US20160113813A1 - Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops - Google Patents
Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops Download PDFInfo
- Publication number
- US20160113813A1 US20160113813A1 US14/989,458 US201614989458A US2016113813A1 US 20160113813 A1 US20160113813 A1 US 20160113813A1 US 201614989458 A US201614989458 A US 201614989458A US 2016113813 A1 US2016113813 A1 US 2016113813A1
- Authority
- US
- United States
- Prior art keywords
- catheter
- loop
- loops
- lumen
- supply
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F7/123—Devices for heating or cooling internal body cavities using a flexible balloon containing the thermal element
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
- A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0091—Heating or cooling appliances for medical or therapeutic treatment of the human body inflatable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/12—Devices for heating or cooling internal body cavities
- A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
Definitions
- the present application relates generally to patient temperature control systems.
- a catheter includes a proximal segment having a supply lumen configured to receive working fluid from a heat exchange system and a return lumen configured to return working fluid to the heat exchange system.
- the catheter also includes a distal segment in fluid communication with the proximal segment and defining plural spaced apart discrete loops, each communicating with the supply lumen and each being connected to an adjacent loop by a substantially straight connector segment.
- the loops when inflated with working fluid can be toroidal-shaped, disk-shaped, rectangular-shaped or triangular-shaped.
- Each loop can define a proximal surface and a distal surface parallel to the proximal surface and oriented transversely to a long axis of the return tube.
- the distal-most loop can be connected to the return lumen.
- Each individual loop may include a supply port communicating with the supply lumen and a fluid channel defined by the loop and a return port communicating with the supply lumen and with the fluid channel of the loop, such that, working fluid can circulate through the fluid channel from the supply port to the return port.
- the ports can be closely juxtaposed with each other and straddle a separator such that working fluid must flow from the supply port substantially completely through the fluid channel to the return port.
- a catheter in an aspect, includes a series of hollow loops arranged along a tube for carrying working fluid from a heat exchange system to exchange heat with a patient in whom the catheter is advanced.
- the loops When inflated, the loops are oriented transverse to a long axis of the catheter throughout their respective outer peripheries and are parallel to each other.
- the loops circumscribe a hollow passageway through which blood can flow.
- the loops are configured such that blood can also flow around the outer peripheries of the loops.
- a method in an aspect, includes providing a heat exchange catheter with a supply lumen configured for receiving working fluid from a heat exchange system and a return lumen configured for returning working fluid to the heat exchange system.
- the method also includes providing plural discrete loops on the catheter receiving working fluid from the supply lumen and circulating returning working fluid through the loop. The loops are spaced from each other and connected to each other only by a flexible tube.
- FIG. 1 is a schematic diagram showing an example catheter engaged with an example heat exchange system
- FIG. 2 is a perspective view of the heat exchange region showing as an example three spaced apart loops on a catheter with a supply and a return lumen and a single infusion lumen for simplicity, it being understood that additional infusion lumens may be provided;
- FIG. 3 is a transverse view of a loop showing the supply and return ports that communicate with the supply and return lumens, respectively of the catheter;
- FIG. 4 is a transverse cross-section as seen along the line 4 - 4 in FIG. 2 ;
- FIG. 5 is a transverse cross-section of an alternate rectangular embodiment as would be seen along the line 4 - 4 in FIG. 2 ;
- FIG. 6 is a transverse cross-section of an alternate triangular embodiment as would be seen along the line 4 - 4 in FIG. 2 ;
- FIGS. 7 is a cross-section as would be seen along the 7 - 7 in FIG. 2 of an alternate embodiment In which the supply and return ports of a loop are slightly offset axially;
- FIG. 8 shows an alternate embodiment of the distal portion of an alternate embodiment in which the return lumen is distanced from the supply lumen except at the proximal-most portion of the catheter to reduce heat exchange between the lumens.
- an intravascular temperature management catheter 10 is in fluid communication with a catheter temperature control system 12 that includes a processor executing logic that in some non-limiting examples is in accordance with disclosure in the above-referenced system patents to control the temperature of working fluid circulating through the catheter 10 in accordance with a treatment paradigm responsive to patient core temperature feedback signals.
- the catheter 10 can be used to induce therapeutic hypothermia in a patient 14 using the catheter, in which coolant such as but not limited to saline circulates in a closed loop, such that no coolant enters the body.
- coolant such as but not limited to saline circulates in a closed loop, such that no coolant enters the body.
- Such treatment may be indicated for stroke, cardiac arrest (post-resuscitation), acute myocardial infarction, spinal injury, and traumatic brain injury.
- the catheter 10 can also be used to warm a patient, e.g., after bypass surgery or burn treatment, and to combat hyperthermia in, e.g., patient suffering from sub-arachnoid hemorrhage or intracerebral hemorrhage.
- working fluid such a refrigerant may be circulated between the heat exchange system 12 and catheter 10 through supply and return lines 16 , 18 that connect to the proximal end of the catheter 10 as shown.
- proximal and distal in reference to the catheter are relative to the system 12 .
- a patient temperature signal from a catheter-borne temperature sensor may be provided to the system 12 through an electrical line 20 or wirelessly if desired.
- a patient temperature signal may be provided to the system 12 from a separate esophageal probe or rectal probe or tympanic sensor or bladder probe or other temperature probe that measures the temperature of the patient 14 .
- the catheter 10 in addition to interior supply and return lumens through which the working fluid is circulated, may also have one or more infusion lumens connectable to an IV component 22 such as a syringe or IV bag for infusing medicaments into the patient, or an instrument such as an oxygen or pressure monitor for monitoring patient parameters, etc.
- an IV component 22 such as a syringe or IV bag for infusing medicaments into the patient, or an instrument such as an oxygen or pressure monitor for monitoring patient parameters, etc.
- the catheter 10 can be positioned typically in the vasculature of the patient 14 and more preferably in the venous system of the patient 14 such as in the inferior vena cava through a groin insertion point or the superior vena cava through a neck (jugular or subclavian) insertion point.
- a first embodiment of the catheter 10 is shown with a plurality of spaced-apart hollow coolant loops 102 that may be made of medical grade balloon material. While the loops 102 are shown in a disk-shape configuration when inflated with working fluid, in other embodiments the loops 102 may be toroidal-shaped when inflated. In both cases, the loops have the ring-shaped circular transverse cross-sections shown in FIGS. 3 and 4 . Or, the loops may be made to assume an ovular cross-section when inflated. In other embodiments and briefly referring to FIGS. 5 and 6 , the loops may assume non-round transverse shapes when inflated, e.g., rectangular ( FIG. 5 ), triangular ( FIG. 6 ), or other shapes.
- the flexible connector segment 104 includes a supply lumen 106 and a return lumen 108 and is attached to each loop 102 at the base of each loop 102 .
- Each loop 102 may be continuously molded to the connector segment 104 or may be attached to the connector segment 104 by means of an adhesive.
- Additional lumens such as but not limited to an infusion lumen 110 connected to an IV component 22 such as a syringe or IV bag for infusing medicaments into the patient, or an instrument such as an oxygen or pressure monitor for monitoring patient parameters, etc., may be included as part of the connector segment 104 .
- the fluid of the infusion lumen 110 is isolated from the working fluid in the supply lumen 106 and the return lumen 108 and may enter the patient 14 through an open distal end of the catheter 100 .
- each loop 102 defines a proximal surface and a distal surface parallel to the proximal surface and oriented transversely to a long axis of the return tube 108 .
