US20160194337A1

US20160194337A1 - Glycosidase inhibitors and uses thereof

Info

Publication number: US20160194337A1
Application number: US14/655,222
Authority: US
Inventors: Harold G. Selnick; Kun Liu; Ernest J. McEachern; Ramesh KAUL; Zhongyong Wei; Yaode Wang; Jiang Chang
Original assignee: Meadwestvaco Packaging Systems, Llc
Current assignee: Alectos Therapeutics Inc; Pharmaron Beijing Co Ltd; WestRock Packaging Systems LLC
Priority date: 2012-12-24
Filing date: 2013-12-08
Publication date: 2016-07-07
Also published as: WO2014105662A1; EP2935283B1; EP2935283A1; US9938299B2; WO2014100934A1; EP2935283A4

Abstract

A locking arrangement secures together first and second panels. The arrangement includes locking tabs (54, 56, 58) projecting from an end edge (64) of the first panel (12) and locking slits (50 a, 50 b, 50 c) in the second panel (28). Each locking slit is provided for receiving a respective one of the locking tabs. The locking tabs and the locking slits are engageable by relative sliding movement with each other. At least one of the locking tabs and locking slits is configured to secure the first and second panels in a first overlapping position while at least another one of the locking tabs and locking slits is configured to secure the first and second panels in a second overlapping position.

Description

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. Provisional Patent Application No. 61/735,176 filed Dec. 10, 2012, which is incorporated herein by reference in its entirety.

FIELD OF THE INVENTION

The present invention relates to a locking arrangement for a locking two panels of a carton together to a carton and a blank and a method of securing a carton blank about a product, more specifically, but not exclusively to a locking arrangement having multiple locking positions.

BACKGROUND OF THE INVENTION

In the field of packaging it is often required to provide consumers with a package comprising multiple primary product containers, such multi-packs are desirable for shipping and distribution and for display of promotional information. For cost and environmental considerations, such cartons or carriers need to be formed from as little material as possible and cause as little wastage in the materials from which they are formed as possible. Another consideration is the strength of the packaging and its suitability for holding and transporting large weights of articles.
It is desirable to lock a pair of panels forming a package about the primary product containers; in particular it is desirable to ensure a tight fit of the carton, such as but not limited to a wraparound style carton, about the primary product container or containers.

SUMMARY OF INVENTION

The present invention seeks to overcome or at least mitigate the problems of the prior art.
According to a first aspect of the present invention there is provided a locking arrangement for securing together a pair of panels, the arrangement comprising locking tabs projecting from an end edge of a first panel of the pair of panels and locking slits provided adjacent an end edge of the second panel of the pair of panels, wherein a locking slit is provided for receiving each of the respective locking tabs, the locking tabs and the locking slits being engageable by relative sliding movement therebetween, wherein at least one of the locking tabs or locking slits is configured to secure the pair of panels in a first overlapping position and at least one of the other the locking tabs or locking slits is configured to secure the pair of panels in a second overlapping position.
Optionally, the locking arrangement comprises at least one further locking tab or locking slit configured to secure the pair of panels in at least one further position having another degree of overlap.
Optionally, the second degree of overlap when the first and second panels are disposed in the second position is greater than the first degree of overlap when the first and second panels are disposed in the first position.
Optionally, at least one of locking tabs shares a common cutline with at least one adjacent locking tab.
Optionally, the locking arrangement comprises a first group of locking tabs.
Preferably, each of the locking tabs in the first group sharing a common cutline with at least one adjacent locking tab in the first group.
Optionally, the locking arrangement comprises a second group of locking tabs.
Preferably, each of the locking tabs in the second group sharing a common cutline with at least one adjacent locking tab in the second group.
Optionally, the locking tabs in the first group of locking tabs are spaced apart from the locking tabs in the second group of locking tabs.
Alternatively, one of the locking tabs in the first group of locking tabs is spaced apart from one of the locking tabs in the second group of locking tabs.
Optionally, the spacing between a locking tab in the first group of locking tabs and an adjacent locking tab in the second group of locking tabs is greater than the spacing between a pair of adjacent locking tabs forming part of either of the first or second groups.
In some embodiments an aperture is disposed between a pair or adjacent locking tabs which share a common cutline, the aperture being struck in part from the first panel and defining in part a recess in the edge of the first panel such that the edge of the first panel defined by the recess is inset from a leading edge of the first panel.
Preferably, the at least a first one of the locking tabs comprises an engaging edge spaced from the free end edge of the first panel by a first distance.
Preferably, the at least a second one of the locking tabs comprises an engaging edge spaced from the free end edge of the first panel by a second distance, the second distance being greater than the first distance.
Optionally, the engaging edge is a trailing edge of the locking tab.
Optionally, the at least a first one of the locking slits is spaced apart from the end edge of the second panel by a first distance.
Optionally, the at least a second one of the locking slits is spaced apart from the end edge of the second panel by a second distance, the second distance being greater than the first distance.
Optionally, the at least a first one of the locking slits comprises an abutment edge spaced from the free end edge of the second panel by a first distance.
Optionally, the at least a second one of the locking slots comprises an abutment edge spaced from the free end edge of the second panel by a second distance, the second distance being greater than the first distance.
Optionally, the abutment edge is a defined by the locking slit.
Optionally, the locking tabs are each coupled to the first panel by a fold line for allowing the locking tabs to fold with respect to the first panel.
Optionally, at least one first fold line coupling at least one first locking tab is disposed at first distance with respect to an end edge of the first panel and at least one second fold line coupling at least one second locking tab is disposed at second distance with respect to an end edge of the first panel, the second distance being greater than the first distance.
Preferably, the at least a first one of the locking tabs projects from the end edge of the first panel by a first dimension.
Optionally, the at least a second one of the locking tabs projects from the end edge of the first panel by a second dimension, the second dimension being greater than the first dimension.
According to a second aspect of the present invention there is provided a blank for forming a carton comprising a plurality of panels for forming a top panel base panel and opposing side walls interconnecting the top and base panels, wherein one of the plurality of panels is a composite panel comprising a first panel and a second panel, the blank comprising a locking arrangement, the arrangement comprising locking tabs projecting from an end edge of the first panel and locking slits provided adjacent an end edge of the second panel, wherein a locking slit is provided for receiving each of the respective locking tabs, the locking tabs and the locking slits being engageable by relative sliding movement therebetween, wherein at least one of the locking tabs or locking slits is configured to secure the first and second panels in a first overlapping position and at least one of the other the locking tabs or locking slits is configured to secure the first and second panels in a second overlapping position.
According to a third aspect of the present invention there is provided a carton comprising a plurality of panels including a top panel, a base panel and opposing side walls interconnecting the top and base panels, wherein one of the plurality of panels is a composite panel comprising a first panel and a second panel, the carton comprising a locking arrangement, the arrangement comprising locking tabs projecting from an end edge of the first panel and locking slits provided adjacent an end edge of the second panel, wherein a locking slit is provided for receiving each of the respective locking tabs, the locking tabs and the locking slits being engageable by relative sliding movement therebetween, wherein at least one of the locking tabs or locking slits is configured to secure the first and second panels in a first overlapping position and at least one of the other the locking tabs or locking slits is configured to secure the first and second panels in a second overlapping position.
Optionally, the degree of overlap when the first and second panels are disposed in the second position is greater than the degree of overlap when the first and second panels are disposed in the first position, such that the carton has a smaller internal volume in the second position.
According to a fourth aspect of the present invention there is provided a locking arrangement for securing together a pair of panels, the pair of panels comprising a first panel and a second panel, the arrangement comprising at least one first locking tab projecting from an end edge of the first panel, at least one second locking tab projecting from an end edge of the first panel and at least one first locking slit provided adjacent an end edge of the second panel for receiving the at least one first locking tab and at least one second locking slit provided adjacent an end edge of the second panel for receiving the at least one first locking tab, wherein the at least one first locking tab and the at least one first locking slit are configured to secure the first and second panels in a first overlapping position and at least one second locking tab and at least one second locking slit are configured to secure the first and second panels in a second overlapping position.
According to a fifth aspect of the present invention there is provided a method for securing together a pair of panels, the pair of panels comprising a first panel and a second panel and including locking arrangement comprising at least one first locking tab projecting from an end edge of the first panel, at least one second locking tab projecting from an end edge of the first panel and at least one first locking slit provided adjacent an end edge of the second panel for receiving the at least one first locking tab and at least one second locking slit provided adjacent an end edge of the second panel for receiving the at least one first locking tab, wherein the at least one first locking tab and the at least one first locking slit are configured to secure the first and second panels in a first overlapping position and at least one second locking tab and at least one second locking slit are configured to secure the first and second panels in a second overlapping position, the method comprising;

