US20170065392A1 - Method for producing a prosthesis for reinforcing the abdominal wall - Google Patents
Method for producing a prosthesis for reinforcing the abdominal wall Download PDFInfo
- Publication number
- US20170065392A1 US20170065392A1 US15/357,436 US201615357436A US2017065392A1 US 20170065392 A1 US20170065392 A1 US 20170065392A1 US 201615357436 A US201615357436 A US 201615357436A US 2017065392 A1 US2017065392 A1 US 2017065392A1
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- United States
- Prior art keywords
- implantable prosthesis
- prosthesis
- biocompatible
- base portion
- yarns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
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- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B21/00—Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B21/10—Open-work fabrics
- D04B21/12—Open-work fabrics characterised by thread material
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06B—TREATING TEXTILE MATERIALS USING LIQUIDS, GASES OR VAPOURS
- D06B1/00—Applying liquids, gases or vapours onto textile materials to effect treatment, e.g. washing, dyeing, bleaching, sizing or impregnating
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06C—FINISHING, DRESSING, TENTERING OR STRETCHING TEXTILE FABRICS
- D06C7/00—Heating or cooling textile fabrics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
- A61F2002/0068—Implantable repair or support meshes, e.g. hernia meshes having a special mesh pattern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0052—T-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
- A61F2250/0031—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00161—Carbon; Graphite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00389—The prosthesis being coated or covered with a particular material
- A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
- A61F2310/00982—Coating made of collagen
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2403/00—Details of fabric structure established in the fabric forming process
- D10B2403/01—Surface features
- D10B2403/011—Dissimilar front and back faces
- D10B2403/0112—One smooth surface, e.g. laminated or coated
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2403/00—Details of fabric structure established in the fabric forming process
- D10B2403/01—Surface features
- D10B2403/011—Dissimilar front and back faces
- D10B2403/0113—One surface including hollow piping or integrated straps, e.g. for inserts or mountings
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2403/00—Details of fabric structure established in the fabric forming process
- D10B2403/02—Cross-sectional features
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/08—Hernia repair mesh
Definitions
- the present invention relates to a method for producing a prosthesis for reinforcing an abdominal wall in which an incision has been made, said prosthesis being formed from a T-shaped knitted structure made in one piece.
- the abdominal wall in humans is composed of fat and muscles interconnected by fascias. It sometimes happens that a break in continuity occurs in the fascias, allowing part of the peritoneum to slip through and form a sac, or a hernia, containing either fat or part of the intestines.
- a hernia of this kind can occur on a parietal scar following surgery and is then called an incisional hernia.
- An incisional hernia shows itself in the form of a bulge at the surface of the skin, and its reduction necessitates a further surgical intervention.
- prostheses which comprise, for example, a first sheet of material intended to plug the hernial defect, and a second sheet of material intended to be placed in contact with the viscera, the first and second sheets being substantially perpendicular to each other, such that a transverse cross section of the prosthesis generally forms a T shape, one sheet forming the vertical bar of the T, the other sheet forming the horizontal bar of the T.
- openworked material is understood as meaning that the material has openings or pores at its surface and within its body.
- An openworked material promotes cell recolonization once the prosthesis has been implanted.
- the existing T-shaped prostheses are generally produced from two separate sheets, which are subsequently joined to each other to obtain said T shape.
- the two sheets of material can be joined, for example, by sewing or else by a thermal welding means.
- such joining means may create a weakness of the prosthesis, for example a point of weakness at the join between the two sheets of material.
- the prosthesis is subjected to various pressures and/or tensions, for example by the abdominal cavity or by the muscles of the abdominal wall, which pressures and/or tensions are generated by the movements and/or efforts made by the patient in his or her daily routine. This point of weakness could therefore prove dangerous for the patient in the event of tearing.
- every solution for joining the first sheet of material to the second sheet of material in the existing prostheses by adding a foreign material to the prosthesis or by modifying the chemical structure of the prosthesis by a thermal or mechanical process, is susceptible of creating a discontinuity in the performance of the prosthesis as a whole, and such discontinuity is undesirable.
- the present invention aims to meet this need by making available a prosthesis for reinforcing an abdominal wall in which an incision has been made, said prosthesis comprising a knitted structure made in one piece, said knitted structure comprising a first portion, which is substantially plane and flexible and is intended to be placed between the abdominal wall and the abdominal cavity, and a second portion, which is substantially plane and flexible and is intended to be placed between the two margins of the incision, said second portion extending substantially perpendicularly from one face of said first portion.
- the present invention also relates to a method for producing such a prosthesis, said method comprising the following steps:
- a) producing a knit comprising a base sheet which is substantially plane and elongate and which is equipped in its longitudinal direction with a succession of folds substantially perpendicular to said sheet, by knitting biocompatible yarns on a warp knitting machine, said yarns being distributed on at least three guide bars B1, B2 and B3, said three bars operating according to a defined weave repeat recurring as desired along the production length of the knit, each bar being supplied with a yarn coming from a corresponding warp beam rod at a dedicated run-in appropriate to the movement of said bar in accordance with said weave repeat, at least bar B1 having a variable dedicated run-in D1, the value of said variable dedicated run-in D1 decreasing and tending towards 0 on a part of said weave repeat, the decrease in the value of said run-in D1 on said part of said weave repeat generating a said perpendicular fold,
- step b) cutting from the knit obtained in step a) a knitted structure comprising a part of said base sheet equipped with a perpendicular fold, said part of the base sheet forming said first portion of the prosthesis, and said perpendicular fold forming said second portion of the prosthesis.
- the knitted structure forming the T-shaped skeleton of the prosthesis according to the invention is made in one piece, in particular in one knit, obtained in a single knitting step.
- a knitted structure made in one piece is understood as meaning that said structure is produced in a single knitting step and is not formed from two or more separate pieces that are connected by a joining means, for example sewing, ultrasonic welding, etc.
- the yarns from which it is made present a continuity across the entire surface of the structure.
- the T-shaped skeleton of the prosthesis according to the invention is not obtained by joining two sheets of material.
- the first portion, which is intended to be placed between the abdominal wall and the abdominal cavity, and the second portion, which is intended to be placed between the two margins of the incision are one and the same knit.
- the join between the two portions does not require any connecting means, for example sewing, thermal welding, etc.
- it is the same yarns that form both the base sheet of the knit, in other words the first portion of the prosthesis, and also the perpendicular folds of the knit, in other words the second portion of the prosthesis.
- plane and flexible portion is understood as meaning that said portion has the general form of a plane textile and that it can be manipulated and deformed easily, for example in order to fold it back on itself at the time of introduction of the prosthesis into the body of a patient.
- the knitted structure is formed from biocompatible yarns that have a rigidity necessary for maintaining the T shape of said knitted structure, that is to say for maintaining the perpendicular position of the second portion with respect to the first portion, in the absence of any stress exerted on a portion of said structure.
- the production method according to the invention makes it possible to produce a knitted structure of which the transverse cross section has the overall shape of a T, without creating discontinuity between the first portion (horizontal bar of the T) and the second portion (vertical bar of the T) of said knitted structure.
- a knit is produced which comprises a substantially plane base sheet provided with a succession of folds that are substantially perpendicular to said base sheet.
- a warp knitting machine can comprise one or more guide bars.
- Each guide bar is supplied with a particular yarn that is stored in wound-up form on what is called a warp beam rod, said yarn being unwound from the warp beam rod at the rate by which it is used up in the movements of said guide bar when the latter performs its part in producing the knit according to the defined weave.
- the weave defines the movements of the yarns of the guide bars for forming the desired meshes in the course of production of the knit.
- the expression “weave repeat” applies to the basic pattern of these movements and corresponds to a defined number of meshes, the knit being produced by means of the weave repeat recurring as desired.
- each guide bar there is a particular yarn and a particular warp beam rod.
- the yarn is unwound from the warp beam rod at a dedicated run-in for said guide bar.
- each guide bar is supplied with a particular yarn at a dedicated run-in, independently of the yarns and the run-in rates of the other guide bars.
- the different run-in rates can be regulated by motors which can be managed by mechanical or electronic systems.
- the respective values of the respective dedicated run-in rates of the different guide bars cannot be values less than zero and are generally positive.
- the values of the dedicated run-in rates of the guide bars in general in a warp knitting machine are generally above 1,000 mm/rack, a rack corresponding to 480 meshes.
- a “positive” value of a dedicated run-in is understood as a value of greater than or equal to 1,000 mm/rack, a rack corresponding to 480 meshes.
- a value “tending towards 0” of a dedicated run-in is understood as meaning that the value of said run-in is less than or equal to 50 mm/rack, preferably less than or equal to 25 mm/rack, a rack corresponding to 480 meshes.
- the temporary decrease (temporary since only on part of the weave repeat) in the value of the variable dedicated run-in of bar B1, in such a way as to cause this value to tend towards 0, makes it possible to slow down the production of that part of the knit generated by the movement of bar B1, and a fold, said perpendicular fold, forms.
- all of the yarns threaded on the three bars continue to cooperate with each other to form said weave repeat, and no discontinuity forms between the fold thus generated and the base sheet of the knit.
- the regulation of the run-in D1 and the variation of its value can be generated by an electronic system controlling the guide bar B1.
- the prosthesis according to the invention comprising a T-shaped knitted structure obtained from such a knit, no longer has any discontinuity in its mechanical performance between the two portions of its knitted structure, namely between the horizontal bar and the vertical bar of the T. No point or line of weakness is created in the knitted structure of the prosthesis according to the invention.
- the prosthesis according to the invention thus has good strength when it is stressed in a direction perpendicular to the joining line between the two portions of its knitted structure.
- the risk of tearing at the join between the two portions of the knitted structure of the prosthesis is extremely limited.
- each of bars B2 and B3 has a dedicated run-in (D2, D3) that is constant over the whole of said weave repeat.
- D2, D3 the values of the dedicated run-in rates D2 and D3 are positive. These values can, for example, be greater than or equal to 1,000 mm/rack. For example, these values vary from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes.
- the value of D2 can be different than the value of D3.
- D2 and D3 can have the same value.
- the three bars B1, B2 and B3 are supplied with yarns according to respective positive dedicated run-in values, all of them preferably greater than or equal to 1,000 mm/rack, for example ranging from 1,000 to 2,500 mm/rack, and they form the substantially plane base sheet of the knit.
- the value of the dedicated run-in of bar 1 is decreased so as to tend towards 0 over part of the weave repeat, that is to say during a defined period of time corresponding to a defined number of meshes.
- the weave repeat comprises 138 meshes.
- the value of the run-in D1 of bar B1 is forced to tend towards 0 during 45 meshes (part of the weave repeat [(0-0) ⁇ 45]).
- the perpendicular fold of the knit therefore forms during these 45 meshes, and it is formed from the yarns of bars B2 and B3 which continue to produce their respective weave repeats, determined by their respective charts shown above, during these 45 meshes.
- the yarns of bar B1 which join the perpendicular fold to the base sheet, are an integral part of the knit, and they are thus likewise an integral part of the knitted structure obtained by cutting as described above, by joining the vertical bar of the T to the horizontal bar of the latter.
- the knitted structure of the prosthesis according to the invention is openworked. It has openings or pores at its surface and within its body, corresponding in particular to the different meshes of said knit. Such an openworked structure promotes the penetration of cells into the knitted structure and, therefore, the cell recolonization of the prosthesis after implantation.
- the knitted structure can be used as it is to form a prosthesis for reinforcing the abdominal wall, or it can form part of such a reinforcement prosthesis.
- the knitted structure can be subjected to one or more steps that are customary in the manufacture of a prosthesis, for example thermosetting, washing, cutting, thermoforming.
- the knitted structure can be partially or completely coated on some or all of its faces with a coating of biocompatible material, for example anti-adhesion material.
- the knitted structure can be combined with another textile to form a composite reinforcement prosthesis.
- the knitted structure is sufficiently flexible to be folded back on itself if necessary, for example at the time when introducing it into the abdominal cavity.
- the knitted structure of the prosthesis according to the invention can be bioabsorbable, permanent, or partially bioabsorbable.
- it can be produced by knitting biocompatible yarns, for example monofilaments and/or multifilaments, made of any bioabsorbable or non-bioabsorbable biocompatible material.
- the knitted structure is composed of monofilament yarns. With such an embodiment, it is possible in particular to obtain a good stability of the knitted structure, in particular a good retention of its T shape, in the absence of any external stress exerted on said structure.
- the monofilament yarns can have any diameter with which it is possible to obtain a knit that is suitable for the production of a prosthesis for reinforcing the abdominal wall.
- the mean diameter of the monofilament yarns can vary from 80 ⁇ m to 200 ⁇ m.
- the monofilament yarn threaded on bar B1 has a mean diameter greater than the respective mean diameters of the monofilament yarns threaded on bars B2 and B3.
- bioabsorbable is understood as the characteristic by which a material is absorbed by the biological tissues and disappears in vivo after a given period which, for example, can vary from one day to several months, depending on the chemical nature of the material.
- the knitted structure of the prosthesis according to the invention can be produced from yarns that are entirely bioabsorbable, in particular if it is intended to disappear after having performed its reinforcing function while cell colonization takes place and tissue rehabilitation takes over.
- said knitted structure is composed of bioabsorbable yarns.
- the knitted structure can comprise non-bioabsorbable yarns if the prosthesis is intended to act as a permanent reinforcement and to remain definitively within the body of the patient.
- the bioabsorbable materials suitable for the yarns of the knitted structure of the present invention can be chosen from among polylactic acid (PLA), polyglycolic acid (PGA), oxidized cellulose, polycaprolactone (PCL), polydioxanone (PDC), trimethylene carbonate (TMC), polyvinyl alcohol (PVA), polyhydroxyalkanoates (PHAs), polyamides, polyesters, copolymers thereof, and mixtures thereof.
- PLA polylactic acid
- PGA polyglycolic acid
- PCL polycaprolactone
- PDC polydioxanone
- TMC trimethylene carbonate
- PVA polyvinyl alcohol
- PHAs polyhydroxyalkanoates
- polyamides polyesters, copolymers thereof, and mixtures thereof.
- the non-bioabsorbable materials suitable for the yarns of the knitted structure of the present invention can be chosen from among polyethylene terephthalate (PET), polyamides, aramids, expanded polytetrafluoroethylene, polyurethane, polyvinyl idene di fluoride (PVDF), polybutyl esters, PEEK (polyether ether ketone), polyolefins (such as polyethylene or polypropylene), copper alloys, silver alloys, platinum, medical grades of steel such as medical-grade stainless steel, and combinations thereof.
