATGTC

CATTGAGCTCAGAGTTTTTGAGAATACAGATGCTTTCCTGCCGTTCATCTCATACCCGCA

AATTTTAACCTTGTCAACCTCTGGGGTATTAGTATGCCCTGACCTGAGTGAATTCACCCG

TGACAAAACTGACGTGAAGATTCAATGGTACAAGGATTCTCTTCTTTTGGATAAAGACAA

TGAGAAATTTCTAAGTGTGAGGGGGACCACTCACTTACTCGTACACGATGTGGCCCTGGA

AGATGCTGGCTATTACCGCTGTGTCCTGACATTTGCCCATGAAGGCCAGCAATACAACAT

CACTAGGAGTATTGAGCTACGCATCAAGAAAAAAAAAGAAGAGACCATTCCTGTGATCAT

TTCCCCCCTCAAGACCATATCAGCTTCTCTGGGGTCAAGACTGACAATCCCGTGTAAGGT

GTTTCTGGGAACCGGCACACCCTTAACCACCATGCTGTGGTGGACGGCCAATGACACCCA

CATAGAGAGCGCCTACCCGGGAGGCCGCGTGACCGAGGGGCCACGCCAGGAATATTCAGA

AAATAATGAGAACTACATTGAAGTGCCATTGATTTTTGATCCTGTCACAAGAGAGGATTT

GCACATGGATTTTAAATGTGTTGTCCATAATACCCTGAGTTTTCAGACACTACGCACCAC

AGTCAAGGAAGCCTCCTCCACGTTCTCCTGGGGCATTGTGCTGGCCCCACTTTCACTGGC

CTTCTTGGTTTTGGGGGGAATATGGATGCACAGACGGTGCAAACACAGAACTGGAAAAGC

AGATGGTCTGACTGTGCTATGGCCTCATCATCAAGACTTTCAATCCTATCCCAAGTGAAA

TAAATGGAATGAAATAATTCAAACACAAAAAAAAAAAAAAAAAAAAAA

AB000520

GGATCCAAGCTATTGTCCTGCCCATGGCTTCCCATCTCAGGACGCTCTCTGGCCGCTATC

ATCCCAGCAGTGGAGTTCAGCCCACTACTCTGAACCAGCCGCAGGTGGCTGCTATGGGAC

TGAAGCCATGAATGGTGCCGGCCCTGGCCCCGCCGCAGCCGCCCCGGTCCCAGTCCCGGT

CCCGGTCCCGGACTGGCGGCAGTTCTGCGAGCTGCATGCGCAGGCGGCCGCCGTGGACTT

TGCGCACAAGTTCTGCCGTTTCCTGCGGGACAACCCAGCTTACGACACGCCCGACGCCGG

CGCCTCCTTCTCCCGCCACTTCGCCGCCAACTTCCTGGACGTCTTCGGCGAGGAGGTGCG

CCGCGTGCTGGTGGCTGGGCCGACGACTCGGGGCGCGGCCGTGAGCGCAGAGGCCATGGA

GCCGGAGCTCGCGGACACCTCTGCACTCAAGGCGGCGTCCTACGGCCACTCGCGGAGCTC

GGAGGACGTGTCCACGCACGCGGCCACCAAGGCCCGCGTTCGCAAGGGCTTCTCGCTGCG

CAACATGAGCCTGTGCGTGGTGGACGGCGTGCGCGACATGTGGCACCGGCGCGCCTCGCC

CGAGCCCGACGCGGCAGCTGCCCCGCGCACCGCCGAGCCCCGCGACAAGTGGACGCGGCG

CCTGAGGCTGTCGCGGACGCTGGCTGCCAAGGTGGAGCTGGTGGACATTCAACGCGAGGG

GGCGCTGCGCTTCATGGTGGCCGACGACGCGGCCGCGGGCTCCGGGGGCTCGGCTCAGTG

GCAGAAGTGCCGCCTGCTCCTGCGCAGGGCTGTGGCCGAGGAACGCTTCCGCCTGGAGTT

CTTCGTGCCGCCCAAAGCCTCCAGGCCCAAGGTCAGCATCCCACTGTCAGCCATCATTGA

GGTCCGCACCACCATGCCCCTGGAAATGCCAGAGAAGGATAACACATTCGTCCTCAAGGT

AGAGAATGGAGCCGAATACATCTTGGAGACCATCGACTCTCTGCAGAAGCACTCGTGGGT

AGCTGACATCCAGGGCTGCGTGGACCCCGGTGACAGTGAGGAAGACACCGAGCTCTCCTG

TACCCGAGGAGGCTGTCTGGCCAGCCGCGTGGCCTCCTGCAGCTGTGAGCTCCTGACTGA

TGCAGTCGACCTGCCCCGCCCCCCAGAGACGACAGCCGTGGGTGCAGTGGTGACAGCCCC

CCACAGCCGAGGTCGAGATGCCGTCAGAGAATCCCTGATCCACGTCCCGCTAGAGACCTT

TCTGCAGACCCTGGAATCCCCGGGCGGCAGCGGCAGTGACAGCAATAACACAGGGGAACA

GGGTGCAGAGACGGATCCCGAGGCTGAACCCGAGCTGGAGCTATCCGACTACCCATGGTT

CCACGGGACACTGTCCCGGGTCAAGGCTGCTCAACTGGTTCTGGCAGGGGGGCCCCGGAA

CCACGGCCTCTTCGTGATCCGCCAAAGTGAGACTCGGCCTGGGGAGTACGTGCTGACCTT

CAACTTCCAGGGCAAGGCCAAGCACCTGCGCCTGTCCCTGAACGGCCACGGCCAGTGTCA

CGTACAGCATCTGTGGTTCCAGTCTGTGCTTGACATGCTCCGCCACTTCCACACACACCC

CATCCCACTGGAGTCAGGGGGCTCGGCCGACATCACCCTTCGCAGCTATGTGCGGGCCCA

GGACCCCCCACCAGAGCCGGGCCCCACGCCCCCTGCCGCGCCCGCGTCCCCGGCCTGCTG

GAGCGACTCGCCCGGCCAGCACTACTTCTCCAGCCTCGCCGCGGCCGCCTGCCCGCCTGC

CTCGCCCTCCGACGCCGCCGGCGCCTCCTCGTCTTCCGCCTCGTCGTCCTCTGCCGCGTC

GGGGCCCGCCCCCCCGCGCCCCGTCGAGGGCCAGCTCAGCGCGCGGAGCCGCAGCAACAG

CGCCGAGCGCCTGCTGGAGGCCGTGGCCGCCACCGCCGCCGAGGAGCCCCCGGAGGCCGC

GCCCGGCCGCGCGCGCGCCGTGGAGAACCAGTACTCCTTCTACTAGCCCGCGGCGCCGCC

CGGGTGGGACACGCCAAGCTCTTCAGTGAAGACACGATGTTATTAAAAGCCTGTTTTAGG

GACTGCAAAA

AI820604 (IMAGE Clone Id: 1605108

GATTCCAGCACGGGCTTCGCAGACTGCAGGACACAGAGGCACGCGTGCACATCATGTCTT

CTAAGGAATTTGAACACTGTTGAGAAGACTGTGTACAAGAGAGATGTGCCATGTCAGCCT

TGCAAGGGACAGCGTGAAAACTACCCATCTCCGGTCACCAAGTTGCAGGAGGCCAGGAGC

CAGGAGGGGAAACCGCTCAGTTTGCAAAACGTCGCTTCCACAAGCCTGATGGCTGAAACT

GCTCACTGTACCCTGAAACCAGCTTTACCTACAGCTTCTGAGATAAACTGCTGCAACTCT

GGGACCCACGATGCCTATCACAGTGGCTCATCAATGGAACCTGCCGGCTCCCAACCCTTC

CTAGGGCCCATGAACTCTCTGAAAAGAGGAACAGAAATATTTCTCCTTTTTGTAAAATCT

TTAACCTTCCCTTTGTTCTTCATGTACACGCTGAACTGCAATTCTTCTTCCCAAATAAAA

CATTAAATTTAAAAAA

AI087057 (IMAGE Clone ID: 1671188)