- determining whether to secure the pair of panels in the first or second overlapping position,
- sliding the pair of panels with respect to one another so as to engage the at least one first locking tab with the at least one first locking slit so as to engage the pair of panels in the first overlapping position, and
- when securing the pair of panels in the second overlapping position, further sliding the pair of panels with respect to one another so as to engage the at least one second locking tab with the at least one second locking slit so as to engage the pair of panels in the second overlapping position.

According to a sixth aspect of the present invention there is provided a carton for packaging one or more articles, the carton comprising a plurality of panels including a top panel, a base panel and opposing side walls interconnecting the top and base panels, wherein one of the plurality of panels is a composite panel comprising a first panel and a second panel, the carton comprising a locking arrangement, the arrangement comprising locking tabs projecting from an end edge of the first panel and locking slits provided adjacent an end edge of the second panel, wherein a locking slit is provided for receiving each of the respective locking tabs, the locking tabs and the locking slits being engageable by relative sliding movement therebetween, wherein a portion of at least one of the locking tabs shares a common cutline or weakened line of severance with a portion of at least one adjacent locking tab when the carton is in a blank form.
Preferably, the portion of the at least one of the locking tabs is complementary in shape to the portion of the at least one adjacent locking tab. This gives the at least one of the locking tabs the appearance of being struck from, or interrupted by, a portion of the at least one adjacent locking tab.
Within the scope of this application it is envisaged that the various aspects, embodiments, examples, features and alternatives set out in the preceding paragraphs, in the claims and/or in the following description and drawings may be taken independently or in any combination thereof. For example, features described in connection with one embodiment are applicable to all embodiments unless there is incompatibility of features.

BRIEF DESCRIPTION OF THE DRAWINGS

Exemplary embodiments of the invention will now be described with reference to the accompanying drawings, in which:

FIG. 1 is a plan view from above of a blank for forming a carton according to a first embodiment of the invention;

FIG. 2 is a perspective view from above of a portion of a locking mechanism according to the first embodiment of the invention in a stage of assembly;

FIG. 3 is a perspective view from above of a portion of a locking mechanism according to the first embodiment of the invention in a later stage of assembly;

FIG. 4A is a perspective view of a carton formed from the blank of FIG. 1 in which a pair of panels is locked in a first overlapping position;

FIG. 4B is a perspective view of a carton formed from the blank of FIG. 1 in which a pair of panels is locked in a second overlapping position;

FIG. 5 is a plan view from above of a blank for forming a carton according to a second embodiment of the invention;

FIG. 6 is a plan view from above of a blank for forming a carton according to a third embodiment of the invention;

FIG. 7 is a perspective view from above of a portion of a locking mechanism according to the third embodiment of the invention in a stage of assembly;

FIG. 8 is a perspective view from above of a portion of a locking mechanism according to the third embodiment of the invention in an assembled condition;

FIG. 9 a view from below of a portion of a locking mechanism according to the third embodiment of the invention in an assembled condition;

FIG. 10 is a plan view from above of a blank for forming a carton according to a fourth embodiment of the invention;

FIG. 11 is a fragmentary plan view of a blank for forming a carton according to a fifth embodiment of the invention; and

FIG. 12 is another fragmentary plan view of the blank of FIG. 11, showing a portion of the blank different from a portion shown by FIG. 11.

