US20160333300A1 - Packaging for a flexible container and transport unit - Google Patents
Packaging for a flexible container and transport unit Download PDFInfo
- Publication number
- US20160333300A1 US20160333300A1 US15/112,337 US201415112337A US2016333300A1 US 20160333300 A1 US20160333300 A1 US 20160333300A1 US 201415112337 A US201415112337 A US 201415112337A US 2016333300 A1 US2016333300 A1 US 2016333300A1
- Authority
- US
- United States
- Prior art keywords
- bottom part
- ceiling part
- ceiling
- container
- packaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/06—Liquids or semi-liquids or other materials or articles enclosed in flexible containers disposed within rigid containers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/26—Constructional details, e.g. recesses, hinges flexible
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- B01F15/0085—
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/071—Fixing of the stirrer to the shaft
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
- B01F27/0723—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis oblique with respect to the rotating axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/072—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis
- B01F27/0724—Stirrers characterised by their mounting on the shaft characterised by the disposition of the stirrers with respect to the rotating axis directly mounted on the rotating axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/07—Stirrers characterised by their mounting on the shaft
- B01F27/074—Stirrers characterised by their mounting on the shaft having two or more mixing elements being concentrically mounted on the same shaft
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/112—Stirrers characterised by the configuration of the stirrers with arms, paddles, vanes or blades
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
- B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/88—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with a separate receptacle-stirrer unit that is adapted to be coupled to a drive mechanism
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/91—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with propellers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
- B01F33/4531—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using an axis supported in several points for mounting the stirring element
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/50—Mixing receptacles
- B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
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- B01F7/00133—
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- B01F7/00141—
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- B01F7/22—
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B25/00—Packaging other articles presenting special problems
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B5/00—Packaging individual articles in containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, jars
- B65B5/04—Packaging single articles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D11/00—Containers having bodies formed by interconnecting or uniting two or more rigid, or substantially rigid, components made wholly or mainly of plastics material
- B65D11/18—Containers having bodies formed by interconnecting or uniting two or more rigid, or substantially rigid, components made wholly or mainly of plastics material collapsible, i.e. with walls hinged together or detachably connected
- B65D11/1866—Containers having bodies formed by interconnecting or uniting two or more rigid, or substantially rigid, components made wholly or mainly of plastics material collapsible, i.e. with walls hinged together or detachably connected with detachable components
- B65D11/1873—Containers having bodies formed by interconnecting or uniting two or more rigid, or substantially rigid, components made wholly or mainly of plastics material collapsible, i.e. with walls hinged together or detachably connected with detachable components all walls are detached from each other to collapse the container
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D19/00—Pallets or like platforms, with or without side walls, for supporting loads to be lifted or lowered
- B65D19/38—Details or accessories
- B65D19/385—Frames, corner posts or pallet converters, e.g. for facilitating stacking of charged pallets
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D19/00—Pallets or like platforms, with or without side walls, for supporting loads to be lifted or lowered
- B65D19/38—Details or accessories
- B65D19/40—Elements for spacing platforms from supporting surface
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/003—Articles enclosed in rigid or semi-rigid containers, the whole being wrapped
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
- B65D77/0446—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid or semi-rigid and the outer container being of polygonal cross-section not formed by folding or erecting one or more blanks
- B65D77/0453—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid or semi-rigid and the outer container being of polygonal cross-section not formed by folding or erecting one or more blanks the inner container having a polygonal cross-section
- B65D77/0466—Articles or materials enclosed in two or more containers disposed one within another the inner and outer containers being rigid or semi-rigid and the outer container being of polygonal cross-section not formed by folding or erecting one or more blanks the inner container having a polygonal cross-section the containers being mounted on a pallet
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/14—Bags
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation
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- B01F2215/0073—
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D2519/00—Pallets or like platforms, with or without side walls, for supporting loads to be lifted or lowered
- B65D2519/00004—Details relating to pallets
- B65D2519/00258—Overall construction
- B65D2519/00492—Overall construction of the side walls
- B65D2519/00532—Frame structures
Definitions
- This invention relates to a packaging for a flexible container, in particular for a disposable bag for use in a bioreactor. This invention furthermore relates to a transport unit with a flexible container which is received in such packaging.
- pre-sterilized disposable bags which replace conventional culture vessels made of glass or stainless steel.
- the disposable bags already are equipped with a plurality of pre-mounted hoses.
- pre-sterilized stirring tools can be integrated into the bags, which via a magnetic body in the interior of the bag are coupled with the external stiffer motor of the bioreactor.
- U.S. Pat. No. 5,307,928 shows a transport packaging for household appliances which comprises an upper cover and a lower supporting device with a lower cover and four folded side elements in which the lateral edges of the appliance are accommodated.
- the upper cover, the lower cover and the side elements are fixed at the appliance by straps, in order to ensure a protection of the appliance against transport damages.
- an exterior packaging for a bioreactor bag which consists of a lid, a bottom and side walls.
- the exterior packaging includes a compartment for receiving the bioreactor bag, wherein the volume of the compartment is defined by a separating device with two gable walls running towards each other at an obtuse angle.
- the separating device is vertically shiftably arranged within the exterior packaging, so that the volume of the compartment can variably be adapted to different volumes of bioreactor bags.
- the inventive packaging for a flexible container in particular for a disposable bag for use in a bioreactor, comprises a bottom part for fixing a first portion of the container, a ceiling part for fixing an opposite second portion of the container, a receiving space which on a first side is defined by the bottom part and on an opposite second side is defined by the ceiling part, and struts arranged between the bottom part and the ceiling part, which fix a defined distance between the bottom part and the ceiling part.
- the struts provided according to the invention serve as spacers between the bottom part and the ceiling part and hence define the height of the receiving space. With a knowledge of the dimensions of the container to be transported it thereby is possible to choose the distance between the bottom part and the ceiling part so large that in the transport condition the container fixed at these parts permanently is held in an unfolded condition, in which a pressure or frictional contact of the flexible container envelope with internal parts, such as a stirring tool, largely is excluded.
- the struts ensure that the packaging becomes a kind of frame in which the receiving space altogether has such a large volume that the flexible container envelope virtually always has a possibility for backing away from a contact with a hard or sharp-edged part.