- PET polyethylene terephthalate
- PVDF polyamides
- aramids expanded polytetrafluoroethylene
- PVDF polyurethane
- PVDF polyvinyl idene di fluoride
- PEEK polyether ether ketone
- polyolefins such as polyethylene or polypropylene
- copper alloys silver alloys
- platinum platinum
- medical grades of steel such as medical-grade stainless steel
- the face of said first portion intended to be placed opposite the abdominal cavity is covered by an anti-adhesion coating.
- anti-adhesion is understood as referring to a biocompatible material or coating that is smooth and non-porous, provides no space for cell recolonization and prevents the surrounding organs from attaching themselves to the prosthesis.
- the anti-adhesion material or coating can be chosen from bioabsorbable materials, non-bioabsorbable materials and mixtures thereof.
- the non-bioabsorbable anti-adhesion material can be chosen from polytetrafluoroethylene, polysiloxanes, polyurethanes, stainless steels, derivatives of precious metals, and mixtures thereof.
- Said anti-adhesion material or coating is preferably bioabsorbable: the bioabsorbable materials suitable for said anti-adhesion coating can be chosen from collagens, for example oxidized collagen, oxidized celluloses, polyacrylates, trimethylene carbonates, caprolactones, dioxanones, glycolic acid, lactic acid, glycolides, lactides, polysaccharides, for example chitosans, polyglucuronic acids, hyaluronic acids, dextrans, fucans, polyethylene glycol, glycerol and mixtures thereof.
- collagens for example oxidized collagen, oxidized celluloses, polyacrylates, trimethylene carbonates, caprolactones, dioxanones, glycolic acid, lactic acid, glycolides, lactides, polysaccharides, for example chitosans, polyglucuronic acids, hyaluronic acids, dextrans, fucans, polyethylene glycol, glycerol and mixtures thereof.
- the anti-adhesion coating makes it possible, at least during the initial phase of healing, to protect the knitted structure of the prosthesis at the place where this anti-adhesion coating is present; thus, the covered face is not exposed to inflammatory cells such as granulocytes, monocytes, macrophages or even the multi-nuclear giant cells that are generally activated by the surgery. Indeed, at least during the initial phase of healing, the duration of which can vary between 5 and 10 days approximately, only the anti-adhesion coating can be accessed by the various factors such as proteins, enzymes, cytokines or cells of the inflammatory line.
- the anti-adhesion coating is made of non-absorbable materials, it thus protects the knitted structure before and after implantation, throughout the period of implantation of the prosthesis.
- the surrounding fragile tissues for example the hollow viscera
- the surrounding fragile tissues are protected, in particular from the formation of undesirable and serious post-surgical fibrous adhesions.
- the anti-adhesion material comprises a bioabsorbable material
- the anti-adhesion coating is in the form of a bioabsorbable film.
- FIGS. 1A and 1B are representations of the charts of the weave repeat of bar B1 for implementing the method according to the invention
- FIG. 1C is a representation of the chart of the weave repeat for bar B2 for implementing the method according to the invention
- FIG. 1D is a representation of the chart of the weave repeat of bar B3 for implementing the method according to the invention
- FIG. 2 is a diagram showing a perspective view of a knit obtained by the method according to the invention.
- FIG. 3 is a diagram showing a perspective view of a knitted structure of a prosthesis according to the invention
- FIG. 4 is a cross-sectional view of a prosthesis according to the invention in place within an incision in an abdominal wall that is to be closed.
- a knit comprising a base sheet and a succession of substantially perpendicular folds is produced by the method according to the invention on a warp knitting machine with three guide bars B1, B2 and B3, such as those described above, where bar B1 is in position 1 on the knitting machine, bar B2 is in position 2 , and bar B3 is in position 3 .
- the threading, the run-in rates, the weaves and the charts are the following, in accordance with the standard ISO 11676:
- Bar B1 is threaded 1 full, 3 empty, its dedicated run-in D1 is variable: thus, the value of D1 is positive and constant, in other words ranging from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes, on a first part of the weave repeat, namely on the part [(0-0/0-0/1-0/1-1/1-1/1-0) ⁇ 15]. Then this value decreases and tends towards zero on the part of the weave repeat [(0-0) ⁇ 45].
- the yarn threaded on bar B1 is, for example, a monofilament yarn of polylactic acid (PLA) having a mean diameter of 150 ⁇ m.
- PLA polylactic acid
- Bar B2 is threaded 1 full, 1 empty, its dedicated run-in D2 has a positive constant value, in other words ranging from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes.
- Bar B3 is threaded 1 full, 1 empty, its dedicated run-in D3 has a positive constant value, in other words ranging from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes.
- the yarns threaded on the bars B2 and B3 are, for example, monofilament yarns of polylactic acid (PLA) having a mean diameter of 80 ⁇ m.
- PLA polylactic acid
- the present example will result in a knit, hence a knitted structure, that is entirely bioabsorbable.
- the yarns threaded on the three bars could be monofilaments of polyethylene terephthalate (PET).
- PET polyethylene terephthalate
- FIG. 1A illustrates the chart, namely the movement over 6 meshes, of the yarn of bar B1 on the first part of its weave, namely on the part [(0-0/0-0/1-0/1-1/1-1/1-0) ⁇ 15] on which the value of D1 is constant and positive.
- the movement shown in this figure for 6 meshes is repeated 15 times, over a total of 90 meshes.
- FIG. 1B illustrates the movement of the yarn of bar B1 on the second part of its weave, namely on the part [(0-0) ⁇ 45] on which the value of D1 tends towards 0. Indeed, on this first part of the weave, namely for 45 meshes, the yarn remains as it were in place, since it is not used up.
- FIG. 1C illustrates the chart, namely the movement over 6 meshes, of the yarn of bar B2 on the whole of its weave, the value D2 being constant and positive.
- the movement shown in this figure for 6 meshes is repeated 23 times, on a total of 138 meshes.
- FIG. 1D illustrates the chart, namely the movement over 6 meshes, of the yarn of bar B3 on the whole of its weave, the value D3 being constant and positive.
- the movement shown in this figure for 6 meshes is repeated 23 times, on a total of 138 meshes.
- the chart comprises 6 meshes (numbered from 1 to 6 in FIGS. 1A, 1C and 1D ).
- the yarn repeats the same chart and recommences the same movement every 6 meshes.
- run-in rates D1-D3 are appropriate to the respective movements of the guide bars.
- these values are generally in excess of 1,000 mm/rack, a rack corresponding to 480 meshes.
- the weave repeat comprises 138 meshes.
- the same chart (6 meshes) is repeated 23 times on one weave repeat.
- the three bars B1, B2 and B3 are supplied with yarns at dedicated run-in rates which all have constant and positive values, and which are preferably all greater than or equal to 1,000 mm/rack, and the three bars produce the substantially plane base sheet of the knit.
- the value of the dedicated run-in D1 of bar B1 is reduced so as to tend towards 0 across a defined number of meshes, namely 45 meshes in the present example.
- the respective dedicated run-in rates of the other two bars B2 and B3 continue to produce their respective parts of the knit of the base sheet. Since the latter cannot be generated in the direction of production of the knit on account of the value of the run-in D1 of bar B1 tending towards 0, it extends perpendicularly with respect to the direction of production of the knit and forms a fold.
- the weave repeat is recommenced from the start.
- the dedicated run-in D1 resumes its initial positive value greater than or equal to 1,000 mm/rack, and the three bars resume their respective productions of the knit in the direction of production of the knit and they again form the substantially plane base sheet, until the next variation of the value of D1 and the production of the following fold.
- a knit is thereby obtained which comprises a base sheet and a succession of substantially perpendicular folds.
- FIG. 2 such a knit 1 is shown that has been obtained according to the method described above.
- the knit 1 comprises a substantially plane base sheet 2 , and perpendicular folds 3 spaced apart from one another at uniform intervals corresponding to the weave repeat.
- This figure also shows schematically the yarns 4 of bar B1, which have not advanced in the direction of production of the knit 1 , indicated by the arrow F, during the decrease in the value of D1 across the 45 meshes of the second part of the weave repeat of bar B1 as described above.
- the yarns 4 form an integral part of the knit 1 , and they join the base sheet 2 to the fold 3 without creating any discontinuity or area of weakness.
- the knit 1 is then cut in the area of its base sheet 2 , on each side of a perpendicular fold 3 , along the cutting lines 5 indicated by dot-and-dash lines, this step being indicated schematically in FIG. 2 by the representation of a pair of scissors.
- a knitted structure 6 as shown in FIG. 3 , is thus obtained in one piece.
- This knitted structure 6 has the general shape of a T, shown upside down in this figure, and thus comprises a first portion 7 , which is substantially plane and flexible and can be placed between the abdominal wall and the abdominal cavity, and a second portion 8 , which is substantially plane and flexible and is intended to be placed between the two margins of a parietal incision, as will be seen in FIG. 4 , said second portion 8 extending substantially perpendicularly from one face of said first portion 7 .
- the knitted structure 6 forming the T-shaped skeleton of the prosthesis according to the invention is made in one piece, and there is no area of weakness created at the join 9 between the first portion 7 and the second portion 8 .
- the knitted structure of the present example is composed of monofilament yarns.
- its stability and the retention of its T shape in the absence of external stress are particularly excellent.
- the three bars B1-B3 above are all threaded with monofilament yarns of one and the same biocompatible material, namely polylactic acid (PLA), the yarns of bar B1 having a mean diameter greater than the mean diameter of the yarns of bars B2 and B3. This results in optimal continuity of the properties of strength of the two portions of the knitted structure in the area of the joining line of said two portions.
- PLA polylactic acid
- the knitted structure 6 can be used as it is as a prosthesis for reinforcing the abdominal wall.
- the knitted structure 6 can be subjected to one or more steps that are customary in the manufacture of a prosthesis, for example thermosetting, washing, cutting, thermoforming.
- the prosthesis 10 comprises a knitted structure 6 as described above which is thermoset and which is provided, on the face of the first portion 7 directed away from the second portion 8 , with a layer of anti-adhesion coating 11 , as shown in FIG. 4 .
- FIG. 4 shows an incision 100 in the abdominal wall 101 , for example created for the needs of a surgical intervention.
- the skin 103 , the abdominal wall 101 and the peritoneum 104 have been incised.
- the surgeon introduces the prosthesis 10 into the abdominal cavity 102 and positions it so as to place the first portion 7 between the abdominal wall 101 and the abdominal cavity 102 , with the anti-adhesion coating 11 opposite the abdominal cavity 102 , and the second portion 8 between the two margins of the incision 100 .
- the knitted structure 6 and the anti-adhesion coating 11 are sufficiently flexible to be able to be deformed when the prosthesis is introduced at the site of implantation.
- the surgeon can then suture the second portion 8 of the prosthesis 10 to the muscles of the abdominal wall 101 .
- the prosthesis 10 thus implanted is able to reinforce the abdominal wall and reduce the risk of occurrence of a hernia after an incision has been made in the abdominal wall for the requirements of a surgical intervention.
- the knitted structure 6 forming the skeleton of the prosthesis 10 is made in one piece, the prosthesis shows no discontinuity in its performance at the join between the first portion 7 and the second portion 8 . Therefore, the risks of the prosthesis tearing at this join under the effect of the pressures/forces applied to the prosthesis in the direction of its width are extremely limited.
Abstract
The invention relates to a method for producing a prosthesis comprising a knitted structure made in one piece, in which method a knit (1) comprising a base sheet (2) and a succession of perpendicular folds (3) is produced in a single knitting step, and said knit (1) is then cut on each side of said folds (3) in order to obtain said knitted structure.
Description
- The present invention relates to a method for producing a prosthesis for reinforcing an abdominal wall in which an incision has been made, said prosthesis being formed from a T-shaped knitted structure made in one piece.
- The abdominal wall in humans is composed of fat and muscles interconnected by fascias. It sometimes happens that a break in continuity occurs in the fascias, allowing part of the peritoneum to slip through and form a sac, or a hernia, containing either fat or part of the intestines. A hernia of this kind can occur on a parietal scar following surgery and is then called an incisional hernia. An incisional hernia shows itself in the form of a bulge at the surface of the skin, and its reduction necessitates a further surgical intervention.
- Following a surgical intervention that required an incision of the abdominal wall, for example in vascular or gynaecological surgery, it is therefore important that the closure of the incision made in the abdominal wall is optimal, so as to reduce the risks of future occurrence of an incisional hernia. With this in mind, it is desirable to be able to reinforce the abdominal wall, and in particular the muscles thereof, at the site where the suture has been made to close the incision.
- In the field of prevention or repair of hernias in general, prostheses exist which comprise, for example, a first sheet of material intended to plug the hernial defect, and a second sheet of material intended to be placed in contact with the viscera, the first and second sheets being substantially perpendicular to each other, such that a transverse cross section of the prosthesis generally forms a T shape, one sheet forming the vertical bar of the T, the other sheet forming the horizontal bar of the T.
- These sheets of material can be openworked. In the present application, “openworked material” is understood as meaning that the material has openings or pores at its surface and within its body. An openworked material promotes cell recolonization once the prosthesis has been implanted.
- The existing T-shaped prostheses are generally produced from two separate sheets, which are subsequently joined to each other to obtain said T shape. Thus, the method of producing these existing prostheses is long-winded and complicated. The two sheets of material can be joined, for example, by sewing or else by a thermal welding means. However, particularly when these sheets are made of openworked material, such joining means may create a weakness of the prosthesis, for example a point of weakness at the join between the two sheets of material. Once implanted, the prosthesis is subjected to various pressures and/or tensions, for example by the abdominal cavity or by the muscles of the abdominal wall, which pressures and/or tensions are generated by the movements and/or efforts made by the patient in his or her daily routine. This point of weakness could therefore prove dangerous for the patient in the event of tearing.
- Moreover, every solution for joining the first sheet of material to the second sheet of material in the existing prostheses, by adding a foreign material to the prosthesis or by modifying the chemical structure of the prosthesis by a thermal or mechanical process, is susceptible of creating a discontinuity in the performance of the prosthesis as a whole, and such discontinuity is undesirable.
- There is still therefore a need for a reinforcement prosthesis that would comprise a skeleton of which the transverse cross section would generally form a T, hereinafter referred to for simplicity as a “T-shaped” skeleton, structure or prosthesis, having no area of weakness at the join between the vertical bar and the horizontal bar of the T.
- There is also still a need for a method allowing simple and rapid production of such a T-shaped skeleton made of openworked material from which it would be possible to produce such a reinforcement prosthesis, having a continuous strength throughout the prosthesis, without any area of weakness at the join between the vertical bar and the horizontal bar of the T.