DETAILED DESCRIPTION OF EXEMPLARY EMBODIMENTS OF THE PRESENT INVENTION

Detailed descriptions of specific embodiments of the package, blanks and cartons are disclosed herein. It will be understood that the disclosed embodiments are merely examples of the way in which certain aspects of the invention can be implemented and do not represent an exhaustive list of all of the ways the invention may be embodied. As used herein, the word “exemplary” is used expansively to refer to embodiments that serve as illustrations, specimens, models, or patterns. Indeed, it will be understood that the packages, blanks and cartons described herein may be embodied in various and alternative forms. The figures are not necessarily to scale and some features may be exaggerated or minimised to show details of particular components.
Well-known components, materials or methods are not necessarily described in great detail in order to avoid obscuring the present disclosure. Any specific structural and functional details disclosed herein are not to be interpreted as limiting, but merely as a basis for the claims and as a representative basis for teaching one skilled in the art to variously employ the invention.
Referring to FIG. 1 there is shown a plan view from above of a blank 10 capable of forming a carton for packaging one or more primary products, such as, but not limited to, bottles or cans, hereinafter referred to as articles.
In the embodiments detailed herein, the terms carton and carrier refer, for the non-limiting purpose of illustrating the various features of the invention, to a container for engaging, carrying, and/or dispensing articles, such as bottles. However, it is contemplated that the teachings of the invention can be applied to various containers, which may or may not be tapered and/or cylindrical. Other exemplary articles include bottles (for example metallic, glass or plastics bottles), cans (for example aluminium cans), tins, pouches, packets and the like.
The blank is formed from a sheet of suitable substrate. It is to be understood that, as used herein, the term “suitable substrate” includes all manner of foldable sheet material such as paperboard, corrugated board, cardboard, plastic, combinations thereof, and the like. It should be recognized that one or other numbers of blanks may be employed, for example, to provide the carrier structure described in more detail below.
In the exemplary embodiment, the blank is configured to form a carton or carrier for packaging an exemplary arrangement of exemplary articles. For example, the arrangement is a matrix including rows and columns such as a 2×2 arrangement of articles. The blank can be alternatively configured to form a carrier for packaging other articles and/or different arrangements of articles.
Blank 10 comprises a linear series of panels 12, 14, 16, 18, 20, 22, 24, 26, 28, 28 a hinged one to the next by a respective fold line 13, 15, 17, 19, 21, 23, 25, 27. Blank 10 comprises a pair of end closure structures 30 a, 30 b which partially close ends of the carton assembled form the blank 10. In other embodiments it is envisaged that the end closure structures 30 a, 30 b may fully close the ends of the carton.
The blank 10 comprises a first base panel 12 hinged to a first bevelled panel 14 by a fold line 13. First bevel panel 14 is hinged to a first lower side panel 16 by a fold line 15. First lower side panel 16 is hinged to a first upper side panel 18 by a fold line 17. First upper side panel 18 is hinged to a top panel 20 by a fold line 19. Top panel 21 is hinged to a second upper side panel 22 by a fold line 21. Second upper side panel 22 is hinged to a second lower side panel 24 by a fold line 23. Second lower side panel 24 is hinged to a second bevel panel 26 by a fold line 25. Second bevel panel 26 is hinged to a second base panel 28 by a fold line 27. Second base panel 28 is hinged to a hinge panel 28 a by a fold line 52.
First end closure structure 30 a comprises a first top end closure panel 32 a hinged to the top panel 20 by a fold line 31 a. A first web panel 34 a is hinged to first top end closure panel 32 a along a first side edge, by a fold line 33 a. A second web panel 36 a is hinged to first top end closure panel 32 a along a second side edge, by a fold line 35 a. A first gusset panel 38 a interconnects first web panel 34 a to a first anchor panel 42 a, first gusset panel 38 a is hinged to first web panel 34 a by a fold line 39 a and to first anchor panel 42 a by a fold line 43 a. A second gusset panel 40 a interconnects second web panel 36 a to a second anchor panel 44 a, second gusset panel 40 a is hinged to second web panel 36 a by a fold line 37 a and to second anchor panel 44 a by a fold line 41 a. First anchor panel 42 a is hinged to first upper side panel 18 by a fold line 7 a. Second anchor panel 44 a is hinged to second upper side panel 22 by a fold line 9 a. An aperture A separates the first gusset panel 38 a from the first upper side panel 18 and the top panel 20. An aperture A separates the second gusset panel 40 a from the second upper side panel 22 and the top panel 20.
Second end closure structure 30 b comprises a second top end closure panel 32 b hinged to the top panel 20 by a fold line 31 b. A third web panel 34 b is hinged to second top end closure panel 32 b along a first side edge, by a fold line 33 b. A fourth web panel 36 b is hinged to second top end closure panel 32 b along a second side edge, by a fold line 35 b. A third gusset panel 38 b interconnects third web panel 34 b to a third anchor panel 42, third gusset panel 38 b is hinged to third web panel 34 b by a fold line 39 b and to third anchor panel 42 b by a fold line 43 b. A fourth gusset panel 40 b interconnects fourth web panel 36 b to a fourth anchor panel 44 b, fourth gusset panel 40 b is hinged to fourth web panel 36 b by a fold line 37 b and to fourth anchor panel 44 b by a fold line 41 b. Third anchor panel 42 b is hinged to first upper side panel 18 by a fold line 7 b. Fourth anchor panel 44 a is hinged to second upper side panel 22 by a fold line 9 b. An aperture A separates the third gusset panel 38 b from the first upper side panel 18 and the top panel 20. An aperture A separates the fourth gusset panel 40 b from the second upper side panel 22 and the top panel 20.
Blank 10 comprises a means for locking the first and second base panels 12, 28 together. The locking mechanism 70 comprises a male M portion and a female portion F forming a first part of a complimentary locking mechanism 70 and second part of a complimentary locking mechanism 70.
Referring now to FIGS. 1 to 3 the first part M of the complimentary locking mechanism 70 comprises a male locking tab 54/54 a, 56/56 a, 58/58 a which is coupled to the first base panel 12 along fold lines 55, 57, 59 respectively. The male locking tabs 54/54 a, 56/56 a, 58/58 a project outwardly, in the plane of the first base panel 12, from the end edge 16 thereof. The male locking tab 54/54 a, 56/56 a, 58/58 a comprises a main portion 54, 56, 58 and an integral anchoring tab 54 a, 56 a, 58 a which is hinged to one side edge of the main portion 54, 56, 58 along a fold line 61, 63, 65 respectively. The fold lines 61, 63, 65 are substantially perpendicular to the end edge 16 of first base panel 12. The trailing edge 66 of the anchoring tab is spaced from end edge 16 and, in use, provides a locking edge for cooperation with an abutment edge defined by a locking slit in second base panel 28. In alternative embodiments the main portion 54, 56, 58 may formed to include a nose which projects beyond the foldable anchoring tab 54 a, 56 a, 58 a to lead insertion of the male locking tab 54/54 a, 56/56 a, 58/58 a in a locking slit of second base panel 28.