- the struts As compared to smooth side walls, as they are provided for example in the packaging according to WO 2013/171340 A2, the struts have the advantage that they are easier to grasp. This means that the packaging frame is easier to manipulate (carry, tilt, turn etc.) both during packaging and during unpacking. In the same advantageous way, the packaging according to the invention also can serve as packaging for storing the container before or after a transport.
- bottom part and “ceiling part” were chosen with regard to the preferred application of the invention, in which the orientations of the packaging and the flexible container play an important role, which will be discussed in more detail below.
- the terms are not to be understood in a limiting sense.
- the bottom part need not necessarily be arranged at the bottom and the ceiling part need not necessarily be arranged at the top.
- the two parts also can represent side parts.
- the preferred material for the bottom part and/or the ceiling part is foamed material, not only because of the low density. From foamed material arbitrary shapes can be made, wherein the strength and compressibility are adaptable to the respective requirements.
- At least one compartment is formed in the bottom part and/or in the ceiling part, which is accessible from the receiving space via at least one passage opening.
- Such compartment serves for receiving one or more hoses which are connected to the container.
- the respective hose is guided through the passage opening, so that most of the hose comes to lie in the compartment. Due to the spatial separation of the compartment from the receiving space, in which the container is accommodated, pressure or frictional contacts between container envelope and hose can be excluded.
- pressure or frictional contacts between container envelope and hose can be excluded.
- due to the specified guidance and placement of a hose in a separate compartment kinking of the hose can be avoided. This can be supported by further measures, such as rolling up and fixing of the hose portion present in the compartment.
- the bottom part and/or the ceiling part includes a lower plate and an upper plate, which are separated from each other by one or more spacer elements, wherein the at least one compartment is defined by the plates and the spacer element(s). Due to the spaced arrangement of two plates one above the other a free space is obtained, in which the at least one compartment can be provided.
- the spacer elements at the same time serve as lateral boundaries of the compartment.
- the bottom part and/or the ceiling part has several passage openings which are each separately accessible from an outside of a plate of the bottom part and/or each separately from an outside of a plate of the ceiling part.
- the additional lateral accessibility of the passage openings provides for separately inserting the hoses into different passage openings and for stowing the same separately.
- a tangled mess of cables, more exactly a “mess of hoses” of several entangled hoses thereby is avoided, so that unpacking the container and putting the container with the hoses into operation can be carried out more comfortably.
- the bottom part and/or the ceiling part with the compartment formed therein either can be formed in one piece or be composed of several parts and be designed as prefabricated assembly. In both cases packaging is simplified, as the bottom part and/or the ceiling part immediately is usable as a whole without preparatory work.
- a plate of the bottom part or of the ceiling part includes an oblong slot which extends from an outside of the plate to the inside.
- a central discharge hose or other hose of a disposable bag to be packaged can be introduced laterally and be pulled to the center.
- the slot hence serves as passage opening for the hose, which then can be deposited on the side of the plate facing away from the receiving space.
- the slot merely serves as fixture for the bag.
- a spacer element includes a depression on the bottom part or ceiling part transversely to the longitudinal direction of the slot.
- the hose thus can be guided through the depression onto the side of the spacer element facing away from the slot and be deposited there, where it is safe from contacts with other parts of the container.
- a recess extending across the slot can be formed in the plate before the inner slot end, into which recess a separate retaining part is insertable.
- the retaining element represents a barrier for the hose and ensures a defined, kink-free course of the hose.
- both the bottom part and the ceiling part include opposite fixtures for the struts.
- a central receptacle in the bottom part or in the ceiling part is advantageous for a magnetic body of a mixing tool arranged in the container, which usually is arranged on an end portion of the container.
- At least one separate fixture part for fixing one or more hoses, which extend from the flexible container can be provided in the packaging.
- Such fixture parts ensure that there is no direct contact between hard or sharp-edged connectors, connecting pieces or other parts of the hoses and the flexible container. Undesired kinking of the hose portions which open into the container also is avoided by the fixation by means of the fixture parts.
- the fixture parts can flexibly be adapted to the respective hose designs in terms of shape, material etc., in order to ensure an optimum protection against damages of the container and the hoses.
- the fixture part for example can be designed such that at least one line receptacle in which at least one hose portion can be fixed is accessible via a passage.
- the hose portion thus can easily be introduced into the line receptacle and be clamped there and/or be held by friction.
- the invention also creates a transport unit with a flexible container, in particular a bag for use in a bioreactor, wherein the container is received in a packaging as described above.
- hoses are mounted on an upper portion of the container with respect to the intended position of use of the container, which hoses are guided through one or more passage openings of the bottom part or the ceiling part into the compartment(s).
- the required hoses already are mounted on corresponding connectors of the bag envelope and are delivered as unit. The majority of hoses opens into the upper portion of the bag, so that here especially it is required to stow the hoses orderly and safely.
- the one or more passage openings of the bottom part and/or of the ceiling part each are accessible separately from an outside of a plate of the bottom part and/or each separately from an outside of a plate of the ceiling part.
- the additional lateral accessibility of the passage openings provides for separately inserting the hoses into various passage openings and for separately stowing the same, whereby entangling of several hoses is avoided.
- each passage opening is connected with a separate compartment, so that a clear allocation of the passage openings to the compartments is ensured.
- a kink-free course of such hose is prevented in that the bottom part or the ceiling part includes at least two support elements on which the hose is deposited.
- the packaged container includes a shaft with a magnetic body of a mixing tool supported on an end of the shaft, which is inserted into a receptacle of the bottom part or the ceiling part.
- This receptacle offers an additional protection against the magnetic body undesirably getting in contact with the container envelope.
- FIG. 1 shows a perspective view of a packaging according to a first embodiment of the invention
- FIG. 2 shows a perspective view of the packaging of FIG. 1 with a disposable bag for a bioreactor as transport unit according to the invention
- FIG. 3 shows a perspective detail view of the ceiling part of the packaging of FIG. 1 ;
- FIG. 4 shows a fixture part of a packaging according to the invention for fixing hoses with connectors
- FIG. 5 shows the fixture part of FIG. 4 with fixed hoses
- FIG. 6 shows a perspective view of a packaging according to a second embodiment of the invention.