GGCCCCGGAGGGAGAGTAACCCGGCCCATCCATCCGTCGCCCGGTTCTTGGGGAACTACT

TTCAGGGGCTTCTTGCCGTCCCCTCATCAGCTCTGTGCGAACCCTCTGTCGGCAGCCATT

GAGGAGACCCTGCCCCCTGGACCCTGACCACATATAGATTGAGGCCGAGGAGTGGCTGCC

CTGTCCCTTTTATGACAGCCCGCAGAAGCCCCGGGGTGAGGCATGGAGGAGGCAGGCGAC

AGCTGACAGGGACCCTGTTGGCCTCCAGCATGTCCAGCCAGCCGGGCAGGATTTCTCTGC

TTCTGGCTGGCAGCCAGGAACTGAGTATGACAATGTTGTACTAAAGAAAGGCCCAAAGTG

ACAGAGGCAGCAGAGGGATGGTCCACCGCCCCTTGGCTTCTGCTGGTGACTCCTCCTGGC

CACTGCATCAGAAGAACCTCCTCTGCCCCTTCTGGAGCCCGAGGCCTGGCCTGTCTTCGT

TGGGGCTGATAAATTGCCTCTCCCAGGGCCTGCTGGGTGAGTCACCATCCCAAAGCAGGA

AGGGTGCCCTGGAGAGAACCACCCTCCTCCTACTCTTTTTCCACTTCCTCCTCTTTCTTT

CCCCAGCTGAGGAGGAACCTGGGGCATTTAGGGCAGAGGACAAAAGGATGTCAGCAATTG

CTTGGGCTGCTTGGCTATGCAAGCCTCCTGCCTGCTGATGGCCACTTCAGGGACAGCCTG

GGCCCAGGCACCCAGGGGGATGGCGGCAGCTTCCTGCACCTTTCAGATTTCTTGGTGGCA

TTAAAGCATTTTCAGAAC

AJ272267

GGCGGGCCTGGACGGCCGCGTGCTGTACTGGCCACGCGGCCGCGTCTGGGGTGGCTCCTC

ATCCCTCAATGCCATGGTCTACGTCCGTGGGCACGCCGAGGACTACGAGCGCTGGCAGCG

CCAGGGCGCCCGCGGCTGGGACTACGCGCACTGCCTGCCCTACTTCCGCAAGGCGCAGGG

CCACGAGCTGGGCGCCAGCCGGTACCGGGGCGCCGATGGCCCGCTGCGGGTGTCCCGGGG

CAAGACCAACCACCCGCTGCACTGCGCATTCCTGGAGGCCACGCAGCAGGCCGGCTACCC

GCTCACCGAGGACATGAATGGCTTCCAGCAGGAGGGCTTCGGCTGGATGGACATGACCAT

CCATGAAGGCAAACGGTGGAGCGCGGCCTGTGCCTACCTGCACCCAGCACTGAGCCGCAC

CAACCTCAAGGCCGAGGCCGAGACGCTTGTGAGCAGGGTGCTATTTGAGGGCACCCGTGC

AGTGGGCGTGGAGTATGTTAAGAATGGCCAGAGCCACAGGGCTTATGCCAGCAAGGAGGT

GATTCTGAGTGGAGGTGCCATCAACTCTCCACAGCTGCTCATGCTCTCTGGCATCGGGAA

TGCTGATGACCTCAAGAAACTGGGCATCCCTGTGGTGTGCCACCTACCTGGGGTTGGCCA

GAACCTGCAAGACCACCTGGAGATCTACATTCAGCAGGCATGCACCCGCCCTATCACCCT

CCATTCAGCACAGAAGCCCCTGCGGAAGGTCTGCATTGGTCTGGAGTGGCTCTGGAAATT

CACAGGGGAGGGAGCCACTGCCCATCTGGAAACAGGTGGGTTCATCCGCAGCCAGCCTGG

GGTCCCCCACCCGGACATCCAGTTCCATTTCCTGCCATCCCAAGTGATTGACCACGGGCG

GGTCCCCACCCAGCAGGAGGCTTACCAGGTACATGTGGGGCCCATGCGGGGCACGAGTGT

GGGCTGGCTCAAACTGAGAAGTGCCAATCCCCAAGACCACCCTGTGATCCAGCCCAACTA

CTTGTCAACAGAAACTGATATTGAGGATTTCCGTCTGTGTGTGAAGCTCACCAGAGAAAT

TTTTGCACAGGAAGCCCTGGCTCCGTTCCGAGGGAAAGAGCTCCAGCCAGGAAGCCACAT

TCAGTCAGATAAAGAGATAGATGCCTTTGTGCGGGCAAAAGCCGACAGCGCCTACCACCC

CTCGTGCACCTGTAAGATGGGCCAGCCCTCCGATCCCACTGCCGTGGTGGATCCGCAGAC

AAGGGTCCTCGGGGTGGAAAACCTCAGGGTCGTCGATGCCTCCATCATGCCTAGCATGGT

CAGCGGCAACCTGAACGCCCCCACAATCATGATCGCAGAGAAGGCAGCTGACATTATCAA

GGGGCAGCCTGCACTCTGGGACAAAGATGTCCCTGTCTACAAGCCCAGGACGCTGGCCAC

CCAGCGCTAAGACAGTTGCTGCTGGAGGATGACCAGGGAAGCCCCCTGATAAGCCAAGAG

GGCCAGCACAGCCCTTGCTCCCAGGCTCCTGCCTGAAACTATCTAGCACACTAGGACCCA

GGTGGTACCCTACTCAGTGGCTGAGAATTGGATAAAGTCTTKGGGAAATGAGACAAGTAC

TGGGCAGTGAATCCAGCTCCTTTTCCCCAGCCTTTCCCTGTGGGCCATTTGGGGAAGGCC

AGCATTYCAGCCTGAGATGTTCCTCCCTGCCTCCTGGGGGGGCARAAGGGVTAGGWTGGT

TAACTCCTGCCGCATCCTTCCCTGCCTCCTGGAGGGACAGAAGGGGAGGATGGTTAACTC

CTGCCGCATCCTTTTTCTTGTGTTCACGTGGCATTCTCTAACCCAGGGCAGTGGTTCCTT

CCCAGGCCATGCACAGAGGCTGGGTGCCTGCCAGACCCACGGAGGGTTCGCGAAGGAAGG

GGCATCCTCCTTCTTGAGCTGCAAGCTTTAGCTGAGGCAGTAAGTCACACAGTAGTTAGT

TCAGCCTGGGCTGGCACATAAGTCCCCAGTGTCCCTGTTGAGAGGGGAAAGTTGCCTGCT

GGTTGAAAAACTGGCTTTTCCTTTCTCGCTGCCTAATTTCACTCTCAGAGTGAGGCAGGT

AACTGGGGCTCCACTGGGTCACTCTGAGAGGGTTGTGGCTCTGGTTCTTATTAAACCAGG

GCCAGGTGCAGGGCTCACACCTGTAATCCCAGCACTTTGGGAAGGTCACTTGAGCTCAGG

AGTTCAAGACCAGCCTGGGCAACATAGTGAGACCTTGTCTCTGGAAAACAATTAGCTGGG

CATGGTGGTACACACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCGGGAGGATGGCTTT

AGCCCAGGAGGTTGAGGCTCCTGTGAACCCTGATGGCACCACTGCACTCCAGCCTGGGTG

ACAGGGTGAGACCCTGTCTCAAAAAAAAA

N30081 (IMAGE Clone ID: 258695)

CCGCCGTTGNCAAAGGGCCCAGAATATGGGCCATGGACNATCTCCATGCCTGGGGAAATT

CCCTCGGGTCTTTTGGNTAACCNCCTTATAGAAAGGTAATGNCATGGAGTCTCTACAGGG

NGCACAAGGTGGACTAATTGATACGAAGAGCCCTGTAAATATGTGGGCAGCGGCAGATTT

TGACCATTTGGACCGAACTGTATTTGACACAGCGCAATATCTGGAACTGGTTGGTCAAAA

ACCTGCTTGTCTTGTTAAATTTCCTCTGTCCAAGGACATGGAATCTCTCTCTAATTTTAC

TTCAAATTTCCCTTTCCTTCATTTCTCTAAAAACGTTAAATAAGAAAGAAGATTGTAAAG

CCAGCATTTGAAGCCTAAGTATTGAAAGTCTTTGACAATTTCTGAAATCAGACTTGACAT

CTTTCCCCCGCCTTGCAAATTTCTTGAAGAAATAAGAAGCTACATGTAAGCATCATCATG

TTTATTAAATTACAATGAGAACTCTCACTCAATCTTGACCAGAGCAGACTCTTAACTTGG

AAGCAGAGTCCCTCTAAAGGTAACTCTTGTGGTCACTCAATATTGTATTGGCATTTGCAT

ATTAAATAGACATTTCAGTAGCATTT

AI700363 (IMAGE Clone ID: 2327403)