- the loop 102 in FIG. 3 illustrated from a proximal perspective, forms a ring with a supply port 112 on the proximal side of the base of the loop 102 and a return port 114 on the distal side of the base of the loop 102 .
- the working fluid in the proximal supply lumen 106 enters the loop 102 through the supply port 112 and then re-enters the supply lumen 106 through the return port 114 .
- the illustration of a loop 102 in FIG. 4 includes a separator 116 situated between the supply port 112 and return port 114 .
- all but the distal-most loop receives working fluid from the supply lumen 106 on one side of the supply lumen 106 and returns it to the supply lumen 106 on the opposite side of the supply lumen 106 , with the supply lumen 106 being provided with a divider 118 between the two sides to ensure that working fluid flows from the supply lumen 106 , into the supply port 112 of the loop 102 , around the loop 102 , out of the return port 114 , and back into the supply lumen 106 .
- the distal-most loops has a return port 114 connected to a return lumen 108 , which conveys the working fluid proximally back through the catheter 100 to the heat exchange system 12 .
- the supply port 112 and return port 114 of a loop 102 may be slightly axially staggered as shown in FIG. 7 such that the divider 118 in the supply lumen 106 of the catheter 100 extends axially a short way through the supply lumen 106 as shown in FIG. 7 .
- the distal and proximal surfaces of the loop 102 will remain generally parallel to each other but may be angled slightly from being absolutely transverse to the long axis of the catheter 100 owing to axial offset of the supply port 112 and return port 114 .
- each loop 102 in the example shown thus receives coolant from the supply lumen 106 and returns it to the supply lumen 106 , except the distal-most loop, whose return port is connected to the return lumen 108 .
- the separator 116 within each loop 102 to separate the supply port 112 from the return port 114 there is also the blockage 118 in the catheter supply lumen 106 to ensure all coolant in the supply lumen 106 flows through the first loop, back into the supply lumen 106 to the next loop, through the second loop, and so on.
- the flow can be reversed, i.e., the distal most loop can receive working fluid first before all other loops through an elongated straight supply lumen, with the working fluid then being fed back through the other loops in a proximal direction.
- all loops 102 get fed from the supply lumen 106 and the last loop feeds it back to the return lumen 108 ; in the second case the distal loop gets led from the supply lumen 106 , feeding hack the fluid through the return lumen 108 through each subsequent loop in sequence front distal to proximal.
- the distal-most loop 102 does not form a complete ring. Rather, the distal-most loop 102 forms a half-ring and connects to the return lumen 108 , which then extends in a proximal direction through the other loops 102 .
- the working fluid in the supply lumen 106 flows through the loops 102 and back into the supply lumen 106 in a distal-direction until the distal-most loop 102 , at which point the working fluid enters the return lumen 108 and flows in a proximal direction back to the heat exchange system 12 .
- the supply lumen 106 and return lumen 108 in this embodiment are spaced from each other in order to achieve a decreased amount of heat exchange between elements of the catheter 100 and increased heat exchange between the catheter 100 and the patient 14 .
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
Abstract
A catheter has a series of hollow loops arranged along a tube for carrying working fluid from a heat exchange system to exchange heat with a patient in whom the catheter is advanced. The loops when inflated are transverse to the catheter axis and parallel to each other, and circumscribe a hollow passageway through which blood can flow. Blood also flows around the outer perimeters of the loops.
Description
- The present application relates generally to patient temperature control systems.
- It has been discovered that the medical outcome for a patient suffering from severe brain trauma or from ischemia caused by stroke or heart attack or cardiac arrest is improved if the patient is cooled below normal body temperature (73° C.). Furthermore, it is also accepted that for such patients, it is important to prevent hyperthermia (fever) even if it is decided not to induce hypothermia. Moreover, in certain applications such as post-CABG surgery, skin graft surgery, and the like, it might be desirable to rewarm a hypothermic patient.
- As recognized by the present application, the above-mentioned advantages in regulating temperature can be realized by cooling or heating the patient's entire body using a closed loop heat exchange catheter placed in the patient's venous system and circulating a working fluid such as saline through the catheter, heating or cooling the working fluid as appropriate in an external heat exchanger that is connected to the catheter. The following U.S. patents, all of which are incorporated herein by reference, disclose various intravascular catheters/systems/methods for such purposes: U.S. Pat. Nos. 6,881,551 and 6,585,692 (tri-lobe catheter), 6,551,349 and 6,554,797 (metal catheter with bellows), 6,749,625 and 6,796,995 (catheters with non-straight, non-helical heat exchange elements), 6,126,684, 6,299,599, 6,368,304, and 6,338,727 (catheters with multiple heat exchange balloons), 6,146,411, 6,019,783, 6,581,403, 7,287,398, and 5,837,003 (heat exchange systems for catheter), 7,857,781 (various heat exchange catheters),
- The details of the present invention, both as to its structure and operation, can best be understood in reference to the accompanying drawings, in which like reference numerals refer to like parts, and in which:
- A catheter includes a proximal segment having a supply lumen configured to receive working fluid from a heat exchange system and a return lumen configured to return working fluid to the heat exchange system. The catheter also includes a distal segment in fluid communication with the proximal segment and defining plural spaced apart discrete loops, each communicating with the supply lumen and each being connected to an adjacent loop by a substantially straight connector segment.
- The loops when inflated with working fluid can be toroidal-shaped, disk-shaped, rectangular-shaped or triangular-shaped. Each loop can define a proximal surface and a distal surface parallel to the proximal surface and oriented transversely to a long axis of the return tube. The distal-most loop can be connected to the return lumen.
- Each individual loop may include a supply port communicating with the supply lumen and a fluid channel defined by the loop and a return port communicating with the supply lumen and with the fluid channel of the loop, such that, working fluid can circulate through the fluid channel from the supply port to the return port. The ports can be closely juxtaposed with each other and straddle a separator such that working fluid must flow from the supply port substantially completely through the fluid channel to the return port.
- In an aspect, a catheter includes a series of hollow loops arranged along a tube for carrying working fluid from a heat exchange system to exchange heat with a patient in whom the catheter is advanced. When inflated, the loops are oriented transverse to a long axis of the catheter throughout their respective outer peripheries and are parallel to each other. The loops circumscribe a hollow passageway through which blood can flow. The loops are configured such that blood can also flow around the outer peripheries of the loops.
- In an aspect, a method includes providing a heat exchange catheter with a supply lumen configured for receiving working fluid from a heat exchange system and a return lumen configured for returning working fluid to the heat exchange system. The method also includes providing plural discrete loops on the catheter receiving working fluid from the supply lumen and circulating returning working fluid through the loop. The loops are spaced from each other and connected to each other only by a flexible tube.