- FIG. 7 shows a perspective view of the packaging of FIG. 6 with a disposable bag for a bioreactor as transport unit according to the invention.
- FIGS. 1 and 2 show a first embodiment of a packaging 10 for a flexible container 12 , more exactly a disposable bag (see FIG. 2 ), which is provided for use in a bioreactor.
- the packaging 10 comprises a bottom part 14 , a ceiling part 16 and several column-like struts 18 which serve as spacers between the bottom part 14 and the ceiling part 16 .
- the space defined by the bottom part 14 , the ceiling part 16 and the struts 18 forms a receiving space 20 for the container 12 to be packaged.
- the longitudinal direction of the struts 18 subsequently is referred to as vertical direction and the directions vertical thereto, in which the bottom part 14 and the ceiling part 16 extend, are referred to as horizontal directions, corresponding to the preferred use of the packaging 10 , wherein these designations are not to be understood in a limiting sense.
- the bottom part 14 substantially consists of a foamed material and includes a lower base plate 22 and an upper base plate 24 , which are separated from each other by spacer elements 26 . Between the lower base plate 22 and the upper base plate 24 a free space thus is located, which is divided into several compartments 28 by the spacer elements 26 .
- a compartment 28 can laterally be closed completely or be connected with one or more adjacent compartments 28 . At least some of the compartments 28 are accessible from outside in horizontal direction.
- the upper base plate 24 has several vertical passage openings 30 through which the compartments 28 also are accessible in vertical direction.
- the passage openings 30 can have various shapes and dimensions depending on the requirement.
- the upper base plate 24 has several rectangular openings which are not closed on the outside, and a central receptacle 32 .
- the bottom part 14 can be formed in one piece or be composed of several individual parts. In the latter case, the individual parts are glued, braced, clamped, welded or otherwise connected to each other such that the bottom part 14 forms a prefabricated assembly and can be stored and moved as a whole.
- the ceiling part 16 is formed either in one piece or as prefabricated assembly and substantially consists of foamed material.
- a plurality of spacer elements 26 are arranged on the side facing away from the bottom part 14 , but no further plate for vertically delimiting the compartments indicated by the spacer elements.
- additional plate can, however, be provided optionally.
- the ceiling plate 34 has an oblong slot 36 as vertical passage opening 30 , which extends from an outside up to about the center of the ceiling plate 34 .
- a recess 40 extending transversely to the longitudinal direction of the slot 36 is formed in the ceiling plate 34 , which can be filled by a separate retaining part 42 (see FIG. 3 ).
- an oblong spacer element 44 likewise extends transversely to the longitudinal direction of the slot 36 .
- this spacer element 44 includes a depression 46 on its free side facing away from the ceiling plate 34 .
- the bottom part 14 , the ceiling part 16 and the struts 18 are fabricated of the same, gamma-sterilizable material, preferably polyethylene (PE).
- PE polyethylene
- said parts also can be formed of another stable and fracture-proof material.
- the bottom part 14 and the ceiling part 16 include opposite fixtures 48 for each strut 18 .
- the struts 18 are inserted into the fixtures 48 parallel to each other, a robust packaging frame is obtained, whose preferred use will be explained in more detail below.
- the fixture part 64 is of comb-like shape and has several line receptacles 66 which are accessible via constricted passages 68 .
- the container 12 to be packaged here is a pre-sterilized disposable bag with a flexible envelope 50 .
- the container 12 contains an integrated stirrer which includes several stirring tools 52 and a magnetic body 54 .
- the stirring tools 52 and the magnetic body 54 are mounted on a central shaft 56 .
- several fluid lines (hoses) (not shown in FIGS. 1 and 2 ) are connected to the container 12 .
- hoses are connected to the container 12 .
- the majority of these hoses is provided at the upper portion 58 of the container 12 .
- To the lower portion 60 of the container 12 a central discharge hose is connected. At least at some of the hoses connecting pieces, fixing clamps or other hard or sharp-edged elements are disposed.
- the container 12 initially is fixed with its upper end at the bottom part 14 of the packaging 10 , wherein the magnetic body 54 arranged at the upper shaft end is inserted into the central receptacle 32 of the upper base plate 24 .
- the hoses mounted at the upper portion 58 of the container 12 are guided through the respectively nearest passage opening 30 and received in the compartment 28 underneath.
- the hose portions present in the compartments 28 can be fixed in the rolled-up condition e.g. by clamps and/or be protected by wrapping or bagging.
- the struts 18 are inserted into the fixtures 48 of the bottom part 14 , and the container 12 is pulled upwards at the central discharge hose.
- the discharge hose is pulled to the center through the slot 36 in the ceiling plate 34 and guided over the depression 46 in the spacer element 44 , so that the remaining part of the discharge hose comes to lie on the ceiling plate 34 on the side facing away from the slot 36 .
- This hose part too, can be fixed in the rolled-up condition and be protected by further measures.
- the retaining part 42 is inserted into the recess 40 after the discharge hose has been pulled up to the slot end 38 .
- the retaining part 42 prevents that the discharge hose can be shifted to the outside. (When unpacking the container 12 later on, the retaining part 42 is again removed from the recess 40 ).
- the ceiling part 16 is put onto the struts 18 .
- the container 12 now is upside down with respect to its future condition of use, i.e. accommodated in the packaging 10 with its upper portion 58 at the bottom and its lower portion 60 at the top.
- the distance between the bottom part 14 and the ceiling part 16 as defined by the length of the struts 18 is chosen such that no or only a negligeable part of the fixed container 12 can protrude laterally from the packaging frame between the struts 18 .
- the separate fixture parts 64 still can be inserted, as shown in FIG. 5 .
- the fixture parts 64 serve to fix hoses extending from the flexible envelope 50 of the container 12 .
- the hoses are pressed through the passages 68 into the line receptacles 66 of the fixture parts 64 close to the envelope 50 . It thereby is achieved that those portions of the hoses which open into the container 12 are fixed such that they more or less vertically extend from the envelope 50 to the outside.