- The present invention aims to meet this need by making available a prosthesis for reinforcing an abdominal wall in which an incision has been made, said prosthesis comprising a knitted structure made in one piece, said knitted structure comprising a first portion, which is substantially plane and flexible and is intended to be placed between the abdominal wall and the abdominal cavity, and a second portion, which is substantially plane and flexible and is intended to be placed between the two margins of the incision, said second portion extending substantially perpendicularly from one face of said first portion.
- The present invention also relates to a method for producing such a prosthesis, said method comprising the following steps:
- a) producing a knit comprising a base sheet which is substantially plane and elongate and which is equipped in its longitudinal direction with a succession of folds substantially perpendicular to said sheet, by knitting biocompatible yarns on a warp knitting machine, said yarns being distributed on at least three guide bars B1, B2 and B3, said three bars operating according to a defined weave repeat recurring as desired along the production length of the knit, each bar being supplied with a yarn coming from a corresponding warp beam rod at a dedicated run-in appropriate to the movement of said bar in accordance with said weave repeat, at least bar B1 having a variable dedicated run-in D1, the value of said variable dedicated run-in D1 decreasing and tending towards 0 on a part of said weave repeat, the decrease in the value of said run-in D1 on said part of said weave repeat generating a said perpendicular fold,
- b) cutting from the knit obtained in step a) a knitted structure comprising a part of said base sheet equipped with a perpendicular fold, said part of the base sheet forming said first portion of the prosthesis, and said perpendicular fold forming said second portion of the prosthesis.
- The knitted structure forming the T-shaped skeleton of the prosthesis according to the invention is made in one piece, in particular in one knit, obtained in a single knitting step. In the present application, a knitted structure made in one piece is understood as meaning that said structure is produced in a single knitting step and is not formed from two or more separate pieces that are connected by a joining means, for example sewing, ultrasonic welding, etc. Thus, in the knitted structure of the prosthesis according to the invention, the yarns from which it is made present a continuity across the entire surface of the structure.
- In particular, the T-shaped skeleton of the prosthesis according to the invention is not obtained by joining two sheets of material. In the prosthesis according to the invention, the first portion, which is intended to be placed between the abdominal wall and the abdominal cavity, and the second portion, which is intended to be placed between the two margins of the incision, are one and the same knit. As a result, the join between the two portions does not require any connecting means, for example sewing, thermal welding, etc. Indeed, as will become clear from the description below, it is the same yarns that form both the base sheet of the knit, in other words the first portion of the prosthesis, and also the perpendicular folds of the knit, in other words the second portion of the prosthesis.
- In the present application, “plane and flexible portion” is understood as meaning that said portion has the general form of a plane textile and that it can be manipulated and deformed easily, for example in order to fold it back on itself at the time of introduction of the prosthesis into the body of a patient. Moreover, the knitted structure is formed from biocompatible yarns that have a rigidity necessary for maintaining the T shape of said knitted structure, that is to say for maintaining the perpendicular position of the second portion with respect to the first portion, in the absence of any stress exerted on a portion of said structure.
- The production method according to the invention makes it possible to produce a knitted structure of which the transverse cross section has the overall shape of a T, without creating discontinuity between the first portion (horizontal bar of the T) and the second portion (vertical bar of the T) of said knitted structure.
- Indeed, according to the method of the invention, a knit is produced which comprises a substantially plane base sheet provided with a succession of folds that are substantially perpendicular to said base sheet.
- A warp knitting machine can comprise one or more guide bars. Each guide bar is supplied with a particular yarn that is stored in wound-up form on what is called a warp beam rod, said yarn being unwound from the warp beam rod at the rate by which it is used up in the movements of said guide bar when the latter performs its part in producing the knit according to the defined weave. In the field of knitting, the weave defines the movements of the yarns of the guide bars for forming the desired meshes in the course of production of the knit. The expression “weave repeat” applies to the basic pattern of these movements and corresponds to a defined number of meshes, the knit being produced by means of the weave repeat recurring as desired.
- Corresponding to each guide bar, there is a particular yarn and a particular warp beam rod. For each combination of “guide bar/corresponding warp beam rod”, the yarn is unwound from the warp beam rod at a dedicated run-in for said guide bar. Thus, each guide bar is supplied with a particular yarn at a dedicated run-in, independently of the yarns and the run-in rates of the other guide bars. The different run-in rates can be regulated by motors which can be managed by mechanical or electronic systems.
- Since the production of the knit causes yarns to be used up, the respective values of the respective dedicated run-in rates of the different guide bars cannot be values less than zero and are generally positive.
- By way of example, the values of the dedicated run-in rates of the guide bars in general in a warp knitting machine are generally above 1,000 mm/rack, a rack corresponding to 480 meshes.
- In the present application, a “positive” value of a dedicated run-in is understood as a value of greater than or equal to 1,000 mm/rack, a rack corresponding to 480 meshes. In the present application, a value “tending towards 0” of a dedicated run-in is understood as meaning that the value of said run-in is less than or equal to 50 mm/rack, preferably less than or equal to 25 mm/rack, a rack corresponding to 480 meshes.
- According to the method of the invention, the temporary decrease (temporary since only on part of the weave repeat) in the value of the variable dedicated run-in of bar B1, in such a way as to cause this value to tend towards 0, makes it possible to slow down the production of that part of the knit generated by the movement of bar B1, and a fold, said perpendicular fold, forms. However, during the time of this slowing down, all of the yarns threaded on the three bars continue to cooperate with each other to form said weave repeat, and no discontinuity forms between the fold thus generated and the base sheet of the knit.
- The regulation of the run-in D1 and the variation of its value can be generated by an electronic system controlling the guide bar B1.
- Thus, the prosthesis according to the invention, comprising a T-shaped knitted structure obtained from such a knit, no longer has any discontinuity in its mechanical performance between the two portions of its knitted structure, namely between the horizontal bar and the vertical bar of the T. No point or line of weakness is created in the knitted structure of the prosthesis according to the invention.
- The prosthesis according to the invention thus has good strength when it is stressed in a direction perpendicular to the joining line between the two portions of its knitted structure. In the prosthesis according to the invention, the risk of tearing at the join between the two portions of the knitted structure of the prosthesis is extremely limited.
- In one embodiment of the method according to the invention, each of bars B2 and B3 has a dedicated run-in (D2, D3) that is constant over the whole of said weave repeat. As has been seen above, the values of the dedicated run-in rates D2 and D3 are positive. These values can, for example, be greater than or equal to 1,000 mm/rack. For example, these values vary from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes. The value of D2 can be different than the value of D3. Alternatively, D2 and D3 can have the same value.
- Thus, during a defined period of the weave repeat, in other words during a defined number of meshes, the three bars B1, B2 and B3 are supplied with yarns according to respective positive dedicated run-in values, all of them preferably greater than or equal to 1,000 mm/rack, for example ranging from 1,000 to 2,500 mm/rack, and they form the substantially plane base sheet of the knit. Sequentially, since recurring at each new resumption of the weave repeat, the value of the dedicated run-in of
bar 1 is decreased so as to tend towards 0 over part of the weave repeat, that is to say during a defined period of time corresponding to a defined number of meshes. During this defined period of time, the values of the respective dedicated run-in rates of the two other bars B2 and B3 are not decreased and they are kept constant. Thus, bars B2 and B3 continue to produce their respective parts of the knit of the base sheet. Since the latter cannot be generated in the direction of production of the knit on account of the value of the run-in D1 of bar B1 tending towards 0, it extends perpendicularly with respect to the direction of production of the knit and forms a fold. When the dedicated run-in D1 recovers its initial positive value of greater than or equal to 1,000 mm/rack, the three bars resume their respective productions of the knit in the direction of production of the knit and they again form the substantially plane base sheet. - In one embodiment of the method of the invention:
-
- the weave repeat for bar B1 is the following: bar B1 is threaded 1 full, 3 empty according to the following chart according to the standard ISO 11676:
- B1: [(0-0/0-0/1-0/1-1/1-1/1-0)×15]−(1-0)/[(0-0)×45]/0-1/1-0//
- the value of the run-in D1 tending towards 0 over the part of the weave repeat [(0-0)×45],
- the weave repeat for bar B2 is the following: bar B2 is threaded 1 full, 1 empty according to the following chart according to the standard ISO 11676:
- B2: [1-0/2-3/2-1/2-3/1-0/1-2//]×23,
- the value of the run-in D2 having a constant value over the whole of the weave repeat,
- the weave repeat for bar B3 is the following: bar B3 is threaded 1 full, 1 empty according to the following chart according to the standard ISO 11676:
- B3: [3-4/2-1/2-3/2-1/3-4/3-2//]×23,
- the value of the run-in D3 having a constant value over the whole of the weave repeat.
- Thus, in such a case, for each bar, the weave repeat comprises 138 meshes. The value of the run-in D1 of bar B1 is forced to tend towards 0 during 45 meshes (part of the weave repeat [(0-0)×45]). The perpendicular fold of the knit therefore forms during these 45 meshes, and it is formed from the yarns of bars B2 and B3 which continue to produce their respective weave repeats, determined by their respective charts shown above, during these 45 meshes.
- Since the weave repeat recurs in the direction of production of the knit as the knitting machine is fed, a knit comprising a base sheet and a succession of substantially perpendicular folds is produced. Moreover, since the same weave repeat recurs every 138 meshes along the length of production of the knit, the perpendicular folds are spaced apart from one another at regular intervals.
- The values given above for the charts, threadings and weave repeats have of course been given as examples. Other charts, threadings and weave repeats can be used to produce a knit comprising a base sheet provided with a succession of substantially perpendicular folds, if the value of the dedicated run-in D1 is forced to tend towards 0 on part of the weave repeat of bar B1.
- To produce the prosthesis according to the invention, it then suffices to cut the resulting knit on each side of a substantially perpendicular fold in order to obtain a knitted structure made in one piece and having a T-shaped transverse cross section free of any discontinuity or weakness at the join between the vertical and horizontal bars of the T. Indeed, as will become clear from the description below, the yarns of bar B1, which join the perpendicular fold to the base sheet, are an integral part of the knit, and they are thus likewise an integral part of the knitted structure obtained by cutting as described above, by joining the vertical bar of the T to the horizontal bar of the latter.
- The knitted structure of the prosthesis according to the invention is openworked. It has openings or pores at its surface and within its body, corresponding in particular to the different meshes of said knit. Such an openworked structure promotes the penetration of cells into the knitted structure and, therefore, the cell recolonization of the prosthesis after implantation.
- The knitted structure can be used as it is to form a prosthesis for reinforcing the abdominal wall, or it can form part of such a reinforcement prosthesis. In particular, the knitted structure can be subjected to one or more steps that are customary in the manufacture of a prosthesis, for example thermosetting, washing, cutting, thermoforming.
- In one embodiment, the knitted structure can be partially or completely coated on some or all of its faces with a coating of biocompatible material, for example anti-adhesion material. Alternatively or in addition, the knitted structure can be combined with another textile to form a composite reinforcement prosthesis.
- The knitted structure is sufficiently flexible to be folded back on itself if necessary, for example at the time when introducing it into the abdominal cavity.
- The knitted structure of the prosthesis according to the invention can be bioabsorbable, permanent, or partially bioabsorbable. Thus, it can be produced by knitting biocompatible yarns, for example monofilaments and/or multifilaments, made of any bioabsorbable or non-bioabsorbable biocompatible material.
- In one embodiment, the knitted structure is composed of monofilament yarns. With such an embodiment, it is possible in particular to obtain a good stability of the knitted structure, in particular a good retention of its T shape, in the absence of any external stress exerted on said structure.
- The monofilament yarns can have any diameter with which it is possible to obtain a knit that is suitable for the production of a prosthesis for reinforcing the abdominal wall. For example, the mean diameter of the monofilament yarns can vary from 80 μm to 200 μm.
- In one embodiment of the method of the invention using bars B1, B2 and B3 and the threadings and weave repeats described above, and with said three bars B1-B3 being threaded with monofilament yarns made of one and the same biocompatible material, the monofilament yarn threaded on bar B1 has a mean diameter greater than the respective mean diameters of the monofilament yarns threaded on bars B2 and B3. Such an embodiment permits optimal continuity of the properties of strength of the two portions of the knitted structure thus obtained in the area of the joining line of said two portions. Therefore, the risks of the prosthesis, obtained from such a knitted structure, tearing after implantation, and when subjected to the pressures and forces resulting from the everyday movement of the patient, are extremely limited.
- In the present application, “bioabsorbable” is understood as the characteristic by which a material is absorbed by the biological tissues and disappears in vivo after a given period which, for example, can vary from one day to several months, depending on the chemical nature of the material.
- The knitted structure of the prosthesis according to the invention can be produced from yarns that are entirely bioabsorbable, in particular if it is intended to disappear after having performed its reinforcing function while cell colonization takes place and tissue rehabilitation takes over. Thus, in one embodiment, said knitted structure is composed of bioabsorbable yarns.
- In other embodiments, the knitted structure can comprise non-bioabsorbable yarns if the prosthesis is intended to act as a permanent reinforcement and to remain definitively within the body of the patient.
- Thus, the bioabsorbable materials suitable for the yarns of the knitted structure of the present invention can be chosen from among polylactic acid (PLA), polyglycolic acid (PGA), oxidized cellulose, polycaprolactone (PCL), polydioxanone (PDC), trimethylene carbonate (TMC), polyvinyl alcohol (PVA), polyhydroxyalkanoates (PHAs), polyamides, polyesters, copolymers thereof, and mixtures thereof. The non-bioabsorbable materials suitable for the yarns of the knitted structure of the present invention can be chosen from among polyethylene terephthalate (PET), polyamides, aramids, expanded polytetrafluoroethylene, polyurethane, polyvinyl idene di fluoride (PVDF), polybutyl esters, PEEK (polyether ether ketone), polyolefins (such as polyethylene or polypropylene), copper alloys, silver alloys, platinum, medical grades of steel such as medical-grade stainless steel, and combinations thereof.
- In one embodiment, the face of said first portion intended to be placed opposite the abdominal cavity is covered by an anti-adhesion coating.
- In the present application, “anti-adhesion” is understood as referring to a biocompatible material or coating that is smooth and non-porous, provides no space for cell recolonization and prevents the surrounding organs from attaching themselves to the prosthesis.
- The anti-adhesion material or coating can be chosen from bioabsorbable materials, non-bioabsorbable materials and mixtures thereof.
- The non-bioabsorbable anti-adhesion material can be chosen from polytetrafluoroethylene, polysiloxanes, polyurethanes, stainless steels, derivatives of precious metals, and mixtures thereof.