Second base panel 28 includes a locking slit 50 a, 50 b, 50 c in the form of a shallow “Y” which is struck from second base panel 28 along a fold line 52 extending parallel to the end edge 11 of second base panel 28. Thus, second base panel 28 has a foldable front edge strip or hinge panel 28 a. The slit 50 a, 50 b, 50 c is formed by a continuous cut line comprising a first part extending along hinge panel 28 a towards the end edge of the second base panel 28 at an acute angle with respect to fold line 52; a return part extending back to meet fold line 52 at an acute angle with respect thereto; and an leg part extending substantially perpendicularly to fold line 52 from the vertex between the first part and the return part. When front edge strip 32 is folded out of the plane of the blank the slit 50 a, 50 b, 50 c is opened and the first and return parts define a guide projection 49 a extending outwardly from fold line 52.
The upright leg portion of the “Y” shaped cut allows the material forming the hinged panel 28 a above the aperture created by folding the hinge panel 28 a to flex or bend when inserting the male locking tabs 54/54 a, 56/56 a, 58/58 a.
In order to lock together first and second base panels 12 and 28, first the anchoring tabs 54 a, 56 a, 58 a are folded 180 degrees about fold lines 61, 63, 65 respectively into face contacting relationship with the underside of the respective main portion 54, 56, 58. Also, the hinge panel 28 a is folded about fold line 52 out of the plane of the blank (FIG. 2) to open the slits 50 a, 50 b, 50 c. Once the anchoring tabs 54 a, 56 a, 58 a have been folded thus, the maximum transverse dimension (corresponding to the maximum width of the main portions 54, 56, 58) from fold line 61, 63, 65 to the opposite edge of the respective male locking tab 54/54 a, 56/56 a, 58/58 a is sized so that the male locking tab 54/54 a, 56/56 a, 58/58 a can be slidingly engaged in a respective one of the locking slits 50 a, 50 b, 50 c. The locking tabs 54/54 a, 56/56 a, 58/58 a may be an interference fit in the locking slits 50 a, 50 b, 50 c. Hence, locking tabs 54/54 a, 56/56 a, 58/58 a can be inserted into the locking slits 50 a, 50 b, 50 c until the trailing edge 66 of the anchoring tabs 54 a, 56 a, 58 a has moved past, that is to say, cleared the abutment edge 68 of the locking slits 50 a, 50 b, 50 c. The natural resilience of the paperboard material then allows the folded anchoring tabs 54 a, 56 a, 58 a automatically to spring back into a more upright position unless otherwise constrained whereby the trailing edge 66 at or adjacent fold line 61, 63, 65 is brought into a position in which it will abut against the abutment edge 68 when tension is applied to the first and second base panels 12, 28 in opposition to the locking direction i.e. in a direction tending to move the panels apart. Thus, the abutting engagement between edge 66 and edge 68 of the locking slits 50 a, 50 b, 50 c maintains the first and second base panels 12, 28 locked together. The projection 49 a aids in the alignment of the locking tabs 54/54 a, 56/56 a, 58/58 a into the slits 50 a, 50 b, 50 c during locking.
In some circumstances, such as when the panels 12, 28 are base panels of a carton and packed articles are disposed upon the interlocked panels 12, 28, both the hinge panel 28 a of panel 28 and the anchoring tabs 54 a, 56 a, 58 a may be flat, that is parallel to the plane of the panels 12, 28. Nevertheless, the abutment between trailing edge 66 at or adjacent fold lines 61, 63, 65 and abutment edge 68 maintains the panels interlocked. Moreover, the double-ply thickness of material provided by both the main portions 54, 56, 58 and anchoring tabs 54 a, 56 a, 58 a is sufficient to prevent withdrawal of the locking tab 54/54 a, 56/56 a, 58/58 a from the locking slits 50 a, 50 b, 50 c. It will be appreciated that in this locking configuration, the trailing edge 66 lies substantially parallel to the abutment edge 68 to enhance the engagement between the panels.
Central locking tab 56/56 a which is disposed between locking tabs 54/54 a, 58/58 a is configured to provide a tighter locking position than the outer locking tabs 54/54 a, 58/58 a. In which the degree of overlap of the first base panel 12 with the second base panel 28 is greater than which is achieved by engaging the outer locking tabs 54/54 a, 58/58 a. This is achieved by offsetting the abutment edge 66 of the locking tab 56/56 a from the abutment edges of the outer locking tabs 54/54 a, 58/58 a. The abutment edge 66 of the locking tab 56/56 a is disposed in closer proximity to the edge 64 of first base panel 12 than the abutment edges 66 of the outer locking tabs 54/54 a, 58/58 a; the abutment edge 66 of the locking tab 56/56 a is offset by a distance O from the abutment edges 66 of the outer locking tabs 54/54 a, 58/58 a. The outer locking tabs 54/54 a, 58/58 a extends from the edge 64 of first base panel 12 by a first dimension L1. The central locking tab 56/56 a extends from the edge 64 of first base panel 12 by a second dimension L2. The first dimension L1 is greater than the second dimension L2. The staggered or offset arrangement of the leading edges of the locking tabs 54/54 a, 56/56 a, 58/58 a provides that only the outer locking tabs 54/54 a, 58/58 a need to be aligned simultaneously, thereby simplifying assembly of the carton 90. Alignment of the central locking tab 56/56 a with its respective locking slit 50 b is aided or facilitated by the offset arrangement of the leading edges of the locking tabs 54/54 a, 56/56 a, 58/58 a, since the central locking tab 56/56 a is constrained once the outer locking tabs 54/54 a, 56/56 a, 58/58 a have been inserted into their respective locking slits 50 a, 50 c.
In the illustrated embodiment the male locking tabs 54/54 a, 56/56 a, 58/58 a are coupled to the first base panel 12 by a respective fold line 55, 57, 59. In alternative embodiments the fold lines 55, 57, 59 may be omitted.
Optionally, the fold line 57 coupling the locking tab 56/56 a to the first base panel 12 is offset from the fold lines 55, 59 coupling the outer locking tabs 54/54 a, 58/58 a to the first base panel 12. The fold line 57 is disposed in closer proximity to, preferably co-linear with, the edge 64 of first base panel 12 than the fold lines 55, 59 of the outer locking tabs 54/54 a, 58/58 a. The outer locking tabs 54/54 a, 58/58 a are coupled to a small projection extending from the first base panel 12 in this way the leading edge of the outer locking tabs 54/54 a, 58/58 a is disposed further from the free end edge of the first base panel 12 than the leading edge of the central locking tab 56/56 a, the outer locking tabs 54/54 a, 58/58 a are thereby brought into contact with the second base panel 228 and hinge panel 228 a before the central locking tab 56/56 a.
In this way when bringing the first base panel 212 and second base panel 228 together the outer locking tabs 54/54 a, 58/58 a may contact the hinge panel 228 a and slide over the hinge panel 228 a until the outer locking tabs 54/54 a, 58/58 a contact the projection 49 a to align the outer locking tabs 54/54 a, 58/58 a with the outer locking slits 50 a, 50 c.
Turning to the construction of the carton 90 as illustrated in FIGS. 4A and 4B, it is envisaged that the carton 90 can be formed by a series of sequential folding operations in a straight line machine so that the carton 90 is not required to be rotated or inverted to complete its construction. The folding process is not limited to that described below and may be altered according to particular manufacturing requirements.
The carton 90 is formed by wrapping the blank 110 about one or more articles (not shown). The top panel 20 is disposed over a group of articles, the top end closure panels 32 a, 32 b are folded about the ends of the article group by folding the anchor panel 42 a, 42 b, 44 a, 44 b abut fold line 43 a, 43 b, 41 a, 41 b respectively so as to be substantially in face contacting relationship with the first or second upper side panel to which each anchor panel 42 a, 42 b, 44 a, 44 b is hinged. This automatically folds the top end closure panels 32 a, 32 b and web panels 34 a, 34 b, 36 a, 36 b about the group of articles. The first and second upper side panels 18, 22 are folded (along with the first and second lower side panels 16, 24, first and second bevel panels 14, 26 and first and second base panel 12, 28) about fold lines 19, 21 respectively to place the anchor panels 42 a, 42 b, 44 a, 44 b between the group of article and the respective first or second upper side panel 18, 22; thus anchoring the top end closure panels 32 a, 32 b in position.