- This fixation ensures that hard or sharp-edged connectors, connecting pieces or other parts of the hoses are kept away from the flexible envelope 50 , in order to prevent damages at the envelope 50 itself, but also at the hoses and their connectors, connecting pieces etc.
- the packaging frame also is covered with one or two plastic sacks or the like, which are welded closed or closed with adhesive tape, before the entire unit then is put into a shipping carton and secured with strapping tapes or packing tape.
- the packaging 10 as shown in FIGS. 1 to 5 is suitable for large flexible containers 12 with a filling volume in the order of magnitude of 500 liters, 1,000 liters, 2,000 liters or more.
- FIGS. 6 and 7 show a second embodiment of the packaging 10 , which is suitable for smaller containers 12 with a filling volume in the order of magnitude of 50 liters or 200 liters.
- the second embodiment substantially has the same construction as the first embodiment and only differs in the dimensions of the individual elements and in the concrete design of the bottom part 14 and the ceiling part 16 .
- a single compartment 28 is formed in the bottom part, which however has a larger vertical height as compared to the first embodiment.
- a spacer element extending across the ceiling plate 34 and a separate retaining element are not provided in the ceiling part 16 .
- the ceiling part 16 instead includes two support elements 62 which are lower than the outer spacer elements 26 of the ceiling part 16 .
- the rolled up discharge hose comes to lie on these support elements 62 .
- the support elements 62 here ensure that kinking of the discharge hose is avoided.
- both embodiments have in common that the bottom parts 14 and the ceiling parts 16 each have a rectangular, particularly preferably a square basic shape. This shape however is not absolutely necessary, just like the number of struts 18 , i.e. depending on the requirement there can also be provided less (in particular three) or more than four struts 18 , wherein an arrangement outdoors always is preferred.
- the bottom part 14 and/or the ceiling part 16 also can include several intermediate trays with passage openings 30 , so that the compartments 28 for the hoses etc. also can be arranged one above the other.
- fixture parts 64 can also be provided in the second embodiment.
- the described embodiments each relate to a packaging 10 for a special disposable bag which is provided for use in a bioreactor.
- the invention is, however, not limited to this application. Rather, the packaging 10 according to the invention also can be used for other flexible containers or similar objects.
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Abstract
A packaging for a flexible container, in particular for a disposable bag for use in a bioreactor, comprises a bottom part for fixing a first portion of the container, a ceiling part for fixing an opposite second portion of the container, a receiving space which on a first side is defined by the bottom part and on an opposite second side is defined by the ceiling part, and struts arranged between the bottom part and the ceiling part, which fix a defined distance between the bottom part and the ceiling part.
Description
- This invention relates to a packaging for a flexible container, in particular for a disposable bag for use in a bioreactor. This invention furthermore relates to a transport unit with a flexible container which is received in such packaging.
- In bioreactors certain microorganisms or plant or animal cells are cultivated under conditions as optimum as possible. There are often used pre-sterilized disposable bags which replace conventional culture vessels made of glass or stainless steel. The disposable bags already are equipped with a plurality of pre-mounted hoses. In addition, pre-sterilized stirring tools can be integrated into the bags, which via a magnetic body in the interior of the bag are coupled with the external stiffer motor of the bioreactor.
- When transporting such disposable bags in ordinary packagings, it cannot be excluded that a damage of the bag can occur due to the contact of the bag with the stirring tools or other hard or sharp-edged parts of the hoses, such as hose clamps or other means for fixing the hoses in the rolled-up condition. This is due to the fact that the bag—based on its intended position of use—usually is folded, packed and transported in the horizontal position.
- U.S. Pat. No. 5,307,928 shows a transport packaging for household appliances which comprises an upper cover and a lower supporting device with a lower cover and four folded side elements in which the lateral edges of the appliance are accommodated. During the transport of the appliance the upper cover, the lower cover and the side elements are fixed at the appliance by straps, in order to ensure a protection of the appliance against transport damages.
- From WO 2013/171340 A2 an exterior packaging for a bioreactor bag is known, which consists of a lid, a bottom and side walls. The exterior packaging includes a compartment for receiving the bioreactor bag, wherein the volume of the compartment is defined by a separating device with two gable walls running towards each other at an obtuse angle. The separating device is vertically shiftably arranged within the exterior packaging, so that the volume of the compartment can variably be adapted to different volumes of bioreactor bags.
- It is the object of the invention to provide a packaging which provides for a safe transport and a safe storage of a flexible container, in particular in consideration of the hoses which are mounted on the container and are to be stowed in the packaging.
- This object is solved by a packaging with the features of
claim 1. Advantageous and expedient aspects of the packaging according to the invention are indicated in the associated sub-claims. - The inventive packaging for a flexible container, in particular for a disposable bag for use in a bioreactor, comprises a bottom part for fixing a first portion of the container, a ceiling part for fixing an opposite second portion of the container, a receiving space which on a first side is defined by the bottom part and on an opposite second side is defined by the ceiling part, and struts arranged between the bottom part and the ceiling part, which fix a defined distance between the bottom part and the ceiling part.
- The struts provided according to the invention serve as spacers between the bottom part and the ceiling part and hence define the height of the receiving space. With a knowledge of the dimensions of the container to be transported it thereby is possible to choose the distance between the bottom part and the ceiling part so large that in the transport condition the container fixed at these parts permanently is held in an unfolded condition, in which a pressure or frictional contact of the flexible container envelope with internal parts, such as a stirring tool, largely is excluded. In addition, the struts ensure that the packaging becomes a kind of frame in which the receiving space altogether has such a large volume that the flexible container envelope virtually always has a possibility for backing away from a contact with a hard or sharp-edged part. As compared to smooth side walls, as they are provided for example in the packaging according to WO 2013/171340 A2, the struts have the advantage that they are easier to grasp. This means that the packaging frame is easier to manipulate (carry, tilt, turn etc.) both during packaging and during unpacking. In the same advantageous way, the packaging according to the invention also can serve as packaging for storing the container before or after a transport.