- Said anti-adhesion material or coating is preferably bioabsorbable: the bioabsorbable materials suitable for said anti-adhesion coating can be chosen from collagens, for example oxidized collagen, oxidized celluloses, polyacrylates, trimethylene carbonates, caprolactones, dioxanones, glycolic acid, lactic acid, glycolides, lactides, polysaccharides, for example chitosans, polyglucuronic acids, hyaluronic acids, dextrans, fucans, polyethylene glycol, glycerol and mixtures thereof.
- Upon implantation of the prosthesis according to the invention, the anti-adhesion coating makes it possible, at least during the initial phase of healing, to protect the knitted structure of the prosthesis at the place where this anti-adhesion coating is present; thus, the covered face is not exposed to inflammatory cells such as granulocytes, monocytes, macrophages or even the multi-nuclear giant cells that are generally activated by the surgery. Indeed, at least during the initial phase of healing, the duration of which can vary between 5 and 10 days approximately, only the anti-adhesion coating can be accessed by the various factors such as proteins, enzymes, cytokines or cells of the inflammatory line.
- In the case when the anti-adhesion coating is made of non-absorbable materials, it thus protects the knitted structure before and after implantation, throughout the period of implantation of the prosthesis.
- Moreover, by virtue of the anti-adhesion coating, the surrounding fragile tissues, for example the hollow viscera, are protected, in particular from the formation of undesirable and serious post-surgical fibrous adhesions.
- In the case when the anti-adhesion material comprises a bioabsorbable material, it is preferable to choose a bioabsorbable material that is absorbed only after a few days, so as to ensure that the anti-adhesion coating can perform its function of protecting the surrounding organs during the days after the operation and until the cell recolonization of the prosthesis in turn protects these organs.
- In one embodiment, the anti-adhesion coating is in the form of a bioabsorbable film.
- Examples of methods by which the knit is covered by an anti-adhesion coating are given in the applications WO9906079 and WO9906080.
- The advantages of the present invention will become clearer from the following description and example and from the attached drawings, in which:
-
FIGS. 1A and 1B are representations of the charts of the weave repeat of bar B1 for implementing the method according to the invention, -
FIG. 1C is a representation of the chart of the weave repeat for bar B2 for implementing the method according to the invention, -
FIG. 1D is a representation of the chart of the weave repeat of bar B3 for implementing the method according to the invention, -
FIG. 2 is a diagram showing a perspective view of a knit obtained by the method according to the invention, -
FIG. 3 is a diagram showing a perspective view of a knitted structure of a prosthesis according to the invention, -
FIG. 4 is a cross-sectional view of a prosthesis according to the invention in place within an incision in an abdominal wall that is to be closed. - A knit comprising a base sheet and a succession of substantially perpendicular folds is produced by the method according to the invention on a warp knitting machine with three guide bars B1, B2 and B3, such as those described above, where bar B1 is in
position 1 on the knitting machine, bar B2 is inposition 2, and bar B3 is inposition 3. The threading, the run-in rates, the weaves and the charts are the following, in accordance with the standard ISO 11676: -
- B1: [(0-0/0-0/1-0/1-1/1-1/1-0)×15]−(1-0)/[(0-0)×45]/0-1/1-0//
- Bar B1 is threaded 1 full, 3 empty, its dedicated run-in D1 is variable: thus, the value of D1 is positive and constant, in other words ranging from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes, on a first part of the weave repeat, namely on the part [(0-0/0-0/1-0/1-1/1-1/1-0)×15]. Then this value decreases and tends towards zero on the part of the weave repeat [(0-0)×45].
- The yarn threaded on bar B1 is, for example, a monofilament yarn of polylactic acid (PLA) having a mean diameter of 150 μm.
-
- B2: [1-0/2-3/2-1/2-3/1-0/1-2//]×23
- Bar B2 is threaded 1 full, 1 empty, its dedicated run-in D2 has a positive constant value, in other words ranging from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes.
-
- B3: [3-4/2-1/2-3/2-1/3-4/3-2//]×23
- Bar B3 is threaded 1 full, 1 empty, its dedicated run-in D3 has a positive constant value, in other words ranging from 1,000 to 2,500 mm/rack, a rack corresponding to 480 meshes.
- The yarns threaded on the bars B2 and B3 are, for example, monofilament yarns of polylactic acid (PLA) having a mean diameter of 80 μm.
- Thus, the present example will result in a knit, hence a knitted structure, that is entirely bioabsorbable.
- Alternatively, if the aim is to produce a permanent knit, that is to say a non-bioabsorbable knit, the yarns threaded on the three bars could be monofilaments of polyethylene terephthalate (PET).
-
FIG. 1A illustrates the chart, namely the movement over 6 meshes, of the yarn of bar B1 on the first part of its weave, namely on the part [(0-0/0-0/1-0/1-1/1-1/1-0)×15] on which the value of D1 is constant and positive. The movement shown in this figure for 6 meshes is repeated 15 times, over a total of 90 meshes. -
FIG. 1B illustrates the movement of the yarn of bar B1 on the second part of its weave, namely on the part [(0-0)×45] on which the value of D1 tends towards 0. Indeed, on this first part of the weave, namely for 45 meshes, the yarn remains as it were in place, since it is not used up. -
FIG. 1C illustrates the chart, namely the movement over 6 meshes, of the yarn of bar B2 on the whole of its weave, the value D2 being constant and positive. The movement shown in this figure for 6 meshes is repeated 23 times, on a total of 138 meshes. -
FIG. 1D illustrates the chart, namely the movement over 6 meshes, of the yarn of bar B3 on the whole of its weave, the value D3 being constant and positive. The movement shown in this figure for 6 meshes is repeated 23 times, on a total of 138 meshes. - As will be clear from the above weave repeats, when the values of the three run-in rates D1, D2 and D3 are positive and constant, the chart comprises 6 meshes (numbered from 1 to 6 in
FIGS. 1A, 1C and 1D ). In other words, for each bar, the yarn repeats the same chart and recommences the same movement every 6 meshes. - When they are constant and positive, the values of run-in rates D1-D3 are appropriate to the respective movements of the guide bars. By way of example, these values are generally in excess of 1,000 mm/rack, a rack corresponding to 480 meshes.
- Moreover, the weave repeat comprises 138 meshes. Thus, for bars B2 and B3, the same chart (6 meshes) is repeated 23 times on one weave repeat.
- For bar B1, the same chart (6 meshes) is repeated 15 times, in other words on 90 meshes, with the value D1 of the dedicated speed constant and positive.
- Then, after a transition mesh, the chart (0-0) is repeated 45 times, in other words on 45 meshes, with the value D1 tending towards 0. This part of the weave repeat is illustrated in
FIG. 1B . - Finally, the weave repeat for bar B1 ends with two transition meshes.
- Thus, during a defined period of the weave repeat, in other words during a defined number of meshes, namely on the first 90 meshes of the weave repeat in the present example, the three bars B1, B2 and B3 are supplied with yarns at dedicated run-in rates which all have constant and positive values, and which are preferably all greater than or equal to 1,000 mm/rack, and the three bars produce the substantially plane base sheet of the knit.
- Then, after a transition mesh, the value of the dedicated run-in D1 of bar B1 is reduced so as to tend towards 0 across a defined number of meshes, namely 45 meshes in the present example. During these 45 meshes, the respective dedicated run-in rates of the other two bars B2 and B3 continue to produce their respective parts of the knit of the base sheet. Since the latter cannot be generated in the direction of production of the knit on account of the value of the run-in D1 of bar B1 tending towards 0, it extends perpendicularly with respect to the direction of production of the knit and forms a fold.
- Once the 45 meshes have been produced, and after two transition meshes, the weave repeat is recommenced from the start. Thus, the dedicated run-in D1 resumes its initial positive value greater than or equal to 1,000 mm/rack, and the three bars resume their respective productions of the knit in the direction of production of the knit and they again form the substantially plane base sheet, until the next variation of the value of D1 and the production of the following fold.
- A knit is thereby obtained which comprises a base sheet and a succession of substantially perpendicular folds. In
FIG. 2 , such aknit 1 is shown that has been obtained according to the method described above. Theknit 1 comprises a substantiallyplane base sheet 2, andperpendicular folds 3 spaced apart from one another at uniform intervals corresponding to the weave repeat. This figure also shows schematically theyarns 4 of bar B1, which have not advanced in the direction of production of theknit 1, indicated by the arrow F, during the decrease in the value of D1 across the 45 meshes of the second part of the weave repeat of bar B1 as described above. As is clear from this figure, theyarns 4 form an integral part of theknit 1, and they join thebase sheet 2 to thefold 3 without creating any discontinuity or area of weakness. - To produce a prosthesis according to the invention from the
knit 1 obtained above, theknit 1 is then cut in the area of itsbase sheet 2, on each side of aperpendicular fold 3, along thecutting lines 5 indicated by dot-and-dash lines, this step being indicated schematically inFIG. 2 by the representation of a pair of scissors. - A
knitted structure 6, as shown inFIG. 3 , is thus obtained in one piece. Thisknitted structure 6 has the general shape of a T, shown upside down in this figure, and thus comprises afirst portion 7, which is substantially plane and flexible and can be placed between the abdominal wall and the abdominal cavity, and asecond portion 8, which is substantially plane and flexible and is intended to be placed between the two margins of a parietal incision, as will be seen inFIG. 4 , saidsecond portion 8 extending substantially perpendicularly from one face of saidfirst portion 7. - Thus, the
knitted structure 6 forming the T-shaped skeleton of the prosthesis according to the invention is made in one piece, and there is no area of weakness created at thejoin 9 between thefirst portion 7 and thesecond portion 8. - Moreover, the knitted structure of the present example is composed of monofilament yarns. Thus, its stability and the retention of its T shape in the absence of external stress are particularly excellent. Moreover, the three bars B1-B3 above are all threaded with monofilament yarns of one and the same biocompatible material, namely polylactic acid (PLA), the yarns of bar B1 having a mean diameter greater than the mean diameter of the yarns of bars B2 and B3. This results in optimal continuity of the properties of strength of the two portions of the knitted structure in the area of the joining line of said two portions.
- Therefore, when the
knitted structure 6 is stressed mechanically in the direction of production of the knit (seeFIG. 2 ), there is no risk of its mechanical performance dropping at the join between thefirst portion 7 and thesecond portion 8. - The
knitted structure 6 can be used as it is as a prosthesis for reinforcing the abdominal wall. - The
knitted structure 6 can be subjected to one or more steps that are customary in the manufacture of a prosthesis, for example thermosetting, washing, cutting, thermoforming. - In one embodiment, and with reference to
FIG. 4 , theprosthesis 10 according to the invention comprises aknitted structure 6 as described above which is thermoset and which is provided, on the face of thefirst portion 7 directed away from thesecond portion 8, with a layer ofanti-adhesion coating 11, as shown inFIG. 4 . -
FIG. 4 shows anincision 100 in theabdominal wall 101, for example created for the needs of a surgical intervention. Theskin 103, theabdominal wall 101 and theperitoneum 104 have been incised. Once the surgical intervention has been completed, at the time of closure of thisincision 100, the surgeon introduces theprosthesis 10 into theabdominal cavity 102 and positions it so as to place thefirst portion 7 between theabdominal wall 101 and theabdominal cavity 102, with theanti-adhesion coating 11 opposite theabdominal cavity 102, and thesecond portion 8 between the two margins of theincision 100. In theprosthesis 10, theknitted structure 6 and theanti-adhesion coating 11 are sufficiently flexible to be able to be deformed when the prosthesis is introduced at the site of implantation. - The surgeon can then suture the
second portion 8 of theprosthesis 10 to the muscles of theabdominal wall 101. - The
prosthesis 10 thus implanted is able to reinforce the abdominal wall and reduce the risk of occurrence of a hernia after an incision has been made in the abdominal wall for the requirements of a surgical intervention. In particular, since theknitted structure 6 forming the skeleton of theprosthesis 10 is made in one piece, the prosthesis shows no discontinuity in its performance at the join between thefirst portion 7 and thesecond portion 8. Therefore, the risks of the prosthesis tearing at this join under the effect of the pressures/forces applied to the prosthesis in the direction of its width are extremely limited.
Claims (23)
1-5. (canceled)
6. An implantable prosthesis for reinforcing an abdominal wall comprising a one-piece generally T-shaped knit structure, the knit structure comprising a base portion, which is substantially plane and flexible and at least one fold portion which is flexible and extending substantially perpendicular from a first face of said base portion, wherein the generally T-shape is without a discontinuity between the base portion and the at least one fold portion of the knit structure.
7. The implantable prosthesis of claim 6 , wherein the base portion and the fold portion of the generally T-shaped knit structure comprise at least a first and second biocompatible yarn.
8. The implantable prosthesis of claim 7 , wherein at least one of the first and second biocompatible yarns comprise a bioabsorbable material selected from the group consisting of polylactic acid (PLA), polyglycolic acid (PGA), oxidized cellulose, polycaprolactone (PCL), polydioxanone (PDO), trimethylene carbonate (TMC), polyvinyl alcohol (PVA), polyhydroxyalkanoates (PHAs), polyamides, polyesters, copolymers thereof, and mixtures thereof.
9. The implantable prosthesis of claim 7 , wherein at least one of the first and second biocompatible yarns comprise a non-bioabsorbable material selected from the group consisting of polyethylene terephthalate (PET), polyamides, aramids, expanded polytetrafluoroethylene, polyurethane, polyvinylidene difluoride (PVDF), polybutyl esters, PEEK (polyether ether ketone), polyethylene, polypropylene, and combinations thereof.
10. The implantable prosthesis of claim 7 , wherein the base portion further comprises at least a third biocompatible yarn which connects a first part of the base portion to a second part of the base portion across the fold portion.
11. The implantable prosthesis of claim 10 , wherein the third biocompatible yarn comprises a bioabsorbable material selected from the group consisting of polylactic acid (PLA), polyglycolic acid (PGA), oxidized cellulose, polycaprolactone (PCL), polydioxanone (PDO), trimethylene carbonate (TMC), polyvinyl alcohol (PVA), polyhydroxyalkanoates (PHAs), polyamides, polyesters, copolymers thereof, and mixtures thereof.
12. The implantable prosthesis of claim 10 , wherein the third biocompatible yarn comprises a non-bioabsorbable material selected from the group consisting of polyethylene terephthalate (PET), polyamides, aramids, expanded polytetrafluoroethylene, polyurethane, polyvinylidene difluoride (PVDF), polybutyl esters, PEEK (polyether ether ketone), polyethylene, polypropylene, and combinations thereof.
13. The implantable prosthesis of claim 6 , wherein the knit structure comprises a plurality of folds.
14. The implantable prosthesis of claim 13 , wherein the plurality of folds are spaced apart at uniform intervals across the knit structure.
15. The implantable prosthesis of claim 6 , wherein the knit structure is sufficiently flexible to be folded back upon itself.
16. The implantable prosthesis of claim 10 , wherein at least one of the first, second, and third biocompatible yarns is a monofilament.
17. The implantable prosthesis of claim 10 , wherein at least one of the first, second, and third biocompatible yarns is a multifilament.
18. The implantable prosthesis of claim 10 , wherein the first, second, and third biocompatible yarns are each a monofilament.
19. The implantable prosthesis of claim 18 , wherein the monofilament of the third biocompatible yarn has a mean diameter greater than a mean diameter each of the monofilaments of first and second biocompatible yarns.
20. The implantable prosthesis of claim 19 , wherein the mean diameter of the monofilament of the third biocompatible yarn is 150 μm.
21. The implantable prosthesis of claim 19 , wherein the mean diameter of each of the monofilaments of the first and second biocompatible yarns is 80 μm.
22. The implantable prosthesis of claim 18 , wherein the first, second, and third biocompatible yarns comprise polylactic acid (PLA).
23. The implantable prosthesis of claim 18 , wherein the first, second, and third biocompatible yarns comprise polyethylene terephthalate (PET).
22. The implantable prosthesis of claim 6 , wherein the knit structure is thermoset.
23. The implantable prosthesis of claim 6 , further comprising an anti-adhesion coating on a second face of the base portion opposite the first face of the base portion.
24. The implantable prosthesis of claim 23 , wherein the anti-adhesion coating is a bioabsorbable film.
25. The implantable prosthesis of claim 24 , wherein the bioabsorbable film comprises collagen.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US15/357,436 US20170065392A1 (en) | 2012-09-25 | 2016-11-21 | Method for producing a prosthesis for reinforcing the abdominal wall |
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FR1258973A FR2995778B1 (en) | 2012-09-25 | 2012-09-25 | ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME |
PCT/EP2013/069953 WO2014048981A1 (en) | 2012-09-25 | 2013-09-25 | Method for producing a prosthesis for reinforcing the abdominal wall |
US201514421222A | 2015-02-12 | 2015-02-12 | |
US15/357,436 US20170065392A1 (en) | 2012-09-25 | 2016-11-21 | Method for producing a prosthesis for reinforcing the abdominal wall |
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US14/421,222 Continuation US9499927B2 (en) | 2012-09-25 | 2013-09-25 | Method for producing a prosthesis for reinforcing the abdominal wall |
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US15/357,436 Abandoned US20170065392A1 (en) | 2012-09-25 | 2016-11-21 | Method for producing a prosthesis for reinforcing the abdominal wall |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9308070B2 (en) * | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
FR2995778B1 (en) * | 2012-09-25 | 2015-06-26 | Sofradim Production | ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME |
US9895212B2 (en) | 2014-10-31 | 2018-02-20 | Prevent Patch LLC | Devices and methods for preventing incisional hernias |
US9622844B2 (en) | 2014-10-31 | 2017-04-18 | Prevent Patch, LLC | Devices and methods for preventing incisional hernias |
WO2016160148A1 (en) | 2015-03-31 | 2016-10-06 | Prevent Patch, LLC | Devices and methods for preventing incisional hernias |
US20170079348A1 (en) * | 2015-09-17 | 2017-03-23 | Tony CHAHINE | Conductive knit patch |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5326150A (en) * | 1988-09-22 | 1994-07-05 | General Motors Corporation | Upholstery fabric |
US6151926A (en) * | 1998-06-30 | 2000-11-28 | Lear Corporation | Vehicle seat cover |
US6397638B1 (en) * | 1998-10-09 | 2002-06-04 | Stefan Achter | Method for integrating fasteners into a knitted seat cover and seat cover with fasteners |
US9499927B2 (en) * | 2012-09-25 | 2016-11-22 | Sofradim Production | Method for producing a prosthesis for reinforcing the abdominal wall |
Family Cites Families (350)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3118294A (en) | 1964-01-21 | Method for manufacturing knitted nets and products | ||
US3124136A (en) | 1964-03-10 | Method of repairing body tissue | ||
US1187158A (en) | 1915-02-18 | 1916-06-13 | Simon Friedberger | Twisted net fabric. |
US3364200A (en) | 1960-03-28 | 1968-01-16 | Johnson & Johnson | Oxidized cellulose product and method for preparing the same |
US3320649A (en) | 1962-10-23 | 1967-05-23 | Naimer Jack | Methods of making separable fastening fabrics |
US3276448A (en) | 1962-12-14 | 1966-10-04 | Ethicon Inc | Collagen coated fabric prosthesis |
US3272204A (en) | 1965-09-22 | 1966-09-13 | Ethicon Inc | Absorbable collagen prosthetic implant with non-absorbable reinforcing strands |
US3570482A (en) | 1968-12-09 | 1971-03-16 | Fujiboseki Kk | Elastic surgical bandage |
GB1454257A (en) * | 1972-07-26 | 1976-11-03 | Hamel Son Ltd E B | Curtain heading tape |
IT993386B (en) | 1973-09-24 | 1975-09-30 | Nannini G E C Sas | PROCEDURE FOR MAKING A LACE IN A RASCHEL TYPE LOOM AND LACE OBTAINED |
DE2461370A1 (en) | 1974-01-02 | 1975-07-03 | Sauvage Lester R | POROESE VASCULAR PROSTHESIS |
US4006747A (en) | 1975-04-23 | 1977-02-08 | Ethicon, Inc. | Surgical method |
US4060081A (en) | 1975-07-15 | 1977-11-29 | Massachusetts Institute Of Technology | Multilayer membrane useful as synthetic skin |
US4193137A (en) | 1977-05-06 | 1980-03-18 | Meadox Medicals, Inc. | Warp-knitted double-velour prosthesis |
US4294241A (en) | 1977-06-09 | 1981-10-13 | Teruo Miyata | Collagen skin dressing |
US4173131A (en) | 1977-08-30 | 1979-11-06 | The Kendall Co. | Porous elastic bandage |
US4307717A (en) | 1977-11-07 | 1981-12-29 | Lectec Corporation | Sterile improved bandage containing a medicament |
US4248064A (en) | 1979-02-14 | 1981-02-03 | Stedman Corporation | Lock-stitch knitted elastic fabric |
US4307496A (en) | 1979-02-19 | 1981-12-29 | Takeda Lace Co., Ltd. | Warp-knitted lace strip, material fabric, and manufacturing method thereof |
BR8000993A (en) | 1979-02-19 | 1980-10-29 | Takeda Lace | TOTALLY URIDID STRIP AND TISSUE AND PROCESS FOR ITS MANUFACTURING |
JPS6027281B2 (en) | 1979-05-09 | 1985-06-28 | ワイケイケイ株式会社 | Method for manufacturing velvet fastener tape |
US4476697A (en) | 1980-04-21 | 1984-10-16 | Karl Otto Braun Kg | Wound dressing |
DE3042860A1 (en) | 1980-11-13 | 1982-06-09 | Heyl & Co Chemisch-Pharmazeutische Fabrik, 1000 Berlin | COLLAGEN PREPARATIONS, METHODS FOR THEIR PRODUCTION AND THEIR USE IN HUMAN AND VETERINE MEDICINE |
US4591501A (en) | 1981-04-13 | 1986-05-27 | Seton Company | Cosmetic and pharmaceutical sheet material containing polypeptides |
FR2516927B1 (en) | 1981-11-26 | 1986-05-23 | Merieux Fond | PROCESS FOR THE INDUSTRIAL PREPARATION OF COLLAGENIC MATERIALS FROM HUMAN PLACENTARY TISSUES, HUMAN COLLAGENIC MATERIALS OBTAINED, THEIR APPLICATION AS BIOMATERIALS |
US4925294A (en) | 1986-12-17 | 1990-05-15 | Geshwind David M | Method to convert two dimensional motion pictures for three-dimensional systems |
JPS6014861A (en) | 1983-07-05 | 1985-01-25 | 株式会社日本メデイカル・サプライ | Adhesion preventing material |
US4500676A (en) | 1983-12-15 | 1985-02-19 | Biomatrix, Inc. | Hyaluronate modified polymeric articles |
US4487865A (en) | 1983-12-15 | 1984-12-11 | Biomatrix, Inc. | Polymeric articles modified with hyaluronate |
FR2559780B1 (en) | 1984-02-21 | 1990-05-04 | Tech Cuir Centre | IMPLANTABLE BIOCOMPATIBLE COLLAGEN-BASED SYSTEMS FOR CELL STORAGE AND / OR CULTURE AND / OR CONTROLLED RELEASE OF ACTIVE INGREDIENTS |
CA1295796C (en) | 1984-03-27 | 1992-02-18 | Conrad Whyne | Biodegradable matrix and methods for producing same |
US4837285A (en) | 1984-03-27 | 1989-06-06 | Medimatrix | Collagen matrix beads for soft tissue repair |
FR2577807B1 (en) | 1985-02-22 | 1993-12-03 | Ethnor | ABSORBABLE COMPOSITE SURGICAL MATERIAL, PREPARATION METHOD, RESORBABLE PROSTHESIS MADE FROM SUCH MATERIAL AND USE OF SUCH A PROSTHESIS |
US4631932A (en) | 1985-05-15 | 1986-12-30 | S.R.C. Textiles, Inc. | Knitted waistband curl-preventing strip |
US5720981A (en) | 1985-08-14 | 1998-02-24 | Sloan-Kettering Institute For Cancer Research | Epidermal cell extracts and method to enhance wound healing and regenerate epidermis |
US5002551A (en) | 1985-08-22 | 1991-03-26 | Johnson & Johnson Medical, Inc. | Method and material for prevention of surgical adhesions |
JPH0235207Y2 (en) | 1985-10-23 | 1990-09-25 | ||
DE3672982D1 (en) | 1985-12-05 | 1990-08-30 | Sakae Lace Kk | CHAIN-KNITTED LACE. |
US4792336A (en) | 1986-03-03 | 1988-12-20 | American Cyanamid Company | Flat braided ligament or tendon implant device having texturized yarns |
US4769038A (en) | 1986-03-18 | 1988-09-06 | C. R. Bard, Inc. | Prostheses and techniques and repair of inguinal and femoral hernias |
GB8611129D0 (en) | 1986-05-07 | 1986-06-11 | Annis D | Prosthetic materials |
DE3619197A1 (en) | 1986-06-07 | 1987-12-10 | Ethicon Gmbh | UPHOLSTERY IMPLANT |
FR2601371B1 (en) | 1986-07-11 | 1989-05-12 | Merieux Inst | PROCESS FOR TREATING COLLAGEN WITH A VIEW TO, IN PARTICULAR, FACILITATING CROSS-LINKING AND COLLAGEN OBTAINED BY APPLICATION OF SAID PROCESS |
US4854316A (en) | 1986-10-03 | 1989-08-08 | Davis Emsley A | Apparatus and method for repairing and preventing para-stomal hernias |
US4759354A (en) | 1986-11-26 | 1988-07-26 | The Kendall Company | Wound dressing |
IT1202456B (en) | 1987-01-30 | 1989-02-09 | Ausonia Spa | TEXTILE MANUFACTURE FOR CONTACT CLOSURE AND METHOD AND EQUIPMENT FOR ITS PRODUCTION |
US4813942A (en) | 1987-03-17 | 1989-03-21 | Bioderm, Inc. | Three step wound treatment method and dressing therefor |
US4937270A (en) | 1987-09-18 | 1990-06-26 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
US5015584A (en) | 1987-10-14 | 1991-05-14 | Board Of Regents, The University Of Texas System | Epidermal graft system |
US4888964A (en) * | 1988-02-22 | 1989-12-26 | Svein Klinge | Pleated knit fabric |
EP0403650B1 (en) | 1988-03-09 | 1994-05-25 | Terumo Kabushiki Kaisha | Medical material permitting cells to enter thereinto and artificial skin |
US5350583A (en) | 1988-03-09 | 1994-09-27 | Terumo Kabushiki Kaisha | Cell-penetrable medical material and artificial skin |
US5201745A (en) | 1988-03-15 | 1993-04-13 | Imedex | Visceral surgery patch |
FR2628634B1 (en) | 1988-03-15 | 1990-07-13 | Imedex | VISCERAL SURGERY PATCH |
US4950483A (en) | 1988-06-30 | 1990-08-21 | Collagen Corporation | Collagen wound healing matrices and process for their production |
US4948540A (en) | 1988-08-01 | 1990-08-14 | Semex Medical, Inc. | Method of preparing collagen dressing sheet material |
US5162430A (en) | 1988-11-21 | 1992-11-10 | Collagen Corporation | Collagen-polymer conjugates |
US5800541A (en) | 1988-11-21 | 1998-09-01 | Collagen Corporation | Collagen-synthetic polymer matrices prepared using a multiple step reaction |
US5306500A (en) | 1988-11-21 | 1994-04-26 | Collagen Corporation | Method of augmenting tissue with collagen-polymer conjugates |
US5614587A (en) | 1988-11-21 | 1997-03-25 | Collagen Corporation | Collagen-based bioadhesive compositions |
US5304595A (en) | 1988-11-21 | 1994-04-19 | Collagen Corporation | Collagen-polymer conjugates |
ZA899326B (en) | 1988-12-07 | 1991-08-28 | Johnson & Johnson Patient Care | Low molecular weight heparin,heparinoid and hexuronyl hexosaminoglycan sulfate containing adhesion prevention barrier and process |
US5171273A (en) | 1989-01-13 | 1992-12-15 | University Of Medicine And Dentistry Of New Jersey | Synthetic collagen orthopaedic structures such as grafts, tendons and other structures |
FR2641692A1 (en) | 1989-01-17 | 1990-07-20 | Nippon Zeon Co | Plug for closing an opening for a medical application, and device for the closure plug making use thereof |