-
FIG. 1 is a schematic diagram showing an example catheter engaged with an example heat exchange system; -
FIG. 2 is a perspective view of the heat exchange region showing as an example three spaced apart loops on a catheter with a supply and a return lumen and a single infusion lumen for simplicity, it being understood that additional infusion lumens may be provided; -
FIG. 3 is a transverse view of a loop showing the supply and return ports that communicate with the supply and return lumens, respectively of the catheter; -
FIG. 4 is a transverse cross-section as seen along the line 4-4 inFIG. 2 ; -
FIG. 5 is a transverse cross-section of an alternate rectangular embodiment as would be seen along the line 4-4 inFIG. 2 ; -
FIG. 6 is a transverse cross-section of an alternate triangular embodiment as would be seen along the line 4-4 inFIG. 2 ; and -
FIGS. 7 is a cross-section as would be seen along the 7-7 inFIG. 2 of an alternate embodiment In which the supply and return ports of a loop are slightly offset axially; and -
FIG. 8 shows an alternate embodiment of the distal portion of an alternate embodiment in which the return lumen is distanced from the supply lumen except at the proximal-most portion of the catheter to reduce heat exchange between the lumens. - Referring initially to
FIG. 1 , an intravasculartemperature management catheter 10 is in fluid communication with a catheter temperature control system 12 that includes a processor executing logic that in some non-limiting examples is in accordance with disclosure in the above-referenced system patents to control the temperature of working fluid circulating through thecatheter 10 in accordance with a treatment paradigm responsive to patient core temperature feedback signals. In accordance with present principles, thecatheter 10 can be used to induce therapeutic hypothermia in a patient 14 using the catheter, in which coolant such as but not limited to saline circulates in a closed loop, such that no coolant enters the body. Such treatment may be indicated for stroke, cardiac arrest (post-resuscitation), acute myocardial infarction, spinal injury, and traumatic brain injury. Thecatheter 10 can also be used to warm a patient, e.g., after bypass surgery or burn treatment, and to combat hyperthermia in, e.g., patient suffering from sub-arachnoid hemorrhage or intracerebral hemorrhage. - As shown, working fluid such a refrigerant may be circulated between the heat exchange system 12 and
catheter 10 through supply and return lines 16, 18 that connect to the proximal end of thecatheter 10 as shown. Note that as used herein, “proximal” and “distal” in reference to the catheter are relative to the system 12. A patient temperature signal from a catheter-borne temperature sensor may be provided to the system 12 through an electrical line 20 or wirelessly if desired. Alternatively, a patient temperature signal may be provided to the system 12 from a separate esophageal probe or rectal probe or tympanic sensor or bladder probe or other temperature probe that measures the temperature of the patient 14. - The
catheter 10, in addition to interior supply and return lumens through which the working fluid is circulated, may also have one or more infusion lumens connectable to an IV component 22 such as a syringe or IV bag for infusing medicaments into the patient, or an instrument such as an oxygen or pressure monitor for monitoring patient parameters, etc. - The
catheter 10 can be positioned typically in the vasculature of the patient 14 and more preferably in the venous system of the patient 14 such as in the inferior vena cava through a groin insertion point or the superior vena cava through a neck (jugular or subclavian) insertion point. - Now referring to
FIGS. 2-4 , a first embodiment of thecatheter 10, generally designated 100, is shown with a plurality of spaced-aparthollow coolant loops 102 that may be made of medical grade balloon material. While theloops 102 are shown in a disk-shape configuration when inflated with working fluid, in other embodiments theloops 102 may be toroidal-shaped when inflated. In both cases, the loops have the ring-shaped circular transverse cross-sections shown inFIGS. 3 and 4 . Or, the loops may be made to assume an ovular cross-section when inflated. In other embodiments and briefly referring toFIGS. 5 and 6 , the loops may assume non-round transverse shapes when inflated, e.g., rectangular (FIG. 5 ), triangular (FIG. 6 ), or other shapes. - Returning to
FIGS. 2 and 3 , a series ofcoolant loops 102 and a flexible connector segment 104 is shown. The flexible connector segment 104 includes asupply lumen 106 and areturn lumen 108 and is attached to eachloop 102 at the base of eachloop 102. Eachloop 102 may be continuously molded to the connector segment 104 or may be attached to the connector segment 104 by means of an adhesive. Additional lumens, such as but not limited to aninfusion lumen 110 connected to an IV component 22 such as a syringe or IV bag for infusing medicaments into the patient, or an instrument such as an oxygen or pressure monitor for monitoring patient parameters, etc., may be included as part of the connector segment 104. The fluid of theinfusion lumen 110 is isolated from the working fluid in thesupply lumen 106 and thereturn lumen 108 and may enter the patient 14 through an open distal end of thecatheter 100. - In the embodiment shown, each
loop 102 defines a proximal surface and a distal surface parallel to the proximal surface and oriented transversely to a long axis of thereturn tube 108. Theloop 102 inFIG. 3 , illustrated from a proximal perspective, forms a ring with asupply port 112 on the proximal side of the base of theloop 102 and areturn port 114 on the distal side of the base of theloop 102. The working fluid in theproximal supply lumen 106 enters theloop 102 through thesupply port 112 and then re-enters thesupply lumen 106 through thereturn port 114. The illustration of aloop 102 inFIG. 4 includes aseparator 116 situated between thesupply port 112 andreturn port 114. - In this embodiment, all but the distal-most loop receives working fluid from the
supply lumen 106 on one side of thesupply lumen 106 and returns it to thesupply lumen 106 on the opposite side of thesupply lumen 106, with thesupply lumen 106 being provided with a divider 118 between the two sides to ensure that working fluid flows from thesupply lumen 106, into thesupply port 112 of theloop 102, around theloop 102, out of thereturn port 114, and back into thesupply lumen 106. The distal-most loops has areturn port 114 connected to areturn lumen 108, which conveys the working fluid proximally back through thecatheter 100 to the heat exchange system 12. In other embodiments, instead of being radially offset, thesupply port 112 andreturn port 114 of aloop 102 may be slightly axially staggered as shown inFIG. 7 such that the divider 118 in thesupply lumen 106 of thecatheter 100 extends axially a short way through thesupply lumen 106 as shown inFIG. 7 . In such an embodiment, the distal and proximal surfaces of theloop 102 will remain generally parallel to each other but may be angled slightly from being absolutely transverse to the long axis of thecatheter 100 owing to axial offset of thesupply port 112 andreturn port 114. - Note that each
loop 102 in the example shown thus receives coolant from thesupply lumen 106 and returns it to thesupply lumen 106, except the distal-most loop, whose return port is connected to thereturn lumen 108. Note that in addition to theseparator 116 within eachloop 102 to separate thesupply port 112 from thereturn port 114, there is also the blockage 118 in thecatheter supply lumen 106 to ensure all coolant in thesupply lumen 106 flows through the first loop, back into thesupply lumen 106 to the next loop, through the second loop, and so on. Also note that the flow can be reversed, i.e., the distal most loop can receive working fluid first before all other loops through an elongated straight supply lumen, with the working fluid then being fed back through the other loops in a proximal direction. In the first case allloops 102 get fed from thesupply lumen 106 and the last loop feeds it back to thereturn lumen 108; in the second case the distal loop gets led from thesupply lumen 106, feeding hack the fluid through thereturn lumen 108 through each subsequent loop in sequence front distal to proximal. - In the embodiment of the
catheter 100 shown inFIG. 8 , thedistal-most loop 102 does not form a complete ring. Rather, thedistal-most loop 102 forms a half-ring and connects to thereturn lumen 108, which then extends in a proximal direction through theother loops 102. The working fluid in thesupply lumen 106 flows through theloops 102 and back into thesupply lumen 106 in a distal-direction until thedistal-most loop 102, at which point the working fluid enters thereturn lumen 108 and flows in a proximal direction back to the heat exchange system 12. Thesupply lumen 106 and return lumen 108 in this embodiment are spaced from each other in order to achieve a decreased amount of heat exchange between elements of thecatheter 100 and increased heat exchange between thecatheter 100 and the patient 14. - While the particular INTRAVASCULAR HEAT EXCHANGE CATHETER WITH MULTIPLE SPACED APART DISCRETE COOLANT LOOPS is herein shown and described in detail, it is to be understood that the subject matter which is encompassed by the present invention is limited only by the claims.