- The terms “bottom part” and “ceiling part” were chosen with regard to the preferred application of the invention, in which the orientations of the packaging and the flexible container play an important role, which will be discussed in more detail below. However, the terms are not to be understood in a limiting sense. In other applications, the bottom part need not necessarily be arranged at the bottom and the ceiling part need not necessarily be arranged at the top. For example, the two parts also can represent side parts.
- The preferred material for the bottom part and/or the ceiling part is foamed material, not only because of the low density. From foamed material arbitrary shapes can be made, wherein the strength and compressibility are adaptable to the respective requirements.
- According to a particularly preferred embodiment of the invention at least one compartment is formed in the bottom part and/or in the ceiling part, which is accessible from the receiving space via at least one passage opening. Such compartment serves for receiving one or more hoses which are connected to the container. For packaging, the respective hose is guided through the passage opening, so that most of the hose comes to lie in the compartment. Due to the spatial separation of the compartment from the receiving space, in which the container is accommodated, pressure or frictional contacts between container envelope and hose can be excluded. In addition, due to the specified guidance and placement of a hose in a separate compartment kinking of the hose can be avoided. This can be supported by further measures, such as rolling up and fixing of the hose portion present in the compartment. As compared to a conventional packaging, unpacking of the container turns out to be easier, as each hose is found at a predetermined point. When several compartments are provided, in each of which only one hose is accommodated, entangling of the hoses thereby is prevented. It should be noted that the at least one compartment—apart from the at least one passage opening—need not be closed all around. Rather, the compartment should be accessible laterally, so that a hose can be placed therein or be removed therefrom more easily. In the case of several compartments, a compartment also can be connected with one or more adjacent compartments.
- Preferably, the bottom part and/or the ceiling part includes a lower plate and an upper plate, which are separated from each other by one or more spacer elements, wherein the at least one compartment is defined by the plates and the spacer element(s). Due to the spaced arrangement of two plates one above the other a free space is obtained, in which the at least one compartment can be provided. The spacer elements at the same time serve as lateral boundaries of the compartment.
- According to a particularly preferred embodiment of the invention the bottom part and/or the ceiling part has several passage openings which are each separately accessible from an outside of a plate of the bottom part and/or each separately from an outside of a plate of the ceiling part. The additional lateral accessibility of the passage openings provides for separately inserting the hoses into different passage openings and for stowing the same separately. A tangled mess of cables, more exactly a “mess of hoses” of several entangled hoses thereby is avoided, so that unpacking the container and putting the container with the hoses into operation can be carried out more comfortably.
- The bottom part and/or the ceiling part with the compartment formed therein either can be formed in one piece or be composed of several parts and be designed as prefabricated assembly. In both cases packaging is simplified, as the bottom part and/or the ceiling part immediately is usable as a whole without preparatory work.
- With regard to the preferred application of the packaging according to the invention a plate of the bottom part or of the ceiling part includes an oblong slot which extends from an outside of the plate to the inside. Into this slot a central discharge hose or other hose of a disposable bag to be packaged can be introduced laterally and be pulled to the center. The slot hence serves as passage opening for the hose, which then can be deposited on the side of the plate facing away from the receiving space. When the hose is rolled up and fixed on this side, so that the hose no longer can be pulled back into the receiving space, the slot merely serves as fixture for the bag.
- According to a particular embodiment of the invention a spacer element includes a depression on the bottom part or ceiling part transversely to the longitudinal direction of the slot. The hose thus can be guided through the depression onto the side of the spacer element facing away from the slot and be deposited there, where it is safe from contacts with other parts of the container.
- To prevent that the hose again moves from the slot end to the outside, a recess extending across the slot can be formed in the plate before the inner slot end, into which recess a separate retaining part is insertable. The retaining element represents a barrier for the hose and ensures a defined, kink-free course of the hose.
- For anchoring the struts, preferably both the bottom part and the ceiling part include opposite fixtures for the struts.
- In turn with regard to the preferred application of the invention, a central receptacle in the bottom part or in the ceiling part is advantageous for a magnetic body of a mixing tool arranged in the container, which usually is arranged on an end portion of the container.
- According to a development of the invention at least one separate fixture part for fixing one or more hoses, which extend from the flexible container, can be provided in the packaging. Such fixture parts ensure that there is no direct contact between hard or sharp-edged connectors, connecting pieces or other parts of the hoses and the flexible container. Undesired kinking of the hose portions which open into the container also is avoided by the fixation by means of the fixture parts. The fixture parts can flexibly be adapted to the respective hose designs in terms of shape, material etc., in order to ensure an optimum protection against damages of the container and the hoses.
- The fixture part for example can be designed such that at least one line receptacle in which at least one hose portion can be fixed is accessible via a passage. The hose portion thus can easily be introduced into the line receptacle and be clamped there and/or be held by friction.
- The invention also creates a transport unit with a flexible container, in particular a bag for use in a bioreactor, wherein the container is received in a packaging as described above.
- With respect to the advantages of this transport unit reference is made to the above explanations concerning the advantages of the packaging according to the invention.
- According to the preferred application of the invention several hoses are mounted on an upper portion of the container with respect to the intended position of use of the container, which hoses are guided through one or more passage openings of the bottom part or the ceiling part into the compartment(s). In a disposable bag for use in a bioreactor, the required hoses already are mounted on corresponding connectors of the bag envelope and are delivered as unit. The majority of hoses opens into the upper portion of the bag, so that here especially it is required to stow the hoses orderly and safely.
- Particularly preferably, the one or more passage openings of the bottom part and/or of the ceiling part each are accessible separately from an outside of a plate of the bottom part and/or each separately from an outside of a plate of the ceiling part. As explained already, the additional lateral accessibility of the passage openings provides for separately inserting the hoses into various passage openings and for separately stowing the same, whereby entangling of several hoses is avoided.
- Preferably, each passage opening is connected with a separate compartment, so that a clear allocation of the passage openings to the compartments is ensured.
- It is found to be advantageous to fix the container, with respect to its intended position of use, with an upper portion at the bottom part and with a lower portion at the ceiling part (upside down). As mentioned above, the majority of hoses is present at the upper portion of the container, just like e.g. a magnetic body for coupling the drive for the stirring tools. When the container then is packaged and transported upside down, the center of gravity of the container lies at the bottom and there is a much smaller risk of tilting of the transport unit.