The first and second bevel panels 14, 26 when provided are folded about fold line 15, 25 respectively about the lower portion of the article group. The first and second base panels 12, 28 are folded about the fold lines 13, 28 respectively so as to be disposed below the group of articles. The complimentary locking mechanisms 70 are employed as described above to lock the first base panel 12 and second panel 28 together. The first and second base panels 12, 28 may be locked in either a first overlapping position, as shown in FIG. 4A, in which the outer locking tabs 54/54 a, 58/58 a are fully engaged or fully inserted with the locking slits 50 a, 50 c or a second overlapping position, as shown in FIG. 4B, in which all locking tabs 54/54 a, 56/56 a, 58/58 a are fully engaged or fully inserted with the locking slits 50 a, 50 b, 50 c depending upon the dimensions of the article group being packaged and/or the tightness of the carton about the group of articles required.
In the first position as illustrated in FIG. 4A the central locking tab 56/56 a is maintained in a folded condition, such that the anchor tab 56 a is substantially in face contacting relationship with main portion 56 of the central locking tab 56/56 a. The anchor tabs 54 a, 58 a of each of the endmost or outer locking tabs 54/54 a, 58/58 a have passed through the respective locking slit 50 a, 50 c and have partially unfolded, due to the inherent resilience of the material of the blank 10, such the anchor tabs 54 a, 58 a are in locking engagement with the hinge panel 28 a.
The carton 90 in the first position or assembly configuration, as shown in FIG. 4A, comprises a composite base panel 12/28 formed from the first and second base panels 12, 28, the composite base panel 12/28 has width dimension W1 defined between the first bevel panel 14 and the second bevel panel 26. The carton 90 in the second position or assembly configuration, as shown in FIG. 4B, comprises a composite base panel 12/28 formed from the first and second base panels 12, 28, the composite base panel 12/28 has width dimension W2 defined between the first bevel panel 14 and the second bevel panel 26. The width dimension W2 is less than the width dimension W1 such that the first second bevel panel 14 is disposed closer to the second bevel panel 26 in the second position than in the first position.
In the second position the degree of overlap of the first base panel 12 with the second base panel 28 is greater than the degree of overlap of the first base panel 12 with the second base panel 28 when disposed in the first position.
In the second position the anchor tab 56 a of the central locking tab 56/56 a in addition to the anchor tabs 54 a, 58 a of each of the endmost or outer locking tabs 54/54 a, 58/58 a have passed through the respective locking slit 50 a, 50 b, 50 c and have partially unfolded, due to the inherent resilience of the material of the blank 10, such the anchor tabs 54 a, 56 a, 58 a are in locking engagement with the hinge panel 28 a.
In the first position trailing edge 66 of each of the outer locking tabs 54/54 a, 58/58 a is in abutment with abutment edge 68 of the hinge panel 28 a. The hinge panel 28 a prevents the anchor tab 56 a from unfolding since the hinge panel 28 a is disposed over the anchor tab 56 a of the locking tab 56/56 a.
In the second position trailing edge 66 of the central locking tab 56/56 a is in abutment with abutment edge 68 of the hinge panel 28 a. The anchor tabs 54 a, 56 a, 58 a are all unfolded. The trailing edge 66 of each of the outer locking tabs 54/54 a, 58/58 a may be spaced apart from the abutment edge 68 of the hinge panel 28 a. The outer locking tabs 54/54 a, 58/58 a each serve to stabilise the interlocking arrangement of the first and second base panels 12, 28.
Referring now to FIGS. 5 to 11, there is shown alternative embodiments of the present invention. In the second, third, fourth and fifth illustrated embodiments, like numerals have, where possible, been used to denote like parts, albeit with the addition of the prefix “100”, “200”, “300” or “400” to indicate that these features belong to the second, third, fourth or fifth embodiment. The alternative embodiments share many common features with the first embodiment and therefore only the differences from the embodiment illustrated in FIGS. 1 to 4 will be described in any greater detail.
FIG. 5 illustrates a blank 110 for forming a carton according to a second embodiment, blank 110 comprises four apertures A1 struck at least in part from the top panel 120. Two of the apertures interrupt the fold line 121 between the top panel 120 and the second upper side panel 122. Apertures A1 may each receive a portion of a respective article such as a neck portion or upper portion.
The blank 110 comprises four complimentary locking mechanisms and include four male locking tabs 154, 156, 158, 160 and four locking slits 150 a, 150 b, 150 c, 150 d. The four male locking tabs 154, 156, 158, 160 are arranged in a linear series so as to be in close proximity with at least one adjacent male locking tabs 154, 156, 158, 160; The anchor tab of locking tab 154 is shaped to be complimentary to an edge portion of the main portion of the adjacent locking tab 156, anchor tab of locking tab 156 is shaped to be complimentary to an edge portion of the main portion of the adjacent locking tab 158, anchor tab of locking tab 158 is shaped to be complimentary to an edge portion of the main portion of the adjacent locking tab 160. It will be appreciated that each male locking tabs 154, 156, 158, 160 shares a common cutline or weakened line of severance with at least one adjacent male locking tabs 154, 156, 158, 160.
The locking slits 150 a, 150 b, 150 c, 150 d are arranged in a linear series and interrupt the fold line 152 coupling the hinge panel 128 a to the second base panel 28. The central pair of locking slits 150 b, 150 c is disposed in closer proximity to the fold line 127 between the second base panel 128 and the second bevel panel 126 than the locking slits 150 a, 150 d at each end of the linear series. Each of the central pair of locking slits 150 b, 150 c is offset by a distance O with respect to the locking slits 150 a, 150 d at each end of the linear series. The central locking slits 150 b, 150 c are disposed at a first distance x from the free end edge of the second base panel 128 and the endmost locking slits 150 a, 150 d are disposed at a second distance y from the free end edge of the second base panel 128; the second distance y is less than the first distance x.
Blank 110 comprises three apertures 155, 157, 159; first aperture 155 is disposed between first locking tab 154 and second locking tab 156, second aperture 157 is disposed between second locking tab 156 and third locking tab 158, and third aperture 159 is disposed between third locking tab 158 and fourth locking tab 160. Each of the first, second and third apertures 155, 157, 159 is struck in part from the first base panel 112 such that a portion of the edge of the first base panel defined by each of the first, second and third apertures 155, 157, 159 is offset from a leading edge of the first base panel defined by fold lines hingedly connecting the male locking tabs 154, 156, 158, 160 to the first base panel 112.
When the hinge panel 128 a is folded about the fold line 152 the offset O between the central pair of locking slits and the endmost locking slits places the endmost locking slits 150 a, 150 d in closer proximity to the fold line 127 between the second base panel 128 and the second bevel panel 126 than the central pair of locking slits 150 b, 150 c.
The blank 110 can be formed into a carton which comprises two locking positions:

- A first locking position in which the first and second base panels 112, 128 are disposed in overlapping relationship, the region of overlap defining a first overlapping area. In the first locking or overlapping position the endmost locking tabs 154, 160 are each in locking engagement with respective endmost locking slit 150 a, 150 d in which they are received. The central locking tabs 156, 158 are not fully inserted into the respective locking slit 150 b, 150 c such that the anchor tab of each of the central locking tabs 156, 158 is maintained in a folded relationship, with respect to the respective main portion of the central locking tabs 156, 158 to which it is hinged, by the hinge panel 128 a.
- A second locking position in which all the locking tabs 154, 156, 158, 160 are fully inserted or engaged with the respective locking slit 150 a, 150 b, 150 c, 150 d in which they are received, the central locking tabs 156, 158 are each in locking engagement (the trailing edge of the anchor tab is in abutment with the abutment edge of the locking slit 150 b, 150 c) with the central locking slits 150 b, 150 c and the trailing edge of the anchor tab of each of the endmost pair of locking tabs 154, 160 is spaced apart from the abutment edge of the respective locking slit 150 a, 150 d.

In an alternative embodiment the central pair of locking tabs 156, 158 are spaced apart from one another, a first endmost locking tab 154 being in contact with a first one of the central locking tabs 156, and a second endmost locking tab 160 being in contact with a second one of the central locking tabs 158. In this way the locking tabs 154, 156, 158, 160 are arranged in two distinct groups, wherein the groups are spaced apart from one another but the locking tabs 154, 156, 158, 160 in each group are substantially in contact with one another when formed in the blank 110. It is envisaged that the locking slits 150 a, 150 b, 150 c, 150 d will be arranged so as to receive a respective one of the locking tabs 154, 156, 158, 160. In such arrangements it is envisaged that each locking tab or locking slit in a group may lock the first and second base panels 112, 128 in the same locking position or in different locking positions. In this way a first group of locking tabs and locking slits may lock the first and second base panels 112, 128 in a first position and a second group of locking tabs and locking slits may lock the first and second base panels 112, 128 in a second position.
Turning now to FIGS. 6 to 10 there is shown a blank 210 for forming a carton according to a third embodiment. Blank 210 comprises an alternative locking mechanism, which includes a male locking member 280 a, 280 b, 280 c
Blank 210 comprises three complementary locking devices. Blank 210 comprises a first part F of a complementary locking device and a second part M of a complementary locking device.
First part F comprises a flap 228 a hingedly connected to a first panel 228 by fold line 252, first panel 228 forms a second base panel of a carton.
Fold line 252 is interrupted by a cut lines or weakened lines of severance 250 a, 250 b, 250 c. Cut lines 250 a, 250 b, 250 c are at least partially offset from fold line 252. In the illustrated embodiment the cut lines 250 a, 250 b, 250 c are disposed or located within flap 228 a, such that each defines in part a first projection 289 a, 289 b, 289 c, which first projections 289 a, 289 b, 289 c are integrally formed with the first panel 228.
Cut lines 250 a, 250 b, 250 c are stepped or tiered in shape; a central linear portion defines a leading edge of first projections 289 a, 289 b, 289 c. First linear section defines a first tier. A second tier is disposed on either side of the first tier. Second tier is defined by outer portions 287 a, 288 a of cutline 250 a and is disposed closer to fold line 252 than the first tier. The outer portions 287 a, 288 a defining the second tier are preferably disposed at an angle with respect to the fold line 252 and with respect to the first tier; the outer edges of the outer portions 287 a, 288 a of cutline 250 a defining the second tier being disposed closer to the fold line 252 than the inner edges of the outer portions 287 a, 288 a.
The portion of the cut lines 250 a, 250 b, 250 c defining the first tier define a recess or aperture A2 in flap 228 a in a folded condition, which recess or aperture A2 is arranged to receive a portion of the second part M of the complementary locking mechanism.
The second part M comprises a foldable tab 280 a, 280 b, 280 c hingedly connected to a second projection along a fold lines 282 a, 282 b, 282 c respectively. The second projections extend from a free edge of a second panel 212, which forms a first base panel of a carton. The fold line 282 a, 282 b, 282 c are interrupted by a cut lines or weakened lines of severance; the cut lines are arcuate in shape and each forms a tab 284 a, 284 b, 284 c which is struck from material forming a respective one of the second projections. The tabs 284 a, 284 b, 284 c are integral with respective ones of the foldable tabs 280 a, 280 b, 280 c. A free end edge of each foldable tab 280 a, 280 b, 280 c opposing the respective fold lines 282 a, 282 b, 282 c is stepped or tiered in shape; an endmost, first, tier defines in part a tongue 292 a disposed centrally within the tab 280 a. Tongue 292 a is sized and arranged to be received in the recess or aperture A2.
Outer portions define in part the second tier of the foldable tab 280 a, each outer portion having an engaging edge 299 a, 299 b respectively; the second tier is disposed in closer proximity to the fold line 282 a than the first tier.
The second tier forms shoulders on either side of the central tongue 292 a.
Preferably, in the folded state, the tab 280 a overlaps with the second panel 212 by a distance Z, as illustrated in FIG. 7; the distance Z is sufficiently large that tab 280 a cannot pass entirely through the aperture A2, even when the flap 228 a is coplanar with the first panel 228.
Turning to the assembly of the complementary locking devices as illustrated in FIGS. 7 to 10, it is envisaged that the complementary locking devices can be formed by a series of sequential folding operations in a straight line machine so that the carton is not required to be rotated or inverted to complete its construction. The folding process is not limited to that described below and may be altered according to particular manufacturing requirements.
FIG. 7 illustrates a stage of assembly of the complementary locking devices. The flap 228 a has been folded about fold line 252. The flap 228 a is illustrated folded to be perpendicular to first panel 228. In other embodiments the flap 228 a may be folded through an angle less than 90 degrees, or may be allowed to at least partially unfold (see FIG. 8), so as to define an obtuse angle between flap 228 a and first panel 228. In folding the flap 228 a, an aperture A2 has been created between the flap 228 a and the first panel 228.
Foldable tabs 280 a, 280 b, 280 c are folded about fold lines 282 a, 282 b, 282 c, into substantially overlapping or overlying relationship with the respective second projection and at least a portion of second panel 212.
The first and second panels 228, 212 are moved with respect to one another as indicated by directional arrows D1, D2 and D3 so as to insert the folded tabs 280 a, 280 b, 280 c into aperture A2. As illustrated in FIG. 9 the tab 280 a, in a folded condition, at least partially passes through the aperture A2. The tab 280 a engages with the aperture A2 created by folding the flap 228 a. The tongue 292 a engages with an upper edge 291 a of the aperture A; upper edge 291 a defines at least in part the recess in which the tongue 292 a is received. In this way the upper edge 291 a restricts the tab 280 a from unfolding. The engaging edges 299 a, 299 b of the outer portions of tab 280 a engage with the flap 228 a at locations disposed adjacent to the recess.
In the illustrated embodiment of FIG. 8, the flap 228 a has unfolded, at least partially, about fold line 252, so as to define an obtuse angle between the flap 228 a and the first panel 228 a. Similarly, the tab 280 a has partially unfolded about fold line 282 a.
Tongue 292 a of tab 280 a is received in the recess.
Shoulder portions 286 a, 285 a engage with those portions of flap 228 a disposed on either side of the recess and defined in part by cut lines 250 a, 250 b, 250 c. Upward travel, unfolding, of the tabs 280 a, 280 b, 280 c is limited by the flap 228 a.
Tab 284 a engages with first panel 228 limiting unfolding of foldable tab 280 a.
It will also be appreciated that tab 280 a in the folded condition is tapered so that it is narrower in width towards the leading edge. This assists in aligning the tab 280 a with the aperture A2, since the leading edge is smaller in dimension than the aperture A2.
It will also be understood that if the tab 280 a is inserted entirely through aperture A2 inadvertently, then the first and second panels 228,212 remain locked together since the tab 280 a, 280 b, 280 b cannot unfold into a flat condition by virtue of the arcuate tab 284 a, 284 b, 284 c, which engages first panel 228 preventing unfolding.
FIG. 9 illustrates the first and second panels 228, 212 in a locked condition. The projection 289 a at least partially overlaps with second panel 212; the projection 289 a being disposed outermost. This overlapping relationship is optional, but when provided increases security by preventing or reducing folding of first panel 228 about fold line 252, thereby helping to maintain first and second panels 228, 212 in a substantially co-planar, or at least substantially parallel, relationship with one another.
The blank 210 provides two locking positions:

- a first locking position in which the endmost male locking tabs 280 a, 280 c are in locking engagement with the endmost (or outer) locking slits 250 a, 250 c or apertures A2 and the of the central foldable tab 280 b of the central male locking tab 280 b is maintained in a folded relationship with respect to the respective second projection to which the central foldable tab 280 b is hinged, the tongues 291 b of the central male locking tabs 280 b is prevented from being received in the respective recess of the flap 228 a, the shoulder portions 286 a, 285 a of the central male locking tab 280 b has not passed through its respective locking slit or aperture and as such the central male locking tab 280 b is not in locking engagement with the flap 228 a;
- a second locking position in which all the locking tabs 280 a, 280 b, 280 c are fully inserted into the respective locking apertures A2 in which they are received, the central locking tab 280 b is in locking engagement (the tongue of the foldable tabs 280 b is received within the respective recess of the a first part F of the complementary locking device defined in flap 228 a) and the shoulder portions 286 a, 285 a of the central male locking tab 280 b has passed through its respective locking slit or aperture such that the central male locking tab 280 b is in locking engagement with the flap 228 a and wherein the endmost foldable tabs 280 a, 280 c are further inserted into the respective apertures A2 such that the engaging edges 299 a, 299 b of the outer portions of endmost foldable tabs 280 a, 280 c are spaced apart from the flap 228 a, in some embodiments the endmost foldable tabs 280 a, 280 c may pass through the apertures A2 in their entirety, in this second position the endmost foldable tabs 280 a, 280 c are substantially prevented or restricted from unfolding or returning to the plane of the second panel 212 by engagement of the tab 284 a, 284 c with the first panel 228.