Claims (20)
1. A catheter, comprising:
a proximal segment having at least one lumen configured to receive working fluid from a heat exchange system; and
a distal segment in fluid communication with the proximal segment and defining plural spaced apart discrete loops, the plural spaced apart discrete loops communicating with the lumen and each being connected to an adjacent loop of the plural spaced apart discrete loops by a connector segment, each loop of the plural spaced apart discrete loops having, when inflated, a wall enclosing a respective loop lumen through which the working fluid can flow and an opening formed by the wall through which fluid external to the catheter can flow, the plural spaced apart discrete loops being connected together by a shaft, wherein at least some loops of the plural spaced apart discrete loops define a respective proximal surface of the respective wall oriented perpendicular to a long axis of the shaft.
2. The catheter of claim 1 , wherein the plural spaced apart discrete loops when inflated are toroidal-shaped.
3. The catheter of claim 1 , wherein the plural spaced apart discrete loops when inflated are disk-shaped.
4. A catheter, comprising:
a proximal segment having a supply lumen configured to receive working fluid from a heat exchange system; and
a distal segment in fluid communication with the proximal segment and defining plural spaced apart loops, at least a first loop having a supply port to receive working fluid from a first side of a divider in the supply lumen and a return port to permit working fluid to reenter the supply lumen on a second side of the divider, a separator being situated between the supply port and return port.
5. The catheter of claim 4 , wherein the supply port is located at a proximal side of a base of the first loop and the return port is located at a distal side of the base of the first loop.
6. The catheter of claim 5 , wherein a distal-most loop different from the first loop includes a return port connected to a return lumen to convey working fluid proximally back to the heat exchange system.
7. The catheter of claim 4 , wherein the supply port is radially offset from the return port.
8. The catheter of claim 4 , wherein the supply port is axially staggered from the return port and the divider in the supply lumen extends axially through the supply lumen.
9. The catheter of claim 8 , wherein distal and proximal surfaces of the first loop are parallel to each other and angled slightly from being absolutely transverse to a long axis of the catheter owing to axial offset of the supply port from the return port.
10. The catheter of claim 4 , wherein the first loop is oriented perpendicular to a long axis of the catheter.
11. A catheter comprising:
loops arranged along a tube for carrying working fluid from a heat exchange system, wherein the loops, when inflated, are oriented perpendicular to a long axis of the catheter throughout respective closed outer peripheries, and are oriented parallel to each other, and circumscribe a hollow passageway through which blood can flow, the loops being configured such that blood also can flow around the closed outer peripheries of the loops, the loops for receiving the working fluid from a supply lumen of a shaft, the supply lumen extending from a proximal segment of the shaft to a supply port of a first one of the loops located most proximally and then again between a return port of the first loop to a supply port of second one of the loops that is located more distally than the first loop.
12. The catheter of claim 11 , wherein the loops when inflated are toroidal-shaped.
13. The catheter of claim 11 , wherein the loops when inflated are disk-shaped.
14. The catheter of claim 11 , wherein at least a first loop has a supply port to receive working fluid from a first side of a divider in the supply lumen and a return port to permit working fluid to reenter the supply lumen on a second side of the divider, a separator being situated between the supply port and return port.
15. The catheter of claim 14 , wherein the supply port is located at a proximal side of a base of the first loop and the return port is located at a distal side of the base of the first loop.
16. The catheter of claim 15 , wherein a distal-most loop different from the first loop includes a return port connected to a return lumen to convey working fluid proximally back to the heat exchange system.
17. The catheter of claim 14 , wherein the supply port is radially offset from the return port.
18. The catheter of claim 14 , wherein the supply port is axially staggered from the return port and the divider in the supply lumen extends axially through the supply lumen.
19. The catheter of claim 18 , wherein distal and proximal surfaces of the first loop are parallel to each other and angled slightly from being absolutely transverse to a long axis of the catheter owing to axial offset of the supply port from the return port.
20. A device comprising:
a shaft with a supply lumen configured for fluid communication with a heat exchange system and a return lumen configured for communicating with the heat exchange system; and
loops coupled to the shaft and fluidly communicating with the supply lumen with a fluid communication path being defined through the loops, the loops being spaced from each other along a longitudinal dimension defined by the shaft, each loop having a wall enclosing a respective lumen and an opening formed by the wall through which fluid external to the catheter can flow, wherein each loop is formed with a respective supply port and a respective return port communicating with the respective lumen of the loop, each loop configured for fluidly communicating with the supply lumen, the supply port being separated from the respective return port, each loop being connected to an adjacent loop by at least one of: the supply lumen, or the return lumen.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/989,458 US20160113813A1 (en) | 2012-09-28 | 2016-01-06 | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261707107P | 2012-09-28 | 2012-09-28 | |
US13/653,648 US9241827B2 (en) | 2012-09-28 | 2012-10-17 | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
US14/989,458 US20160113813A1 (en) | 2012-09-28 | 2016-01-06 | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/653,648 Continuation US9241827B2 (en) | 2012-09-28 | 2012-10-17 | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
Publications (1)
Publication Number | Publication Date |
---|---|
US20160113813A1 true US20160113813A1 (en) | 2016-04-28 |
Family
ID=50385898
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/653,648 Active 2033-05-03 US9241827B2 (en) | 2012-09-28 | 2012-10-17 | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