FR2646343B1 (en) | 1989-04-27 | 1991-12-20 | Gazielly Dominique | DEVICE FOR REINFORCING AND SUPPORTING THE HAIR OF THE ROTATORS OF AN INDIVIDUAL SHOULDER JOINT |
US5441508A (en) | 1989-04-27 | 1995-08-15 | Gazielly; Dominique | Reinforcement and supporting device for the rotator cuff of a shoulder joint of a person |
JPH0332677A (en) | 1989-06-30 | 1991-02-13 | Yoshihiko Shimizu | Vein closing material for imparting phlogistic and clotting property |
US5196185A (en) | 1989-09-11 | 1993-03-23 | Micro-Collagen Pharmaceutics, Ltd. | Collagen-based wound dressing and method for applying same |
IL95429A (en) | 1989-09-15 | 1997-09-30 | Organogenesis | Living tissue equivalents comprising hydrated collagen lattice and a collagen gel and their production |
US5201764A (en) | 1990-02-28 | 1993-04-13 | Autogenesis Technologies, Inc. | Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom |
US5256418A (en) | 1990-04-06 | 1993-10-26 | Organogenesis, Inc. | Collagen constructs |
HUT63319A (en) | 1990-04-24 | 1993-08-30 | Mark Eisenberg | Method for producing composition equivalent with living skin |
US5141515A (en) | 1990-10-11 | 1992-08-25 | Eberbach Mark A | Apparatus and methods for repairing hernias |
US6559119B1 (en) | 1990-11-27 | 2003-05-06 | Loyola University Of Chicago | Method of preparing a tissue sealant-treated biomedical material |
US6197325B1 (en) | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
US5206028A (en) | 1991-02-11 | 1993-04-27 | Li Shu Tung | Dense collagen membrane matrices for medical uses |
CA2060223C (en) | 1991-02-12 | 1999-07-20 | Clarence C. Lee | Injectable medical lubricating fluid composition and method of use |
US5690675A (en) | 1991-02-13 | 1997-11-25 | Fusion Medical Technologies, Inc. | Methods for sealing of staples and other fasteners in tissue |
US5749895A (en) | 1991-02-13 | 1998-05-12 | Fusion Medical Technologies, Inc. | Method for bonding or fusion of biological tissue and material |
ATE186198T1 (en) | 1991-03-06 | 1999-11-15 | Aircast Inc | INJECTION MOLDED ORTHOPEDIC DEVICE AND METHOD |
US5254133A (en) | 1991-04-24 | 1993-10-19 | Seid Arnold S | Surgical implantation device and related method of use |
EP0585368B1 (en) | 1991-04-25 | 1997-08-06 | Brown University Research Foundation | Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products |
US5785983A (en) | 1991-05-23 | 1998-07-28 | Euroresearch Srl | Non-porous collagen sheet for therapeutic use, and the method and apparatus for preparing it |
US5605938A (en) | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
FR2679778B1 (en) | 1991-08-02 | 1995-07-07 | Coletica | USE OF CROLAGEN CROSSLINKED BY A CROSSLINKING AGENT FOR THE MANUFACTURE OF A SLOW RESORPTIVE, BIOCOMPATIBLE, SUTURABLE MEMBRANE, AS WELL AS SUCH A MEMBRANE. |
CA2082090C (en) | 1991-11-05 | 2004-04-27 | Jack Fagan | Improved occluder for repair of cardiac and vascular defects |
ES2069968T3 (en) | 1991-11-25 | 1995-05-16 | Cook Inc | APPARATUS FOR TISSUE DEFECTS REPAIR. |
DK168419B1 (en) | 1991-11-25 | 1994-03-28 | Cook Inc A Cook Group Company | Abdominal wall support device and apparatus for insertion thereof |
US5439467A (en) | 1991-12-03 | 1995-08-08 | Vesica Medical, Inc. | Suture passer |
US5147374A (en) | 1991-12-05 | 1992-09-15 | Alfredo Fernandez | Prosthetic mesh patch for hernia repair |
US5176692A (en) | 1991-12-09 | 1993-01-05 | Wilk Peter J | Method and surgical instrument for repairing hernia |
IT1254170B (en) | 1991-12-18 | 1995-09-11 | Mini Ricerca Scient Tecnolog | COMPOSITE MEMBRANES FOR GUIDED REGENERATION OF FABRICS |
US5376376A (en) | 1992-01-13 | 1994-12-27 | Li; Shu-Tung | Resorbable vascular wound dressings |
USRE36370E (en) | 1992-01-13 | 1999-11-02 | Li; Shu-Tung | Resorbable vascular wound dressings |
DE69324239T2 (en) | 1992-01-21 | 1999-11-04 | Univ Minnesota | SEPTUAL DAMAGE CLOSURE DEVICE |
FR2686612B1 (en) | 1992-01-24 | 1994-04-08 | Fournier Sca Laboratoires | PROCESS FOR THE PREPARATION OF COLLAGEN FIBERS. |
DE69307299T2 (en) | 1992-02-14 | 1997-04-30 | Univ Texas | MULTI-PHASE, BIODEGRADABLE IMPLANT / CARRIER AND METHOD FOR THE PRODUCTION THEREOF |
US5480644A (en) | 1992-02-28 | 1996-01-02 | Jsf Consultants Ltd. | Use of injectable biomaterials for the repair and augmentation of the anal sphincters |
FR2688222B1 (en) | 1992-03-03 | 1995-05-19 | Univ Picardie | POLYMERIC COMPOUNDS OF GLUCURONIC ACID, PROCESS FOR THE PREPARATION THEREOF, AND USE IN PARTICULAR AS GELIFYING, THICKENING, MOISTURIZING, STABILIZING, CHELATING OR FLOCCULATING MEDIA. |
WO1993017635A1 (en) | 1992-03-04 | 1993-09-16 | C.R. Bard, Inc. | Composite prosthesis and method for limiting the incidence of postoperative adhesions |
US5217493A (en) | 1992-03-11 | 1993-06-08 | Board Of Regents, The University Of Texas System | Antibacterial coated medical implants |
GB9206504D0 (en) | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges as wound implants |
GB9206509D0 (en) | 1992-03-25 | 1992-05-06 | Jevco Ltd | Heteromorphic sponges containing active agents |
IL105529A0 (en) | 1992-05-01 | 1993-08-18 | Amgen Inc | Collagen-containing sponges as drug delivery for proteins |
US5456711A (en) | 1992-05-15 | 1995-10-10 | Intervascular Inc. | Warp knitted carotid patch having finished selvedged edges |
US5766246A (en) | 1992-05-20 | 1998-06-16 | C. R. Bard, Inc. | Implantable prosthesis and method and apparatus for loading and delivering an implantable prothesis |
US5428022A (en) | 1992-07-29 | 1995-06-27 | Collagen Corporation | Composition of low type III content human placental collagen |
US5339657A (en) | 1992-09-01 | 1994-08-23 | Mcmurray Fabrics, Inc. | Net having different size openings and method of making |
WO1994006460A1 (en) | 1992-09-21 | 1994-03-31 | Vitaphore Corporation | Embolization plugs for blood vessels |
CZ281454B6 (en) | 1992-11-23 | 1996-10-16 | Milan Mudr. Csc. Krajíček | Aid for non-surgical closing of a hole in a vessel wall |
US5667839A (en) | 1993-01-28 | 1997-09-16 | Collagen Corporation | Human recombinant collagen in the milk of transgenic animals |
US6653450B1 (en) | 1993-01-28 | 2003-11-25 | Cohesion Technologies, Inc. | Mutated recombinant collagens |
US5356432B1 (en) | 1993-02-05 | 1997-02-04 | Bard Inc C R | Implantable mesh prosthesis and method for repairing muscle or tissue wall defects |
US5368602A (en) | 1993-02-11 | 1994-11-29 | De La Torre; Roger A. | Surgical mesh with semi-rigid border members |
US5433996A (en) | 1993-02-18 | 1995-07-18 | W. L. Gore & Associates, Inc. | Laminated patch tissue repair sheet material |
US6001895A (en) | 1993-03-22 | 1999-12-14 | Johnson & Johnson Medical, Inc. | Composite surgical material |
US5565210A (en) | 1993-03-22 | 1996-10-15 | Johnson & Johnson Medical, Inc. | Bioabsorbable wound implant materials |
US6015844A (en) | 1993-03-22 | 2000-01-18 | Johnson & Johnson Medical, Inc. | Composite surgical material |
US5942278A (en) | 1993-03-31 | 1999-08-24 | Nycomed Arzneimittel Gmbh | Process for the production of a material for sealing and healing wounds |
GB9306812D0 (en) | 1993-04-01 | 1993-05-26 | Vascutek Ltd | Textile prostheses |
FR2704139B1 (en) | 1993-04-23 | 1995-08-04 | Jean Claude Sgro | PROSTHETIC ASSEMBLY IN TEXTILE MATERIAL. |
DE4316673C1 (en) | 1993-05-12 | 1995-01-12 | Ethicon Gmbh | Flexible implant |
JP3542170B2 (en) | 1993-08-06 | 2004-07-14 | 株式会社アムニオテック | Medical material and method for producing the same |
US5607590A (en) | 1993-08-06 | 1997-03-04 | Shimizu; Yasuhiko | Material for medical use and process for preparing same |
US5487895A (en) | 1993-08-13 | 1996-01-30 | Vitaphore Corporation | Method for forming controlled release polymeric substrate |
FR2709947B1 (en) | 1993-09-13 | 1995-11-10 | Bard Sa Laboratoires | Curved prosthetic mesh and its manufacturing process. |
GB2281861B (en) | 1993-09-21 | 1997-08-20 | Johnson & Johnson Medical | Bioabsorbable wound implant materials containing microspheres |
GB2282328B (en) | 1993-09-29 | 1997-10-08 | Johnson & Johnson Medical | Absorbable structures for ligament and tendon repair |
US5686115A (en) | 1993-12-01 | 1997-11-11 | Marine Polymer Technologies, Inc. | Poly-β-1→4-N-acetylucosamine copolymer composition with collagen |
GB9400163D0 (en) | 1994-01-06 | 1994-03-02 | Geistlich Soehne Ag | Membrane |
FR2715309B1 (en) | 1994-01-24 | 1996-08-02 | Imedex | Adhesive composition, for surgical use, based on collagen modified by oxidative cutting and not crosslinked. |
FR2715405B1 (en) | 1994-01-24 | 1996-04-05 | Imedex | Process for the elimination of prions in collagens and collagens thus obtained. |
US5441491A (en) | 1994-02-04 | 1995-08-15 | Verschoor; Jacob | Method and composition for treating biopsy wounds |
US6334872B1 (en) | 1994-02-18 | 2002-01-01 | Organogenesis Inc. | Method for treating diseased or damaged organs |
US6113623A (en) * | 1994-04-20 | 2000-09-05 | Cabinet Beau De Lomenie | Prosthetic device and method for eventration repair |
US20030086975A1 (en) | 2001-11-08 | 2003-05-08 | Timothy Ringeisen | Method for making a porous Polymeric material |
US5601571A (en) | 1994-05-17 | 1997-02-11 | Moss; Gerald | Surgical fastener implantation device |
US5425740A (en) | 1994-05-17 | 1995-06-20 | Hutchinson, Jr.; William B. | Endoscopic hernia repair clip and method |
FR2720266B1 (en) | 1994-05-27 | 1996-12-20 | Cogent Sarl | Prosthetic fabric. |
IL110367A (en) | 1994-07-19 | 2007-05-15 | Colbar Lifescience Ltd | Collagen-based matrix |
GB9415125D0 (en) | 1994-07-27 | 1994-09-14 | Notaras Mitchell J | Surgical product and its use |
US5681568A (en) | 1994-08-19 | 1997-10-28 | Cambridge Neuroscience, Inc. | Device for delivery of substances and methods of use thereof |
US5899909A (en) | 1994-08-30 | 1999-05-04 | Medscand Medical Ab | Surgical instrument for treating female urinary incontinence |
US5931165A (en) | 1994-09-06 | 1999-08-03 | Fusion Medical Technologies, Inc. | Films having improved characteristics and methods for their preparation and use |
JP2987064B2 (en) | 1994-09-12 | 1999-12-06 | グンゼ株式会社 | Artificial dura |
FR2724563A1 (en) | 1994-09-15 | 1996-03-22 | Coletica | USE OF COLLAGENIC MEMBRANES AS PERITONEAL REGENERATION PROSTHESES |
JP2858087B2 (en) | 1994-09-19 | 1999-02-17 | グンゼ株式会社 | Tissue culture substrate and tissue culture method |
JPH08196538A (en) | 1994-09-26 | 1996-08-06 | Ethicon Inc | Tissue sticking apparatus for surgery with elastomer component and method of attaching mesh for surgery to said tissue |
US6171318B1 (en) | 1994-09-29 | 2001-01-09 | Bard Asdi Inc. | Hernia mesh patch with stiffening layer |
US5916225A (en) | 1994-09-29 | 1999-06-29 | Surgical Sense, Inc. | Hernia mesh patch |
US5769864A (en) | 1994-09-29 | 1998-06-23 | Surgical Sense, Inc. | Hernia mesh patch |
US6176863B1 (en) | 1994-09-29 | 2001-01-23 | Bard Asdi Inc. | Hernia mesh patch with I-shaped filament |
US6174320B1 (en) | 1994-09-29 | 2001-01-16 | Bard Asdi Inc. | Hernia mesh patch with slit |
US6280453B1 (en) | 1994-09-29 | 2001-08-28 | Bard Asdi Inc. | Hernia mesh patch with stiffener line segment |
US5634931A (en) | 1994-09-29 | 1997-06-03 | Surgical Sense, Inc. | Hernia mesh patches and methods of their use |
US6290708B1 (en) | 1994-09-29 | 2001-09-18 | Bard Asdi Inc. | Hernia mesh patch with seal stiffener |
US6294202B1 (en) | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
US6063396A (en) | 1994-10-26 | 2000-05-16 | Houston Biotechnology Incorporated | Methods and compositions for the modulation of cell proliferation and wound healing |
IT1275080B (en) | 1994-11-09 | 1997-07-30 | Gabriele Valenti | DYNAMIC PROSTHESIS IN DOUBLE LAYER FOR SURGICAL TREATMENT OF INGUINAL HERNIA |
BE1008955A3 (en) | 1994-11-14 | 1996-10-01 | Univ Catholique Louvain | Process for obtaining and products obtained biomaterials. |
US5891558A (en) | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
US5709934A (en) | 1994-11-22 | 1998-01-20 | Tissue Engineering, Inc. | Bipolymer foams having extracellular matrix particulates |