TGGCCCGCGGTCGCGGTGGGATCCTAGCCCTGTCTCCTCTCCTGGGAAGGAGTGAGGGTG

GGACGTGACTTAGACACCTACAAATCTATTTACCAAAGAGGAGCCCGGGACTGAGGGAAA

AGGCCAAAGAGTGTGAGTGCATGCGGACTGGGGGTTCAGGGGAAGAGGACGAGGAGGAGG

AAGATGAGGTCGATTTCCTGATTTAAAAAATCGTCCAAGCCCCGTGGTCCAGCTTAAGGT

CCTCGGTTACATGCGCCGCTCAGAGCAGGTCACTTTCTGCCTTCCACGTCCTCCTTCAAG

GAAGCCCCATGTGGGTAGCTTTCAATATCGCAGGTTCTTACTCCTCTGCCTCTATAAGCT

CAAACCCACCAACGATCGGGCAAGTAAACCCCCTCCCTCGCCGACTTCGGAACTGGCGAG

AGTTCAGCGCAGATGGGCCTGTGGGGAGGGGGCAAGATAGATGAGGGGGAGCGGCATGGT

GCGGGGTGACCCCTTGGAGAGAGGAAAAAGGCCACAAGAGGGGCTGCCACCGCCACTAAC

GGAGATGGCCCTGGTAGAGACCTTTGGGGGTCTGGAACCTCTGGACTCCCCATGCTCTAA

CTCCCACACTCTGCTATCAGAAACTTAAACTTGAGGATTTTCTCTGTTTTTCACTCGCAA

TAAATTCAGAGCAAACAAAAAAAAAAAAAAA

AL117406

CAATAGGCCGGCTTTTGAACTGCTTCGCAGGGGACTTGGAACAGCTGGACCAGCTCTTGC

CCATCTTTTCAGAGCAGTTCCTGGTCCTGTCCTTAATGGTGATCGCCGTCCTGTTGATTG

TCAGTGTGCTGTCTCCATATATCCTGTTAATGtGAGCCATAATCATGGTTATTTGCTTCA

TTTATTATATGATGTTCAAGAAGGCCATCGGTGTGTTCAAGAGACTGGAGAACTATAGCC

GGTCTCCTTTATTCTCCCACATCCTCAATTCTCTGCAAGGCCTGAGCTCCATCCATGTCT

ATGGAAAAACTGAAGACTTCATCAGCCAGTTTAAGAGGCTGACTGATGCGCAGAATAACT

ACCTGCTGTTGTTTCTATCTTCCACACGATGGATGGCATTGAGGCTGGAGATCATGACCA

ACCTTGTGACCTTGGCTGTTGCCCTGTTCGTGGCTTTTGGCATTTCCTCCACCCCCTACT

CCTTTAAAGTCATGGCTGTCAACATCGTGCTGCAGCTGGCGTCCAGCTTCCAGGCCACTG

CCCGGATTGGCTTGGAGACAGAGGCACAGTTCACGGCTGTAGAGAGGATACTGCAGTACA

TGAAGATGTGTGTCTCGGAAGCTCCTTTACACATGGAAGGCACAAGTTGTCCCCAGGGGT

GGCCACAGCATGGGGAAATCATATTTCAGGATTATCACATGAAATACAGAGACAACACAC

CCACCGTGCTTCACGGCATCAACCTGACCATCCGCGGCCACGAAGTGGTGGGCATCGTGG

GAAGGACGGGCTCTGTAGGTTTTTACTGAGCACCTACTATGTGCCTGGGAACCGAAAGGG

AAGTCCTCCTTGGGCATGGCTCTCTTCCGCCTGGTGGAGCCCATGGCAGGCCGGATTCTC

ATTGACGGCGTGGACATTTGCAGCATCGGCCTGGAGGACTTGCGGTCCAAGCTCTCAGTG

ATCCCTCAAGATCCAGTGCTGCTCTCAGGAACCATCAGATTCAACCTAGATCCCTTTGAC

CGTCACACTGACCAGCAGATCTGGGATGCCTTGGAGAGGACATTCCTGACCAAGGCCATC

TCAAAGTTCCCCAAAAAGCTGCATACAGATGTGGTGGAAAACGGTGGAAACTTCTCTGTG

GGGGAGAGGCAGCTGCTCTGCATTGCCAGGGCTGTGCTTCGCAACTCCAAGATCATCCTT

ATCGATGAAGCCACAGCCTCCATTGACATGGAGACAGACACCCTGATCCAGCGCACAATC

CGTGAAGCCTTCCAGGGCTGCACCGTGCTCGTCATTGCCCACCGTGTCACCACTGTGCTG

AACTGTGACCACATCCTGGTTATGGGCAATGGGAAGGTGGTAGAATTTGATCGGCCGGAG

GTACTGCGGAAGAAGCCTGGGTCATTGTTCGCAGCCCTCATGGCCACAGCCACTTCTTCA

CTGAGATAAGGAGATGTGGAGACTTCATGGAGGCTGGCAGCTGAGCTCAGAGGTTCACAC

AGGTGCAGCTTCGAGGCCCACAGTCTGCGACCTTCTTGTTTGGAGATGAGAACTTCTCCT

GGAAGCAGGGGTAAATGTAGGGGGGGTGGGGATTGCTGGATGGAAACCCTGGAATAGGCT

ACTTGATGGCTCTCAAGACCTTAGAACCCCAGAACCATCTAAGACATGGGATTCAGTGAT

CATGTGGTTCTCCTTTTAACTTACATGCTGAATAATTTTATAATAAGGTAAAAGCTTATA

GTTTTCTGATCTGTGTTAGAAGTGTTGCAAATGCTGTACTGACTTTGTAAAATATAAAAC

TAAGGAAAACTCAAAAAAAAAAAA

M92432

CCCACAGGGGGACCGGCCCTGTGACCCCTCACCGGGGCCGTGGGCCCGAGCCCCGGACTT

CCCTAAGCCGGCAATGACCGCCTGCGCCCGCCGAGCGGGTGGGCTTCCGGACCCCGGGCT

CTGCGGTCCCGCGTGGTGGGCTCCGTCCCTGCCCCGCCTCCCCCGGGCCCTGCCCCGGCT

CCCGCTCCTGCTGCTCCTGCTTCTGCTGCAGCCCCCCGCCCTCTCCGCCGTGTTCACGGT

GGGGGTCCTGGGCCCCTGGGCTTGCGACCCCATCTTCTCTCGGGCTCGCCCGGACCTGGC

CGCCCGCCTGGCCGCCGCCCGCCTGAACCGCGACCCCGGCCTGGCAGGCGGTCCCCGCTT

CGAGGTAGCGCTGCTGCCCGAGCCTTGCCGGACGCCGGGCTCGCTGGGGGCCGTGTCCTC

CGCGCTGGCCCGCGTGTCGGGCCTCGTGGGTCCGGTGAACCCTGCGGCCTGCCGGCCAGC

CGAGCTGCTCGCCGAAGAAGCCGGGATCGCGCTGGTGCCCTGGGGCTGCCCCTGGACGCA

GGCGGAGGGCACCACGGCCCCTGCCGTGACCCCCGCCGCGGATGCCCTCTACGCCCTGCT

TCGCGCATTCGGCTGGGCGCGCGTGGCCCTGGTCACCGCCCCCCAGGACCTGTGGGTGGA

GGCGGGACGCTCACTGTCCACGGCACTCAGGGCCCGGGGGCTGCCTGTCGCCTCCGTGAC

TTCCATGGAGCCCTTGGACCTGTCTGGAGCCCGGGAGGCCCTGAGGAAGGTTCGGGACGG

GCCCAGGGTCACAGCAGTGATCATGGTGATGCACTCGGTGCTGCTGGGTGGCGAGGAGCA