US14/989,458 Abandoned US20160113813A1 (en) | 2012-09-28 | 2016-01-06 | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/653,648 Active 2033-05-03 US9241827B2 (en) | 2012-09-28 | 2012-10-17 | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
Country Status (4)
Country | Link |
---|---|
US (2) | US9241827B2 (en) |
EP (1) | EP2827814B1 (en) |
JP (1) | JP6395265B2 (en) |
WO (1) | WO2014051990A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11504517B2 (en) | 2015-12-11 | 2022-11-22 | Nxstage Medical, Inc. | Fluid line connector devices methods and systems |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9241827B2 (en) * | 2012-09-28 | 2016-01-26 | Zoll Circulation, Inc. | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
US9801756B2 (en) | 2012-09-28 | 2017-10-31 | Zoll Circulation, Inc. | Intravascular heat exchange catheter and system with RFID coupling |
US9474644B2 (en) | 2014-02-07 | 2016-10-25 | Zoll Circulation, Inc. | Heat exchange system for patient temperature control with multiple coolant chambers for multiple heat exchange modalities |
US11033424B2 (en) | 2014-02-14 | 2021-06-15 | Zoll Circulation, Inc. | Fluid cassette with tensioned polymeric membranes for patient heat exchange system |
US10792185B2 (en) | 2014-02-14 | 2020-10-06 | Zoll Circulation, Inc. | Fluid cassette with polymeric membranes and integral inlet and outlet tubes for patient heat exchange system |
US11359620B2 (en) | 2015-04-01 | 2022-06-14 | Zoll Circulation, Inc. | Heat exchange system for patient temperature control with easy loading high performance peristaltic pump |
US9784263B2 (en) | 2014-11-06 | 2017-10-10 | Zoll Circulation, Inc. | Heat exchange system for patient temperature control with easy loading high performance peristaltic pump |
US11213423B2 (en) | 2015-03-31 | 2022-01-04 | Zoll Circulation, Inc. | Proximal mounting of temperature sensor in intravascular temperature management catheter |
US10537465B2 (en) | 2015-03-31 | 2020-01-21 | Zoll Circulation, Inc. | Cold plate design in heat exchanger for intravascular temperature management catheter and/or heat exchange pad |
US10022265B2 (en) | 2015-04-01 | 2018-07-17 | Zoll Circulation, Inc. | Working fluid cassette with hinged plenum or enclosure for interfacing heat exchanger with intravascular temperature management catheter |
US10758406B2 (en) * | 2016-12-30 | 2020-09-01 | Zoll Circulation, Inc. | High efficiency heat exchange catheters for control of patient body temperature |
US11116657B2 (en) | 2017-02-02 | 2021-09-14 | Zoll Circulation, Inc. | Devices, systems and methods for endovascular temperature control |
US11337851B2 (en) | 2017-02-02 | 2022-05-24 | Zoll Circulation, Inc. | Devices, systems and methods for endovascular temperature control |
US11185440B2 (en) | 2017-02-02 | 2021-11-30 | Zoll Circulation, Inc. | Devices, systems and methods for endovascular temperature control |
US11497648B2 (en) | 2017-05-12 | 2022-11-15 | Zoll Circulation, Inc. | Advanced systems and methods for patient body temperature control |
US11992433B2 (en) | 2017-05-12 | 2024-05-28 | Zoll Circulation, Inc. | Advanced systems and methods for patient body temperature control |
US11865035B2 (en) | 2019-03-29 | 2024-01-09 | Zoll Circulation, Inc. | Transport battery for use with portable thermal management system |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040044387A1 (en) * | 2002-08-30 | 2004-03-04 | Hortensia Pompa | Intravascular temperature control catheter |
US9241827B2 (en) * | 2012-09-28 | 2016-01-26 | Zoll Circulation, Inc. | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
Family Cites Families (173)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1459112A (en) | 1922-02-23 | 1923-06-19 | Charles F Mehl | Invalid bed |
US1857031A (en) | 1929-08-02 | 1932-05-03 | Schaffer Edward | Combined hoist and conveyer |
GB659339A (en) | 1948-04-26 | 1951-10-24 | Bengt Rudolf Dahlberg | Improvements in apparatus for lifting, temporarily supporting and transferring persons in a reclining position |
US2673987A (en) | 1951-10-22 | 1954-04-06 | James L Upshaw | Invalid carrier with rotatable chair |
US3225191A (en) | 1962-06-01 | 1965-12-21 | Industrial Dynamics Co | Infrared liquid level inspection system |
US3425419A (en) | 1964-08-08 | 1969-02-04 | Angelo Actis Dato | Method of lowering and raising the temperature of the human body |
US3369549A (en) | 1965-10-05 | 1968-02-20 | Thomas A. Armao | Capsule probe having thermoelectric heat exchange means therein |
US3504674A (en) | 1966-12-22 | 1970-04-07 | Emil S Swenson | Method and apparatus for performing hypothermia |
GB1183185A (en) | 1967-03-06 | 1970-03-04 | Sp K B Poluprovodnikovykh Prib | Apparatus for Controlling the Temperature of a Living Body |
US3744555A (en) | 1971-11-12 | 1973-07-10 | Gen Electric | Automatic control of liquid cooling garment by cutaneous and external auditory meatus temperatures |
US3726269A (en) | 1971-11-24 | 1973-04-10 | W Webster | Cardiovascular catheter for thermal dilution measurement |
US3751077A (en) | 1972-02-28 | 1973-08-07 | Imp Eastman Corp | Welded sleeve fitting |
NL7414546A (en) | 1973-11-15 | 1975-05-20 | Rhone Poulenc Sa | SMOOTH HEATING TUBE AND PROCESS FOR MANUFACTURING IT. |
JPS5247636B2 (en) | 1973-12-15 | 1977-12-03 | ||
US3937224A (en) | 1974-04-11 | 1976-02-10 | Uecker Ronald L | Colostomy catheter |
US4126132A (en) | 1975-07-28 | 1978-11-21 | Andros Incorporated | Intravenous and intra arterial delivery system |
US4065264A (en) | 1976-05-10 | 1977-12-27 | Shiley Laboratories, Inc. | Blood oxygenator with integral heat exchanger for regulating the temperature of blood in an extracorporeal circuit |
US4103511A (en) | 1976-10-04 | 1978-08-01 | Firma Kress Elektrik Gmbh & Co. | Connecting arrangement for a machine tool |
US4173228A (en) | 1977-05-16 | 1979-11-06 | Applied Medical Devices | Catheter locating device |
US4181132A (en) | 1977-05-31 | 1980-01-01 | Parks Leon C | Method and apparatus for effecting hyperthermic treatment |
US4153048A (en) | 1977-09-14 | 1979-05-08 | Cleveland Clinic Foundation | Thermodilution catheter and method |
US4259961A (en) | 1979-01-24 | 1981-04-07 | Hood Iii Andrew G | Cooling pad |
US4298006A (en) | 1980-04-30 | 1981-11-03 | Research Against Cancer, Inc. | Systemic hyperthermia with improved temperature sensing apparatus and method |
US4532414A (en) | 1980-05-12 | 1985-07-30 | Data Chem., Inc. | Controlled temperature blood warming apparatus |
US4459468A (en) | 1982-04-14 | 1984-07-10 | Bailey David F | Temperature control fluid circulating system |
US5370675A (en) | 1992-08-12 | 1994-12-06 | Vidamed, Inc. | Medical probe device and method |
US4581017B1 (en) | 1983-03-07 | 1994-05-17 | Bard Inc C R | Catheter systems |