FR2728776B1 (en) | 1994-12-30 | 1997-07-18 | Cogent Sarl | PROSTHETIC ELEMENT FOR THE TREATMENT OF HERNIA OF THE GROWTH, PARTICULARLY BY COELIOSCOPIC |
US6080194A (en) | 1995-02-10 | 2000-06-27 | The Hospital For Joint Disease Orthopaedic Institute | Multi-stage collagen-based template or implant for use in the repair of cartilage lesions |
JP3543869B2 (en) | 1995-03-07 | 2004-07-21 | 株式会社メニコン | Cultured skin and method for producing the same |
AUPN174495A0 (en) | 1995-03-15 | 1995-04-06 | Ketharanathan, Vettivetpillai | Surgical prostheses |
US20020095218A1 (en) | 1996-03-12 | 2002-07-18 | Carr Robert M. | Tissue repair fabric |
US5911731A (en) | 1995-04-20 | 1999-06-15 | Target Therapeutics, Inc. | Anatomically shaped vasoocclusive devices |
GB2301362B (en) | 1995-05-30 | 1999-01-06 | Johnson & Johnson Medical | Absorbable implant materials having controlled porosity |
FR2735015B1 (en) | 1995-06-12 | 1998-02-13 | Microval | INTERNAL PROSTHESIS IN THE FORM OF A TEXTILE OR OTHER MEDIUM AND ITS COELIOSCOPIC INSERTION APPARATUS |
DE69630898T2 (en) | 1995-06-30 | 2004-08-26 | Boston Scientific Ltd., Saint Michael | Expansion-resistant vaso-occlusive spiral |
US5569273A (en) | 1995-07-13 | 1996-10-29 | C. R. Bard, Inc. | Surgical mesh fabric |
US5771716A (en) | 1995-09-18 | 1998-06-30 | Schlussel; Edward | Warp-knitted loop net fabric |
US5665391A (en) | 1995-10-12 | 1997-09-09 | Spectral Diagnostics Inc. | Cultured, full-thickness integument substitutes based on three-dimensional matrix membranes |
JPH09137380A (en) | 1995-11-10 | 1997-05-27 | Toray Ind Inc | Knit fabric of multilayer structure |
DE19544162C1 (en) | 1995-11-17 | 1997-04-24 | Ethicon Gmbh | Implant for suspension of the bladder in urinary incontinence in women |
CA2164262A1 (en) | 1995-12-01 | 1997-06-02 | Charles J. Doillon | Biostable porous material comprising composite biopolymers |
US6833408B2 (en) | 1995-12-18 | 2004-12-21 | Cohesion Technologies, Inc. | Methods for tissue repair using adhesive materials |
US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
CA2243193A1 (en) | 1996-01-29 | 1997-08-07 | Regen Drouin | Collagen and collagen-derived products free of any infectious agent, implants comprising the same and methods of making thereof |
FR2744906B1 (en) | 1996-02-21 | 1998-04-24 | Cousin Biotech | HERNIA REPAIR PLATE |
WO1997035533A1 (en) | 1996-03-25 | 1997-10-02 | Enrico Nicolo | Surgical mesh prosthetic material and methods of use |
DE19613730C2 (en) | 1996-03-26 | 2002-08-14 | Ethicon Gmbh | Flat implant for strengthening or closing body tissue |
US5876444A (en) | 1996-04-01 | 1999-03-02 | Lai; Wen-Fu | Reconstituted collagen template and the process to prepare the same |
US6132765A (en) | 1996-04-12 | 2000-10-17 | Uroteq Inc. | Drug delivery via therapeutic hydrogels |
US6143037A (en) | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US6706690B2 (en) | 1999-06-10 | 2004-03-16 | Baxter Healthcare Corporation | Hemoactive compositions and methods for their manufacture and use |
EP0827724A3 (en) | 1996-09-09 | 1998-05-06 | Herniamesh S.r.l. | Prosthesis for hernioplasty with preformed monofilament polypropylene mesh |
FR2754268B1 (en) | 1996-10-07 | 1998-12-24 | Dev Des Utilisations Du Collag | ADHESIVE COMPOSITION BASED ON MACROMOLECULAR POLYALDEHYDE AND METHOD FOR CROSSLINKING COLLAGEN OR GELATIN |
US5716409A (en) | 1996-10-16 | 1998-02-10 | Debbas; Elie | Reinforcement sheet for use in surgical repair |
FR2754705B1 (en) | 1996-10-18 | 1998-12-18 | Cogent Sarl | ANATOMICAL PROSTHESIS FOR THE REPAIR OF HERNIA BY LAPAROSCOPIC OR OPEN ROUTE |
TW501934B (en) | 1996-11-20 | 2002-09-11 | Tapic Int Co Ltd | Collagen material and process for making the same |
ES2238736T3 (en) | 1996-12-03 | 2005-09-01 | Osteobiologics, Inc. | BIODEGRADABLE POLYMER FILM. |
US6083522A (en) | 1997-01-09 | 2000-07-04 | Neucoll, Inc. | Devices for tissue repair and methods for preparation and use thereof |
US5814328A (en) | 1997-01-13 | 1998-09-29 | Gunasekaran; Subramanian | Preparation of collagen using papain and a reducing agent |
FR2759084B1 (en) | 1997-02-06 | 1999-10-29 | Dev Des Utilisations Du Collag | COLLAGENIC MATERIAL USEFUL IN PARTICULAR FOR THE PREVENTION OF POST-OPERATIVE ADHESIONS |
JP2001511685A (en) | 1997-02-13 | 2001-08-14 | ボストン サイエンティフィック リミテッド | Stabilized sling for use in minimally invasive pelvic surgery |
US6039686A (en) | 1997-03-18 | 2000-03-21 | Kovac; S. Robert | System and a method for the long term cure of recurrent urinary female incontinence |
FR2762207B1 (en) | 1997-04-17 | 1999-07-30 | Ethnor | IMPROVEMENTS ON SUBCUTANEOUS PROSTHESES FOR BREAST PLASTY |
US5922026A (en) | 1997-05-01 | 1999-07-13 | Origin Medsystems, Inc. | Surgical method and prosthetic strip therefor |
US6120539A (en) | 1997-05-01 | 2000-09-19 | C. R. Bard Inc. | Prosthetic repair fabric |
US5993844A (en) | 1997-05-08 | 1999-11-30 | Organogenesis, Inc. | Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix |
US6869938B1 (en) | 1997-06-17 | 2005-03-22 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use in reducing adhesions |
US6071292A (en) | 1997-06-28 | 2000-06-06 | Transvascular, Inc. | Transluminal methods and devices for closing, forming attachments to, and/or forming anastomotic junctions in, luminal anatomical structures |
US6066776A (en) | 1997-07-16 | 2000-05-23 | Atrium Medical Corporation | Self-forming prosthesis for repair of soft tissue defects |
FR2766698B1 (en) | 1997-08-01 | 1999-11-05 | Cogent Sarl | ADJUSTED THREE-DIMENSIONAL PROSTHETIC FABRIC |
FR2766716B1 (en) | 1997-08-01 | 2000-02-18 | Cogent Sarl | COMPOSITE PROSTHESIS FOR PREVENTION OF POST-SURGICAL ADHESIONS AND PROCESS FOR OBTAINING SAME |
US5980564A (en) | 1997-08-01 | 1999-11-09 | Schneider (Usa) Inc. | Bioabsorbable implantable endoprosthesis with reservoir |
FR2766717B1 (en) | 1997-08-01 | 2000-06-09 | Cogent Sarl | COMPOSITE PROSTHESIS FOR PREVENTION OF POST-SURGICAL ADHESIONS AND PROCESS FOR OBTAINING SAME |
US6042592A (en) | 1997-08-04 | 2000-03-28 | Meadox Medicals, Inc. | Thin soft tissue support mesh |
US6511958B1 (en) | 1997-08-14 | 2003-01-28 | Sulzer Biologics, Inc. | Compositions for regeneration and repair of cartilage lesions |
EP0896825B1 (en) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
US6241768B1 (en) | 1997-08-27 | 2001-06-05 | Ethicon, Inc. | Prosthetic device for the repair of a hernia |
JP2003510101A (en) | 1997-09-16 | 2003-03-18 | インテグラ・ライフサイエンスィーズ・コーポレーション | Collagen-containing products for promoting dural or meningeal tissue growth |
US5997895A (en) | 1997-09-16 | 1999-12-07 | Integra Lifesciences Corporation | Dural/meningeal repair product using collagen matrix |
GB2329840C (en) | 1997-10-03 | 2007-10-05 | Johnson & Johnson Medical | Biopolymer sponge tubes |
ATE248615T1 (en) | 1997-10-31 | 2003-09-15 | Childrens Medical Center | BLADDER RECONSTRUCTION |
FR2771623B1 (en) | 1997-11-28 | 2000-02-18 | Richard Cancel | DEVICE FOR THE PLACEMENT OF A PROSTHESIS IN THE TREATMENT OF GROWTH HERNIA BY COELIOSCOPICALLY |
US6008292A (en) | 1997-12-02 | 1999-12-28 | Baxter International Inc. | Method for inhibiting calcification of aldehyde-fixed bioprosthetic materials |
US6179872B1 (en) | 1998-03-17 | 2001-01-30 | Tissue Engineering | Biopolymer matt for use in tissue repair and reconstruction |
US6410044B1 (en) | 1998-03-19 | 2002-06-25 | Surmodics, Inc. | Crosslinkable macromers |
US6319264B1 (en) | 1998-04-03 | 2001-11-20 | Bionx Implants Oy | Hernia mesh |
US5910149A (en) | 1998-04-29 | 1999-06-08 | Kuzmak; Lubomyr I. | Non-slipping gastric band |
US6056970A (en) | 1998-05-07 | 2000-05-02 | Genzyme Corporation | Compositions comprising hemostatic compounds and bioabsorbable polymers |
US6428978B1 (en) | 1998-05-08 | 2002-08-06 | Cohesion Technologies, Inc. | Methods for the production of gelatin and full-length triple helical collagen in recombinant cells |
US6197934B1 (en) | 1998-05-22 | 2001-03-06 | Collagenesis, Inc. | Compound delivery using rapidly dissolving collagen film |
US6451301B1 (en) | 1998-06-08 | 2002-09-17 | Ferris Corporation | Analgesic and antinociceptive methods |
FR2779937B1 (en) | 1998-06-23 | 2000-08-11 | Sofradim Production | ADJUSTED ISOELASTIC PROSTHETIC FABRIC |
US6669735B1 (en) | 1998-07-31 | 2003-12-30 | Davol, Inc. | Prosthesis for surgical treatment of hernia |
FR2783429B1 (en) | 1998-09-18 | 2002-04-12 | Imedex Biomateriaux | BICOMPOSITE COLLAGENIC MATERIAL, ITS OBTAINING PROCESS AND ITS THERAPEUTIC APPLICATIONS |
US20030225355A1 (en) | 1998-10-01 | 2003-12-04 | Butler Charles E. | Composite material for wound repair |
WO2000022215A1 (en) | 1998-10-14 | 2000-04-20 | Asahi Doken Kabushiki Kaisha | 3-d structure net and composit structure material using the net |
FR2786400B1 (en) | 1998-11-30 | 2002-05-10 | Imedex Biomateriaux | PROCESS FOR THE PREPARATION OF A COLLAGENIC MATERIAL HAVING IN VIVO CONTROLLED BIODEGRADATION SPEED AND MATERIALS OBTAINED |
US6454787B1 (en) | 1998-12-11 | 2002-09-24 | C. R. Bard, Inc. | Collagen hemostatic foam |
EP1022031B1 (en) | 1999-01-21 | 2005-03-23 | Nipro Corporation | Suturable adhesion-preventing membrane |
WO2000047129A2 (en) | 1999-02-11 | 2000-08-17 | The General Hospital Corporation | Microfabricated membranes and matrices |
DE19912648A1 (en) | 1999-03-20 | 2000-09-21 | Aesculap Ag & Co Kg | Flat implant, method for its production and use in surgery |
US6287316B1 (en) | 1999-03-26 | 2001-09-11 | Ethicon, Inc. | Knitted surgical mesh |
US6391333B1 (en) | 1999-04-14 | 2002-05-21 | Collagen Matrix, Inc. | Oriented biopolymeric membrane |
EP1052319A1 (en) | 1999-05-03 | 2000-11-15 | Malden Mills Industries, Inc. | Three-dimensional composite fabric articles |
US6258124B1 (en) | 1999-05-10 | 2001-07-10 | C. R. Bard, Inc. | Prosthetic repair fabric |
US6656206B2 (en) | 1999-05-13 | 2003-12-02 | Cardia, Inc. | Occlusion device with non-thrombogenic properties |
US6383201B1 (en) | 1999-05-14 | 2002-05-07 | Tennison S. Dong | Surgical prosthesis for repairing a hernia |
FR2801313A1 (en) | 1999-05-19 | 2001-05-25 | Coletica | COLLAGENIC PRODUCT CONTAINING COLLAGEN OF MARINE ORIGIN WITH LOW ODOR AND PREFERREDLY WITH IMPROVED MECHANICAL PROPERTIES, AS WELL AS ITS USE IN THE FORM OF COMPOSITIONS OR COSMETIC OR PHARMACEUTICAL PRODUCTS |
ATE334639T1 (en) | 1999-06-08 | 2006-08-15 | Ethicon Inc | SURGICAL KNITTED FABRIC |
US6306424B1 (en) | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
JP5133482B2 (en) | 1999-07-21 | 2013-01-30 | イムデ ビオマテリオー | Adhesive protein foam for surgical and / or therapeutic use, and methods and kits for its production |
DE19942611C1 (en) | 1999-08-31 | 2001-07-05 | Ethicon Gmbh | Reinforced flat implant |
US6221109B1 (en) | 1999-09-15 | 2001-04-24 | Ed. Geistlich Söhne AG fur Chemische Industrie | Method of protecting spinal area |
US6312474B1 (en) | 1999-09-15 | 2001-11-06 | Bio-Vascular, Inc. | Resorbable implant materials |
US6592625B2 (en) | 1999-10-20 | 2003-07-15 | Anulex Technologies, Inc. | Spinal disc annulus reconstruction method and spinal disc annulus stent |
EP1267762A4 (en) | 1999-11-15 | 2005-05-25 | Texas A & M Univ Sys | Wound sealant formed in situ |
US6302897B1 (en) | 1999-11-19 | 2001-10-16 | Ethicon, Inc. | Device for deploying medical textiles |
EP1184499A4 (en) | 1999-12-16 | 2003-02-19 | Asahi Doken Kabushiki Kaisha | Three-dimensional maquisette style knitted fabric |
US6623963B1 (en) | 1999-12-20 | 2003-09-23 | Verigen Ag | Cellular matrix |
US6566345B2 (en) | 2000-04-28 | 2003-05-20 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
US6436030B2 (en) | 2000-01-31 | 2002-08-20 | Om P. Rehil | Hiatal hernia repair patch and method for using the same |
AU2000231660A1 (en) | 2000-03-09 | 2001-09-17 | Syntacoll Ag | Multilayer collagen matrix for tissue reconstruction |
US6723335B1 (en) | 2000-04-07 | 2004-04-20 | Jeffrey William Moehlenbruck | Methods and compositions for treating intervertebral disc degeneration |