- When packaging a disposable bag, in which (only) one central hose is mounted on a lower portion, with respect to the intended position of use, it is advantageous to guide the same through a passage opening of the ceiling part in the form of a slot into the at least one compartment.
- In a special embodiment a kink-free course of such hose is prevented in that the bottom part or the ceiling part includes at least two support elements on which the hose is deposited.
- According to a preferred embodiment the packaged container includes a shaft with a magnetic body of a mixing tool supported on an end of the shaft, which is inserted into a receptacle of the bottom part or the ceiling part. This receptacle offers an additional protection against the magnetic body undesirably getting in contact with the container envelope.
- In particular for a container which includes no shaft or other components that specify the height of the bag, it is expedient to adjust the arrangement and the lengths of the struts to the expansion of the received container in a first direction between the bottom part and the ceiling part such that in the directions vertical to the first direction the container does not or only slightly protrude between the struts. The less clearance the container has in these directions, the smaller is the risk of a damage.
- Further features and advantages of the invention can be taken from the following description and from the attached drawings to which reference is made. In the drawings:
-
FIG. 1 shows a perspective view of a packaging according to a first embodiment of the invention; -
FIG. 2 shows a perspective view of the packaging ofFIG. 1 with a disposable bag for a bioreactor as transport unit according to the invention; -
FIG. 3 shows a perspective detail view of the ceiling part of the packaging ofFIG. 1 ; -
FIG. 4 shows a fixture part of a packaging according to the invention for fixing hoses with connectors; -
FIG. 5 shows the fixture part ofFIG. 4 with fixed hoses; -
FIG. 6 shows a perspective view of a packaging according to a second embodiment of the invention; and -
FIG. 7 shows a perspective view of the packaging ofFIG. 6 with a disposable bag for a bioreactor as transport unit according to the invention. -
FIGS. 1 and 2 show a first embodiment of apackaging 10 for aflexible container 12, more exactly a disposable bag (seeFIG. 2 ), which is provided for use in a bioreactor. Thepackaging 10 comprises abottom part 14, aceiling part 16 and several column-like struts 18 which serve as spacers between thebottom part 14 and theceiling part 16. The space defined by thebottom part 14, theceiling part 16 and thestruts 18 forms a receivingspace 20 for thecontainer 12 to be packaged. - For the sake of simplicity, the longitudinal direction of the
struts 18 subsequently is referred to as vertical direction and the directions vertical thereto, in which thebottom part 14 and theceiling part 16 extend, are referred to as horizontal directions, corresponding to the preferred use of thepackaging 10, wherein these designations are not to be understood in a limiting sense. - The
bottom part 14 substantially consists of a foamed material and includes alower base plate 22 and anupper base plate 24, which are separated from each other byspacer elements 26. Between thelower base plate 22 and the upper base plate 24 a free space thus is located, which is divided intoseveral compartments 28 by thespacer elements 26. Acompartment 28 can laterally be closed completely or be connected with one or moreadjacent compartments 28. At least some of thecompartments 28 are accessible from outside in horizontal direction. - The
upper base plate 24 has severalvertical passage openings 30 through which thecompartments 28 also are accessible in vertical direction. Thepassage openings 30 can have various shapes and dimensions depending on the requirement. In the illustrated exemplary embodiment theupper base plate 24 has several rectangular openings which are not closed on the outside, and a central receptacle 32. - The
bottom part 14 can be formed in one piece or be composed of several individual parts. In the latter case, the individual parts are glued, braced, clamped, welded or otherwise connected to each other such that thebottom part 14 forms a prefabricated assembly and can be stored and moved as a whole. - Analogous to the
bottom part 14, theceiling part 16 is formed either in one piece or as prefabricated assembly and substantially consists of foamed material. On aceiling plate 34 of the ceiling part 16 a plurality ofspacer elements 26 are arranged on the side facing away from thebottom part 14, but no further plate for vertically delimiting the compartments indicated by the spacer elements. Such additional plate can, however, be provided optionally. - In the illustrated exemplary embodiment the
ceiling plate 34 has anoblong slot 36 asvertical passage opening 30, which extends from an outside up to about the center of theceiling plate 34. Shortly before the slightly enlargedcentral end 38 of the slot 36 arecess 40 extending transversely to the longitudinal direction of theslot 36 is formed in theceiling plate 34, which can be filled by a separate retaining part 42 (seeFIG. 3 ). On the opposite side of the slot end 38 an oblong spacer element 44 likewise extends transversely to the longitudinal direction of theslot 36. In the imaginary extension of theslot 36 this spacer element 44 includes adepression 46 on its free side facing away from theceiling plate 34. - Particularly preferably, the
bottom part 14, theceiling part 16 and thestruts 18 are fabricated of the same, gamma-sterilizable material, preferably polyethylene (PE). In principle, however, said parts also can be formed of another stable and fracture-proof material. - The
bottom part 14 and theceiling part 16 includeopposite fixtures 48 for eachstrut 18. When thestruts 18 are inserted into thefixtures 48 parallel to each other, a robust packaging frame is obtained, whose preferred use will be explained in more detail below. - Another optional part of the
packaging 10 is thefixture part 64 shown inFIG. 4 , of which several can be provided as well. Thefixture part 64 is of comb-like shape and hasseveral line receptacles 66 which are accessible viaconstricted passages 68. - The
container 12 to be packaged here is a pre-sterilized disposable bag with aflexible envelope 50. Thecontainer 12 contains an integrated stirrer which includesseveral stirring tools 52 and amagnetic body 54. Thestirring tools 52 and themagnetic body 54 are mounted on acentral shaft 56. In addition, several fluid lines (hoses) (not shown inFIGS. 1 and 2 ) are connected to thecontainer 12. According to the orientation in the condition of use as provided by the use of thecontainer 12 in a bioreactor, the majority of these hoses is provided at theupper portion 58 of thecontainer 12. To thelower portion 60 of the container 12 a central discharge hose is connected. At least at some of the hoses connecting pieces, fixing clamps or other hard or sharp-edged elements are disposed. - For packaging, the