US4554793A (en) | 1983-06-09 | 1985-11-26 | General Eastern Instruments Corporation | Controlled power converter for thermoelectric heat pump drive |
JPS6028085A (en) | 1983-07-25 | 1985-02-13 | Canon Inc | Head driver of recording or reproducing device |
US4672962A (en) | 1983-09-28 | 1987-06-16 | Cordis Corporation | Plaque softening method |
US4653987A (en) | 1984-07-06 | 1987-03-31 | Tsuyoshi Tsuji | Finger peristaltic infusion pump |
US4638436A (en) | 1984-09-24 | 1987-01-20 | Labthermics Technologies, Inc. | Temperature control and analysis system for hyperthermia treatment |
US4661094A (en) | 1985-05-03 | 1987-04-28 | Advanced Cardiovascular Systems | Perfusion catheter and method |
SE8504501D0 (en) | 1985-09-30 | 1985-09-30 | Astra Meditec Ab | METHOD OF FORMING AN IMPROVED HYDROPHILIC COATING ON A POLYMER SURFACE |
CH668192A5 (en) | 1985-11-29 | 1988-12-15 | Schneider Medintag Ag | CATHETER FOR TREATING NARROW BODIES, FOR EXAMPLE IN A BLOOD VESSEL. |
US4665391A (en) | 1986-02-27 | 1987-05-12 | Warner-Lambert Company | Empty container detector |
US4754752A (en) | 1986-07-28 | 1988-07-05 | Robert Ginsburg | Vascular catheter |
JPS63159300A (en) | 1986-12-23 | 1988-07-02 | Shin Etsu Chem Co Ltd | Production of silicon carbide whisker |
US4813855A (en) | 1987-06-26 | 1989-03-21 | Tek-Aids Inc. | Peristaltic pump |
JPS6446056U (en) | 1987-09-17 | 1989-03-22 | ||
US4860744A (en) | 1987-11-02 | 1989-08-29 | Raj K. Anand | Thermoelectrically controlled heat medical catheter |
GB2212262B (en) | 1987-11-09 | 1992-07-22 | Solinst Canada Ltd | Liquid level detector |
US4852567A (en) | 1988-01-21 | 1989-08-01 | C. R. Bard, Inc. | Laser tipped catheter |
US4941475A (en) | 1988-08-30 | 1990-07-17 | Spectramed, Inc. | Thermodilution by heat exchange |
US6551347B1 (en) * | 1988-09-28 | 2003-04-22 | Life Enhancement Technologies, Inc. | Cooling/heating system |
JPH03502732A (en) | 1988-10-20 | 1991-06-20 | コナックス バッファロウ コーポレーション | optical level sensor |
FR2693116B1 (en) | 1992-07-06 | 1995-04-28 | Technomed Int Sa | Urethral probe and apparatus for the therapeutic treatment of prostate tissue by thermotherapy. |
US5037392A (en) * | 1989-06-06 | 1991-08-06 | Cordis Corporation | Stent-implanting balloon assembly |
US5174285A (en) | 1990-01-08 | 1992-12-29 | Lake Shore Medical Development Partners Ltd. | Localized heat transfer device |
US5624392A (en) | 1990-05-11 | 1997-04-29 | Saab; Mark A. | Heat transfer catheters and methods of making and using same |
US5342301A (en) | 1992-08-13 | 1994-08-30 | Advanced Polymers Incorporated | Multi-lumen balloons and catheters made therewith |
US5092841A (en) | 1990-05-17 | 1992-03-03 | Wayne State University | Method for treating an arterial wall injured during angioplasty |
US5507792A (en) | 1990-09-05 | 1996-04-16 | Breg, Inc. | Therapeutic treatment device having a heat transfer element and a pump for circulating a treatment fluid therethrough |
US5584804A (en) | 1990-10-10 | 1996-12-17 | Life Resuscitation Technologies, Inc. | Brain resuscitation and organ preservation device and method for performing the same |
US5195965A (en) | 1991-03-07 | 1993-03-23 | Shantha Totada R | Method and apparatus for localized treatment of human viral infections and cancers |
JP3091253B2 (en) | 1991-04-25 | 2000-09-25 | オリンパス光学工業株式会社 | Thermal treatment equipment |
US5192274A (en) | 1991-05-08 | 1993-03-09 | Bierman Steven F | Anchor pad for catheterization system |
US5211631A (en) | 1991-07-24 | 1993-05-18 | Sheaff Charles M | Patient warming apparatus |
GB9118670D0 (en) | 1991-08-30 | 1991-10-16 | Mcnicholas Thomas A | Surgical devices and uses thereof |
US5304214A (en) | 1992-01-21 | 1994-04-19 | Med Institute, Inc. | Transurethral ablation catheter |
US6059825A (en) | 1992-03-05 | 2000-05-09 | Angiodynamics, Inc. | Clot filter |
US5281215A (en) | 1992-04-16 | 1994-01-25 | Implemed, Inc. | Cryogenic catheter |
US5269758A (en) | 1992-04-29 | 1993-12-14 | Taheri Syde A | Intravascular catheter and method for treatment of hypothermia |
DE4221390C1 (en) | 1992-06-30 | 1993-04-01 | Haindl, Hans, Dr.Med., 3015 Wennigsen, De | |
US5403281A (en) | 1992-09-25 | 1995-04-04 | Minnesota Mining And Manufacturing Company | Inline heat exchanger and cardioplegia system |
US5304519A (en) | 1992-10-28 | 1994-04-19 | Praxair S.T. Technology, Inc. | Powder feed composition for forming a refraction oxide coating, process used and article so produced |
US6325067B1 (en) | 1992-12-03 | 2001-12-04 | Wesley D. Sterman | Methods and systems for performing thoracoscopic coronary bypass and other procedures |
US5437673A (en) | 1993-02-04 | 1995-08-01 | Cryomedical Sciences, Inc. | Closed circulation tissue warming apparatus and method of using the same in prostate surgery |
US5837003A (en) | 1993-02-10 | 1998-11-17 | Radiant Medical, Inc. | Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification |
US6620188B1 (en) | 1998-08-24 | 2003-09-16 | Radiant Medical, Inc. | Methods and apparatus for regional and whole body temperature modification |
US5383856A (en) | 1993-03-19 | 1995-01-24 | Bersin; Robert M. | Helical spiral balloon catheter |
US5626618A (en) | 1993-09-24 | 1997-05-06 | The Ohio State University | Mechanical adjunct to cardiopulmonary resuscitation (CPR), and an electrical adjunct to defibrillation countershock, cardiac pacing, and cardiac monitoring |
US6716216B1 (en) | 1998-08-14 | 2004-04-06 | Kyphon Inc. | Systems and methods for treating vertebral bodies |
JP3442863B2 (en) | 1994-06-10 | 2003-09-02 | 隆 松浦 | Patient bed with release frame and moving device for release frame |
US5716386A (en) | 1994-06-27 | 1998-02-10 | The Ohio State University | Non-invasive aortic impingement and core and cerebral temperature manipulation |
US5458639A (en) | 1994-08-05 | 1995-10-17 | Medtronic, Inc. | Catheter balloon distal bond |
EP0698940B1 (en) | 1994-08-24 | 2000-06-14 | Sumitomo Wiring Systems, Ltd. | Wiring circuit for an electrical connection box, method and apparatus for forming the wiring circuit |
US5486207A (en) | 1994-09-20 | 1996-01-23 | Mahawili; Imad | Thermal pad for portable body heating/cooling system and method of use |
US5643315A (en) * | 1994-09-22 | 1997-07-01 | Daneshvar; Yousef | Device for wound therapy and prevention of bleeding |
US5895418A (en) | 1994-09-30 | 1999-04-20 | Saringer Research Inc. | Device for producing cold therapy |
US5531714A (en) | 1994-11-01 | 1996-07-02 | M. Patricia Lange | Self-guiding, multifunctional visceral catheter |
US5634907A (en) | 1994-12-22 | 1997-06-03 | Sandoz Nutrition Ltd. | System for detection of fluid infusion |
US5980561A (en) | 1995-03-01 | 1999-11-09 | Kolen; Paul T. | Applying thermal therapy to living tissue |
DE19531935A1 (en) | 1995-08-17 | 1997-02-20 | Panagiotis Tsolkas | Device for whole body hyperthermia treatment |