GCGCTACCTCCTGGAGGCCGCAGAGGAGCTGGGCCTGACCGATGGCTCCCTGGTCTTCCT

GCCCTTCGACACGATCCACTACGCCTTGTCCCCAGGCCCGGAGGCCTTGGCCGCACTCGC

CAACAGCTCCCAGCTTCGCAGGGCCCACGATGCCGTGCTCACCCTCACGCGCCACTGTCC

CTCTGAAGGCAGCGTGCTGGACAGCCTGCGCAGGGCTCAAGAGCGCCGCGAGCTGCCCTC

TGACCTCAATCTGCAGCAGGTCTCCCCACTCTTTGGCACCATCTATGACGCGGTCTTCTT

GCTGGCAAGGGGCGTGGCAGAAGCGCGGGCTGCCGCAGGTGGCAGATGGGTGTCCGGAGC

AGCTGTGGCCCGCCACATCCGGGATGCGCAGGTCCCTGGCTTCTGCGGGGACCTAGGAGG

AGACGAGGAGCCCCCATTCGTGCTGCTAGACACGGACGCGGCGGGAGACCGGCTTTTTGC

CACATACATGCTGGATCCTGCCCGGGGCTCCTTCCTCTCCGCCGGTACCCGGATGCACTT

CCCGCGTGGGGGATCAGCACCCGGACCTGACCCCTCGTGCTGGTTCGATCCAAACAACAT

CTGCGGTGGAGGACTGGAGCCGGGCCTCGTCTTTCTTGGCTTCCTCCTGGTGGTTGGGAT

GGGGCTGGCTGGGGCCTTCCTGGCCCATTATGTGAGGCACCGGCTACTTCACATGCAAAT

GGTCTCCGGCCCCAACAAGATCATCCTGACCGTGGACGACATCACCTTTCTCCACCCACA

TGGGGGCACCTCTCGAAAGGTGGCCCAGGGGAGTCGATCAAGTCTGGGTGCCCGCAGCAT

GTCAGACATTCGCAGCGGCCCCAGCCAACACTTGGACAGCCCCAACATTGGTGTCTATGA

GGGAGACAGGGTTTGGCTGAAGAAATTCCCAGGGGATCAGCACATAGCTATCCGCCCAGC

AACCAAGACGGCCTTCTCCAAGCTCCAGGAGCTCCGGCATGAGAACGTGGCCCTCTACCT

GGGGCTTTTCCTGGCTCGGGGAGCAGAAGGCCCTGCGGCCCTCTGGGAGGGCAACCTGGC

TGTGGTCTCAGAGCACTGCACGCGGGGCTCTCTTCAGGACCTCCTCGCTCAGAGAGAAAT

AAAGCTGGACTGGATGTTCAAGTCCTCCCTCCTGCTGGACCTTATCAAGGGAATAAGGTA

TCTGCACCATCGAGGCGTGGCTCATGGGCGGCTGAAGTCACGGAACTGCATAGTGGATGG

CAGATTCGTACTCAAGATCACTGACCACGGCCACGGGAGACTGCTGGAAGCACAGAAGGT

GCTACCGGAGCCTCCCAGAGCGGAGGACCAGCTGTGGACAGCCCCGGAGCTGCTTAGGGA

CCCAGCCCTGGAGCGCCGGGGAACGCTGGCCGGCGACGTCTTTAGCTTGGCCATCATCAT

GCAAGAAGTAGTGTGCCGCAGTGCCCCTTATGCCATGCTGGAGCTCACTCCCGAGGAAGT

GGTGCAGAGGGTGCGGAGCCCCCCTCCACTGTGTCGGCCCTTGGTGTCCATGGACCAGGC

ACCTGTCGAGTGTATCCTCCTGATGAAGCAGTGCTGGGCAGAGCAGCCGGAACTTCGGCC

CTCCATGGACCACACCTTCGACCTGTTCAAGAACATCAACAAGGGCCGGAAGACGAACAT

CATTGACTCGATGCTTCGGATGCTGGAGCAGTACTCTAGTAACCTGGAGGATCTGATCCG

GGAGCGCACGGAGGAGCTGGAGCTGGAAAAGCAGAAGACAGACCGGCTGCTTACACAGAT

GCTGCCTCCGTCTGTGGCTGAGGCCTTGAAGACGGGGACACCAGTGGAGCCCGAGTACTT

TGAGCAAGTGACACTGTACTTTAGTGACATTGTGGGCTTCACCACCATCTCTGCCATGAG

TGAGCCCATTGAGGTTGTGGACCTGCTCAACGATCTCTACACACTCTTTGATGCCATCAT

TGGTTCCCACGATGTCTACAAGGTGGAGACAATAGGGGACGCCTATATGGTGGCCTCGGG

GCTGCCCCAGCGGAATGGGCAGCGACACGCGGCAGAGATCGCCAACATGTCACTGGACAT

CCTCAGTGCCGTGGGCACTTTCCGCATGCGCCATATGCCTGAGGTTCCCGTGCGCATCCG

CATAGGCCTGCACTCGGGTCCATGCGTGGCAGGCGTGGTGGGCCTCACCATGCCGCGGTA

CTGCCTGTTTGGGGACACGGTCAACACCGCCTCGCGCATGGAGTCCACCGGGCTGCCTTA

CCGCATCCACGTGAACTTGAGCACTGTGGGGATTCTCCGTGCTCTGGACTCGGGCTACCA

GGTGGAGCTGCGAGGCCGCACGGAGCTGAAGGGCAAGGGCGCCGAGGACACTTTCTGGCT

AGTGGGCAGACGCGGCTTCAACAAGCCCATCCCCAAACCGCCTGACCTGCAACCGGGGTC

CAGCAACCACGGCATCAGCCTGCAGGAGATCCCACCCGAGCGGCGACGGAAGCTGGAGAA

GGCGCGGCCGGGCCAGTTCTCTTGAGAAGTGAGGCCCGGCCCCGGACAGGGTCTGGGCCC

TGCTCCCTGTCCCATCTGCAGTGGACCCCAGGCACCCCCCTTTGAGGAGGTGGGGTGAAC

TGCTCCTTGGCAGGGATTTGTGACACTGCATTGCTGGGCTGTGTTCCTCGGGCTCTTCTG

GACCTTGCACCpTGGATACCAGGCCATGTGCCATGGTATTTGGGTCCTGGGAGGGTGGGT

GAAATAAAGGCATACTGTCTT

AL050227

CTTTCACAGAAAGAAAGTAACAGGCATAATTCCTGTTGATGAGGCTGGGATTGTTTTTAA

GAGGAGAGATAATAACTTCATATTTTTAAAGTGCCAGTAGCCTAATATGTGAAACAGATC

AGAATCTGTTGTGTAGTAAGTCTGCTTTGTTGAAGAATTTATTATGGGAGTAAAGATAAG

AAGGAAAGAGATCACCATCAGAAACAAGTCAGCCTTTTCATGCTTTTTTGAGCATTTTTG

GAGATGATTCCACTTCTCAAGTTATTATCATTTGTGCATCTCTTCAATGCTATTGTTAAA

TGCTTTAGAATTAGAATATTTTGATCCTTTAATTAAAGTAAGCCAAACGTCTAGGCAAAA

ACAGCCAATCATTAAACTTTAATAGTAATTCAAATATAGATTTCTCATACAGTTTTCCAT

GTCTGTAGAAATCAAAGTTGTAATGTTAAGCAGAGGGAAATGCGTGTGATTTACTAATAC

ACTTCAACGTTCTACTTTTGAAAGGATACTCATGTGGGTGGGGCAGAGAACATAGAAAAA

GATATGATGGAAAACCTGTCCATTTTCTACCTGTTAACCTTCATCATTTTGTGCAGGCCC