Referring now to FIG. 10 there is shown a blank 310 for forming a carton according to a fourth embodiment. Blank 310 comprises an alternative locking arrangement which includes comprises a first part M of a complementary locking device and a second part F of a complementary locking device.
In the embodiment of FIG. 10 the male locking tabs 354, 356, 358 have an alternative shape and configuration. There are provided three male locking tabs 354, 356, 358 arranged in a linear series disposed along and extending from a free end edge of the first base panel 212. The endmost male locking tabs 354, 358 comprise an arcuate leading edge which is optionally substantially hemispherical. The endmost male locking tabs 354, 358 comprise a recess which defines a trailing edge for abutment with the second part F of the complementary locking device. The recess in male locking tab 354 is on an opposing side of the male locking tab 354 to the recess in male locking tab 358, preferably the recesses are both on outermost side edges of each of the male locking tabs 354, 358, that is to say the recesses are disposed on the side edge of the male locking tabs 354, 358 in closest proximity to the open ends of the tubular structure defined by the carton walls 312, 314, 316, 318, 320, 322, 324, 326, 328. The central male locking tab 356 comprises an arcuate leading edge, which is optionally substantially hemispherical, and comprises a pair of recesses defined on opposing side edges thereof, the recesses each define a trailing edge for abutment with the second part F of the complementary locking device, in this way the central male locking tab 356 has substantially mushroom shaped appearance.
The recesses struck from the central male locking tab 356 are smaller in dimension than those struck from each of the endmost male locking tabs 354, 358 in this way the trailing edges of the central male locking tab 356 are in closer proximity to the free end edge of the first base panel 312 than the trailing edges of the endmost male locking tabs 354, 358, in this way a carton formed from the blank 310 comprises two distinct locking positions in which the degree of overlap between the first base panel 312 and second base panel 328 can be adjusted so as to increase or decrease the dimension of the tubular structure formed by the carton walls 312, 314, 316, 318, 320, 322, 324, 326, 328. In this way the carton can be adjusted to ensure a tight fit of the carton about its contents, whereby allowing for compensation in dimensional differences of the carton contents.
FIGS. 11 and 12 illustrate a blank 450 for forming a carton according to a fifth embodiment. FIGS. 11 and 12 shows the area of a first base panel 412 and the area of a second base panel 428 only. The other area of the blank 40 is identical to that of the blank 110 of the second embodiment.
Referring to FIG. 11, locking tabs 454, 456, 458, 460 are arranged in first and second groups. The locking tabs 454, 456 in the first group share a common cutline 462 whereas the locking tabs 458, 460 in the second group share a common cutline 463. The locking tabs 454, 456 in the first group are spaced apart from the locking tabs 458, 460 in the second group. More particularly, the locking tab 456 in the first group is spaced apart from the locking tab 458 in the second group. The spacing between the locking tab 456 and the locking tab 458 is greater than the spacing between the adjacent locking tabs 454, 456 of the first group or that between the adjacent locking tabs 458, 460 of the second group. An aperture 455 is defined between the locking tabs 454, 456 which share the common cutline 462 while an aperture 459 is defined between the locking tabs 458, 460 which share the common cutline 463. Each aperture 455, 459 is struck in part from the first base panel 412 and defines in part a recess along the end edge of the first base panel.
Referring to FIG. 12, locking slits 450 a, 450 b, 450 c, 450 d are arranged in two groups and substantially in a linear series. They interrupt the fold line 452 which couples a hinge panel 428 a to the second base panel 428. The locking slit 450 b of the first group is spaced from the locking slit 450 c of the second group. The locking slits 450 a, 450 b of the first group are spaced from one another. The locking slits 450 c, 450 d of the second group are spaced from one another similarly to the locking tabs 450 a, 450 b in terms of spacing. The spacing between the locking slits 450 b, 450 c is greater than the spacing between the locking slits in the first group or in the second group. Each of the locking slits 450 b, 450 c is offset by a distance O with respect to the locking slits 450 a, 450 d. The central locking slits 450 b, 450 c are disposed at a first distance x from the free end edge of the second base panel 428 and the endmost locking slits 450 a, 450 d are disposed at a second distance y from the free end edge of the second base panel 128. The second distance y is less than the first distance x.
It can be appreciated that various changes may be made within the scope of the present invention, for example, the size and shape of the panels and apertures may be adjusted to accommodate articles of differing size or shape. In other embodiments of the invention it is envisaged that the locking arrangement may comprise more than two locking positions; in which further locking tabs and further locking slits respectively are provided for providing further locking positions having greater or lesser degrees of overlap between the first and second base panels than the first and second position disclosed hereinabove, such embodiments may comprise three or more locking positions. In other embodiments it will be appreciated that the locking arrangement may comprise a plurality of male locking tabs offset with respect to each other so as to provide different position of engagement and a plurality of female locking slits or apertures offset with respect to each other so as to provide different position of engagement, in some embodiment the male tabs and female slits may be arranged to give progressively tighter positions of engagement (increasing the degree of overlap between the first and second panels) or they may be arranged such that the offset of the male tabs functions in opposition to the offset of the female tabs so as to cancel one another out, in such an arrangement the carton will only have one locking position but the respective locations at which the male and female portions engage with one another will be offset from one another. For example in one embodiment a locking arrangement is provided comprising two locking tabs projecting from an end edge of a first panel and two locking slits provided adjacent an end edge of the second panel. A locking slit is provided for receiving each of the respective locking tabs, the locking tabs and the locking slits being engageable by relative sliding movement of the locking tabs into the locking slits. A first one of the locking tabs and a first one of the locking slits are configured to secure the pair of panels in an at least partially overlapping relationship. A first point of engagement between the first and second panels is defined by the position that the first locking tabs and the first locking slit engage one another, the first point of engagement and is disposed at first location. A second one of the locking tabs and a second one of the locking slits are also configured to secure the pair of panels in an at least partially overlapping relationship. A second point of engagement between the first and second panels is defined by the position that the second locking tabs and the second locking slit engage one another; the second point of engagement is at second location. The first location is spaced at a first distance from a free end edge the first or second panel and the second location is spaced at a second distance from a free end edge the first or second panel the second distance being greater than the first distance. In this way the first and second points of engagement are offset from one another with respect to an edge of the composite panel formed by securing the first and second panels together; when the locking arrangement is employed in a wraparound style carton the first and second points of engagement are offset from one another with respect to a tubular axis of the carton.
It will be recognised that as used herein, directional references such as “top”, “bottom”, “front”, “back”, “end”, “side”, “inner”, “outer”, “upper” and “lower” do not limit the respective panels to such orientation, but merely serve to distinguish these panels from one another.
As used herein, the terms “hinged connection” and “fold line” refers to all manner of lines that define hinge features of the blank, facilitate folding portions of the blank with respect to one another, or otherwise indicate optimal panel folding locations for the blank. A fold line is typically a scored line, an embossed line, or a debossed line. Any reference to hinged connection or fold line should not be construed as necessarily referring to a single fold line only; indeed it is envisaged that hinged connection can be formed from any one or more of the following, a short slit, a frangible line or a fold line without departing from the scope of the invention.
As used herein, the term “severance line” refers to all manner of lines that facilitate separating portions of the substrate from one another or that indicate optimal separation locations. Severance lines may be frangible or otherwise weakened lines, tear lines, cut lines, or slits.
It should be understood that hinged connection, severance lines and fold lines can each include elements that are formed in the substrate of the blank including perforations, a line of perforations, a line of short slits, a line of half-cuts, a single half-cut, a cut line, an interrupted cut line, slits, scores, any combination thereof, and the like. The elements can be dimensioned and arranged to provide the desired functionality. For example, a line of perforations can be dimensioned or designed with degrees of weakness to define a fold line and/or a severance line. The line of perforations can be designed to facilitate folding and resist breaking, to facilitate folding and facilitate breaking with more effort, or to facilitate breaking with little effort.