US5730720A (en) | 1995-08-18 | 1998-03-24 | Ip Scientific, Inc. | Perfusion hyperthermia treatment system and method |
US5701905A (en) | 1995-11-13 | 1997-12-30 | Localmed, Inc. | Guide catheter with sensing element |
DE29602173U1 (en) | 1996-02-08 | 1997-06-26 | B. Braun Melsungen Ag, 34212 Melsungen | Application device for medical liquids |
US5733319A (en) | 1996-04-25 | 1998-03-31 | Urologix, Inc. | Liquid coolant supply system |
US5676670A (en) | 1996-06-14 | 1997-10-14 | Beth Israel Deaconess Medical Center | Catheter apparatus and method for creating a vascular bypass in-vivo |
US5776079A (en) | 1996-08-06 | 1998-07-07 | Cook Incorporated | Retrograde-antegrade catheterization guide wire |
EP0929786B1 (en) | 1996-10-02 | 2003-02-12 | Kehl, Hermann | Laser pistol |
US5849016A (en) | 1996-12-03 | 1998-12-15 | Suhr; William S. | Catheter exchange method and apparatus |
US6124452A (en) | 1997-12-19 | 2000-09-26 | University Of Nebraska-Lincoln | Octafluoro-meso-tetraarylporphyrins and methods for making these compounds |
US5788647A (en) | 1997-01-24 | 1998-08-04 | Eggers; Philip E. | Method, system and apparatus for evaluating hemodynamic parameters |
US6110097A (en) | 1997-03-06 | 2000-08-29 | Scimed Life Systems, Inc. | Perfusion balloon catheter with radioactive source |
EP0969769A2 (en) | 1997-03-12 | 2000-01-12 | Advanced Closure Systems, Inc. | Vascular sealing device |
JPH10305103A (en) | 1997-05-08 | 1998-11-17 | Nippon Sherwood Medical Ind Ltd | Catheter fixing tool |
US5862675A (en) | 1997-05-30 | 1999-01-26 | Mainstream Engineering Corporation | Electrically-driven cooling/heating system utilizing circulated liquid |
US5908407A (en) | 1997-07-25 | 1999-06-01 | Neuroperfusion, Inc. | Retroperfusion catheter apparatus and method |
US6283940B1 (en) | 1997-08-29 | 2001-09-04 | S. Grant Mulholland | Catheter |
US6110139A (en) | 1997-10-21 | 2000-08-29 | Loubser; Paul Gerhard | Retrograde perfusion monitoring and control system |
US6117105A (en) | 1997-12-08 | 2000-09-12 | Cardeon Corporation | Aortic catheter and methods for inducing cardioplegic arrest and for selective aortic perfusion |
US6464716B1 (en) | 1998-01-23 | 2002-10-15 | Innercool Therapies, Inc. | Selective organ cooling apparatus and method |
US6096068A (en) | 1998-01-23 | 2000-08-01 | Innercool Therapies, Inc. | Selective organ cooling catheter and method of using the same |
US6231595B1 (en) | 1998-03-31 | 2001-05-15 | Innercool Therapies, Inc. | Circulating fluid hypothermia method and apparatus |
US6843800B1 (en) | 1998-01-23 | 2005-01-18 | Innercool Therapies, Inc. | Patient temperature regulation method and apparatus |
US6719779B2 (en) | 2000-11-07 | 2004-04-13 | Innercool Therapies, Inc. | Circulation set for temperature-controlled catheter and method of using the same |
US6051019A (en) | 1998-01-23 | 2000-04-18 | Del Mar Medical Technologies, Inc. | Selective organ hypothermia method and apparatus |
US6042559A (en) | 1998-02-24 | 2000-03-28 | Innercool Therapies, Inc. | Insulated catheter for selective organ perfusion |
US6551349B2 (en) * | 1998-03-24 | 2003-04-22 | Innercool Therapies, Inc. | Selective organ cooling apparatus |
US6599312B2 (en) | 1998-03-24 | 2003-07-29 | Innercool Therapies, Inc. | Isolated selective organ cooling apparatus |
US7001378B2 (en) * | 1998-03-31 | 2006-02-21 | Innercool Therapies, Inc. | Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection |
US6338727B1 (en) | 1998-08-13 | 2002-01-15 | Alsius Corporation | Indwelling heat exchange catheter and method of using same |
US6581403B2 (en) | 2001-09-25 | 2003-06-24 | Alsius Corporation | Heating/cooling system for indwelling heat exchange catheter |
US6530946B1 (en) | 1998-04-21 | 2003-03-11 | Alsius Corporation | Indwelling heat exchange heat pipe catheter and method of using same |
US6520933B1 (en) * | 1998-04-21 | 2003-02-18 | Alsius Corporation | Central venous line cooling catheter having a spiral-shaped heat exchange member |
US6149670A (en) * | 1999-03-11 | 2000-11-21 | Alsius Corporation | Method and system for treating cardiac arrest using hypothermia |
US6126684A (en) | 1998-04-21 | 2000-10-03 | The Regents Of The University Of California | Indwelling heat exchange catheter and method of using same |
US6419643B1 (en) * | 1998-04-21 | 2002-07-16 | Alsius Corporation | Central venous catheter with heat exchange properties |
US6589271B1 (en) * | 1998-04-21 | 2003-07-08 | Alsius Corporations | Indwelling heat exchange catheter |
US7287398B2 (en) | 2001-09-25 | 2007-10-30 | Alsius Corporation | Heating/cooling system for indwelling heat exchange catheter |
US8128595B2 (en) * | 1998-04-21 | 2012-03-06 | Zoll Circulation, Inc. | Method for a central venous line catheter having a temperature control system |
US6450990B1 (en) | 1998-08-13 | 2002-09-17 | Alsius Corporation | Catheter with multiple heating/cooling fibers employing fiber spreading features |
US6312461B1 (en) | 1998-08-21 | 2001-11-06 | John D. Unsworth | Shape memory tubular stent |
US6610083B2 (en) | 1998-08-24 | 2003-08-26 | Radiant Medical, Inc. | Multiple lumen heat exchange catheters |
US6428563B1 (en) | 2000-01-21 | 2002-08-06 | Radiant Medical, Inc. | Heat exchange catheter with improved insulated region |
US6146411A (en) | 1998-12-24 | 2000-11-14 | Alsius Corporation | Cooling system for indwelling heat exchange catheter |
JP2002534160A (en) | 1999-01-04 | 2002-10-15 | メディヴァンス インコーポレイテッド | Improved cooling / heating pads and systems |
US6299599B1 (en) | 1999-02-19 | 2001-10-09 | Alsius Corporation | Dual balloon central venous line catheter temperature control system |
US6019783A (en) | 1999-03-02 | 2000-02-01 | Alsius Corporation | Cooling system for therapeutic catheter |
US6148634A (en) | 1999-04-26 | 2000-11-21 | 3M Innovative Properties Company | Multistage rapid product refrigeration apparatus and method |
US6436071B1 (en) | 1999-06-08 | 2002-08-20 | The Trustees Of Columbia University In The City Of New York | Intravascular systems for corporeal cooling |
US6287326B1 (en) * | 1999-08-02 | 2001-09-11 | Alsius Corporation | Catheter with coiled multi-lumen heat transfer extension |
US6231594B1 (en) | 1999-08-11 | 2001-05-15 | Radiant Medical, Inc. | Method of controlling body temperature while reducing shivering |
US6264679B1 (en) | 1999-08-20 | 2001-07-24 | Radiant Medical, Inc. | Heat exchange catheter with discrete heat exchange elements |
US20040089058A1 (en) | 1999-09-09 | 2004-05-13 | De Haan Peter Hillebrand | Sensor for detecting the presence of moisture |
US6554791B1 (en) | 1999-09-29 | 2003-04-29 | Smisson-Cartledge Biomedical, Llc | Rapid infusion system |
AU4713601A (en) | 1999-12-07 | 2001-06-18 | Alsius Corporation | Method and system for treating stroke using hypothermia |