US6682760B2 (en) | 2000-04-18 | 2004-01-27 | Colbar R&D Ltd. | Cross-linked collagen matrices and methods for their preparation |
DE10019604C2 (en) | 2000-04-20 | 2002-06-27 | Ethicon Gmbh | implant |
FR2807936B1 (en) | 2000-04-20 | 2002-08-02 | Sofradim Production | ABDOMINAL WALL REINFORCEMENT FOR THE TREATMENT OF INGUINAL HERNIA BY ANTERIOR VOLTAGE-FREE |
FR2809412A1 (en) | 2000-05-26 | 2001-11-30 | Coletica | Use of aquatic collagen for making supports for tissue engineering, particularly skin or tissue equivalents for surgical repair, studying aging processes and screening |
US6790454B1 (en) | 2000-05-26 | 2004-09-14 | Coletica | Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained |
US6974679B2 (en) | 2000-05-26 | 2005-12-13 | Coletica | Support with collagen base for tissue engineering and manufacture of biomaterials |
US6610006B1 (en) | 2000-07-25 | 2003-08-26 | C. R. Bard, Inc. | Implantable prosthesis |
US8366787B2 (en) | 2000-08-04 | 2013-02-05 | Depuy Products, Inc. | Hybrid biologic-synthetic bioabsorbable scaffolds |
US6743435B2 (en) | 2000-08-28 | 2004-06-01 | Collagen Matrix Technologies, Inc. | Processing animal tissues by decellularizing, increasing surface area and acylating |
US6773723B1 (en) | 2000-08-30 | 2004-08-10 | Depuy Acromed, Inc. | Collagen/polysaccharide bilayer matrix |
DE10043396C1 (en) | 2000-09-04 | 2002-06-20 | Ethicon Gmbh | Flexible implant |
US7025063B2 (en) | 2000-09-07 | 2006-04-11 | Ams Research Corporation | Coated sling material |
US20020084178A1 (en) | 2000-12-19 | 2002-07-04 | Nicast Corporation Ltd. | Method and apparatus for manufacturing polymer fiber shells via electrospinning |
US6852330B2 (en) | 2000-12-21 | 2005-02-08 | Depuy Mitek, Inc. | Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
CA2365376C (en) | 2000-12-21 | 2006-03-28 | Ethicon, Inc. | Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration |
US7192604B2 (en) | 2000-12-22 | 2007-03-20 | Ethicon, Inc. | Implantable biodegradable devices for musculoskeletal repair or regeneration |
US6500464B2 (en) | 2000-12-28 | 2002-12-31 | Ortec International, Inc. | Bilayered collagen construct |
US7041868B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Bioabsorbable wound dressing |
US7229453B2 (en) | 2001-01-23 | 2007-06-12 | Ams Research Corporation | Pelvic floor implant system and method of assembly |
US7098315B2 (en) | 2001-01-25 | 2006-08-29 | Nycomed Pharma As | Method of preparing a collagen sponge, a device for extracting a part of a collagen foam, and an elongated collagen sponge |
US6783554B2 (en) | 2001-02-20 | 2004-08-31 | Atrium Medical Corporation | Pile mesh prosthesis |
GB0108088D0 (en) | 2001-03-30 | 2001-05-23 | Browning Healthcare Ltd | Surgical implant |
CA2442315A1 (en) | 2001-04-02 | 2002-10-17 | Netech Inc. | Glycosaminoglycan/collagen complexes and use thereof |
US6719795B1 (en) | 2001-04-25 | 2004-04-13 | Macropore Biosurgery, Inc. | Resorbable posterior spinal fusion system |
US6575988B2 (en) | 2001-05-15 | 2003-06-10 | Ethicon, Inc. | Deployment apparatus for supple surgical materials |
CA2452040C (en) | 2001-06-29 | 2011-03-22 | Cook Biotech Incorporated | Porous sponge matrix medical devices and methods |
US6554855B1 (en) | 2001-07-03 | 2003-04-29 | Scimed Life Systems, Inc. | Low profile, high stretch, low dilation knit prosthetic device |
US6540773B2 (en) | 2001-07-03 | 2003-04-01 | Scimed Life Systems, Inc. | Low profile, high stretch knit prosthetic device |
DE10135275A1 (en) | 2001-07-13 | 2003-01-30 | Jotec Gmbh | Implant and process for its manufacture |
US6613348B1 (en) | 2001-07-31 | 2003-09-02 | Manoj K. Jain | Process of controlling absorbency in collagen flakes |
FR2829922B1 (en) | 2001-09-21 | 2004-06-18 | Sofradim Production | COMPLETE AND UNIVERSAL IMPLANT FOR THE REPAIR OF HERNIA BY ANTERIOR |
FR2830434B1 (en) * | 2001-10-05 | 2004-01-02 | Sofradim Production | THREE-DIMENSIONAL TRICOT WALL REINFORCEMENT AND ADJUSTMENT |
US6800082B2 (en) | 2001-10-19 | 2004-10-05 | Ethicon, Inc. | Absorbable mesh device |
DE10152407A1 (en) | 2001-10-24 | 2003-05-08 | Aesculap Ag & Co Kg | Composition of at least two biocompatible chemically crosslinkable components |
DE10155842A1 (en) | 2001-11-14 | 2003-05-28 | Ethicon Gmbh | Flat implant |
US6790213B2 (en) | 2002-01-07 | 2004-09-14 | C.R. Bard, Inc. | Implantable prosthesis |
US7303814B2 (en) | 2002-02-21 | 2007-12-04 | Encelle, Inc. | Immobilized bioactive hydrogel matrices as surface coatings |
US6755868B2 (en) | 2002-03-22 | 2004-06-29 | Ethicon, Inc. | Hernia repair device |
DE10221320A1 (en) | 2002-05-07 | 2003-11-27 | Gfe Medizintechnik Gmbh | Flat implant made of textile thread material, especially hernia mesh |
US6736823B2 (en) | 2002-05-10 | 2004-05-18 | C.R. Bard, Inc. | Prosthetic repair fabric |
WO2003101501A1 (en) | 2002-06-03 | 2003-12-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A multi-layer collagenic article useful for wounds healing |
US20050137512A1 (en) | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
US20040101546A1 (en) | 2002-11-26 | 2004-05-27 | Gorman Anne Jessica | Hemostatic wound dressing containing aldehyde-modified polysaccharide and hemostatic agents |
WO2004004600A1 (en) | 2002-07-04 | 2004-01-15 | Gyne Ideas Ltd | Medical implant |
DE10231975A1 (en) | 2002-07-15 | 2004-02-05 | Serag-Wiessner Kg | Implantable textile fabric |
GB2390856A (en) | 2002-07-16 | 2004-01-21 | Alcare Co Ltd | Warp-knit stretch fabric for medical use |
AU2003249310A1 (en) | 2002-07-17 | 2004-02-02 | Proxy Biomedical Limited | Soft tissue implants and methods for making same |
US7101381B2 (en) | 2002-08-02 | 2006-09-05 | C.R. Bard, Inc. | Implantable prosthesis |
US8142515B2 (en) | 2002-11-04 | 2012-03-27 | Sofradim Production | Prosthesis for reinforcement of tissue structures |
EP1572259A2 (en) | 2002-12-05 | 2005-09-14 | Cardio Incorporated | Layered bioresorbable implant |
CA2509622C (en) | 2002-12-16 | 2012-02-21 | Gunze Limited | Medical film comprising gelatin and reinforcing material |
EP1592361A2 (en) | 2003-02-11 | 2005-11-09 | C.R. Bard, Inc. | Implantable hernia repair system |
WO2004078120A2 (en) | 2003-02-28 | 2004-09-16 | Fibrogen, Inc. | Collagen compositions and biomaterials |
US8197837B2 (en) | 2003-03-07 | 2012-06-12 | Depuy Mitek, Inc. | Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof |
US20060216320A1 (en) | 2003-03-31 | 2006-09-28 | Eiichi Kitazono | Composite of support matrix and collagen, and process for producing support substrate and composite |
US20060135921A1 (en) | 2003-04-04 | 2006-06-22 | Wiercinski Robert A | Porous particulate collagen sponges |
US6949625B2 (en) | 2003-05-12 | 2005-09-27 | Khorionyx | Injectable implant of insoluble globin |
ES2220213B1 (en) | 2003-05-20 | 2006-01-16 | Juan Manuel Bellon Caneiro | DOUBLE MESH COMPOSITE PROTESIS THAT CORRECTES ABDOMINAL WALL DEFECTS, AND PREVENTS THE FORMATION OF ADHERENCES IN THE PERITONEAL INTERFACE. |
US8834864B2 (en) | 2003-06-05 | 2014-09-16 | Baxter International Inc. | Methods for repairing and regenerating human dura mater |
BRPI0410919B8 (en) | 2003-06-05 | 2021-06-22 | Baxter Healthcare Sa | use of an equine collagen foil |
US6974862B2 (en) | 2003-06-20 | 2005-12-13 | Kensey Nash Corporation | High density fibrous polymers suitable for implant |
NL1023926C2 (en) | 2003-07-15 | 2005-01-18 | Univ Groningen | Prosthesis based on a fiber-reinforced hydrogel and method for manufacturing the prosthesis and its application. |
CN1826813A (en) | 2003-07-24 | 2006-08-30 | 皇家飞利浦电子股份有限公司 | Handling feature availability in a broadcast |
FI120333B (en) | 2003-08-20 | 2009-09-30 | Bioretec Oy | A porous medical device and a method of making it |
FR2859624B1 (en) * | 2003-09-16 | 2005-12-02 | Sofradim Production | PROTHETIC KNIT WITH VARIABLE PROPERTIES |
US20050085924A1 (en) | 2003-10-17 | 2005-04-21 | Darois Roger E. | Tissue infiltratable prosthetic device incorporating an antimicrobial substance |
US20050113849A1 (en) | 2003-11-26 | 2005-05-26 | Nicholas Popadiuk | Prosthetic repair device |
FR2863277B1 (en) | 2003-12-05 | 2006-06-16 | Analytic Biosurgical Solutions | CHAIN KNIT FOR SURGICAL USE |
US20050142161A1 (en) | 2003-12-30 | 2005-06-30 | Freeman Lynetta J. | Collagen matrix for soft tissue augmentation |
US20050148963A1 (en) | 2004-01-05 | 2005-07-07 | Brennan H. G. | Bioabsorbable surgical sponge |
US20050175659A1 (en) | 2004-02-09 | 2005-08-11 | Macomber Laurel R. | Collagen device and method of preparing the same |
BRPI0510042B8 (en) | 2004-04-20 | 2021-06-22 | Genzyme Corp | implant similar to surgical mesh |
US20050267521A1 (en) | 2004-05-13 | 2005-12-01 | St. Jude Medical Puerto Rico B.V. | Collagen sponge for arterial sealing |
US20050288691A1 (en) | 2004-06-28 | 2005-12-29 | Leiboff Arnold R | Hernia patch |
FR2873700B1 (en) | 2004-07-29 | 2006-11-24 | Centre Nat Rech Scient Cnrse | PROCESS FOR THE CONTROLLED OXIDATION OF POLYSACCHARIDES |
JP4076525B2 (en) | 2004-08-06 | 2008-04-16 | Ykk株式会社 | Knitted surface fastener |
JP4934036B2 (en) | 2004-08-17 | 2012-05-16 | タイコ ヘルスケア グループ リミテッド パートナーシップ | Anti-adhesion barrier |
DE102004051487A1 (en) * | 2004-10-21 | 2006-04-27 | Ethicon Gmbh | Surgical implant, useful for closing and covering soft tissue defects, e.g. for hernia repair, comprises a flat base having projections able to absorb body fluids |
FR2884706B1 (en) | 2005-04-22 | 2008-04-04 | Sofradim Production Sa | PROTHETIC KNIT FOR SUPPORT IMPLANTS |
FR2889449B1 (en) | 2005-08-05 | 2011-06-10 | Khorionyx | IMPLANTABLE PREPARATIONS |
US7429241B2 (en) | 2005-09-29 | 2008-09-30 | Codman & Shurtleff, Inc. | Dural graft and method of preparing the same |
CA2626460A1 (en) | 2005-10-18 | 2007-04-26 | Organogenesis, Inc. | Antimicrobial collagenous constructs |
WO2007082295A2 (en) | 2006-01-12 | 2007-07-19 | Integra Lifesciences Corporation | Suturable dural and meningeal repair product comprising collagen matrix |
US20070299538A1 (en) | 2006-06-26 | 2007-12-27 | Roeber Peter J | Ease of use tissue repair patch |
US8709094B2 (en) | 2006-06-26 | 2014-04-29 | DePuy Synthes Products, LLC | Anti-adhesion sheet |
FR2912761B1 (en) * | 2007-02-15 | 2009-05-08 | Sofradim Production Sa | PROTHETIC KNIT FOR THE TREATMENT OF PROLAPSUS |
US20090036907A1 (en) | 2007-07-30 | 2009-02-05 | Yves Bayon | Bioresorbable knit |
FR2924330B1 (en) | 2007-12-03 | 2009-11-20 | Sofradim Production | IMPLANT FOR HERNIE PARASTOMIALE |
ES2559228T3 (en) * | 2008-12-15 | 2016-02-11 | Allergan, Inc. | A prosthetic device and a method to manufacture it |
-
2012
- 2012-09-25 FR FR1258973A patent/FR2995778B1/en not_active Expired - Fee Related
-
2013
- 2013-09-25 WO PCT/EP2013/069953 patent/WO2014048981A1/en active Application Filing
- 2013-09-25 EP EP13770675.0A patent/EP2900855B1/en active Active
- 2013-09-25 US US14/421,222 patent/US9499927B2/en active Active
-
2016
- 2016-11-21 US US15/357,436 patent/US20170065392A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5326150A (en) * | 1988-09-22 | 1994-07-05 | General Motors Corporation | Upholstery fabric |
US6151926A (en) * | 1998-06-30 | 2000-11-28 | Lear Corporation | Vehicle seat cover |
US6397638B1 (en) * | 1998-10-09 | 2002-06-04 | Stefan Achter | Method for integrating fasteners into a knitted seat cover and seat cover with fasteners |
US9499927B2 (en) * | 2012-09-25 | 2016-11-22 | Sofradim Production | Method for producing a prosthesis for reinforcing the abdominal wall |
Also Published As
Publication number | Publication date |
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EP2900855A1 (en) | 2015-08-05 |
EP2900855B1 (en) | 2019-08-21 |
US20150218738A1 (en) | 2015-08-06 |
FR2995778A1 (en) | 2014-03-28 |
FR2995778B1 (en) | 2015-06-26 |
WO2014048981A1 (en) | 2014-04-03 |
US9499927B2 (en) | 2016-11-22 |
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