TGGAAGCAAAGAGAGGAAGGGACCGACTGCATTTATCTTTGAACACTTGAGCATCAGTAG

TACTACTGAGTGGCCAGGGGTCTTGTCTGTCAAAGCAAATGATAAGTTCACTCAGGCCAT

TATTGACTGCTGAACTCTCTTCCTTCCCAACTCTTCCTTGAAAGAGAAAAAAATACTTTG

CCTTCTTGCTCTCCTTATCAAATGTTTTTGTACAAATAGTGTAAGCCTGTTTAAGCAAAC

CAATTAAAATAGGCACTGATTATTTTGATCTGTTTGTAACAAATGAATGTAAGTACTATT

TACATGGTGTGCCTAGGAGGAGCTGAAATCATTGGCACTTTAATCCATATTGTAAAGATC

AGTATCAAAAGCATAGTGTTCTTCACCTCTCCTCCTCAGCATCCATCTCTATATACTTGA

TTAAATGGAAAAGTCTCTTTTATCACCTCTATGTAAAGTTTTATGGGTAGTTATCGTCAG

TGTATTTAAATATATCTTCTAGTATGTTTTAAAGGCTGGTCTTCAATACTGTGGAGACAA

AAAATAAAAGAGCGTATGAAAAGTACGTTAGACTTTTGCTGGCATTCAAGTCATGGCTAG

TCTGTGTATTTAATAAATGTGTGTTATTTATGTCGTGTTTGTCAATGGAAAATAAAGTTG

AATATTCTGAAAAAAAAAAAAAAA

AW613732 (IMAGE Clone ID: 2953502)

CCTANAAGTNCCATTTTGGCAAGGATAAACTCCCATGACAANCTCCCANTACTGCATGTG

AATGAATAAGAAACAAGAANTGACCACACCAAAGCCTCCCTGGCTGGTGTTACANGGGAT

CAGGTCCACAGTGGTGCAGATTCAACCACCACCCAGGGAGTGCTTGCAGACTCTGCATAG

ATGTTGCTGCATGCGTCCCATGTGCCTGTCAGAATGGCAGTGTTTAATTCTCTTGAAAGA

AAGTTATTTGCTCACTATCCCCAGCCTCAAGGAGCCAAGGAAGAGTCATTCACATGGAAG

GTCCGGGACTGGTCAGCCACTCTGACTTTTCTACCACATTAAATTCTCCATTACATCTCA

CTATTGGTAATGGCTTAAGTGTAAAGAGCCATGATGTGTATATTAAGCTATGTGCCACAT

ATTTATTTTTAGACTCTCCACAGCATTCATGTCAATATGGGATTAATGCCTAAACTTTGT

AAATATTGTACAGTTTGTAAATCAATGAATAAAGGTTTTGAGTGTAAAAAAAAAAAAAAA

AAAAAAA

BC007783 (IMAGE Clone ID: 4308472)

GGCACGAGGGCAAAGAGTAGTCAGTCCCTTCTTGGCTCTGCTGACACTCGAGCCCACATT

CCATCACCTGCTCCCAATCATGCAGGTCTCCACTGCTGCCCTTGCCGTCCTCCTCTGCAC

CATGGCTCTCTGCAACCAGGTCCTCTCTGCACCACTTGCTGCTGACACGCCGACCGCCTG

CTGCTTCAGCTACACCTCCCGGCAGATTCCACAGAATTTCATAGCTGACTACTTTGAGAC

GAGCAGCCAGTGCTCCAAGCCCAGTGTCATCTTCCTAACCAAGAGAGGCCGGCAGGTCTG

TGCTGACCCCAGTGAGGAGTGGGTCCAGAAATACGTCAGTGACCTGGAGCCGAGTGCCTG

AGGGGTCCAGAAGCTTCGAGGCCCAGCGACCTCAGTGGGCCCAGTGGGGAGGAGCAGGAG

CCTGAGCCTTGGGAACATGCGTGTGACCTCCACAGCTACCTCTTCTATGGACTGGTTATT

GCCAAACAGCCACACTGTGGGACTCTTCTTAACTTAAATTTTAATTTATTTATACTATTT

AGTTTTTATAATTTATTTTTGATTTCACAGTGTGTTTGTGATTGTTTGCTCTGAGAGTTC

CCCCTGTCCCCTCCACCTTCCCTCACAGTGTGTCTGGTGACAACCGAGTGGCTGTCATCG

GCCTGTGTAGGCAGTCATGGCACCAAAGCCACCAGACTGACAAATGTGTATCAGATGCTT

TTGTTCAGGGCTGTGATCGGCCTGGGGAAATAATAAAGATGTTCTTTTAAACGGTAAAAA

AAAA

X81896

AGAAAACTATTTTCTAAATATTAACACTGAAAATGTTTTGTTAGCTTTTCCTTCTTTCTC

TCCAGAAGAAACATGGATAGATGATAGCTGTTTCATTGTTTGTTTTTGTCAAGCATATTC

ACTTTCCTCCTTGTCCTCTGATTCTGAGCAAAGGGCCTCAGACTCTGAACTTCCCTCAAG

TGCCGTTGTTATGTGAACTCTTCCATTCAGATTCCAGAGAGGTTCTCATGCTCCCCCCCC

CTCCTTATTTGTAGCAATCGTAGCAACTAATTCCACTAAGTACAAGGGAGTTTTTTACAC

TCCTCCATTTTTATAGCATCTGCATTTTTTTTTTTTGTTAGGTACATGTATACACCTGCC

TGAGTATAAATACTCTCTCTACCTAATAATAACATCAACCAACATCTTTTCCAAATTAGG

GCCACAGAACAGCAACATTTGTCTGACAGTAGTATAAAGAATAATGATAGCTCTATCCTT

AAGAAGTATTTCCTTTCCTTTTTATATAGTCCCGTTAGGGTTTAAAACCATATTGATCAA

CTAGAAAGAAAAATATGAAAAGAGAAAAATATTTTAATTTAAAAATTGTAATACATTGAT

TTATAAAATGCCTTCTCTGATACTTTTGAAACAGATGTGAAAAACAGAAAAAGAAAAAAT

TGTCTGAAATGTTTATTTTGCAAAACAGTGCAATAGAATCTAGTTATGCCTTCATCACTG

TTGACAGTAAATACTGACAGCCCCTTGCAGTGTGTTAGTTTTAGATCACTCTGTTTTAGT

TGAGAGAAATGTTTTATATCATGGTTTTTATATGAATACAAATTATTTCTCAAAGATTTA

TAGCACACACTATTCTCAGGAATTCTGTATTACATGAATGCTGCTTATATATTTTCATAT

TCTAACTTGTCTTTTCAAGCAAATAACTAATATATATGTGCATGCAGTCTGCCTTGACAA

GTTGTTCCAAGCTGAAGAGCTTTCACTGTACAATGTGTGGAAAATCACCATAGATCATGG

CTGAAATAGTTTGTAATTGTCTGAGTCTGTGCACGTACTTTTAGATAAAATGCTGCTGAG

TGACTGCATGATGAGATACAACTTCTGAATGCTGCACATTCTTCCAAAATGATCCTTAGC

ACAATCTATTGTATGATGGAATGAATAGAAAACTTTTTCACTCAATAAATTATTATTTGA

TATGGTAAAAAAAAAA

BC004960 (IMAGE Clone ID: 3632495)

CCCAAGGTTGTTATATCTTCATGTCCTCATTTCTTAGGGAGGTACCTTCAGAACCAATAG

TGACCCCTAACTTCTCTGGTGGTCGGTTCCATGAAAGGCAAAGGAGTGTGAGAGAGGAGT

GGATGGTCAACCTCCCACTGCCATGGTAACATGGGTGCTGGCTGATGGGAGCAGAAAATA

ATTTAGTGAAAGTCTGTGGGGGCAGTCACAAGATGTCTGAGAAAACTGGCGAGCCAGCTG

CTGAAAACAGGGACAAGGAAGCCTCCGTGGCTGGAGCCCAAATCACACTGCAGACCCAGA

CACCGTGACCACCACCATGGACTCCAGAGAGAGCAGCTTATAGTACTCAATCAGCTGCCA

CTACCACCATCCAGAACACCAGATGTTGTAGCCATGGCTGCAGCAGGAATGGATGTCCCA

CTGTCCCTGCTCCTCGGTGTGACTTGCTCCCAAGTTCAGGGCAGGTCCATCTGATTGGCT

GAGTCTGGAATGTCTGCCTGTGCCTCAGCTGTGAGGGAGGCAGGGAAAGTAAGCCTTTTC

AGCTTCTGTCGTGGGAGGTGGGCTCTGCCTCCTACCAAGAATCAAAGGGTGGAGGATCTT

CAAACACAGGAAAAGAACCCGGATCCTGGCACCCCCAAATTTTCAGAGTCCATTTCAGAG

CATAAGAAATTGAGGGTCCAAGATCATTCATGTAAGAAGTTTAGAGGGGGAAGAAAAGAA

TGATAAACGAAAAGAACAGCAATAGTAAAGGATCTTTTCTTTGTTTCAGTAAGATGAAGA

GGCCTGAGCAGTTTCGTGGAGGGGAAGAAACAGGAAAACCTCTTCAAAAGACAAAAAGCT

GGCACTGCATTCTCTCTCTGTAGCAGGACAGAACTGTCTAAAGACAAGACCCCTTTGGCC

AAAATAAAGGAACCTGAAACATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAAAAAAAAAAACCTCGGG

AK027250

AAATTTAATTAATTATAAACTCAGTCTCTTGGTTGCACCAGCCACATTTCAGATGCTCAA

TAGCCACATGTGGCTAGTGGGTACCATATTGGACAGGGCAGCTATAGAATATTTCCATCA

TTGCAGAAAGTTCTATTGGATAGTACCATAATCTTTTTATAGTAACTTGGAAATACTATT

TGATATTAGATGTTAGACCACAAAAAGAAGAAAAATGTTAGGACTATTTCAGATATAAAA

AGGAACTGAATTGTGACATAATTAGCATCTTACATTCCATACAGTTGAATACCTTATGCT

GTGACAACCATAGTTAATCATTTCAGTGCTGTTCAACATACATACCTATCAGCAGTGTGT

TTAGACCAGGGGTCTGCAAACTTTCTGTGAATGGACAAAGAGTAAATACTTTAGTAAATG

TCTTAGGCTTTGTGGCCTACATGATCTTTGTTGCAAGTACTCAACTCTGCCATTATAGAG

TTAAAGCAGCCATACACAATATATAAACAAAATGGGCATAGTTGTATTTCAGTAAAACTT

TATTTACAAAGACAGGCGGTAGGCCAGATTTGGCTTGCATGCTGTAGAGCTGTGGTCTAA

ATTTTATTCATAGACTTTCTTTGCAAATACAGTGTGAGTATTGTTCCATTTACAGTATTA

TTATTTTTTAGATACCTGGTTTTTAGATTCTTGCCTGGTAACTTTTTACTGAAAATACAA

GAATTTCGTACTGCATTTGCATCTCCGAGATTAGGGAGCACCTGTCAGGATATGTTGTTC

TATCAGGGTTACTTCTGTTGACTACCTCTTAGATTTTGATACAGTTATATTGTTGAGTTT

CATTTTCATATATTCTTGTAGTGTCTGCTTGCCTGTGACTTCTGGTAAAATAAAATAAGC

CTTTGAAAATATTTTAGCATGGTATTTAACATTTTCTAAATATTATGGCATTTTGACATA

TTTTAGTCAGCGAAGACATCTGCCCCTTTGGTGTTTCTACTTGCTTATGATTGAGATTTT

ACAAGCCCTTCAAACTCCGTTTTAAAGGAATTTATTGTAAAACATTAACTTTAATAAATT

AGTGTTTTCACAGATCAGATCATTATACTTGGAACTTCTAAATCATGCAATTTCTGAATA

AGGACATAAGGCTAGATTCATTTTTCTTAATAGAGAAAAAGGAAATTTCTGATTTATCAC

TTTTCTAGTTGATAAGTAGGATTCAAAACGTTTGATATGTAAGTATTTATATAAGACTAA

TGTAATTTAAAGTTCTGTATTATTGTGATTAATCATACAGAAATTCAGGAACTGATCAGA

AGTGAGATTCTTTTCCACATCTGGTTAATGTAGTGAGTTGACACCCTGTGGGTGGTAAAG

CATTATAAACATTTCATCTTGAACCATGATTTATACACATCTGTGTTATAAGGGAGGCTT

GAGTACATATACCAATGAAGAGATATTCAGCATTTGTCTATTTGATAAGGAATTAAATGT

CCTAGTGATTATAAAGTAAAACCACAGACCAATTTGCAAATGATCTTCAATGTTAAGCAC

TTGCTCTAAGATTAAAATTCCTTTTCTTTTTAAGGTTAAGGGTGTGTACGTATGGCAGTG

ATGTCTATGTTGAGATTAACTTATGTATTGAGGAAAATTTGAAGTTTATTTTTTCGATGA

ATAAGGCTGTCAAATGATTTAGTATAGATTAATGACATCTTTTTTAGAAATATTAAAGTG

AGTATTCCTCATTATGTCATCATTTCTGATAATTAGAGTGCTAATTTGAATGTTAGATAA

TGTTTCCACATCTATACCTATTTCTTTCTAGGGCACTTCTGACCCTGGGGCTTGGGGATG

GCCTTTAGGCCACAGTAGTGTCTGTGTTAAGTTCACTAAATGTGTATTTAATGAGAAACA

TTCCTATGTAAAAATGTGTGTATGTGAACGTATGCATACATTTTTATTGTGCACCTGTAC

ATTGTGAAGAAGTAGTTTGGAAATTTGTAAAGCACAAACCATAAAAGAGTGTGGAGTTAT

TAAATGATGTAGCACAAATGTAATGTTTAGCTTATAAAAGGTCCTTTCTATTTTCTATGG

CAAAGACTTTGACACTTGAAAAATAAAACCAATATTTGATTTATTTTTGTAAGTATTTAG

GATATTATTTTAAATAAATGATTGTCCATTATCAATAAAAAAAAAAAAAAAAAA

Sequences from Table 5 not disclosed above

NM_014298

GTCCTGAGCAGCCAACACACCAGCCCAGACAGCTGCAAGTCACCATGGACGCTGAAGGCC

TGGCGCTGCTGCTGCCGCCCGTCACCCTGGCAGCCCTGGTGGACAGCTGGCTCCGAGAGG

ACTGCCCAGGGCTCAACTACGCAGCCTTGGTCAGCGGGGCAGGCCCCTCGCAGGCGGCGC

TGTGGGCCAAATCCCCTGGGGTACTGGCAGGGCAGCCTTTCTTCGATGCCATATTTACCC

AACTCAACTGCCAAGTCTCCTGGTTCCTCCCCGAGGGATCGAAGCTGGTGCCGGTGGCCA