Claims

1. A compound of Formula (I)

or a pharmaceutically acceptable salt thereof, wherein;

R¹and R²are each independently hydrogen, C1-6alkyl, C2-6alkenyl or C2-6alkynyl wherein the alkyl, alkenyl or alkynyl are optionally substituted with one up to the maximum number of substituents with one or more of fluoro, —OH, or methyl;

R³and R⁴are each independently hydrogen, or C1-6acyl;

W is

(1) —(CH₂)_m—C(R⁵R⁶)-* wherein m is 1-3, R⁵and R⁶are each independently hydrogen, C1-3alkyl, —OH, halo, or —CF₃, and the * represents the point of attachment to the tetrahydropyran ring;

(2) —(CH₂)_n—CH═C(R⁷)-* wherein n is 0-3, R⁷is hydrogen or —CF₃, and the * represents the point of attachment to the tetrahydropyran ring;

(3) —(CH₂)_p—S(O)₂—CH₂-* wherein p is 0-1, and the * represents the point of attachment to the tetrahydropyran ring; or

(4) —(CH₂)_q—S—CH₂-* wherein q is 0-1 and the * represents the point of attachment to the tetrahydropyran ring; and

X is

(1)

wherein R⁸is hydrogen or C1-3alkoxy,

(2) —C(O)—O—R⁹wherein R⁹is hydrogen, C1-3alkyl, C1-3alkenyl or C1-3alkynyl; or

(3) —C(O)—NR¹⁰R¹¹wherein R¹⁰and R¹¹are each independently hydrogen, C1-3 alkyl, C1-3 alkenyl or C1-3 alkynyl.

2. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R¹and R²are each hydrogen or methyl.

3. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein R³and R⁴are hydrogen.

4. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein W is —(CH₂)_m—C(R⁵R⁶)-* wherein m is 1-3, R⁵and R⁶are each independently hydrogen, C1-3alkyl, —OH, halo, or —CF₃, and the * represents the point of attachment to the tetrahydropyran ring.

5. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein W is —(CH₂)_n—CH═C(R⁷)-* wherein n is 0-3, R⁷is hydrogen or —CF₃, and the * represents the point of attachment to the tetrahydropyran ring.

6. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein W is —(CH₂)_p—S(O)₂—CH₂-* , wherein p is 0-1 and the * represents the point of attachment to the tetrahydropyran ring, or W is —S—(CH₂)_q—S—CH₂-* , wherein q is 0-1 and the * represents the point of attachment to the tetrahydropyran ring.

7. The compound according to claim 1 wherein X is:

wherein R⁸is hydrogen or C1-3alkoxy.

8. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein X is —C(O)—O—R⁹wherein R⁹is hydrogen or C1-3alkyl.

9. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein X is —C(O)—NR¹⁰R¹¹wherein R¹⁰and R¹¹are each independently hydrogen or C1-3alkyl.

10. The compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein

R¹is hydrogen and R²is methyl, or R¹is methyl and R²is hydrogen or R¹and R²are methyl;

R³and R⁴are hydrogen;

W is —(CH₂)_m—C(R⁵R⁶)-* wherein m is 1-2, R⁵and R⁶are each independently hydrogen, —OH, fluoro, or —CF₃, and the * represents the point of attachment to the tetrahydropyran ring; and

X is

wherein R⁸is hydrogen or —OCH₃.

11. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein

R¹is hydrogen and R²is methyl, or R¹is methyl and R²is hydrogen, or R¹and R²are both methyl;

R³and R⁴are hydrogen;

X is —C(O)—O—R⁹wherein R⁹is hydrogen or C1-3alkyl.

12. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein

R³and R⁴are hydrogen;

W is —(CH₂)_m—C(R⁵R⁶)-* wherein m is 0-3, R⁵and R⁶are each independently hydrogen, —OH, fluoro, or —CF₃, and the * represents the point of attachment to the tetrahydropyran ring; and

X is —C(O)—NR¹⁰R¹¹wherein R¹⁰and R¹¹are each independently hydrogen or C1-3alkyl.

13. The compound according to claim 1 or a pharmaceutically acceptable salt thereof wherein

W is —(CH₂)_n—CH═C(R⁷)-* wherein n is 0-1, R⁷is hydrogen or —CF₃, and the * represents the point of attachment to the tetrahydropyran ring; and

X is

(1)

wherein R⁸is hydrogen or C1-3alkoxy, or

(2) —C(O)—O—R⁹wherein R⁹is hydrogen or C1-3alkyl.

14. The compound according to claim 1 which is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

15. A compound of the Formula (II)

or a pharmaceutically acceptable salt thereof, wherein

R¹²and R¹³are each independently hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, wherein the alkyl, alkenyl and alkynyl are optionally substituted from one up to the maximum number of substituents with one or more of fluoro, OH, or methyl;

R¹⁴and R¹⁵are each hydrogen;

Y is —CN, —CH₂—CN, —C≡CH, —CH₂Cl, —C(CH₃)═CH₂, —C(CF₃)═CH₂or —(CH₂)₂NR¹⁶R¹⁷wherein R¹⁶and R¹⁷are each independently hydrogen or C1-3alkyl, —C(C1-3alkyl)₂-Cl, or —C(═CH₂)—C1-3alkyl, and wherein the C1-3alkyl, —C(C1-3alkyl)₂-Cl, or —C(═CH₂)—C1-3alkyl are optionally substituted from one up to the maximum number of substituents with fluoro.

16. The compound according to claim 15 or a pharmaceutically acceptable salt thereof, wherein R¹²is hydrogen and R¹³is methyl or allyl, or R¹²is methyl or allyl and R¹³is hydrogen, or R¹²and R¹³are both methyl.

17. The compound according to claim 15 which is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

18. A compound of the Formula (III)

or a pharmaceutically acceptable salt thereof wherein,

R¹⁸and R¹⁹are each independently hydrogen, C1-6alkyl, C2-6alkenyl, or C2-6alkynyl, wherein the alkyl, alkenyl and alkynyl are optionally substituted from one up to the maximum number of substituents with one or more of fluoro, OH, or methyl.

R²⁰and R²¹are each hydrogen;

R²²is

(1) C1-3alkyl, —OH, C1-3alkoxy, wherein the alkyl and alkoxy are optionally substituted from one up to the maximum number of substituents with one or more of fluoro, —OH, or methyl; or

(2) NR²³R²⁴, wherein R²³is hydrogen or C1-C3alkyl wherein the alkyl is optionally substituted from one up to the maximum number of substituents with one or more of fluoro, OH, or methyl, and R²⁴is C1-3alkyl, C1-3alkoxy, or cyclopropyl, wherein the alkyl, alkoxy and cyclopropyl are optionally substituted from one up to the maximum number of substituents with one or more of fluoro, OH, or methyl.

19. The compound according to claim 18 which is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

20. A pharmaceutical composition comprising the compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

21. A pharmaceutical composition comprising the compound of claim 15 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

22. A pharmaceutical composition comprising the compound of claim 18 or a pharmaceutically acceptable salt thereof.

23. A method for treating a disease or disorder selected from the group consisting of consisting of Alzheimer's disease and related tauopathies, Amyotrophic lateral sclerosis, glaucoma, schizophrenia, Huntington's disease, Parkinson's disease, Schizophrenia, Mild Cognitive Impairment (MCI), Neuropathy and cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

24. A method for treating a disease or disorder selected from the group consisting of consisting of Alzheimer's disease and related tauopathies, Amyotrophic lateral sclerosis, glaucoma, schizophrenia, Huntington's disease, Parkinson's disease, Schizophrenia, Mild Cognitive Impairment (MCI), Neuropathy and cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 15 or a pharmaceutically acceptable salt thereof.

25. A method for treating a disease or disorder selected from the group consisting of consisting of Alzheimer's disease and related tauopathies, Amyotrophic lateral sclerosis, glaucoma, schizophrenia, Huntington's disease, Parkinson's disease, Schizophrenia, Mild Cognitive Impairment (MCI), Neuropathy and cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 18 or a pharmaceutically acceptable salt thereof.