container 12 initially is fixed with its upper end at thebottom part 14 of thepackaging 10, wherein themagnetic body 54 arranged at the upper shaft end is inserted into the central receptacle 32 of theupper base plate 24. The hoses mounted at theupper portion 58 of thecontainer 12 are guided through the respectively nearest passage opening 30 and received in thecompartment 28 underneath. The hose portions present in thecompartments 28 can be fixed in the rolled-up condition e.g. by clamps and/or be protected by wrapping or bagging. - Subsequently, the
struts 18 are inserted into thefixtures 48 of thebottom part 14, and thecontainer 12 is pulled upwards at the central discharge hose. For fixing thelower container portion 60 at theceiling part 16, the discharge hose is pulled to the center through theslot 36 in theceiling plate 34 and guided over thedepression 46 in the spacer element 44, so that the remaining part of the discharge hose comes to lie on theceiling plate 34 on the side facing away from theslot 36. This hose part, too, can be fixed in the rolled-up condition and be protected by further measures. - To ensure that the discharge hose takes a defined, kink-free course from the receiving
space 20 via the spacer element 44, the retainingpart 42 is inserted into therecess 40 after the discharge hose has been pulled up to theslot end 38. The retainingpart 42 prevents that the discharge hose can be shifted to the outside. (When unpacking thecontainer 12 later on, the retainingpart 42 is again removed from the recess 40). - Before, during or after fixing the
lower container portion 60 at theceiling part 16, theceiling part 16 is put onto thestruts 18. - According to the preferred transport condition as shown in
FIG. 2 , thecontainer 12 now is upside down with respect to its future condition of use, i.e. accommodated in thepackaging 10 with itsupper portion 58 at the bottom and itslower portion 60 at the top. - The distance between the
bottom part 14 and theceiling part 16 as defined by the length of thestruts 18 is chosen such that no or only a negligeable part of the fixedcontainer 12 can protrude laterally from the packaging frame between thestruts 18. - At an arbitrary time before the container finally is made ready for transport, the
separate fixture parts 64 still can be inserted, as shown inFIG. 5 . Thefixture parts 64 serve to fix hoses extending from theflexible envelope 50 of thecontainer 12. For this purpose, the hoses are pressed through thepassages 68 into the line receptacles 66 of thefixture parts 64 close to theenvelope 50. It thereby is achieved that those portions of the hoses which open into thecontainer 12 are fixed such that they more or less vertically extend from theenvelope 50 to the outside. This fixation ensures that hard or sharp-edged connectors, connecting pieces or other parts of the hoses are kept away from theflexible envelope 50, in order to prevent damages at theenvelope 50 itself, but also at the hoses and their connectors, connecting pieces etc. - To finally make the
container 12 ready for transport, the packaging frame also is covered with one or two plastic sacks or the like, which are welded closed or closed with adhesive tape, before the entire unit then is put into a shipping carton and secured with strapping tapes or packing tape. - The
packaging 10 as shown inFIGS. 1 to 5 is suitable for largeflexible containers 12 with a filling volume in the order of magnitude of 500 liters, 1,000 liters, 2,000 liters or more. -
FIGS. 6 and 7 show a second embodiment of thepackaging 10, which is suitable forsmaller containers 12 with a filling volume in the order of magnitude of 50 liters or 200 liters. The second embodiment substantially has the same construction as the first embodiment and only differs in the dimensions of the individual elements and in the concrete design of thebottom part 14 and theceiling part 16. In the second embodiment only asingle compartment 28 is formed in the bottom part, which however has a larger vertical height as compared to the first embodiment. A spacer element extending across theceiling plate 34 and a separate retaining element are not provided in theceiling part 16. Theceiling part 16 instead includes twosupport elements 62 which are lower than theouter spacer elements 26 of theceiling part 16. The rolled up discharge hose comes to lie on thesesupport elements 62. Thus, thesupport elements 62 here ensure that kinking of the discharge hose is avoided. - Both embodiments have in common that the
bottom parts 14 and theceiling parts 16 each have a rectangular, particularly preferably a square basic shape. This shape however is not absolutely necessary, just like the number ofstruts 18, i.e. depending on the requirement there can also be provided less (in particular three) or more than fourstruts 18, wherein an arrangement outdoors always is preferred. Thebottom part 14 and/or theceiling part 16 also can include several intermediate trays withpassage openings 30, so that thecompartments 28 for the hoses etc. also can be arranged one above the other. - Of course, one or
more fixture parts 64 can also be provided in the second embodiment. - In principle, features of the various embodiments can be combined with each other in a suitable way, in order to obtain further embodiments in accordance with the invention.
- The described embodiments each relate to a
packaging 10 for a special disposable bag which is provided for use in a bioreactor. The invention is, however, not limited to this application. Rather, thepackaging 10 according to the invention also can be used for other flexible containers or similar objects. -
-
- 10 packaging
- 12 container
- 14 bottom part
- 16 ceiling part
- 18 strut
- 20 receiving space
- 22 lower base plate
- 24 upper base plate
- 26 spacer element
- 28 compartment
- 30 passage opening
- 32 receptacle
- 34 ceiling plate
- 36 slot
- 38 slot end
- 40 recess
- 42 retaining part
- 44 spacer element
- 46 depression
- 48 fixture
- 50 envelope
- 52 stirring tool
- 54 magnetic body
- 56 shaft
- 58 upper container portion
- 60 lower container portion
- 62 support element
- 64 fixture part
- 66 line receptacle
- 68 passage
Claims (23)
1. A packaging for a flexible container, comprising
a bottom part for fixing a first portion of the container,
a ceiling part for fixing an opposite second portion of the container,
a receiving space which on a first side is defined by the bottom part and on an opposite second side is defined by the ceiling part, and
struts arranged between the bottom part and the ceiling part, which fix a defined distance between the bottom part and the ceiling part.
2. The packaging according to claim 1 , characterized in that the bottom part and/or the ceiling part is formed of foamed material.
3. The packaging according to claim 1 , characterized in that in the bottom part and/or in the ceiling part at least one compartment is formed, which is accessible from the receiving space via at least one passage opening.
4. The packaging according to claim 3 , characterized in that the bottom part and/or the ceiling part includes a lower plate and an upper plate, which are separated from each other by one or more spacer elements, wherein the at least one compartment is defined by the plates and the spacer element(s).
5. The packaging according to claim 4 , characterized in that the bottom part and/or the ceiling part has several passage openings which are each separately accessible from an outside of a plate of the bottom part and/or each separately from an outside of a plate of the ceiling part.
6. The packaging according to claim 3 , characterized in that the bottom part (14) and/or the ceiling part with the compartment formed therein is formed in one piece.
7. The packaging according to claim 3 , characterized in that the bottom part and/or the ceiling part with the compartment formed therein is composed of several parts and is designed as prefabricated assembly.
8. The packaging according to claim 4 , characterized in that a plate of the bottom part or of the ceiling part includes an oblong slot which extends from an outside of the plate to the inside.
9. The packaging according to claim 8 , characterized in that a spacer element arranged on the bottom part or the ceiling part transversely to the longitudinal direction of the slot includes a depression.
10. The packaging-according to claim 8 , characterized in that before an inner slot end a recess extending across the slot is formed in the plate, into which a separate retaining part can be inserted.
11. The packaging according to claim 1 , characterized in that both the bottom part and the ceiling part include opposite fixtures for the struts.
12. The packaging according to claim 1 , characterized in that the bottom part or the ceiling part includes a central receptacle for a magnetic body of a mixing tool arranged in the container.
13. The packaging according to claim 1 , characterized in that there is provided at least one separate fixture part for fixing hoses which extend from the flexible container.
14. The packaging according to claim 13 , characterized in that the fixture part includes at least one line receptacle-accessible via a passage, in which at least one hose portion can be fixed.
15. A transport unit with a flexible container, wherein the flexible container is a bag for use in a bioreactor, wherein the flexible container is received in a packaging according to claim 1 .
16. The transport unit according to claim 15 , characterized in that on an upper portion of the flexible container, with respect to the intended position of use of the flexible container, several hoses are mounted, which are guided through one or more passage openings of the bottom part or of the ceiling part into the compartment(s).
17. The transport unit according to claim 16 , characterized in that the one or more passage openings of the bottom part and/or of the ceiling part are each accessible separately from an outside of a plateof the bottom part and/or from an outside of a plate of the ceiling part.
18. The transport unit according to claim 17 , characterized in that each passage opening is connected with a separate compartment.
19. The transport unit according to claim 16 , characterized in that, with respect to its intended position of use, the flexible container is fixed at the bottom part with an upper portion and at the ceiling part with a lower portion.
20. The transport unit according to claim 16 , characterized in that on an upper portion of the container, with respect to the intended position of use of the flexible container, a central hose is mounted, which is guided through a passage opening of the ceiling part in the form of a slot into the at least one compartment.
21. The transport unit according to claim 20 , characterized in that the bottom part or the ceiling part includes at least two support elements on which the hose is deposited.
22. The transport unit according to claim 15 , characterized in that the flexible container includes a shaft with a magnetic body of a mixing tool supported on an end of the shaft, which magnetic body is inserted into a receptacle of the bottom part or of the ceiling part.
23. The transport unit according to claim 15 , characterized in that the arrangement and the length of the struts is adjusted to the expansion of the flexible container in a first direction between the bottom part and the ceiling part such that in the directions vertical to the first direction the flexible container does not or only slightly protrude between the struts.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DE102014101839.7 | 2014-02-13 | ||
DE102014101839.7A DE102014101839B4 (en) | 2014-02-13 | 2014-02-13 | Packaging for a flexible container and transport unit |
PCT/EP2014/076494 WO2015120927A1 (en) | 2014-02-13 | 2014-12-04 | Packaging for a flexible container, and a transportation unit |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/EP2014/076494 A-371-Of-International WO2015120927A1 (en) | 2014-02-13 | 2014-12-04 | Packaging for a flexible container, and a transportation unit |
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US16/438,815 Division US11939561B2 (en) | 2014-02-13 | 2019-06-12 | Process for assembling packaging for a flexible container |
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US20160333300A1 true US20160333300A1 (en) | 2016-11-17 |
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US16/438,815 Active 2038-07-19 US11939561B2 (en) | 2014-02-13 | 2019-06-12 | Process for assembling packaging for a flexible container |
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US16/438,815 Active 2038-07-19 US11939561B2 (en) | 2014-02-13 | 2019-06-12 | Process for assembling packaging for a flexible container |
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US (2) | US20160333300A1 (en) |
EP (2) | EP3153420B1 (en) |
CN (2) | CN107719950B (en) |
DE (1) | DE102014101839B4 (en) |
WO (1) | WO2015120927A1 (en) |
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US20160193576A1 (en) * | 2012-03-23 | 2016-07-07 | Life Technologies Corporation | Fluid mixing system with steady support |
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US10519409B2 (en) | 2014-12-31 | 2019-12-31 | Ge Healthcare Bio-Sciences Corp. | Shaft-mounted fluid transfer assembly for a disposable bioreactor |
US10836989B2 (en) | 2015-10-16 | 2020-11-17 | Global Life Sciences Solutions Usa Llc | Disposable container, mixing system and packaging |
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US11535421B2 (en) * | 2019-12-30 | 2022-12-27 | Global Life Sciences Solutions Usa Llc | System and method for packaging a bioprocessing bag and associated components, and packaging for a bioprocessing bag |
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Also Published As
Publication number | Publication date |
---|---|
CN106061861B (en) | 2019-05-28 |
CN107719950A (en) | 2018-02-23 |
DE102014101839A1 (en) | 2015-08-13 |
CN106061861A (en) | 2016-10-26 |
US11939561B2 (en) | 2024-03-26 |
DE102014101839A8 (en) | 2015-10-01 |
CN107719950B (en) | 2019-12-20 |
EP3105131A1 (en) | 2016-12-21 |
EP3153420A1 (en) | 2017-04-12 |
WO2015120927A1 (en) | 2015-08-20 |
EP3153420B1 (en) | 2018-09-05 |
DE102014101839B4 (en) | 2018-03-15 |
EP3105131B1 (en) | 2019-01-30 |
US20190292506A1 (en) | 2019-09-26 |
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