GAGTGGCCGAGGTCCGGGGCCCTGCCCACTGCCTGCTGCTGGGGGAACGGGTGGCCCTCA

ACACGCTGGCCCGCTGCAGTGGCATTGCCAGTGCTGCCGCCGCTGCAGTGGAGGCCGCCA

GGGGGGCCGGCTGGACTGGGCACGTGGCAGGCACGAGGAAGACCACGCCAGGCTTCCGGC

TGGTGGAGAAGTATGGGCTCCTGGTGGGCGGGGCCGCCTCGCACCGCTACGACCTGGGAG

GGCTGGTGATGTTGAAGGATAACCATGTGGTGCCCCCCGGTGGCGTGGAGAAGGCGGTGC

GGGCGGCCAGACAGGCGGCTGACTTCGCTCTGAAGGTGGAAGTGGAATGCAGCAGCCTGC

AGGAGGTCGTCCAGGCAGCTGAGGCTGGCGCCGACCTTGTCCTGCTGGACAACTTCAAGC

CAGAGGAGCTGCACCCCACGGCCACCGCGCTGAAGGCCCAGTTCCCGAGTGTGGCTGTGG

AAGCCAGTGGGGGCATCACCCTGGACAACCTCCCCCAGTTCTGCGGGCCGCACATAGACG

TCATCTCCATGGGGATGCTGACCCAGGCGGTCCCAGCCCTTGATTTCTCCCTCAAGCTGT

TTGCCAAAGAGGTGGCTCCAGTGCCCAAAATCCACTAGTCCTAAACCGGAAGAGGATGAC

ACCGGCCATGGGTTAACGTGGCTCCTCAGGACCCTCTGGGTCACACATCTTTAGGGTCAG

TGAACAATGGGGCACATTTGGCACTAGCTTGAGCCCAACTCTGGCTCTGCCACCTGCTGC

TCCTGTGACCTGTCAGGGCTGACTTCACCTCTGCTCATCTCAGTTTCCTAATCTGTAAAA

TGGGTCTAATAAAGGATCAACC

AF033199

CGGGGCATGCTGCTTCCCTTCACCTTCCACCATGATTGTAAGTTTCCTGAGGCCTCCCCA

GGTGTGCTTCTGTACAGCCTGTGGAATGTTACCAAAGACGTTGGAAGAGGTGGCTATGGG

ACATCACCTGGGAGAAGTGGAAGCAAATGGACACTGTTCAGAAGTCCATATACAGAAACA

TACTTGGAAAAATATAGAAACCTGGTTTTGCTAGATGGGAAGCTTGCAGCTGGGGCCAAG

ACATCAAGAGTAGAGCAGCAGGACATTTCAAAAGAAGATTAACTCAAAGATTAGAGATGG

AAGAACTTGCAAAGAGAAAGTCTGTACCGGAAGAAATCTGGAAATCTAGAGGCCAGTTTA

AGAATCAGCAGCTAAACAAGGAGAATAATCTAGGGCAAGAGATAGCTACCTGCACAAAAA

TTCCTACCAGAAAAAGAGACATAGAATCTAATGAATTTGTGAAAAATTTTACTGTAAGAT

CAATACTTGTTGCAGAACAGATAGATCCTATGGAAGAGAATTGTCATAAATATGGTACAT

GTTGAAAGATGCTCAAACAAAACTCAGATTTAATTATACAAAGAAAGTATGATGGAAAAA

AAAAAACCTTGTAAATATAGTGAATGTGGGAGAACCTTCAGAGGCCACATCACTCTTGTT

CAGCATCAAATAACTCATTGTGGAGAGAGACCCTGTAAATGTACTGAGTGTAGAAAGGGA

TTTAATCAGAGTTCCCACTTAAGAAATAATCAGAGAAAAACTCTTTCAGGAGAAAAGCCC

TACAAATGCAGTGAGTGTGGGAAGGCCTTCAGTTATTGCTTAGTTCTTAATCAACACCAG

AGAATTCACAGTGGAGAGAAACCTTATGAGGGTACTGAATGTGGCAAGACATTCATTCAG

TCGTACATACCTTACTCAGCATCAAAGAATTCACACACTGGTGAGAAGCCCTATACATGT

CTTGAATGTGGAAGGCTTTTTAGTCAGAACACACATCTTACTCTACATCAGAGAATCCAT

ACTGGAGAGAAACCTTATGAATGCAATGAATGTGGTAGGTCCTTTAGTCAGACTGCACAT

CTTACTCAACATCAAAGAATGTATACAGGAGAAAAACTCTATGAATGTAATGAATGTGAG

AAAGCCTTCCATGATCACTCAGCTCTTATTCAACATCATATTGTCCATACTGCAGAGAAA

CCCTATGATATCATGACTGGGAAAACTTTCAGTTACTGTTCAGACCTCATTCAACATCAG

AGAATGCACACTGGAGAGAAACCATACAAATGCAATGAATGTGGGAATGCCTTTAGTGAT

TGTTCATCCCTTATTCAGCATCAAAGAACTCACACTGGAGAAGAGCCTTATGAATGTAAG

CAATGTGGAAAAGCCTTTAGCAGAAGCACATACCTTACTCAACATCAGAGAAGTCACGCA

GGAGAGAAACAGTATAAATGCAATGAATGTGAGAAAACTTTCAGCCTGAGTTCATTCCTT

ACACAGCATATGAGGGTTCAGACTGGAGAAAAACCCTACAAATATAATGAATATGGAAAA

GCTTTTAGTGACTGCTCAGGACATTTTCAGAGAACTCACACTGGAGAGAAGCCCTGTGAA

TGTAATGACTGTGGGAAACCTTTCAGTTTCTGTTCAGCCCTAATTCAACATAAGAGAATT

CATACCAGAAAGAAGCCCTGACTGTACCTTCATACCAGTAAATGCACTGACTGTGGAAAA

GCCTTCAGTGATTGGTTAGCACTTGTTCAACATCAGATAACTCAACACTGGAGAAAAACC

GTATAAATGTACTGAATGTGGAAAAGCCTTCAGTTGGAGTACAGACCTCAAAAATCACCA

GAAAACTCATACTAGTGAAAAATCCTATAAATGTAATGAATGTAGAAAGGCCTTTAGTTA

CTGCTCTGGTCTTATTCAATGTCAGGTCATTCATACTATAGAAAAACCTTATGAATACGG

TAAATGTGGCAAAGCCTTTAGGCAGAGGACAGACCTTAAAAAACATCAGAAAATGCATAC

CGAAGAGAAACCCTATGAATGTAATGAATGTGGGAAAGCCTTTAGCCAGAGCACATATCT

TACAAAACACCAAAAAATTCATAGTGAAGAGAAATCAAATATACATACTGAGTGTGGGGA

AACCATTAGACAAAACTCTTCTTTTTACAACAATAAAACCTCACACTGGAGAGTTCTCTG

AATGCCTTAAGAATTTGGTTAATATGGAGACCCTTCCCAGGGAAACAGAAGGAGGATCGT

GAAAACCGTTGACTACTTGAATGATCACATGGTTTAGTGGAGAGAGCATGATTCTGGGTT

TTAAAAGTCATGGATCTCAATCTCAGCTCCTATTACTAACTAGATCTTTTACTTTGGGGT

AAGTCACTTCATATCTTTAGGCCTTAATTTCCTCATCTGAAAACTGGAAGGCCTGACTTG

ACTTGTTGAGCTTAAGATCCTCAATTATTATATTTACTAGGAATTCAAGTTTCTATAGAT

GTGGTTCAGAATTGTGACTTATTTATTGTACATCAGGTGTGATTCACAAGTGAGCTTGTA

GTAGTTATTAAGGAGTCAATAAAGATATGATATAAAAAAAAAAAAAAAAA

AI688494 (IMAGE Clone ID: 2330499)

CATTTCATCTTCATTGGATAGTGTTACATAGTAATATATTTATGTTTTCTTTTAATCATT

TCATAACTTGGAAAATACTAACATAGTCAAAACTCTAGGGTAGGTGATACATGAGTTTCT

GTAGTAATCTGGTTGGAGACATGTTGTAATTCTGTATATATATGTACATTTATCCCATGC

ATGTTATGCCTAAACTAAGACGGATACCCCTGAATTAAGAGGTGCTGTTATACATTGACC

AGGCTTAAGAATATCTCTTTAAAGTGTGTCGACATTTAATTGACCTTTGGAAGTTCATTC

TGTTAATCATACTCAAAGTGCTAAAGCTATGGTTGACTGCTCTGGTGTTTTTATATTCAT

TCGTGCTTTAGCATATAAATTCTTCAGCATAATTGCTACTTATTTAGCAAGAGTTTCCTT

TATTTGAAAATGTGAGTTGTGCTTGTATTTTTGTGTCTTTCTTTCTTTCTTTCTTTTTTT

AAACTTTGCTTCAGGCTGGGTAGTGGTAGAGGTTTGAATTAAAATGTTTTCCTGTCAGTA

AAAAAAAAAAA

AL157459

GAGCGAGCCCAGCAGCTTGCCCTTGACAGGTGGGGGCTGGCTGGGGCCTTAATGTGAAAA

GACAGTGGCAGGCAGCTGGAGTAGAGCGAGCCCAGCAGCCCTAAAAGGCTGCCTTCATGG

CCATCTAGCCCCAGTTCAGGGCAGCATCCATAGCCCACAAGCCAGCGTGGGTGGGGCGGG

GGTGGTCCCACAGCTGGGTTCCACCTGAAGAGCCTCCGTGCCTCGGAGCAGGAGAGGCAG

GCTATGGCTGTCACCCTCCCTCCTGCCTGTGTCCCAGTGAGAACTGACCTGAGTCCCCTT

CCAAACCCAGACCCACCTCCTGCCCCAGGCCCACTGAAGCATGTTCCATTTCTAAAAAGC

CCAGAGTTCAGTGTGTCCCAAGGAAAACCCAAAGTGGAGGTGCTCAGGTCCAGGGGAGTC

CAGTGGGCAGGACCCTTGGCAGGCAAGCCCCTCCCTTCACTCCCAGGACCTACCTTCTGC

TAGTAAAGGACTGGCTTCATTCTAATTATGGCCCACAGACTGCCCCGGAGACCTGGAGGA

CAGCAGTGCTGGCACTTGGGTGTCCATGGGCCCGTCTGCCGGCTCTGCCTGTGCTGCAAG

TGTTGGCCGTGGGTCCAGCCAACAACTCCCTACGTCCTGTGTGGGGCCCTGCCCAAGTGG

ATGAGGCATTCCTTGAGGAGTATCATTTTCCCTGACAATCCCCATCACCTTTAGGGGTTC

CCTGCTTGGCTCCTTTCCAGCTGAAAAACTAGACCTGTGCCATTGGGGAAGCTGGACAAA

GTCTAGGGGGCCCGCCTGGTAGAGGGTCCCGGGAAGCTGGATCTGTCAGCCTCGGCCCTG

AGGCCCCTGTTAACTCAAGACTGTGAGCTGCCTCTAGGTGGTCACGTCTGGGAGCTAGCT

TGTATGGCTTCTGACCAGTATCAGGATTTCTGTTCTGAGAGCAGCGTGGGCAGCAAGGCA

GGGCAGCCCAGAGGTGGCAGCGGCAGGCAATCTGGTCACTAGGTCTTTGTGATGCCAAAA

ATAAAAGAGGGTGGGGTGGGTGCTTTCTGTTCCTCTGATTGGATGGAGTCCGCCAGCAGG

CATGGGGCTACATTCCAGTGCCTGACTATAGGGAGGCACTCCTGATTCCATGGAGCAGCC

CGGACTTTGAGAATGGGCTCTGGTTTGCGGGGGGCAGGCGTACCAGACTGCAAGACCCCC

CAGTACCTCACCGTGCCAAATAGGAAGAGGTGGCCTTGGTGTAGCCAAATGGATCTTTTT

AACAGTGTGCCTTTGGGGAGGGACCCATGTCCATGGCTTCGTTGAGGGCCATCCATATGC

CAGCTGGGGGCCAGCCCACAGTGGCCATATTGGCTGCAGCAGGAATGGTGCCCACCTCGG

CGAATTGAAGGGCTAAGAGTCCCAGATAGCTAGGCCAGAGCTGGAAGCAGACAGTAAGGG

GAAGAGCTGCTCCCACAGGAGAGGGAGAGATTCCAGCTCACTGCGCAGCCTGGGAGGAGG

CGTGGATCCTGGCACGCTGAGCCTCAGGCACCAGCCTCCCTGTGCTCGACAGCAAAGTCT

TGACTCCTTCCTGCTGAGCACTGTGCTACCTTCACTGCTCCAAAGCCAGACTAACAGCTC

TCCAAGCCCTTGGGGTGACTCGGCTTCCAGGAGCTGTTGGAGAAATGAGGATGTCTGTCC

CTGTCTGCCTGGGCAGGCCAGATTCCTCCCCAGCAGCCGGGTCTCTCCAGACCCTGATTC

GGTGCCTTTCTGTTTACCAGCTACTTCAATCCCAAAGTTTGAATCTGCAGATACCTTACT

CCCAGCCACTTTGCCTTCTTACTGTGTTGTGTGTTTTTCCTGGTGCTTCAAGAGCGTGTG

CAGGGCAAGTGCCGTCACTGGGAACTGCACCAGATGCTCAGACTTGGTTGTCTTATGTTT

ACCAATAAATAAAAGTAGACTTTTTCTATTTTTATTTGCTGCTATTTGTGTGTGTGTTTG

TGTTTGTGTAGCTAGGTATCTGGCACTTCTGACGATGCATTGTTGCTTTTTTCCCGAAGG

TCCCGCAGGAACTGTGGCAATGGTGTGTGTGTGAAATGGTGTGTTAACCGCGTTTTGTTT

GCTCCTGTATTGAATAGGAAGCAGTGGCCAGTCTGTCTTCCTTAGAGATGTTAGCATATT

TTTATATGTATATATTTTGTACCAAAAAAGAGTGTTCCTTGTTTTGGTTACACTCGAAAT

TCTGACCTAGCTGGAGAGGGCTCTGGGCCGAGAGCTTTCACTAAGGGGAGACTTCAGGGG

AGGATCAAGCTTTGAACCAAAGCCAATCACTGGCTTGATTTGTGTTTTTTAATTAAAAAA

AAAATCATTCATGTATGCCACTTCT

BC002480 (IMAGE Clone ID: 3350037)

GGCACGAGGCTGAGACCGGTGCGCCGCGCGCTAGTGGCCGCTCTTCCGCGGGCTAGCGGG

CGGTGGGGGCGCCAGCAGCGCGGAAGGCGGGCACGCGGGCCATGGCTCCCTGGGCGGAGG

CCGAGCACTCGGCGCTGAACCCGCTGCGCGCGGTGTGGCTCACGCTGACCGCCGCCTTCC

TGCTGACCCTACTGCTGCAGCTCCTGCCGCCCGGCCTGCTCCCGGGCTGCGCGATCTTCC

AGGACCTGATCCGCTATGGGAAAACCAAGTGTGGGGAGCCGTCGCGCCCCGCCGCCTGCC

GAGCCTTTGATGTCCCCAAGAGATATTTTTCCCACTTTTATATCATCTCAGTGCTGTGGA

ATGGCTTCCTGCTTTGGTGCCTTACTCAATCTCTGTTCCTGGGAGCACCTTTTCCAAGCT

GGCTTCATGGTTTGCTCAGAATTCTCGGGGCGGCACAGTTCCAGGGAGGGGAGCTGGCAC

TGTCTGCATTCTTAGTGCTAGTATTTCTGTGGCTGCACAGCTTACGAAGACTCTTCGAGT

GCCTCTACGTCAGTGTCTTCTCCAATGTCATGATTCACGTCGTGCAGTACTGTTTTGGAC

TTGTCTATTATGTCCTTGTTGGCCTAACTGTGCTGAGCCAAGTGCCAATGGATGGCAGGA

ATGCCTACATAACAGGGAAAAATCTATTGATGCAAGCACGGTGGTTCCATATTCTTGGGA

TGATGATGTTCATCTGGTCATCTGCCCATCAGTATAAGTGCCATGTTATTCTCGGCAATC

TCAGGAAAAATAAAGCAGGAGTGGTCATTCACTGTAACCACAGGATCCCATTTGGAGACT

GGTTTGAATATGTTTCTTCCCCTAACTACTTAGCAGAGCTGATGATCTACGTTTCCATGG

CCGTCACCTTTGGGTTCCACAACTTAACTTGGTGGCTAGTGGTGACAAATGTCTTCTTTA

ATCAGGCCCTGTCTGCCTTTCTCAGCCACCAATTCTACAAAAGCAAATTTGTCTCTTACC

CGAAGCATAGGAAAGCTTTCCTACCATTTTTGTTTTAAGTTAACCTCAGTCATGAAGAAT

GCAAACCAGGTGATGGTTTCAATGCCTAAGGACAGTGAAGTCTGGAGCCCAAAGTACAGT

TTCAGCAAAGCTGTTTGAAACTCTCCATTCCATTTCTATACCCCACAAGTTTTCACTGAA

TGAGCATGGCAGTGCCACTCAAGAAAATGAATCTCCAAAGTATCTTCAAAGAATAAATAC

TAATGGCAG

Claims

1. An array comprising polynucleotide probes, capable of hybridizing to nucleic acid molecules of one or more of the genes in Table 2 or 3, hybridized to nucleic acids derived from one or more breast cancer cell.

2.-51. (canceled)