WO2001043661A2 (en) | 1999-12-14 | 2001-06-21 | Radiant Medical, Inc. | Method for reducing myocardial infarct by applicaton of intravascular hypothermia |
US6383144B1 (en) | 2000-01-18 | 2002-05-07 | Edwards Lifesciences Corporation | Devices and methods for measuring temperature of a patient |
US6624679B2 (en) | 2000-01-31 | 2003-09-23 | Stmicroelectronics S.R.L. | Stabilized delay circuit |
CA2401222C (en) | 2000-02-28 | 2010-04-27 | Radiant Medical, Inc. | Disposable cassette for intravascular heat exchange catheter |
CA2404430A1 (en) | 2000-04-07 | 2001-10-18 | Albert S. Lee | Methods and apparatus for thermally affecting tissue |
WO2001083001A1 (en) | 2000-05-02 | 2001-11-08 | Vasca, Inc. | Methods and devices for draining fluids in and out of the body |
US6551309B1 (en) | 2000-09-14 | 2003-04-22 | Cryoflex, Inc. | Dual action cryoprobe and methods of using the same |
US6719723B2 (en) | 2000-12-06 | 2004-04-13 | Innercool Therapies, Inc. | Multipurpose catheter assembly |
US6544282B1 (en) | 2001-02-21 | 2003-04-08 | Radiant Medical, Inc. | Inhibition of platelet activation, aggregation and/or adhesion by hypothermia |
WO2002078513A2 (en) | 2001-03-30 | 2002-10-10 | Augmentech, Inc. | Patient incontinence/position monitoring apparatus and method of use thereof |
US6699269B2 (en) | 2001-04-30 | 2004-03-02 | Rohit K. Khanna | Selective brain and spinal cord hypothermia method and apparatus |
DE10121722A1 (en) | 2001-05-04 | 2002-11-07 | Cognis Deutschland Gmbh | Gemini surfactants in rinse aid |
US7057273B2 (en) | 2001-05-15 | 2006-06-06 | Gem Services, Inc. | Surface mount package |
US6752786B2 (en) | 2001-05-31 | 2004-06-22 | Radiant Medical, Inc. | Moving heat exchange catheter system |
US6706060B2 (en) * | 2001-06-05 | 2004-03-16 | Alsius Corporation | Heat exchange catheter |
US6733517B1 (en) * | 2001-06-13 | 2004-05-11 | Alsius Corporation | Angling introducer sheath for catheter having temperature control system |
US6679906B2 (en) | 2001-07-13 | 2004-01-20 | Radiant Medical, Inc. | Catheter system with on-board temperature probe |
GB0125294D0 (en) | 2001-10-22 | 2001-12-12 | Bickford Smith Philip | Medical small-bore tubing connectors |
US8353945B2 (en) | 2001-12-03 | 2013-01-15 | J.W. Medical System Ltd. | Delivery catheter having active engagement mechanism for prosthesis |
US6685733B1 (en) | 2002-04-10 | 2004-02-03 | Radiant Medical, Inc. | Methods and systems for reducing substance-induced renal damage |
US6969399B2 (en) | 2002-07-11 | 2005-11-29 | Life Recovery Systems Hd, Llc | Apparatus for altering the body temperature of a patient |
US6796995B2 (en) * | 2002-08-30 | 2004-09-28 | Alsius Corporation | Intravascular temperature control catheter |
AU2003270600B2 (en) | 2002-09-12 | 2008-08-14 | Radiant Medical, Inc. | System and method for determining and controlling core body temperature |
US6887263B2 (en) | 2002-10-18 | 2005-05-03 | Radiant Medical, Inc. | Valved connector assembly and sterility barriers for heat exchange catheters and other closed loop catheters |
US7001418B2 (en) * | 2003-04-30 | 2006-02-21 | Alsius Corporation | Intravascular heat exchange catheter with insulated coolant tubes |
US6799342B1 (en) | 2003-05-27 | 2004-10-05 | Robert G. Jarmon | Method and apparatus for supporting a body |
US20050156744A1 (en) | 2003-09-02 | 2005-07-21 | Pires Harold G. | Diaper wetness annunciator system |
FR2863162B1 (en) | 2003-12-05 | 2006-12-08 | Vygon | MALE FITTINGS AND FEMALE FITTINGS FOR REALIZING LIQUID TRANSMISSION CONNECTIONS, IN PARTICULAR FOR ENTERALE NUTRITION LINES |
US8012201B2 (en) | 2004-05-05 | 2011-09-06 | Direct Flow Medical, Inc. | Translumenally implantable heart valve with multiple chamber formed in place support |
US7822485B2 (en) | 2006-09-25 | 2010-10-26 | Zoll Circulation, Inc. | Method and apparatus for spinal cooling |
WO2009001325A1 (en) * | 2007-06-27 | 2008-12-31 | Flip Technologies Limited | A device and a system for use in a procedure for improving a sealing function of a sphincter and a method for improving the sealing function of a sphincter |
US10045881B2 (en) * | 2011-09-28 | 2018-08-14 | Zoll Circulation, Inc. | Patient temperature control catheter with helical heat exchange paths |
US9314370B2 (en) * | 2011-09-28 | 2016-04-19 | Zoll Circulation, Inc. | Self-centering patient temperature control catheter |
WO2013049672A1 (en) * | 2011-09-30 | 2013-04-04 | Zoll Circulation, Inc. | Heat exchange catheters and their methods of manufacture and use |
US9662243B2 (en) * | 2011-09-30 | 2017-05-30 | Zoll Circulation, Inc. | Heat exchange catheters with bi-directional fluid flow and their methods of manufacture and use |
-
2012
- 2012-10-17 US US13/653,648 patent/US9241827B2/en active Active
-
2013
- 2013-09-10 WO PCT/US2013/058936 patent/WO2014051990A2/en active Application Filing
- 2013-09-10 JP JP2015511817A patent/JP6395265B2/en not_active Expired - Fee Related
- 2013-09-10 EP EP13840225.0A patent/EP2827814B1/en active Active
-
2016
- 2016-01-06 US US14/989,458 patent/US20160113813A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040044387A1 (en) * | 2002-08-30 | 2004-03-04 | Hortensia Pompa | Intravascular temperature control catheter |
US9241827B2 (en) * | 2012-09-28 | 2016-01-26 | Zoll Circulation, Inc. | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11504517B2 (en) | 2015-12-11 | 2022-11-22 | Nxstage Medical, Inc. | Fluid line connector devices methods and systems |
Also Published As
Publication number | Publication date |
---|---|
US20140094880A1 (en) | 2014-04-03 |
EP2827814A4 (en) | 2016-11-02 |
JP2015527089A (en) | 2015-09-17 |
US9241827B2 (en) | 2016-01-26 |
EP2827814A2 (en) | 2015-01-28 |
EP2827814B1 (en) | 2019-11-06 |
WO2014051990A2 (en) | 2014-04-03 |
WO2014051990A3 (en) | 2015-07-30 |
JP6395265B2 (en) | 2018-09-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US9241827B2 (en) | Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops | |
US10596029B2 (en) | Intravascular heat exchange catheter with rib cage-like coolant path | |
US20180338858A1 (en) | Patient temperature control catheter with helical heat exchange paths | |
US9402764B2 (en) | Self-centering patient temperature control catheter | |
US9717625B2 (en) | Intravascular heat exchange catheter with non-round coiled coolant path | |
US10561526B2 (en) | Transatrial patient temperature control catheter | |
US8888832B2 (en) | System and method for doubled use of patient temperature control catheter |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STPP | Information on status: patent application and granting procedure in general |
Free format text: RESPONSE TO NON-FINAL OFFICE ACTION ENTERED AND FORWARDED TO EXAMINER |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NON FINAL ACTION MAILED |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |