US20160108473A1 - Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof - Google Patents

Abstract

The present invention provides compositions and methods based on genetic polymorphisms that are associated with response to statin treatment, particularly for reducing the risk of cardiovascular disease, especially coronary heart disease (such as myocardial infarction) and stroke. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents and kits for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents and kits for their detection.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS
• This application is a continuation application of U.S. non-provisional application Ser. No. 13/833,905, dated Mar. 15, 2013, which is a continuation application of U.S. non-provisional application Ser. No. 13/085,955, dated Apr. 13, 2011, which claims the benefit of U.S. provisional application Ser. No. 61/325,689 filed Apr. 19, 2010, U.S. provisional application Ser. No. 61/332,509 filed May 7, 2010, and U.S. provisional application Ser. No. 61/405,972 filed Oct. 22, 2010, the contents of each of which are hereby incorporated by reference in their entirety into this application.
FIELD OF THE INVENTION
• The present invention is in the field of drug response and disease risk, particularly genetic polymorphisms that are associated with response to statins, especially for the prevention or treatment of cardiovascular diseases (CVD) such as coronary heart disease (CHD) (which includes coronary events such as myocardial infarction (MI)) and cerebrovascular events (such as stroke). In particular, the present invention relates to specific single nucleotide polymorphisms (SNPs) in the human genome, and their association with variability in responsiveness to statin treatment (including preventive treatment) in reducing CVD risk between different individuals. These SNPs are also useful for assessing an individual's risk for developing CVD. The SNPs disclosed herein can be used, for example, as targets for diagnostic reagents and for the development of therapeutic agents. In particular, the SNPs of the present invention are useful for such uses as predicting an individual's response to therapeutic agents such as evaluating the likelihood of an individual differentially responding positively to statins, particularly for the treatment or prevention of CVD (particularly CHD such as MI, as well as stroke), identifying an individual who has an increased or decreased risk of developing CVD (particularly CHD such as MI, as well as stroke), for early detection of the disease, for providing clinically important information for the prevention and/or treatment of CVD, for predicting recurrence of CVD, and for screening and selecting therapeutic agents. Methods, assays, kits, and reagents for detecting the presence of these polymorphisms and their encoded products are provided.
BACKGROUND OF THE INVENTION
• The present invention relates to SNPs that are associated with variability between individuals in their response to statins, particularly for the prevention or treatment of cardiovascular disease (CVD), which includes coronary heart disease (CHD) (which further includes myocardial infarction (MI) and other coronary events) and cerebrovascular events such as stroke and transient ischemic attack (TIA). These SNPs are also useful for determining an individual's risk for developing CVD, particularly CHD (including coronary events such as MI) as well as cerebrovascular events (such as stroke and TIA).
• HMG-CoA Reductase Inhibitors (Statins)
• HMG-CoA reductase inhibitors (statins) are used for the treatment and prevention of CVD, particularly CHD (including coronary events such as MI) and cerebrovascular events (such as stroke). Reduction of MI, stroke, and other coronary and cerebrovascular events and total mortality by treatment with HMG-CoA reductase inhibitors has been demonstrated in a number of randomized, double-blinded, placebo-controlled prospective trials (D. D. Waters, Clin Cardiol 24(8 Suppl):III3-7 (2001); B. K. Singh and J. L. Mehta, Curr Opin Cardiol 17(5):503-11 (2002)). These drugs are thought to typically have their primary effect through the inhibition of hepatic cholesterol synthesis, thereby upregulating LDL receptors in the liver. The resultant increase in LDL catabolism results in decreased circulating LDL, a major risk factor for cardiovascular disease.
• Examples of statins include, but are not limited to, atorvastatin (Lipitor®), rosuvastatin (Crestor®), pravastatin (Pravachol®), simvastatin (Zocor®), fluvastatin (Lescol®), and lovastatin (Mevacor®), as well as combination therapies that include a statin such as simvastatin+ezetimibe (Vytorin®), lovastatin+niacin (Advicor®), atorvastatin+amlodipine besylate (Caduet®), and simvastatin+niacin (Simcor®).
• Statins can be divided into two types according to their physicochemical and pharmacokinetic properties. Statins such as atorvastatin, simvastatin, lovastatin, and cerivastatin are lipophilic in nature and, as such, diffuse across membranes and thus are highly cell permeable. Hydrophilic statins such as pravastatin are more polar, such that they require specific cell surface transporters for cellular uptake. K. Ziegler and W. Stunkel, Biochim Biophys Acta 1139(3):203-9 (1992); M. Yamazaki et al., Am J Physiol 264(1 Pt 1):G36-44 (1993); T. Komai et al., Biochem Pharmacol 43(4):667-70 (1992). The latter statins utilizes a transporter, OATP2, whose tissue distribution is confined to the liver and, therefore, they are relatively hepato-specific inhibitors. B. Hsiang et al., J Biol Chem 274(52):37161-37168 (1999). The former statins, not requiring specific transport mechanisms, are available to all cells and they can directly impact a much broader spectrum of cells and tissues. These differences in properties may influence the spectrum of activities that each statin possesses. Pravastatin, for instance, has a low myopathic potential in animal models and myocyte cultures compared to lipophilic statins. B. A. Masters et al., Toxicol Appl Pharmacol 131(1):163-174 (1995); K. Nakahara et al., Toxicol Appl Pharmacol 152(1):99-106 (1998); J. C. Reijneveld et al., Pediatr Res 39(6):1028-1035 (1996). Statins are reviewed in Vaughan et al., “Update on Statins: 2003”, Circulation 2004; 110; 886-892.
• Evidence from gene association studies is accumulating to indicate that responses to drugs are, indeed, at least partly under genetic control. As such, pharmacogenetics—the study of variability in drug responses attributed to hereditary factors in different populations—may significantly assist in providing answers toward meeting this challenge. A. D. Roses, Nature 405(6788):857-865 (2000); V. Mooser et al., J Thromb Haemost 1(7):1398-1402 (2003); L. M. Humma and S. G. Terra, Am J Health Syst Pharm 59(13):1241-1252 (2002). Associations have been reported between specific genotypes, as defined by SNPs and other genetic sequence variations, and specific responses to cardiovascular drugs. For example, a polymorphism in the KIF6 gene is associated with response to statin treatment (Iakoubova et al., “Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):449-55; Iakoubova et al., “Association of the 719Arg variant of KIF6 with both increased risk of coronary events and with greater response to statin therapy”, J Am Coll Cardiol. 2008 Jun. 3; 51(22):2195; Iakoubova et al., “KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study”, Eur J Cardiovasc Prev Rehabil. 2010 Apr. 20; and Shiffman et al., “Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial”, Am J Cardiol. 2010 May 1; 105(9):1300-5).
• There is a need for genetic markers that can be used to predict an individual's responsiveness to statins. For example, there is a growing need to better identify people who have a high chance of benefiting from statins, and those who have a low risk of developing side-effects. For example, severe myopathies represent a significant risk for a low percentage of the patient population, and this may be a particular concern for patients who are treated more aggressively with statins. Furthermore, different patients may have the same the risk for adverse events but are more likely to benefit from a drug (such as statins) and this may justify use of the drug in those individuals who are more likely to benefit. Similarly, in individuals who are less likely to benefit from a drug but are at risk for adverse events, use of the drug in these individuals can be de-prioritized or delayed.
• An example of a large trial which analyzed the benefits of statin treatment for reducing the risk of CVD in a large population was the JUPITER Study (described in Ridker et al., “Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein”, N Engl J Med. 2008 Nov. 20; 359(21):2195-207), which demonstrated that rosuvastatin (Crestor®) significantly reduced the incidence of major cardiovascular events (including MI, stroke, arterial revascularization, hospitalization for unstable angina, and death from cardiovascular causes) in a study of 17,802 individuals.
• The benefits of using statins for stroke is also described in O'Regan et al., “Statin therapy in stroke prevention: a meta-analysis involving 121,000 patients”, Am J Med. 2008 January; 121(1):24-33 and Everett et al., “Rosuvastatin in the prevention of stroke among men and women with elevated levels of C-reactive protein: justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER)”, Circulation. 2010 Jan. 5; 121(1):143-50.
• Cardiovascular Disease (CVD), Including Coronary Heart Disease (CHD) and Stroke
• Cardiovascular disease (CVD) includes coronary heart disease (CHD) (which further includes myocardial infarction (MI) and other coronary events) and cerebrovascular events such as stroke and transient ischemic attack (TIA).
• Coronary heart disease (CHD) is defined herein as encompassing MI (fatal or non-fatal) and other coronary events, death from coronary disease, angina pectoris (particularly unstable angina), and coronary stenosis. The presence of CHD may be indicated by the occurrence of medical interventions such as coronary revascularization, which can include percutaneous transluminal coronary angioplasty (PTCA), coronary stent placement, and coronary artery bypass graft (CABG). Cardiovascular disease (CVD) is defined herein as encompassing CHD as well as cerebrovascular events such as stroke and transient ischemic attack (TIA).
• Myocardial Infarction (MI)
• Myocardial infarction (MI) is encompassed within CHD. MI, also referred to as a “heart attack”, is the most common cause of mortality in developed countries. The incidence of MI is still high despite currently available preventive measures and therapeutic intervention. More than 1,500,000 people in the U.S. suffer acute MI each year, many without seeking help due to unrecognized MI, and one third of these people die. The lifetime risk of coronary artery disease events at age 40 is 42.4% for men, nearly one in two, and 24.9% for women, or one in four (D. M. Lloyd-Jones, Lancet 353:89-92 (1999)).
• MI is a multifactorial disease that involves atherogenesis, thrombus formation and propagation. Thrombosis can result in complete or partial occlusion of coronary arteries. The luminal narrowing or blockage of coronary arteries reduces oxygen and nutrient supply to the cardiac muscle (cardiac ischemia), leading to myocardial necrosis and/or stunning. MI, unstable angina, and sudden ischemic death are clinical manifestations of cardiac muscle damage. All three endpoints are part of acute coronary syndrome since the underlying mechanisms of acute complications of atherosclerosis are considered to be the same.
• Atherogenesis, the first step of pathogenesis of MI, is an interaction between blood elements, mechanical forces, disturbed blood flow, and vessel wall abnormality that results in plaque accumulation. An unstable (vulnerable) plaque is an underlying cause of arterial thrombotic events and MI. A vulnerable plaque is a plaque, often not stenotic, that has a high likelihood of becoming disrupted or eroded, thus forming a thrombogenic focus. The “vulnerability” of an individual to MI may be due to vulnerable plaque, blood vulnerability (hypercoagulation, hypothrombolysis), and heart vulnerability (sensitivity of the heart to ischemia or propensity for arrhythmia). Recurrent myocardial infarction (RMI) can generally be viewed as a severe form of MI progression caused by multiple vulnerable plaques that are able to undergo pre-rupture or a pre-erosive state, coupled with extreme blood coagulability.
• The current diagnosis of MI with presentation (rather than to predict if MI is likely to occur in the future) is based on the levels of troponin I or T that indicate the cardiac muscle progressive necrosis, impaired electrocardiogram (ECG), and detection of abnormal ventricular wall motion or angiographic data (the presence of acute thrombi). However, due to the asymptomatic nature of 25% of acute MIs (absence of atypical chest pain, low ECG sensitivity), a significant portion of MIs are not diagnosed and therefore not treated appropriately (e.g., prevention of recurrent MIs).
• MI risk assessment and prognosis is currently done using classic risk factors or the recently introduced Framingham Risk Index. Both of these assessments put a significant weight on LDL levels to justify preventive treatment. However, it is well established that half of all MIs occur in individuals without overt hyperlipidemia.
• Other emerging risk factors of MI are inflammatory biomarkers such as C-reactive protein (CRP), ICAM-1, SAA, TNF a, homocysteine, impaired fasting glucose, new lipid markers (ox LDL, Lp-a, MAD-LDL, etc.) and pro-thrombotic factors (fibrinogen, PAI-1). These markers have significant limitations such as low specificity and low positive predictive value, and the need for multiple reference intervals to be used for different groups of people (e.g., males-females, smokers-non smokers, hormone replacement therapy users, different age groups). These limitations diminish the utility of such markers as independent prognostic markers for MI screening.
• Genetics plays an important role in MI risk. Families with a positive family history of MI account for 14% of the general population, 72% of premature MIs, and 48% of all MIs (R. R. Williams, Am J Cardiology 87:129 (2001)). Associations have been reported between genetic polymorphisms and MI risk. For example, polymorphism in the KIF6, LPA, and other genes and chromosomal regions are associated with MI risk (Shiffman et al., “Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study”, Arterioscler Thromb Vasc Biol. 2008 January; 28(1):173-9; Bare et al., “Five common gene variants identify elevated genetic risk for coronary heart disease”, Genet Med. 2007 October; 9(10):682-9; Iakoubova et al., “Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):435-43; and Shiffman et al., “A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):444-8.
• Genetic markers such as single nucleotide polymorphisms (SNPs) are preferable to other types of biomarkers. Genetic markers that are prognostic for MI can be genotyped early in life and could predict individual response to various risk factors. The combination of serum protein levels and genetic predisposition revealed by genetic analysis of susceptibility genes can provide an integrated assessment of the interaction between genotypes and environmental factors, resulting in synergistically increased prognostic value of diagnostic tests.
• Thus, there is an urgent need for novel genetic markers that are predictive of predisposition to CHD such as MI, particularly for individuals who are unrecognized as having a predisposition to MI. Such genetic markers may enable prognosis of MI in much larger populations compared with the populations that can currently be evaluated by using existing risk factors and biomarkers. The availability of a genetic test may allow, for example, appropriate preventive treatments for acute coronary events to be provided for susceptible individuals (such preventive treatments may include, for example, statin treatments and statin dose escalation, as well as changes to modifiable risk factors), lowering of the thresholds for ECG and angiography testing, and allow adequate monitoring of informative biomarkers. Moreover, the discovery of genetic markers associated with MI can provide novel targets for therapeutic intervention or preventive treatments of MI, and enable the development of new therapeutic agents for treating or preventing MI and other cardiovascular disorders.
• Furthermore, novel genetic markers that are predictive of predisposition to MI can be particularly useful for identifying individuals who are at risk for early-onset MI. “Early-onset MI” may be defined as MI in men who are less than 55 years of age and women who are less than 65 years of age (K. O. Akosah et al., “Preventing myocardial infarction in the young adult in the first place: How do the National Cholesterol Education Panel III guidelines perform?” JACC 41(9):1475-1479 (2003)). Individuals who experience early-onset MI may not be effectively identified by current cholesterol treatment guidelines, such as those suggested by the National Cholesterol Education Program. In one study, for example, a significant number of individuals who suffered MI at an earlier age (≦50 years) were shown to have LDL cholesterol below 100 mg/dl (K. O. Akosah et al., “Myocardial infarction in young adults with low-density lipoprotein cholesterol levels less than or equal to 100 mg/dl. Clinical profile and 1-year outcomes.” Chest 120:1953-1958 (2001)). Because risk for MI can be reduced by lifestyle changes and by treatment of modifiable risk factors, better methods to identify individuals at risk for early-onset MI could be useful for making preventive treatment decisions, especially considering that these patients may not be identified for medical management by conventional treatment guidelines. Genetic markers for risk of early-onset MI could potentially be incorporated into individual risk assessment protocols, as they have the advantage of being easily detected at any age.
• Stroke
• Stroke is a prevalent and serious cerebrovascular disease. It affects 4.7 million individuals in the United States, with 500,000 first attacks and 200,000 recurrent cases yearly. Approximately one in four men and one in five women aged 45 years will have a stroke if they live to their 85th year. About 25% of those who have a stroke die within a year. Stroke is the third leading cause of mortality in the United States and is responsible for 170,000 deaths a year. Among those who survive a stroke attack, 30 to 50% do not regain functional independence. Stroke therefore is the most common cause of disability and the second leading cause of dementia (Heart Disease and Stroke Statistics—2004 Update, American Heart Association).
• Stroke occurs when an artery bringing oxygen and nutrients to the brain either ruptures, causing hemorrhagic stroke, or gets occluded, causing ischemic stroke. Ischemic stroke can be caused by thrombi formation at the site of an atherosclerotic plaque rupture (this type of ischemic stroke is interchangeably referred to as thrombotic or atherothrombotic stroke) or by emboli (clots) that have travelled from another part of the vasculature (this type of ischemic stroke is referred to as embolic stroke), often from the heart (this type of embolic stroke may be referred to as cardioembolic stroke). In both ischemic and hemorrhagic stroke, a cascade of cellular changes due to ischemia or increased cranial pressure leads to injuries or death of the brain cells. In the United States, the majority (about 80-90%) of stroke cases are ischemic (Rathore, et al., Stroke 33:2718-2721 ((2002)), including 30% large-vessel thrombotic (also referred to as large-vessel occlusive disease), 20% small-vessel thrombotic (also referred to as small-vessel occlusive disease), and 30% embolic or cardiogenic (caused by a clot originating from elsewhere in the body, e.g., from blood pooling due to atrial fibrillation, or from carotid artery stenosis). The ischemic form of stroke results from obstruction of blood flow in cerebral blood vessels, and it shares common pathological etiology with atherosclerosis and thrombosis.
• About 10-20% of stroke cases are of the hemorrhagic type (Rathore, et al., Stroke 33:2718-2721 ((2002)), involving bleeding within or around the brain. Bleeding within the brain is known as cerebral hemorrhage, which is often linked to high blood pressure. Bleeding into the meninges surrounding the brain is known as a subarachnoid hemorrhage, which could be caused by a ruptured cerebral aneurysm, an arteriovenous malformation, or a head injury. The hemorrhagic stroke, although less prevalent, poses a greater danger. Whereas about 8% of ischemic stroke cases result in death within 30 days, about 38% of hemorrhagic stroke cases result in death within the same time period (Collins, et al., J. Clin. Epidemiol. 56:81-87 (2003)).
• Transient ischemic attack (TIA) is a condition related to stroke. According to the National Institute of Neurological Disorders and Stroke (NINDS), “A transient ischemic attack (TIA) is a transient stroke that lasts only a few minutes. It occurs when the blood supply to part of the brain is briefly interrupted. TIA symptoms, which usually occur suddenly, are similar to those of stroke but do not last as long. Most symptoms of a TIA disappear within an hour, although they may persist for up to 24 hours. Symptoms can include: numbness or weakness in the face, arm, or leg, especially on one side of the body; confusion or difficulty in talking or understanding speech; trouble seeing in one or both eyes; and difficulty with walking, dizziness, or loss of balance and coordination”. NINDS further states that, “TIAs are often warning signs that a person is at risk for a more serious and debilitating stroke. About one-third of those who have a TIA will have an acute stroke some time in the future. Many strokes can be prevented by heeding the warning signs of TIAs and treating underlying risk factors.”
• Known risk factors for stroke or TIA can be divided into modifiable and non-modifiable risk factors. Older age, male sex, black or Hispanic ethnicity, and family history of stroke are non-modifiable risk factors. Modifiable risk factors include hypertension, smoking, increased insulin levels, asymptomatic carotid disease, cardiac vessel disease, and hyperlipidemia.
• Multiple reports based on twin studies (Brass et al., Stroke. 1992; 23:221-223 and Bak et al., Stroke. 2002; 33:769-774) and family studies (Welin L, et al. N Engl J Med. 1987; 317:521-526 and Jousilahti et al., Stroke. 1997; 28:1361-136) have shown that genetics contributes to risk of stroke independently of traditional risk factors. A number of genetic markers have been reported to be associated with stroke. For example, SNPs in the 4q25 region were reported to be associated with stroke (Gretarsdottir et al., “Risk variants for atrial fibrillation on chromosome 4q25 associate with ischemic stroke”, Ann Neurol. 2008; 64:402-409) and with atrial fibrillation (AF) (Gudbjartsson et al., “Variants conferring risk of atrial fibrillation on chromosome 4q25”, Nature. 2007; 448:353-357), SNPs in the 16q22 region (Gudbjartsson et al., “A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke”, Nat Genet. 2009; 41:876-878) and in the 9p21 region were found to be associated with noncardioembolic or atherothrombotic stroke (Luke et al., “Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry”, Cerebrovasc Dis. 2009; 28:499-504 and Gschwendtner et al., “Sequence variants on chromosome 9p21.3 confer risk for atherosclerotic stroke”, Ann Neurol. 2009; 65:531-539), and variants in the 12p13 region were associated with stroke in general and with atherothrombotic stroke in particular (Ikram et al., “Genomewide association studies of stroke”, N Engl J Med. 2009; 360:1718-1728).
• The acute nature of stroke leaves physicians with little time to prevent or lessen the devastation of brain damage. Strategies to diminish the impact of stroke include prevention and treatment with thrombolytic and, possibly, neuroprotective agents. The success of preventive measures will depend on the identification of risk factors in individual patients and means to modulate their impact.
• Although some risk factors for stroke or TIA are not modifiable, such as age and family history, other underlying pathology or risk factors of stroke or TIA such as atherosclerosis, hypertension, smoking, diabetes, aneurysm, and atrial fibrillation, are chronic and amenable to effective life-style changes, pharmacological interventions, as well as surgical treatments. Early recognition of patients with informative risk factors, and especially those with a family history, using a non-invasive test of genetic markers associated with stroke can enable physicians to target the highest risk individuals for aggressive risk reduction.
• Thus, there is a need for the identification of genetic markers that are predictive of an individual's predisposition to stroke or TIA and other vascular diseases. Furthermore, the identification of genetic markers which are useful for identifying individuals who are at an increased risk of having a stroke may lead to, for example, better preventive and therapeutic strategies, economic models, and health care policy decisions.
• Single Nucleotide Polymorphisms (SNPs)
• The genomes of all organisms undergo spontaneous mutations in the course of their continuing evolution, generating variant forms of progenitor genetic sequences. Gusella, Ann Rev Biochem 55:831-854 (1986). A variant form may confer an evolutionary advantage or disadvantage relative to a progenitor form or may be neutral. In some instances, a variant form confers an evolutionary advantage to individual members of a species and is eventually incorporated into the DNA of many or most members of the species and effectively becomes the progenitor form. Additionally, the effects of a variant form may be both beneficial and detrimental, depending on the environment. For example, a heterozygous sickle cell mutation confers resistance to malaria, but a homozygous sickle cell mutation is usually lethal. In many cases, both progenitor and variant forms survive and co-exist in a species population. The coexistence of multiple forms of a genetic sequence segregating at appreciable frequencies is defined as a genetic polymorphism, which includes single nucleotide polymorphisms (SNPs).
• Approximately 90% of all genetic polymorphisms in the human genome are SNPs. SNPs are single base positions in DNA at which different alleles, or alternative nucleotides, exist in a population. The SNP position (interchangeably referred to herein as SNP, SNP site, SNP locus, SNP marker, or marker) is usually preceded by and followed by highly conserved sequences (e.g., sequences that vary in less than 1/100 or 1/1000 members of the populations). An individual may be homozygous or heterozygous for an allele at each SNP position. A SNP can, in some instances, be referred to as a “cSNP” to denote that the nucleotide sequence containing the SNP is an amino acid coding sequence.
• A SNP may arise from a substitution of one nucleotide for another at the polymorphic site. Substitutions can be transitions or transversions. A transition is the replacement of one purine nucleotide by another purine nucleotide, or one pyrimidine by another pyrimidine. A transversion is the replacement of a purine by a pyrimidine, or vice versa. A SNP may also be a single base insertion or deletion variant referred to as an “indel.” Weber et al., “Human diallelic insertion/deletion polymorphisms,” Am J Hum Genet 71(4):854-62 (October 2002).
• A synonymous codon change, or silent mutation/SNP (terms such as “SNP”, “polymorphism”, “mutation”, “mutant”, “variation”, and “variant” are used herein interchangeably), is one that does not result in a change of amino acid due to the degeneracy of the genetic code. A substitution that changes a codon coding for one amino acid to a codon coding for a different amino acid (i.e., a non-synonymous codon change) is referred to as a missense mutation. A nonsense mutation results in a type of non-synonymous codon change in which a stop codon is formed, thereby leading to premature termination of a polypeptide chain and a truncated protein. A read-through mutation is another type of non-synonymous codon change that causes the destruction of a stop codon, thereby resulting in an extended polypeptide product. While SNPs can be bi-, tri-, or tetra-allelic, the vast majority of SNPs are bi-allelic, and are thus often referred to as “bi-allelic markers,” or “di-allelic markers.”
• As used herein, references to SNPs and SNP genotypes include individual SNPs and/or haplotypes, which are groups of SNPs that are generally inherited together. Haplotypes can have stronger correlations with diseases or other phenotypic effects compared with individual SNPs, and therefore may provide increased diagnostic accuracy in some cases. Stephens et al., Science 293:489-493 (July 2001).
• Causative SNPs are those SNPs that produce alterations in gene expression or in the expression, structure, and/or function of a gene product, and therefore are most predictive of a possible clinical phenotype. One such class includes SNPs falling within regions of genes encoding a polypeptide product, i.e. cSNPs. These SNPs may result in an alteration of the amino acid sequence of the polypeptide product (i.e., non-synonymous codon changes) and give rise to the expression of a defective or other variant protein. Furthermore, in the case of nonsense mutations, a SNP may lead to premature termination of a polypeptide product. Such variant products can result in a pathological condition, e.g., genetic disease. Examples of genes in which a SNP within a coding sequence causes a genetic disease include sickle cell anemia and cystic fibrosis.
• Causative SNPs do not necessarily have to occur in coding regions; causative SNPs can occur in, for example, any genetic region that can ultimately affect the expression, structure, and/or activity of the protein encoded by a nucleic acid. Such genetic regions include, for example, those involved in transcription, such as SNPs in transcription factor binding domains, SNPs in promoter regions, in areas involved in transcript processing, such as SNPs at intron-exon boundaries that may cause defective splicing, or SNPs in mRNA processing signal sequences such as polyadenylation signal regions. Some SNPs that are not causative SNPs nevertheless are in close association with, and therefore segregate with, a disease-causing sequence. In this situation, the presence of a SNP correlates with the presence of, or predisposition to, or an increased risk in developing the disease. These SNPs, although not causative, are nonetheless also useful for diagnostics, disease predisposition screening, and other uses.
• An association study of a SNP and a specific disorder involves determining the presence or frequency of the SNP allele in biological samples from individuals with the disorder of interest, such as CVD, and comparing the information to that of controls (i.e., individuals who do not have the disorder; controls may be also referred to as “healthy” or “normal” individuals) who are preferably of similar age and race. The appropriate selection of patients and controls is important to the success of SNP association studies. Therefore, a pool of individuals with well-characterized phenotypes is extremely desirable.
• A SNP may be screened in diseased tissue samples or any biological sample obtained from a diseased individual, and compared to control samples, and selected for its increased (or decreased) occurrence in a specific pathological condition, such as pathologies related to CVD and in particular, CHD (e.g., MI). Once a statistically significant association is established between one or more SNP(s) and a pathological condition (or other phenotype) of interest, then the region around the SNP can optionally be thoroughly screened to identify the causative genetic locus/sequence(s) (e.g., causative SNP/mutation, gene, regulatory region, etc.) that influences the pathological condition or phenotype. Association studies may be conducted within the general population and are not limited to studies performed on related individuals in affected families (linkage studies).
• Clinical trials have shown that patient response to treatment with pharmaceuticals is often heterogeneous. There is a continuing need to improve pharmaceutical agent design and therapy. In that regard, SNPs can be used to identify patients most suited to therapy with particular pharmaceutical agents (this is often termed “pharmacogenomics”). Similarly, SNPs can be used to exclude patients from certain treatment due to the patient's increased likelihood of developing toxic side effects or their likelihood of not responding to the treatment. Pharmacogenomics can also be used in pharmaceutical research to assist the drug development and selection process. Linder et al., Clinical Chemistry 43:254 (1997); Marshall, Nature Biotechnology 15:1249 (1997); International Patent Application WO 97/40462, Spectra Biomedical; and Schafer et al., Nature Biotechnology 16:3 (1998).
SUMMARY OF THE INVENTION
• Exemplary embodiments of the present invention relate to the identification of SNPs, as well as unique combinations of such SNPs and haplotypes of SNPs, that are associated with variability between individuals in their response to statins, particularly for the prevention or treatment of cardiovascular disease (CVD), which includes coronary heart disease (CHD) (which further includes myocardial infarction (MI) and other coronary events) and cerebrovascular events such as stroke. These SNPs are also useful for determining an individual's risk for developing CVD, particularly CHD (including coronary events such as MI) as well as cerebrovascular events such as stroke. The polymorphisms disclosed herein are directly useful as targets for the design of diagnostic and prognostic reagents and the development of therapeutic and preventive agents for use in the diagnosis, prognosis, treatment, and/or prevention of CVD (particularly CHD, such as MI), as well as for predicting a patient's response to therapeutic agents such as statins, particularly for the treatment or prevention of CVD (particularly CHD, such as MI).
• Based on the identification of SNPs associated with variability between individuals in their response to statins, particularly for reducing the risk of CVD such as CHD (e.g., MI) and stroke, exemplary embodiments of the present invention also provide methods of detecting these variants as well as the design and preparation of detection reagents needed to accomplish this task. The invention specifically provides, for example, SNPs associated with responsiveness to statin treatment, isolated nucleic acid molecules (including DNA and RNA molecules) containing these SNPs, variant proteins encoded by nucleic acid molecules containing such SNPs, antibodies to the encoded variant proteins, computer-based and data storage systems containing the novel SNP information, methods of detecting these SNPs in a test sample, methods of identifying individuals who have an altered (i.e., increased or decreased) risk of developing CVD (such as CHD (e.g., MI) or stroke), methods for determining the risk of an individual for recurring CVD (e.g., recurrent MI), methods of treating an individual who has an increased risk for CVD and/or increased likelihood of responding to statin treatment, and methods for identifying individuals (e.g., determining a particular individual's likelihood) who have an altered (i.e., increased or decreased) likelihood of responding to drug treatment (especially statin treatment), particularly drug treatment of CVD (e.g., prevention or treatment of CHD such as MI), based on the presence or absence of one or more particular nucleotides (alleles) at one or more SNP sites disclosed herein or the detection of one or more encoded variant products (e.g., variant mRNA transcripts or variant proteins), methods of screening for compounds useful in the treatment or prevention of CVD, compounds identified by these methods, methods of treating or preventing CVD, etc.
• Exemplary embodiments of the present invention further provide methods for selecting or formulating a treatment regimen (e.g., methods for determining whether or not to administer statin treatment to an individual having CVD, or who is at risk for developing CVD in the future, or who has previously had CVD, methods for selecting a particular statin-based treatment regimen such as dosage and frequency of administration of statin, or a particular form/type of statin such as a particular pharmaceutical formulation or statin compound, methods for administering (either in addition to or instead of a statin) an alternative, non-statin-based treatment, such as niacin, fibrates, or ezetimibe (e.g., Zetia® or Ezetrol®), to individuals who are predicted to be unlikely to respond positively to statin treatment, etc.), and methods for determining the likelihood of experiencing toxicity or other undesirable side effects from statin treatment, etc. Various embodiments of the present invention also provide methods for selecting individuals to whom a statin or other therapeutic will be administered based on the individual's genotype, and methods for selecting individuals for a clinical trial of a statin or other therapeutic agent based on the genotypes of the individuals (e.g., selecting individuals to participate in the trial who are most likely to respond positively from the statin treatment and/or excluding individuals from the trial who are unlikely to respond positively from the statin treatment based on their SNP genotype(s), or selecting individuals who are unlikely to respond positively to statins based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them). Further embodiments of the present invention provide methods for reducing an individual's risk of developing CVD (such as CHD (e.g., MI) or stroke) using statin treatment, including preventing recurring CVD (e.g., recurrent MI) using statin treatment, when said individual carries one or more SNPs identified herein as being associated with statin response.
• Tables 1 and 2 provides gene information, references to the identification of transcript sequences (SEQ ID NOS:1-51), encoded amino acid sequences (SEQ ID NOS:52-102), genomic sequences (SEQ ID NOS:177-622), transcript-based context sequences (SEQ ID NOS:103-176) and genomic-based context sequences (SEQ ID NOS:623-3661) that contain the SNPs of the present application, and extensive SNP information that includes observed alleles, allele frequencies, populations/ethnic groups in which alleles have been observed, information about the type of SNP and corresponding functional effect, and, for cSNPs, information about the encoded polypeptide product. The actual transcript sequences (SEQ ID NOS:1-51), amino acid sequences (SEQ ID NOS:52-102), genomic sequences (SEQ ID NOS:177-622), transcript-based SNP context sequences (SEQ ID NOS:103-176), and genomic-based SNP context sequences (SEQ ID NOS:623-3661) are provided in the Sequence Listing.
• In certain exemplary embodiments, the invention provides methods for identifying an individual who has an altered likelihood of responding to statin treatment or an altered risk for developing CVD, particularly CHD or stroke (including, for example, a first incidence and/or a recurrence of the disease, such as primary or recurrent MI), in which the method comprises detecting a single nucleotide polymorphism (SNP) in any one of the nucleotide sequences of SEQ ID NOS:1-51, SEQ ID NOS:103-176, SEQ ID NOS:177-622, and SEQ ID NOS:623-3661 in said individual's nucleic acids, wherein the SNP is specified in Table 1 and/or Table 2, and the presence of the SNP is indicative of an altered response to statin treatment of an altered risk for CVD in said individual. In certain embodiments, the CVD is CHD, particularly MI. In certain other embodiments, the CVD is stroke. In certain exemplary embodiments of the invention, SNPs that occur naturally in the human genome are provided within isolated nucleic acid molecules. These SNPs are associated with response to statin treatment thereby reducing the risk of CVD, such as CHD (e.g., MI) or stroke, such that they can have a variety of uses in the diagnosis, prognosis, treatment, and/or prevention of CVD, and particularly in the treatment or prevention of CVD using statins. In certain embodiments, a nucleic acid of the invention is an amplified polynucleotide, which is produced by amplification of a SNP-containing nucleic acid template. In another embodiment, the invention provides for a variant protein that is encoded by a nucleic acid molecule containing a SNP disclosed herein.
• In further embodiments of the invention, reagents for detecting a SNP in the context of its naturally-occurring flanking nucleotide sequences (which can be, e.g., either DNA or mRNA) are provided. In particular, such a reagent may be in the form of, for example, a hybridization probe or an amplification primer that is useful in the specific detection of a SNP of interest. In an alternative embodiment, a protein detection reagent is used to detect a variant protein that is encoded by a nucleic acid molecule containing a SNP disclosed herein. A preferred embodiment of a protein detection reagent is an antibody or an antigen-reactive antibody fragment. Various embodiments of the invention also provide kits comprising SNP detection reagents, and methods for detecting the SNPs disclosed herein by employing the SNP detection reagents. An exemplary embodiment of the present invention provides a kit comprising a SNP detection reagent for use in determining whether a human's risk for CVD is reduced by treatment with statins based upon the presence or absence of a particular allele of one or more SNPs disclosed herein.
• In various embodiments, the present invention provides methods for evaluating whether an individual is likely (or unlikely) to respond to statin treatment (i.e., benefit from statin treatment)), particularly statin treatment for reducing the risk of CVD, particularly CHD (such as MI) or stroke, by detecting the presence or absence of one or more SNP alleles disclosed herein. The present invention also provides methods of identifying an individual having an increased or decreased risk of developing CVD, such as CHD (e.g., MI) or stroke, by detecting the presence or absence of one or more SNP alleles disclosed herein.
• In certain embodiments, the presence of a statin response allele disclosed herein in Tables 4-22 (an allele associated with increased response to statin treatment for reducing CVD or CHD risk) is detected and indicates that an individual has an increased risk for developing CVD, such as CHD (e.g., MI) or stroke. In these embodiments, in which the same allele is associated with both increased risk for developing CVD and increased response to statin treatment (i.e., the same allele is both a risk and a response allele), this increased risk for developing CVD can be reduced by administering statin treatment to an individual having the allele.
• The nucleic acid molecules of the invention can be inserted in an expression vector, such as to produce a variant protein in a host cell. Thus, the present invention also provides for a vector comprising a SNP-containing nucleic acid molecule, genetically-engineered host cells containing the vector, and methods for expressing a recombinant variant protein using such host cells. In another specific embodiment, the host cells, SNP-containing nucleic acid molecules, and/or variant proteins can be used as targets in a method for screening and identifying therapeutic agents or pharmaceutical compounds useful in the treatment or prevention of CVD, such as CHD (e.g., MI) or stroke.
• An aspect of this invention is a method for treating or preventing CVD such as CHD or stroke (including, for example, a first occurrence and/or a recurrence of the disease, such as primary or recurrent MI), in a human subject wherein said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1 and 2, which method comprises administering to said human subject a therapeutically or prophylactically effective amount of one or more agents counteracting the effects of the disease, such as by inhibiting (or stimulating) the activity of a gene, transcript, and/or encoded protein identified in Tables 1 and 2.
• Another aspect of this invention is a method for identifying an agent useful in therapeutically or prophylactically treating CVD (particularly CHD or stroke), in a human subject wherein said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1 and 2, which method comprises contacting the gene, transcript, or encoded protein with a candidate agent under conditions suitable to allow formation of a binding complex between the gene, transcript, or encoded protein and the candidate agent and detecting the formation of the binding complex, wherein the presence of the complex identifies said agent.
• Another aspect of this invention is a method for treating or preventing CVD such as CHD (e.g., MI) or stroke, in a human subject, in which the method comprises:
• (i) determining that said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1 and 2, and
• (ii) administering to said subject a therapeutically or prophylactically effective amount of one or more agents counteracting the effects of the disease, such as statins.
• Another aspect of the invention is a method for identifying a human who is likely to benefit from statin treatment, in which the method comprises detecting an allele of one or more SNPs disclosed herein in said human's nucleic acids, wherein the presence of the allele indicates that said human is likely to benefit from statin treatment.
• Another aspect of the invention is a method for identifying a human who is likely to benefit from statin treatment, in which the method comprises detecting an allele of one or more SNPs that are in LD with one or more SNPs disclosed herein in said human's nucleic acids, wherein the presence of the allele of the LD SNP indicates that said human is likely to benefit from statin treatment.
• Many other uses and advantages of the present invention will be apparent to those skilled in the art upon review of the detailed description of the exemplary embodiments herein. Solely for clarity of discussion, the invention is described in the sections below by way of non-limiting examples.
Description of the Text (ASCII) Files Submitted Electronically Via EFS-Web
• The following three text (ASCII) files are submitted electronically via EFS-Web as part of the instant application:
• 1) File SEQLIST_CD000027ORD.txt provides the Sequence Listing. The Sequence Listing provides the transcript sequences (SEQ ID NOS:1-51) and protein sequences (SEQ ID NOS:52-102) as referred to in Table 1, and genomic sequences (SEQ ID NOS:177-622) as referred to in Table 2, for each gene (or genomic region for intergenic SNPs) that contains one or more statin response-associated SNPs of the present invention. Also provided in the Sequence Listing are context sequences flanking each SNP, including both transcript-based context sequences as referred to in Table 1 (SEQ ID NOS:103-176) and genomic-based context sequences as referred to in Table 2 (SEQ ID NOS:623-3661). The context sequences generally provide 100 bp upstream (5′) and 100 bp downstream (3′) of each SNP, with the SNP in the middle of the context sequence, for a total of 200 bp of context sequence surrounding each SNP. File SEQLIST_CD000027ORD.txt is 63,960 KB in size, and was created on Apr. 5, 2011.

• LENGTHY TABLES
  The patent application contains a lengthy table section. A copy of the table is available in electronic form from the USPTO web site (http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20160108473A1). An electronic copy of the table will also be available from the USPTO upon request and payment of the fee set forth in 37 CFR 1.19(b)(3).

• 2) File TABLE1_CD000027ORD.txt provides Table 1, which is 78 KB in size and was created on Apr. 6, 2011.
• 3) File TABLE2_CD000027ORD.txt provides Table 2, which is 1,971 KB in size and was created on Apr. 6, 2011.
• These three text files are hereby incorporated by reference pursuant to 37 CFR 1.77(b)(4).
• Description of Table 1 and Table 2
• Table 1 and Table 2 (both submitted electronically via EFS-Web as part of the instant application) disclose the SNP and associated gene/transcript/protein information and sequences for the SNPs disclosed in Tables 4-22, as well as for the LD SNPs disclosed in Table 3. Table 1 is based on transcript and protein sequences, whereas Table 2 is based on genomic sequences.
• For each gene, Table 1 provides a header containing gene, transcript and protein information, followed by a transcript and protein sequence identifier (SEQ ID NO), and then SNP information regarding each SNP found in that gene/transcript including the transcript context sequence. For each gene in Table 2, a header is provided that contains gene and genomic information, followed by a genomic sequence identifier (SEQ ID NO) and then SNP information regarding each SNP found in that gene, including the genomic context sequence.
• Note that SNP markers may be included in both Table 1 and Table 2; Table 1 presents the SNPs relative to their transcript sequences and encoded protein sequences, whereas Table 2 presents the SNPs relative to their genomic sequences. In some instances Table 2 may also include, after the last gene sequence, genomic sequences of one or more intergenic regions, as well as SNP context sequences and other SNP information for any SNPs that lie within these intergenic regions. Additionally, in either Table 1 or 2, a “Related Interrogated SNP” may be listed following a SNP which is determined to be in LD with that interrogated SNP according to the given Power value. SNPs can be readily cross-referenced between all Tables based on their Celera hCV (or, in some instances, hDV) identification numbers and/or public rs identification numbers, and to the Sequence Listing based on their corresponding SEQ ID NOs.
• The gene/transcript/protein information includes:
• • a gene number (1 through n, where n=the total number of genes in the Table),
  • a gene symbol, along with an Entrez gene identification number (Entrez Gene database, National Center for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institutes of Health (NIH))
  • a gene name,
  • an accession number for the transcript (e.g., RefSeq NM number, or a Celera hCT identification number if no RefSeq NM number is available) (Table 1 only),
  • an accession number for the protein (e.g., RefSeq NP number, or a Celera hCP identification number if no RefSeq NP number is available) (Table 1 only),
  • the chromosome number of the chromosome on which the gene is located,
  • an OMIM (“Online Mendelian Inheritance in Man” database, Johns Hopkins University/NCBI) public reference number for the gene, and OMIM information such as alternative gene/protein name(s) and/or symbol(s) in the OMIM entry.
• Note that, due to the presence of alternative splice forms, multiple transcript/protein entries may be provided for a single gene entry in Table 1; i.e., for a single Gene Number, multiple entries may be provided in series that differ in their transcript/protein information and sequences.
• Following the gene/transcript/protein information is a transcript context sequence (Table 1), or a genomic context sequence (Table 2), for each SNP within that gene.
• After the last gene sequence, Table 2 may include additional genomic sequences of intergenic regions (in such instances, these sequences are identified as “Intergenic region:” followed by a numerical identification number), as well as SNP context sequences and other SNP information for any SNPs that lie within each intergenic region (such SNPs are identified as “INTERGENIC” for SNP type).
• Note that the transcript, protein, and transcript-based SNP context sequences are all provided in the Sequence Listing. The transcript-based SNP context sequences are provided in both Table 1 and also in the Sequence Listing. The genomic and genomic-based SNP context sequences are provided in the Sequence Listing. The genomic-based SNP context sequences are provided in both Table 2 and in the Sequence Listing. SEQ ID NOs are indicated in Table 1 for the transcript-based context sequences (SEQ ID NOS:103-176); SEQ ID NOs are indicated in Table 2 for the genomic-based context sequences (SEQ ID NOS:623-3661).
• The SNP information includes:
• • Context sequence (taken from the transcript sequence in Table 1, the genomic sequence in Table 2) with the SNP represented by its IUB code, including 100 bp upstream (5′) of the SNP position plus 100 bp downstream (3′) of the SNP position (the transcript-based SNP context sequences in Table 1 are provided in the Sequence Listing as SEQ ID NOS:103-176; the genomic-based SNP context sequences in Table 2 are provided in the Sequence Listing as SEQ ID NOS:623-3661).
  • Celera hCV internal identification number for the SNP (in some instances, an “hDV” number is given instead of an “hCV” number).
  • The corresponding public identification number for the SNP, the rs number.
  • “SNP Chromosome Position” indicates the nucleotide position of the SNP along the entire sequence of the chromosome as provided in NCBI Genome Build 36.
  • SNP position (nucleotide position of the SNP within the given transcript sequence (Table 1) or within the given genomic sequence (Table 2)).
  • “Related Interrogated SNP” is the interrogated SNP with which the listed SNP is in LD at the given value of Power.
  • SNP source (may include any combination of one or more of the following five codes, depending on which internal sequencing projects and/or public databases the SNP has been observed in: “Applera”=SNP observed during the re-sequencing of genes and regulatory regions of 39 individuals, “Celera”=SNP observed during shotgun sequencing and assembly of the Celera human genome sequence, “Celera Diagnostics”=SNP observed during re-sequencing of nucleic acid samples from individuals who have a disease, “dbSNP”=SNP observed in the dbSNP public database, “HGBASE”=SNP observed in the HGBASE public database, “HGMD”=SNP observed in the Human Gene Mutation Database (HGMD) public database, “HapMap”=SNP observed in the International HapMap Project public database, “CSNP”=SNP observed in an internal Applied Biosystems (Foster City, Calif.) database of coding SNPS (cSNPs).
• Note that multiple “Applera” source entries for a single SNP indicate that the same SNP was covered by multiple overlapping amplification products and the re-sequencing results (e.g., observed allele counts) from each of these amplification products is being provided.
• • Population/allele/allele count information in the format of [population1(first_allele,count|second_allele,count)population2(first_allele,count|second_allele,count) total (first_allele,total count|second_allele,total count)]. The information in this field includes populations/ethnic groups in which particular SNP alleles have been observed (“cau”=Caucasian, “his”=Hispanic, “chn”=Chinese, and “afr”=African-American, “jpn”=Japanese, “ind”=Indian, “mex”=Mexican, “ain”=“American Indian, “cra”=Celera donor, “no_pop”=no population information available), identified SNP alleles, and observed allele counts (within each population group and total allele counts), where available [“−” in the allele field represents a deletion allele of an insertion/deletion (“indel”) polymorphism (in which case the corresponding insertion allele, which may be comprised of one or more nucleotides, is indicated in the allele field on the opposite side of the “|”); “−” in the count field indicates that allele count information is not available]. For certain SNPs from the public dbSNP database, population/ethnic information is indicated as follows (this population information is publicly available in dbSNP): “HISP1”=human individual DNA (anonymized samples) from 23 individuals of self-described HISPANIC heritage; “PAC1”=human individual DNA (anonymized samples) from 24 individuals of self-described PACIFIC RIM heritage; “CAUC1”=human individual DNA (anonymized samples) from 31 individuals of self-described CAUCASIAN heritage; “AFR1”=human individual DNA (anonymized samples) from 24 individuals of self-described AFRICAN/AFRICAN AMERICAN heritage; “P1”=human individual DNA (anonymized samples) from 102 individuals of self-described heritage; “PA130299515”; “SC_12_A”=SANGER 12 DNAs of Asian origin from Corielle cell repositories, 6 of which are male and 6 female; “SC_12_C”=SANGER 12 DNAs of Caucasian origin from Corielle cell repositories from the CEPH/UTAH library, six male and six female; “SC_12_AA”=SANGER 12 DNAs of African-American origin from Corielle cell repositories 6 of which are male and 6 female; “SC_95_C”=SANGER 95 DNAs of Caucasian origin from Corielle cell repositories from the CEPH/UTAH library; and “SC_12_CA”=Caucasians—12 DNAs from Corielle cell repositories that are from the CEPH/UTAH library, six male and six female.
• Note that for SNPs of “Applera” SNP source, genes/regulatory regions of 39 individuals (20 Caucasians and 19 African Americans) were re-sequenced and, since each SNP position is represented by two chromosomes in each individual (with the exception of SNPs on X and Y chromosomes in males, for which each SNP position is represented by a single chromosome), up to 78 chromosomes were genotyped for each SNP position. Thus, the sum of the African-American (“afr”) allele counts is up to 38, the sum of the Caucasian allele counts (“cau”) is up to 40, and the total sum of all allele counts is up to 78.
• Note that semicolons separate population/allele/count information corresponding to each indicated SNP source; i.e., if four SNP sources are indicated, such as “Celera,” “dbSNP,” “HGBASE,” and “HGMD,” then population/allele/count information is provided in four groups which are separated by semicolons and listed in the same order as the listing of SNP sources, with each population/allele/count information group corresponding to the respective SNP source based on order; thus, in this example, the first population/allele/count information group would correspond to the first listed SNP source (Celera) and the third population/allele/count information group separated by semicolons would correspond to the third listed SNP source (HGBASE); if population/allele/count information is not available for any particular SNP source, then a pair of semicolons is still inserted as a place-holder in order to maintain correspondence between the list of SNP sources and the corresponding listing of population/allele/count information.
• • SNP type (e.g., location within gene/transcript and/or predicted functional effect) [“MISSENSE MUTATION”=SNP causes a change in the encoded amino acid (i.e., a non-synonymous coding SNP); “SILENT MUTATION”=SNP does not cause a change in the encoded amino acid (i.e., a synonymous coding SNP); “STOP CODON MUTATION”=SNP is located in a stop codon; “NONSENSE MUTATION”=SNP creates or destroys a stop codon; “UTR 5”=SNP is located in a 5′ UTR of a transcript; “UTR 3”=SNP is located in a 3′ UTR of a transcript; “PUTATIVE UTR 5”=SNP is located in a putative 5′ UTR; “PUTATIVE UTR 3”=SNP is located in a putative 3′ UTR; “DONOR SPLICE SITE”=SNP is located in a donor splice site (5′ intron boundary); “ACCEPTOR SPLICE SITE”=SNP is located in an acceptor splice site (3′ intron boundary); “CODING REGION”=SNP is located in a protein-coding region of the transcript; “EXON”=SNP is located in an exon; “INTRON”=SNP is located in an intron; “hmCS”=SNP is located in a human-mouse conserved segment; “TFBS”=SNP is located in a transcription factor binding site; “UNKNOWN”=SNP type is not defined; “INTERGENIC”=SNP is intergenic, i.e., outside of any gene boundary].
  • Protein coding information (Table 1 only), where relevant, in the format of [protein SEQ ID NO, amino acid position, (amino acid-1, codon1) (amino acid-2, codon2)]. The information in this field includes SEQ ID NO of the encoded protein sequence, position of the amino acid residue within the protein identified by the SEQ ID NO that is encoded by the codon containing the SNP, amino acids (represented by one-letter amino acid codes) that are encoded by the alternative SNP alleles (in the case of stop codons, “X” is used for the one-letter amino acid code), and alternative codons containing the alternative SNP nucleotides which encode the amino acid residues (thus, for example, for missense mutation-type SNPs, at least two different amino acids and at least two different codons are generally indicated; for silent mutation-type SNPs, one amino acid and at least two different codons are generally indicated, etc.). In instances where the SNP is located outside of a protein-coding region (e.g., in a UTR region), “None” is indicated following the protein SEQ ID NO.
• Description of Table 3
• Table 3 provides a list of linkage disequilibrium (LD) SNPs that are related to and derived from certain interrogated SNPs. The interrogated SNPs, which are those SNPs provided in Tables 4-22, are statistically significantly associated with, for example, response to statin treatment for reducing CVD/CHD risk, as described and shown herein. The LD SNPs provided in Table 3 all have an r² value at or above 0.9 (which was set as the Threshold r² value), and are provided as examples of SNPs which can also be used as markers for, for example, response to statin treatment for reducing risk of CVD (especially CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke) based on their being in high LD with an interrogated statin response-associated SNP.
• In Table 3, the columns labeled “Interrogated SNP” presents each interrogated SNP as identified by its unique hCV and rs identification number. The columns labeled “LD SNP” presents the hCV and rs numbers of the LD SNPs that are derived from their corresponding interrogated SNPs. The column labeled “Threshold r²” presents the minimum value of r² that an LD SNP must meet in reference to an interrogated SNP in order to be included in Table 3 (the Threshold r² value is set at 0.9 for all SNPs in Table 3). The column labeled “r²” presents the actual r² value of the LD SNP in reference to the interrogated SNP to which it is related (since the Threshold r² value is set at 0.9, all SNPs in Table 3 will have an r² value at or above 0.9). The criteria for selecting the LD SNPs provided in Table 3 are further described in Example 4 below.
• Sequences, SNP information, and associated gene/transcript/protein information for each of the LD SNPs listed in Table 3 is provided in Tables 1-2.
• Description of Tables 4-22
• Tables 4-22 provide the results of analyses for SNPs disclosed in Tables 1 and 2 (SNPs can be cross-referenced between all the tables herein based on their hCV and/or rs identification numbers). The results shown in Tables 4-22 provide support for the association of these SNPs with, for example, response to statin treatment for reducing the risk of CVD, particularly CHD (e.g., MI) and stroke.
• Tables 4-8
• The analyses in Tables 4-8 are further described in Example 1 below.
• Cohort and case-only study designs were used to identify SNPs associated with response to statin treatment in sample sets from the CARE, WOSCOPS, and PROVE-IT trials (these sample sets, with corresponding references, are described in Example 1 below). Specifically, analyses were carried out using the entire cohorts (individuals with and without incident CHD or CVD events) or cases only (only individuals with an incident CHD or CVD event) from these three sample sets (individually, as well as in combined meta-analyses) to identify SNPs associated with a reduction in the risk of CHD or CVD (CVD includes CHD and stroke) in response to statin treatment, and the results of these analyses are provided in Table 4-7 (Table 8 provides the degree of LD (r²) between pairs of SNPs listed in Tables 5 and 7).
• Tables 4-7 provides SNPs that had a synergy index (odds ratio) with P value lower than 10⁻⁴ in a meta-analysis of CARE and WOSCOPS combined (Table 4-5) or in a meta-analysis of CARE, WOSCOPS, and PROVE-IT combined (Table 6-7), in any genetic model (dominant, recessive, or additive) in either the CHD or CVD endpoint (the CHD or CVD endpoint is indicated in the last column, labeled “Endpoint”, of Tables 4-7, and the genetic model is indicated in the next to last column, labeled “Model”, of Tables 4-7). For each analysis, Tables 4-7 indicate whether the data comes from case-only analysis (“CaseOnly” in the “Source” column) or from analysis of the entire cohort (“cohort” in the “Source” column). Whenever cohort data was available, it was used in the meta-analysis.
• Tables 4-5 provide meta-analyses of CARE and WOSCOPS combined (2^nd section of each table) for two endpoints (CHD and CVD) and three genetic models (dominant, recessive, and additive), as well as logistic regression analyses of CARE (3^rd section of each table) and WOSCOPS (4^th section of each table) individually.
• Tables 6-7 provide meta-analyses of CARE, WOSCOPS, and PROVE-IT combined (2^nd section of each table) for two endpoints (CHD and CVD) and three genetic models (dominant, recessive, and additive), as well as logistic regression analyses of CARE (3^rd section of each table), WOSCOPS (4^th section of each table), and PROVE-IT (5^th section of each table) individually. For PROVE-IT, there was only one endpoint (the composite primary endpoint of the original PROVE-IT study, which includes some stroke cases), and this endpoint was used in meta-analysis of both CHD and CVD.
• Tables 5 and 7 provide analyses of certain LD SNPs in CARE and WOSCOPS (Table 5) and in CARE, WOSCOPS, and PROVE-IT (Table 7). For some SNPs, case-only data was available for a first SNP while cohort data was available for a SNP in LD with the first SNP (LD SNP), which occurred when a working kPCR assay could not be made for the first SNP. For these SNPs, the data for case-only analysis and the available data for the cohort is reported. The meta-analysis was performed using the cohort data when available. These SNPs are listed in Tables 5 and 7, with the two SNPs in LD listed one below the other, and the degree of LD between each of these pairs of SNPs is provided in Table 8.
• Notations in Tables 4-7 are as follows:
• In Tables 4-7, “allele A1” may be interchangeably referred to as the “non-reference allele” (“non-ref”), and “allele A2” may be interchangeably referred to as the “reference allele” (“ref”). The OR's that are indicated in Tables 4-7 correspond to the indicated “non-reference allele” (“allele A1”). Thus, if OR<1, the “non-reference allele” (“allele A1”) is associated with reduction of CVD/CHD risk by statin treatment, whereas if OR>1, the other alternative allele at the SNP (the “reference allele” or “allele A2”) is associated with reduction of CVD/CHD risk by statin treatment.
• The counts are indicated in the following format: allele A1 homozygotes/heterozygotes/allele A2 homozygotes. These counts indicate the number of individuals in the pravastatin (“Prava”), placebo, or atorvastatin (“Atorva”) arms of the CARE, WOSCOPS, or PROVE-IT trials (as indicated) who have the corresponding genotypes.
• In Tables 4-7, “P value” indicates the p-value, “OR” indicates the odds ratio (synergy index), “OR L95” and “OR U95” indicates the lower and upper (respectively) 95% confidence interval for the odds ratio, and “Source” indicates whether the data comes from case-only analysis (“CaseOnly”) or from analysis of the entire cohort (“cohort”).
• Tables 9-18
• Tables 9-18 provide additional SNPs associated with response to statin treatment for reducing CVD/CHD risk. Tables 9-18 differ from Tables 4-8 in that Tables 9-18 include SNPs analyzed by imputation as well as by genotyping, whereas all of the SNPs in Tables 4-8 were analyzed by genotyping. Imputation involves imputing the allele/genotype present at a SNP for each individual in the sample set (CARE, WOSCOPS, and PROVE-IT) rather than directly genotyping the SNP in a sample from the individual. The column labeled “Source” in each of Tables 9-18 indicates whether the data presented for each SNP was derived from imputation or from genotyping.
• Specifically, analyses were carried out using the same three sample sets as in Tables 4-8 (CARE, WOSCOPS, and PROVE-IT) to identify (by both genotyping and imputation) additional SNPs beyond those provided in Tables 4-8 that are also associated with a reduction in the risk of CHD or CVD. Tables 9-18 provide results of analyses of statin response for the same two endpoints as in Tables 4-8 (CHD in Tables 9-13, and CVD in Tables 14-18) and four genetic models (dominant, recessive, additive, and genotypic 2df).
• Tables 9-18 provide genotyped and imputed SNPs for which the p-value for a random effect was lower than 10⁻⁴ for either the meta-analysis of CARE and WOSCOPS combined or the meta-analysis of CARE, WOSCOPS, and PROVE-IT combined, for either the CHD or CVD endpoint, and for any genetic model (dominant, recessive, additive, or genotypic). Association interaction between statin response and either the CHD or CVD phenotype was performed.
• Tables 9-13 have CHD as an endpoint, whereas Tables 14-18 have CVD as an endpoint (CVD includes CHD and stroke).
• Tables 9 and 14 provide results of logistic regression analysis of the CARE sample set by direct genotyping and by imputing genotypes.
• Tables 10 and 15 provide results of logistic regression analysis of the WOSCOPS sample set by direct genotyping and by imputing genotypes.
• Tables 11 and 16 provide results of logistic regression analysis of the PROVE-IT sample set by direct genotyping and by imputing genotypes.
• Tables 12 and 17 provide results of meta-analysis of the CARE and WOSCOPS sample sets combined by direct genotyping and by imputing genotypes.
• Tables 13 and 18 provide results of meta-analysis of the CARE, WOSCOPS, and PROVE-IT sample sets combined by direct genotyping and by imputing genotypes.
• Notations in Tables 9-11 and 14-16 (for the analysis of CARE, WOSCOPS, and PROVE-IT sample sets individually) are as follows:
• “SOURCE” indicates whether each SNP was genotyped (“Genotyped”) or imputed (“Imputed”).
• “ALLELE” indicates the allele for which the given data (such as the OR) correspond to, which is also referred to herein as allele “A1” (and the other alternative allele at each SNP, which is not shown in Tables 9-11 and 14-16, but is shown in Tables 1-2 for each SNP, is referred to as allele “A2”).
• “MODEL” indicates whether the model was additive (“ADD”), recessive (“REC”), dominant (“DOM”), or genotypic 2df (“GEN”).
• “NMISS” indicates the number of genotypes present in the analysis (the number of non-missing genotypes).
• “OR” indicates the odds ratio (synergy index (SI)). If the odds ratio is less than one for the indicated allele (i.e., allele A1) then this indicates that this allele is associated with statin response (benefit from statin treatment), i.e., fewer CVD or CHD events (e.g., MI) were observed in individuals with this allele in the pravastatin arm of CARE or WOSCOPS or the atorvastatin arm of PROVE-IT, relative to individuals with this allele in the placebo arm of CARE or WOSCOPS or the pravastatin arm of PROVE-IT. If the odds ratio is greater than one for the indicated allele, then this indicates that the other alternative allele at the SNP (the allele which is not shown in Tables 9-11 and 14-16, but is indicated in Tables 1-2, i.e., allele A2), is associated with statin response (benefit from statin treatment).
• “SE” indicates standard error of the natural log of the synergy index (the synergy index is the odds ratio, labeled “OR”).
• “L95” and “U95” indicates the lower and upper (respectively) 95% confidence interval for the odds ratio.
• “STAT” is the test statistic used in evaluating the significance of an association in logistic regression analysis. The statistic is equal to the natural log of the synergy index divided by its standard error and follows a Gaussian distribution under the null hypothesis that the synergy index is equal to one.
• “P” indicates the p-value (corresponding to a statistical test of whether the synergy index is equal to one), and “HW_PVALUE” indicates the p-value corresponding to a statistical test of whether the distribution of genotypes among subjects in the study agrees with the distribution expected according to Hardy-Weinberg equilibrium.
• “ALLELE_FREQ” indicates the allele frequency of the given allele in the analyzed sample set (CARE in Tables 9 and 14; WOSCOPS in Tables 10 and 15; or PROVE-IT in Tables 11 and 16).
• “PRAVA_ALLELE_FREQ” or “ATORVA_ALLELE_FREQ” indicates the allele frequency of the given allele in the pravastatin or atorvastatin-treated arms (respectively) of the CARE, WOSCOPS, or PROVE-IT trials.
• “PRAVA_A1_HZ_COUNT”, “PRAVA_HET_COUNT”, and “PRAVA_A2_HZ_COUNT” (or, in Tables 11 and 16, “ATORVA_A1_HZ_COUNT”, “ATORVA_HET_COUNT”, and “ATORVA_A2_HZ_COUNT”) indicate the number of homozygotes of the allele that is indicated in the table (allele A1), the number of heterozygotes, and the number of homozygotes of the other alternative allele (allele A2) at the SNP, respectively, in the pravastatin arm of the CARE trial (in Tables 9 and 14) or the WOSCOPS trial (in Tables 10 and 15), or in the atorvastatin arm of the PROVE-IT trial (in Tables 11 and 16, in which the column headings labeled “atorvastatin” (“atorva”) are analogous to the column headings labeled “pravastatin” (“prava”) in Tables 9-10 and 14-15).
• “PLACEBO_A1_HZ_COUNT”, “PLACEBO_HET_COUNT”, and “PLACEBO_A2_HZ_COUNT” (or, in Tables 11 and 16, “PRAVA_A1_HZ_COUNT”, “PRAVA_HET_COUNT”, and “PRAVA_A2_HZ_COUNT”) indicate the number of homozygotes of the allele that is indicated in the table (allele A1), the number of heterozygotes, and the number of homozygotes of the other alternative allele (allele A2) at the SNP, respectively, in the placebo arm of the CARE trial (in Tables 9 and 14) or the WOSCOPS trial (in Tables 10 and 15), or in the pravastatin arm of the PROVE-IT trial (in Tables 11 and 16, in which the column headings labeled “pravastatin” (“prava”) are analogous to the column headings labeled “placebo” in Tables 9-10 and 14-15).
• Notations in Tables 12-13 and 17-18 (for the meta-analysis of CARE and WOSCOPS combined, and CARE, WOSCOPS, and PROVE-IT combined) are as follows:
• “SOURCE” indicates whether each SNP was genotyped or imputed.
• “ALLELE” indicates the allele for which the given data (such as the OR) correspond to, which is also referred to herein as allele “A1” (and the other alternative allele at each SNP, which is not shown in Tables 12-13 and 17-18, but is shown in Tables 1-2 for each SNP, is referred to as allele “A2”).
• “MODEL” indicates whether the model was additive, recessive, dominant, or genotypic.
• “P” indicates the p-value, and “P(R)” (or “P.R.”) indicates the p-value random effect. Both of these are p-values corresponding to a statistical test of whether the combined synergy index is equal to one but use different assumptions to derive the p-value. “P” is calculated using a fixed effects model, and “P(R)” is calculated using a random effects model.
• “OR” indicates the odds ratio (synergy index) calculated from a fixed effects model, and “OR(R)” (or “OR.R.”) indicates the odds ratio (synergy index) calculated from a random effects model. If the odds ratio is less than one for the indicated allele (i.e., allele A1) then this indicates that this allele is associated with statin response (benefit from statin treatment), i.e., fewer CVD or CHD events (e.g., MI) were observed in individuals with this allele in a combined meta-analysis of the pravastatin arms of CARE and WOSCOPS (Tables 12 and 17) and the atorvastatin arm of PROVE-IT (Tables 13 and 18), relative to individuals with this allele in the placebo arms of CARE and WOSCOPS (Tables 12 and 17) and the pravastatin arm of PROVE-IT (Tables 13 and 18). If the odds ratio is greater than one for the indicated allele, then this indicates that the other alternative allele at the SNP (the allele which is not shown in Tables 12-13 and 17-18, but is indicated in Tables 1-2, i.e., allele A2), is associated with statin response (benefit from statin treatment).
• “Q” indicates the Cochran Q test p-value, which is a p-value corresponding to the statistical test of the homogeneity of the synergy index across studies (small p-values indicate a greater degree of heterogeneity between studies).
• “I” indicates the I² heterogeneity index, which can be interpreted as the proportion of total variation in the estimates of effect that is due to heterogeneity between studies.
• Table 19
• The analysis in Table 19 is further described in Example 2 below.
• Notations in Table 19 are similar to Tables 4-7. “P.R.” and “OR.R.” indicate the p-value and odds ratio (synergy index), respectively, calculated from a random effects model (rather than a fixed effects model).
• Table 19 shows that SNP rs11556924 (hCV31283062) in the ZC3HC1 gene is associated with differential reduction of CHD risk by pravastatin therapy in both the CARE and WOSCOPS sample sets.
• Tables 20-22
• The analyses in Tables 20-22 are further described in Example 3 below.
• The results shown in Tables 20-22 provide support for the association of these SNPs with CVD risk and/or statin response, particularly risk for stroke and/or response to statin treatment for reducing the risk of stroke (Tables 20-21) and CHD (Table 22).
• Tables 20-21 provides SNPs associated with stroke risk and/or stroke statin response (reduction in stroke risk by statin treatment) in the CARE sample set. Consistent with the CARE trial, the stroke endpoint in the analysis for which the results are provided in Tables 20-21 included stroke as well as transient ischemic attack (TIA).
• Table 22 provides a SNP associated with CHD statin response in the CARE sample set. Table 22 shows that SNP rs873134 in the B4GALNT3 gene is associated with response to statin treatment for reducing the risk of CHD, particularly recurrent MI. In the analysis for which the results are provided in Table 22, the endpoint was recurrent MI, and the analysis was adjusted for age, gender, hypertension, diabetes, base LDL and HDL, and whether an individual was a current smoker.
• Notations in Tables 20-22 are as follows:
• In Tables 20-22, certain columns are labeled “RESP”, “PLACEBO, OR “ALL”. “RESP” is for statin response as measured by comparing risk (risk for stroke, including TIA, in Tables 20-21, and risk for CHD, specifically recurrent MI, in Table 22) in the pravastatin-treated group with risk in the placebo-treated group, “PLACEBO” is the placebo-treated group, and “ALL” is the combination of the placebo-treated group and the pravastatin-treated group. “RESP” is the analysis to assess statin response in the indicated genotype group.
• “MODE” indicates whether the model was additive (“ADD”), recessive (“REC”), dominant (“DOM”), or genotypic (“GEN”).
• “mAF CEU” (Table 20 only) indicates the frequency of the minor allele in HapMap for Europeans.
• “GENO” indicates the genotype.
• “STATIN” indicates either the pravastatin-treated (“Pravastatin”) or placebo-treated (“Placebo”) groups (i.e., arms of the CARE trial).
• “EVENTS” indicates the total number of events (stroke or TIA for Tables 20-21, and recurrent MI for Table 22) in individuals with the indicated genotype.
• “TOTAL” indicates the total number of individuals with the indicated genotype.
• “HR” indicates the hazard ratio.
• “L95” and “U95” indicates the lower and upper (respectively) 95% confidence interval for the hazard ratio.
• “P” indicates the p-value, “P_INT” indicates p-interaction, “P_DF2” indicates two degrees of freedom p-value, and “HW(ALL)pExact” (Table 21 only) indicates p exact for Hardy Weinberg Equilibrium for the ALL group.
• Throughout Tables 4-22, “OR” refers to the odds ratio, “HR” refers to the hazard ratio, and “OR L95” or “OR U95” refers to the lower and upper (respectively) 95% confidence interval for the odds ratio or hazard ratio. With respect to drug response (e.g., response to a statin), if the OR or HR of those treated with the drug (e.g., a statin) compared with those treated with a placebo within a particular genotype (or with a particular allele) is less than one, this indicates that an individual with this particular genotype or allele would benefit from the drug (an OR or HR equal to one would indicate that the drug has no effect). In contrast, with respect to drug response, if the OR or HR is greater than one for a particular allele, then this indicates that an individual with the other alternative allele would benefit from the drug. As used herein, the term “benefit” (with respect to a preventive or therapeutic drug treatment) is defined as achieving a reduced risk for a disease that the drug is intended to treat or prevent (e.g., CVD such as CHD, particularly MI) by administering the drug treatment, compared with the risk for the disease in the absence of receiving the drug treatment (or receiving a placebo in lieu of the drug treatment) for the same genotype.
• With respect to disease risk, an OR or HR that is greater than one indicates that a given allele is a risk allele (which may also be referred to as a susceptibility allele), whereas an OR or HR that is less than one indicates that a given allele is a non-risk allele (which may also be referred to as a protective allele). For a given risk allele, the other alternative allele at the SNP position (which can be derived from the information provided in Tables 1-2, for example) may be considered a non-risk allele. For a given non-risk allele, the other alternative allele at the SNP position may be considered a risk allele. Thus, with respect to disease risk, if the OR or HR for a particular allele at a SNP position is greater than one, this indicates that an individual with this particular allele has a higher risk for the disease than an individual who has the other allele at the SNP position. In contrast, if the OR or HR for a particular allele is less than one, this indicates that an individual with this particular allele has a reduced risk for the disease compared with an individual who has the other allele at the SNP position.
DETAILED DESCRIPTION OF THE INVENTION
• Exemplary embodiments of the present invention provide SNPs associated with response to statin treatment, particularly for reducing the risk of CVD (especially CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke), and methods for their use. The present invention further provides nucleic acid molecules containing these SNPs, methods and reagents for the detection of the SNPs disclosed herein, uses of these SNPs for the development of detection reagents, and assays or kits that utilize such reagents. The statin response-associated SNPs disclosed herein are particularly useful for predicting, screening for, and evaluating response to statin treatment, particularly for prevention or treatment of CVD (particularly CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke) using statins, in humans. The SNPs disclosed herein are also useful for diagnosing, prognosing, screening for, and evaluating predisposition to CVD, particularly CHD (such as MI) as well as cerebrovascular events such as stroke, in humans. Furthermore, such SNPs and their encoded products are useful targets for the development of therapeutic and preventive agents.
• Thus, exemplary embodiments of the present invention provide individual SNPs associated with response to statin treatments, particularly for reducing the risk of CVD (especially CHD, such as MI and other coronary events, as well as cerebrovascular events such as stroke), as well as combinations of SNPs and haplotypes, polymorphic/variant transcript sequences (SEQ ID NOS:1-51) and genomic sequences (SEQ ID NOS:177-622) containing SNPs, encoded amino acid sequences (SEQ ID NOS:52-102), and both transcript-based SNP context sequences (SEQ ID NOS:103-176) and genomic-based SNP context sequences (SEQ ID NOS:623-3661) (transcript sequences, protein sequences, and transcript-based SNP context sequences are provided in Table 1 and the Sequence Listing; genomic sequences and genomic-based SNP context sequences are provided in Table 2 and the Sequence Listing), methods of detecting these polymorphisms in a test sample, methods of determining if an individual is likely to respond to a particular treatment such as statins (particularly for treating or preventing CVD, such as CHD or stroke), methods of determining an individual's risk for developing CVD, methods of screening for compounds useful for treating CVD, compounds identified by these screening methods, methods of using the disclosed SNPs to select a treatment/preventive strategy or therapeutic agent, and methods of treating or preventing CVD.
• Exemplary embodiments of the present invention further provide methods for selecting or formulating a treatment regimen (e.g., methods for determining whether or not to administer statin treatment to an individual having CVD, or who is at risk for developing CVD in the future, or who has previously had CVD, methods for selecting a particular statin-based treatment regimen such as dosage and frequency of administration of statin, or a particular form/type of statin such as a particular pharmaceutical formulation or statin compound, methods for administering (either in addition to or instead of a statin) an alternative, non-statin-based treatment, such as niacin, fibrates, or ezetimibe (e.g., Zetia® or Ezetrol®), to individuals who are predicted to be unlikely to respond positively to statin treatment, etc.), and methods for determining the likelihood of experiencing toxicity or other undesirable side effects from statin treatment, etc. The present invention also provides methods for selecting individuals to whom a statin or other therapeutic will be administered based on the individual's genotype, and methods for selecting individuals for a clinical trial of a statin or other therapeutic agent based on the genotypes of the individuals (e.g., selecting individuals to participate in the trial who are most likely to respond positively from the statin treatment and/or excluding individuals from the trial who are unlikely to respond positively from the statin treatment based on their SNP genotype(s), or selecting individuals who are unlikely to respond positively to statins based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them).
• Exemplary embodiments of the present invention may include novel SNPs associated with response to statin treatment, as well as SNPs that were previously known in the art, but were not previously known to be associated with response to statin treatment. Accordingly, the present invention may provide novel compositions and methods based on novel SNPs disclosed herein, and may also provide novel methods of using known, but previously unassociated, SNPs in methods relating to, for example, methods relating to evaluating an individual's likelihood of responding to statin treatment (particularly statin treatment, including preventive treatment, of CVD, such as CHD or stroke), evaluating an individual's likelihood of having or developing CVD (particularly CHD or stroke), and predicting the likelihood of an individual experiencing a reccurrence of CVD (e.g., experiencing recurrent MI). In Tables 1 and 2, known SNPs are identified based on the public database in which they have been observed, which is indicated as one or more of the following SNP types: “dbSNP”=SNP observed in dbSNP, “HGBASE”=SNP observed in HGBASE, and “HGMD”=SNP observed in the Human Gene Mutation Database (HGMD).
• Particular alleles of the SNPs disclosed herein can be associated with either an increased likelihood of responding to statin treatment (particularly for reducing the risk of CVD, such as CHD (e.g., MI) or stroke) or increased risk of developing CVD (e.g., CHD or stroke), or a decreased likelihood of responding to statin treatment or a decreased risk of developing CVD. Thus, whereas certain SNPs (or their encoded products) can be assayed to determine whether an individual possesses a SNP allele that is indicative of an increased likelihood of responding to statin treatment or an increased risk of developing CVD, other SNPs (or their encoded products) can be assayed to determine whether an individual possesses a SNP allele that is indicative of a decreased likelihood of responding to statin treatment or a decreased risk of developing CVD. Similarly, particular alleles of the SNPs disclosed herein can be associated with either an increased or decreased likelihood of having a reccurrence of CVD (e.g., recurrent MI), etc. The term “altered” may be used herein to encompass either of these two possibilities (e.g., either an increased or a decreased likelihood/risk).
• SNP alleles that are associated with increased response to statin treatment for reducing CVD risk (benefit from statin treatment) may be referred to as “response” alleles, and SNP alleles that are associated with a lack of response to statin treatment may be referred to as “non-response” alleles. SNP alleles that are associated with an increased risk of having or developing CVD may be referred to as “risk” or “susceptibility” alleles, and SNP alleles that are associated with a decreased risk of having or developing CVD may be referred to as “non-risk” or “protective” alleles.
• In certain embodiments, the presence of a statin response allele disclosed herein in Tables 4-22 (an allele associated with increased response to statin treatment for reducing CVD or CHD risk) is detected and indicates that an individual has an increased risk for developing CVD, such as CHD (e.g., MI) or stroke. In these embodiments, in which the same allele is associated with both increased risk for developing CVD and increased response to statin treatment (i.e., the same allele is both a risk and a response allele), this increased risk for developing CVD can be reduced by administering statin treatment to an individual having the allele.
• Those skilled in the art will readily recognize that nucleic acid molecules may be double-stranded molecules and that reference to a particular site on one strand refers, as well, to the corresponding site on a complementary strand. In defining a SNP position, SNP allele, or nucleotide sequence, reference to an adenine, a thymine (uridine), a cytosine, or a guanine at a particular site on one strand of a nucleic acid molecule also defines the thymine (uridine), adenine, guanine, or cytosine (respectively) at the corresponding site on a complementary strand of the nucleic acid molecule. Thus, reference may be made to either strand in order to refer to a particular SNP position, SNP allele, or nucleotide sequence. Probes and primers, may be designed to hybridize to either strand and SNP genotyping methods disclosed herein may generally target either strand. Throughout the specification, in identifying a SNP position, reference is generally made to the protein-encoding strand, only for the purpose of convenience.
• References to variant peptides, polypeptides, or proteins of the present invention include peptides, polypeptides, proteins, or fragments thereof, that contain at least one amino acid residue that differs from the corresponding amino acid sequence of the art-known peptide/polypeptide/protein (the art-known protein may be interchangeably referred to as the “wild-type,” “reference,” or “normal” protein). Such variant peptides/polypeptides/proteins can result from a codon change caused by a nonsynonymous nucleotide substitution at a protein-coding SNP position (i.e., a missense mutation) disclosed by the present invention. Variant peptides/polypeptides/proteins of the present invention can also result from a nonsense mutation (i.e., a SNP that creates a premature stop codon, a SNP that generates a read-through mutation by abolishing a stop codon), or due to any SNP disclosed by the present invention that otherwise alters the structure, function, activity, or expression of a protein, such as a SNP in a regulatory region (e.g. a promoter or enhancer) or a SNP that leads to alternative or defective splicing, such as a SNP in an intron or a SNP at an exon/intron boundary. As used herein, the terms “polypeptide,” “peptide,” and “protein” are used interchangeably.
• As used herein, an “allele” may refer to a nucleotide at a SNP position (wherein at least two alternative nucleotides exist in the population at the SNP position, in accordance with the inherent definition of a SNP) or may refer to an amino acid residue that is encoded by the codon which contains the SNP position (where the alternative nucleotides that are present in the population at the SNP position form alternative codons that encode different amino acid residues). An “allele” may also be referred to herein as a “variant”. Also, an amino acid residue that is encoded by a codon containing a particular SNP may simply be referred to as being encoded by the SNP.
• A phrase such as “as represented by”, “as shown by”, “as symbolized by”, or “as designated by” may be used herein to refer to a SNP within a sequence (e.g., a polynucleotide context sequence surrounding a SNP), such as in the context of “a polymorphism as represented by position 101 of SEQ ID NO:X or its complement”. Typically, the sequence surrounding a SNP may be recited when referring to a SNP, however the sequence is not intended as a structural limitation beyond the specific SNP position itself. Rather, the sequence is recited merely as a way of referring to the SNP (in this example, “SEQ ID NO:X or its complement” is recited in order to refer to the SNP located at position 101 of SEQ ID NO:X, but SEQ ID NO:X or its complement is not intended as a structural limitation beyond the specific SNP position itself). In other words, it is recognized that the context sequence of SEQ ID NO:X in this example may contain one or more polymorphic nucleotide positions outside of position 101 and therefore an exact match over the full-length of SEQ ID NO:X is irrelevant since SEQ ID NO:X is only meant to provide context for referring to the SNP at position 101 of SEQ ID NO:X. Likewise, the length of the context sequence is also irrelevant (100 nucleotides on each side of a SNP position has been arbitrarily used in the present application as the length for context sequences merely for convenience and because 201 nucleotides of total length is expected to provide sufficient uniqueness to unambiguously identify a given nucleotide sequence). Thus, since a SNP is a variation at a single nucleotide position, it is customary to refer to context sequence (e.g., SEQ ID NO:X in this example) surrounding a particular SNP position in order to uniquely identify and refer to the SNP. Alternatively, a SNP can be referred to by a unique identification number such as a public “rs” identification number or an internal “hCV” identification number, such as provided herein for each SNP (e.g., in Tables 1-2). For example, in the instant application, “rs11556924”, “hCV31283062”, and “position 101 of SEQ ID NO:1074” all refer to the same SNP.
• As used herein, the term “benefit” (with respect to a preventive or therapeutic drug treatment, such as statin treatment) is defined as achieving a reduced risk for a disease that the drug is intended to treat or prevent (e.g., CVD such as CHD (particularly MI) or stroke) by administrating the drug treatment, compared with the risk for the disease in the absence of receiving the drug treatment (or receiving a placebo in lieu of the drug treatment) for the same genotype. The term “benefit” may be used herein interchangeably with terms such as “respond positively” or “positively respond”.
• As used herein, the terms “drug” and “therapeutic agent” are used interchangeably, and may include, but are not limited to, small molecule compounds, biologics (e.g., antibodies, proteins, protein fragments, fusion proteins, glycoproteins, etc.), nucleic acid agents (e.g., antisense, RNAi/siRNA, and microRNA molecules, etc.), vaccines, etc., which may be used for therapeutic and/or preventive treatment of a disease (e.g., CVD such as CHD or stroke).
• Examples of statins (also known as HMG-CoA reductase inhibitors) include, but are not limited to, atorvastatin (Lipitor®), rosuvastatin (Crestor®), pravastatin (Pravachol®), simvastatin (Zocor®), fluvastatin (Lescol®), and lovastatin (Mevacor®), as well as combination therapies that include a statin such as simvastatin+ezetimibe (Vytorin®), lovastatin+niacin (Advicor®), atorvastatin+amlodipine besylate (Caduet®), and simvastatin+niacin (Simcor®).
• Certain exemplary embodiments of the invention provide the following compositions and uses: (1) a reagent (such as an allele-specific probe or primer, or any other oligonucleotide or other reagent suitable for detecting a polymorphism disclosed herein, which can include detection of any allele of the polymorphism) for use as a diagnostic or predictive agent for determining statin response, particularly for reducing the risk of CVD such as CHD (e.g., MI) or stroke (and/or for determining risk for developing CVD); (2) a kit, device, array, or assay component that includes or is coupled with the reagent of (1) above for use in determining statin response, particularly for reducing the risk of CVD (and/or for determining risk for developing CVD); (3) the use of the reagent of (1) above for the manufacture of a kit, device, array, or assay component for determining statin response, particularly for reducing the risk of CVD (and/or for determining risk for CVD); and (4) the use of a polymorphism disclosed herein for the manufacture of a reagent for use as a diagnostic or predictive agent for determining statin response, particularly for reducing the risk of CVD (and/or for determining risk for developing CVD).
• The various methods described herein, such as correlating the presence or absence of a polymorphism with the predicted response of an individual to a drug such as a statin, particularly for reducing the risk for CVD such as CHD (e.g., MI) or stroke (and/or correlating the presence or absence of a polymorphism with an altered (e.g., increased or decreased) risk (or no altered risk) for developing CVD), can be carried out by automated methods such as by using a computer (or other apparatus/devices such as biomedical devices, laboratory instrumentation, or other apparatus/devices having a computer processor) programmed to carry out any of the methods described herein. For example, computer software (which may be interchangeably referred to herein as a computer program) can perform the step of correlating the presence or absence of a polymorphism in an individual with an altered (e.g., increased or decreased) response (or no altered response) to statin treatment, particularly for reducing the risk for CVD such as CHD (e.g., MI) or stroke. Accordingly, certain embodiments of the invention provide a computer (or other apparatus/device) programmed to carry out any of the methods described herein.
• Reports, Programmed Computers, Business Methods, and Systems
• The results of a test (e.g., an individual's predicted responsiveness to statin treatment for reducing CVD risk, or an individual's risk for developing CVD, based on assaying one or more SNPs disclosed herein, and/or an individual's allele(s)/genotype at one or more SNPs disclosed herein, etc.), and/or any other information pertaining to a test, may be referred to herein as a “report”. A tangible report can optionally be generated as part of a testing process (which may be interchangeably referred to herein as “reporting”, or as “providing” a report, “producing” a report, or “generating” a report).
• Examples of tangible reports may include, but are not limited to, reports in paper (such as computer-generated printouts of test results) or equivalent formats and reports stored on computer readable medium (such as a CD, USB flash drive or other removable storage device, computer hard drive, or computer network server, etc.). Reports, particularly those stored on computer readable medium, can be part of a database, which may optionally be accessible via the internet (such as a database of patient records or genetic information stored on a computer network server, which may be a “secure database” that has security features that limit access to the report, such as to allow only the patient and the patient's medical practioners to view the report while preventing other unauthorized individuals from viewing the report, for example). In addition to, or as an alternative to, generating a tangible report, reports can also be displayed on a computer screen (or the display of another electronic device or instrument).
• A report can include, for example, an individual's predicted responsiveness to statin treatment (e.g., whether the individual will benefit from statin treatment by having their risk for CVD, particularly CHD (e.g., MI) or stroke, reduced), or may just include the allele(s)/genotype that an individual carries at one or more SNPs disclosed herein, which may optionally be linked to information regarding the significance of having the allele(s)/genotype at the SNP (for example, a report on computer readable medium such as a network server may include hyperlink(s) to one or more journal publications or websites that describe the medical/biological implications, such as statin response and/or CVD risk, for individuals having a certain allele/genotype at the SNP). Thus, for example, the report can include drug responsiveness, disease risk, and/or other medical/biological significance, as well as optionally also including the allele/genotype information, or the report may just include allele/genotype information without including drug responsiveness, disease risk, or other medical/biological significance (such that an individual viewing the report can use the allele/genotype information to determine the associated drug response, disease risk, or other medical/biological significance from a source outside of the report itself, such as from a medical practioner, publication, website, etc., which may optionally be linked to the report such as by a hyperlink).
• A report can further be “transmitted” or “communicated” (these terms may be used herein interchangeably), such as to the individual who was tested, a medical practitioner (e.g., a doctor, nurse, clinical laboratory practitioner, genetic counselor, etc.), a healthcare organization, a clinical laboratory, and/or any other party or requester intended to view or possess the report. The act of “transmitting” or “communicating” a report can be by any means known in the art, based on the format of the report. Furthermore, “transmitting” or “communicating” a report can include delivering/sending a report (“pushing”) and/or retrieving (“pulling”) a report. For example, reports can be transmitted/communicated by various means, including being physically transferred between parties (such as for reports in paper format) such as by being physically delivered from one party to another, or by being transmitted electronically or in signal form (e.g., via e-mail or over the internet, by facsimile, and/or by any wired or wireless communication methods known in the art) such as by being retrieved from a database stored on a computer network server, etc.
• In certain exemplary embodiments, the invention provides computers (or other apparatus/devices such as biomedical devices or laboratory instrumentation) programmed to carry out the methods described herein. For example, in certain embodiments, the invention provides a computer programmed to receive (i.e., as input) the identity (e.g., the allele(s) or genotype at a SNP) of one or more SNPs disclosed herein and provide (i.e., as output) the predicted drug responsiveness or disease risk (e.g., an individual's predicted statin responsiveness or risk for developing CVD) or other result based on the identity of the SNP(s). Such output (e.g., communication of disease risk, disease diagnosis or prognosis, drug responsiveness, etc.) may be, for example, in the form of a report on computer readable medium, printed in paper form, and/or displayed on a computer screen or other display.
• In various exemplary embodiments, the invention further provides methods of doing business (with respect to methods of doing business, the terms “individual” and “customer” are used herein interchangeably). For example, exemplary methods of doing business can comprise assaying one or more SNPs disclosed herein and providing a report that includes, for example, a customer's predicted response to statin treatment (e.g., for reducing their risk for CVD, particularly CHD (such as MI) or stroke) or their risk for developing CVD (based on which allele(s)/genotype is present at the assayed SNP(s)) and/or that includes the allele(s)/genotype at the assayed SNP(s) which may optionally be linked to information (e.g., journal publications, websites, etc.) pertaining to disease risk or other biological/medical significance such as by means of a hyperlink (the report may be provided, for example, on a computer network server or other computer readable medium that is internet-accessible, and the report may be included in a secure database that allows the customer to access their report while preventing other unauthorized individuals from viewing the report), and optionally transmitting the report. Customers (or another party who is associated with the customer, such as the customer's doctor, for example) can request/order (e.g., purchase) the test online via the internet (or by phone, mail order, at an outlet/store, etc.), for example, and a kit can be sent/delivered (or otherwise provided) to the customer (or another party on behalf of the customer, such as the customer's doctor, for example) for collection of a biological sample from the customer (e.g., a buccal swab for collecting buccal cells), and the customer (or a party who collects the customer's biological sample) can submit their biological samples for assaying (e.g., to a laboratory or party associated with the laboratory such as a party that accepts the customer samples on behalf of the laboratory, a party for whom the laboratory is under the control of (e.g., the laboratory carries out the assays by request of the party or under a contract with the party, for example), and/or a party that receives at least a portion of the customer's payment for the test). The report (e.g., results of the assay including, for example, the customer's disease risk and/or allele(s)/genotype at the assayed SNP(s)) may be provided to the customer by, for example, the laboratory that assays the SNP(s) or a party associated with the laboratory (e.g., a party that receives at least a portion of the customer's payment for the assay, or a party that requests the laboratory to carry out the assays or that contracts with the laboratory for the assays to be carried out) or a doctor or other medical practitioner who is associated with (e.g., employed by or having a consulting or contracting arrangement with) the laboratory or with a party associated with the laboratory, or the report may be provided to a third party (e.g., a doctor, genetic counselor, hospital, etc.) which optionally provides the report to the customer. In further embodiments, the customer may be a doctor or other medical practitioner, or a hospital, laboratory, medical insurance organization, or other medical organization that requests/orders (e.g., purchases) tests for the purposes of having other individuals (e.g., their patients or customers) assayed for one or more SNPs disclosed herein and optionally obtaining a report of the assay results.
• In certain exemplary methods of doing business, a kit for collecting a biological sample (e.g., a buccal swab for collecting buccal cells, or other sample collection device) is provided to a medical practitioner (e.g., a physician) which the medical practitioner uses to obtain a sample (e.g., buccal cells, saliva, blood, etc.) from a patient, the sample is then sent to a laboratory (e.g., a CLIA-certified laboratory) or other facility that tests the sample for one or more SNPs disclosed herein (e.g., to determine the genotype of one or more SNPs disclosed herein, such as to determine the patient's predicted response to statin treatment for reducing their risk for CVD, particularly CHD (such as MI) or stroke, and/or their risk for developing CVD), and the results of the test (e.g., the patient's genotype at one or more SNPs disclosed herein and/or the patient's predicted statin response or CVD risk based on their SNP genotype) are provided back to the medical practitioner (and/or directly to the patient and/or to another party such as a hospital, medical insurance company, genetic counselor, etc.) who may then provide or otherwise convey the results to the patient. The results are typically provided in the form of a report, such as described above.
• In certain further exemplary methods of doing business, kits for collecting a biological sample from a customer (e.g., a buccal swab for collecting buccal cells, or other sample collection device) are provided (e.g., for sale), such as at an outlet (e.g., a drug store, pharmacy, general merchandise store, or any other desirable outlet), online via the internet, by mail order, etc., whereby customers can obtain (e.g., purchase) the kits, collect their own biological samples, and submit (e.g., send/deliver via mail) their samples to a laboratory (e.g., a CLIA-certified laboratory) or other facility which tests the samples for one or more SNPs disclosed herein (e.g., to determine the genotype of one or more SNPs disclosed herein, such as to determine the customer's predicted response to statin treatment for reducing their risk for CVD, particularly CHD (e.g., MI) or stroke, and/or their risk for developing CVD) and provides the results of the test (e.g., of the customer's genotype at one or more SNPs disclosed herein and/or the customer's statin response or CVD risk based on their SNP genotype) back to the customer and/or to a third party (e.g., a physician or other medical practitioner, hospital, medical insurance company, genetic counselor, etc.). The results are typically provided in the form of a report, such as described above. If the results of the test are provided to a third party, then this third party may optionally provide another report to the customer based on the results of the test (e.g., the result of the test from the laboratory may provide the customer's genotype at one or more SNPs disclosed herein without statin response or CVD risk information, and the third party may provide a report of the customer's statin response or CVD risk based on this genotype result).
• Certain further embodiments of the invention provide a system for determining whether an individual will benefit from statin treatment (or other therapy) in reducing CVD risk (particularly risk for CHD (such as MI) or stroke), or for determining an individual's risk for developing CVD. Certain exemplary systems comprise an integrated “loop” in which an individual (or their medical practitioner) requests a determination of such individual's predicted statin response (or CVD risk, etc.), this determination is carried out by testing a sample from the individual, and then the results of this determination are provided back to the requestor. For example, in certain systems, a sample (e.g., buccal cells, saliva, blood, etc.) is obtained from an individual for testing (the sample may be obtained by the individual or, for example, by a medical practitioner), the sample is submitted to a laboratory (or other facility) for testing (e.g., determining the genotype of one or more SNPs disclosed herein), and then the results of the testing are sent to the patient (which optionally can be done by first sending the results to an intermediary, such as a medical practioner, who then provides or otherwise conveys the results to the individual and/or acts on the results), thereby forming an integrated loop system for determining an individual's predicted statin response (or CVD risk, etc.). The portions of the system in which the results are transmitted (e.g., between any of a testing facility, a medical practitioner, and/or the individual) can be carried out by way of electronic or signal transmission (e.g., by computer such as via e-mail or the internet, by providing the results on a website or computer network server which may optionally be a secure database, by phone or fax, or by any other wired or wireless transmission methods known in the art). Optionally, the system can further include a risk reduction component (i.e., a disease management system) as part of the integrated loop (for an example of a disease management system, see U.S. Pat. No. 6,770,029, “Disease management system and method including correlation assessment”). For example, the results of the test can be used to reduce the risk of the disease in the individual who was tested, such as by implementing a preventive therapy regimen (e.g., administration of a statin or other drug for reducing CVD risk), modifying the individual's diet, increasing exercise, reducing stress, and/or implementing any other physiological or behavioral modifications in the individual with the goal of reducing disease risk. For reducing CVD risk, this may include any means used in the art for improving aspects of an individual's health relevant to reducing CVD risk. Thus, in exemplary embodiments, the system is controlled by the individual and/or their medical practioner in that the individual and/or their medical practioner requests the test, receives the test results back, and (optionally) acts on the test results to reduce the individual's disease risk, such as by implementing a disease management system.
• Isolated Nucleic Acid Molecules and SNP Detection Reagents & Kits
• Tables 1 and 2 provide a variety of information about each SNP of the present invention that is associated with response to statin treatment, particularly for reducing an individual's risk for CVD such as CHD (e.g., MI) or stroke, including the transcript sequences (SEQ ID NOS:1-51), genomic sequences (SEQ ID NOS:177-622), and protein sequences (SEQ ID NOS:52-102) of the encoded gene products (with the SNPs indicated by IUB codes in the nucleic acid sequences). In addition, Tables 1 and 2 include SNP context sequences, which generally include 100 nucleotide upstream (5′) plus 100 nucleotides downstream (3′) of each SNP position (SEQ ID NOS:103-176 correspond to transcript-based SNP context sequences disclosed in Table 1, and SEQ ID NOS:623-3661 correspond to genomic-based context sequences disclosed in Table 2), the alternative nucleotides (alleles) at each SNP position, and additional information about the variant where relevant, such as SNP type (coding, missense, splice site, UTR, etc.), human populations in which the SNP was observed, observed allele frequencies, information about the encoded protein, etc.
• Isolated Nucleic Acid Molecules
• Exemplary embodiments of the invention provide isolated nucleic acid molecules that contain one or more SNPs disclosed herein, particularly SNPs disclosed in Table 1 and/or Table 2. Isolated nucleic acid molecules containing one or more SNPs disclosed herein (such as in at least one of Tables 1 and 2) may be interchangeably referred to throughout the present text as “SNP-containing nucleic acid molecules.” Isolated nucleic acid molecules may optionally encode a full-length variant protein or fragment thereof. The isolated nucleic acid molecules of the present invention also include probes and primers (which are described in greater detail below in the section entitled “SNP Detection Reagents”), which may be used for assaying the disclosed SNPs, and isolated full-length genes, transcripts, cDNA molecules, and fragments thereof, which may be used for such purposes as expressing an encoded protein.
• As used herein, an “isolated nucleic acid molecule” generally is one that contains a SNP of the present invention or one that hybridizes to such molecule such as a nucleic acid with a complementary sequence, and is separated from most other nucleic acids present in the natural source of the nucleic acid molecule. Moreover, an “isolated” nucleic acid molecule, such as a cDNA molecule containing a SNP of the present invention, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. A nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered “isolated.” Nucleic acid molecules present in non-human transgenic animals, which do not naturally occur in the animal, are also considered “isolated.” For example, recombinant DNA molecules contained in a vector are considered “isolated.” Further examples of “isolated” DNA molecules include recombinant DNA molecules maintained in heterologous host cells, and purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the isolated SNP-containing DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically.
• Generally, an isolated SNP-containing nucleic acid molecule comprises one or more SNP positions disclosed by the present invention with flanking nucleotide sequences on either side of the SNP positions. A flanking sequence can include nucleotide residues that are naturally associated with the SNP site and/or heterologous nucleotide sequences. Preferably, the flanking sequence is up to about 500, 300, 100, 60, 50, 30, 25, 20, 15, 10, 8, or 4 nucleotides (or any other length in-between) on either side of a SNP position, or as long as the full-length gene or entire protein-coding sequence (or any portion thereof such as an exon), especially if the SNP-containing nucleic acid molecule is to be used to produce a protein or protein fragment.
• For full-length genes and entire protein-coding sequences, a SNP flanking sequence can be, for example, up to about 5 KB, 4 KB, 3 KB, 2 KB, 1 KB on either side of the SNP. Furthermore, in such instances the isolated nucleic acid molecule comprises exonic sequences (including protein-coding and/or non-coding exonic sequences), but may also include intronic sequences. Thus, any protein coding sequence may be either contiguous or separated by introns. The important point is that the nucleic acid is isolated from remote and unimportant flanking sequences and is of appropriate length such that it can be subjected to the specific manipulations or uses described herein such as recombinant protein expression, preparation of probes and primers for assaying the SNP position, and other uses specific to the SNP-containing nucleic acid sequences.
• An isolated SNP-containing nucleic acid molecule can comprise, for example, a full-length gene or transcript, such as a gene isolated from genomic DNA (e.g., by cloning or PCR amplification), a cDNA molecule, or an mRNA transcript molecule. Polymorphic transcript sequences are referred to in Table 1 and provided in the Sequence Listing (SEQ ID NOS:1-51), and polymorphic genomic sequences are referred to in Table 2 and provided in the Sequence Listing (SEQ ID NOS:177-622). Furthermore, fragments of such full-length genes and transcripts that contain one or more SNPs disclosed herein are also encompassed by the present invention, and such fragments may be used, for example, to express any part of a protein, such as a particular functional domain or an antigenic epitope.
• Thus, the present invention also encompasses fragments of the nucleic acid sequences as disclosed in Tables 1 and 2 (transcript sequences are referred to in Table 1 as SEQ ID NOS:1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS:177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS:103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS:623-3661) and their complements. The actual sequences referred to in the tables are provided in the Sequence Listing. A fragment typically comprises a contiguous nucleotide sequence at least about 8 or more nucleotides, more preferably at least about 12 or more nucleotides, and even more preferably at least about 16 or more nucleotides. Furthermore, a fragment could comprise at least about 18, 20, 22, 25, 30, 40, 50, 60, 80, 100, 150, 200, 250 or 500 nucleotides in length (or any other number in between). The length of the fragment will be based on its intended use. For example, the fragment can encode epitope-bearing regions of a variant peptide or regions of a variant peptide that differ from the normal/wild-type protein, or can be useful as a polynucleotide probe or primer. Such fragments can be isolated using the nucleotide sequences provided in Table 1 and/or Table 2 for the synthesis of a polynucleotide probe. A labeled probe can then be used, for example, to screen a cDNA library, genomic DNA library, or mRNA to isolate nucleic acid corresponding to the coding region. Further, primers can be used in amplification reactions, such as for purposes of assaying one or more SNPs sites or for cloning specific regions of a gene.
• An isolated nucleic acid molecule of the present invention further encompasses a SNP-containing polynucleotide that is the product of any one of a variety of nucleic acid amplification methods, which are used to increase the copy numbers of a polynucleotide of interest in a nucleic acid sample. Such amplification methods are well known in the art, and they include but are not limited to, polymerase chain reaction (PCR) (U.S. Pat. Nos. 4,683,195 and 4,683,202; PCR Technology: Principles and Applications for DNA Amplification, ed. H. A. Erlich, Freeman Press, NY, N.Y. (1992)), ligase chain reaction (LCR) (Wu and Wallace, Genomics 4:560 (1989); Landegren et al., Science 241:1077 (1988)), strand displacement amplification (SDA) (U.S. Pat. Nos. 5,270,184 and 5,422,252), transcription-mediated amplification (TMA) (U.S. Pat. No. 5,399,491), linked linear amplification (LLA) (U.S. Pat. No. 6,027,923) and the like, and isothermal amplification methods such as nucleic acid sequence based amplification (NASBA) and self-sustained sequence replication (Guatelli et al., Proc Natl Acad Sci USA 87:1874 (1990)). Based on such methodologies, a person skilled in the art can readily design primers in any suitable regions 5′ and 3′ to a SNP disclosed herein. Such primers may be used to amplify DNA of any length so long that it contains the SNP of interest in its sequence.
• As used herein, an “amplified polynucleotide” of the invention is a SNP-containing nucleic acid molecule whose amount has been increased at least two fold by any nucleic acid amplification method performed in vitro as compared to its starting amount in a test sample. In other preferred embodiments, an amplified polynucleotide is the result of at least ten fold, fifty fold, one hundred fold, one thousand fold, or even ten thousand fold increase as compared to its starting amount in a test sample. In a typical PCR amplification, a polynucleotide of interest is often amplified at least fifty thousand fold in amount over the unamplified genomic DNA, but the precise amount of amplification needed for an assay depends on the sensitivity of the subsequent detection method used.
• Generally, an amplified polynucleotide is at least about 16 nucleotides in length. More typically, an amplified polynucleotide is at least about 20 nucleotides in length. In a preferred embodiment of the invention, an amplified polynucleotide is at least about 30 nucleotides in length. In a more preferred embodiment of the invention, an amplified polynucleotide is at least about 32, 40, 45, 50, or 60 nucleotides in length. In yet another preferred embodiment of the invention, an amplified polynucleotide is at least about 100, 200, 300, 400, or 500 nucleotides in length. While the total length of an amplified polynucleotide of the invention can be as long as an exon, an intron or the entire gene where the SNP of interest resides, an amplified product is typically up to about 1,000 nucleotides in length (although certain amplification methods may generate amplified products greater than 1000 nucleotides in length). More preferably, an amplified polynucleotide is not greater than about 600-700 nucleotides in length. It is understood that irrespective of the length of an amplified polynucleotide, a SNP of interest may be located anywhere along its sequence.
• In a specific embodiment of the invention, the amplified product is at least about 201 nucleotides in length, comprises one of the transcript-based context sequences or the genomic-based context sequences shown in Tables 1 and 2. Such a product may have additional sequences on its 5′ end or 3′ end or both. In another embodiment, the amplified product is about 101 nucleotides in length, and it contains a SNP disclosed herein. Preferably, the SNP is located at the middle of the amplified product (e.g., at position 101 in an amplified product that is 201 nucleotides in length, or at position 51 in an amplified product that is 101 nucleotides in length), or within 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, or 20 nucleotides from the middle of the amplified product. However, as indicated above, the SNP of interest may be located anywhere along the length of the amplified product.
• The present invention provides isolated nucleic acid molecules that comprise, consist of, or consist essentially of one or more polynucleotide sequences that contain one or more SNPs disclosed herein, complements thereof, and SNP-containing fragments thereof.
• Accordingly, the present invention provides nucleic acid molecules that consist of any of the nucleotide sequences shown in Table 1 and/or Table 2 (transcript sequences are referred to in Table 1 as SEQ ID NOS:1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS:177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS:103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS:623-3661), or any nucleic acid molecule that encodes any of the variant proteins referred to in Table 1 (SEQ ID NOS:52-102). The actual sequences referred to in the tables are provided in the Sequence Listing. A nucleic acid molecule consists of a nucleotide sequence when the nucleotide sequence is the complete nucleotide sequence of the nucleic acid molecule.
• The present invention further provides nucleic acid molecules that consist essentially of any of the nucleotide sequences referred to in Table 1 and/or Table 2 (transcript sequences are referred to in Table 1 as SEQ ID NOS:1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS:177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS:103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS:623-3661), or any nucleic acid molecule that encodes any of the variant proteins referred to in Table 1 (SEQ ID NOS:52-102). The actual sequences referred to in the tables are provided in the Sequence Listing. A nucleic acid molecule consists essentially of a nucleotide sequence when such a nucleotide sequence is present with only a few additional nucleotide residues in the final nucleic acid molecule.
• The present invention further provides nucleic acid molecules that comprise any of the nucleotide sequences shown in Table 1 and/or Table 2 or a SNP-containing fragment thereof (transcript sequences are referred to in Table 1 as SEQ ID NOS:1-51, genomic sequences are referred to in Table 2 as SEQ ID NOS:177-622, transcript-based SNP context sequences are referred to in Table 1 as SEQ ID NOS:103-176, and genomic-based SNP context sequences are referred to in Table 2 as SEQ ID NOS:623-3661), or any nucleic acid molecule that encodes any of the variant proteins provided in Table 1 (SEQ ID NOS:52-102). The actual sequences referred to in the tables are provided in the Sequence Listing. A nucleic acid molecule comprises a nucleotide sequence when the nucleotide sequence is at least part of the final nucleotide sequence of the nucleic acid molecule. In such a fashion, the nucleic acid molecule can be only the nucleotide sequence or have additional nucleotide residues, such as residues that are naturally associated with it or heterologous nucleotide sequences. Such a nucleic acid molecule can have one to a few additional nucleotides or can comprise many more additional nucleotides. A brief description of how various types of these nucleic acid molecules can be readily made and isolated is provided below, and such techniques are well known to those of ordinary skill in the art. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, N.Y. (2000).
• The isolated nucleic acid molecules can encode mature proteins plus additional amino or carboxyl-terminal amino acids or both, or amino acids interior to the mature peptide (when the mature form has more than one peptide chain, for instance). Such sequences may play a role in processing of a protein from precursor to a mature form, facilitate protein trafficking, prolong or shorten protein half-life, or facilitate manipulation of a protein for assay or production. As generally is the case in situ, the additional amino acids may be processed away from the mature protein by cellular enzymes.
• Thus, the isolated nucleic acid molecules include, but are not limited to, nucleic acid molecules having a sequence encoding a peptide alone, a sequence encoding a mature peptide and additional coding sequences such as a leader or secretory sequence (e.g., a pre-pro or pro-protein sequence), a sequence encoding a mature peptide with or without additional coding sequences, plus additional non-coding sequences, for example introns and non-coding 5′ and 3′ sequences such as transcribed but untranslated sequences that play a role in, for example, transcription, mRNA processing (including splicing and polyadenylation signals), ribosome binding, and/or stability of mRNA. In addition, the nucleic acid molecules may be fused to heterologous marker sequences encoding, for example, a peptide that facilitates purification.
• Isolated nucleic acid molecules can be in the form of RNA, such as mRNA, or in the form DNA, including cDNA and genomic DNA, which may be obtained, for example, by molecular cloning or produced by chemical synthetic techniques or by a combination thereof. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, N.Y. (2000). Furthermore, isolated nucleic acid molecules, particularly SNP detection reagents such as probes and primers, can also be partially or completely in the form of one or more types of nucleic acid analogs, such as peptide nucleic acid (PNA). U.S. Pat. Nos. 5,539,082; 5,527,675; 5,623,049; and 5,714,331. The nucleic acid, especially DNA, can be double-stranded or single-stranded. Single-stranded nucleic acid can be the coding strand (sense strand) or the complementary non-coding strand (anti-sense strand). DNA, RNA, or PNA segments can be assembled, for example, from fragments of the human genome (in the case of DNA or RNA) or single nucleotides, short oligonucleotide linkers, or from a series of oligonucleotides, to provide a synthetic nucleic acid molecule. Nucleic acid molecules can be readily synthesized using the sequences provided herein as a reference; oligonucleotide and PNA oligomer synthesis techniques are well known in the art. See, e.g., Corey, “Peptide nucleic acids: expanding the scope of nucleic acid recognition,” Trends Biotechnol 15(6):224-9 (June 1997), and Hyrup et al., “Peptide nucleic acids (PNA): synthesis, properties and potential applications,” Bioorg Med Chem 4(1):5-23) (January 1996). Furthermore, large-scale automated oligonucleotide/PNA synthesis (including synthesis on an array or bead surface or other solid support) can readily be accomplished using commercially available nucleic acid synthesizers, such as the Applied Biosystems (Foster City, Calif.) 3900 High-Throughput DNA Synthesizer or Expedite 8909 Nucleic Acid Synthesis System, and the sequence information provided herein.
• The present invention encompasses nucleic acid analogs that contain modified, synthetic, or non-naturally occurring nucleotides or structural elements or other alternative/modified nucleic acid chemistries known in the art. Such nucleic acid analogs are useful, for example, as detection reagents (e.g., primers/probes) for detecting one or more SNPs identified in Table 1 and/or Table 2. Furthermore, kits/systems (such as beads, arrays, etc.) that include these analogs are also encompassed by the present invention. For example, PNA oligomers that are based on the polymorphic sequences of the present invention are specifically contemplated. PNA oligomers are analogs of DNA in which the phosphate backbone is replaced with a peptide-like backbone. Lagriffoul et al., Bioorganic & Medicinal Chemistry Letters 4:1081-1082 (1994); Petersen et al., Bioorganic & Medicinal Chemistry Letters 6:793-796 (1996); Kumar et al., Organic Letters 3(9):1269-1272 (2001); WO 96/04000. PNA hybridizes to complementary RNA or DNA with higher affinity and specificity than conventional oligonucleotides and oligonucleotide analogs. The properties of PNA enable novel molecular biology and biochemistry applications unachievable with traditional oligonucleotides and peptides.
• Additional examples of nucleic acid modifications that improve the binding properties and/or stability of a nucleic acid include the use of base analogs such as inosine, intercalators (U.S. Pat. No. 4,835,263) and the minor groove binders (U.S. Pat. No. 5,801,115). Thus, references herein to nucleic acid molecules, SNP-containing nucleic acid molecules, SNP detection reagents (e.g., probes and primers), oligonucleotides/polynucleotides include PNA oligomers and other nucleic acid analogs. Other examples of nucleic acid analogs and alternative/modified nucleic acid chemistries known in the art are described in Current Protocols in Nucleic Acid Chemistry, John Wiley & Sons, N.Y. (2002).
• The present invention further provides nucleic acid molecules that encode fragments of the variant polypeptides disclosed herein as well as nucleic acid molecules that encode obvious variants of such variant polypeptides. Such nucleic acid molecules may be naturally occurring, such as paralogs (different locus) and orthologs (different organism), or may be constructed by recombinant DNA methods or by chemical synthesis. Non-naturally occurring variants may be made by mutagenesis techniques, including those applied to nucleic acid molecules, cells, or organisms. Accordingly, the variants can contain nucleotide substitutions, deletions, inversions and insertions (in addition to the SNPs disclosed in Tables 1 and 2). Variation can occur in either or both the coding and non-coding regions. The variations can produce conservative and/or non-conservative amino acid substitutions.
• Further variants of the nucleic acid molecules disclosed in Tables 1 and 2, such as naturally occurring allelic variants (as well as orthologs and paralogs) and synthetic variants produced by mutagenesis techniques, can be identified and/or produced using methods well known in the art. Such further variants can comprise a nucleotide sequence that shares at least 70-80%, 80-85%, 85-90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with a nucleic acid sequence disclosed in Table 1 and/or Table 2 (or a fragment thereof) and that includes a novel SNP allele disclosed in Table 1 and/or Table 2. Further, variants can comprise a nucleotide sequence that encodes a polypeptide that shares at least 70-80%, 80-85%, 85-90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with a polypeptide sequence disclosed in Table 1 (or a fragment thereof) and that includes a novel SNP allele disclosed in Table 1 and/or Table 2. Thus, an aspect of the present invention that is specifically contemplated are isolated nucleic acid molecules that have a certain degree of sequence variation compared with the sequences shown in Tables 1-2, but that contain a novel SNP allele disclosed herein. In other words, as long as an isolated nucleic acid molecule contains a novel SNP allele disclosed herein, other portions of the nucleic acid molecule that flank the novel SNP allele can vary to some degree from the specific transcript, genomic, and context sequences referred to and shown in Tables 1 and 2, and can encode a polypeptide that varies to some degree from the specific polypeptide sequences referred to in Table 1.
• To determine the percent identity of two amino acid sequences or two nucleotide sequences of two molecules that share sequence homology, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in one or both of a first and a second amino acid or nucleic acid sequence for optimal alignment and non-homologous sequences can be disregarded for comparison purposes). In a preferred embodiment, at least 30%, 40%, 50%, 60%, 70%, 80%, or 90% or more of the length of a reference sequence is aligned for comparison purposes. The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in the first sequence is occupied by the same amino acid residue or nucleotide as the corresponding position in the second sequence, then the molecules are identical at that position (as used herein, amino acid or nucleic acid “identity” is equivalent to amino acid or nucleic acid “homology”). The percent identity between the two sequences is a function of the number of identical positions shared by the sequences, taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences.
• The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm. Computational Molecular Biology, A. M. Lesk, ed., Oxford University Press, N.Y (1988); Biocomputing: Informatics and Genome Projects, D. W. Smith, ed., Academic Press, N.Y. (1993); Computer Analysis of Sequence Data, Part 1, A. M. Griffin and H. G. Griffin, eds., Humana Press, N.J. (1994); Sequence Analysis in Molecular Biology, G. von Heinje, ed., Academic Press, N.Y. (1987); and Sequence Analysis Primer, M. Gribskov and J. Devereux, eds., M. Stockton Press, N.Y. (1991). In a preferred embodiment, the percent identity between two amino acid sequences is determined using the Needleman and Wunsch algorithm (J Mol Biol (48):444-453 (1970)) which has been incorporated into the GAP program in the GCG software package, using either a Blossom 62 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6.
• In yet another preferred embodiment, the percent identity between two nucleotide sequences is determined using the GAP program in the GCG software package using a NWSgapdna.CMP matrix and a gap weight of 40, 50, 60, 70, or 80 and a length weight of 1, 2, 3, 4, 5, or 6. J. Devereux et al., Nucleic Acids Res. 12(1):387 (1984). In another embodiment, the percent identity between two amino acid or nucleotide sequences is determined using the algorithm of E. Myers and W. Miller (CABIOS 4:11-17 (1989)) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12, and a gap penalty of 4.
• The nucleotide and amino acid sequences of the present invention can further be used as a “query sequence” to perform a search against sequence databases; for example, to identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0). Altschul et al., J Mol Biol 215:403-10 (1990). BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to the nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to the proteins of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized. Altschul et al., Nucleic Acids Res 25(17):3389-3402 (1997). When utilizing BLAST and gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used. In addition to BLAST, examples of other search and sequence comparison programs used in the art include, but are not limited to, FASTA (Pearson, Methods Mol Biol 25, 365-389 (1994)) and KERR (Dufresne et al., Nat Biotechnol 20(12):1269-71 (December 2002)). For further information regarding bioinformatics techniques, see Current Protocols in Bioinformatics, John Wiley & Sons, Inc., N.Y.
• The present invention further provides non-coding fragments of the nucleic acid molecules disclosed in Table 1 and/or Table 2. Preferred non-coding fragments include, but are not limited to, promoter sequences, enhancer sequences, intronic sequences, 5′ untranslated regions (UTRs), 3′ untranslated regions, gene modulating sequences and gene termination sequences. Such fragments are useful, for example, in controlling heterologous gene expression and in developing screens to identify gene-modulating agents.
• SNP Detection Reagents
• In a specific aspect of the present invention, the SNPs disclosed in Table 1 and/or Table 2, and their associated transcript sequences (referred to in Table 1 as SEQ ID NOS:1-51), genomic sequences (referred to in Table 2 as SEQ ID NOS:177-622), and context sequences (transcript-based context sequences are referred to in Table 1 as SEQ ID NOS:103-176; genomic-based context sequences are provided in Table 2 as SEQ ID NOS:623-3661), can be used for the design of SNP detection reagents. The actual sequences referred to in the tables are provided in the Sequence Listing. As used herein, a “SNP detection reagent” is a reagent that specifically detects a specific target SNP position disclosed herein, and that is preferably specific for a particular nucleotide (allele) of the target SNP position (i.e., the detection reagent preferably can differentiate between different alternative nucleotides at a target SNP position, thereby allowing the identity of the nucleotide present at the target SNP position to be determined). Typically, such detection reagent hybridizes to a target SNP-containing nucleic acid molecule by complementary base-pairing in a sequence specific manner, and discriminates the target variant sequence from other nucleic acid sequences such as an art-known form in a test sample. An example of a detection reagent is a probe that hybridizes to a target nucleic acid containing one or more of the SNPs referred to in Table 1 and/or Table 2. In a preferred embodiment, such a probe can differentiate between nucleic acids having a particular nucleotide (allele) at a target SNP position from other nucleic acids that have a different nucleotide at the same target SNP position. In addition, a detection reagent may hybridize to a specific region 5′ and/or 3′ to a SNP position, particularly a region corresponding to the context sequences referred to in Table 1 and/or Table 2 (transcript-based context sequences are referred to in Table 1 as SEQ ID NOS:103-176; genomic-based context sequences are referred to in Table 2 as SEQ ID NOS:623-3661). Another example of a detection reagent is a primer that acts as an initiation point of nucleotide extension along a complementary strand of a target polynucleotide. The SNP sequence information provided herein is also useful for designing primers, e.g. allele-specific primers, to amplify (e.g., using PCR) any SNP of the present invention.
• In one preferred embodiment of the invention, a SNP detection reagent is an isolated or synthetic DNA or RNA polynucleotide probe or primer or PNA oligomer, or a combination of DNA, RNA and/or PNA, that hybridizes to a segment of a target nucleic acid molecule containing a SNP identified in Table 1 and/or Table 2. A detection reagent in the form of a polynucleotide may optionally contain modified base analogs, intercalators or minor groove binders. Multiple detection reagents such as probes may be, for example, affixed to a solid support (e.g., arrays or beads) or supplied in solution (e.g. probe/primer sets for enzymatic reactions such as PCR, RT-PCR, TaqMan assays, or primer-extension reactions) to form a SNP detection kit.
• A probe or primer typically is a substantially purified oligonucleotide or PNA oligomer. Such oligonucleotide typically comprises a region of complementary nucleotide sequence that hybridizes under stringent conditions to at least about 8, 10, 12, 16, 18, 20, 22, 25, 30, 40, 50, 55, 60, 65, 70, 80, 90, 100, 120 (or any other number in-between) or more consecutive nucleotides in a target nucleic acid molecule. Depending on the particular assay, the consecutive nucleotides can either include the target SNP position, or be a specific region in close enough proximity 5′ and/or 3′ to the SNP position to carry out the desired assay.
• Other preferred primer and probe sequences can readily be determined using the transcript sequences (SEQ ID NOS:1-51), genomic sequences (SEQ ID NOS:177-622), and SNP context sequences (transcript-based context sequences are referred to in Table 1 as SEQ ID NOS:103-176; genomic-based context sequences are referred to in Table 2 as SEQ ID NOS:623-3661) disclosed in the Sequence Listing and in Tables 1 and 2. The actual sequences referred to in the tables are provided in the Sequence Listing. It will be apparent to one of skill in the art that such primers and probes are directly useful as reagents for genotyping the SNPs of the present invention, and can be incorporated into any kit/system format.
• In order to produce a probe or primer specific for a target SNP-containing sequence, the gene/transcript and/or context sequence surrounding the SNP of interest is typically examined using a computer algorithm that starts at the 5′ or at the 3′ end of the nucleotide sequence. Typical algorithms will then identify oligomers of defined length that are unique to the gene/SNP context sequence, have a GC content within a range suitable for hybridization, lack predicted secondary structure that may interfere with hybridization, and/or possess other desired characteristics or that lack other undesired characteristics.
• A primer or probe of the present invention is typically at least about 8 nucleotides in length. In one embodiment of the invention, a primer or a probe is at least about 10 nucleotides in length. In a preferred embodiment, a primer or a probe is at least about 12 nucleotides in length. In a more preferred embodiment, a primer or probe is at least about 16, 17, 18, 19, 20, 21, 22, 23, 24 or 25 nucleotides in length. While the maximal length of a probe can be as long as the target sequence to be detected, depending on the type of assay in which it is employed, it is typically less than about 50, 60, 65, or 70 nucleotides in length. In the case of a primer, it is typically less than about 30 nucleotides in length. In a specific preferred embodiment of the invention, a primer or a probe is within the length of about 18 and about 28 nucleotides. However, in other embodiments, such as nucleic acid arrays and other embodiments in which probes are affixed to a substrate, the probes can be longer, such as on the order of 30-70, 75, 80, 90, 100, or more nucleotides in length (see the section below entitled “SNP Detection Kits and Systems”).
• For analyzing SNPs, it may be appropriate to use oligonucleotides specific for alternative SNP alleles. Such oligonucleotides that detect single nucleotide variations in target sequences may be referred to by such terms as “allele-specific oligonucleotides,” “allele-specific probes,” or “allele-specific primers.” The design and use of allele-specific probes for analyzing polymorphisms is described in, e.g., Mutation Detection: A Practical Approach, Cotton et al., eds., Oxford University Press (1998); Saiki et al., Nature 324:163-166 (1986); Dattagupta, EP235,726; and Saiki, WO 89/11548.
• While the design of each allele-specific primer or probe depends on variables such as the precise composition of the nucleotide sequences flanking a SNP position in a target nucleic acid molecule, and the length of the primer or probe, another factor in the use of primers and probes is the stringency of the condition under which the hybridization between the probe or primer and the target sequence is performed. Higher stringency conditions utilize buffers with lower ionic strength and/or a higher reaction temperature, and tend to require a more perfect match between probe/primer and a target sequence in order to form a stable duplex. If the stringency is too high, however, hybridization may not occur at all. In contrast, lower stringency conditions utilize buffers with higher ionic strength and/or a lower reaction temperature, and permit the formation of stable duplexes with more mismatched bases between a probe/primer and a target sequence. By way of example and not limitation, exemplary conditions for high stringency hybridization conditions using an allele-specific probe are as follows: prehybridization with a solution containing 5× standard saline phosphate EDTA (SSPE), 0.5% NaDodSO₄ (SDS) at 55° C., and incubating probe with target nucleic acid molecules in the same solution at the same temperature, followed by washing with a solution containing 2×SSPE, and 0.1% SDS at 55° C. or room temperature.
• Moderate stringency hybridization conditions may be used for allele-specific primer extension reactions with a solution containing, e.g., about 50 mM KCl at about 46° C. Alternatively, the reaction may be carried out at an elevated temperature such as 60° C. In another embodiment, a moderately stringent hybridization condition suitable for oligonucleotide ligation assay (OLA) reactions wherein two probes are ligated if they are completely complementary to the target sequence may utilize a solution of about 100 mM KCl at a temperature of 46° C.
• In a hybridization-based assay, allele-specific probes can be designed that hybridize to a segment of target DNA from one individual but do not hybridize to the corresponding segment from another individual due to the presence of different polymorphic forms (e.g., alternative SNP alleles/nucleotides) in the respective DNA segments from the two individuals. Hybridization conditions should be sufficiently stringent that there is a significant detectable difference in hybridization intensity between alleles, and preferably an essentially binary response, whereby a probe hybridizes to only one of the alleles or significantly more strongly to one allele. While a probe may be designed to hybridize to a target sequence that contains a SNP site such that the SNP site aligns anywhere along the sequence of the probe, the probe is preferably designed to hybridize to a segment of the target sequence such that the SNP site aligns with a central position of the probe (e.g., a position within the probe that is at least three nucleotides from either end of the probe). This design of probe generally achieves good discrimination in hybridization between different allelic forms.
• In another embodiment, a probe or primer may be designed to hybridize to a segment of target DNA such that the SNP aligns with either the 5′ most end or the 3′ most end of the probe or primer. In a specific preferred embodiment that is particularly suitable for use in a oligonucleotide ligation assay (U.S. Pat. No. 4,988,617), the 3′ most nucleotide of the probe aligns with the SNP position in the target sequence.
• Oligonucleotide probes and primers may be prepared by methods well known in the art. Chemical synthetic methods include, but are not limited to, the phosphotriester method described by Narang et al., Methods in Enzymology 68:90 (1979); the phosphodiester method described by Brown et al., Methods in Enzymology 68:109 (1979); the diethylphosphoamidate method described by Beaucage et al., Tetrahedron Letters 22:1859 (1981); and the solid support method described in U.S. Pat. No. 4,458,066.
• Allele-specific probes are often used in pairs (or, less commonly, in sets of 3 or 4, such as if a SNP position is known to have 3 or 4 alleles, respectively, or to assay both strands of a nucleic acid molecule for a target SNP allele), and such pairs may be identical except for a one nucleotide mismatch that represents the allelic variants at the SNP position. Commonly, one member of a pair perfectly matches a reference form of a target sequence that has a more common SNP allele (i.e., the allele that is more frequent in the target population) and the other member of the pair perfectly matches a form of the target sequence that has a less common SNP allele (i.e., the allele that is rarer in the target population). In the case of an array, multiple pairs of probes can be immobilized on the same support for simultaneous analysis of multiple different polymorphisms.
• In one type of PCR-based assay, an allele-specific primer hybridizes to a region on a target nucleic acid molecule that overlaps a SNP position and only primes amplification of an allelic form to which the primer exhibits perfect complementarity. Gibbs, Nucleic Acid Res 17:2427-2448 (1989). Typically, the primer's 3′-most nucleotide is aligned with and complementary to the SNP position of the target nucleic acid molecule. This primer is used in conjunction with a second primer that hybridizes at a distal site. Amplification proceeds from the two primers, producing a detectable product that indicates which allelic form is present in the test sample. A control is usually performed with a second pair of primers, one of which shows a single base mismatch at the polymorphic site and the other of which exhibits perfect complementarity to a distal site. The single-base mismatch prevents amplification or substantially reduces amplification efficiency, so that either no detectable product is formed or it is formed in lower amounts or at a slower pace. The method generally works most effectively when the mismatch is at the 3′-most position of the oligonucleotide (i.e., the 3′-most position of the oligonucleotide aligns with the target SNP position) because this position is most destabilizing to elongation from the primer (see, e.g., WO 93/22456). This PCR-based assay can be utilized as part of the TaqMan assay, described below.
• In a specific embodiment of the invention, a primer of the invention contains a sequence substantially complementary to a segment of a target SNP-containing nucleic acid molecule except that the primer has a mismatched nucleotide in one of the three nucleotide positions at the 3′-most end of the primer, such that the mismatched nucleotide does not base pair with a particular allele at the SNP site. In a preferred embodiment, the mismatched nucleotide in the primer is the second from the last nucleotide at the 3′-most position of the primer. In a more preferred embodiment, the mismatched nucleotide in the primer is the last nucleotide at the 3′-most position of the primer.
• In another embodiment of the invention, a SNP detection reagent of the invention is labeled with a fluorogenic reporter dye that emits a detectable signal. While the preferred reporter dye is a fluorescent dye, any reporter dye that can be attached to a detection reagent such as an oligonucleotide probe or primer is suitable for use in the invention. Such dyes include, but are not limited to, Acridine, AMCA, BODIPY, Cascade Blue, Cy2, Cy3, Cy5, Cy7, Dabcyl, Edans, Eosin, Erythrosin, Fluorescein, 6-Fam, Tet, Joe, Hex, Oregon Green, Rhodamine, Rhodol Green, Tamra, Rox, and Texas Red.
• In yet another embodiment of the invention, the detection reagent may be further labeled with a quencher dye such as Tamra, especially when the reagent is used as a self-quenching probe such as a TaqMan (U.S. Pat. Nos. 5,210,015 and 5,538,848) or Molecular Beacon probe (U.S. Pat. Nos. 5,118,801 and 5,312,728), or other stemless or linear beacon probe (Livak et al., PCR Method Appl 4:357-362 (1995); Tyagi et al., Nature Biotechnology 14:303-308 (1996); Nazarenko et al., Nucl Acids Res 25:2516-2521 (1997); U.S. Pat. Nos. 5,866,336 and 6,117,635.
• The detection reagents of the invention may also contain other labels, including but not limited to, biotin for streptavidin binding, hapten for antibody binding, and oligonucleotide for binding to another complementary oligonucleotide such as pairs of zipcodes.
• The present invention also contemplates reagents that do not contain (or that are complementary to) a SNP nucleotide identified herein but that are used to assay one or more SNPs disclosed herein. For example, primers that flank, but do not hybridize directly to a target SNP position provided herein are useful in primer extension reactions in which the primers hybridize to a region adjacent to the target SNP position (i.e., within one or more nucleotides from the target SNP site). During the primer extension reaction, a primer is typically not able to extend past a target SNP site if a particular nucleotide (allele) is present at that target SNP site, and the primer extension product can be detected in order to determine which SNP allele is present at the target SNP site. For example, particular ddNTPs are typically used in the primer extension reaction to terminate primer extension once a ddNTP is incorporated into the extension product (a primer extension product which includes a ddNTP at the 3′-most end of the primer extension product, and in which the ddNTP is a nucleotide of a SNP disclosed herein, is a composition that is specifically contemplated by the present invention). Thus, reagents that bind to a nucleic acid molecule in a region adjacent to a SNP site and that are used for assaying the SNP site, even though the bound sequences do not necessarily include the SNP site itself, are also contemplated by the present invention.
• SNP Detection Kits and Systems
• A person skilled in the art will recognize that, based on the SNP and associated sequence information disclosed herein, detection reagents can be developed and used to assay any SNP of the present invention individually or in combination, and such detection reagents can be readily incorporated into one of the established kit or system formats which are well known in the art. The terms “kits” and “systems,” as used herein in the context of SNP detection reagents, are intended to refer to such things as combinations of multiple SNP detection reagents, or one or more SNP detection reagents in combination with one or more other types of elements or components (e.g., other types of biochemical reagents, containers, packages such as packaging intended for commercial sale, substrates to which SNP detection reagents are attached, electronic hardware components, etc.). Accordingly, the present invention further provides SNP detection kits and systems, including but not limited to, packaged probe and primer sets (e.g. TaqMan probe/primer sets), arrays/microarrays of nucleic acid molecules, and beads that contain one or more probes, primers, or other detection reagents for detecting one or more SNPs of the present invention. The kits/systems can optionally include various electronic hardware components; for example, arrays (“DNA chips”) and microfluidic systems (“lab-on-a-chip” systems) provided by various manufacturers typically comprise hardware components. Other kits/systems (e.g., probe/primer sets) may not include electronic hardware components, but may be comprised of, for example, one or more SNP detection reagents (along with, optionally, other biochemical reagents) packaged in one or more containers.
• In some embodiments, a SNP detection kit typically contains one or more detection reagents and other components (e.g. a buffer, enzymes such as DNA polymerases or ligases, chain extension nucleotides such as deoxynucleotide triphosphates, and in the case of Sanger-type DNA sequencing reactions, chain terminating nucleotides, positive control sequences, negative control sequences, and the like) necessary to carry out an assay or reaction, such as amplification and/or detection of a SNP-containing nucleic acid molecule. A kit may further contain means for determining the amount of a target nucleic acid, and means for comparing the amount with a standard, and can comprise instructions for using the kit to detect the SNP-containing nucleic acid molecule of interest. In one embodiment of the present invention, kits are provided which contain the necessary reagents to carry out one or more assays to detect one or more SNPs disclosed herein. In a preferred embodiment of the present invention, SNP detection kits/systems are in the form of nucleic acid arrays, or compartmentalized kits, including microfluidic/lab-on-a-chip systems.
• Exemplary kits of the invention can comprise a container containing a SNP detection reagent which detects a SNP disclosed herein, said container can optionally be enclosed in a package (e.g., a box for commercial sale), and said package can further include other containers containing any or all of the following: enzyme (e.g., polymerase or ligase, any of which can be thermostable), dNTPs and/or ddNTPs (which can optionally be detectably labeled, such as with a fluorescent label or mass tag, and such label can optionally differ between any of the dATPs, dCTPs, dGTPs, dTTPs, ddATPs, ddCTPs, ddGTPs, and/or ddTTPs, so that each of these dNTPs and/or ddNTPs can be distinguished from each other by detection of the label, and any of these dNTPs and/or ddNTPs can optionally be stored in the same container or each in separate containers), buffer, controls (e.g., positive control nucleic acid, or a negative control), reagent(s) for extracting nucleic acid from a test sample, and instructions for using the kit (such as instructions for correlating the presence or absence of a particular allele or genotype with an increased or decreased risk for disease such as CVD, or an increased or decreased likelihood of responding to a drug such as a statin). The SNP detection reagent can comprise, for example, at least one primer and/or probe, any of which can optionally be allele-specific, and any of which can optionally be detectably labeled (e.g., with a fluorescent label).
• SNP detection kits/systems may contain, for example, one or more probes, or pairs of probes, that hybridize to a nucleic acid molecule at or near each target SNP position. Multiple pairs of allele-specific probes may be included in the kit/system to simultaneously assay large numbers of SNPs, at least one of which is a SNP of the present invention. In some kits/systems, the allele-specific probes are immobilized to a substrate such as an array or bead. For example, the same substrate can comprise allele-specific probes for detecting at least 1; 10; 100; 1000; 10,000; 100,000 (or any other number in-between) or substantially all of the SNPs shown in Table 1 and/or Table 2.
• The terms “arrays,” “microarrays,” and “DNA chips” are used herein interchangeably to refer to an array of distinct polynucleotides affixed to a substrate, such as glass, plastic, paper, nylon or other type of membrane, filter, chip, or any other suitable solid support. The polynucleotides can be synthesized directly on the substrate, or synthesized separate from the substrate and then affixed to the substrate. In one embodiment, the microarray is prepared and used according to the methods described in Chee et al., U.S. Pat. No. 5,837,832 and PCT application WO95/11995; D. J. Lockhart et al., Nat Biotech 14:1675-1680 (1996); and M. Schena et al., Proc Natl Acad Sci 93:10614-10619 (1996), all of which are incorporated herein in their entirety by reference. In other embodiments, such arrays are produced by the methods described by Brown et al., U.S. Pat. No. 5,807,522.
• Nucleic acid arrays are reviewed in the following references: Zammatteo et al., “New chips for molecular biology and diagnostics,” Biotechnol Annu Rev 8:85-101 (2002); Sosnowski et al., “Active microelectronic array system for DNA hybridization, genotyping and pharmacogenomic applications,” Psychiatr Genet 12(4):181-92 (December 2002); Heller, “DNA microarray technology: devices, systems, and applications,” Annu Rev Biomed Eng 4:129-53 (2002); Epub Mar. 22, 2002; Kolchinsky et al., “Analysis of SNPs and other genomic variations using gel-based chips,” Hum Mutat 19(4):343-60 (April 2002); and McGall et al., “High-density genechip oligonucleotide probe arrays,” Adv Biochem Eng Biotechnol 77:21-42 (2002).
• Any number of probes, such as allele-specific probes, may be implemented in an array, and each probe or pair of probes can hybridize to a different SNP position. In the case of polynucleotide probes, they can be synthesized at designated areas (or synthesized separately and then affixed to designated areas) on a substrate using a light-directed chemical process. Each DNA chip can contain, for example, thousands to millions of individual synthetic polynucleotide probes arranged in a grid-like pattern and miniaturized (e.g., to the size of a dime). Preferably, probes are attached to a solid support in an ordered, addressable array.
• A microarray can be composed of a large number of unique, single-stranded polynucleotides, usually either synthetic antisense polynucleotides or fragments of cDNAs, fixed to a solid support. Typical polynucleotides are preferably about 6-60 nucleotides in length, more preferably about 15-30 nucleotides in length, and most preferably about 18-25 nucleotides in length. For certain types of microarrays or other detection kits/systems, it may be preferable to use oligonucleotides that are only about 7-20 nucleotides in length. In other types of arrays, such as arrays used in conjunction with chemiluminescent detection technology, preferred probe lengths can be, for example, about 15-80 nucleotides in length, preferably about 50-70 nucleotides in length, more preferably about 55-65 nucleotides in length, and most preferably about 60 nucleotides in length. The microarray or detection kit can contain polynucleotides that cover the known 5′ or 3′ sequence of a gene/transcript or target SNP site, sequential polynucleotides that cover the full-length sequence of a gene/transcript; or unique polynucleotides selected from particular areas along the length of a target gene/transcript sequence, particularly areas corresponding to one or more SNPs disclosed in Table 1 and/or Table 2. Polynucleotides used in the microarray or detection kit can be specific to a SNP or SNPs of interest (e.g., specific to a particular SNP allele at a target SNP site, or specific to particular SNP alleles at multiple different SNP sites), or specific to a polymorphic gene/transcript or genes/transcripts of interest.
• Hybridization assays based on polynucleotide arrays rely on the differences in hybridization stability of the probes to perfectly matched and mismatched target sequence variants. For SNP genotyping, it is generally preferable that stringency conditions used in hybridization assays are high enough such that nucleic acid molecules that differ from one another at as little as a single SNP position can be differentiated (e.g., typical SNP hybridization assays are designed so that hybridization will occur only if one particular nucleotide is present at a SNP position, but will not occur if an alternative nucleotide is present at that SNP position). Such high stringency conditions may be preferable when using, for example, nucleic acid arrays of allele-specific probes for SNP detection. Such high stringency conditions are described in the preceding section, and are well known to those skilled in the art and can be found in, for example, Current Protocols in Molecular Biology 6.3.1-6.3.6, John Wiley & Sons, N.Y. (1989).
• In other embodiments, the arrays are used in conjunction with chemiluminescent detection technology. The following patents and patent applications, which are all hereby incorporated by reference, provide additional information pertaining to chemiluminescent detection. U.S. patent applications that describe chemiluminescent approaches for microarray detection: Ser. Nos. 10/620,332 and 10/620,333. U.S. patents that describe methods and compositions of dioxetane for performing chemiluminescent detection: U.S. Pat. Nos. 6,124,478; 6,107,024; 5,994,073; 5,981,768; 5,871,938; 5,843,681; 5,800,999 and 5,773,628. And the U.S. published application that discloses methods and compositions for microarray controls: US2002/0110828.
• In one embodiment of the invention, a nucleic acid array can comprise an array of probes of about 15-25 nucleotides in length. In further embodiments, a nucleic acid array can comprise any number of probes, in which at least one probe is capable of detecting one or more SNPs disclosed in Table 1 and/or Table 2, and/or at least one probe comprises a fragment of one of the sequences selected from the group consisting of those disclosed in Table 1, Table 2, the Sequence Listing, and sequences complementary thereto, said fragment comprising at least about 8 consecutive nucleotides, preferably 10, 12, 15, 16, 18, 20, more preferably 22, 25, 30, 40, 47, 50, 55, 60, 65, 70, 80, 90, 100, or more consecutive nucleotides (or any other number in-between) and containing (or being complementary to) a novel SNP allele disclosed in Table 1 and/or Table 2. In some embodiments, the nucleotide complementary to the SNP site is within 5, 4, 3, 2, or 1 nucleotide from the center of the probe, more preferably at the center of said probe.
• A polynucleotide probe can be synthesized on the surface of the substrate by using a chemical coupling procedure and an ink jet application apparatus, as described in PCT application WO95/251116 (Baldeschweiler et al.) which is incorporated herein in its entirety by reference. In another aspect, a “gridded” array analogous to a dot (or slot) blot may be used to arrange and link cDNA fragments or oligonucleotides to the surface of a substrate using a vacuum system, thermal, UV, mechanical or chemical bonding procedures. An array, such as those described above, may be produced by hand or by using available devices (slot blot or dot blot apparatus), materials (any suitable solid support), and machines (including robotic instruments), and may contain 8, 24, 96, 384, 1536, 6144 or more polynucleotides, or any other number which lends itself to the efficient use of commercially available instrumentation.
• Using such arrays or other kits/systems, the present invention provides methods of identifying the SNPs disclosed herein in a test sample. Such methods typically involve incubating a test sample of nucleic acids with an array comprising one or more probes corresponding to at least one SNP position of the present invention, and assaying for binding of a nucleic acid from the test sample with one or more of the probes. Conditions for incubating a SNP detection reagent (or a kit/system that employs one or more such SNP detection reagents) with a test sample vary. Incubation conditions depend on such factors as the format employed in the assay, the detection methods employed, and the type and nature of the detection reagents used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification and array assay formats can readily be adapted to detect the SNPs disclosed herein.
• A SNP detection kit/system of the present invention may include components that are used to prepare nucleic acids from a test sample for the subsequent amplification and/or detection of a SNP-containing nucleic acid molecule. Such sample preparation components can be used to produce nucleic acid extracts (including DNA and/or RNA), proteins or membrane extracts from any bodily fluids (such as blood, serum, plasma, urine, saliva, phlegm, gastric juices, semen, tears, sweat, etc.), skin, hair, cells (especially nucleated cells) such as buccal cells (e.g., as obtained by buccal swabs), biopsies, or tissue specimens. The test samples used in the above-described methods will vary based on such factors as the assay format, nature of the detection method, and the specific tissues, cells or extracts used as the test sample to be assayed. Methods of preparing nucleic acids, proteins, and cell extracts are well known in the art and can be readily adapted to obtain a sample that is compatible with the system utilized. Automated sample preparation systems for extracting nucleic acids from a test sample are commercially available, and examples are Qiagen's BioRobot 9600, Applied Biosystems' PRISM™ 6700 sample preparation system, and Roche Molecular Systems' COBAS AmpliPrep System.
• Another form of kit contemplated by the present invention is a compartmentalized kit. A compartmentalized kit includes any kit in which reagents are contained in separate containers. Such containers include, for example, small glass containers, plastic containers, strips of plastic, glass or paper, or arraying material such as silica. Such containers allow one to efficiently transfer reagents from one compartment to another compartment such that the test samples and reagents are not cross-contaminated, or from one container to another vessel not included in the kit, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another or to another vessel. Such containers may include, for example, one or more containers which will accept the test sample, one or more containers which contain at least one probe or other SNP detection reagent for detecting one or more SNPs of the present invention, one or more containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and one or more containers which contain the reagents used to reveal the presence of the bound probe or other SNP detection reagents. The kit can optionally further comprise compartments and/or reagents for, for example, nucleic acid amplification or other enzymatic reactions such as primer extension reactions, hybridization, ligation, electrophoresis (preferably capillary electrophoresis), mass spectrometry, and/or laser-induced fluorescent detection. The kit may also include instructions for using the kit. Exemplary compartmentalized kits include microfluidic devices known in the art. See, e.g., Weigl et al., “Lab-on-a-chip for drug development,” Adv Drug Deliv Rev 55(3):349-77 (February 2003). In such microfluidic devices, the containers may be referred to as, for example, microfluidic “compartments,” “chambers,” or “channels.”
• Microfluidic devices, which may also be referred to as “lab-on-a-chip” systems, biomedical micro-electro-mechanical systems (bioMEMs), or multicomponent integrated systems, are exemplary kits/systems of the present invention for analyzing SNPs. Such systems miniaturize and compartmentalize processes such as probe/target hybridization, nucleic acid amplification, and capillary electrophoresis reactions in a single functional device. Such microfluidic devices typically utilize detection reagents in at least one aspect of the system, and such detection reagents may be used to detect one or more SNPs of the present invention. One example of a microfluidic system is disclosed in U.S. Pat. No. 5,589,136, which describes the integration of PCR amplification and capillary electrophoresis in chips. Exemplary microfluidic systems comprise a pattern of microchannels designed onto a glass, silicon, quartz, or plastic wafer included on a microchip. The movements of the samples may be controlled by electric, electroosmotic or hydrostatic forces applied across different areas of the microchip to create functional microscopic valves and pumps with no moving parts. Varying the voltage can be used as a means to control the liquid flow at intersections between the micro-machined channels and to change the liquid flow rate for pumping across different sections of the microchip. See, for example, U.S. Pat. No. 6,153,073, Dubrow et al., and U.S. Pat. No. 6,156,181, Parce et al.
• For genotyping SNPs, an exemplary microfluidic system may integrate, for example, nucleic acid amplification, primer extension, capillary electrophoresis, and a detection method such as laser induced fluorescence detection. In a first step of an exemplary process for using such an exemplary system, nucleic acid samples are amplified, preferably by PCR. Then, the amplification products are subjected to automated primer extension reactions using ddNTPs (specific fluorescence for each ddNTP) and the appropriate oligonucleotide primers to carry out primer extension reactions which hybridize just upstream of the targeted SNP. Once the extension at the 3′ end is completed, the primers are separated from the unincorporated fluorescent ddNTPs by capillary electrophoresis. The separation medium used in capillary electrophoresis can be, for example, polyacrylamide, polyethyleneglycol or dextran. The incorporated ddNTPs in the single nucleotide primer extension products are identified by laser-induced fluorescence detection. Such an exemplary microchip can be used to process, for example, at least 96 to 384 samples, or more, in parallel.
• Uses of Nucleic Acid Molecules
• The nucleic acid molecules of the present invention have a variety of uses, particularly for predicting whether an individual will benefit from statin treatment by reducing their risk for CVD (particularly CHD, such as MI) in response to the statin treatment, as well as for the diagnosis, prognosis, treatment, and prevention of CVD (particularly CHD, such as MI). For example, the nucleic acid molecules of the invention are useful for determining the likelihood of an individual who currently or previously has or has had CVD (such as an individual who has previously had an MI) or who is at increased risk for developing CVD (such as an individual who has not yet had an MI but is at increased risk for having an MI in the future) of responding to treatment (or prevention) of CVD with statins (such as by reducing their risk of developing primary or recurrent CVD, such as MI, in the future), predicting the likelihood that the individual will experience toxicity or other undesirable side effects from the statin treatment, predicting an individual's risk for developing CVD (particularly the risk for CHD such as MI), etc. For example, the nucleic acid molecules are useful as hybridization probes, such as for genotyping SNPs in messenger RNA, transcript, cDNA, genomic DNA, amplified DNA or other nucleic acid molecules, and for isolating full-length cDNA and genomic clones encoding the variant peptides disclosed in Table 1 as well as their orthologs.
• A probe can hybridize to any nucleotide sequence along the entire length of a nucleic acid molecule referred to in Table 1 and/or Table 2. Preferably, a probe of the present invention hybridizes to a region of a target sequence that encompasses a SNP position indicated in Table 1 and/or Table 2. More preferably, a probe hybridizes to a SNP-containing target sequence in a sequence-specific manner such that it distinguishes the target sequence from other nucleotide sequences which vary from the target sequence only by which nucleotide is present at the SNP site. Such a probe is particularly useful for detecting the presence of a SNP-containing nucleic acid in a test sample, or for determining which nucleotide (allele) is present at a particular SNP site (i.e., genotyping the SNP site).
• A nucleic acid hybridization probe may be used for determining the presence, level, form, and/or distribution of nucleic acid expression. The nucleic acid whose level is determined can be DNA or RNA. Accordingly, probes specific for the SNPs described herein can be used to assess the presence, expression and/or gene copy number in a given cell, tissue, or organism. These uses are relevant for diagnosis of disorders involving an increase or decrease in gene expression relative to normal levels. In vitro techniques for detection of mRNA include, for example, Northern blot hybridizations and in situ hybridizations. In vitro techniques for detecting DNA include Southern blot hybridizations and in situ hybridizations. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, N.Y. (2000).
• Probes can be used as part of a diagnostic test kit for identifying cells or tissues in which a variant protein is expressed, such as by measuring the level of a variant protein-encoding nucleic acid (e.g., mRNA) in a sample of cells from a subject or determining if a polynucleotide contains a SNP of interest.
• Thus, the nucleic acid molecules of the invention can be used as hybridization probes to detect the SNPs disclosed herein, thereby determining the likelihood that an individual will respond positively to statin treatment for reducing the risk of CVD (particularly CHD such as MI), or whether an individual with the polymorphism(s) is at risk for developing CVD (or has already developed early stage CVD). Detection of a SNP associated with a disease phenotype provides a diagnostic tool for an active disease and/or genetic predisposition to the disease.
• Furthermore, the nucleic acid molecules of the invention are therefore useful for detecting a gene (gene information is disclosed in Table 2, for example) which contains a SNP disclosed herein and/or products of such genes, such as expressed mRNA transcript molecules (transcript information is disclosed in Table 1, for example), and are thus useful for detecting gene expression. The nucleic acid molecules can optionally be implemented in, for example, an array or kit format for use in detecting gene expression.
• The nucleic acid molecules of the invention are also useful as primers to amplify any given region of a nucleic acid molecule, particularly a region containing a SNP identified in Table 1 and/or Table 2.
• The nucleic acid molecules of the invention are also useful for constructing recombinant vectors (described in greater detail below). Such vectors include expression vectors that express a portion of, or all of, any of the variant peptide sequences referred to in Table 1. Vectors also include insertion vectors, used to integrate into another nucleic acid molecule sequence, such as into the cellular genome, to alter in situ expression of a gene and/or gene product. For example, an endogenous coding sequence can be replaced via homologous recombination with all or part of the coding region containing one or more specifically introduced SNPs.
• The nucleic acid molecules of the invention are also useful for expressing antigenic portions of the variant proteins, particularly antigenic portions that contain a variant amino acid sequence (e.g., an amino acid substitution) caused by a SNP disclosed in Table 1 and/or Table 2.
• The nucleic acid molecules of the invention are also useful for constructing vectors containing a gene regulatory region of the nucleic acid molecules of the present invention.
• The nucleic acid molecules of the invention are also useful for designing ribozymes corresponding to all, or a part, of an mRNA molecule expressed from a SNP-containing nucleic acid molecule described herein.
• The nucleic acid molecules of the invention are also useful for constructing host cells expressing a part, or all, of the nucleic acid molecules and variant peptides.
• The nucleic acid molecules of the invention are also useful for constructing transgenic animals expressing all, or a part, of the nucleic acid molecules and variant peptides. The production of recombinant cells and transgenic animals having nucleic acid molecules which contain the SNPs disclosed in Table 1 and/or Table 2 allows, for example, effective clinical design of treatment compounds and dosage regimens.
• The nucleic acid molecules of the invention are also useful in assays for drug screening to identify compounds that, for example, modulate nucleic acid expression.
• The nucleic acid molecules of the invention are also useful in gene therapy in patients whose cells have aberrant gene expression. Thus, recombinant cells, which include a patient's cells that have been engineered ex vivo and returned to the patient, can be introduced into an individual where the recombinant cells produce the desired protein to treat the individual.
• SNP Genotyping Methods
• The process of determining which nucleotide(s) is/are present at each of one or more SNP positions (such as a SNP position disclosed in Table 1 and/or Table 2), for either or both alleles, may be referred to by such phrases as SNP genotyping, determining the “identity” of a SNP, determining the “content” of a SNP, or determining which nucleotide(s)/allele(s) is/are present at a SNP position. Thus, these terms can refer to detecting a single allele (nucleotide) at a SNP position or can encompass detecting both alleles (nucleotides) at a SNP position (such as to determine the homozygous or heterozygous state of a SNP position). Furthermore, these terms may also refer to detecting an amino acid residue encoded by a SNP (such as alternative amino acid residues that are encoded by different codons created by alternative nucleotides at a missense SNP position, for example).
• The present invention provides methods of SNP genotyping, such as for use in implementing a preventive or treatment regimen for an individual based on that individual having an increased susceptibility for developing CVD (e.g., increased risk for CHD, such as MI) and/or an increased likelihood of benefiting from statin treatment for reducing the risk of CVD, in evaluating an individual's likelihood of responding to statin treatment (particularly for treating or preventing CVD), in selecting a treatment or preventive regimen (e.g., in deciding whether or not to administer statin treatment to an individual having CVD, or who is at increased risk for developing CVD, such as MI, in the future), or in formulating or selecting a particular statin-based treatment or preventive regimen such as dosage and/or frequency of administration of statin treatment or choosing which form/type of statin to be administered, such as a particular pharmaceutical composition or compound, etc.), determining the likelihood of experiencing toxicity or other undesirable side effects from statin treatment, or selecting individuals for a clinical trial of a statin (e.g., selecting individuals to participate in the trial who are most likely to respond positively from the statin treatment and/or excluding individuals from the trial who are unlikely to respond positively from the statin treatment based on their SNP genotype(s), or selecting individuals who are unlikely to respond positively to statins based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them), etc. The SNP genotyping methods of the invention can also be useful for evaluating an individual's risk for developing CVD (particularly CHD, such as MI) and for predicting the likelihood that an individual who has previously had CVD will have a recurrence of CVD again in the future (e.g., recurrent MI).
• Nucleic acid samples can be genotyped to determine which allele(s) is/are present at any given genetic region (e.g., SNP position) of interest by methods well known in the art. The neighboring sequence can be used to design SNP detection reagents such as oligonucleotide probes, which may optionally be implemented in a kit format. Exemplary SNP genotyping methods are described in Chen et al., “Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput,” Pharmacogenomics J 3(2):77-96 (2003); Kwok et al., “Detection of single nucleotide polymorphisms,” Curr Issues Mol Biol 5(2):43-60 (April 2003); Shi, “Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes,” Am J Pharmacogenomics 2(3):197-205 (2002); and Kwok, “Methods for genotyping single nucleotide polymorphisms,” Annu Rev Genomics Hum Genet 2:235-58 (2001). Exemplary techniques for high-throughput SNP genotyping are described in Marnellos, “High-throughput SNP analysis for genetic association studies,” Curr Opin Drug Discov Devel 6(3):317-21 (May 2003). Common SNP genotyping methods include, but are not limited to, TaqMan assays, molecular beacon assays, nucleic acid arrays, allele-specific primer extension, allele-specific PCR, arrayed primer extension, homogeneous primer extension assays, primer extension with detection by mass spectrometry, pyrosequencing, multiplex primer extension sorted on genetic arrays, ligation with rolling circle amplification, homogeneous ligation, OLA (U.S. Pat. No. 4,988,167), multiplex ligation reaction sorted on genetic arrays, restriction-fragment length polymorphism, single base extension-tag assays, and the Invader assay. Such methods may be used in combination with detection mechanisms such as, for example, luminescence or chemiluminescence detection, fluorescence detection, time-resolved fluorescence detection, fluorescence resonance energy transfer, fluorescence polarization, mass spectrometry, and electrical detection.
• Various methods for detecting polymorphisms include, but are not limited to, methods in which protection from cleavage agents is used to detect mismatched bases in RNA/RNA or RNA/DNA duplexes (Myers et al., Science 230:1242 (1985); Cotton et al., PNAS 85:4397 (1988); and Saleeba et al., Meth. Enzymol 217:286-295 (1992)), comparison of the electrophoretic mobility of variant and wild type nucleic acid molecules (Orita et al., PNAS 86:2766 (1989); Cotton et al., Mutat Res 285:125-144 (1993); and Hayashi et al., Genet Anal Tech Appl 9:73-79 (1992)), and assaying the movement of polymorphic or wild-type fragments in polyacrylamide gels containing a gradient of denaturant using denaturing gradient gel electrophoresis (DGGE) (Myers et al., Nature 313:495 (1985)). Sequence variations at specific locations can also be assessed by nuclease protection assays such as RNase and S1 protection or chemical cleavage methods.
• In a preferred embodiment, SNP genotyping is performed using the TaqMan assay, which is also known as the 5′ nuclease assay (U.S. Pat. Nos. 5,210,015 and 5,538,848). The TaqMan assay detects the accumulation of a specific amplified product during PCR. The TaqMan assay utilizes an oligonucleotide probe labeled with a fluorescent reporter dye and a quencher dye. The reporter dye is excited by irradiation at an appropriate wavelength, it transfers energy to the quencher dye in the same probe via a process called fluorescence resonance energy transfer (FRET). When attached to the probe, the excited reporter dye does not emit a signal. The proximity of the quencher dye to the reporter dye in the intact probe maintains a reduced fluorescence for the reporter. The reporter dye and quencher dye may be at the 5′ most and the 3′ most ends, respectively, or vice versa. Alternatively, the reporter dye may be at the 5′ or 3′ most end while the quencher dye is attached to an internal nucleotide, or vice versa. In yet another embodiment, both the reporter and the quencher may be attached to internal nucleotides at a distance from each other such that fluorescence of the reporter is reduced.
• During PCR, the 5′ nuclease activity of DNA polymerase cleaves the probe, thereby separating the reporter dye and the quencher dye and resulting in increased fluorescence of the reporter. Accumulation of PCR product is detected directly by monitoring the increase in fluorescence of the reporter dye. The DNA polymerase cleaves the probe between the reporter dye and the quencher dye only if the probe hybridizes to the target SNP-containing template which is amplified during PCR, and the probe is designed to hybridize to the target SNP site only if a particular SNP allele is present.
• Preferred TaqMan primer and probe sequences can readily be determined using the SNP and associated nucleic acid sequence information provided herein. A number of computer programs, such as Primer Express (Applied Biosystems, Foster City, Calif.), can be used to rapidly obtain optimal primer/probe sets. It will be apparent to one of skill in the art that such primers and probes for detecting the SNPs of the present invention are useful in, for example, screening individuals for their likelihood of responding to statin treatment (i.e., benefiting from statin treatment), particularly individuals who have or are susceptible to CVD (particularly CHD, such as MI), or in screening for individuals who are susceptible to developing CVD. These probes and primers can be readily incorporated into a kit format. The present invention also includes modifications of the Taqman assay well known in the art such as the use of Molecular Beacon probes (U.S. Pat. Nos. 5,118,801 and 5,312,728) and other variant formats (U.S. Pat. Nos. 5,866,336 and 6,117,635).
• Another preferred method for genotyping the SNPs of the present invention is the use of two oligonucleotide probes in an OLA (see, e.g., U.S. Pat. No. 4,988,617). In this method, one probe hybridizes to a segment of a target nucleic acid with its 3′ most end aligned with the SNP site. A second probe hybridizes to an adjacent segment of the target nucleic acid molecule directly 3′ to the first probe. The two juxtaposed probes hybridize to the target nucleic acid molecule, and are ligated in the presence of a linking agent such as a ligase if there is perfect complementarity between the 3′ most nucleotide of the first probe with the SNP site. If there is a mismatch, ligation would not occur. After the reaction, the ligated probes are separated from the target nucleic acid molecule, and detected as indicators of the presence of a SNP.
• The following patents, patent applications, and published international patent applications, which are all hereby incorporated by reference, provide additional information pertaining to techniques for carrying out various types of OLA. The following U.S. patents describe OLA strategies for performing SNP detection: U.S. Pat. Nos. 6,027,889; 6,268,148; 5,494,810; 5,830,711 and 6,054,564. WO 97/31256 and WO 00/56927 describe OLA strategies for performing SNP detection using universal arrays, wherein a zipcode sequence can be introduced into one of the hybridization probes, and the resulting product, or amplified product, hybridized to a universal zip code array. U.S. application US01/17329 (and Ser. No. 09/584,905) describes OLA (or LDR) followed by PCR, wherein zipcodes are incorporated into OLA probes, and amplified PCR products are determined by electrophoretic or universal zipcode array readout. U.S. applications 60/427,818, 60/445,636, and 60/445,494 describe SNPlex methods and software for multiplexed SNP detection using OLA followed by PCR, wherein zipcodes are incorporated into OLA probes, and amplified PCR products are hybridized with a zipchute reagent, and the identity of the SNP determined from electrophoretic readout of the zipchute. In some embodiments, OLA is carried out prior to PCR (or another method of nucleic acid amplification). In other embodiments, PCR (or another method of nucleic acid amplification) is carried out prior to OLA.
• Another method for SNP genotyping is based on mass spectrometry. Mass spectrometry takes advantage of the unique mass of each of the four nucleotides of DNA. SNPs can be unambiguously genotyped by mass spectrometry by measuring the differences in the mass of nucleic acids having alternative SNP alleles. MALDI-TOF (Matrix Assisted Laser Desorption Ionization-Time of Flight) mass spectrometry technology is preferred for extremely precise determinations of molecular mass, such as SNPs. Numerous approaches to SNP analysis have been developed based on mass spectrometry. Preferred mass spectrometry-based methods of SNP genotyping include primer extension assays, which can also be utilized in combination with other approaches, such as traditional gel-based formats and microarrays.
• Typically, the primer extension assay involves designing and annealing a primer to a template PCR amplicon upstream (5′) from a target SNP position. A mix of dideoxynucleotide triphosphates (ddNTPs) and/or deoxynucleotide triphosphates (dNTPs) are added to a reaction mixture containing template (e.g., a SNP-containing nucleic acid molecule which has typically been amplified, such as by PCR), primer, and DNA polymerase. Extension of the primer terminates at the first position in the template where a nucleotide complementary to one of the ddNTPs in the mix occurs. The primer can be either immediately adjacent (i.e., the nucleotide at the 3′ end of the primer hybridizes to the nucleotide next to the target SNP site) or two or more nucleotides removed from the SNP position. If the primer is several nucleotides removed from the target SNP position, the only limitation is that the template sequence between the 3′ end of the primer and the SNP position cannot contain a nucleotide of the same type as the one to be detected, or this will cause premature termination of the extension primer. Alternatively, if all four ddNTPs alone, with no dNTPs, are added to the reaction mixture, the primer will always be extended by only one nucleotide, corresponding to the target SNP position. In this instance, primers are designed to bind one nucleotide upstream from the SNP position (i.e., the nucleotide at the 3′ end of the primer hybridizes to the nucleotide that is immediately adjacent to the target SNP site on the 5′ side of the target SNP site). Extension by only one nucleotide is preferable, as it minimizes the overall mass of the extended primer, thereby increasing the resolution of mass differences between alternative SNP nucleotides. Furthermore, mass-tagged ddNTPs can be employed in the primer extension reactions in place of unmodified ddNTPs. This increases the mass difference between primers extended with these ddNTPs, thereby providing increased sensitivity and accuracy, and is particularly useful for typing heterozygous base positions. Mass-tagging also alleviates the need for intensive sample-preparation procedures and decreases the necessary resolving power of the mass spectrometer.
• The extended primers can then be purified and analyzed by MALDI-TOF mass spectrometry to determine the identity of the nucleotide present at the target SNP position. In one method of analysis, the products from the primer extension reaction are combined with light absorbing crystals that form a matrix. The matrix is then hit with an energy source such as a laser to ionize and desorb the nucleic acid molecules into the gas-phase. The ionized molecules are then ejected into a flight tube and accelerated down the tube towards a detector. The time between the ionization event, such as a laser pulse, and collision of the molecule with the detector is the time of flight of that molecule. The time of flight is precisely correlated with the mass-to-charge ratio (m/z) of the ionized molecule. Ions with smaller m/z travel down the tube faster than ions with larger m/z and therefore the lighter ions reach the detector before the heavier ions. The time-of-flight is then converted into a corresponding, and highly precise, m/z. In this manner, SNPs can be identified based on the slight differences in mass, and the corresponding time of flight differences, inherent in nucleic acid molecules having different nucleotides at a single base position. For further information regarding the use of primer extension assays in conjunction with MALDI-TOF mass spectrometry for SNP genotyping, see, e.g., Wise et al., “A standard protocol for single nucleotide primer extension in the human genome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry,” Rapid Commun Mass Spectrom 17(11):1195-202 (2003).
• The following references provide further information describing mass spectrometry-based methods for SNP genotyping: Bocker, “SNP and mutation discovery using base-specific cleavage and MALDI-TOF mass spectrometry,” Bioinformatics 19 Suppl 1:144-153 (July 2003); Storm et al., “MALDI-TOF mass spectrometry-based SNP genotyping,” Methods Mol Biol 212:241-62 (2003); Jurinke et al., “The use of Mass ARRAY technology for high throughput genotyping,” Adv Biochem Eng Biotechnol 77:57-74 (2002); and Jurinke et al., “Automated genotyping using the DNA MassArray technology,” Methods Mol Biol 187:179-92 (2002).
• SNPs can also be scored by direct DNA sequencing. A variety of automated sequencing procedures can be utilized (e.g. Biotechniques 19:448 (1995)), including sequencing by mass spectrometry. See, e.g., PCT International Publication No. WO 94/16101; Cohen et al., Adv Chromatogr 36:127-162 (1996); and Griffin et al., Appl Biochem Biotechnol 38:147-159 (1993). The nucleic acid sequences of the present invention enable one of ordinary skill in the art to readily design sequencing primers for such automated sequencing procedures. Commercial instrumentation, such as the Applied Biosystems 377, 3100, 3700, 3730, and 3730xl DNA Analyzers (Foster City, Calif.), is commonly used in the art for automated sequencing.
• Other methods that can be used to genotype the SNPs of the present invention include single-strand conformational polymorphism (SSCP), and denaturing gradient gel electrophoresis (DGGE). Myers et al., Nature 313:495 (1985). SSCP identifies base differences by alteration in electrophoretic migration of single stranded PCR products, as described in Orita et al., Proc. Nat. Acad. Single-stranded PCR products can be generated by heating or otherwise denaturing double stranded PCR products. Single-stranded nucleic acids may refold or form secondary structures that are partially dependent on the base sequence. The different electrophoretic mobilities of single-stranded amplification products are related to base-sequence differences at SNP positions. DGGE differentiates SNP alleles based on the different sequence-dependent stabilities and melting properties inherent in polymorphic DNA and the corresponding differences in electrophoretic migration patterns in a denaturing gradient gel. PCR Technology: Principles and Applications for DNA Amplification Chapter 7, Erlich, ed., W.H. Freeman and Co, N.Y. (1992).
• Sequence-specific ribozymes (U.S. Pat. No. 5,498,531) can also be used to score SNPs based on the development or loss of a ribozyme cleavage site. Perfectly matched sequences can be distinguished from mismatched sequences by nuclease cleavage digestion assays or by differences in melting temperature. If the SNP affects a restriction enzyme cleavage site, the SNP can be identified by alterations in restriction enzyme digestion patterns, and the corresponding changes in nucleic acid fragment lengths determined by gel electrophoresis.
• SNP genotyping can include the steps of, for example, collecting a biological sample from a human subject (e.g., sample of tissues, cells, fluids, secretions, etc.), isolating nucleic acids (e.g., genomic DNA, mRNA or both) from the cells of the sample, contacting the nucleic acids with one or more primers which specifically hybridize to a region of the isolated nucleic acid containing a target SNP under conditions such that hybridization and amplification of the target nucleic acid region occurs, and determining the nucleotide present at the SNP position of interest, or, in some assays, detecting the presence or absence of an amplification product (assays can be designed so that hybridization and/or amplification will only occur if a particular SNP allele is present or absent). In some assays, the size of the amplification product is detected and compared to the length of a control sample; for example, deletions and insertions can be detected by a change in size of the amplified product compared to a normal genotype.
• SNP genotyping is useful for numerous practical applications, as described below. Examples of such applications include, but are not limited to, SNP-disease association analysis, disease predisposition screening, disease diagnosis, disease prognosis, disease progression monitoring, determining therapeutic strategies based on an individual's genotype (“pharmacogenomics”), developing therapeutic agents based on SNP genotypes associated with a disease or likelihood of responding to a drug, stratifying patient populations for clinical trials of a therapeutic, preventive, or diagnostic agent, and predicting the likelihood that an individual will experience toxic side effects from a therapeutic agent.
• Analysis of Genetic Associations Between SNPs and Phenotypic Traits
• SNP genotyping for disease diagnosis, disease predisposition screening, disease prognosis, determining drug responsiveness (pharmacogenomics), drug toxicity screening, and other uses described herein, typically relies on initially establishing a genetic association between one or more specific SNPs and the particular phenotypic traits of interest.
• Different study designs may be used for genetic association studies. Modern Epidemiology 609-622, Lippincott, Williams & Wilkins (1998). Observational studies are most frequently carried out in which the response of the patients is not interfered with. The first type of observational study identifies a sample of persons in whom the suspected cause of the disease is present and another sample of persons in whom the suspected cause is absent, and then the frequency of development of disease in the two samples is compared. These sampled populations are called cohorts, and the study is a prospective study. The other type of observational study is case-control or a retrospective study. In typical case-control studies, samples are collected from individuals with the phenotype of interest (cases) such as certain manifestations of a disease, and from individuals without the phenotype (controls) in a population (target population) that conclusions are to be drawn from. Then the possible causes of the disease are investigated retrospectively. As the time and costs of collecting samples in case-control studies are considerably less than those for prospective studies, case-control studies are the more commonly used study design in genetic association studies, at least during the exploration and discovery stage.
• Case-only studies are an alternative to case-control studies when gene-environment interaction is the association of interest (Piegorsch et al., “Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies”, Statistics in Medicine 13 (1994) pp 153-162). In a typical case-only study of gene-environment interaction, genotypes are obtained only from cases who are often selected from an existing cohort study. The association between genotypes and the environmental factor is then assessed and a significant association implies that the effect of the environmental factor on the endpoint of interest (the case definition) differs by genotype. The primary assumption underlying the test of association in case-only studies is that the environmental effect of interest is independent of genotype (e.g., allocation to statin therapy is independent of genotype) and it has been shown that the case-only design has more power than the case-control design to detect gene-environment interaction when this assumption is true in the population (Yang et al., “Sample Size Requirements in Case-Only Designs to Detect Gene-Environment Interaction”, American Journal of Epidemiology 146:9 (1997) pp 713-720). Selecting cases from a randomized clinical trial may be an ideal setting in which to perform a case-only study since genotypes will be independent of treatment by design.
• In observational studies, there may be potential confounding factors that should be taken into consideration. Confounding factors are those that are associated with both the real cause(s) of the disease and the disease itself, and they include demographic information such as age, gender, ethnicity as well as environmental factors. When confounding factors are not matched in cases and controls in a study, and are not controlled properly, spurious association results can arise. If potential confounding factors are identified, they should be controlled for by analysis methods explained below.
• In a genetic association study, the cause of interest to be tested is a certain allele or a SNP or a combination of alleles or a haplotype from several SNPs. Thus, tissue specimens (e.g., whole blood) from the sampled individuals may be collected and genomic DNA genotyped for the SNP(s) of interest. In addition to the phenotypic trait of interest, other information such as demographic (e.g., age, gender, ethnicity, etc.), clinical, and environmental information that may influence the outcome of the trait can be collected to further characterize and define the sample set. In many cases, these factors are known to be associated with diseases and/or SNP allele frequencies. There are likely gene-environment and/or gene-gene interactions as well. Analysis methods to address gene-environment and gene-gene interactions (for example, the effects of the presence of both susceptibility alleles at two different genes can be greater than the effects of the individual alleles at two genes combined) are discussed below.
• After all the relevant phenotypic and genotypic information has been obtained, statistical analyses are carried out to determine if there is any significant correlation between the presence of an allele or a genotype with the phenotypic characteristics of an individual. Preferably, data inspection and cleaning are first performed before carrying out statistical tests for genetic association. Epidemiological and clinical data of the samples can be summarized by descriptive statistics with tables and graphs. Data validation is preferably performed to check for data completion, inconsistent entries, and outliers. Chi-squared tests and t-tests (Wilcoxon rank-sum tests if distributions are not normal) may then be used to check for significant differences between cases and controls for discrete and continuous variables, respectively. To ensure genotyping quality, Hardy-Weinberg disequilibrium tests can be performed on cases and controls separately. Significant deviation from Hardy-Weinberg equilibrium (HWE) in both cases and controls for individual markers can be indicative of genotyping errors. If HWE is violated in a majority of markers, it is indicative of population substructure that should be further investigated. Moreover, Hardy-Weinberg disequilibrium in cases only can indicate genetic association of the markers with the disease. B. Weir, Genetic Data Analysis, Sinauer (1990).
• To test whether an allele of a single SNP is associated with the case or control status of a phenotypic trait, one skilled in the art can compare allele frequencies in cases and controls. Standard chi-squared tests and Fisher exact tests can be carried out on a 2×2 table (2 SNP alleles×2 outcomes in the categorical trait of interest). To test whether genotypes of a SNP are associated, chi-squared tests can be carried out on a 3×2 table (3 genotypes×2 outcomes). Score tests are also carried out for genotypic association to contrast the three genotypic frequencies (major homozygotes, heterozygotes and minor homozygotes) in cases and controls, and to look for trends using 3 different modes of inheritance, namely dominant (with contrast coefficients 2, −1, −1), additive or allelic (with contrast coefficients 1, 0, −1) and recessive (with contrast coefficients 1, 1, −2). Odds ratios for minor versus major alleles, and odds ratios for heterozygote and homozygote variants versus the wild type genotypes are calculated with the desired confidence limits, usually 95%.
• In order to control for confounders and to test for interaction and effect modifiers, stratified analyses may be performed using stratified factors that are likely to be confounding, including demographic information such as age, ethnicity, and gender, or an interacting element or effect modifier, such as a known major gene (e.g., APOE for Alzheimer's disease or HLA genes for autoimmune diseases), or environmental factors such as smoking in lung cancer. Stratified association tests may be carried out using Cochran-Mantel-Haenszel tests that take into account the ordinal nature of genotypes with 0, 1, and 2 variant alleles. Exact tests by StatXact may also be performed when computationally possible. Another way to adjust for confounding effects and test for interactions is to perform stepwise multiple logistic regression analysis using statistical packages such as SAS or R. Logistic regression is a model-building technique in which the best fitting and most parsimonious model is built to describe the relation between the dichotomous outcome (for instance, getting a certain disease or not) and a set of independent variables (for instance, genotypes of different associated genes, and the associated demographic and environmental factors). The most common model is one in which the logit transformation of the odds ratios is expressed as a linear combination of the variables (main effects) and their cross-product terms (interactions). Hosmer and Lemeshow, Applied Logistic Regression, Wiley (2000). To test whether a certain variable or interaction is significantly associated with the outcome, coefficients in the model are first estimated and then tested for statistical significance of their departure from zero.
• In addition to performing association tests one marker at a time, haplotype association analysis may also be performed to study a number of markers that are closely linked together. Haplotype association tests can have better power than genotypic or allelic association tests when the tested markers are not the disease-causing mutations themselves but are in linkage disequilibrium with such mutations. The test will even be more powerful if the disease is indeed caused by a combination of alleles on a haplotype (e.g., APOE is a haplotype formed by 2 SNPs that are very close to each other). In order to perform haplotype association effectively, marker-marker linkage disequilibrium measures, both D′ and r², are typically calculated for the markers within a gene to elucidate the haplotype structure. Recent studies in linkage disequilibrium indicate that SNPs within a gene are organized in block pattern, and a high degree of linkage disequilibrium exists within blocks and very little linkage disequilibrium exists between blocks. Daly et al, Nature Genetics 29:232-235 (2001). Haplotype association with the disease status can be performed using such blocks once they have been elucidated.
• Haplotype association tests can be carried out in a similar fashion as the allelic and genotypic association tests. Each haplotype in a gene is analogous to an allele in a multi-allelic marker. One skilled in the art can either compare the haplotype frequencies in cases and controls or test genetic association with different pairs of haplotypes. It has been proposed that score tests can be done on haplotypes using the program “haplo.score.” Schaid et al, Am J Hum Genet 70:425-434 (2002). In that method, haplotypes are first inferred by EM algorithm and score tests are carried out with a generalized linear model (GLM) framework that allows the adjustment of other factors.
• An important decision in the performance of genetic association tests is the determination of the significance level at which significant association can be declared when the P value of the tests reaches that level. In an exploratory analysis where positive hits will be followed up in subsequent confirmatory testing, an unadjusted P value <0.2 (a significance level on the lenient side), for example, may be used for generating hypotheses for significant association of a SNP with certain phenotypic characteristics of a disease. It is preferred that a p-value <0.05 (a significance level traditionally used in the art) is achieved in order for a SNP to be considered to have an association with a disease. It is more preferred that a p-value <0.01 (a significance level on the stringent side) is achieved for an association to be declared. When hits are followed up in confirmatory analyses in more samples of the same source or in different samples from different sources, adjustment for multiple testing will be performed as to avoid excess number of hits while maintaining the experiment-wide error rates at 0.05. While there are different methods to adjust for multiple testing to control for different kinds of error rates, a commonly used but rather conservative method is Bonferroni correction to control the experiment-wise or family-wise error rate. Westfall et al., Multiple comparisons and multiple tests, SAS Institute (1999). Permutation tests to control for the false discovery rates, FDR, can be more powerful. Benjamini and Hochberg, Journal of the Royal Statistical Society, Series B 57:1289-1300 (1995); Westfall and Young, Resampling-based Multiple Testing, Wiley (1993). Such methods to control for multiplicity would be preferred when the tests are dependent and controlling for false discovery rates is sufficient as opposed to controlling for the experiment-wise error rates.
• In replication studies using samples from different populations after statistically significant markers have been identified in the exploratory stage, meta-analyses can then be performed by combining evidence of different studies. Modern Epidemiology 643-673, Lippincott, Williams & Wilkins (1998). If available, association results known in the art for the same SNPs can be included in the meta-analyses.
• Since both genotyping and disease status classification can involve errors, sensitivity analyses may be performed to see how odds ratios and p-values would change upon various estimates on genotyping and disease classification error rates.
• It has been well known that subpopulation-based sampling bias between cases and controls can lead to spurious results in case-control association studies when prevalence of the disease is associated with different subpopulation groups. Ewens and Spielman, Am J Hum Genet 62:450-458 (1995). Such bias can also lead to a loss of statistical power in genetic association studies. To detect population stratification, Pritchard and Rosenberg suggested typing markers that are unlinked to the disease and using results of association tests on those markers to determine whether there is any population stratification. Pritchard et al., Am J Hum Gen 65:220-228 (1999). When stratification is detected, the genomic control (GC) method as proposed by Devlin and Roeder can be used to adjust for the inflation of test statistics due to population stratification. Devlin et al., Biometrics 55:997-1004 (1999). The GC method is robust to changes in population structure levels as well as being applicable to DNA pooling designs. Devlin et al., Genet Epidem 21:273-284 (2001).
• While Pritchard's method recommended using 15-20 unlinked microsatellite markers, it suggested using more than 30 biallelic markers to get enough power to detect population stratification. For the GC method, it has been shown that about 60-70 biallelic markers are sufficient to estimate the inflation factor for the test statistics due to population stratification. Bacanu et al., Am J Hum Genet 66:1933-1944 (2000). Hence, 70 intergenic SNPs can be chosen in unlinked regions as indicated in a genome scan. Kehoe et al., Hum Mol Genet 8:237-245 (1999).
• Once individual risk factors, genetic or non-genetic, have been found for the predisposition to disease, the next step is to set up a classification/prediction scheme to predict the category (for instance, disease or no-disease) that an individual will be in depending on his genotypes of associated SNPs and other non-genetic risk factors. Logistic regression for discrete trait and linear regression for continuous trait are standard techniques for such tasks. Draper and Smith, Applied Regression Analysis, Wiley (1998). Moreover, other techniques can also be used for setting up classification. Such techniques include, but are not limited to, MART, CART, neural network, and discriminant analyses that are suitable for use in comparing the performance of different methods. The Elements of Statistical Learning, Hastie, Tibshirani & Friedman, Springer (2002).
• For further information about genetic association studies, see Balding, “A tutorial on statistical methods for population association studies”, Nature Reviews Genetics 7, 781 (2006).
• Disease Diagnosis and Predisposition Screening
• Information on association/correlation between genotypes and disease-related phenotypes can be exploited in several ways. For example, in the case of a highly statistically significant association between one or more SNPs with predisposition to a disease for which treatment is available, detection of such a genotype pattern in an individual may justify immediate administration of treatment, or at least the institution of regular monitoring of the individual. Detection of the susceptibility alleles associated with serious disease in a couple contemplating having children may also be valuable to the couple in their reproductive decisions. In the case of a weaker but still statistically significant association between a SNP and a human disease, immediate therapeutic intervention or monitoring may not be justified after detecting the susceptibility allele or SNP. Nevertheless, the subject can be motivated to begin simple life-style changes (e.g., diet, exercise) that can be accomplished at little or no cost to the individual but would confer potential benefits in reducing the risk of developing conditions for which that individual may have an increased risk by virtue of having the risk allele(s).
• The SNPs of the invention may contribute to responsiveness of an individual to statin treatment, or to the development of CVD (e.g., CHD, such as MI), in different ways. Some polymorphisms occur within a protein coding sequence and contribute to disease phenotype by affecting protein structure. Other polymorphisms occur in noncoding regions but may exert phenotypic effects indirectly via influence on, for example, replication, transcription, and/or translation. A single SNP may affect more than one phenotypic trait. Likewise, a single phenotypic trait may be affected by multiple SNPs in different genes.
• As used herein, the terms “diagnose,” “diagnosis,” and “diagnostics” include, but are not limited to, any of the following: detection of CVD (e.g., CHD, such as MI) that an individual may presently have, predisposition/susceptibility/predictive screening (i.e., determining whether an individual has an increased or decreased risk of developing CVD in the future), predicting recurrence of CVD (e.g., recurrent MI) in an individual, determining a particular type or subclass of CVD in an individual who currently or previously had CVD, confirming or reinforcing a previously made diagnosis of CVD, evaluating an individual's likelihood of responding positively to a particular treatment or therapeutic agent (i.e., benefiting) such as statin treatment (particularly treatment or prevention of CVD, especially CHD such as MI, using statins), determining or selecting a therapeutic or preventive strategy that an individual is most likely to positively respond to (e.g., selecting a particular therapeutic agent such as a statin, or combination of therapeutic agents, or selecting a particular statin from among other statins, or determining a dosing regimen or selecting a dosage formulation, etc.), classifying (or confirming/reinforcing) an individual as a responder/non-responder (or determining a particular subtype of responder/non-responder) with respect to the individual's response to a drug treatment such as statin treatment, and predicting whether a patient is likely to experience toxic effects from a particular treatment or therapeutic compound. Such diagnostic uses can be based on the SNPs individually or a unique combination or SNPs disclosed herein, as well as SNP haplotypes.
• Haplotypes are particularly useful in that, for example, fewer SNPs can be genotyped to determine if a particular genomic region harbors a locus that influences a particular phenotype, such as in linkage disequilibrium-based SNP association analysis.
• Linkage disequilibrium (LD) refers to the co-inheritance of alleles (e.g., alternative nucleotides) at two or more different SNP sites at frequencies greater than would be expected from the separate frequencies of occurrence of each allele in a given population. The expected frequency of co-occurrence of two alleles that are inherited independently is the frequency of the first allele multiplied by the frequency of the second allele. Alleles that co-occur at expected frequencies are said to be in “linkage equilibrium.” In contrast, LD refers to any non-random genetic association between allele(s) at two or more different SNP sites, which is generally due to the physical proximity of the two loci along a chromosome. LD can occur when two or more SNPs sites are in close physical proximity to each other on a given chromosome and therefore alleles at these SNP sites will tend to remain unseparated for multiple generations with the consequence that a particular nucleotide (allele) at one SNP site will show a non-random association with a particular nucleotide (allele) at a different SNP site located nearby. Hence, genotyping one of the SNP sites will give almost the same information as genotyping the other SNP site that is in LD.
• Various degrees of LD can be encountered between two or more SNPs with the result being that some SNPs are more closely associated (i.e., in stronger LD) than others. Furthermore, the physical distance over which LD extends along a chromosome differs between different regions of the genome, and therefore the degree of physical separation between two or more SNP sites necessary for LD to occur can differ between different regions of the genome.
• For diagnostic purposes and similar uses, if a particular SNP site is found to be useful for, for example, predicting an individual's response to statin treatment or an individual's susceptibility to CVD, then the skilled artisan would recognize that other SNP sites which are in LD with this SNP site would also be useful for the same purposes. Thus, polymorphisms (e.g., SNPs and/or haplotypes) that are not the actual disease-causing (causative) polymorphisms, but are in LD with such causative polymorphisms, are also useful. In such instances, the genotype of the polymorphism(s) that is/are in LD with the causative polymorphism is predictive of the genotype of the causative polymorphism and, consequently, predictive of the phenotype (e.g., response to statin treatment or risk for developing CVD) that is influenced by the causative SNP(s). Therefore, polymorphic markers that are in LD with causative polymorphisms are useful as diagnostic markers, and are particularly useful when the actual causative polymorphism(s) is/are unknown.
• Examples of polymorphisms that can be in LD with one or more causative polymorphisms (and/or in LD with one or more polymorphisms that have a significant statistical association with a condition) and therefore useful for diagnosing the same condition that the causative/associated SNP(s) is used to diagnose, include other SNPs in the same gene, protein-coding, or mRNA transcript-coding region as the causative/associated SNP, other SNPs in the same exon or same intron as the causative/associated SNP, other SNPs in the same haplotype block as the causative/associated SNP, other SNPs in the same intergenic region as the causative/associated SNP, SNPs that are outside but near a gene (e.g., within 6 kb on either side, 5′ or 3′, of a gene boundary) that harbors a causative/associated SNP, etc. Such useful LD SNPs can be selected from among the SNPs disclosed in Table 3, for example.
• Linkage disequilibrium in the human genome is reviewed in Wall et al., “Haplotype blocks and linkage disequilibrium in the human genome,” Nat Rev Genet 4(8):587-97 (August 2003); Garner et al., “On selecting markers for association studies: patterns of linkage disequilibrium between two and three diallelic loci,” Genet Epidemiol 24(1):57-67 (January 2003); Ardlie et al., “Patterns of linkage disequilibrium in the human genome,” Nat Rev Genet 3(4):299-309 (April 2002); erratum in Nat Rev Genet 3(7):566 (July 2002); and Remm et al., “High-density genotyping and linkage disequilibrium in the human genome using chromosome 22 as a model,” Curr Opin Chem Biol 6(1):24-30 (February 2002); J. B. S. Haldane, “The combination of linkage values, and the calculation of distances between the loci of linked factors,” J Genet 8:299-309 (1919); G. Mendel, Versuche über Pflanzen-Hybriden. Verhandlungen des naturforschenden Vereines in Brünn (Proceedings of the Natural History Society of Brünn) (1866); Genes IV, B. Lewin, ed., Oxford University Press, N.Y. (1990); D. L. Hartl and A. G. Clark Principles of Population Genetics 2^nd ed., Sinauer Associates, Inc., Mass. (1989); J. H. Gillespie Population Genetics: A Concise Guide. 2^nd ed., Johns Hopkins University Press (2004); R. C. Lewontin, “The interaction of selection and linkage. I. General considerations; heterotic models,” Genetics 49:49-67 (1964); P. G. Hoel, Introduction to Mathematical Statistics 2^nd ed., John Wiley & Sons, Inc., N.Y. (1954); R. R. Hudson, “Two-locus sampling distributions and their application,” Genetics 159:1805-1817 (2001); A. P. Dempster, N. M. Laird, D. B. Rubin, “Maximum likelihood from incomplete data via the EM algorithm,” J R Stat Soc 39:1-38 (1977); L. Excoffier, M. Slatkin, “Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population,” Mol Biol Evol 12(5):921-927 (1995); D. A. Tregouet, S. Escolano, L. Tiret, A. Mallet, J. L. Golmard, “A new algorithm for haplotype-based association analysis: the Stochastic-EM algorithm,” Ann Hum Genet 68(Pt 2):165-177 (2004); A. D. Long and C. H. Langley C H, “The power of association studies to detect the contribution of candidate genetic loci to variation in complex traits,” Genome Research 9:720-731 (1999); A. Agresti, Categorical Data Analysis, John Wiley & Sons, Inc., N.Y. (1990); K. Lange, Mathematical and Statistical Methods for Genetic Analysis, Springer-Verlag New York, Inc., N.Y. (1997); The International HapMap Consortium, “The International HapMap Project,” Nature 426:789-796 (2003); The International HapMap Consortium, “A haplotype map of the human genome,” Nature 437:1299-1320 (2005); G. A. Thorisson, A. V. Smith, L. Krishnan, L. D. Stein, “The International HapMap Project Web Site,” Genome Research 15:1591-1593 (2005); G. McVean, C. C. A. Spencer, R. Chaix, “Perspectives on human genetic variation from the HapMap project,” PLoS Genetics 1(4):413-418 (2005); J. N. Hirschhorn, M. J. Daly, “Genome-wide association studies for common diseases and complex traits,” Nat Genet 6:95-108 (2005); S. J. Schrodi, “A probabilistic approach to large-scale association scans: a semi-Bayesian method to detect disease-predisposing alleles,” SAGMB 4(1):31 (2005); W. Y. S. Wang, B. J. Barratt, D. G. Clayton, J. A. Todd, “Genome-wide association studies: theoretical and practical concerns,” Nat Rev Genet 6:109-118 (2005); J. K. Pritchard, M. Przeworski, “Linkage disequilibrium in humans: models and data,” Am J Hum Genet 69:1-14 (2001).
• As discussed above, an aspect of the present invention relates to SNPs that are in LD with an interrogated SNP and which can also be used as valid markers for determining an individual's likelihood of benefiting from statin treatment, or whether an individual has an increased or decreased risk of having or developing CVD. As used herein, the term “interrogated SNP” refers to SNPs that have been found to be associated with statin response, particularly for reducing CVD risk, using genotyping results and analysis, or other appropriate experimental method as exemplified in the working examples described in this application. As used herein, the term “LD SNP” refers to a SNP that has been characterized as a SNP associated with statin response or an increased or decreased risk of CVD due to their being in LD with the “interrogated SNP” under the methods of calculation described in the application. Below, applicants describe the methods of calculation with which one of ordinary skilled in the art may determine if a particular SNP is in LD with an interrogated SNP. The parameter r² is commonly used in the genetics art to characterize the extent of linkage disequilibrium between markers (Hudson, 2001). As used herein, the term “in LD with” refers to a particular SNP that is measured at above the threshold of a parameter such as r² with an interrogated SNP.
• It is now common place to directly observe genetic variants in a sample of chromosomes obtained from a population. Suppose one has genotype data at two genetic markers located on the same chromosome, for the markers A and B. Further suppose that two alleles segregate at each of these two markers such that alleles A₁ and A₂ can be found at marker A and alleles B₁ and B₂ at marker B. Also assume that these two markers are on a human autosome. If one is to examine a specific individual and find that they are heterozygous at both markers, such that their two-marker genotype is A₁A₂B₁B₂, then there are two possible configurations: the individual in question could have the alleles A₁B₁ on one chromosome and A₂B₂ on the remaining chromosome; alternatively, the individual could have alleles A₁B₂ on one chromosome and A₂B₁ on the other. The arrangement of alleles on a chromosome is called a haplotype. In this illustration, the individual could have haplotypes A₁B₁/A₂B₂ or A₁B₂/A₂B₁ (see Hartl and Clark (1989) for a more complete description). The concept of linkage equilibrium relates the frequency of haplotypes to the allele frequencies.
• Assume that a sample of individuals is selected from a larger population. Considering the two markers described above, each having two alleles, there are four possible haplotypes: A₁B₁, A₁B₂, A₂B₁ and A₂B₂. Denote the frequencies of these four haplotypes with the following notation.
• 
  P ₁₁=freq(A ₁ B ₁)  (1)
• 
  P ₁₂=freq(A ₁ B ₂)  (2)
• 
  P ₂₁=freq(A ₂ B ₁)  (3)
• 
  P ₂₂=freq(A ₂ B ₂)  (4)
• The allele frequencies at the two markers are then the sum of different haplotype frequencies, it is straightforward to write down a similar set of equations relating single-marker allele frequencies to two-marker haplotype frequencies:
• 
  p ₁=freq(A ₁)=P ₁₁ +P ₁₂  (5)
• 
  p ₂=freq(A ₂)=P ₂₁ +P ₂₂  (6)
• 
  q ₁=freq(B ₁)=P ₁₁ +P ₂₁  (7)
• 
  q ₂=freq(B ₂)=P ₁₂ +P ₂₂  (8)
• Note that the four haplotype frequencies and the allele frequencies at each marker must sum to a frequency of 1.
• 
  P ₁₁ +P ₁₂ +P ₂₁ +P ₂₂=1  (9)
• 
  p ₁ +p ₂=1  (10)
• 
  q ₁ +q ₂=1  (11)
• If there is no correlation between the alleles at the two markers, one would expect that the frequency of the haplotypes would be approximately the product of the composite alleles. Therefore,
• 
  P ₁₁ ≈p ₁ q ₁  (12)
• 
  P ₁₂ ≈p ₁ q ₂  (13)
• 
  P ₂₁ ≈p ₂ q ₁  (14)
• 
  P ₂₂ ≈p ₂ q ₂  (15)
• These approximating equations (12)-(15) represent the concept of linkage equilibrium where there is independent assortment between the two markers—the alleles at the two markers occur together at random. These are represented as approximations because linkage equilibrium and linkage disequilibrium are concepts typically thought of as properties of a sample of chromosomes; and as such they are susceptible to stochastic fluctuations due to the sampling process. Empirically, many pairs of genetic markers will be in linkage equilibrium, but certainly not all pairs.
• Having established the concept of linkage equilibrium above, applicants can now describe the concept of linkage disequilibrium (LD), which is the deviation from linkage equilibrium. Since the frequency of the A₁B₁ haplotype is approximately the product of the allele frequencies for A₁ and B₁ under the assumption of linkage equilibrium as stated mathematically in (12), a simple measure for the amount of departure from linkage equilibrium is the difference in these two quantities, D,
• 
  D=P ₁₁ −p ₁ q ₁  (16)
• D=0 indicates perfect linkage equilibrium. Substantial departures from D=0 indicates LD in the sample of chromosomes examined. Many properties of D are discussed in Lewontin (1964) including the maximum and minimum values that D can take. Mathematically, using basic algebra, it can be shown that D can also be written solely in terms of haplotypes:
• 
  D=P ₁₁ P ₂₂ −P ₁₂ P ₂₁  (17)
• If one transforms D by squaring it and subsequently dividing by the product of the allele frequencies of A₁, A₂, B₁ and B₂, the resulting quantity, called r², is equivalent to the square of the Pearson's correlation coefficient commonly used in statistics (e.g., Hoel, 1954).
• $\begin{array}{cc}{r}^2=\frac{D^2}{p_1p_2q_1q_2}& \left(18\right)\end{array}$
• As with D, values of r² close to 0 indicate linkage equilibrium between the two markers examined in the sample set. As values of r² increase, the two markers are said to be in linkage disequilibrium. The range of values that r² can take are from 0 to 1. r²=1 when there is a perfect correlation between the alleles at the two markers.
• In addition, the quantities discussed above are sample-specific. And as such, it is necessary to formulate notation specific to the samples studied. In the approach discussed here, three types of samples are of primary interest: (i) a sample of chromosomes from individuals affected by a disease-related phenotype (cases), (ii) a sample of chromosomes obtained from individuals not affected by the disease-related phenotype (controls), and (iii) a standard sample set used for the construction of haplotypes and calculation pairwise linkage disequilibrium. For the allele frequencies used in the development of the method described below, an additional subscript will be added to denote either the case or control sample sets.
• 
  p _1,cs=freq(A ₁ in cases)  (19)
• 
  p _2,cs=freq(A ₂ in cases)  (20)
• 
  q _1,cs=freq(B ₁ in cases)  (21)
• 
  q _2,cs=freq(B ₂ in cases)  (22)
• 
  Similarly,
• 
  p _1,ct=freq(A ₁ in controls)  (23)
• 
  p _2,ct=freq(A ₂ in controls)  (24)
• 
  q _1,ct=freq(B ₁ in controls)  (25)
• 
  q _2,ct=freq(B ₂ in controls)  (26)
• As a well-accepted sample set is necessary for robust linkage disequilibrium calculations, data obtained from the International HapMap project (The International HapMap Consortium 2003, 2005; Thorisson et al, 2005; McVean et al, 2005) can be used for the calculation of pairwise r² values. Indeed, the samples genotyped for the International HapMap Project were selected to be representative examples from various human sub-populations with sufficient numbers of chromosomes examined to draw meaningful and robust conclusions from the patterns of genetic variation observed. The International HapMap project website (hapmap.org) contains a description of the project, methods utilized and samples examined. It is useful to examine empirical data to get a sense of the patterns present in such data.
• Haplotype frequencies were explicit arguments in equation (18) above. However, knowing the 2-marker haplotype frequencies requires that phase to be determined for doubly heterozygous samples. When phase is unknown in the data examined, various algorithms can be used to infer phase from the genotype data. This issue was discussed earlier where the doubly heterozygous individual with a 2-SNP genotype of A₁A₂B₁B₂ could have one of two different sets of chromosomes: A₁B₁/A₂B₂ or A₁B₂/A₂B₁. One such algorithm to estimate haplotype frequencies is the expectation-maximization (EM) algorithm first formalized by Dempster et al. (1977). This algorithm is often used in genetics to infer haplotype frequencies from genotype data (e.g. Excoffier and Slatkin (1995); Tregouet et al. (2004)). It should be noted that for the two-SNP case explored here, EM algorithms have very little error provided that the allele frequencies and sample sizes are not too small. The impact on r² values is typically negligible.
• As correlated genetic markers share information, interrogation of SNP markers in LD with a disease-associated SNP marker can also have sufficient power to detect disease association (Long and Langley (1999)). The relationship between the power to directly find disease-associated alleles and the power to indirectly detect disease-association was investigated by Pritchard and Przeworski (2001). In a straight-forward derivation, it can be shown that the power to detect disease association indirectly at a marker locus in linkage disequilibrium with a disease-association locus is approximately the same as the power to detect disease-association directly at the disease-association locus if the sample size is increased by a factor of
• $\frac{1}{r^2}$
• (the reciprocal of equation 18) at the marker in comparison with the disease-association locus.
• Therefore, if one calculated the power to detect disease-association indirectly with an experiment having N samples, then equivalent power to directly detect disease-association (at the actual disease-susceptibility locus) would necessitate an experiment using approximately r²N samples. This elementary relationship between power, sample size and linkage disequilibrium can be used to derive an r² threshold value useful in determining whether or not genotyping markers in linkage disequilibrium with a SNP marker directly associated with disease status has enough power to indirectly detect disease-association.
• To commence a derivation of the power to detect disease-associated markers through an indirect process, define the effective chromosomal sample size as
• $\begin{array}{cc}n=\frac{4N_{\mathrm{cs}}N_{\mathrm{ct}}}{N_{\mathrm{cs}}+N_{\mathrm{ct}}};& \left(27\right)\end{array}$
• where N_cs and N_ct are the numbers of diploid cases and controls, respectively. This is necessary to handle situations where the numbers of cases and controls are not equivalent. For equal case and control sample sizes, N_cs=N_ct=N, the value of the effective number of chromosomes is simply n=2N—as expected. Let power be calculated for a significance level α (such that traditional P-values below α will be deemed statistically significant). Define the standard Gaussian distribution function as Φ(•). Mathematically,
• $\begin{array}{cc}\Phi \left(x\right)=\frac{1}{\sqrt{2\pi }}{\int }_{-\infty }^x{}^{-\frac{{\theta }^2}{2}}\theta & \left(28\right)\end{array}$
• Alternatively, the following error function notation (Erf) may also be used,
• $\begin{array}{cc}\Phi \left(x\right)=\frac{1}{2}\left[1+\mathrm{Erf}\left(\frac{x}{\sqrt{2}}\right)\right]& \left(29\right)\end{array}$
• For example, Φ(1.644854)=0.95. The value of r² may be derived to yield a pre-specified minimum amount of power to detect disease association though indirect interrogation. Noting that the LD SNP marker could be the one that is carrying the disease-association allele, therefore that this approach constitutes a lower-bound model where all indirect power results are expected to be at least as large as those interrogated.
• Denote by β the error rate for not detecting truly disease-associated markers. Therefore, 1−β is the classical definition of statistical power. Substituting the Pritchard-Pzreworski result into the sample size, the power to detect disease association at a significance level of α is given by the approximation
• $\begin{array}{cc}1-\beta \cong \Phi \left[\frac{q_{1,\mathrm{cs}}-q_{1,\mathrm{ct}}}{\sqrt{\frac{q_{1,\mathrm{cs}}\left(1-q_{1,\mathrm{cs}}\right)+q_{1,\mathrm{ct}}\left(1-q_{1,\mathrm{ct}}\right)}{r^2n}}}-Z_{1-\frac{\alpha }{2}}\right];& \left(30\right)\end{array}$
• where Z_u is the inverse of the standard normal cumulative distribution evaluated at u (uε(0,1)). Z_u=Φ⁻¹(u), where Φ(Φ⁻¹(u))=Φ⁻¹(Φ(u))=u. For example, setting α=0.05, and therefore 1−α/2=0.975, one obtains Z_0.975=1.95996. Next, setting power equal to a threshold of a minimum power of T,
• $\begin{array}{cc}T=\Phi \left[\frac{q_{1,\mathrm{cs}}-q_{1,\mathrm{ct}}}{\sqrt{\frac{q_{1,\mathrm{cs}}\left(1-q_{1,\mathrm{cs}}\right)+q_{1,\mathrm{ct}}\left(1-q_{1,\mathrm{ct}}\right)}{r^2n}}}-Z_{1-\frac{\alpha }{2}}\right]& \left(31\right)\end{array}$
• and solving for r², the following threshold r² is obtained:
• $\begin{array}{cc}{r}_T^2={\frac{\left[q_{1,\mathrm{cs}}\left(1-q_{1,\mathrm{cs}}\right)+q_{1,\mathrm{ct}}\left(1-q_{1,\mathrm{ct}}\right)\right]}{{n\left(q_{1,\mathrm{cs}}-q_{1,\mathrm{ct}}\right)}^2}\left[{\Phi }^{-1}\left(T\right)+Z_{1-\alpha /2}\right]}^2\mathrm{Or},& \left(32\right)\\ r_T^2=\frac{{\left(Z_T+Z_{1-\alpha /2}\right)}^2}{n}\left[\frac{q_{1,\mathrm{cs}}-{\left(q_{1,\mathrm{cs}}\right)}^2+q_{1,\mathrm{ct}}-{\left(q_{1,\mathrm{ct}}\right)}^2}{{\left(q_{1,\mathrm{cs}}-q_{1,\mathrm{ct}}\right)}^2}\right]& \left(33\right)\end{array}$
• Suppose that r² is calculated between an interrogated SNP and a number of other SNPs with varying levels of LD with the interrogated SNP. The threshold value r_T ² is the minimum value of linkage disequilibrium between the interrogated SNP and the potential LD SNPs such that the LD SNP still retains a power greater or equal to T for detecting disease-association. For example, suppose that SNP rs200 is genotyped in a case-control disease-association study and it is found to be associated with a disease phenotype. Further suppose that the minor allele frequency in 1,000 case chromosomes was found to be 16% in contrast with a minor allele frequency of 10% in 1,000 control chromosomes. Given those measurements one could have predicted, prior to the experiment, that the power to detect disease association at a significance level of 0.05 was quite high—approximately 98% using a test of allelic association. Applying equation (32) one can calculate a minimum value of r² to indirectly assess disease association assuming that the minor allele at SNP rs200 is truly disease-predisposing for a threshold level of power. If one sets the threshold level of power to be 80%, then r_T ²=0.489 given the same significance level and chromosome numbers as above. Hence, any SNP with a pairwise r² value with rs200 greater than 0.489 is expected to have greater than 80% power to detect the disease association. Further, this is assuming the conservative model where the LD SNP is disease-associated only through linkage disequilibrium with the interrogated SNP rs200.
• Imputation
• Genotypes of SNPs can be imputed without actually having to be directly genotyped (referred to as “imputation”), by using known haplotype information. Imputation is a process to provide “missing” data, either missing individual genotypes (alleles) or missing SNPs and concomitant genotypes, which have not been directly genotyped (i.e., assayed). Imputation is particularly useful for identifying disease associations for specific ungenotyped SNPs by inferring the missing genotypes to these ungenotyped SNPs. Although the process uses similar information to LD, since the phasing and imputation process uses information from multiple SNPs at the same time, the phased haplotype, it is able to infer the genotype and achieve high identifiable accuracy. Genotype information (such as from the HapMap project by The International HapMap Consortium, NCBI, NLM, NIH) can be used to infer haplotype phase and impute genotypes for SNPs that are not directly genotyped in a given individual or sample set (such as for a disease association study). In general, imputation uses a reference dataset in which the genotypes of potential SNPs that are to be tested for disease association have been determined in multiple individuals (such as in HapMap); the individuals in the reference dataset are then haplotype phased. This phasing can be done with independent programs such as fastPHASE (Sheet and Stephens, Am J Hum Genet (2006) 76: 629-644) or a combination program such as BEAGLE which does both the phasing and the imputation. The reference phased haplotypes and process can be checked using the children of the HapMap individual parents, among other mechanisms. Once the reference phased haplotypes have been created, the imputation of additional individuals for SNPs genotyped or complete sets of SNPs that have not been directly genotyped can then proceed. The HapMap dataset is particularly useful as the reference dataset, however other datasets can be used. Since the imputation creates new concommitant phased haplotypes for individuals in the association study and these contain other SNPs within the genomic region, these ungenotyped but imputed SNPs can also be tested for disease associations (or other traits). Certain exemplary methods for haplotype phase inference and imputation of missing genotypes utilize the BEAGLE genetic analysis program, (Browning, Hum Genet (2008) 124:439-450).
• Thus, SNPs for which genotypes are imputed can be tested for association with a disease or other trait even though these SNPs are not directly genotyped. The SNPs for which genotypes are imputed have genotype data available in the reference dataset, e.g. HapMap individuals, but they are not directly genotyped in a particular individual or sample set (such as in a particular disease association study).
• In addition to using a reference dataset (e.g., HapMap) to impute genotypes of SNPs that are not directly genotyped in a study, imputation can provide genotypes of SNPs that were directly genotyped in a study but for which the genotypes are missing in some or most of the individuals for some reason, such as because they failed to pass quality control. Imputation can also be used to combine genotyping results from multiple studies in which different sets of SNPs were genotyped to construct a complete meta-analysis. For example, genotyped and imputed genotyped SNP results from multiple different studies can be combined, and the overlapping SNP genotypes (e.g., genotyped in one study, imputed in another study or imputed in both or genotyped in both) can be analyzed across all of the studies (Browning, Hum Genet (2008) 124:439-450).
• For a review of imputation (as well as the BEAGLE program), see Browning, “Missing data imputation and haplotype phase inference for genome-wide association studies”, Hum Genet (2008) 124:439-450 and Browning et al. “A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals”, Am J Hum Genet. (2009) February; 84(2):210-23, each of which is incorporated herein by reference in its entirety.
• The contribution or association of particular SNPs with statin response or disease phenotypes, such as CVD, enables the SNPs of the present invention to be used to develop superior diagnostic tests capable of identifying individuals who express a detectable trait, such as reduced risk for CVD (particularly CHD, such as MI) in response to statin treatment, as the result of a specific genotype, or individuals whose genotype places them at an increased or decreased risk of developing a detectable trait at a subsequent time as compared to individuals who do not have that genotype. As described herein, diagnostics may be based on a single SNP or a group of SNPs. Combined detection of a plurality of SNPs (for example, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 24, 25, 30, 32, 48, 50, 64, 96, 100, or any other number in-between, or more, of the SNPs provided in Table 1 and/or Table 2) typically increases the probability of an accurate diagnosis. For example, the presence of a single SNP known to correlate with CVD might indicate a probability of 20% that an individual has or is at risk of developing CVD, whereas detection of five SNPs, each of which correlates with CVD, might indicate a probability of 80% that an individual has or is at risk of developing CVD. To further increase the accuracy of diagnosis or predisposition screening, analysis of the SNPs of the present invention can be combined with that of other polymorphisms or other risk factors of CVD, such as disease symptoms, pathological characteristics, family history, diet, environmental factors, or lifestyle factors.
• It will be understood by practitioners skilled in the treatment or diagnosis of CVD that the present invention generally does not intend to provide an absolute identification of individuals who benefit from statin treatment or individuals who are at risk (or less at risk) of developing CVD, but rather to indicate a certain increased (or decreased) degree or likelihood of responding to statin therapy or developing CVD based on statistically significant association results. However, this information is extremely valuable as it can be used to, for example, encourage individuals to comply with their statin regimens as prescribed by their doctors (even though the benefit of maintaining statin therapy may not be overtly apparent, which often leads to lack of compliance with prescribed statin treatment), to initiate preventive treatments or to allow an individual carrying one or more significant SNPs or SNP haplotypes to foresee warning signs such as minor clinical symptoms, or to have regularly scheduled physical exams to monitor for appearance of a condition in order to identify and begin treatment of the condition at an early stage. Particularly with diseases that are extremely debilitating or fatal if not treated on time, the knowledge of a potential predisposition, even if this predisposition is not absolute, would likely contribute in a very significant manner to treatment efficacy.
• The diagnostic techniques of the present invention may employ a variety of methodologies to determine whether a test subject has a SNP or combination of SNPs associated with an increased or decreased risk of developing a detectable trait or whether the individual suffers from a detectable trait as a result of a particular polymorphism/mutation, including, for example, methods which enable the analysis of individual chromosomes for haplotyping, family studies, single sperm DNA analysis, or somatic hybrids. The trait analyzed using the diagnostics of the invention may be any detectable trait that is commonly observed in pathologies and disorders related to CVD or drug response.
• Another aspect of the present invention relates to a method of determining whether an individual is at risk (or less at risk) of developing one or more traits or whether an individual expresses one or more traits as a consequence of possessing a particular trait-causing or trait-influencing allele. These methods generally involve obtaining a nucleic acid sample from an individual and assaying the nucleic acid sample to determine which nucleotide(s) is/are present at one or more SNP positions, wherein the assayed nucleotide(s) is/are indicative of an increased or decreased risk of developing the trait or indicative that the individual expresses the trait as a result of possessing a particular trait-causing or trait-influencing allele.
• In another embodiment, the SNP detection reagents of the present invention are used to determine whether an individual has one or more SNP allele(s) affecting the level (e.g., the concentration of mRNA or protein in a sample, etc.) or pattern (e.g., the kinetics of expression, rate of decomposition, stability profile, Km, Vmax, etc.) of gene expression (collectively, the “gene response” of a cell or bodily fluid). Such a determination can be accomplished by screening for mRNA or protein expression (e.g., by using nucleic acid arrays, RT-PCR, TaqMan assays, or mass spectrometry), identifying genes having altered expression in an individual, genotyping SNPs disclosed in Table 1 and/or Table 2 that could affect the expression of the genes having altered expression (e.g., SNPs that are in and/or around the gene(s) having altered expression, SNPs in regulatory/control regions, SNPs in and/or around other genes that are involved in pathways that could affect the expression of the gene(s) having altered expression, or all SNPs could be genotyped), and correlating SNP genotypes with altered gene expression. In this manner, specific SNP alleles at particular SNP sites can be identified that affect gene expression.
• Therapeutics, Pharmacogenomics, and Drug Development
• Therapeutic Methods and Compositions
• In certain aspects of the invention, there are provided methods of assaying (i.e., testing) one or more SNPs provided by the present invention in an individual's nucleic acids, and administering a therapeutic or preventive agent to the individual based on the allele(s) present at the SNP(s) having indicated that the individual can benefit from the therapeutic or preventive agent.
• In further aspects of the invention, there are provided methods of assaying one or more SNPs provided by the present invention in an individual's nucleic acids, and administering a diagnostic agent (e.g., an imaging agent), or otherwise carrying out further diagnostic procedures on the individual, based on the allele(s) present at the SNP(s) having indicated that the diagnostic agents or diagnostics procedures are justified in the individual.
• In yet other aspects of the invention, there is provided a pharmaceutical pack comprising a therapeutic agent (e.g., a small molecule drug, antibody, peptide, antisense or RNAi nucleic acid molecule, etc.) and a set of instructions for administration of the therapeutic agent to an individual who has been tested for one or more SNPs provided by the present invention.
• Pharmacogenomics
• The present invention provides methods for assessing the pharmacogenomics of a subject harboring particular SNP alleles or haplotypes to a particular therapeutic agent or pharmaceutical compound, or to a class of such compounds. Pharmacogenomics deals with the roles which clinically significant hereditary variations (e.g., SNPs) play in the response to drugs due to altered drug disposition and/or abnormal action in affected persons. See, e.g., Roses, Nature 405, 857-865 (2000); Gould Rothberg, Nature Biotechnology 19, 209-211 (2001); Eichelbaum, Clin Exp Pharmacol Physiol 23(10-11):983-985 (1996); and Linder, Clin Chem 43(2):254-266 (1997). The clinical outcomes of these variations can result in severe toxicity of therapeutic drugs in certain individuals or therapeutic failure of drugs in certain individuals as a result of individual variation in metabolism. Thus, the SNP genotype of an individual can determine the way a therapeutic compound acts on the body or the way the body metabolizes the compound. For example, SNPs in drug metabolizing enzymes can affect the activity of these enzymes, which in turn can affect both the intensity and duration of drug action, as well as drug metabolism and clearance.
• The discovery of SNPs in drug metabolizing enzymes, drug transporters, proteins for pharmaceutical agents, and other drug targets has explained why some patients do not obtain the expected drug effects, show an exaggerated drug effect, or experience serious toxicity from standard drug dosages. SNPs can be expressed in the phenotype of the extensive metabolizer and in the phenotype of the poor metabolizer. Accordingly, SNPs may lead to allelic variants of a protein in which one or more of the protein functions in one population are different from those in another population. SNPs and the encoded variant peptides thus provide targets to ascertain a genetic predisposition that can affect treatment modality. For example, in a ligand-based treatment, SNPs may give rise to amino terminal extracellular domains and/or other ligand-binding regions of a receptor that are more or less active in ligand binding, thereby affecting subsequent protein activation. Accordingly, ligand dosage would necessarily be modified to maximize the therapeutic effect within a given population containing particular SNP alleles or haplotypes.
• As an alternative to genotyping, specific variant proteins containing variant amino acid sequences encoded by alternative SNP alleles could be identified. Thus, pharmacogenomic characterization of an individual permits the selection of effective compounds and effective dosages of such compounds for prophylactic or therapeutic uses based on the individual's SNP genotype, thereby enhancing and optimizing the effectiveness of the therapy. Furthermore, the production of recombinant cells and transgenic animals containing particular SNPs/haplotypes allow effective clinical design and testing of treatment compounds and dosage regimens. For example, transgenic animals can be produced that differ only in specific SNP alleles in a gene that is orthologous to a human disease susceptibility gene.
• Pharmacogenomic uses of the SNPs of the present invention provide several significant advantages for patient care, particularly in predicting an individual's responsiveness to statin treatment (particularly for reducing the risk of CVD, especially CHD such as MI) and in predicting an individual's predisposition to CVD (e.g., CHD such as MI). Pharmacogenomic characterization of an individual, based on an individual's SNP genotype, can identify those individuals unlikely to respond to treatment with a particular medication and thereby allows physicians to avoid prescribing the ineffective medication to those individuals. On the other hand, SNP genotyping of an individual may enable physicians to select the appropriate medication and dosage regimen that will be most effective based on an individual's SNP genotype. This information increases a physician's confidence in prescribing medications and motivates patients to comply with their drug regimens. Furthermore, pharmacogenomics may identify patients predisposed to toxicity and adverse reactions to particular drugs or drug dosages. Adverse drug reactions lead to more than 100,000 avoidable deaths per year in the United States alone and therefore represent a significant cause of hospitalization and death, as well as a significant economic burden on the healthcare system (Pfost et al., Trends in Biotechnology, August 2000). Thus, pharmacogenomics based on the SNPs disclosed herein has the potential to both save lives and reduce healthcare costs substantially.
• Pharmacogenomics in general is discussed further in Rose et al., “Pharmacogenetic analysis of clinically relevant genetic polymorphisms,” Methods Mol Med 85:225-37 (2003). Pharmacogenomics as it relates to Alzheimer's disease and other neurodegenerative disorders is discussed in Cacabelos, “Pharmacogenomics for the treatment of dementia,” Ann Med 34(5):357-79 (2002); Maimone et al., “Pharmacogenomics of neurodegenerative diseases,” Eur J Pharmacol 413(1):11-29 (February 2001); and Poirier, “Apolipoprotein E: a pharmacogenetic target for the treatment of Alzheimer's disease,” Mol Diagn 4(4):335-41 (December 1999). Pharmacogenomics as it relates to cardiovascular disorders is discussed in Siest et al., “Pharmacogenomics of drugs affecting the cardiovascular system,” Clin Chem Lab Med 41(4):590-9 (April 2003); Mukherjee et al., “Pharmacogenomics in cardiovascular diseases,” Prog Cardiovasc Dis 44(6):479-98 (May-June 2002); and Mooser et al., “Cardiovascular pharmacogenetics in the SNP era,” J Thromb Haemost 1(7):1398-402 (July 2003). Pharmacogenomics as it relates to cancer is discussed in McLeod et al., “Cancer pharmacogenomics: SNPs, chips, and the individual patient,” Cancer Invest 21(4):630-40 (2003); and Watters et al., “Cancer pharmacogenomics: current and future applications,” Biochim Biophys Acta 1603(2):99-111 (March 2003).
• Clinical Trials
• In certain aspects of the invention, there are provided methods of using the SNPs disclosed herein to identify or stratify patient populations for clinical trials of a therapeutic, preventive, or diagnostic agent.
• For instance, an aspect of the present invention includes selecting individuals for clinical trials based on their SNP genotype, such as selecting individuals for inclusion in a clinical trial and/or assigning individuals to a particular group within a clinical trial (e.g., an “arm” of the trial). For example, individuals with SNP genotypes that indicate that they are likely to positively respond to a drug can be included in the trials, whereas those individuals whose SNP genotypes indicate that they are less likely to or would not respond to the drug, or who are at risk for suffering toxic effects or other adverse reactions, can be excluded from the clinical trials. This not only can improve the safety of clinical trials, but also can enhance the chances that the trial will demonstrate statistically significant efficacy. Further, one can stratify a prospective trial with patients with different SNP variants to determine the impact of differential drug treatment.
• Thus, certain embodiments of the invention provide methods for conducting a clinical trial of a therapeutic agent in which a human is selected for inclusion in the clinical trial and/or assigned to a particular group within a clinical trial based on the presence or absence of one or more SNPs disclosed herein. In certain embodiments, the therapeutic agent is a statin.
• In certain exemplary embodiments, SNPs of the invention can be used to select individuals who are unlikely to respond positively to a particular therapeutic agent (or class of therapeutic agents) based on their SNP genotype(s) to participate in a clinical trial of another type of drug that may benefit them. Thus, in certain embodiments, the SNPs of the invention can be used to identify patient populations who do not adequately respond to current treatments and are therefore in need of new therapies. This not only benefits the patients themselves, but also benefits organizations such as pharmaceutical companies by enabling the identification of populations that represent markets for new drugs, and enables the efficacy of these new drugs to be tested during clinical trials directly in individuals within these markets.
• The SNP-containing nucleic acid molecules of the present invention are also useful for monitoring the effectiveness of modulating compounds on the expression or activity of a variant gene, or encoded product, particularly in a treatment regimen or in clinical trials. Thus, the gene expression pattern can serve as an indicator for the continuing effectiveness of treatment with the compound, particularly with compounds to which a patient can develop resistance, as well as an indicator for toxicities. The gene expression pattern can also serve as a marker indicative of a physiological response of the affected cells to the compound. Accordingly, such monitoring would allow either increased administration of the compound or the administration of alternative compounds to which the patient has not become resistant.
• Furthermore, the SNPs of the present invention may have utility in determining why certain previously developed drugs performed poorly in clinical trials and may help identify a subset of the population that would benefit from a drug that had previously performed poorly in clinical trials, thereby “rescuing” previously developed drugs, and enabling the drug to be made available to a particular patient population (e.g., particular CVD patients) that can benefit from it.
• Identification, Screening, and Use of Therapeutic Agents
• The SNPs of the present invention also can be used to identify novel therapeutic targets for CVD, particularly CHD, such as MI, or stroke. For example, genes containing the disease-associated variants (“variant genes”) or their products, as well as genes or their products that are directly or indirectly regulated by or interacting with these variant genes or their products, can be targeted for the development of therapeutics that, for example, treat the disease or prevent or delay disease onset. The therapeutics may be composed of, for example, small molecules, proteins, protein fragments or peptides, antibodies, nucleic acids, or their derivatives or mimetics which modulate the functions or levels of the target genes or gene products.
• The invention further provides methods for identifying a compound or agent that can be used to treat CVD, particularly CHD such as MI. The SNPs disclosed herein are useful as targets for the identification and/or development of therapeutic agents. A method for identifying a therapeutic agent or compound typically includes assaying the ability of the agent or compound to modulate the activity and/or expression of a SNP-containing nucleic acid or the encoded product and thus identifying an agent or a compound that can be used to treat a disorder characterized by undesired activity or expression of the SNP-containing nucleic acid or the encoded product. The assays can be performed in cell-based and cell-free systems. Cell-based assays can include cells naturally expressing the nucleic acid molecules of interest or recombinant cells genetically engineered to express certain nucleic acid molecules.
• Variant gene expression in a CVD patient can include, for example, either expression of a SNP-containing nucleic acid sequence (for instance, a gene that contains a SNP can be transcribed into an mRNA transcript molecule containing the SNP, which can in turn be translated into a variant protein) or altered expression of a normal/wild-type nucleic acid sequence due to one or more SNPs (for instance, a regulatory/control region can contain a SNP that affects the level or pattern of expression of a normal transcript).
• Assays for variant gene expression can involve direct assays of nucleic acid levels (e.g., mRNA levels), expressed protein levels, or of collateral compounds involved in a signal pathway. Further, the expression of genes that are up- or down-regulated in response to the signal pathway can also be assayed. In this embodiment, the regulatory regions of these genes can be operably linked to a reporter gene such as luciferase.
• Modulators of variant gene expression can be identified in a method wherein, for example, a cell is contacted with a candidate compound/agent and the expression of mRNA determined. The level of expression of mRNA in the presence of the candidate compound is compared to the level of expression of mRNA in the absence of the candidate compound. The candidate compound can then be identified as a modulator of variant gene expression based on this comparison and be used to treat a disorder such as CVD that is characterized by variant gene expression (e.g., either expression of a SNP-containing nucleic acid or altered expression of a normal/wild-type nucleic acid molecule due to one or more SNPs that affect expression of the nucleic acid molecule) due to one or more SNPs of the present invention. When expression of mRNA is statistically significantly greater in the presence of the candidate compound than in its absence, the candidate compound is identified as a stimulator of nucleic acid expression. When nucleic acid expression is statistically significantly less in the presence of the candidate compound than in its absence, the candidate compound is identified as an inhibitor of nucleic acid expression.
• The invention further provides methods of treatment, with the SNP or associated nucleic acid domain (e.g., catalytic domain, ligand/substrate-binding domain, regulatory/control region, etc.) or gene, or the encoded mRNA transcript, as a target, using a compound identified through drug screening as a gene modulator to modulate variant nucleic acid expression. Modulation can include either up-regulation (i.e., activation or agonization) or down-regulation (i.e., suppression or antagonization) of nucleic acid expression.
• Expression of mRNA transcripts and encoded proteins, either wild type or variant, may be altered in individuals with a particular SNP allele in a regulatory/control element, such as a promoter or transcription factor binding domain, that regulates expression. In this situation, methods of treatment and compounds can be identified, as discussed herein, that regulate or overcome the variant regulatory/control element, thereby generating normal, or healthy, expression levels of either the wild type or variant protein.
• Pharmaceutical Compositions and Administration Thereof
• Any of the statin response-associated proteins, and encoding nucleic acid molecules, disclosed herein can be used as therapeutic targets (or directly used themselves as therapeutic compounds) for treating or preventing CVD, and the present disclosure enables therapeutic compounds (e.g., small molecules, antibodies, therapeutic proteins, RNAi and antisense molecules, etc.) to be developed that target (or are comprised of) any of these therapeutic targets.
• In general, a therapeutic compound will be administered in a therapeutically effective amount by any of the accepted modes of administration for agents that serve similar utilities. The actual amount of the therapeutic compound of this invention, i.e., the active ingredient, will depend upon numerous factors such as the severity of the disease to be treated, the age and relative health of the subject, the potency of the compound used, the route and form of administration, and other factors.
• Therapeutically effective amounts of therapeutic compounds may range from, for example, approximately 0.01-50 mg per kilogram body weight of the recipient per day; preferably about 0.1-20 mg/kg/day. Thus, as an example, for administration to a 70-kg person, the dosage range would most preferably be about 7 mg to 1.4 g per day.
• In general, therapeutic compounds will be administered as pharmaceutical compositions by any one of the following routes: oral, systemic (e.g., transdermal, intranasal, or by suppository), or parenteral (e.g., intramuscular, intravenous, or subcutaneous) administration. The preferred manner of administration is oral or parenteral using a convenient daily dosage regimen, which can be adjusted according to the degree of affliction. Oral compositions can take the form of tablets, pills, capsules, semisolids, powders, sustained release formulations, solutions, suspensions, elixirs, aerosols, or any other appropriate compositions.
• The choice of formulation depends on various factors such as the mode of drug administration (e.g., for oral administration, formulations in the form of tablets, pills, or capsules are preferred) and the bioavailability of the drug substance. Recently, pharmaceutical formulations have been developed especially for drugs that show poor bioavailability based upon the principle that bioavailability can be increased by increasing the surface area, i.e., decreasing particle size. For example, U.S. Pat. No. 4,107,288 describes a pharmaceutical formulation having particles in the size range from 10 to 1,000 nm in which the active material is supported on a cross-linked matrix of macromolecules. U.S. Pat. No. 5,145,684 describes the production of a pharmaceutical formulation in which the drug substance is pulverized to nanoparticles (average particle size of 400 nm) in the presence of a surface modifier and then dispersed in a liquid medium to give a pharmaceutical formulation that exhibits remarkably high bioavailability.
• Pharmaceutical compositions are comprised of, in general, a therapeutic compound in combination with at least one pharmaceutically acceptable excipient. Acceptable excipients are non-toxic, aid administration, and do not adversely affect the therapeutic benefit of the therapeutic compound. Such excipients may be any solid, liquid, semi-solid or, in the case of an aerosol composition, gaseous excipient that is generally available to one skilled in the art.
• Solid pharmaceutical excipients include starch, cellulose, talc, glucose, lactose, sucrose, gelatin, malt, rice, flour, chalk, silica gel, magnesium stearate, sodium stearate, glycerol monostearate, sodium chloride, dried skim milk and the like. Liquid and semisolid excipients may be selected from glycerol, propylene glycol, water, ethanol and various oils, including those of petroleum, animal, vegetable or synthetic origin, e.g., peanut oil, soybean oil, mineral oil, sesame oil, etc. Preferred liquid carriers, particularly for injectable solutions, include water, saline, aqueous dextrose, and glycols.
• Compressed gases may be used to disperse a compound of this invention in aerosol form. Inert gases suitable for this purpose are nitrogen, carbon dioxide, etc.
• Other suitable pharmaceutical excipients and their formulations are described in Remington's Pharmaceutical Sciences 18^th ed., E. W. Martin, ed., Mack Publishing Company (1990).
• The amount of the therapeutic compound in a formulation can vary within the full range employed by those skilled in the art. Typically, the formulation will contain, on a weight percent (wt %) basis, from about 0.01-99.99 wt % of the therapeutic compound based on the total formulation, with the balance being one or more suitable pharmaceutical excipients. Preferably, the compound is present at a level of about 1-80% wt.
• Therapeutic compounds can be administered alone or in combination with other therapeutic compounds or in combination with one or more other active ingredient(s). For example, an inhibitor or stimulator of a CVD-associated protein can be administered in combination with another agent that inhibits or stimulates the activity of the same or a different CVD-associated protein to thereby counteract the effects of CVD.
• For further information regarding pharmacology, see Current Protocols in Pharmacology, John Wiley & Sons, Inc., N.Y.
• Nucleic Acid-Based Therapeutic Agents
• The SNP-containing nucleic acid molecules disclosed herein, and their complementary nucleic acid molecules, may be used as antisense constructs to control gene expression in cells, tissues, and organisms. Antisense technology is well established in the art and extensively reviewed in Antisense Drug Technology: Principles, Strategies, and Applications, Crooke, ed., Marcel Dekker, Inc., N.Y. (2001). An antisense nucleic acid molecule is generally designed to be complementary to a region of mRNA expressed by a gene so that the antisense molecule hybridizes to the mRNA and thereby blocks translation of mRNA into protein. Various classes of antisense oligonucleotides are used in the art, two of which are cleavers and blockers. Cleavers, by binding to target RNAs, activate intracellular nucleases (e.g., RNaseH or RNase L) that cleave the target RNA. Blockers, which also bind to target RNAs, inhibit protein translation through steric hindrance of ribosomes. Exemplary blockers include peptide nucleic acids, morpholinos, locked nucleic acids, and methylphosphonates. See, e.g., Thompson, Drug Discovery Today 7(17): 912-917 (2002). Antisense oligonucleotides are directly useful as therapeutic agents, and are also useful for determining and validating gene function (e.g., in gene knock-out or knock-down experiments).
• Antisense technology is further reviewed in: Lavery et al., “Antisense and RNAi: powerful tools in drug target discovery and validation,” Curr Opin Drug Discov Devel 6(4):561-9 (July 2003); Stephens et al., “Antisense oligonucleotide therapy in cancer,” Curr Opin Mol Ther 5(2):118-22 (April 2003); Kurreck, “Antisense technologies. Improvement through novel chemical modifications,” Eur J Biochem 270(8):1628-44 (April 2003); Dias et al., “Antisense oligonucleotides: basic concepts and mechanisms,” Mol Cancer Ther 1(5):347-55 (March 2002); Chen, “Clinical development of antisense oligonucleotides as anti-cancer therapeutics,” Methods Mol Med 75:621-36 (2003); Wang et al., “Antisense anticancer oligonucleotide therapeutics,” Curr Cancer Drug Targets 1(3):177-96 (November 2001); and Bennett, “Efficiency of antisense oligonucleotide drug discovery,” Antisense Nucleic Acid Drug Dev 12(3):215-24 (June 2002).
• The SNPs of the present invention are particularly useful for designing antisense reagents that are specific for particular nucleic acid variants. Based on the SNP information disclosed herein, antisense oligonucleotides can be produced that specifically target mRNA molecules that contain one or more particular SNP nucleotides. In this manner, expression of mRNA molecules that contain one or more undesired polymorphisms (e.g., SNP nucleotides that lead to a defective protein such as an amino acid substitution in a catalytic domain) can be inhibited or completely blocked. Thus, antisense oligonucleotides can be used to specifically bind a particular polymorphic form (e.g., a SNP allele that encodes a defective protein), thereby inhibiting translation of this form, but which do not bind an alternative polymorphic form (e.g., an alternative SNP nucleotide that encodes a protein having normal function).
• Antisense molecules can be used to inactivate mRNA in order to inhibit gene expression and production of defective proteins. Accordingly, these molecules can be used to treat a disorder, such as CVD, characterized by abnormal or undesired gene expression or expression of certain defective proteins. This technique can involve cleavage by means of ribozymes containing nucleotide sequences complementary to one or more regions in the mRNA that attenuate the ability of the mRNA to be translated. Possible mRNA regions include, for example, protein-coding regions and particularly protein-coding regions corresponding to catalytic activities, substrate/ligand binding, or other functional activities of a protein.
• The SNPs of the present invention are also useful for designing RNA interference reagents that specifically target nucleic acid molecules having particular SNP variants. RNA interference (RNAi), also referred to as gene silencing, is based on using double-stranded RNA (dsRNA) molecules to turn genes off. When introduced into a cell, dsRNAs are processed by the cell into short fragments (generally about 21, 22, or 23 nucleotides in length) known as small interfering RNAs (siRNAs) which the cell uses in a sequence-specific manner to recognize and destroy complementary RNAs. Thompson, Drug Discovery Today 7(17): 912-917 (2002). Accordingly, an aspect of the present invention specifically contemplates isolated nucleic acid molecules that are about 18-26 nucleotides in length, preferably 19-25 nucleotides in length, and more preferably 20, 21, 22, or 23 nucleotides in length, and the use of these nucleic acid molecules for RNAi. Because RNAi molecules, including siRNAs, act in a sequence-specific manner, the SNPs of the present invention can be used to design RNAi reagents that recognize and destroy nucleic acid molecules having specific SNP alleles/nucleotides (such as deleterious alleles that lead to the production of defective proteins), while not affecting nucleic acid molecules having alternative SNP alleles (such as alleles that encode proteins having normal function). As with antisense reagents, RNAi reagents may be directly useful as therapeutic agents (e.g., for turning off defective, disease-causing genes), and are also useful for characterizing and validating gene function (e.g., in gene knock-out or knock-down experiments).
• The following references provide a further review of RNAi: Reynolds et al., “Rational siRNA design for RNA interference,” Nat Biotechnol 22(3):326-30 (March 2004); Epub Feb. 1, 2004; Chi et al., “Genomewide view of gene silencing by small interfering RNAs,” PNAS 100(11):6343-6346 (2003); Vickers et al., “Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents,” J Biol Chem 278:7108-7118 (2003); Agami, “RNAi and related mechanisms and their potential use for therapy,” Curr Opin Chem Biol 6(6):829-34 (December 2002); Lavery et al., “Antisense and RNAi: powerful tools in drug target discovery and validation,” Curr Opin Drug Discov Devel 6(4):561-9 (July 2003); Shi, “Mammalian RNAi for the masses,” Trends Genet 19(1):9-12 (January 2003); Shuey et al., “RNAi: gene-silencing in therapeutic intervention,” Drug Discovery Today 7(20):1040-1046 (October 2002); McManus et al., Nat Rev Genet 3(10):737-47 (October 2002); Xia et al., Nat Biotechnol 20(10):1006-10 (October 2002); Plasterk et al., Curr Opin Genet Dev 10(5):562-7 (October 2000); Bosher et al., Nat Cell Biol 2(2):E31-6 (February 2000); and Hunter, Curr Biol 17; 9(12):R440-2 (June 1999).
• Other Therapeutic Aspects
• SNPs have many important uses in drug discovery, screening, and development, and thus the SNPs of the present invention are useful for improving many different aspects of the drug development process.
• For example, a high probability exists that, for any gene/protein selected as a potential drug target, variants of that gene/protein will exist in a patient population. Thus, determining the impact of gene/protein variants on the selection and delivery of a therapeutic agent should be an integral aspect of the drug discovery and development process. Jazwinska, A Trends Guide to Genetic Variation and Genomic Medicine S30-S36 (March 2002).
• Knowledge of variants (e.g., SNPs and any corresponding amino acid polymorphisms) of a particular therapeutic target (e.g., a gene, mRNA transcript, or protein) enables parallel screening of the variants in order to identify therapeutic candidates (e.g., small molecule compounds, antibodies, antisense or RNAi nucleic acid compounds, etc.) that demonstrate efficacy across variants. Rothberg, Nat Biotechnol 19(3):209-11 (March 2001). Such therapeutic candidates would be expected to show equal efficacy across a larger segment of the patient population, thereby leading to a larger potential market for the therapeutic candidate.
• Furthermore, identifying variants of a potential therapeutic target enables the most common form of the target to be used for selection of therapeutic candidates, thereby helping to ensure that the experimental activity that is observed for the selected candidates reflects the real activity expected in the largest proportion of a patient population. Jazwinska, A Trends Guide to Genetic Variation and Genomic Medicine S30-S36 (March 2002).
• Additionally, screening therapeutic candidates against all known variants of a target can enable the early identification of potential toxicities and adverse reactions relating to particular variants. For example, variability in drug absorption, distribution, metabolism and excretion (ADME) caused by, for example, SNPs in therapeutic targets or drug metabolizing genes, can be identified, and this information can be utilized during the drug development process to minimize variability in drug disposition and develop therapeutic agents that are safer across a wider range of a patient population. The SNPs of the present invention, including the variant proteins and encoding polymorphic nucleic acid molecules provided in Tables 1 and 2, are useful in conjunction with a variety of toxicology methods established in the art, such as those set forth in Current Protocols in Toxicology, John Wiley & Sons, Inc., N.Y.
• Furthermore, therapeutic agents that target any art-known proteins (or nucleic acid molecules, either RNA or DNA) may cross-react with the variant proteins (or polymorphic nucleic acid molecules) disclosed in Table 1, thereby significantly affecting the pharmacokinetic properties of the drug. Consequently, the protein variants and the SNP-containing nucleic acid molecules disclosed in Tables 1 and 2 are useful in developing, screening, and evaluating therapeutic agents that target corresponding art-known protein forms (or nucleic acid molecules). Additionally, as discussed above, knowledge of all polymorphic forms of a particular drug target enables the design of therapeutic agents that are effective against most or all such polymorphic forms of the drug target.
• A subject suffering from a pathological condition ascribed to a SNP, such as CVD, may be treated so as to correct the genetic defect. See Kren et al., Proc Natl Acad Sci USA 96:10349-10354 (1999). Such a subject can be identified by any method that can detect the polymorphism in a biological sample drawn from the subject. Such a genetic defect may be permanently corrected by administering to such a subject a nucleic acid fragment incorporating a repair sequence that supplies the normal/wild-type nucleotide at the position of the SNP. This site-specific repair sequence can encompass an RNA/DNA oligonucleotide that operates to promote endogenous repair of a subject's genomic DNA. The site-specific repair sequence is administered in an appropriate vehicle, such as a complex with polyethylenimine, encapsulated in anionic liposomes, a viral vector such as an adenovirus, or other pharmaceutical composition that promotes intracellular uptake of the administered nucleic acid. A genetic defect leading to an inborn pathology may then be overcome, as the chimeric oligonucleotides induce incorporation of the normal sequence into the subject's genome. Upon incorporation, the normal gene product is expressed, and the replacement is propagated, thereby engendering a permanent repair and therapeutic enhancement of the clinical condition of the subject.
• In cases in which a cSNP results in a variant protein that is ascribed to be the cause of, or a contributing factor to, a pathological condition, a method of treating such a condition can include administering to a subject experiencing the pathology the wild-type/normal cognate of the variant protein. Once administered in an effective dosing regimen, the wild-type cognate provides complementation or remediation of the pathological condition.
• Variant Proteins, Antibodies, Vectors, Host Cells, & Uses Thereof
• Variant Proteins Encoded by SNP-Containing Nucleic Acid Molecules
• The present invention provides SNP-containing nucleic acid molecules, many of which encode proteins having variant amino acid sequences as compared to the art-known (i.e., wild-type) proteins. Amino acid sequences encoded by the polymorphic nucleic acid molecules of the present invention are referred to as SEQ ID NOS:52-102 in Table 1 and provided in the Sequence Listing. These variants will generally be referred to herein as variant proteins/peptides/polypeptides, or polymorphic proteins/peptides/polypeptides of the present invention. The terms “protein,” “peptide,” and “polypeptide” are used herein interchangeably.
• A variant protein of the present invention may be encoded by, for example, a nonsynonymous nucleotide substitution at any one of the cSNP positions disclosed herein. In addition, variant proteins may also include proteins whose expression, structure, and/or function is altered by a SNP disclosed herein, such as a SNP that creates or destroys a stop codon, a SNP that affects splicing, and a SNP in control/regulatory elements, e.g. promoters, enhancers, or transcription factor binding domains.
• As used herein, a protein or peptide is said to be “isolated” or “purified” when it is substantially free of cellular material or chemical precursors or other chemicals. The variant proteins of the present invention can be purified to homogeneity or other lower degrees of purity. The level of purification will be based on the intended use. The key feature is that the preparation allows for the desired function of the variant protein, even if in the presence of considerable amounts of other components.
• As used herein, “substantially free of cellular material” includes preparations of the variant protein having less than about 30% (by dry weight) other proteins (i.e., contaminating protein), less than about 20% other proteins, less than about 10% other proteins, or less than about 5% other proteins. When the variant protein is recombinantly produced, it can also be substantially free of culture medium, i.e., culture medium represents less than about 20% of the volume of the protein preparation.
• The language “substantially free of chemical precursors or other chemicals” includes preparations of the variant protein in which it is separated from chemical precursors or other chemicals that are involved in its synthesis. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of the variant protein having less than about 30% (by dry weight) chemical precursors or other chemicals, less than about 20% chemical precursors or other chemicals, less than about 10% chemical precursors or other chemicals, or less than about 5% chemical precursors or other chemicals.
• An isolated variant protein may be purified from cells that naturally express it, purified from cells that have been altered to express it (recombinant host cells), or synthesized using known protein synthesis methods. For example, a nucleic acid molecule containing SNP(s) encoding the variant protein can be cloned into an expression vector, the expression vector introduced into a host cell, and the variant protein expressed in the host cell. The variant protein can then be isolated from the cells by any appropriate purification scheme using standard protein purification techniques. Examples of these techniques are described in detail below. Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, N.Y. (2000).
• The present invention provides isolated variant proteins that comprise, consist of or consist essentially of amino acid sequences that contain one or more variant amino acids encoded by one or more codons that contain a SNP of the present invention.
• Accordingly, the present invention provides variant proteins that consist of amino acid sequences that contain one or more amino acid polymorphisms (or truncations or extensions due to creation or destruction of a stop codon, respectively) encoded by the SNPs provided in Table 1 and/or Table 2. A protein consists of an amino acid sequence when the amino acid sequence is the entire amino acid sequence of the protein.
• The present invention further provides variant proteins that consist essentially of amino acid sequences that contain one or more amino acid polymorphisms (or truncations or extensions due to creation or destruction of a stop codon, respectively) encoded by the SNPs provided in Table 1 and/or Table 2. A protein consists essentially of an amino acid sequence when such an amino acid sequence is present with only a few additional amino acid residues in the final protein.
• The present invention further provides variant proteins that comprise amino acid sequences that contain one or more amino acid polymorphisms (or truncations or extensions due to creation or destruction of a stop codon, respectively) encoded by the SNPs provided in Table 1 and/or Table 2. A protein comprises an amino acid sequence when the amino acid sequence is at least part of the final amino acid sequence of the protein. In such a fashion, the protein may contain only the variant amino acid sequence or have additional amino acid residues, such as a contiguous encoded sequence that is naturally associated with it or heterologous amino acid residues. Such a protein can have a few additional amino acid residues or can comprise many more additional amino acids. A brief description of how various types of these proteins can be made and isolated is provided below.
• The variant proteins of the present invention can be attached to heterologous sequences to form chimeric or fusion proteins. Such chimeric and fusion proteins comprise a variant protein operatively linked to a heterologous protein having an amino acid sequence not substantially homologous to the variant protein. “Operatively linked” indicates that the coding sequences for the variant protein and the heterologous protein are ligated in-frame. The heterologous protein can be fused to the N-terminus or C-terminus of the variant protein. In another embodiment, the fusion protein is encoded by a fusion polynucleotide that is synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and re-amplified to generate a chimeric gene sequence. See Ausubel et al., Current Protocols in Molecular Biology (1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST protein). A variant protein-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the variant protein.
• In many uses, the fusion protein does not affect the activity of the variant protein. The fusion protein can include, but is not limited to, enzymatic fusion proteins, for example, beta-galactosidase fusions, yeast two-hybrid GAL fusions, poly-His fusions, MYC-tagged, HI-tagged and Ig fusions. Such fusion proteins, particularly poly-His fusions, can facilitate their purification following recombinant expression. In certain host cells (e.g., mammalian host cells), expression and/or secretion of a protein can be increased by using a heterologous signal sequence. Fusion proteins are further described in, for example, Terpe, “Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems,” Appl Microbiol Biotechnol 60(5):523-33 (January 2003); Epub Nov. 7, 2002; Graddis et al., “Designing proteins that work using recombinant technologies,” Curr Pharm Biotechnol 3(4):285-97 (December 2002); and Nilsson et al., “Affinity fusion strategies for detection, purification, and immobilization of recombinant proteins,” Protein Expr Purif 11(1):1-16 (October 1997).
• In certain embodiments, novel compositions of the present invention also relate to further obvious variants of the variant polypeptides of the present invention, such as naturally-occurring mature forms (e.g., allelic variants), non-naturally occurring recombinantly-derived variants, and orthologs and paralogs of such proteins that share sequence homology. Such variants can readily be generated using art-known techniques in the fields of recombinant nucleic acid technology and protein biochemistry.
• Further variants of the variant polypeptides disclosed in Table 1 can comprise an amino acid sequence that shares at least 70-80%, 80-85%, 85-90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% sequence identity with an amino acid sequence disclosed in Table 1 (or a fragment thereof) and that includes a novel amino acid residue (allele) disclosed in Table 1 (which is encoded by a novel SNP allele). Thus, an aspect of the present invention that is specifically contemplated are polypeptides that have a certain degree of sequence variation compared with the polypeptide sequences shown in Table 1, but that contain a novel amino acid residue (allele) encoded by a novel SNP allele disclosed herein. In other words, as long as a polypeptide contains a novel amino acid residue disclosed herein, other portions of the polypeptide that flank the novel amino acid residue can vary to some degree from the polypeptide sequences shown in Table 1.
• Full-length pre-processed forms, as well as mature processed forms, of proteins that comprise one of the amino acid sequences disclosed herein can readily be identified as having complete sequence identity to one of the variant proteins of the present invention as well as being encoded by the same genetic locus as the variant proteins provided herein.
• Orthologs of a variant peptide can readily be identified as having some degree of significant sequence homology/identity to at least a portion of a variant peptide as well as being encoded by a gene from another organism. Preferred orthologs will be isolated from non-human mammals, preferably primates, for the development of human therapeutic targets and agents. Such orthologs can be encoded by a nucleic acid sequence that hybridizes to a variant peptide-encoding nucleic acid molecule under moderate to stringent conditions depending on the degree of relatedness of the two organisms yielding the homologous proteins.
• Variant proteins include, but are not limited to, proteins containing deletions, additions and substitutions in the amino acid sequence caused by the SNPs of the present invention. One class of substitutions is conserved amino acid substitutions in which a given amino acid in a polypeptide is substituted for another amino acid of like characteristics. Typical conservative substitutions are replacements, one for another, among the aliphatic amino acids Ala, Val, Leu, and Ile; interchange of the hydroxyl residues Ser and Thr; exchange of the acidic residues Asp and Glu; substitution between the amide residues Asn and Gln; exchange of the basic residues Lys and Arg; and replacements among the aromatic residues Phe and Tyr. Guidance concerning which amino acid changes are likely to be phenotypically silent are found, for example, in Bowie et al., Science 247:1306-1310 (1990).
• Variant proteins can be fully functional or can lack function in one or more activities, e.g. ability to bind another molecule, ability to catalyze a substrate, ability to mediate signaling, etc. Fully functional variants typically contain only conservative variations or variations in non-critical residues or in non-critical regions. Functional variants can also contain substitution of similar amino acids that result in no change or an insignificant change in function. Alternatively, such substitutions may positively or negatively affect function to some degree. Non-functional variants typically contain one or more non-conservative amino acid substitutions, deletions, insertions, inversions, truncations or extensions, or a substitution, insertion, inversion, or deletion of a critical residue or in a critical region.
• Amino acids that are essential for function of a protein can be identified by methods known in the art, such as site-directed mutagenesis or alanine-scanning mutagenesis, particularly using the amino acid sequence and polymorphism information provided in Table 1. Cunningham et al., Science 244:1081-1085 (1989). The latter procedure introduces single alanine mutations at every residue in the molecule. The resulting mutant molecules are then tested for biological activity such as enzyme activity or in assays such as an in vitro proliferative activity. Sites that are critical for binding partner/substrate binding can also be determined by structural analysis such as crystallization, nuclear magnetic resonance or photoaffinity labeling. Smith et al., J Mol Biol 224:899-904 (1992); de Vos et al., Science 255:306-312 (1992).
• Polypeptides can contain amino acids other than the 20 amino acids commonly referred to as the 20 naturally occurring amino acids. Further, many amino acids, including the terminal amino acids, may be modified by natural processes, such as processing and other post-translational modifications, or by chemical modification techniques well known in the art. Accordingly, the variant proteins of the present invention also encompass derivatives or analogs in which a substituted amino acid residue is not one encoded by the genetic code, in which a substituent group is included, in which the mature polypeptide is fused with another compound, such as a compound to increase the half-life of the polypeptide (e.g., polyethylene glycol), or in which additional amino acids are fused to the mature polypeptide, such as a leader or secretory sequence or a sequence for purification of the mature polypeptide or a pro-protein sequence.
• Known protein modifications include, but are not limited to, acetylation, acylation, ADP-ribosylation, amidation, covalent attachment of flavin, covalent attachment of a heme moiety, covalent attachment of a nucleotide or nucleotide derivative, covalent attachment of a lipid or lipid derivative, covalent attachment of phosphotidylinositol, cross-linking, cyclization, disulfide bond formation, demethylation, formation of covalent crosslinks, formation of cystine, formation of pyroglutamate, formylation, gamma carboxylation, glycosylation, GPI anchor formation, hydroxylation, iodination, methylation, myristoylation, oxidation, proteolytic processing, phosphorylation, prenylation, racemization, selenoylation, sulfation, transfer-RNA mediated addition of amino acids to proteins such as arginylation, and ubiquitination.
• Such protein modifications are well known to those of skill in the art and have been described in great detail in the scientific literature. Particularly common modifications, for example glycosylation, lipid attachment, sulfation, gamma-carboxylation of glutamic acid residues, hydroxylation and ADP-ribosylation, are described in most basic texts, such as Proteins—Structure and Molecular Properties 2nd Ed., T. E. Creighton, W.H. Freeman and Company, N.Y. (1993); F. Wold, Posttranslational Covalent Modification of Proteins 1-12, B. C. Johnson, ed., Academic Press, N.Y. (1983); Seifter et al., Meth Enzymol 182:626-646 (1990); and Rattan et al., Ann NY Acad Sci 663:48-62 (1992).
• The present invention further provides fragments of the variant proteins in which the fragments contain one or more amino acid sequence variations (e.g., substitutions, or truncations or extensions due to creation or destruction of a stop codon) encoded by one or more SNPs disclosed herein. The fragments to which the invention pertains, however, are not to be construed as encompassing fragments that have been disclosed in the prior art before the present invention.
• As used herein, a fragment may comprise at least about 4, 8, 10, 12, 14, 16, 18, 20, 25, 30, 50, 100 (or any other number in-between) or more contiguous amino acid residues from a variant protein, wherein at least one amino acid residue is affected by a SNP of the present invention, e.g., a variant amino acid residue encoded by a nonsynonymous nucleotide substitution at a cSNP position provided by the present invention. The variant amino acid encoded by a cSNP may occupy any residue position along the sequence of the fragment. Such fragments can be chosen based on the ability to retain one or more of the biological activities of the variant protein or the ability to perform a function, e.g., act as an immunogen. Particularly important fragments are biologically active fragments. Such fragments will typically comprise a domain or motif of a variant protein of the present invention, e.g., active site, transmembrane domain, or ligand/substrate binding domain. Other fragments include, but are not limited to, domain or motif-containing fragments, soluble peptide fragments, and fragments containing immunogenic structures. Predicted domains and functional sites are readily identifiable by computer programs well known to those of skill in the art (e.g., PROSITE analysis). Current Protocols in Protein Science, John Wiley & Sons, N.Y. (2002).
• Uses of Variant Proteins
• The variant proteins of the present invention can be used in a variety of ways, including but not limited to, in assays to determine the biological activity of a variant protein, such as in a panel of multiple proteins for high-throughput screening; to raise antibodies or to elicit another type of immune response; as a reagent (including the labeled reagent) in assays designed to quantitatively determine levels of the variant protein (or its binding partner) in biological fluids; as a marker for cells or tissues in which it is preferentially expressed (either constitutively or at a particular stage of tissue differentiation or development or in a disease state); as a target for screening for a therapeutic agent; and as a direct therapeutic agent to be administered into a human subject. Any of the variant proteins disclosed herein may be developed into reagent grade or kit format for commercialization as research products. Methods for performing the uses listed above are well known to those skilled in the art. See, e.g., Molecular Cloning: A Laboratory Manual, Sambrook and Russell, Cold Spring Harbor Laboratory Press, N.Y. (2000), and Methods in Enzymology: Guide to Molecular Cloning Techniques, S. L. Berger and A. R. Kimmel, eds., Academic Press (1987).
• In a specific embodiment of the invention, the methods of the present invention include detection of one or more variant proteins disclosed herein. Variant proteins are disclosed in Table 1 and in the Sequence Listing as SEQ ID NOS:52-102. Detection of such proteins can be accomplished using, for example, antibodies, small molecule compounds, aptamers, ligands/substrates, other proteins or protein fragments, or other protein-binding agents. Preferably, protein detection agents are specific for a variant protein of the present invention and can therefore discriminate between a variant protein of the present invention and the wild-type protein or another variant form. This can generally be accomplished by, for example, selecting or designing detection agents that bind to the region of a protein that differs between the variant and wild-type protein, such as a region of a protein that contains one or more amino acid substitutions that is/are encoded by a non-synonymous cSNP of the present invention, or a region of a protein that follows a nonsense mutation-type SNP that creates a stop codon thereby leading to a shorter polypeptide, or a region of a protein that follows a read-through mutation-type SNP that destroys a stop codon thereby leading to a longer polypeptide in which a portion of the polypeptide is present in one version of the polypeptide but not the other.
• In another aspect of the invention, variant proteins of the present invention can be used as targets for predicting an individual's response to statin treatment (particularly for reducing the risk of CVD, especially CHD such as MI), for determining predisposition to CVD (particularly CHD, such as MI), for diagnosing CVD, or for treating and/or preventing CVD, etc. Accordingly, the invention provides methods for detecting the presence of, or levels of, one or more variant proteins of the present invention in a cell, tissue, or organism. Such methods typically involve contacting a test sample with an agent (e.g., an antibody, small molecule compound, or peptide) capable of interacting with the variant protein such that specific binding of the agent to the variant protein can be detected. Such an assay can be provided in a single detection format or a multi-detection format such as an array, for example, an antibody or aptamer array (arrays for protein detection may also be referred to as “protein chips”). The variant protein of interest can be isolated from a test sample and assayed for the presence of a variant amino acid sequence encoded by one or more SNPs disclosed by the present invention. The SNPs may cause changes to the protein and the corresponding protein function/activity, such as through non-synonymous substitutions in protein coding regions that can lead to amino acid substitutions, deletions, insertions, and/or rearrangements; formation or destruction of stop codons; or alteration of control elements such as promoters. SNPs may also cause inappropriate post-translational modifications.
• One preferred agent for detecting a variant protein in a sample is an antibody capable of selectively binding to a variant form of the protein (antibodies are described in greater detail in the next section). Such samples include, for example, tissues, cells, and biological fluids isolated from a subject, as well as tissues, cells and fluids present within a subject.
• In vitro methods for detection of the variant proteins associated with statin response that are disclosed herein and fragments thereof include, but are not limited to, enzyme linked immunosorbent assays (ELISAs), radioimmunoassays (RIA), Western blots, immunoprecipitations, immunofluorescence, and protein arrays/chips (e.g., arrays of antibodies or aptamers). For further information regarding immunoassays and related protein detection methods, see Current Protocols in Immunology, John Wiley & Sons, N. Y., and Hage, “Immunoassays,” Anal Chem 15; 71(12):294R-304R (June 1999).
• Additional analytic methods of detecting amino acid variants include, but are not limited to, altered electrophoretic mobility, altered tryptic peptide digest, altered protein activity in cell-based or cell-free assay, alteration in ligand or antibody-binding pattern, altered isoelectric point, and direct amino acid sequencing.
• Alternatively, variant proteins can be detected in vivo in a subject by introducing into the subject a labeled antibody (or other type of detection reagent) specific for a variant protein. For example, the antibody can be labeled with a radioactive marker whose presence and location in a subject can be detected by standard imaging techniques.
• Other uses of the variant peptides of the present invention are based on the class or action of the protein. For example, proteins isolated from humans and their mammalian orthologs serve as targets for identifying agents (e.g., small molecule drugs or antibodies) for use in therapeutic applications, particularly for modulating a biological or pathological response in a cell or tissue that expresses the protein. Pharmaceutical agents can be developed that modulate protein activity.
• As an alternative to modulating gene expression, therapeutic compounds can be developed that modulate protein function. For example, many SNPs disclosed herein affect the amino acid sequence of the encoded protein (e.g., non-synonymous cSNPs and nonsense mutation-type SNPs). Such alterations in the encoded amino acid sequence may affect protein function, particularly if such amino acid sequence variations occur in functional protein domains, such as catalytic domains, ATP-binding domains, or ligand/substrate binding domains. It is well established in the art that variant proteins having amino acid sequence variations in functional domains can cause or influence pathological conditions. In such instances, compounds (e.g., small molecule drugs or antibodies) can be developed that target the variant protein and modulate (e.g., up- or down-regulate) protein function/activity.
• The therapeutic methods of the present invention further include methods that target one or more variant proteins of the present invention. Variant proteins can be targeted using, for example, small molecule compounds, antibodies, aptamers, ligands/substrates, other proteins, or other protein-binding agents. Additionally, the skilled artisan will recognize that the novel protein variants (and polymorphic nucleic acid molecules) disclosed in Table 1 may themselves be directly used as therapeutic agents by acting as competitive inhibitors of corresponding art-known proteins (or nucleic acid molecules such as mRNA molecules).
• The variant proteins of the present invention are particularly useful in drug screening assays, in cell-based or cell-free systems. Cell-based systems can utilize cells that naturally express the protein, a biopsy specimen, or cell cultures. In one embodiment, cell-based assays involve recombinant host cells expressing the variant protein. Cell-free assays can be used to detect the ability of a compound to directly bind to a variant protein or to the corresponding SNP-containing nucleic acid fragment that encodes the variant protein.
• A variant protein of the present invention, as well as appropriate fragments thereof, can be used in high-throughput screening assays to test candidate compounds for the ability to bind and/or modulate the activity of the variant protein. These candidate compounds can be further screened against a protein having normal function (e.g., a wild-type/non-variant protein) to further determine the effect of the compound on the protein activity. Furthermore, these compounds can be tested in animal or invertebrate systems to determine in vivo activity/effectiveness. Compounds can be identified that activate (agonists) or inactivate (antagonists) the variant protein, and different compounds can be identified that cause various degrees of activation or inactivation of the variant protein.
• Further, the variant proteins can be used to screen a compound for the ability to stimulate or inhibit interaction between the variant protein and a target molecule that normally interacts with the protein. The target can be a ligand, a substrate or a binding partner that the protein normally interacts with (for example, epinephrine or norepinephrine). Such assays typically include the steps of combining the variant protein with a candidate compound under conditions that allow the variant protein, or fragment thereof, to interact with the target molecule, and to detect the formation of a complex between the protein and the target or to detect the biochemical consequence of the interaction with the variant protein and the target, such as any of the associated effects of signal transduction.
• Candidate compounds include, for example, 1) peptides such as soluble peptides, including Ig-tailed fusion peptides and members of random peptide libraries (see, e.g., Lam et al., Nature 354:82-84 (1991); Houghten et al., Nature 354:84-86 (1991)) and combinatorial chemistry-derived molecular libraries made of D- and/or L-configuration amino acids; 2) phosphopeptides (e.g., members of random and partially degenerate, directed phosphopeptide libraries, see, e.g., Songyang et al., Cell 72:767-778 (1993)); 3) antibodies (e.g., polyclonal, monoclonal, humanized, anti-idiotypic, chimeric, and single chain antibodies as well as Fab, F(ab′)₂, Fab expression library fragments, and epitope-binding fragments of antibodies); and 4) small organic and inorganic molecules (e.g., molecules obtained from combinatorial and natural product libraries).
• One candidate compound is a soluble fragment of the variant protein that competes for ligand binding. Other candidate compounds include mutant proteins or appropriate fragments containing mutations that affect variant protein function and thus compete for ligand. Accordingly, a fragment that competes for ligand, for example with a higher affinity, or a fragment that binds ligand but does not allow release, is encompassed by the invention.
• The invention further includes other end point assays to identify compounds that modulate (stimulate or inhibit) variant protein activity. The assays typically involve an assay of events in the signal transduction pathway that indicate protein activity. Thus, the expression of genes that are up or down-regulated in response to the variant protein dependent signal cascade can be assayed. In one embodiment, the regulatory region of such genes can be operably linked to a marker that is easily detectable, such as luciferase. Alternatively, phosphorylation of the variant protein, or a variant protein target, could also be measured. Any of the biological or biochemical functions mediated by the variant protein can be used as an endpoint assay. These include all of the biochemical or biological events described herein, in the references cited herein, incorporated by reference for these endpoint assay targets, and other functions known to those of ordinary skill in the art.
• Binding and/or activating compounds can also be screened by using chimeric variant proteins in which an amino terminal extracellular domain or parts thereof, an entire transmembrane domain or subregions, and/or the carboxyl terminal intracellular domain or parts thereof, can be replaced by heterologous domains or subregions. For example, a substrate-binding region can be used that interacts with a different substrate than that which is normally recognized by a variant protein. Accordingly, a different set of signal transduction components is available as an end-point assay for activation. This allows for assays to be performed in other than the specific host cell from which the variant protein is derived.
• The variant proteins are also useful in competition binding assays in methods designed to discover compounds that interact with the variant protein. Thus, a compound can be exposed to a variant protein under conditions that allow the compound to bind or to otherwise interact with the variant protein. A binding partner, such as ligand, that normally interacts with the variant protein is also added to the mixture. If the test compound interacts with the variant protein or its binding partner, it decreases the amount of complex formed or activity from the variant protein. This type of assay is particularly useful in screening for compounds that interact with specific regions of the variant protein. Hodgson, Bio/technology, 10(9), 973-80 (September 1992).
• To perform cell-free drug screening assays, it is sometimes desirable to immobilize either the variant protein or a fragment thereof, or its target molecule, to facilitate separation of complexes from uncomplexed forms of one or both of the proteins, as well as to accommodate automation of the assay. Any method for immobilizing proteins on matrices can be used in drug screening assays. In one embodiment, a fusion protein containing an added domain allows the protein to be bound to a matrix. For example, glutathione-S-transferase/¹²⁵I fusion proteins can be adsorbed onto glutathione sepharose beads (Sigma Chemical, St. Louis, Mo.) or glutathione derivatized microtitre plates, which are then combined with the cell lysates (e.g., ³⁵S-labeled) and a candidate compound, such as a drug candidate, and the mixture incubated under conditions conducive to complex formation (e.g., at physiological conditions for salt and pH). Following incubation, the beads can be washed to remove any unbound label, and the matrix immobilized and radiolabel determined directly, or in the supernatant after the complexes are dissociated. Alternatively, the complexes can be dissociated from the matrix, separated by SDS-PAGE, and the level of bound material found in the bead fraction quantitated from the gel using standard electrophoretic techniques.
• Either the variant protein or its target molecule can be immobilized utilizing conjugation of biotin and streptavidin. Alternatively, antibodies reactive with the variant protein but which do not interfere with binding of the variant protein to its target molecule can be derivatized to the wells of the plate, and the variant protein trapped in the wells by antibody conjugation. Preparations of the target molecule and a candidate compound are incubated in the variant protein-presenting wells and the amount of complex trapped in the well can be quantitated. Methods for detecting such complexes, in addition to those described above for the GST-immobilized complexes, include immunodetection of complexes using antibodies reactive with the protein target molecule, or which are reactive with variant protein and compete with the target molecule, and enzyme-linked assays that rely on detecting an enzymatic activity associated with the target molecule.
• Modulators of variant protein activity identified according to these drug screening assays can be used to treat a subject with a disorder mediated by the protein pathway, such as CVD. These methods of treatment typically include the steps of administering the modulators of protein activity in a pharmaceutical composition to a subject in need of such treatment.
• The variant proteins, or fragments thereof, disclosed herein can themselves be directly used to treat a disorder characterized by an absence of, inappropriate, or unwanted expression or activity of the variant protein. Accordingly, methods for treatment include the use of a variant protein disclosed herein or fragments thereof.
• In yet another aspect of the invention, variant proteins can be used as “bait proteins” in a two-hybrid assay or three-hybrid assay to identify other proteins that bind to or interact with the variant protein and are involved in variant protein activity. See, e.g., U.S. Pat. No. 5,283,317; Zervos et al., Cell 72:223-232 (1993); Madura et al., J Biol Chem 268:12046-12054 (1993); Bartel et al., Biotechniques 14:920-924 (1993); Iwabuchi et al., Oncogene 8:1693-1696 (1993); and Brent, WO 94/10300. Such variant protein-binding proteins are also likely to be involved in the propagation of signals by the variant proteins or variant protein targets as, for example, elements of a protein-mediated signaling pathway. Alternatively, such variant protein-binding proteins are inhibitors of the variant protein.
• The two-hybrid system is based on the modular nature of most transcription factors, which typically consist of separable DNA-binding and activation domains. Briefly, the assay typically utilizes two different DNA constructs. In one construct, the gene that codes for a variant protein is fused to a gene encoding the DNA binding domain of a known transcription factor (e.g., GAL-4). In the other construct, a DNA sequence, from a library of DNA sequences, that encodes an unidentified protein (“prey” or “sample”) is fused to a gene that codes for the activation domain of the known transcription factor. If the “bait” and the “prey” proteins are able to interact, in vivo, forming a variant protein-dependent complex, the DNA-binding and activation domains of the transcription factor are brought into close proximity. This proximity allows transcription of a reporter gene (e.g., LacZ) that is operably linked to a transcriptional regulatory site responsive to the transcription factor. Expression of the reporter gene can be detected, and cell colonies containing the functional transcription factor can be isolated and used to obtain the cloned gene that encodes the protein that interacts with the variant protein.
• Antibodies Directed to Variant Proteins
• The present invention also provides antibodies that selectively bind to the variant proteins disclosed herein and fragments thereof. Such antibodies may be used to quantitatively or qualitatively detect the variant proteins of the present invention. As used herein, an antibody selectively binds a target variant protein when it binds the variant protein and does not significantly bind to non-variant proteins, i.e., the antibody does not significantly bind to normal, wild-type, or art-known proteins that do not contain a variant amino acid sequence due to one or more SNPs of the present invention (variant amino acid sequences may be due to, for example, nonsynonymous cSNPs, nonsense SNPs that create a stop codon, thereby causing a truncation of a polypeptide or SNPs that cause read-through mutations resulting in an extension of a polypeptide).
• As used herein, an antibody is defined in terms consistent with that recognized in the art: they are multi-subunit proteins produced by an organism in response to an antigen challenge. The antibodies of the present invention include both monoclonal antibodies and polyclonal antibodies, as well as antigen-reactive proteolytic fragments of such antibodies, such as Fab, F(ab)′₂, and Fv fragments. In addition, an antibody of the present invention further includes any of a variety of engineered antigen-binding molecules such as a chimeric antibody (U.S. Pat. Nos. 4,816,567 and 4,816,397; Morrison et al., Proc Natl Acad Sci USA 81:6851 (1984); Neuberger et al., Nature 312:604 (1984)), a humanized antibody (U.S. Pat. Nos. 5,693,762; 5,585,089 and 5,565,332), a single-chain Fv (U.S. Pat. No. 4,946,778; Ward et al., Nature 334:544 (1989)), a bispecific antibody with two binding specificities (Segal et al., J Immunol Methods 248:1 (2001); Carter, J Immunol Methods 248:7 (2001)), a diabody, a triabody, and a tetrabody (Todorovska et al., J Immunol Methods 248:47 (2001)), as well as a Fab conjugate (dimer or trimer), and a minibody.
• Many methods are known in the art for generating and/or identifying antibodies to a given target antigen. Harlow, Antibodies, Cold Spring Harbor Press, N.Y. (1989). In general, an isolated peptide (e.g., a variant protein of the present invention) is used as an immunogen and is administered to a mammalian organism, such as a rat, rabbit, hamster or mouse. Either a full-length protein, an antigenic peptide fragment (e.g., a peptide fragment containing a region that varies between a variant protein and a corresponding wild-type protein), or a fusion protein can be used. A protein used as an immunogen may be naturally-occurring, synthetic or recombinantly produced, and may be administered in combination with an adjuvant, including but not limited to, Freund's (complete and incomplete), mineral gels such as aluminum hydroxide, surface active substance such as lysolecithin, pluronic polyols, polyanions, peptides, oil emulsions, keyhole limpet hemocyanin, dinitrophenol, and the like.
• Monoclonal antibodies can be produced by hybridoma technology, which immortalizes cells secreting a specific monoclonal antibody. Kohler and Milstein, Nature 256:495 (1975). The immortalized cell lines can be created in vitro by fusing two different cell types, typically lymphocytes, and tumor cells. The hybridoma cells may be cultivated in vitro or in vivo. Additionally, fully human antibodies can be generated by transgenic animals. He et al., J Immunol 169:595 (2002). Fd phage and Fd phagemid technologies may be used to generate and select recombinant antibodies in vitro. Hoogenboom and Chames, Immunol Today 21:371 (2000); Liu et al., J Mol Biol 315:1063 (2002). The complementarity-determining regions of an antibody can be identified, and synthetic peptides corresponding to such regions may be used to mediate antigen binding. U.S. Pat. No. 5,637,677.
• Antibodies are preferably prepared against regions or discrete fragments of a variant protein containing a variant amino acid sequence as compared to the corresponding wild-type protein (e.g., a region of a variant protein that includes an amino acid encoded by a nonsynonymous cSNP, a region affected by truncation caused by a nonsense SNP that creates a stop codon, or a region resulting from the destruction of a stop codon due to read-through mutation caused by a SNP). Furthermore, preferred regions will include those involved in function/activity and/or protein/binding partner interaction. Such fragments can be selected on a physical property, such as fragments corresponding to regions that are located on the surface of the protein, e.g., hydrophilic regions, or can be selected based on sequence uniqueness, or based on the position of the variant amino acid residue(s) encoded by the SNPs provided by the present invention. An antigenic fragment will typically comprise at least about 8-10 contiguous amino acid residues in which at least one of the amino acid residues is an amino acid affected by a SNP disclosed herein. The antigenic peptide can comprise, however, at least 12, 14, 16, 20, 25, 50, 100 (or any other number in-between) or more amino acid residues, provided that at least one amino acid is affected by a SNP disclosed herein.
• Detection of an antibody of the present invention can be facilitated by coupling (i.e., physically linking) the antibody or an antigen-reactive fragment thereof to a detectable substance. Detectable substances include, but are not limited to, various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, β-galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include ¹²⁵I, ¹³¹I, ³⁵S or ³H.
• Antibodies, particularly the use of antibodies as therapeutic agents, are reviewed in: Morgan, “Antibody therapy for Alzheimer's disease,” Expert Rev Vaccines (1):53-9 (February 2003); Ross et al., “Anticancer antibodies,” Am J Clin Pathol 119(4):472-85 (April 2003); Goldenberg, “Advancing role of radiolabeled antibodies in the therapy of cancer,” Cancer Immunol Immunother 52(5):281-96 (May 2003); Epub Mar. 11, 2003; Ross et al., “Antibody-based therapeutics in oncology,” Expert Rev Anticancer Ther 3(1):107-21 (February 2003); Cao et al., “Bispecific antibody conjugates in therapeutics,” Adv Drug Deliv Rev 55(2):171-97 (February 2003); von Mehren et al., “Monoclonal antibody therapy for cancer,” Annu Rev Med 54:343-69 (2003); Epub Dec. 3, 2001; Hudson et al., “Engineered antibodies,” Nat Med 9(1):129-34 (January 2003); Brekke et al., “Therapeutic antibodies for human diseases at the dawn of the twenty-first century,” Nat Rev Drug Discov 2(1):52-62 (January 2003); Erratum in: Nat Rev Drug Discov 2(3):240 (March 2003); Houdebine, “Antibody manufacture in transgenic animals and comparisons with other systems,” Curr Opin Biotechnol 13(6):625-9 (December 2002); Andreakos et al., “Monoclonal antibodies in immune and inflammatory diseases,” Curr Opin Biotechnol 13(6):615-20 (December 2002); Kellermann et al., “Antibody discovery: the use of transgenic mice to generate human monoclonal antibodies for therapeutics,” Curr Opin Biotechnol 13(6):593-7 (December 2002); Pini et al., “Phage display and colony filter screening for high-throughput selection of antibody libraries,” Comb Chem High Throughput Screen 5(7):503-10 (November 2002); Batra et al., “Pharmacokinetics and biodistribution of genetically engineered antibodies,” Curr Opin Biotechnol 13(6):603-8 (December 2002); and Tangri et al., “Rationally engineered proteins or antibodies with absent or reduced immunogenicity,” Curr Med Chem 9(24):2191-9 (December 2002).
• Uses of Antibodies
• Antibodies can be used to isolate the variant proteins of the present invention from a natural cell source or from recombinant host cells by standard techniques, such as affinity chromatography or immunoprecipitation. In addition, antibodies are useful for detecting the presence of a variant protein of the present invention in cells or tissues to determine the pattern of expression of the variant protein among various tissues in an organism and over the course of normal development or disease progression. Further, antibodies can be used to detect variant protein in situ, in vitro, in a bodily fluid, or in a cell lysate or supernatant in order to evaluate the amount and pattern of expression. Also, antibodies can be used to assess abnormal tissue distribution, abnormal expression during development, or expression in an abnormal condition, such as in CVD, or during statin treatment. Additionally, antibody detection of circulating fragments of the full-length variant protein can be used to identify turnover.
• Antibodies to the variant proteins of the present invention are also useful in pharmacogenomic analysis. Thus, antibodies against variant proteins encoded by alternative SNP alleles can be used to identify individuals that require modified treatment modalities.
• Further, antibodies can be used to assess expression of the variant protein in disease states such as in active stages of the disease or in an individual with a predisposition to a disease related to the protein's function, such as CVD, or during the course of a treatment regime, such as during statin treatment. Antibodies specific for a variant protein encoded by a SNP-containing nucleic acid molecule of the present invention can be used to assay for the presence of the variant protein, such as to determine an individual's response to statin treatment (particularly for reducing their risk for CVD, particularly CHD, such as MI, or stroke) or to diagnose CVD or predisposition/susceptibility to CVD, as indicated by the presence of the variant protein.
• Antibodies are also useful as diagnostic tools for evaluating the variant proteins in conjunction with analysis by electrophoretic mobility, isoelectric point, tryptic peptide digest, and other physical assays well known in the art.
• Antibodies are also useful for tissue typing. Thus, where a specific variant protein has been correlated with expression in a specific tissue, antibodies that are specific for this protein can be used to identify a tissue type.
• Antibodies can also be used to assess aberrant subcellular localization of a variant protein in cells in various tissues. The diagnostic uses can be applied, not only in genetic testing, but also in monitoring a treatment modality. Accordingly, where treatment is ultimately aimed at correcting the expression level or the presence of variant protein or aberrant tissue distribution or developmental expression of a variant protein, antibodies directed against the variant protein or relevant fragments can be used to monitor therapeutic efficacy.
• The antibodies are also useful for inhibiting variant protein function, for example, by blocking the binding of a variant protein to a binding partner. These uses can also be applied in a therapeutic context in which treatment involves inhibiting a variant protein's function. An antibody can be used, for example, to block or competitively inhibit binding, thus modulating (agonizing or antagonizing) the activity of a variant protein. Antibodies can be prepared against specific variant protein fragments containing sites required for function or against an intact variant protein that is associated with a cell or cell membrane. For in vivo administration, an antibody may be linked with an additional therapeutic payload such as a radionuclide, an enzyme, an immunogenic epitope, or a cytotoxic agent. Suitable cytotoxic agents include, but are not limited to, bacterial toxin such as diphtheria, and plant toxin such as ricin. The in vivo half-life of an antibody or a fragment thereof may be lengthened by pegylation through conjugation to polyethylene glycol. Leong et al., Cytokine 16:106 (2001).
• The invention also encompasses kits for using antibodies, such as kits for detecting the presence of a variant protein in a test sample. An exemplary kit can comprise antibodies such as a labeled or labelable antibody and a compound or agent for detecting variant proteins in a biological sample; means for determining the amount, or presence/absence of variant protein in the sample; means for comparing the amount of variant protein in the sample with a standard; and instructions for use.
• Vectors and Host Cells
• The present invention also provides vectors containing the SNP-containing nucleic acid molecules described herein. The term “vector” refers to a vehicle, preferably a nucleic acid molecule, which can transport a SNP-containing nucleic acid molecule. When the vector is a nucleic acid molecule, the SNP-containing nucleic acid molecule can be covalently linked to the vector nucleic acid. Such vectors include, but are not limited to, a plasmid, single or double stranded phage, a single or double stranded RNA or DNA viral vector, or artificial chromosome, such as a BAC, PAC, YAC, or MAC.
• A vector can be maintained in a host cell as an extrachromosomal element where it replicates and produces additional copies of the SNP-containing nucleic acid molecules. Alternatively, the vector may integrate into the host cell genome and produce additional copies of the SNP-containing nucleic acid molecules when the host cell replicates.
• The invention provides vectors for the maintenance (cloning vectors) or vectors for expression (expression vectors) of the SNP-containing nucleic acid molecules. The vectors can function in prokaryotic or eukaryotic cells or in both (shuttle vectors).
• Expression vectors typically contain cis-acting regulatory regions that are operably linked in the vector to the SNP-containing nucleic acid molecules such that transcription of the SNP-containing nucleic acid molecules is allowed in a host cell. The SNP-containing nucleic acid molecules can also be introduced into the host cell with a separate nucleic acid molecule capable of affecting transcription. Thus, the second nucleic acid molecule may provide a trans-acting factor interacting with the cis-regulatory control region to allow transcription of the SNP-containing nucleic acid molecules from the vector. Alternatively, a trans-acting factor may be supplied by the host cell. Finally, a trans-acting factor can be produced from the vector itself. It is understood, however, that in some embodiments, transcription and/or translation of the nucleic acid molecules can occur in a cell-free system.
• The regulatory sequences to which the SNP-containing nucleic acid molecules described herein can be operably linked include promoters for directing mRNA transcription. These include, but are not limited to, the left promoter from bacteriophage λ, the lac, TRP, and TAC promoters from E. coli, the early and late promoters from SV40, the CMV immediate early promoter, the adenovirus early and late promoters, and retrovirus long-terminal repeats.
• In addition to control regions that promote transcription, expression vectors may also include regions that modulate transcription, such as repressor binding sites and enhancers. Examples include the SV40 enhancer, the cytomegalovirus immediate early enhancer, polyoma enhancer, adenovirus enhancers, and retrovirus LTR enhancers.
• In addition to containing sites for transcription initiation and control, expression vectors can also contain sequences necessary for transcription termination and, in the transcribed region, a ribosome-binding site for translation. Other regulatory control elements for expression include initiation and termination codons as well as polyadenylation signals. A person of ordinary skill in the art would be aware of the numerous regulatory sequences that are useful in expression vectors. See, e.g., Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, N.Y. (2000).
• A variety of expression vectors can be used to express a SNP-containing nucleic acid molecule. Such vectors include chromosomal, episomal, and virus-derived vectors, for example, vectors derived from bacterial plasmids, from bacteriophage, from yeast episomes, from yeast chromosomal elements, including yeast artificial chromosomes, from viruses such as baculoviruses, papovaviruses such as SV40, Vaccinia viruses, adenoviruses, poxviruses, pseudorabies viruses, and retroviruses. Vectors can also be derived from combinations of these sources such as those derived from plasmid and bacteriophage genetic elements, e.g., cosmids and phagemids. Appropriate cloning and expression vectors for prokaryotic and eukaryotic hosts are described in Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, N.Y. (2000).
• The regulatory sequence in a vector may provide constitutive expression in one or more host cells (e.g., tissue specific expression) or may provide for inducible expression in one or more cell types such as by temperature, nutrient additive, or exogenous factor, e.g., a hormone or other ligand. A variety of vectors that provide constitutive or inducible expression of a nucleic acid sequence in prokaryotic and eukaryotic host cells are well known to those of ordinary skill in the art.
• A SNP-containing nucleic acid molecule can be inserted into the vector by methodology well-known in the art. Generally, the SNP-containing nucleic acid molecule that will ultimately be expressed is joined to an expression vector by cleaving the SNP-containing nucleic acid molecule and the expression vector with one or more restriction enzymes and then ligating the fragments together. Procedures for restriction enzyme digestion and ligation are well known to those of ordinary skill in the art.
• The vector containing the appropriate nucleic acid molecule can be introduced into an appropriate host cell for propagation or expression using well-known techniques. Bacterial host cells include, but are not limited to, Escherichia coli, Streptomyces spp., and Salmonella typhimurium. Eukaryotic host cells include, but are not limited to, yeast, insect cells such as Drosophila spp., animal cells such as COS and CHO cells, and plant cells.
• As described herein, it may be desirable to express the variant peptide as a fusion protein. Accordingly, the invention provides fusion vectors that allow for the production of the variant peptides. Fusion vectors can, for example, increase the expression of a recombinant protein, increase the solubility of the recombinant protein, and aid in the purification of the protein by acting, for example, as a ligand for affinity purification. A proteolytic cleavage site may be introduced at the junction of the fusion moiety so that the desired variant peptide can ultimately be separated from the fusion moiety. Proteolytic enzymes suitable for such use include, but are not limited to, factor Xa, thrombin, and enterokinase. Typical fusion expression vectors include pGEX (Smith et al., Gene 67:31-40 (1988)), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. Examples of suitable inducible non-fusion E. coli expression vectors include pTrc (Amann et al., Gene 69:301-315 (1988)) and pET 11d (Studier et al., Gene Expression Technology: Methods in Enzymology 185:60-89 (1990)).
• Recombinant protein expression can be maximized in a bacterial host by providing a genetic background wherein the host cell has an impaired capacity to proteolytically cleave the recombinant protein (S. Gottesman, Gene Expression Technology: Methods in Enzymology 185:119-128, Academic Press, Calif. (1990)). Alternatively, the sequence of the SNP-containing nucleic acid molecule of interest can be altered to provide preferential codon usage for a specific host cell, for example, E. coli. Wada et al., Nucleic Acids Res 20:2111-2118 (1992).
• The SNP-containing nucleic acid molecules can also be expressed by expression vectors that are operative in yeast. Examples of vectors for expression in yeast (e.g., S. cerevisiae) include pYepSec1 (Baldari et al., EMBO J 6:229-234 (1987)), pMFa (Kurjan et al., Cell 30:933-943 (1982)), pJRY88 (Schultz et al., Gene 54:113-123 (1987)), and pYES2 (Invitrogen Corporation, San Diego, Calif.).
• The SNP-containing nucleic acid molecules can also be expressed in insect cells using, for example, baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., Sf 9 cells) include the pAc series (Smith et al., Mol Cell Biol 3:2156-2165 (1983)) and the pVL series (Lucklow et al., Virology 170:31-39 (1989)).
• In certain embodiments of the invention, the SNP-containing nucleic acid molecules described herein are expressed in mammalian cells using mammalian expression vectors. Examples of mammalian expression vectors include pCDM8 (B. Seed, Nature 329:840(1987)) and pMT2PC (Kaufman et al., EMBO J 6:187-195 (1987)).
• The invention also encompasses vectors in which the SNP-containing nucleic acid molecules described herein are cloned into the vector in reverse orientation, but operably linked to a regulatory sequence that permits transcription of antisense RNA. Thus, an antisense transcript can be produced to the SNP-containing nucleic acid sequences described herein, including both coding and non-coding regions. Expression of this antisense RNA is subject to each of the parameters described above in relation to expression of the sense RNA (regulatory sequences, constitutive or inducible expression, tissue-specific expression).
• The invention also relates to recombinant host cells containing the vectors described herein. Host cells therefore include, for example, prokaryotic cells, lower eukaryotic cells such as yeast, other eukaryotic cells such as insect cells, and higher eukaryotic cells such as mammalian cells.
• The recombinant host cells can be prepared by introducing the vector constructs described herein into the cells by techniques readily available to persons of ordinary skill in the art. These include, but are not limited to, calcium phosphate transfection, DEAE-dextran-mediated transfection, cationic lipid-mediated transfection, electroporation, transduction, infection, lipofection, and other techniques such as those described in Sambrook and Russell, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, N.Y. (2000).
• Host cells can contain more than one vector. Thus, different SNP-containing nucleotide sequences can be introduced in different vectors into the same cell. Similarly, the SNP-containing nucleic acid molecules can be introduced either alone or with other nucleic acid molecules that are not related to the SNP-containing nucleic acid molecules, such as those providing trans-acting factors for expression vectors. When more than one vector is introduced into a cell, the vectors can be introduced independently, co-introduced, or joined to the nucleic acid molecule vector.
• In the case of bacteriophage and viral vectors, these can be introduced into cells as packaged or encapsulated virus by standard procedures for infection and transduction. Viral vectors can be replication-competent or replication-defective. In the case in which viral replication is defective, replication can occur in host cells that provide functions that complement the defects.
• Vectors generally include selectable markers that enable the selection of the subpopulation of cells that contain the recombinant vector constructs. The marker can be inserted in the same vector that contains the SNP-containing nucleic acid molecules described herein or may be in a separate vector. Markers include, for example, tetracycline or ampicillin-resistance genes for prokaryotic host cells, and dihydrofolate reductase or neomycin resistance genes for eukaryotic host cells. However, any marker that provides selection for a phenotypic trait can be effective.
• While the mature variant proteins can be produced in bacteria, yeast, mammalian cells, and other cells under the control of the appropriate regulatory sequences, cell-free transcription and translation systems can also be used to produce these variant proteins using RNA derived from the DNA constructs described herein.
• Where secretion of the variant protein is desired, which is difficult to achieve with multi-transmembrane domain containing proteins such as G-protein-coupled receptors (GPCRs), appropriate secretion signals can be incorporated into the vector. The signal sequence can be endogenous to the peptides or heterologous to these peptides.
• Where the variant protein is not secreted into the medium, the protein can be isolated from the host cell by standard disruption procedures, including freeze/thaw, sonication, mechanical disruption, use of lysing agents, and the like. The variant protein can then be recovered and purified by well-known purification methods including, for example, ammonium sulfate precipitation, acid extraction, anion or cationic exchange chromatography, phosphocellulose chromatography, hydrophobic-interaction chromatography, affinity chromatography, hydroxylapatite chromatography, lectin chromatography, or high performance liquid chromatography.
• It is also understood that, depending upon the host cell in which recombinant production of the variant proteins described herein occurs, they can have various glycosylation patterns, or may be non-glycosylated, as when produced in bacteria. In addition, the variant proteins may include an initial modified methionine in some cases as a result of a host-mediated process.
• For further information regarding vectors and host cells, see Current Protocols in Molecular Biology, John Wiley & Sons, N.Y.
• Uses of Vectors and Host Cells, and Transgenic Animals
• Recombinant host cells that express the variant proteins described herein have a variety of uses. For example, the cells are useful for producing a variant protein that can be further purified into a preparation of desired amounts of the variant protein or fragments thereof. Thus, host cells containing expression vectors are useful for variant protein production.
• Host cells are also useful for conducting cell-based assays involving the variant protein or variant protein fragments, such as those described above as well as other formats known in the art. Thus, a recombinant host cell expressing a variant protein is useful for assaying compounds that stimulate or inhibit variant protein function. Such an ability of a compound to modulate variant protein function may not be apparent from assays of the compound on the native/wild-type protein, or from cell-free assays of the compound. Recombinant host cells are also useful for assaying functional alterations in the variant proteins as compared with a known function.
• Genetically-engineered host cells can be further used to produce non-human transgenic animals. A transgenic animal is preferably a non-human mammal, for example, a rodent, such as a rat or mouse, in which one or more of the cells of the animal include a transgene. A transgene is exogenous DNA containing a SNP of the present invention which is integrated into the genome of a cell from which a transgenic animal develops and which remains in the genome of the mature animal in one or more of its cell types or tissues. Such animals are useful for studying the function of a variant protein in vivo, and identifying and evaluating modulators of variant protein activity. Other examples of transgenic animals include, but are not limited to, non-human primates, sheep, dogs, cows, goats, chickens, and amphibians. Transgenic non-human mammals such as cows and goats can be used to produce variant proteins which can be secreted in the animal's milk and then recovered.
• A transgenic animal can be produced by introducing a SNP-containing nucleic acid molecule into the male pronuclei of a fertilized oocyte, e.g., by microinjection or retroviral infection, and allowing the oocyte to develop in a pseudopregnant female foster animal. Any nucleic acid molecules that contain one or more SNPs of the present invention can potentially be introduced as a transgene into the genome of a non-human animal.
• Any of the regulatory or other sequences useful in expression vectors can form part of the transgenic sequence. This includes intronic sequences and polyadenylation signals, if not already included. A tissue-specific regulatory sequence(s) can be operably linked to the transgene to direct expression of the variant protein in particular cells or tissues.
• Methods for generating transgenic animals via embryo manipulation and microinjection, particularly animals such as mice, have become conventional in the art and are described, for example, in U.S. Pat. Nos. 4,736,866 and 4,870,009, both by Leder et al.; U.S. Pat. No. 4,873,191 by Wagner et al., and in B. Hogan, Manipulating the Mouse Embryo, Cold Spring Harbor Laboratory Press, N.Y. (1986). Similar methods are used for production of other transgenic animals. A transgenic founder animal can be identified based upon the presence of the transgene in its genome and/or expression of transgenic mRNA in tissues or cells of the animals. A transgenic founder animal can then be used to breed additional animals carrying the transgene. Moreover, transgenic animals carrying a transgene can further be bred to other transgenic animals carrying other transgenes. A transgenic animal also includes a non-human animal in which the entire animal or tissues in the animal have been produced using the homologously recombinant host cells described herein.
• In another embodiment, transgenic non-human animals can be produced which contain selected systems that allow for regulated expression of the transgene. One example of such a system is the cre/loxP recombinase system of bacteriophage P1. Lakso et al., PNAS 89:6232-6236 (1992). Another example of a recombinase system is the FLP recombinase system of S. cerevisiae. O'Gorman et al., Science 251:1351-1355 (1991). If a cre/loxP recombinase system is used to regulate expression of the transgene, animals containing transgenes encoding both the Cre recombinase and a selected protein are generally needed. Such animals can be provided through the construction of “double” transgenic animals, e.g., by mating two transgenic animals, one containing a transgene encoding a selected variant protein and the other containing a transgene encoding a recombinase.
• Clones of the non-human transgenic animals described herein can also be produced according to the methods described, for example, in I. Wilmut et al., Nature 385:810-813 (1997) and PCT International Publication Nos. WO 97/07668 and WO 97/07669. In brief, a cell (e.g., a somatic cell) from the transgenic animal can be isolated and induced to exit the growth cycle and enter G_o phase. The quiescent cell can then be fused, e.g., through the use of electrical pulses, to an enucleated oocyte from an animal of the same species from which the quiescent cell is isolated. The reconstructed oocyte is then cultured such that it develops to morula or blastocyst and then transferred to pseudopregnant female foster animal. The offspring born of this female foster animal will be a clone of the animal from which the cell (e.g., a somatic cell) is isolated.
• Transgenic animals containing recombinant cells that express the variant proteins described herein are useful for conducting the assays described herein in an in vivo context. Accordingly, the various physiological factors that are present in vivo and that could influence ligand or substrate binding, variant protein activation, signal transduction, or other processes or interactions, may not be evident from in vitro cell-free or cell-based assays. Thus, non-human transgenic animals of the present invention may be used to assay in vivo variant protein function as well as the activities of a therapeutic agent or compound that modulates variant protein function/activity or expression. Such animals are also suitable for assessing the effects of null mutations (i.e., mutations that substantially or completely eliminate one or more variant protein functions).
• For further information regarding transgenic animals, see Houdebine, “Antibody manufacture in transgenic animals and comparisons with other systems,” Curr Opin Biotechnol 13(6):625-9 (December 2002); Petters et al., “Transgenic animals as models for human disease,” Transgenic Res 9(4-5):347-51, discussion 345-6 (2000); Wolf et al., “Use of transgenic animals in understanding molecular mechanisms of toxicity,” J Pharm Pharmacol 50(6):567-74 (June 1998); Echelard, “Recombinant protein production in transgenic animals,” Curr Opin Biotechnol 7(5):536-40 (October 1996); Houdebine, “Transgenic animal bioreactors,” Transgenic Res 9(4-5):305-20 (2000); Pirity et al., “Embryonic stem cells, creating transgenic animals,” Methods Cell Biol 57:279-93 (1998); and Robl et al., “Artificial chromosome vectors and expression of complex proteins in transgenic animals,” Theriogenology 59(1):107-13 (January 2003).
EXAMPLES
• The following examples are offered to illustrate, but not limit, the claimed invention.
Example 1 SNPs Associated with Statin Response in CARE, WOSCOPS, and PROVE IT-TIMI 22
• Overview
• In the study described here in Example 1, cohort and case-only study designs were used to identify SNPs associated with response to statin treatment. The entire cohort (individuals with and without incident CHD or CVD events) or cases only (only individuals with an incident CHD or CVD event) were analyzed in sample sets from the CARE, WOSCOPS, and PROVE IT. Specifically, analyses were carried out using these three sample sets to identify SNPs associated with a reduction in the risk of CHD or CVD (CVD includes CHD and stroke), the results of which are provided in Tables 4-7 and Tables 9-18 (Tables 9-18 provide additional genotyped SNPs as well as imputed SNPs).
• Tables 4-7 provide results of analyses of statin response for either CHD or CVD reduction, in three genetic models (dominant, recessive, and additive). Tables 4-7 provide SNPs that had a synergy index (odds ratio) with P value lower than 10⁻⁴ in a meta-analysis of CARE and WOSCOPS combined (Table 4-5) or in a meta-analysis of CARE, WOSCOPS, and PROVE-IT combined (Table 6-7), in any genetic model in either the CHD or CVD endpoint. Tables 4-5 provide meta-analyses of CARE and WOSCOPS combined, as well as logistic regression analysis of each sample set individually. Tables 6-7 provide meta-analyses of CARE, WOSCOPS, and PROVE-IT combined, as well as logistic regression analysis of each sample set individually.
• Tables 5 and 7 provide analyses of certain LD SNPs in CARE and WOSCOPS (Table 5) and in CARE, WOSCOPS, and PROVE-IT (Table 7). For some SNPs, case-only data was available for a first SNP while cohort data was available for a SNP in LD with the first SNP (LD SNP), which occurred when a working kPCR assay could not be made for the first SNP. For these SNPs, the data for case-only analysis and the available data for the cohort is reported. The meta-analysis was performed with the cohort data when available. These SNPs are listed in Tables 5 and 7, with the two SNPs in LD listed one below the other, and the degree of LD (r²) between each of these pairs of SNPs is provided in Table 8.
• CARE, WOSCOPS, and PROVE IT-TIMI 22 Sample Sets
• The CARE (“Cholesterol and Recurrent Events”) and WOSCOPS (“West of Scotland Coronary Prevention Study”) studies were prospective trials that assessed the effect of pravastatin (40 mg/day) on the prevention of MI and CHD. CARE was a secondary prevention trial and WOSCOPS was a primary prevention trial. The PROVE IT-TIMI 22 (“Pravastatin or Atorvastatin Evaluation and Infection Therapy: Thrombolysis in Myocardial Infarction 22”; which is interchangeably referred to herein as “PROVE-IT”) trial evaluated the effectiveness of intensive therapy with high-dose atorvastatin (80 mg/day) versus moderate therapy with standard-dose pravastatin (40 mg/day, which was the dose used in the CARE and WOSCOPS trials) in preventing death or cardiovascular events in patients with a recent acute coronary syndrome.
• These trials and the sample sets from these trials (such as the inclusion criteria for participants) are described in the following references. Those portions of each of the following references that pertain to the CARE, WOSCOPS, and PROVE-IT trials and sample sets are hereby incorporated by reference. CARE is described in Sacks et al., “Cholesterol and Recurrent Events Trial Investigators. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels”, N Engl J Med 1996; 335:1001-9, and WOSCOPS is described in Shepherd et al., “West of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia”, N Engl J Med 1995; 333:1301-7. PROVE-IT is described in Iakoubova et al., Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study”, J Am Coll Cardiol. 2008 Jan. 29; 51(4):449-55 and Cannon et al., “Intensive versus moderate lipid lowering with statins after acute coronary syndromes”, N Engl J Med 2004; 350:1495-504.
• Endpoints
• The endpoint definitions used in these analyses of CARE, WOSCOPS, and PROVE-IT (the results of which are provided in Tables 4-7) were as follows. The CHD endpoint was defined in the analyses herein of CARE as a composite endpoint of fatal CHD, definite non-fatal MI, or revascularization, and was defined in the analyses herein of WOSCOPS as a composite endpoint of death from CHD, nonfatal MI, or revascularization. In both the CARE and WOSCOPS analyses herein, the CVD endpoint was defined as a composite endpoint of CHD or stroke. The analyses herein of PROVE-IT analyzed the primary endpoint of PROVE-IT, which was a composite endpoint of revascularization (if performed at least 30 days after randomization), unstable angina requiring hospitalization, MI, all causes of death, or stroke. Thus, there was only one endpoint for PROVE-IT (the composite primary endpoint of the original PROVE-IT study, which includes some stroke cases), and this endpoint was used in the meta-analysis for both CHD and CVD provided in Tables 6-7. With respect to stroke, in the analyses herein of CARE and PROVE-IT, stroke was defined as stroke or transient ischemic attack (TIA), and in the analyses herein of WOSCOPS, stroke was defined as fatal or non-fatal stroke. Revascularization, which can include percutaneous transluminal coronary angioplasty (PTCA), stent placement, and coronary artery bypass graft (CABG), are medical interventions that indicate the presence of CHD.
• Study Designs
• Cohort and case-only study designs were used to identify SNPs associated with response to statin treatment. The entire cohort (individuals with and without incident CHD or CVD events; identified as “cohort” in the “Source” column of Tables 4-7) or only individuals with an incident CHD or CVD event (identified as “CaseOnly” in the “Source” column of Tables 4-7) were analyzed in sample sets from the CARE, WOSCOPS, and PROVE-IT trials to test whether the reduction of CHD/CVD events by statin therapy (for CARE and WOSCOPS studies), or by high dose atorvastatin therapy (for the PROVE IT study), differed according to genotype (a treatment by SNP interaction) for each SNP evaluated in the study.
• For each SNP, a logistic regression model having treatment status as the dependent variable and SNP as the independent predictor variable was performed, with terms for age, sex and race included in the model as covariates. The anti-log of the regression coefficient corresponding to the SNP is an estimate of the synergy index (SI) (Davis et al., “Imputing gene-treatment interactions when the genotype distribution is unknown using case-only and putative placebo analyses—a new method for the Genetics of Hypertension Associated Treatment (GenHAT) study”, Statistics in Medicine 23: (2004), pages 2413-2427). The SI is a ratio of odds ratios: for example in the CARE and WOSCOPS studies, the SI represents the factor by which the odds-ratio of statin treatment, compared with placebo, among major homozygous individuals is multiplied by in order to obtain the odds-ratio of treatment vs. placebo among heterozygous individuals; and multiplied by a second time to obtain the odds-ratio of treatment vs. placebo in minor homozygous individuals. The case-only study design results in a valid estimate of the SI under the assumption that genotype and treatment are independent in the population. In a randomized clinical trial, genotype and treatment are independent by design. The p-value for the regression coefficient corresponding to the SNP results from a test of the null hypothesis that the regression coefficient is equal to zero (SI is equal to one) and thus small p-values indicate the SI is unlikely equal to one and that the effect of treatment likely differs by genotype.
• The logistic regression models were performed separately for each of CARE, WOSCOPS, and PROVE-IT in order to obtain study-specific results. A meta-analysis was then used to estimate the combined evidence for interaction when considering either the CARE and WOSCOPS studies (Tables 4-5), or all three studies (CARE, WOSCOPS, and PROVE-IT) (Tables 6-7). The meta-analysis used the inverse variance method (Rothman et al., 1998; Modern Epidemiology, 2nd edition, Lippincott Williams & Wilkins, Philadelphia, Pa., pages 660-661) to calculate the combined SI using a weighted average of the effects of the individual studies with weights equal to the inverse variance from each study.
• The logistic regression and meta-analyses were performed using PLINK version 1.07 (Purcell et al. (2007), “PLINK: A tool set for whole-genome association and population-based linkage analyses”, Am. J. Hum. Genet. 81, 559-575).
• Regarding case-only study designs specifically, further information about these study designs is provided in Piegorsch et al., “Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies”, Statistics in Medicine 13 (1994) (pages 153-162); Khoury et al., “Nontraditional Epidemiologic Approaches in the Analysis of Gene-Environment Interaction: Case-Control Studies with No Controls!”, American Journal of Epidemiology 144:3 (1996) (pages 207-213); Pierce et al., “Case-only genome-wide interaction study of disease risk, prognosis and treatment”, Genet Epidemiol. 2010 January; 34(1):7-15; Begg et al., “Statistical analysis of molecular epidemiology studies employing case-series”, Cancer Epidemiology Biomarkers and Prevention 3 (1994) pp 173-175; Yang et al., “Sample Size Requirements in Case-Only Designs to Detect Gene-Environment Interaction”, American Journal of Epidemiology 146:9 (1997) pp 713-720; Albert et al., “Limitations of the Case-only Design for Identifying Gene-Environment Interactions”, American Journal of Epidemiology 154:8 (2001) pp 687-693; and Wang et al., “Population Stratification Bias in the Case-Only Study for Gene-Environment Interactions”, American Journal of Epidemiology 168:2 (2008) pp 197-201, each of which is incorporated herein by reference in its entirety. Further information about genome-wide association studies is provided in Wellcome Trust Case Control Consortium, “Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls”, Nature. 2007 Jun. 7; 447(7145):661-78 and Ikram et al., “Genomewide association studies of stroke”, N Engl J Med. 2009 Apr. 23; 360(17):1718-28.
• Identification of Additional Statin Response-Associated SNPs by Imputation and Genotyping
• Additional genotyped and imputed SNPs were identified as being associated with statin response in the CARE, WOSCOPS, and PROVE-IT sample sets, and these additional SNPs are provided in Tables 9-18. The association of certain of these SNPs with statin response was identified by genotyping, whereas the association of certain other SNPs with statin response was identified by imputation. Imputation involves imputing the allele/genotype present at a SNP for each individual in the sample set (CARE, WOSCOPS, and PROVE-IT) rather than directly genotyping the SNP in a sample from the individual. Thus, Tables 9-18 include SNPs identified by imputation as well as SNPs identified by genotyping, and the column labeled “Source” in Tables 9-18 indicates whether each SNP was genotyped or imputed (all of the SNPs provided in Tables 4-7 were identified by genotyping).
• Specifically, Tables 9-18 provide SNPs for which the p-value for a random effect was lower than 10⁻⁴ for either the meta-analysis of CARE and WOSCOPS combined or the meta-analysis of CARE, WOSCOPS, and PROVE-IT combined, for either the CHD or CVD endpoint, and for any genetic model (dominant, recessive, additive, or genotypic). Association interaction between statin response and either the CHD or CVD phenotype was performed. SNPs were either imputed or genotyped.
• Imputation was carried out using the BEAGLE genetic analysis program to analyze genotyping data from the HapMap project (The International HapMap Consortium, NCBI, NLM, NIH). Imputation and the BEAGLE program (including the modeling algorithm that BEAGLE utilizes) are described in the following references: Browning, “Missing data imputation and haplotype phase inference for genome-wide association studies”, Hum Genet (2008) 124:439-450 (which reviews imputation and BEAGLE); B L Browning and S R Browning (2009) “A unified approach to genotype imputation and haplotype phase inference for large data sets of trios and unrelated individuals”. Am J Hum Genet 84:210-223 (which describes BEAGLE's methods for imputing ungenotyped markers and phasing parent-offspring trios); S R Browning and B L Browning (2007) “Rapid and accurate haplotype phasing and missing data inference for whole genome association studies using localized haplotype clustering”. Am J Hum Genet 81:1084-1097 (which describes BEAGLE's methods for inferring haplotype phase or sporadic missing data in unrelated individuals); B L Browning and S R Browning (2007) “Efficient multilocus association mapping for whole genome association studies using localized haplotype clustering”. Genet Epidemiol 31:365-375 (which describes BEAGLE's methods for association testing); S R Browning (2006) “Multilocus association mapping using variable-length Markov chains”. Am J Hum Genet 78:903-13 (which describes BEAGLE's haplotype frequency model); and B L Browning and S R Browning (2008) “Haplotypic analysis of Wellcome Trust Case Control Consortium data”. Human Genetics 123:273-280 (which describes an example in which BEAGLE was used to analyze a large genome-wide association study). Each of these references related to imputation and the BEAGLE program is incorporated herein by reference in its entirety.
Example 2 Polymorphism rs11556924 in the ZC3HC1 Gene is Associated with Differential CHD Risk Reduction by Statin Therapy in CARE and WOSCOPS
• A case-only study design was used to test whether the reduction of CHD events by statin therapy (for CARE and WOSCOPS studies) differed according to genotype (a treatment by SNP interaction) for each SNP evaluated in the study.
• Herein in Example 2, SNPs previously reported to be associated with coronary artery disease (Schunkert et al., “Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease”, Nat Genet. 2011 Mar. 6; and Peden et al., “A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease”, Nat Genet. 2011 Mar. 6) were analyzed using the same methodology as described above in Example 1 in order to determine whether any of these SNP are associated with differential CHD risk reduction by statin therapy in a genome wide association study conducted among cases of CARE and WOSCOPS.
• It was determined from this analysis that SNP rs11556924 (hCV31283062) in the ZC3HC1 gene is associated with differential reduction of CHD risk by pravastatin therapy in both CARE and WOSCOPS (see Table 19).
Example 3 SNPs Around Chromosomal Locations 9p21 and 12p13 (NINJ2 and B4GALNT3 Gene Region) Associated with Stroke Statin Response and/or Stroke Risk
• Example 3 relates to genetic polymorphisms that are associated with stroke risk and/or stroke statin response (reduction of stroke risk by statin treatment) (Tables 20-21) and CHD statin response (Table 22).
• Table 20 provides SNPs associated with stroke risk and/or stroke statin response in the CARE sample set. For example, SNPs rs10757278 and rs1333049 at chromosomal location 9p21 were associated with a reduction of stroke events by statin treatment in CARE, particularly for heterozygotes (see Table 20). Furthermore, SNPs rs12425791 and rs11833579 at chromosomal location 12p13 near the NINJ2 gene were associated with stroke risk in the placebo arm of CARE (see Table 20). SNPs rs12425791 and rs11833579 were also associated with stroke statin response in that the homozygous and heterozygous carriers of either of these SNPs (i.e., carriers of the ‘A’ allele for either rs12425791 or rs11833579) had a greater reduction in stroke events with statin treatment compared with noncarriers (see Table 20). Consistent with the CARE trial, the stroke endpoint in the analysis for which the results are provided in Tables 20-21 included stroke as well as transient ischemic attack (TIA).
• Fine-mapping at the chromosome 12p13 locus was carried out by selecting 77 tagging SNPs from a 400 kb region of the chromosome 12p13 locus which covered the NINJ2 gene and other genes, genotyping these 77 SNPs, and further imputing the genotypes of approximately 250 additional SNPs in this region, for individuals in the CARE study. Analyzing these fine-mapping SNPs for association with stroke risk in the placebo arm of CARE and for stroke statin response in CARE identified SNP rs873134 in the B4GALNT3 gene in the chromosome 12p13 region near NINJ2 (see Table 21).
• Table 22 provides results of an analysis of CHD statin response in CARE. Table 22 shows that SNP rs873134 is associated with response to statin treatment for reducing the risk of CHD (as well as for reducing the risk of stroke, as shown in Table 21). Specifically, Table 22 shows that SNP rs873134 is associated with a reduced occurrence of recurrent MI in individuals in the CARE study who were treated with statins. Thus, SNP rs873134 is an example of a SNP that is associated with statin response for reducing risk for both stroke and CHD. In the analysis for which the results are provided in Table 22, the endpoint was recurrent MI, and the analysis was adjusted for age, gender, hypertension, diabetes, base LDL and HDL, and whether an individual was a current smoker.
Example 4 LD SNPs Associated with Statin Response and CVD
• Another investigation was conducted to identify additional SNPs that are in high linkage disequilibrium (LD) with certain “interrogated SNPs” that have been found to be associated with response to statin treatment (particularly for reducing the risk of CVD, especially CHD such as MI). The “interrogated SNPs” were those SNPs provided in Tables 4-22 (the interrogated SNPs are shown in columns 1-2 of Table 3, which indicates the hCV and rs identification numbers of each interrogated SNP), and the LD SNPs which were identified as being in high LD are provided in Table 3 (in the columns labeled “LD SNP”, which indicate the hCV and rs identification numbers of each LD SNP).
• Specifically, Table 3 provides LD SNPs from the HapMap database (NCBI, NLM, NIH) that have linkage disequilibrium r² values of at least 0.9 (the threshold r² value, which may also be designated as r_T ²) with an interrogated SNP. Each of these LD SNPs from the HapMap database is within 500 kb of its respective interrogated SNP, and the r² values are calculated based on genotypes of HapMap Caucasian subjects. If an interrogated SNP is not in the HapMap database, then there will not be any LD SNPs listed in Table 3 for that interrogated SNP.
• As an example in Table 3, the interrogated SNP rs688358 (hCV1056543) was calculated to be in LD with rs675163 (hCV1056544) at an r² value of 1 (which is above the threshold r² value of 0.9), thus establishing the latter SNP as a marker associated with statin response as well.
• In this example, the threshold r² value was set at 0.9. However, the threshold r² value can be set at other values such that one of ordinary skill in the art would consider that any two SNPs having an r² value greater than or equal to the threshold r² value would be in sufficient LD with each other such that either SNP is useful for the same utilities, such as determining an individual's response to statin treatment. For example, in various embodiments, the threshold r² value used to classify SNPs as being in sufficient LD with an interrogated SNP (such that these LD SNPs can be used for the same utilities as the interrogated SNP, for example) can be set at, for example, 0.7, 0.75, 0.8, 0.85, 0.95, 0.96, 0.97, 0.98, 0.99, 1, etc. (or any other threshold r² value in-between these values). Threshold r² values may be utilized with or without considering power or other calculations.
• Sequences, SNP information, and associated gene/transcript/protein information for each of the LD SNPs listed in Table 3 is provided in Tables 1-2. Thus, for any LD SNP listed in Table 3, sequence and allele information (or other information) can be found by searching Tables 1-2 using the hCV or rs identification number of the LD SNP of interest.
• All publications and patents cited in this specification are herein incorporated by reference in their entirety. Modifications and variations of the described compositions, methods and systems of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific preferred embodiments and certain working examples, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. Indeed, various modifications of the above-described modes for carrying out the invention that are obvious to those skilled in the field of molecular biology, genetics and related fields are intended to be within the scope of the following claims.

• TABLE 3
  Interrogated SNP	Interrogated
  (hCV #)	SNP (rs #)	LD SNP (hCV #)	LD SNP (rs #)	Threshold r2	r2

  hCV1056543	rs688358	hCV1056544	rs675163	0.9	1
  hCV1056543	rs688358	hCV32014853	rs11221097	0.9	1
  hCV1056543	rs688358	hCV767324	rs687047	0.9	1
  hCV1056544	rs675163	hCV1056543	rs688358	0.9	1
  hCV1056544	rs675163	hCV32014843	rs11221075	0.9	1
  hCV1056544	rs675163	hCV32014853	rs11221097	0.9	1
  hCV1056544	rs675163	hCV767324	rs687047	0.9	1
  hCV11435810	rs7808536	hCV11435811	rs2057903	0.9	1
  hCV11435810	rs7808536	hCV16010888	rs2402516	0.9	0.9445
  hCV11435810	rs7808536	hCV16151622	rs2896295	0.9	1
  hCV11435810	rs7808536	hCV2580015	rs6973461	0.9	1
  hCV11435810	rs7808536	hCV26499740	rs1344081	0.9	0.9396
  hCV11435810	rs7808536	hCV29630277	rs7799541	0.9	1
  hCV11435810	rs7808536	hCV29720798	rs10228725	0.9	1
  hCV11435810	rs7808536	hCV29738883	rs10237648	0.9	1
  hCV11435810	rs7808536	hCV29865261	rs10226287	0.9	1
  hCV11435810	rs7808536	hCV30243451	rs10270624	0.9	1
  hCV11435810	rs7808536	hCV30441808	rs10487413	0.9	0.9485
  hCV11435810	rs7808536	hCV31281599	rs13438543	0.9	1
  hCV11544885	rs1536506	hCV16243612	rs2478888	0.9	0.963
  hCV11544885	rs1536506	hCV16243614	rs2478885	0.9	0.9587
  hCV11544885	rs1536506	hCV16252195	rs2504709	0.9	1
  hCV11544885	rs1536506	hCV16252196	rs2504710	0.9	1
  hCV11544885	rs1536506	hCV2005097	rs2478886	0.9	0.9622
  hCV11544885	rs1536506	hCV2005121	rs2504708	0.9	1
  hCV11544885	rs1536506	hCV2005126	rs1536507	0.9	1
  hCV11544885	rs1536506	hCV2005128	rs2504705	0.9	1
  hCV11544885	rs1536506	hCV2005129	rs2478872	0.9	1
  hCV11544885	rs1536506	hCV2005135	rs2504702	0.9	0.9615
  hCV11544885	rs1536506	hCV2005136	rs1998950	0.9	0.9273
  hCV11544885	rs1536506	hCV27016744	rs2478874	0.9	0.9625
  hCV11544885	rs1536506	hCV8768604	rs1327283	0.9	0.9447
  hCV11544885	rs1536506	hCV8768614	rs1342619	0.9	0.9637
  hCV11544885	rs1536506	hCV992360	rs748514	0.9	0.9269
  hCV1166098	rs4660234	hCV1166103	rs12407412	0.9	1
  hCV1166098	rs4660234	hCV1166105	rs11576627	0.9	1
  hCV1166098	rs4660234	hCV30202184	rs6685920	0.9	1
  hCV1166103	rs12407412	hCV1166098	rs4660234	0.9	1
  hCV1166103	rs12407412	hCV1166105	rs11576627	0.9	1
  hCV1166103	rs12407412	hCV30202184	rs6685920	0.9	1
  hCV1166105	rs11576627	hCV1166098	rs4660234	0.9	1
  hCV1166105	rs11576627	hCV1166103	rs12407412	0.9	1
  hCV1166105	rs11576627	hCV30202184	rs6685920	0.9	1
  hCV11675665	rs2574	hCV11226242	rs2280210	0.9	1
  hCV11675665	rs2574	hCV11675666	rs2575	0.9	0.9636
  hCV11675665	rs2574	hCV245252	rs9835936	0.9	0.9636
  hCV11675665	rs2574	hCV474806	rs11927308	0.9	1
  hCV11686367	rs7955901	hCV11686374	rs7957932	0.9	0.9161
  hCV11686367	rs7955901	hCV171102	rs7313973	0.9	0.9568
  hCV11686367	rs7955901	hCV240133	rs4760895	0.9	0.9644
  hCV11686367	rs7955901	hCV240134	rs7138300	0.9	0.9432
  hCV11686367	rs7955901	hCV2745807	rs2063591	0.9	0.9303
  hCV11686367	rs7955901	hCV2745815	rs1512991	0.9	1
  hCV11686367	rs7955901	hCV2745822	rs1913201	0.9	0.9432
  hCV11686367	rs7955901	hCV2745828	rs10879240	0.9	0.9274
  hCV11686367	rs7955901	hCV27952502	rs4760894	0.9	0.9644
  hCV11686367	rs7955901	hCV27952503	rs4760785	0.9	0.9644
  hCV11686367	rs7955901	hCV29120310	rs7298255	0.9	0.9442
  hCV11686367	rs7955901	hCV31190748	rs7959965	0.9	0.9442
  hCV11686367	rs7955901	hCV31190777	rs10784891	0.9	1
  hCV11686367	rs7955901	hDV72015086	rs7956274	0.9	1
  hCV11819777	rs13172910	hCV26478734	rs11956952	0.9	1
  hCV11819777	rs13172910	hCV31237558	rs6898857	0.9	1
  hCV11819780	rs12153185	hCV11819782	rs12719415	0.9	1
  hCV11819780	rs12153185	hCV2575318	rs7711358	0.9	0.9232
  hCV11819780	rs12153185	hCV2575336	rs2418541	0.9	0.9232
  hCV11819780	rs12153185	hCV2575340	rs11242020	0.9	0.9232
  hCV11819780	rs12153185	hCV26478744	rs2016194	0.9	1
  hCV11819780	rs12153185	hCV26478745	rs2108426	0.9	1
  hCV11819780	rs12153185	hCV26478747	rs2190598	0.9	1
  hCV11819780	rs12153185	hCV26478763	rs2418542	0.9	0.9232
  hCV11819780	rs12153185	hCV27996154	rs4836502	0.9	1
  hCV11819780	rs12153185	hCV2961244	rs2418548	0.9	1
  hCV11819780	rs12153185	hCV2961250	rs4836507	0.9	1
  hCV11819780	rs12153185	hCV2961252	rs10067895	0.9	1
  hCV11819780	rs12153185	hCV2961253	rs2190600	0.9	1
  hCV11819780	rs12153185	hCV2961259	rs11242023	0.9	0.9571
  hCV11819780	rs12153185	hCV2961260	rs11242022	0.9	0.9785
  hCV11819780	rs12153185	hCV2961261	rs11242021	0.9	1
  hCV11819780	rs12153185	hCV2961267	rs1476714	0.9	1
  hCV11819780	rs12153185	hCV2961268	rs2108425	0.9	1
  hCV11819780	rs12153185	hCV2961269	rs2158958	0.9	1
  hCV11819780	rs12153185	hCV2961270	rs9327555	0.9	1
  hCV11819780	rs12153185	hCV2961278	rs7446891	0.9	1
  hCV11819780	rs12153185	hCV2961280	rs10520072	0.9	1
  hCV11819780	rs12153185	hCV2961282	rs917295	0.9	1
  hCV11819780	rs12153185	hCV2961284	rs10054055	0.9	0.9573
  hCV11819780	rs12153185	hCV2961296	rs10051148	0.9	0.9608
  hCV11819780	rs12153185	hCV2961297	rs2158961	0.9	0.9616
  hCV11819780	rs12153185	hCV2961306	rs264129	0.9	0.9358
  hCV11819780	rs12153185	hCV30621656	rs10478919	0.9	0.9232
  hCV11819780	rs12153185	hCV31237567	rs11749272	0.9	0.9232
  hCV11819780	rs12153185	hCV346713	rs1990023	0.9	0.9358
  hCV11819780	rs12153185	hCV546489	rs264122	0.9	0.9573
  hCV11819780	rs12153185	hCV8932829	rs1116596	0.9	0.9232
  hCV11819782	rs12719415	hCV11819780	rs12153185	0.9	1
  hCV11819782	rs12719415	hCV2575318	rs7711358	0.9	0.927
  hCV11819782	rs12719415	hCV2575336	rs2418541	0.9	0.927
  hCV11819782	rs12719415	hCV2575340	rs11242020	0.9	0.927
  hCV11819782	rs12719415	hCV26478744	rs2016194	0.9	0.9198
  hCV11819782	rs12719415	hCV26478745	rs2108426	0.9	0.9135
  hCV11819782	rs12719415	hCV26478747	rs2190598	0.9	1
  hCV11819782	rs12719415	hCV26478763	rs2418542	0.9	0.927
  hCV11819782	rs12719415	hCV27996154	rs4836502	0.9	1
  hCV11819782	rs12719415	hCV2961244	rs2418548	0.9	1
  hCV11819782	rs12719415	hCV2961250	rs4836507	0.9	1
  hCV11819782	rs12719415	hCV2961252	rs10067895	0.9	1
  hCV11819782	rs12719415	hCV2961253	rs2190600	0.9	1
  hCV11819782	rs12719415	hCV2961259	rs11242023	0.9	0.9621
  hCV11819782	rs12719415	hCV2961260	rs11242022	0.9	1
  hCV11819782	rs12719415	hCV2961261	rs11242021	0.9	1
  hCV11819782	rs12719415	hCV2961267	rs1476714	0.9	1
  hCV11819782	rs12719415	hCV2961268	rs2108425	0.9	1
  hCV11819782	rs12719415	hCV2961269	rs2158958	0.9	1
  hCV11819782	rs12719415	hCV2961270	rs9327555	0.9	1
  hCV11819782	rs12719415	hCV2961278	rs7446891	0.9	1
  hCV11819782	rs12719415	hCV2961280	rs10520072	0.9	1
  hCV11819782	rs12719415	hCV2961282	rs917295	0.9	1
  hCV11819782	rs12719415	hCV2961284	rs10054055	0.9	0.9616
  hCV11819782	rs12719415	hCV2961296	rs10051148	0.9	0.9623
  hCV11819782	rs12719415	hCV2961297	rs2158961	0.9	0.9634
  hCV11819782	rs12719415	hCV2961306	rs264129	0.9	0.9232
  hCV11819782	rs12719415	hCV30621656	rs10478919	0.9	0.927
  hCV11819782	rs12719415	hCV31237567	rs11749272	0.9	0.927
  hCV11819782	rs12719415	hCV346713	rs1990023	0.9	0.9232
  hCV11819782	rs12719415	hCV546489	rs264122	0.9	0.9616
  hCV11819782	rs12719415	hCV8932829	rs1116596	0.9	0.927
  hCV1311177	rs1868616	hCV26853900	rs17718789	0.9	0.9408
  hCV1319507	rs16938626	hCV1319514	rs2383903	0.9	1
  hCV1319507	rs16938626	hCV1319518	rs13265054	0.9	0.9055
  hCV1319514	rs2383903	hCV1319507	rs16938626	0.9	1
  hCV1319516	rs12678600	hCV1319518	rs13265054	0.9	1
  hCV1319516	rs12678600	hCV31080080	rs12679254	0.9	1
  hCV1319518	rs13265054	hCV1319507	rs16938626	0.9	0.9055
  hCV1319518	rs13265054	hCV1319516	rs12678600	0.9	1
  hCV1319518	rs13265054	hCV31080080	rs12679254	0.9	1
  hCV1329037	rs9295154	hCV29673016	rs9458285	0.9	1
  hCV1329037	rs9295154	hCV30231903	rs9458302	0.9	1
  hCV1329037	rs9295154	hCV31883369	rs9458310	0.9	0.9236
  hCV1558085	rs11656608	hCV11625525	rs7222186	0.9	1
  hCV1558085	rs11656608	hCV11625528	rs9911847	0.9	0.9144
  hCV1558085	rs11656608	hCV11625529	rs9911867	0.9	0.9079
  hCV1558085	rs11656608	hCV1558080	rs9914580	0.9	1
  hCV1558085	rs11656608	hCV1558083	rs9916432	0.9	0.9144
  hCV1558085	rs11656608	hCV1558084	rs880718	0.9	0.9137
  hCV1558085	rs11656608	hCV29293441	rs8066502	0.9	1
  hCV1558085	rs11656608	hCV29979212	rs8068714	0.9	1
  hCV1558085	rs11656608	hCV29997278	rs9906737	0.9	1
  hCV1558085	rs11656608	hCV7459667	rs937890	0.9	0.9144
  hCV16126066	rs2110564	hCV2676440	rs6722640	0.9	1
  hCV16126066	rs2110564	hCV27872026	rs4851531	0.9	0.9638
  hCV16126066	rs2110564	hCV349805	rs4851529	0.9	0.9329
  hCV16126066	rs2110564	hCV8905894	rs974950	0.9	1
  hCV1631038	rs9487284	hCV11632712	rs9481031	0.9	0.9098
  hCV1631038	rs9487284	hCV11638660	rs6917496	0.9	0.9098
  hCV1631038	rs9487284	hCV11638661	rs6937788	0.9	0.9098
  hCV1631038	rs9487284	hCV1631013	rs17614034	0.9	0.9098
  hCV1631038	rs9487284	hCV1631015	rs9481026	0.9	0.9098
  hCV1631038	rs9487284	hCV1631022	rs9481029	0.9	0.9098
  hCV1631038	rs9487284	hCV1631034	rs7776217	0.9	0.9098
  hCV1631038	rs9487284	hCV1631035	rs7758270	0.9	0.9098
  hCV1631038	rs9487284	hCV1631067	rs9481038	0.9	0.9098
  hCV1631038	rs9487284	hCV8703496	rs1564077	0.9	0.9098
  hCV1787026	rs475420	hCV1787039	rs538521	0.9	1
  hCV1787026	rs475420	hCV1787042	rs657929	0.9	0.9081
  hCV1973764	rs1866386	hCV1973774	rs1483301	0.9	0.9505
  hCV1973764	rs1866386	hCV1973785	rs2930049	0.9	0.9732
  hCV2053088	rs1155875	hCV2053097	rs4259369	0.9	0.961
  hCV2053088	rs1155875	hCV2053101	rs7795792	0.9	0.9608
  hCV2053088	rs1155875	hCV2053104	rs2163339	0.9	0.961
  hCV2053088	rs1155875	hCV2053105	rs2195672	0.9	0.9604
  hCV2053088	rs1155875	hCV30565702	rs10237019	0.9	0.963
  hCV2053097	rs4259369	hCV2053088	rs1155875	0.9	0.961
  hCV2053097	rs4259369	hCV2053101	rs7795792	0.9	1
  hCV2053097	rs4259369	hCV2053104	rs2163339	0.9	1
  hCV2053097	rs4259369	hCV2053105	rs2195672	0.9	1
  hCV2053097	rs4259369	hCV30565702	rs10237019	0.9	1
  hCV2053101	rs7795792	hCV2053088	rs1155875	0.9	0.9608
  hCV2053101	rs7795792	hCV2053097	rs4259369	0.9	1
  hCV2053101	rs7795792	hCV2053104	rs2163339	0.9	1
  hCV2053101	rs7795792	hCV2053105	rs2195672	0.9	1
  hCV2053101	rs7795792	hCV30565702	rs10237019	0.9	1
  hCV2209126	rs208026	hCV11706604	rs208035	0.9	0.9176
  hCV2209126	rs208026	hCV11706608	rs373886	0.9	0.9466
  hCV2209126	rs208026	hCV16233239	rs2237852	0.9	0.9176
  hCV2209126	rs208026	hCV16233240	rs2237853	0.9	0.9176
  hCV2209126	rs208026	hCV2442004	rs208030	0.9	0.9176
  hCV2209194	rs399485	hCV2209191	rs447024	0.9	0.9164
  hCV2209194	rs399485	hCV2209197	rs7508	0.9	0.9573
  hCV2209197	rs7508	hCV2209194	rs399485	0.9	0.9573
  hCV240133	rs4760895	hCV11686367	rs7955901	0.9	0.9644
  hCV240133	rs4760895	hCV171102	rs7313973	0.9	0.9603
  hCV240133	rs4760895	hCV240134	rs7138300	0.9	1
  hCV240133	rs4760895	hCV2745815	rs1512991	0.9	0.9668
  hCV240133	rs4760895	hCV2745822	rs1913201	0.9	1
  hCV240133	rs4760895	hCV2745828	rs10879240	0.9	0.9664
  hCV240133	rs4760895	hCV27952502	rs4760894	0.9	1
  hCV240133	rs4760895	hCV27952503	rs4760785	0.9	1
  hCV240133	rs4760895	hCV29120310	rs7298255	0.9	0.9644
  hCV240133	rs4760895	hCV31190748	rs7959965	0.9	0.9644
  hCV240133	rs4760895	hCV31190777	rs10784891	0.9	0.962
  hCV240133	rs4760895	hDV72015086	rs7956274	0.9	0.9649
  hCV240134	rs7138300	hCV11686367	rs7955901	0.9	0.9432
  hCV240134	rs7138300	hCV171102	rs7313973	0.9	0.9568
  hCV240134	rs7138300	hCV240133	rs4760895	0.9	1
  hCV240134	rs7138300	hCV2745815	rs1512991	0.9	0.9644
  hCV240134	rs7138300	hCV2745822	rs1913201	0.9	1
  hCV240134	rs7138300	hCV2745828	rs10879240	0.9	0.9639
  hCV240134	rs7138300	hCV27952502	rs4760894	0.9	1
  hCV240134	rs7138300	hCV27952503	rs4760785	0.9	1
  hCV240134	rs7138300	hCV31190777	rs10784891	0.9	0.9588
  hCV240134	rs7138300	hDV72015086	rs7956274	0.9	0.9622
  hCV2442103	rs373983	hCV2209192	rs383499	0.9	0.9297
  hCV2529198	rs742827	hCV2529202	rs6040667	0.9	0.9624
  hCV2529198	rs742827	hCV2529211	rs17189710	0.9	0.9596
  hCV2529198	rs742827	hCV2529224	rs2327412	0.9	0.9596
  hCV2529198	rs742827	hCV2529230	rs4444612	0.9	0.9596
  hCV2529198	rs742827	hCV2529231	rs4315598	0.9	0.9596
  hCV2529198	rs742827	hCV2529239	rs6040638	0.9	0.9596
  hCV2529198	rs742827	hCV2529241	rs6134243	0.9	0.9624
  hCV2529198	rs742827	hCV2529246	rs6040619	0.9	0.9596
  hCV2529198	rs742827	hCV27367681	rs2876227	0.9	1
  hCV2529198	rs742827	hCV27367708	rs1009748	0.9	0.9596
  hCV2529198	rs742827	hCV29840965	rs6040644	0.9	0.9596
  hCV2529198	rs742827	hCV30057061	rs6033138	0.9	0.9624
  hCV2529198	rs742827	hCV30093270	rs6040625	0.9	0.9624
  hCV2529198	rs742827	hCV30129243	rs6040636	0.9	0.9624
  hCV2529198	rs742827	hCV30218977	rs6040633	0.9	0.9624
  hCV2529198	rs742827	hCV30417550	rs6040634	0.9	0.9624
  hCV2529198	rs742827	hCV30453433	rs6131208	0.9	0.9167
  hCV2529198	rs742827	hCV32274419	rs13038146	0.9	0.9624
  hCV2529198	rs742827	hCV330228	rs6040668	0.9	0.9624
  hCV2529202	rs6040667	hCV2529198	rs742827	0.9	0.9624
  hCV2529202	rs6040667	hCV2529211	rs17189710	0.9	1
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  hCV2529202	rs6040667	hCV27367681	rs2876227	0.9	0.9649
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  hCV2529202	rs6040667	hCV30453433	rs6131208	0.9	0.9585
  hCV2529202	rs6040667	hCV30615489	rs6040630	0.9	0.9294
  hCV2529202	rs6040667	hCV32274419	rs13038146	0.9	1
  hCV2529202	rs6040667	hCV330228	rs6040668	0.9	1
  hCV2529211	rs17189710	hCV2529198	rs742827	0.9	0.9596
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  hCV2529211	rs17189710	hCV2529241	rs6134243	0.9	1
  hCV2529211	rs17189710	hCV2529246	rs6040619	0.9	1
  hCV2529211	rs17189710	hCV27367681	rs2876227	0.9	0.9616
  hCV2529211	rs17189710	hCV27367708	rs1009748	0.9	1
  hCV2529211	rs17189710	hCV29840965	rs6040644	0.9	1
  hCV2529211	rs17189710	hCV30057061	rs6033138	0.9	1
  hCV2529211	rs17189710	hCV30093270	rs6040625	0.9	1
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  hCV2529211	rs17189710	hCV30453433	rs6131208	0.9	0.9565
  hCV2529211	rs17189710	hCV30615489	rs6040630	0.9	0.9225
  hCV2529211	rs17189710	hCV32274419	rs13038146	0.9	1
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  hCV2529230	rs4444612	hCV30453433	rs6131208	0.9	0.9565
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  hCV2529231	rs4315598	hCV2529241	rs6134243	0.9	1
  hCV2529231	rs4315598	hCV2529246	rs6040619	0.9	1
  hCV2529231	rs4315598	hCV27367681	rs2876227	0.9	0.9616
  hCV2529231	rs4315598	hCV27367708	rs1009748	0.9	1
  hCV2529231	rs4315598	hCV29840965	rs6040644	0.9	1
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  hCV2529231	rs4315598	hCV30417550	rs6040634	0.9	1
  hCV2529231	rs4315598	hCV30453433	rs6131208	0.9	0.9565
  hCV2529231	rs4315598	hCV30615489	rs6040630	0.9	0.9225
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  hCV2529239	rs6040638	hCV2529211	rs17189710	0.9	1
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  hCV2529239	rs6040638	hCV27367681	rs2876227	0.9	0.9616
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  hCV2529239	rs6040638	hCV29840965	rs6040644	0.9	1
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  hCV2529239	rs6040638	hCV30453433	rs6131208	0.9	0.9565
  hCV2529239	rs6040638	hCV30615489	rs6040630	0.9	0.9225
  hCV2529239	rs6040638	hCV32274419	rs13038146	0.9	1
  hCV2529239	rs6040638	hCV330228	rs6040668	0.9	1
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  hCV2529241	rs6134243	hCV27367681	rs2876227	0.9	0.9649
  hCV2529241	rs6134243	hCV27367708	rs1009748	0.9	1
  hCV2529241	rs6134243	hCV29840965	rs6040644	0.9	1
  hCV2529241	rs6134243	hCV30057061	rs6033138	0.9	1
  hCV2529241	rs6134243	hCV30093270	rs6040625	0.9	1
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  hCV2529241	rs6134243	hCV30417550	rs6040634	0.9	1
  hCV2529241	rs6134243	hCV30453433	rs6131208	0.9	0.9585
  hCV2529241	rs6134243	hCV30615489	rs6040630	0.9	0.9294
  hCV2529241	rs6134243	hCV32274419	rs13038146	0.9	1
  hCV2529241	rs6134243	hCV330228	rs6040668	0.9	1
  hCV2529246	rs6040619	hCV2529198	rs742827	0.9	0.9596
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  hCV2529246	rs6040619	hCV2529224	rs2327412	0.9	1
  hCV2529246	rs6040619	hCV2529230	rs4444612	0.9	1
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  hCV2529246	rs6040619	hCV27367681	rs2876227	0.9	0.9616
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  hCV2529246	rs6040619	hCV29840965	rs6040644	0.9	1
  hCV2529246	rs6040619	hCV30057061	rs6033138	0.9	1
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  hCV2529246	rs6040619	hCV30453433	rs6131208	0.9	0.9565
  hCV2529246	rs6040619	hCV30615489	rs6040630	0.9	0.9225
  hCV2529246	rs6040619	hCV32274419	rs13038146	0.9	1
  hCV2529246	rs6040619	hCV330228	rs6040668	0.9	1
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  hCV2575318	rs7711358	hCV11819782	rs12719415	0.9	0.927
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  hCV2745828	rs10879240	hCV27952503	rs4760785	0.9	0.9664
  hCV2745828	rs10879240	hCV29120310	rs7298255	0.9	0.9274
  hCV2745828	rs10879240	hCV31190748	rs7959965	0.9	0.9274
  hCV2745828	rs10879240	hCV31190777	rs10784891	0.9	0.9235
  hCV2745828	rs10879240	hDV72015086	rs7956274	0.9	0.9285
  hCV27872026	rs4851531	hCV16126066	rs2110564	0.9	0.9638
  hCV27872026	rs4851531	hCV2676440	rs6722640	0.9	0.9638
  hCV27872026	rs4851531	hCV349805	rs4851529	0.9	0.9646
  hCV27872026	rs4851531	hCV8905894	rs974950	0.9	0.9812
  hCV27894109	rs4879931	hCV29338373	rs7035913	0.9	1
  hCV27894109	rs4879931	hDV70921009	rs17204908	0.9	1
  hCV27933339	rs4586678	hCV26135665	rs4390811	0.9	0.96
  hCV27933339	rs4586678	hCV26771384	rs10865197	0.9	1
  hCV27933339	rs4586678	hCV26771389	rs10183431	0.9	1
  hCV27933339	rs4586678	hCV27875215	rs4346434	0.9	0.922
  hCV27933339	rs4586678	hCV29229284	rs6741066	0.9	0.9591
  hCV27933339	rs4586678	hCV30817981	rs6723119	0.9	0.96
  hCV27933339	rs4586678	hCV375079	rs9309112	0.9	0.92
  hCV27933339	rs4586678	hCV375083	rs10206724	0.9	1
  hCV27933339	rs4586678	hCV375090	rs4450660	0.9	1
  hCV27933339	rs4586678	hCV514334	rs6544721	0.9	0.961
  hCV27952502	rs4760894	hCV11686367	rs7955901	0.9	0.9644
  hCV27952502	rs4760894	hCV171102	rs7313973	0.9	0.9603
  hCV27952502	rs4760894	hCV240133	rs4760895	0.9	1
  hCV27952502	rs4760894	hCV240134	rs7138300	0.9	1
  hCV27952502	rs4760894	hCV2745815	rs1512991	0.9	0.9668
  hCV27952502	rs4760894	hCV2745822	rs1913201	0.9	1
  hCV27952502	rs4760894	hCV2745828	rs10879240	0.9	0.9664
  hCV27952502	rs4760894	hCV27952503	rs4760785	0.9	1
  hCV27952502	rs4760894	hCV29120310	rs7298255	0.9	0.9644
  hCV27952502	rs4760894	hCV31190748	rs7959965	0.9	0.9644
  hCV27952502	rs4760894	hCV31190777	rs10784891	0.9	0.962
  hCV27952502	rs4760894	hDV72015086	rs7956274	0.9	0.9649
  hCV27952503	rs4760785	hCV11686367	rs7955901	0.9	0.9644
  hCV27952503	rs4760785	hCV171102	rs7313973	0.9	0.9603
  hCV27952503	rs4760785	hCV240133	rs4760895	0.9	1
  hCV27952503	rs4760785	hCV240134	rs7138300	0.9	1
  hCV27952503	rs4760785	hCV2745815	rs1512991	0.9	0.9668
  hCV27952503	rs4760785	hCV2745822	rs1913201	0.9	1
  hCV27952503	rs4760785	hCV2745828	rs10879240	0.9	0.9664
  hCV27952503	rs4760785	hCV27952502	rs4760894	0.9	1
  hCV27952503	rs4760785	hCV29120310	rs7298255	0.9	0.9644
  hCV27952503	rs4760785	hCV31190748	rs7959965	0.9	0.9644
  hCV27952503	rs4760785	hCV31190777	rs10784891	0.9	0.962
  hCV27952503	rs4760785	hDV72015086	rs7956274	0.9	0.9649
  hCV27974149	rs4964416	hCV29121666	rs6539231	0.9	0.9266
  hCV27996154	rs4836502	hCV11819780	rs12153185	0.9	1
  hCV27996154	rs4836502	hCV11819782	rs12719415	0.9	1
  hCV27996154	rs4836502	hCV2575318	rs7711358	0.9	0.927
  hCV27996154	rs4836502	hCV2575336	rs2418541	0.9	0.927
  hCV27996154	rs4836502	hCV2575340	rs11242020	0.9	0.927
  hCV27996154	rs4836502	hCV26478744	rs2016194	0.9	0.9198
  hCV27996154	rs4836502	hCV26478745	rs2108426	0.9	0.9135
  hCV27996154	rs4836502	hCV26478747	rs2190598	0.9	1
  hCV27996154	rs4836502	hCV26478763	rs2418542	0.9	0.927
  hCV27996154	rs4836502	hCV2961244	rs2418548	0.9	1
  hCV27996154	rs4836502	hCV2961250	rs4836507	0.9	1
  hCV27996154	rs4836502	hCV2961252	rs10067895	0.9	1
  hCV27996154	rs4836502	hCV2961253	rs2190600	0.9	1
  hCV27996154	rs4836502	hCV2961259	rs11242023	0.9	0.9621
  hCV27996154	rs4836502	hCV2961260	rs11242022	0.9	1
  hCV27996154	rs4836502	hCV2961261	rs11242021	0.9	1
  hCV27996154	rs4836502	hCV2961267	rs1476714	0.9	1
  hCV27996154	rs4836502	hCV2961268	rs2108425	0.9	1
  hCV27996154	rs4836502	hCV2961269	rs2158958	0.9	1
  hCV27996154	rs4836502	hCV2961270	rs9327555	0.9	1
  hCV27996154	rs4836502	hCV2961278	rs7446891	0.9	1
  hCV27996154	rs4836502	hCV2961280	rs10520072	0.9	1
  hCV27996154	rs4836502	hCV2961282	rs917295	0.9	1
  hCV27996154	rs4836502	hCV2961284	rs10054055	0.9	0.9616
  hCV27996154	rs4836502	hCV2961296	rs10051148	0.9	0.9623
  hCV27996154	rs4836502	hCV2961297	rs2158961	0.9	0.9634
  hCV27996154	rs4836502	hCV2961306	rs264129	0.9	0.9232
  hCV27996154	rs4836502	hCV30621656	rs10478919	0.9	0.927
  hCV27996154	rs4836502	hCV31237567	rs11749272	0.9	0.927
  hCV27996154	rs4836502	hCV346713	rs1990023	0.9	0.9232
  hCV27996154	rs4836502	hCV546489	rs264122	0.9	0.9616
  hCV27996154	rs4836502	hCV8932829	rs1116596	0.9	0.927
  hCV2881200	rs2052428	hCV2881217	rs10735411	0.9	0.9234
  hCV2881200	rs2052428	hCV31198182	rs10778446	0.9	0.9234
  hCV29012564	rs7338174	hCV29012561	rs7333988	0.9	0.9184
  hCV29120310	rs7298255	hCV11686367	rs7955901	0.9	0.9442
  hCV29120310	rs7298255	hCV11686374	rs7957932	0.9	0.9161
  hCV29120310	rs7298255	hCV171102	rs7313973	0.9	0.9568
  hCV29120310	rs7298255	hCV240133	rs4760895	0.9	0.9644
  hCV29120310	rs7298255	hCV2745805	rs7132840	0.9	0.9268
  hCV29120310	rs7298255	hCV2745807	rs2063591	0.9	0.9303
  hCV29120310	rs7298255	hCV2745815	rs1512991	0.9	1
  hCV29120310	rs7298255	hCV2745828	rs10879240	0.9	0.9274
  hCV29120310	rs7298255	hCV27952502	rs4760894	0.9	0.9644
  hCV29120310	rs7298255	hCV27952503	rs4760785	0.9	0.9644
  hCV29120310	rs7298255	hCV31190748	rs7959965	0.9	1
  hCV29120310	rs7298255	hCV31190777	rs10784891	0.9	1
  hCV29120310	rs7298255	hDV72015086	rs7956274	0.9	1
  hCV29121666	rs6539231	hCV27974149	rs4964416	0.9	0.9266
  hCV29121666	rs6539231	hCV2881196	rs878612	0.9	0.9637
  hCV29121666	rs6539231	hCV29121664	rs7970318	0.9	0.9078
  hCV29121666	rs6539231	hCV29121665	rs6539230	0.9	0.9078
  hCV29268001	rs7939893	hCV26881087	rs4472926	0.9	0.9787
  hCV2961244	rs2418548	hCV11819780	rs12153185	0.9	1
  hCV2961244	rs2418548	hCV11819782	rs12719415	0.9	1
  hCV2961244	rs2418548	hCV2575318	rs7711358	0.9	0.9232
  hCV2961244	rs2418548	hCV2575336	rs2418541	0.9	0.9232
  hCV2961244	rs2418548	hCV2575340	rs11242020	0.9	0.9232
  hCV2961244	rs2418548	hCV26478744	rs2016194	0.9	1
  hCV2961244	rs2418548	hCV26478745	rs2108426	0.9	1
  hCV2961244	rs2418548	hCV26478747	rs2190598	0.9	1
  hCV2961244	rs2418548	hCV26478763	rs2418542	0.9	0.9232
  hCV2961244	rs2418548	hCV27996154	rs4836502	0.9	1
  hCV2961244	rs2418548	hCV2961250	rs4836507	0.9	1
  hCV2961244	rs2418548	hCV2961252	rs10067895	0.9	1
  hCV2961244	rs2418548	hCV2961253	rs2190600	0.9	1
  hCV2961244	rs2418548	hCV2961259	rs11242023	0.9	0.9571
  hCV2961244	rs2418548	hCV2961260	rs11242022	0.9	0.9785
  hCV2961244	rs2418548	hCV2961261	rs11242021	0.9	1
  hCV2961244	rs2418548	hCV2961267	rs1476714	0.9	1
  hCV2961244	rs2418548	hCV2961268	rs2108425	0.9	1
  hCV2961244	rs2418548	hCV2961269	rs2158958	0.9	1
  hCV2961244	rs2418548	hCV2961270	rs9327555	0.9	1
  hCV2961244	rs2418548	hCV2961278	rs7446891	0.9	1
  hCV2961244	rs2418548	hCV2961280	rs10520072	0.9	1
  hCV2961244	rs2418548	hCV2961282	rs917295	0.9	1
  hCV2961244	rs2418548	hCV2961284	rs10054055	0.9	0.9573
  hCV2961244	rs2418548	hCV2961296	rs10051148	0.9	0.9608
  hCV2961244	rs2418548	hCV2961297	rs2158961	0.9	0.9616
  hCV2961244	rs2418548	hCV2961306	rs264129	0.9	0.9358
  hCV2961244	rs2418548	hCV30621656	rs10478919	0.9	0.9232
  hCV2961244	rs2418548	hCV31237567	rs11749272	0.9	0.9232
  hCV2961244	rs2418548	hCV346713	rs1990023	0.9	0.9358
  hCV2961244	rs2418548	hCV546489	rs264122	0.9	0.9573
  hCV2961244	rs2418548	hCV8932829	rs1116596	0.9	0.9232
  hCV2961250	rs4836507	hCV11819780	rs12153185	0.9	1
  hCV2961250	rs4836507	hCV11819782	rs12719415	0.9	1
  hCV2961250	rs4836507	hCV2575318	rs7711358	0.9	0.927
  hCV2961250	rs4836507	hCV2575336	rs2418541	0.9	0.927
  hCV2961250	rs4836507	hCV2575340	rs11242020	0.9	0.927
  hCV2961250	rs4836507	hCV26478744	rs2016194	0.9	0.9198
  hCV2961250	rs4836507	hCV26478745	rs2108426	0.9	0.9135
  hCV2961250	rs4836507	hCV26478747	rs2190598	0.9	1
  hCV2961250	rs4836507	hCV26478763	rs2418542	0.9	0.927
  hCV2961250	rs4836507	hCV27996154	rs4836502	0.9	1
  hCV2961250	rs4836507	hCV2961244	rs2418548	0.9	1
  hCV2961250	rs4836507	hCV2961252	rs10067895	0.9	1
  hCV2961250	rs4836507	hCV2961253	rs2190600	0.9	1
  hCV2961250	rs4836507	hCV2961259	rs11242023	0.9	0.9621
  hCV2961250	rs4836507	hCV2961260	rs11242022	0.9	1
  hCV2961250	rs4836507	hCV2961261	rs11242021	0.9	1
  hCV2961250	rs4836507	hCV2961267	rs1476714	0.9	1
  hCV2961250	rs4836507	hCV2961268	rs2108425	0.9	1
  hCV2961250	rs4836507	hCV2961269	rs2158958	0.9	1
  hCV2961250	rs4836507	hCV2961270	rs9327555	0.9	1
  hCV2961250	rs4836507	hCV2961278	rs7446891	0.9	1
  hCV2961250	rs4836507	hCV2961280	rs10520072	0.9	1
  hCV2961250	rs4836507	hCV2961282	rs917295	0.9	1
  hCV2961250	rs4836507	hCV2961284	rs10054055	0.9	0.9616
  hCV2961250	rs4836507	hCV2961296	rs10051148	0.9	0.9623
  hCV2961250	rs4836507	hCV2961297	rs2158961	0.9	0.9634
  hCV2961250	rs4836507	hCV2961306	rs264129	0.9	0.9232
  hCV2961250	rs4836507	hCV30621656	rs10478919	0.9	0.927
  hCV2961250	rs4836507	hCV31237567	rs11749272	0.9	0.927
  hCV2961250	rs4836507	hCV346713	rs1990023	0.9	0.9232
  hCV2961250	rs4836507	hCV546489	rs264122	0.9	0.9616
  hCV2961250	rs4836507	hCV8932829	rs1116596	0.9	0.927
  hCV2961252	rs10067895	hCV11819780	rs12153185	0.9	1
  hCV2961252	rs10067895	hCV11819782	rs12719415	0.9	1
  hCV2961252	rs10067895	hCV2575318	rs7711358	0.9	0.927
  hCV2961252	rs10067895	hCV2575336	rs2418541	0.9	0.927
  hCV2961252	rs10067895	hCV2575340	rs11242020	0.9	0.927
  hCV2961252	rs10067895	hCV26478744	rs2016194	0.9	0.9198
  hCV2961252	rs10067895	hCV26478745	rs2108426	0.9	0.9135
  hCV2961252	rs10067895	hCV26478747	rs2190598	0.9	1
  hCV2961252	rs10067895	hCV26478763	rs2418542	0.9	0.927
  hCV2961252	rs10067895	hCV27996154	rs4836502	0.9	1
  hCV2961252	rs10067895	hCV2961244	rs2418548	0.9	1
  hCV2961252	rs10067895	hCV2961250	rs4836507	0.9	1
  hCV2961252	rs10067895	hCV2961253	rs2190600	0.9	1
  hCV2961252	rs10067895	hCV2961259	rs11242023	0.9	0.9621
  hCV2961252	rs10067895	hCV2961260	rs11242022	0.9	1
  hCV2961252	rs10067895	hCV2961261	rs11242021	0.9	1
  hCV2961252	rs10067895	hCV2961267	rs1476714	0.9	1
  hCV2961252	rs10067895	hCV2961268	rs2108425	0.9	1
  hCV2961252	rs10067895	hCV2961269	rs2158958	0.9	1
  hCV2961252	rs10067895	hCV2961270	rs9327555	0.9	1
  hCV2961252	rs10067895	hCV2961278	rs7446891	0.9	1
  hCV2961252	rs10067895	hCV2961280	rs10520072	0.9	1
  hCV2961252	rs10067895	hCV2961282	rs917295	0.9	1
  hCV2961252	rs10067895	hCV2961284	rs10054055	0.9	0.9616
  hCV2961252	rs10067895	hCV2961296	rs10051148	0.9	0.9623
  hCV2961252	rs10067895	hCV2961297	rs2158961	0.9	0.9634
  hCV2961252	rs10067895	hCV2961306	rs264129	0.9	0.9232
  hCV2961252	rs10067895	hCV30621656	rs10478919	0.9	0.927
  hCV2961252	rs10067895	hCV31237567	rs11749272	0.9	0.927
  hCV2961252	rs10067895	hCV346713	rs1990023	0.9	0.9232
  hCV2961252	rs10067895	hCV546489	rs264122	0.9	0.9616
  hCV2961252	rs10067895	hCV8932829	rs1116596	0.9	0.927
  hCV2961253	rs2190600	hCV11819780	rs12153185	0.9	1
  hCV2961253	rs2190600	hCV11819782	rs12719415	0.9	1
  hCV2961253	rs2190600	hCV2575318	rs7711358	0.9	0.927
  hCV2961253	rs2190600	hCV2575336	rs2418541	0.9	0.927
  hCV2961253	rs2190600	hCV2575340	rs11242020	0.9	0.927
  hCV2961253	rs2190600	hCV26478744	rs2016194	0.9	0.9198
  hCV2961253	rs2190600	hCV26478745	rs2108426	0.9	0.9135
  hCV2961253	rs2190600	hCV26478747	rs2190598	0.9	1
  hCV2961253	rs2190600	hCV26478763	rs2418542	0.9	0.927
  hCV2961253	rs2190600	hCV27996154	rs4836502	0.9	1
  hCV2961253	rs2190600	hCV2961244	rs2418548	0.9	1
  hCV2961253	rs2190600	hCV2961250	rs4836507	0.9	1
  hCV2961253	rs2190600	hCV2961252	rs10067895	0.9	1
  hCV2961253	rs2190600	hCV2961259	rs11242023	0.9	0.9621
  hCV2961253	rs2190600	hCV2961260	rs11242022	0.9	1
  hCV2961253	rs2190600	hCV2961261	rs11242021	0.9	1
  hCV2961253	rs2190600	hCV2961267	rs1476714	0.9	1
  hCV2961253	rs2190600	hCV2961268	rs2108425	0.9	1
  hCV2961253	rs2190600	hCV2961269	rs2158958	0.9	1
  hCV2961253	rs2190600	hCV2961270	rs9327555	0.9	1
  hCV2961253	rs2190600	hCV2961278	rs7446891	0.9	1
  hCV2961253	rs2190600	hCV2961280	rs10520072	0.9	1
  hCV2961253	rs2190600	hCV2961282	rs917295	0.9	1
  hCV2961253	rs2190600	hCV2961284	rs10054055	0.9	0.9616
  hCV2961253	rs2190600	hCV2961296	rs10051148	0.9	0.9623
  hCV2961253	rs2190600	hCV2961297	rs2158961	0.9	0.9634
  hCV2961253	rs2190600	hCV2961306	rs264129	0.9	0.9232
  hCV2961253	rs2190600	hCV30621656	rs10478919	0.9	0.927
  hCV2961253	rs2190600	hCV31237567	rs11749272	0.9	0.927
  hCV2961253	rs2190600	hCV346713	rs1990023	0.9	0.9232
  hCV2961253	rs2190600	hCV546489	rs264122	0.9	0.9616
  hCV2961253	rs2190600	hCV8932829	rs1116596	0.9	0.927
  hCV2961259	rs11242023	hCV11819780	rs12153185	0.9	0.9571
  hCV2961259	rs11242023	hCV11819782	rs12719415	0.9	0.9621
  hCV2961259	rs11242023	hCV26478744	rs2016194	0.9	0.9587
  hCV2961259	rs11242023	hCV26478745	rs2108426	0.9	0.9557
  hCV2961259	rs11242023	hCV26478747	rs2190598	0.9	0.9604
  hCV2961259	rs11242023	hCV27996154	rs4836502	0.9	0.9621
  hCV2961259	rs11242023	hCV2961244	rs2418548	0.9	0.9571
  hCV2961259	rs11242023	hCV2961250	rs4836507	0.9	0.9621
  hCV2961259	rs11242023	hCV2961252	rs10067895	0.9	0.9621
  hCV2961259	rs11242023	hCV2961253	rs2190600	0.9	0.9621
  hCV2961259	rs11242023	hCV2961260	rs11242022	0.9	0.9785
  hCV2961259	rs11242023	hCV2961261	rs11242021	0.9	0.9613
  hCV2961259	rs11242023	hCV2961267	rs1476714	0.9	0.9592
  hCV2961259	rs11242023	hCV2961268	rs2108425	0.9	0.9621
  hCV2961259	rs11242023	hCV2961269	rs2158958	0.9	0.9621
  hCV2961259	rs11242023	hCV2961270	rs9327555	0.9	0.9621
  hCV2961259	rs11242023	hCV2961278	rs7446891	0.9	0.9621
  hCV2961259	rs11242023	hCV2961280	rs10520072	0.9	0.9621
  hCV2961259	rs11242023	hCV2961282	rs917295	0.9	0.9621
  hCV2961259	rs11242023	hCV2961284	rs10054055	0.9	0.9573
  hCV2961259	rs11242023	hCV2961296	rs10051148	0.9	0.9236
  hCV2961259	rs11242023	hCV2961297	rs2158961	0.9	0.9252
  hCV2961259	rs11242023	hCV2961306	rs264129	0.9	0.9358
  hCV2961259	rs11242023	hCV346713	rs1990023	0.9	0.9358
  hCV2961259	rs11242023	hCV546489	rs264122	0.9	0.9573
  hCV2961260	rs11242022	hCV11819780	rs12153185	0.9	0.9785
  hCV2961260	rs11242022	hCV11819782	rs12719415	0.9	1
  hCV2961260	rs11242022	hCV2575318	rs7711358	0.9	0.9232
  hCV2961260	rs11242022	hCV2575336	rs2418541	0.9	0.9232
  hCV2961260	rs11242022	hCV2575340	rs11242020	0.9	0.9232
  hCV2961260	rs11242022	hCV26478744	rs2016194	0.9	1
  hCV2961260	rs11242022	hCV26478745	rs2108426	0.9	1
  hCV2961260	rs11242022	hCV26478747	rs2190598	0.9	1
  hCV2961260	rs11242022	hCV26478763	rs2418542	0.9	0.9232
  hCV2961260	rs11242022	hCV27996154	rs4836502	0.9	1
  hCV2961260	rs11242022	hCV2961244	rs2418548	0.9	0.9785
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  hCV2961260	rs11242022	hCV2961252	rs10067895	0.9	1
  hCV2961260	rs11242022	hCV2961253	rs2190600	0.9	1
  hCV2961260	rs11242022	hCV2961259	rs11242023	0.9	0.9785
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  hCV2961260	rs11242022	hCV2961268	rs2108425	0.9	1
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  hCV2961260	rs11242022	hCV2961278	rs7446891	0.9	1
  hCV2961260	rs11242022	hCV2961280	rs10520072	0.9	1
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  hCV2961260	rs11242022	hCV2961284	rs10054055	0.9	0.9783
  hCV2961260	rs11242022	hCV2961296	rs10051148	0.9	0.9608
  hCV2961260	rs11242022	hCV2961297	rs2158961	0.9	0.9616
  hCV2961260	rs11242022	hCV2961306	rs264129	0.9	0.9567
  hCV2961260	rs11242022	hCV30621656	rs10478919	0.9	0.9232
  hCV2961260	rs11242022	hCV31237567	rs11749272	0.9	0.9232
  hCV2961260	rs11242022	hCV346713	rs1990023	0.9	0.9567
  hCV2961260	rs11242022	hCV546489	rs264122	0.9	0.9783
  hCV2961260	rs11242022	hCV8932829	rs1116596	0.9	0.9232
  hCV2961261	rs11242021	hCV11819780	rs12153185	0.9	1
  hCV2961261	rs11242021	hCV11819782	rs12719415	0.9	1
  hCV2961261	rs11242021	hCV2575318	rs7711358	0.9	0.9255
  hCV2961261	rs11242021	hCV2575336	rs2418541	0.9	0.9255
  hCV2961261	rs11242021	hCV2575340	rs11242020	0.9	0.9255
  hCV2961261	rs11242021	hCV26478744	rs2016194	0.9	0.9198
  hCV2961261	rs11242021	hCV26478745	rs2108426	0.9	0.9135
  hCV2961261	rs11242021	hCV26478747	rs2190598	0.9	1
  hCV2961261	rs11242021	hCV26478763	rs2418542	0.9	0.9255
  hCV2961261	rs11242021	hCV27996154	rs4836502	0.9	1
  hCV2961261	rs11242021	hCV2961244	rs2418548	0.9	1
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  hCV2961261	rs11242021	hCV2961252	rs10067895	0.9	1
  hCV2961261	rs11242021	hCV2961253	rs2190600	0.9	1
  hCV2961261	rs11242021	hCV2961259	rs11242023	0.9	0.9613
  hCV2961261	rs11242021	hCV2961260	rs11242022	0.9	1
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  hCV2961261	rs11242021	hCV2961268	rs2108425	0.9	1
  hCV2961261	rs11242021	hCV2961269	rs2158958	0.9	1
  hCV2961261	rs11242021	hCV2961270	rs9327555	0.9	1
  hCV2961261	rs11242021	hCV2961278	rs7446891	0.9	1
  hCV2961261	rs11242021	hCV2961280	rs10520072	0.9	1
  hCV2961261	rs11242021	hCV2961282	rs917295	0.9	1
  hCV2961261	rs11242021	hCV2961284	rs10054055	0.9	0.9608
  hCV2961261	rs11242021	hCV2961296	rs10051148	0.9	0.9615
  hCV2961261	rs11242021	hCV2961297	rs2158961	0.9	0.9627
  hCV2961261	rs11242021	hCV2961306	rs264129	0.9	0.9216
  hCV2961261	rs11242021	hCV30621656	rs10478919	0.9	0.9255
  hCV2961261	rs11242021	hCV31237567	rs11749272	0.9	0.9255
  hCV2961261	rs11242021	hCV346713	rs1990023	0.9	0.9216
  hCV2961261	rs11242021	hCV546489	rs264122	0.9	0.9608
  hCV2961261	rs11242021	hCV8932829	rs1116596	0.9	0.9255
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  hCV2961267	rs1476714	hCV11819782	rs12719415	0.9	1
  hCV2961267	rs1476714	hCV2575318	rs7711358	0.9	0.9607
  hCV2961267	rs1476714	hCV2575336	rs2418541	0.9	0.9607
  hCV2961267	rs1476714	hCV2575340	rs11242020	0.9	0.9607
  hCV2961267	rs1476714	hCV26478744	rs2016194	0.9	0.9152
  hCV2961267	rs1476714	hCV26478745	rs2108426	0.9	0.9081
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  hCV2961267	rs1476714	hCV26478763	rs2418542	0.9	0.9607
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  hCV2961267	rs1476714	hCV30621656	rs10478919	0.9	0.9607
  hCV2961267	rs1476714	hCV31237567	rs11749272	0.9	0.9607
  hCV2961267	rs1476714	hCV346713	rs1990023	0.9	0.9587
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  hCV2961268	rs2108425	hCV2575340	rs11242020	0.9	0.927
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  hCV2961269	rs2158958	hCV31237567	rs11749272	0.9	0.927
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  hCV2961280	rs10520072	hCV8932829	rs1116596	0.9	0.927
  hCV2961282	rs917295	hCV11819780	rs12153185	0.9	1
  hCV2961282	rs917295	hCV11819782	rs12719415	0.9	1
  hCV2961282	rs917295	hCV2575318	rs7711358	0.9	0.927
  hCV2961282	rs917295	hCV2575336	rs2418541	0.9	0.927
  hCV2961282	rs917295	hCV2575340	rs11242020	0.9	0.927
  hCV2961282	rs917295	hCV26478744	rs2016194	0.9	0.9197
  hCV2961282	rs917295	hCV26478745	rs2108426	0.9	0.9134
  hCV2961282	rs917295	hCV26478747	rs2190598	0.9	1
  hCV2961282	rs917295	hCV26478763	rs2418542	0.9	0.927
  hCV2961282	rs917295	hCV27996154	rs4836502	0.9	1
  hCV2961282	rs917295	hCV2961244	rs2418548	0.9	1
  hCV2961282	rs917295	hCV2961250	rs4836507	0.9	1
  hCV2961282	rs917295	hCV2961252	rs10067895	0.9	1
  hCV2961282	rs917295	hCV2961253	rs2190600	0.9	1
  hCV2961282	rs917295	hCV2961259	rs11242023	0.9	0.9621
  hCV2961282	rs917295	hCV2961260	rs11242022	0.9	1
  hCV2961282	rs917295	hCV2961261	rs11242021	0.9	1
  hCV2961282	rs917295	hCV2961267	rs1476714	0.9	1
  hCV2961282	rs917295	hCV2961268	rs2108425	0.9	1
  hCV2961282	rs917295	hCV2961269	rs2158958	0.9	1
  hCV2961282	rs917295	hCV2961270	rs9327555	0.9	1
  hCV2961282	rs917295	hCV2961278	rs7446891	0.9	1
  hCV2961282	rs917295	hCV2961280	rs10520072	0.9	1
  hCV2961282	rs917295	hCV2961284	rs10054055	0.9	0.9616
  hCV2961282	rs917295	hCV2961296	rs10051148	0.9	0.9623
  hCV2961282	rs917295	hCV2961297	rs2158961	0.9	0.9634
  hCV2961282	rs917295	hCV2961306	rs264129	0.9	0.9232
  hCV2961282	rs917295	hCV30621656	rs10478919	0.9	0.927
  hCV2961282	rs917295	hCV31237567	rs11749272	0.9	0.927
  hCV2961282	rs917295	hCV346713	rs1990023	0.9	0.9232
  hCV2961282	rs917295	hCV546489	rs264122	0.9	0.9616
  hCV2961282	rs917295	hCV8932829	rs1116596	0.9	0.927
  hCV2961284	rs10054055	hCV11819780	rs12153185	0.9	0.9573
  hCV2961284	rs10054055	hCV11819782	rs12719415	0.9	0.9616
  hCV2961284	rs10054055	hCV2575318	rs7711358	0.9	0.9616
  hCV2961284	rs10054055	hCV2575336	rs2418541	0.9	0.9616
  hCV2961284	rs10054055	hCV2575340	rs11242020	0.9	0.9616
  hCV2961284	rs10054055	hCV26478744	rs2016194	0.9	0.9581
  hCV2961284	rs10054055	hCV26478745	rs2108426	0.9	1
  hCV2961284	rs10054055	hCV26478747	rs2190598	0.9	0.96
  hCV2961284	rs10054055	hCV26478763	rs2418542	0.9	0.9616
  hCV2961284	rs10054055	hCV27996154	rs4836502	0.9	0.9616
  hCV2961284	rs10054055	hCV2961244	rs2418548	0.9	0.9573
  hCV2961284	rs10054055	hCV2961250	rs4836507	0.9	0.9616
  hCV2961284	rs10054055	hCV2961252	rs10067895	0.9	0.9616
  hCV2961284	rs10054055	hCV2961253	rs2190600	0.9	0.9616
  hCV2961284	rs10054055	hCV2961259	rs11242023	0.9	0.9573
  hCV2961284	rs10054055	hCV2961260	rs11242022	0.9	0.9783
  hCV2961284	rs10054055	hCV2961261	rs11242021	0.9	0.9608
  hCV2961284	rs10054055	hCV2961267	rs1476714	0.9	0.9587
  hCV2961284	rs10054055	hCV2961268	rs2108425	0.9	0.9616
  hCV2961284	rs10054055	hCV2961269	rs2158958	0.9	0.9616
  hCV2961284	rs10054055	hCV2961270	rs9327555	0.9	0.9616
  hCV2961284	rs10054055	hCV2961278	rs7446891	0.9	0.9616
  hCV2961284	rs10054055	hCV2961280	rs10520072	0.9	0.9616
  hCV2961284	rs10054055	hCV2961282	rs917295	0.9	0.9616
  hCV2961284	rs10054055	hCV2961296	rs10051148	0.9	1
  hCV2961284	rs10054055	hCV2961297	rs2158961	0.9	1
  hCV2961284	rs10054055	hCV2961306	rs264129	0.9	0.9783
  hCV2961284	rs10054055	hCV29666186	rs6871041	0.9	0.9189
  hCV2961284	rs10054055	hCV30621656	rs10478919	0.9	0.9616
  hCV2961284	rs10054055	hCV31237567	rs11749272	0.9	0.9616
  hCV2961284	rs10054055	hCV346713	rs1990023	0.9	0.9783
  hCV2961284	rs10054055	hCV546489	rs264122	0.9	1
  hCV2961284	rs10054055	hCV8932829	rs1116596	0.9	0.9616
  hCV2961296	rs10051148	hCV11819780	rs12153185	0.9	0.9608
  hCV2961296	rs10051148	hCV11819782	rs12719415	0.9	0.9623
  hCV2961296	rs10051148	hCV2575318	rs7711358	0.9	0.9623
  hCV2961296	rs10051148	hCV2575336	rs2418541	0.9	0.9623
  hCV2961296	rs10051148	hCV2575340	rs11242020	0.9	0.9623
  hCV2961296	rs10051148	hCV26478744	rs2016194	0.9	0.9589
  hCV2961296	rs10051148	hCV26478745	rs2108426	0.9	1
  hCV2961296	rs10051148	hCV26478747	rs2190598	0.9	0.9615
  hCV2961296	rs10051148	hCV26478763	rs2418542	0.9	0.9623
  hCV2961296	rs10051148	hCV27996154	rs4836502	0.9	0.9623
  hCV2961296	rs10051148	hCV2961244	rs2418548	0.9	0.9608
  hCV2961296	rs10051148	hCV2961250	rs4836507	0.9	0.9623
  hCV2961296	rs10051148	hCV2961252	rs10067895	0.9	0.9623
  hCV2961296	rs10051148	hCV2961253	rs2190600	0.9	0.9623
  hCV2961296	rs10051148	hCV2961259	rs11242023	0.9	0.9236
  hCV2961296	rs10051148	hCV2961260	rs11242022	0.9	0.9608
  hCV2961296	rs10051148	hCV2961261	rs11242021	0.9	0.9615
  hCV2961296	rs10051148	hCV2961267	rs1476714	0.9	0.9595
  hCV2961296	rs10051148	hCV2961268	rs2108425	0.9	0.9623
  hCV2961296	rs10051148	hCV2961269	rs2158958	0.9	0.9623
  hCV2961296	rs10051148	hCV2961270	rs9327555	0.9	0.9623
  hCV2961296	rs10051148	hCV2961278	rs7446891	0.9	0.9623
  hCV2961296	rs10051148	hCV2961280	rs10520072	0.9	0.9623
  hCV2961296	rs10051148	hCV2961282	rs917295	0.9	0.9623
  hCV2961296	rs10051148	hCV2961284	rs10054055	0.9	1
  hCV2961296	rs10051148	hCV2961297	rs2158961	0.9	1
  hCV2961296	rs10051148	hCV2961306	rs264129	0.9	0.9608
  hCV2961296	rs10051148	hCV29666186	rs6871041	0.9	0.9202
  hCV2961296	rs10051148	hCV30621656	rs10478919	0.9	0.9623
  hCV2961296	rs10051148	hCV31237567	rs11749272	0.9	0.9623
  hCV2961296	rs10051148	hCV346713	rs1990023	0.9	0.9608
  hCV2961296	rs10051148	hCV546489	rs264122	0.9	1
  hCV2961296	rs10051148	hCV8932829	rs1116596	0.9	0.9623
  hCV2961297	rs2158961	hCV11819780	rs12153185	0.9	0.9616
  hCV2961297	rs2158961	hCV11819782	rs12719415	0.9	0.9634
  hCV2961297	rs2158961	hCV2575318	rs7711358	0.9	0.9634
  hCV2961297	rs2158961	hCV2575336	rs2418541	0.9	0.9634
  hCV2961297	rs2158961	hCV2575340	rs11242020	0.9	0.9634
  hCV2961297	rs2158961	hCV26478745	rs2108426	0.9	0.9135
  hCV2961297	rs2158961	hCV26478747	rs2190598	0.9	0.9619
  hCV2961297	rs2158961	hCV26478763	rs2418542	0.9	0.9634
  hCV2961297	rs2158961	hCV27996154	rs4836502	0.9	0.9634
  hCV2961297	rs2158961	hCV2961244	rs2418548	0.9	0.9616
  hCV2961297	rs2158961	hCV2961250	rs4836507	0.9	0.9634
  hCV2961297	rs2158961	hCV2961252	rs10067895	0.9	0.9634
  hCV2961297	rs2158961	hCV2961253	rs2190600	0.9	0.9634
  hCV2961297	rs2158961	hCV2961259	rs11242023	0.9	0.9252
  hCV2961297	rs2158961	hCV2961260	rs11242022	0.9	0.9616
  hCV2961297	rs2158961	hCV2961261	rs11242021	0.9	0.9627
  hCV2961297	rs2158961	hCV2961267	rs1476714	0.9	0.9607
  hCV2961297	rs2158961	hCV2961268	rs2108425	0.9	0.9634
  hCV2961297	rs2158961	hCV2961269	rs2158958	0.9	0.9634
  hCV2961297	rs2158961	hCV2961270	rs9327555	0.9	0.9634
  hCV2961297	rs2158961	hCV2961278	rs7446891	0.9	0.9634
  hCV2961297	rs2158961	hCV2961280	rs10520072	0.9	0.9634
  hCV2961297	rs2158961	hCV2961282	rs917295	0.9	0.9634
  hCV2961297	rs2158961	hCV2961284	rs10054055	0.9	1
  hCV2961297	rs2158961	hCV2961296	rs10051148	0.9	1
  hCV2961297	rs2158961	hCV2961306	rs264129	0.9	0.9616
  hCV2961297	rs2158961	hCV29666186	rs6871041	0.9	0.9226
  hCV2961297	rs2158961	hCV30621656	rs10478919	0.9	0.9634
  hCV2961297	rs2158961	hCV31237567	rs11749272	0.9	0.9634
  hCV2961297	rs2158961	hCV346713	rs1990023	0.9	0.9616
  hCV2961297	rs2158961	hCV546489	rs264122	0.9	1
  hCV2961297	rs2158961	hCV8932829	rs1116596	0.9	0.9634
  hCV2961306	rs264129	hCV11819780	rs12153185	0.9	0.9358
  hCV2961306	rs264129	hCV11819782	rs12719415	0.9	0.9232
  hCV2961306	rs264129	hCV2575318	rs7711358	0.9	0.9232
  hCV2961306	rs264129	hCV2575336	rs2418541	0.9	0.9232
  hCV2961306	rs264129	hCV2575340	rs11242020	0.9	0.9232
  hCV2961306	rs264129	hCV26478744	rs2016194	0.9	0.9162
  hCV2961306	rs264129	hCV26478745	rs2108426	0.9	0.9557
  hCV2961306	rs264129	hCV26478747	rs2190598	0.9	0.9198
  hCV2961306	rs264129	hCV26478763	rs2418542	0.9	0.9232
  hCV2961306	rs264129	hCV27996154	rs4836502	0.9	0.9232
  hCV2961306	rs264129	hCV2961244	rs2418548	0.9	0.9358
  hCV2961306	rs264129	hCV2961250	rs4836507	0.9	0.9232
  hCV2961306	rs264129	hCV2961252	rs10067895	0.9	0.9232
  hCV2961306	rs264129	hCV2961253	rs2190600	0.9	0.9232
  hCV2961306	rs264129	hCV2961259	rs11242023	0.9	0.9358
  hCV2961306	rs264129	hCV2961260	rs11242022	0.9	0.9567
  hCV2961306	rs264129	hCV2961261	rs11242021	0.9	0.9216
  hCV2961306	rs264129	hCV2961267	rs1476714	0.9	0.9172
  hCV2961306	rs264129	hCV2961268	rs2108425	0.9	0.9232
  hCV2961306	rs264129	hCV2961269	rs2158958	0.9	0.9232
  hCV2961306	rs264129	hCV2961270	rs9327555	0.9	0.9232
  hCV2961306	rs264129	hCV2961278	rs7446891	0.9	0.9232
  hCV2961306	rs264129	hCV2961280	rs10520072	0.9	0.9232
  hCV2961306	rs264129	hCV2961282	rs917295	0.9	0.9232
  hCV2961306	rs264129	hCV2961284	rs10054055	0.9	0.9783
  hCV2961306	rs264129	hCV2961296	rs10051148	0.9	0.9608
  hCV2961306	rs264129	hCV2961297	rs2158961	0.9	0.9616
  hCV2961306	rs264129	hCV30621656	rs10478919	0.9	0.9232
  hCV2961306	rs264129	hCV31237567	rs11749272	0.9	0.9232
  hCV2961306	rs264129	hCV346713	rs1990023	0.9	0.9567
  hCV2961306	rs264129	hCV546489	rs264122	0.9	0.9783
  hCV2961306	rs264129	hCV8932829	rs1116596	0.9	0.9232
  hCV29666186	rs6871041	hCV2961284	rs10054055	0.9	0.9189
  hCV29666186	rs6871041	hCV2961296	rs10051148	0.9	0.9202
  hCV29666186	rs6871041	hCV2961297	rs2158961	0.9	0.9226
  hCV29666186	rs6871041	hCV546489	rs264122	0.9	0.9189
  hCV29840965	rs6040644	hCV2529198	rs742827	0.9	0.9596
  hCV29840965	rs6040644	hCV2529202	rs6040667	0.9	1
  hCV29840965	rs6040644	hCV2529211	rs17189710	0.9	1
  hCV29840965	rs6040644	hCV2529224	rs2327412	0.9	1
  hCV29840965	rs6040644	hCV2529230	rs4444612	0.9	1
  hCV29840965	rs6040644	hCV2529231	rs4315598	0.9	1
  hCV29840965	rs6040644	hCV2529239	rs6040638	0.9	1
  hCV29840965	rs6040644	hCV2529241	rs6134243	0.9	1
  hCV29840965	rs6040644	hCV2529246	rs6040619	0.9	1
  hCV29840965	rs6040644	hCV27367681	rs2876227	0.9	0.9616
  hCV29840965	rs6040644	hCV27367708	rs1009748	0.9	1
  hCV29840965	rs6040644	hCV30057061	rs6033138	0.9	1
  hCV29840965	rs6040644	hCV30093270	rs6040625	0.9	1
  hCV29840965	rs6040644	hCV30129243	rs6040636	0.9	1
  hCV29840965	rs6040644	hCV30218977	rs6040633	0.9	1
  hCV29840965	rs6040644	hCV30417550	rs6040634	0.9	1
  hCV29840965	rs6040644	hCV30453433	rs6131208	0.9	0.9565
  hCV29840965	rs6040644	hCV30615489	rs6040630	0.9	0.9225
  hCV29840965	rs6040644	hCV32274419	rs13038146	0.9	1
  hCV29840965	rs6040644	hCV330228	rs6040668	0.9	1
  hCV29997278	rs9906737	hCV11625525	rs7222186	0.9	1
  hCV29997278	rs9906737	hCV1558080	rs9914580	0.9	1
  hCV29997278	rs9906737	hCV1558085	rs11656608	0.9	1
  hCV29997278	rs9906737	hCV29293441	rs8066502	0.9	1
  hCV29997278	rs9906737	hCV29979212	rs8068714	0.9	1
  hCV30057061	rs6033138	hCV2529198	rs742827	0.9	0.9624
  hCV30057061	rs6033138	hCV2529202	rs6040667	0.9	1
  hCV30057061	rs6033138	hCV2529211	rs17189710	0.9	1
  hCV30057061	rs6033138	hCV2529224	rs2327412	0.9	1
  hCV30057061	rs6033138	hCV2529230	rs4444612	0.9	1
  hCV30057061	rs6033138	hCV2529231	rs4315598	0.9	1
  hCV30057061	rs6033138	hCV2529239	rs6040638	0.9	1
  hCV30057061	rs6033138	hCV2529241	rs6134243	0.9	1
  hCV30057061	rs6033138	hCV2529246	rs6040619	0.9	1
  hCV30057061	rs6033138	hCV27367681	rs2876227	0.9	0.9649
  hCV30057061	rs6033138	hCV27367708	rs1009748	0.9	1
  hCV30057061	rs6033138	hCV29840965	rs6040644	0.9	1
  hCV30057061	rs6033138	hCV30093270	rs6040625	0.9	1
  hCV30057061	rs6033138	hCV30129243	rs6040636	0.9	1
  hCV30057061	rs6033138	hCV30218977	rs6040633	0.9	1
  hCV30057061	rs6033138	hCV30417550	rs6040634	0.9	1
  hCV30057061	rs6033138	hCV30453433	rs6131208	0.9	0.9585
  hCV30057061	rs6033138	hCV30615489	rs6040630	0.9	0.9294
  hCV30057061	rs6033138	hCV32274419	rs13038146	0.9	1
  hCV30057061	rs6033138	hCV330228	rs6040668	0.9	1
  hCV30093270	rs6040625	hCV2529198	rs742827	0.9	0.9624
  hCV30093270	rs6040625	hCV2529202	rs6040667	0.9	1
  hCV30093270	rs6040625	hCV2529211	rs17189710	0.9	1
  hCV30093270	rs6040625	hCV2529224	rs2327412	0.9	1
  hCV30093270	rs6040625	hCV2529230	rs4444612	0.9	1
  hCV30093270	rs6040625	hCV2529231	rs4315598	0.9	1
  hCV30093270	rs6040625	hCV2529239	rs6040638	0.9	1
  hCV30093270	rs6040625	hCV2529241	rs6134243	0.9	1
  hCV30093270	rs6040625	hCV2529246	rs6040619	0.9	1
  hCV30093270	rs6040625	hCV27367681	rs2876227	0.9	0.9649
  hCV30093270	rs6040625	hCV27367708	rs1009748	0.9	1
  hCV30093270	rs6040625	hCV29840965	rs6040644	0.9	1
  hCV30093270	rs6040625	hCV30057061	rs6033138	0.9	1
  hCV30093270	rs6040625	hCV30129243	rs6040636	0.9	1
  hCV30093270	rs6040625	hCV30218977	rs6040633	0.9	1
  hCV30093270	rs6040625	hCV30417550	rs6040634	0.9	1
  hCV30093270	rs6040625	hCV30453433	rs6131208	0.9	0.9585
  hCV30093270	rs6040625	hCV30615489	rs6040630	0.9	0.9294
  hCV30093270	rs6040625	hCV32274419	rs13038146	0.9	1
  hCV30093270	rs6040625	hCV330228	rs6040668	0.9	1
  hCV30129243	rs6040636	hCV2529198	rs742827	0.9	0.9624
  hCV30129243	rs6040636	hCV2529202	rs6040667	0.9	1
  hCV30129243	rs6040636	hCV2529211	rs17189710	0.9	1
  hCV30129243	rs6040636	hCV2529224	rs2327412	0.9	1
  hCV30129243	rs6040636	hCV2529230	rs4444612	0.9	1
  hCV30129243	rs6040636	hCV2529231	rs4315598	0.9	1
  hCV30129243	rs6040636	hCV2529239	rs6040638	0.9	1
  hCV30129243	rs6040636	hCV2529241	rs6134243	0.9	1
  hCV30129243	rs6040636	hCV2529246	rs6040619	0.9	1
  hCV30129243	rs6040636	hCV27367681	rs2876227	0.9	0.9649
  hCV30129243	rs6040636	hCV27367708	rs1009748	0.9	1
  hCV30129243	rs6040636	hCV29840965	rs6040644	0.9	1
  hCV30129243	rs6040636	hCV30057061	rs6033138	0.9	1
  hCV30129243	rs6040636	hCV30093270	rs6040625	0.9	1
  hCV30129243	rs6040636	hCV30218977	rs6040633	0.9	1
  hCV30129243	rs6040636	hCV30417550	rs6040634	0.9	1
  hCV30129243	rs6040636	hCV30453433	rs6131208	0.9	0.9585
  hCV30129243	rs6040636	hCV30615489	rs6040630	0.9	0.9294
  hCV30129243	rs6040636	hCV32274419	rs13038146	0.9	1
  hCV30129243	rs6040636	hCV330228	rs6040668	0.9	1
  hCV30202184	rs6685920	hCV1166098	rs4660234	0.9	1
  hCV30202184	rs6685920	hCV1166103	rs12407412	0.9	1
  hCV30202184	rs6685920	hCV1166105	rs11576627	0.9	1
  hCV30218977	rs6040633	hCV2529198	rs742827	0.9	0.9624
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  hCV330228	rs6040668	hCV2529241	rs6134243	0.9	1
  hCV330228	rs6040668	hCV2529246	rs6040619	0.9	1
  hCV330228	rs6040668	hCV27367681	rs2876227	0.9	0.9649
  hCV330228	rs6040668	hCV27367708	rs1009748	0.9	1
  hCV330228	rs6040668	hCV29840965	rs6040644	0.9	1
  hCV330228	rs6040668	hCV30057061	rs6033138	0.9	1
  hCV330228	rs6040668	hCV30093270	rs6040625	0.9	1
  hCV330228	rs6040668	hCV30129243	rs6040636	0.9	1
  hCV330228	rs6040668	hCV30218977	rs6040633	0.9	1
  hCV330228	rs6040668	hCV30417550	rs6040634	0.9	1
  hCV330228	rs6040668	hCV30453433	rs6131208	0.9	0.9585
  hCV330228	rs6040668	hCV30615489	rs6040630	0.9	0.9294
  hCV330228	rs6040668	hCV32274419	rs13038146	0.9	1
  hCV346713	rs1990023	hCV11819780	rs12153185	0.9	0.9358
  hCV346713	rs1990023	hCV11819782	rs12719415	0.9	0.9232
  hCV346713	rs1990023	hCV2575318	rs7711358	0.9	1
  hCV346713	rs1990023	hCV2575336	rs2418541	0.9	1
  hCV346713	rs1990023	hCV2575340	rs11242020	0.9	1
  hCV346713	rs1990023	hCV26478744	rs2016194	0.9	0.9162
  hCV346713	rs1990023	hCV26478745	rs2108426	0.9	0.9557
  hCV346713	rs1990023	hCV26478747	rs2190598	0.9	0.9199
  hCV346713	rs1990023	hCV26478763	rs2418542	0.9	1
  hCV346713	rs1990023	hCV27996154	rs4836502	0.9	0.9232
  hCV346713	rs1990023	hCV2961244	rs2418548	0.9	0.9358
  hCV346713	rs1990023	hCV2961250	rs4836507	0.9	0.9232
  hCV346713	rs1990023	hCV2961252	rs10067895	0.9	0.9232
  hCV346713	rs1990023	hCV2961253	rs2190600	0.9	0.9232
  hCV346713	rs1990023	hCV2961259	rs11242023	0.9	0.9358
  hCV346713	rs1990023	hCV2961260	rs11242022	0.9	0.9567
  hCV346713	rs1990023	hCV2961261	rs11242021	0.9	0.9216
  hCV346713	rs1990023	hCV2961267	rs1476714	0.9	0.9587
  hCV346713	rs1990023	hCV2961268	rs2108425	0.9	0.9232
  hCV346713	rs1990023	hCV2961269	rs2158958	0.9	0.9232
  hCV346713	rs1990023	hCV2961270	rs9327555	0.9	0.9232
  hCV346713	rs1990023	hCV2961278	rs7446891	0.9	0.9232
  hCV346713	rs1990023	hCV2961280	rs10520072	0.9	0.9232
  hCV346713	rs1990023	hCV2961282	rs917295	0.9	0.9232
  hCV346713	rs1990023	hCV2961284	rs10054055	0.9	0.9783
  hCV346713	rs1990023	hCV2961296	rs10051148	0.9	0.9608
  hCV346713	rs1990023	hCV2961297	rs2158961	0.9	0.9616
  hCV346713	rs1990023	hCV2961306	rs264129	0.9	0.9567
  hCV346713	rs1990023	hCV30621656	rs10478919	0.9	1
  hCV346713	rs1990023	hCV31237567	rs11749272	0.9	1
  hCV346713	rs1990023	hCV546489	rs264122	0.9	0.9783
  hCV346713	rs1990023	hCV8932829	rs1116596	0.9	1
  hCV349805	rs4851529	hCV16126066	rs2110564	0.9	0.9329
  hCV349805	rs4851529	hCV2676440	rs6722640	0.9	0.9329
  hCV349805	rs4851529	hCV27872026	rs4851531	0.9	0.9646
  hCV349805	rs4851529	hCV8905894	rs974950	0.9	0.9303
  hCV364260	rs2505039	hCV29557190	rs9487275	0.9	0.9632
  hCV364260	rs2505039	hCV35209	rs4329143	0.9	0.9615
  hCV364260	rs2505039	hCV364258	rs2505038	0.9	0.9806
  hCV364260	rs2505039	hCV364261	rs7749240	0.9	0.9639
  hCV375090	rs4450660	hCV26135665	rs4390811	0.9	0.96
  hCV375090	rs4450660	hCV26771384	rs10865197	0.9	1
  hCV375090	rs4450660	hCV26771389	rs10183431	0.9	1
  hCV375090	rs4450660	hCV27875215	rs4346434	0.9	0.922
  hCV375090	rs4450660	hCV27933339	rs4586678	0.9	1
  hCV375090	rs4450660	hCV29229284	rs6741066	0.9	0.9591
  hCV375090	rs4450660	hCV30817981	rs6723119	0.9	0.96
  hCV375090	rs4450660	hCV375079	rs9309112	0.9	0.92
  hCV375090	rs4450660	hCV375083	rs10206724	0.9	1
  hCV375090	rs4450660	hCV514334	rs6544721	0.9	0.961
  hCV443083	rs6742894	hCV48381	rs6743092	0.9	1
  hCV443083	rs6742894	hCV48382	rs12465349	0.9	1
  hCV48381	rs6743092	hCV443083	rs6742894	0.9	1
  hCV48381	rs6743092	hCV48382	rs12465349	0.9	1
  hCV514334	rs6544721	hCV25642662	rs10190161	0.9	0.9211
  hCV514334	rs6544721	hCV26135665	rs4390811	0.9	0.9201
  hCV514334	rs6544721	hCV26771384	rs10865197	0.9	0.961
  hCV514334	rs6544721	hCV26771389	rs10183431	0.9	0.961
  hCV514334	rs6544721	hCV27933339	rs4586678	0.9	0.961
  hCV514334	rs6544721	hCV29229284	rs6741066	0.9	0.9183
  hCV514334	rs6544721	hCV30817981	rs6723119	0.9	1
  hCV514334	rs6544721	hCV375083	rs10206724	0.9	0.96
  hCV514334	rs6544721	hCV375090	rs4450660	0.9	0.961
  hCV546489	rs264122	hCV11819780	rs12153185	0.9	0.9573
  hCV546489	rs264122	hCV11819782	rs12719415	0.9	0.9616
  hCV546489	rs264122	hCV2575318	rs7711358	0.9	0.9616
  hCV546489	rs264122	hCV2575336	rs2418541	0.9	0.9616
  hCV546489	rs264122	hCV2575340	rs11242020	0.9	0.9616
  hCV546489	rs264122	hCV26478744	rs2016194	0.9	0.9581
  hCV546489	rs264122	hCV26478745	rs2108426	0.9	1
  hCV546489	rs264122	hCV26478747	rs2190598	0.9	0.96
  hCV546489	rs264122	hCV26478763	rs2418542	0.9	0.9616
  hCV546489	rs264122	hCV27996154	rs4836502	0.9	0.9616
  hCV546489	rs264122	hCV2961244	rs2418548	0.9	0.9573
  hCV546489	rs264122	hCV2961250	rs4836507	0.9	0.9616
  hCV546489	rs264122	hCV2961252	rs10067895	0.9	0.9616
  hCV546489	rs264122	hCV2961253	rs2190600	0.9	0.9616
  hCV546489	rs264122	hCV2961259	rs11242023	0.9	0.9573
  hCV546489	rs264122	hCV2961260	rs11242022	0.9	0.9783
  hCV546489	rs264122	hCV2961261	rs11242021	0.9	0.9608
  hCV546489	rs264122	hCV2961267	rs1476714	0.9	0.9587
  hCV546489	rs264122	hCV2961268	rs2108425	0.9	0.9616
  hCV546489	rs264122	hCV2961269	rs2158958	0.9	0.9616
  hCV546489	rs264122	hCV2961270	rs9327555	0.9	0.9616
  hCV546489	rs264122	hCV2961278	rs7446891	0.9	0.9616
  hCV546489	rs264122	hCV2961280	rs10520072	0.9	0.9616
  hCV546489	rs264122	hCV2961282	rs917295	0.9	0.9616
  hCV546489	rs264122	hCV2961284	rs10054055	0.9	1
  hCV546489	rs264122	hCV2961296	rs10051148	0.9	1
  hCV546489	rs264122	hCV2961297	rs2158961	0.9	1
  hCV546489	rs264122	hCV2961306	rs264129	0.9	0.9783
  hCV546489	rs264122	hCV29666186	rs6871041	0.9	0.9189
  hCV546489	rs264122	hCV30621656	rs10478919	0.9	0.9616
  hCV546489	rs264122	hCV31237567	rs11749272	0.9	0.9616
  hCV546489	rs264122	hCV346713	rs1990023	0.9	0.9783
  hCV546489	rs264122	hCV8932829	rs1116596	0.9	0.9616
  hCV546493	rs264126	hCV2575337	rs2214640	0.9	1
  hCV546493	rs264126	hCV2575344	rs10064779	0.9	0.9328
  hCV546493	rs264126	hCV26478748	rs2190597	0.9	0.9328
  hCV546493	rs264126	hCV29134277	rs6595948	0.9	0.9001
  hCV546493	rs264126	hCV2961235	rs6869219	0.9	0.9255
  hCV546493	rs264126	hCV2961239	rs6868888	0.9	0.9282
  hCV546493	rs264126	hCV2961251	rs1157409	0.9	0.9328
  hCV546493	rs264126	hCV8932783	rs1473132	0.9	0.9328
  hCV767324	rs687047	hCV1056543	rs688358	0.9	1
  hCV767324	rs687047	hCV1056544	rs675163	0.9	1
  hCV767324	rs687047	hCV32014843	rs11221075	0.9	1
  hCV767324	rs687047	hCV32014853	rs11221097	0.9	1
  hCV8351640	rs842796	hCV9110432	rs12025826	0.9	0.9273
  hCV8375036	rs9960	hCV1166092	rs12406279	0.9	1
  hCV8375036	rs9960	hCV1166096	rs12406643	0.9	1
  hCV8375036	rs9960	hDV70946874	rs17386162	0.9	1
  hCV8375364	rs966583	hCV26441140	rs9325191	0.9	1
  hCV8375364	rs966583	hCV2690333	rs11178602	0.9	1
  hCV8375364	rs966583	hCV2690348	rs11178594	0.9	1
  hCV8375364	rs966583	hCV2690350	rs2132242	0.9	1
  hCV8375364	rs966583	hCV2690354	rs11178589	0.9	1
  hCV8375364	rs966583	hCV2690362	rs10879249	0.9	1
  hCV8375364	rs966583	hCV2690365	rs11178583	0.9	1
  hCV8375364	rs966583	hCV2690375	rs1567740	0.9	1
  hCV8375364	rs966583	hCV2690377	rs10879245	0.9	1
  hCV8375364	rs966583	hCV2690378	rs11178579	0.9	1
  hCV8375364	rs966583	hCV2690379	rs10879242	0.9	1
  hCV8375364	rs966583	hCV2690380	rs10506623	0.9	1
  hCV8375364	rs966583	hCV2690388	rs2132241	0.9	1
  hCV8375364	rs966583	hCV31190567	rs7311994	0.9	1
  hCV8375364	rs966583	hCV31190598	rs12818936	0.9	1
  hCV8375364	rs966583	hCV8871988	rs1495375	0.9	1
  hCV8375364	rs966583	hCV8871989	rs1512989	0.9	1
  hCV8375364	rs966583	hCV8871990	rs1512988	0.9	1
  hCV8375364	rs966583	hCV8873466	rs1051344	0.9	1
  hCV8375364	rs966583	hCV8873472	rs1355373	0.9	1
  hCV8719512	rs4773	hCV8719513	rs1266483	0.9	0.9781
  hCV8719512	rs4773	hCV8719628	rs1266489	0.9	1
  hCV8719628	rs1266489	hCV12100073	rs871078	0.9	0.9543
  hCV8719628	rs1266489	hCV27008723	rs2677744	0.9	0.955
  hCV8719628	rs1266489	hCV2979204	rs734252	0.9	1
  hCV8719628	rs1266489	hCV8718176	rs1550636	0.9	0.955
  hCV8719628	rs1266489	hCV8719512	rs4773	0.9	1
  hCV8719628	rs1266489	hCV8719513	rs1266483	0.9	1
  hCV8793528	rs9857	hCV1973774	rs1483301	0.9	1
  hCV8873448	rs3844207	hCV2690291	rs2270588	0.9	1
  hCV8873448	rs3844207	hCV2690292	rs2270589	0.9	0.9298
  hCV8905894	rs974950	hCV16126066	rs2110564	0.9	1
  hCV8905894	rs974950	hCV2676440	rs6722640	0.9	1
  hCV8905894	rs974950	hCV27872026	rs4851531	0.9	0.9812
  hCV8905894	rs974950	hCV349805	rs4851529	0.9	0.9303
  hCV8932829	rs1116596	hCV11819780	rs12153185	0.9	0.9232
  hCV8932829	rs1116596	hCV11819782	rs12719415	0.9	0.927
  hCV8932829	rs1116596	hCV2575318	rs7711358	0.9	1
  hCV8932829	rs1116596	hCV2575336	rs2418541	0.9	1
  hCV8932829	rs1116596	hCV2575340	rs11242020	0.9	1
  hCV8932829	rs1116596	hCV26478747	rs2190598	0.9	0.9239
  hCV8932829	rs1116596	hCV26478763	rs2418542	0.9	1
  hCV8932829	rs1116596	hCV27996154	rs4836502	0.9	0.927
  hCV8932829	rs1116596	hCV2961244	rs2418548	0.9	0.9232
  hCV8932829	rs1116596	hCV2961250	rs4836507	0.9	0.927
  hCV8932829	rs1116596	hCV2961252	rs10067895	0.9	0.927
  hCV8932829	rs1116596	hCV2961253	rs2190600	0.9	0.927
  hCV8932829	rs1116596	hCV2961260	rs11242022	0.9	0.9232
  hCV8932829	rs1116596	hCV2961261	rs11242021	0.9	0.9255
  hCV8932829	rs1116596	hCV2961267	rs1476714	0.9	0.9607
  hCV8932829	rs1116596	hCV2961268	rs2108425	0.9	0.927
  hCV8932829	rs1116596	hCV2961269	rs2158958	0.9	0.927
  hCV8932829	rs1116596	hCV2961270	rs9327555	0.9	0.927
  hCV8932829	rs1116596	hCV2961278	rs7446891	0.9	0.927
  hCV8932829	rs1116596	hCV2961280	rs10520072	0.9	0.927
  hCV8932829	rs1116596	hCV2961282	rs917295	0.9	0.927
  hCV8932829	rs1116596	hCV2961284	rs10054055	0.9	0.9616
  hCV8932829	rs1116596	hCV2961296	rs10051148	0.9	0.9623
  hCV8932829	rs1116596	hCV2961297	rs2158961	0.9	0.9634
  hCV8932829	rs1116596	hCV2961306	rs264129	0.9	0.9232
  hCV8932829	rs1116596	hCV30621656	rs10478919	0.9	1
  hCV8932829	rs1116596	hCV31237567	rs11749272	0.9	1
  hCV8932829	rs1116596	hCV346713	rs1990023	0.9	1
  hCV8932829	rs1116596	hCV546489	rs264122	0.9	0.9616
  hCV9110432	rs12025826	hCV8351640	rs842796	0.9	0.9273
  hCV940416	rs498657	hCV3125582	rs2243708	0.9	1
  hDV70820190	rs17035071	hDV70820183	rs17035064	0.9	1
  hDV70820190	rs17035071	hDV70820188	rs17035069	0.9	1
  hDV70936275	rs17310169	hDV70936277	rs17310176	0.9	1
  hDV70936277	rs17310176	hDV70936275	rs17310169	0.9	1
  hDV70985165	rs17662322	hDV70995198	rs17718867	0.9	1
  hDV70995198	rs17718867	hDV70985165	rs17662322	0.9	1
  hDV72015086	rs7956274	hCV11686367	rs7955901	0.9	1
  hDV72015086	rs7956274	hCV171102	rs7313973	0.9	0.9584
  hDV72015086	rs7956274	hCV240133	rs4760895	0.9	0.9649
  hDV72015086	rs7956274	hCV240134	rs7138300	0.9	0.9622
  hDV72015086	rs7956274	hCV2745800	rs11178531	0.9	0.9261
  hDV72015086	rs7956274	hCV2745805	rs7132840	0.9	0.9261
  hDV72015086	rs7956274	hCV2745815	rs1512991	0.9	1
  hDV72015086	rs7956274	hCV2745822	rs1913201	0.9	0.9622
  hDV72015086	rs7956274	hCV2745828	rs10879240	0.9	0.9285
  hDV72015086	rs7956274	hCV27952502	rs4760894	0.9	0.9649
  hDV72015086	rs7956274	hCV27952503	rs4760785	0.9	0.9649
  hDV72015086	rs7956274	hCV29120310	rs7298255	0.9	1
  hDV72015086	rs7956274	hCV31190748	rs7959965	0.9	1
  hDV72015086	rs7956274	hCV31190777	rs10784891	0.9	1
  hDV76981734	rs4251569	hCV27943699	rs4238087	0.9	1

• TABLE 4
  	al-
  	lele	al-

  A1

  lele

  Meta-analysis

  CARE

  WOSCOPS

  (non-

  A2

  OR

  OR

  P

  Prava

  Placebo

  OR

  OR

  Prava

  Placebo

  OR

  OR

  Mod-

  End-

  Marker

  ref)

  (ref)

  OR

  L95

  U95

  value

  Count

  Count

  OR

  L95

  U95

  P value

  Source

  Count

  Count

  OR

  L95

  U95

  P value

  Source

  el

  point

  rs2157673	G	A	1.50	1.26	1.78	5.54E−	50/156/151	28/189/	1.47	1.18	1.82	5.43E−04	Case-	24/85/75	19/93/135	1.56	1.16	2.09	2.99E−03	Caseonly	add	CVD
  						06		227					only
  rs12155847	G	A	1.66	1.32	2.09	1.80E−	47/174/136	45/173/226	1.69	1.27	2.24	3.58E−04	Case-	18/90/76	19/99/129	1.61	1.09	2.37	1.71E−02	Caseonly	dom	CVD
  						05							only
  rs9292827	A	G	0.34	0.20	0.56	3.46E−	1/14/342	1/47/395	0.37	0.20	0.67	1.08E−03	Case-	2/3/179	1/22/224	0.27	0.10	0.73	9.50E−03	Caseonly	dom	CVD
  						05							only
  rs2695026	A	G	0.67	0.55	0.81	3.85E−	18/116/221	43/164/236	0.70	0.55	0.88	2.23E−03	Case-	5/52/124	16/92/137	0.61	0.43	0.86	4.67E−03	Caseonly	add	CVD
  						05							only
  rs205279	A	G	1.81	1.36	2.41	4.59E−	5/78/274	2/61/381	1.94	1.36	2.76	2.54E−04	Case-	0/43/141	0/39/208	1.60	0.99	2.60	5.76E−02	Caseonly	add	CVD
  						05							only
  rs17706237	G	A	1.69	1.31	2.19	5.77E−	13/111/176	13/94/275	1.80	1.31	2.49	3.42E−04	Case-	7/61/91	9/65/150	1.52	1.00	2.31	5.28E−02	CaseOnly	dom	CHD
  						05							Only
  rs10120126	G	A	0.51	0.37	0.71	5.98E−	4/43/253	11/87/284	0.53	0.36	0.78	1.55E−03	Case-	3/16/139	5/44/175	0.48	0.27	0.86	1.30E−02	CaseOnly	dom	CHD
  						05							Only
  rs1948	A	G	1.66	1.29	2.13	6.47E−	40/134/126	38/146/198	1.52	1.12	2.07	7.49E−03	Case-	19/88/52	27/88/109	1.96	1.29	3.00	1.83E−03	CaseOnly	dom	CHD
  						05							Only
  rs10088505	A	G	1.61	1.27	2.03	6.58E−	38/180/139	51/177/215	1.52	1.14	2.03	4.28E−03	Case-	24/87/70	23/93/127	1.78	1.20	2.63	4.27E−03	Caseonly	dom	CVD
  						05							only
  rs354342	A	G	0.67	0.55	0.82	6.82E−	17/115/225	37/171/236	0.70	0.55	0.89	3.07E−03	Case-	5/51/128	15/90/142	0.62	0.44	0.87	6.35E−03	Caseonly	add	CVD
  						05							only
  rs1035618	A	C	1.42	1.19	1.68	6.96E−	45/169/140	39/181/219	1.38	1.12	1.71	2.98E−03	Case-	31/86/66	23/111/	1.48	1.11	1.98	7.61E−03	Caseonly	add	CVD
  						05							only		111
  rs238272	A	G	1.45	1.21	1.74	7.57E−	35/139/126	28/149/205	1.44	1.14	1.82	2.44E−03	Case-	32/64/63	22/94/108	1.46	1.09	1.96	1.07E−02	CaseOnly	add	CHD
  						05							Only
  rs10849442	A	G	0.57	0.43	0.75	8.56E−	57/207/93	112/220/	0.56	0.39	0.80	1.36E−03	Case-	37/100/	73/100/74	0.59	0.37	0.93	2.26E−02	Caseonly	rec	CVD
  						05		112					only	46
  rs2376764	A	G	0.56	0.41	0.74	8.56E−	55/185/117	103/220/	0.61	0.42	0.88	8.65E−03	Case-	30/99/55	71/117/58	0.48	0.29	0.77	2.46E−03	Caseonly	rec	CVD
  						05		121					only
  rs2273816	A	G	1.61	1.27	2.05	8.70E−	9/87/204	5/81/296	1.56	1.15	2.12	4.66E−03	Case-	10/46/103	5/49/170	1.69	1.16	2.47	6.17E−03	CaseOnly	add	CHD
  						05							Only
  rs2941528	A	G	0.67	0.54	0.82	1.79E−	13/111/176	29/162/191	0.72	0.56	0.93	1.31E−02	Case-	12/50/96	21/112/91	0.58	0.41	0.81	1.38E−03	CaseOnly	add	CHD
  						04							Only
  rs1615197	G	A	1.80	1.25	2.60	1.71E−	56/146/98	61/158/163	1.54	1.12	2.11	7.76E−03	Case-	38/81/40	28/98/98	2.25	1.44	3.52	3.75E−04	CaseOnly	dom	CHD
  						03							Only
  rs1349282	A	G	0.55	0.44	0.69	3.97E−	254/731/	290/709/	0.55	0.41	0.74	1.05E−04	cohort	459/1274/	469/1271/	0.55	0.38	0.79	1.10E−03	cohort	dom	CVD
  						07	509	472						924	918
  rs4986146	A	G	0.63	0.53	0.76	4.36E−	109/579/807	89/562/818	0.62	0.49	0.77	2.63E−05	cohort	175/1031/	181/1039/	0.66	0.50	0.88	4.63E−03	cohort	add	CVD
  						07								1436	1427
  rs3213616	A	G	0.62	0.51	0.76	2.68E−	74/479/933	75/465/920	0.62	0.49	0.80	1.60E−04	cohort	77/807/	79/852/	0.62	0.45	0.87	5.26E−03	cohort	add	CVD
  						06								1767	1727
  rs2008165	G	A	0.59	0.47	0.73	2.77E−	650/115/728	676/99/695	0.57	0.43	0.76	1.06E−04	cohort	1301/6/	1261/4/	0.62	0.43	0.89	9.37E−03	cohort	add	CHD
  						06								1343	1393
  rs10500736	G	A	0.57	0.45	0.72	2.82E−	254/1214/	130/603/	0.61	0.45	0.83	1.62E−03	cohort	230/1135/	256/1109/	0.52	0.36	0.75	4.18E−04	cohort	dom	CHD
  						06	1417	700						1290	1296
  rs7705993	G	A	1.48	1.24	1.76	9.34E−	370/724/	333/755/	1.50	1.21	1.85	1.98E−04	cohort	44/77/38	38/117/69	1.44	1.07	1.94	1.57E−02	CaseOnly	add	CHD
  						06	401	382
  rs12556591	G	A	0.59	0.47	0.75	1.04E−	625/114/	665/95/	0.57	0.43	0.75	7.93E−05	cohort	66/0/93	115/0/109	0.66	0.44	1.00	4.88E−02	CaseOnly	add	CHD
  						05	755	710
  rs2534752	G	A	1.65	1.32	2.07	1.17E−	63/485/947	51/467/951	1.60	1.19	2.15	1.67E−03	cohort	112/890/	129/915/	1.74	1.22	2.47	2.10E−03	cohort	dom	CVD
  						05								1649	1613
  rs4830819	G	A	0.60	0.48	0.75	1.36E−	641/113/	673/97/699	0.57	0.43	0.76	8.61E−05	cohort	66/0/93	115/0/109	0.66	0.44	1.00	4.88E−02	CaseOnly	add	CHD
  						05	740
  rs10189905	C	A	0.52	0.39	0.70	1.52E−	12/256/	13/281/	0.50	0.34	0.73	3.92E−04	cohort	15/496/	30/434/	0.56	0.36	0.88	1.21E−02	cohort	add	CHD
  						05	1227	1177						2143	2195
  rs316720	G	A	0.71	0.61	0.83	2.28E−	223/758/	265/690/	0.67	0.55	0.82	1.19E−04	cohort	531/1320/	540/1301/	0.78	0.61	1.00	4.57E−02	cohort	add	CVD
  						05	514	516						796	814
  rs3998860	A	G	0.61	0.49	0.77	2.29E−	129/851/	75/416/941	0.58	0.44	0.76	7.97E−05	cohort	3/44/112	6/80/138	0.70	0.47	1.05	8.17E−02	CaseOnly	add	CHD
  						05	1903
  rs3732788	G	A	0.51	0.38	0.70	2.57E−	16/212/	14/275/	0.56	0.38	0.81	2.46E−03	cohort	0/21/138	3/53/168	0.44	0.26	0.75	2.64E−03	CaseOnly	add	CHD
  						05	1267	1180
  rs669684	G	A	0.72	0.62	0.84	2.85E−	260/758/	309/690/	0.69	0.56	0.84	2.75E−04	cohort	633/1333/	626/1318/	0.77	0.60	0.97	3.00E−02	cohort	add	CVD
  						05	476	472						689	715
  rs2418412	G	A	1.94	1.42	2.65	3.05E−	270/722/	272/703/	2.20	1.48	3.25	8.63E−05	cohort	450/1353/	454/1264/	1.58	0.96	2.62	7.27E−02	cohort	rec	CHD
  						05	502	494						847	942
  rs13279522	G	A	0.62	0.50	0.78	3.67E−	51/391/	51/438/981	0.62	0.47	0.83	1.13E−03	cohort	73/693/	57/696/	0.63	0.44	0.90	1.12E−02	cohort	add	CHD
  						05	1053							1889	1911
  rs7193741	A	C	2.04	1.45	2.86	3.91E−	233/716/	212/700/	2.16	1.39	3.36	6.33E−04	cohort	368/1263/	372/1225/	1.87	1.10	3.18	2.01E−02	cohort	rec	CHD
  						05	546	559						1022	1064
  rs151806	G	A	0.63	0.50	0.78	4.01E−	78/545/871	75/578/	0.60	0.45	0.80	4.38E−04	cohort	142/909/	124/918/	0.67	0.47	0.96	2.92E−02	cohort	dom	CVD
  						05		816						1597	1611
  rs9446187	A	G	1.96	1.42	2.72	4.36E−	19/268/	16/238/	1.92	1.28	2.87	1.53E−03	cohort	11/338/	8/305/	2.05	1.19	3.53	9.61E−03	cohort	dom	CHD
  						05	1208	1217						2307	2347
  rs2793086	C	A	0.65	0.53	0.80	4.71E−	53/498/944	55/441/975	0.61	0.47	0.80	2.19E−04	cohort	3/56/125	11/85/151	0.72	0.50	1.02	6.63E−02	Caseonly	add	CVD
  						05
  rs17076974	A	G	1.40	1.19	1.65	5.58E−	361/727/	323/756/	1.46	1.18	1.81	4.91E−04	cohort	594/1320/	578/1344/	1.32	1.02	1.71	3.48E−02	cohort	add	CHD
  						05	405	392						729	726
  rs4924215	A	G	1.65	1.29	2.11	5.58E−	215/1214/	106/594/	1.77	1.30	2.39	2.41E−04	cohort	12/67/80	19/71/134	1.46	0.97	2.21	6.97E−02	CaseOnly	dom	CHD
  						05	1535	769
  rs1884897	A	G	2.07	1.45	2.95	5.65E−	214/702/	192/687/	2.24	1.45	3.46	2.93E−04	cohort	26/73/60	22/116/86	1.78	0.97	3.29	6.31E−02	CaseOnly	rec	CHD
  						05	578	591
  rs610118	G	A	0.49	0.34	0.69	5.81E−	24/201/	15/201/	0.43	0.28	0.66	1.35E−04	cohort	1/18/165	1/37/209	0.62	0.34	1.12	1.10E−01	Caseonly	dom	CVD
  						05	1269	1253
  rs7179134	A	G	3.52	1.90	6.52	6.11E−	67/464/	64/466/941	3.54	1.54	8.15	2.91E−03	cohort	102/858/	109/872/	3.50	1.40	8.72	7.28E−03	cohort	rec	CVD
  						05	964							1693	1674
  rs4993917	A	C	0.60	0.47	0.77	6.48E−	322/746/	320/722/	0.57	0.42	0.77	3.33E−04	cohort	37/89/58	52/136/59	0.67	0.43	1.03	6.44E−02	Caseonly	dom	CVD
  						05	427	429
  rs7671659	A	G	1.60	1.27	2.02	6.68E−	59/427/	58/430/983	1.72	1.28	2.32	3.19E−04	cohort	81/726/	59/733/	1.43	0.99	2.07	5.96E−02	cohort	dom	CVD
  						05	1009							1845	1863
  rs10889215	A	G	1.63	1.28	2.06	6.72E−	35/297/	30/280/	1.50	1.13	1.99	5.01E−03	cohort	30/407/	21/395/	1.95	1.27	3.00	2.22E−03	cohort	add	CVD
  						05	1162	1158						2217	2247
  rs9487284	A	G	0.64	0.52	0.80	6.85E−	212/634/	163/669/	0.61	0.46	0.80	4.52E−04	cohort	293/1216/	335/1259/	0.70	0.50	0.99	4.62E−02	cohort	dom	CVD
  						05	648	637						1142	1063
  rs7742508	A	G	2.08	1.45	2.99	6.86E−	13/205/	6/192/1272	2.19	1.37	3.49	9.74E−04	cohort	0/296/	0/257/	1.93	1.09	3.43	2.42E−02	cohort	dom	CVD
  						05	1277							2357	2401
  rs2492367	A	G	0.61	0.47	0.78	7.23E−	16/325/	17/307/	0.56	0.40	0.77	4.19E−04	cohort	44/578/	42/585/	0.68	0.46	1.00	4.80E−02	cohort	add	CVD
  						05	1153	1146						2033	2033
  rs10429616	G	A	1.85	1.36	2.50	7.30E−	276/736/	282/699/	2.07	1.41	3.04	2.21E−04	cohort	481/1361/	479/1282/	1.54	0.94	2.51	8.52E−02	cohort	rec	CHD
  						05	481	488						815	901
  rs2069542	A	G	1.62	1.28	2.05	7.35E−	103/802/	44/398/	1.67	1.26	2.22	3.45E−04	cohort	1/49/109	1/51/172	1.49	0.96	2.32	7.85E−02	CaseOnly	add	CHD
  						05	2061	1029
  rs10155047	A	G	0.55	0.41	0.74	7.66E−	18/215/	15/273/	0.59	0.40	0.85	5.11E−03	cohort	18/437/	30/467/	0.50	0.31	0.80	4.45E−03	cohort	add	CHD
  						05	1262	1183						2201	2163
  rs4626316	A	G	0.35	0.21	0.59	8.00E−	10/94/	13/98/	0.34	0.18	0.64	7.09E−04	cohort	3/118/	3/111/	0.38	0.15	0.97	4.23E−02	cohort	dom	CVD
  						05	1388	1358						2537	2547
  rs17138705	A	G	0.59	0.45	0.77	8.17E−	25/336/	36/343/	0.54	0.39	0.74	1.78E−04	cohort	0/32/127	6/51/167	0.70	0.44	1.11	1.28E−01	CaseOnly	add	CHD
  						05	1134	1092
  rs10494924	C	A	0.64	0.51	0.80	9.70E−	143/606/	141/639/	0.61	0.46	0.81	6.69E−04	cohort	19/65/	22/115/	0.68	0.46	1.00	5.11E−02	Caseonly	dom	CVD
  						05	744	690						100	110
  rs33910446	A	G	2.24	1.49	3.36	1.02E−	128/573/	107/558/	2.24	1.34	3.75	1.99E−03	cohort	24/74/85	16/113/	2.23	1.14	4.34	1.87E−02	Caseonly	rec	CVD
  						04	791	804							118
  rs1051344	G	C	0.64	0.51	0.80	1.07E−	262/694/	253/734/	0.64	0.48	0.86	2.62E−03	cohort	431/1243/	416/1234/	0.64	0.45	0.92	1.47E−02	cohort	dom	CVD
  						04	537	484						981	1008
  rs10444402	G	A	0.69	0.57	0.83	1.16E−	74/522/	102/500/	0.71	0.57	0.89	3.33E−03	cohort	7/62/115	18/103/	0.65	0.47	0.91	1.12E−02	Caseonly	add	CVD
  						04	899	868							126
  rs7612715	A	G	0.50	0.35	0.71	1.21E−	18/161/	8/160/1303	0.47	0.30	0.73	9.43E−04	cohort	6/242/	12/257/	0.55	0.31	0.99	4.49E−02	cohort	add	CVD
  						04	1316							2408	2393
  rs4243071	G	A	0.43	0.28	0.66	1.22E−	274/1165/	143/535/	0.44	0.26	0.76	2.80E−03	cohort	11/76/97	32/91/124	0.41	0.20	0.85	1.56E−02	Caseonly	rec	CVD
  						04	1527	793
  rs624460	A	G	0.73	0.63	0.86	1.24E−	208/651/	216/667/	0.73	0.60	0.90	2.54E−03	cohort	350/1250/	389/1245/	0.74	0.57	0.95	1.78E−02	cohort	add	CVD
  						04	635	588						1054	1022
  rs4866354	G	A	0.35	0.20	0.59	1.25E−	0/102/1392	0/107/1363	0.36	0.19	0.67	1.19E−03	cohort	0/4/180	0/16/231	0.31	0.10	0.94	3.92E−02	Caseonly	dom	CVD
  						04
  rs945020	A	G	0.65	0.52	0.81	1.33E−	390/1333/	203/669/	0.61	0.45	0.81	6.95E−04	cohort	385/1221/	395/1260/	0.72	0.51	1.01	5.77E−02	cohort	dom	CVD
  						04	1162	561						1049	1003
  rs9859901	A	C	0.52	0.38	0.73	1.37E−	17/214/1264	16/270/1185	0.59	0.41	0.86	5.91E−03	cohort	0/20/139	3/53/168	0.41	0.24	0.72	1.59E−03	CaseOnly	add	CHD
  						04
  rs7629632	G	A	1.62	1.26	2.07	1.38E−	171/687/637	169/638/664	1.56	1.15	2.12	4.23E−03	cohort	15/83/60	22/87/115	1.72	1.13	2.60	1.10E−02	CaseOnly	dom	CHD
  						04
  rs17740227	G	A	1.70	1.29	2.23	1.45E−	21/306/1166	21/295/1155	1.80	1.28	2.53	6.94E−04	cohort	0/48/136	2/45/200	1.53	0.96	2.42	7.13E−02	Caseonly	dom	CVD
  						04
  rs2263920	G	A	0.46	0.31	0.69	1.45E−	197/704/593	207/668/596	0.49	0.30	0.79	3.40E−03	cohort	11/71/77	36/100/88	0.41	0.20	0.84	1.42E−02	CaseOnly	rec	CHD
  						04
  rs1538185	A	G	1.60	1.26	2.05	1.51E−	69/499/927	52/432/987	1.75	1.28	2.41	5.47E−04	cohort	101/868/	109/864/	1.41	0.96	2.07	7.60E−02	cohort	dom	CHD
  						04								1686	1680
  rs2843171	A	G	0.64	0.51	0.81	1.54E−	103/585/806	124/584/761	0.67	0.50	0.88	4.44E−03	cohort	15/58/111	20/109/	0.61	0.41	0.89	1.16E−02	Caseonly	dom	CVD
  						04									118
  rs4726711	G	A	0.71	0.59	0.85	1.61E−	217/674/604	197/712/562	0.75	0.60	0.94	1.19E−02	cohort	15/62/82	33/109/82	0.62	0.45	0.85	2.88E−03	CaseOnly	add	CHD
  						04
  rs2263901	G	A	1.48	1.21	1.81	1.63E−	84/533/876	61/508/899	1.43	1.11	1.84	5.41E−03	cohort	11/62/86	10/62/152	1.57	1.12	2.21	9.90E−03	CaseOnly	add	CHD
  						04
  rs5021480	A	C	1.78	1.32	2.40	1.67E−	544/1410/	254/697/481	1.72	1.18	2.52	4.85E−03	cohort	45/77/62	37/106/	1.87	1.15	3.04	1.21E−02	Caseonly	rec	CVD
  						04	929								104
  rs1877986	A	G	0.62	0.48	0.80	1.73E−	569/1391/	283/699/451	0.57	0.41	0.78	5.70E−04	cohort	494/1321/	518/1314/	0.71	0.48	1.05	8.37E−02	cohort	dom	CHD
  						04	924							831	820
  rs11610993	G	A	0.43	0.28	0.67	1.76E−	6/131/1358	3/140/1328	0.41	0.25	0.69	7.19E−04	cohort	0/8/176	0/20/227	0.49	0.21	1.14	9.82E−02	Caseonly	dom	CVD
  						04
  rs1864924	G	A	1.40	1.17	1.67	1.78E−	210/620/664	192/652/627	1.42	1.15	1.77	1.40E−03	cohort	28/68/63	19/106/99	1.36	1.00	1.84	4.79E−02	CaseOnly	add	CHD
  						04
  rs17347854	G	A	0.61	0.48	0.79	1.79E−	40/356/1099	38/404/1028	0.61	0.44	0.84	2.13E−03	cohort	3/41/140	13/70/164	0.62	0.41	0.96	3.17E−02	Caseonly	dom	CVD
  						04
  rs13137776	G	A	0.70	0.58	0.84	1.83E−	148/636/711	158/661/652	0.74	0.59	0.94	1.18E−02	cohort	11/47/101	27/86/111	0.62	0.45	0.86	3.72E−03	CaseOnly	add	CHD
  						04
  rs3759607	G	A	1.96	1.38	2.78	1.90E−	4/209/1281	4/165/1302	2.10	1.35	3.28	1.06E−03	cohort	0/29/130	2/24/198	1.73	0.97	3.09	6.18E−02	CaseOnly	dom	CHD
  						04
  rs9896077	G	A	0.66	0.53	0.82	2.07E−	209/677/608	196/699/576	0.63	0.47	0.83	1.35E−03	cohort	353/1151/	406/1253/	0.71	0.50	1.00	5.20E−02	cohort	dom	CVD
  						04								1146	996
  rs10935907	G	A	1.59	1.24	2.03	2.12E−	112/544/838	80/535/856	1.65	1.21	2.23	1.37E−03	cohort	5/74/80	17/72/135	1.49	0.99	2.25	5.72E−02	CaseOnly	dom	CHD
  						04
  rs7625204	A	G	1.45	1.19	1.77	2.24E−	119/980/	52/488/931	1.51	1.16	1.96	2.11E−03	cohort	131/897/	118/925/	1.38	1.02	1.87	3.67E−02	cohort	add	CHD
  						04	1866							1628	1616
  rs13431868	A	G	1.59	1.24	2.03	2.24E−	82/554/857	71/538/860	1.70	1.25	2.31	7.44E−04	cohort	8/68/83	10/77/137	1.42	0.94	2.14	9.94E−02	CaseOnly	dom	CHD
  						04
  rs2231496	G	A	0.72	0.60	0.86	2.27E−	133/622/740	140/618/713	0.74	0.60	0.92	6.39E−03	cohort	8/73/103	26/107/	0.67	0.49	0.91	1.13E−02	Caseonly	add	CVD
  						04									114
  rs1705244	G	A	0.60	0.46	0.79	2.28E−	650/1518/	307/782/382	0.65	0.46	0.91	1.20E−02	cohort	37/65/57	52/123/49	0.52	0.33	0.82	5.01E−03	CaseOnly	dom	CHD
  						04	798
  rs2274473	G	A	0.55	0.40	0.75	2.28E−	27/264/1202	26/297/1147	0.58	0.39	0.85	5.84E−03	cohort	2/17/140	3/46/175	0.48	0.27	0.85	1.21E−02	CaseOnly	dom	CHD
  						04
  rs5750116	G	A	1.55	1.23	1.97	2.28E−	139/685/671	129/641/701	1.63	1.20	2.22	1.69E−03	cohort	296/1113/	232/1174/	1.45	1.01	2.09	4.63E−02	cohort	dom	CHD
  						04								1245	1254
  rs912366	G	A	1.66	1.27	2.18	2.29E−	31/393/1071	21/357/1093	1.60	1.14	2.24	6.82E−03	cohort	6/50/103	7/45/172	1.79	1.14	2.81	1.13E−02	CaseOnly	dom	CHD
  						04
  rs1544214	A	G	1.38	1.16	1.64	2.36E−	461/1344/	212/678/543	1.40	1.13	1.74	2.38E−03	cohort	42/66/51	37/102/85	1.35	1.02	1.78	3.72E−02	CaseOnly	add	CHD
  						04	1080
  rs1861326	A	G	0.64	0.51	0.82	2.44E−	226/692/577	238/710/521	0.63	0.47	0.85	1.90E−03	cohort	28/84/72	32/141/74	0.67	0.45	1.00	4.96E−02	Caseonly	dom	CVD
  						04
  rs2265346	C	A	0.54	0.39	0.75	2.59E−	20/249/1226	20/287/1164	0.60	0.40	0.90	1.27E−02	cohort	2/15/141	3/46/173	0.42	0.23	0.76	4.46E−03	CaseOnly	dom	CHD
  						04
  rs7521242	A	G	0.72	0.61	0.86	2.77E−	630/1424/	326/707/398	0.71	0.57	0.88	2.19E−03	cohort	31/80/48	59/114/51	0.74	0.55	1.00	4.85E−02	CaseOnly	add	CHD
  						04	829
  rs10305439	A	C	0.62	0.48	0.80	2.78E−	245/729/521	269/745/457	0.62	0.45	0.85	2.76E−03	cohort	30/71/58	37/125/60	0.63	0.40	0.98	3.91E−02	CaseOnly	dom	CHD
  						04
  rs1167245	A	G	0.62	0.47	0.80	2.79E−	350/728/417	369/693/408	0.68	0.50	0.92	1.29E−02	cohort	45/78/61	63/134/50	0.51	0.33	0.79	2.73E−03	Caseonly	dom	CVD
  						04
  rs2495295	G	A	0.66	0.52	0.82	2.89E−	136/608/751	143/629/697	0.65	0.49	0.87	3.00E−03	cohort	19/63/102	22/114/	0.66	0.45	0.98	3.73E−02	Caseonly	dom	CVD
  						04									111
  rs312929	G	A	0.75	0.64	0.87	2.96E−	202/704/589	224/698/549	0.72	0.59	0.88	1.71E−03	cohort	350/1243/	406/1240/	0.79	0.61	1.01	6.04E−02	cohort	add	CVD
  						04								1054	1014
  rs969356	G	A	0.63	0.49	0.81	3.10E−	207/675/612	192/716/561	0.69	0.51	0.94	2.00E−02	cohort	15/62/82	31/110/83	0.54	0.36	0.82	3.60E−03	CaseOnly	dom	CHD
  						04
  rs5017584	A	G	1.74	1.29	2.36	3.25E−	279/720/496	245/694/531	1.61	1.10	2.37	1.46E−02	cohort	45/76/63	35/108/	1.98	1.21	3.24	6.65E−03	Caseonly	rec	CVD
  						04									104
  rs6491586	G	A	1.65	1.26	2.18	3.26E−	28/377/1090	21/336/1114	1.59	1.13	2.24	8.26E−03	cohort	6/48/105	6/44/174	1.78	1.13	2.80	1.37E−02	CaseOnly	dom	CHD
  						04
  rs842796	A	G	1.59	1.23	2.05	3.30E−	248/697/550	219/684/568	1.72	1.26	2.37	7.49E−04	cohort	22/80/57	39/88/97	1.38	0.91	2.10	1.35E−01	CaseOnly	dom	CHD
  						04
  rs4869033	G	A	0.36	0.21	0.63	3.53E−	244/1142/	135/569/767	0.31	0.16	0.63	1.20E−03	cohort	7/81/96	18/106/	0.47	0.19	1.15	9.76E−02	Caseonly	rec	CVD
  						04	1580								123
  rs10973013	A	G	0.55	0.40	0.77	3.59E−	21/256/1218	21/297/1153	0.59	0.40	0.88	9.32E−03	cohort	2/17/140	3/46/174	0.48	0.27	0.85	1.16E−02	CaseOnly	dom	CHD
  						04
  rs886469	G	A	0.64	0.50	0.82	3.96E−	199/671/625	184/708/579	0.70	0.51	0.95	2.12E−02	cohort	15/62/82	29/111/84	0.55	0.36	0.83	4.53E−03	CaseOnly	dom	CHD
  						04
  rs11076320	C	A	0.65	0.52	0.83	4.01E−	233/691/568	249/708/512	0.64	0.48	0.86	2.64E−03	cohort	28/85/71	31/141/73	0.68	0.45	1.02	6.00E−02	Caseonly	dom	CVD
  						04
  rs2145540	A	G	0.56	0.40	0.77	4.02E−	18/247/1230	14/282/1175	0.51	0.35	0.75	5.69E−04	cohort	1/18/165	2/32/213	0.70	0.38	1.27	2.37E−01	Caseonly	dom	CVD
  						04
  rs6505669	G	A	1.58	1.22	2.03	4.18E−	59/496/940	52/463/956	1.70	1.24	2.34	9.67E−04	cohort	10/59/90	9/71/144	1.37	0.90	2.09	1.36E−01	CaseOnly	dom	CHD
  						04
  rs9375683	G	A	1.49	1.19	1.87	4.39E−	86/527/882	67/465/939	1.63	1.22	2.18	8.91E−04	cohort	128/942/	132/928/	1.31	0.92	1.86	1.36E−01	cohort	dom	CVD
  						04								1584	1601
  rs10814422	G	A	0.57	0.42	0.78	4.75E−	28/284/1182	30/309/1130	0.64	0.44	0.92	1.72E−02	cohort	2/18/139	3/50/170	0.46	0.26	0.80	6.31E−03	CaseOnly	dom	CHD
  						04
  rs72746987	A	G	0.40	0.24	0.67	4.89E−	3/96/1396	4/139/1328	0.43	0.24	0.80	7.44E−03	cohort	2/4/178	1/21/225	0.34	0.14	0.86	2.29E−02	Caseonly	dom	CVD
  						04
  rs13318232	G	A	0.52	0.36	0.75	5.01E−	17/212/1266	18/264/1189	0.60	0.40	0.90	1.34E−02	cohort	0/20/139	3/54/167	0.40	0.23	0.71	1.55E−03	CaseOnly	dom	CHD
  						04
  rs2268650	A	G	0.66	0.53	0.84	5.28E−	190/697/608	215/695/560	0.64	0.48	0.85	2.27E−03	cohort	29/83/72	31/138/78	0.71	0.47	1.06	9.15E−02	Caseonly	dom	CVD
  						04
  rs4682522	C	A	0.55	0.39	0.77	5.52E−	29/417/2519	18/224/1229	0.59	0.39	0.90	1.55E−02	cohort	0/21/138	1/51/172	0.49	0.28	0.85	1.17E−02	CaseOnly	dom	CHD
  						04
  rs3798544	A	G	1.57	1.21	2.03	5.87E−	32/400/1062	42/342/1087	1.47	1.08	2.02	1.55E−02	cohort	1/55/128	2/46/199	1.78	1.14	2.79	1.12E−02	Caseonly	dom	CVD
  						04
  rs6080603	A	C	0.62	0.47	0.81	5.91E−	93/835/2038	46/443/982	0.59	0.42	0.83	2.06E−03	cohort	4/32/123	7/61/156	0.68	0.43	1.09	1.11E−01	CaseOnly	dom	CHD
  						04
  rs10517923	A	G	1.61	1.23	2.12	5.93E−	352/720/422	311/730/429	1.62	1.16	2.26	4.84E−03	cohort	47/86/49	44/131/71	1.60	1.00	2.55	4.93E−02	Caseonly	rec	CVD
  						04
  rs2104506	A	C	0.71	0.59	0.87	5.99E−	114/593/788	106/608/757	0.75	0.59	0.96	2.07E−02	cohort	15/47/97	23/104/97	0.65	0.47	0.90	8.45E−03	CaseOnly	add	CHD
  						04
  rs2023650	A	G	0.71	0.59	0.87	6.11E−	81/533/878	98/523/846	0.76	0.60	0.96	2.20E−02	cohort	5/53/126	16/91/139	0.62	0.44	0.87	5.84E−03	Caseonly	add	CVD
  						04
  rs8051893	A	G	0.67	0.53	0.84	6.22E−	424/1374/	216/699/555	0.69	0.52	0.92	1.05E−02	cohort	20/81/83	34/128/85	0.63	0.43	0.93	2.13E−02	Caseonly	dom	CVD
  						04	1167
  rs8109631	A	G	1.53	1.20	1.96	6.35E−	119/625/749	109/573/789	1.53	1.13	2.07	6.36E−03	cohort	17/73/69	19/85/120	1.54	1.02	2.32	4.00E−02	CaseOnly	dom	CHD
  						04
  rs331555	A	C	0.74	0.62	0.88	6.42E−	245/1285/	141/632/695	0.72	0.58	0.89	2.91E−03	cohort	12/83/89	31/108/	0.77	0.57	1.04	8.69E−02	Caseonly	add	CVD
  						04	1432								108
  rs1343563	C	A	0.60	0.45	0.81	6.82E−	22/273/1199	23/301/1145	0.61	0.43	0.88	6.99E−03	cohort	1/20/138	3/46/175	0.58	0.34	0.97	3.81E−02	CaseOnly	add	CHD
  						04
  rs11082492	A	C	1.55	1.20	2.00	6.99E−	31/369/1095	27/347/1095	1.46	1.07	1.99	1.65E−02	cohort	4/42/113	1/42/181	1.76	1.13	2.74	1.28E−02	CaseOnly	add	CHD
  						04
  rs17546598	A	G	1.71	1.25	2.33	7.18E−	22/465/2471	10/210/1247	1.57	1.08	2.28	1.91E−02	cohort	1/34/149	0/25/222	2.07	1.19	3.61	1.02E−02	Caseonly	dom	CVD
  						04
  rs1382787	G	A	1.35	1.13	1.61	7.52E−	558/1447/	288/679/504	1.37	1.10	1.69	4.46E−03	cohort	36/85/38	40/113/71	1.32	0.98	1.78	6.95E−02	CaseOnly	add	CHD
  						04	961
  rs6075209	A	G	0.64	0.50	0.83	7.71E−	499/1425/	275/687/509	0.63	0.46	0.86	3.35E−03	cohort	26/75/58	40/123/61	0.68	0.44	1.07	9.33E−02	CaseOnly	dom	CHD
  						04	1042
  rs11925875	A	G	0.66	0.52	0.84	7.79E−	271/707/516	304/700/467	0.72	0.53	0.97	3.13E−02	cohort	26/83/75	48/129/70	0.57	0.38	0.85	6.05E−03	Caseonly	dom	CVD
  						04
  rs13314266	G	A	0.51	0.35	0.76	8.20E−	9/185/1301	11/228/1231	0.60	0.40	0.91	1.49E−02	cohort	0/18/141	3/49/172	0.40	0.23	0.71	1.61E−03	CaseOnly	add	CHD
  						04
  rs3000490	G	A	1.38	1.14	1.66	8.36E−	248/1186/	118/575/778	1.45	1.15	1.83	1.71E−03	cohort	15/72/72	16/91/117	1.25	0.91	1.72	1.72E−01	CaseOnly	add	CHD
  						04	1532
  rs4289236	A	G	1.41	1.15	1.72	8.44E−	68/450/975	74/406/990	1.37	1.08	1.75	1.04E−02	cohort	8/61/115	4/67/176	1.49	1.04	2.13	3.03E−02	Caseonly	add	CVD
  						04
  rs2060411	A	G	1.39	1.15	1.69	8.75E−	228/1159/	97/568/806	1.37	1.07	1.74	1.10E−02	cohort	17/71/71	12/95/117	1.44	1.03	2.00	3.07E−02	CaseOnly	add	CHD
  						04	1579
  rs4643388	G	A	1.34	1.12	1.59	9.82E−	166/639/690	123/628/720	1.32	1.07	1.62	1.06E−02	cohort	20/80/84	16/98/133	1.38	1.02	1.86	3.61E−02	Caseonly	add	CVD
  						04
  rs9436636	A	G	1.35	1.13	1.61	1.02E−	446/1361/	200/680/554	1.34	1.08	1.67	8.75E−03	cohort	27/81/51	28/102/93	1.36	1.00	1.83	4.76E−02	CaseOnly	add	CHD
  						03	1079
  rs7327364	A	G	0.68	0.53	0.85	1.05E−	249/686/560	218/746/507	0.69	0.52	0.93	1.30E−02	cohort	29/81/74	37/136/74	0.64	0.43	0.96	3.08E−02	Caseonly	dom	CVD
  						03
  rs2626130	G	A	1.32	1.11	1.55	1.17E−	471/1436/	220/698/515	1.29	1.05	1.58	1.61E−02	cohort	37/89/58	30/122/95	1.37	1.04	1.82	2.74E−02	Caseonly	add	CVD
  						03	978
  rs4611134	A	G	1.55	1.19	2.01	1.20E−	388/723/377	322/721/419	1.54	1.11	2.14	1.05E−02	cohort	55/79/50	55/119/73	1.56	1.01	2.43	4.71E−02	Caseonly	rec	CVD
  						03
  rs17716275	A	G	2.03	1.32	3.13	1.32E−	7/286/2593	3/128/1303	1.91	1.11	3.29	2.01E−02	cohort	1/20/138	0/14/210	2.26	1.11	4.62	2.45E−02	CaseOnly	dom	CHD
  						03
  rs7094941	G	A	0.74	0.62	0.89	1.36E−	160/670/665	188/640/643	0.78	0.63	0.98	3.41E−02	cohort	14/64/81	27/116/81	0.66	0.48	0.91	1.06E−02	CaseOnly	add	CHD
  						03
  rs1076733	A	G	0.67	0.53	0.86	1.37E−	258/765/471	294/740/433	0.70	0.52	0.95	2.12E−02	cohort	34/81/69	40/139/68	0.62	0.41	0.94	2.34E−02	Caseonly	dom	CVD
  						03
  rs2290193	C	A	0.47	0.30	0.75	1.38E−	253/1183/	142/574/755	0.53	0.31	0.92	2.33E−02	cohort	7/80/97	26/100/	0.35	0.15	0.83	1.66E−02	Caseonly	rec	CVD
  						03	1529								121
  rs10103297	A	G	2.03	1.31	3.13	1.46E−	9/146/1339	7/114/1348	1.84	1.12	3.04	1.64E−02	cohort	1/14/144	2/6/216	2.74	1.13	6.65	2.60E−02	CaseOnly	dom	CHD
  						03
  rs12657484	G	A	1.49	1.16	1.90	1.49E−	133/632/727	107/581/782	1.36	1.01	1.85	4.48E−02	cohort	18/85/56	19/95/110	1.76	1.16	2.68	8.14E−03	CaseOnly	dom	CHD
  						03
  rs7910196	G	A	1.47	1.16	1.87	1.59E−	42/391/1062	26/338/1106	1.36	1.01	1.82	4.11E−02	cohort	4/54/101	2/54/168	1.72	1.14	2.59	1.01E−02	CaseOnly	add	CHD
  						03
  rs7767024	A	G	1.42	1.14	1.77	1.78E−	37/388/1070	45/361/1065	1.32	1.01	1.72	4.01E−02	cohort	2/61/121	4/50/193	1.69	1.13	2.51	1.05E−02	CaseOnly	add	CHD
  						03
  rs1474396	A	C	1.46	1.15	1.86	1.87E−	277/717/501	272/684/515	1.35	1.00	1.81	4.91E−02	cohort	32/100/52	31/118/98	1.37	1.14	2.62	9.39E−03	Caseonly	dom	CVD
  						03
  rs1182878	A	G	0.78	0.66	0.91	1.97E−	314/718/462	319/711/440	0.79	0.65	0.96	1.81E−02	cohort	41/80/63	57/137/53	0.75	0.57	0.99	4.36E−02	Caseonly	add	CVD
  						03
  rs2483641	A	G	0.59	0.43	0.83	2.06E−	14/230/1250	16/279/1174	0.65	0.43	0.97	3.34E−02	cohort	2/17/140	3/44/177	0.50	0.28	0.89	1.93E−02	CaseOnly	dom	CHD
  						03
  rs453625	A	G	0.62	0.46	0.85	2.44E−	18/236/1240	19/288/1164	0.66	0.46	0.95	2.70E−02	cohort	1/17/141	2/43/179	0.54	0.31	0.95	3.10E−02	CaseOnly	add	CHD
  						03
  rs7497613	A	G	0.55	0.37	0.81	2.66E−	649/1470/	331/720/382	0.65	0.46	0.91	1.17E−02	cohort	29/102/53	74/125/48	0.43	0.26	0.70	6.18E−04	Caseonly	rec	CVD
  						03	765
  rs2129571	A	G	0.53	0.34	0.80	2.81E−	17/215/1263	14/269/1186	0.62	0.43	0.90	1.22E−02	cohort	0/19/140	3/52/169	0.40	0.23	0.70	1.30E−03	CaseOnly	add	CHD
  						03
  rs16861467	G	A	0.49	0.31	0.78	2.93E−	15/205/1275	12/258/1201	0.60	0.41	0.87	7.69E−03	cohort	0/18/141	3/53/168	0.37	0.21	0.65	5.20E−04	CaseOnly	add	CHD
  						03
  rs10088524	G	A	1.57	1.17	2.11	3.00E−	14/255/1226	10/212/1249	1.46	1.00	2.11	4.73E−02	cohort	1/41/142	3/32/212	1.80	1.09	2.96	2.13E−02	Caseonly	dom	CVD
  						03
  rs10875941	G	A	0.63	0.45	0.89	9.49E−	118/582/795	141/581/748	0.73	0.54	0.99	4.41E−02	cohort	2/55/101	20/97/107	0.51	0.34	0.78	1.71E−03	CaseOnly	dom	CHD
  						03
  rs7616936	C	A	1.77	1.15	2.72	9.52E−	26/335/1133	24/279/1166	1.47	1.01	2.14	4.46E−02	cohort	0/42/117	2/28/194	2.30	1.36	3.88	1.83E−03	CaseOnly	dom	CHD
  						03
  rs6911817	A	G	2.85	1.25	6.50	1.28E−	2/80/1413	2/58/1411	2.15	1.08	4.25	2.83E−02	cohort	0/12/172	0/3/244	5.32	1.47	19.19	1.08E−02	Caseonly	add	CVD
  						02
  rs9658127	A	G	2.79	1.15	6.77	2.36E−	2/83/1409	2/60/1409	2.03	1.05	3.93	3.58E−02	cohort	0/12/172	0/3/244	5.32	1.47	19.19	1.08E−02	Caseonly	add	CVD
  						02

• TABLE 5
  			Meta-analysis

  allele

  P

  A1

  allele

  value

  CARE

  WOSCOPS

  (non-

  A2

  OR

  OR

  (ran-

  Prava

  Placebo

  OR

  OR

  Prava

  Placebo

  OR

  OR

  Mod-

  End-

  Marker

  ref)

  (ref)

  OR

  L95

  U95

  dom)

  Count

  Count

  OR

  L95

  U95

  P value

  Source

  Count

  Count

  OR

  L95

  U95

  P value

  Source

  el

  point

  rs11124322

  A

  G

  0.64

  0.50

  0.82

  3.92E−

  292/733/469

  322/733/416

  0.70

  0.51

  0.95

  2.18E−02

  cohort

  dom

  CVD

  04

  rs10193722

  C

  A

  71/167/119

  100/238/106

  0.62

  0.46

  0.85

  3.11E−03

  Caseonly

  32/81/71

  50/133/

  0.55

  0.36

  0.83

  4.27E−03

  Case-

  dom

  CVD

  64

  only

  rs1051344

  C

  G

  0.64

  0.51

  0.80

  1.07E−04

  262/694/537

  253/734/484

  0.64

  0.48

  0.86

  2.62E−03

  cohort

  431/1243/

  416/1234/

  0.64

  0.45

  0.92

  1.47E−02

  cohort

  dom

  CVD

  981

  1008

  rs1051334

  C

  A

  52/149/156

  73/230/140

  0.58

  0.44

  0.78

  3.23E−04

  Caseonly

  19/85/80

  41/132/

  0.58

  0.39

  0.86

  7.16E−03

  Case-

  dom

  CVD

  rs2030057

  T

  C

  0.60

  0.47

  0.75

  1.18E−05

  47/425/964

  61/410/959

  0.56

  0.42

  0.75

  7.88E−05

  cohort

  74

  only

  add

  CHD

  rs10740308

  A

  C

  7/79/214

  28/125/229

  0.61

  0.47

  0.81

  5.28E−04

  Caseonly

  3/41/115

  6/79/

  0.66

  0.44

  0.99

  4.49E−02

  Case-

  add

  CHD

  rs10831416

  G

  A

  1.73

  1.24

  2.42

  1.26E−03

  253/707/534

  233/665/573

  1.61

  1.08

  2.42

  2.09E−02

  cohort

  139

  only

  rec

  CHD

  rs10831415

  G

  A

  62/144/94

  50/179/153

  1.77

  1.17

  2.67

  7.05E−03

  Caseonly

  30/89/40

  23/118/

  2.02

  1.12

  3.63

  1.97E−02

  Case-

  rec

  CHD

  rs4657668

  G

  A

  1.34

  1.14

  1.58

  4.33E−04

  255/675/522

  213/689/532

  1.32

  1.08

  1.61

  7.53E−03

  cohort

  83

  only

  add

  CVD

  rs1229430

  G

  A

  77/170/110

  59/212/173

  1.39

  1.13

  1.70

  1.57E−03

  Caseonly

  33/87/64

  31/105/

  1.38

  1.05

  1.82

  2.11E−02

  Case-

  add

  CVD

  rs6497117

  C

  T

  0.52

  0.38

  0.70

  2.59E−05

  308/744/395

  328/721/382

  0.58

  0.40

  0.85

  5.29E−03

  cohort

  111

  only

  rec

  CHD

  rs12914132

  A

  G

  52/159/89

  97/179/106

  0.60

  0.41

  0.87

  7.98E−03

  Caseonly

  26/89/44

  68/114/

  0.42

  0.25

  0.70

  9.73E−04

  Case-

  rec

  CHD

  rs1529806

  G

  A

  1.42

  1.17

  1.73

  3.89E−04

  130/570/752

  94/561/779

  1.43

  1.12

  1.82

  4.17E−03

  cohort

  40

  only

  add

  CHD

  rs 1594887

  G

  A

  30/126/143

  19/134/229

  1.56

  1.22

  2.00

  3.71E−04

  Caseonly

  17/72/70

  13/95/

  1.42

  1.02

  1.97

  3.63E−02

  Case-

  add

  CHD

  rs3732788

  C

  T

  0.48

  0.32

  0.71

  2.39E−04

  16/212/1267

  14/275/1180

  0.56

  0.38

  0.81

  2.46E−03

  cohort

  116

  only

  add

  CHD

  rs16861476

  C

  A

  1/35/263

  5/83/294

  0.47

  0.31

  0.71

  2.92E−04

  Caseonly

  0/18/141

  3/53/168

  0.37

  0.21

  0.65

  5.20E−04

  Case-

  add

  CHD

  rs1773549

  C

  T

  1.45

  1.18

  1.78

  3.68E−04

  95/544/812

  81/527/826

  1.49

  1.17

  1.91

  1.44E−03

  cohort

  only

  add

  CHD

  rs 1737478

  A

  G

  29/125/146

  20/130/232

  1.54

  1.20

  1.96

  6.39E−04

  Caseonly

  6/62/91

  8/66/150

  1.36

  0.94

  1.95

  9.86E−02

  Case-

  add

  CHD

  rs1560901

  A

  G

  1.41

  1.16

  1.71

  5.74E−04

  125/573/753

  94/551/789

  1.41

  1.10

  1.80

  5.75E−03

  cohort

  only

  add

  CHD

  rs2196180

  A

  G

  28/126/146

  19/132/231

  1.53

  1.20

  1.96

  7.53E−04

  Caseonly

  17/71/71

  13/94/

  1.41

  1.02

  1.95

  3.97E−02

  Case-

  add

  CHD

  rs231355

  G

  C

  1.38

  1.16

  1.64

  2.11E−04

  357/708/387

  325/704/403

  1.30

  1.05

  1.61

  1.65E−02

  cohort

  117

  only

  add

  CHD

  rs231358

  G

  A

  82/159/59

  78/196/108

  1.39

  1.11

  1.74

  4.61E−03

  Caseonly

  58/70/31

  53/103/

  1.54

  1.16

  2.04

  2.94E−03

  Case-

  add

  CHD

  rs10875941

  C

  T

  0.64

  0.47

  0.88

  5.81E−03

  118/582/795

  141/581/748

  0.73

  0.54

  0.99

  4.41E−02

  cohort

  68

  only

  dom

  CHD

  rs2335451

  A

  C

  21/111/168

  44/157/181

  0.70

  0.51

  0.95

  2.33E−02

  Caseonly

  3/55/101

  20/96/

  0.53

  0.35

  0.80

  2.80E−03

  Case-

  dom

  CHD

  rs9834251

  G

  T

  1.75

  1.29

  2.38

  3.12E−04

  291/722/482

  247/700/524

  1.64

  1.11

  2.41

  1.22E−02

  cohort

  108

  only

  rec

  CVD

  rs2358931

  G

  A

  66/175/114

  47/235/159

  1.94

  1.29

  2.92

  1.45E−03

  Caseonly

  44/73/63

  35/109/

  1.96

  1.19

  3.21

  8.02E−03

  Case-

  rec

  CVD

  rs4765531

  A

  C

  0.67

  0.54

  0.81

  6.11E−05

  91/566/795

  113/564/757

  0.70

  0.55

  0.90

  5.60E−03

  cohort

  100

  only

  add

  CHD

  rs2593270

  A

  G

  13/111/176

  33/162/187

  0.69

  0.53

  0.88

  3.56E−03

  Caseonly

  7/52/100

  28/84/

  0.61

  0.44

  0.84

  2.90E−03

  Case-

  add

  CHD

  rs4765531

  A

  C

  0.66

  0.54

  0.81

  4.85E−05

  91/566/795

  113/564/757

  0.70

  0.55

  0.90

  5.60E−03

  cohort

  112

  only

  add

  CHD

  rs2656824

  A

  G

  12/111/177

  31/157/194

  0.71

  0.55

  0.92

  8.72E−03

  Caseonly

  7/51/101

  28/84/

  0.60

  0.43

  0.83

  2.14E−03

  Case-

  add

  CHD

  rs302290

  C

  T

  1.56

  1.24

  1.97

  1.65E−04

  102/571/775

  113/529/790

  1.46

  1.10

  1.94

  9.55E−03

  cohort

  112

  only

  dom

  CVD

  rs302296

  G

  A

  28/144/183

  31/140/273

  1.54

  1.15

  2.05

  3.34E−03

  Caseonly

  7/76/101

  12/68/

  1.79

  1.20

  2.66

  4.39E−03

  Case-

  dom

  CVD

  rs3806005

  A

  C

  2.25

  1.58

  3.21

  8.04E−06

  10/239/1203

  9/207/1218

  2.03

  1.32

  3.11

  1.26E−03

  cohort

  167

  only

  dom

  CHD

  rs3793048

  A

  C

  3/68/228

  6/47/328

  2.21

  1.44

  3.41

  3.17E−04

  Caseonly

  1/29/129

  2/15/207

  2.83

  1.50

  5.36

  1.36E−03

  Case-

  dom

  CHD

  rs1560901

  A

  G

  1.40

  1.16

  1.71

  6.32E−04

  125/573/753

  94/551/789

  1.41

  1.10

  1.80

  5.75E−03

  cohort

  only

  add

  CHD

  rs3861810

  G

  A

  28/127/145

  19/132/231

  1.54

  1.20

  1.97

  5.90E−04

  Caseonly

  17/72/70

  14/94/

  1.40

  1.01

  1.93

  4.41E−02

  Case-

  add

  CHD

  rs7179134

  A

  G

  3.72

  2.01

  6.89

  2.88E−05

  102/858/

  109/872/

  3.50

  1.40

  8.72

  7.28E−03

  cohort

  116

  only

  rec

  CVD

  1693

  1674

  rs4128766

  A

  G

  65/454/933

  68/457/909

  3.92

  1.70

  9.02

  1.31E−03

  cohort

  15/62/

  7/86/154

  3.18

  1.27

  8.01

  1.40E−02

  Case-

  rec

  CVD

  rs2148575

  A

  G

  0.35

  0.20

  0.59

  1.24E−04

  7/96/1392

  12/97/1362

  0.36

  0.19

  0.67

  1.17E−03

  cohort

  107

  only

  dom

  CVD

  rs4242084

  A

  C

  0/12/345

  4/38/402

  0.26

  0.12

  0.55

  4.34E−04

  Caseonly

  0/4/180

  0/16/231

  0.31

  0.10

  0.94

  3.92E−02

  Case-

  dom

  CVD

  rs5756670

  G

  A

  1.75

  1.33

  2.29

  5.75E−05

  320/688/443

  294/689/451

  1.82

  1.29

  2.56

  6.67E−04

  cohort

  only

  dom

  CHD

  rs4328731

  A

  C

  66/165/69

  72/177/133

  1.77

  1.26

  2.51

  1.15E−03

  Caseonly

  27/88/44

  43/97/84

  1.64

  1.05

  2.56

  2.96E−02

  Case-

  dom

  CHD

  rs7094941

  G

  A

  0.74

  0.61

  0.89

  1.16E−03

  160/670/665

  188/640/643

  0.78

  0.63

  0.98

  3.41E−02

  cohort

  only

  add

  CHD

  rs4980176

  C

  A

  26/131/143

  54/177/151

  0.75

  0.59

  0.95

  1.67E−02

  Caseonly

  13/64/81

  26/117/81

  0.64

  0.47

  0.89

  8.15E−03

  Case-

  add

  CHD

  rs1851830

  A

  G

  1.73

  1.24

  2.42

  1.29E−03

  218/673/560

  175/648/611

  1.70

  1.12

  2.60

  1.36E−02

  cohort

  only

  rec

  CVD

  rs6550706

  A

  G

  60/168/129

  42/210/192

  1.91

  1.25

  2.93

  2.76E−03

  Caseonly

  34/79/71

  28/94/124

  1.78

  1.03

  3.06

  3.84E−02

  Case-

  rec

  CVD

  rs10275879

  T

  A

  0.50

  0.36

  0.71

  8.02E−05

  349/746/400

  363/746/362

  0.44

  0.30

  0.65

  3.29E−05

  cohort

  only

  rec

  CHD

  rs6950121

  A

  C

  44/168/88

  105/188/89

  0.44

  0.29

  0.66

  6.20E−05

  Caseonly

  27/83/49

  55/99/70

  0.63

  0.38

  1.05

  7.68E−02

  Case-

  rec

  CHD

  rs7765440

  T

  C

  2.00

  1.49

  2.68

  4.37E−06

  11/210/1229

  16/215/1203

  1.82

  1.26

  2.62

  1.28E−03

  cohort

  only

  add

  CHD

  rs7751843

  A

  G

  5/59/236

  3/52/327

  1.69

  1.16

  2.46

  6.03E−03

  Caseonly

  2/41/115

  1/28/194

  2.38

  1.44

  3.93

  7.17E−04

  Case-

  add

  CHD

  rs2030057

  T

  C

  0.60

  0.47

  0.75

  1.18E−05

  47/425/964

  61/410/959

  0.56

  0.42

  0.75

  7.88E−05

  cohort

  only

  add

  CHD

  rs7901888

  A

  C

  6/80/214

  27/124/231

  0.62

  0.47

  0.82

  6.91E−04

  Caseonly

  3/41/115

  6/79/139

  0.66

  0.44

  0.99

  4.49E−02

  Case-

  add

  CHD

  rs3998860

  A

  G

  0.61

  0.49

  0.77

  2.29E−05

  129/851/1903

  75/416/941

  0.58

  0.44

  0.76

  7.97E−05

  cohort

  only

  add

  CHD

  rs7913568

  G

  A

  6/79/215

  31/121/228

  0.57

  0.43

  0.76

  9.24E−05

  Caseonly

  3/44/112

  6/80/138

  0.70

  0.47

  1.05

  8.17E−02

  Case-

  add

  CHD

  rs6931627

  G

  A

  0.74

  0.63

  0.87

  3.01 E−04

  237/758/500

  279/720/472

  0.75

  0.61

  0.92

  5.65E−03

  cohort

  only

  add

  CVD

  rs9467561

  A

  C

  54/164/139

  95/221/128

  0.71

  0.58

  0.87

  9.73E−04

  Caseonly

  23/94/67

  55/119/73

  0.72

  0.54

  0.95

  1.92E−02

  Case-

  add

  CVD

  rs912366

  G

  A

  1.61

  1.23

  2.11

  6.04E−04

  31/393/1071

  21/357/1093

  1.60

  1.14

  2.24

  6.82E−03

  cohort

  only

  dom

  CHD

  rs9554735

  A

  G

  5/95/200

  7/78/297

  1.77

  1.26

  2.49

  1.09E−03

  Caseonly

  6/46/107

  6/45/173

  1.64

  1.04

  2.58

  3.48E−02

  Case-

  dom

  CHD

  only

• TABLE 6
  	al-		Meta-analysis

  lele

  al-

  P

  A1

  dele

  value

  CARE

  WOSCOPS

  	(non-	A2		OR	OR	(ran-	Prava	Placebo		OR	OR	P		Prava	Placebo
  Marker	ref)	(ref)	OR	L95	U95	dom)	Count	Count	OR	L95	U95	value	Source	Count	Count
  rs1312-	A	G	1.65	1.30	2.08	3.28E−	7/89/204	8/76/298	1.69	1.19	2.39	3.07E−	case-	4/48/107	2/44/178
  9010						05						03	only
  rs4242-	A	C	1.93	1.41	2.64	3.42E−	51/156/	33/215/	2.12	1.33	3.38	1.64E−	case-	21/76/87	20/109/
  281						05	149	196				03	only		118
  rs6474-	A	G	1.54	1.25	1.90	5.17E−	17/120/	27/108/	1.55	1.14	2.12	5.78E−	case-	14/62/83	8/66/150
  228						05	163	247				03	only
  rs4240-	A	G	0.61	0.48	0.77	5.59E−	66/181/	115/215/	0.63	0.45	0.89	8.21E−	case-	32/99/53	65/118/
  808						05	110	114				03	only		64
  rs1312-	A	G	0.65	0.52	0.80	6.32E−	6/89/262	13/146/	0.64	0.47	0.87	4.55E−	case-	5/53/126	9/82/156
  6170						05		285				03	only
  rs7916-	G	A	2.09	1.45	2.99	6.46E−	43/136/	25/184/	2.33	1.39	3.92	1.37E−	case-	18/75/90	15/98/
  629						05	176	235				03	only		130
  rs1172-	A	C	0.64	0.51	0.80	6.95E−	11/85/	21/140/	0.65	0.48	0.89	7.62E−	case-	2/34/148	7/65/175
  1179						05	261	283				03	only
  rs2993-	A	G	0.66	0.54	0.81	7.06E−	9/96/252	29/157/	0.57	0.42	0.77	2.36E−	case-	8/58/118	14/92/
  156						05		257				04	only		141
  rs1077-	A	G	0.65	0.53	0.81	8.25E−	48/125/	56/196/	0.72	0.53	0.99	4.35E−	case-	25/64/70	37/119/
  4580						05	127	130				02	only		68
  rs1688-	G	A	1.56	1.25	1.94	8.49E−	17/95/	15/85/282	1.71	1.23	2.38	1.34E−	case-	7/49/103	6/52/166
  5715						05	188					03	only
  rs4870-	A	G	1.86	1.36	2.53	8.51E−	51/156/	35/213/	2.01	1.27	3.19	2.98E−	case-	21/75/87	20/109/
  109						05	148	194				03	only		118
  rs1768-	A	C	0.69	0.58	0.83	9.66E−	7/96/254	18/155/	0.65	0.50	0.85	1.46E−	case-	5/50/129	10/86/
  8430						05		271				03	only		151
  rs7332-	A	G	2.06	1.43	2.96	9.98E−	35/147/	26/195/	1.83	1.07	3.13	2.75E−	case-	22/69/93	15/103/
  076						05	174	223				02	only		129
  rs694-	G	A	0.55	0.41	0.75	1.26E−	38/157/	72/175/	0.61	0.40	0.95	2.89E−	case-	20/76/63	43/103/
  780						04	105	135				02	only		78
  rs483-	A	G	0.68	0.56	0.83	1.30E−	27/138/	51/193/	0.72	0.54	0.95	1.94E−	case-	17/78/89	25/128/
  6745						04	192	200				02	only		94
  rs701-	A	G	1.50	1.22	1.86	1.44E−	18/122/	19/130/	1.34	0.98	1.82	6.27E−	case-	13/75/71	13/75/
  8577						04	160	233				02	only		136
  rs1158-	A	G	0.62	0.48	0.79	1.46E−	5/64/	11/107/	0.67	0.47	0.94	2.23E−	case-	5/22/157	1/50/196
  5647						04	288	326				02	only
  rs442-	A	G	0.66	0.54	0.82	1.51E−	17/87/	20/140/	0.73	0.53	1.00	5.30E−	case-	11/49/99	16/91/
  0312						04	196	222				02	only		117
  rs744-	G	A	1.52	1.21	1.91	2.61E−	13/79/	13/79/290	1.42	1.01	1.99	4.61E−	case-	7/53/99	3/57/164
  9527						04	208					02	only
  rs783-	A	G	1.52	1.21	1.91	2.75E−	47/177/	62/196/	1.45	1.04	2.04	3.10E−	case-	29/86/44	46/91/87
  9562						04	76	124				02	only
  rs265-	A	G	0.29	0.15	0.57	3.05E−	6/120/	20/114/	0.38	0.15	0.97	4.34E−	case-	2/46/111	14/71/
  5222						04	174	248				02	only		139
  rs261-	G	A	1.57	1.23	2.00	3.23E−	10/73/	9/75/298	1.43	1.00	2.05	4.98E−	case-	3/35/121	1/40/
  6548						04	217					02	only		183
  rs1049-	G	A	0.71	0.59	0.86	3.37E−	10/90/	20/134/	0.75	0.57	0.99	3.91E−	case-	4/46/109	8/88/128
  7883						04	200	228				02	only
  rs699-	A	G	3.99	1.83	8.72	5.20E−	13/89/	6/126/250	2.76	1.02	7.46	4.55E−	case-	7/44/108	1/64/159
  8016						04	198					02	only
  rs1114-	A	G	1.88	1.32	2.70	5.49E−	37/133/	27/182/	1.74	1.03	2.95	3.92E−	case-	17/76/91	10/124/
  8285						04	187	235				02	only		113
  rs730-	G	A	2.22	1.62	3.04	5.97E−	201/674/	171/681/	2.50	1.57	4.00	1.26E−	cohort	27/74/58	23/115/
  5949						07	620	619				04			86
  rs26-	A	G	0.62	0.51	0.76	2.80E−	183/654/	200/642/	0.54	0.40	0.73	7.41E−	cohort	273/	279/
  4122						06	658	629				05		1142/	1125/
  														1235	1251
  rs100-	A	G	1.37	1.19	1.57	6.63E−	214/663/	176/665/	1.35	1.10	1.65	3.95E−	cohort	400/	384/
  9748						06	617	629				03		1202/	1214/
  														1054	1064
  rs133-	A	G	1.60	1.30	1.96	6.96E−	306/1284/	152/631/	1.87	1.38	2.54	5.89E−	cohort	19/67/73	19/87/
  6400						06	1371	686				05			118
  rs210-	A	G	0.63	0.51	0.77	7.94E−	181/652/	201/643/	0.55	0.40	0.74	1.10E−	cohort	17/56/83	24/106/
  8425						06	661	624				04			92
  rs232-	G	A	1.37	1.19	1.57	1.10E−	215/665/	183/664/	1.34	1.10	1.64	4.19E−	cohort	30/86/68	31/96/
  7412						05	615	623				03			120
  rs1700-	A	G	1.56	1.28	1.91	1.16E−	89/477/	61/487/	1.63	1.22	2.17	1.00E−	cohort	8/70/105	6/71/
  2013						05	929	923				03			170
  rs101-	G	A	1.72	1.35	2.20	1.49E−	18/281/	22/266/	1.63	1.14	2.33	7.11E−	cohort	1/36/147	3/29/215
  5199						05	1196	1183				03
  rs707-	C	A	1.54	1.27	1.87	1.49E−	282/1256/	136/621/	1.68	1.26	2.23	3.59E−	cohort	19/81/84	23/90/
  8016						05	1343	675				04			134
  rs658-	A	G	1.53	1.26	1.86	1.66E−	281/1256/	136/618/	1.68	1.26	2.23	3.56E−	cohort	19/81/84	23/90/
  5412						05	1347	678				04			134
  rs19-	G	A	1.67	1.32	2.11	1.91E−	340/768/	326/759/	1.58	1.09	2.30	1.68E−	cohort	613/	588/
  8476						05	384	385				02		1353/	1343/
  														665	710
  rs2648-	A	G	1.98	1.44	2.72	2.42E−	172/636/	156/625/	2.00	1.25	3.19	3.71E−	cohort	28/75/81	18/125/
  694						05	683	686				03			104
  rs1094-	A	G	1.58	1.28	1.96	2.89E−	19/277/	23/270/	1.72	1.25	2.36	8.43E−	cohort	2/42/140	3/45/198
  5874						05	1197	1178				04
  rs1190-	A	C	0.67	0.56	0.81	3.38E−	176/666/	170/666/	0.61	0.46	0.81	5.65E−	cohort	285/	285/
  706						05	653	635				04		1100/	1176/
  														1252	1190
  rs3763-	G	C	0.75	0.66	0.86	3.75E−	259/676/	243/723/	0.76	0.62	0.92	6.03E−	cohort	417/	411/
  978						05	559	503				03		1255/	1224/
  														984	1024
  rs1113-	G	A	0.64	0.51	0.79	3.78E−	57/646/	29/302/	0.67	0.48	0.92	1.34E−	cohort	34/563/	46/555/
  8314						05	2183	1103				02		2059	2057
  rs1310-	C	A	0.65	0.53	0.80	4.01E−	104/895/	52/452/	0.67	0.49	0.90	8.24E−	cohort	8/52/124	12/85/
  7334						05	1967	967				03			150
  rs668-	A	G	1.60	1.28	2.01	4.01E−	18/382/	17/347/	1.83	1.32	2.54	2.93E−	cohort	7/45/132	5/49/193
  5920						05	1092	1104				04
  rs261-	A	C	1.42	1.20	1.68	4.06E−	97/494/	95/475/	1.39	1.09	1.78	8.81E−	cohort	9/52/98	6/68/150
  6552						05	904	901				03
  rs211-	A	C	0.66	0.54	0.81	5.17E−	260/679/	227/753/	0.76	0.57	1.01	6.27E−	cohort	28/74/82	31/139/
  0564						05	556	490				02			77
  rs100-	G	A	0.66	0.54	0.81	5.34E−	66/494/	58/525/	0.76	0.57	1.01	5.90E−	cohort	10/52/	12/97/
  12485						05	931	885				02		122	138
  rs179-	G	A	1.75	1.33	2.29	5.98E−	241/690/	183/758/	1.69	1.10	2.61	1.71E−	cohort	473/	491/
  8093						05	564	530				02		1222/	1279/
  														957	890
  rs478-	A	G	0.60	0.46	0.77	6.30E−	323/714/	325/743/	0.64	0.44	0.92	1.72E−	cohort	29/89/41	69/99/
  7415						05	414	364				02			56
  rs1173-	G	A	0.61	0.48	0.78	7.05E−	645/1484/	324/732/	0.54	0.38	0.78	8.84E−	cohort	37/100/	59/111/
  4256						05	756	378				04		47	77
  rs126-	A	G	0.67	0.55	0.81	7.06E−	257/656/	256/677/	0.63	0.47	0.84	1.89E−	cohort	20/73/91	32/113/
  6489						05	582	538				03			102
  rs238-	A	C	1.46	1.21	1.76	7.50E−	62/704/	27/322/	1.65	1.23	2.22	8.40E−	cohort	55/719/	68/672/
  250						05	2117	1083				04		1881	1921
  rs258-	A	G	0.72	0.61	0.85	7.53E−	57/508/	79/507/	0.69	0.54	0.87	1.62E−	cohort	7/63/114	17/102/
  8350						05	928	883				03			128
  rs498-	G	A	1.47	1.21	1.77	9.18E−	43/443/	46/403/	1.59	1.20	2.11	1.33E−	cohort	4/55/100	7/63/154
  657						05	1007	1020				03
  rs642-	C	A	0.68	0.56	0.83	9.43E−	477/1399/	237/700/	0.70	0.53	0.93	1.46E−	cohort	391/	439/
  7807						05	1084	529				02		1269/	1236/
  														993	983
  rs61-	G	A	0.56	0.41	0.75	1.01E−	238/719/	247/673/	0.62	0.41	0.94	2.29E−	cohort	20/76/63	43/102/
  9825						04	536	551				02			78
  rs94-	G	A	1.85	1.36	2.52	1.02E−	193/661/	158/705/	1.86	1.18	2.95	7.99E−	cohort	21/76/86	19/108/
  78241						04	640	605				03			118
  rs172-	A	G	1.47	1.21	1.79	1.02E−	216/667/	169/670/	1.57	1.18	2.08	1.90E−	cohort	21/86/76	22/98/
  7746						04	612	632				03			127
  rs250-	A	G	0.76	0.66	0.87	1.04E−	370/670/	300/766/	0.69	0.56	0.86	7.20E−	cohort	486/	527/
  5039						04	455	405				04		1334/	1350/
  														834	786
  rs447-	G	A	0.66	0.54	0.82	1.05E−	154/685/	177/679/	0.74	0.54	1.00	4.86E−	cohort	20/66/73	23/115/
  2926						04	656	615				02			86
  rs653-	A	G	0.65	0.52	0.81	1.07E−	326/757/	356/736/	0.62	0.46	0.86	3.59E−	cohort	40/88/56	52/140/
  9231						04	412	379				03			55
  rs795-	A	G	0.76	0.66	0.87	1.09E−	328/718/	319/766/	0.77	0.64	0.94	1.14E−	cohort	30/82/72	44/137/
  9965						04	448	386				02			66
  rs974-	A	G	0.67	0.55	0.82	1.13E−	259/677/	228/750/	0.77	0.57	1.03	7.47E−	cohort	28/74/82	31/139/
  950						04	558	492				02			77
  rs152-	A	G	0.72	0.60	0.85	1.14E−	81/566/	122/580/	0.63	0.49	0.82	4.61E−	cohort	9/60/90	23/86/
  4962						04	848	767				04			115
  rs1782-	A	C	0.30	0.16	0.55	1.15E−	148/947/	78/476/	0.24	0.09	0.64	4.37E−	cohort	3/60/96	13/70/
  1383						04	1791	880				03			141
  rs1051-	A	G	0.67	0.55	0.82	1.19E−	59/493/	57/525/	0.76	0.57	1.02	6.53E−	cohort	11/52/121	13/96/
  8335						04	942	889				02			138
  rs122-	A	C	1.66	1.28	2.15	1.21E−	690/1425/	339/726/	1.65	1.16	2.36	5.58E−	cohort	38/76/45	43/100/
  65891						04	771	369				03			79
  rs480-	A	G	2.00	1.40	2.85	1.22E−	4/144/	7/126/	2.20	1.33	3.64	2.01E−	cohort	3/19/162	1/14/232
  7536						04	1346	1338				03
  rs991-	A	G	0.64	0.51	0.80	1.22E−	34/363/	29/380/	0.72	0.51	1.01	5.56E−	cohort	5/36/117	6/72/146
  4580						04	1098	1062				02
  rs646-	A	G	0.56	0.41	0.75	1.24E−	236/723/	239/683/	0.62	0.41	0.95	2.76E−	cohort	20/75/63	43/101/78
  749						04	536	548				02
  rs100-	A	C	1.51	1.22	1.86	1.25E−	72/516/	67/505/	1.57	1.15	2.13	4.17E−	cohort	9/58/92	8/64/152
  3322						04	907	899				03
  rs466-	A	G	1.56	1.24	1.96	1.26E−	18/382/	17/347/	1.86	1.31	2.65	5.46E−	cohort	53/567/	57/576/
  0234						04	1095	1105				04		2036	2031
  rs403-	G	A	0.65	0.52	0.81	1.27E−	304/693/	271/747/	0.65	0.47	0.90	8.85E−	cohort	27/65/67	55/105/
  8018						04	498	453				03			64
  rs771-	G	A	0.68	0.56	0.83	1.32E−	137/588/	134/612/	0.69	0.52	0.91	8.96E−	cohort	7/67/110	18/106/
  0039						04	769	725				03			123
  rs131-	A	G	1.48	1.21	1.81	1.33E−	111/911/	43/443/	1.38	1.04	1.85	2.74E−	cohort	12/70/	9/67/171
  50189						04	1941	983				02		102
  rs126-	A	G	0.68	0.55	0.83	1.34E−	65/504/	60/526/	0.75	0.57	1.01	5.51E−	cohort	10/52/	13/96/
  46525						04	926	885				02		122	138
  rs211-	A	G	0.41	0.26	0.65	1.36E−	180/1056/	97/534/	0.43	0.23	0.83	1.18E−	cohort	6/73/105	15/84/
  3334						04	1730	840				02			148
  rs25-	A	G	2.19	1.46	3.27	1.37E−	0/84/1359	3/83/	2.09	1.15	3.80	1.59E−	cohort	0/13/170	0/6/241
  1817						04		1341				02
  rs2574	C	G	1.53	1.23	1.91	1.39E−	377/740/	338/715/	1.48	1.07	2.04	1.77E−	cohort	57/87/39	56/128/
  						04	378	418				02			63
  rs1267-	A	G	0.68	0.56	0.83	1.40E−	146/640/	167/647/	0.65	0.49	0.87	2.98E−	cohort	14/76/94	30/117/
  9254						04	709	657				03			100
  rs1234-	A	G	2.10	1.43	3.09	1.47E−	138/583/	98/607/	2.35	1.30	4.27	4.90E−	cohort	180/	154/
  1095						04	774	766				03		1006/	1001/
  														1468	1503
  rs170-	C	A	1.31	1.14	1.51	1.47E−	239/709/	219/690/	1.26	1.03	1.54	2.34E−	cohort	44/90/50	34/125/
  48681						04	546	562				02			88
  rs194-	A	G	0.56	0.42	0.76	1.48E−	228/724/	237/679/	0.62	0.40	0.95	2.82E−	cohort	20/75/64	43/102/
  2876						04	543	554				02			79
  rs265-	A	G	1.40	1.18	1.66	1.52E−	82/530/	59/504/	1.43	1.11	1.85	5.19E−	cohort	11/62/86	10/62/
  7940						04	882	908				03			152
  rs494-	G	A	0.57	0.42	0.76	1.54E−	237/727/	241/690/	0.63	0.42	0.96	3.08E−	cohort	19/77/62	43/104/
  111						04	531	540				02			77
  rs206-	G	A	0.64	0.51	0.81	1.59E−	320/753/	364/713/	0.58	0.41	0.81	1.54E−	cohort	45/94/45	79/109/
  0022						04	422	393				03			59
  rs733-	A	G	2.16	1.45	3.22	1.59E−	3/121/	0/101/	2.01	1.13	3.57	1.75E−	cohort	1/10/148	1/7/216
  8174						04	1371	1370				02
  rs120-	G	A	0.76	0.66	0.88	1.61E−	220/701/	246/692/	0.74	0.60	0.90	2.93E−	cohort	24/90/70	41/120/
  48902						04	574	532				03			86
  rs674-	A	G	1.49	1.21	1.83	1.63E−	99/581/	92/528/	1.52	1.12	2.06	7.63E−	cohort	6/66/87	9/62/153
  6182						04	814	851				03
  rs727-	A	C	0.46	0.31	0.69	1.68E−	3/109/	5/133/	0.37	0.19	0.69	1.84E−	cohort	0/10/174	1/18/228
  6749						04	1378	1328				03
  rs19-	G	A	1.56	1.24	1.97	1.68E−	339/773/	327/761/	1.59	1.09	2.30	1.48E−	cohort	620/	591/
  8460						04	382	382				02		1368/	1353/
  														663	713
  rs778-	A	G	1.53	1.23	1.92	1.75E−	362/729/	343/725/	1.41	1.02	1.96	3.74E−	cohort	59/85/40	56/130/
  5499						04	404	403				02			61
  rs99-	C	A	0.57	0.42	0.76	1.76E−	227/724/	237/677/	0.63	0.41	0.96	3.27E−	cohort	20/75/64	43/102/
  6022						04	543	555				02			79
  rs722-	A	G	0.64	0.51	0.81	1.79E−	34/352/	25/379/	0.73	0.52	1.04	7.77E−	cohort	6/36/117	6/72/146
  2186						04	1109	1067				02
  rs19-	G	A	1.57	1.24	1.99	1.80E−	349/771/	336/765/	1.44	1.00	2.07	4.86E−	cohort	50/69/40	42/122/60
  8464						04	374	369				02
  rs169-	C	A	0.68	0.55	0.83	1.80E−	197/673/	205/670/	0.75	0.55	1.02	7.03E−	cohort	13/64/82	33/105/86
  34059						04	625	595				02
  rs156-	G	A	0.56	0.42	0.76	1.84E−	14/347/	8/175/	0.59	0.39	0.88	1.10E−	cohort	0/14/145	0/42/182
  6221						04	2605	1288				02
  rs812-	A	G	0.46	0.31	0.69	1.85E−	3/108/	5/133/	0.37	0.19	0.69	1.89E−	cohort	0/10/174	1/18/228
  9810						04	1384	1333				03
  rs134-	G	A	1.45	1.19	1.77	1.89E−	60/459/	74/439/	1.45	1.09	1.93	1.14E−	cohort	106/820/	101/844/
  4081						04	976	958				02		1729	1709
  rs79-	A	G	1.54	1.23	1.94	1.96E−	26/352/	21/324/	1.47	1.07	2.03	1.91E−	cohort	8/43/133	3/41/203
  18692						04	1117	1126				02
  rs46-	A	G	1.55	1.23	1.95	2.04E−	341/721/	302/709/	1.42	1.02	1.99	3.98E−	cohort	55/87/42	54/122/71
  86740						04	433	460				02
  rs128-	A	G	0.77	0.67	0.88	2.05E−	262/693/	249/739/	0.76	0.62	0.93	7.13E−	cohort	20/89/75	41/133/73
  17873						04	538	481				03
  rs7508	G	A	1.48	1.20	1.82	2.08E−	125/612/	120/550/	1.42	1.05	1.93	2.27E−	cohort	15/77/67	20/92/112
  						04	758	801				02
  rs27-	A	G	0.57	0.43	0.77	2.13E−	189/670/	216/652/	0.51	0.33	0.78	2.30E−	cohort	19/94/71	40/115/92
  1046						04	636	603				03
  rs201-	A	G	0.64	0.51	0.81	2.15E−	21/274/	18/268/	0.67	0.47	0.95	2.57E−	cohort	2/23/133	8/47/169
  1318						04	1155	1147				02
  rs113-	A	G	1.48	1.20	1.83	2.29E−	59/663/	29/317/	1.64	1.23	2.18	8.11E−	cohort	2/35/147	2/43/202
  6046						04	2244	1125				04
  rs145-	G	A	0.69	0.57	0.84	2.29E−	43/415/	43/464/	0.63	0.47	0.84	1.89E−	cohort	4/43/112	8/81/135
  0092						04	1037	962				03
  rs707-	G	A	1.45	1.19	1.78	2.37E−	37/350/	32/325/	1.42	1.07	1.88	1.43E−	cohort	8/39/135	3/38/206
  0244						04	1107	1114				02
  rs892-	G	A	0.60	0.46	0.79	2.39E−	273/736/	279/695/	0.64	0.43	0.96	2.95E−	cohort	20/80/59	51/100/73
  162						04	485	496				02
  rs656-	A	G	0.65	0.52	0.82	2.41E−	42/350/	35/383/	0.76	0.56	1.04	8.26E−	cohort	2/24/133	4/54/166
  3805						04	1102	1052				02
  rs99-	G	A	0.65	0.52	0.82	2.42E−	35/355/	30/376/	0.71	0.50	1.01	5.44E−	cohort	6/37/116	6/72/146
  06737						04	1104	1064				02
  rs47-	G	A	1.63	1.25	2.12	2.49E−	20/235/	8/198/	1.79	1.24	2.59	1.75E−	cohort	0/29/155	0/29/217
  5420						04	1237	1263				03
  rs176-	G	A	0.51	0.36	0.73	2.61E−	156/606/	168/601/	0.58	0.36	0.94	2.65E−	cohort	13/78/93	31/116/
  44708						04	732	702				02			100
  rs705-	A	G	1.53	1.22	1.91	2.61E−	33/353/	30/321/	1.43	1.03	1.97	3.11E−	cohort	8/43/132	3/38/206
  7780						04	1109	1119				02
  rs4773	A	G	0.69	0.56	0.84	2.68E−	249/694/	250/712/	0.65	0.48	0.87	3.94E−	cohort	20/73/91	32/111/
  						04	552	509				03			104
  rs674-	G	A	1.53	1.22	1.92	2.69E−	395/755/	335/732/	1.33	0.96	1.85	8.45E−	cohort	49/91/44	47/123/77
  2894						04	343	404				02
  rs104-	G	A	0.74	0.62	0.87	2.70E−	225/1125/	118/555/	0.67	0.52	0.86	1.39E−	cohort	157/975/	170/995/
  5916						04	1533	760				03		1521	1496
  rs643-	A	G	0.67	0.53	0.83	2.76E−	298/688/	264/756/	0.70	0.51	0.97	3.05E−	cohort	34/70/55	42/134/48
  5378						04	509	451				02
  rs134-	A	G	1.44	0.18	1.75	2.78E−	121/612/	118/565/	1.33	1.01	1.76	4.53E−	cohort	22/84/78	18/87/142
  11119						04	762	788				02
  rs153-	A	C	0.68	0.56	0.84	2.79E−	330/1271/	180/641/	0.65	0.48	0.88	5.54E−	cohort	13/54/92	21/89/114
  1842						04	1365	650				03
  rs9857	G	A	0.74	0.63	0.87	2.85E−	96/554/	120/608/	0.68	0.54	0.86	1.14E−	cohort	6/64/114	18/82/147
  						04	844	741				03
  rs9960	A	G	1.47	1.19	1.80	2.88E−	54/483/	41/442/	1.55	1.15	2.08	3.88E−	cohort	10/57/117	7/63/177
  						04	958	987				03
  rs131-	G	A	0.67	0.54	0.83	2.88E−	81/850/	39/434/	0.70	0.52	0.95	2.39E−	cohort	5/53/126	8/83/156
  03899						04	1955	961				02
  rs684-	G	A	0.66	0.53	0.83	2.88E−	316/740/	329/731/	0.75	0.55	1.02	6.96E−	cohort	38/90/56	65/133/49
  8512						04	394	373				02
  rs101-	A	C	1.36	1.15	1.61	2.95E−	64/473/	54/454/	1.31	1.02	1.67	3.21E−	cohort	11/74/99	8/76/163
  81805						04	957	963				02
  rs11-	C	A	1.42	1.17	1.71	3.02E−	47/455/	50/410/	1.34	1.01	1.77	4.41E−	cohort	7/52/100	5/54/165
  29570						04	950	974				02
  rs99-	A	C	1.77	1.30	2.41	3.07E−	349/1376/	156/710/	1.79	1.13	2.84	1.30E−	cohort	21/75/87	20/108/
  86576						04	1241	605				02			117
  rs13-	A	G	0.44	0.28	0.69	3.07E−	133/614/	145/609/	0.59	0.34	1.03	6.31E−	cohort	6/62/91	28/84/
  52236						04	746	716				02			112
  rs77-	A	G	0.65	0.52	0.82	3.13E−	20/302/	20/324/	0.69	0.50	0.97	3.13E−	cohort	0/23/136	6/43/174
  70578						04	1128	1087				02
  rs27-	G	A	1.58	1.23	2.03	3.14E−	326/750/	314/702/	1.57	1.07	2.30	2.05E−	cohort	517/	452/
  48901						04	419	454				02		1250/	1342/
  														885	868
  rs115-	G	A	0.77	0.67	0.89	3.21E−	286/710/	298/652/	0.81	0.66	1.01	5.63E−	cohort	21/85/52	61/104/59
  5875						04	499	521				02
  rs67-	C	A	0.67	0.54	0.83	3.25E−	15/305/	25/315/	0.70	0.51	0.95	2.23E−	cohort	2/31/151	4/54/189
  5163						04	1175	1131				02
  rs106-	G	A	0.66	0.53	0.83	3.29E−	335/738/	342/724/	0.67	0.48	0.95	2.34E−	cohort	615/	672/
  8705						04	421	405				02		1268/	1320/
  														767	661
  rs150-	G	A	1.50	1.20	1.88	3.45E−	26/322/	21/320/	1.36	0.99	1.87	6.03E−	cohort	2/44/113	1/48/175
  5469						04	1147	1130				02
  rs62-	A	G	0.70	0.57	0.85	3.56E−	107/559/	115/547/	0.77	0.58	1.03	7.39E−	cohort	16/63/	25/111/
  3400						04	786	772				02		105	111
  rs60-	G	A	1.47	1.19	1.82	3.60E−	128/565/	110/562/	1.72	1.30	2.28	1.37E−	cohort	18/72/94	23/87/137
  40760						04	801	799				04
  rs173-	A	G	0.68	0.55	0.84	3.68E−	47/422/	63/453/	0.65	0.48	0.89	6.66E−	cohort	2/54/128	4/81/162
  10169						04	1025	955				03
  rs762-	A	C	4.25	1.92	9.43	3.74E−	44/369/	37/324/	4.02	1.31	12.33	1.50E−	cohort	6/46/132	2/58/187
  3808						04	1081	1109				02
  rs77-	A	G	0.48	0.32	0.72	3.78E−	3/110/	5/129/	0.38	0.21	0.71	2.41E−	cohort	0/10/174	1/18/228
  638540						04	1382	1337				03
  rs58-	A	G	0.59	0.44	0.79	3.85E−	239/715/	240/683/	0.62	0.41	0.94	2.53E−	cohort	19/76/64	43/103/78
  1401						04	539	548				02
  rs42-	A	G	0.69	0.56	0.84	3.90E−	34/355/	29/377/	0.78	0.59	1.04	8.76E−	cohort	1/35/148	3/76/168
  51580						04	1106	1065				02
  rs6-	G	A	0.59	0.44	0.79	3.91E−	238/721/	242/677/	0.62	0.40	0.94	2.40E−	cohort	19/77/63	43/103/78
  03940						04	534	552				02
  rs13-	G	A	1.50	1.20	1.88	4.01E−	43/468/	42/389/	1.29	0.93	1.79	1.23E−	cohort	5/42/112	3/41/180
  117043						04	984	1039				01
  rs380-	A	G	0.48	0.32	0.72	4.10E−	3/114/	2/136/	0.39	0.20	0.76	5.25E−	cohort	0/9/150	1/23/200
  0202						04	1375	1329				03
  rs107-	A	G	0.76	0.65	0.88	4.18E−	202/706/	231/708/	0.82	0.65	1.02	7.21E−	cohort	19/77/63	36/118/70
  38948						04	587	530				02
  rs62-	A	G	0.59	0.45	0.79	4.21E−	238/724/	243/682/	0.62	0.41	0.94	2.32E−	cohort	19/76/64	43/104/77
  3584						04	532	546				02
  rs955-	A	G	1.49	1.20	1.87	4.24E−	27/383/	24/334/	1.70	1.21	2.39	2.28E−	cohort	44/636/	46/585/
  7509						04	1084	1112				03		1977	2031
  rs116 -	G	A	1.35	1.14	1.60	4.29E−	168/985/	79/486/	1.31	1.02	1.69	3.36E−	cohort	122/885/	111/846/
  68038						04	1731	868				02		1648	1702
  rs108-	A	C	1.29	1.12	1.49	4.62E−	697/1481/	328/745/	1.40	1.12	1.74	3.12E−	cohort	625/	604/
  02865						04	705	360				03		1329/	1353/
  														702	706
  rs1703-	A	G	1.44	1.17	1.77	5.05E−	49/471/	57/435/	1.52	1.11	2.09	8.90E−	cohort	114/855/	112/836/
  5071						04	975	979				03		1681	1709
  rs14-	A	G	1.39	1.16	1.68	5.20E−	118/612/	113/587/	1.29	1.02	1.64	3.56E−	cohort	20/72/67	15/75/134
  39269						04	765	770				02
  rs20-	A	G	1.41	1.16	1.72	5.61E−	93/537/	96/473/	1.30	0.98	1.72	7.23E−	cohort	12/79/93	9/89/149
  8025						04	861	897				02
  rs126-	G	A	0.67	0.53	0.84	5.65E−	21/337/	26/366/	0.70	0.50	0.98	3.67E−	cohort	7/36/141	8/70/169
  08167						04	1137	1078				02
  rs13-	G	A	0.70	0.57	0.85	5.74E−	173/606/	182/638/	0.81	0.60	1.09	1.64E−	cohort	20/54/85	25/105/94
  3871						04	716	651				01
  rs706-	A	C	1.65	1.24	2.19	5.82E−	11/240/	9/204/	1.69	1.10	2.59	1.62E−	cohort	3/32/124	1/26/197
  8975						04	1244	1258				02
  rs186-	A	G	0.74	0.62	0.88	5.84E−	70/500/	93/548/	0.69	0.53	0.88	3.18E−	cohort	4/57/123	12/80/155
  6386						04	925	829				03
  rs158-	A	G	1.57	1.21	2.03	6.11E−	552/1477/	251/764/	1.52	1.04	2.22	3.16E−	cohort	45/72/41	41/116/66
  0713						04	937	456				02
  rs936-	G	A	0.70	0.57	0.86	6.61E−	93/549/	109/559/	0.73	0.54	0.99	4.56E−	cohort	11/58/90	25/92/107
  671						04	852	801				02
  rs373-	A	G	1.51	1.19	1.91	6.62E−	118/604/	117/568/	1.32	0.98	1.79	6.98E−	cohort	20/71/68	16/74/134
  2136						04	772	786				02
  rs177-	A	G	0.72	0.59	0.87	6.84E−	50/407/	46/464/	0.67	0.51	0.89	6.28E−	cohort	5/45/109	8/82/134
  18867						04	1038	961				03
  rs57-	G	A	1.53	1.20	1.95	7.02E−	23/261/	18/240/	1.40	0.99	1.98	5.39E−	cohort	6/38/140	2/33/212
  64592						04	1211	1212				02
  rs28-	G	A	1.41	1.16	1.72	7.07E−	118/563/	92/541/	1.31	0.98	1.74	6.81E−	cohort	14/84/86	14/92/141
  80563						04	770	801				02
  rs156-	G	A	0.78	0.68	0.90	7.07E−	279/650/	205/735/	0.73	0.58	0.90	3.95E−	cohort	402/	447/
  4078						04	563	530				03		1248/	1288/
  														992	915
  rs108-	A	G	1.66	1.24	2.23	7.22E−	0/203/	0/157/	1.83	1.19	2.81	5.83E−	cohort	0/32/152	2/31/214
  17479						04	1280	1305				03
  rs47-	A	G	1.26	1.10	1.45	7.28E−	341/724/	324/705/	1.20	0.99	1.46	6.17E−	cohort	47/101/	57/112/
  8859						04	430	442				02		36	78
  rs101-	G	A	1.64	1.23	2.19	7.44E−	190/675/	167/704/	1.40	0.92	2.14	1.15E−	cohort	27/77/80	25/124/98
  06852						04	630	599				01
  rs1265-	A	G	1.43	1.16	1.75	7.50E−	105/584/	85/532/	1.48	1.09	2.00	1.21E−	cohort	17/72/70	12/89/123
  9030						04	806	854				02
  rs15-	A	G	1.49	1.18	1.89	7.74E−	369/716/	271/747/	1.57	1.11	2.23	1.06E−	cohort	47/79/58	48/127/72
  36506						04	408	453				02
  rs218-	G	A	0.70	0.57	0.86	7.76E−	467/1361/	218/711/	0.66	0.48	0.90	7.98E−	cohort	18/61/80	32/97/95
  4393						04	1166	540				03
  rs110-	G	A	1.47	1.17	1.84	7.81E−	42/404/	33/375/	1.26	0.90	1.75	1.75E−	cohort	4/52/103	2/48/174
  77308						04	1005	1026				01
  rs79-	C	G	0.71	0.58	0.87	8.35E−	225/681/	260/682/	0.69	0.51	0.92	1.04E−	cohort	28/71/84	41/104/
  15250						04	589	529				02			101
  rs46-	G	A	1.27	1.10	1.46	8.63E−	319/719/	266/733/	1.23	1.01	1.50	3.84E−	cohort	37/104/	36/126/
  89078						04	454	469				02		43	85
  rs286-	A	G	0.75	0.64	0.89	9.44E−	68/511/	79/508/	0.81	0.64	1.03	8.13E−	cohort	4/64/116	15/97/135
  9680						04	872	847				02
  rs122-	A	G	2.18	1.37	3.45	9.89E−	0/150/	0/62/1368	2.20	1.07	4.55	3.26E−	cohort	0/13/171	1/7/239
  86877						04	2726					02
  rs104-	A	G	0.24	0.08	0.70	9.13E−	0/58/1394	1/68/1365	0.43	0.20	0.92	2.98E−	cohort	0/1/183	0/13/234
  60737						03						02

  WOSCOPS

  PROVEIT

  			OR	OR	P		Atorv	Prav		OR	OR			Mod-	End-
  	Marker	OR	L95	U95	value	Source	Count	Count	OR	L95	U95	P value	Source	el	point
  	rs1312-	1.90	1.19	3.03	6.81E−	case-	6/47/	5/51/196	1.39	0.89	2.16	1.44E−	case-	dom	CHD
  	9010				03	only	138					01	only
  	rs4242-	1.46	0.76	2.79	2.51E−	case-	37/78/	27/127/	2.08	1.20	3.60	8.70E−	case-	rec	CVD
  	281				01	only	76	98				03	only
  	rs6474-	1.83	1.21	2.79	4.63E−	case-	9/87/95	19/90/	1.32	0.90	1.93	1.52E−	case-	dom	CHD
  	228				03	only		143				01	only
  	rs4240-	0.61	0.38	0.98	4.06E−	case-	28/97/66	59/123/	0.56	0.34	0.92	2.26E−	case-	rec	CVD
  	808				02	only		70				02	only
  	rs1312-	0.78	0.52	1.17	2.36E−	case-	6/37/148	7/81/164	0.53	0.34	0.82	4.23E−	case-	dom	CVD
  	6170				01	only						03	only
  	rs7916-	1.66	0.81	3.41	1.64E−	case-	21/82/86	15/101/	2.11	1.05	4.26	3.73E−	case-	rec	CVD
  	629				01	only		136				02	only
  	rs1172-	0.60	0.38	0.95	2.87E−	case-	14/41/	12/80/	0.64	0.41	0.99	4.53E−	case-	dom	CVD
  	1179				02	only	136	160				02	only
  	rs2993-	0.76	0.51	1.13	1.73E−	case-	11/57/	23/84/	0.75	0.50	1.10	1.42E−	case-	dom	CVD
  	156				01	only	123	145				01	only
  	rs1077-	0.56	0.37	0.86	7.45E−	case-	26/85/80	40/132/	0.63	0.43	0.94	2.27E−	case-	dom	CHD
  	4580				03	only		80				02	only
  	rs1688-	1.58	1.01	2.46	4.38E−	case-	10/60/	9/67/176	1.34	0.89	2.00	1.59E−	case-	dom	CHD
  	5715				02	only	121					01	only
  	rs4870-	1.47	0.77	2.80	2.45E−	case-	37/78/76	28/124/	1.97	1.14	3.40	1.48E−	case-	rec	CVD
  	109				01	only		98				02	only
  	rs1768-	0.71	0.50	1.01	5.62E−	case-	4/51/136	10/77/	0.77	0.54	1.11	1.57E−	case-	add	CVD
  	8430				02	only		165				01	only
  	rs7332-	2.18	1.09	4.34	2.70E−	case-	23/69/99	14/100/	2.40	1.18	4.88	1.62E−	case-	rec	CVD
  	076				02	only		138				02	only
  	rs694-	0.62	0.35	1.10	1.02E−	case-	19/106/	50/108/	0.40	0.21	0.73	3.11E−	case-	rec	CHD
  	780				01	only	66	94				03	only
  	rs483-	0.65	0.44	0.97	3.26E−	case-	13/76/	25/119/	0.65	0.44	0.96	2.82E−	case-	dom	CVD
  	6745				02	only	102	108				02	only
  	rs701-	1.94	1.28	2.94	1.68E−	case-	15/79/97	18/83/	1.44	0.98	2.12	6.13E−	case-	dom	CHD
  	8577				03	only		151				02	only
  	rs1158-	0.67	0.40	1.12	1.25E−	case-	10/26/	14/61/	0.49	0.30	0.80	4.76E−	case-	dom	CVD
  	5647				01	only	155	177				03	only
  	rs442-	0.64	0.42	0.97	3.58E−	case-	8/56/127	10/106/	0.59	0.40	0.87	8.31E−	case-	dom	CHD
  	0312				02	only		136				03	only
  	rs744-	1.71	1.10	2.65	1.72E−	case-	8/61/122	8/60/184	1.53	1.01	2.30	4.28E−	case-	dom	CHD
  	9527				02	only						02	only
  	rs783-	1.63	1.05	2.53	3.07E−	case-	47/95/49	39/125/	1.54	1.01	2.34	4.35E−	case-	dom	CHD
  	9562				02	only		88				02	only
  	rs265-	0.20	0.05	0.91	3.78E−	case-	3/80/108	17/71/	0.23	0.07	0.80	2.09E−	case-	rec	CHD
  	5222				02	only		164				02	only
  	rs261-	1.37	0.83	2.26	2.18E−	case-	8/57/126	2/52/198	2.02	1.28	3.16	2.29E−	case-	dom	CHD
  	6548				01	only						03	only
  	rs1049-	0.67	0.46	0.98	4.15E−	case-	3/57/131	13/88/	0.68	0.48	0.96	2.91E−	case-	add	CHD
  	7883				02	only		151				02	only
  	rs699-	9.63	1.17	79.34	3.53E−	case-	9/61/121	2/73/177	6.19	1.27	30.09	2.39E−	case-	rec	CHD
  	8016				02	only						02	only
  	rs1114-	2.30	1.02	5.16	4.42E−	case-	27/72/92	22/101/	1.87	1.01	3.48	4.67E−	case-	rec	CVD
  	8285				02	only		129				02	only
  	rs730-	1.74	0.95	3.17	7.16E−	case-	130/459/	133/443/	2.34	1.29	4.22	4.97E−	cohort	rec	CHD
  	5949				02	only	419	434				03
  	rs26-	0.66	0.46	0.95	2.58E−	cohort	144/421/	136/459/	0.72	0.50	1.05	8.92E−	cohort	dom	CHD
  	4122				02		454	419				02
  	rs100-	1.35	1.05	1.72	1.81E−	cohort	121/455/	118/435/	1.43	1.09	1.88	1.06E−	cohort	add	CVD
  	9748				02		444	460				02
  	rs133-	1.35	0.90	2.04	1.53E−	case-	151/404/	116/431/	1.46	1.00	2.12	4.82E−	cohort	dom	CHD
  	6400				01	only	459	465				02
  	rs210-	0.62	0.41	0.94	2.45E−	case-	148/415/	138/469/	0.77	0.53	1.12	1.69E−	cohort	dom	CHD
  	8425				02	only	447	405				01
  	rs232-	1.41	1.07	1.86	1.56E−	case-	122/453/	119/431/	1.38	1.05	1.81	2.08E−	cohort	add	CVD
  	7412				02	only	443	463				02
  	rs1700-	1.66	1.11	2.48	1.28E−	case-	54/346/	57/351/	1.38	0.94	2.02	9.55E−	cohort	dom	CVD
  	2013				02	only	616	604				02
  	rs101-	1.66	0.98	2.78	5.77E−	case-	19/226/	11/200/	1.93	1.23	3.03	4.06E−	cohort	dom	CVD
  	5199				02	only	775	803				03
  	rs707-	1.44	0.98	2.12	6.19E−	case-	140/415/	112/439/	1.41	0.97	2.04	7.29E−	cohort	dom	CVD
  	8016				02	only	466	466				02
  	rs658-	1.44	0.98	2.12	6.19E−	case-	144/404/	116/433/	1.39	0.96	2.02	8.12E−	cohort	dom	CVD
  	5412				02	only	469	465				02
  	rs19-	1.61	1.06	2.46	2.63E−	cohort	65/85/41	55/132/	1.85	1.21	2.84	4.85E−	case-	rec	CHD
  	8476				02			65				03	only
  	rs2648-	2.29	1.22	4.29	9.83E−	case-	108/459/	113/452/	1.72	0.95	3.11	7.49E−	cohort	rec	CVD
  	694				03	only	453	451				02
  	rs1094-	1.24	0.81	1.91	3.19E−	case-	22/196/	20/201/	1.72	1.15	2.58	8.16E−	cohort	add	CVD
  	5874				01	only	799	795				03
  	rs1190-	0.70	0.50	0.99	4.37E−	cohort	103/476/	129/443/	0.76	0.52	1.10	1.42E−	cohort	dom	CVD
  	706				02		441	445				01
  	rs376-	0.68	0.53	0.87	2.46E−	cohort	154/448/	171/478/	0.84	0.65	1.10	2.06E−	cohort	add	CVD
  	3978				03		418	365				01
  	rs111-	0.59	0.39	0.89	1.22E−	cohort	22/228/	19/256/	0.64	0.43	0.95	2.83E−	cohort	add	CHD
  	38314				02		765	740				02
  	rs131-	0.74	0.50	1.11	1.49E−	case-	46/286/	37/293/	0.53	0.35	0.80	2.36E−	cohort	dom	CVD
  	07334				01	only	687	683				03
  	rs668-	1.40	0.90	2.18	1.35E−	case-	28/243/	19/227/	1.45	0.93	2.25	9.96E−	cohort	dom	CVD
  	5920				01	only	750	771				02
  	rs26-	1.32	0.92	1.89	1.37E−	case-	86/353/	73/362/	1.55	1.15	2.08	3.98E−	cohort	add	CHD
  	16552				01	only	581	581				03
  	rs21-	0.56	0.37	0.83	3.82E−	case-	182/476/	204/470/	0.60	0.40	0.89	1.17E−	cohort	dom	CVD
  	10564				03	only	360	341				02
  	rs100-	0.64	0.43	0.95	2.56E−	case-	61/341/	47/357/	0.54	0.36	0.79	1.78E−	cohort	dom	CVD
  	12485				02	only	619	613				03
  	rs1798-	1.63	1.03	2.59	3.71E−	cohort	187/469/	160/456/	2.00	1.17	3.42	1.13E−	cohort	rec	CHD
  	093				02		364	396				02
  	rs478-	0.52	0.31	0.85	8.69E−	case-	33/101/	64/118/	0.62	0.38	0.99	4.76E−	case-	rec	CHD
  	7415				03	only	57	70				02	only
  	rs117-	0.81	0.51	1.30	3.88E−	case-	219/511/	226/491/	0.57	0.36	0.89	1.46E−	cohort	rec	CVD
  	34256				01	only	278	287				02
  	rs126-	0.74	0.50	1.09	1.26E−	case-	169/473/	180/468/	0.67	0.45	0.98	4.00E−	cohort	dom	CVD
  	6489				01	only	368	364				02
  	rs23-	1.43	1.03	1.97	3.13E−	cohort	22/239/	22/241/	1.24	0.86	1.80	2.50E−	cohort	add	CVD
  	8250				02		759	752				01
  	rs25-	0.68	0.49	0.95	2.31E−	case-	52/340/	41/363/	0.82	0.59	1.13	2.30E−	cohort	add	CVD
  	88350				02	only	616	606				01
  	rs498-	1.18	0.81	1.72	4.00E−	case-	8/66/117	4/69/179	1.57	1.10	2.24	1.40E−	case-	add	CHD
  	657				01	only						02	only
  	rs642-	0.67	0.47	0.96	2.85E−	cohort	157/456/	179/464/	0.66	0.45	0.97	3.26E−	cohort	dom	CVD
  	7807				02		393	369				02
  	rs61-	0.61	0.34	1.09	9.80E−	case-	19/107/	50/109/	0.40	0.21	0.73	3.11E−	case-	rec	CHD
  	9825				02	only	65	93				03	only
  	rs94-	1.54	0.80	2.96	1.97E−	case-	37/78/76	27/127/	2.08	1.20	3.60	8.70E−	case-	rec	CVD
  	78241				01	only		98				03	only
  	rs172-	1.50	1.02	2.20	4.18E−	case-	154/450/	120/441/	1.30	0.89	1.90	1.68E−	cohort	dom	CVD
  	7746				02	only	409	449				01
  	rs250-	0.78	0.60	1.02	6.83E−	cohort	252/494/	254/499/	0.84	0.65	1.09	1.97E−	cohort	add	CHD
  	5039				02		269	258				01
  	rs447-	0.71	0.47	1.08	1.10E−	case-	22/63/	29/123/	0.53	0.36	0.78	1.17E−	case-	dom	CHD
  	2926				01	only	106	100				03	only
  	rs653-	0.66	0.43	1.02	5.92E−	case-	51/80/60	60/131/	0.68	0.45	1.05	7.89E−	case-	dom	CVD
  	9231				02	only		61				02	only
  	rs795-	0.75	0.57	1.00	4.97E−	case-	34/92/65	67/115/	0.74	0.57	0.97	2.87E−	case-	add	CVD
  	9965				02	only		70				02	only
  	rs974-	0.56	0.37	0.83	3.82E−	case-	179/455/	201/455/	0.64	0.43	0.94	2.37E−	cohort	dom	CVD
  	950				03	only	376	352				02
  	rs152-	0.78	0.56	1.08	1.28E−	case-	11/64/	15/105/	0.80	0.58	1.10	1.70E−	case-	add	CHD
  	4962				01	only	116	132				01	only
  	rs1782-	0.33	0.09	1.18	8.85E−	case-	5/70/116	18/89/	0.35	0.13	0.96	4.18E−	case-	rec	CHD
  	1383				02	only		145				02	only
  	rs1051-	0.65	0.44	0.97	3.35E−	case-	9/47/135	9/99/143	0.55	0.37	0.82	3.26E−	case-	dom	CVD
  	8335				02	only						03	only
  	rs122-	1.27	0.77	2.09	3.43E−	case-	53/82/56	39/127/	2.13	1.33	3.41	1.78E−	case-	rec	CHD
  	65891				01	only		85				03	only
  	rs480-	2.13	1.07	4.24	3.22E−	case-	1/16/174	1/14/237	1.53	0.74	3.16	2.50E−	case-	dom	CVD
  	7536				02	only						01	only
  	rs991-	0.67	0.42	1.05	7.85E−	case-	3/41/147	10/82/	0.51	0.33	0.78	2.05E−	case-	dom	CHD
  	4580				02	only		160				03	only
  	rs646-	0.62	0.35	1.10	9.97E−	case-	19/106/	50/108/	0.40	0.21	0.73	3.11E−	case-	rec	CHD
  	749				02	only	66	94				03	only
  	rs100-	1.52	0.99	2.32	5.29E−	case-	11/70/	5/82/	1.41	0.95	2.08	8.60E−	case-	dom	CHD
  	3322				02	only	110	165				02	only
  	rs466-	1.32	0.88	1.97	1.80E−	cohort	28/238/	20/222/	1.45	0.93	2.25	9.97E−	cohort	dom	CHD
  	0234				01		750	774				02
  	rs403-	0.55	0.36	0.85	6.49E−	case-	44/88/59	68/119/	0.76	0.50	1.17	2.11E−	case-	dom	CHD
  	8018				03	only		65				01	only
  	rs771-	0.65	0.44	0.96	3.15E−	case-	11/63/	17/102/	0.70	0.48	1.03	7.21E−	case-	dom	CVD
  	0039				02	only	117	133				02	only
  	rs131-	1.83	1.23	2.72	3.06E−	case-	7/70/114	18/65/	1.36	0.92	2.02	1.22E−	case-	dom	CVD
  	50189				03	only		169				01	only
  	rs126-	0.64	0.43	0.95	2.56E−	case-	65/338/	46/360/	0.59	0.40	0.87	7.91E−	cohort	dom	CVD
  	46525				02	only	616	605				03
  	rs211-	0.53	0.20	1.41	2.06E−	case-	7/73/111	27/92/	0.29	0.12	0.70	6.07E−	case-	rec	CVD
  	3334				01	only		133				03	only
  	rs25-	2.98	1.11	8.03	3.08E−	case-	1/22/168	0/17/235	2.02	1.06	3.86	3.35E−	case-	add	CVD
  	1817				02	only						02	only
  	rs2574	1.54	1.00	2.38	5.03E−	case-	258/474/	237/537/	1.62	1.07	2.44	2.30E−	cohort	rec	CVD
  					02	only	287	242				02
  	rs1267-	0.65	0.44	0.95	2.77E−	case-	19/77/95	26/115/	0.79	0.53	1.16	2.21E−	case-	dom	CVD
  	9254				02	only		111				01	only
  	rs1234-	2.38	1.14	4.96	2.05E−	cohort	79/404/	64/384/	1.63	0.82	3.24	1.68E−	cohort	rec	CHD
  	1095				02		536	565				01
  	rs170-	1.49	1.13	1.98	5.10E−	case-	30/91/70	30/114/	1.25	0.95	1.66	1.15E−	case-	add	CVD
  	48681				03	only		108				01	only
  	rs194-	0.62	0.35	1.10	1.02E−	case-	18/108/	48/108/	0.41	0.23	0.76	4.18E−	case-	rec	CHD
  	2876				01	only	65	96				03	only
  	rs265-	1.57	1.12	2.21	9.90E−	case-	7/75/109	12/80/	1.20	0.86	1.67	2.77E−	case-	add	CHD
  	7940				03	only		160				01	only
  	rs494-	0.59	0.33	1.06	7.90E−	case-	19/107/	49/109/	0.44	0.25	0.79	5.96E−	case-	rec	CHD
  	111				02	only	65	94				03	only
  	rs206-	0.69	0.45	1.07	9.41E−	case-	42/81/68	72/101/	0.72	0.46	1.12	1.40E−	case-	rec	CVD
  	0022				02	only		79				01	only
  	rs733-	2.01	0.79	5.14	1.44E−	case-	1/24/166	1/14/237	2.50	1.25	4.99	9.45E−	case-	dom	CHD
  	8174				01	only						03	only
  	rs120-	0.87	0.66	1.16	3.46E−	case-	20/77/94	53/90/	0.72	0.55	0.94	1.73E−	case-	add	CVD
  	48902				01	only		109				02	only
  	rs674-	1.79	1.17	2.73	6.97E−	case-	73/376/	65/375/	1.25	0.86	1.81	2.38E−	cohort	dom	CHD
  	6182				03	only	568	576				01
  	rs727-	0.68	0.31	1.52	3.50E−	case-	4/84/931	4/108/	0.45	0.22	0.90	2.45E−	cohort	dom	CVD
  	6749				01	only		904				02
  	rs19-	1.54	1.01	2.34	4.59E−	cohort	273/496/	243/509/	1.55	1.02	2.36	3.93E−	cohort	rec	CHD
  	8460				02		244	253				02
  	rs778-	1.62	1.05	2.49	2.89E−	case-	258/486/	214/516/	1.68	1.09	2.61	1.97E−	cohort	rec	CVD
  	5499				02	only	267	281				02
  	rs99-	0.62	0.35	1.10	1.02E−	case-	18/108/	48/108/	0.41	0.23	0.76	4.18E−	case-	rec	CHD
  	6022				01	only	65	96				03	only
  	rs722-	0.68	0.44	1.07	9.51E−	case-	2/40/148	9/82/161	0.50	0.32	0.77	1.48E−	case-	dom	CHD
  	2186				02	only						03	only
  	rs198-	2.04	1.27	3.29	3.35E−	case-	291/482/	263/493/	1.44	0.96	2.17	7.90E−	cohort	rec	CHD
  	464				03	only	231	248				02
  	rs169-	0.57	0.38	0.87	8.36E−	case-	119/460/	121/463/	0.65	0.45	0.95	2.65E−	cohort	dom	CHD
  	34059				03	only	439	430				02
  	rs15-	0.41	0.21	0.78	6.53E−	case-	4/99/917	3/125/	0.68	0.37	1.26	2.22E−	cohort	add	CHD
  	66221				03	only		887				01
  	rs812-	0.68	0.31	1.52	3.50E−	case-	3/84/933	5/107/	0.45	0.22	0.91	2.69E−	cohort	dom	CVD
  	9810				01	only		902				02
  	rs134-	1.58	1.10	2.26	1.25E−	cohort	8/61/122	8/68/176	1.31	0.88	1.96	1.86E−	case-	dom	CVD
  	4081				02							01	only
  	rs791-	1.76	1.11	2.79	1.59E−	case-	0/52/139	3/48/201	1.48	0.95	2.32	8.37E−	case-	dom	CVD
  	8692				02	only						02	only
  	rs468-	1.53	0.98	2.37	5.90E−	case-	53/85/53	45/141/	1.86	1.17	2.97	8.84E−	case-	rec	CVD
  	6740				02	only		66				03	only
  	rs128-	0.69	0.52	0.93	1.38E−	case-	165/458/	179/482/	0.85	0.65	1.10	2.15E−	cohort	add	CVD
  	17873				02	only	398	355				01
  	rs7508	1.39	0.92	2.10	1.17E−	case-	10/91/90	15/87/	1.65	1.13	2.43	1.03E−	case-	dom	CHD
  					01	only		150				02	only
  	rs27-	0.58	0.32	1.05	6.99E−	case-	29/89/73	50/103/	0.68	0.40	1.18	1.74E−	case-	rec	CVD
  	1046				02	only		99				01	only
  	rs201-	0.60	0.38	0.95	2.83E−	case-	1/34/156	3/64/185	0.63	0.40	0.99	4.35E−	case-	add	CHD
  	1318				02	only						02	only
  	rs113-	1.16	0.74	1.83	5.13E−	case-	5/47/139	2/50/200	1.48	0.98	2.22	6.15E−	case-	add	CVD
  	6046				01	only						02	only
  	rs145-	0.68	0.46	1.01	5.29E−	case-	6/51/134	10/79/	0.81	0.57	1.15	2.41E−	case-	add	CHD
  	0092				02	only		163				01	only
  	rs707-	1.72	1.15	2.59	8.56E−	case-	3/56/132	5/56/191	1.30	0.87	1.94	2.06E−	case-	add	CVD
  	0244				03	only						01	only
  	rs89-	0.47	0.27	0.84	9.96E−	case-	29/99/63	54/127/	0.64	0.39	1.06	8.48E−	case-	rec	CHD
  	2162				03	only		71				02	only
  	rs656-	0.59	0.37	0.94	2.75E−	case-	3/29/159	8/66/178	0.53	0.35	0.80	2.73E−	case-	add	CHD
  	3805				02	only						03	only
  	rs990-	0.70	0.45	1.10	1.23E−	case-	2/43/146	9/83/160	0.53	0.35	0.81	3.19E−	case-	dom	CHD
  	6737				01	only						03	only
  	rs475-	1.37	0.78	2.38	2.73E−	case-	2/38/151	1/36/215	1.57	0.95	2.59	7.80E−	case-	dom	CVD
  	420				01	only						02	only
  	rs176-	0.52	0.26	1.03	5.89E−	case-	7/101/83	25/122/	0.34	0.14	0.81	1.45E−	case-	rec	CVD
  	44708				02	only		105				02	only
  	rs705-	1.93	1.21	3.07	5.99E−	case-	3/53/135	7/50/195	1.41	0.91	2.18	1.24E−	case-	dom	CVD
  	7780				03	only						01	only
  	rs4773	0.77	0.52	1.13	1.79E−	case-	28/86/77	52/120/	0.68	0.45	1.01	5.68E−	case-	dom	CVD
  					01	only		80				02	only
  	rs67-	1.56	0.98	2.46	5.86E−	case-	60/81/50	50/138/	1.94	1.24	3.03	3.53E−	case-	rec	CVD
  	42894				02	only		64				03	only
  	rs104-	0.80	0.58	1.10	1.78E−	cohort	15/61/	20/103/	0.79	0.58	1.07	1.29E−	case-	add	CHD
  	5916				01		115	129				01	only
  	rs643-	0.52	0.33	0.82	4.94E−	case-	33/84/74	46/125/	0.74	0.50	1.10	1.40E−	case-	dom	CHD
  	5378				03	only		81				01	only
  	rs134-	1.83	1.24	2.69	2.34E−	case-	23/82/86	24/98/	1.32	0.89	1.94	1.69E−	case-	dom	CVD
  	11119				03	only		130				01	only
  	rs153-	0.76	0.50	1.15	1.90E−	case-	17/74/	21/123/	0.67	0.46	0.98	4.15E−	case-	dom	CHD
  	1842				01	only	100	108				02	only
  	rs9857	0.83	0.60	1.15	2.67E−	case-	12/63/	15/108/	0.78	0.57	1.07	1.18E−	case-	add	CVD
  					01	only	116	129				01	only
  	rs9960	1.41	0.94	2.13	9.91E−	case-	11/57/	8/64/180	1.37	0.92	2.06	1.25E−	case-	dom	CVD
  					02	only	123					01	only
  	rs131-	0.78	0.52	1.17	2.32E−	case-	6/37/148	7/82/163	0.53	0.34	0.81	3.72E−	case-	dom	CVD
  	03899				01	only						03	only
  	rs684-	0.55	0.35	0.86	8.50E−	case-	48/84/59	65/131/	0.64	0.41	0.98	4.02E−	case-	dom	CVD
  	8512				03	only		56				02	only
  	rs1018-	1.58	1.13	2.21	7.18E−	case-	16/60/	10/79/	1.28	0.93	1.75	1.27E−	case-	add	CVD
  	1805				03	only	115	163				01	only
  	rs112-	1.58	1.08	2.31	1.83E−	case-	10/65/	6/73/173	1.41	1.00	1.98	4.80E−	case-	add	CHD
  	9570				02	only	116					02	only
  	rs998-	1.46	0.76	2.78	2.54E−	case-	36/79/76	27/126/	2.00	1.15	3.47	1.36E−	case-	rec	CVD
  	6576				01	only		98				02	only
  	rs135-	0.27	0.11	0.66	4.24E−	case-	10/84/97	30/93/	0.39	0.18	0.84	1.60E−	case-	rec	CHD
  	2236				03	only		129				02	only
  	rs777-	0.57	0.34	0.94	2.88E−	case-	3/35/153	6/66/180	0.65	0.43	0.99	4.58E−	case-	add	CHD
  	0578				02	only						02	only
  	rs274-	1.81	1.11	2.95	1.80E−	cohort	226/504/	196/502/	1.43	0.92	2.23	1.14E−	cohort	rec	CHD
  	8901				02		290	318				01
  	rs115-	0.66	0.49	0.89	6.12E−	case-	32/84/75	58/111/	0.79	0.61	1.03	7.69E−	case-	add	CHD
  	5875				03	only		83				02	only
  	rs67-	0.71	0.46	1.11	1.32E−	case-	1/33/157	5/64/183	0.58	0.38	0.90	1.44E−	case-	add	CVD
  	5163				01	only						02	only
  	rs106-	0.74	0.49	1.11	1.45E−	cohort	44/84/	55/141/	0.58	0.38	0.89	1.23E−	case-	dom	CHD
  	8705				01		63	56				02	only
  	rs150-	1.47	0.94	2.30	9.11E−	case-	5/44/142	2/36/213	1.85	1.20	2.85	5.58E−	case-	add	CHD
  	5469				02	only						03	only
  	rs62-	0.62	0.42	0.92	1.60E−	case-	20/55/	25/100/	0.65	0.44	0.96	3.00E−	case-	dom	CVD
  	3400				02	only	116	127				02	only
  	rs60-	1.23	0.83	1.81	2.98E−	case-	21/70/99	18/84/	1.34	0.91	1.97	1.35E−	case-	dom	CVD
  	40760				01	only		150				01	only
  	rs173-	0.81	0.54	1.23	3.22E−	case-	4/43/143	9/79/164	0.61	0.40	0.92	2.01E−	case-	dom	CVD
  	10169				01	only						02	only
  	rs762-	4.22	0.83	21.33	8.20E−	case-	7/37/147	2/55/195	4.79	0.98	23.38	5.28E−	case-	rec	CVD
  	3808				02	only						02	only
  	rs77-	0.68	0.31	1.52	3.50E−	case-	6/76/935	4/106/	0.49	0.24	1.00	5.04E−	cohort	dom	CVD
  	638540				01	only		906				02
  	rs58-	0.59	0.33	1.05	7.35E−	case-	137/494/	185/471/	0.54	0.31	0.95	3.34E−	cohort	rec	CHD
  	1401				02	only	385	359				02
  	rs42-	0.55	0.35	0.85	6.68E−	case-	4/28/159	4/63/185	0.64	0.42	0.98	4.06E−	case-	add	CVD
  	51580				03	only						02	only
  	rs6-	0.59	0.33	1.05	7.35E−	case-	136/503/	182/481/	0.55	0.31	0.96	3.64E−	cohort	rec	CHD
  	03940				02	only	380	354				02
  	rs13-	1.73	1.07	2.78	2.45E−	case-	6/61/124	5/55/192	1.74	1.15	2.64	9.53E−	case-	dom	CHD
  	117043				02	only						03	only
  	rs380-	0.49	0.22	1.07	7.33E−	case-	2/67/937	1/77/922	0.59	0.29	1.20	1.43E−	cohort	add	CHD
  	0202				02	only						01
  	rs107-	0.74	0.55	1.02	6.20E−	case-	14/99/78	43/120/	0.68	0.51	0.91	9.76E−	case-	add	CHD
  	38948				02	only		88				03	only
  	rs62-	0.59	0.33	1.05	7.35E−	case-	141/482/	186/460/	0.56	0.33	0.98	4.18E−	cohort	rec	CHD
  	3584				02	only	390	360				02
  	rs955-	1.42	0.95	2.11	8.72E−	cohort	8/47/136	5/55/192	1.29	0.83	2.00	2.62E−	case-	dom	CHD
  	7509				02							01	only
  	rs116 -	1.25	0.91	1.71	1.62E−	cohort	16/82/93	15/83/	1.54	1.11	2.12	8.96E−	case-	add	CHD
  	68038				01			154				03	only
  	rs108-	1.16	0.90	1.50	2.52E−	cohort	57/88/46	49/137/	1.29	0.98	1.69	6.73E−	case-	add	CHD
  	02865				01			66				02	only
  	rs1703-	1.22	0.84	1.77	3.03E−	cohort	10/73/	8/73/171	1.60	1.07	2.37	2.06E−	case-	dom	CHD
  	5071				01		108					02	only
  	rs14-	1.74	1.27	2.39	6.20E−	case-	21/83/87	22/97/	1.27	0.94	1.72	1.25E−	case-	add	CHD
  	39269				04	only		133				01	only
  	rs20-	1.52	1.03	2.23	3.55E−	case-	8/80/102	11/78/	1.55	1.05	2.29	2.60E−	case-	dom	CVD
  	8025				02	only		162				02	only
  	rs126-	0.66	0.42	1.02	5.92E−	case-	23/209/	21/253/	0.63	0.40	0.98	4.24E−	cohort	dom	CVD
  	08167				02	only	785	740				02
  	rs13-	0.64	0.42	0.96	3.04E−	case-	19/73/99	27/124/	0.59	0.40	0.87	8.11E−	case-	dom	CHD
  	3871				02	only		101				03	only
  	rs706-	2.02	1.16	3.51	1.24E−	case-	0/33/158	1/34/216	1.32	0.78	2.22	3.05E−	case-	dom	CHD
  	8975				02	only						01	only
  	rs186-	0.81	0.57	1.14	2.23E−	case-	6/61/124	12/93/	0.77	0.55	1.08	1.32E−	case-	add	CVD
  	6386				01	only		147				01	only
  	rs158-	1.68	1.03	2.75	3.75E−	case-	39/103/	37/138/	1.55	0.94	2.56	8.88E−	case-	rec	CHD
  	0713				02	only	49	77				02	only
  	rs936-	0.70	0.46	1.06	8.80E−	case-	14/60/	21/102/	0.64	0.44	0.95	2.62E−	case-	dom	CHD
  	671				02	only	117	129				02	only
  	rs373-	1.99	1.32	3.01	1.13E−	case-	22/84/85	25/94/	1.42	0.96	2.09	8.12E−	case-	dom	CHD
  	2136				03	only		133				02	only
  	rs177-	0.74	0.51	1.08	1.18E−	case-	5/51/135	10/79/	0.77	0.54	1.10	1.57E−	case-	add	CHD
  	18867				01	only		163				01	only
  	rs57-	1.87	1.14	3.07	1.29E−	case-	3/44/144	6/41/205	1.48	0.91	2.42	1.15E−	case-	dom	CVD
  	64592				02	only						01	only
  	rs28-	1.51	1.03	2.22	3.69E−	case-	15/85/90	23/86/	1.51	1.02	2.24	3.78E−	case-	dom	CVD
  	80563				02	only		143				02	only
  	rs156-	0.79	0.61	1.03	8.02E−	case-	29/98/64	53/115/	0.86	0.66	1.14	2.98E−	case-	add	CHD
  	4078				02	only		84				01	only
  	rs108-	1.37	0.81	2.33	2.42E−	case-	2/23/166	0/20/232	1.77	0.95	3.31	7.42E−	case-	dom	CVD
  	17479				01	only						02	only
  	rs47-	1.33	1.02	1.75	3.89E−	case-	49/92/50	59/99/94	1.32	1.01	1.73	4.14E−	case-	add	CVD
  	8859				02	only						02	only
  	rs101-	1.56	0.87	2.79	1.38E−	case-	40/78/73	28/118/	2.19	1.29	3.71	3.79E−	case-	rec	CVD
  	06852				01	only		106				03	only
  	rs1265-	1.53	1.01	2.30	4.31E−	case-	10/82/99	16/92/	1.27	0.86	1.86	2.24E−	case-	dom	CHD
  	9030				02	only		144				01	only
  	rs15-	1.43	0.90	2.26	1.29E−	case-	56/80/55	56/132/	1.44	0.93	2.23	1.05E−	case-	rec	CVD
  	36506				01	only		64				01	only
  	rs218-	0.72	0.48	1.08	1.13E−	case-	30/78/83	44/116/	0.75	0.51	1.11	1.51E−	case-	dom	CHD
  	4393				01	only		92				01	only
  	rs110-	1.86	1.18	2.93	7.39E−	case-	1/63/127	4/58/190	1.55	1.02	2.36	3.98E−	case-	dom	CHD
  	77308				03	only						02	only
  	rs79-	0.81	0.55	1.19	2.83E−	case-	33/78/80	41/128/	0.66	0.44	0.99	4.43E−	case-	dom	CVD
  	15250				01	only		83				02	only
  	rs46-	1.45	1.08	1.93	1.28E−	case-	39/98/54	44/123/	1.20	0.91	1.57	2.00E−	case-	add	CVD
  	89078				02	only		85				01	only
  	rs286-	0.70	0.50	0.98	3.59E−	case-	7/72/112	21/103/	0.72	0.52	0.99	4.22E−	case-	add	CVD
  	9680				02	only		128				02	only
  	rs122-	2.30	0.93	5.69	7.06E−	case-	1/18/172	1/13/236	2.05	0.92	4.57	8.07E−	case-	dom	CVD
  	86877				02	only						02	only
  	rs104-	0.10	0.01	0.75	2.54E−	case-	0/1/190	1/11/240	0.10	0.01	0.85	3.53E−	case-	add	CVD
  	60737				02	only						02	only

• TABLE 7
  			Meta-analysis

  allele

  P

  A1

  allele

  value

  CARE

  WOSCOPS

  	(non-	A2		OR	OR	(ran-	Prava	Placebo		OR	OR			Prava	Placebo
  Marker	ref)	(ref)	OR	L95	U95	dom)	Count	Count	OR	L95	U95	P value	Source	Count	Count
  rs1336-	A	G	1.56	1.28	1.89	7.06E−	306/1284/	152/631/	1.68	1.27	2.22	2.79E−	cohort
  400						06	1371	686				04
  rs1078-	G	A					32/172/	40/162/	1.63	1.22	2.17	8.59E−	Case-	19/81/82	22/91/132
  7944							152	240				04	only
  rs13103-	G	A	0.67	0.54	0.83	2.51E−	81/850/	39/434/	0.70	0.52	0.95	2.39E−	cohort
  899						04	1955	961				02
  rs1312-	G	A					6/91/260	13/147/	0.66	0.49	0.89	7.50E−	Case-	5/53/126	8/83/156
  1569								284				03	only
  rs6563-	A	G	0.64	0.50	0.82	4.51E−	42/350/	35/383/	0.76	0.56	1.04	8.26E−	cohort
  805						04	1102	1052				02
  rs1324-	A	G					5/68/227	9/105/	0.78	0.57	1.06	1.15E−	Case-	2/26/129	4/57/163
  012								268				01	only
  rs1704-	G	T	1.30	1.13	1.50	2.15E−	239/709/	219/690/	1.26	1.03	1.54	2.34E−	cohort
  8681						04	546	562				02
  rs1559-	G	A					55/182/	51/200/	1.34	1.09	1.65	6.39E−	Case-	48/85/51	33/127/87
  557							120	193				03	only
  rs7132-	T	G	0.74	0.65	0.86	3.61E−	341/693/	312/761/	0.75	0.61	0.91	4.20E−	cohort
  840						05	418	361				03
  rs1877-	G	A					59/177/	92/238/	0.75	0.61	0.93	7.37E−	Case-	32/83/69	46/137/64
  527							121	114				03	only
  rs1263-	C	A	0.61	0.45	0.81	7.53E−	235/712/	275/738/	0.54	0.34	0.86	8.70E−	cohort
  5482						04	548	458				03
  rs1917-	A	C					22/152/	70/194/	0.34	0.21	0.57	4.02E−	Case-	27/74/58	50/99/75
  527							126	118				05	only
  rs198-	G	A	1.69	1.34	2.13	1.17E−	340/768/	326/759/	1.58	1.09	2.30	1.68E−	cohort	613/1353/	588/1343/
  476						05	384	385				02		665	710
  rs198-	G	A					74/153/	67/214/	1.57	1.08	2.28	1.90E−	Case-	50/69/40	41/122/61
  462							73	101				02	only
  rs1117-	T	G	0.77	0.67	0.89	2.86E−	259/693/	245/735/	0.76	0.63	0.93	8.77E−	cohort
  8579						04	542	490				03
  rs213-	A	G					51/153/	74/228/	0.74	0.60	0.90	3.60E−	Case-	20/89/75	41/132/74
  2241							153	142				03	only
  rs384-	G	C	0.75	0.65	0.86	4.20E−	321/694/	295/766/	0.73	0.60	0.89	2.08E−	cohort
  4207						05	479	409				03
  rs2270-	G	A					59/165/	93/235/	0.72	0.59	0.88	1.46E−	Case-	28/87/69	45/136/66
  588							133	116				03	only
  rs304-	A	G	2.70	1.54	4.73	5.08E−	61/409/	48/448/	1.95	0.89	4.29	9.56E−	cohort
  597						04	980	938				02
  rs304-	A	G					18/101/	10/144/	2.28	1.03	5.03	4.10E−	Case-	10/55/119	4/75/168
  601							238	290				02	only
  rs1255-	C	A	1.32	1.12	1.56	7.32E−	314/693/	292/668/	1.22	0.98	1.50	7.15E−	cohort
  3453						04	445	473				02
  rs4715-	A	C					70/142/	72/174/	1.26	1.02	1.56	3.39E−	Case-	32/82/45	27/103/94
  79							88	136				02	only
  rs2768-	C	T	1.33	1.14	1.54	1.76E−	261/675/	241/665/	1.22	0.98	1.51	7.06E−	cohort
  652						04	514	527				02
  rs7873-	A	G					70/143/	73/175/	1.25	1.01	1.55	4.05E−	Case-	32/82/45	28/103/93
  371							87	134				02	only
  rs1117-	T	G	0.77	0.67	0.88	2.30E−	259/693/	245/735/	0.76	0.63	0.93	8.77E−	cohort
  8579						04	542	490				03
  rs9325-	A	C					51/154/	74/228/	0.74	0.60	0.91	4.36E−	Case-	20/89/75	41/134/72
  191							152	142				03	only
  rs1094-	T	C	1.59	1.28	1.97	2.76E−	19/277/	23/270/	1.72	1.25	2.36	8.43E−	cohort
  5874						05	1197	1178				04
  rs934-	A	G					7/76/274	4/67/373	1.56	1.12	2.15	7.68E−	Case-	2/42/140	3/45/199
  6951												03	only
  rs1310-	G	T	0.69	0.58	0.83	5.80E−	104/895/	52/452/	0.69	0.53	0.89	4.84E−	cohort
  7334						05	1967	967				03
  rs988-	G	A					6/88/263	13/146/	0.66	0.50	0.87	3.02E−	Case-	5/53/126	9/82/156
  146								285				03	only

  WOSCOPS

  PROVEIT

  		OR	OR	P		Atorv	Prav		OR	OR	P		Mod-	End-
  Marker	OR	L95	U95	value	Source	Count	Count	OR	L95	U95	value	Source	el	point
  rs1336-						151/404/	116/431/	1.46	1.00	2.12	4.82E−	cohort	dom	CVD
  400						459	465				02
  rs1078-	1.45	0.99	2.14	5.84E−	Case-	29/84/77	29/101/	1.37	0.93	2.01	1.15E−	Case-	dom	CVD
  7944				02	only		122				01	only
  rs13103-													dom	CVD
  899
  rs1312-	0.78	0.52	1.17	2.32E−	Case-	6/38/147	7/84/161	0.52	0.34	0.80	3.10E−	Case-	dom	CVD
  1569				01	only						03	only
  rs6563-													add	CHD
  805
  rs1324-	0.60	0.38	0.96	3.12E−	Case-	3/30/158	10/68/	0.51	0.34	0.76	1.08E−	Case-	add	CHD
  012				02	only		174				03	only
  rs1704-													add	CVD
  8681
  rs1559-	1.53	1.16	2.02	2.89E−	Case-	32/83/76	30/114/	1.19	0.90	1.56	2.26E−	Case-	add	CVD
  557				03	only		108				01	only
  rs7132-													add	CVD
  840
  rs1877-	0.77	0.58	1.02	6.90E−	Case-	31/93/67	64/117/	0.72	0.55	0.94	1.70E−	Case-	add	CVD
  527				02	only		71				02	only
  rs1263-													rec	CHD
  5482
  rs1917-	0.73	0.44	1.24	2.46E−	Case-	22/98/70	48/117/	0.57	0.33	1.00	4.86E−	Case-	rec	CHD
  527				01	only		87				02	only
  rs198-	1.61	1.06	2.46	2.63E−	cohort								rec	CHD
  476				02
  rs198-	2.12	1.31	3.42	2.23E−	Case-	67/83/41	55/132/	1.92	1.26	2.94	2.58E−	Case-	rec	CHD
  462				03	only		65				03	only
  rs1117-						162/444/	177/462/	0.85	0.65	1.10	2.20E−	cohort	add	CVD
  8579						403	365				01
  rs213-	0.70	0.52	0.94	1.66E−	Case-	26/87/78	45/121/	0.79	0.60	1.04	9.47E−	Case-	add	CVD
  2241				02	only		86				02	only
  rs384-						190/491/	235/471/	0.78	0.60	1.01	5.47E−	cohort	add	CVD
  4207						336	306				02
  rs2270-	0.75	0.57	1.00	5.34E−	Case-	30/93/68	62/122/	0.70	0.53	0.92	1.07E−	Case-	add	CVD
  588				02	only		68				02	only
  rs304-													rec	CVD
  597
  rs304-	3.93	1.20	12.87	2.38E−	Case-	13/52/	6/70/176	3.63	1.24	10.64	1.88E−	Case-	rec	CVD
  601				02	only	126					02	only
  rs1255-													add	CHD
  3453
  rs4715-	1.62	1.20	2.19	1.84E−	Case-	48/80/63	35/132/	1.27	0.97	1.66	8.39E−	Case-	add	CHD
  79				03	only		85				02	only
  rs2768-													add	CHD
  652
  rs7873-	1.59	1.17	2.15	2.68E−	Case-	47/82/62	35/129/	1.31	1.00	1.71	5.23E−	Case-	add	CHD
  371				03	only		88				02	only
  rs1117-						162/444/	177/462/	0.85	0.65	1.10	2.20E−	cohort	add	CVD
  8579						403	365				01
  rs9325-	0.69	0.51	0.92	1.19E−	Case-	26/86/79	45/121/	0.78	0.59	1.03	7.96E−	Case-	add	CVD
  191				02	only		86				02	only
  rs1094-						22/196/	20/201/	1.72	1.15	2.58	8.16E−	cohort	add	CVD
  5874						799	795				03
  rs934-	1.25	0.81	1.92	3.09E−	Case-	5/45/141	0/43/	1.88	1.22	2.91	4.63E−	Case-	add	CVD
  6951				01	only		209				03	only
  rs1310-						46/286/	37/293/	0.60	0.43	0.86	4.97E−	cohort	add	CVD
  7334						687	683				03
  rs988-	0.80	0.56	1.14	2.15E−	Case-	6/37/148	7/80/	0.64	0.44	0.93	2.04E−	Case-	add	CVD
  146				01	only		165				02	only

• 	TABLE 8
  	Original SNP	Genotyped SNP
  	(rs #)	(rs #)	LD (r{circumflex over ( )}2)
  	rs10193722	rs11124322	1
  	rs1051334	rs1051344	0.9637
  	rs10740308	rs2030057	0.9457
  	rs10831415	rs10831416	1
  	rs1229430	rs4657668	0.9445
  	rs12914132	rs6497117	0.9642
  	rs1594887	rs1529806	1
  	rs16861476	rs3732788	1
  	rs1737478	rs1773549	1
  	rs2196180	rs1560901	1
  	rs231358	rs231355	0.9636
  	rs2335451	rs10875941	1
  	rs2358931	rs9834251	0.8864
  	rs2593270	rs4765531	1
  	rs2656824	rs4765531	1
  	rs302296	rs302290	1
  	rs3793048	rs3806005	1
  	rs3861810	rs1560901	1
  	rs4128766	rs7179134	0.951
  	rs4242084	rs2148575	1
  	rs4328731	rs5756670	1
  	rs4980176	rs7094941	1
  	rs6550706	rs1851830	1
  	rs6950121	rs10275879	1
  	rs7751843	rs7765440	1
  	rs7901888	rs2030057	1
  	rs7913568	rs3998860	0.9736
  	rs9467561	rs6931627	1
  	rs9554735	rs912366	0.9646
  	rs10787944	rs1336400	1
  	rs13121569	rs13103899	1
  	rs1324012	rs6563805	1
  	rs1559557	rs17048681	0.8814
  	rs1877527	rs7132840	0.9591
  	rs1917527	rs12635482	0.9293
  	rs198462	rs198476	0.9823
  	rs2132241	rs11178579	1
  	rs2270588	rs3844207	1
  	rs304601	rs304597	0.9732
  	rs471579	rs12553453	0.931
  	rs7873371	rs2768652	0.8956
  	rs9325191	rs11178579	1
  	rs9346951	rs10945874	0.9567
  	rs988146	rs13107334	0.9491

• TABLE 9
  														PLA-	PRA-	PRA-	PRA-	PLA-	PLA-	PLA-
  		AL-									HW_	ALL-	PRAVA_	CEBO_	VA_	VA_	VA_	CEBO_	CEBO_	CEBO_
  		LELE	MOD-	N-							PVAL	ELE_F	ALLELE_	ALLELE_	A1_HZ_	HET_	A2_HZ_	A1_HZ_	HET_	A2_HZ_
  SNP rs #	SOURCE	(A1)	EL	MISS	OR	SE	L95	U95	STAT	P	UE	REQ	FREQ	FREQ	COUNT	COUNT	COUNT	COUNT	COUNT	COUNT

  rs198460	Genotyped	G	REC	682	1.552	0.1926	1.064	2.264	2.284	0.02238	0.02592	0.47507	0.50167	0.4542	73	155	72	66	215	101
  rs603940	Genotyped	G	REC	682	0.614	0.2233	0.3962	0.9509	−2.185	0.02885	0.812	0.40469	0.38833	0.4175	38	157	105	72	175	135
  rs10021016	Genotyped	G	GEN	682					7.495	0.02358	0.8438	0.26393	0.29667	0.2382	29	120	151	17	148	217
  rs1003148	Imputed	C	ADD	674	0.691	0.1112	0.5556	0.8592	−3.325	0.000885	0.04475	0.40059	0.34783	0.4427	38	132	129	83	166	126
  rs1003148	Imputed	C	GEN	674					11.71	0.002865	0.04475	0.40059	0.34783	0.4427	38	132	129	83	166	126
  rs1003148	Imputed	C	REC	674	0.511	0.2158	0.3345	0.7794	−3.115	0.001839	0.04475	0.40059	0.34783	0.4427	38	132	129	83	166	126
  rs10046799	Imputed	C	ADD	671	0.784	0.1099	0.6321	0.9726	−2.212	0.02694	0.1595	0.55365	0.52055	0.5792	82	140	70	133	173	73
  rs10046799	Imputed	C	GEN	671					4.972	0.08326	0.1595	0.55365	0.52055	0.5792	82	140	70	133	173	73
  rs10051148	Imputed	C	DOM	681	0.561	0.1597	0.4104	0.7675	−3.617	0.000298	0.9326	0.34728	0.30833	0.378	36	113	151	45	198	138
  rs10054055	Imputed	T	DOM	681	0.561	0.1597	0.4104	0.7675	−3.617	0.000298	0.9326	0.34728	0.30833	0.378	36	113	151	45	198	138
  rs10067895	Imputed	A	DOM	672	0.561	0.1605	0.4097	0.7686	−3.6	0.000319	0.9321	0.34598	0.3064	0.3773	36	110	151	45	193	137
  rs1008705	Imputed	C	DOM	505	1.49	0.1837	1.04	2.136	2.172	0.02985	0.9137	0.28812	0.3211	0.2631	21	98	99	20	111	156
  rs10105871	Imputed	C	DOM	592	1.731	0.1743	1.23	2.436	3.149	0.001636	0.2592	0.38429	0.42278	0.3544	42	135	82	52	132	149
  rs10116807	Imputed	A	GEN	652					8.336	0.01548	1	0.22469	0.25087	0.2041	23	98	166	10	129	226
  rs10116807	Imputed	A	REC	652	3.065	0.389	1.43	6.569	2.88	0.003983	1	0.22469	0.25087	0.2041	23	98	166	10	129	226
  rs10121941	Imputed	C	DOM	682	0.529	0.2074	0.352	0.7937	−3.074	0.00211	0.6748	0.10191	0.07333	0.1243	2	40	258	6	83	293
  rs10128638	Genotyped	G	DOM	682	0.575	0.1787	0.4054	0.8167	−3.094	0.001978	0.9389	0.49047	0.45167	0.5209	66	139	95	97	204	81
  rs1012924	Imputed	G	ADD	682	0.518	0.1922	0.3551	0.7544	−3.426	0.000612	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs1012924	Imputed	G	DOM	682	0.474	0.2097	0.3145	0.7155	−3.556	0.000376	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs1016030	Genotyped	G	ADD	680	1.4	0.1137	1.12	1.749	2.956	0.00312	0.6897	0.40074	0.44482	0.3661	61	144	94	51	177	153
  rs1016030	Genotyped	G	GEN	680					8.902	0.01167	0.6897	0.40074	0.44482	0.3661	61	144	94	51	177	153
  rs1017558	Imputed	A	REC	668	1.905	0.2304	1.213	2.992	2.798	0.005138	0.4004	0.35853	0.36735	0.3516	52	112	130	39	185	150
  rs10183431	Imputed	T	DOM	677	1.604	0.1584	1.176	2.188	2.983	0.002854	0.06064	0.24372	0.27534	0.2192	14	135	147	17	133	231
  rs10195401	Imputed	C	DOM	671	1.633	0.1636	1.185	2.251	2.998	0.002721	0.9348	0.38227	0.41723	0.3547	45	157	94	52	162	161
  rs10239416	Imputed	A	DOM	658	0.618	0.1624	0.4496	0.8497	−2.963	0.003046	0.8667	0.36702	0.32653	0.3997	34	124	136	53	185	126
  rs1032188	Imputed	G	GEN	682					6.08	0.04784	1	0.30352	0.27167	0.3285	20	123	157	43	165	174
  rs1032188	Imputed	G	REC	682	0.55	0.2837	0.3157	0.9599	−2.104	0.03536	1	0.30352	0.27167	0.3285	20	123	157	43	165	174
  rs10468988	Imputed	G	ADD	679	1.579	0.1261	1.233	2.022	3.624	0.00029	0.6914	0.26068	0.30936	0.2224	30	125	144	18	133	229
  rs10478919	Imputed	G	DOM	681	0.551	0.1595	0.4029	0.753	−3.738	0.000186	1	0.34802	0.30667	0.3806	36	112	152	46	198	137
  rs10506623	Imputed	C	DOM	682	0.591	0.1642	0.4287	0.8159	−3.199	0.001378	0.8737	0.40176	0.36667	0.4293	46	128	126	65	198	119
  rs10506626	Imputed	A	DOM	682	0.565	0.1629	0.4107	0.7779	−3.501	0.000463	0.9364	0.40029	0.36667	0.4267	49	122	129	61	204	117
  rs10509477	Imputed	T	DOM	682	1.772	0.1576	1.301	2.413	3.63	0.000284	1	0.29692	0.335	0.267	26	149	125	34	136	212
  rs10511071	Imputed	C	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs10511072	Imputed	G	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs10511199	Imputed	C	ADD	679	1.5	0.1343	1.153	1.952	3.019	0.00254	1	0.21944	0.25671	0.1903	21	111	166	11	123	247
  rs10513283	Imputed	G	GEN	680					13.78	0.001017	0.06901	0.19706	0.2408	0.1627	26	92	181	8	108	265
  rs10520072	Imputed	T	DOM	681	0.561	0.1597	0.4104	0.7675	−3.617	0.000298	0.9326	0.34728	0.30833	0.378	36	113	151	45	198	138
  rs1065639	Imputed	C	DOM	645	1.663	0.1678	1.197	2.311	3.031	0.002438	0.3536	0.37132	0.40071	0.3485	35	156	91	48	157	158
  rs10733846	Imputed	G	ADD	676	0.554	0.146	0.4165	0.7381	−4.04	5.35E−05	0.02372	0.19009	0.1388	0.2308	5	73	221	29	116	232
  rs10733846	Imputed	G	DOM	676	0.557	0.1721	0.3978	0.7808	−3.398	0.000679	0.02372	0.19009	0.1388	0.2308	5	73	221	29	116	232
  rs10737390	Imputed	T	DOM	678	0.561	0.161	0.4094	0.7694	−3.588	0.000333	0.4645	0.38274	0.33833	0.418	42	119	139	62	192	124
  rs10749293	Imputed	G	DOM	682	1.794	0.1572	1.319	2.442	3.72	0.000199	1	0.29252	0.33167	0.2618	25	149	126	33	134	215
  rs10752159	Imputed	G	DOM	676	1.431	0.1604	1.045	1.96	2.234	0.02545	1	0.21598	0.24329	0.1944	16	113	169	15	117	246
  rs10753760	Imputed	T	ADD	650	1.411	0.1167	1.122	1.773	2.949	0.003192	0.6867	0.41692	0.46466	0.3801	61	141	81	49	181	137
  rs10753760	Imputed	T	GEN	650					9.074	0.01071	0.6867	0.41692	0.46466	0.3801	61	141	81	49	181	137
  rs10757887	Imputed	C	DOM	677	0.616	0.1602	0.4502	0.8435	−3.023	0.002503	0.8353	0.24446	0.21477	0.2678	18	92	188	21	161	197
  rs10758326	Imputed	A	ADD	679	0.73	0.1149	0.5831	0.9149	−2.734	0.006266	0.7443	0.37923	0.33893	0.4108	32	138	128	68	177	136
  rs10758326	Imputed	A	GEN	679					8.015	0.01818	0.7443	0.37923	0.33893	0.4108	32	138	128	68	177	136
  rs10758326	Imputed	A	REC	679	0.554	0.2314	0.3523	0.8726	−2.549	0.01081	0.7443	0.37923	0.33893	0.4108	32	138	128	68	177	136
  rs10762236	Genotyped	G	ADD	682	0.583	0.1422	0.4409	0.77	−3.797	0.000146	0.0221	0.19941	0.15	0.2382	7	76	217	30	122	230
  rs10765769	Imputed	C	ADD	676	1.445	0.1127	1.159	1.802	3.266	0.001089	0.6368	0.42456	0.47475	0.3852	66	150	81	59	174	146
  rs10765769	Imputed	C	GEN	676					10.87	0.004364	0.6368	0.42456	0.47475	0.3852	66	150	81	59	174	146
  rs10784891	Imputed	C	ADD	656	0.692	0.117	0.5504	0.8705	−3.146	0.001655	0.5819	0.45503	0.40972	0.4905	49	138	101	83	195	90
  rs10784891	Imputed	C	DOM	656	0.57	0.1761	0.4039	0.8053	−3.19	0.001424	0.5819	0.45503	0.40972	0.4905	49	138	101	83	195	90
  rs10787923	Imputed	G	DOM	672	1.834	0.1588	1.343	2.504	3.819	0.000134	1	0.29464	0.33502	0.2627	25	149	123	33	131	211
  rs10787949	Imputed	A	DOM	682	1.79	0.1585	1.312	2.442	3.671	0.000241	1	0.30132	0.34	0.2709	27	150	123	35	137	210
  rs10787951	Imputed	G	DOM	682	1.79	0.1585	1.312	2.442	3.671	0.000241	1	0.30132	0.34	0.2709	27	150	123	35	137	210
  rs10787983	Imputed	C	DOM	682	1.786	0.1574	1.312	2.431	3.685	0.000229	1	0.29545	0.335	0.2644	26	149	125	33	136	213
  rs10788380	Imputed	C	ADD	675	1.411	0.1153	1.125	1.769	2.984	0.002844	0.2184	0.49333	0.53716	0.4591	78	162	56	78	192	109
  rs10788380	Imputed	C	DOM	675	1.762	0.1889	1.217	2.552	2.999	0.002704	0.2184	0.49333	0.53716	0.4591	78	162	56	78	192	109
  rs10788380	Imputed	C	GEN	675					9.862	0.007218	0.2184	0.49333	0.53716	0.4591	78	162	56	78	192	109
  rs10814418	Imputed	G	DOM	680	0.533	0.2074	0.3547	0.7998	−3.037	0.002389	0.6755	0.10221	0.07383	0.1243	2	40	256	6	83	293
  rs10831417	Imputed	A	ADD	674	1.436	0.1147	1.147	1.798	3.154	0.001613	0.8092	0.39688	0.44463	0.359	61	143	94	47	176	153
  rs10831417	Imputed	A	GEN	674					10.39	0.005538	8.09E−01	0.39688	0.44463	0.359	61	143	94	47	176	153
  rs10831422	Imputed	C	ADD	676	1.421	0.1143	1.135	1.777	3.071	0.002131	0.8726	0.39941	0.44631	0.3624	61	144	93	48	178	152
  rs10831422	Imputed	C	GEN	676					9.86	0.007226	0.8726	0.39941	0.44631	0.3624	61	144	93	48	178	152
  rs10862931	Imputed	C	GEN	676					12.36	0.002073	0.2988	0.33284	0.28885	0.3671	21	129	146	60	159	161
  rs10865197	Imputed	C	DOM	679	1.604	0.1581	1.177	2.186	2.988	0.002806	0.04888	0.24448	0.27609	0.2199	14	136	147	17	134	231
  rs10871302	Imputed	A	DOM	677	1.561	0.1787	1.099	2.215	2.49	0.01276	0.5241	0.13959	0.16498	0.1197	8	82	207	7	77	296
  rs10877463	Imputed	C	DOM	681	0.735	0.1583	0.5392	1.003	−1.941	0.05228	0.1829	0.35756	0.34281	0.3691	45	115	139	50	182	150
  rs10877468	Imputed	C	DOM	681	0.745	0.1584	0.5465	1.017	−1.855	0.06358	0.2438	0.35756	0.34448	0.3678	45	116	138	49	183	150
  rs10879240	Imputed	C	ADD	561	0.604	0.1586	0.4424	0.824	−3.18	0.001472	1.43E−14	0.34581	0.30632	0.3782	6	143	104	21	191	96
  rs10879242	Imputed	A	DOM	600	0.502	0.1832	0.3504	0.7186	−3.764	0.000167	1	0.45083	0.41098	0.4821	52	113	99	70	184	82
  rs10879245	Imputed	G	DOM	600	0.502	0.1832	0.3504	0.7186	−3.764	0.000167	1	0.45083	0.41098	0.4821	52	113	99	70	184	82
  rs10879249	Imputed	T	DOM	676	0.583	0.1653	0.4214	0.8058	−3.266	0.001091	0.9363	0.40385	0.36745	0.4325	46	127	125	65	197	116
  rs10886452	Imputed	A	DOM	682	1.79	0.1585	1.312	2.442	3.671	0.000241	1	0.30132	0.34	0.2709	27	150	123	35	137	210
  rs10886463	Imputed	C	DOM	682	1.79	0.1585	1.312	2.442	3.671	0.000241	1	0.30132	0.34	0.2709	27	150	123	35	137	210
  rs10886465	Imputed	A	DOM	682	1.778	0.1589	1.302	2.427	3.622	0.000293	0.9278	0.30279	0.34	0.2736	27	150	123	36	137	209
  rs10886526	Imputed	C	DOM	681	1.762	0.1577	1.293	2.4	3.591	0.000329	1	0.29589	0.33278	0.267	25	149	125	34	136	212
  rs10902437	Imputed	G	ADD	658	1.415	0.1115	1.137	1.761	3.113	0.001853	0.03266	0.38754	0.43857	0.3466	61	135	97	51	151	163
  rs10941126	Imputed	G	ADD	682	0.187	0.4378	0.0793	0.441	−3.83	0.000128	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs10941126	Imputed	G	DOM	682	0.19	0.451	0.0786	0.4606	−3.679	0.000234	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs10947871	Imputed	A	DOM	682	1.569	0.1754	1.112	2.213	2.567	0.01026	0.1579	0.14223	0.16667	0.123	5	90	205	4	86	292
  rs10972978	Imputed	G	DOM	658	0.518	0.2117	0.3418	0.7839	−3.11	0.001873	0.6698	0.10258	0.07292	0.1257	2	38	248	6	81	283
  rs10973012	Imputed	A	DOM	682	0.529	0.2074	0.352	0.7937	−3.074	0.00211	0.6748	0.10191	0.07333	0.1243	2	40	258	6	83	293
  rs10974028	Genotyped	G	ADD	682	0.605	0.1547	0.4467	0.8194	−3.247	0.001165	0.3256	0.16349	0.125	0.1937	9	57	234	13	122	247
  rs10974028	Genotyped	G	DOM	682	0.516	0.1777	0.3642	0.7308	−3.725	0.000196	0.3256	0.16349	0.125	0.1937	9	57	234	13	122	247
  rs11021302	Imputed	A	ADD	681	1.413	0.1142	1.13	1.768	3.029	0.002455	0.873	0.39794	0.44333	0.3622	61	144	95	48	180	153
  rs11021302	Imputed	A	GEN	681					9.725	0.007733	0.873	0.39794	0.44333	0.3622	61	144	95	48	180	153
  rs11099644	Imputed	G	REC	668	1.905	0.2304	1.213	2.992	2.798	0.005138	0.4004	0.35853	0.36735	0.3516	52	112	130	39	185	150
  rs11138315	Imputed	G	ADD	646	0.682	0.1861	0.4732	0.9815	−2.06	0.03937	0.2275	0.11068	0.09123	0.126	3	46	236	8	75	278
  rs11149802	Imputed	T	DOM	677	1.561	0.1787	1.099	2.215	2.49	0.01276	0.5241	0.13959	0.16498	0.1197	8	82	207	7	77	296
  rs1116596	Imputed	T	DOM	681	0.551	0.1595	0.4029	0.753	−3.738	0.000186	1	0.34802	0.30667	0.3806	36	112	152	46	198	137
  rs11178531	Imputed	A	ADD	678	0.722	0.1139	0.5774	0.9022	−2.863	0.004194	0.7006	0.47788	0.43624	0.5105	60	140	98	92	204	84
  rs11178531	Imputed	A	DOM	678	0.557	0.1766	0.3942	0.7879	−3.31	0.000934	0.7006	0.47788	0.43624	0.5105	60	140	98	92	204	84
  rs11178575	Imputed	C	GEN	679					9.118	0.01047	0.5966	0.31885	0.35067	0.294	44	121	133	28	168	185
  rs11178575	Imputed	C	REC	679	2.174	0.2571	1.313	3.598	3.019	0.002532	0.5966	0.31885	0.35067	0.294	44	121	133	28	168	185
  rs11178577	Imputed	T	GEN	680					9.117	0.01048	0.6589	0.31912	0.35067	0.2945	44	121	133	28	169	185
  rs11178577	Imputed	T	REC	680	2.173	0.2571	1.313	3.597	3.019	0.002537	0.6589	0.31912	0.35067	0.2945	44	121	133	28	169	185
  rs11178583	Imputed	A	DOM	665	0.567	0.1672	0.4082	0.7862	−3.399	0.000677	1	0.40827	0.37113	0.4372	46	124	121	65	197	112
  rs11178589	Imputed	T	DOM	678	0.593	0.1662	0.4283	0.8217	−3.142	0.001679	1	0.41593	0.3796	0.4446	48	131	120	69	199	111
  rs11178594	Imputed	C	DOM	680	0.579	0.1651	0.4187	0.7999	−3.312	0.000926	0.9365	0.40294	0.36745	0.4306	46	127	125	65	199	118
  rs11178602	Imputed	T	DOM	680	0.57	0.165	0.4126	0.788	−3.404	0.000665	0.8735	0.40221	0.36577	0.4306	46	126	126	65	199	118
  rs11178648	Imputed	T	DOM	680	0.564	0.1631	0.4095	0.7761	−3.514	0.000442	0.8107	0.40074	0.36622	0.4278	49	121	129	62	202	117
  rs11198877	Imputed	T	DOM	682	1.79	0.1585	1.312	2.442	3.671	0.000241	1	0.30132	0.34	0.2709	27	150	123	35	137	210
  rs11198942	Imputed	T	DOM	680	1.797	0.1579	1.319	2.449	3.712	0.000206	1	0.29706	0.33612	0.2664	26	149	124	34	135	212
  rs11221075	Imputed	A	ADD	674	0.628	0.1738	0.4466	0.8827	−2.678	0.007404	0.4847	0.12685	0.09966	0.1481	1	57	238	12	88	278
  rs11242020	Imputed	T	DOM	682	0.548	0.1595	0.4011	0.7494	−3.769	0.000164	0.9329	0.34824	0.30667	0.3809	36	112	152	46	199	137
  rs11242021	Imputed	T	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.9329	0.34824	0.30833	0.3796	36	113	151	46	198	138
  rs11242022	Imputed	T	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.9329	0.34824	0.30833	0.3796	36	113	151	46	198	138
  rs11242023	Imputed	T	DOM	682	0.564	0.1596	0.4123	0.7707	−3.592	0.000328	1	0.34531	0.30667	0.3757	36	112	152	45	197	140
  rs1149350	Imputed	A	DOM	680	1.537	0.1609	1.121	2.106	2.672	0.007551	0.1324	0.21029	0.23913	0.1877	11	121	167	12	119	250
  rs1150143	Imputed	G	DOM	658	1.631	0.1628	1.186	2.245	3.007	0.002639	0.1849	0.32827	0.35366	0.3086	23	157	107	40	149	182
  rs11576627	Imputed	T	ADD	682	1.785	0.1742	1.268	2.511	3.325	0.000885	0.05306	0.12463	0.15833	0.0982	3	89	208	2	71	309
  rs11576627	Imputed	T	DOM	682	1.844	0.1815	1.292	2.632	3.373	0.000744	0.05306	0.12463	0.15833	0.0982	3	89	208	2	71	309
  rs11602189	Imputed	A	DOM	677	0.604	0.1575	0.4435	0.8223	−3.203	0.001362	0.5429	0.32939	0.2862	0.3632	29	112	156	48	180	152
  rs11605163	Imputed	A	DOM	679	2.068	0.229	1.32	3.239	3.173	0.001509	0.7687	0.07143	0.09532	0.0526	2	53	244	2	36	342
  rs11615214	Imputed	G	ADD	660	0.645	0.1143	0.5156	0.807	−3.837	0.000125	0.02544	0.37652	0.31507	0.4253	31	122	139	76	161	131
  rs11615214	Imputed	G	GEN	660					15.05	0.000541	0.02544	0.37652	0.31507	0.4253	31	122	139	76	161	131
  rs11642394	Imputed	C	DOM	677	1.561	0.1787	1.099	2.215	2.49	0.01276	0.5241	0.13959	0.16498	0.1197	8	82	207	7	77	296
  rs11644943	Imputed	A	ADD	655	1.327	0.1361	1.017	1.733	2.081	0.03739	0.6522	0.22214	0.24829	0.2011	21	103	168	9	128	226
  rs11656608	Imputed	T	DOM	681	0.649	0.1794	0.4567	0.9228	−2.408	0.01605	1	0.14317	0.12375	0.1584	8	58	233	6	109	267
  rs11661309	Imputed	A	ADD	676	0.626	0.1446	0.4718	0.8317	−3.234	0.00122	0.6206	0.19231	0.15152	0.2243	7	76	214	20	130	229
  rs11661309	Imputed	A	DOM	676	0.601	0.1674	0.4325	0.8338	−3.046	0.002323	0.6206	0.19231	0.15152	0.2243	7	76	214	20	130	229
  rs11666131	Imputed	A	ADD	675	1.512	0.136	1.158	1.974	3.04	0.002366	0.4389	0.22444	0.26102	0.1961	20	114	161	10	129	241
  rs11743355	Imputed	C	ADD	650	0.164	0.4716	0.0652	0.4139	−3.83	0.000128	0.05102	0.03692	0.01394	0.0551	0	8	279	3	34	326
  rs11743355	Imputed	C	DOM	650	0.166	0.4861	0.064	0.4303	−3.695	0.00022	0.05102	0.03692	0.01394	0.0551	0	8	279	3	34	326
  rs11746806	Imputed	T	ADD	682	0.217	0.4129	0.0965	0.4867	−3.704	0.000213	0.06816	0.03812	0.01667	0.055	0	10	290	3	36	343
  rs11746806	Imputed	T	DOM	682	0.223	0.4255	0.0967	0.5123	−3.532	0.000412	0.06816	0.03812	0.01667	0.055	0	10	290	3	36	343
  rs11746959	Imputed	T	ADD	682	0.187	0.4378	0.0793	0.441	−3.83	0.000128	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs11746959	Imputed	T	DOM	682	0.19	0.451	0.0786	0.4606	−3.679	0.000234	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs11749272	Imputed	T	DOM	679	0.552	0.16	0.4036	0.7559	−3.709	0.000208	1	0.34831	0.30705	0.3806	36	111	151	46	198	137
  rs11901899	Imputed	A	DOM	668	1.459	0.1585	1.069	1.99	2.382	0.0172	1	0.26422	0.29223	0.2419	22	129	145	24	132	216
  rs11926319	Imputed	G	ADD	675	0.479	0.2053	0.3205	0.7167	−3.583	0.00034	0.8261	0.09778	0.06397	0.1243	1	36	260	6	82	290
  rs11926319	Imputed	G	DOM	675	0.466	0.2155	0.3052	0.7104	−3.546	0.000391	0.8261	0.09778	0.06397	0.1243	1	36	260	6	82	290
  rs11956952	Imputed	C	DOM	671	0.633	0.1593	0.4632	0.8648	−2.872	0.00408	0.7761	0.28465	0.24662	0.3147	21	104	171	35	166	174
  rs12025826	Imputed	G	DOM	664	1.73	0.166	1.249	2.395	3.3	0.000968	0.05275	0.40286	0.45313	0.3644	61	139	88	59	156	161
  rs1204522	Imputed	C	GEN	676					11.67	0.002917	0.87	0.37796	0.33054	0.4153	27	143	128	68	178	132
  rs1204524	Imputed	A	GEN	678					11.89	0.002625	0.8065	0.37832	0.33054	0.4158	27	143	128	68	180	132
  rs12153185	Imputed	T	DOM	672	0.561	0.1605	0.4097	0.7686	−3.6	0.000319	0.9321	0.34598	0.3064	0.3773	36	110	151	45	193	137
  rs12182651	Imputed	T	ADD	678	2.104	0.213	1.386	3.194	3.492	0.000479	0.6166	0.08481	0.11371	0.062	3	62	234	3	41	335
  rs12182651	Imputed	T	DOM	678	2.304	0.2264	1.478	3.592	3.687	0.000227	0.6166	0.08481	0.11371	0.062	3	62	234	3	41	335
  rs12193568	Imputed	G	DOM	565	1.551	0.1819	1.086	2.215	2.413	0.01581	0.3148	0.17788	0.20751	0.1538	8	89	156	6	84	222
  rs12264914	Imputed	C	DOM	361	0.591	0.2158	0.3873	0.9024	−2.436	0.01486	0.08135	0.34349	0.29063	0.3856	17	59	84	33	89	79
  rs12307767	Imputed	C	DOM	661	0.729	0.1608	0.532	0.9993	−1.964	0.04953	0.2737	0.36157	0.34589	0.374	44	114	134	49	178	142
  rs1232298	Imputed	G	REC	658	1.65	0.2751	0.9623	2.829	1.82	0.06874	0.2441	0.31839	0.32118	0.3162	33	119	136	27	180	163
  rs12407412	Imputed	C	ADD	682	1.785	0.1742	1.268	2.511	3.325	0.000885	0.05306	0.12463	0.15833	0.0982	3	89	208	2	71	309
  rs12407412	Imputed	C	DOM	682	1.844	0.1815	1.292	2.632	3.373	0.000744	0.05306	0.12463	0.15833	0.0982	3	89	208	2	71	309
  rs12420184	Imputed	G	DOM	681	0.542	0.1789	0.3816	0.7695	−3.424	0.000617	0.4694	0.15639	0.125	0.1811	9	57	234	10	118	253
  rs12422750	Imputed	A	DOM	679	0.756	0.1585	0.5538	1.031	−1.769	0.07688	0.1821	0.35935	0.34564	0.3701	45	116	137	51	180	150
  rs12446951	Imputed	A	ADD	520	2.018	0.2623	1.207	3.375	2.678	0.007409	0.4988	0.06923	0.09389	0.0498	1	41	187	0	29	262
  rs12446951	Imputed	A	DOM	520	2.001	0.2641	1.192	3.358	2.626	0.008639	0.4988	0.06923	0.09389	0.0498	1	41	187	0	29	262
  rs12457400	Imputed	G	DOM	680	0.553	0.201	0.3727	0.8196	−2.95	0.003178	0.6917	0.10882	0.08361	0.1286	4	42	253	5	88	288
  rs1247340	Imputed	C	DOM	680	1.537	0.1609	1.121	2.106	2.672	0.007551	0.1324	0.21029	0.23913	0.1877	11	121	167	12	119	250
  rs1247341	Imputed	C	DOM	680	1.537	0.1609	1.121	2.106	2.672	0.007551	0.1324	0.21029	0.23913	0.1877	11	121	167	12	119	250
  rs12521291	Imputed	G	ADD	673	0.684	0.1186	0.5424	0.8634	−3.198	0.001382	0.4434	0.34398	0.30034	0.3787	28	123	147	56	172	147
  rs12526849	Imputed	T	ADD	656	1.462	0.113	1.172	1.825	3.364	0.000769	0.2246	0.40473	0.45819	0.3631	63	137	87	52	164	153
  rs12526849	Imputed	T	GEN	656					11.33	0.003474	0.2246	0.40473	0.45819	0.3631	63	137	87	52	164	153
  rs12543110	Imputed	G	DOM	681	1.542	0.1596	1.127	2.108	2.712	0.006696	0.106	0.23128	0.25585	0.212	17	119	163	27	108	247
  rs12678600	Imputed	A	DOM	675	0.617	0.1585	0.4524	0.8419	−3.046	0.002319	0.7936	0.32889	0.28859	0.3607	27	118	153	44	184	149
  rs12719415	Imputed	T	DOM	673	0.546	0.1604	0.3989	0.748	−3.771	0.000163	0.548	0.34027	0.29522	0.375	31	111	151	43	199	138
  rs12831292	Imputed	G	DOM	678	0.574	0.1652	0.4153	0.7936	−3.359	0.000782	0.9364	0.40339	0.367	0.4318	46	126	125	65	199	117
  rs12923993	Imputed	C	DOM	677	1.561	0.1787	1.099	2.215	2.49	0.01276	0.5241	0.13959	0.16498	0.1197	8	82	207	7	77	296
  rs12936964	Imputed	T	DOM	673	1.718	0.1622	1.25	2.362	3.338	0.000844	0.6161	0.35958	0.40372	0.3249	45	149	102	45	155	177
  rs12960663	Imputed	G	ADD	672	0.639	0.1447	0.4809	0.8478	−3.101	0.001927	0.5336	0.19122	0.15203	0.2221	7	76	213	20	127	229
  rs13038146	Imputed	C	ADD	681	1.338	0.1141	1.07	1.674	2.554	0.01063	0.2789	0.3583	0.39667	0.3281	54	130	116	40	170	171
  rs13038146	Imputed	C	GEN	681					7.872	0.01953	0.2789	0.3583	0.39667	0.3281	54	130	116	40	170	171
  rs13134222	Imputed	A	GEN	597					9.274	0.009687	0.917	0.26884	0.23408	0.297	10	105	152	32	132	166
  rs13172910	Imputed	A	DOM	675	0.633	0.159	0.4637	0.8646	−2.875	0.004042	0.7779	0.28667	0.25	0.3156	22	105	171	35	168	174
  rs13194907	Imputed	A	ADD	682	2.264	0.2373	1.422	3.606	3.444	0.000573	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs13194907	Imputed	A	DOM	682	2.432	0.2521	1.484	3.986	3.525	0.000423	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs13195745	Imputed	A	ADD	682	2.264	0.2373	1.422	3.606	3.444	0.000573	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs13195745	Imputed	A	DOM	682	2.432	0.2521	1.484	3.986	3.525	0.000423	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs1321432	Imputed	A	REC	681	2.324	0.2254	1.494	3.615	3.741	0.000183	0.5731	0.3884	0.44314	0.3455	60	145	94	39	186	157
  rs1321457	Imputed	G	REC	665	2.293	0.2272	1.469	3.58	3.653	0.000259	0.7441	0.38872	0.44178	0.3472	59	140	93	39	181	153
  rs13265054	Imputed	T	DOM	671	0.623	0.1591	0.4561	0.8511	−2.973	0.002945	0.7921	0.32489	0.28716	0.3547	27	116	153	42	182	151
  rs13282131	Imputed	C	GEN	675					7.767	0.02058	0.8765	0.44889	0.48639	0.4199	72	142	80	65	190	126
  rs13353526	Imputed	C	DOM	674	1.752	0.2045	1.174	2.617	2.743	0.006085	0.3687	0.09496	0.11486	0.0794	2	64	230	6	48	324
  rs1336382	Imputed	T	DOM	682	1.772	0.1576	1.301	2.413	3.63	2.84E−04	1	0.29692	0.335	0.267	26	149	125	34	136	212
  rs1336383	Imputed	T	DOM	682	1.772	0.1576	1.301	2.413	3.63	0.000284	1	0.29692	0.335	0.267	26	149	125	34	136	212
  rs1336407	Imputed	T	DOM	682	1.772	0.1576	1.301	2.413	3.63	0.000284	1	0.29692	0.335	0.267	26	149	125	34	136	212
  rs1336409	Imputed	T	DOM	682	1.772	0.1576	1.301	2.413	3.63	0.000284	1	0.29692	0.335	0.267	26	149	125	34	136	212
  rs1336596	Imputed	A	DOM	682	0.565	0.1607	0.412	0.7735	−3.558	0.000374	0.9327	0.34751	0.31333	0.3743	37	114	149	46	194	142
  rs1343560	Imputed	T	ADD	678	0.521	0.1923	0.3575	0.7596	−3.39	0.000699	0.3076	0.10546	0.07239	0.1312	3	37	257	7	86	288
  rs1343560	Imputed	T	DOM	678	0.478	0.2098	0.3168	0.7211	−3.518	0.000435	0.3076	0.10546	0.07239	0.1312	3	37	257	7	86	288
  rs1361987	Imputed	T	GEN	682					12.45	0.001975	0.9355	0.3849	0.335	0.4241	28	145	127	72	180	130
  rs1386153	Imputed	T	ADD	677	0.694	0.1194	0.5493	0.8772	−3.057	0.002235	0.7936	0.32718	0.28261	0.3624	27	115	157	47	180	151
  rs1386153	Imputed	T	DOM	677	0.603	0.1574	0.4431	0.8213	−3.21	0.001326	0.7936	0.32718	0.28261	0.3624	27	115	157	47	180	151
  rs1394015	Imputed	C	DOM	669	1.658	0.1636	1.203	2.285	3.091	0.001993	0.4527	0.36472	0.39384	0.3422	35	160	97	49	160	168
  rs1407038	Imputed	A	REC	678	2.31	0.2263	1.483	3.599	3.7	0.000215	0.8076	0.38422	0.4375	0.3429	59	141	96	39	184	159
  rs1407039	Imputed	A	REC	680	2.185	0.221	1.417	3.37	3.538	4.04E−04	0.748	0.39412	0.44631	0.3534	61	144	93	42	186	154
  rs1412802	Imputed	T	GEN	681					6.558	0.03767	0.785	0.30176	0.27	0.3268	17	128	155	43	163	175
  rs1414865	Imputed	T	DOM	682	1.79	0.1585	1.312	2.442	3.671	0.000241	1	0.30132	0.34	0.2709	27	150	123	35	137	210
  rs1414873	Imputed	A	DOM	682	1.786	0.1574	1.312	2.431	3.685	0.000229	1	0.29545	0.335	0.2644	26	149	125	33	136	213
  rs1414876	Imputed	C	DOM	682	1.786	0.1574	1.312	2.431	3.685	0.000229	1	0.29545	0.335	0.2644	26	149	125	33	136	213
  rs1418671	Imputed	C	REC	655	2.259	0.2305	1.437	3.549	3.534	0.000409	0.2728	0.36336	0.41493	0.3229	57	125	106	36	165	166
  rs1419490	Genotyped	T	GEN	682					12.66	0.001783	0.9357	0.38416	0.33333	0.4241	28	144	128	72	180	130
  rs1434507	Imputed	A	ADD	681	1.547	0.1268	1.206	1.983	3.439	0.000584	0.8411	0.25698	0.30333	0.2205	28	126	146	18	132	231
  rs1434508	Imputed	T	ADD	681	1.536	0.1268	1.198	1.97	3.388	0.000705	0.9202	0.25771	0.30333	0.2218	28	126	146	18	133	230
  rs1435205	Imputed	A	ADD	679	1.5	0.1343	1.153	1.952	3.019	0.00254	1	0.21944	0.25671	0.1903	21	111	166	11	123	247
  rs1443928	Imputed	C	REC	672	0.59	0.1812	0.4133	0.8409	−2.917	0.003539	0.5875	0.53571	0.50169	0.5625	66	165	65	123	177	76
  rs1452235	Imputed	G	GEN	682					12.53	0.001899	0.2617	0.33065	0.28667	0.3652	21	130	149	60	159	163
  rs1452236	Imputed	G	GEN	681					12.63	0.001811	0.2989	0.33113	0.28667	0.3661	21	130	149	60	159	162
  rs1452237	Imputed	G	GEN	682					12.53	0.001899	0.2617	0.33065	0.28667	0.3652	21	130	149	60	159	163
  rs1452243	Genotyped	T	GEN	682					12.53	0.001899	0.2617	0.33065	0.28667	0.3652	21	130	149	60	159	163
  rs1463768	Genotyped	G	REC	682	1.527	0.2037	1.025	2.277	2.08	0.03755	0.3847	0.40982	0.435	0.3901	63	135	102	57	184	141
  rs1463769	Imputed	G	REC	682	1.561	0.2044	1.045	2.33	2.177	0.02947	0.428	0.40836	0.435	0.3874	63	135	102	56	184	142
  rs1472435	Imputed	A	ADD	675	0.581	0.2266	0.3727	0.9061	−2.395	0.01663	0.3725	0.07111	0.05201	0.0862	0	31	267	5	55	317
  rs1472435	Imputed	A	DOM	675	0.6	0.2382	0.376	0.9566	−2.146	0.03185	0.3725	0.07111	0.05201	0.0862	0	31	267	5	55	317
  rs1476714	Imputed	A	DOM	681	0.558	0.1599	0.4076	0.7628	−3.654	0.000258	1	0.34802	0.30769	0.3796	36	112	151	46	198	138
  rs1495159	Imputed	G	ADD	671	0.664	0.125	0.5195	0.8479	−3.281	0.001036	0.8591	0.31967	0.27721	0.3528	19	125	150	48	170	159
  rs1495159	Imputed	G	GEN	671					11.32	0.003475	0.8591	0.31967	0.27721	0.3528	19	125	150	48	170	159
  rs1495375	Imputed	A	DOM	674	0.571	0.1673	0.4111	0.7921	−3.353	0.0008	1	0.42507	0.3902	0.4524	52	127	117	70	202	106
  rs1495376	Imputed	T	DOM	649	0.594	0.1848	0.4134	0.8529	−2.821	0.004787	0.8753	0.4923	0.46986	0.5095	70	125	87	86	202	79
  rs1495377	Imputed	G	DOM	652	0.615	0.1836	0.4294	0.8819	−2.644	0.008185	0.9375	0.49233	0.47183	0.5082	71	126	87	86	202	80
  rs1495381	Imputed	T	GEN	682					10.43	0.005444	0.3777	0.39443	0.43	0.3665	59	140	101	41	198	143
  rs1495381	Imputed	T	REC	682	2.043	0.2213	1.324	3.152	3.229	0.001243	0.3777	0.39443	0.43	0.3665	59	140	101	41	198	143
  rs1498992	Imputed	G	DOM	681	0.583	0.1567	0.4286	0.7922	−3.446	0.000568	0.4296	0.32159	0.27592	0.3573	28	109	162	47	179	156
  rs1499001	Imputed	T	DOM	661	0.587	0.1603	0.4291	0.8042	−3.32	0.000901	0.5609	0.27761	0.22837	0.3159	16	100	173	38	159	175
  rs1512988	Imputed	A	DOM	681	0.588	0.1643	0.4264	0.8118	−3.229	0.001243	0.9365	0.40088	0.36455	0.4293	45	128	126	65	198	119
  rs1512989	Imputed	T	DOM	681	0.588	0.1643	0.4264	0.8118	−3.229	0.001243	0.9365	0.40088	0.36455	0.4293	45	128	126	65	198	119
  rs1512991	Imputed	T	ADD	677	0.734	0.1143	0.5865	0.9181	−2.707	0.006791	0.6434	0.46824	0.42929	0.4987	57	141	99	88	203	89
  rs1512991	Imputed	T	DOM	677	0.588	0.1751	0.4173	0.8289	−3.032	0.002431	0.6434	0.46824	0.42929	0.4987	57	141	99	88	203	89
  rs1516855	Imputed	G	REC	657	1.965	0.2424	1.222	3.16	2.786	0.005328	0.1374	0.38052	0.41176	0.356	49	140	100	37	188	143
  rs1527450	Imputed	T	ADD	670	1.426	0.1148	1.139	1.787	3.093	0.001982	0.7474	0.39776	0.44463	0.3602	61	143	94	47	174	151
  rs1527450	Imputed	T	GEN	670					9.977	0.006814	0.7474	0.39776	0.44463	0.3602	61	143	94	47	174	151
  rs1567740	Imputed	T	DOM	679	0.584	0.165	0.4224	0.8064	−3.264	0.001098	0.8732	0.40206	0.367	0.4293	46	126	125	65	198	119
  rs1572573	Imputed	A	ADD	657	1.745	0.1419	1.321	2.305	3.923	8.73E−05	0.1585	0.18798	0.23693	0.15	16	104	167	13	85	272
  rs1572573	Imputed	A	DOM	657	2.014	0.1694	1.445	2.807	4.132	3.60E−05	0.1585	0.18798	0.23693	0.15	16	104	167	13	85	272
  rs1584003	Imputed	C	DOM	673	1.97	0.1803	1.384	2.806	3.761	0.000169	0.2788	0.47028	0.5119	0.438	70	161	63	86	160	133
  rs1584005	Imputed	C	DOM	665	1.936	0.181	1.358	2.761	3.652	0.000261	0.2759	0.46842	0.50692	0.4388	67	159	63	86	158	132
  rs1585771	Imputed	G	ADD	674	1.481	0.1242	1.161	1.889	3.162	0.001567	0.3712	0.26261	0.30678	0.2282	31	119	145	20	133	226
  rs1592015	Imputed	G	DOM	681	0.523	0.1726	0.373	0.7337	−3.754	0.000174	0.43	0.17621	0.13712	0.2068	10	62	227	14	130	238
  rs1594885	Imputed	A	ADD	681	1.561	0.1254	1.221	1.995	3.551	0.000384	0.6918	0.26211	0.31	0.2244	30	126	144	19	133	229
  rs1603232	Imputed	A	DOM	655	0.631	0.1827	0.4408	0.902	−2.525	0.01159	1	0.48779	0.47038	0.5014	72	126	89	84	201	83
  rs1614565	Imputed	C	DOM	671	0.574	0.1797	0.4034	0.816	−3.091	0.001993	0.9385	0.48957	0.46949	0.5053	75	127	93	85	210	81
  rs1648200	Imputed	G	ADD	623	1.473	0.135	1.13	1.919	2.868	0.004134	0.833	0.25522	0.29478	0.2254	19	120	129	20	120	215
  rs16877387	Imputed	C	GEN	677					11.65	0.002959	0.3017	0.33678	0.38047	0.3026	51	124	122	32	166	182
  rs16877387	Imputed	C	REC	677	2.249	0.2423	1.399	3.616	3.345	0.000823	0.3017	0.33678	0.38047	0.3026	51	124	122	32	166	182
  rs16938626	Imputed	G	DOM	663	0.631	0.1588	0.4625	0.8618	−2.897	0.00377	0.9255	0.29261	0.25676	0.3215	23	106	167	33	170	164
  rs1694334	Imputed	G	ADD	599	0.664	0.1373	0.5072	0.8688	−2.984	0.002847	0.01892	0.24207	0.1954	0.2781	10	82	169	36	116	186
  rs16998821	Imputed	C	DOM	681	0.523	0.1726	0.373	0.7337	−3.754	0.000174	0.43	0.17621	0.13712	0.2068	10	62	227	14	130	238
  rs1700400	Imputed	T	ADD	672	0.695	0.131	0.5378	0.8989	−2.774	0.005544	0.5481	0.25967	0.22297	0.2886	11	110	175	31	155	190
  rs17007620	Imputed	G	ADD	599	1.567	0.1431	1.184	2.074	3.138	0.001699	0.8194	0.23372	0.27308	0.2035	16	110	134	15	108	216
  rs17007620	Imputed	G	DOM	599	1.743	0.171	1.247	2.437	3.251	0.001149	0.8194	0.23372	0.27308	0.2035	16	110	134	15	108	216
  rs17023290	Imputed	C	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs17047957	Imputed	C	DOM	681	1.493	0.168	1.074	2.074	2.384	0.01712	0.4202	0.17181	0.19231	0.1558	7	101	191	16	87	279
  rs1705237	Imputed	A	DOM	666	0.566	0.1803	0.3973	0.8057	−3.158	0.001589	0.8767	0.48649	0.4622	0.5053	71	127	93	85	209	81
  rs1705261	Imputed	A	GEN	682					10.46	0.005353	0.4226	0.39296	0.43	0.3639	59	140	101	41	196	145
  rs1705261	Imputed	A	REC	682	2.043	0.2213	1.324	3.152	3.229	0.001243	0.4226	0.39296	0.43	0.3639	59	140	101	41	196	145
  rs17076972	Imputed	C	ADD	682	1.427	0.1121	1.146	1.778	3.172	0.001511	1	0.47507	0.52667	0.4346	86	144	70	68	196	118
  rs17076972	Imputed	C	GEN	682					11.26	0.003593	1	0.47507	0.52667	0.4346	86	144	70	68	196	118
  rs17076972	Imputed	C	REC	682	1.816	0.1863	1.26	2.616	3.202	0.001365	1	0.47507	0.52667	0.4346	86	144	70	68	196	118
  rs17189710	Imputed	T	ADD	681	1.338	0.1141	1.07	1.674	2.554	0.01063	0.2789	0.3583	0.39667	0.3281	54	130	116	40	170	171
  rs17189710	Imputed	T	GEN	681					7.872	0.01953	0.2789	0.3583	0.39667	0.3281	54	130	116	40	170	171
  rs17196143	Imputed	A	ADD	682	1.57	0.1416	1.189	2.072	3.183	0.001458	0.6286	0.19721	0.23667	0.1662	12	118	170	12	103	267
  rs17353809	Imputed	G	ADD	674	1.511	0.1348	1.16	1.968	3.062	0.002199	0.9094	0.21588	0.25424	0.186	22	106	167	10	121	248
  rs17368986	Imputed	A	GEN	682					13.99	0.000919	0.07037	0.19721	0.24167	0.1623	26	93	181	8	108	266
  rs17369097	Imputed	A	GEN	681					13.12	0.001413	0.1414	0.19457	0.23833	0.1601	24	95	181	8	106	267
  rs17434511	Imputed	C	GEN	679					13.93	0.000944	0.06935	0.19735	0.24161	0.1627	26	92	180	8	108	265
  rs17434589	Imputed	C	GEN	673					14.2	0.000826	0.06943	0.19837	0.24407	0.1627	26	92	177	8	107	263
  rs17434603	Imputed	G	GEN	680					13.78	0.001017	0.06901	0.19706	0.2408	0.1627	26	92	181	8	108	265
  rs17434840	Imputed	C	GEN	681					13.12	0.001413	0.1414	0.19457	0.23833	0.1601	24	95	181	8	106	267
  rs17446418	Imputed	G	DOM	678	0.537	0.1603	0.3921	0.7351	−3.88	0.000105	0.8045	0.36873	0.31711	0.4092	35	119	144	59	193	128
  rs17530747	Imputed	T	DOM	669	0.525	0.1614	0.383	0.7209	−3.988	6.66E−05	0.8027	0.36398	0.30887	0.4069	32	117	144	58	190	128
  rs17604285	Imputed	C	ADD	681	0.533	0.1972	0.3619	0.7838	−3.195	0.001397	0.2868	0.09912	0.06833	0.1234	2	37	261	7	80	294
  rs17604285	Imputed	C	DOM	681	0.504	0.212	0.3327	0.7638	−3.231	0.001233	0.2868	0.09912	0.06833	0.1234	2	37	261	7	80	294
  rs17662322	Imputed	T	DOM	681	0.555	0.17	0.3978	0.7746	−3.463	0.000535	1	0.18135	0.13712	0.216	4	74	221	18	129	235
  rs17769826	Imputed	T	ADD	677	1.504	0.1347	1.155	1.958	3.029	0.002453	0.9092	0.21492	0.25253	0.1855	22	106	169	10	121	249
  rs17821641	Imputed	T	ADD	679	1.5	0.1343	1.153	1.952	3.019	0.00254	1	0.21944	0.25671	0.1903	21	111	166	11	123	247
  rs1782328	Imputed	A	ADD	647	0.613	0.1454	0.4609	0.8148	−3.369	0.000754	0.1051	0.19706	0.15194	0.2321	6	74	203	26	117	221
  rs1796337	Imputed	T	DOM	669	0.597	0.1833	0.4168	0.8548	−2.816	0.004863	0.5361	0.51121	0.48142	0.5349	77	131	88	102	195	76
  rs1798083	Imputed	C	DOM	674	0.601	0.179	0.4232	0.8536	−2.845	0.004447	0.8775	0.48813	0.46959	0.5026	74	130	92	85	210	83
  rs1798085	Imputed	T	DOM	668	0.578	0.1804	0.4058	0.823	−3.04	0.002368	0.9383	0.48952	0.46928	0.5053	74	127	92	85	209	81
  rs1798086	Imputed	T	DOM	668	0.553	0.1797	0.3886	0.786	−3.3	0.000968	1	0.48653	0.46246	0.5053	73	125	95	85	209	81
  rs1798089	Imputed	C	GEN	675					11.13	0.00383	0.42	0.39333	0.43098	0.3638	59	138	100	40	195	143
  rs1798089	Imputed	C	REC	675	2.101	0.2227	1.358	3.252	3.334	0.000855	0.42	0.39333	0.43098	0.3638	59	138	100	40	195	143
  rs1798090	Imputed	C	GEN	674					10.63	0.004921	0.3765	0.39614	0.43412	0.3664	59	139	98	41	195	142
  rs1798090	Imputed	C	REC	674	2.054	0.2214	1.331	3.17	3.251	0.001151	0.3765	0.39614	0.43412	0.3664	59	139	98	41	195	142
  rs1832222	Imputed	G	DOM	682	1.786	0.1574	1.312	2.431	3.685	0.000229	1	0.29545	0.335	0.2644	26	149	125	33	136	213
  rs1838104	Imputed	A	ADD	668	0.727	0.1159	0.5791	0.9121	−2.754	0.005895	0.3083	0.55539	0.51199	0.5891	71	157	64	128	187	61
  rs1838104	Imputed	A	GEN	668					7.983	0.01848	0.3083	0.55539	0.51199	0.5891	71	157	64	128	187	61
  rs1868616	Imputed	G	ADD	671	0.572	0.1501	0.426	0.7672	−3.725	0.000195	0.7063	0.19001	0.14576	0.2247	4	78	213	18	133	225
  rs1874313	Imputed	A	DOM	674	0.578	0.1655	0.4178	0.7993	−3.314	0.000921	0.9364	0.40504	0.36824	0.4339	46	126	124	65	198	115
  rs1884902	Imputed	C	REC	678	2.217	0.2224	1.434	3.428	3.579	0.000344	0.6303	0.39381	0.44649	0.3522	61	145	93	41	185	153
  rs1913201	Imputed	G	ADD	650	0.692	0.1185	0.5487	0.873	−3.106	0.001894	0.3832	0.44692	0.40175	0.4822	45	139	101	79	194	92
  rs1913201	Imputed	G	DOM	650	0.589	0.1754	0.4175	0.8303	−3.02	0.002528	0.3832	0.44692	0.40175	0.4822	45	139	101	79	194	92
  rs1913201	Imputed	G	GEN	650					10.22	0.006038	0.3832	0.44692	0.40175	0.4822	45	139	101	79	194	92
  rs1944279	Imputed	A	ADD	679	1.579	0.1261	1.233	2.022	3.624	0.00029	0.6914	0.26068	0.30936	0.2224	30	125	144	18	133	229
  rs198461	Imputed	C	DOM	676	0.625	0.1925	0.4287	0.9117	−2.44	0.01467	0.04501	0.52367	0.49495	0.5462	71	152	74	101	212	66
  rs1987179	Imputed	T	DOM	680	0.701	0.1613	0.5109	0.9616	−2.203	0.0276	0.06175	0.20735	0.18562	0.2244	10	91	198	11	149	221
  rs1990023	Imputed	T	DOM	682	0.548	0.1595	0.4011	0.7494	−3.769	0.000164	0.9329	0.34824	0.30667	0.3809	36	112	152	46	199	137
  rs2016194	Imputed	G	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.9329	0.34824	0.30833	0.3796	36	113	151	46	198	138
  rs2024789	Imputed	C	ADD	666	0.675	0.1123	0.542	0.8417	−3.495	0.000475	0.3902	0.4542	0.39828	0.4973	49	133	108	94	186	96
  rs2024789	Imputed	C	GEN	666					12.34	0.002095	0.3902	0.4542	0.39828	0.4973	49	133	108	94	186	96
  rs2024902	Imputed	A	ADD	678	2.07	0.2296	1.32	3.246	3.168	0.001535	0.2503	0.07375	0.09732	0.0553	3	52	243	3	36	341
  rs2024902	Imputed	A	DOM	678	2.266	0.2451	1.401	3.663	3.336	0.000849	0.2503	0.07375	0.09732	0.0553	3	52	243	3	36	341
  rs2025107	Imputed	A	ADD	682	2.008	0.2082	1.336	3.02	3.35	0.000808	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs2025107	Imputed	A	DOM	682	2.219	0.2217	1.437	3.427	3.596	0.000324	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs2025108	Imputed	T	ADD	682	2.008	0.2082	1.336	3.02	3.35	0.000808	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs2025108	Imputed	T	DOM	682	2.219	0.2217	1.437	3.427	3.596	0.000324	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs2062448	Imputed	T	ADD	674	0.545	0.1992	0.3687	0.805	−3.049	0.002299	0.2633	0.09644	0.06711	0.1197	2	36	260	7	76	293
  rs2062448	Imputed	T	DOM	674	0.517	0.215	0.339	0.7873	−3.072	0.002123	0.2633	0.09644	0.06711	0.1197	2	36	260	7	76	293
  rs2063591	Imputed	C	ADD	677	0.73	0.1136	0.5839	0.9113	−2.777	0.005479	0.8173	0.47858	0.43792	0.5106	61	139	98	92	203	84
  rs2063591	Imputed	C	DOM	677	0.56	0.1767	0.3958	0.7911	−3.287	0.001014	0.8173	0.47858	0.43792	0.5106	61	139	98	92	203	84
  rs2065604	Imputed	C	DOM	682	0.529	0.2074	0.352	0.7937	−3.074	0.00211	0.6748	0.10191	0.07333	0.1243	2	40	258	6	83	293
  rs2066238	Imputed	T	DOM	682	0.521	0.1725	0.3715	0.7305	−3.78	0.000157	0.4294	0.17595	0.13667	0.2068	10	62	228	14	130	238
  rs2068051	Imputed	G	ADD	424	0.612	0.1413	0.464	0.8076	−3.472	0.000517	0.1925	0.58726	0.52332	0.6407	55	92	46	98	100	33
  rs2068051	Imputed	G	GEN	424					12.06	0.002411	0.1925	0.58726	0.52332	0.6407	55	92	46	98	100	33
  rs2077702	Genotyped	G	GEN	682					9.004	0.01108	0.5971	0.31818	0.35	0.2932	44	122	134	28	168	186
  rs208757	Imputed	G	ADD	652	1.552	0.1511	1.154	2.087	2.91	0.003619	0.4981	0.17485	0.20833	0.1484	9	102	177	8	92	264
  rs208757	Imputed	G	DOM	652	1.649	0.1701	1.182	2.302	2.942	0.003266	0.4981	0.17485	0.20833	0.1484	9	102	177	8	92	264
  rs2095586	Imputed	A	DOM	682	1.786	0.1574	1.312	2.431	3.685	0.000229	1	0.29545	0.335	0.2644	26	149	125	33	136	213
  rs2108426	Imputed	C	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.9329	0.34824	0.30833	0.3796	36	113	151	46	198	138
  rs2110664	Imputed	A	DOM	643	1.503	0.1611	1.096	2.061	2.53	0.01141	0.8422	0.27138	0.30674	0.2438	24	125	133	22	132	207
  rs2132242	Imputed	A	DOM	680	0.585	0.1661	0.4222	0.8097	−3.231	0.001233	1	0.41544	0.37919	0.4437	48	130	120	69	201	112
  rs2151644	Imputed	T	DOM	679	0.527	0.2075	0.3509	0.7914	−3.088	0.002018	0.6758	0.10236	0.07358	0.125	2	40	257	6	83	291
  rs2157752	Genotyped	A	GEN	682					12.46	0.001973	0.676	0.35557	0.30667	0.394	24	136	140	65	171	146
  rs2158958	Imputed	A	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.9329	0.34824	0.30833	0.3796	36	113	151	46	198	138
  rs2158961	Imputed	G	DOM	680	0.564	0.1598	0.412	0.7707	−3.59	0.00033	0.9326	0.34706	0.30833	0.3776	36	113	151	45	197	138
  rs2164099	Imputed	G	ADD	681	1.561	0.1254	1.221	1.995	3.551	0.000384	0.6918	0.26211	0.31	0.2244	30	126	144	19	133	229
  rs2173254	Imputed	G	GEN	675					12.63	0.001808	0.08658	0.34074	0.29561	0.376	17	141	138	51	183	145
  rs2173254	Imputed	G	REC	675	0.382	0.2927	0.2154	0.6786	−3.285	0.001021	0.08658	0.34074	0.29561	0.376	17	141	138	51	183	145
  rs2188079	Imputed	C	ADD	682	1.482	0.1139	1.186	1.853	3.457	0.000547	0.8148	0.42962	0.48333	0.3874	71	148	81	53	190	139
  rs2188079	Imputed	C	GEN	682					12.81	0.001651	0.8148	0.42962	0.48333	0.3874	71	148	81	53	190	139
  rs2190304	Imputed	G	REC	682	0.439	0.2056	0.2933	0.6567	−4.005	6.20E−05	0.2503	0.47947	0.42667	0.5209	44	168	88	105	188	89
  rs2190597	Imputed	T	DOM	681	0.559	0.174	0.3978	0.7868	−3.338	0.000844	0.9387	0.46916	0.43167	0.4987	63	133	104	86	208	87
  rs2190598	Imputed	T	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.9329	0.34824	0.30833	0.3796	36	113	151	46	198	138
  rs2190600	Imputed	A	DOM	672	0.561	0.1605	0.4097	0.7686	−3.6	0.000319	0.9321	0.34598	0.3064	0.3773	36	110	151	45	193	137
  rs2218084	Imputed	T	GEN	664					8.488	0.01435	0.02385	0.16416	0.18983	0.1436	19	74	202	7	92	270
  rs2218084	Imputed	T	REC	664	3.657	0.4516	1.509	8.862	2.871	0.004092	0.02385	0.16416	0.18983	0.1436	19	74	202	7	92	270
  rs2236290	Genotyped	C	GEN	680					6.499	0.0388	0.5618	0.36103	0.32667	0.3882	30	136	134	62	171	147
  rs2243860	Imputed	A	GEN	548					9.796	0.00746	0.1582	0.40785	0.45021	0.3746	50	117	74	33	164	110
  rs2243860	Imputed	A	REC	548	2.168	0.2486	1.332	3.529	3.113	0.00185	0.1582	0.40785	0.45021	0.3746	50	117	74	33	164	110
  rs2246564	Imputed	T	DOM	682	0.529	0.2074	0.352	0.7937	−3.074	0.00211	0.6748	0.10191	0.07333	0.1243	2	40	258	6	83	293
  rs2248236	Imputed	C	DOM	681	0.718	0.1608	0.524	0.9842	−2.059	0.03947	0.04865	0.20852	0.18833	0.2244	10	93	197	11	149	221
  rs2250340	Imputed	T	DOM	600	0.514	0.2136	0.3382	0.7813	−3.115	0.001837	0.8378	0.1125	0.08113	0.1373	2	39	224	6	80	249
  rs2257192	Imputed	G	DOM	682	0.529	0.2074	0.352	0.7937	−3.074	0.00211	0.6748	0.10191	0.07333	0.1243	2	40	258	6	83	293
  rs2270584	Imputed	A	DOM	679	0.567	0.1632	0.4117	0.7806	−3.477	0.000507	0.7495	0.40059	0.36622	0.4276	49	121	129	62	201	117
  rs2270586	Imputed	A	DOM	680	0.564	0.1631	0.4095	0.7761	−3.514	0.000442	0.8731	0.4	0.36622	0.4265	49	121	129	61	203	117
  rs2270589	Imputed	A	ADD	682	0.711	0.1121	0.5703	0.8851	−3.048	0.002301	0.877	0.44648	0.40167	0.4817	54	133	113	83	202	97
  rs2270589	Imputed	A	DOM	682	0.552	0.1689	0.3961	0.7679	−3.523	0.000426	0.877	0.44648	0.40167	0.4817	54	133	113	83	202	97
  rs2270589	Imputed	A	GEN	682					12.43	0.001996	0.877	0.44648	0.40167	0.4817	54	133	113	83	202	97
  rs2296889	Imputed	C	DOM	672	1.638	0.1743	1.164	2.305	2.832	0.004632	0.7651	0.15253	0.17508	0.1347	3	98	196	11	79	285
  rs2301346	Imputed	C	ADD	550	1.573	0.133	1.212	2.042	3.407	0.000656	0.2216	0.29818	0.35124	0.2565	32	106	104	23	112	173
  rs2301346	Imputed	C	DOM	550	1.763	0.1765	1.248	2.492	3.214	0.001311	0.2216	0.29818	0.35124	0.2565	32	106	104	23	112	173
  rs2327929	Imputed	G	REC	682	2.122	0.1996	1.435	3.137	3.769	0.000164	0.09898	0.42155	0.47333	0.3809	77	130	93	55	181	146
  rs2357486	Imputed	C	REC	673	2.717	0.2622	1.625	4.542	3.812	0.000138	0.7297	0.33432	0.37752	0.3	48	129	121	25	175	175
  rs2373793	Imputed	G	DOM	646	1.534	0.1778	1.083	2.173	2.407	0.0161	0.1726	0.15402	0.18151	0.1314	11	84	197	9	75	270
  rs2377622	Imputed	T	GEN	552					7.759	0.02066	0.9252	0.34692	0.3125	0.3719	18	109	105	49	140	131
  rs2377622	Imputed	T	REC	552	0.437	0.2982	0.2436	0.784	−2.776	0.005501	0.9252	0.34692	0.3125	0.3719	18	109	105	49	140	131
  rs2383903	Imputed	G	DOM	681	0.614	0.1576	0.4507	0.836	−3.096	0.001959	0.9247	0.28267	0.245	0.3123	22	103	175	33	172	176
  rs2389866	Imputed	C	DOM	681	0.697	0.1612	0.508	0.9558	−2.24	0.02509	0.06186	0.20705	0.185	0.2244	10	91	199	11	149	221
  rs2389869	Imputed	C	DOM	681	0.697	0.1612	0.508	0.9558	−2.24	0.02509	0.06186	0.20705	0.185	0.2244	10	91	199	11	149	221
  rs2418541	Imputed	A	DOM	681	0.551	0.1595	0.4029	0.753	−3.738	0.000186	1	0.34802	0.30667	0.3806	36	112	152	46	198	137
  rs2418542	Imputed	A	DOM	681	0.551	0.1595	0.4029	0.753	−3.738	0.000186	1	0.34802	0.30667	0.3806	36	112	152	46	198	137
  rs2418548	Imputed	C	DOM	630	0.572	0.1639	0.4145	0.788	−3.414	0.00064	0.9279	0.32698	0.29474	0.3536	33	102	150	35	174	136
  rs2476976	Imputed	C	DOM	681	1.728	0.1579	1.268	2.355	3.465	0.00053	0.855	0.29736	0.33278	0.2696	25	149	125	34	138	210
  rs2483639	Imputed	A	DOM	682	0.529	0.2074	0.352	0.7937	−3.074	0.00211	0.6748	0.10191	0.07333	0.1243	2	40	258	6	83	293
  rs2483640	Imputed	A	DOM	682	0.529	0.2074	0.352	0.7937	−3.074	0.00211	0.6748	0.10191	0.07333	0.1243	2	40	258	6	83	293
  rs2544780	Imputed	T	REC	670	1.881	0.2505	1.151	3.073	2.521	0.0117	0.248	0.3194	0.35959	0.2884	43	124	125	32	154	192
  rs2586458	Imputed	T	DOM	322	0.507	0.2771	0.2947	0.8733	−2.449	0.01433	0.4953	0.14286	0.10465	0.1684	3	21	105	5	55	133
  rs2593272	Imputed	G	ADD	682	0.712	0.1296	0.5521	0.9177	−2.623	0.00872	0.6186	0.25953	0.225	0.2866	12	111	177	31	157	194
  rs2593273	Imputed	T	ADD	678	0.699	0.1321	0.5396	0.9057	−2.71	0.006738	0.3627	0.25516	0.2198	0.2829	10	111	177	29	157	194
  rs2622499	Imputed	G	DOM	682	0.726	0.1604	0.5299	0.9939	−1.998	0.04572	0.08586	0.21261	0.19333	0.2277	11	94	195	12	150	220
  rs264126	Imputed	C	DOM	679	0.553	0.1744	0.3932	0.779	−3.392	0.000693	0.9386	0.46981	0.43167	0.5	63	133	104	86	207	86
  rs264129	Imputed	T	DOM	681	0.561	0.1597	0.4104	0.7675	−3.617	0.000298	1	0.34802	0.30833	0.3793	36	113	151	46	197	138
  rs2656822	Imputed	T	ADD	682	0.712	0.1296	0.5521	0.9177	−2.623	0.00872	0.6186	0.25953	0.225	0.2866	12	111	177	31	157	194
  rs2656823	Imputed	G	ADD	682	0.712	0.1296	0.5521	0.9177	−2.623	0.00872	0.6186	0.25953	0.225	0.2866	12	111	177	31	157	194
  rs2656825	Imputed	T	ADD	665	0.702	0.1338	0.5398	0.9119	−2.649	0.00807	0.4115	0.25263	0.21747	0.2802	9	109	174	29	151	193
  rs2764766	Imputed	C	REC	678	1.803	0.2463	1.112	2.922	2.393	0.01673	0.2549	0.32448	0.36364	0.294	44	128	125	34	156	191
  rs2793101	Imputed	T	ADD	680	0.506	0.1889	0.3491	0.732	−3.612	0.000304	1	0.1125	0.07833	0.1395	1	45	254	7	92	281
  rs2793101	Imputed	T	DOM	680	0.501	0.2	0.3385	0.7413	−3.457	0.000547	1	0.1125	0.07833	0.1395	1	45	254	7	92	281
  rs2795871	Imputed	A	ADD	676	0.578	0.2256	0.3717	0.9	−2.427	0.01522	0.3783	0.07175	0.05201	0.0873	0	31	267	5	56	317
  rs2795886	Imputed	A	ADD	681	0.507	0.2747	0.2962	0.8693	−2.47	0.01352	0.0724	0.04919	0.03167	0.063	0	19	281	4	40	337
  rs2795886	Imputed	A	DOM	681	0.517	0.2884	0.2939	0.9104	−2.285	0.02229	0.0724	0.04919	0.03167	0.063	0	19	281	4	40	337
  rs2859994	Imputed	C	GEN	645					9.449	0.008877	0.112	0.37984	0.41986	0.3478	49	143	95	34	181	143
  rs2870464	Imputed	G	DOM	682	1.534	0.1771	1.084	2.171	2.417	0.01564	0.5379	0.14443	0.17	0.1243	9	84	207	7	81	294
  rs2875528	Imputed	T	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs2876227	Imputed	C	ADD	640	1.393	0.1179	1.106	1.755	2.811	0.00494	0.226	0.35156	0.39785	0.3158	50	122	107	36	156	169
  rs2876227	Imputed	C	GEN	640					8.788	0.01235	0.226	0.35156	0.39785	0.3158	50	122	107	36	156	169
  rs2882097	Imputed	A	DOM	682	1.772	0.1576	1.301	2.413	3.63	0.000284	1	0.29692	0.335	0.267	26	149	125	34	136	212
  rs2921983	Imputed	C	ADD	640	0.679	0.1387	0.5173	0.8909	−2.793	0.00522	0.5889	0.23984	0.20285	0.2688	9	96	176	25	143	191
  rs2987537	Imputed	C	DOM	682	0.501	0.1957	0.3413	0.735	−3.533	0.000411	0.2158	0.1239	0.09	0.1505	5	44	251	9	97	276
  rs2996416	Imputed	C	ADD	682	0.518	0.1922	0.3551	0.7544	−3.426	0.000612	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs2996416	Imputed	C	DOM	682	0.474	0.2097	0.3145	0.7155	−3.556	0.000376	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs3015527	Imputed	C	ADD	677	0.519	0.1922	0.3558	0.7559	−3.416	0.000635	0.303	0.10487	0.07191	0.131	3	37	259	7	85	286
  rs3015527	Imputed	C	DOM	677	0.476	0.2098	0.3154	0.7179	−3.54	0.000401	0.303	0.10487	0.07191	0.131	3	37	259	7	85	286
  rs3015530	Imputed	C	ADD	682	0.518	0.1922	0.3551	0.7544	−3.426	0.000612	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs3015530	Imputed	C	DOM	682	0.474	0.2097	0.3145	0.7155	−3.556	0.000376	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs3015531	Imputed	T	ADD	682	0.518	0.1922	0.3551	0.7544	−3.426	0.000612	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs3015531	Imputed	T	DOM	682	0.474	0.2097	0.3145	0.7155	−3.556	0.000376	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs3015535	Imputed	C	ADD	682	0.518	0.1922	0.3551	0.7544	−3.426	0.000612	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs3015535	Imputed	C	DOM	682	0.474	0.2097	0.3145	0.7155	−3.556	0.000376	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs3019407	Imputed	A	GEN	675					12.63	0.001808	0.08658	0.34074	0.29561	0.376	17	141	138	51	183	145
  rs3019407	Imputed	A	REC	675	0.382	0.2927	0.2154	0.6786	−3.285	0.001021	0.08658	0.34074	0.29561	0.376	17	141	138	51	183	145
  rs36071725	Genotyped	C	GEN	682					15.36	0.000463	0.6072	0.33724	0.38333	0.301	49	132	119	25	180	177
  rs373983	Imputed	G	DOM	661	1.911	0.1684	1.373	2.658	3.844	0.000121	0.4632	0.39334	0.44692	0.3509	55	151	86	52	155	162
  rs3756154	Imputed	C	DOM	681	0.697	0.1612	0.508	0.9558	−2.24	0.02509	0.06186	0.20705	0.185	0.2244	10	91	199	11	149	221
  rs3793044	Imputed	C	ADD	682	2.264	0.2373	1.422	3.606	3.444	0.000573	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs3793044	Imputed	C	DOM	682	2.432	0.2521	1.484	3.986	3.525	0.000423	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs3793053	Imputed	C	ADD	672	2.017	0.2117	1.332	3.055	3.316	0.000914	0.6256	0.08705	0.11409	0.0655	3	62	233	3	43	328
  rs3793053	Imputed	C	DOM	672	2.188	0.2249	1.408	3.4	3.48	0.000501	0.6256	0.08705	0.11409	0.0655	3	62	233	3	43	328
  rs3796246	Imputed	G	ADD	682	0.511	0.2045	0.3419	0.7623	−3.287	0.001012	1	0.09531	0.065	0.1191	1	37	262	5	81	296
  rs3796246	Imputed	G	DOM	682	0.497	0.2139	0.3265	0.7551	−3.273	0.001063	1	0.09531	0.065	0.1191	1	37	262	5	81	296
  rs3805996	Imputed	G	ADD	662	2.146	0.2358	1.352	3.407	3.239	0.001199	0.1442	0.07251	0.0976	0.0527	3	51	238	3	33	334
  rs3805996	Imputed	G	DOM	662	2.368	0.2509	1.448	3.871	3.436	0.00059	0.1442	0.07251	0.0976	0.0527	3	51	238	3	33	334
  rs3806003	Imputed	A	ADD	682	2.264	0.2373	1.422	3.606	3.444	0.000573	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs3806003	Imputed	A	DOM	682	2.432	0.2521	1.484	3.986	3.525	0.000423	0.205	0.06598	0.09167	0.0458	3	49	248	2	31	349
  rs3806004	Imputed	T	ADD	682	2.008	0.2082	1.336	3.02	3.35	0.000808	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806004	Imputed	T	DOM	682	2.219	0.2217	1.437	3.427	3.596	0.000324	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806010	Imputed	T	ADD	682	2.008	0.2082	1.336	3.02	3.35	0.000808	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806010	Imputed	T	DOM	682	2.219	0.2217	1.437	3.427	3.596	0.000324	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806014	Imputed	T	ADD	682	2.008	0.2082	1.336	3.02	3.35	0.000808	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806014	Imputed	T	DOM	682	2.219	0.2217	1.437	3.427	3.596	0.000324	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806015	Imputed	A	ADD	682	2.008	0.2082	1.336	3.02	3.35	0.000808	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806015	Imputed	A	DOM	682	2.219	0.2217	1.437	3.427	3.596	0.000324	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806018	Imputed	A	ADD	682	2.008	0.2082	1.336	3.02	3.35	0.000808	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806018	Imputed	A	DOM	682	2.219	0.2217	1.437	3.427	3.596	0.000324	0.4997	0.09238	0.12	0.0707	3	66	231	4	46	332
  rs3806019	Imputed	A	ADD	678	2.145	0.2126	1.414	3.253	3.588	0.000333	0.6198	0.08555	0.11538	0.062	3	63	233	3	41	335
  rs3806019	Imputed	A	DOM	678	2.353	0.2258	1.511	3.663	3.788	0.000152	0.6198	0.08555	0.11538	0.062	3	63	233	3	41	335
  rs3806024	Imputed	T	ADD	672	2.017	0.2117	1.332	3.055	3.316	0.000914	0.6256	0.08705	0.11409	0.0655	3	62	233	3	43	328
  rs3806024	Imputed	T	DOM	672	2.188	0.2249	1.408	3.4	3.48	0.000501	0.6256	0.08705	0.11409	0.0655	3	62	233	3	43	328
  rs3847825	Imputed	G	ADD	680	0.691	0.112	0.5544	0.8601	−3.305	0.00095	0.03311	0.37353	0.32107	0.4147	33	126	140	75	166	140
  rs3847825	Imputed	G	GEN	680					11.36	0.003414	0.03311	0.37353	0.32107	0.4147	33	126	140	75	166	140
  rs3852001	Genotyped	C	GEN	682					13.99	0.000919	0.07037	0.19721	0.24167	0.1623	26	93	181	8	108	266
  rs3852001	Genotyped	C	REC	682	4.254	0.4136	1.891	9.569	3.5	0.000465	0.07037	0.19721	0.24167	0.1623	26	93	181	8	108	266
  rs3852002	Imputed	G	GEN	681					13.41	0.001226	0.08816	0.1953	0.23913	0.161	25	93	181	8	107	267
  rs3852002	Imputed	G	REC	681	4.089	0.4152	1.812	9.226	3.392	0.000694	0.08816	0.1953	0.23913	0.161	25	93	181	8	107	267
  rs3852003	Imputed	A	GEN	681					13.41	0.001226	0.08816	0.1953	0.23913	0.161	25	93	181	8	107	267
  rs3852003	Imputed	A	REC	681	4.089	0.4152	1.812	9.226	3.392	0.000694	0.08816	0.1953	0.23913	0.161	25	93	181	8	107	267
  rs3942254	Imputed	T	DOM	678	0.6	0.1651	0.4341	0.8292	−3.094	0.001974	1	0.40413	0.37037	0.4304	46	128	123	65	198	118
  rs3945085	Imputed	A	DOM	682	1.794	0.1572	1.319	2.442	3.72	0.000199	1	0.29252	0.33167	0.2618	25	149	126	33	134	215
  rs399485	Imputed	A	DOM	678	1.537	0.1571	1.129	2.091	2.735	0.006241	0.697	0.26917	0.30705	0.2395	27	129	142	24	134	222
  rs4029119	Imputed	G	ADD	682	0.217	0.4129	0.0965	0.4867	−3.704	0.000213	0.06816	0.03812	0.01667	0.055	0	10	290	3	36	343
  rs4029119	Imputed	G	DOM	682	0.223	0.4255	0.0967	0.5123	−3.532	0.000412	0.06816	0.03812	0.01667	0.055	0	10	290	3	36	343
  rs412791	Imputed	C	GEN	675					12.74	0.001714	0.8702	0.38	0.33054	0.4191	27	143	128	69	178	130
  rs4146972	Genotyped	T	DOM	682	1.42	0.1657	1.026	1.965	2.117	0.0343	0.6059	0.18035	0.19833	0.1662	8	103	189	16	95	271
  rs4259369	Imputed	C	REC	679	0.645	0.1981	0.4374	0.9509	−2.214	0.02681	0.01503	0.42636	0.40468	0.4434	50	142	107	89	159	132
  rs4273613	Imputed	T	ADD	682	0.217	0.4129	0.0965	0.4867	−3.704	0.000213	0.06816	0.03812	0.01667	0.055	0	10	290	3	36	343
  rs4273613	Imputed	T	DOM	682	0.223	0.4255	0.0967	0.5123	−3.532	0.000412	0.06816	0.03812	0.01667	0.055	0	10	290	3	36	343
  rs4294022	Imputed	C	DOM	659	0.632	0.1627	0.4591	0.8687	−2.825	0.004728	1	0.23293	0.19792	0.2601	13	88	187	23	147	201
  rs4310554	Genotyped	C	DOM	682	1.747	0.1888	1.207	2.53	2.956	0.00312	0.2203	0.49707	0.54167	0.462	81	163	56	79	195	108
  rs4315598	Imputed	T	ADD	682	1.338	0.1141	1.07	1.674	2.555	0.01063	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs4315598	Imputed	T	GEN	682					7.867	0.01957	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs4370878	Imputed	G	DOM	682	1.755	0.157	1.29	2.388	3.583	0.00034	0.9265	0.29399	0.33167	0.2644	25	149	126	33	136	213
  rs4436200	Imputed	C	ADD	682	0.718	0.169	0.5154	0.9996	−1.963	0.0497	0.2391	0.1305	0.11	0.1466	5	56	239	10	92	280
  rs4444612	Imputed	G	ADD	682	1.338	0.1141	1.07	1.674	2.555	0.01063	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs4444612	Imputed	G	GEN	682					7.867	0.01957	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs4450660	Imputed	C	DOM	675	1.654	0.1588	1.212	2.258	3.168	0.001533	0.07497	0.24296	0.27778	0.2156	15	135	147	16	131	231
  rs4463950	Imputed	C	DOM	671	0.617	0.1688	0.4431	0.8588	−2.862	0.004214	0.9374	0.43294	0.40541	0.4547	56	128	112	69	203	103
  rs4509702	Imputed	C	DOM	682	1.755	0.157	1.29	2.388	3.583	0.00034	0.9265	0.29399	0.33167	0.2644	25	149	126	33	136	213
  rs4533379	Imputed	G	ADD	681	1.561	0.1254	1.221	1.995	3.551	0.000384	0.6918	0.26211	0.31	0.2244	30	126	144	19	133	229
  rs4569984	Imputed	A	DOM	671	0.645	0.1612	0.4706	0.8853	−2.715	0.006623	0.8278	0.231	0.19661	0.258	13	90	192	24	146	206
  rs4570530	Imputed	C	DOM	681	1.766	0.1571	1.298	2.403	3.62	0.000295	0.9266	0.29369	0.33167	0.2638	25	149	126	33	135	213
  rs4571583	Imputed	T	DOM	666	0.645	0.162	0.4697	0.8862	−2.706	0.006814	0.9134	0.23123	0.19759	0.2573	13	89	189	23	147	205
  rs4586678	Imputed	A	DOM	678	1.637	0.1582	1.2	2.232	3.114	0.001843	0.07807	0.24484	0.27852	0.2184	15	136	147	17	132	231
  rs4615971	Imputed	C	DOM	676	1.8	0.1582	1.32	2.455	3.716	0.000202	0.9269	0.29734	0.33784	0.2658	26	148	122	33	136	211
  rs4629229	Imputed	G	DOM	682	0.521	0.1725	0.3715	0.7305	−3.78	0.000157	0.4294	0.17595	0.13667	0.2068	10	62	228	14	130	238
  rs4632512	Imputed	T	GEN	681					13.12	0.001413	0.1414	0.19457	0.23833	0.1601	24	95	181	8	106	267
  rs4641552	Imputed	A	ADD	678	0.514	0.2311	0.3271	0.8092	−2.876	0.004025	0.7689	0.07153	0.04849	0.0897	0	29	270	4	60	315
  rs4682527	Imputed	C	DOM	656	1.64	0.1669	1.183	2.275	2.966	0.003017	0.3618	0.37805	0.40941	0.3537	39	157	91	49	163	157
  rs4688632	Imputed	G	REC	675	0.538	0.1943	0.3678	0.7876	−3.189	0.001429	0.3557	0.48889	0.45424	0.5158	50	168	77	105	182	93
  rs4702720	Imputed	A	ADD	530	0.596	0.1535	0.4412	0.8051	−3.372	0.000745	0.08183	0.22547	0.17842	0.2647	11	64	166	23	107	159
  rs4702720	Imputed	A	DOM	530	0.541	0.1863	0.3758	0.7798	−3.295	0.000984	0.08183	0.22547	0.17842	0.2647	11	64	166	23	107	159
  rs4714484	Imputed	A	ADD	681	0.631	0.1545	0.4661	0.8539	−2.982	0.002861	0.8896	0.1652	0.13	0.1929	5	68	227	14	119	248
  rs4714484	Imputed	A	DOM	681	0.606	0.1733	0.4315	0.8511	−2.89	0.003849	0.8896	0.1652	0.13	0.1929	5	68	227	14	119	248
  rs4725142	Genotyped	G	REC	682	0.444	0.2656	0.2639	0.7476	−3.055	0.002251	0.2804	0.3585	0.33667	0.3757	23	156	121	58	171	153
  rs4725144	Imputed	G	REC	677	0.427	0.2722	0.2502	0.7275	−3.129	0.001756	0.2734	0.35229	0.32886	0.3707	21	154	123	56	169	154
  rs4760785	Imputed	A	ADD	657	0.709	0.1165	0.5639	0.8903	−2.957	0.003102	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs4760785	Imputed	A	DOM	657	0.595	0.1749	0.4222	0.8382	−2.969	0.002989	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs4760894	Imputed	T	ADD	657	0.709	0.1165	0.5639	0.8903	−2.957	0.003102	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs4760894	Imputed	T	DOM	657	0.595	0.1749	0.4222	0.8382	−2.969	0.002989	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs4760895	Imputed	A	ADD	657	0.709	0.1165	0.5639	0.8903	−2.957	0.003102	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs4760895	Imputed	A	DOM	657	0.595	0.1749	0.4222	0.8382	−2.969	0.002989	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs4767184	Imputed	C	ADD	678	0.704	0.1112	0.5659	0.8752	−3.159	0.001584	0.02822	0.38127	0.3311	0.4208	37	124	138	75	169	135
  rs4767184	Imputed	C	GEN	678					9.99	0.006772	0.02822	0.38127	0.3311	0.4208	37	124	138	75	169	135
  rs4773487	Imputed	T	ADD	682	0.555	0.1837	0.3871	0.7953	−3.207	0.001342	0.2503	0.11364	0.08167	0.1387	3	43	254	9	88	285
  rs4780547	Imputed	G	GEN	682					8.214	0.01646	0.1488	0.22141	0.19167	0.2448	9	97	194	31	125	226
  rs4780547	Imputed	G	REC	682	0.327	0.3979	0.1501	0.7141	−2.806	0.005013	0.1488	0.22141	0.19167	0.2448	9	97	194	31	125	226
  rs483159	Imputed	T	DOM	611	1.742	0.1718	1.244	2.44	3.23	0.001236	0.899	0.19722	0.23432	0.1676	11	105	155	12	90	238
  rs4836502	Imputed	T	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.9329	0.34824	0.30833	0.3796	36	113	151	46	198	138
  rs4836507	Imputed	C	DOM	672	0.561	0.1605	0.4097	0.7686	−3.6	0.000319	0.9321	0.34598	0.3064	0.3773	36	110	151	45	193	137
  rs4851531	Imputed	T	DOM	677	0.722	0.1629	0.5246	0.9935	−2	0.0455	1	0.4062	0.37584	0.4301	44	136	118	68	190	121
  rs4879931	Imputed	G	ADD	678	0.672	0.1211	0.5303	0.8526	−3.277	0.00105	0.2044	0.30457	0.25758	0.3412	22	109	166	48	164	169
  rs489441	Imputed	G	ADD	631	1.549	0.1342	1.191	2.015	3.261	0.00111	0.4702	0.2607	0.30545	0.2261	20	128	127	19	123	214
  rs489441	Imputed	G	DOM	631	1.778	0.164	1.289	2.452	3.509	0.00045	0.4702	0.2607	0.30545	0.2261	20	128	127	19	123	214
  rs4976276	Imputed	T	ADD	681	1.45	0.125	1.135	1.853	2.973	0.002945	0.07074	0.3047	0.345	0.273	32	143	125	21	166	194
  rs4977681	Imputed	C	REC	682	2.487	0.278	1.442	4.288	3.278	0.001047	0.7153	0.29912	0.33	0.2749	41	116	143	22	166	194
  rs4986197	Imputed	G	ADD	679	1.564	0.1255	1.223	2	3.563	0.000366	0.6211	0.26215	0.3104	0.2244	30	125	143	19	133	229
  rs4986220	Imputed	T	ADD	681	1.538	0.1266	1.2	1.971	3.4	0.000673	0.8411	0.25698	0.30268	0.2212	28	125	146	18	133	231
  rs525462	Imputed	A	GEN	682					4.513	0.1047	0.1205	0.56012	0.53	0.5838	88	142	70	136	174	72
  rs552006	Imputed	G	GEN	678					9.189	0.01011	0.00901	0.2913	0.32886	0.2618	44	108	146	28	143	209
  rs5756669	Imputed	C	DOM	679	1.798	0.1769	1.271	2.543	3.316	0.000914	1	0.45582	0.49664	0.4239	66	164	68	75	173	133
  rs581905	Imputed	T	DOM	681	1.742	0.218	1.137	2.671	2.548	0.01085	1	0.08003	0.10167	0.063	3	55	242	1	46	334
  rs6033138	Imputed	C	ADD	682	1.338	0.1141	1.07	1.674	2.555	0.01063	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs6033138	Imputed	C	GEN	682					7.867	0.01957	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs6040619	Imputed	C	ADD	677	1.341	0.1132	1.074	1.675	2.594	0.009478	0.2114	0.36115	0.40101	0.3298	55	129	114	41	168	170
  rs6040619	Imputed	C	GEN	677					7.963	0.01866	0.2114	0.36115	0.40101	0.3298	55	129	114	41	168	170
  rs6040625	Imputed	T	ADD	680	1.351	0.1131	1.082	1.686	2.66	0.007824	0.2138	0.36103	0.40167	0.3289	55	131	114	41	168	171
  rs6040625	Imputed	T	GEN	680					8.078	0.01761	0.2138	0.36103	0.40167	0.3289	55	131	114	41	168	171
  rs6040630	Imputed	A	ADD	679	1.356	0.1137	1.085	1.694	2.676	0.007453	0.317	0.35935	0.4	0.3272	54	132	114	40	168	171
  rs6040630	Imputed	A	GEN	679					8.108	0.01735	0.317	0.35935	0.4	0.3272	54	132	114	40	168	171
  rs6040633	Imputed	A	ADD	679	1.356	0.1137	1.085	1.694	2.676	0.007453	0.317	0.35935	0.4	0.3272	54	132	114	40	168	171
  rs6040633	Imputed	A	GEN	679					8.108	0.01735	0.317	0.35935	0.4	0.3272	54	132	114	40	168	171
  rs6040634	Imputed	T	ADD	682	1.306	0.1123	1.048	1.628	2.378	0.01743	0.2463	0.3629	0.4	0.3338	54	132	114	43	169	170
  rs6040634	Imputed	T	GEN	682					6.36	0.0416	0.2463	0.3629	0.4	0.3338	54	132	114	43	169	170
  rs6040636	Imputed	T	ADD	681	1.312	0.1124	1.052	1.635	2.413	0.01583	0.2147	0.3627	0.4	0.3333	54	132	114	43	168	170
  rs6040636	Imputed	T	GEN	681					6.462	0.03952	0.2147	0.3627	0.4	0.3333	54	132	114	43	168	170
  rs6040638	Imputed	C	ADD	682	1.338	0.1141	1.07	1.674	2.555	0.01063	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs6040638	Imputed	C	GEN	682					7.867	0.01957	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs6040644	Imputed	A	ADD	680	1.338	0.1141	1.07	1.674	2.554	0.01065	0.2795	0.35882	0.39799	0.3281	54	130	115	40	170	171
  rs6040644	Imputed	A	GEN	680					7.863	0.01962	0.2795	0.35882	0.39799	0.3281	54	130	115	40	170	171
  rs6040667	Imputed	T	ADD	669	1.394	0.1165	1.11	1.752	2.853	0.004333	0.3047	0.34529	0.38908	0.3112	50	128	115	36	162	178
  rs6040667	Imputed	T	GEN	669					8.924	0.01154	0.3047	0.34529	0.38908	0.3112	50	128	115	36	162	178
  rs6040668	Imputed	C	ADD	669	1.394	0.1165	1.11	1.752	2.853	0.004333	0.3047	0.34529	0.38908	0.3112	50	128	115	36	162	178
  rs6040668	Imputed	C	GEN	669					8.924	0.01154	0.3047	0.34529	0.38908	0.3112	50	128	115	36	162	178
  rs6053005	Imputed	C	DOM	479	0.644	0.2558	0.3901	1.063	−1.72	0.08545	0.7029	0.60334	0.59709	0.6081	78	90	38	94	144	35
  rs6054405	Imputed	A	REC	679	2.249	0.2226	1.454	3.478	3.641	0.000271	0.6876	0.39323	0.44631	0.3517	61	144	93	41	186	154
  rs6054427	Genotyped	G	GEN	682					12.27	0.002167	0.4728	0.39736	0.44667	0.3586	59	150	91	44	186	152
  rs6075186	Imputed	G	DOM	682	0.521	0.1725	0.3715	0.7305	−3.78	0.000157	0.4294	0.17595	0.13667	0.2068	10	62	228	14	130	238
  rs608278	Imputed	A	ADD	594	0.702	0.1219	0.5527	0.8913	−2.904	0.003681	0.8663	0.41835	0.37354	0.4525	39	114	104	66	173	98
  rs6111540	Imputed	A	ADD	630	0.643	0.1186	0.5094	0.8109	−3.727	0.000194	0.8731	0.47619	0.41455	0.5239	45	138	92	99	174	82
  rs6131206	Imputed	C	ADD	668	1.277	0.1203	1.009	1.617	2.033	0.04201	0.3108	0.29865	0.3299	0.2745	36	120	135	29	149	199
  rs6131208	Imputed	T	ADD	669	1.394	0.1165	1.11	1.752	2.853	0.004333	0.3047	0.34529	0.38908	0.3112	50	128	115	36	162	178
  rs6131208	Imputed	T	GEN	669					8.924	0.01154	0.3047	0.34529	0.38908	0.3112	50	128	115	36	162	178
  rs6131919	Imputed	G	DOM	682	0.521	0.1725	0.3715	0.7305	−3.78	0.000157	0.4294	0.17595	0.13667	0.2068	10	62	228	14	130	238
  rs6134243	Imputed	C	ADD	682	1.338	0.1141	1.07	1.674	2.555	0.01063	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs6134243	Imputed	C	GEN	682					7.867	0.01957	0.2786	0.35777	0.39667	0.3272	54	130	116	40	170	172
  rs6136020	Imputed	A	DOM	681	0.511	0.1731	0.3638	0.7171	−3.881	0.000104	0.4267	0.17548	0.13545	0.2068	10	61	228	14	130	238
  rs613799	Imputed	C	DOM	582	1.79	0.1709	1.28	2.502	3.405	0.000663	1	0.28866	0.32738	0.2591	20	125	107	28	115	187
  rs644041	Imputed	G	ADD	621	1.565	0.135	1.201	2.039	3.319	0.000902	0.4688	0.26329	0.30882	0.2278	21	126	125	18	123	208
  rs644041	Imputed	G	DOM	621	1.762	0.165	1.275	2.435	3.433	0.000597	0.4688	0.26329	0.30882	0.2278	21	126	125	18	123	208
  rs6464377	Imputed	C	DOM	681	2.223	0.2258	1.428	3.46	3.538	0.000404	0.5678	0.07269	0.09833	0.0525	0	59	241	2	36	343
  rs6474230	Imputed	T	DOM	681	1.542	0.1596	1.127	2.108	2.712	0.006696	0.106	0.23128	0.25585	0.212	17	119	163	27	108	247
  rs6476565	Imputed	A	DOM	677	0.524	0.2092	0.3479	0.7901	−3.086	0.00203	0.6704	0.10118	0.07239	0.1237	2	39	256	6	82	292
  rs6511286	Imputed	T	ADD	675	1.359	0.1178	1.079	1.712	2.603	0.009243	0.5353	0.31852	0.3557	0.2891	37	138	123	35	148	194
  rs6541829	Genotyped	C	REC	682	1.978	0.3119	1.073	3.646	2.187	0.02875	0.9213	0.2632	0.28833	0.2435	28	117	155	20	146	216
  rs6544721	Imputed	G	DOM	675	1.623	0.1588	1.189	2.216	3.049	0.002295	0.05817	0.24148	0.27458	0.2158	14	134	147	16	132	232
  rs6544728	Imputed	T	DOM	680	1.638	0.158	1.202	2.233	3.124	0.001785	0.03564	0.23971	0.27592	0.2113	15	135	149	14	133	234
  rs6565910	Imputed	G	DOM	675	0.576	0.1625	0.4188	0.7919	−3.395	0.000685	0.1512	0.24963	0.21044	0.2804	19	87	191	30	152	196
  rs6581985	Imputed	G	GEN	661					8.243	0.01622	0.7098	0.29728	0.32646	0.2743	35	120	136	21	161	188
  rs6581985	Imputed	G	REC	661	2.29	0.2899	1.298	4.042	2.859	0.004255	0.7098	0.29728	0.32646	0.2743	35	120	136	21	161	188
  rs6685186	Imputed	T	ADD	680	1.508	0.1138	1.206	1.884	3.606	0.000312	0.9363	0.39926	0.45485	0.3556	63	146	90	46	179	156
  rs6685186	Imputed	T	GEN	680					13.11	0.001423	0.9363	0.39926	0.45485	0.3556	63	146	90	46	179	156
  rs670593	Imputed	A	REC	678	0.594	0.2258	0.3815	0.9244	−2.308	0.02099	0.8731	0.40192	0.38629	0.4142	37	157	105	71	172	136
  rs6722640	Imputed	T	DOM	682	0.696	0.1624	0.5059	0.9562	−2.236	0.02536	0.7521	0.40909	0.37833	0.4332	47	133	120	69	193	120
  rs6746170	Imputed	A	DOM	679	1.647	0.1581	1.208	2.245	3.155	0.001604	0.03549	0.24006	0.27685	0.2113	15	135	148	14	133	234
  rs6757316	Imputed	A	GEN	675					12.53	0.001901	0.4778	0.42222	0.46633	0.3876	73	131	93	52	189	137
  rs6805139	Imputed	G	DOM	681	1.829	0.1922	1.255	2.666	3.141	0.001685	0.4904	0.51101	0.54333	0.4856	78	170	52	95	180	106
  rs6808571	Imputed	G	ADD	675	1.794	0.1564	1.32	2.438	3.736	0.000187	0.5429	0.14889	0.19231	0.1144	13	89	197	4	78	294
  rs6816479	Imputed	A	REC	681	1.903	0.2298	1.213	2.985	2.8	0.005116	0.4521	0.35609	0.36789	0.3469	52	116	131	39	187	156
  rs6865976	Imputed	C	DOM	636	0.514	0.1832	0.3586	0.7355	−3.636	0.000277	0.5254	0.47799	0.42419	0.5195	53	129	95	88	197	74
  rs687047	Imputed	C	ADD	682	0.621	0.1734	0.4423	0.8729	−2.744	0.00607	0.485	0.1261	0.09833	0.1479	1	57	242	12	89	281
  rs6871041	Imputed	G	DOM	625	0.549	0.1652	0.3974	0.7594	−3.626	0.000288	0.7819	0.3176	0.27957	0.3483	28	100	151	33	175	138
  rs688358	Imputed	A	ADD	672	0.627	0.1736	0.4457	0.8804	−2.693	0.007071	0.4853	0.12723	0.09966	0.1489	1	57	238	12	88	276
  rs6908481	Imputed	C	REC	664	2.09	0.2119	1.38	3.166	3.479	0.000503	0.1953	0.39759	0.44138	0.3636	66	124	100	47	178	149
  rs6917224	Imputed	A	ADD	682	1.452	0.1114	1.167	1.806	3.346	0.000821	0.3803	0.40029	0.45167	0.3599	64	143	93	51	173	158
  rs6917224	Imputed	A	GEN	682					11.22	0.003661	0.3803	0.40029	0.45167	0.3599	64	143	93	51	173	158
  rs6920677	Imputed	G	DOM	669	0.657	0.1616	0.4785	0.9016	−2.601	0.009294	0.5131	0.38266	0.3468	0.4113	41	124	132	61	184	127
  rs6994498	Imputed	G	DOM	679	1.535	0.1598	1.122	2.1	2.682	0.007325	0.1286	0.22975	0.25336	0.2113	16	119	163	27	107	247
  rs6998772	Imputed	T	DOM	682	2.585	0.2693	1.525	4.383	3.526	0.000422	0.1493	0.05572	0.07833	0.038	2	43	255	2	25	355
  rs7022281	Imputed	C	ADD	678	0.736	0.1153	0.5872	0.9228	−2.656	0.007896	0.8713	0.38569	0.34783	0.4156	33	142	124	69	177	133
  rs7022281	Imputed	C	GEN	678					7.862	0.01963	0.8713	0.38569	0.34783	0.4156	33	142	124	69	177	133
  rs7022281	Imputed	C	REC	678	0.551	0.2295	0.3514	0.864	−2.597	0.009407	0.8713	0.38569	0.34783	0.4156	33	142	124	69	177	133
  rs7043983	Imputed	T	DOM	678	0.526	0.2092	0.3491	0.7928	−3.07	0.00214	0.6702	0.10103	0.07239	0.1234	2	39	256	6	82	293
  rs7077799	Imputed	A	DOM	682	1.772	0.1576	1.301	2.413	3.63	0.000284	1	0.29692	0.335	0.267	26	149	125	34	136	212
  rs7088947	Imputed	A	ADD	681	0.579	0.2256	0.372	0.9006	−2.424	0.01536	0.3761	0.07122	0.05167	0.0866	0	31	269	5	56	320
  rs7089661	Imputed	C	DOM	682	1.786	0.1574	1.312	2.431	3.685	0.000229	1	0.29545	0.335	0.2644	26	149	125	33	136	213
  rs7102072	Imputed	A	DOM	681	0.569	0.1579	0.4177	0.7758	−3.568	0.00036	0.397	0.28488	0.24167	0.3189	24	97	179	36	171	174
  rs710832	Genotyped	A	REC	682	0.39	0.3429	0.1992	0.7638	−2.746	0.006038	0.2666	0.25293	0.24	0.2631	12	120	168	37	127	218
  rs712531	Imputed	A	DOM	671	1.679	0.1639	1.217	2.315	3.16	0.001579	0.2799	0.36587	0.39691	0.3421	35	161	95	48	164	168
  rs7129817	Imputed	T	ADD	674	0.693	0.1168	0.5509	0.8706	−3.147	0.001649	0.4978	0.34866	0.30201	0.3856	30	120	148	56	178	142
  rs7134262	Imputed	T	GEN	678					19.92	4.72E−05	0.9333	0.35619	0.3796	0.3377	55	117	127	30	196	153
  rs7134262	Imputed	T	REC	678	2.671	0.2439	1.656	4.308	4.027	5.66E−05	0.9333	0.35619	0.3796	0.3377	55	117	127	30	196	153
  rs7138300	Imputed	C	ADD	657	0.709	0.1165	0.5639	0.8903	−2.957	0.003102	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs7138300	Imputed	C	DOM	657	0.595	0.1749	0.4222	0.8382	−2.969	0.002989	0.5823	0.45282	0.41003	0.4864	49	139	101	82	194	92
  rs722927	Imputed	G	ADD	660	0.494	0.2288	0.3152	0.773	−3.085	0.002035	0.2612	0.07652	0.04915	0.0986	1	27	267	5	62	298
  rs722927	Imputed	G	DOM	660	0.474	0.2419	0.2951	0.7616	−3.086	0.002029	0.2612	0.07652	0.04915	0.0986	1	27	267	5	62	298
  rs726424	Genotyped	G	ADD	682	0.709	0.111	0.57	0.8809	−3.102	0.001922	0.02768	0.37757	0.32833	0.4162	35	127	138	76	166	140
  rs726424	Genotyped	G	GEN	682					10.03	0.006653	0.02768	0.37757	0.32833	0.4162	35	127	138	76	166	140
  rs7295817	Imputed	C	ADD	677	0.667	0.1118	0.5356	0.8302	−3.624	0.00029	0.0658	0.40177	0.34343	0.4474	36	132	129	85	170	125
  rs7295817	Imputed	C	GEN	677					13.77	0.001022	0.0658	0.40177	0.34343	0.4474	36	132	129	85	170	125
  rs7295817	Imputed	C	REC	677	0.482	0.218	0.3144	0.739	−3.347	0.000816	0.0658	0.40177	0.34343	0.4474	36	132	129	85	170	125
  rs7297372	Imputed	A	ADD	682	0.69	0.1134	0.5524	0.8617	−3.272	0.001068	0.8151	0.56891	0.52	0.6073	80	152	68	139	186	57
  rs7297372	Imputed	A	GEN	682					10.73	0.00468	0.8151	0.56891	0.52	0.6073	80	152	68	139	186	57
  rs7298255	Imputed	A	ADD	682	0.725	0.1134	0.5804	0.9053	−2.837	0.004558	0.701	0.46701	0.42667	0.4987	57	142	101	89	203	90
  rs7298255	Imputed	A	DOM	682	0.584	0.1737	0.4156	0.8211	−3.095	0.001971	0.701	0.46701	0.42667	0.4987	57	142	101	89	203	90
  rs7305832	Imputed	C	GEN	678					19.92	4.72E−05	0.9333	0.35619	0.3796	0.3377	55	117	127	30	196	153
  rs7305832	Imputed	C	REC	678	2.671	0.2439	1.656	4.308	4.027	5.66E−05	0.9333	0.35619	0.3796	0.3377	55	117	127	30	196	153
  rs737542	Imputed	A	REC	678	1.983	0.312	1.076	3.655	2.194	0.02823	0.8432	0.26327	0.28859	0.2434	28	116	154	20	145	215
  rs742827	Imputed	A	ADD	637	1.408	0.1178	1.118	1.774	2.905	0.003678	0.2603	0.35479	0.40108	0.3189	50	123	105	37	155	167
  rs742827	Imputed	A	GEN	637					8.971	0.01127	0.2603	0.35479	0.40108	0.3189	50	123	105	37	155	167
  rs7446891	Imputed	G	DOM	681	0.561	0.1597	0.4104	0.7675	−3.617	0.000298	0.9326	0.34728	0.30833	0.378	36	113	151	45	198	138
  rs7448641	Imputed	C	ADD	682	0.187	0.4378	0.0793	0.441	−3.83	0.000128	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs7448641	Imputed	C	DOM	682	0.19	0.451	0.0786	0.4606	−3.679	0.000234	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs7460605	Imputed	G	DOM	638	1.639	0.1689	1.177	2.283	2.927	0.003421	0.1625	0.40282	0.43816	0.3746	52	144	87	60	146	149
  rs7468898	Imputed	T	ADD	674	1.412	0.1152	1.127	1.77	2.995	0.002747	0.3143	0.45846	0.50334	0.4227	74	153	72	61	195	119
  rs7468898	Imputed	T	GEN	674					9.55	0.008438	0.3143	0.45846	0.50334	0.4227	74	153	72	61	195	119
  rs7501186	Imputed	A	DOM	677	1.561	0.1787	1.099	2.215	2.49	0.01276	0.5241	0.13959	0.16498	0.1197	8	82	207	7	77	296
  rs755117	Imputed	A	DOM	651	1.658	0.1686	1.192	2.308	2.999	0.002709	0.3232	0.19662	0.22664	0.1727	13	105	171	16	93	253
  rs7557560	Imputed	T	GEN	679					8.554	0.01389	0.9031	0.19514	0.21906	0.1763	18	95	186	7	120	253
  rs7557560	Imputed	T	REC	679	3.783	0.4649	1.521	9.41	2.862	0.004208	0.9031	0.19514	0.21906	0.1763	18	95	186	7	120	253
  rs7562462	Imputed	T	DOM	673	1.896	0.1733	1.35	2.662	3.691	0.000223	0.2091	0.43388	0.48294	0.3961	65	153	75	70	161	149
  rs757173	Genotyped	G	DOM	682	0.544	0.1595	0.398	0.7436	−3.817	0.000135	1	0.36217	0.31	0.4031	32	122	146	57	194	131
  rs7607447	Imputed	T	REC	676	1.87	0.2836	1.073	3.26	2.208	0.02726	0.7777	0.28624	0.29798	0.277	33	111	153	24	162	193
  rs7639053	Imputed	A	ADD	682	1.506	0.1344	1.157	1.96	3.046	0.002322	0.9093	0.21408	0.25167	0.1846	22	107	171	10	121	251
  rs7648163	Imputed	C	REC	654	1.993	0.25	1.221	3.252	2.758	0.005822	0.3754	0.32875	0.34896	0.3128	45	111	132	31	167	168
  rs7651273	Imputed	A	GEN	680					14.12	0.00086	0.08957	0.19779	0.24247	0.1627	26	93	180	8	108	265
  rs7653190	Imputed	C	ADD	677	1.504	0.1347	1.155	1.958	3.029	0.002453	0.9092	0.21492	0.25253	0.1855	22	106	169	10	121	249
  rs7653685	Genotyped	C	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs7684899	Imputed	C	DOM	682	0.713	0.1608	0.5205	0.9774	−2.102	0.03551	0.04848	0.20894	0.18833	0.2251	10	93	197	11	150	221
  rs7701604	Imputed	G	ADD	682	0.187	0.4378	0.0793	0.441	−3.83	0.000128	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs7701604	Imputed	G	DOM	682	0.19	0.451	0.0786	0.4606	−3.679	0.000234	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs7703676	Imputed	C	ADD	682	0.187	0.4378	0.0793	0.441	−3.83	0.000128	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs7703676	Imputed	C	DOM	682	0.19	0.451	0.0786	0.4606	−3.679	0.000234	0.06181	0.03739	0.015	0.055	0	9	291	3	36	343
  rs7711358	Imputed	A	DOM	677	0.564	0.1602	0.4123	0.7725	−3.571	0.000355	1	0.34934	0.30976	0.3803	36	112	149	46	197	137
  rs7713251	Imputed	C	REC	661	2.098	0.2572	1.267	3.474	2.882	0.003956	0.6634	0.33661	0.37075	0.3093	44	130	120	28	171	168
  rs7737608	Imputed	G	DOM	676	1.904	0.164	1.38	2.625	3.926	8.65E−05	0.5601	0.36169	0.41186	0.3228	44	155	96	48	150	183
  rs7755903	Imputed	A	GEN	681					7.188	0.02748	0.9377	0.42805	0.38833	0.4593	44	145	111	80	190	111
  rs7762993	Imputed	A	ADD	677	1.726	0.1392	1.314	2.268	3.921	8.82E−05	0.219	0.19276	0.24074	0.1553	16	111	170	14	90	276
  rs7762993	Imputed	A	DOM	677	2.011	0.1659	1.453	2.784	4.21	2.55E−05	0.219	0.19276	0.24074	0.1553	16	111	170	14	90	276
  rs7767265	Imputed	G	DOM	663	2.106	0.1643	1.526	2.905	4.533	5.81E−06	0.07386	0.22323	0.27875	0.1809	22	116	149	19	98	259
  rs7769415	Imputed	C	GEN	670					4.537	0.1035	0.9297	0.32239	0.34694	0.3032	39	126	129	31	166	179
  rs7771264	Imputed	T	DOM	654	0.635	0.1631	0.4613	0.8744	−2.783	0.005385	1	0.23471	0.2	0.2615	13	88	184	23	147	199
  rs7795792	Imputed	T	REC	679	0.645	0.1981	0.4374	0.9509	−2.214	0.02681	0.01503	0.42636	0.40468	0.4434	50	142	107	89	159	132
  rs7806481	Imputed	G	REC	682	0.439	0.2056	0.2933	0.6567	−4.005	6.20E−05	0.2503	0.47947	0.42667	0.5209	44	168	88	105	188	89
  rs7808536	Imputed	G	DOM	678	1.455	0.1608	1.062	1.995	2.334	0.01962	0.7257	0.20649	0.2291	0.1887	11	115	173	16	111	252
  rs7814819	Imputed	G	ADD	395	2.408	0.2698	1.419	4.086	3.256	0.001129	1	0.08734	0.12431	0.0561	2	41	138	1	22	191
  rs7814819	Imputed	G	DOM	395	2.577	0.2831	1.48	4.488	3.345	0.000824	1	0.08734	0.12431	0.0561	2	41	138	1	22	191
  rs7815952	Imputed	T	DOM	682	2.585	0.2693	1.525	4.383	3.526	0.000422	0.1493	0.05572	0.07833	0.038	2	43	255	2	25	355
  rs7834090	Imputed	T	DOM	682	2.585	0.2693	1.525	4.383	3.526	0.000422	0.1493	0.05572	0.07833	0.038	2	43	255	2	25	355
  rs7859250	Imputed	C	DOM	679	0.52	0.2089	0.345	0.7824	−3.134	0.001722	0.6726	0.10162	0.07239	0.1243	2	39	256	6	83	293
  rs7863577	Genotyped	A	ADD	682	0.48	0.201	0.3239	0.7122	−3.648	0.000264	0.6823	0.10337	0.07	0.1296	1	40	259	7	85	290
  rs7863577	Genotyped	A	DOM	682	0.479	0.2131	0.3153	0.7268	−3.458	0.000545	0.6823	0.10337	0.07	0.1296	1	40	259	7	85	290
  rs7902140	Imputed	C	ADD	673	0.63	0.1425	0.4765	0.8328	−3.244	0.001178	0.1401	0.19539	0.1532	0.2287	6	79	212	26	120	230
  rs7921834	Imputed	C	DOM	682	1.786	0.1574	1.312	2.431	3.685	0.000229	1	0.29545	0.335	0.2644	26	149	125	33	136	213
  rs7939893	Imputed	C	ADD	682	0.707	0.1129	0.5669	0.8826	−3.066	0.002167	0.005005	0.34311	0.29833	0.3783	33	113	154	64	161	157
  rs7939893	Imputed	C	DOM	682	0.641	0.1573	0.4706	0.8718	−2.832	0.004625	0.005005	0.34311	0.29833	0.3783	33	113	154	64	161	157
  rs7955901	Imputed	C	ADD	675	0.723	0.1135	0.579	0.9035	−2.855	0.00431	0.8771	0.46741	0.42617	0.5	57	140	101	89	199	89
  rs7955901	Imputed	C	DOM	675	0.582	0.1743	0.4133	0.8183	−3.11	0.001869	0.8771	0.46741	0.42617	0.5	57	140	101	89	199	89
  rs7956274	Imputed	T	ADD	677	0.74	0.1141	0.5915	0.9251	−2.642	0.00823	0.6995	0.4675	0.42929	0.4974	57	141	99	88	202	90
  rs7956274	Imputed	T	DOM	677	0.598	0.1747	0.4246	0.8421	−2.944	0.003242	0.6995	0.4675	0.42929	0.4974	57	141	99	88	202	90
  rs7957932	Imputed	G	ADD	671	0.738	0.1147	0.5895	0.9243	−2.646	0.008151	0.6433	0.47615	0.4375	0.5067	60	139	97	89	202	84
  rs7957932	Imputed	G	DOM	671	0.57	0.1775	0.4021	0.8065	−3.171	0.001518	0.6433	0.47615	0.4375	0.5067	60	139	97	89	202	84
  rs7984294	Imputed	A	DOM	678	1.497	0.19	1.032	2.173	2.125	0.03361	0.8479	0.11283	0.13255	0.0974	5	69	224	4	66	310
  rs7994286	Imputed	A	ADD	674	0.538	0.1883	0.3721	0.7784	−3.29	0.001	0.2388	0.10979	0.07653	0.1355	3	39	252	8	87	285
  rs7994286	Imputed	A	DOM	674	0.5	0.2066	0.3333	0.7491	−3.358	0.000784	0.2388	0.10979	0.07653	0.1355	3	39	252	8	87	285
  rs8038229	Genotyped	A	ADD	682	0.809	0.1191	0.6403	1.021	−1.783	0.07457	0.2326	0.29545	0.26833	0.3168	26	109	165	40	162	180
  rs8038229	Genotyped	A	DOM	682	0.742	0.1556	0.547	1.007	−1.918	0.05517	0.2326	0.29545	0.26833	0.3168	26	109	165	40	162	180
  rs8043336	Imputed	C	GEN	647					8.706	0.01287	0.9305	0.34312	0.30851	0.3699	21	132	129	56	158	151
  rs8043336	Imputed	C	REC	647	0.449	0.2712	0.264	0.7645	−2.95	0.003176	0.9305	0.34312	0.30851	0.3699	21	132	129	56	158	151
  rs8054431	Imputed	T	DOM	652	1.625	0.1667	1.172	2.253	2.915	0.003561	0.5067	0.38037	0.41434	0.3538	41	155	90	49	161	156
  rs8066502	Imputed	T	DOM	681	0.683	0.1787	0.4814	0.9701	−2.13	0.03319	1	0.14317	0.12667	0.1562	8	60	232	6	107	268
  rs8068714	Imputed	T	DOM	682	0.671	0.1793	0.4725	0.954	−2.223	0.02623	0.8763	0.14223	0.125	0.1558	8	59	233	6	107	269
  rs892575	Imputed	T	ADD	681	1.549	0.1262	1.21	1.984	3.471	0.000519	0.7644	0.25844	0.305	0.2218	28	127	145	19	131	231
  rs892583	Imputed	G	ADD	679	1.541	0.1267	1.202	1.976	3.414	0.00064	0.9202	0.25847	0.30435	0.2224	28	126	145	18	133	229
  rs915494	Imputed	A	ADD	647	1.548	0.1295	1.201	1.995	3.374	0.00074	0.6962	0.27975	0.32517	0.2438	23	140	123	25	126	210
  rs915494	Imputed	A	DOM	647	1.881	0.1622	1.369	2.585	3.896	9.77E−05	0.6962	0.27975	0.32517	0.2438	23	140	123	25	126	210
  rs917295	Imputed	G	DOM	681	0.561	0.1597	0.4104	0.7675	−3.617	0.000298	0.9326	0.34728	0.30833	0.378	36	113	151	45	198	138
  rs922594	Imputed	T	DOM	681	0.735	0.1583	0.5392	1.003	−1.941	0.05228	0.1829	0.35756	0.34281	0.3691	45	115	139	50	182	150
  rs9301653	Imputed	T	ADD	682	0.518	0.1922	0.3551	0.7544	−3.426	0.000612	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs9301653	Imputed	T	DOM	682	0.474	0.2097	0.3145	0.7155	−3.556	0.000376	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs9309988	Imputed	G	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs9309989	Genotyped	C	DOM	682	1.731	0.2018	1.165	2.57	2.718	0.006576	0.1323	0.09824	0.11667	0.0838	2	66	232	8	48	326
  rs9310221	Imputed	A	DOM	631	2.083	0.1765	1.474	2.943	4.157	3.23E−05	0.6253	0.42155	0.46277	0.3883	50	161	71	65	141	143
  rs9327555	Imputed	T	DOM	682	0.56	0.1597	0.4098	0.7664	−3.626	0.000288	0.866	0.34751	0.30833	0.3783	36	113	151	45	199	138
  rs937890	Imputed	G	DOM	638	0.654	0.1848	0.455	0.939	−2.3	0.02143	0.8728	0.14498	0.12633	0.1597	8	55	218	6	102	249
  rs9454967	Imputed	G	ADD	678	2.104	0.213	1.386	3.194	3.492	0.000479	0.6166	0.08481	0.11371	0.062	3	62	234	3	41	335
  rs9454967	Imputed	G	DOM	678	2.304	0.2264	1.478	3.592	3.687	0.000227	0.6166	0.08481	0.11371	0.062	3	62	234	3	41	335
  rs9471295	Imputed	T	DOM	682	1.569	0.1754	1.112	2.213	2.567	0.01026	0.1579	0.14223	0.16667	0.123	5	90	205	4	86	292
  rs9477007	Imputed	A	ADD	651	1.476	0.1133	1.182	1.842	3.433	0.000596	0.225	0.41014	0.46503	0.3671	65	136	85	52	164	149
  rs9477007	Imputed	A	GEN	651					11.79	0.002754	0.225	0.41014	0.46503	0.3671	65	136	85	52	164	149
  rs9487279	Imputed	T	DOM	653	0.61	0.165	0.4417	0.8435	−2.991	0.002778	0.5145	0.3974	0.35986	0.4272	45	118	126	62	187	115
  rs949016	Imputed	C	ADD	682	1.55	0.1262	1.21	1.985	3.473	0.000515	0.7642	0.25806	0.305	0.2212	29	125	146	18	133	231
  rs9555973	Imputed	G	ADD	681	0.538	0.1869	0.3726	0.7754	−3.321	0.000898	0.3277	0.11087	0.07833	0.1365	3	41	256	8	88	285
  rs9555973	Imputed	G	DOM	681	0.501	0.2048	0.3354	0.7487	−3.373	0.000743	0.3277	0.11087	0.07833	0.1365	3	41	256	8	88	285
  rs9557510	Imputed	G	ADD	680	1.629	0.1608	1.188	2.232	3.033	0.002418	0.7519	0.14044	0.17224	0.1155	6	91	202	6	76	299
  rs9557510	Imputed	G	DOM	680	1.768	0.1765	1.251	2.498	3.227	0.001253	0.7519	0.14044	0.17224	0.1155	6	91	202	6	76	299
  rs9560584	Imputed	T	DOM	660	0.489	0.211	0.3233	0.7393	−3.392	0.000695	0.3013	0.10606	0.07388	0.1314	3	37	251	7	83	279
  rs9588770	Imputed	T	DOM	680	0.529	0.2039	0.3549	0.7895	−3.119	0.001815	0.3247	0.11029	0.08	0.1342	3	42	255	8	86	286
  rs9588848	Imputed	C	ADD	682	0.518	0.1922	0.3551	0.7544	−3.426	0.000612	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs9588848	Imputed	C	DOM	682	0.474	0.2097	0.3145	0.7155	−3.556	0.000376	0.3055	0.10484	0.07167	0.1309	3	37	260	7	86	289
  rs966583	Imputed	A	ADD	679	0.729	0.1149	0.5819	0.913	−2.752	0.005926	0.9364	0.40133	0.36409	0.4304	45	127	126	65	198	118
  rs966583	Imputed	A	DOM	679	0.578	0.1648	0.4182	0.7977	−3.332	0.000863	0.9364	0.40133	0.36409	0.4304	45	127	126	65	198	118
  rs974130	Genotyped	A	REC	682	1.891	0.2296	1.206	2.965	2.775	0.005522	0.4535	0.3563	0.36833	0.3469	52	117	131	39	187	156
  rs977160	Imputed	T	ADD	681	1.657	0.1289	1.287	2.133	3.916	8.99E−05	0.919	0.25037	0.30333	0.2087	26	130	144	17	125	239
  rs9812206	Imputed	G	ADD	682	0.481	0.2047	0.3217	0.7177	−3.581	0.000343	0.8253	0.09677	0.06333	0.123	1	36	263	6	82	294
  rs9812206	Imputed	G	DOM	682	0.466	0.215	0.306	0.7107	−3.548	0.000388	0.8253	0.09677	0.06333	0.123	1	36	263	6	82	294
  rs9813552	Imputed	G	ADD	673	0.487	0.2063	0.325	0.7298	−3.487	0.000489	1	0.09658	0.06376	0.1227	1	36	261	5	82	288
  rs9813552	Imputed	G	DOM	673	0.472	0.2155	0.3093	0.7198	−3.486	0.000491	1	0.09658	0.06376	0.1227	1	36	261	5	82	288
  rs9815037	Imputed	T	ADD	682	0.482	0.206	0.3221	0.7224	−3.539	0.000402	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9815037	Imputed	T	DOM	682	0.467	0.215	0.3063	0.7115	−3.543	0.000395	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9825349	Imputed	A	ADD	682	0.482	0.206	0.3221	0.7224	−3.539	0.000402	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9825349	Imputed	A	DOM	682	0.467	0.215	0.3063	0.7115	−3.543	0.000395	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9834217	Imputed	T	ADD	681	0.483	0.206	0.3226	0.7234	−3.532	0.000413	1	0.09618	0.06355	0.1217	1	36	262	5	83	294
  rs9834217	Imputed	T	DOM	681	0.468	0.215	0.3069	0.7127	−3.535	0.000407	1	0.09618	0.06355	0.1217	1	36	262	5	83	294
  rs9840460	Imputed	T	ADD	682	0.482	0.206	0.3221	0.7224	−3.539	0.000402	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9840460	Imputed	T	DOM	682	0.467	0.215	0.3063	0.7115	−3.543	0.000395	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9840756	Imputed	A	ADD	682	0.482	0.206	0.3221	0.7224	−3.539	0.000402	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9840756	Imputed	A	DOM	682	0.467	0.215	0.3063	0.7115	−3.543	0.000395	1	0.09604	0.06333	0.1217	1	36	263	5	83	294
  rs9844801	Imputed	C	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs985375	Imputed	A	GEN	655					11.2	0.003703	0.4705	0.2542	0.2972	0.2209	30	110	146	16	131	222
  rs9869187	Imputed	C	ADD	681	0.488	0.2129	0.3218	0.7413	−3.366	0.000764	0.8111	0.08884	0.05853	0.1126	0	35	264	6	74	302
  rs9869187	Imputed	C	DOM	681	0.497	0.2215	0.3219	0.7671	−3.157	0.001595	0.8111	0.08884	0.05853	0.1126	0	35	264	6	74	302
  rs9872327	Imputed	T	DOM	682	1.705	0.2034	1.144	2.541	2.623	0.008711	0.3705	0.09457	0.11333	0.0798	2	64	234	6	49	327
  rs9881685	Imputed	A	ADD	682	0.481	0.2047	0.3217	0.7177	−3.581	0.000343	0.8253	0.09677	0.06333	0.123	1	36	263	6	82	294
  rs9881685	Imputed	A	DOM	682	0.466	0.215	0.306	0.7107	−3.548	0.000388	0.8253	0.09677	0.06333	0.123	1	36	263	6	82	294
  rs9909499	Imputed	C	DOM	668	1.42	0.1577	1.042	1.934	2.223	0.02622	0.8536	0.2979	0.3266	0.2749	29	136	132	29	146	196
  rs9911847	Imputed	G	DOM	680	0.668	0.1793	0.4702	0.9495	−2.249	0.02452	0.7545	0.14338	0.12667	0.1566	9	58	233	6	107	267
  rs9946886	Imputed	G	REC	232	0.3	0.3567	0.1492	0.6039	−3.374	0.000742	0.08656	0.44828	0.39908	0.4919	13	61	35	40	41	42
  rs9958823	Imputed	A	ADD	679	1.579	0.1261	1.233	2.022	3.624	0.00029	0.6914	0.26068	0.30936	0.2224	30	125	144	18	133	229
  rs9965248	Imputed	T	ADD	671	1.556	0.127	1.213	1.996	3.481	0.0005	0.7646	0.2608	0.30847	0.2234	27	128	140	20	128	228

• TABLE 10
  													PRA-	PLA-	PRA-		PRA-	PLA-		PLA-
  													VA_	CEBO_	VA_	PRA-	VA_	CEBO_	PLA-	CEBO_
  		ALL-									HW_	ALL-	ALL-	ALL-	A1_	VA_	A2_	A1_	CEBO_	A2_
  		ELE	MOD-	N-							PVA	ELE_	ELE_	ELE_	HZ_	HET_	HZ	HZ_	HET_	HZ_
  SNP rs #	SOURCE	(A1)	EL	MISS	OR	SE	L95	U95	STAT	P	LUE	FREQ	FREQ	FREQ	COUNT	COUNT	COUNT	COUNT	COUNT	COUNT

  rs198460	Genotyped	G	REC	383	2.115	0.2449	1.309	3.418	3.058	0.00223	1	0.48695	0.53145	0.45536	50	69	40	41	122	61
  rs603940	Genotyped	G	REC	383	0.5858	0.2988	0.3261	1.052	−1.79	0.07347	0.7489	0.39687	0.36164	0.42188	19	77	63	43	103	78
  rs10021016	Genotyped	G	GEN	383					3.838	0.1467	0.8921	0.25196	0.28931	0.22545	14	64	81	11	79	134
  rs1003148	Imputed	C	ADD	383	0.7355	0.153	0.545	0.9926	−2.009	0.04457	0.9158	0.4047	0.36164	0.43527	22	71	66	40	115	69
  rs1003148	Imputed	C	GEN	383					4.552	0.1027	0.9158	0.4047	0.36164	0.43527	22	71	66	40	115	69
  rs1003148	Imputed	C	REC	383	0.7366	0.2895	0.4176	1.299	−1.056	0.2911	0.9158	0.4047	0.36164	0.43527	22	71	66	40	115	69
  rs10046799	Imputed	C	ADD	381	0.617	0.1556	0.4548	0.837	−3.103	0.00192	0.7499	0.60105	0.53797	0.64574	44	82	32	92	104	27
  rs10046799	Imputed	C	GEN	381					9.722	0.00774	0.7499	0.60105	0.53797	0.64574	44	82	32	92	104	27
  rs10051148	Imputed	C	DOM	383	0.609	0.2097	0.4037	0.9185	−2.365	0.01802	0.6338	0.3107	0.27358	0.33705	16	55	88	23	105	96
  rs10054055	Imputed	T	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.5542	0.31593	0.27987	0.34152	17	55	87	24	105	95
  rs10067895	Imputed	A	DOM	379	0.6022	0.2112	0.398	0.911	−2.401	0.01634	0.724	0.3219	0.28526	0.34753	17	55	84	24	107	92
  rs1008705	Imputed	C	DOM	276	1.451	0.2489	0.8906	2.363	1.495	0.135	0.3442	0.33514	0.36752	0.31132	13	60	44	14	71	74
  rs10105871	Imputed	C	DOM	355	1.427	0.2237	0.9203	2.212	1.589	0.1121	0.3678	0.37887	0.40203	0.36232	23	73	52	32	86	89
  rs10116807	Imputed	A	GEN	376					4.005	0.135	1	0.20346	0.23077	0.18409	10	52	94	5	71	144
  rs10116807	Imputed	A	REC	376	2.952	0.5596	0.9858	8.84	1.934	0.05307	1	0.20346	0.23077	0.18409	10	52	94	5	71	144
  rs10121941	Imputed	C	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs10128638	Genotyped	G	DOM	383	0.6529	0.2374	0.41	1.04	−1.796	0.07252	0.4134	0.50783	0.4717	0.53348	39	72	48	64	111	49
  rs1012924	Imputed	G	ADD	383	0.5758	0.2661	0.3418	0.97	−2.074	0.03805	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs1012924	Imputed	G	DOM	383	0.554	0.2856	0.3166	0.9696	−2.068	0.03864	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs1016030	Genotyped	G	ADD	382	1.554	0.1629	1.129	2.139	2.707	0.0068	0.02038	0.40969	0.46519	0.37054	29	89	40	24	118	82
  rs1016030	Genotyped	G	GEN	382					7.336	0.02553	0.02038	0.40969	0.46519	0.37054	29	89	40	24	118	82
  rs1017558	Imputed	A	REC	382	2.201	0.2868	1.254	3.861	2.75	0.00596	0.8317	0.40052	0.45912	0.35874	35	76	48	25	110	88
  rs10183431	Imputed	T	DOM	383	1.719	0.2141	1.13	2.615	2.53	0.01141	0.6453	0.21149	0.24843	0.18527	6	67	86	9	65	150
  rs10195401	Imputed	C	DOM	377	1.766	0.2208	1.146	2.722	2.575	0.01001	0.00985	0.35544	0.39172	0.32955	14	95	48	22	101	97
  rs10239416	Imputed	A	DOM	381	0.5548	0.2123	0.3659	0.8412	−2.775	0.00553	0.497	0.34646	0.29245	0.38514	16	61	82	33	105	84
  rs1032188	Imputed	G	GEN	381					8.656	0.01319	0.3118	0.28084	0.2327	0.31532	6	62	91	28	84	110
  rs1032188	Imputed	G	REC	381	0.2613	0.4645	0.1051	0.6494	−2.89	0.00386	0.3118	0.28084	0.2327	0.31532	6	62	91	28	84	110
  rs10468988	Imputed	G	ADD	380	1.448	0.1681	1.042	2.013	2.202	0.02767	0.3889	0.29342	0.33228	0.26577	17	71	70	12	94	116
  rs10478919	Imputed	G	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.4104	0.31723	0.28302	0.34152	18	54	87	24	105	95
  rs10506623	Imputed	C	DOM	383	0.6268	0.2197	0.4075	0.9641	−2.126	0.03347	0.133	0.39034	0.34591	0.42188	18	74	67	33	123	68
  rs10506626	Imputed	A	DOM	371	0.5858	0.2268	0.3756	0.9138	−2.358	0.0184	0.0525	0.40296	0.35526	0.43607	18	72	62	33	125	61
  rs10509477	Imputed	T	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs10511071	Imputed	C	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.3464	0.09138	0.12893	0.06473	0	41	118	1	27	196
  rs10511072	Imputed	G	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.3464	0.09138	0.12893	0.06473	0	41	118	1	27	196
  rs10511199	Imputed	C	ADD	379	1.571	0.1825	1.099	2.247	2.475	0.01331	0.3801	0.22559	0.2707	0.19369	10	65	82	6	74	142
  rs10513283	Imputed	G	GEN	383					3.158	0.2061	0.4152	0.19452	0.21384	0.1808	11	46	102	6	69	149
  rs10520072	Imputed	T	DOM	383	0.6021	0.2099	0.3991	0.9085	−2.417	0.01564	0.7244	0.31984	0.28302	0.34598	17	56	86	24	107	93
  rs1065639	Imputed	C	DOM	364	1.785	0.2238	1.151	2.767	2.588	0.00965	0.08775	0.35852	0.40523	0.32464	19	86	48	20	97	94
  rs10733846	Imputed	G	ADD	381	0.6607	0.2049	0.4422	0.9872	−2.023	0.04308	0.3007	0.18241	0.14968	0.20536	3	41	113	6	80	138
  rs10733846	Imputed	G	DOM	381	0.6237	0.2255	0.4009	0.9704	−2.093	0.03632	0.3007	0.18241	0.14968	0.20536	3	41	113	6	80	138
  rs10737390	Imputed	T	DOM	367	0.6571	0.2203	0.4267	1.012	−1.906	0.05666	0.7431	0.39373	0.36218	0.41706	22	69	65	33	110	68
  rs10749293	Imputed	G	DOM	382	1.379	0.2098	0.914	2.08	1.531	0.1257	0.5373	0.29188	0.31761	0.27354	16	69	74	19	84	120
  rs10752159	Imputed	G	DOM	382	1.921	0.2194	1.25	2.953	2.976	0.00292	0.8691	0.19241	0.2327	0.16368	5	64	90	8	57	158
  rs10753760	Imputed	T	ADD	374	1.478	0.1517	1.098	1.99	2.576	0.00999	0.3803	0.37968	0.43506	0.34091	31	72	51	27	96	97
  rs10753760	Imputed	T	GEN	374					6.677	0.0355	0.3803	0.37968	0.43506	0.34091	31	72	51	27	96	97
  rs10757887	Imputed	C	DOM	383	0.5825	0.2158	0.3816	0.8891	−2.505	0.01226	0.1637	0.24021	0.19497	0.27232	9	44	106	18	86	120
  rs10758326	Imputed	A	ADD	382	0.7394	0.1581	0.5424	1.008	−1.91	0.0561	0.2409	0.39921	0.36164	0.42601	19	77	63	36	118	69
  rs10758326	Imputed	A	GEN	382					3.771	0.1518	0.2409	0.39921	0.36164	0.42601	19	77	63	36	118	69
  rs10758326	Imputed	A	REC	382	0.6985	0.3059	0.3835	1.272	−1.173	0.2408	0.2409	0.39921	0.36164	0.42601	19	77	63	36	118	69
  rs10762236	Genotyped	G	ADD	383	0.6676	0.2037	0.4479	0.9952	−1.984	0.04728	0.233	0.18277	0.15094	0.20536	3	42	114	6	80	138
  rs10765769	Imputed	C	ADD	378	1.537	0.1636	1.115	2.118	2.627	0.00862	0.01547	0.42725	0.48089	0.38914	31	89	37	26	120	75
  rs10765769	Imputed	C	GEN	378					6.932	0.03125	1.55E−02	0.42725	0.48089	0.38914	31	89	37	26	120	75
  rs10784891	Imputed	C	ADD	372	0.7477	0.1606	0.5458	1.024	−1.811	0.07022	0.2351	0.40188	0.36129	0.43088	22	68	65	32	123	62
  rs10784891	Imputed	C	DOM	372	0.5753	0.2241	0.3708	0.8925	−2.467	0.01361	0.2351	0.40188	0.36129	0.43088	22	68	65	32	123	62
  rs10787923	Imputed	G	DOM	383	1.391	0.2096	0.9222	2.098	1.574	0.1155	0.5365	0.29112	0.31761	0.27232	16	69	74	19	84	121
  rs10787949	Imputed	A	DOM	382	1.33	0.2097	0.8818	2.006	1.36	0.1737	0.5395	0.29581	0.32075	0.27803	17	68	74	19	86	118
  rs10787951	Imputed	G	DOM	382	1.33	0.2097	0.8818	2.006	1.36	0.1737	0.5395	0.29581	0.32075	0.27803	17	68	74	19	86	118
  rs10787983	Imputed	C	DOM	382	1.351	0.2099	0.8952	2.038	1.432	0.152	0.4588	0.29319	0.31646	0.27679	16	68	74	20	84	120
  rs10788380	Imputed	C	ADD	377	1.299	0.1485	0.9713	1.738	1.764	0.07781	0.6046	0.53581	0.57643	0.50682	51	79	27	60	103	57
  rs10788380	Imputed	C	DOM	377	1.624	0.2633	0.9695	2.721	1.842	0.06541	0.6046	0.53581	0.57643	0.50682	51	79	27	60	103	57
  rs10788380	Imputed	C	GEN	377					3.622	0.1635	0.6046	0.53581	0.57643	0.50682	51	79	27	60	103	57
  rs10814418	Imputed	G	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs10831417	Imputed	A	ADD	383	1.615	0.1632	1.173	2.224	2.937	0.00332	0.02621	0.40862	0.46855	0.36607	30	89	40	23	118	83
  rs10831417	Imputed	A	GEN	383					8.69	0.01297	0.02621	0.40862	0.46855	0.36607	30	89	40	23	118	83
  rs10831422	Imputed	C	ADD	378	1.53	0.1629	1.112	2.106	2.611	0.00902	0.03304	0.40212	0.4557	0.36364	29	86	43	22	116	82
  rs10831422	Imputed	C	GEN	378					7.075	0.02908	0.03304	0.40212	0.4557	0.36364	29	86	43	22	116	82
  rs10862931	Imputed	C	GEN	377					3.939	0.1395	0.4279	0.34748	0.30645	0.37613	15	65	75	34	99	89
  rs10865197	Imputed	C	DOM	383	1.719	0.2141	1.13	2.615	2.53	0.01141	0.6453	0.21149	0.24843	0.18527	6	67	86	9	65	150
  rs10871302	Imputed	A	DOM	382	1.272	0.2475	0.7828	2.066	0.9709	0.3316	0.8085	0.12042	0.13836	0.10762	4	36	119	2	44	177
  rs10877463	Imputed	C	DOM	381	0.5962	0.213	0.3927	0.9052	−2.428	0.0152	0.424	0.3399	0.30063	0.36771	15	65	78	25	114	84
  rs10877468	Imputed	C	DOM	375	0.5825	0.2147	0.3824	0.8872	−2.518	0.01181	0.4237	0.34133	0.3	0.37045	15	63	77	25	113	82
  rs10879240	Imputed	C	ADD	383	0.7632	0.1542	0.5641	1.032	−1.753	0.07966	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs10879242	Imputed	A	DOM	383	0.643	0.2198	0.418	0.9893	−2.009	0.04455	0.1989	0.39426	0.3522	0.42411	19	74	66	34	122	68
  rs10879245	Imputed	G	DOM	383	0.643	0.2198	0.418	0.9893	−2.009	0.04455	0.1989	0.39426	0.3522	0.42411	19	74	66	34	122	68
  rs10879249	Imputed	T	DOM	383	0.6376	0.2187	0.4154	0.9789	−2.057	0.03964	0.1621	0.38903	0.34591	0.41964	18	74	67	33	122	69
  rs10886452	Imputed	A	DOM	382	1.33	0.2097	0.8818	2.006	1.36	0.1737	0.5395	0.29581	0.32075	0.27803	17	68	74	19	86	118
  rs10886463	Imputed	C	DOM	381	1.346	0.21	0.8919	2.032	1.415	0.157	0.3912	0.29659	0.32075	0.27928	17	68	74	20	84	118
  rs10886465	Imputed	A	DOM	383	1.341	0.2095	0.8897	2.022	1.402	0.161	0.3936	0.29634	0.32075	0.27902	17	68	74	20	85	119
  rs10886526	Imputed	C	DOM	381	1.361	0.21	0.9017	2.054	1.467	0.1423	0.3889	0.29265	0.31646	0.27578	16	68	74	20	83	120
  rs10902437	Imputed	G	ADD	355	1.176	0.1625	0.8556	1.618	1	0.3172	0.1268	0.41972	0.44257	0.40338	20	91	37	35	97	75
  rs10941126	Imputed	G	ADD	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs10941126	Imputed	G	DOM	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs10947871	Imputed	A	DOM	383	1.488	0.2326	0.9435	2.348	1.71	0.08731	0.5442	0.14883	0.16667	0.13616	2	49	108	8	45	171
  rs10972978	Imputed	G	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs10973012	Imputed	A	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs10974028	Genotyped	G	ADD	383	0.6345	0.2091	0.4211	0.956	−2.175	0.02963	0.5604	0.15666	0.12264	0.1808	4	31	124	7	67	150
  rs10974028	Genotyped	G	DOM	383	0.5711	0.2392	0.3573	0.9127	−2.342	0.01918	0.5604	0.15666	0.12264	0.1808	4	31	124	7	67	150
  rs11021302	Imputed	A	ADD	378	1.53	0.1629	1.112	2.106	2.611	0.00902	0.03304	0.40212	0.4557	0.36364	29	86	43	22	116	82
  rs11021302	Imputed	A	GEN	378					7.075	0.02908	0.03304	0.40212	0.4557	0.36364	29	86	43	22	116	82
  rs11099644	Imputed	G	REC	382	2.201	0.2868	1.254	3.861	2.75	0.00596	0.8317	0.40052	0.45912	0.35874	35	76	48	25	110	88
  rs11138315	Imputed	G	ADD	364	0.5496	0.2588	0.3309	0.9128	−2.313	0.02075	0.4098	0.10852	0.07566	0.13208	0	23	129	6	44	162
  rs11149802	Imputed	T	DOM	382	1.272	0.2475	0.7828	2.066	0.9709	0.3316	0.8085	0.12042	0.13836	0.10762	4	36	119	2	44	177
  rs1116596	Imputed	T	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.4104	0.31723	0.28302	0.34152	18	54	87	24	105	95
  rs11178531	Imputed	A	ADD	381	0.778	0.1538	0.5755	1.052	−1.632	0.1027	0.5321	0.42913	0.39172	0.45536	27	69	61	40	124	60
  rs11178531	Imputed	A	DOM	381	0.5967	0.2247	0.3841	0.9269	−2.298	0.02156	0.5321	0.42913	0.39172	0.45536	27	69	61	40	124	60
  rs11178575	Imputed	C	GEN	382					2.149	0.3415	0.6639	0.37696	0.39937	0.36099	27	73	59	25	111	87
  rs11178575	Imputed	C	REC	382	1.549	0.3014	0.8578	2.796	1.451	0.1468	0.6639	0.37696	0.39937	0.36099	27	73	59	25	111	87
  rs11178577	Imputed	T	GEN	383					2.22	0.3296	0.6635	0.37728	0.39937	0.36161	27	73	59	25	112	87
  rs11178577	Imputed	T	REC	383	1.557	0.3014	0.8625	2.811	1.469	0.1418	0.6635	0.37728	0.39937	0.36161	27	73	59	25	112	87
  rs11178583	Imputed	A	DOM	383	0.6376	0.2187	0.4154	0.9789	−2.057	0.03964	0.1621	0.38903	0.34591	0.41964	18	74	67	33	122	69
  rs11178589	Imputed	T	DOM	382	0.6428	0.2192	0.4183	0.9878	−2.016	0.0438	0.1627	0.38874	0.34591	0.41928	18	74	67	33	121	69
  rs11178594	Imputed	C	DOM	383	0.6253	0.2193	0.4068	0.9611	−2.141	0.0323	0.133	0.39034	0.34591	0.42188	18	74	67	33	123	68
  rs11178602	Imputed	T	DOM	383	0.6388	0.2189	0.4159	0.9811	−2.047	0.04066	0.1621	0.38903	0.34591	0.41964	18	74	67	33	122	69
  rs11178648	Imputed	T	DOM	382	0.5988	0.2187	0.3901	0.9193	−2.345	0.01904	0.2351	0.38613	0.33861	0.41964	18	71	69	33	122	69
  rs11198877	Imputed	T	DOM	382	1.33	0.2097	0.8818	2.006	1.36	0.1737	0.5395	0.29581	0.32075	0.27803	17	68	74	19	86	118
  rs11198942	Imputed	T	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs11221075	Imputed	A	ADD	378	0.7098	0.2323	0.4502	1.119	−1.475	0.1401	1	0.12434	0.1051	0.13801	2	29	126	4	53	164
  rs11242020	Imputed	T	DOM	382	0.6024	0.2102	0.399	0.9096	−2.411	0.01591	0.4079	0.31675	0.28165	0.34152	18	53	87	24	105	95
  rs11242021	Imputed	T	DOM	381	0.602	0.2105	0.3986	0.9094	−2.411	0.01591	0.7248	0.32152	0.28481	0.34753	17	56	85	24	107	92
  rs11242022	Imputed	T	DOM	380	0.617	0.2103	0.4086	0.9318	−2.296	0.02168	1	0.31316	0.27987	0.3371	16	57	86	21	107	93
  rs11242023	Imputed	T	DOM	379	0.6116	0.2108	0.4046	0.9244	−2.333	0.01964	0.7243	0.31926	0.28481	0.34389	17	56	85	23	106	92
  rs1149350	Imputed	A	DOM	382	1.97	0.2254	1.266	3.065	3.007	0.00264	0.05226	0.17801	0.22327	0.14574	8	55	96	10	45	168
  rs1150143	Imputed	G	DOM	379	1.782	0.2127	1.175	2.704	2.717	0.00659	0.128	0.32586	0.38217	0.28604	24	72	61	23	81	118
  rs11576627	Imputed	T	ADD	383	1.437	0.2014	0.9684	2.132	1.8	0.0718	0.2168	0.14491	0.17296	0.125	6	43	110	5	46	173
  rs11576627	Imputed	T	DOM	383	1.496	0.2351	0.9433	2.371	1.712	0.08693	0.2168	0.14491	0.17296	0.125	6	43	110	5	46	173
  rs11602189	Imputed	A	DOM	374	0.5948	0.2142	0.3909	0.905	−2.426	0.01527	1	0.31818	0.27124	0.35068	12	59	82	26	103	92
  rs11605163	Imputed	A	DOM	376	2.186	0.3185	1.171	4.08	2.455	0.01408	0.3822	0.0625	0.08654	0.04545	0	27	129	0	20	200
  rs11615214	Imputed	G	ADD	382	0.7639	0.1532	0.5657	1.032	−1.758	0.07882	1	0.38874	0.35127	0.41518	21	69	68	37	112	75
  rs11615214	Imputed	G	GEN	382					3.652	0.161	1	0.38874	0.35127	0.41518	21	69	68	37	112	75
  rs11642394	Imputed	C	DOM	383	1.277	0.2476	0.7859	2.074	0.9866	0.3238	0.8082	0.1201	0.13836	0.10714	4	36	119	2	44	178
  rs11644943	Imputed	A	ADD	380	1.606	0.1767	1.136	2.27	2.68	0.00736	0.7774	0.23816	0.28616	0.20362	9	73	77	11	68	142
  rs11656608	Imputed	T	DOM	383	0.7037	0.2279	0.4502	1.1	−1.542	0.1231	0.8589	0.17363	0.15409	0.1875	6	37	116	6	72	146
  rs11661309	Imputed	A	ADD	383	0.5977	0.199	0.4046	0.8827	−2.587	0.00969	0.1541	0.17493	0.13208	0.20536	4	34	121	12	68	144
  rs11661309	Imputed	A	DOM	383	0.5564	0.2336	0.352	0.8796	−2.509	0.0121	0.1541	0.17493	0.13208	0.20536	4	34	121	12	68	144
  rs11666131	Imputed	A	ADD	382	1.578	0.1755	1.119	2.226	2.6	0.00931	0.2905	0.21466	0.26266	0.1808	11	61	86	10	61	153
  rs11743355	Imputed	C	ADD	379	0.2291	0.7784	0.04984	1.054	−1.893	0.05836	1	0.01715	0.00629	0.025	0	2	157	0	11	209
  rs11743355	Imputed	C	DOM	379	0.2291	0.7784	0.04984	1.054	−1.893	0.05836	1	0.01715	0.00629	0.025	0	2	157	0	11	209
  rs11746806	Imputed	T	ADD	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs11746806	Imputed	T	DOM	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs11746959	Imputed	T	ADD	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs11746959	Imputed	T	DOM	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs11749272	Imputed	T	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.4104	0.31723	0.28302	0.34152	18	54	87	24	105	95
  rs11901899	Imputed	A	DOM	378	1.83	0.2121	1.208	2.774	2.851	0.00436	0.1985	0.27646	0.33333	0.23649	18	68	70	16	73	133
  rs11926319	Imputed	G	ADD	380	0.3536	0.2967	0.1977	0.6325	−3.504	0.00046	1	0.09868	0.05414	0.13004	0	17	140	3	52	168
  rs11926319	Imputed	G	DOM	380	0.3514	0.3031	0.194	0.6364	−3.451	0.00056	1	0.09868	0.05414	0.13004	0	17	140	3	52	168
  rs11956952	Imputed	C	DOM	378	0.7003	0.2121	0.4621	1.061	−1.679	0.09313	0.2413	0.26984	0.25478	0.28054	17	46	94	15	94	112
  rs12025826	Imputed	G	DOM	377	1.354	0.2159	0.8867	2.067	1.403	0.1607	0.1274	0.38462	0.39809	0.375	24	77	56	39	87	94
  rs1204522	Imputed	C	GEN	378					3.915	0.1412	0.58	0.36243	0.32595	0.38864	14	75	69	33	105	82
  rs1204524	Imputed	A	GEN	378					3.758	0.1527	0.5784	0.36376	0.32803	0.38914	14	75	68	33	106	82
  rs12153185	Imputed	T	DOM	379	0.6022	0.2112	0.398	0.911	−2.401	0.01634	0.724	0.3219	0.28526	0.34753	17	55	84	24	107	92
  rs12182651	Imputed	T	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs12182651	Imputed	T	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs12193568	Imputed	G	DOM	237	2.406	0.3051	1.323	4.375	2.878	0.00401	0.2704	0.13713	0.18557	0.10357	1	34	62	1	27	112
  rs12264914	Imputed	C	DOM	204	0.7523	0.29	0.4261	1.328	−0.9814	0.3264	0.7359	0.29167	0.2625	0.31048	5	32	43	11	55	58
  rs12307767	Imputed	C	DOM	352	0.5633	0.2206	0.3656	0.868	−2.602	0.00928	0.4648	0.32102	0.27931	0.35024	13	55	77	20	105	82
  rs1232298	Imputed	G	REC	372	2.839	0.3328	1.479	5.45	3.135	0.00172	0.2379	0.32661	0.37742	0.29032	29	59	67	16	94	107
  rs12407412	Imputed	C	ADD	383	1.437	0.2014	0.9684	2.132	1.8	0.0718	0.2168	0.14491	0.17296	0.125	6	43	110	5	46	173
  rs12407412	Imputed	C	DOM	383	1.496	0.2351	0.9433	2.371	1.712	0.08693	0.2168	0.14491	0.17296	0.125	6	43	110	5	46	173
  rs12420184	Imputed	G	DOM	382	0.6069	0.2381	0.3805	0.9678	−2.097	0.03596	0.1285	0.16099	0.1195	0.19058	2	34	123	12	61	150
  rs12422750	Imputed	A	DOM	383	0.5915	0.2116	0.3907	0.8956	−2.481	0.0131	0.2019	0.32637	0.28616	0.35491	13	65	81	22	115	87
  rs12446951	Imputed	A	ADD	266	3.123	0.3652	1.526	6.388	3.118	0.00182	0.1047	0.06767	0.11429	0.03727	3	18	84	0	12	149
  rs12446951	Imputed	A	DOM	266	3.166	0.3883	1.479	6.776	2.968	0.003	0.1047	0.06767	0.11429	0.03727	3	18	84	0	12	149
  rs12457400	Imputed	G	DOM	383	0.6578	0.2682	0.3889	1.113	−1.562	0.1183	0.7834	0.10444	0.08491	0.1183	1	25	133	2	49	173
  rs1247340	Imputed	C	DOM	383	1.98	0.2254	1.273	3.079	3.03	0.00244	0.07793	0.17624	0.22327	0.14286	8	55	96	9	46	169
  rs1247341	Imputed	C	DOM	382	2.017	0.2261	1.295	3.142	3.103	0.00192	0.07501	0.17539	0.22327	0.14126	8	55	96	9	45	169
  rs12521291	Imputed	G	ADD	380	0.6882	0.1569	0.506	0.9361	−2.381	0.01727	0.6567	0.35921	0.3121	0.39238	19	60	78	32	111	80
  rs12526849	Imputed	T	ADD	380	1.357	0.1432	1.025	1.797	2.132	0.03298	0.04681	0.42763	0.47484	0.39367	42	67	50	37	100	84
  rs12526849	Imputed	T	GEN	380					5.531	0.06295	0.04681	0.42763	0.47484	0.39367	42	67	50	37	100	84
  rs12543110	Imputed	G	DOM	383	1.832	0.2138	1.205	2.786	2.832	0.00463	0.4624	0.22454	0.28302	0.18304	14	62	83	8	66	150
  rs12678600	Imputed	A	DOM	381	0.5988	0.211	0.396	0.9055	−2.43	0.01509	0.9081	0.33202	0.28616	0.36486	14	63	82	27	108	87
  rs12719415	Imputed	T	DOM	383	0.6021	0.2099	0.3991	0.9085	−2.417	0.01564	0.7244	0.31984	0.28302	0.34598	17	56	86	24	107	93
  rs12831292	Imputed	G	DOM	382	0.643	0.219	0.4186	0.9878	−2.016	0.04381	0.1627	0.38874	0.34591	0.41928	18	74	67	33	121	69
  rs12923993	Imputed	C	DOM	383	1.277	0.2476	0.7859	2.074	0.9866	0.3238	0.8082	0.1201	0.13836	0.10714	4	36	119	2	44	178
  rs12936964	Imputed	T	DOM	380	1.581	0.2211	1.025	2.439	2.073	0.03817	0.3863	0.38553	0.40823	0.36937	19	91	48	33	98	91
  rs12960663	Imputed	G	ADD	383	0.5977	0.199	0.4046	0.8827	−2.587	0.00969	0.1541	0.17493	0.13208	0.20536	4	34	121	12	68	144
  rs13038146	Imputed	C	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs13038146	Imputed	C	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs13134222	Imputed	A	GEN	382					6.996	0.03026	0.1929	0.23037	0.18553	0.26233	5	49	105	20	77	126
  rs13172910	Imputed	A	DOM	379	0.6946	0.212	0.4585	1.052	−1.719	0.08561	0.2969	0.27045	0.25478	0.28153	17	46	94	15	95	112
  rs13194907	Imputed	A	ADD	383	2.378	0.3248	1.258	4.495	2.668	0.00763	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs13194907	Imputed	A	DOM	383	2.64	0.3358	1.367	5.099	2.891	0.00384	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs13195745	Imputed	A	ADD	383	2.378	0.3248	1.258	4.495	2.668	0.00763	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs13195745	Imputed	A	DOM	383	2.64	0.3358	1.367	5.099	2.891	0.00384	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs1321432	Imputed	A	REC	383	1.784	0.3115	0.9689	3.286	1.859	0.0631	0.3248	0.37206	0.39308	0.35714	26	73	60	22	116	86
  rs1321457	Imputed	G	REC	383	1.704	0.3084	0.9308	3.118	1.728	0.08407	0.6599	0.36684	0.38679	0.35268	26	71	62	23	112	89
  rs13265054	Imputed	T	DOM	381	0.5995	0.211	0.3965	0.9065	−2.425	0.01529	0.9081	0.33202	0.28616	0.36486	14	63	82	27	108	87
  rs13282131	Imputed	C	GEN	383					4.029	0.1334	0.3575	0.4752	0.51887	0.4442	44	77	38	47	105	72
  rs13353526	Imputed	C	DOM	383	2.299	0.2671	1.362	3.881	3.116	0.00183	0.2304	0.0953	0.13208	0.0692	0	42	117	1	29	194
  rs1336382	Imputed	T	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs1336383	Imputed	T	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs1336407	Imputed	T	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs1336409	Imputed	T	DOM	382	1.355	0.2098	0.8985	2.045	1.45	0.1471	0.4624	0.2945	0.31761	0.27803	16	69	74	20	84	119
  rs1336596	Imputed	A	DOM	380	0.6528	0.2133	0.4297	0.9916	−2	0.04554	0.2643	0.35658	0.32595	0.37838	18	67	73	25	118	79
  rs1343560	Imputed	T	ADD	383	0.5758	0.2661	0.3418	0.97	−2.074	0.03805	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs1343560	Imputed	T	DOM	383	0.554	0.2856	0.3166	0.9696	−2.068	0.03864	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs1361987	Imputed	T	GEN	383					3.272	0.1948	0.4362	0.3577	0.3239	0.3817	14	75	70	31	109	84
  rs1386153	Imputed	T	ADD	379	0.6655	0.164	0.4826	0.9177	−2.484	0.01299	0.8128	0.31662	0.26752	0.35135	12	60	85	27	102	93
  rs1386153	Imputed	T	DOM	379	0.5913	0.212	0.3902	0.8959	−2.478	0.01321	0.8128	0.31662	0.26752	0.35135	12	60	85	27	102	93
  rs1394015	Imputed	C	DOM	356	1.898	0.243	1.179	3.056	2.637	0.00837	0.08154	0.41854	0.47569	0.37972	27	83	34	27	107	78
  rs1407038	Imputed	A	REC	382	1.717	0.3085	0.9381	3.144	1.753	0.07963	0.6601	0.36649	0.38608	0.35268	26	70	62	23	112	89
  rs1407039	Imputed	A	REC	379	1.715	0.3088	0.9365	3.142	1.748	0.08054	0.5818	0.37071	0.38854	0.35811	26	70	61	23	113	86
  rs1412802	Imputed	T	GEN	381					5.343	0.06914	0.3707	0.27428	0.2327	0.30405	8	58	93	24	87	111
  rs1414865	Imputed	T	DOM	382	1.33	0.2097	0.8818	2.006	1.36	0.1737	0.5395	0.29581	0.32075	0.27803	17	68	74	19	86	118
  rs1414873	Imputed	A	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs1414876	Imputed	C	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs1418671	Imputed	C	REC	377	2.067	0.2706	1.216	3.513	2.684	0.00728	0.8338	0.43236	0.4557	0.41553	39	66	53	30	122	67
  rs1419490	Genotyped	T	GEN	383					3.125	0.2096	0.4381	0.3564	0.3239	0.37946	14	75	70	31	108	85
  rs1434507	Imputed	A	ADD	381	1.405	0.1664	1.014	1.947	2.044	0.04098	0.5376	0.29396	0.33019	0.26802	17	71	71	13	93	116
  rs1434508	Imputed	T	ADD	382	1.399	0.1663	1.01	1.938	2.018	0.04355	0.5378	0.2945	0.33019	0.26906	17	71	71	13	94	116
  rs1435205	Imputed	A	ADD	379	1.571	0.1825	1.099	2.247	2.475	0.01331	0.3801	0.22559	0.2707	0.19369	10	65	82	6	74	142
  rs1443928	Imputed	C	REC	380	0.5055	0.2469	0.3116	0.8201	−2.763	0.00572	0.5394	0.51579	0.43671	0.57207	31	76	51	73	108	41
  rs1452235	Imputed	G	GEN	383					4.025	0.1337	0.3156	0.35248	0.31132	0.3817	16	67	76	36	99	89
  rs1452236	Imputed	G	GEN	383					4.025	0.1337	0.3156	0.35248	0.31132	0.3817	16	67	76	36	99	89
  rs1452237	Imputed	G	GEN	383					4.025	0.1337	0.3156	0.35248	0.31132	0.3817	16	67	76	36	99	89
  rs1452243	Genotyped	T	GEN	383					4.025	0.1337	0.3156	0.35248	0.31132	0.3817	16	67	76	36	99	89
  rs1463768	Genotyped	G	REC	383	2.557	0.2969	1.429	4.574	3.162	0.00157	0.6662	0.38251	0.41195	0.36161	36	59	64	22	118	84
  rs1463769	Imputed	G	REC	383	2.557	0.2969	1.429	4.574	3.162	0.00157	0.6662	0.38251	0.41195	0.36161	36	59	64	22	118	84
  rs1472435	Imputed	A	ADD	374	0.3624	0.3387	0.1866	0.704	−2.996	0.00274	0.2433	0.07353	0.0414	0.09677	0	13	144	0	42	175
  rs1472435	Imputed	A	DOM	374	0.3624	0.3387	0.1866	0.704	−2.996	0.00274	0.2433	0.07353	0.0414	0.09677	0	13	144	0	42	175
  rs1476714	Imputed	A	DOM	381	0.5994	0.2104	0.3969	0.9054	−2.432	0.01501	0.6369	0.3189	0.28165	0.34529	17	55	86	24	106	93
  rs1495159	Imputed	G	ADD	377	0.6292	0.1647	0.4556	0.8688	−2.814	0.0049	0.01409	0.27454	0.21935	0.31306	11	46	98	27	85	110
  rs1495159	Imputed	G	GEN	377					8.035	0.018	0.01409	0.27454	0.21935	0.31306	11	46	98	27	85	110
  rs1495375	Imputed	A	DOM	383	0.643	0.2198	0.418	0.9893	−2.009	0.04455	0.1989	0.39426	0.3522	0.42411	19	74	66	34	122	68
  rs1495376	Imputed	T	DOM	371	0.4469	0.2418	0.2782	0.7178	−3.331	0.00086	0.7551	0.47844	0.43182	0.51152	35	63	56	48	126	43
  rs1495377	Imputed	G	DOM	370	0.4491	0.2417	0.2797	0.7213	−3.312	0.00093	0.7556	0.47838	0.43182	0.51157	35	63	56	48	125	43
  rs1495381	Imputed	T	GEN	383					5.394	0.06741	0.7553	0.43473	0.46541	0.41295	40	68	51	34	117	73
  rs1495381	Imputed	T	REC	383	1.786	0.2638	1.065	2.996	2.199	0.02786	0.7553	0.43473	0.46541	0.41295	40	68	51	34	117	73
  rs1498992	Imputed	G	DOM	383	0.6967	0.2093	0.4622	1.05	−1.727	0.08421	0.5379	0.29373	0.27358	0.30804	14	59	86	16	106	102
  rs1499001	Imputed	T	DOM	378	0.6855	0.2116	0.4528	1.038	−1.784	0.07436	0.352	0.2619	0.24214	0.27626	11	55	93	11	99	109
  rs1512988	Imputed	A	DOM	380	0.6145	0.2204	0.3989	0.9466	−2.209	0.02719	0.161	0.39079	0.34494	0.42342	18	73	67	33	122	67
  rs1512989	Imputed	T	DOM	380	0.6145	0.2204	0.3989	0.9466	−2.209	0.02719	0.161	0.39079	0.34494	0.42342	18	73	67	33	122	67
  rs1512991	Imputed	T	ADD	382	0.7489	0.1551	0.5526	1.015	−1.864	0.06235	0.5292	0.41623	0.37342	0.44643	25	68	65	38	124	62
  rs1512991	Imputed	T	DOM	382	0.571	0.2227	0.3691	0.8835	−2.516	0.01186	0.5292	0.41623	0.37342	0.44643	25	68	65	38	124	62
  rs1516855	Imputed	G	REC	382	2.635	0.3326	1.373	5.056	2.913	0.00358	0.3164	0.35864	0.38679	0.33857	27	69	63	17	117	89
  rs1527450	Imputed	T	ADD	383	1.615	0.1632	1.173	2.224	2.937	0.00332	0.02621	0.40862	0.46855	0.36607	30	89	40	23	118	83
  rs1527450	Imputed	T	GEN	383					8.69	0.01297	0.02621	0.40862	0.46855	0.36607	30	89	40	23	118	83
  rs1567740	Imputed	T	DOM	381	0.6186	0.2199	0.402	0.9518	−2.185	0.02891	0.1327	0.39108	0.34591	0.42342	18	74	67	33	122	67
  rs1572573	Imputed	A	ADD	362	1.424	0.201	0.9603	2.112	1.759	0.07865	0.2969	0.18646	0.21622	0.16589	3	58	87	6	59	149
  rs1572573	Imputed	A	DOM	362	1.608	0.2249	1.035	2.498	2.112	0.03472	0.2969	0.18646	0.21622	0.16589	3	58	87	6	59	149
  rs1584003	Imputed	C	DOM	380	1.619	0.2537	0.9846	2.661	1.899	0.05761	0.3047	0.49605	0.52548	0.47534	38	89	30	50	112	61
  rs1584005	Imputed	C	DOM	380	1.619	0.2537	0.9846	2.661	1.899	0.05761	0.3047	0.49605	0.52548	0.47534	38	89	30	50	112	61
  rs1585771	Imputed	G	ADD	382	1.485	0.1701	1.064	2.073	2.325	0.02005	0.44	0.27225	0.31646	0.24107	15	70	73	10	88	126
  rs1592015	Imputed	G	DOM	383	0.6821	0.2397	0.4264	1.091	−1.596	0.1105	0.3197	0.15013	0.12579	0.16741	4	32	123	7	61	156
  rs1594885	Imputed	A	ADD	380	1.429	0.1671	1.03	1.983	2.138	0.03253	0.461	0.29737	0.33544	0.27027	17	72	69	13	94	115
  rs1603232	Imputed	A	DOM	370	0.4692	0.2395	0.2935	0.7503	−3.159	0.00158	0.8353	0.47432	0.43137	0.50461	35	62	56	47	125	45
  rs1614565	Imputed	C	DOM	372	0.4727	0.2424	0.2939	0.7602	−3.091	0.00199	0.6778	0.48253	0.44156	0.51147	36	64	54	48	127	43
  rs1648200	Imputed	G	ADD	363	1.513	0.1861	1.05	2.179	2.224	0.02618	0.02626	0.25207	0.29333	0.223	9	70	71	6	83	124
  rs16877387	Imputed	C	GEN	382					6.901	0.03174	0.8277	0.37304	0.40506	0.35045	30	68	60	22	113	89
  rs16877387	Imputed	C	REC	382	2.182	0.3041	1.202	3.961	2.566	0.01029	0.8277	0.37304	0.40506	0.35045	30	68	60	22	113	89
  rs16938626	Imputed	G	DOM	382	0.5784	0.2111	0.3825	0.8747	−2.594	0.00948	0.5218	0.27618	0.23101	0.30804	9	55	94	17	104	103
  rs1694334	Imputed	G	ADD	351	0.6042	0.1961	0.4114	0.8874	−2.569	0.01019	0.7491	0.21225	0.16443	0.24752	6	37	106	11	78	113
  rs16998821	Imputed	C	DOM	383	0.6821	0.2397	0.4264	1.091	−1.596	0.1105	0.3197	0.15013	0.12579	0.16741	4	32	123	7	61	156
  rs1700400	Imputed	T	ADD	362	0.5776	0.1758	0.4093	0.8151	−3.123	0.00179	0.05211	0.25552	0.19156	0.30288	6	47	101	25	76	107
  rs17007620	Imputed	G	ADD	363	1.653	0.1777	1.167	2.341	2.828	0.00468	1	0.24656	0.3	0.20892	13	64	73	9	71	133
  rs17007620	Imputed	G	DOM	363	1.767	0.2175	1.154	2.707	2.619	0.00883	1	0.24656	0.3	0.20892	13	64	73	9	71	133
  rs17023290	Imputed	C	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.3464	0.09138	0.12893	0.06473	0	41	118	1	27	196
  rs17047957	Imputed	C	DOM	383	1.726	0.2428	1.073	2.778	2.249	0.02453	0.4928	0.12924	0.16352	0.10491	5	42	112	3	41	180
  rs1705237	Imputed	A	DOM	369	0.4663	0.2431	0.2895	0.7508	−3.139	0.0017	0.7547	0.48238	0.44079	0.51152	36	62	54	48	126	43
  rs1705261	Imputed	A	GEN	383					5.394	0.06741	0.7553	0.43473	0.46541	0.41295	40	68	51	34	117	73
  rs1705261	Imputed	A	REC	383	1.786	0.2638	1.065	2.996	2.199	0.02786	0.7553	0.43473	0.46541	0.41295	40	68	51	34	117	73
  rs17076972	Imputed	C	ADD	383	1.44	0.1509	1.071	1.935	2.416	0.01568	0.7591	0.46736	0.51887	0.4308	44	77	38	38	117	69
  rs17076972	Imputed	C	GEN	383					6.553	0.03777	0.7591	0.46736	0.51887	0.4308	44	77	38	38	117	69
  rs17076972	Imputed	C	REC	383	1.85	0.2521	1.128	3.032	2.439	0.01473	0.7591	0.46736	0.51887	0.4308	44	77	38	38	117	69
  rs17189710	Imputed	T	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs17189710	Imputed	T	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs17196143	Imputed	A	ADD	383	1.543	0.1879	1.068	2.231	2.308	0.02098	0.869	0.1893	0.22956	0.16071	10	53	96	4	64	156
  rs17353809	Imputed	G	ADD	382	1.616	0.1806	1.134	2.302	2.658	0.00786	0.3892	0.23037	0.27848	0.19643	11	66	81	6	76	142
  rs17368986	Imputed	A	GEN	381					3.069	0.2155	0.4122	0.19423	0.21384	0.18018	11	46	102	6	68	148
  rs17369097	Imputed	A	GEN	383					4.104	0.1285	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs17434511	Imputed	C	GEN	383					3.158	0.2061	0.4152	0.19452	0.21384	0.1808	11	46	102	6	69	149
  rs17434589	Imputed	C	GEN	376					3.386	0.184	0.4114	0.19548	0.2129	0.18326	11	44	100	6	69	146
  rs17434603	Imputed	G	GEN	383					3.158	0.2061	0.4152	0.19452	0.21384	0.1808	11	46	102	6	69	149
  rs17434840	Imputed	C	GEN	383					4.104	0.1285	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs17446418	Imputed	G	DOM	382	0.6878	0.2135	0.4526	1.045	−1.753	0.07956	0.7451	0.38089	0.34906	0.40359	22	67	70	35	110	78
  rs17530747	Imputed	T	DOM	382	0.6878	0.2135	0.4526	1.045	−1.753	0.07956	0.7451	0.38089	0.34906	0.40359	22	67	70	35	110	78
  rs17604285	Imputed	C	ADD	383	0.4148	0.2819	0.2387	0.7208	−3.122	0.0018	0.4026	0.10183	0.06289	0.12946	0	20	139	2	54	168
  rs17604285	Imputed	C	DOM	383	0.4153	0.2867	0.2368	0.7285	−3.065	0.00218	0.4026	0.10183	0.06289	0.12946	0	20	139	2	54	168
  rs17662322	Imputed	T	DOM	383	0.6835	0.2193	0.4447	1.05	−1.735	0.08267	0.526	0.19974	0.17296	0.21875	5	45	109	8	82	134
  rs17769826	Imputed	T	ADD	382	1.616	0.1806	1.134	2.302	2.658	0.00786	0.3892	0.23037	0.27848	0.19643	11	66	81	6	76	142
  rs17821641	Imputed	T	ADD	379	1.571	0.1825	1.099	2.247	2.475	0.01331	0.3801	0.22559	0.2707	0.19369	10	65	82	6	74	142
  rs1782328	Imputed	A	ADD	356	0.5789	0.2144	0.3803	0.8814	−2.549	0.0108	0.4722	0.17978	0.13667	0.21117	3	35	112	6	75	125
  rs1796337	Imputed	T	DOM	379	0.5422	0.239	0.3394	0.8661	−2.561	0.01043	0.8372	0.49208	0.44937	0.52262	37	68	53	56	119	46
  rs1798083	Imputed	C	DOM	370	0.4733	0.2427	0.2942	0.7617	−3.081	0.00206	0.6044	0.48108	0.43791	0.51152	35	64	54	48	126	43
  rs1798085	Imputed	T	DOM	372	0.4727	0.2424	0.2939	0.7602	−3.091	0.00199	0.6778	0.48253	0.44156	0.51147	36	64	54	48	127	43
  rs1798086	Imputed	T	DOM	370	0.4689	0.2427	0.2914	0.7545	−3.12	0.00181	0.7547	0.48243	0.44118	0.51152	36	63	54	48	126	43
  rs1798089	Imputed	C	GEN	371					5.637	0.0597	0.2536	0.469	0.51316	0.43836	46	64	42	41	110	68
  rs1798089	Imputed	C	REC	371	1.806	0.2499	1.106	2.947	2.365	0.01804	0.2536	0.469	0.51316	0.43836	46	64	42	41	110	68
  rs1798090	Imputed	C	GEN	371					5.595	0.06097	0.2992	0.47035	0.51645	0.43836	46	65	41	41	110	68
  rs1798090	Imputed	C	REC	371	1.806	0.2499	1.106	2.947	2.365	0.01804	0.2992	0.47035	0.51645	0.43836	46	65	41	41	110	68
  rs1832222	Imputed	G	DOM	382	1.351	0.2099	0.8952	2.038	1.432	0.152	0.4588	0.29319	0.31646	0.27679	16	68	74	20	84	120
  rs1838104	Imputed	A	ADD	370	0.6393	0.1498	0.4766	0.8574	−2.987	0.00282	0.3479	0.52568	0.46104	0.57176	38	66	50	69	109	38
  rs1838104	Imputed	A	GEN	370					11.02	0.00404	0.3479	0.52568	0.46104	0.57176	38	66	50	69	109	38
  rs1868616	Imputed	G	ADD	372	0.7123	0.1959	0.4852	1.046	−1.732	0.08332	0.3379	0.2043	0.17419	0.22581	4	46	105	8	82	127
  rs1874313	Imputed	A	DOM	382	0.6182	0.22	0.4017	0.9516	−2.185	0.02885	0.1324	0.39136	0.34591	0.42377	18	74	67	33	123	67
  rs1884902	Imputed	C	REC	379	1.796	0.3119	0.9747	3.31	1.878	0.0604	0.4419	0.36939	0.38854	0.35586	26	70	61	22	114	86
  rs1913201	Imputed	G	ADD	383	0.7632	0.1542	0.5641	1.032	−1.753	0.07966	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs1913201	Imputed	G	DOM	383	0.5772	0.2224	0.3733	0.8926	−2.471	0.01349	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs1913201	Imputed	G	GEN	383					6.592	0.03704	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs1944279	Imputed	A	ADD	377	1.444	0.1687	1.038	2.01	2.179	0.02933	0.3868	0.29576	0.33439	0.26818	17	71	69	12	94	114
  rs198461	Imputed	C	DOM	382	0.4755	0.245	0.2942	0.7685	−3.035	0.00241	0.9187	0.51309	0.46855	0.54484	40	69	50	61	121	41
  rs1987179	Imputed	T	DOM	383	0.6667	0.216	0.4366	1.018	−1.877	0.06051	0.7691	0.22324	0.20126	0.23884	10	44	105	10	87	127
  rs1990023	Imputed	T	DOM	382	0.6024	0.2102	0.399	0.9096	−2.411	0.01591	0.4079	0.31675	0.28165	0.34152	18	53	87	24	105	95
  rs2016194	Imputed	G	DOM	381	0.602	0.2105	0.3986	0.9094	−2.411	0.01591	0.7248	0.32152	0.28481	0.34753	17	56	85	24	107	92
  rs2024789	Imputed	C	ADD	381	0.7464	0.1501	0.5562	1.002	−1.949	0.05131	0.9185	0.49081	0.44937	0.52018	31	80	47	60	112	51
  rs2024789	Imputed	C	GEN	381					3.798	0.1497	0.9185	0.49081	0.44937	0.52018	31	80	47	60	112	51
  rs2024902	Imputed	A	ADD	382	2.395	0.3248	1.267	4.526	2.688	0.00718	1	0.05759	0.08544	0.03795	0	27	131	1	15	208
  rs2024902	Imputed	A	DOM	382	2.659	0.3358	1.377	5.135	2.912	0.00359	1	0.05759	0.08544	0.03795	0	27	131	1	15	208
  rs2025107	Imputed	A	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs2025107	Imputed	A	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs2025108	Imputed	T	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs2025108	Imputed	T	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs2062448	Imputed	T	ADD	383	0.4148	0.2819	0.2387	0.7208	−3.122	0.0018	0.4026	0.10183	0.06289	0.12946	0	20	139	2	54	168
  rs2062448	Imputed	T	DOM	383	0.4153	0.2867	0.2368	0.7285	−3.065	0.00218	0.4026	0.10183	0.06289	0.12946	0	20	139	2	54	168
  rs2063591	Imputed	C	ADD	382	0.7711	0.1536	0.5706	1.042	−1.692	0.09058	0.6013	0.42801	0.38924	0.45536	27	69	62	40	124	60
  rs2063591	Imputed	C	DOM	382	0.5884	0.2242	0.3791	0.9131	−2.366	0.018	0.6013	0.42801	0.38924	0.45536	27	69	62	40	124	60
  rs2065604	Imputed	C	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs2066238	Imputed	T	DOM	383	0.6821	0.2397	0.4264	1.091	−1.596	0.1105	0.3197	0.15013	0.12579	0.16741	4	32	123	7	61	156
  rs2068051	Imputed	G	ADD	264	0.6426	0.1952	0.4383	0.9422	−2.265	0.02351	0.06451	0.5	0.45045	0.53595	20	60	31	38	88	27
  rs2068051	Imputed	G	GEN	264					5.343	0.06914	0.06451	0.5	0.45045	0.53595	20	60	31	38	88	27
  rs2077702	Genotyped	G	GEN	383					2.22	0.3296	0.6635	0.37728	0.39937	0.36161	27	73	59	25	112	87
  rs208757	Imputed	G	ADD	345	1.353	0.2024	0.9102	2.012	1.495	0.1348	0.8529	0.17536	0.20139	0.15672	5	48	91	6	51	144
  rs208757	Imputed	G	DOM	345	1.453	0.2347	0.917	2.301	1.591	0.1116	0.8529	0.17536	0.20139	0.15672	5	48	91	6	51	144
  rs2095586	Imputed	A	DOM	382	1.351	0.2099	0.8952	2.038	1.432	0.152	0.4588	0.29319	0.31646	0.27679	16	68	74	20	84	120
  rs2108426	Imputed	C	DOM	381	0.5994	0.2104	0.3969	0.9054	−2.432	0.01501	0.6369	0.3189	0.28165	0.34529	17	55	86	24	106	93
  rs2110664	Imputed	A	DOM	349	1.697	0.2201	1.102	2.613	2.403	0.01627	0.1922	0.28797	0.34028	0.25122	18	62	64	16	71	118
  rs2132242	Imputed	A	DOM	382	0.6291	0.2196	0.4091	0.9676	−2.11	0.03486	0.1617	0.39005	0.34591	0.42152	18	74	67	33	122	68
  rs2151644	Imputed	T	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs2157752	Genotyped	A	GEN	383					3.356	0.1868	0.3575	0.3329	0.30189	0.35491	11	74	74	27	105	92
  rs2158958	Imputed	A	DOM	383	0.6021	0.2099	0.3991	0.9085	−2.417	0.01564	0.7244	0.31984	0.28302	0.34598	17	56	86	24	107	93
  rs2158961	Imputed	G	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.5542	0.31593	0.27987	0.34152	17	55	87	24	105	95
  rs2164099	Imputed	G	ADD	382	1.424	0.1667	1.027	1.974	2.121	0.03389	0.4616	0.29581	0.33333	0.26906	17	72	70	13	94	116
  rs2173254	Imputed	G	GEN	381					4.978	0.08298	0.06174	0.32546	0.30063	0.34305	7	81	70	25	103	95
  rs2173254	Imputed	G	REC	381	0.3756	0.4421	0.1579	0.8933	−2.215	0.02675	0.06174	0.32546	0.30063	0.34305	7	81	70	25	103	95
  rs2188079	Imputed	C	ADD	383	1.5	0.1541	1.109	2.029	2.63	0.00854	0.6716	0.40339	0.45912	0.36384	32	82	45	28	107	89
  rs2188079	Imputed	C	GEN	383					6.918	0.03146	0.6716	0.40339	0.45912	0.36384	32	82	45	28	107	89
  rs2190304	Imputed	G	REC	383	0.628	0.2629	0.3751	1.051	−1.77	0.0768	0.47	0.4517	0.43082	0.46652	27	83	49	55	99	70
  rs2190597	Imputed	T	DOM	381	0.7825	0.223	0.5054	1.211	−1.1	0.2713	0.8344	0.43045	0.4172	0.43973	29	73	55	40	117	67
  rs2190598	Imputed	T	DOM	383	0.6021	0.2099	0.3991	0.9085	−2.417	0.01564	0.7244	0.31984	0.28302	0.34598	17	56	86	24	107	93
  rs2190600	Imputed	A	DOM	379	0.6022	0.2112	0.398	0.911	−2.401	0.01634	0.724	0.3219	0.28526	0.34753	17	55	84	24	107	92
  rs2218084	Imputed	T	GEN	383					6.969	0.03066	0.3636	0.16971	0.21069	0.14063	6	55	98	2	59	163
  rs2218084	Imputed	T	REC	383	4.673	0.8259	0.9259	23.58	1.867	0.06194	0.3636	0.16971	0.21069	0.14063	6	55	98	2	59	163
  rs2236290	Genotyped	C	GEN	381					3.686	0.1583	1	0.37664	0.33861	0.40359	17	73	68	37	106	80
  rs2243860	Imputed	A	GEN	306					4.567	0.1019	1	0.35131	0.39431	0.3224	21	55	47	17	84	82
  rs2243860	Imputed	A	REC	306	2.063	0.3516	1.035	4.108	2.059	0.03949	1	0.35131	0.39431	0.3224	21	55	47	17	84	82
  rs2246564	Imputed	T	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs2248236	Imputed	C	DOM	383	0.6667	0.216	0.4366	1.018	−1.877	0.06051	0.7691	0.22324	0.20126	0.23884	10	44	105	10	87	127
  rs2250340	Imputed	T	DOM	333	0.4723	0.3046	0.26	0.858	−2.463	0.01378	0.3862	0.10511	0.07299	0.12755	2	16	119	3	44	149
  rs2257192	Imputed	G	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs2270584	Imputed	A	DOM	382	0.5988	0.2187	0.3901	0.9193	−2.345	0.01904	0.2351	0.38613	0.33861	0.41964	18	71	69	33	122	69
  rs2270586	Imputed	A	DOM	371	0.5858	0.2268	0.3756	0.9138	−2.358	0.0184	0.0525	0.40296	0.35526	0.43607	18	72	62	33	125	61
  rs2270589	Imputed	A	ADD	308	0.6907	0.1757	0.4895	0.9746	−2.106	0.03518	0.1384	0.4724	0.42188	0.50833	25	58	45	37	109	34
  rs2270589	Imputed	A	DOM	308	0.4396	0.2688	0.2596	0.7445	−3.058	0.00223	0.1384	0.4724	0.42188	0.50833	25	58	45	37	109	34
  rs2270589	Imputed	A	GEN	308					9.89	0.00712	0.1384	0.4724	0.42188	0.50833	25	58	45	37	109	34
  rs2296889	Imputed	C	DOM	381	1.88	0.2321	1.193	2.963	2.721	0.00651	0.6901	0.15223	0.19811	0.11937	7	49	103	3	47	172
  rs2301346	Imputed	C	ADD	343	1.627	0.1791	1.145	2.311	2.717	0.00658	0.2971	0.293	0.34932	0.25127	12	78	56	13	73	111
  rs2301346	Imputed	C	DOM	343	2.008	0.2246	1.293	3.119	3.103	0.00191	0.2971	0.293	0.34932	0.25127	12	78	56	13	73	111
  rs2327929	Imputed	G	REC	383	1.756	0.2541	1.068	2.89	2.217	0.02662	0.8372	0.45431	0.47799	0.4375	42	68	49	38	120	66
  rs2357486	Imputed	C	REC	379	1.682	0.4091	0.7542	3.75	1.27	0.2039	0.00149	0.32322	0.33228	0.31674	14	77	67	12	116	93
  rs2373793	Imputed	G	DOM	374	1.775	0.2221	1.149	2.743	2.583	0.00978	0.6199	0.19251	0.22549	0.16968	4	61	88	8	59	154
  rs2377622	Imputed	T	GEN	283					3.778	0.1513	0.6851	0.32686	0.28205	0.35843	9	48	60	23	73	70
  rs2377622	Imputed	T	REC	283	0.5046	0.4168	0.2229	1.142	−1.641	0.1008	0.6851	0.32686	0.28205	0.35843	9	48	60	23	73	70
  rs2383903	Imputed	G	DOM	381	0.5866	0.211	0.3879	0.8871	−2.528	0.01148	0.444	0.27822	0.23418	0.30942	9	56	93	17	104	102
  rs2389866	Imputed	C	DOM	383	0.6667	0.216	0.4366	1.018	−1.877	0.06051	0.7691	0.22324	0.20126	0.23884	10	44	105	10	87	127
  rs2389869	Imputed	C	DOM	383	0.6667	0.216	0.4366	1.018	−1.877	0.06051	0.7691	0.22324	0.20126	0.23884	10	44	105	10	87	127
  rs2418541	Imputed	A	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.4104	0.31723	0.28302	0.34152	18	54	87	24	105	95
  rs2418542	Imputed	A	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.4104	0.31723	0.28302	0.34152	18	54	87	24	105	95
  rs2418548	Imputed	C	DOM	378	0.6382	0.211	0.4221	0.965	−2.129	0.03326	0.4132	0.32672	0.29618	0.34842	19	55	83	25	104	92
  rs2476976	Imputed	C	DOM	382	1.351	0.2099	0.8952	2.038	1.432	0.152	0.4588	0.29319	0.31646	0.27679	16	68	74	20	84	120
  rs2483639	Imputed	A	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs2483640	Imputed	A	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs2544780	Imputed	T	REC	381	1.683	0.3502	0.8473	3.344	1.487	0.137	0.7246	0.3189	0.32166	0.31696	20	61	76	17	108	99
  rs2586458	Imputed	T	DOM	323	0.4393	0.2682	0.2597	0.7431	−3.067	0.00216	0.65	0.14396	0.09929	0.17857	2	24	115	3	59	120
  rs2593272	Imputed	G	ADD	383	0.5962	0.1685	0.4285	0.8294	−3.07	0.00214	0.05071	0.26762	0.2044	0.3125	7	51	101	28	84	112
  rs2593273	Imputed	T	ADD	383	0.5962	0.1685	0.4285	0.8294	−3.07	0.00214	0.05071	0.26762	0.2044	0.3125	7	51	101	28	84	112
  rs2622499	Imputed	G	DOM	383	0.6667	0.216	0.4366	1.018	−1.877	0.06051	0.7691	0.22324	0.20126	0.23884	10	44	105	10	87	127
  rs264126	Imputed	C	DOM	381	0.7975	0.2216	0.5165	1.231	−1.022	0.307	1	0.42782	0.4172	0.43527	30	71	56	40	115	69
  rs264129	Imputed	T	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.5542	0.31593	0.27987	0.34152	17	55	87	24	105	95
  rs2656822	Imputed	T	ADD	383	0.5962	0.1685	0.4285	0.8294	−3.07	0.00214	0.05071	0.26762	0.2044	0.3125	7	51	101	28	84	112
  rs2656823	Imputed	G	ADD	383	0.5962	0.1685	0.4285	0.8294	−3.07	0.00214	0.05071	0.26762	0.2044	0.3125	7	51	101	28	84	112
  rs2656825	Imputed	T	ADD	362	0.558	0.1868	0.387	0.8047	−3.123	0.00179	0.4731	0.23895	0.17763	0.28333	3	48	101	20	79	111
  rs2764766	Imputed	C	REC	383	1.776	0.3462	0.901	3.5	1.659	0.09717	0.8147	0.32115	0.32704	0.31696	21	62	76	17	108	99
  rs2793101	Imputed	T	ADD	383	0.6263	0.2568	0.3786	1.036	−1.822	0.06842	0.2863	0.10705	0.08491	0.12277	1	25	133	1	53	170
  rs2793101	Imputed	T	DOM	383	0.5997	0.2668	0.3555	1.012	−1.916	0.05534	0.2863	0.10705	0.08491	0.12277	1	25	133	1	53	170
  rs2795871	Imputed	A	ADD	382	0.3627	0.3488	0.1831	0.7186	−2.908	0.00364	0.2402	0.06806	0.03774	0.08969	0	12	147	0	40	183
  rs2795886	Imputed	A	ADD	383	0.3343	0.376	0.16	0.6986	−2.914	0.00357	0.3826	0.06005	0.03145	0.08036	0	10	149	0	36	188
  rs2795886	Imputed	A	DOM	383	0.3343	0.376	0.16	0.6986	−2.914	0.00357	0.3826	0.06005	0.03145	0.08036	0	10	149	0	36	188
  rs2859994	Imputed	C	GEN	378					6.173	0.04567	0.2908	0.41931	0.47115	0.38288	33	81	42	28	114	80
  rs2870464	Imputed	G	DOM	383	1.373	0.2699	0.8092	2.331	1.176	0.2398	0.7607	0.09399	0.11006	0.08259	2	31	126	2	33	189
  rs2875528	Imputed	T	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.3464	0.09138	0.12893	0.06473	0	41	118	1	27	196
  rs2876227	Imputed	C	ADD	380	1.396	0.1502	1.04	1.874	2.221	0.02634	0.1846	0.36579	0.41026	0.33482	27	74	55	30	90	104
  rs2876227	Imputed	C	GEN	380					5.549	0.06238	0.1846	0.36579	0.41026	0.33482	27	74	55	30	90	104
  rs2882097	Imputed	A	DOM	383	1.367	0.2096	0.9065	2.062	1.491	0.1358	0.4613	0.29373	0.31761	0.27679	16	69	74	20	84	120
  rs2921983	Imputed	C	ADD	375	0.5761	0.1731	0.4103	0.8087	−3.187	0.00144	0.04386	0.26	0.19355	0.30682	6	48	101	27	81	112
  rs2987537	Imputed	C	DOM	383	0.5886	0.2614	0.3526	0.9826	−2.027	0.04264	0.8057	0.1188	0.09119	0.13839	2	25	132	4	54	166
  rs2996416	Imputed	C	ADD	382	0.5791	0.2661	0.3437	0.9755	−2.053	0.04007	0.7684	0.09686	0.06962	0.11607	1	20	137	3	46	175
  rs2996416	Imputed	C	DOM	382	0.5573	0.2856	0.3184	0.9754	−2.047	0.04066	0.7684	0.09686	0.06962	0.11607	1	20	137	3	46	175
  rs3015527	Imputed	C	ADD	377	0.5922	0.2667	0.3511	0.9989	−1.964	0.04953	0.7661	0.09682	0.07051	0.11538	1	20	135	3	45	173
  rs3015527	Imputed	C	DOM	377	0.572	0.2869	0.326	1.004	−1.947	0.05151	0.7661	0.09682	0.07051	0.11538	1	20	135	3	45	173
  rs3015530	Imputed	C	ADD	383	0.5758	0.2661	0.3418	0.97	−2.074	0.03805	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs3015530	Imputed	C	DOM	383	0.554	0.2856	0.3166	0.9696	−2.068	0.03864	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs3015531	Imputed	T	ADD	383	0.5758	0.2661	0.3418	0.97	−2.074	0.03805	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs3015531	Imputed	T	DOM	383	0.554	0.2856	0.3166	0.9696	−2.068	0.03864	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs3015535	Imputed	C	ADD	383	0.5758	0.2661	0.3418	0.97	−2.074	0.03805	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs3015535	Imputed	C	DOM	383	0.554	0.2856	0.3166	0.9696	−2.068	0.03864	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs3019407	Imputed	A	GEN	381					5.56	0.06205	0.1023	0.32546	0.30063	0.34305	7	81	70	26	101	96
  rs3019407	Imputed	A	REC	381	0.3598	0.4403	0.1518	0.8529	−2.321	0.02026	0.1023	0.32546	0.30063	0.34305	7	81	70	26	101	96
  rs36071725	Genotyped	C	GEN	383					4.835	0.08914	0.9112	0.35248	0.39623	0.32143	24	78	57	24	96	104
  rs373983	Imputed	G	DOM	380	1.266	0.2223	0.8189	1.957	1.061	0.2888	0.7504	0.41053	0.42038	0.40359	24	84	49	38	104	81
  rs3756154	Imputed	C	DOM	383	0.6667	0.216	0.4366	1.018	−1.877	0.06051	0.7691	0.22324	0.20126	0.23884	10	44	105	10	87	127
  rs3793044	Imputed	C	ADD	383	2.378	0.3248	1.258	4.495	2.668	0.00763	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs3793044	Imputed	C	DOM	383	2.64	0.3358	1.367	5.099	2.891	0.00384	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs3793053	Imputed	C	ADD	380	2.28	0.3065	1.25	4.157	2.689	0.00717	0.1626	0.06184	0.09177	0.04054	1	27	130	2	14	206
  rs3793053	Imputed	C	DOM	380	2.764	0.3341	1.436	5.32	3.042	0.00235	0.1626	0.06184	0.09177	0.04054	1	27	130	2	14	206
  rs3796246	Imputed	G	ADD	383	0.3513	0.2964	0.1965	0.6279	−3.53	0.00042	1	0.09791	0.05346	0.12946	0	17	142	3	52	169
  rs3796246	Imputed	G	DOM	383	0.3489	0.3028	0.1928	0.6316	−3.478	0.00051	1	0.09791	0.05346	0.12946	0	17	142	3	52	169
  rs3805996	Imputed	G	ADD	382	2.395	0.3248	1.267	4.526	2.688	0.00718	1	0.05759	0.08544	0.03795	0	27	131	1	15	208
  rs3805996	Imputed	G	DOM	382	2.659	0.3358	1.377	5.135	2.912	0.00359	1	0.05759	0.08544	0.03795	0	27	131	1	15	208
  rs3806003	Imputed	A	ADD	383	2.378	0.3248	1.258	4.495	2.668	0.00763	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs3806003	Imputed	A	DOM	383	2.64	0.3358	1.367	5.099	2.891	0.00384	1	0.05744	0.08491	0.03795	0	27	132	1	15	208
  rs3806004	Imputed	T	ADD	382	2.473	0.3048	1.361	4.493	2.97	0.00298	0.193	0.06414	0.0981	0.04018	1	29	128	2	14	208
  rs3806004	Imputed	T	DOM	382	3.015	0.3305	1.578	5.763	3.339	0.00084	0.193	0.06414	0.0981	0.04018	1	29	128	2	14	208
  rs3806010	Imputed	T	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806010	Imputed	T	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806014	Imputed	T	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806014	Imputed	T	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806015	Imputed	A	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806015	Imputed	A	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806018	Imputed	A	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806018	Imputed	A	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806019	Imputed	A	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806019	Imputed	A	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs3806024	Imputed	T	ADD	382	2.274	0.3063	1.248	4.146	2.682	0.00732	0.1608	0.06152	0.09119	0.04036	1	27	131	2	14	207
  rs3806024	Imputed	T	DOM	382	2.756	0.334	1.432	5.303	3.035	0.0024	0.1608	0.06152	0.09119	0.04036	1	27	131	2	14	207
  rs3847825	Imputed	G	ADD	382	0.7535	0.1544	0.5568	1.02	−1.833	0.06673	0.9143	0.39005	0.35127	0.41741	21	69	68	36	115	73
  rs3847825	Imputed	G	GEN	382					4.284	0.1174	0.9143	0.39005	0.35127	0.41741	21	69	68	36	115	73
  rs3852001	Genotyped	C	GEN	383					4.104	0.1285	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs3852001	Genotyped	C	REC	383	2.797	0.5134	1.023	7.653	2.004	0.04512	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs3852002	Imputed	G	GEN	383					4.104	0.1285	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs3852002	Imputed	G	REC	383	2.797	0.5134	1.023	7.653	2.004	0.04512	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs3852003	Imputed	A	GEN	383					4.104	0.1285	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs3852003	Imputed	A	REC	383	2.797	0.5134	1.023	7.653	2.004	0.04512	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs3942254	Imputed	T	DOM	351	0.5955	0.227	0.3817	0.9293	−2.283	0.02242	0.737	0.38746	0.33916	0.42067	18	61	64	33	109	66
  rs3945085	Imputed	A	DOM	383	1.391	0.2096	0.9222	2.098	1.574	0.1155	0.5365	0.29112	0.31761	0.27232	16	69	74	19	84	121
  rs399485	Imputed	A	DOM	382	1.379	0.2101	0.9136	2.082	1.53	0.126	0.6346	0.31283	0.33648	0.29596	15	77	67	20	92	111
  rs4029119	Imputed	G	ADD	382	0.1157	1.052	0.01473	0.9094	−2.05	0.04034	1	0.01571	0.00316	0.02455	0	1	157	0	11	213
  rs4029119	Imputed	G	DOM	382	0.1157	1.052	0.01473	0.9094	−2.05	0.04034	1	0.01571	0.00316	0.02455	0	1	157	0	11	213
  rs412791	Imputed	C	GEN	367					2.832	0.2427	0.5643	0.34605	0.31731	0.3673	13	73	70	28	99	84
  rs4146972	Genotyped	T	DOM	383	1.672	0.2418	1.041	2.685	2.125	0.03357	0.4985	0.13055	0.16352	0.10714	5	42	112	3	42	179
  rs4259369	Imputed	C	REC	383	0.4161	0.2795	0.2406	0.7196	−3.137	0.00171	0.6078	0.46867	0.39937	0.51786	21	85	53	60	112	52
  rs4273613	Imputed	T	ADD	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs4273613	Imputed	T	DOM	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs4294022	Imputed	C	DOM	383	0.5507	0.2147	0.3616	0.8388	−2.779	0.00546	0.3404	0.25065	0.21384	0.27679	9	50	100	11	102	111
  rs4310554	Genotyped	C	DOM	383	1.609	0.2628	0.9616	2.694	1.811	0.07014	0.681	0.53786	0.57547	0.51116	51	81	27	62	105	57
  rs4315598	Imputed	T	ADD	382	1.42	0.1496	1.06	1.904	2.347	0.01894	0.1477	0.35864	0.40566	0.32511	27	75	57	29	87	107
  rs4315598	Imputed	T	GEN	382					6.306	0.04271	0.1477	0.35864	0.40566	0.32511	27	75	57	29	87	107
  rs4370878	Imputed	G	DOM	383	1.391	0.2096	0.9222	2.098	1.574	0.1155	0.5365	0.29112	0.31761	0.27232	16	69	74	19	84	121
  rs4436200	Imputed	C	ADD	383	0.5856	0.2343	0.37	0.9269	−2.284	0.02238	0.6515	0.12794	0.09434	0.15179	0	30	129	7	54	163
  rs4444612	Imputed	G	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs4444612	Imputed	G	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs4450660	Imputed	C	DOM	383	1.719	0.2141	1.13	2.615	2.53	0.01141	0.6453	0.21149	0.24843	0.18527	6	67	86	9	65	150
  rs4463950	Imputed	C	DOM	379	0.5555	0.2195	0.3613	0.8542	−2.678	0.00741	0.05998	0.43272	0.37342	0.47511	27	64	67	53	104	64
  rs4509702	Imputed	C	DOM	383	1.391	0.2096	0.9222	2.098	1.574	0.1155	0.5365	0.29112	0.31761	0.27232	16	69	74	19	84	121
  rs4533379	Imputed	G	ADD	380	1.429	0.1671	1.03	1.983	2.138	0.03253	0.461	0.29737	0.33544	0.27027	17	72	69	13	94	115
  rs4569984	Imputed	A	DOM	374	0.5254	0.2168	0.3436	0.8036	−2.969	0.00299	0.2184	0.25401	0.21474	0.28211	9	49	98	10	103	105
  rs4570530	Imputed	C	DOM	383	1.391	0.2096	0.9222	2.098	1.574	0.1155	0.5365	0.29112	0.31761	0.27232	16	69	74	19	84	121
  rs4571583	Imputed	T	DOM	383	0.5381	0.2149	0.3531	0.8199	−2.884	0.00392	0.2723	0.24804	0.21069	0.27455	9	49	101	10	103	111
  rs4586678	Imputed	A	DOM	383	1.719	0.2141	1.13	2.615	2.53	0.01141	0.6453	0.21149	0.24843	0.18527	6	67	86	9	65	150
  rs4615971	Imputed	C	DOM	382	1.351	0.2099	0.8952	2.038	1.432	0.152	0.4588	0.29319	0.31646	0.27679	16	68	74	20	84	120
  rs4629229	Imputed	G	DOM	383	0.6821	0.2397	0.4264	1.091	−1.596	0.1105	0.3197	0.15013	0.12579	0.16741	4	32	123	7	61	156
  rs4632512	Imputed	T	GEN	383					4.104	0.1285	0.3319	0.19713	0.21698	0.18304	12	45	102	6	70	148
  rs4641552	Imputed	A	ADD	377	0.5381	0.2751	0.3138	0.9226	−2.253	0.02427	1	0.09682	0.06731	0.11765	1	19	136	2	48	171
  rs4682527	Imputed	C	DOM	364	1.785	0.2238	1.151	2.767	2.588	0.00965	0.08775	0.35852	0.40523	0.32464	19	86	48	20	97	94
  rs4688632	Imputed	G	REC	373	0.656	0.2381	0.4113	1.046	−1.77	0.07666	0.12	0.52145	0.49026	0.54338	37	77	40	72	94	53
  rs4702720	Imputed	A	ADD	320	0.6922	0.2059	0.4623	1.036	−1.787	0.07392	0.7262	0.2	0.16541	0.2246	3	38	92	11	62	114
  rs4702720	Imputed	A	DOM	320	0.7001	0.2406	0.4369	1.122	−1.481	0.1385	0.7262	0.2	0.16541	0.2246	3	38	92	11	62	114
  rs4714484	Imputed	A	ADD	383	0.5988	0.1942	0.4093	0.8761	−2.641	0.00827	0.1255	0.18538	0.13836	0.21875	6	32	121	12	74	138
  rs4714484	Imputed	A	DOM	383	0.5097	0.2319	0.3235	0.803	−2.906	0.00366	0.1255	0.18538	0.13836	0.21875	6	32	121	12	74	138
  rs4725142	Genotyped	G	REC	383	0.3868	0.3771	0.1847	0.81	−2.519	0.01178	0.9099	0.34204	0.3239	0.35491	10	83	66	34	91	99
  rs4725144	Imputed	G	REC	383	0.3868	0.3771	0.1847	0.81	−2.519	0.01178	0.9099	0.34204	0.3239	0.35491	10	83	66	34	91	99
  rs4760785	Imputed	A	ADD	383	0.7632	0.1542	0.5641	1.032	−1.753	0.07966	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs4760785	Imputed	A	DOM	383	0.5772	0.2224	0.3733	0.8926	−2.471	0.01349	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs4760894	Imputed	T	ADD	383	0.7632	0.1542	0.5641	1.032	−1.753	0.07966	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs4760894	Imputed	T	DOM	383	0.5772	0.2224	0.3733	0.8926	−2.471	0.01349	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs4760895	Imputed	A	ADD	383	0.7632	0.1542	0.5641	1.032	−1.753	0.07966	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs4760895	Imputed	A	DOM	383	0.5772	0.2224	0.3733	0.8926	−2.471	0.01349	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs4767184	Imputed	C	ADD	375	0.7432	0.1558	0.5476	1.009	−1.905	0.05677	1	0.392	0.35065	0.42081	21	66	67	36	114	71
  rs4767184	Imputed	C	GEN	375					4.92	0.08545	1	0.392	0.35065	0.42081	21	66	67	36	114	71
  rs4773487	Imputed	T	ADD	380	0.5534	0.2659	0.3287	0.932	−2.225	0.02609	0.7794	0.1	0.07006	0.12108	1	20	136	3	48	172
  rs4780547	Imputed	G	GEN	382					1.722	0.4228	1	0.22644	0.21519	0.23438	5	58	95	14	77	133
  rs4780547	Imputed	G	REC	382	0.5086	0.5339	0.1786	1.448	−1.266	0.2054	1	0.22644	0.21519	0.23438	5	58	95	14	77	133
  rs483159	Imputed	T	DOM	369	1.242	0.2188	0.8087	1.906	0.9893	0.3225	0.7497	0.20461	0.21711	0.19585	5	56	91	9	67	141
  rs4836502	Imputed	T	DOM	383	0.6021	0.2099	0.3991	0.9085	−2.417	0.01564	0.7244	0.31984	0.28302	0.34598	17	56	86	24	107	93
  rs4836507	Imputed	C	DOM	376	0.6042	0.212	0.3988	0.9154	−2.377	0.01745	0.5558	0.32048	0.28387	0.34615	17	54	84	24	105	92
  rs4851531	Imputed	T	DOM	380	0.5595	0.2166	0.366	0.8553	−2.682	0.00733	0.665	0.38553	0.35127	0.40991	24	63	71	30	122	70
  rs4879931	Imputed	G	ADD	382	0.7554	0.1662	0.5453	1.046	−1.688	0.09145	0.2407	0.32199	0.28931	0.34529	12	68	79	22	110	91
  rs489441	Imputed	G	ADD	357	1.491	0.172	1.064	2.089	2.322	0.02024	0.4487	0.29552	0.34354	0.2619	16	69	62	12	86	112
  rs489441	Imputed	G	DOM	357	1.551	0.2175	1.013	2.376	2.018	0.04362	0.4487	0.29552	0.34354	0.2619	16	69	62	12	86	112
  rs4976276	Imputed	T	ADD	382	1.499	0.1578	1.1	2.042	2.566	0.01029	0.6569	0.35995	0.41456	0.32143	24	83	51	23	98	103
  rs4977681	Imputed	C	REC	380	2.078	0.3396	1.068	4.042	2.153	0.03132	0.1768	0.34868	0.37898	0.32735	23	73	61	17	112	94
  rs4986197	Imputed	G	ADD	379	1.42	0.1672	1.023	1.97	2.097	0.03598	0.4609	0.29683	0.33439	0.27027	17	71	69	13	94	115
  rs4986220	Imputed	T	ADD	383	1.437	0.1677	1.034	1.996	2.162	0.03065	0.3893	0.29243	0.33019	0.26563	17	71	71	12	95	117
  rs525462	Imputed	A	GEN	382					9.552	0.00843	0.9148	0.6034	0.54088	0.64798	45	82	32	93	103	27
  rs552006	Imputed	G	GEN	380					6.857	0.03243	0.3034	0.27237	0.31447	0.24208	16	68	75	8	91	122
  rs5756669	Imputed	C	DOM	383	1.639	0.2271	1.05	2.558	2.175	0.02962	0.8346	0.42428	0.44654	0.40848	27	88	44	43	97	84
  rs581905	Imputed	T	DOM	383	1.341	0.2854	0.7666	2.347	1.029	0.3036	0.7263	0.08094	0.09119	0.07366	1	27	131	2	29	193
  rs6033138	Imputed	C	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6033138	Imputed	C	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040619	Imputed	C	ADD	374	1.432	0.1515	1.064	1.927	2.368	0.01789	0.1811	0.3623	0.41026	0.32798	27	74	55	28	87	103
  rs6040619	Imputed	C	GEN	374					6.205	0.04493	0.1811	0.3623	0.41026	0.32798	27	74	55	28	87	103
  rs6040625	Imputed	T	ADD	380	1.45	0.1506	1.079	1.947	2.466	0.01364	0.1459	0.35658	0.40705	0.32143	27	73	56	28	88	108
  rs6040625	Imputed	T	GEN	380					6.611	0.03669	0.1459	0.35658	0.40705	0.32143	27	73	56	28	88	108
  rs6040630	Imputed	A	ADD	383	1.444	0.1501	1.076	1.938	2.448	0.01435	0.1808	0.3564	0.40566	0.32143	27	75	57	28	88	108
  rs6040630	Imputed	A	GEN	383					6.635	0.03624	0.1808	0.3564	0.40566	0.32143	27	75	57	28	88	108
  rs6040633	Imputed	A	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040633	Imputed	A	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040634	Imputed	T	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040634	Imputed	T	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040636	Imputed	T	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040636	Imputed	T	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040638	Imputed	C	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040638	Imputed	C	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040644	Imputed	A	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040644	Imputed	A	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6040667	Imputed	T	ADD	381	1.419	0.1495	1.058	1.902	2.339	0.01935	0.09512	0.35696	0.40446	0.32366	27	73	57	29	87	108
  rs6040667	Imputed	T	GEN	381					6.102	0.04731	0.09512	0.35696	0.40446	0.32366	27	73	57	29	87	108
  rs6040668	Imputed	C	ADD	381	1.419	0.1495	1.058	1.902	2.339	0.01935	0.09512	0.35696	0.40446	0.32366	27	73	57	29	87	108
  rs6040668	Imputed	C	GEN	381					6.102	0.04731	0.09512	0.35696	0.40446	0.32366	27	73	57	29	87	108
  rs6053005	Imputed	C	DOM	283	0.3707	0.3223	0.1971	0.6972	−3.079	0.00207	0.3237	0.59717	0.52542	0.64848	37	50	31	68	78	19
  rs6054405	Imputed	A	REC	379	1.796	0.3119	0.9747	3.31	1.878	0.0604	0.4419	0.36939	0.38854	0.35586	26	70	61	22	114	86
  rs6054427	Genotyped	G	GEN	383					3.524	0.1717	0.1355	0.39687	0.43082	0.37277	28	81	50	25	117	82
  rs6075186	Imputed	G	DOM	383	0.6821	0.2397	0.4264	1.091	−1.596	0.1105	0.3197	0.15013	0.12579	0.16741	4	32	123	7	61	156
  rs608278	Imputed	A	ADD	345	0.6427	0.1607	0.4691	0.8807	−2.751	0.00594	0.9142	0.48116	0.42414	0.5225	24	75	46	55	99	46
  rs6111540	Imputed	A	ADD	347	0.7778	0.1612	0.5671	1.067	−1.558	0.1191	0.5914	0.48271	0.44178	0.51244	30	69	47	48	110	43
  rs6131206	Imputed	C	ADD	380	1.462	0.1555	1.078	1.983	2.445	0.01449	0.1924	0.31447	0.36306	0.28027	22	70	65	21	83	119
  rs6131208	Imputed	T	ADD	381	1.419	0.1495	1.058	1.902	2.339	0.01935	0.09512	0.35696	0.40446	0.32366	27	73	57	29	87	108
  rs6131208	Imputed	T	GEN	381					6.102	0.04731	0.09512	0.35696	0.40446	0.32366	27	73	57	29	87	108
  rs6131919	Imputed	G	DOM	383	0.6821	0.2397	0.4264	1.091	−1.596	0.1105	0.3197	0.15013	0.12579	0.16741	4	32	123	7	61	156
  rs6134243	Imputed	C	ADD	383	1.429	0.1494	1.066	1.915	2.388	0.01695	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6134243	Imputed	C	GEN	383					6.537	0.03806	0.1203	0.3577	0.40566	0.32366	27	75	57	29	87	108
  rs6136020	Imputed	A	DOM	383	0.6821	0.2397	0.4264	1.091	−1.596	0.1105	0.3197	0.15013	0.12579	0.16741	4	32	123	7	61	156
  rs613799	Imputed	C	DOM	373	1.426	0.2134	0.9386	2.167	1.663	0.0963	0.4587	0.29759	0.32566	0.27828	16	67	69	20	83	118
  rs644041	Imputed	G	ADD	349	1.523	0.1742	1.082	2.142	2.415	0.01575	0.5224	0.29799	0.35	0.26316	16	66	58	12	86	111
  rs644041	Imputed	G	DOM	349	1.58	0.2213	1.024	2.438	2.067	0.03874	0.5224	0.29799	0.35	0.26316	16	66	58	12	86	111
  rs6464377	Imputed	C	DOM	383	1.743	0.2989	0.9701	3.131	1.859	0.06309	1	0.0718	0.08805	0.06027	0	28	131	2	23	199
  rs6474230	Imputed	T	DOM	383	1.832	0.2138	1.205	2.786	2.832	0.00463	0.4624	0.22454	0.28302	0.18304	14	62	83	8	66	150
  rs6476565	Imputed	A	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs6511286	Imputed	T	ADD	382	1.657	0.1628	1.204	2.28	3.103	0.00192	0.9052	0.31021	0.37107	0.26682	22	74	63	14	91	118
  rs6541829	Genotyped	C	REC	383	3.048	0.4236	1.329	6.991	2.631	0.00851	0.7014	0.27415	0.29874	0.2567	18	59	82	9	97	118
  rs6544721	Imputed	G	DOM	383	1.782	0.2114	1.178	2.697	2.733	0.00628	0.7817	0.24413	0.29245	0.20982	12	69	78	12	70	142
  rs6544728	Imputed	T	DOM	377	1.8	0.2171	1.177	2.755	2.709	0.00675	0.7509	0.20424	0.24522	0.175	6	65	86	8	61	151
  rs6565910	Imputed	G	DOM	383	0.6325	0.2139	0.4159	0.9619	−2.141	0.03224	0.3965	0.23629	0.19811	0.26339	5	53	101	13	92	119
  rs6581985	Imputed	G	GEN	383					5.059	0.07972	0.6393	0.32115	0.34277	0.3058	22	65	72	15	107	102
  rs6581985	Imputed	G	REC	383	2.122	0.3548	1.058	4.253	2.12	0.03402	0.6393	0.32115	0.34277	0.3058	22	65	72	15	107	102
  rs6685186	Imputed	T	ADD	383	1.364	0.1533	1.01	1.842	2.026	0.04275	0.9138	0.38251	0.42453	0.35268	27	81	51	28	102	94
  rs6685186	Imputed	T	GEN	383					4.244	0.1198	0.9138	0.38251	0.42453	0.35268	27	81	51	28	102	94
  rs670593	Imputed	A	REC	383	0.6178	0.2944	0.347	1.1	−1.636	0.1018	0.6696	0.39817	0.36478	0.42188	20	76	63	43	103	78
  rs6722640	Imputed	T	DOM	382	0.5778	0.2162	0.3783	0.8827	−2.537	0.01117	0.5916	0.38874	0.35849	0.41031	25	64	70	30	123	70
  rs6746170	Imputed	A	DOM	380	1.811	0.2168	1.184	2.77	2.739	0.00616	0.7506	0.20263	0.24367	0.17342	6	65	87	8	61	153
  rs6757316	Imputed	A	GEN	380					5.94	0.05131	0.535	0.44737	0.49367	0.41441	37	82	39	42	100	80
  rs6805139	Imputed	G	DOM	376	1.64	0.2386	1.028	2.618	2.074	0.03807	0.1787	0.47606	0.51613	0.44796	41	78	36	51	96	74
  rs6808571	Imputed	G	ADD	378	1.439	0.2034	0.9658	2.143	1.789	0.07364	1	0.15741	0.18671	0.13636	6	47	105	3	54	163
  rs6816479	Imputed	A	REC	383	2.214	0.2867	1.262	3.883	2.772	0.00557	0.8315	0.40078	0.45912	0.35938	35	76	48	25	111	88
  rs6865976	Imputed	C	DOM	305	0.5474	0.2612	0.3281	0.9134	−2.307	0.02106	0.646	0.47377	0.42692	0.50857	25	61	44	41	96	38
  rs687047	Imputed	C	ADD	383	0.7104	0.232	0.4509	1.119	−1.474	0.1405	0.8148	0.12272	0.10377	0.13616	2	29	128	4	53	167
  rs6871041	Imputed	G	DOM	367	0.6093	0.2145	0.4002	0.9278	−2.31	0.02092	0.7102	0.29837	0.26144	0.32477	14	52	87	20	99	95
  rs688358	Imputed	A	ADD	382	0.6857	0.2311	0.4359	1.079	−1.632	0.1026	0.4845	0.12304	0.10127	0.13839	2	28	128	5	52	167
  rs6908481	Imputed	C	REC	375	1.848	0.262	1.106	3.088	2.344	0.01908	0.7545	0.45333	0.46452	0.44545	40	64	51	35	126	59
  rs6917224	Imputed	A	ADD	382	1.351	0.1419	1.023	1.784	2.118	0.0342	0.02099	0.42408	0.47152	0.39063	43	63	52	37	101	86
  rs6917224	Imputed	A	GEN	382					6.409	0.04058	0.02099	0.42408	0.47152	0.39063	43	63	52	37	101	86
  rs6920677	Imputed	G	DOM	380	0.5128	0.2196	0.3335	0.7886	−3.041	0.00235	0.5212	0.39868	0.31847	0.45516	12	76	69	45	113	65
  rs6994498	Imputed	G	DOM	383	1.832	0.2138	1.205	2.786	2.832	0.00463	0.4624	0.22454	0.28302	0.18304	14	62	83	8	66	150
  rs6998772	Imputed	T	DOM	383	2.739	0.4524	1.128	6.647	2.227	0.02596	0.00643	0.03394	0.05031	0.02232	1	14	144	2	6	216
  rs7022281	Imputed	C	ADD	382	0.7264	0.1589	0.532	0.9919	−2.011	0.04432	0.1999	0.39791	0.35849	0.42601	18	78	63	36	118	69
  rs7022281	Imputed	C	GEN	382					4.073	0.1305	0.1999	0.39791	0.35849	0.42601	18	78	63	36	118	69
  rs7022281	Imputed	C	REC	382	0.6555	0.3107	0.3565	1.205	−1.359	0.174	0.1999	0.39791	0.35849	0.42601	18	78	63	36	118	69
  rs7043983	Imputed	T	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs7077799	Imputed	A	DOM	382	1.355	0.2098	0.8985	2.045	1.45	0.1471	0.4624	0.2945	0.31761	0.27803	16	69	74	20	84	119
  rs7088947	Imputed	A	ADD	383	0.3545	0.3478	0.1793	0.7009	−2.982	0.00287	0.2394	0.06919	0.03774	0.09152	0	12	147	0	41	183
  rs7089661	Imputed	C	DOM	382	1.351	0.2099	0.8952	2.038	1.432	0.152	0.4588	0.29319	0.31646	0.27679	16	68	74	20	84	120
  rs7102072	Imputed	A	DOM	381	0.6088	0.2112	0.4024	0.9209	−2.35	0.01876	0.902	0.29265	0.25316	0.32063	12	56	90	21	101	101
  rs710832	Genotyped	A	REC	383	0.2657	0.5623	0.08825	0.7997	−2.357	0.0184	0.5936	0.25849	0.24214	0.27009	4	69	86	19	83	122
  rs712531	Imputed	A	DOM	371	1.787	0.2215	1.158	2.759	2.622	0.00874	0.0548	0.35445	0.40323	0.31944	19	87	49	19	100	97
  rs7129817	Imputed	T	ADD	383	0.6903	0.1578	0.5066	0.9405	−2.348	0.01886	0.6497	0.34204	0.2956	0.375	15	64	80	32	104	88
  rs7134262	Imputed	T	GEN	383					3.342	0.1881	0.3841	0.37728	0.40252	0.35938	27	74	58	23	115	86
  rs7134262	Imputed	T	REC	383	1.737	0.3064	0.9527	3.167	1.802	0.07156	0.3841	0.37728	0.40252	0.35938	27	74	58	23	115	86
  rs7138300	Imputed	C	ADD	383	0.7632	0.1542	0.5641	1.032	−1.753	0.07966	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs7138300	Imputed	C	DOM	383	0.5772	0.2224	0.3733	0.8926	−2.471	0.01349	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs722927	Imputed	G	ADD	383	0.4322	0.319	0.2313	0.8077	−2.63	0.00855	0.7112	0.07572	0.04717	0.09598	0	15	144	1	41	182
  rs722927	Imputed	G	DOM	383	0.433	0.3231	0.2299	0.8157	−2.59	0.00958	0.7112	0.07572	0.04717	0.09598	0	15	144	1	41	182
  rs726424	Genotyped	G	ADD	383	0.7473	0.1542	0.5524	1.011	−1.889	0.05889	0.9144	0.38903	0.34906	0.41741	21	69	69	36	115	73
  rs726424	Genotyped	G	GEN	383					4.55	0.1028	0.9144	0.38903	0.34906	0.41741	21	69	69	36	115	73
  rs7295817	Imputed	C	ADD	381	0.7394	0.1533	0.5475	0.9985	−1.97	0.04885	0.9158	0.40551	0.36306	0.43527	22	70	65	40	115	69
  rs7295817	Imputed	C	GEN	381					4.446	0.1083	0.9158	0.40551	0.36306	0.43527	22	70	65	40	115	69
  rs7295817	Imputed	C	REC	381	0.747	0.2896	0.4235	1.318	−1.007	0.3139	0.9158	0.40551	0.36306	0.43527	22	70	65	40	115	69
  rs7297372	Imputed	A	ADD	338	0.7506	0.1757	0.532	1.059	−1.633	0.1025	0.00146	0.53846	0.50368	0.56188	29	79	28	54	119	29
  rs7297372	Imputed	A	GEN	338					2.895	0.2351	0.00146	0.53846	0.50368	0.56188	29	79	28	54	119	29
  rs7298255	Imputed	A	ADD	382	0.7489	0.1551	0.5526	1.015	−1.864	0.06235	0.5292	0.41623	0.37342	0.44643	25	68	65	38	124	62
  rs7298255	Imputed	A	DOM	382	0.571	0.2227	0.3691	0.8835	−2.516	0.01186	0.5292	0.41623	0.37342	0.44643	25	68	65	38	124	62
  rs7305832	Imputed	C	GEN	383					3.342	0.1881	0.3841	0.37728	0.40252	0.35938	27	74	58	23	115	86
  rs7305832	Imputed	C	REC	383	1.737	0.3064	0.9527	3.167	1.802	0.07156	0.3841	0.37728	0.40252	0.35938	27	74	58	23	115	86
  rs737542	Imputed	A	REC	381	3.431	0.4396	1.45	8.122	2.804	0.00504	0.6064	0.27297	0.30063	0.25336	18	59	81	8	97	118
  rs742827	Imputed	A	ADD	361	1.416	0.1525	1.05	1.91	2.282	0.02249	0.1122	0.36704	0.41391	0.33333	27	71	53	29	82	99
  rs742827	Imputed	A	GEN	361					5.995	0.0499	0.1122	0.36704	0.41391	0.33333	27	71	53	29	82	99
  rs7446891	Imputed	G	DOM	373	0.5964	0.2125	0.3932	0.9046	−2.432	0.01503	0.6302	0.31099	0.27419	0.33716	16	53	86	22	103	93
  rs7448641	Imputed	C	ADD	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs7448641	Imputed	C	DOM	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs7460605	Imputed	G	DOM	361	1.533	0.2243	0.988	2.38	1.906	0.05662	0.2254	0.39474	0.42105	0.3756	26	76	50	36	85	88
  rs7468898	Imputed	T	ADD	379	1.539	0.1544	1.137	2.083	2.791	0.00526	0.7518	0.42084	0.48089	0.37838	34	83	40	31	106	85
  rs7468898	Imputed	T	GEN	379					7.907	0.01919	0.7518	0.42084	0.48089	0.37838	34	83	40	31	106	85
  rs7501186	Imputed	A	DOM	383	1.277	0.2476	0.7859	2.074	0.9866	0.3238	0.8082	0.1201	0.13836	0.10714	4	36	119	2	44	178
  rs755117	Imputed	A	DOM	375	1.758	0.223	1.135	2.722	2.53	0.01142	0.8628	0.18267	0.22436	0.15297	7	56	93	6	55	158
  rs7557560	Imputed	T	GEN	383					10.8	0.00451	0.08079	0.20104	0.24528	0.16964	17	44	98	4	68	152
  rs7557560	Imputed	T	REC	383	6.446	0.567	2.122	19.58	3.286	0.00102	0.08079	0.20104	0.24528	0.16964	17	44	98	4	68	152
  rs7562462	Imputed	T	DOM	380	1.588	0.2435	0.9851	2.559	1.898	0.05765	0.2578	0.46974	0.50316	0.44595	35	89	34	43	112	67
  rs757173	Genotyped	G	DOM	383	0.683	0.2133	0.4496	1.038	−1.787	0.0739	0.8284	0.3812	0.34906	0.40402	22	67	70	35	111	78
  rs7607447	Imputed	T	REC	332	1.964	0.3733	0.9451	4.083	1.809	0.0705	0.8998	0.31928	0.34173	0.30311	19	57	63	14	89	90
  rs7639053	Imputed	A	ADD	383	1.6	0.1803	1.124	2.278	2.608	0.00912	0.3899	0.22977	0.27673	0.19643	11	66	82	6	76	142
  rs7648163	Imputed	C	REC	358	2.989	0.3458	1.518	5.886	3.166	0.00154	0.816	0.34916	0.39333	0.31731	27	64	59	15	102	91
  rs7651273	Imputed	A	GEN	383					3.158	0.2061	0.4152	0.19452	0.21384	0.1808	11	46	102	6	69	149
  rs7653190	Imputed	C	ADD	382	1.616	0.1806	1.134	2.302	2.658	0.00786	0.3892	0.23037	0.27848	0.19643	11	66	81	6	76	142
  rs7653685	Genotyped	C	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.758	0.09269	0.12893	0.06696	0	41	118	2	26	196
  rs7684899	Imputed	C	DOM	383	0.6667	0.216	0.4366	1.018	−1.877	0.06051	0.7691	0.22324	0.20126	0.23884	10	44	105	10	87	127
  rs7701604	Imputed	G	ADD	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs7701604	Imputed	G	DOM	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs7703676	Imputed	C	ADD	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs7703676	Imputed	C	DOM	383	0.235	0.778	0.05116	1.08	−1.861	0.0627	1	0.01697	0.00629	0.02455	0	2	157	0	11	213
  rs7711358	Imputed	A	DOM	383	0.6113	0.2097	0.4053	0.9221	−2.347	0.01893	0.4104	0.31723	0.28302	0.34152	18	54	87	24	105	95
  rs7713251	Imputed	C	REC	367	2.559	0.3384	1.319	4.968	2.777	0.00548	0.7295	0.34605	0.38816	0.31628	26	66	60	16	104	95
  rs7737608	Imputed	G	DOM	382	1.5	0.2234	0.9683	2.324	1.816	0.06938	0.6005	0.41754	0.4462	0.39732	29	83	46	40	98	86
  rs7755903	Imputed	A	GEN	382					9.733	0.0077	1	0.42539	0.36478	0.46861	17	82	60	52	105	66
  rs7762993	Imputed	A	ADD	378	1.373	0.1976	0.9323	2.023	1.605	0.1084	0.2987	0.18122	0.20701	0.1629	3	59	95	6	60	155
  rs7762993	Imputed	A	DOM	378	1.537	0.2206	0.9974	2.368	1.948	0.0514	0.2987	0.18122	0.20701	0.1629	3	59	95	6	60	155
  rs7767265	Imputed	G	DOM	382	1.53	0.2141	1.005	2.327	1.985	0.04716	0.453	0.21859	0.24843	0.19731	9	61	89	12	64	147
  rs7769415	Imputed	C	GEN	376					3.721	0.1556	0.9073	0.32846	0.34295	0.31818	22	63	71	19	102	99
  rs7771264	Imputed	T	DOM	383	0.5507	0.2147	0.3616	0.8388	−2.779	0.00546	0.3404	0.25065	0.21384	0.27679	9	50	100	11	102	111
  rs7795792	Imputed	T	REC	383	0.4161	0.2795	0.2406	0.7196	−3.137	0.00171	0.6078	0.46867	0.39937	0.51786	21	85	53	60	112	52
  rs7806481	Imputed	G	REC	383	0.628	0.2629	0.3751	1.051	−1.77	0.0768	0.47	0.4517	0.43082	0.46652	27	83	49	55	99	70
  rs7808536	Imputed	G	DOM	383	1.952	0.2193	1.27	3	3.05	0.00229	1	0.19191	0.23899	0.15848	7	62	90	7	57	160
  rs7814819	Imputed	G	ADD	225	1.743	0.3691	0.8454	3.593	1.505	0.1324	1	0.07333	0.09551	0.05882	0	17	72	1	14	121
  rs7814819	Imputed	G	DOM	225	1.939	0.386	0.9098	4.131	1.715	0.08632	1	0.07333	0.09551	0.05882	0	17	72	1	14	121
  rs7815952	Imputed	T	DOM	383	2.739	0.4524	1.128	6.647	2.227	0.02596	0.00643	0.03394	0.05031	0.02232	1	14	144	2	6	216
  rs7834090	Imputed	T	DOM	383	2.739	0.4524	1.128	6.647	2.227	0.02596	0.00643	0.03394	0.05031	0.02232	1	14	144	2	6	216
  rs7859250	Imputed	C	DOM	383	0.4711	0.3006	0.2614	0.8493	−2.503	0.0123	0.2271	0.09138	0.06289	0.11161	2	16	141	3	44	177
  rs7863577	Genotyped	A	ADD	383	0.5916	0.2865	0.3374	1.037	−1.832	0.06689	0.7318	0.08225	0.05975	0.09821	1	17	141	2	40	182
  rs7863577	Genotyped	A	DOM	383	0.5571	0.3041	0.307	1.011	−1.924	0.0544	0.7318	0.08225	0.05975	0.09821	1	17	141	2	40	182
  rs7902140	Imputed	C	ADD	378	0.622	0.2115	0.4109	0.9414	−2.245	0.02475	0.5866	0.16931	0.13226	0.19507	3	35	117	6	75	142
  rs7921834	Imputed	C	DOM	382	1.351	0.2099	0.8952	2.038	1.432	0.152	0.4588	0.29319	0.31646	0.27679	16	68	74	20	84	120
  rs7939893	Imputed	C	ADD	382	0.8314	0.1592	0.6085	1.136	−1.16	0.2462	0.4351	0.3534	0.33333	0.36771	20	66	73	24	116	83
  rs7939893	Imputed	C	DOM	382	0.6782	0.2127	0.447	1.029	−1.826	0.0679	0.4351	0.3534	0.33333	0.36771	20	66	73	24	116	83
  rs7955901	Imputed	C	ADD	383	0.7632	0.1542	0.5641	1.032	−1.753	0.07966	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs7955901	Imputed	C	DOM	383	0.5772	0.2224	0.3733	0.8926	−2.471	0.01349	0.6	0.41775	0.37736	0.44643	26	68	65	38	124	62
  rs7956274	Imputed	T	ADD	382	0.7489	0.1551	0.5526	1.015	−1.864	0.06235	0.5292	0.41623	0.37342	0.44643	25	68	65	38	124	62
  rs7956274	Imputed	T	DOM	382	0.571	0.2227	0.3691	0.8835	−2.516	0.01186	0.5292	0.41623	0.37342	0.44643	25	68	65	38	124	62
  rs7957932	Imputed	G	ADD	380	0.7622	0.1541	0.5635	1.031	−1.762	0.07806	0.6008	0.42895	0.38854	0.4574	27	68	62	40	124	59
  rs7957932	Imputed	G	DOM	380	0.5724	0.2251	0.3682	0.8898	−2.479	0.01319	0.6008	0.42895	0.38854	0.4574	27	68	62	40	124	59
  rs7984294	Imputed	A	DOM	341	1.992	0.4122	0.888	4.468	1.672	0.09458	1	0.03959	0.05594	0.02778	0	16	127	0	11	187
  rs7994286	Imputed	A	ADD	377	0.5714	0.2665	0.3389	0.9633	−2.1	0.03571	0.7705	0.09814	0.07006	0.11818	1	20	136	3	46	171
  rs7994286	Imputed	A	DOM	377	0.5491	0.2859	0.3135	0.9616	−2.097	0.03601	0.7705	0.09814	0.07006	0.11818	1	20	136	3	46	171
  rs8038229	Genotyped	A	ADD	383	0.6055	0.165	0.4381	0.8367	−3.04	0.00237	0.3986	0.30418	0.24528	0.34598	11	56	92	28	99	97
  rs8038229	Genotyped	A	DOM	383	0.534	0.2122	0.3523	0.8093	−2.957	0.0031	0.3986	0.30418	0.24528	0.34598	11	56	92	28	99	97
  rs8043336	Imputed	C	GEN	370					8.202	0.01656	0.3028	0.34865	0.2987	0.38426	9	74	71	31	104	81
  rs8043336	Imputed	C	REC	370	0.3477	0.3977	0.1595	0.758	−2.657	0.00789	0.3028	0.34865	0.2987	0.38426	9	74	71	31	104	81
  rs8054431	Imputed	T	DOM	372	2.022	0.2234	1.305	3.133	3.153	0.00162	0.3127	0.3629	0.42308	0.31944	22	88	46	22	94	100
  rs8066502	Imputed	T	DOM	383	0.6823	0.229	0.4356	1.069	−1.669	0.09506	0.8575	0.17232	0.15094	0.1875	6	36	117	6	72	146
  rs8068714	Imputed	T	DOM	383	0.7037	0.2279	0.4502	1.1	−1.542	0.1231	0.8589	0.17363	0.15409	0.1875	6	37	116	6	72	146
  rs892575	Imputed	T	ADD	383	1.417	0.1666	1.022	1.964	2.092	0.03642	0.4618	0.29634	0.33333	0.27009	17	72	70	13	95	116
  rs892583	Imputed	G	ADD	383	1.437	0.1677	1.034	1.996	2.162	0.03065	0.3893	0.29243	0.33019	0.26563	17	71	71	12	95	117
  rs915494	Imputed	A	ADD	374	1.204	0.1605	0.8791	1.649	1.157	0.2474	0.3776	0.28877	0.31046	0.27376	16	63	74	19	83	119
  rs915494	Imputed	A	DOM	374	1.279	0.2121	0.8439	1.938	1.16	0.2462	0.3776	0.28877	0.31046	0.27376	16	63	74	19	83	119
  rs917295	Imputed	G	DOM	383	0.6021	0.2099	0.3991	0.9085	−2.417	0.01564	0.7244	0.31984	0.28302	0.34598	17	56	86	24	107	93
  rs922594	Imputed	T	DOM	375	0.5825	0.2147	0.3824	0.8872	−2.518	0.01181	0.4237	0.34133	0.3	0.37045	15	63	77	25	113	82
  rs9301653	Imputed	T	ADD	383	0.5758	0.2661	0.3418	0.97	−2.074	0.03805	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs9301653	Imputed	T	DOM	383	0.554	0.2856	0.3166	0.9696	−2.068	0.03864	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs9309988	Imputed	G	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.758	0.09269	0.12893	0.06696	0	41	118	2	26	196
  rs9309989	Genotyped	C	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.758	0.09269	0.12893	0.06696	0	41	118	2	26	196
  rs9310221	Imputed	A	DOM	352	1.531	0.2314	0.9727	2.41	1.84	0.06574	0.7387	0.39915	0.40972	0.39183	17	84	43	37	89	82
  rs9327555	Imputed	T	DOM	383	0.6021	0.2099	0.3991	0.9085	−2.417	0.01564	0.7244	0.31984	0.28302	0.34598	17	56	86	24	107	93
  rs937890	Imputed	G	DOM	383	0.7037	0.2279	0.4502	1.1	−1.542	0.1231	0.8589	0.17363	0.15409	0.1875	6	37	116	6	72	146
  rs9454967	Imputed	G	ADD	382	2.387	0.3056	1.311	4.345	2.847	0.00442	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs9454967	Imputed	G	DOM	382	2.904	0.3322	1.514	5.569	3.209	0.00133	0.1765	0.06283	0.09494	0.04018	1	28	129	2	14	208
  rs9471295	Imputed	T	DOM	383	1.488	0.2326	0.9435	2.348	1.71	0.08731	0.5442	0.14883	0.16667	0.13616	2	49	108	8	45	171
  rs9477007	Imputed	A	ADD	380	1.357	0.1432	1.025	1.797	2.132	0.03298	0.04681	0.42763	0.47484	0.39367	42	67	50	37	100	84
  rs9477007	Imputed	A	GEN	380					5.531	0.06295	0.04681	0.42763	0.47484	0.39367	42	67	50	37	100	84
  rs9487279	Imputed	T	DOM	366	0.5667	0.2254	0.3643	0.8814	−2.52	0.01173	0.1024	0.40164	0.33882	0.44626	13	77	62	38	115	61
  rs949016	Imputed	C	ADD	383	1.437	0.1677	1.034	1.996	2.162	0.03065	0.3893	0.29243	0.33019	0.26563	17	71	71	12	95	117
  rs9555973	Imputed	G	ADD	379	0.5702	0.2704	0.3356	0.9686	−2.078	0.03773	0.7618	0.09499	0.06731	0.11435	1	19	136	3	45	175
  rs9555973	Imputed	G	DOM	379	0.5463	0.2905	0.3091	0.9655	−2.081	0.03744	0.7618	0.09499	0.06731	0.11435	1	19	136	3	45	175
  rs9557510	Imputed	G	ADD	383	1.582	0.1986	1.072	2.334	2.308	0.02098	0.2295	0.15144	0.18868	0.125	6	48	105	6	44	174
  rs9557510	Imputed	G	DOM	383	1.775	0.2327	1.125	2.801	2.466	0.01365	0.2295	0.15144	0.18868	0.125	6	48	105	6	44	174
  rs9560584	Imputed	T	DOM	382	0.5572	0.2856	0.3184	0.9752	−2.048	0.04058	0.7684	0.09686	0.06962	0.11607	1	20	137	3	46	175
  rs9588770	Imputed	T	DOM	381	0.497	0.2943	0.2792	0.8849	−2.376	0.01752	0.7612	0.09449	0.06329	0.11659	1	18	139	3	46	174
  rs9588848	Imputed	C	ADD	383	0.5758	0.2661	0.3418	0.97	−2.074	0.03805	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs9588848	Imputed	C	DOM	383	0.554	0.2856	0.3166	0.9696	−2.068	0.03864	0.7681	0.09661	0.06918	0.11607	1	20	138	3	46	175
  rs966583	Imputed	A	ADD	382	0.7239	0.1599	0.5291	0.9903	−2.021	0.04332	0.1993	0.39398	0.34906	0.42601	19	73	67	34	122	67
  rs966583	Imputed	A	DOM	382	0.6175	0.2202	0.4011	0.9507	−2.189	0.02856	0.1993	0.39398	0.34906	0.42601	19	73	67	34	122	67
  rs974130	Genotyped	A	REC	383	2.214	0.2867	1.262	3.883	2.772	0.00557	0.8315	0.40078	0.45912	0.35938	35	76	48	25	111	88
  rs977160	Imputed	T	ADD	382	1.378	0.1666	0.9945	1.911	1.927	0.05403	0.7069	0.28403	0.31761	0.26009	17	67	75	12	92	119
  rs9812206	Imputed	G	ADD	383	0.3883	0.2849	0.2221	0.6787	−3.321	0.0009	0.7825	0.10183	0.05975	0.1317	0	19	140	3	53	168
  rs9812206	Imputed	G	DOM	383	0.3876	0.2917	0.2188	0.6867	−3.248	0.00116	0.7825	0.10183	0.05975	0.1317	0	19	140	3	53	168
  rs9813552	Imputed	G	ADD	379	0.3826	0.2913	0.2162	0.6772	−3.298	0.00097	1	0.09894	0.05732	0.12838	0	18	139	3	51	168
  rs9813552	Imputed	G	DOM	379	0.3816	0.2983	0.2127	0.6847	−3.23	0.00124	1	0.09894	0.05732	0.12838	0	18	139	3	51	168
  rs9815037	Imputed	T	ADD	382	0.3819	0.2906	0.2161	0.675	−3.313	0.00092	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9815037	Imputed	T	DOM	382	0.3809	0.2976	0.2125	0.6825	−3.243	0.00118	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9825349	Imputed	A	ADD	382	0.3819	0.2906	0.2161	0.675	−3.313	0.00092	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9825349	Imputed	A	DOM	382	0.3809	0.2976	0.2125	0.6825	−3.243	0.00118	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9834217	Imputed	T	ADD	382	0.3819	0.2906	0.2161	0.675	−3.313	0.00092	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9834217	Imputed	T	DOM	382	0.3809	0.2976	0.2125	0.6825	−3.243	0.00118	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9840460	Imputed	T	ADD	382	0.3819	0.2906	0.2161	0.675	−3.313	0.00092	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9840460	Imputed	T	DOM	382	0.3809	0.2976	0.2125	0.6825	−3.243	0.00118	1	0.09817	0.0566	0.1278	0	18	141	3	51	169
  rs9840756	Imputed	A	ADD	380	0.3808	0.291	0.2153	0.6737	−3.317	0.00091	1	0.09868	0.05696	0.12838	0	18	140	3	51	168
  rs9840756	Imputed	A	DOM	380	0.3798	0.298	0.2118	0.681	−3.249	0.00116	1	0.09868	0.05696	0.12838	0	18	140	3	51	168
  rs9844801	Imputed	C	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.3464	0.09138	0.12893	0.06473	0	41	118	1	27	196
  rs985375	Imputed	A	GEN	374					5.977	0.05036	0.5979	0.26471	0.30844	0.23409	15	65	74	9	85	126
  rs9869187	Imputed	C	ADD	383	0.4258	0.2859	0.2431	0.7458	−2.986	0.00283	1	0.09661	0.05975	0.12277	0	19	140	3	49	172
  rs9869187	Imputed	C	DOM	383	0.4271	0.294	0.24	0.7599	−2.894	0.0038	1	0.09661	0.05975	0.12277	0	19	140	3	49	172
  rs9872327	Imputed	T	DOM	383	2.42	0.2725	1.419	4.128	3.244	0.00118	0.3464	0.09138	0.12893	0.06473	0	41	118	1	27	196
  rs9881685	Imputed	A	ADD	379	0.377	0.2935	0.2121	0.6701	−3.324	0.00089	0.5599	0.09894	0.05769	0.1278	0	18	138	2	53	168
  rs9881685	Imputed	A	DOM	379	0.3761	0.298	0.2098	0.6745	−3.282	0.00103	0.5599	0.09894	0.05769	0.1278	0	18	138	2	53	168
  rs9909499	Imputed	C	DOM	362	1.559	0.2159	1.021	2.381	2.058	0.03962	0.08453	0.2721	0.29801	0.25355	7	76	68	13	81	117
  rs9911847	Imputed	G	DOM	382	0.6877	0.2291	0.4389	1.078	−1.634	0.1023	0.8576	0.17277	0.1519	0.1875	6	36	116	6	72	146
  rs9946886	Imputed	G	REC	156	0.3262	0.5121	0.1196	0.8902	−2.187	0.02873	0.3882	0.36218	0.29452	0.42169	6	31	36	17	36	30
  rs9958823	Imputed	A	ADD	377	1.444	0.1687	1.038	2.01	2.179	0.02933	0.3868	0.29576	0.33439	0.26818	17	71	69	12	94	114
  rs9965248	Imputed	T	ADD	379	1.399	0.167	1.009	1.941	2.011	0.04433	0.537	0.29551	0.33121	0.27027	17	70	70	13	94	115

• TABLE 11
  													ATOR-	PRA-	ATOR-		ATOR-	PRA-		PRA-
  													VA_	VA_	VA_	ATOR-	VA_	VA_	PRA-	VA_
  		ALL-									HW_	ALL-	ALL-	ALL-	A1_	VA_	A2_	A1_	VA_	A2_
  		ELE	MOD-	N-							PVA	ELE_	ELE_	ELE_	HZ_	HET_	HZ	HZ_	HET_	HZ_
  SNP rs #	SOURCE	(A1)	EL	MISS	OR	SE	L95	U95	STAT	P	LUE	FREQ	FREQ	FREQ	COUNT	COUNT	COUNT	COUNT	COUNT	COUNT

  rs198460	Genotyped	G	REC	443	1.956	0.2218	1.267	3.021	3.026	0.00248	1	0.51129	0.56021	0.47421	64	86	41	52	135	65
  rs603940	Genotyped	G	REC	443	0.3862	0.3119	0.2095	0.7117	−3.05	0.00229	0.9214	0.39955	0.37958	0.41468	19	107	65	51	107	94
  rs10021016	Genotyped	G	GEN	443					6.477	0.03922	0.7144	0.26298	0.29843	0.23611	20	74	97	12	95	145
  rs1003148	Imputed	C	ADD	427	0.7405	0.1452	0.5572	0.9843	−2.069	0.03853	0.9214	0.42974	0.38798	0.46107	23	96	64	55	115	74
  rs1003148	Imputed	C	GEN	427					6.652	0.03594	0.9214	0.42974	0.38798	0.46107	23	96	64	55	115	74
  rs1003148	Imputed	C	REC	427	0.4879	0.2786	0.2826	0.8423	−2.576	0.01	0.9214	0.42974	0.38798	0.46107	23	96	64	55	115	74
  rs10046799	Imputed	C	ADD	440	0.7946	0.1374	0.607	1.04	−1.672	0.09444	0.4976	0.5625	0.5291	0.58765	61	78	50	82	131	38
  rs10046799	Imputed	C	GEN	440					9.736	0.00769	0.4976	0.5625	0.5291	0.58765	61	78	50	82	131	38
  rs10051148	Imputed	C	DOM	443	0.6399	0.1948	0.4368	0.9373	−2.293	0.02187	0.8242	0.30813	0.2801	0.32937	20	67	104	23	120	109
  rs10054055	Imputed	T	DOM	440	0.5872	0.2006	0.3963	0.8702	−2.653	0.00797	0.3313	0.32841	0.29365	0.35458	23	65	101	29	120	102
  rs10067895	Imputed	A	DOM	440	0.577	0.2025	0.388	0.8581	−2.716	0.00661	0.07522	0.34886	0.31316	0.376	27	65	98	35	118	97
  rs1008705	Imputed	C	DOM	353	2.01	0.2249	1.294	3.124	3.106	0.0019	0.6981	0.28895	0.32667	0.26108	11	76	63	20	66	117
  rs10105871	Imputed	C	DOM	382	1.492	0.219	0.9712	2.291	1.827	0.06776	0.1311	0.38351	0.41212	0.36175	22	92	51	27	103	87
  rs10116807	Imputed	A	GEN	436					7.758	0.02068	0.8866	0.21216	0.25263	0.18089	13	70	107	7	75	164
  rs10116807	Imputed	A	REC	436	2.869	0.4949	1.087	7.568	2.129	0.03322	0.8866	0.21216	0.25263	0.18089	13	70	107	7	75	164
  rs10121941	Imputed	C	DOM	443	1.177	0.2597	0.7077	1.959	6.29E−01	0.5296	0.5598	0.08691	0.09424	0.08135	2	32	157	2	37	213
  rs10128638	Genotyped	G	DOM	443	0.6667	0.2297	0.425	1.046	−1.765	0.07748	1	0.52483	0.49738	0.54563	50	90	51	72	131	49
  rs1012924	Imputed	G	ADD	438	1.725	0.2225	1.115	2.668	2.451	0.01426	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs1012924	Imputed	G	DOM	438	1.754	0.2318	1.113	2.762	2.423	0.01539	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs1016030	Genotyped	G	ADD	442	1.159	0.1474	0.8678	1.547	0.9985	0.318	1	0.36425	0.3822	0.3506	27	92	72	31	114	106
  rs1016030	Genotyped	G	GEN	442					1.088	0.5805	1	0.36425	0.3822	0.3506	27	92	72	31	114	106
  rs1017558	Imputed	A	REC	430	0.7905	0.293	0.4452	1.404	−0.8024	0.4223	0.3984	0.35349	0.32787	0.37247	22	76	85	36	112	99
  rs10183431	Imputed	T	DOM	438	1.231	0.1969	0.8366	1.81	1.054	0.292	0.4508	0.25342	0.26064	0.248	11	76	101	20	84	146
  rs10195401	Imputed	C	DOM	440	1.047	0.206	0.6991	1.568	0.2228	0.8237	0.112	0.4	0.40263	0.398	27	99	64	35	129	86
  rs10239416	Imputed	A	DOM	431	1.361	0.2052	0.9105	2.035	1.503	0.1328	0.8386	0.38399	0.41444	0.36066	31	93	63	31	114	99
  rs1032188	Imputed	G	GEN	443					6.472	0.03932	0.5638	0.29007	0.27225	0.30357	10	84	97	30	93	129
  rs1032188	Imputed	G	REC	443	0.3936	0.3872	0.1843	0.8406	−2.408	0.01603	0.5638	0.29007	0.27225	0.30357	10	84	97	30	93	129
  rs10468988	Imputed	G	ADD	438	1.083	0.1637	0.7858	1.493	0.4879	0.6256	0.7885	0.23174	0.23947	0.22581	9	73	108	13	86	149
  rs10478919	Imputed	G	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs10506623	Imputed	C	DOM	442	0.7185	0.204	0.4817	1.072	−1.621	0.1051	0.6908	0.3948	0.36316	0.41865	26	86	78	45	121	86
  rs10506626	Imputed	A	DOM	443	0.6807	0.2015	0.4586	1.01	−1.909	0.05621	0.5504	0.39391	0.35602	0.42262	26	84	81	46	121	85
  rs10509477	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131	0.1655	0.33409	0.36911	0.30754	29	83	79	27	101	124
  rs10511071	Imputed	C	DOM	443	0.8286	0.2404	0.5173	1.327	−0.7821	0.4342	0.8039	0.10722	0.09686	0.11508	1	35	155	3	52	197
  rs10511072	Imputed	G	DOM	443	0.8286	0.2404	0.5173	1.327	−0.7821	0.4342	0.8039	0.10722	0.09686	0.11508	1	35	155	3	52	197
  rs10511199	Imputed	C	ADD	442	1.021	0.1625	0.7424	1.404	0.1273	0.8987	0.8924	0.22624	0.22895	0.22421	10	67	113	13	87	152
  rs10513283	Imputed	G	GEN	442					1.393	0.4984	0.6226	0.17534	0.19211	0.1627	7	59	124	8	66	178
  rs10520072	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs1065639	Imputed	C	DOM	209	2.955	1.237	0.2613	33.41	0.8755	0.3813	1	0.00718	0.01111	0.0042	0	2	88	0	1	118
  rs10733846	Imputed	G	ADD	435	0.8325	0.1945	0.5686	1.219	−0.9428	0.3458	0.4814	0.16207	0.14706	0.17339	5	45	137	4	78	166
  rs10733846	Imputed	G	DOM	435	0.7557	0.2153	0.4955	1.152	−1.301	0.1933	0.4814	0.16207	0.14706	0.17339	5	45	137	4	78	166
  rs10737390	Imputed	T	DOM	418	1.128	0.213	0.7431	1.712	0.5659	0.5715	0.3626	0.40909	0.41899	0.40167	30	90	59	35	122	82
  rs10749293	Imputed	G	DOM	441	1.442	0.1947	0.9847	2.113	1.881	0.05998	0.1901	0.322	0.35789	0.29482	26	84	80	26	96	129
  rs10752159	Imputed	G	DOM	442	1.434	0.2005	0.968	2.124	1.798	0.07223	0.5658	0.20814	0.22513	0.19522	7	72	112	14	70	167
  rs10753760	Imputed	T	ADD	423	0.9252	0.1361	0.7085	1.208	−0.5713	0.5678	0.01675	0.41844	0.41081	0.42437	36	80	69	50	102	86
  rs10753760	Imputed	T	GEN	423					0.3766	0.8284	0.01675	0.41844	0.41081	0.42437	36	80	69	50	102	86
  rs10757887	Imputed	C	DOM	443	1.073	0.1955	0.7315	1.574	0.3608	0.7182	0.05609	0.2754	0.28272	0.26984	19	70	102	23	90	139
  rs10758326	Imputed	A	ADD	440	0.6884	0.1481	0.515	0.9203	−2.521	0.01172	0.5467	0.38523	0.34211	0.418	16	98	76	46	117	87
  rs10758326	Imputed	A	GEN	440					9.42	0.009	0.5467	0.38523	0.34211	0.418	16	98	76	46	117	87
  rs10758326	Imputed	A	REC	440	0.3854	0.3129	0.2087	0.7116	−3.047	0.00231	0.5467	0.38523	0.34211	0.418	16	98	76	46	117	87
  rs10762236	Genotyped	G	ADD	443	0.93	0.1858	0.6461	1.339	−0.3906	0.6961	0.5219	0.18172	0.17539	0.18651	7	53	131	5	84	163
  rs10765769	Imputed	C	ADD	441	1.226	0.1457	0.9215	1.631	1.399	0.1618	0.8413	0.38776	0.4127	0.36905	31	94	64	34	118	100
  rs10765769	Imputed	C	GEN	441					2.026	0.3632	0.8413	0.38776	0.4127	0.36905	31	94	64	34	118	100
  rs10784891	Imputed	C	ADD	422	0.7472	0.1404	0.5675	0.9839	−2.076	0.03794	0.4305	0.4455	0.40489	0.47689	30	89	65	58	111	69
  rs10784891	Imputed	C	DOM	422	0.7374	0.2125	0.4862	1.118	−1.433	0.1518	0.4305	0.4455	0.40489	0.47689	30	89	65	58	111	69
  rs10787923	Imputed	G	DOM	439	1.448	0.1952	0.9878	2.123	1.897	0.05785	0.1572	0.32232	0.35904	0.29482	26	83	79	26	96	129
  rs10787949	Imputed	A	DOM	442	1.352	0.1976	0.9177	1.991	1.525	0.1272	0.1377	0.33937	0.37173	0.31474	29	84	78	29	100	122
  rs10787951	Imputed	G	DOM	441	1.349	0.1976	0.9157	1.987	1.514	0.1299	0.1364	0.339	0.37105	0.31474	29	83	78	29	100	122
  rs10787983	Imputed	C	DOM	441	1.351	0.1964	0.9194	1.986	1.532	0.1255	0.1642	0.33447	0.36911	0.308	29	83	79	27	100	123
  rs10788380	Imputed	C	ADD	438	1.318	0.1398	1.002	1.733	1.973	0.04851	0.9239	0.49658	0.53723	0.466	51	100	37	56	121	73
  rs10788380	Imputed	C	DOM	438	1.663	0.2322	1.055	2.621	2.191	0.02847	0.9239	0.49658	0.53723	0.466	51	100	37	56	121	73
  rs10788380	Imputed	C	GEN	438					4.897	0.08641	0.9239	0.49658	0.53723	0.466	51	100	37	56	121	73
  rs10814418	Imputed	G	DOM	442	1.184	0.2598	0.7118	1.97	0.6512	0.5149	0.7613	0.0871	0.09474	0.08135	2	32	156	2	37	213
  rs10831417	Imputed	A	ADD	443	1.151	0.1492	0.8595	1.543	0.9453	0.3445	0.6065	0.35779	0.37435	0.34524	25	93	73	29	116	107
  rs10831417	Imputed	A	GEN	443					0.969	0.616	0.6065	0.35779	0.37435	0.34524	25	93	73	29	116	107
  rs10831422	Imputed	C	ADD	441	1.164	0.1481	0.871	1.557	1.028	0.304	0.918	0.36281	0.38095	0.34921	27	90	72	30	116	106
  rs10831422	Imputed	C	GEN	441					1.057	0.5895	0.918	0.36281	0.38095	0.34921	27	90	72	30	116	106
  rs10862931	Imputed	C	GEN	439					6.025	0.04917	0.8337	0.34966	0.38158	0.3253	32	81	77	23	116	110
  rs10865197	Imputed	C	DOM	438	1.231	0.1969	0.8366	1.81	1.054	0.292	0.4508	0.25342	0.26064	0.248	11	76	101	20	84	146
  rs10871302	Imputed	A	DOM	443	2.011	0.2218	1.302	3.107	3.15	0.00163	0.4471	0.14447	0.17801	0.11905	3	62	126	8	44	200
  rs10877463	Imputed	C	DOM	443	0.5826	0.1985	0.3948	0.8597	−2.722	0.0065	0.6802	0.36005	0.31675	0.39286	21	79	91	34	130	88
  rs10877468	Imputed	C	DOM	442	0.5848	0.1985	0.3963	0.8629	−2.703	0.00688	0.6808	0.35973	0.31675	0.39243	21	79	91	34	129	88
  rs10879240	Imputed	C	ADD	428	0.7296	0.1403	0.5542	0.9605	−2.247	0.02462	0.434	0.44743	0.40426	0.48125	30	92	66	60	111	69
  rs10879242	Imputed	A	DOM	421	0.7102	0.2081	0.4724	1.068	−1.644	0.1001	0.9197	0.40855	0.37297	0.43644	26	86	73	45	116	75
  rs10879245	Imputed	G	DOM	421	0.7102	0.2081	0.4724	1.068	−1.644	0.1001	0.9197	0.40855	0.37297	0.43644	26	86	73	45	116	75
  rs10879249	Imputed	T	DOM	440	0.7247	0.2038	0.486	1.081	−1.58	0.1141	0.7662	0.39773	0.36579	0.422	26	87	77	45	121	84
  rs10886452	Imputed	A	DOM	440	1.376	0.1972	0.9349	2.025	1.619	0.1055	0.1648	0.33523	0.37368	0.306	30	82	78	26	101	123
  rs10886463	Imputed	C	DOM	442	1.352	0.1976	0.9177	1.991	1.525	0.1272	0.1118	0.3405	0.37435	0.31474	30	83	78	29	100	122
  rs10886465	Imputed	A	DOM	441	1.355	0.1976	0.9197	1.995	1.536	0.1245	0.1364	0.339	0.37435	0.312	30	83	78	28	100	122
  rs10886526	Imputed	C	DOM	439	1.364	0.197	0.9275	2.007	1.578	0.1146	0.2383	0.33257	0.36772	0.306	28	83	78	26	101	123
  rs10902437	Imputed	G	ADD	393	1.494	0.1583	1.095	2.037	2.534	0.01127	0.6725	0.39186	0.43558	0.36087	34	74	55	24	118	88
  rs10941126	Imputed	G	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs10941126	Imputed	G	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs10947871	Imputed	A	DOM	391	2.143	0.2487	1.316	3.49	3.065	0.00218	1	0.11893	0.15805	0.08756	3	49	122	2	34	181
  rs10972978	Imputed	G	DOM	437	1.24	0.2619	0.7423	2.072	0.8222	0.4109	0.5546	0.08696	0.09626	0.08	2	32	153	2	36	212
  rs10973012	Imputed	A	DOM	443	1.177	0.2597	0.7077	1.959	0.6286	0.5296	0.5598	0.08691	0.09424	0.08135	2	32	157	2	37	213
  rs10974028	Genotyped	G	ADD	443	1.203	0.1904	0.8287	1.748	0.9728	0.3306	0.726	0.16027	0.17277	0.15079	5	56	130	5	66	181
  rs10974028	Genotyped	G	DOM	443	1.224	0.2126	0.807	1.857	0.9516	0.3413	0.726	0.16027	0.17277	0.15079	5	56	130	5	66	181
  rs11021302	Imputed	A	ADD	441	1.164	0.1481	0.871	1.557	1.028	0.304	0.918	0.36281	0.38095	0.34921	27	90	72	30	116	106
  rs11021302	Imputed	A	GEN	441					1.057	0.5895	0.918	0.36281	0.38095	0.34921	27	90	72	30	116	106
  rs11099644	Imputed	G	REC	430	0.7905	0.293	0.4452	1.404	−0.8024	0.4223	0.3984	0.35349	0.32787	0.37247	22	76	85	36	112	99
  rs11138315	Imputed	G	ADD	443	0.5453	0.2248	0.351	0.8473	−2.697	0.00699	0.2265	0.13544	0.10209	0.16071	2	35	154	9	63	180
  rs11149802	Imputed	T	DOM	443	2.011	0.2218	1.302	3.107	3.15	0.00163	0.4471	0.14447	0.17801	0.11905	3	62	126	8	44	200
  rs1116596	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs11178531	Imputed	A	ADD	439	0.7197	0.1371	0.5501	0.9416	−2.399	0.01643	0.3881	0.46811	0.42105	0.50402	34	92	64	67	117	65
  rs11178531	Imputed	A	DOM	439	0.6936	0.2116	0.4581	1.05	−1.729	0.08386	0.3881	0.46811	0.42105	0.50402	34	92	64	67	117	65
  rs11178575	Imputed	C	GEN	441					8.684	0.01301	0.3129	0.30385	0.3534	0.266	22	91	78	14	105	131
  rs11178575	Imputed	C	REC	441	2.252	0.3587	1.115	4.549	2.263	0.02362	0.3129	0.30385	0.3534	0.266	22	91	78	14	105	131
  rs11178577	Imputed	T	GEN	439					8.67	0.0131	0.2621	0.30752	0.35789	0.26908	22	92	76	14	106	129
  rs11178577	Imputed	T	REC	439	2.243	0.3588	1.11	4.532	2.252	0.02435	0.2621	0.30752	0.35789	0.26908	22	92	76	14	106	129
  rs11178583	Imputed	A	DOM	443	0.7338	0.2032	0.4927	1.093	−1.523	0.1277	0.6922	0.39503	0.36387	0.41865	26	87	78	45	121	86
  rs11178589	Imputed	T	DOM	437	0.7215	0.2047	0.4831	1.078	−1.595	0.1108	0.8419	0.39931	0.36579	0.4251	26	87	77	45	120	82
  rs11178594	Imputed	C	DOM	441	0.7044	0.202	0.4741	1.046	−1.735	0.08274	1	0.40249	0.36842	0.42829	26	88	76	45	125	81
  rs11178602	Imputed	T	DOM	439	0.7005	0.2027	0.4709	1.042	−1.757	0.079	1	0.40205	0.36772	0.428	26	87	76	45	124	81
  rs11178648	Imputed	T	DOM	440	0.6786	0.2027	0.4561	1.01	−1.912	0.05581	0.4852	0.39432	0.35714	0.42231	26	83	80	46	120	85
  rs11198877	Imputed	T	DOM	441	1.369	0.1971	0.9302	2.014	1.593	0.1113	0.1996	0.3356	0.37368	0.30677	30	82	78	26	102	123
  rs11198942	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131	0.1655	0.33409	0.36911	0.30754	29	83	79	27	101	124
  rs11221075	Imputed	A	ADD	417	0.4912	0.2448	0.304	0.7936	−2.904	0.00369	1	0.11391	0.07542	0.14286	0	27	152	5	58	175
  rs11242020	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs11242021	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs11242022	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs11242023	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs1149350	Imputed	A	DOM	443	0.8901	0.2092	0.5906	1.341	−0.5566	0.5778	0.01047	0.21445	0.18848	0.23413	6	60	125	24	70	158
  rs1150143	Imputed	G	DOM	435	1.007	0.2015	0.6785	1.495	0.03498	0.9721	0.1573	0.38851	0.38978	0.38755	31	83	72	42	109	98
  rs11576627	Imputed	T	ADD	441	1.439	0.1975	0.977	2.119	1.842	0.06547	0.01289	0.12358	0.15	0.10359	7	43	140	6	40	205
  rs11576627	Imputed	T	DOM	441	1.57	0.2354	0.9899	2.491	1.917	0.05525	0.01289	0.12358	0.15	0.10359	7	43	140	6	40	205
  rs11602189	Imputed	A	DOM	440	0.8739	0.1947	0.5967	1.28	−0.6923	0.4888	0.3294	0.32727	0.31579	0.336	17	86	87	25	118	107
  rs11605163	Imputed	A	DOM	440	1.075	0.249	0.6597	1.751	0.2893	0.7723	0.4443	0.10341	0.11111	0.09761	4	34	151	2	45	204
  rs11615214	Imputed	G	ADD	437	0.7544	0.1432	0.5697	0.9989	−1.968	0.04908	0.9205	0.39359	0.35526	0.42308	18	99	73	49	111	87
  rs11615214	Imputed	G	GEN	437					8.718	0.01279	0.9205	0.39359	0.35526	0.42308	18	99	73	49	111	87
  rs11642394	Imputed	C	DOM	443	2.011	0.2218	1.302	3.107	3.15	0.00163	0.4471	0.14447	0.17801	0.11905	3	62	126	8	44	200
  rs11644943	Imputed	A	ADD	421	1.464	0.1665	1.056	2.029	2.29	0.02202	0.7836	0.22922	0.26776	0.19958	13	72	98	10	75	153
  rs11656608	Imputed	T	DOM	442	0.5127	0.2187	0.334	0.7871	−3.055	0.00225	0.8632	0.16403	0.11842	0.19841	2	41	147	9	82	161
  rs11661309	Imputed	A	ADD	439	0.8005	0.1812	0.5612	1.142	−1.228	0.2194	0.872	0.18109	0.16138	0.196	3	55	131	12	74	164
  rs11661309	Imputed	A	DOM	439	0.8571	0.2089	0.5691	1.291	−0.7383	0.4603	0.872	0.18109	0.16138	0.196	3	55	131	12	74	164
  rs11666131	Imputed	A	ADD	441	1.074	0.1682	0.772	1.493	0.4219	0.6731	0.2245	0.22676	0.23158	0.22311	6	76	108	12	88	151
  rs11743355	Imputed	C	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs11743355	Imputed	C	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs11746806	Imputed	T	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs11746806	Imputed	T	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs11746959	Imputed	T	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs11746959	Imputed	T	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs11749272	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs11901899	Imputed	A	DOM	426	1.452	0.1995	0.9821	2.147	1.869	0.06157	0.3322	0.27582	0.30707	0.25207	14	85	85	14	94	134
  rs11926319	Imputed	G	ADD	443	0.9777	0.2632	0.5837	1.638	−0.08556	0.9318	0.4982	0.07675	0.07592	0.07738	0	29	162	1	37	214
  rs11926319	Imputed	G	DOM	443	1.007	0.269	0.5945	1.706	0.02639	0.9789	0.4982	0.07675	0.07592	0.07738	0	29	162	1	37	214
  rs11956952	Imputed	C	DOM	418	0.6491	0.2055	0.4339	0.971	−2.103	0.03544	1	0.24282	0.21858	0.2617	12	56	115	12	99	124
  rs12025826	Imputed	G	DOM	434	1.459	0.2095	0.9676	2.199	1.803	0.07141	1	0.41705	0.4328	0.40524	29	103	54	46	109	93
  rs1204522	Imputed	C	GEN	422					0.09565	0.9533	0.9146	0.34834	0.35326	0.34454	24	82	78	28	108	102
  rs1204524	Imputed	A	GEN	422					0.09565	0.9533	0.9146	0.34834	0.35326	0.34454	24	82	78	28	108	102
  rs12153185	Imputed	T	DOM	441	0.5728	0.2023	0.3853	0.8516	−2.754	0.00589	0.07489	0.35034	0.31316	0.37849	27	65	98	36	118	97
  rs12182651	Imputed	T	ADD	441	0.982	0.2314	0.624	1.545	−0.07863	0.9373	0.07328	0.0907	0.08947	0.09163	3	28	159	4	38	209
  rs12182651	Imputed	T	DOM	441	0.9744	0.2621	0.583	1.629	−0.09893	0.9212	0.07328	0.0907	0.08947	0.09163	3	28	159	4	38	209
  rs12193568	Imputed	G	DOM	361	1.618	0.2464	0.9984	2.623	1.953	0.05077	0.1009	0.14958	0.17296	0.13119	5	45	109	7	39	156
  rs12264914	Imputed	C	DOM	311	0.4742	0.2385	0.2971	0.7568	−3.128	0.00176	1	0.25723	0.20652	0.29769	8	41	89	12	79	82
  rs12307767	Imputed	C	DOM	419	0.6033	0.203	0.4053	0.8981	−2.489	0.0128	0.8317	0.3568	0.31564	0.3875	20	73	86	32	122	86
  rs1232298	Imputed	G	REC	408	1.995	0.3003	1.107	3.593	2.299	0.0215	0.08143	0.34681	0.38483	0.31739	33	71	74	24	98	108
  rs12407412	Imputed	C	ADD	441	1.439	0.1975	0.977	2.119	1.842	0.06547	0.01289	0.12358	0.15	0.10359	7	43	140	6	40	205
  rs12407412	Imputed	C	DOM	441	1.57	0.2354	0.9899	2.491	1.917	0.05525	0.01289	0.12358	0.15	0.10359	7	43	140	6	40	205
  rs12420184	Imputed	G	DOM	438	1.429	0.2168	0.9343	2.185	1.647	0.09966	1	0.14954	0.16931	0.13454	4	56	129	5	57	187
  rs12422750	Imputed	A	DOM	442	0.5888	0.1966	0.4005	0.8656	−2.694	0.00706	0.2411	0.33597	0.29474	0.36706	17	78	95	27	131	94
  rs12446951	Imputed	A	ADD	310	1.549	0.2897	0.8777	2.732	1.51	0.1312	0.7534	0.10161	0.12411	0.08284	1	33	107	1	26	142
  rs12446951	Imputed	A	DOM	310	1.63	0.2998	0.9057	2.933	1.63	0.1032	0.7534	0.10161	0.12411	0.08284	1	33	107	1	26	142
  rs12457400	Imputed	G	DOM	443	0.578	0.2524	0.3525	0.948	−2.172	0.02987	0.8041	0.10497	0.08115	0.12302	2	27	162	2	58	192
  rs1247340	Imputed	C	DOM	441	0.9041	0.2098	0.5993	1.364	−0.4802	0.6311	0.0397	0.20522	0.17895	0.2251	4	60	126	22	69	160
  rs1247341	Imputed	C	DOM	441	0.919	0.2102	0.6087	1.387	−0.4021	0.6876	0.05636	0.20408	0.18063	0.222	4	61	126	21	69	160
  rs12521291	Imputed	G	ADD	435	1.07	0.1477	0.8008	1.429	0.4556	0.6486	0.9172	0.35747	0.36559	0.35141	21	94	71	35	105	109
  rs12526849	Imputed	T	ADD	436	1.012	0.1389	0.7712	1.329	0.08887	0.9292	0.4209	0.39106	0.39362	0.38911	34	80	74	37	119	92
  rs12526849	Imputed	T	GEN	436					1.863	0.394	0.4209	0.39106	0.39362	0.38911	34	80	74	37	119	92
  rs12543110	Imputed	G	DOM	443	1.32	0.1941	0.9026	1.931	1.432	0.1521	0.6236	0.26298	0.27487	0.25397	9	87	95	19	90	143
  rs12678600	Imputed	A	DOM	439	0.7992	0.198	0.5421	1.178	−1.132	0.2575	1	0.31663	0.29894	0.33	18	77	94	26	113	111
  rs12719415	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs12831292	Imputed	G	DOM	436	0.7047	0.2039	0.4725	1.051	−1.716	0.08609	1	0.40367	0.37097	0.428	26	86	74	45	124	81
  rs12923993	Imputed	C	DOM	443	2.011	0.2218	1.302	3.107	3.15	0.00163	0.4471	0.14447	0.17801	0.11905	3	62	126	8	44	200
  rs12936964	Imputed	T	DOM	431	1.123	0.2052	0.7508	1.678	0.5634	0.5732	0.2205	0.38167	0.37097	0.3898	23	92	71	46	99	100
  rs12960663	Imputed	G	ADD	435	0.797	0.1843	0.5553	1.144	−1.231	0.2182	0.8698	0.17701	0.15775	0.19153	3	53	131	11	73	164
  rs13038146	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs13038146	Imputed	C	GEN	443					6.692	0.03523	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs13134222	Imputed	A	GEN	442					4.511	0.1048	0.6117	0.24887	0.28158	0.22421	13	81	96	12	89	151
  rs13172910	Imputed	A	DOM	417	0.6398	0.2054	0.4278	0.9571	−2.174	0.02974	1	0.2446	0.21858	0.26496	12	56	115	13	98	123
  rs13194907	Imputed	A	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs13194907	Imputed	A	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs13195745	Imputed	A	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs13195745	Imputed	A	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs1321432	Imputed	A	REC	443	0.9755	0.2643	0.5811	1.638	−0.09385	0.9252	0.108	0.38036	0.37696	0.38294	31	82	78	41	111	100
  rs1321457	Imputed	G	REC	435	0.9425	0.2789	0.5456	1.628	−0.2122	0.8319	0.3005	0.36207	0.3617	0.36235	26	84	78	36	107	104
  rs13265054	Imputed	T	DOM	434	0.7541	0.1998	0.5098	1.116	−1.413	0.1577	0.8248	0.31567	0.29412	0.33198	17	76	94	25	114	108
  rs13282131	Imputed	C	GEN	440					6.641	0.03614	0.8464	0.43864	0.47105	0.414	47	85	58	39	129	82
  rs13353526	Imputed	C	DOM	438	0.8239	0.2338	0.521	1.303	−0.8286	0.4073	1	0.12785	0.11842	0.13508	2	41	147	5	57	186
  rs1336382	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131	0.1655	0.33409	0.36911	0.30754	29	83	79	27	101	124
  rs1336383	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131	0.1655	0.33409	0.36911	0.30754	29	83	79	27	101	124
  rs1336407	Imputed	T	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129	0.1663	0.33484	0.36911	0.30876	29	83	79	27	101	123
  rs1336409	Imputed	T	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129	0.1663	0.33484	0.36911	0.30876	29	83	79	27	101	123
  rs1336596	Imputed	A	DOM	440	0.9849	0.205	0.659	1.472	−0.07439	0.9407	0.4737	0.36932	0.37632	0.364	28	87	75	28	126	96
  rs1343560	Imputed	T	ADD	437	1.717	0.2225	1.11	2.656	2.43	0.01509	0.1757	0.11899	0.14894	0.09639	2	52	134	1	46	202
  rs1343560	Imputed	T	DOM	437	1.745	0.2319	1.108	2.75	2.402	0.0163	0.1757	0.11899	0.14894	0.09639	2	52	134	1	46	202
  rs1361987	Imputed	T	GEN	443					0.4112	0.8142	0.8328	0.34199	0.34817	0.3373	25	83	83	28	114	110
  rs1386153	Imputed	T	ADD	441	0.8596	0.1501	0.6405	1.154	−1.008	0.3137	0.3322	0.32993	0.31316	0.34263	16	87	87	27	118	106
  rs1386153	Imputed	T	DOM	441	0.8546	0.1947	0.5835	1.252	−0.8069	0.4197	0.3322	0.32993	0.31316	0.34263	16	87	87	27	118	106
  rs1394015	Imputed	C	DOM	372	2.85	1.231	0.2552	31.84	0.8507	0.3949	1	0.00403	0.00633	0.00234	0	2	156	0	1	213
  rs1407038	Imputed	A	REC	443	0.9523	0.2749	0.5556	1.632	−0.178	0.8588	0.1496	0.35892	0.35864	0.35913	27	83	81	37	107	108
  rs1407039	Imputed	A	REC	443	0.9755	0.2643	0.5811	1.638	−0.09385	0.9252	0.108	0.38036	0.37696	0.38294	31	82	78	41	111	100
  rs1412802	Imputed	T	GEN	428					3.851	0.1458	0.7178	0.27804	0.25543	0.29508	8	78	98	23	98	123
  rs1414865	Imputed	T	DOM	442	1.352	0.1976	0.9177	1.991	1.525	0.1272	0.1377	0.33937	0.37173	0.31474	29	84	78	29	100	122
  rs1414873	Imputed	A	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129	0.1663	0.33484	0.36911	0.30876	29	83	79	27	101	123
  rs1414876	Imputed	C	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129	0.1663	0.33484	0.36911	0.30876	29	83	79	27	101	123
  rs1418671	Imputed	C	REC	424	1.095	0.2783	0.6345	1.889	0.3255	0.7448	0.6846	0.39623	0.4011	0.39256	29	88	65	35	120	87
  rs1419490	Genotyped	T	GEN	443					0.3173	0.8533	1	0.33634	0.3377	0.33532	23	83	85	27	115	110
  rs1434507	Imputed	A	ADD	442	1.053	0.1646	0.7624	1.453	0.3112	0.7556	1	0.22624	0.23037	0.22311	9	70	112	13	86	152
  rs1434508	Imputed	T	ADD	442	1.053	0.1646	0.7624	1.453	0.3112	0.7556	1	0.22624	0.23037	0.22311	9	70	112	13	86	152
  rs1435205	Imputed	A	ADD	442	1.021	0.1625	0.7424	1.404	0.1273	0.8987	0.8924	0.22624	0.22895	0.22421	10	67	113	13	87	152
  rs1443928	Imputed	C	REC	435	0.9918	0.2124	0.6541	1.504	−0.03862	0.9692	0.1711	0.57126	0.56806	0.57377	65	87	39	84	112	48
  rs1452235	Imputed	G	GEN	443					5.506	0.06375	0.5227	0.33296	0.36911	0.30556	30	81	80	22	110	120
  rs1452236	Imputed	G	GEN	443					5.506	0.06375	0.5227	0.33296	0.36911	0.30556	30	81	80	22	110	120
  rs1452237	Imputed	G	GEN	443					5.506	0.06375	0.5227	0.33296	0.36911	0.30556	30	81	80	22	110	120
  rs1452243	Genotyped	T	GEN	443					5.995	0.04992	0.6732	0.33973	0.37435	0.31349	31	81	79	22	114	116
  rs1463768	Genotyped	G	REC	443	1.844	0.2673	1.092	3.114	2.29	0.02201	0.5464	0.38262	0.42932	0.34722	38	88	65	30	115	107
  rs1463769	Imputed	G	REC	443	1.844	0.2673	1.092	3.114	2.29	0.02201	0.5464	0.38262	0.42932	0.34722	38	88	65	30	115	107
  rs1472435	Imputed	A	ADD	437	0.5361	0.3365	0.2772	1.037	−1.853	0.0639	0.6259	0.05378	0.03704	0.06653	0	14	175	0	33	215
  rs1472435	Imputed	A	DOM	437	0.5361	0.3365	0.2772	1.037	−1.853	0.0639	0.6259	0.05378	0.03704	0.06653	0	14	175	0	33	215
  rs1476714	Imputed	A	DOM	439	0.5924	0.2025	0.3983	0.8811	−2.585	0.00974	0.1129	0.3451	0.31316	0.36948	27	65	98	33	118	98
  rs1495159	Imputed	G	ADD	429	1.318	0.1505	0.9813	1.77	1.835	0.06656	0.6567	0.31935	0.35135	0.29508	18	94	73	28	88	128
  rs1495159	Imputed	G	GEN	429					9.642	0.00806	0.6567	0.31935	0.35135	0.29508	18	94	73	28	88	128
  rs1495375	Imputed	A	DOM	421	0.7102	0.2081	0.4724	1.068	−1.644	0.1001	0.9197	0.40855	0.37297	0.43644	26	86	73	45	116	75
  rs1495376	Imputed	T	DOM	424	0.774	0.2264	0.4966	1.206	−1.132	0.2577	0.3834	0.48231	0.45652	0.50208	36	96	52	58	125	57
  rs1495377	Imputed	G	DOM	425	0.7814	0.2265	0.5013	1.218	−1.089	0.2762	0.4372	0.48118	0.45652	0.5	36	96	52	58	125	58
  rs1495381	Imputed	T	GEN	442					7.762	0.02063	0.2705	0.38575	0.43421	0.34921	35	95	60	25	126	101
  rs1495381	Imputed	T	REC	442	2.08	0.2834 1	.194	3.626	2.584	0.00975	0.2705	0.38575	0.43421	0.34921	35	95	60	25	126	101
  rs1498992	Imputed	G	DOM	428	0.7274	0.1999	0.4916	1.076	−1.592	0.1114	0.4588	0.35047	0.32337	0.3709	22	75	87	34	113	97
  rs1499001	Imputed	T	DOM	437	0.7573	0.1974	0.5144	1.115	−1.409	0.159	0.2889	0.28375	0.26203	0.3	16	66	105	24	102	124
  rs1512988	Imputed	A	DOM	442	0.7185	0.204	0.4817	1.072	−1.621	0.1051	0.6908	0.3948	0.36316	0.41865	26	86	78	45	121	86
  rs1512989	Imputed	T	DOM	442	0.7185	0.204	0.4817	1.072	−1.621	0.1051	0.6908	0.3948	0.36316	0.41865	26	86	78	45	121	86
  rs1512991	Imputed	T	ADD	425	0.7106	0.1399	0.5401	0.9348	−2.442	0.01462	0.3804	0.45647	0.4071	0.4938	30	89	64	63	113	66
  rs1512991	Imputed	T	DOM	425	0.6965	0.2131	0.4587	1.057	−1.698	0.08957	0.3804	0.45647	0.4071	0.4938	30	89	64	63	113	66
  rs1516855	Imputed	G	REC	398	1.236	0.2928	0.6964	2.195	0.7243	0.4689	0.2364	0.36935	0.38571	0.3565	29	77	69	31	97	95
  rs1527450	Imputed	T	ADD	441	1.146	0.1493	0.8556	1.536	0.9151	0.3601	0.6792	0.35714	0.37302	0.34524	25	91	73	29	116	107
  rs1527450	Imputed	T	GEN	441					0.8647	0.649	0.6792	0.35714	0.37302	0.34524	25	91	73	29	116	107
  rs1567740	Imputed	T	DOM	439	0.7204	0.2038	0.4831	1.074	−1.609	0.1076	0.8422	0.39863	0.36579	0.42369	26	87	77	45	121	83
  rs1572573	Imputed	A	ADD	396	1.012	0.2009	0.6826	1.501	0.05984	0.9523	0.00264	0.18813	0.18786	0.18834	2	61	110	3	78	142
  rs1572573	Imputed	A	DOM	396	1.019	0.2128	0.6715	1.546	0.08849	0.9295	0.00264	0.18813	0.18786	0.18834	2	61	110	3	78	142
  rs1584003	Imputed	C	DOM	432	0.6043	0.2157	0.396	0.9221	−2.336	0.0195	0.2438	0.45255	0.42063	0.47737	35	89	65	47	138	58
  rs1584005	Imputed	C	DOM	427	0.6032	0.2163	0.3947	0.9217	−2.337	0.01944	0.2831	0.45082	0.41979	0.475	35	87	65	46	136	58
  rs1585771	Imputed	G	ADD	433	0.9914	0.1575	0.728	1.35	−0.05515	0.956	1	0.26559	0.26486	0.26613	13	72	100	17	98	133
  rs1592015	Imputed	G	DOM	443	1.138	0.2135	0.7487	1.729	0.6045	0.5455	0.2352	0.16817	0.17801	0.16071	8	52	131	8	65	179
  rs1594885	Imputed	A	ADD	440	1.083	0.1634	0.7863	1.492	0.4891	0.6248	0.7887	0.23182	0.23947	0.226	9	73	108	13	87	150
  rs1603232	Imputed	A	DOM	412	0.7502	0.2319	0.4761	1.182	−1.239	0.2152	0.49	0.49029	0.46111	0.51293	36	94	50	59	120	53
  rs1614565	Imputed	C	DOM	439	0.7578	0.2237	0.4888	1.175	−1.24	0.2151	0.6336	0.49089	0.46296	0.512	39	97	53	64	128	58
  rs1648200	Imputed	G	ADD	411	1.299	0.1675	0.9357	1.804	1.563	0.118	1	0.24331	0.26816	0.22414	14	68	97	10	84	138
  rs16877387	Imputed	C	GEN	436					2.224	0.3289	0.5854	0.32569	0.31649	0.33266	23	73	92	26	113	109
  rs16877387	Imputed	C	REC	436	1.186	0.3054	0.6518	2.158	0.5586	0.5764	0.5854	0.32569	0.31649	0.33266	23	73	92	26	113	109
  rs16938626	Imputed	G	DOM	435	0.7689	0.1982	0.5213	1.134	−1.326	0.1849	0.3923	0.26552	0.24866	0.27823	15	63	109	19	100	129
  rs1694334	Imputed	G	ADD	399	1.156	0.1835	0.8068	1.657	0.7904	0.4293	0.5371	0.20426	0.21765	0.19432	7	60	103	7	75	147
  rs16998821	Imputed	C	DOM	443	1.138	0.2135	0.7487	1.729	0.6045	0.5455	0.2352	0.16817	0.17801	0.16071	8	52	131	8	65	179
  rs1700400	Imputed	T	ADD	417	0.9427	0.1613	0.6872	1.293	−0.3659	0.7144	0.1293	0.23141	0.22652	0.23517	12	58	111	16	79	141
  rs17007620	Imputed	G	ADD	408	1.033	0.1717	0.7377	1.446	0.1877	0.8511	1	0.22181	0.22599	0.21861	7	66	104	13	75	143
  rs17007620	Imputed	G	DOM	408	1.127	0.206	0.7523	1.687	0.5784	0.563	1	0.22181	0.22599	0.21861	7	66	104	13	75	143
  rs17023290	Imputed	C	DOM	443	0.8286	0.2404	0.5173	1.327	−0.7821	0.4342	0.8039	0.10722	0.09686	0.11508	1	35	155	3	52	197
  rs17047957	Imputed	C	DOM	439	1.801	0.2129	1.187	2.734	2.765	0.0057	0.6092	0.16856	0.20635	0.14	7	64	118	7	56	187
  rs1705237	Imputed	A	DOM	439	0.7578	0.2237	0.4888	1.175	−1.24	0.2151	0.6336	0.49089	0.46296	0.512	39	97	53	64	128	58
  rs1705261	Imputed	A	GEN	442					7.113	0.02854	0.5499	0.39367	0.43947	0.35913	37	93	60	28	125	99
  rs1705261	Imputed	A	REC	442	2.005	0.2767	1.166	3.449	2.514	0.01192	0.5499	0.39367	0.43947	0.35913	37	93	60	28	125	99
  rs17076972	Imputed	C	ADD	442	1.031	0.1393	0.7845	1.355	0.2183	0.8272	0.5032	0.45814	0.46335	0.45418	38	101	52	51	126	74
  rs17076972	Imputed	C	GEN	442					0.2344	0.8894	0.5032	0.45814	0.46335	0.45418	38	101	52	51	126	74
  rs17076972	Imputed	C	REC	442	0.9776	0.2403	0.6104	1.566	−0.09436	0.9248	0.5032	0.45814	0.46335	0.45418	38	101	52	51	126	74
  rs17189710	Imputed	T	ADD	430	1.382	0.1457	1.039	1.839	2.22	0.02639	0.3369	0.34535	0.38649	0.31429	33	77	75	23	108	114
  rs17189710	Imputed	T	GEN	430					6.752	0.03418	0.3369	0.34535	0.38649	0.31429	33	77	75	23	108	114
  rs17196143	Imputed	A	ADD	443	0.7066	0.186	0.4907	1.017	−1.867	0.06189	1	0.17946	0.15183	0.2004	2	54	135	12	77	163
  rs17353809	Imputed	G	ADD	433	0.9859	0.1679	0.7095	1.37	−0.0846	0.9326	0.569	0.21478	0.21351	0.21573	10	59	116	12	83	153
  rs17368986	Imputed	A	GEN	442					1.393	0.4984	0.6226	0.17534	0.19211	0.1627	7	59	124	8	66	178
  rs17369097	Imputed	A	GEN	443					1.248	0.5357	0.6275	0.17946	0.19634	0.16667	8	59	124	8	68	176
  rs17434511	Imputed	C	GEN	442					1.393	0.4984	0.6226	0.17534	0.19211	0.1627	7	59	124	8	66	178
  rs17434589	Imputed	C	GEN	442					1.393	0.4984	0.6226	0.17534	0.19211	0.1627	7	59	124	8	66	178
  rs17434603	Imputed	G	GEN	442					1.393	0.4984	0.6226	0.17534	0.19211	0.1627	7	59	124	8	66	178
  rs17434840	Imputed	C	GEN	443					1.248	0.5357	0.6275	0.17946	0.19634	0.16667	8	59	124	8	68	176
  rs17446418	Imputed	G	DOM	380	1.044	0.2158	0.6838	1.593	0.1982	0.8429	0.03708	0.32895	0.33537	0.32407	14	82	68	18	104	94
  rs17530747	Imputed	T	DOM	374	1.033	0.2172	0.6751	1.582	0.1511	0.8799	0.0203	0.3369	0.34375	0.33178	14	82	64	18	106	90
  rs17604285	Imputed	C	ADD	443	0.9476	0.2663	0.5622	1.597	−0.2023	0.8397	0.09538	0.07788	0.07592	0.07937	0	29	162	0	40	212
  rs17604285	Imputed	C	DOM	443	0.9476	0.2663	0.5622	1.597	−0.2023	0.8397	0.09538	0.07788	0.07592	0.07937	0	29	162	0	40	212
  rs17662322	Imputed	T	DOM	443	0.7561	0.2081	0.5029	1.137	−1.344	0.179	0.8723	0.18059	0.15969	0.19643	5	51	135	10	79	163
  rs17769826	Imputed	T	ADD	433	0.9859	0.1679	0.7095	1.37	−0.0846	0.9326	0.569	0.21478	0.21351	0.21573	10	59	116	12	83	153
  rs17821641	Imputed	T	ADD	442	1.021	0.1625	0.7424	1.404	0.1273	0.8987	0.8924	0.22624	0.22895	0.22421	10	67	113	13	87	152
  rs1782328	Imputed	A	ADD	426	0.96	0.1915	0.6595	1.397	−0.213	0.8313	0.305	0.17136	0.16758	0.17418	5	51	126	4	77	163
  rs1796337	Imputed	T	DOM	428	0.6991	0.2365	0.4398	1.111	−1.514	0.1301	0.1753	0.51285	0.47581	0.54132	38	101	47	67	128	47
  rs1798083	Imputed	C	DOM	441	0.7428	0.2255	0.4774	1.156	−1.318	0.1874	0.7038	0.5	0.47105	0.52191	41	97	52	67	128	56
  rs1798085	Imputed	T	DOM	439	0.7578	0.2237	0.4888	1.175	−1.24	0.2151	0.6336	0.49089	0.46296	0.512	39	97	53	64	128	58
  rs1798086	Imputed	T	DOM	416	0.7565	0.2341	0.4781	1.197	−1.192	0.2332	0.6948	0.50361	0.47826	0.52371	41	94	49	62	119	51
  rs1798089	Imputed	C	GEN	366					2.947	0.2291	2.13E−06	0.29235	0.31908	0.27336	8	81	63	5	107	102
  rs1798089	Imputed	C	REC	366	2.307	0.5861	0.7314	7.277	1.426	0.1538	2.13E−06	0.29235	0.31908	0.27336	8	81	63	5	107	102
  rs1798090	Imputed	C	GEN	367					3.038	0.2189	1.37E−06	0.29292	0.32026	0.27336	8	82	63	5	107	102
  rs1798090	Imputed	C	REC	367	2.295	0.5861	0.7275	7.238	1.417	0.1564	1.37E−06	0.29292	0.32026	0.27336	8	82	63	5	107	102
  rs1832222	Imputed	G	DOM	443	1.344	0.1965	0.9144	1.975	1.504	0.1325	0.2005	0.33521	0.36911	0.30952	29	83	79	27	102	123
  rs1838104	Imputed	A	ADD	440	0.9138	0.1404	0.694	1.203	−0.6418	0.521	0.5608	0.56591	0.55526	0.574	61	89	40	83	121	46
  rs1838104	Imputed	A	GEN	440					0.6345	0.7281	0.5608	0.56591	0.55526	0.574	61	89	40	83	121	46
  rs1868616	Imputed	G	ADD	437	0.8179	0.1786	0.5764	1.161	−1.126	0.2602	0.8751	0.18764	0.17021	0.2008	6	52	130	10	80	159
  rs1874313	Imputed	A	DOM	443	0.7338	0.2032	0.4927	1.093	−1.523	0.1277	0.6922	0.39503	0.36387	0.41865	26	87	78	45	121	86
  rs1884902	Imputed	C	REC	443	0.9755	0.2643	0.5811	1.638	−0.09385	0.9252	0.108	0.38036	0.37696	0.38294	31	82	78	41	111	100
  rs1913201	Imputed	G	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs1913201	Imputed	G	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs1913201	Imputed	G	GEN	432					6.276	0.04338	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs1944279	Imputed	A	ADD	438	1.083	0.1637	0.7858	1.493	0.4879	0.6256	0.7885	0.23174	0.23947	0.22581	9	73	108	13	86	149
  rs198461	Imputed	C	DOM	433	0.5222	0.221	0.3386	0.8052	−2.94	0.00328	0.6307	0.48614	0.43548	0.52429	40	82	64	65	129	53
  rs1987179	Imputed	T	DOM	417	0.5176	0.2237	0.3339	0.8024	−2.944	0.00324	0.8637	0.17266	0.13462	0.20213	6	37	139	7	81	147
  rs1990023	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs2016194	Imputed	G	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs2024789	Imputed	C	ADD	440	0.9942	0.1364	0.7609	1.299	−0.0427	0.9659	0.8491	0.50682	0.50529	0.50797	49	93	47	65	125	61
  rs2024789	Imputed	C	GEN	440					0.0158	0.9921	0.8491	0.50682	0.50529	0.50797	49	93	47	65	125	61
  rs2024902	Imputed	A	ADD	442	1.087	0.2583	0.655	1.803	0.3216	0.7477	0.2797	0.07353	0.07592	0.07171	1	27	163	3	30	218
  rs2024902	Imputed	A	DOM	442	1.157	0.2804	0.6678	2.005	0.52	0.6031	0.2797	0.07353	0.07592	0.07171	1	27	163	3	30	218
  rs2025107	Imputed	A	ADD	442	0.9899	0.2312	0.6292	1.557	−0.04381	0.9651	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs2025107	Imputed	A	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs2025108	Imputed	T	ADD	442	0.9899	0.2312	0.6292	1.557	−0.04381	0.9651	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs2025108	Imputed	T	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs2062448	Imputed	T	ADD	442	0.913	0.2688	0.5391	1.546	−0.3387	0.7348	0.09556	0.07692	0.07368	0.07937	0	28	162	0	40	212
  rs2062448	Imputed	T	DOM	442	0.913	0.2688	0.5391	1.546	−0.3387	0.7348	0.09556	0.07692	0.07368	0.07937	0	28	162	0	40	212
  rs2063591	Imputed	C	ADD	441	0.7255	0.1363	0.5554	0.9478	−2.353	0.01861	0.2947	0.47506	0.42932	0.51	36	92	63	69	117	64
  rs2063591	Imputed	C	DOM	441	0.6936	0.2125	0.4573	1.052	−1.722	0.08515	0.2947	0.47506	0.42932	0.51	36	92	63	69	117	64
  rs2065604	Imputed	C	DOM	443	1.177	0.2597	0.7077	1.959	0.6286	0.5296	0.5598	0.08691	0.09424	0.08135	2	32	157	2	37	213
  rs2066238	Imputed	T	DOM	443	1.138	0.2135	0.7487	1.729	0.6045	0.5455	0.2352	0.16817	0.17801	0.16071	8	52	131	8	65	179
  rs2068051	Imputed	G	ADD	269	0.9214	0.1888	0.6364	1.334	−0.4337	0.6645	0.3082	0.60223	0.59009	0.61076	36	59	16	57	79	22
  rs2068051	Imputed	G	GEN	269					0.367	0.8324	0.3082	0.60223	0.59009	0.61076	36	59	16	57	79	22
  rs2077702	Genotyped	G	GEN	443					8.422	0.01483	0.4324	0.30361	0.3534	0.26587	22	91	78	15	104	133
  rs208757	Imputed	G	ADD	435	1.552	0.175	1.101	2.187	2.512	0.01201	0.6456	0.19425	0.23545	0.1626	8	73	108	10	60	176
  rs208757	Imputed	G	DOM	435	1.858	0.2057	1.241	2.78	3.011	0.0026	0.6456	0.19425	0.23545	0.1626	8	73	108	10	60	176
  rs2095586	Imputed	A	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129	0.3355	0.33145	0.36649	0.30478	28	84	79	25	103	123
  rs2108426	Imputed	C	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs2110664	Imputed	A	DOM	399	1.47	0.2058	0.9818	2.2	1.871	0.06136	1	0.27569	0.30523	0.2533	14	77	81	16	83	128
  rs2132242	Imputed	A	DOM	440	0.6978	0.2022	0.4695	1.037	−1.78	0.07505	1	0.40341	0.36842	0.43	26	88	76	45	125	80
  rs2151644	Imputed	T	DOM	442	1.184	0.2598	0.7118	1.97	0.6512	0.5149	0.7613	0.0871	0.09474	0.08135	2	32	156	2	37	213
  rs2157752	Genotyped	A	GEN	443					0.5489	0.76	0.372	0.30474	0.29843	0.30952	20	74	97	25	106	121
  rs2158958	Imputed	A	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs2158961	Imputed	G	DOM	443	0.6399	0.1948	0.4368	0.9373	−2.293	0.02187	0.8242	0.30813	0.2801	0.32937	20	67	104	23	120	109
  rs2164099	Imputed	G	ADD	441	1.075	0.1633	0.7809	1.481	0.4457	0.6558	0.6902	0.23243	0.23947	0.22709	9	73	108	13	88	150
  rs2173254	Imputed	G	GEN	438					0.524	0.7695	0.9154	0.34132	0.35185	0.33333	22	89	78	28	110	111
  rs2173254	Imputed	G	REC	438	1.019	0.3061	0.5595	1.857	0.06273	0.95	0.9154	0.34132	0.35185	0.33333	22	89	78	28	110	111
  rs2188079	Imputed	C	ADD	443	1.028	0.1399	0.7818	1.353	0.2006	0.841	0.563	0.43905	0.44503	0.43452	39	92	60	43	133	76
  rs2188079	Imputed	C	GEN	443					1.2	0.5489	0.563	0.43905	0.44503	0.43452	39	92	60	43	133	76
  rs2190304	Imputed	G	REC	443	1.465	0.2335	0.9272	2.316	1.636	0.1017	1	0.47517	0.47906	0.47222	50	83	58	50	138	64
  rs2190597	Imputed	T	DOM	440	0.6496	0.2095	0.4309	0.9795	−2.059	0.0395	0.1008	0.44318	0.42021	0.46032	42	74	72	53	126	73
  rs2190598	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs2190600	Imputed	A	DOM	440	0.577	0.2025	0.388	0.8581	−2.716	0.00661	0.07522	0.34886	0.31316	0.376	27	65	98	35	118	97
  rs2218084	Imputed	T	GEN	440					5.731	0.05696	0.3138	0.17159	0.17368	0.17	11	44	135	5	75	170
  rs2218084	Imputed	T	REC	440	2.942	0.5498	1.002	8.643	1.963	0.04966	0.3138	0.17159	0.17368	0.17	11	44	135	5	75	170
  rs2236290	Genotyped	C	GEN	441					6.206	0.04491	0.9174	0.35488	0.31675	0.384	16	89	86	40	112	98
  rs2243860	Imputed	A	GEN	354					2.941	0.2298	0.4422	0.4096	0.44737	0.38119	33	70	49	30	94	78
  rs2243860	Imputed	A	REC	354	1.553	0.289	0.8812	2.736	1.522	0.1279	0.4422	0.4096	0.44737	0.38119	33	70	49	30	94	78
  rs2246564	Imputed	T	DOM	443	1.177	0.2597	0.7077	1.959	0.6286	0.5296	0.5598	0.08691	0.09424	0.08135	2	32	157	2	37	213
  rs2248236	Imputed	C	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.0026	0.8852	0.20655	0.17016	0.23413	9	47	135	9	100	143
  rs2250340	Imputed	T	DOM	410	1.184	0.2617	0.709	1.978	0.6458	0.5184	0.7706	0.0939	0.10169	0.08798	2	32	143	2	37	194
  rs2257192	Imputed	G	DOM	443	1.177	0.2597	0.7077	1.959	0.6286	0.5296	0.5598	0.08691	0.09424	0.08135	2	32	157	2	37	213
  rs2270584	Imputed	A	DOM	441	0.6747	0.2026	0.4536	1.004	−1.942	0.05211	0.4848	0.39342	0.35526	0.42231	26	83	81	46	120	85
  rs2270586	Imputed	A	DOM	442	0.6883	0.2018	0.4634	1.022	−1.851	0.06423	0.4864	0.39367	0.35602	0.42231	26	84	81	46	120	85
  rs2270589	Imputed	A	ADD	391	0.6468	0.1498	0.4822	0.8674	−2.909	0.00362	0.7615	0.48082	0.42059	0.52715	30	83	57	62	109	50
  rs2270589	Imputed	A	DOM	391	0.5799	0.2334	0.367	0.9163	−2.335	0.01956	0.7615	0.48082	0.42059	0.52715	30	83	57	62	109	50
  rs2270589	Imputed	A	GEN	391					8.473	0.01446	0.7615	0.48082	0.42059	0.52715	30	83	57	62	109	50
  rs2296889	Imputed	C	DOM	437	0.9005	0.2162	0.5895	1.376	−0.485	0.6277	0.3269	0.17849	0.18182	0.176	10	48	129	7	74	169
  rs2301346	Imputed	C	ADD	357	1.001	0.1711	0.7159	1.4	0.005922	0.9953	0.4976	0.26611	0.26563	0.2665	12	61	87	16	73	108
  rs2301346	Imputed	C	DOM	357	1.026	0.2191	0.6675	1.576	0.1152	0.9083	0.4976	0.26611	0.26563	0.2665	12	61	87	16	73	108
  rs2327929	Imputed	G	REC	441	1.411	0.2475	0.8684	2.291	1.39	0.1645	0.4376	0.42857	0.44764	0.414	42	87	62	43	121	86
  rs2357486	Imputed	C	REC	436	0.8855	0.316	0.4766	1.645	−0.385	0.7003	0.9136	0.32683	0.32181	0.33065	19	83	86	28	108	112
  rs2373793	Imputed	G	DOM	435	1.599	0.2233	1.032	2.477	2.103	0.03546	1	0.14253	0.17368	0.11837	6	54	130	3	52	190
  rs2377622	Imputed	T	GEN	291					8.41	0.01492	1	0.38832	0.33333	0.42857	10	62	51	34	76	58
  rs2377622	Imputed	T	REC	291	0.2954	0.4232	0.1289	0.677	−2.882	0.00396	1	0.38832	0.33333	0.42857	10	62	51	34	76	58
  rs2383903	Imputed	G	DOM	443	0.7568	0.1968	0.5146	1.113	−1.416	0.1569	0.4634	0.26411	0.24607	0.27778	15	64	112	19	102	131
  rs2389866	Imputed	C	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.0026	0.8852	0.20655	0.17016	0.23413	9	47	135	9	100	143
  rs2389869	Imputed	C	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.0026	0.8852	0.20655	0.17016	0.23413	9	47	135	9	100	143
  rs2418541	Imputed	A	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs2418542	Imputed	A	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs2418548	Imputed	C	DOM	442	0.6036	0.2017	0.4065	0.8963	−2.503	0.01231	0.01683	0.35633	0.32199	0.38247	29	65	97	39	114	98
  rs2476976	Imputed	C	DOM	442	1.391	0.1963	0.9466	2.044	1.68	0.09288	0.2817	0.32919	0.36387	0.30279	27	85	79	26	100	125
  rs2483639	Imputed	A	DOM	443	1.177	0.2597	0.7077	1.959	0.6286	0.5296	0.5598	0.08691	0.09424	0.08135	2	32	157	2	37	213
  rs2483640	Imputed	A	DOM	443	1.177	0.2597	0.7077	1.959	0.6286	0.5296	0.5598	0.08691	0.09424	0.08135	2	32	157	2	37	213
  rs2544780	Imputed	T	REC	442	3.054	0.3822	1.444	6.46	2.921	0.00349	0.3055	0.29638	0.33246	0.26892	23	81	87	11	113	127
  rs2586458	Imputed	T	DOM	372	1.439	0.2465	0.8877	2.333	1.477	0.1397	1	0.13172	0.14744	0.12037	2	42	112	4	44	168
  rs2593272	Imputed	G	ADD	443	0.9033	0.1559	0.6654	1.226	−0.6524	0.5141	0.1147	0.23702	0.22775	0.24405	12	63	116	19	85	148
  rs2593273	Imputed	T	ADD	426	0.9769	0.1588	0.7156	1.334	−0.1474	0.8828	0.03674	0.22418	0.2234	0.22479	12	60	116	17	73	148
  rs2622499	Imputed	G	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.0026	0.8852	0.20655	0.17016	0.23413	9	47	135	9	100	143
  rs264126	Imputed	C	DOM	439	0.6379	0.2093	0.4232	0.9615	−2.148	0.03174	0.08131	0.44191	0.41755	0.46016	42	73	73	53	125	73
  rs264129	Imputed	T	DOM	443	0.6399	0.1948	0.4368	0.9373	−2.293	0.02187	0.8242	0.30813	0.2801	0.32937	20	67	104	23	120	109
  rs2656822	Imputed	T	ADD	443	0.9033	0.1559	0.6654	1.226	−0.6524	0.5141	0.1147	0.23702	0.22775	0.24405	12	63	116	19	85	148
  rs2656823	Imputed	G	ADD	443	0.9033	0.1559	0.6654	1.226	−0.6524	0.5141	0.1147	0.23702	0.22775	0.24405	12	63	116	19	85	148
  rs2656825	Imputed	T	ADD	420	0.986	0.1592	0.7217	1.347	−0.08844	0.9295	0.03522	0.225	0.2246	0.22532	12	60	115	17	71	145
  rs2764766	Imputed	C	REC	443	3.069	0.3822	1.451	6.491	2.934	0.00335	0.3053	0.29684	0.33246	0.26984	23	81	87	11	114	127
  rs2793101	Imputed	T	ADD	442	1.081	0.236	0.6809	1.717	0.3309	0.7407	0.7843	0.09615	0.09948	0.09363	2	34	155	1	45	205
  rs2793101	Imputed	T	DOM	442	1.046	0.2497	0.6414	1.707	0.1818	0.8557	0.7843	0.09615	0.09948	0.09363	2	34	155	1	45	205
  rs2795871	Imputed	A	ADD	435	0.5722	0.339	0.2944	1.112	−1.647	0.09966	0.6186	0.05172	0.03763	0.06225	0	14	172	0	31	218
  rs2795886	Imputed	A	ADD	442	0.5272	0.3735	0.2535	1.096	−1.714	0.08652	1	0.04299	0.02895	0.05357	0	11	179	0	27	225
  rs2795886	Imputed	A	DOM	442	0.5272	0.3735	0.2535	1.096	−1.714	0.08652	1	0.04299	0.02895	0.05357	0	11	179	0	27	225
  rs2859994	Imputed	C	GEN	436					0.8834	0.643	0.4109	0.36927	0.37234	0.36694	22	96	70	33	116	99
  rs2870464	Imputed	G	DOM	441	1.969	0.2225	1.273	3.045	3.045	0.00233	0.4419	0.14399	0.17632	0.11952	3	61	126	8	44	199
  rs2875528	Imputed	T	DOM	443	0.8843	0.2352	0.5577	1.402	−0.5227	0.6012	1	0.11851	0.10995	0.125	1	40	150	5	53	194
  rs2876227	Imputed	C	ADD	442	1.389	0.1445	1.046	1.843	2.272	0.02309	0.4631	0.34502	0.38743	0.31275	33	82	76	23	111	117
  rs2876227	Imputed	C	GEN	442					6.593	0.03701	0.4631	0.34502	0.38743	0.31275	33	82	76	23	111	117
  rs2882097	Imputed	A	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131	0.1655	0.33409	0.36911	0.30754	29	83	79	27	101	124
  rs2921983	Imputed	C	ADD	416	0.8945	0.167	0.6448	1.241	−0.6677	0.5043	0.2479	0.21755	0.20718	0.22553	9	57	115	15	76	144
  rs2987537	Imputed	C	DOM	438	1.58	0.2184	1.03	2.424	2.095	0.03621	0.718	0.15753	0.18617	0.136	6	58	124	6	56	188
  rs2996416	Imputed	C	ADD	438	1.725	0.2225	1.115	2.668	2.451	0.01426	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs2996416	Imputed	C	DOM	438	1.754	0.2318	1.113	2.762	2.423	0.01539	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs3015527	Imputed	C	ADD	398	1.884	0.2353	1.188	2.989	2.693	0.00708	0.3323	0.11558	0.15029	0.08889	2	48	123	1	38	186
  rs3015527	Imputed	C	DOM	398	1.945	0.2451	1.203	3.144	2.714	0.00664	0.3323	0.11558	0.15029	0.08889	2	48	123	1	38	186
  rs3015530	Imputed	C	ADD	438	1.725	0.2225	1.115	2.668	2.451	0.01426	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs3015530	Imputed	C	DOM	438	1.754	0.2318	1.113	2.762	2.423	0.01539	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs3015531	Imputed	T	ADD	438	1.725	0.2225	1.115	2.668	2.451	0.01426	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs3015531	Imputed	T	DOM	438	1.754	0.2318	1.113	2.762	2.423	0.01539	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs3015535	Imputed	C	ADD	438	1.725	0.2225	1.115	2.668	2.451	0.01426	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs3015535	Imputed	C	DOM	438	1.754	0.2318	1.113	2.762	2.423	0.01539	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs3019407	Imputed	A	GEN	439					0.7217	0.6971	1	0.33941	0.35185	0.33	22	89	78	28	109	113
  rs3019407	Imputed	A	REC	439	1.025	0.306	0.5627	1.867	0.08058	0.9358	1	0.33941	0.35185	0.33	22	89	78	28	109	113
  rs36071725	Genotyped	C	GEN	443					0.6419	0.7255	0.5846	0.31828	0.31414	0.32143	16	88	87	26	110	116
  rs373983	Imputed	G	DOM	414	1.954	0.2168	1.277	2.988	3.089	0.00201	0.9193	0.41063	0.45355	0.37662	31	104	48	38	98	95
  rs3756154	Imputed	C	DOM	416	0.5162	0.2209	0.3348	0.7959	−2.993	0.00276	1	0.17668	0.13736	0.20726	6	38	138	7	83	144
  rs3793044	Imputed	C	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs3793044	Imputed	C	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs3793053	Imputed	C	ADD	436	0.995	0.236	0.6266	1.58	−0.02103	0.9832	0.06405	0.0883	0.08777	0.08871	3	27	158	4	36	208
  rs3793053	Imputed	C	DOM	436	0.9919	0.2675	0.5872	1.676	−0.03035	0.9758	0.06405	0.0883	0.08777	0.08871	3	27	158	4	36	208
  rs3796246	Imputed	G	ADD	442	0.9554	0.2625	0.5711	1.598	−0.1737	0.8621	0.5013	0.07805	0.07592	0.07968	0	29	162	1	38	212
  rs3796246	Imputed	G	DOM	442	0.9829	0.2682	0.5811	1.663	−0.06425	0.9488	0.5013	0.07805	0.07592	0.07968	0	29	162	1	38	212
  rs3805996	Imputed	G	ADD	421	1.042	0.2655	0.6195	1.754	0.1561	0.876	0.2844	0.07601	0.07692	0.07531	1	26	155	3	30	206
  rs3805996	Imputed	G	DOM	421	1.106	0.2862	0.631	1.938	0.3512	0.7254	0.2844	0.07601	0.07692	0.07531	1	26	155	3	30	206
  rs3806003	Imputed	A	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs3806003	Imputed	A	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923	0.279	0.07336	0.07592	0.07143	1	27	163	3	30	219
  rs3806004	Imputed	T	ADD	442	0.9899	0.2312	0.6292	1.557	−0.04381	0.9651	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs3806004	Imputed	T	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs3806010	Imputed	T	ADD	442	0.9899	0.2312	0.6292	1.557	−0.04381	0.9651	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs3806010	Imputed	T	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs3806014	Imputed	T	ADD	430	1.014	0.234	0.6412	1.605	0.06078	0.9515	0.06876	0.0907	0.09016	0.09109	3	27	153	4	37	206
  rs3806014	Imputed	T	DOM	430	1.002	0.2658	0.5954	1.688	0.008889	0.9929	0.06876	0.0907	0.09016	0.09109	3	27	153	4	37	206
  rs3806015	Imputed	A	ADD	426	1.004	0.2345	0.634	1.589	0.01643	0.9869	0.07007	0.09155	0.09066	0.09221	3	27	152	4	37	203
  rs3806015	Imputed	A	DOM	426	0.9945	0.2663	0.5902	1.676	−0.02059	0.9836	0.07007	0.09155	0.09066	0.09221	3	27	152	4	37	203
  rs3806018	Imputed	A	ADD	442	0.9899	0.2312	0.6292	1.557	−0.04381	0.9651	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs3806018	Imputed	A	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446	0.0729	0.0905	0.08947	0.09127	3	28	159	4	38	210
  rs3806019	Imputed	A	ADD	438	0.974	0.2319	0.6182	1.534	−0.1137	0.9095	0.07445	0.09132	0.08995	0.09237	3	28	158	4	38	207
  rs3806019	Imputed	A	DOM	438	0.9676	0.2625	0.5784	1.619	−0.1255	0.9001	0.07445	0.09132	0.08995	0.09237	3	28	158	4	38	207
  rs3806024	Imputed	T	ADD	442	1.029	0.2268	0.6599	1.605	0.1274	0.8986	0.03996	0.09276	0.09424	0.09163	4	28	159	4	38	209
  rs3806024	Imputed	T	DOM	442	1.001	0.2605	0.601	1.669	0.005209	0.9958	0.03996	0.09276	0.09424	0.09163	4	28	159	4	38	209
  rs3847825	Imputed	G	ADD	440	0.7616	0.1432	0.5752	1.008	−1.901	0.05729	1	0.38523	0.34737	0.414	18	96	76	47	113	90
  rs3847825	Imputed	G	GEN	440					6.939	0.03113	1	0.38523	0.34737	0.414	18	96	76	47	113	90
  rs3852001	Genotyped	C	GEN	443					0.9298	0.6282	0.6332	0.18172	0.19634	0.17063	8	59	124	8	70	174
  rs3852001	Genotyped	C	REC	443	1.348	0.5124	0.4937	3.68	0.5827	0.5601	0.6332	0.18172	0.19634	0.17063	8	59	124	8	70	174
  rs3852002	Imputed	G	GEN	443					1.248	0.5357	0.6275	0.17946	0.19634	0.16667	8	59	124	8	68	176
  rs3852002	Imputed	G	REC	443	1.348	0.5124	0.4937	3.68	0.5827	0.5601	0.6275	0.17946	0.19634	0.16667	8	59	124	8	68	176
  rs3852003	Imputed	A	GEN	442					1.289	0.525	0.6277	0.17986	0.19737	0.16667	8	59	123	8	68	176
  rs3852003	Imputed	A	REC	442	1.351	0.5124	0.4947	3.687	0.5864	0.5576	0.6277	0.17986	0.19737	0.16667	8	59	123	8	68	176
  rs3942254	Imputed	T	DOM	420	0.6591	0.2081	0.4383	0.991	−2.004	0.04512	0.1836	0.39167	0.35393	0.41942	26	74	78	45	113	84
  rs3945085	Imputed	A	DOM	441	1.324	0.1969	0.9003	1.948	1.427	0.1537	0.05672	0.34014	0.37435	0.314	31	81	79	29	99	122
  rs399485	Imputed	A	DOM	437	1.648	0.1968	1.12	2.423	2.538	0.01116	0.3195	0.25973	0.29211	0.23482	10	91	89	15	86	146
  rs4029119	Imputed	G	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs4029119	Imputed	G	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs412791	Imputed	C	GEN	432					0.1413	0.9318	0.8291	0.33565	0.33957	0.33265	23	81	83	27	109	109
  rs4146972	Genotyped	T	DOM	443	1.832	0.2123	1.208	2.777	2.851	0.00436	0.7362	0.17043	0.20942	0.14087	7	66	118	7	57	188
  rs4259369	Imputed	C	REC	440	0.659	0.2526	0.4017	1.081	−1.651	0.09871	0.3808	0.42727	0.39005	0.45582	30	89	72	55	117	77
  rs4273613	Imputed	T	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs4273613	Imputed	T	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs4294022	Imputed	C	DOM	441	1.051	0.1977	0.7133	1.548	0.251	0.8018	0.25	0.2483	0.25132	0.24603	14	67	108	18	88	146
  rs4310554	Genotyped	C	DOM	443	1.561	0.2379	0.9794	2.489	1.872	0.06115	0.9242	0.52032	0.55497	0.49405	56	100	35	63	123	66
  rs4315598	Imputed	T	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs4315598	Imputed	T	GEN	443					6.692	0.03523	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs4370878	Imputed	G	DOM	440	1.312	0.1971	0.8916	1.931	1.378	0.1682	0.1648	0.33523	0.36842	0.31	29	82	79	27	101	122
  rs4436200	Imputed	C	ADD	442	0.543	0.2248	0.3494	0.8436	−2.716	0.0066	0.2274	0.13575	0.10209	0.16135	2	35	154	9	63	179
  rs4444612	Imputed	G	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs4444612	Imputed	G	GEN	443					6.692	0.03523	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs4450660	Imputed	C	DOM	438	1.275	0.1965	0.8675	1.874	1.236	0.2163	0.378	0.25457	0.26316	0.24798	11	78	101	21	81	146
  rs4463950	Imputed	C	DOM	438	0.7997	0.211	0.5288	1.209	−1.06	0.2893	0.18	0.46347	0.44415	0.478	41	85	62	60	119	71
  rs4509702	Imputed	C	DOM	440	1.312	0.1971	0.8916	1.931	1.378	0.1682	0.1648	0.33523	0.36842	0.31	29	82	79	27	101	122
  rs4533379	Imputed	G	ADD	441	1.075	0.1633	0.7809	1.481	0.4457	0.6558	0.6902	0.23243	0.23947	0.22709	9	73	108	13	88	150
  rs4569984	Imputed	A	DOM	426	1.031	0.2026	0.6932	1.534	0.1516	0.8795	0.498	0.23357	0.22973	0.23651	10	65	110	16	82	143
  rs4570530	Imputed	C	DOM	440	1.312	0.1971	0.8916	1.931	1.378	0.1682	0.1648	0.33523	0.36842	0.31	29	82	79	27	101	122
  rs4571583	Imputed	T	DOM	439	1.001	0.1996	0.6767	1.48	0.002892	0.9977	0.3419	0.22665	0.22222	0.23	10	64	115	16	83	151
  rs4586678	Imputed	A	DOM	442	1.235	0.1959	0.8415	1.813	1.079	0.2807	0.4569	0.25679	0.26316	0.25198	11	78	101	21	85	146
  rs4615971	Imputed	C	DOM	440	1.347	0.1965	0.9164	1.98	1.516	0.1296	0.2375	0.33182	0.36579	0.306	28	83	79	26	101	123
  rs4629229	Imputed	G	DOM	443	1.138	0.2135	0.7487	1.729	0.6045	0.5455	0.2352	0.16817	0.17801	0.16071	8	52	131	8	65	179
  rs4632512	Imputed	T	GEN	443					1.248	0.5357	0.6275	0.17946	0.19634	0.16667	8	59	124	8	68	176
  rs4641552	Imputed	A	ADD	437	0.6214	0.279	0.3596	1.074	−1.705	0.08817	1	0.07323	0.05585	0.08635	0	21	167	2	39	208
  rs4682527	Imputed	C	DOM	209	2.955	1.237	0.2613	33.41	0.8755	0.3813	1	0.00718	0.01111	0.0042	0	2	88	0	1	118
  rs4688632	Imputed	G	REC	429	0.6822	0.2335	0.4316	1.078	−1.638	0.1014	0.00063	0.45338	0.41892	0.47951	38	79	68	68	98	78
  rs4702720	Imputed	A	ADD	359	0.757	0.1808	0.5311	1.079	−1.54	0.1236	1	0.24652	0.21935	0.26716	10	48	97	12	85	107
  rs4702720	Imputed	A	DOM	359	0.6462	0.2205	0.4194	0.9956	−1.98	0.04769	1	0.24652	0.21935	0.26716	10	48	97	12	85	107
  rs4714484	Imputed	A	ADD	439	0.8396	0.1992	0.5682	1.241	−0.8775	0.3802	0.3702	0.15718	0.1455	0.166	3	49	137	5	73	172
  rs4714484	Imputed	A	DOM	439	0.8278	0.2185	0.5394	1.27	−0.8651	0.387	0.3702	0.15718	0.1455	0.166	3	49	137	5	73	172
  rs4725142	Genotyped	G	REC	443	1.186	0.2801	0.6847	2.053	0.6082	0.5431	0.1412	0.34537	0.35864	0.33532	28	81	82	32	105	115
  rs4725144	Imputed	G	REC	438	1.136	0.2871	0.647	1.994	0.4432	0.6576	0.1657	0.33904	0.3484	0.332	26	79	83	31	104	115
  rs4760785	Imputed	A	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs4760785	Imputed	A	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs4760894	Imputed	T	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs4760894	Imputed	T	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs4760895	Imputed	A	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs4760895	Imputed	A	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs4767184	Imputed	C	ADD	425	0.7759	0.1466	0.5822	1.034	−1.732	0.08334	0.8408	0.40353	0.3674	0.43033	18	97	66	50	110	84
  rs4767184	Imputed	C	GEN	425					8.173	0.0168	0.8408	0.40353	0.3674	0.43033	18	97	66	50	110	84
  rs4773487	Imputed	T	ADD	436	1.73	0.2227	1.118	2.676	2.461	0.01385	0.1754	0.11927	0.14973	0.09639	2	52	133	1	46	202
  rs4780547	Imputed	G	GEN	442					7.627	0.02207	0.3901	0.26244	0.22775	0.28884	7	73	111	27	91	133
  rs4780547	Imputed	G	REC	442	0.2881	0.4519	0.1188	0.6985	−2.754	0.00588	0.3901	0.26244	0.22775	0.28884	7	73	111	27	91	133
  rs483159	Imputed	T	DOM	386	1.953	0.219	1.271	2.999	3.056	0.00225	0.3957	0.18264	0.22561	0.1509	4	66	94	6	55	161
  rs4836502	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs4836507	Imputed	C	DOM	442	0.5803	0.2019	0.3906	0.862	−2.696	0.00703	0.09482	0.34955	0.31414	0.37649	27	66	98	35	119	97
  rs4851531	Imputed	T	DOM	442	0.6071	0.2055	0.4058	0.9082	−2.428	0.01517	0.2107	0.44231	0.40052	0.4741	36	81	74	57	124	70
  rs4879931	Imputed	G	ADD	438	0.7451	0.1533	0.5517	1.006	−1.92	0.05489	0.5791	0.31279	0.28042	0.33735	10	86	93	30	108	111
  rs489441	Imputed	G	ADD	409	1.224	0.1644	0.8866	1.689	1.228	0.2195	0.6152	0.26773	0.28736	0.25319	11	78	85	16	87	132
  rs489441	Imputed	G	DOM	409	1.384	0.2043	0.9276	2.066	1.592	0.1114	0.6152	0.26773	0.28736	0.25319	11	78	85	16	87	132
  rs4976276	Imputed	T	ADD	440	0.9836	0.1502	0.7328	1.32	−0.1103	0.9121	0.5816	0.31591	0.31316	0.318	17	85	88	24	111	115
  rs4977681	Imputed	C	REC	441	0.9851	0.323	0.523	1.856	−0.04633	0.9631	0.7396	0.31293	0.30105	0.322	19	77	95	26	109	115
  rs4986197	Imputed	G	ADD	440	1.083	0.1634	0.7863	1.492	0.4891	0.6248	0.7887	0.23182	0.23947	0.226	9	73	108	13	87	150
  rs4986220	Imputed	T	ADD	442	1.075	0.1653	0.7775	1.486	0.4371	0.6621	1	0.21946	0.22632	0.21429	9	68	113	12	84	156
  rs525462	Imputed	A	GEN	440					8.36	0.0153	0.4957	0.57045	0.53704	0.59562	62	79	48	85	129	37
  rs552006	Imputed	G	GEN	443					0.4432	0.8012	0.8062	0.26298	0.26178	0.26389	11	78	102	18	97	137
  rs5756669	Imputed	C	DOM	443	1.061	0.217	0.6932	1.623	0.2716	0.7859	0.08691	0.48646	0.50262	0.47421	54	84	53	60	119	73
  rs581905	Imputed	T	DOM	442	2.177	0.2555	1.32	3.593	3.045	0.00232	1	0.09955	0.13089	0.0757	2	46	143	2	34	215
  rs6033138	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6033138	Imputed	C	GEN	443					6.692	0.03523	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6040619	Imputed	C	ADD	439	1.429	0.1436	1.079	1.894	2.487	0.01287	0.3441	0.34852	0.39628	0.31275	34	81	73	24	109	118
  rs6040619	Imputed	C	GEN	439					7.276	0.02631	0.3441	0.34852	0.39628	0.31275	34	81	73	24	109	118
  rs6040625	Imputed	T	ADD	442	1.414	0.1431	1.068	1.871	2.419	0.01557	0.3449	0.34729	0.39267	0.31275	34	82	75	24	109	118
  rs6040625	Imputed	T	GEN	442					6.967	0.0307	0.3449	0.34729	0.39267	0.31275	34	82	75	24	109	118
  rs6040630	Imputed	A	ADD	441	1.401	0.1436	1.058	1.857	2.349	0.01881	0.2464	0.34467	0.38947	0.31076	34	80	76	24	108	119
  rs6040630	Imputed	A	GEN	441					6.767	0.03392	0.2464	0.34467	0.38947	0.31076	34	80	76	24	108	119
  rs6040633	Imputed	A	ADD	442	1.391	0.1433	1.05	1.842	2.302	0.02133	0.2489	0.34502	0.38947	0.31151	34	80	76	24	109	119
  rs6040633	Imputed	A	GEN	442					6.683	0.03539	0.2489	0.34502	0.38947	0.31151	34	80	76	24	109	119
  rs6040634	Imputed	T	ADD	441	1.404	0.1433	1.06	1.859	2.368	0.01791	0.295	0.34694	0.39211	0.31275	34	81	75	24	109	118
  rs6040634	Imputed	T	GEN	441					6.855	0.03246	0.295	0.34694	0.39211	0.31275	34	81	75	24	109	118
  rs6040636	Imputed	T	ADD	443	1.371	0.1435	1.034	1.816	2.196	0.0281	0.2458	0.34312	0.38482	0.31151	34	79	78	24	109	119
  rs6040636	Imputed	T	GEN	443					6.529	0.03821	0.2458	0.34312	0.38482	0.31151	34	79	78	24	109	119
  rs6040638	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6040638	Imputed	C	GEN	443					6.692	0.03523	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6040644	Imputed	A	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6040644	Imputed	A	GEN	443					6.692	0.03523	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6040667	Imputed	T	ADD	424	1.422	0.1447	1.071	1.888	2.432	0.01502	0.3997	0.35731	0.40385	0.32231	34	79	69	24	108	110
  rs6040667	Imputed	T	GEN	424					7.201	0.02731	0.3997	0.35731	0.40385	0.32231	34	79	69	24	108	110
  rs6040668	Imputed	C	ADD	440	1.398	0.1448	1.053	1.857	2.314	0.02064	0.5278	0.34659	0.38947	0.314	33	82	75	23	111	116
  rs6040668	Imputed	C	GEN	440					6.796	0.03345	0.5278	0.34659	0.38947	0.314	33	82	75	23	111	116
  rs6053005	Imputed	C	DOM	275	0.4506	0.309	0.2459	0.8257	−2.58	0.00989	0.0865	0.56909	0.53361	0.59615	41	45	33	55	76	25
  rs6054405	Imputed	A	REC	443	0.9755	0.2643	0.5811	1.638	−0.09385	0.9252	0.108	0.38036	0.37696	0.38294	31	82	78	41	111	100
  rs6054427	Genotyped	G	GEN	443					0.8477	0.6545	0.1259	0.36907	0.35602	0.37897	29	78	84	39	113	100
  rs6075186	Imputed	G	DOM	443	1.138	0.2135	0.7487	1.729	0.6045	0.5455	0.2352	0.16817	0.17801	0.16071	8	52	131	8	65	179
  rs608278	Imputed	A	ADD	351	1.166	0.1563	0.8582	1.584	0.9815	0.3263	0.7448	0.43305	0.45364	0.4175	31	75	45	33	101	66
  rs6111540	Imputed	A	ADD	380	0.9692	0.145	0.7295	1.288	−0.2155	0.8294	0.1209	0.45921	0.45181	0.46495	35	80	51	53	93	68
  rs6131206	Imputed	C	ADD	424	1.493	0.1554	1.101	2.025	2.581	0.00986	0.2791	0.28066	0.3288	0.24375	23	75	86	15	87	138
  rs6131208	Imputed	T	ADD	440	1.387	0.1445	1.045	1.841	2.263	0.02364	0.2909	0.34091	0.3836	0.30876	33	79	77	23	109	119
  rs6131208	Imputed	T	GEN	440					6.748	0.03426	0.2909	0.34091	0.3836	0.30876	33	79	77	23	109	119
  rs6131919	Imputed	G	DOM	443	1.138	0.2135	0.7487	1.729	0.6045	0.5455	0.2352	0.16817	0.17801	0.16071	8	52	131	8	65	179
  rs6134243	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6134243	Imputed	C	GEN	443					6.692	0.03523	0.2479	0.34424	0.38743	0.31151	34	80	77	24	109	119
  rs6136020	Imputed	A	DOM	441	1.061	0.2134	0.6982	1.612	0.2765	0.7822	0.1646	0.1644	0.17016	0.16	8	49	134	8	64	178
  rs613799	Imputed	C	DOM	420	1.391	0.2013	0.9378	2.065	1.641	0.1008	0.1798	0.32262	0.35912	0.29498	26	78	77	24	93	122
  rs644041	Imputed	G	ADD	402	1.202	0.1659	0.8685	1.664	1.111	0.2667	0.6136	0.27114	0.28947	0.25758	11	77	83	16	87	128
  rs644041	Imputed	G	DOM	402	1.351	0.2068	0.9007	2.026	1.454	0.1459	0.6136	0.27114	0.28947	0.25758	11	77	83	16	87	128
  rs6464377	Imputed	C	DOM	443	1.043	0.2788	0.6037	1.801	0.1498	0.8809	0.4889	0.07223	0.07068	0.07341	0	27	164	3	31	218
  rs6474230	Imputed	T	DOM	443	1.32	0.1941	0.9026	1.931	1.432	0.1521	0.6236	0.26298	0.27487	0.25397	9	87	95	19	90	143
  rs6476565	Imputed	A	DOM	442	1.184	0.2598	0.7118	1.97	0.6512	0.5149	0.7613	0.0871	0.09474	0.08135	2	32	156	2	37	213
  rs6511286	Imputed	T	ADD	442	1.099	0.1394	0.8364	1.444	0.6778	0.4979	0.1082	0.33371	0.34737	0.32341	24	84	82	33	97	122
  rs6541829	Genotyped	C	REC	443	2.003	0.3363	1.036	3.873	2.066	0.03883	0.1994	0.2833	0.2801	0.28571	24	59	108	17	110	125
  rs6544721	Imputed	G	DOM	436	1.236	0.1963	0.8409	1.815	1.077	0.2814	0.454	0.25803	0.26455	0.25304	11	78	100	21	83	143
  rs6544728	Imputed	T	DOM	439	1.333	0.197	0.9058	1.961	1.458	0.1448	0.7087	0.25854	0.26862	0.251	10	81	97	21	84	146
  rs6565910	Imputed	G	DOM	433	1.047	0.1973	0.7112	1.541	0.2331	0.8157	0.7258	0.28753	0.29144	0.28455	15	79	93	19	102	125
  rs6581985	Imputed	G	GEN	408					7.356	0.02528	0.3553	0.31127	0.35714	0.27682	22	81	72	13	103	117
  rs6581985	Imputed	G	REC	408	2.451	0.3667	1.195	5.028	2.445	0.01449	0.3553	0.31127	0.35714	0.27682	22	81	72	13	103	117
  rs6685186	Imputed	T	ADD	426	1.015	0.1482	0.7591	1.357	0.1003	0.9201	0.3984	0.35329	0.35519	0.35185	23	84	76	26	119	98
  rs6685186	Imputed	T	GEN	426					0.5003	0.7787	0.3984	0.35329	0.35519	0.35185	23	84	76	26	119	98
  rs670593	Imputed	A	REC	442	0.3987	0.3133	0.2158	0.7367	−2.935	0.00333	0.7665	0.40045	0.38158	0.41468	19	107	64	50	109	93
  rs6722640	Imputed	T	DOM	441	0.5987	0.207	0.399	0.8983	−2.478	0.01322	0.2486	0.44671	0.40576	0.478	37	81	73	57	125	68
  rs6746170	Imputed	A	DOM	442	1.346	0.196	0.9168	1.977	1.517	0.1293	0.8072	0.26471	0.27749	0.25498	11	84	96	21	86	144
  rs6757316	Imputed	A	GEN	431					3.593	0.1659	0.01072	0.43155	0.45946	0.41057	31	108	46	36	130	80
  rs6805139	Imputed	G	DOM	442	1.417	0.2237	0.9138	2.197	1.557	0.1194	0.00028	0.52941	0.56283	0.50398	67	81	43	76	101	74
  rs6808571	Imputed	G	ADD	440	1.138	0.1981	0.7719	1.678	0.6528	0.5139	1	0.14091	0.15	0.134	5	47	138	3	61	186
  rs6816479	Imputed	A	REC	430	0.7905	0.293	0.4452	1.404	−0.8024	0.4223	0.3984	0.35349	0.32787	0.37247	22	76	85	36	112	99
  rs6865976	Imputed	C	DOM	401	1.085	0.2308	0.69	1.705	0.352	0.7249	0.2704	0.47382	0.48276	0.46696	38	92	44	46	120	61
  rs687047	Imputed	C	ADD	443	0.5642	0.2311	0.3587	0.8876	−2.476	0.01329	0.8186	0.11512	0.08377	0.13889	0	32	159	5	60	187
  rs6871041	Imputed	G	DOM	418	0.6503	0.2006	0.4389	0.9635	−2.145	0.03192	0.6303	0.2823	0.25824	0.30085	16	62	104	15	112	109
  rs688358	Imputed	A	ADD	427	0.5756	0.2319	0.3653	0.9068	−2.382	0.01723	0.8183	0.1171	0.08602	0.14108	0	32	154	5	58	178
  rs6908481	Imputed	C	REC	400	1.391	0.2704	0.8186	2.363	1.22	0.2226	0.7579	0.41875	0.43275	0.4083	35	78	58	37	113	79
  rs6917224	Imputed	A	ADD	441	0.959	0.1367	0.7336	1.254	−0.3058	0.7597	0.1287	0.37642	0.37105	0.38048	33	75	82	37	117	97
  rs6917224	Imputed	A	GEN	441					2.699	0.2593	0.1287	0.37642	0.37105	0.38048	33	75	82	37	117	97
  rs6920677	Imputed	G	DOM	438	0.9579	0.2018	0.645	1.422	−0.2133	0.8311	0.6893	0.39384	0.37831	0.40562	25	93	71	45	112	92
  rs6994498	Imputed	G	DOM	443	1.32	0.1941	0.9026	1.931	1.432	0.1521	0.6236	0.26298	0.27487	0.25397	9	87	95	19	90	143
  rs6998772	Imputed	T	DOM	442	1.182	0.3637	0.5795	2.411	0.4595	0.6459	1	0.04299	0.04712	0.03984	0	18	173	0	20	231
  rs7022281	Imputed	C	ADD	441	0.6915	0.1481	0.5172	0.9244	−2.491	0.01275	0.548	0.38776	0.34392	0.42063	16	98	75	47	118	87
  rs7022281	Imputed	C	GEN	441					9.434	0.00894	0.548	0.38776	0.34392	0.42063	16	98	75	47	118	87
  rs7022281	Imputed	C	REC	441	0.386	0.3115	0.2096	0.7108	−3.056	0.00224	0.548	0.38776	0.34392	0.42063	16	98	75	47	118	87
  rs7043983	Imputed	T	DOM	438	1.147	0.2639	0.6835	1.923	0.5181	0.6044	0.5344	0.08447	0.09043	0.08	2	30	156	2	36	212
  rs7077799	Imputed	A	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129	0.1663	0.33484	0.36911	0.30876	29	83	79	27	101	123
  rs7088947	Imputed	A	ADD	436	0.5704	0.339	0.2936	1.108	−1.656	0.0977	0.6185	0.05161	0.03743	0.06225	0	14	173	0	31	218
  rs7089661	Imputed	C	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129	0.3355	0.33145	0.36649	0.30478	28	84	79	25	103	123
  rs7102072	Imputed	A	DOM	439	0.9567	0.1978	0.6492	1.41	−0.224	0.8228	0.5412	0.26651	0.25926	0.272	10	78	101	18	100	132
  rs710832	Genotyped	A	REC	443	0.4518	0.4871	0.1739	1.174	−1.631	0.1029	0.4404	0.24492	0.21466	0.26786	6	70	115	17	101	134
  rs712531	Imputed	A	DOM	275	2.784	1.233	0.2485	31.19	0.8305	0.4063	1	0.00545	0.00833	0.00323	0	2	118	0	1	154
  rs7129817	Imputed	T	ADD	441	0.9401	0.1475	0.7041	1.255	−0.4191	0.6751	0.4609	0.3424	0.33598	0.34722	20	87	82	28	119	105
  rs7134262	Imputed	T	GEN	438					5.456	0.06536	1	0.3379	0.37632	0.30847	29	85	76	21	111	116
  rs7134262	Imputed	T	REC	438	1.986	0.3091	1.084	3.641	2.22	0.02641	1	0.3379	0.37632	0.30847	29	85	76	21	111	116
  rs7138300	Imputed	C	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs7138300	Imputed	C	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546	0.438	0.4537	0.40541	0.48988	30	90	65	63	116	68
  rs722927	Imputed	G	ADD	435	0.8492	0.2939	0.4774	1.511	−0.5561	0.5782	1	0.06207	0.05645	0.06627	0	21	165	1	31	217
  rs722927	Imputed	G	DOM	435	0.874	0.3014	0.4842	1.578	−0.4468	0.655	1	0.06207	0.05645	0.06627	0	21	165	1	31	217
  rs726424	Genotyped	G	ADD	443	0.7827	0.1433	0.5911	1.037	−1.709	0.08742	0.6906	0.38939	0.35602	0.41468	18	100	73	47	115	90
  rs726424	Genotyped	G	GEN	443					7.021	0.02989	0.6906	0.38939	0.35602	0.41468	18	100	73	47	115	90
  rs7295817	Imputed	C	ADD	424	0.727	0.1447	0.5475	0.9655	−2.203	0.02761	1	0.42807	0.38187	0.46281	23	93	66	55	114	73
  rs7295817	Imputed	C	GEN	424					6.629	0.03635	1	0.42807	0.38187	0.46281	23	93	66	55	114	73
  rs7295817	Imputed	C	REC	424	0.4929	0.2774	0.2862	0.849	−2.55	0.01077	1	0.42807	0.38187	0.46281	23	93	66	55	114	73
  rs7297372	Imputed	A	ADD	435	0.7305	0.1423	0.5526	0.9655	−2.207	0.02734	1	0.55977	0.51862	0.59109	50	95	43	86	120	41
  rs7297372	Imputed	A	GEN	435					4.87	0.08761	1	0.55977	0.51862	0.59109	50	95	43	86	120	41
  rs7298255	Imputed	A	ADD	443	0.7433	0.1356	0.5699	0.9696	−2.188	0.02869	0.2143	0.46163	0.41885	0.49405	34	92	65	67	115	70
  rs7298255	Imputed	A	DOM	443	0.74	0.2089	0.4914	1.114	−1.442	0.1493	0.2143	0.46163	0.41885	0.49405	34	92	65	67	115	70
  rs7305832	Imputed	C	GEN	442					5.607	0.06061	1	0.33597	0.37435	0.30677	29	85	77	21	112	118
  rs7305832	Imputed	C	REC	442	2.008	0.3089	1.096	3.678	2.256	0.02404	1	0.33597	0.37435	0.30677	29	85	77	21	112	118
  rs737542	Imputed	A	REC	425	2.077	0.347	1.052	4.1	2.107	0.03514	0.1461	0.27765	0.27596	0.27893	23	55	105	16	103	123
  rs742827	Imputed	A	ADD	437	1.396	0.145	1.051	1.855	2.3	0.02146	0.4608	0.34668	0.38947	0.31377	33	82	75	23	109	115
  rs742827	Imputed	A	GEN	437					6.499	0.03879	0.4608	0.34668	0.38947	0.31377	33	82	75	23	109	115
  rs7446891	Imputed	G	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs7448641	Imputed	C	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs7448641	Imputed	C	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs7460605	Imputed	G	DOM	412	1.481	0.222	0.9584	2.288	1.769	0.07694	0.1313	0.42961	0.46369	0.40343	33	100	46	35	118	80
  rs7468898	Imputed	T	ADD	426	1.05	0.1419	0.795	1.386	0.3429	0.7317	0.6273	0.47183	0.48077	0.46516	44	87	51	48	131	65
  rs7468898	Imputed	T	GEN	426					1.795	0.4075	0.6273	0.47183	0.48077	0.46516	44	87	51	48	131	65
  rs7501186	Imputed	A	DOM	443	2.011	0.2218	1.302	3.107	3.15	0.00163	0.4471	0.14447	0.17801	0.11905	3	62	126	8	44	200
  rs755117	Imputed	A	DOM	418	0.7161	0.2216	0.4638	1.106	−1.507	0.1319	0.07503	0.16627	0.14641	0.18143	7	39	135	10	66	161
  rs7557560	Imputed	T	GEN	437					3.838	0.1467	0.05904	0.20938	0.20213	0.21486	14	48	126	12	83	154
  rs7557560	Imputed	T	REC	437	1.621	0.4101	0.7258	3.622	1.179	0.2386	0.05904	0.20938	0.20213	0.21486	14	48	126	12	83	154
  rs7562462	Imputed	T	DOM	436	0.6891	0.2101	0.4565	1.04	−1.772	0.07634	0.2049	0.43349	0.40576	0.4551	31	93	67	44	135	66
  rs757173	Genotyped	G	DOM	443	1.033	0.2035	0.6933	1.54	0.1606	0.8724	0.01107	0.37359	0.3822	0.36706	23	100	68	26	133	93
  rs7607447	Imputed	T	REC	410	2.337	0.3138	1.264	4.323	2.706	0.00681	0.3717	0.33049	0.37288	0.29828	30	72	75	19	101	113
  rs7639053	Imputed	A	ADD	443	1.02	0.1656	0.7375	1.411	0.1214	0.9034	0.6744	0.21558	0.21728	0.21429	10	63	118	12	84	156
  rs7648163	Imputed	C	REC	421	0.941	0.3004	0.5223	1.695	−0.2025	0.8396	0.06007	0.32542	0.32222	0.3278	22	72	86	31	96	114
  rs7651273	Imputed	A	GEN	442					1.393	0.4984	0.6226	0.17534	0.19211	0.1627	7	59	124	8	66	178
  rs7653190	Imputed	C	ADD	433	0.9859	0.1679	0.7095	1.37	−0.0846	0.9326	0.569	0.21478	0.21351	0.21573	10	59	116	12	83	153
  rs7653685	Genotyped	C	DOM	443	0.8286	0.2404	0.5173	1.327	−0.7821	0.4342	0.8039	0.10722	0.09686	0.11508	1	35	155	3	52	197
  rs7684899	Imputed	C	DOM	417	0.5176	0.2237	0.3339	0.8024	−2.944	0.00324	0.8637	0.17266	0.13462	0.20213	6	37	139	7	81	147
  rs7701604	Imputed	G	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs7701604	Imputed	G	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs7703676	Imputed	C	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs7703676	Imputed	C	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709	2.36E−05	0.07336	0.0733	0.07341	3	22	166	7	23	222
  rs7711358	Imputed	A	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.00954	0.1134	0.34312	0.3089	0.36905	26	66	99	34	118	100
  rs7713251	Imputed	C	REC	433	1.11	0.3089	0.6058	2.033	0.3374	0.7358	0.08847	0.30485	0.29894	0.30943	22	69	98	26	99	119
  rs7737608	Imputed	G	DOM	399	0.7496	0.2094	0.4973	1.13	−1.376	0.1687	0.912	0.34712	0.32164	0.36623	18	74	79	29	109	90
  rs7755903	Imputed	A	GEN	426					0.886	0.6421	1	0.41197	0.41129	0.4125	29	95	62	43	112	85
  rs7762993	Imputed	A	ADD	431	1.066	0.1948	0.7276	1.561	0.3271	0.7436	0.00187	0.18213	0.18548	0.17959	2	65	119	3	82	160
  rs7762993	Imputed	A	DOM	431	1.079	0.2057	0.7207	1.614	0.3676	0.7132	0.00187	0.18213	0.18548	0.17959	2	65	119	3	82	160
  rs7767265	Imputed	G	DOM	430	1.155	0.1977	0.7839	1.702	0.7283	0.4664	0.0128	0.24419	0.25936	0.23251	9	79	99	7	99	137
  rs7769415	Imputed	C	GEN	433					11.76	0.0028	0.2034	0.34642	0.41176	0.29675	35	84	68	23	100	123
  rs7771264	Imputed	T	DOM	441	1.051	0.1977	0.7133	1.548	0.251	0.8018	0.25	0.2483	0.25132	0.24603	14	67	108	18	88	146
  rs7795792	Imputed	T	REC	440	0.659	0.2526	0.4017	1.081	−1.651	0.09871	0.3808	0.42727	0.39005	0.45582	30	89	72	55	117	77
  rs7806481	Imputed	G	REC	443	1.465	0.2335	0.9272	2.316	1.636	0.1017	1	0.47517	0.47906	0.47222	50	83	58	50	138	64
  rs7808536	Imputed	G	DOM	409	1.374	0.2138	0.904	2.09	1.488	0.1368	0.7448	0.18582	0.2095	0.16739	8	59	112	7	63	160
  rs7814819	Imputed	G	ADD	250	2.296	0.3362	1.188	4.438	2.472	0.01342	1	0.088	0.12736	0.05903	1	25	80	1	15	128
  rs7814819	Imputed	G	DOM	250	2.549	0.3553	1.271	5.115	2.634	0.00844	1	0.088	0.12736	0.05903	1	25	80	1	15	128
  rs7815952	Imputed	T	DOM	442	1.182	0.3637	0.5795	2.411	0.4595	0.6459	1	0.04299	0.04712	0.03984	0	18	173	0	20	231
  rs7834090	Imputed	T	DOM	442	1.182	0.3637	0.5795	2.411	0.4595	0.6459	1	0.04299	0.04712	0.03984	0	18	173	0	20	231
  rs7859250	Imputed	C	DOM	442	1.184	0.2598	0.7118	1.97	0.6512	0.5149	0.7613	0.0871	0.09474	0.08135	2	32	156	2	37	213
  rs7863577	Genotyped	A	ADD	443	1.029	0.2235	0.6639	1.595	0.1275	0.8986	0.01049	0.10835	0.10995	0.10714	6	30	155	5	44	203
  rs7863577	Genotyped	A	DOM	443	0.9475	0.2573	0.5723	1.569	−0.2095	0.8341	0.01049	0.10835	0.10995	0.10714	6	30	155	5	44	203
  rs7902140	Imputed	C	ADD	442	0.9423	0.1886	0.6511	1.364	−0.3154	0.7525	0.2408	0.16968	0.16492	0.17331	5	53	133	4	79	168
  rs7921834	Imputed	C	DOM	440	1.347	0.1965	0.9164	1.98	1.516	0.1296	0.2375	0.33182	0.36579	0.306	28	83	79	26	101	123
  rs7939893	Imputed	C	ADD	441	0.6916	0.1478	0.5177	0.924	−2.495	0.01261	0.3875	0.32653	0.27895	0.36255	22	62	106	29	124	98
  rs7939893	Imputed	C	DOM	441	0.506	0.1982	0.3431	0.7463	−3.437	0.00059	0.3875	0.32653	0.27895	0.36255	22	62	106	29	124	98
  rs7955901	Imputed	C	ADD	440	0.7285	0.1367	0.5573	0.9524	−2.316	0.02054	0.2142	0.46364	0.41842	0.498	34	91	65	67	115	68
  rs7955901	Imputed	C	DOM	440	0.7139	0.2105	0.4726	1.078	−1.601	0.1093	0.2142	0.46364	0.41842	0.498	34	91	65	67	115	68
  rs7956274	Imputed	T	ADD	426	0.7156	0.1398	0.5441	0.9412	−2.394	0.01667	0.3288	0.45423	0.40659	0.48975	30	88	64	63	113	68
  rs7956274	Imputed	T	DOM	426	0.7031	0.2129	0.4633	1.067	−1.655	0.098	0.3288	0.45423	0.40659	0.48975	30	88	64	63	113	68
  rs7957932	Imputed	G	ADD	439	0.7234	0.1368	0.5533	0.9459	−2.366	0.01797	0.3884	0.47039	0.42408	0.50605	35	92	64	67	117	64
  rs7957932	Imputed	G	DOM	439	0.6888	0.212	0.4546	1.044	−1.758	0.07871	0.3884	0.47039	0.42408	0.50605	35	92	64	67	117	64
  rs7984294	Imputed	A	DOM	437	2.115	0.2464	1.305	3.429	3.041	0.00236	0.6016	0.10069	0.13564	0.0743	2	47	139	1	35	213
  rs7994286	Imputed	A	ADD	436	1.764	0.2224	1.141	2.727	2.552	0.0107	0.1747	0.12041	0.15241	0.09639	2	53	132	1	46	202
  rs7994286	Imputed	A	DOM	436	1.796	0.2315	1.141	2.828	2.529	0.01143	0.1747	0.12041	0.15241	0.09639	2	53	132	1	46	202
  rs8038229	Genotyped	A	ADD	443	0.6909	0.1538	0.5111	0.934	−2.404	0.01622	0.8204	0.29684	0.25393	0.32937	12	73	106	28	110	114
  rs8038229	Genotyped	A	DOM	443	0.666	0.1948	0.4546	0.9756	−2.087	0.03693	0.8204	0.29684	0.25393	0.32937	12	73	106	28	110	114
  rs8043336	Imputed	C	GEN	418					0.2115	0.8997	0.4595	0.36124	0.35955	0.3625	23	82	73	35	104	101
  rs8043336	Imputed	C	REC	418	0.9456	0.301	0.5242	1.706	−0.186	0.8525	0.4595	0.36124	0.35955	0.3625	23	82	73	35	104	101
  rs8054431	Imputed	T	DOM	399	1.148	0.2121	0.7573	1.739	0.6492	0.5162	0.01816	0.36842	0.37791	0.36123	19	92	61	24	116	87
  rs8066502	Imputed	T	DOM	442	0.5122	0.2187	0.3337	0.7864	−3.059	0.00222	0.7257	0.16176	0.1178	0.19522	2	41	148	8	82	161
  rs8068714	Imputed	T	DOM	442	0.5127	0.2187	0.334	0.7871	−3.055	0.00225	0.8632	0.16403	0.11842	0.19841	2	41	147	9	82	161
  rs892575	Imputed	T	ADD	442	1.044	0.1635	0.7579	1.439	0.2645	0.7914	1	0.22624	0.23037	0.22311	9	70	112	13	86	152
  rs892583	Imputed	G	ADD	438	1.079	0.1657	0.7796	1.492	0.457	0.6477	1	0.22146	0.22872	0.216	9	68	111	12	84	154
  rs915494	Imputed	A	ADD	422	1.399	0.1473	1.048	1.868	2.281	0.02256	0.1185	0.32227	0.36828	0.28602	29	79	78	22	91	123
  rs915494	Imputed	A	DOM	422	1.486	0.1999	1.004	2.199	1.982	0.0475	0.1185	0.32227	0.36828	0.28602	29	79	78	22	91	123
  rs917295	Imputed	G	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs922594	Imputed	T	DOM	443	0.5826	0.1985	0.3948	0.8597	−2.722	0.0065	0.6802	0.36005	0.31675	0.39286	21	79	91	34	130	88
  rs9301653	Imputed	T	ADD	438	1.725	0.2225	1.115	2.668	2.451	0.01426	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs9301653	Imputed	T	DOM	438	1.754	0.2318	1.113	2.762	2.423	0.01539	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs9309988	Imputed	G	DOM	443	0.8286	0.2404	0.5173	1.327	−0.7821	0.4342	0.8039	0.10722	0.09686	0.11508	1	35	155	3	52	197
  rs9309989	Genotyped	C	DOM	443	0.771	0.2394	0.4822	1.233	−1.086	0.2774	1	0.11174	0.09686	0.12302	1	35	155	4	54	194
  rs9310221	Imputed	A	DOM	393	0.8966	0.2237	0.5784	1.39	−0.4881	0.6255	0.1503	0.42875	0.42604	0.4308	29	86	54	36	121	67
  rs9327555	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.00964	0.1134	0.34312	0.31152	0.36706	27	65	99	33	119	100
  rs937890	Imputed	G	DOM	442	0.5127	0.2187	0.334	0.7871	−3.055	0.00225	0.8632	0.16403	0.11842	0.19841	2	41	147	9	82	161
  rs9454967	Imputed	G	ADD	441	0.982	0.2314	0.624	1.545	−0.07863	0.9373	0.07328	0.0907	0.08947	0.09163	3	28	159	4	38	209
  rs9454967	Imputed	G	DOM	441	0.9744	0.2621	0.583	1.629	−0.09893	0.9212	0.07328	0.0907	0.08947	0.09163	3	28	159	4	38	209
  rs9471295	Imputed	T	DOM	443	1.784	0.2155	1.169	2.721	2.686	0.00722	0.7052	0.14786	0.18586	0.11905	5	61	125	3	54	195
  rs9477007	Imputed	A	ADD	436	1.012	0.1389	0.7712	1.329	0.08887	0.9292	0.4209	0.39106	0.39362	0.38911	34	80	74	37	119	92
  rs9477007	Imputed	A	GEN	436					1.863	0.394	0.4209	0.39106	0.39362	0.38911	34	80	74	37	119	92
  rs9487279	Imputed	T	DOM	420	1.094	0.2113	0.7229	1.655	0.4244	0.6713	0.4873	0.42976	0.41892	0.4383	29	97	59	52	102	81
  rs949016	Imputed	C	ADD	441	1.063	0.1656	0.7682	1.47	0.3676	0.7132	1	0.21882	0.22487	0.21429	9	67	113	12	84	156
  rs9555973	Imputed	G	ADD	437	1.732	0.2221	1.12	2.676	2.472	0.01343	0.1748	0.12014	0.15079	0.09677	2	53	134	1	46	201
  rs9555973	Imputed	G	DOM	437	1.761	0.2314	1.119	2.772	2.446	0.01443	0.1748	0.12014	0.15079	0.09677	2	53	134	1	46	201
  rs9557510	Imputed	G	ADD	443	1.342	0.1885	0.9272	1.941	1.559	0.119	0.08093	0.14447	0.16754	0.12698	9	46	136	5	54	193
  rs9557510	Imputed	G	DOM	443	1.316	0.2241	0.848	2.042	1.224	0.2208	0.08093	0.14447	0.16754	0.12698	9	46	136	5	54	193
  rs9560584	Imputed	T	DOM	435	1.792	0.2322	1.137	2.824	2.512	0.01202	0.1752	0.11954	0.15135	0.096	2	52	131	1	46	203
  rs9588770	Imputed	T	DOM	443	1.714	0.2282	1.096	2.68	2.36	0.01827	0.8302	0.12754	0.15707	0.10516	3	54	134	3	47	202
  rs9588848	Imputed	C	ADD	438	1.725	0.2225	1.115	2.668	2.451	0.01426	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs9588848	Imputed	C	DOM	438	1.754	0.2318	1.113	2.762	2.423	0.01539	0.1759	0.11872	0.14894	0.096	2	52	134	1	46	203
  rs966583	Imputed	A	ADD	439	0.7596	0.1431	0.5738	1.005	−1.922	0.05464	1	0.40091	0.36579	0.42771	26	87	77	44	125	80
  rs966583	Imputed	A	DOM	439	0.6781	0.203	0.4555	1.01	−1.913	0.0557	1	0.40091	0.36579	0.42771	26	87	77	44	125	80
  rs974130	Genotyped	A	REC	443	0.8861	0.2801	0.5118	1.534	−0.4317	0.6659	0.4714	0.3623	0.34293	0.37698	25	81	85	37	116	99
  rs977160	Imputed	T	ADD	438	0.9972	0.168	0.7174	1.386	−0.0169	0.9865	0.8862	0.21119	0.21011	0.212	9	61	118	11	84	155
  rs9812206	Imputed	G	ADD	442	1.042	0.2668	0.6177	1.758	0.1545	0.8772	0.09556	0.07692	0.07853	0.0757	0	30	161	0	38	213
  rs9812206	Imputed	G	DOM	442	1.042	0.2668	0.6177	1.758	0.1545	0.8772	0.09556	0.07692	0.07853	0.0757	0	30	161	0	38	213
  rs9813552	Imputed	G	ADD	442	1.042	0.2623	0.6235	1.743	0.1586	0.874	0.4984	0.07692	0.07853	0.0757	0	30	161	1	36	214
  rs9813552	Imputed	G	DOM	442	1.077	0.2681	0.6368	1.821	0.2766	0.7821	0.4984	0.07692	0.07853	0.0757	0	30	161	1	36	214
  rs9815037	Imputed	T	ADD	443	1.048	0.2622	0.6267	1.752	0.1778	0.8589	0.4982	0.07675	0.07853	0.0754	0	30	161	1	36	215
  rs9815037	Imputed	T	DOM	443	1.083	0.2681	0.6401	1.831	0.2958	0.7674	0.4982	0.07675	0.07853	0.0754	0	30	161	1	36	215
  rs9825349	Imputed	A	ADD	443	1.048	0.2622	0.6267	1.752	0.1778	0.8589	0.4982	0.07675	0.07853	0.0754	0	30	161	1	36	215
  rs9825349	Imputed	A	DOM	443	1.083	0.2681	0.6401	1.831	0.2958	0.7674	0.4982	0.07675	0.07853	0.0754	0	30	161	1	36	215
  rs9834217	Imputed	T	ADD	443	1.017	0.2611	0.6096	1.696	0.06425	0.9488	0.5011	0.07788	0.07853	0.07738	0	30	161	1	37	214
  rs9834217	Imputed	T	DOM	443	1.049	0.2668	0.6218	1.77	0.179	0.858	0.5011	0.07788	0.07853	0.07738	0	30	161	1	37	214
  rs9840460	Imputed	T	ADD	443	1.017	0.2611	0.6096	1.696	0.06425	0.9488	0.5011	0.07788	0.07853	0.07738	0	30	161	1	37	214
  rs9840460	Imputed	T	DOM	443	1.049	0.2668	0.6218	1.77	0.179	0.858	0.5011	0.07788	0.07853	0.07738	0	30	161	1	37	214
  rs9840756	Imputed	A	ADD	437	0.9995	0.2614	0.5988	1.668	−0.00192	0.9985	0.5026	0.07895	0.07895	0.07895	0	30	160	1	37	209
  rs9840756	Imputed	A	DOM	437	1.031	0.2671	0.6105	1.74	0.1127	0.9103	0.5026	0.07895	0.07895	0.07895	0	30	160	1	37	209
  rs9844801	Imputed	C	DOM	443	0.8286	0.2404	0.5173	1.327	−0.7821	0.4342	0.8039	0.10722	0.09686	0.11508	1	35	155	3	52	197
  rs985375	Imputed	A	GEN	423					0.2263	0.893	0.8976	0.25296	0.25137	0.25417	12	68	103	14	94	132
  rs9869187	Imputed	C	ADD	442	1.037	0.2669	0.6147	1.75	0.1366	0.8914	0.09536	0.07805	0.07895	0.07738	0	30	160	0	39	213
  rs9869187	Imputed	C	DOM	442	1.037	0.2669	0.6147	1.75	0.1366	0.8914	0.09536	0.07805	0.07895	0.07738	0	30	160	0	39	213
  rs9872327	Imputed	T	DOM	443	0.8286	0.2404	0.5173	1.327	−0.7821	0.4342	0.8039	0.10722	0.09686	0.11508	1	35	155	3	52	197
  rs9881685	Imputed	A	ADD	440	1.041	0.2668	0.6172	1.756	0.151	0.88	0.09541	0.07727	0.07895	0.076	0	30	160	0	38	212
  rs9881685	Imputed	A	DOM	440	1.041	0.2668	0.6172	1.756	0.151	0.88	0.09541	0.07727	0.07895	0.076	0	30	160	0	38	212
  rs9909499	Imputed	C	DOM	422	1.716	0.1997	1.161	2.539	2.706	0.00681	0.6472	0.3045	0.33516	0.28125	15	92	75	26	83	131
  rs9911847	Imputed	G	DOM	442	0.5127	0.2187	0.334	0.7871	−3.055	0.00225	0.8632	0.16403	0.11842	0.19841	2	41	147	9	82	161
  rs9958823	Imputed	A	ADD	438	1.083	0.1637	0.7858	1.493	0.4879	0.6256	0.7885	0.23174	0.23947	0.22581	9	73	108	13	86	149
  rs9965248	Imputed	T	ADD	437	1.002	0.1681	0.721	1.394	0.01427	0.9886	0.8864	0.21167	0.21123	0.212	9	61	117	11	84	155

• TABLE 12
  		ALLELE
  SNP rs #	SOURCE	(A1)	MODEL	P	P(R)	OR	OR(R)	Q	I

  rs198460	Genotyped	G	RECESSIVE	2.29E−04	0.000229	1.7469	1.7469	0.3205	0
  rs603940	Genotyped	G	RECESSIVE	4.77E−03	0.004769	0.6036	0.6036	0.9004	0
  rs10021016	Genotyped	G	GENOTYPIC	1.53E−03	0.001532	2.2715	2.2715	0.7583	0
  rs1003148	Imputed	C	ADDITIVE	1.09E−04	0.0001087	0.706	0.706	0.7408	0
  rs1003148	Imputed	C	GENOTYPIC	0.0001585	0.0001585	0.4899	0.4899	0.518	0
  rs1003148	Imputed	C	RECESSIVE	0.001753	0.00218	0.5819	0.5829	0.3099	3.02
  rs10046799	Imputed	C	ADDITIVE	3.21E−04	0.003933	0.724	0.7134	0.2084	36.82
  rs10046799	Imputed	C	GENOTYPIC	0.0005855	0.003461	0.5342	0.5221	0.2386	28.01
  rs10051148	Imputed	C	DOMINANT	1.63E−05	1.63E−05	0.5783	0.5783	0.7565	0
  rs10054055	Imputed	T	DOMINANT	1.71E−05	1.71E−05	0.5791	0.5791	0.7456	0
  rs10067895	Imputed	A	DOMINANT	1.57E−05	1.57E−05	0.5759	0.5759	0.7904	0
  rs1008705	Imputed	C	DOMINANT	8.42E−03	0.00842	1.4761	1.4761	0.9317	0
  rs10105871	Imputed	C	DOMINANT	5.40E−04	0.0005398	1.6092	1.6092	0.4959	0
  rs10116807	Imputed	A	GENOTYPIC	4.73E−04	0.0004726	3.0952	3.0952	0.9876	0
  rs10116807	Imputed	A	RECESSIVE	5.24E−04	5.24E−04	3.0277	3.0277	0.956	0
  rs10121941	Imputed	C	DOMINANT	7.75E−05	7.75E−05	0.5093	0.5093	0.7525	0
  rs10128638	Genotyped	G	DOMINANT	3.84E−04	0.0003837	0.6023	0.6023	0.6707	0
  rs1012924	Imputed	G	ADDITIVE	6.55E−05	6.55E−05	0.5369	0.5369	0.7455	0
  rs1012924	Imputed	G	DOMINANT	4.31E−05	4.31E−05	0.5009	0.5009	0.6615	0
  rs1016030	Genotyped	G	ADDITIVE	7.02E−05	7.02E−05	1.4487	1.4487	0.5994	0
  rs1016030	Genotyped	G	GENOTYPIC	8.31E−05	8.31E−05	2.1351	2.1351	0.6388	0
  rs1017558	Imputed	A	RECESSIVE	9.48E−05	9.48E−05	2.016	2.016	0.6946	0
  rs10183431	Imputed	T	DOMINANT	9.50E−05	9.50E−05	1.6438	1.6438	0.7949	0
  rs10195401	Imputed	C	DOMINANT	8.08E−05	8.08E−05	1.679	1.679	0.7757	0
  rs10239416	Imputed	A	DOMINANT	5.37E−05	5.37E−05	0.5939	0.5939	0.6861	0
  rs1032188	Imputed	G	GENOTYPIC	0.0003684	0.004755	0.411	0.3885	0.2102	36.31
  rs1032188	Imputed	G	RECESSIVE	0.0009593	0.01499	0.4495	0.4153	0.1711	46.62
  rs10468988	Imputed	G	ADDITIVE	2.45E−05	2.45E−05	1.5305	1.5305	0.6802	0
  rs10478919	Imputed	G	DOMINANT	1.10E−05	1.10E−05	0.5722	0.5722	0.6924	0
  rs10506623	Imputed	C	DOMINANT	1.26E−04	0.0001255	0.6039	0.6039	0.8321	0
  rs10506626	Imputed	A	DOMINANT	2.45E−05	2.45E−05	0.5722	0.5722	0.8985	0
  rs10509477	Imputed	T	DOMINANT	1.46E−04	0.000146	1.6135	1.6135	0.3224	0
  rs10511071	Imputed	C	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs10511072	Imputed	G	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs10511199	Imputed	C	ADDITIVE	9.67E−05	9.67E−05	1.5246	1.5246	0.8383	0
  rs10513283	Imputed	G	GENOTYPIC	8.48E−05	8.48E−05	3.6142	3.6142	0.3734	0
  rs10520072	Imputed	T	DOMINANT	1.41E−05	1.41E−05	0.5759	0.5759	0.7897	0
  rs1065639	Imputed	C	DOMINANT	6.94E−05	6.94E−05	1.7059	1.7059	0.8002	0
  rs10733846	Imputed	G	ADDITIVE	8.04E−06	8.04E−06	0.5881	0.5881	0.4857	0
  rs10733846	Imputed	G	DOMINANT	7.17E−05	7.17E−05	0.5809	0.5809	0.6915	0
  rs10737390	Imputed	T	DOMINANT	5.78E−05	5.78E−05	0.5929	0.5929	0.5632	0
  rs10749293	Imputed	G	DOMINANT	9.87E−05	0.0001063	1.6321	1.6316	0.3156	0.71
  rs10752159	Imputed	G	DOMINANT	0.0003712	0.001012	1.5856	1.5961	0.2786	14.82
  rs10753760	Imputed	T	ADDITIVE	9.28E−05	9.28E−05	1.4355	1.4355	0.8085	0
  rs10753760	Imputed	T	GENOTYPIC	8.65E−05	8.65E−05	2.1142	2.1142	0.8438	0
  rs10757887	Imputed	C	DOMINANT	8.87E−05	8.87E−05	0.604	0.604	0.8342	0
  rs10758326	Imputed	A	ADDITIVE	8.55E−04	0.0008545	0.7335	0.7335	0.95	0
  rs10758326	Imputed	A	GENOTYPIC	0.001038	0.001038	0.5194	0.5194	0.7462	0
  rs10758326	Imputed	A	RECESSIVE	6.13E−03	0.006132	0.603	0.603	0.5469	0
  rs10762236	Genotyped	G	ADDITIVE	2.14E−05	2.14E−05	0.6093	0.6093	0.584	0
  rs10765769	Imputed	C	ADDITIVE	2.91E−05	2.91E−05	1.474	1.474	0.756	0
  rs10765769	Imputed	C	GENOTYPIC	5.17E−05	5.17E−05	2.1499	2.1499	0.7054	0
  rs10784891	Imputed	C	ADDITIVE	0.0003093	0.0003093	0.711	0.711	0.6979	0
  rs10784891	Imputed	C	DOMINANT	5.54E−05	5.54E−05	0.5722	0.5722	0.9756	0
  rs10787923	Imputed	G	DOMINANT	6.47E−05	1.80E−04	1.6581	1.6522	0.2931	9.54
  rs10787949	Imputed	A	DOMINANT	1.77E−04	0.001337	1.6068	1.5927	0.2585	21.69
  rs10787951	Imputed	G	DOMINANT	0.0001766	0.001337	1.6068	1.5927	0.2585	21.69
  rs10787983	Imputed	C	DOMINANT	1.40E−04	0.0004442	1.6153	1.6079	0.2874	11.66
  rs10788380	Imputed	C	ADDITIVE	0.0005839	0.0005839	1.3678	1.3678	0.66	0
  rs10788380	Imputed	C	DOMINANT	4.48E−04	4.48E−04	1.7138	1.7138	0.8013	0
  rs10788380	Imputed	C	GENOTYPIC	0.0004936	0.0004936	1.8999	1.8999	0.7216	0
  rs10814418	Imputed	G	DOMINANT	8.78E−05	8.78E−05	0.5119	0.5119	0.7369	0
  rs10831417	Imputed	A	ADDITIVE	1.96E−05	1.96E−05	1.4929	1.4929	0.5559	0
  rs10831417	Imputed	A	GENOTYPIC	1.73E−05	1.73E−05	2.3097	2.3097	0.6056	0
  rs10831422	Imputed	C	ADDITIVE	5.92E−05	5.92E−05	1.4561	1.4561	0.7103	0
  rs10831422	Imputed	C	GENOTYPIC	4.43E−05	4.43E−05	2.2133	2.2133	0.7026	0
  rs10862931	Imputed	C	GENOTYPIC	9.68E−05	9.68E−05	0.4267	0.4267	0.4634	0
  rs10865197	Imputed	C	DOMINANT	9.34E−05	9.34E−05	1.6437	1.6437	0.7947	0
  rs10871302	Imputed	A	DOMINANT	0.009612	0.009612	1.4552	1.4552	0.5024	0
  rs10877463	Imputed	C	DOMINANT	2.64E−03	0.002642	0.6825	0.6825	0.4291	0
  rs10877468	Imputed	C	DOMINANT	2.82E−03	0.002816	0.6833	0.6833	0.3554	0
  rs10879240	Imputed	C	ADDITIVE	5.13E−04	0.001027	0.6811	0.6808	0.2896	10.85
  rs10879242	Imputed	A	DOMINANT	2.95E−05	2.95E−05	0.5555	0.5555	0.3862	0
  rs10879245	Imputed	G	DOMINANT	2.95E−05	2.95E−05	0.5555	0.5555	0.3862	0
  rs10879249	Imputed	T	DOMINANT	1.19E−04	0.0001194	0.6021	0.6021	0.7426	0
  rs10886452	Imputed	A	DOMINANT	1.77E−04	0.001337	1.6068	1.5927	0.2585	21.69
  rs10886463	Imputed	C	DOMINANT	1.54E−04	6.44E−04	1.6141	1.6047	0.2786	14.82
  rs10886465	Imputed	A	DOMINANT	0.00019	0.0006506	1.604	1.596	0.2834	13.1
  rs10886526	Imputed	C	DOMINANT	1.74E−04	0.0001743	1.6053	1.6053	0.3255	0
  rs10902437	Imputed	G	ADDITIVE	1.74E−03	1.74E−03	1.3336	1.3336	0.3478	0
  rs10941126	Imputed	G	ADDITIVE	2.13E−05	2.13E−05	0.1976	0.1976	0.798	0
  rs10941126	Imputed	G	DOMINANT	3.85E−05	3.85E−05	0.2007	0.2007	0.8145	0
  rs10947871	Imputed	A	DOMINANT	2.08E−03	0.002076	1.5391	1.5391	0.8556	0
  rs10972978	Imputed	G	DOMINANT	6.77E−05	6.77E−05	0.5018	0.5018	0.7975	0
  rs10973012	Imputed	A	DOMINANT	7.75E−05	7.75E−05	0.5093	0.5093	0.7525	0
  rs10974028	Genotyped	G	ADDITIVE	9.41E−05	9.41E−05	0.6153	0.6153	0.8548	0
  rs10974028	Genotyped	G	DOMINANT	1.15E−05	1.15E−05	0.5349	0.5349	0.733	0
  rs11021302	Imputed	A	ADDITIVE	6.97E−05	6.97E−05	1.4505	1.4505	0.6892	0
  rs11021302	Imputed	A	GENOTYPIC	4.72E−05	4.72E−05	2.2069	2.2069	0.695	0
  rs11099644	Imputed	G	RECESSIVE	9.48E−05	9.48E−05	2.016	2.016	0.6946	0
  rs11138315	Imputed	G	ADDITIVE	0.002501	0.002501	0.6333	0.6333	0.4998	0
  rs11149802	Imputed	T	DOMINANT	9.61E−03	0.009612	1.4552	1.4552	0.5024	0
  rs1116596	Imputed	T	DOMINANT	1.10E−05	1.10E−05	0.5722	0.5722	0.6924	0
  rs11178531	Imputed	A	ADDITIVE	0.001066	0.001066	0.7412	0.7412	0.6947	0
  rs11178531	Imputed	A	DOMINANT	5.75E−05	5.75E−05	0.572	0.572	0.8111	0
  rs11178575	Imputed	C	GENOTYPIC	0.002546	0.002546	1.8735	1.8735	0.3907	0
  rs11178575	Imputed	C	RECESSIVE	0.001194	0.001194	1.8848	1.8848	0.3922	0
  rs11178577	Imputed	T	GENOTYPIC	0.002616	0.002616	1.87	1.87	0.3948	0
  rs11178577	Imputed	T	RECESSIVE	0.001154	0.001154	1.8884	1.8884	0.4001	0
  rs11178583	Imputed	A	DOMINANT	7.82E−05	7.82E−05	0.5918	0.5918	0.6676	0
  rs11178589	Imputed	T	DOMINANT	0.0001977	0.0001977	0.6108	0.6108	0.7703	0
  rs11178594	Imputed	C	DOMINANT	8.34E−05	8.34E−05	0.5951	0.5951	0.7778	0
  rs11178602	Imputed	T	DOMINANT	7.78E−05	7.78E−05	0.5942	0.5942	0.6786	0
  rs11178648	Imputed	T	DOMINANT	2.45E−05	2.45E−05	0.576	0.576	0.8248	0
  rs11198877	Imputed	T	DOMINANT	0.0001766	0.001337	1.6068	1.5927	0.2585	21.69
  rs11198942	Imputed	T	DOMINANT	0.0001123	0.0002521	1.6276	1.6227	0.2973	7.94
  rs11221075	Imputed	A	ADDITIVE	0.002456	0.002456	0.6561	0.6561	0.6722	0
  rs11242020	Imputed	T	DOMINANT	8.24E−06	8.24E−06	0.5675	0.5675	0.7214	0
  rs11242021	Imputed	T	DOMINANT	1.39E−05	1.39E−05	0.5753	0.5753	0.7864	0
  rs11242022	Imputed	T	DOMINANT	1.90E−05	1.90E−05	0.5805	0.5805	0.7156	0
  rs11242023	Imputed	T	DOMINANT	1.94E−05	1.94E−05	0.5807	0.5807	0.7577	0
  rs1149350	Imputed	A	DOMINANT	8.78E−05	8.78E−05	1.6713	1.6713	0.3701	0
  rs1150143	Imputed	G	DOMINANT	5.41E−05	5.41E−05	1.6852	1.6852	0.741	0
  rs11576627	Imputed	T	ADDITIVE	2.21E−04	0.0002213	1.6268	1.6268	0.4154	0
  rs11576627	Imputed	T	DOMINANT	0.0002026	0.0002026	1.7055	1.7055	0.4813	0
  rs11602189	Imputed	A	DOMINANT	5.90E−05	5.90E−05	0.6007	0.6007	0.9545	0
  rs11605163	Imputed	A	DOMINANT	6.08E−05	6.08E−05	2.1075	2.1075	0.8875	0
  rs11615214	Imputed	G	ADDITIVE	3.71E−05	3.71E−05	0.6853	0.6853	0.3765	0
  rs11615214	Imputed	G	GENOTYPIC	9.43E−05	0.001874	0.4648	0.4738	0.2292	30.83
  rs11642394	Imputed	C	DOMINANT	0.009359	0.009359	1.4572	1.4572	0.5108	0
  rs11644943	Imputed	A	ADDITIVE	0.001027	0.001027	1.4247	1.4247	0.3922	0
  rs11656608	Imputed	T	DOMINANT	4.43E−03	0.004428	0.6695	0.6695	0.7811	0
  rs11661309	Imputed	A	ADDITIVE	3.52E−05	3.52E−05	0.6163	0.6163	0.8488	0
  rs11661309	Imputed	A	DOMINANT	8.21E−05	8.21E−05	0.5852	0.5852	0.7907	0
  rs11666131	Imputed	A	ADDITIVE	6.47E−05	6.47E−05	1.5364	1.5364	0.8474	0
  rs11743355	Imputed	C	ADDITIVE	2.07E−05	2.07E−05	0.1796	0.1796	0.7144	0
  rs11743355	Imputed	C	DOMINANT	3.53E−05	3.53E−05	0.1817	0.1817	0.7255	0
  rs11746806	Imputed	T	ADDITIVE	3.41E−05	3.41E−05	0.2206	0.2206	0.9267	0
  rs11746806	Imputed	T	DOMINANT	6.55E−05	6.55E−05	0.2253	0.2253	0.9509	0
  rs11746959	Imputed	T	ADDITIVE	2.13E−05	2.13E−05	0.1976	0.1976	0.798	0
  rs11746959	Imputed	T	DOMINANT	3.85E−05	3.85E−05	0.2007	0.2007	0.8145	0
  rs11749272	Imputed	T	DOMINANT	1.23E−05	1.23E−05	0.5734	0.5734	0.7009	0
  rs11901899	Imputed	A	DOMINANT	0.0003007	0.0003007	1.5824	1.5824	0.3922	0
  rs11926319	Imputed	G	ADDITIVE	7.83E−07	7.83E−07	0.4343	0.4343	0.3992	0
  rs11926319	Imputed	G	DOMINANT	1.01E−06	1.01E−06	0.4237	0.4237	0.4489	0
  rs11956952	Imputed	C	DOMINANT	0.0009505	0.0009505	0.6564	0.6564	0.7028	0
  rs12025826	Imputed	G	DOMINANT	0.0005142	0.0005142	1.5794	1.5794	0.3682	0
  rs1204522	Imputed	C	GENOTYPIC	8.61E−05	8.61E−05	0.4353	0.4353	0.6828	0
  rs1204524	Imputed	A	GENOTYPIC	8.54E−05	8.54E−05	0.4351	0.4351	0.6472	0
  rs12153185	Imputed	T	DOMINANT	1.57E−05	1.57E−05	0.5759	0.5759	0.7904	0
  rs12182651	Imputed	T	ADDITIVE	7.03E−06	7.03E−06	2.1926	2.1926	0.7348	0
  rs12182651	Imputed	T	DOMINANT	1.21E−06	1.21E−06	2.4795	2.4795	0.5648	0
  rs12193568	Imputed	G	DOMINANT	0.000391	0.004677	1.7403	1.8042	0.2164	34.55
  rs12264914	Imputed	C	DOMINANT	1.11E−02	0.01109	0.6442	0.6442	0.505	0
  rs12307767	Imputed	C	DOMINANT	0.001811	0.001811	0.6667	0.6667	0.3444	0
  rs1232298	Imputed	G	RECESSIVE	0.0006722	0.006032	2.0566	2.0955	0.2088	36.69
  rs12407412	Imputed	C	ADDITIVE	0.0002213	0.0002213	1.6268	1.6268	0.4154	0
  rs12407412	Imputed	C	DOMINANT	2.03E−04	0.0002026	1.7055	1.7055	0.4813	0
  rs12420184	Imputed	G	DOMINANT	6.39E−05	6.39E−05	0.5645	0.5645	0.7037	0
  rs12422750	Imputed	A	DOMINANT	0.00369	0.00369	0.6919	0.6919	0.3546	0
  rs12446951	Imputed	A	ADDITIVE	6.52E−05	6.52E−05	2.3413	2.3413	0.3314	0
  rs12446951	Imputed	A	DOMINANT	0.0001226	0.0001226	2.3135	2.3135	0.3285	0
  rs12457400	Imputed	G	DOMINANT	0.0009766	0.0009766	0.5884	0.5884	0.6035	0
  rs1247340	Imputed	C	DOMINANT	8.32E−05	8.32E−05	1.6742	1.6742	0.3604	0
  rs1247341	Imputed	C	DOMINANT	7.02E−05	7.02E−05	1.684	1.684	0.3274	0
  rs12521291	Imputed	G	ADDITIVE	6.67E−05	6.67E−05	0.6857	0.6857	0.9769	0
  rs12526849	Imputed	T	ADDITIVE	7.52E−05	7.52E−05	1.4208	1.4208	0.6829	0
  rs12526849	Imputed	T	GENOTYPIC	7.73E−05	7.73E−05	2.0445	2.0445	0.7856	0
  rs12543110	Imputed	G	DOMINANT	0.0001096	0.0001096	1.6401	1.6401	0.5183	0
  rs12678600	Imputed	A	DOMINANT	9.83E−05	9.83E−05	0.6104	0.6104	0.9092	0
  rs12719415	Imputed	T	DOMINANT	8.10E−06	8.10E−06	0.5662	0.5662	0.7128	0
  rs12831292	Imputed	G	DOMINANT	9.77E−05	9.77E−05	0.5982	0.5982	0.6795	0
  rs12923993	Imputed	C	DOMINANT	0.009359	0.009359	1.4572	1.4572	0.5108	0
  rs12936964	Imputed	T	DOMINANT	9.02E−05	9.02E−05	1.6688	1.6688	0.7618	0
  rs12960663	Imputed	G	ADDITIVE	5.61E−05	5.61E−05	0.6241	0.6241	0.7884	0
  rs13038146	Imputed	C	ADDITIVE	0.0005045	0.0005045	1.3708	1.3708	0.7263	0
  rs13038146	Imputed	C	GENOTYPIC	0.0006517	0.0006517	1.9308	1.9308	0.8764	0
  rs13134222	Imputed	A	GENOTYPIC	9.86E−05	9.86E−05	0.3011	0.3011	0.8224	0
  rs13172910	Imputed	A	DOMINANT	0.0008666	0.0008666	0.6547	0.6547	0.7269	0
  rs13194907	Imputed	A	ADDITIVE	1.34E−05	1.34E−05	2.303	2.303	0.9028	0
  rs13194907	Imputed	A	DOMINANT	5.24E−06	5.24E−06	2.505	2.505	0.845	0
  rs13195745	Imputed	A	ADDITIVE	1.34E−05	1.34E−05	2.303	2.303	0.9028	0
  rs13195745	Imputed	A	DOMINANT	5.24E−06	5.24E−06	2.505	2.505	0.845	0
  rs1321432	Imputed	A	RECESSIVE	3.78E−05	3.78E−05	2.1221	2.1221	0.4916	0
  rs1321457	Imputed	G	RECESSIVE	7.32E−05	7.32E−05	2.0656	2.0656	0.4383	0
  rs13265054	Imputed	T	DOMINANT	1.26E−04	0.0001261	0.6144	0.6144	0.8838	0
  rs13282131	Imputed	C	GENOTYPIC	6.83E−04	0.0006831	1.8412	1.8412	0.8885	0
  rs13353526	Imputed	C	DOMINANT	4.66E−05	4.66E−05	1.9371	1.9371	0.4192	0
  rs1336382	Imputed	T	DOMINANT	1.46E−04	1.46E−04	1.6135	1.6135	0.3224	0
  rs1336383	Imputed	T	DOMINANT	0.000146	0.000146	1.6135	1.6135	0.3224	0
  rs1336407	Imputed	T	DOMINANT	0.000146	0.000146	1.6135	1.6135	0.3224	0
  rs1336409	Imputed	T	DOMINANT	1.62E−04	0.0002489	1.6085	1.6059	0.3065	4.35
  rs1336596	Imputed	A	DOMINANT	5.25E−05	5.25E−05	0.5951	0.5951	0.5868	0
  rs1343560	Imputed	T	ADDITIVE	7.42E−05	7.42E−05	0.5393	0.5393	0.7611	0
  rs1343560	Imputed	T	DOMINANT	4.91E−05	4.91E−05	0.5034	0.5034	0.6771	0
  rs1361987	Imputed	T	GENOTYPIC	9.25E−05	9.25E−05	0.4404	0.4404	0.5591	0
  rs1386153	Imputed	T	ADDITIVE	8.36E−05	8.36E−05	0.6841	0.6841	0.8357	0
  rs1386153	Imputed	T	DOMINANT	5.01E−05	5.01E−05	0.599	0.599	0.9393	0
  rs1394015	Imputed	C	DOMINANT	5.43E−05	5.43E−05	1.7294	1.7294	0.6444	0
  rs1407038	Imputed	A	RECESSIVE	5.83E−05	5.83E−05	2.0823	2.0823	0.4381	0
  rs1407039	Imputed	A	RECESSIVE	9.91E−05	9.91E−05	2.0129	2.0129	0.5236	0
  rs1412802	Imputed	T	GENOTYPIC	0.0007205	0.0007205	0.4264	0.4264	0.7234	0
  rs1414865	Imputed	T	DOMINANT	0.0001766	0.001337	1.6068	1.5927	0.2585	21.69
  rs1414873	Imputed	A	DOMINANT	0.000122	0.0001815	1.6219	1.6195	0.3077	3.88
  rs1414876	Imputed	C	DOMINANT	0.000122	0.0001815	1.6219	1.6195	0.3077	3.88
  rs1418671	Imputed	C	RECESSIVE	9.36E−06	9.36E−06	2.1762	2.1762	0.8027	0
  rs1419490	Genotyped	T	GENOTYPIC	8.94E−05	8.94E−05	0.4398	0.4398	0.5307	0
  rs1434507	Imputed	A	ADDITIVE	7.02E−05	7.02E−05	1.4932	1.4932	0.6454	0
  rs1434508	Imputed	T	ADDITIVE	9.01E−05	9.01E−05	1.4841	1.4841	0.6551	0
  rs1435205	Imputed	A	ADDITIVE	9.67E−05	9.67E−05	1.5246	1.5246	0.8383	0
  rs1443928	Imputed	C	RECESSIVE	6.72E−05	6.72E−05	0.5586	0.5586	0.6157	0
  rs1452235	Imputed	G	GENOTYPIC	7.97E−05	7.97E−05	0.4269	0.4269	0.4549	0
  rs1452236	Imputed	G	GENOTYPIC	7.57E−05	7.57E−05	0.4257	0.4257	0.4487	0
  rs1452237	Imputed	G	GENOTYPIC	7.97E−05	7.97E−05	0.4269	0.4269	0.4549	0
  rs1452243	Genotyped	T	GENOTYPIC	7.97E−05	7.97E−05	0.4269	0.4269	0.4549	0
  rs1463768	Genotyped	G	RECESSIVE	4.61E−04	0.01223	1.8009	1.8886	0.1522	51.22
  rs1463769	Imputed	G	RECESSIVE	3.34E−04	0.007743	1.8295	1.9062	0.171	46.65
  rs1472435	Imputed	A	ADDITIVE	0.0002548	0.001662	0.5022	0.4908	0.2466	25.51
  rs1472435	Imputed	A	DOMINANT	5.02E−04	0.004002	0.5076	0.4938	0.2238	32.42
  rs1476714	Imputed	A	DOMINANT	1.19E−05	1.19E−05	0.5726	0.5726	0.7844	0
  rs1495159	Imputed	G	ADDITIVE	1.61E−05	1.61E−05	0.6509	0.6509	0.7963	0
  rs1495159	Imputed	G	GENOTYPIC	7.70E−05	7.70E−05	0.3915	0.3915	0.8463	0
  rs1495375	Imputed	A	DOMINANT	0.0001025	0.0001025	0.5962	0.5962	0.6659	0
  rs1495376	Imputed	T	DOMINANT	2.01E−05	2.01E−05	0.5347	0.5347	0.3504	0
  rs1495377	Imputed	G	DOMINANT	3.97E−05	7.56E−05	0.5484	0.5467	0.2993	7.17
  rs1495381	Imputed	T	GENOTYPIC	0.0009636	0.0009636	1.8616	1.8616	0.5241	0
  rs1495381	Imputed	T	RECESSIVE	0.0001018	0.0001018	1.9326	1.9326	0.6962	0
  rs1498992	Imputed	G	DOMINANT	1.48E−04	0.0001483	0.6213	0.6213	0.4944	0
  rs1499001	Imputed	T	DOMINANT	0.0001967	0.0001967	0.6214	0.6214	0.5607	0
  rs1512988	Imputed	A	DOMINANT	9.29E−05	9.29E−05	0.5976	0.5976	0.8745	0
  rs1512989	Imputed	T	DOMINANT	9.29E−05	9.29E−05	0.5976	0.5976	0.8745	0
  rs1512991	Imputed	T	ADDITIVE	1.02E−03	0.001016	0.7391	0.7391	0.9158	0
  rs1512991	Imputed	T	DOMINANT	8.22E−05	8.22E−05	0.5816	0.5816	0.9166	0
  rs1516855	Imputed	G	RECESSIVE	7.25E−05	7.25E−05	2.1755	2.1755	0.4759	0
  rs1527450	Imputed	T	ADDITIVE	2.46E−05	2.46E−05	1.486	1.486	0.5328	0
  rs1527450	Imputed	T	GENOTYPIC	2.19E−05	2.19E−05	2.2868	2.2868	0.5806	0
  rs1567740	Imputed	T	DOMINANT	8.80E−05	8.80E−05	0.596	0.596	0.8322	0
  rs1572573	Imputed	A	ADDITIVE	2.45E−05	2.45E−05	1.6309	1.6309	0.4087	0
  rs1572573	Imputed	A	DOMINANT	4.83E−06	4.83E−06	1.8564	1.8564	0.424	0
  rs1584003	Imputed	C	DOMINANT	3.11E−05	3.11E−05	1.8445	1.8445	0.5284	0
  rs1584005	Imputed	C	DOMINANT	4.62E−05	4.62E−05	1.8227	1.8227	0.5661	0
  rs1585771	Imputed	G	ADDITIVE	8.69E−05	8.69E−05	1.4824	1.4824	0.9898	0
  rs1592015	Imputed	G	DOMINANT	6.94E−05	6.94E−05	0.5728	0.5728	0.3692	0
  rs1594885	Imputed	A	ADDITIVE	3.75E−05	3.75E−05	1.5121	1.5121	0.6724	0
  rs1603232	Imputed	A	DOMINANT	8.75E−05	8.75E−05	0.5656	0.5656	0.3264	0
  rs1614565	Imputed	C	DOMINANT	1.53E−05	1.53E−05	0.5357	0.5357	0.5207	0
  rs1648200	Imputed	G	ADDITIVE	0.0002847	0.0002847	1.4867	1.4867	0.9072	0
  rs16877387	Imputed	C	GENOTYPIC	6.36E−05	6.36E−05	2.2411	2.2411	0.7064	0
  rs16877387	Imputed	C	RECESSIVE	2.50E−05	2.50E−05	2.2227	2.2227	0.938	0
  rs16938626	Imputed	G	DOMINANT	1.07E−04	0.0001071	0.6116	0.6116	0.7404	0
  rs1694334	Imputed	G	ADDITIVE	8.91E−05	8.91E−05	0.6436	0.6436	0.6943	0
  rs16998821	Imputed	C	DOMINANT	6.94E−05	6.94E−05	0.5728	0.5728	0.3692	0
  rs1700400	Imputed	T	ADDITIVE	4.31E−05	4.31E−05	0.6508	0.6508	0.3976	0
  rs17007620	Imputed	G	ADDITIVE	2.46E−05	2.46E−05	1.6003	1.6003	0.8148	0
  rs17007620	Imputed	G	DOMINANT	3.02E−05	3.02E−05	1.7521	1.7521	0.9606	0
  rs17023290	Imputed	C	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs17047957	Imputed	C	DOMINANT	0.001192	0.001192	1.5648	1.5648	0.6233	0
  rs1705237	Imputed	A	DOMINANT	1.05E−05	1.05E−05	0.5283	0.5283	0.5228	0
  rs1705261	Imputed	A	GENOTYPIC	0.0008093	0.0008093	1.8782	1.8782	0.4997	0
  rs1705261	Imputed	A	RECESSIVE	0.0001018	0.0001018	1.9326	1.9326	0.6962	0
  rs17076972	Imputed	C	ADDITIVE	6.68E−05	6.68E−05	1.4316	1.4316	0.9615	0
  rs17076972	Imputed	C	GENOTYPIC	4.84E−05	4.84E−05	2.0743	2.0743	0.953	0
  rs17076972	Imputed	C	RECESSIVE	5.68E−05	5.68E−05	1.8279	1.8279	0.9528	0
  rs17189710	Imputed	T	ADDITIVE	0.0005045	0.0005045	1.3708	1.3708	0.7263	0
  rs17189710	Imputed	T	GENOTYPIC	0.0006517	0.0006517	1.9308	1.9308	0.8764	0
  rs17196143	Imputed	A	ADDITIVE	8.38E−05	8.38E−05	1.5602	1.5602	0.9412	0
  rs17353809	Imputed	G	ADDITIVE	5.27E−05	5.27E−05	1.5478	1.5478	0.7656	0
  rs17368986	Imputed	A	GENOTYPIC	8.61E−05	8.61E−05	3.6103	3.6103	0.3631	0
  rs17369097	Imputed	A	GENOTYPIC	9.78E−05	9.78E−05	3.572	3.572	0.5084	0
  rs17434511	Imputed	C	GENOTYPIC	8.13E−05	8.13E−05	3.6271	3.6271	0.3688	0
  rs17434589	Imputed	C	GENOTYPIC	7.42E−05	7.42E−05	3.6546	3.6546	0.3705	0
  rs17434603	Imputed	G	GENOTYPIC	8.48E−05	8.48E−05	3.6142	3.6142	0.3734	0
  rs17434840	Imputed	C	GENOTYPIC	9.78E−05	9.78E−05	3.572	3.572	0.5084	0
  rs17446418	Imputed	G	DOMINANT	3.25E−05	3.25E−05	0.587	0.587	0.3535	0
  rs17530747	Imputed	T	DOMINANT	2.26E−05	2.63E−05	0.5795	0.5797	0.3143	1.26
  rs17604285	Imputed	C	ADDITIVE	1.05E−05	1.05E−05	0.4906	0.4906	0.4675	0
  rs17604285	Imputed	C	DOMINANT	9.86E−06	9.86E−06	0.4707	0.4707	0.5868	0
  rs17662322	Imputed	T	DOMINANT	0.0001449	0.0001449	0.6002	0.6002	0.4533	0
  rs17769826	Imputed	T	ADDITIVE	5.88E−05	5.88E−05	1.5431	1.5431	0.7499	0
  rs17821641	Imputed	T	ADDITIVE	9.67E−05	9.67E−05	1.5246	1.5246	0.8383	0
  rs1782328	Imputed	A	ADDITIVE	2.46E−05	2.46E−05	0.6019	0.6019	0.8261	0
  rs1796337	Imputed	T	DOMINANT	0.0001492	0.0001492	0.576	0.576	0.7496	0
  rs1798083	Imputed	C	DOMINANT	3.81E−05	3.81E−05	0.5525	0.5525	0.4283	0
  rs1798085	Imputed	T	DOMINANT	1.84E−05	1.84E−05	0.538	0.538	0.506	0
  rs1798086	Imputed	T	DOMINANT	6.52E−06	6.52E−06	0.5214	0.5214	0.5861	0
  rs1798089	Imputed	C	GENOTYPIC	0.0003263	0.0003263	1.9613	1.9613	0.6074	0
  rs1798089	Imputed	C	RECESSIVE	4.85E−05	4.85E−05	1.9649	1.9649	0.6513	0
  rs1798090	Imputed	C	GENOTYPIC	0.0002913	0.0002913	1.9722	1.9722	0.6702	0
  rs1798090	Imputed	C	RECESSIVE	6.28E−05	6.28E−05	1.941	1.941	0.6999	0
  rs1832222	Imputed	G	DOMINANT	0.0001402	0.0004442	1.6153	1.6079	0.2874	11.66
  rs1838104	Imputed	A	ADDITIVE	6.20E−05	6.20E−05	0.6927	0.6927	0.4982	0
  rs1838104	Imputed	A	GENOTYPIC	7.67E−05	7.67E−05	0.4828	0.4828	0.4457	0
  rs1868616	Imputed	G	ADDITIVE	6.07E−05	6.07E−05	0.6201	0.6201	0.3729	0
  rs1874313	Imputed	A	DOMINANT	7.43E−05	7.43E−05	0.5922	0.5922	0.8066	0
  rs1884902	Imputed	C	RECESSIVE	6.21E−05	6.21E−05	2.0651	2.0651	0.5825	0
  rs1913201	Imputed	G	ADDITIVE	0.0004149	0.0004149	0.7177	0.7177	0.6151	0
  rs1913201	Imputed	G	DOMINANT	9.54E−05	9.54E−05	0.5843	0.5843	0.9445	0
  rs1913201	Imputed	G	GENOTYPIC	0.001991	0.001991	0.5555	0.5555	0.4282	0
  rs1944279	Imputed	A	ADDITIVE	2.61E−05	2.61E−05	1.5292	1.5292	0.6713	0
  rs198461	Imputed	C	DOMINANT	0.0001487	0.0001487	0.5632	0.5632	0.3797	0
  rs1987179	Imputed	T	DOMINANT	0.003872	0.003872	0.6885	0.6885	0.8528	0
  rs1990023	Imputed	T	DOMINANT	8.24E−06	8.24E−06	0.5675	0.5675	0.7214	0
  rs2016194	Imputed	G	DOMINANT	1.39E−05	1.39E−05	0.5753	0.5753	0.7864	0
  rs2024789	Imputed	C	ADDITIVE	7.32E−05	7.32E−05	0.7001	0.7001	0.5939	0
  rs2024789	Imputed	C	GENOTYPIC	9.80E−05	9.80E−05	0.4935	0.4935	0.6182	0
  rs2024902	Imputed	A	ADDITIVE	3.48E−05	3.48E−05	2.1731	2.1731	0.7139	0
  rs2024902	Imputed	A	DOMINANT	1.02E−05	1.02E−05	2.3955	2.3955	0.7005	0
  rs2025107	Imputed	A	ADDITIVE	1.24E−05	1.24E−05	2.1211	2.1211	0.6401	0
  rs2025107	Imputed	A	DOMINANT	1.83E−06	1.83E−06	2.4108	2.4108	0.5006	0
  rs2025108	Imputed	T	ADDITIVE	1.24E−05	1.24E−05	2.1211	2.1211	0.6401	0
  rs2025108	Imputed	T	DOMINANT	1.83E−06	1.83E−06	2.4108	2.4108	0.5006	0
  rs2062448	Imputed	T	ADDITIVE	1.78E−05	1.78E−05	0.4975	0.4975	0.4296	0
  rs2062448	Imputed	T	DOMINANT	1.73E−05	1.73E−05	0.4776	0.4776	0.5425	0
  rs2063591	Imputed	C	ADDITIVE	0.001202	0.001202	0.7439	0.7439	0.7716	0
  rs2063591	Imputed	C	DOMINANT	5.22E−05	5.22E−05	0.5704	0.5704	0.86	0
  rs2065604	Imputed	C	DOMINANT	7.75E−05	7.75E−05	0.5093	0.5093	0.7525	0
  rs2066238	Imputed	T	DOMINANT	6.31E−05	6.31E−05	0.5711	0.5711	0.3613	0
  rs2068051	Imputed	G	ADDITIVE	3.45E−05	3.45E−05	0.6225	0.6225	0.8406	0
  rs2068051	Imputed	G	GENOTYPIC	5.01E−05	5.01E−05	0.3895	0.3895	0.8309	0
  rs2077702	Genotyped	G	GENOTYPIC	0.002605	0.002605	1.8705	1.8705	0.3942	0
  rs208757	Imputed	G	ADDITIVE	0.001261	0.001261	1.4776	1.4776	0.5869	0
  rs208757	Imputed	G	DOMINANT	0.0009161	0.0009161	1.5787	1.5787	0.6624	0
  rs2095586	Imputed	A	DOMINANT	0.0001402	0.0004442	1.6153	1.6079	0.2874	11.66
  rs2108426	Imputed	C	DOMINANT	1.31E−05	1.31E−05	0.5744	0.5744	0.799	0
  rs2110664	Imputed	A	DOMINANT	0.0005399	0.0005399	1.568	1.568	0.6563	0
  rs2132242	Imputed	A	DOMINANT	0.0001181	0.0001181	0.6005	0.6005	0.7904	0
  rs2151644	Imputed	T	DOMINANT	7.40E−05	7.40E−05	0.5083	0.5083	0.7589	0
  rs2157752	Genotyped	A	GENOTYPIC	7.96E−05	7.96E−05	0.4178	0.4178	0.6318	0
  rs2158958	Imputed	A	DOMINANT	1.37E−05	1.37E−05	0.5753	0.5753	0.7855	0
  rs2158961	Imputed	G	DOMINANT	1.89E−05	1.89E−05	0.5806	0.5806	0.7575	0
  rs2164099	Imputed	G	ADDITIVE	3.91E−05	3.91E−05	1.51	1.51	0.6597	0
  rs2173254	Imputed	G	GENOTYPIC	4.24E−05	4.24E−05	0.3535	0.3535	0.8105	0
  rs2173254	Imputed	G	RECESSIVE	7.44E−05	7.44E−05	0.3802	0.3802	0.9734	0
  rs2188079	Imputed	C	ADDITIVE	1.42E−05	1.42E−05	1.4883	1.4883	0.9498	0
  rs2188079	Imputed	C	GENOTYPIC	1.20E−05	1.20E−05	2.2697	2.2697	0.9606	0
  rs2190304	Imputed	G	RECESSIVE	2.19E−05	9.93E−05	0.5028	0.5057	0.2831	13.22
  rs2190597	Imputed	T	DOMINANT	0.0009376	0.007487	0.6352	0.6427	0.2354	28.98
  rs2190598	Imputed	T	DOMINANT	1.37E−05	1.37E−05	0.5753	0.5753	0.7855	0
  rs2190600	Imputed	A	DOMINANT	1.57E−05	1.57E−05	0.8759	0.5759	0.7904	0
  rs2218084	Imputed	T	GENOTYPIC	0.0004323	0.0004323	4.066	4.066	0.7112	0
  rs2218084	Imputed	T	RECESSIVE	0.0006382	0.0006382	3.8693	3.8693	0.7945	0
  rs2236290	Genotyped	C	GENOTYPIC	0.001515	0.001515	0.5241	0.5241	0.9756	0
  rs2243860	Imputed	A	GENOTYPIC	0.0002795	0.0002795	2.2455	2.2455	0.9794	0
  rs2243860	Imputed	A	RECESSIVE	0.000191	0.000191	2.1324	2.1324	0.9082	0
  rs2246564	Imputed	T	DOMINANT	7.75E−05	7.75E−05	0.5093	0.5093	0.7525	0
  rs2248236	Imputed	C	DOMINANT	0.00556	0.00556	0.6993	0.6993	0.7827	0
  rs2250340	Imputed	T	DOMINANT	7.34E−05	7.34E−05	0.4999	0.4999	0.8201	0
  rs2257192	Imputed	G	DOMINANT	7.75E−05	7.75E−05	0.5093	0.5093	0.7525	0
  rs2270584	Imputed	A	DOMINANT	2.79E−05	2.79E−05	0.5781	0.5781	0.841	0
  rs2270586	Imputed	A	DOMINANT	2.34E−05	2.34E−05	0.5711	0.5711	0.8905	0
  rs2270589	Imputed	A	ADDITIVE	0.0002129	0.0002129	0.7047	0.7047	0.8921	0
  rs2270589	Imputed	A	DOMINANT	4.02E−06	4.02E−06	0.5172	0.5172	0.475	0
  rs2270589	Imputed	A	GENOTYPIC	0.0008832	0.0008832	0.5338	0.5338	0.9242	0
  rs2296889	Imputed	C	DOMINANT	9.73E−05	9.73E−05	1.7214	1.7214	0.635	0
  rs2301346	Imputed	C	ADDITIVE	1.33E−05	1.33E−05	1.592	1.592	0.8797	0
  rs2301346	Imputed	C	DOMINANT	8.84E−06	8.84E−06	1.8528	1.8528	0.6487	0
  rs2327929	Imputed	G	RECESSIVE	1.47E−05	1.47E−05	1.9741	1.9741	0.5579	0
  rs2357486	Imputed	C	RECESSIVE	9.81E−05	9.81E−05	2.3629	2.3629	0.3237	0
  rs2373793	Imputed	G	DOMINANT	0.0004772	0.0004772	1.624	1.624	0.608	0
  rs2377622	Imputed	T	GENOTYPIC	0.001009	0.001009	0.4327	0.4327	0.9416	0
  rs2377622	Imputed	T	RECESSIVE	0.001315	0.001315	0.4588	0.4588	0.779	0
  rs2383903	Imputed	G	DOMINANT	6.50E−05	6.50E−05	0.6039	0.6039	0.8634	0
  rs2389866	Imputed	C	DOMINANT	0.003524	0.003524	0.6859	0.6859	0.8694	0
  rs2389869	Imputed	C	DOMINANT	0.003524	0.003524	0.6859	0.6859	0.8694	0
  rs2418541	Imputed	A	DOMINANT	1.10E−05	1.10E−05	0.5722	0.5722	0.6924	0
  rs2418542	Imputed	A	DOMINANT	1.10E−05	1.10E−05	0.5722	0.5722	0.6924	0
  rs2418548	Imputed	C	DOMINANT	6.29E−05	6.29E−05	0.5957	0.5957	0.6795	0
  rs2476976	Imputed	C	DOMINANT	0.0002836	0.0002836	1.5809	1.5809	0.3487	0
  rs2483639	Imputed	A	DOMINANT	7.75E−05	7.75E−05	0.5093	0.5093	0.7525	0
  rs2483640	Imputed	A	DOMINANT	7.75E−05	7.75E−05	0.5093	0.5093	0.7525	0
  rs2544780	Imputed	T	RECESSIVE	0.003543	0.003543	1.8115	1.8115	0.7962	0
  rs2586458	Imputed	T	DOMINANT	9.34E−05	9.34E−05	0.471	0.471	0.709	0
  rs2593272	Imputed	G	ADDITIVE	7.80E−05	7.80E−05	0.6664	0.6664	0.4045	0
  rs2593273	Imputed	T	ADDITIVE	5.67E−05	5.67E−05	0.658	0.658	0.4571	0
  rs2622499	Imputed	G	DOMINANT	0.006454	0.006454	0.7042	0.7042	0.7526	0
  rs264126	Imputed	C	DOMINANT	0.0009755	0.0163	0.6364	0.6476	0.1951	40.44
  rs264129	Imputed	T	DOMINANT	1.71E−05	1.71E−05	0.5791	0.5791	0.7456	0
  rs2656822	Imputed	T	ADDITIVE	7.80E−05	7.80E−05	0.6664	0.6664	0.4045	0
  rs2656823	Imputed	G	ADDITIVE	7.80E−05	7.80E−05	0.6664	0.6664	0.4045	0
  rs2656825	Imputed	T	ADDITIVE	7.13E−05	7.13E−05	0.6492	0.6492	0.3189	0
  rs2764766	Imputed	C	RECESSIVE	0.003593	0.003593	1.7939	1.7939	0.9717	0
  rs2793101	Imputed	T	ADDITIVE	6.64E−05	6.64E−05	0.545	0.545	0.5015	0
  rs2793101	Imputed	T	DOMINANT	9.02E−05	9.02E−05	0.5344	0.5344	0.5893	0
  rs2795871	Imputed	A	ADDITIVE	0.0002982	0.0014	0.504	0.4941	0.2612	20.77
  rs2795886	Imputed	A	ADDITIVE	0.0002045	0.0002045	0.4388	0.4388	0.3702	0
  rs2795886	Imputed	A	DOMINANT	0.0003345	0.0003345	0.4401	0.4401	0.3569	0
  rs2859994	Imputed	C	GENOTYPIC	8.11E−05	8.11E−05	2.2234	2.2234	0.9879	0
  rs2870464	Imputed	G	DOMINANT	0.007714	0.007714	1.4837	1.4837	0.7312	0
  rs2875528	Imputed	T	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs2876227	Imputed	C	ADDITIVE	0.0003398	0.0003398	1.3941	1.3941	0.991	0
  rs2876227	Imputed	C	GENOTYPIC	0.0005058	0.0005058	1.9894	1.9894	0.6903	0
  rs2882097	Imputed	A	DOMINANT	0.000146	0.000146	1.6135	1.6135	0.3224	0
  rs2921983	Imputed	C	ADDITIVE	3.03E−05	3.03E−05	0.6367	0.6367	0.4592	0
  rs2987537	Imputed	C	DOMINANT	5.27E−05	5.27E−05	0.5308	0.5308	0.6212	0
  rs2996416	Imputed	C	ADDITIVE	6.90E−05	6.90E−05	0.5379	0.5379	0.7323	0
  rs2996416	Imputed	C	DOMINANT	4.54E−05	4.54E−05	0.5019	0.5019	0.6494	0
  rs3015527	Imputed	C	ADDITIVE	8.85E−05	8.85E−05	0.5427	0.5427	0.6864	0
  rs3015527	Imputed	C	DOMINANT	6.15E−05	6.15E−05	0.5073	0.5073	0.6044	0
  rs3015530	Imputed	C	ADDITIVE	6.55E−05	6.55E−05	0.5369	0.5369	0.7455	0
  rs3015530	Imputed	C	DOMINANT	4.31E−05	4.31E−05	0.5009	0.5009	0.6615	0
  rs3015531	Imputed	T	ADDITIVE	6.55E−05	6.55E−05	0.5369	0.5369	0.7455	0
  rs3015531	Imputed	T	DOMINANT	4.31E−05	4.31E−05	0.5009	0.5009	0.6615	0
  rs3015535	Imputed	C	ADDITIVE	6.55E−05	6.55E−05	0.5369	0.5369	0.7455	0
  rs3015535	Imputed	C	DOMINANT	4.31E−05	4.31E−05	0.5009	0.5009	0.6615	0
  rs3019407	Imputed	A	GENOTYPIC	3.61E−05	3.61E−05	0.3507	0.3507	0.848	0
  rs3019407	Imputed	A	RECESSIVE	5.80E−05	5.80E−05	0.3753	0.3753	0.9087	0
  rs36071725	Genotyped	C	GENOTYPIC	2.77E−05	2.77E−05	2.4392	2.4392	0.3383	0
  rs373983	Imputed	G	DOMINANT	0.0002104	0.02216	1.6446	1.5957	0.1398	54.13
  rs3756154	Imputed	C	DOMINANT	0.003524	0.003524	0.6859	0.6859	0.8694	0
  rs3793044	Imputed	C	ADDITIVE	1.34E−05	1.34E−05	2.303	2.303	0.9028	0
  rs3793044	Imputed	C	DOMINANT	5.24E−06	5.24E−06	2.505	2.505	0.845	0
  rs3793053	Imputed	C	ADDITIVE	2.09E−05	2.09E−05	2.0984	2.0984	0.7421	0
  rs3793053	Imputed	C	DOMINANT	4.49E−06	4.49E−06	2.3534	2.3534	0.5617	0
  rs3796246	Imputed	G	ADDITIVE	2.47E−06	6.16E−06	0.4525	0.4504	0.2993	7.17
  rs3796246	Imputed	G	DOMINANT	2.87E−06	2.87E−06	0.4415	0.4415	0.3413	0
  rs3805996	Imputed	G	ADDITIVE	2.67E−05	2.67E−05	2.2289	2.2289	0.7845	0
  rs3805996	Imputed	G	DOMINANT	6.94E−06	6.94E−06	2.4684	2.4684	0.7822	0
  rs3806003	Imputed	A	ADDITIVE	1.34E−05	1.34E−05	2.303	2.303	0.9028	0
  rs3806003	Imputed	A	DOMINANT	5.24E−06	5.24E−06	2.505	2.505	0.845	0
  rs3806004	Imputed	T	ADDITIVE	8.98E−06	8.98E−06	2.1456	2.1456	0.5726	0
  rs3806004	Imputed	T	DOMINANT	1.26E−06	1.26E−06	2.4405	2.4405	0.4411	0
  rs3806010	Imputed	T	ADDITIVE	1.24E−05	1.24E−05	2.1211	2.1211	0.6401	0
  rs3806010	Imputed	T	DOMINANT	1.83E−06	1.83E−06	2.4108	2.4108	0.5006	0
  rs3806014	Imputed	T	ADDITIVE	1.24E−05	1.24E−05	2.1211	2.1211	0.6401	0
  rs3806014	Imputed	T	DOMINANT	1.83E−06	1.83E−06	2.4108	2.4108	0.5006	0
  rs3806015	Imputed	A	ADDITIVE	1.24E−05	1.24E−05	2.1211	2.1211	0.6401	0
  rs3806015	Imputed	A	DOMINANT	1.83E−06	1.83E−06	2.4108	2.4108	0.5006	0
  rs3806018	Imputed	A	ADDITIVE	1.24E−05	1.24E−05	2.1211	2.1211	0.6401	0
  rs3806018	Imputed	A	DOMINANT	1.83E−06	1.83E−06	2.4108	2.4108	0.5006	0
  rs3806019	Imputed	A	ADDITIVE	4.82E−06	4.82E−06	2.2211	2.2211	0.774	0
  rs3806019	Imputed	A	DOMINANT	7.89E−07	7.89E−07	2.5148	2.5148	0.6004	0
  rs3806024	Imputed	T	ADDITIVE	2.13E−05	2.13E−05	2.0967	2.0967	0.7474	0
  rs3806024	Imputed	T	DOMINANT	4.58E−06	4.58E−06	2.3513	2.3513	0.5665	0
  rs3847825	Imputed	G	ADDITIVE	0.0001755	0.0001755	0.7117	0.7117	0.6477	0
  rs3847825	Imputed	G	GENOTYPIC	0.0004069	0.0004069	0.504	0.504	0.39	0
  rs3852001	Genotyped	C	GENOTYPIC	5.01E−05	5.01E−05	3.7361	3.7361	0.4411	0
  rs3852001	Genotyped	C	RECESSIVE	6.81E−05	6.81E−05	3.6068	3.6068	0.5248	0
  rs3852002	Imputed	G	GENOTYPIC	6.98E−05	6.98E−05	3.6551	3.6551	0.4732	0
  rs3852002	Imputed	G	RECESSIVE	9.73E−05	9.73E−05	3.5189	3.5189	0.5652	0
  rs3852003	Imputed	A	GENOTYPIC	6.98E−05	6.98E−05	3.6551	3.6551	0.4732	0
  rs3852003	Imputed	A	RECESSIVE	9.73E−05	9.73E−05	3.5189	3.5189	0.5652	0
  rs3942254	Imputed	T	DOMINANT	0.0001204	0.0001204	0.5984	0.5984	0.9786	0
  rs3945085	Imputed	A	DOMINANT	8.89E−05	8.89E−05	1.637	1.637	0.3315	0
  rs399485	Imputed	A	DOMINANT	0.001889	0.001889	1.4784	1.4784	0.6793	0
  rs4029119	Imputed	G	ADDITIVE	2.71E−05	2.71E−05	0.1993	0.1993	0.5787	0
  rs4029119	Imputed	G	DOMINANT	5.28E−05	5.28E−05	0.203	0.203	0.5644	0
  rs412791	Imputed	C	GENOTYPIC	9.99E−05	9.99E−05	0.4339	0.4339	0.5099	0
  rs4146972	Genotyped	T	DOMINANT	0.003205	0.003205	1.4961	1.4961	0.5773	0
  rs4259369	Imputed	C	RECESSIVE	0.0002939	0.00425	0.557	0.5415	0.2009	38.87
  rs4273613	Imputed	T	ADDITIVE	3.41E−05	3.41E−05	0.2206	0.2206	0.9267	0
  rs4273613	Imputed	T	DOMINANT	6.55E−05	6.55E−05	0.2253	0.2253	0.9509	0
  rs4294022	Imputed	C	DOMINANT	8.50E−05	8.50E−05	0.6007	0.6007	0.6113	0
  rs4310554	Genotyped	C	DOMINANT	0.0005487	0.0005487	1.6987	1.6987	0.7993	0
  rs4315598	Imputed	T	ADDITIVE	0.0005594	0.0005594	1.3676	1.3676	0.7519	0
  rs4315598	Imputed	T	GENOTYPIC	0.0006963	0.0006963	1.9242	1.9242	0.8583	0
  rs4370878	Imputed	G	DOMINANT	0.0001382	0.0001382	1.6143	1.6143	0.3748	0
  rs4436200	Imputed	C	ADDITIVE	0.00342	0.00342	0.6695	0.6695	0.4811	0
  rs4444612	Imputed	G	ADDITIVE	0.0005045	0.0005045	1.3708	1.3708	0.7263	0
  rs4444612	Imputed	G	GENOTYPIC	0.0006517	0.0006517	1.9308	1.9308	0.8764	0
  rs4450660	Imputed	C	DOMINANT	5.07E−05	5.07E−05	1.6768	1.6768	0.885	0
  rs4463950	Imputed	C	DOMINANT	9.57E−05	9.57E−05	0.5933	0.5933	0.705	0
  rs4509702	Imputed	C	DOMINANT	0.0001382	0.0001382	1.6143	1.6143	0.3748	0
  rs4533379	Imputed	G	ADDITIVE	3.75E−05	3.75E−05	1.5121	1.5121	0.6724	0
  rs4569984	Imputed	A	DOMINANT	7.78E−05	7.78E−05	0.5998	0.5998	0.4464	0
  rs4570530	Imputed	C	DOMINANT	0.0001225	0.0001225	1.6207	1.6207	0.3622	0
  rs4571583	Imputed	T	DOMINANT	9.79E−05	9.79E−05	0.6041	0.6041	0.5	0
  rs4586678	Imputed	A	DOMINANT	6.09E−05	6.09E−05	1.6655	1.6655	0.8543	0
  rs4615971	Imputed	C	DOMINANT	0.0001283	0.0006247	1.6223	1.612	0.275	16.09
  rs4629229	Imputed	G	DOMINANT	6.31E−05	6.31E−05	0.5711	0.5711	0.3613	0
  rs4632512	Imputed	T	GENOTYPIC	9.78E−05	9.78E−05	3.572	3.572	0.5084	0
  rs4641552	Imputed	A	ADDITIVE	0.0002608	0.0002608	0.5241	0.5241	0.9002	0
  rs4682527	Imputed	C	DOMINANT	8.72E−05	8.72E−05	1.6904	1.6904	0.7615	0
  rs4688632	Imputed	G	RECESSIVE	0.0003309	0.0003309	0.5825	0.5825	0.5195	0
  rs4702720	Imputed	A	ADDITIVE	0.0001627	0.0001627	0.6287	0.6287	0.5601	0
  rs4702720	Imputed	A	DOMINANT	0.0004444	0.0004444	0.5961	0.5961	0.3979	0
  rs4714484	Imputed	A	ADDITIVE	6.98E−05	6.98E−05	0.6183	0.6183	0.8333	0
  rs4714484	Imputed	A	DOMINANT	5.02E−05	5.02E−05	0.5696	0.5696	0.55	0
  rs4725142	Genotyped	G	RECESSIVE	7.87E−05	7.87E−05	0.4243	0.4243	0.7642	0
  rs4725144	Imputed	G	RECESSIVE	6.02E−05	6.02E−05	0.4125	0.4125	0.8332	0
  rs4760785	Imputed	A	ADDITIVE	0.0006364	0.0006364	0.728	0.728	0.7009	0
  rs4760785	Imputed	A	DOMINANT	0.0001126	0.0001126	0.5881	0.5881	0.915	0
  rs4760894	Imputed	T	ADDITIVE	0.0006364	0.0006364	0.728	0.728	0.7009	0
  rs4760894	Imputed	T	DOMINANT	0.0001126	0.0001126	0.5881	0.5881	0.915	0
  rs4760895	Imputed	A	ADDITIVE	0.0006364	0.0006364	0.728	0.728	0.7009	0
  rs4760895	Imputed	A	DOMINANT	0.0001126	0.0001126	0.5881	0.5881	0.915	0
  rs4767184	Imputed	C	ADDITIVE	0.0002343	0.0002343	0.7168	0.7168	0.7754	0
  rs4767184	Imputed	C	GENOTYPIC	0.0008747	0.0008747	0.5298	0.5298	0.5351	0
  rs4773487	Imputed	T	ADDITIVE	9.48E−05	9.48E−05	0.5543	0.5543	0.9938	0
  rs4780547	Imputed	G	GENOTYPIC	0.002606	0.002606	0.3778	0.3778	0.4518	0
  rs4780547	Imputed	G	RECESSIVE	0.002641	0.002641	0.3832	0.3832	0.5083	0
  rs483159	Imputed	T	DOMINANT	0.001618	0.01337	1.5311	1.5114	0.2239	32.38
  rs4836502	Imputed	T	DOMINANT	1.37E−05	1.37E−05	0.5753	0.5753	0.7855	0
  rs4836507	Imputed	C	DOMINANT	1.68E−05	1.68E−05	0.5765	0.5765	0.7813	0
  rs4851531	Imputed	T	DOMINANT	0.00133	0.00133	0.6585	0.6585	0.3468	0
  rs4879931	Imputed	G	ADDITIVE	0.0002697	0.0002697	0.7001	0.7001	0.5714	0
  rs489441	Imputed	G	ADDITIVE	6.35E−05	6.35E−05	1.5268	1.5268	0.8611	0
  rs489441	Imputed	G	DOMINANT	5.90E−05	5.90E−05	1.6921	1.6921	0.6161	0
  rs4976276	Imputed	T	ADDITIVE	8.75E−05	8.75E−05	1.4687	1.4687	0.8689	0
  rs4977681	Imputed	C	RECESSIVE	9.61E−05	9.61E−05	2.314	2.314	0.6823	0
  rs4986197	Imputed	G	ADDITIVE	3.97E−05	3.97E−05	1.5105	1.5105	0.6441	0
  rs4986220	Imputed	T	ADDITIVE	5.91E−05	5.91E−05	1.5005	1.5005	0.7465	0
  rs525462	Imputed	A	GENOTYPIC	0.0007973	0.004961	0.5445	0.5308	0.2306	30.4
  rs552006	Imputed	G	GENOTYPIC	9.06E−05	9.06E−05	2.4662	2.4662	0.4679	0
  rs5756669	Imputed	C	DOMINANT	7.71E−05	7.71E−05	1.7362	1.7362	0.7477	0
  rs581905	Imputed	T	DOMINANT	0.008112	0.008112	1.5819	1.5819	0.4663	0
  rs6033138	Imputed	C	ADDITIVE	0.0005045	0.0005045	1.3708	1.3708	0.7263	0
  rs6033138	Imputed	C	GENOTYPIC	0.0006517	0.0006517	1.9308	1.9308	0.8764	0
  rs6040619	Imputed	C	ADDITIVE	0.000474	0.000474	1.3729	1.3729	0.7285	0
  rs6040619	Imputed	C	GENOTYPIC	0.0005591	0.0005591	1.9442	1.9442	0.9167	0
  rs6040625	Imputed	T	ADDITIVE	0.0003079	0.0003079	1.3859	1.3859	0.7073	0
  rs6040625	Imputed	T	GENOTYPIC	0.000416	0.000416	1.9717	1.9717	0.9604	0
  rs6040630	Imputed	A	ADDITIVE	0.0003026	0.0003026	1.3874	1.3874	0.7384	0
  rs6040630	Imputed	A	GENOTYPIC	0.0004609	0.0004609	1.9676	1.9676	0.9146	0
  rs6040633	Imputed	A	ADDITIVE	0.0003456	0.0003456	1.3823	1.3823	0.78	0
  rs6040633	Imputed	A	GENOTYPIC	0.0005613	0.0005613	1.945	1.945	0.8535	0
  rs6040634	Imputed	T	ADDITIVE	0.00085	0.00085	1.3491	1.3491	0.6301	0
  rs6040634	Imputed	T	GENOTYPIC	0.001411	0.001411	1.8378	1.8378	0.9672	0
  rs6040636	Imputed	T	ADDITIVE	0.0007597	0.0007597	1.3531	1.3531	0.6477	0
  rs6040636	Imputed	T	GENOTYPIC	0.001336	0.001336	1.8436	1.8436	0.9771	0
  rs6040638	Imputed	C	ADDITIVE	0.0005045	0.0005045	1.3708	1.3708	0.7263	0
  rs6040638	Imputed	C	GENOTYPIC	0.0006517	0.0006517	1.9308	1.9308	0.8764	0
  rs6040644	Imputed	A	ADDITIVE	0.0005045	0.0005045	1.3708	1.3708	0.7263	0
  rs6040644	Imputed	A	GENOTYPIC	0.0006517	0.0006517	1.9308	1.9308	0.8764	0
  rs6040667	Imputed	T	ADDITIVE	0.0002261	0.0002261	1.4034	1.4034	0.9253	0
  rs6040667	Imputed	T	GENOTYPIC	0.0003915	0.0003915	2.0113	2.0113	0.742	0
  rs6040668	Imputed	C	ADDITIVE	0.0002261	0.0002261	1.4034	1.4034	0.9253	0
  rs6040668	Imputed	C	GENOTYPIC	0.0003915	0.0003915	2.0113	2.0113	0.742	0
  rs6053005	Imputed	C	DOMINANT	0.00111	0.01291	0.5203	0.5059	0.1794	44.53
  rs6054405	Imputed	A	RECESSIVE	5.03E−05	5.03E−05	2.0846	2.0846	0.5572	0
  rs6054427	Genotyped	G	GENOTYPIC	9.31E−05	9.31E−05	2.1425	2.1425	0.5656	0
  rs6075186	Imputed	G	DOMINANT	6.31E−05	6.31E−05	0.5711	0.5711	0.3613	0
  rs608278	Imputed	A	ADDITIVE	7.01E−05	7.01E−05	0.6797	0.6797	0.6622	0
  rs6111540	Imputed	A	ADDITIVE	8.63E−05	8.63E−05	0.6872	0.6872	0.3404	0
  rs6131206	Imputed	C	ADDITIVE	0.001921	0.001921	1.3434	1.3434	0.4914	0
  rs6131208	Imputed	T	ADDITIVE	0.0002261	0.0002261	1.4034	1.4034	0.9253	0
  rs6131208	Imputed	T	GENOTYPIC	0.0003915	0.0003915	2.0113	2.0113	0.742	0
  rs6131919	Imputed	G	DOMINANT	6.31E−05	6.31E−05	0.5711	0.5711	0.3613	0
  rs6134243	Imputed	C	ADDITIVE	0.0005045	0.0005045	1.3708	1.3708	0.7263	0
  rs6134243	Imputed	C	GENOTYPIC	0.0006517	0.0006517	1.9308	1.9308	0.8764	0
  rs6136020	Imputed	A	DOMINANT	4.47E−05	4.47E−05	0.564	0.564	0.3277	0
  rs613799	Imputed	C	DOMINANT	0.0002168	0.0002168	1.6378	1.6378	0.4057	0
  rs644041	Imputed	G	ADDITIVE	4.10E−05	4.10E−05	1.5491	1.5491	0.9018	0
  rs644041	Imputed	G	DOMINANT	6.67E−05	6.67E−05	1.6947	1.6947	0.6929	0
  rs6464377	Imputed	C	DOMINANT	8.03E−05	8.03E−05	2.035	2.035	0.5161	0
  rs6474230	Imputed	T	DOMINANT	0.0001096	0.0001096	1.6401	1.6401	0.5183	0
  rs6476565	Imputed	A	DOMINANT	7.38E−05	7.38E−05	0.5063	0.5063	0.7702	0
  rs6511286	Imputed	T	ADDITIVE	8.56E−05	8.56E−05	1.4548	1.4548	0.3238	0
  rs6541829	Genotyped	C	RECESSIVE	0.0008971	0.0008971	2.3027	2.3027	0.4111	0
  rs6544721	Imputed	G	DOMINANT	4.51E−05	4.51E−05	1.6786	1.6786	0.7237	0
  rs6544728	Imputed	T	DOMINANT	3.81E−05	3.81E−05	1.6924	1.6924	0.7254	0
  rs6565910	Imputed	G	DOMINANT	6.35E−05	6.35E−05	0.596	0.596	0.7271	0
  rs6581985	Imputed	G	GENOTYPIC	0.0008728	0.0008728	2.1776	2.1776	0.7023	0
  rs6581985	Imputed	G	RECESSIVE	0.0003781	0.0003781	2.2212	2.2212	0.8679	0
  rs6685186	Imputed	T	ADDITIVE	4.04E−05	4.04E−05	1.4552	1.4552	0.5991	0
  rs6685186	Imputed	T	GENOTYPIC	7.87E−05	7.87E−05	2.1208	2.1208	0.5157	0
  rs670593	Imputed	A	RECESSIVE	0.004705	0.004705	0.6026	0.6026	0.9153	0
  rs6722640	Imputed	T	DOMINANT	0.0009277	0.0009277	0.6505	0.6505	0.4929	0
  rs6746170	Imputed	A	DOMINANT	3.13E−05	3.13E−05	1.7022	1.7022	0.7235	0
  rs6757316	Imputed	A	GENOTYPIC	0.0002411	0.0002411	1.9498	1.9498	0.7316	0
  rs6805139	Imputed	G	DOMINANT	0.000179	0.000179	1.7522	1.7522	0.7218	0
  rs6808571	Imputed	G	ADDITIVE	5.06E−05	5.06E−05	1.6529	1.6529	0.3901	0
  rs6816479	Imputed	A	RECESSIVE	8.91E−05	8.91E−05	2.0191	2.0191	0.6804	0
  rs6865976	Imputed	C	DOMINANT	1.69E−05	1.69E−05	0.5245	0.5245	0.8417	0
  rs687047	Imputed	C	ADDITIVE	0.002064	0.002064	0.6519	0.6519	0.6436	0
  rs6871041	Imputed	G	DOMINANT	1.86E−05	1.86E−05	0.571	0.571	0.7023	0
  rs688358	Imputed	A	ADDITIVE	0.001723	0.001723	0.6472	0.6472	0.7547	0
  rs6908481	Imputed	C	RECESSIVE	2.93E−05	2.93E−05	1.9907	1.9907	0.715	0
  rs6917224	Imputed	A	ADDITIVE	8.07E−05	8.07E−05	1.4126	1.4126	0.6894	0
  rs6917224	Imputed	A	GENOTYPIC	6.12E−05	6.12E−05	2.0516	2.0516	0.8021	0
  rs6920677	Imputed	G	DOMINANT	9.74E−05	9.74E−05	0.6022	0.6022	0.3637	0
  rs6994498	Imputed	G	DOMINANT	0.0001214	0.0001214	1.6355	1.6355	0.5075	0
  rs6998772	Imputed	T	DOMINANT	3.05E−05	3.05E−05	2.6244	2.6244	0.9125	0
  rs7022281	Imputed	C	ADDITIVE	0.0008616	0.0008616	0.7327	0.7327	0.9461	0
  rs7022281	Imputed	C	GENOTYPIC	0.0008065	0.0008065	0.5109	0.5109	0.8632	0
  rs7022281	Imputed	C	RECESSIVE	0.003772	0.003772	0.5858	0.5858	0.653	0
  rs7043983	Imputed	T	DOMINANT	7.81E−05	7.81E−05	0.5075	0.5075	0.763	0
  rs7077799	Imputed	A	DOMINANT	0.0001618	0.0002489	1.6085	1.6059	0.3065	4.35
  rs7088947	Imputed	A	ADDITIVE	0.0002561	0.002122	0.5006	0.4865	0.237	28.49
  rs7089661	Imputed	C	DOMINANT	0.0001402	0.0004442	1.6153	1.6079	0.2874	11.66
  rs7102072	Imputed	A	DOMINANT	2.00E−05	2.00E−05	0.5832	0.5832	0.7992	0
  rs710832	Genotyped	A	RECESSIVE	0.0003556	0.0003556	0.3515	0.3515	0.5598	0
  rs712531	Imputed	A	DOMINANT	4.12E−05	4.12E−05	1.7164	1.7164	0.821	0
  rs7129817	Imputed	T	ADDITIVE	8.64E−05	8.64E−05	0.6917	0.6917	0.9871	0
  rs7134262	Imputed	T	GENOTYPIC	0.000667	0.000667	2.0059	2.0059	0.482	0
  rs7134262	Imputed	T	RECESSIVE	1.92E−05	0.0001342	2.2604	2.2418	0.2719	17.17
  rs7138300	Imputed	C	ADDITIVE	0.0006364	0.0006364	0.728	0.728	0.7009	0
  rs7138300	Imputed	C	DOMINANT	0.0001126	0.0001126	0.5881	0.5881	0.915	0
  rs722927	Imputed	G	ADDITIVE	5.34E−05	5.34E−05	0.4718	0.4718	0.7351	0
  rs722927	Imputed	G	DOMINANT	5.76E−05	5.76E−05	0.4589	0.4589	0.8222	0
  rs726424	Genotyped	G	ADDITIVE	0.0002921	0.0002921	0.7216	0.7216	0.7796	0
  rs726424	Genotyped	G	GENOTYPIC	0.0006575	0.0006575	0.5204	0.5204	0.4936	0
  rs7295817	Imputed	C	ADDITIVE	4.33E−05	4.33E−05	0.6912	0.6912	0.586	0
  rs7295817	Imputed	C	GENOTYPIC	6.93E−05	6.93E−05	0.4694	0.4694	0.3851	0
  rs7295817	Imputed	C	RECESSIVE	0.001037	0.01025	0.5648	0.5757	0.2268	31.55
  rs7297372	Imputed	A	ADDITIVE	0.0002771	0.0002771	0.7072	0.7072	0.6868	0
  rs7297372	Imputed	A	GENOTYPIC	0.0002766	0.0002766	0.4963	0.4963	0.7085	0
  rs7298255	Imputed	A	ADDITIVE	0.0006976	0.0006976	0.7332	0.7332	0.8654	0
  rs7298255	Imputed	A	DOMINANT	6.68E−05	6.68E−05	0.5792	0.5792	0.9355	0
  rs7305832	Imputed	C	GENOTYPIC	0.000667	0.000667	2.0059	2.0059	0.482	0
  rs7305832	Imputed	C	RECESSIVE	1.92E−05	0.0001342	2.2604	2.2418	0.2719	17.17
  rs737542	Imputed	A	RECESSIVE	0.0006435	0.0007974	2.3828	2.3899	0.3091	3.32
  rs742827	Imputed	A	ADDITIVE	0.0002216	0.0002216	1.411	1.411	0.9765	0
  rs742827	Imputed	A	GENOTYPIC	0.0004335	0.0004335	2.0079	2.0079	0.73	0
  rs7446891	Imputed	G	DOMINANT	1.34E−05	1.34E−05	0.5737	0.5737	0.819	0
  rs7448641	Imputed	C	ADDITIVE	2.13E−05	2.13E−05	0.1976	0.1976	0.798	0
  rs7448641	Imputed	C	DOMINANT	3.85E−05	3.85E−05	0.2007	0.2007	0.8145	0
  rs7460605	Imputed	G	DOMINANT	0.0004965	0.0004965	1.5998	1.5998	0.8118	0
  rs7468898	Imputed	T	ADDITIVE	4.70E−05	4.70E−05	1.4562	1.4562	0.6548	0
  rs7468898	Imputed	T	GENOTYPIC	5.27E−05	5.27E−05	2.1254	2.1254	0.7376	0
  rs7501186	Imputed	A	DOMINANT	0.009359	0.009359	1.4572	1.4572	0.5108	0
  rs755117	Imputed	A	DOMINANT	8.93E−05	8.93E−05	1.6937	1.6937	0.8341	0
  rs7557560	Imputed	T	GENOTYPIC	1.52E−05	1.52E−05	4.8002	4.8002	0.5006	0
  rs7557560	Imputed	T	RECESSIVE	1.73E−05	1.73E−05	4.6869	4.6869	0.4673	0
  rs7562462	Imputed	T	DOMINANT	3.98E−05	3.98E−05	1.7863	1.7863	0.5531	0
  rs757173	Genotyped	G	DOMINANT	3.67E−05	3.67E−05	0.5903	0.5903	0.3929	0
  rs7607447	Imputed	T	RECESSIVE	0.004354	0.004354	1.9039	1.9039	0.9167	0
  rs7639053	Imputed	A	ADDITIVE	6.32E−05	6.32E−05	1.5389	1.5389	0.7877	0
  rs7648163	Imputed	C	RECESSIVE	4.30E−05	4.30E−05	2.2905	2.2905	0.3422	0
  rs7651273	Imputed	A	GENOTYPIC	7.69E−05	7.69E−05	3.6491	3.6491	0.3606	0
  rs7653190	Imputed	C	ADDITIVE	5.88E−05	5.88E−05	1.5431	1.5431	0.7499	0
  rs7653685	Genotyped	C	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs7684899	Imputed	C	DOMINANT	0.005003	0.005003	0.6963	0.6963	0.8023	0
  rs7701604	Imputed	G	ADDITIVE	2.13E−05	2.13E−05	0.1976	0.1976	0.798	0
  rs7701604	Imputed	G	DOMINANT	3.85E−05	3.85E−05	0.2007	0.2007	0.8145	0
  rs7703676	Imputed	C	ADDITIVE	2.13E−05	2.13E−05	0.1976	0.1976	0.798	0
  rs7703676	Imputed	C	DOMINANT	3.85E−05	3.85E−05	0.2007	0.2007	0.8145	0
  rs7711358	Imputed	A	DOMINANT	2.03E−05	2.03E−05	0.5813	0.5813	0.7623	0
  rs7713251	Imputed	C	RECESSIVE	7.07E−05	7.07E−05	2.2563	2.2563	0.6403	0
  rs7737608	Imputed	G	DOMINANT	2.24E−05	2.24E−05	1.7514	1.7514	0.3895	0
  rs7755903	Imputed	A	GENOTYPIC	9.90E−05	9.90E−05	0.4763	0.4763	0.3374	0
  rs7762993	Imputed	A	ADDITIVE	3.64E−05	3.64E−05	1.5999	1.5999	0.3438	0
  rs7762993	Imputed	A	DOMINANT	5.71E−06	5.71E−06	1.8249	1.8249	0.3301	0
  rs7767265	Imputed	G	DOMINANT	1.54E−06	9.09E−05	1.8708	1.8488	0.2364	28.66
  rs7769415	Imputed	C	GENOTYPIC	0.01222	0.01222	1.7102	1.7102	0.8943	0
  rs7771264	Imputed	T	DOMINANT	9.73E−05	9.73E−05	0.6028	0.6028	0.5969	0
  rs7795792	Imputed	T	RECESSIVE	0.0002939	0.00425	0.557	0.5415	0.2009	38.87
  rs7806481	Imputed	G	RECESSIVE	2.19E−05	9.93E−05	0.5028	0.5057	0.2831	13.22
  rs7808536	Imputed	G	DOMINANT	0.0002294	0.00065	1.6124	1.6227	0.2799	14.36
  rs7814819	Imputed	G	ADDITIVE	0.000435	0.000435	2.1517	2.1517	0.4796	0
  rs7814819	Imputed	G	DOMINANT	0.0002065	0.0002065	2.333	2.333	0.5524	0
  rs7815952	Imputed	T	DOMINANT	3.05E−05	3.05E−05	2.6244	2.6244	0.9125	0
  rs7834090	Imputed	T	DOMINANT	3.05E−05	3.05E−05	2.6244	2.6244	0.9125	0
  rs7859250	Imputed	C	DOMINANT	6.27E−05	6.27E−05	0.5033	0.5033	0.7889	0
  rs7863577	Genotyped	A	ADDITIVE	5.37E−05	5.37E−05	0.5145	0.5145	0.5515	0
  rs7863577	Genotyped	A	DOMINANT	8.32E−05	8.32E−05	0.5032	0.5032	0.6829	0
  rs7902140	Imputed	C	ADDITIVE	8.00E−05	8.00E−05	0.6274	0.6274	0.9605	0
  rs7921834	Imputed	C	DOMINANT	0.0001402	0.0004442	1.6153	1.6079	0.2874	11.66
  rs7939893	Imputed	C	ADDITIVE	0.001509	0.001509	0.7466	0.7466	0.4075	0
  rs7939893	Imputed	C	DOMINANT	0.0007741	0.0007741	0.6536	0.6536	0.8293	0
  rs7955901	Imputed	C	ADDITIVE	0.0008458	0.0008458	0.7371	0.7371	0.7791	0
  rs7955901	Imputed	C	DOMINANT	7.14E−05	7.14E−05	0.5799	0.5799	0.9786	0
  rs7956274	Imputed	T	ADDITIVE	0.001224	0.001224	0.7429	0.7429	0.9488	0
  rs7956274	Imputed	T	DOMINANT	0.0001094	0.0001094	0.5876	0.5876	0.8703	0
  rs7957932	Imputed	G	ADDITIVE	0.001498	0.001498	0.7467	0.7467	0.8677	0
  rs7957932	Imputed	G	DOMINANT	5.69E−05	5.69E−05	0.5706	0.5706	0.9859	0
  rs7984294	Imputed	A	DOMINANT	0.00858	0.00858	1.5738	1.5738	0.5291	0
  rs7994286	Imputed	A	ADDITIVE	9.63E−05	9.63E−05	0.549	0.549	0.854	0
  rs7994286	Imputed	A	DOMINANT	7.82E−05	7.82E−05	0.5161	0.5161	0.7893	0
  rs8038229	Genotyped	A	ADDITIVE	0.001259	0.01927	0.7324	0.7157	0.155	50.55
  rs8038229	Genotyped	A	DOMINANT	0.0009849	0.007544	0.6614	0.6497	0.2113	36.01
  rs8043336	Imputed	C	GENOTYPIC	7.96E−05	7.96E−05	0.3958	0.3958	0.4455	0
  rs8043336	Imputed	C	RECESSIVE	8.36E−05	8.36E−05	0.4142	0.4142	0.5943	0
  rs8054431	Imputed	T	DOMINANT	2.45E−05	2.45E−05	1.7571	1.7571	0.4329	0
  rs8066502	Imputed	T	DOMINANT	0.006801	0.006801	0.683	0.683	0.9956	0
  rs8068714	Imputed	T	DOMINANT	0.006941	0.006941	0.6836	0.6836	0.8713	0
  rs892575	Imputed	T	ADDITIVE	5.64E−05	5.64E−05	1.4995	1.4995	0.67	0
  rs892583	Imputed	G	ADDITIVE	5.66E−05	5.66E−05	1.5024	1.5024	0.7396	0
  rs915494	Imputed	A	ADDITIVE	0.0008012	0.008128	1.402	1.3898	0.223	32.66
  rs915494	Imputed	A	DOMINANT	0.0001453	0.01549	1.6314	1.5891	0.1486	52.08
  rs917295	Imputed	G	DOMINANT	1.41E−05	1.41E−05	0.5759	0.5759	0.7897	0
  rs922594	Imputed	T	DOMINANT	0.00224	0.00224	0.6774	0.6774	0.3822	0
  rs9301653	Imputed	T	ADDITIVE	6.55E−05	6.55E−05	0.5369	0.5369	0.7455	0
  rs9301653	Imputed	T	DOMINANT	4.31E−05	4.31E−05	0.5009	0.5009	0.6615	0
  rs9309988	Imputed	G	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs9309989	Genotyped	C	DOMINANT	3.87E−05	3.87E−05	1.9491	1.9491	0.3231	0
  rs9310221	Imputed	A	DOMINANT	9.78E−06	3.80E−05	1.86	1.8519	0.2901	10.65
  rs9327555	Imputed	T	DOMINANT	1.37E−05	1.37E−05	0.5753	0.5753	0.7855	0
  rs937890	Imputed	G	DOMINANT	0.005817	0.005817	0.6731	0.6731	0.8017	0
  rs9454967	Imputed	G	ADDITIVE	7.03E−06	7.03E−06	2.1926	2.1926	0.7348	0
  rs9454967	Imputed	G	DOMINANT	1.21E−06	1.21E−06	2.4795	2.4795	0.5648	0
  rs9471295	Imputed	T	DOMINANT	0.002076	0.002076	1.5391	1.5391	0.8556	0
  rs9477007	Imputed	A	ADDITIVE	5.88E−05	5.88E−05	1.429	1.429	0.6453	0
  rs9477007	Imputed	A	GENOTYPIC	5.42E−05	5.42E−05	2.0759	2.0759	0.7341	0
  rs9487279	Imputed	T	DOMINANT	9.53E−05	9.53E−05	0.5948	0.5948	0.7903	0
  rs949016	Imputed	C	ADDITIVE	4.61E−05	4.61E−05	1.5082	1.5082	0.7183	0
  rs9555973	Imputed	G	ADDITIVE	9.09E−05	9.09E−05	0.5479	0.5479	0.8574	0
  rs9555973	Imputed	G	DOMINANT	7.60E−05	7.60E−05	0.5157	0.5157	0.808	0
  rs9557510	Imputed	G	ADDITIVE	0.0001379	0.0001379	1.6102	1.6102	0.9088	0
  rs9557510	Imputed	G	DOMINANT	4.86E−05	4.86E−05	1.7706	1.7706	0.9892	0
  rs9560584	Imputed	T	DOMINANT	8.00E−05	8.00E−05	0.512	0.512	0.7127	0
  rs9588770	Imputed	T	DOMINANT	8.97E−05	8.97E−05	0.5187	0.5187	0.86	0
  rs9588848	Imputed	C	ADDITIVE	6.55E−05	6.55E−05	0.5369	0.5369	0.7455	0
  rs9588848	Imputed	C	DOMINANT	4.31E−05	4.31E−05	0.5009	0.5009	0.6615	0
  rs966583	Imputed	A	ADDITIVE	0.00064	0.00064	0.7272	0.7272	0.9721	0
  rs966583	Imputed	A	DOMINANT	6.94E−05	6.94E−05	0.5916	0.5916	0.8081	0
  rs974130	Genotyped	A	RECESSIVE	9.67E−05	9.67E−05	2.0112	2.0112	0.6677	0
  rs977160	Imputed	T	ADDITIVE	1.90E−05	1.90E−05	1.5465	1.5465	0.3814	0
  rs9812206	Imputed	G	ADDITIVE	1.27E−06	1.27E−06	0.4469	0.4469	0.5437	0
  rs9812206	Imputed	G	DOMINANT	1.72E−06	1.72E−06	0.4369	0.4369	0.61	0
  rs9813552	Imputed	G	ADDITIVE	2.01E−06	2.01E−06	0.4493	0.4493	0.4991	0
  rs9813552	Imputed	G	DOMINANT	2.40E−06	2.40E−06	0.4387	0.4387	0.5642	0
  rs9815037	Imputed	T	ADDITIVE	1.57E−06	1.57E−06	0.4461	0.4461	0.5119	0
  rs9815037	Imputed	T	DOMINANT	1.83E−06	1.83E−06	0.4354	0.4354	0.5792	0
  rs9825349	Imputed	A	ADDITIVE	1.57E−06	1.57E−06	0.4461	0.4461	0.5119	0
  rs9825349	Imputed	A	DOMINANT	1.83E−06	1.83E−06	0.4354	0.4354	0.5792	0
  rs9834217	Imputed	T	ADDITIVE	1.61E−06	1.61E−06	0.4466	0.4466	0.5093	0
  rs9834217	Imputed	T	DOMINANT	1.89E−06	1.89E−06	0.4359	0.4359	0.5761	0
  rs9840460	Imputed	T	ADDITIVE	1.57E−06	1.57E−06	0.4461	0.4461	0.5119	0
  rs9840460	Imputed	T	DOMINANT	1.83E−06	1.83E−06	0.4354	0.4354	0.5792	0
  rs9840756	Imputed	A	ADDITIVE	1.55E−06	1.55E−06	0.4458	0.4458	0.5071	0
  rs9840756	Imputed	A	DOMINANT	1.81E−06	1.81E−06	0.435	0.435	0.5742	0
  rs9844801	Imputed	C	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs985375	Imputed	A	GENOTYPIC	6.39E−05	6.39E−05	2.8891	2.8891	0.9861	0
  rs9869187	Imputed	C	ADDITIVE	7.35E−06	7.35E−06	0.4651	0.4651	0.7004	0
  rs9869187	Imputed	C	DOMINANT	2.02E−05	2.02E−05	0.4704	0.4704	0.6809	0
  rs9872327	Imputed	T	DOMINANT	5.30E−05	8.76E−05	1.9326	1.9381	0.3031	5.72
  rs9881685	Imputed	A	ADDITIVE	1.31E−06	1.31E−06	0.4438	0.4438	0.4978	0
  rs9881685	Imputed	A	DOMINANT	1.61E−06	1.61E−06	0.4332	0.4332	0.5585	0
  rs9909499	Imputed	C	DOMINANT	0.002624	0.002624	1.4669	1.4669	0.7269	0
  rs9911847	Imputed	G	DOMINANT	0.00547	0.00547	0.6755	0.6755	0.9212	0
  rs9946886	Imputed	G	RECESSIVE	5.84E−05	5.84E−05	0.3084	0.3084	0.8937	0
  rs9958823	Imputed	A	ADDITIVE	2.61E−05	2.61E−05	1.5292	1.5292	0.6713	0
  rs9965248	Imputed	T	ADDITIVE	6.66E−05	6.66E−05	1.4965	1.4965	0.6122	0

• TABLE 13
  		ALLELE
  SNP rs #	SOURCE	(A1)	MODEL	P	P(R)	OR	OR(R)	Q	I

  rs198460	Genotyped	G	RECESSIVE	2.05E−06	2.05E−06	1.8108	1.8108	0.5587	0
  rs603940	Genotyped	G	RECESSIVE	7.32E−05	7.32E−05	0.5405	0.5405	0.4588	0
  rs10021016	Genotyped	G	GENOTYPIC	5.48E−05	5.48E−05	2.3945	2.3945	0.8903	0
  rs1003148	Imputed	C	ADDITIVE	1.19E−05	1.19E−05	0.7154	0.7154	0.9106	0
  rs1003148	Imputed	C	GENOTYPIC	8.14E−06	8.14E−06	0.4872	0.4872	0.8101	0
  rs1003148	Imputed	C	RECESSIVE	5.89E−05	5.89E−05	0.5541	0.5541	0.5169	0
  rs10046799	Imputed	C	ADDITIVE	8.59E−05	8.59E−05	0.7444	0.7444	0.3859	0
  rs10046799	Imputed	C	GENOTYPIC	6.10E−05	6.10E−05	0.5427	0.5427	0.4931	0
  rs10051148	Imputed	C	DOMINANT	1.16E−06	1.16E−06	0.596	0.596	0.8669	0
  rs10054055	Imputed	T	DOMINANT	4.36E−07	4.36E−07	0.5814	0.5814	0.9471	0
  rs10067895	Imputed	A	DOMINANT	3.37E−07	3.37E−07	0.5762	0.5762	0.9653	0
  rs1008705	Imputed	C	DOMINANT	9.36E−05	9.36E−05	1.6202	1.6202	0.516	0
  rs10105871	Imputed	C	DOMINANT	9.54E−05	9.54E−05	1.5752	1.5752	0.7598	0
  rs10116807	Imputed	A	GENOTYPIC	2.35E−05	2.35E−05	3.1548	3.1548	0.994	0
  rs10116807	Imputed	A	RECESSIVE	4.72E−05	4.72E−05	2.9802	2.9802	0.9943	0
  rs10121941	Imputed	C	DOMINANT	3.10E−03	1.47E−01	0.6558	0.6652	0.0252	72.84
  rs10128638	Genotyped	G	DOMINANT	7.89E−05	7.89E−05	0.6196	0.6196	0.8513	0
  rs1012924	Imputed	G	ADDITIVE	6.22E−02	5.77E−01	0.7882	0.8017	0.0001	89.23
  rs1012924	Imputed	G	DOMINANT	6.06E−02	0.5529	0.7739	0.7744	0.0001	89.62
  rs1016030	Genotyped	G	ADDITIVE	9.82E−05	9.82E−05	1.3592	1.3592	0.3844	0
  rs1016030	Genotyped	G	GENOTYPIC	0.0001503	0.0001808	1.8631	1.8624	0.3605	1.98
  rs1017558	Imputed	A	RECESSIVE	3.63E−03	0.1741	1.5611	1.5084	0.0227	73.6
  rs10183431	Imputed	T	DOMINANT	1.18E−04	0.0001179	1.5094	1.5094	0.452	0
  rs10195401	Imputed	C	DOMINANT	5.75E−04	0.01653	1.4645	1.4526	0.1484	47.59
  rs10239416	Imputed	A	DOMINANT	8.79E−03	0.3403	0.7512	0.7725	0.0026	83.15
  rs1032188	Imputed	G	GENOTYPIC	3.23E−05	3.23E−05	0.415	0.415	0.4549	0
  rs1032188	Imputed	G	RECESSIVE	4.57E−05	4.57E−05	0.4331	0.4331	0.3757	0
  rs10468988	Imputed	G	ADDITIVE	1.19E−04	0.005354	1.3915	1.3736	0.1822	41.27
  rs10478919	Imputed	G	DOMINANT	3.36E−07	3.36E−07	0.5781	0.5781	0.9145	0
  rs10506623	Imputed	C	DOMINANT	4.11E−05	4.11E−05	0.6355	0.6355	0.7566	0
  rs10506626	Imputed	A	DOMINANT	4.77E−06	4.77E−06	0.6029	0.6029	0.7652	0
  rs10509477	Imputed	T	DOMINANT	5.09E−05	5.09E−05	1.5361	1.5361	0.4725	0
  rs10511071	Imputed	C	DOMINANT	0.003653	0.1786	1.4802	1.4969	0.0084	79.08
  rs10511072	Imputed	G	DOMINANT	3.65E−03	1.79E−01	1.4802	1.4969	0.0084	79.08
  rs10511199	Imputed	C	ADDITIVE	9.12E−04	2.82E−02	1.348	1.3411	0.1188	53.05
  rs10513283	Imputed	G	GENOTYPIC	3.27E−04	1.14E−02	2.7233	2.5889	0.1701	43.55
  rs10520072	Imputed	T	DOMINANT	4.33E−07	4.33E−07	0.5808	0.5808	0.9574	0
  rs1065639	Imputed	C	DOMINANT	5.13E−05	5.13E−05	1.7169	1.7169	0.8785	0
  rs10733846	Imputed	G	ADDITIVE	1.71E−05	5.53E−04	0.6464	0.6552	0.2454	28.81
  rs10733846	Imputed	G	DOMINANT	5.14E−05	5.14E−05	0.6265	0.6265	0.543	0
  rs10737390	Imputed	T	DOMINANT	1.70E−03	0.1499	0.7059	0.7364	0.0305	71.34
  rs10749293	Imputed	G	DOMINANT	1.78E−05	1.78E−05	1.5736	1.5736	0.524	0
  rs10752159	Imputed	G	DOMINANT	7.32E−05	7.32E−05	1.5394	1.5394	0.5089	0
  rs10753760	Imputed	T	ADDITIVE	3.60E−03	0.1365	1.2495	1.2446	0.0275	72.17
  rs10753760	Imputed	T	GENOTYPIC	3.73E−03	0.1448	1.579	1.5661	0.0247	72.99
  rs10757887	Imputed	C	DOMINANT	2.10E−03	0.09341	0.7185	0.7262	0.048	67.07
  rs10758326	Imputed	A	ADDITIVE	3.12E−05	3.12E−05	0.7205	0.7205	0.9344	0
  rs10758326	Imputed	A	GENOTYPIC	1.46E−05	1.46E−05	0.4748	0.4748	0.6437	0
  rs10758326	Imputed	A	RECESSIVE	9.28E−05	9.28E−05	0.5372	0.5372	0.3903	0
  rs10762236	Genotyped	G	ADDITIVE	1.41E−04	1.36E−02	0.6866	0.7015	0.1342	50.22
  rs10765769	Imputed	C	ADDITIVE	1.89E−05	1.89E−05	1.3977	1.3977	0.5396	0
  rs10765769	Imputed	C	GENOTYPIC	4.04E−05	4.04E−05	1.9329	1.9329	0.5283	0
  rs10784891	Imputed	C	ADDITIVE	3.30E−05	3.30E−05	0.7221	0.7221	0.8883	0
  rs10784891	Imputed	C	DOMINANT	3.17E−05	3.17E−05	0.6171	0.6171	0.6062	0
  rs10787923	Imputed	G	DOMINANT	1.17E−05	1.17E−05	1.5929	1.5929	0.4856	0
  rs10787949	Imputed	A	DOMINANT	6.84E−05	6.84E−05	1.5282	1.5282	0.4028	0
  rs10787951	Imputed	G	DOMINANT	7.02E−05	7.02E−05	1.5272	1.5272	0.4	0
  rs10787983	Imputed	C	DOMINANT	5.52E−05	5.52E−05	1.5334	1.5334	0.4235	0
  rs10788380	Imputed	C	ADDITIVE	7.51E−05	7.51E−05	1.3528	1.3528	0.8856	0
  rs10788380	Imputed	C	DOMINANT	3.53E−05	3.53E−05	1.6982	1.6982	0.9632	0
  rs10788380	Imputed	C	GENOTYPIC	6.34E−05	6.34E−05	1.8532	1.8532	0.9102	0
  rs10814418	Imputed	G	DOMINANT	3.49E−03	1.53E−01	0.6592	0.6683	0.0249	72.93
  rs10831417	Imputed	A	ADDITIVE	3.85E−05	3.11E−04	1.3868	1.3856	0.2831	20.76
  rs10831417	Imputed	A	GENOTYPIC	4.55E−05	6.53E−04	1.9715	1.9609	0.2571	26.37
  rs10831422	Imputed	C	ADDITIVE	8.06E−05	8.06E−05	1.366	1.366	0.4125	0
  rs10831422	Imputed	C	GENOTYPIC	6.96E−05	6.96E−05	1.9315	1.9315	0.3829	0
  rs10862931	Imputed	C	GENOTYPIC	5.74E−02	0.5627	0.7112	0.7348	0.0002	88.45
  rs10865197	Imputed	C	DOMINANT	1.16E−04	0.0001158	1.5096	1.5096	0.4518	0
  rs10871302	Imputed	A	DOMINANT	1.00E−04	0.0001	1.6031	1.6031	0.379	0
  rs10877463	Imputed	C	DOMINANT	6.35E−05	6.35E−05	0.6518	0.6518	0.5839	0
  rs10877468	Imputed	C	DOMINANT	7.07E−05	7.07E−05	0.653	0.653	0.5247	0
  rs10879240	Imputed	C	ADDITIVE	3.80E−05	3.80E−05	0.6993	0.6993	0.5299	0
  rs10879242	Imputed	A	DOMINANT	1.18E−05	1.18E−05	0.6	0.6	0.4258	0
  rs10879245	Imputed	G	DOMINANT	1.18E−05	1.18E−05	0.6	0.6	0.4258	0
  rs10879249	Imputed	T	DOMINANT	4.34E−05	4.34E−05	0.6359	0.6359	0.7079	0
  rs10886452	Imputed	A	DOMINANT	5.56E−05	5.56E−05	1.5358	1.5358	0.4242	0
  rs10886463	Imputed	C	DOMINANT	6.07E−05	6.07E−05	1.533	1.533	0.4181	0
  rs10886465	Imputed	A	DOMINANT	7.14E−05	7.14E−05	1.5271	1.5271	0.4344	0
  rs10886526	Imputed	C	DOMINANT	6.05E−05	6.05E−05	1.5311	1.5311	0.4839	0
  rs10902437	Imputed	G	ADDITIVE	6.85E−05	6.85E−05	1.3724	1.3724	0.531	0
  rs10941126	Imputed	G	ADDITIVE	8.37E−03	1.24E−01	0.5451	0.3771	0.0037	82.12
  rs10941126	Imputed	G	DOMINANT	1.51E−02	1.69E−01	0.5356	0.3959	0.0036	82.2
  rs10947871	Imputed	A	DOMINANT	2.83E−05	2.83E−05	1.6668	1.6668	0.5021	0
  rs10972978	Imputed	G	DOMINANT	4.09E−03	0.1884	0.6606	0.6715	0.0152	76.11
  rs10973012	Imputed	A	DOMINANT	3.10E−03	0.1472	0.6558	0.6652	0.0252	72.84
  rs10974028	Genotyped	G	ADDITIVE	6.17E−03	2.38E−01	0.7519	0.7698	0.0127	77.08
  rs10974028	Genotyped	G	DOMINANT	1.85E−03	2.16E−01	0.6916	0.7096	0.0051	81.08
  rs11021302	Imputed	A	ADDITIVE	9.21E−05	9.21E−05	1.3623	1.3623	0.4193	0
  rs11021302	Imputed	A	GENOTYPIC	7.34E−05	7.34E−05	1.9274	1.9274	0.3854	0
  rs11099644	Imputed	G	RECESSIVE	3.63E−03	1.74E−01	1.5611	1.5084	0.0227	73.6
  rs11138315	Imputed	G	ADDITIVE	5.97E−05	5.97E−05	0.6045	0.6045	0.6837	0
  rs11149802	Imputed	T	DOMINANT	1.00E−04	1.00E−04	1.6031	1.6031	0.379	0
  rs1116596	Imputed	T	DOMINANT	3.36E−07	3.36E−07	0.5781	0.5781	0.9145	0
  rs11178531	Imputed	A	ADDITIVE	5.04E−05	5.04E−05	0.7345	0.7345	0.9113	0
  rs11178531	Imputed	A	DOMINANT	1.62E−05	1.62E−05	0.6062	0.6062	0.7273	0
  rs11178575	Imputed	C	GENOTYPIC	7.77E−05	7.77E−05	2.0518	2.0518	0.4613	0
  rs11178575	Imputed	C	RECESSIVE	8.55E−05	8.55E−05	1.9633	1.9633	0.6307	0
  rs11178577	Imputed	T	GENOTYPIC	8.19E−05	8.19E−05	2.0467	2.0467	0.4668	0
  rs11178577	Imputed	T	RECESSIVE	8.45E−05	8.45E−05	1.9643	1.9643	0.6423	0
  rs11178583	Imputed	A	DOMINANT	3.48E−05	3.48E−05	0.6311	0.6311	0.6157	0
  rs11178589	Imputed	T	DOMINANT	6.58E−05	6.58E−05	0.6416	0.6416	0.759	0
  rs11178594	Imputed	C	DOMINANT	2.21E−05	2.21E−05	0.6259	0.6259	0.7529	0
  rs11178602	Imputed	T	DOMINANT	1.96E−05	1.96E−05	0.6239	0.6239	0.7278	0
  rs11178648	Imputed	T	DOMINANT	4.60E−06	4.60E−06	0.6044	0.6044	0.7746	0
  rs11198877	Imputed	T	DOMINANT	5.89E−05	5.89E−05	1.5335	1.5335	0.418	0
  rs11198942	Imputed	T	DOMINANT	4.04E−05	4.04E−05	1.5455	1.5455	0.4358	0
  rs11221075	Imputed	A	ADDITIVE	4.74E−05	4.74E−05	0.6113	0.6113	0.5392	0
  rs11242020	Imputed	T	DOMINANT	2.55E−07	2.55E−07	0.5746	0.5746	0.9225	0
  rs11242021	Imputed	T	DOMINANT	4.26E−07	4.26E−07	0.5804	0.5804	0.9558	0
  rs11242022	Imputed	T	DOMINANT	5.79E−07	5.79E−07	0.5841	0.5841	0.9318	0
  rs11242023	Imputed	T	DOMINANT	5.92E−07	5.92E−07	0.5843	0.5843	0.9496	0
  rs1149350	Imputed	A	DOMINANT	2.45E−03	1.30E−01	1.3997	1.3907	0.0257	72.68
  rs1150143	Imputed	G	DOMINANT	6.34E−04	3.31E−02	1.4503	1.4366	0.0937	57.77
  rs11576627	Imputed	T	ADDITIVE	4.22E−05	4.22E−05	1.5665	1.5665	0.6281	0
  rs11576627	Imputed	T	DOMINANT	3.05E−05	3.05E−05	1.6676	1.6676	0.7461	0
  rs11602189	Imputed	A	DOMINANT	1.82E−04	0.001317	0.6717	0.6744	0.2718	23.24
  rs11605163	Imputed	A	DOMINANT	0.000708	0.02749	1.6562	1.6712	0.0948	57.56
  rs11615214	Imputed	G	ADDITIVE	5.75E−06	5.75E−06	0.7047	0.7047	0.5765	0
  rs11615214	Imputed	G	GENOTYPIC	2.91E−06	2.91E−06	0.4566	0.4566	0.4781	0
  rs11642394	Imputed	C	DOMINANT	9.69E−05	9.69E−05	1.6046	1.6046	0.3847	0
  rs11644943	Imputed	A	ADDITIVE	6.34E−05	6.34E−05	1.4362	1.4362	0.687	0
  rs11656608	Imputed	T	DOMINANT	5.19E−05	5.19E−05	0.6191	0.6191	0.5685	0
  rs11661309	Imputed	A	ADDITIVE	3.44E−05	3.44E−05	0.6656	0.6656	0.471	0
  rs11661309	Imputed	A	DOMINANT	2.13E−04	8.96E−04	0.6556	0.657	0.2991	17.16
  rs11666131	Imputed	A	ADDITIVE	3.25E−04	6.19E−03	1.3849	1.3772	0.1964	38.55
  rs11743355	Imputed	C	ADDITIVE	1.07E−02	1.27E−01	0.5495	0.3573	0.0028	82.99
  rs11743355	Imputed	C	DOMINANT	1.87E−02	1.70E−01	0.5389	0.3746	0.0027	83.11
  rs11746806	Imputed	T	ADDITIVE	8.22E−03	0.1202	0.5498	0.3996	0.0061	80.4
  rs11746806	Imputed	T	DOMINANT	1.56E−02	1.68E−01	0.5436	0.4204	0.006	80.44
  rs11746959	Imputed	T	ADDITIVE	8.37E−03	1.24E−01	0.5451	0.3771	0.0037	82.12
  rs11746959	Imputed	T	DOMINANT	1.51E−02	1.69E−01	0.5356	0.3959	0.0036	82.2
  rs11749272	Imputed	T	DOMINANT	3.75E−07	3.75E−07	0.5789	0.5789	0.9197	0
  rs11901899	Imputed	A	DOMINANT	5.05E−05	5.05E−05	1.5436	1.5436	0.6491	0
  rs11926319	Imputed	G	ADDITIVE	2.62E−05	3.51E−02	0.5502	0.5519	0.0242	73.13
  rs11926319	Imputed	G	DOMINANT	4.50E−05	0.04527	0.5488	0.5505	0.0199	74.48
  rs11956952	Imputed	C	DOMINANT	8.97E−05	8.97E−05	0.6544	0.6544	0.9288	0
  rs12025826	Imputed	G	DOMINANT	9.61E−05	9.61E−05	1.5444	1.5444	0.6337	0
  rs1204522	Imputed	C	GENOTYPIC	1.76E−03	0.09323	0.5754	0.5955	0.0532	65.92
  rs1204524	Imputed	A	GENOTYPIC	1.75E−03	0.09548	0.5752	0.5962	0.0519	66.2
  rs12153185	Imputed	T	DOMINANT	3.02E−07	3.02E−07	0.575	0.575	0.965	0
  rs12182651	Imputed	T	ADDITIVE	4.03E−04	6.63E−02	1.6379	1.6775	0.0204	74.32
  rs12182651	Imputed	T	DOMINANT	9.90E−05	0.06125	1.8091	1.8433	0.0126	77.13
  rs12193568	Imputed	G	DOMINANT	5.33E−05	5.33E−05	1.7043	1.7043	0.4515	0
  rs12264914	Imputed	C	DOMINANT	9.89E−05	9.89E−05	0.5796	0.5796	0.4664	0
  rs12307767	Imputed	C	DOMINANT	7.20E−05	7.20E−05	0.6476	0.6476	0.5868	0
  rs1232298	Imputed	G	RECESSIVE	4.05E−05	4.05E−05	2.0359	2.0359	0.4524	0
  rs12407412	Imputed	C	ADDITIVE	4.22E−05	4.22E−05	1.5665	1.5665	0.6281	0
  rs12407412	Imputed	C	DOMINANT	3.05E−05	3.05E−05	1.6676	1.6676	0.7461	0
  rs12420184	Imputed	G	DOMINANT	1.51E−02	0.4077	0.7481	0.7745	0.0016	84.53
  rs12422750	Imputed	A	DOMINANT	9.60E−05	9.60E−05	0.6598	0.6598	0.5137	0
  rs12446951	Imputed	A	ADDITIVE	3.93E−05	1.09E−04	2.0253	2.0349	0.3226	11.62
  rs12446951	Imputed	A	DOMINANT	4.82E−05	4.82E−05	2.049	2.049	0.3973	0
  rs12457400	Imputed	G	DOMINANT	7.89E−05	7.89E−05	0.5854	0.5854	0.8723	0
  rs1247340	Imputed	C	DOMINANT	2.05E−03	0.1157	1.4086	1.4002	0.0296	71.6
  rs1247341	Imputed	C	DOMINANT	1.57E−03	1.02E−01	1.4213	1.4156	0.0312	71.17
  rs12521291	Imputed	G	ADDITIVE	1.87E−03	1.09E−01	0.7805	0.7921	0.04	68.92
  rs12526849	Imputed	T	ADDITIVE	7.17E−04	0.03214	1.2878	1.2722	0.1105	54.59
  rs12526849	Imputed	T	GENOTYPIC	3.38E−04	5.04E−03	1.7306	1.7075	0.2173	34.49
  rs12543110	Imputed	G	DOMINANT	5.89E−05	5.89E−05	1.5358	1.5358	0.5248	0
  rs12678600	Imputed	A	DOMINANT	1.00E−04	1.00E−04	0.6602	0.6602	0.5151	0
  rs12719415	Imputed	T	DOMINANT	2.53E−07	2.53E−07	0.5739	0.5739	0.9166	0
  rs12831292	Imputed	G	DOMINANT	2.63E−05	2.63E−05	0.6278	0.6278	0.7312	0
  rs12923993	Imputed	C	DOMINANT	9.69E−05	9.69E−05	1.6046	1.6046	0.3847	0
  rs12936964	Imputed	T	DOMINANT	3.11E−04	2.93E−03	1.4884	1.4756	0.2539	27.04
  rs12960663	Imputed	G	ADDITIVE	4.89E−05	4.89E−05	0.6695	0.6695	0.515	0
  rs13038146	Imputed	C	ADDITIVE	3.11E−05	3.11E−05	1.376	1.376	0.9378	0
  rs13038146	Imputed	C	GENOTYPIC	2.11E−05	2.11E−05	2.0071	2.0071	0.9192	0
  rs13134222	Imputed	A	GENOTYPIC	1.96E−02	3.26E−01	0.5583	0.5463	0.0028	82.95
  rs13172910	Imputed	A	DOMINANT	7.00E−05	7.00E−05	0.6505	0.6505	0.9366	0
  rs13194907	Imputed	A	ADDITIVE	0.0002176	0.02467	1.7666	1.7835	0.0668	63.04
  rs13194907	Imputed	A	DOMINANT	6.05E−05	0.01168	1.9281	1.9369	0.0827	59.88
  rs13195745	Imputed	A	ADDITIVE	2.18E−04	2.47E−02	1.7666	1.7835	0.0668	63.04
  rs13195745	Imputed	A	DOMINANT	6.05E−05	1.17E−02	1.9281	1.9369	0.0827	59.88
  rs1321432	Imputed	A	RECESSIVE	8.48E−04	0.08213	1.6508	1.6057	0.0423	68.39
  rs1321457	Imputed	G	RECESSIVE	0.001376	0.1001	1.6314	1.5668	0.0465	67.4
  rs13265054	Imputed	T	DOMINANT	6.52E−05	6.52E−05	0.6518	0.6518	0.6806	0
  rs13282131	Imputed	C	GENOTYPIC	6.27E−05	6.27E−05	1.8345	1.8345	0.9895	0
  rs13353526	Imputed	C	DOMINANT	0.004081	0.1849	1.4667	1.4829	0.0079	79.32
  rs1336382	Imputed	T	DOMINANT	5.09E−05	5.09E−05	1.5361	1.5361	0.4725	0
  rs1336383	Imputed	T	DOMINANT	5.09E−05	5.09E−05	1.5361	1.5361	0.4725	0
  rs1336407	Imputed	T	DOMINANT	5.93E−05	5.93E−05	1.5308	1.5308	0.4544	0
  rs1336409	Imputed	T	DOMINANT	6.50E−05	6.50E−05	1.5274	1.5274	0.444	0
  rs1336596	Imputed	A	DOMINANT	5.26E−04	3.65E−02	0.6858	0.7027	0.0985	56.85
  rs1343560	Imputed	T	ADDITIVE	6.41E−02	5.75E−01	0.7895	0.8024	0.0001	89.05
  rs1343560	Imputed	T	DOMINANT	6.21E−02	5.51E−01	0.775	0.7751	0.0001	89.44
  rs1361987	Imputed	T	GENOTYPIC	2.87E−03	1.52E−01	0.5945	0.6201	0.0307	71.3
  rs1386153	Imputed	T	ADDITIVE	0.0001163	0.0001163	0.7313	0.7313	0.4314	0
  rs1386153	Imputed	T	DOMINANT	0.0001226	0.0004692	0.6655	0.6672	0.3089	14.88
  rs1394015	Imputed	C	DOMINANT	4.04E−05	4.04E−05	1.7398	1.7398	0.8288	0
  rs1407038	Imputed	A	RECESSIVE	1.15E−03	0.09526	1.6392	1.5778	0.0445	67.86
  rs1407039	Imputed	A	RECESSIVE	1.54E−03	0.08002	1.6009	1.5561	0.0626	63.92
  rs1412802	Imputed	T	GENOTYPIC	9.49E−05	9.49E−05	0.4269	0.4269	0.9393	0
  rs1414865	Imputed	T	DOMINANT	6.84E−05	6.84E−05	1.5282	1.5282	0.4028	0
  rs1414873	Imputed	A	DOMINANT	5.05E−05	5.05E−05	1.5365	1.5365	0.433	0
  rs1414876	Imputed	C	DOMINANT	5.05E−05	5.05E−05	1.5365	1.5365	0.433	0
  rs1418671	Imputed	C	RECESSIVE	8.77E−05	1.17E−02	1.79	1.752	0.1097	54.76
  rs1419490	Genotyped	T	GENOTYPIC	1.69E−03	1.04E−01	0.5757	0.6036	0.051	66.41
  rs1434507	Imputed	A	ADDITIVE	3.80E−04	1.15E−02	1.3574	1.3388	0.175	42.63
  rs1434508	Imputed	T	ADDITIVE	4.60E−04	1.09E−02	1.3515	1.3341	0.1863	40.49
  rs1435205	Imputed	A	ADDITIVE	9.12E−04	2.82E−02	1.348	1.3411	0.1188	53.05
  rs1443928	Imputed	C	RECESSIVE	9.45E−04	4.30E−02	0.6717	0.6702	0.0739	61.62
  rs1452235	Imputed	G	GENOTYPIC	5.06E−02	5.71E−01	0.7054	0.7381	0.0001	88.72
  rs1452236	Imputed	G	GENOTYPIC	4.94E−02	5.70E−01	0.7041	0.7369	0.0001	88.77
  rs1452237	Imputed	G	GENOTYPIC	5.06E−02	5.71E−01	0.7054	0.7381	0.0001	88.72
  rs1452243	Genotyped	T	GENOTYPIC	5.39E−02	5.77E−01	0.7092	0.7402	0.0001	88.89
  rs1463768	Genotyped	G	RECESSIVE	2.87E−05	3.63E−05	1.813	1.8163	0.3578	2.71
  rs1463769	Imputed	G	RECESSIVE	2.08E−05	2.08E−05	1.8336	1.8336	0.3916	0
  rs1472435	Imputed	A	ADDITIVE	4.20E−05	4.20E−05	0.5101	0.5101	0.5038	0
  rs1472435	Imputed	A	DOMINANT	8.16E−05	8.16E−05	0.5146	0.5146	0.4725	0
  rs1476714	Imputed	A	DOMINANT	3.69E−07	3.69E−07	0.5781	0.5781	0.9536	0
  rs1495159	Imputed	G	ADDITIVE	0.009749	0.3924	0.8068	0.8189	0.0005	86.97
  rs1495159	Imputed	G	GENOTYPIC	3.08E−03	1.34E−01	0.5615	0.5708	0.0278	72.1
  rs1495375	Imputed	A	DOMINANT	3.20E−05	3.20E−05	0.6273	0.6273	0.709	0
  rs1495376	Imputed	T	DOMINANT	2.76E−05	3.75E−04	0.5966	0.5952	0.2528	27.28
  rs1495377	Imputed	G	DOMINANT	5.28E−05	0.0006669	0.6086	0.6065	0.2463	28.63
  rs1495381	Imputed	T	GENOTYPIC	1.97E−05	1.97E−05	1.9868	1.9868	0.6544	0
  rs1495381	Imputed	T	RECESSIVE	3.14E−06	3.14E−06	1.9704	1.9704	0.904	0
  rs1498992	Imputed	G	DOMINANT	4.91E−05	4.91E−05	0.6496	0.6496	0.6335	0
  rs1499001	Imputed	T	DOMINANT	9.99E−05	9.99E−05	0.6588	0.6588	0.5929	0
  rs1512988	Imputed	A	DOMINANT	3.15E−05	3.15E−05	0.6309	0.6309	0.7406	0
  rs1512989	Imputed	T	DOMINANT	3.15E−05	3.15E−05	0.6309	0.6309	0.7406	0
  rs1512991	Imputed	T	ADDITIVE	4.36E−05	4.36E−05	0.7304	0.7304	0.9674	0
  rs1512991	Imputed	T	DOMINANT	2.35E−05	2.35E−05	0.6133	0.6133	0.7725	0
  rs1516855	Imputed	G	RECESSIVE	2.16E−04	3.15E−03	1.8266	1.832	0.214	35.15
  rs1527450	Imputed	T	ADDITIVE	4.98E−05	0.0004174	1.3805	1.3796	0.2782	21.84
  rs1527450	Imputed	T	GENOTYPIC	5.39E−05	0.0005959	1.9591	1.9507	0.2671	24.24
  rs1567740	Imputed	T	DOMINANT	3.10E−05	3.10E−05	0.6303	0.6303	0.7208	0
  rs1572573	Imputed	A	ADDITIVE	2.29E−04	0.04251	1.4476	1.3911	0.0856	59.31
  rs1572573	Imputed	A	DOMINANT	9.40E−05	4.64E−02	1.562	1.5083	0.0429	68.24
  rs1584003	Imputed	C	DOMINANT	3.34E−02	0.561	1.2949	1.2466	0.0001	89.29
  rs1584005	Imputed	C	DOMINANT	4.02E−02	5.68E−01	1.2838	1.2385	0.0001	89
  rs1585771	Imputed	G	ADDITIVE	1.04E−03	0.04355	1.3199	1.3042	0.0982	56.91
  rs1592015	Imputed	G	DOMINANT	0.002751	0.1964	0.7042	0.7334	0.018	75.11
  rs1594885	Imputed	A	ADDITIVE	0.000164	0.004814	1.3801	1.3638	0.201	37.68
  rs1603232	Imputed	A	DOMINANT	6.82E−05	7.72E−05	0.6125	0.6124	0.3627	1.4
  rs1614565	Imputed	C	DOMINANT	1.67E−05	2.91E−05	0.5932	0.5932	0.3482	5.22
  rs1648200	Imputed	G	ADDITIVE	9.92E−05	9.92E−05	1.428	1.428	0.791	0
  rs16877387	Imputed	C	GENOTYPIC	5.85E−04	2.88E−02	1.7999	1.7462	0.1152	53.73
  rs16877387	Imputed	C	RECESSIVE	1.06E−04	0.00243	1.8666	1.8409	0.2165	34.65
  rs16938626	Imputed	G	DOMINANT	6.97E−05	6.97E−05	0.6537	0.6537	0.5901	0
  rs1694334	Imputed	G	ADDITIVE	3.41E−03	1.76E−01	0.7552	0.7708	0.0228	73.54
  rs16998821	Imputed	C	DOMINANT	2.75E−03	1.96E−01	0.7042	0.7334	0.018	75.11
  rs1700400	Imputed	T	ADDITIVE	2.87E−04	1.62E−02	0.7267	0.7259	0.1095	54.78
  rs17007620	Imputed	G	ADDITIVE	0.0002711	0.02062	1.4055	1.3946	0.0989	56.78
  rs17007620	Imputed	G	DOMINANT	0.0001384	0.003404	1.5358	1.5258	0.1998	37.9
  rs17023290	Imputed	C	DOMINANT	0.003653	0.1786	1.4802	1.4969	0.0084	79.08
  rs17047957	Imputed	C	DOMINANT	2.41E−05	2.41E−05	1.6313	1.6313	0.7603	0
  rs1705237	Imputed	A	DOMINANT	1.23E−05	3.98E−05	0.5877	0.5877	0.326	10.78
  rs1705261	Imputed	A	GENOTYPIC	2.16E−05	2.16E−05	1.9729	1.9729	0.7039	0
  rs1705261	Imputed	A	RECESSIVE	3.71E−06	3.71E−06	1.9521	1.9521	0.9207	0
  rs17076972	Imputed	C	ADDITIVE	0.0005241	0.01788	1.2997	1.2903	0.1408	48.99
  rs17076972	Imputed	C	GENOTYPIC	0.0004395	0.02097	1.7025	1.6732	0.1233	52.23
  rs17076972	Imputed	C	RECESSIVE	7.62E−04	4.50E−02	1.5342	1.5023	0.0868	59.08
  rs17189710	Imputed	T	ADDITIVE	3.68E−05	3.68E−05	1.3739	1.3739	0.9395	0
  rs17189710	Imputed	T	GENOTYPIC	2.19E−05	2.19E−05	2.0119	2.0119	0.9089	0
  rs17196143	Imputed	A	ADDITIVE	1.68E−02	4.65E−01	1.2599	1.2043	0.0013	84.9
  rs17353809	Imputed	G	ADDITIVE	7.94E−04	4.73E−02	1.3563	1.3441	0.0746	61.48
  rs17368986	Imputed	A	GENOTYPIC	0.0003311	0.01194	2.721	2.5843	0.1676	44.02
  rs17369097	Imputed	A	GENOTYPIC	2.42E−04	1.85E−03	2.7571	2.7036	0.2673	24.2
  rs17434511	Imputed	C	GENOTYPIC	0.0003164	0.0117	2.7302	2.5932	0.1672	44.1
  rs17434589	Imputed	C	GENOTYPIC	0.0002946	0.01171	2.7449	2.6054	0.1643	44.62
  rs17434603	Imputed	G	GENOTYPIC	0.0003271	0.01143	2.7233	2.5889	0.1701	43.55
  rs17434840	Imputed	C	GENOTYPIC	0.0002417	0.001846	2.7571	2.7036	0.2673	24.2
  rs17446418	Imputed	G	DOMINANT	0.0005194	0.08804	0.6822	0.714	0.0469	67.33
  rs17530747	Imputed	T	DOMINANT	0.0003577	0.0827	0.6735	0.7062	0.0438	68.03
  rs17604285	Imputed	C	ADDITIVE	0.0001077	0.01983	0.5857	0.5921	0.0823	59.95
  rs17604285	Imputed	C	DOMINANT	0.0001272	0.02188	0.5769	0.5823	0.0746	61.48
  rs17662322	Imputed	T	DOMINANT	8.83E−05	8.83E−05	0.6424	0.6424	0.4888	0
  rs17769826	Imputed	T	ADDITIVE	0.0008578	0.04731	1.3535	1.3419	0.0766	61.08
  rs17821641	Imputed	T	ADDITIVE	0.0009123	0.02815	1.348	1.3411	0.1188	53.05
  rs1782328	Imputed	A	ADDITIVE	0.0002285	0.0184	0.687	0.6954	0.116	53.58
  rs1796337	Imputed	T	DOMINANT	5.74E−05	5.74E−05	0.6075	0.6075	0.7452	0
  rs1798083	Imputed	C	DOMINANT	2.91E−05	2.91E−05	0.602	0.602	0.3963	0
  rs1798085	Imputed	T	DOMINANT	1.95E−05	3.15E−05	0.5952	0.5951	0.3506	4.59
  rs1798086	Imputed	T	DOMINANT	8.08E−06	1.64E−05	0.5778	0.5781	0.3453	5.95
  rs1798089	Imputed	C	GENOTYPIC	9.52E−05	9.52E−05	2.0099	2.0099	0.7968	0
  rs1798089	Imputed	C	RECESSIVE	1.73E−05	1.73E−05	1.9885	1.9885	0.8721	0
  rs1798090	Imputed	C	GENOTYPIC	8.44E−05	8.44E−05	2.0204	2.0204	0.8325	0
  rs1798090	Imputed	C	RECESSIVE	2.27E−05	2.27E−05	1.9652	1.9652	0.894	0
  rs1832222	Imputed	G	DOMINANT	5.87E−05	5.87E−05	1.5311	1.5311	0.4163	0
  rs1838104	Imputed	A	ADDITIVE	0.0002117	0.003729	0.7525	0.7527	0.2031	37.26
  rs1838104	Imputed	A	GENOTYPIC	0.0002138	0.002807	0.5646	0.5645	0.2213	33.7
  rs1868616	Imputed	G	ADDITIVE	7.48E−05	0.0004629	0.6753	0.6791	0.2929	18.56
  rs1874313	Imputed	A	DOMINANT	3.30E−05	3.30E−05	0.6312	0.6312	0.6562	0
  rs1884902	Imputed	C	RECESSIVE	0.001151	0.07621	1.6251	1.5839	0.0555	65.41
  rs1913201	Imputed	G	ADDITIVE	1.89E−05	1.89E−05	0.7164	0.7164	0.8808	0
  rs1913201	Imputed	G	DOMINANT	2.91E−05	2.91E−05	0.6172	0.6172	0.7641	0
  rs1913201	Imputed	G	GENOTYPIC	7.80E−05	7.80E−05	0.5351	0.5351	0.6861	0
  rs1944279	Imputed	A	ADDITIVE	0.0001257	0.005478	1.3904	1.3724	0.1829	41.13
  rs198461	Imputed	C	DOMINANT	1.66E−06	1.66E−06	0.5498	0.5498	0.6534	0
  rs1987179	Imputed	T	DOMINANT	7.08E−05	7.08E−05	0.641	0.641	0.5343	0
  rs1990023	Imputed	T	DOMINANT	2.55E−07	2.55E−07	0.5746	0.5746	0.9225	0
  rs2016194	Imputed	G	DOMINANT	4.26E−07	4.26E−07	0.5804	0.5804	0.9558	0
  rs2024789	Imputed	C	ADDITIVE	0.0008551	0.04722	0.7786	0.789	0.0866	59.13
  rs2024789	Imputed	C	GENOTYPIC	0.001077	0.04627	0.6104	0.625	0.0938	57.75
  rs2024902	Imputed	A	ADDITIVE	0.0004002	0.02334	1.7111	1.7273	0.0887	58.72
  rs2024902	Imputed	A	DOMINANT	9.43E−05	0.01112	1.8804	1.8895	0.0981	56.93
  rs2025107	Imputed	A	ADDITIVE	0.0005021	0.06161	1.6166	1.6531	0.0272	72.27
  rs2025107	Imputed	A	DOMINANT	0.0001126	0.05784	1.7901	1.8228	0.0156	75.95
  rs2025108	Imputed	T	ADDITIVE	0.0005021	0.06161	1.6166	1.6531	0.0272	72.27
  rs2025108	Imputed	T	DOMINANT	0.0001126	0.05784	1.7901	1.8228	0.0156	75.95
  rs2062448	Imputed	T	ADDITIVE	0.0001197	0.0124	0.5855	0.5897	0.1132	54.1
  rs2062448	Imputed	T	DOMINANT	0.0001438	0.01375	0.5765	0.5801	0.1057	55.5
  rs2063591	Imputed	C	ADDITIVE	6.31E−05	6.31E−05	0.7382	0.7382	0.9476	0
  rs2063591	Imputed	C	DOMINANT	1.50E−05	1.50E−05	0.6047	0.6047	0.7317	0
  rs2065604	Imputed	C	DOMINANT	0.003098	0.1472	0.6558	0.6652	0.0252	72.84
  rs2066238	Imputed	T	DOMINANT	0.00258	0.1967	0.7027	0.7323	0.0172	75.39
  rs2068051	Imputed	G	ADDITIVE	0.0001657	0.004859	0.6917	0.7008	0.2023	37.41
  rs2068051	Imputed	G	GENOTYPIC	0.0002673	0.007654	0.4817	0.4968	0.1931	39.2
  rs2077702	Genotyped	G	GENOTYPIC	9.79E−05	9.79E−05	2.0248	2.0248	0.5151	0
  rs208757	Imputed	G	ADDITIVE	4.49E−05	4.49E−05	1.5013	1.5013	0.8401	0
  rs208757	Imputed	G	DOMINANT	9.41E−06	9.41E−06	1.6603	1.6603	0.7321	0
  rs2095586	Imputed	A	DOMINANT	5.72E−05	5.72E−05	1.532	1.532	0.4194	0
  rs2108426	Imputed	C	DOMINANT	4.02E−07	4.02E−07	0.5797	0.5797	0.9591	0
  rs2110664	Imputed	A	DOMINANT	8.67E−05	8.67E−05	1.5394	1.5394	0.8744	0
  rs2132242	Imputed	A	DOMINANT	2.72E−05	2.72E−05	0.6282	0.6282	0.7958	0
  rs2151644	Imputed	T	DOMINANT	0.003131	0.1517	0.656	0.6657	0.0236	73.31
  rs2157752	Genotyped	A	GENOTYPIC	0.0009168	0.05016	0.5431	0.5628	0.0902	58.44
  rs2158958	Imputed	A	DOMINANT	4.20E−07	4.20E−07	0.5804	0.5804	0.9556	0
  rs2158961	Imputed	G	DOMINANT	1.33E−06	1.33E−06	0.5977	0.5977	0.8737	0
  rs2164099	Imputed	G	ADDITIVE	0.0001863	0.006344	1.376	1.3584	0.1883	40.11
  rs2173254	Imputed	G	GENOTYPIC	0.002362	0.118	0.5447	0.533	0.0217	73.89
  rs2173254	Imputed	G	RECESSIVE	0.002217	0.0789	0.5578	0.5403	0.042	68.46
  rs2188079	Imputed	C	ADDITIVE	0.0001838	0.02268	1.3319	1.321	0.0862	59.19
  rs2188079	Imputed	C	GENOTYPIC	0.0001122	0.0128	1.8273	1.7987	0.1109	54.53
  rs2190304	Imputed	G	RECESSIVE	0.01058	0.4116	0.7116	0.7366	0.0005	86.94
  rs2190597	Imputed	T	DOMINANT	9.78E−05	9.78E−05	0.6395	0.6395	0.4926	0
  rs2190598	Imputed	T	DOMINANT	4.20E−07	4.20E−07	0.5804	0.5804	0.9556	0
  rs2190600	Imputed	A	DOMINANT	3.37E−07	3.37E−07	0.5762	0.5762	0.9653	0
  rs2218084	Imputed	T	GENOTYPIC	9.58E−05	9.58E−05	3.531	3.531	0.7772	0
  rs2218084	Imputed	T	RECESSIVE	8.93E−05	8.93E−05	3.5234	3.5234	0.8908	0
  rs2236290	Genotyped	C	GENOTYPIC	6.42E−05	6.42E−05	0.4993	0.4993	0.9011	0
  rs2243860	Imputed	A	GENOTYPIC	7.41E−05	7.41E−05	2.0648	2.0648	0.8032	0
  rs2243860	Imputed	A	RECESSIVE	8.56E−05	8.56E−05	1.9204	1.9204	0.6639	0
  rs2246564	Imputed	T	DOMINANT	0.003098	0.1472	0.6558	0.6652	0.0252	72.84
  rs2248236	Imputed	C	DOMINANT	7.76E−05	7.76E−05	0.6498	0.6498	0.545	0
  rs2250340	Imputed	T	DOMINANT	0.003303	0.1528	0.6523	0.6609	0.0229	73.54
  rs2257192	Imputed	G	DOMINANT	0.003098	0.1472	0.6558	0.6652	0.0252	72.84
  rs2270584	Imputed	A	DOMINANT	4.80E−06	4.80E−06	0.605	0.605	0.7982	0
  rs2270586	Imputed	A	DOMINANT	5.31E−06	5.31E−06	0.6041	0.6041	0.7347	0
  rs2270589	Imputed	A	ADDITIVE	2.81E−06	2.81E−06	0.6877	0.6877	0.8813	0
  rs2270589	Imputed	A	DOMINANT	2.60E−07	2.60E−07	0.5336	0.5336	0.71	0
  rs2270589	Imputed	A	GENOTYPIC	1.28E−05	1.28E−05	0.4977	0.4977	0.7794	0
  rs2296889	Imputed	C	DOMINANT	0.002588	0.1138	1.4232	1.4076	0.0374	69.56
  rs2301346	Imputed	C	ADDITIVE	0.0002178	0.0338	1.3978	1.3772	0.0701	62.37
  rs2301346	Imputed	C	DOMINANT	0.0001352	0.02587	1.5644	1.5455	0.0672	62.97
  rs2327929	Imputed	G	RECESSIVE	1.06E−05	1.06E−05	1.7928	1.7928	0.4369	0
  rs2357486	Imputed	C	RECESSIVE	0.00295	0.1854	1.7126	1.6148	0.024	73.18
  rs2373793	Imputed	G	DOMINANT	4.57E−05	4.57E−05	1.617	1.617	0.8752	0
  rs2377622	Imputed	T	GENOTYPIC	2.11E−05	2.11E−05	0.3896	0.3896	0.7037	0
  rs2377622	Imputed	T	RECESSIVE	2.44E−05	2.44E−05	0.4115	0.4115	0.6397	0
  rs2383903	Imputed	G	DOMINANT	3.69E−05	3.69E−05	0.645	0.645	0.6185	0
  rs2389866	Imputed	C	DOMINANT	4.60E−05	4.60E−05	0.6408	0.6408	0.6066	0
  rs2389869	Imputed	C	DOMINANT	4.60E−05	4.60E−05	0.6408	0.6408	0.6066	0
  rs2418541	Imputed	A	DOMINANT	3.36E−07	3.36E−07	0.5781	0.5781	0.9145	0
  rs2418542	Imputed	A	DOMINANT	3.36E−07	3.36E−07	0.5781	0.5781	0.9145	0
  rs2418548	Imputed	C	DOMINANT	2.36E−06	2.36E−06	0.598	0.598	0.9168	0
  rs2476976	Imputed	C	DOMINANT	7.42E−05	7.42E−05	1.5229	1.5229	0.5546	0
  rs2483639	Imputed	A	DOMINANT	0.003098	0.1472	0.6558	0.6652	0.0252	72.84
  rs2483640	Imputed	A	DOMINANT	0.003098	0.1472	0.6558	0.6652	0.0252	72.84
  rs2544780	Imputed	T	RECESSIVE	7.90E−05	7.90E−05	2.0334	2.0334	0.4674	0
  rs2586458	Imputed	T	DOMINANT	0.03011	0.336	0.7195	0.6895	0.0016	84.47
  rs2593272	Imputed	G	ADDITIVE	0.0002545	0.004989	0.7307	0.7296	0.1874	40.27
  rs2593273	Imputed	T	ADDITIVE	0.0005623	0.03	0.7408	0.7417	0.0868	59.09
  rs2622499	Imputed	G	DOMINANT	9.25E−05	9.25E−05	0.6531	0.6531	0.5221	0
  rs264126	Imputed	C	DOMINANT	8.31E−05	8.31E−05	0.6369	0.6369	0.4319	0
  rs264129	Imputed	T	DOMINANT	1.21E−06	1.21E−06	0.5966	0.5966	0.8652	0
  rs2656822	Imputed	T	ADDITIVE	0.0002545	0.004989	0.7307	0.7296	0.1874	40.27
  rs2656823	Imputed	G	ADDITIVE	0.0002545	0.004989	0.7307	0.7296	0.1874	40.27
  rs2656825	Imputed	T	ADDITIVE	0.0008702	0.04621	0.7415	0.7347	0.0581	64.86
  rs2764766	Imputed	C	RECESSIVE	8.08E−05	8.08E−05	2.0146	2.0146	0.461	0
  rs2793101	Imputed	T	ADDITIVE	0.001506	0.1134	0.6664	0.691	0.0408	68.75
  rs2793101	Imputed	T	DOMINANT	0.001377	0.07663	0.6498	0.6704	0.0666	63.09
  rs2795871	Imputed	A	ADDITIVE	7.48E−05	7.48E−05	0.5195	0.5195	0.5044	0
  rs2795886	Imputed	A	ADDITIVE	4.74E−05	4.74E−05	0.4603	0.4603	0.6122	0
  rs2795886	Imputed	A	DOMINANT	7.68E−05	7.68E−05	0.4623	0.4623	0.6008	0
  rs2859994	Imputed	C	GENOTYPIC	0.001111	0.04898	1.7472	1.7054	0.0857	59.3
  rs2870464	Imputed	G	DOMINANT	9.42E−05	9.42E−05	1.6183	1.6183	0.5381	0
  rs2875528	Imputed	T	DOMINANT	0.00249	0.1329	1.4996	1.5256	0.0141	76.54
  rs2876227	Imputed	C	ADDITIVE	2.20E−05	2.20E−05	1.3926	1.3926	0.9997	0
  rs2876227	Imputed	C	GENOTYPIC	1.68E−05	1.68E−05	2.0556	2.0556	0.8801	0
  rs2882097	Imputed	A	DOMINANT	5.09E−05	5.09E−05	1.5361	1.5361	0.4725	0
  rs2921983	Imputed	C	ADDITIVE	0.0001118	0.003732	0.7041	0.7047	0.1767	42.31
  rs2987537	Imputed	C	DOMINANT	0.03897	0.4969	0.7689	0.776	0.0002	88.03
  rs2996416	Imputed	C	ADDITIVE	0.0637	0.5796	0.7893	0.8032	0.0001	89.2
  rs2996416	Imputed	C	DOMINANT	0.06194	0.5554	0.775	0.7758	0.0001	89.6
  rs3015527	Imputed	C	ADDITIVE	0.07495	0.6564	0.7934	0.8312	0.0001	89.8
  rs3015527	Imputed	C	DOMINANT	0.07947	0.6402	0.7832	0.8084	0	90.3
  rs3015530	Imputed	C	ADDITIVE	0.06224	0.577	0.7882	0.8017	0.0001	89.23
  rs3015530	Imputed	C	DOMINANT	0.06057	0.5529	0.7739	0.7744	0.0001	89.62
  rs3015531	Imputed	T	ADDITIVE	0.06224	0.577	0.7882	0.8017	0.0001	89.23
  rs3015531	Imputed	T	DOMINANT	0.06057	0.5529	0.7739	0.7744	0.0001	89.62
  rs3015535	Imputed	C	ADDITIVE	0.06224	0.577	0.7882	0.8017	0.0001	89.23
  rs3015535	Imputed	C	DOMINANT	0.06057	0.5529	0.7739	0.7744	0.0001	89.62
  rs3019407	Imputed	A	GENOTYPIC	0.002403	0.1245	0.5457	0.5319	0.0182	75.03
  rs3019407	Imputed	A	RECESSIVE	0.001969	0.0794	0.5543	0.5343	0.0367	69.74
  rs36071725	Genotyped	C	GENOTYPIC	0.0009841	0.1525	1.8209	1.6916	0.0188	74.82
  rs373983	Imputed	G	DOMINANT	1.77E−06	4.87E−05	1.7251	1.7129	0.2675	24.16
  rs3756154	Imputed	C	DOMINANT	5.58E−05	5.58E−05	0.638	0.638	0.5323	0
  rs3793044	Imputed	C	ADDITIVE	0.0002176	0.02467	1.7666	1.7835	0.0668	63.04
  rs3793044	Imputed	C	DOMINANT	6.05E−05	0.01168	1.9281	1.9369	0.0827	59.88
  rs3793053	Imputed	C	ADDITIVE	0.0006473	0.05829	1.6129	1.6372	0.0373	69.61
  rs3793053	Imputed	C	DOMINANT	0.0001802	0.05295	1.7738	1.7934	0.0253	72.81
  rs3796246	Imputed	G	ADDITIVE	4.93E−05	0.03123	0.5626	0.5598	0.033	70.67
  rs3796246	Imputed	G	DOMINANT	7.61E−05	0.03997	0.5604	0.5582	0.0279	72.06
  rs3805996	Imputed	G	ADDITIVE	0.0004631	0.03555	1.7203	1.7316	0.0645	63.52
  rs3805996	Imputed	G	DOMINANT	0.0001039	0.01905	1.8935	1.8966	0.069	62.59
  rs3806003	Imputed	A	ADDITIVE	0.0002176	0.02467	1.7666	1.7835	0.0668	63.04
  rs3806003	Imputed	A	DOMINANT	6.05E−05	0.01168	1.9281	1.9369	0.0827	59.88
  rs3806004	Imputed	T	ADDITIVE	0.0004046	0.06127	1.629	1.6716	0.0232	73.43
  rs3806004	Imputed	T	DOMINANT	8.69E−05	0.05774	1.806	1.8451	0.013	76.96
  rs3806010	Imputed	T	ADDITIVE	0.0005021	0.06161	1.6166	1.6531	0.0272	72.27
  rs3806010	Imputed	T	DOMINANT	0.0001126	0.05784	1.7901	1.8228	0.0156	75.95
  rs3806014	Imputed	T	ADDITIVE	0.0003765	0.04916	1.6371	1.6672	0.0355	70.04
  rs3806014	Imputed	T	DOMINANT	8.67E−05	0.04874	1.8125	1.8369	0.0201	74.42
  rs3806015	Imputed	A	ADDITIVE	0.0004101	0.05336	1.6326	1.6624	0.0328	70.72
  rs3806015	Imputed	A	DOMINANT	9.18E−05	0.05129	1.8094	1.8329	0.019	74.77
  rs3806018	Imputed	A	ADDITIVE	0.0005021	0.06161	1.6166	1.6531	0.0272	72.27
  rs3806018	Imputed	A	DOMINANT	0.0001126	0.05784	1.7901	1.8228	0.0156	75.95
  rs3806019	Imputed	A	ADDITIVE	0.0003369	0.06994	1.6486	1.6857	0.017	75.46
  rs3806019	Imputed	A	DOMINANT	7.78E−05	0.06342	1.8244	1.854	0.0108	77.94
  rs3806024	Imputed	T	ADDITIVE	0.0005633	0.04683	1.6102	1.6476	0.0429	68.25
  rs3806024	Imputed	T	DOMINANT	0.0001927	0.05215	1.7603	1.7924	0.0243	73.09
  rs3847825	Imputed	G	ADDITIVE	2.82E−05	2.82E−05	0.7256	0.7256	0.8316	0
  rs3847825	Imputed	G	GENOTYPIC	1.92E−05	1.92E−05	0.492	0.492	0.6711	0
  rs3852001	Genotyped	C	GENOTYPIC	0.0001464	0.003339	2.8436	2.7528	0.2138	35.18
  rs3852001	Genotyped	C	RECESSIVE	0.0002312	0.004125	2.7294	2.6501	0.2177	34.41
  rs3852002	Imputed	G	GENOTYPIC	0.0001829	0.002345	2.8057	2.7354	0.2427	29.38
  rs3852002	Imputed	G	RECESSIVE	0.0003087	0.003378	2.6791	2.6162	0.2416	29.6
  rs3852003	Imputed	A	GENOTYPIC	0.0001804	0.002239	2.8085	2.7392	0.2448	28.95
  rs3852003	Imputed	A	RECESSIVE	0.0003059	0.003283	2.6808	2.6185	0.243	29.31
  rs3942254	Imputed	T	DOMINANT	1.57E−05	1.57E−05	0.6155	0.6155	0.9263	0
  rs3945085	Imputed	A	DOMINANT	4.70E−05	4.70E−05	1.5394	1.5394	0.4131	0
  rs399485	Imputed	A	DOMINANT	6.74E−05	6.74E−05	1.5257	1.5257	0.824	0
  rs4029119	Imputed	G	ADDITIVE	0.009526	0.1165	0.5497	0.3516	0.0037	82.15
  rs4029119	Imputed	G	DOMINANT	0.01808	0.1591	0.5432	0.3678	0.0036	82.19
  rs412791	Imputed	C	GENOTYPIC	0.001957	0.1114	0.5748	0.6018	0.0485	66.96
  rs4146972	Genotyped	T	DOMINANT	5.77E−05	5.77E−05	1.5876	1.5876	0.6206	0
  rs4259369	Imputed	C	RECESSIVE	8.16E−05	8.16E−05	0.5849	0.5849	0.3771	0
  rs4273613	Imputed	T	ADDITIVE	0.008222	0.1202	0.5498	0.3996	0.0061	80.4
  rs4273613	Imputed	T	DOMINANT	0.01557	0.1677	0.5436	0.4204	0.006	80.44
  rs4294022	Imputed	C	DOMINANT	0.001643	0.075	0.7108	0.7149	0.0535	65.84
  rs4310554	Genotyped	C	DOMINANT	8.90E−05	8.90E−05	1.6571	1.6571	0.9259	0
  rs4315598	Imputed	T	ADDITIVE	3.44E−05	3.44E−05	1.3737	1.3737	0.9473	0
  rs4315598	Imputed	T	GENOTYPIC	2.26E−05	2.26E−05	2.0022	2.0022	0.9124	0
  rs4370878	Imputed	G	DOMINANT	7.67E−05	7.67E−05	1.5204	1.5204	0.455	0
  rs4436200	Imputed	C	ADDITIVE	9.10E−05	9.10E−05	0.6326	0.6326	0.5686	0
  rs4444612	Imputed	G	ADDITIVE	3.11E−05	3.11E−05	1.376	1.376	0.9378	0
  rs4444612	Imputed	G	GENOTYPIC	2.11E−05	2.11E−05	2.0071	2.0071	0.9192	0
  rs4450660	Imputed	C	DOMINANT	4.65E−05	4.65E−05	1.546	1.546	0.4995	0
  rs4463950	Imputed	C	DOMINANT	0.0001125	0.0001125	0.6464	0.6464	0.456	0
  rs4509702	Imputed	C	DOMINANT	7.67E−05	7.67E−05	1.5204	1.5204	0.455	0
  rs4533379	Imputed	G	ADDITIVE	0.0001806	0.006299	1.3772	1.3597	0.1875	40.27
  rs4569984	Imputed	A	DOMINANT	0.001158	0.06124	0.7017	0.7047	0.0591	64.65
  rs4570530	Imputed	C	DOMINANT	6.91E−05	6.91E−05	1.5246	1.5246	0.4388	0
  rs4571583	Imputed	T	DOMINANT	0.001089	0.04319	0.7015	0.7036	0.0837	59.69
  rs4586678	Imputed	A	DOMINANT	7.84E−05	7.84E−05	1.5241	1.5241	0.4333	0
  rs4615971	Imputed	C	DOMINANT	5.32E−05	5.32E−05	1.5364	1.5364	0.4014	0
  rs4629229	Imputed	G	DOMINANT	0.00258	0.1967	0.7027	0.7323	0.0172	75.39
  rs4632512	Imputed	T	GENOTYPIC	0.0002417	0.001846	2.7571	2.7036	0.2673	24.2
  rs4641552	Imputed	A	ADDITIVE	6.42E−05	6.42E−05	0.5503	0.5503	0.8687	0
  rs4682527	Imputed	C	DOMINANT	6.46E−05	6.46E−05	1.7014	1.7014	0.8635	0
  rs4688632	Imputed	G	RECESSIVE	9.44E−05	9.44E−05	0.6102	0.6102	0.6914	0
  rs4702720	Imputed	A	ADDITIVE	6.79E−05	6.79E−05	0.6668	0.6668	0.5886	0
  rs4702720	Imputed	A	DOMINANT	5.81E−05	5.81E−05	0.6111	0.6111	0.6679	0
  rs4714484	Imputed	A	ADDITIVE	0.0001156	0.0001156	0.6714	0.6714	0.4129	0
  rs4714484	Imputed	A	DOMINANT	0.0001018	0.0005019	0.6342	0.6347	0.2947	18.15
  rs4725142	Genotyped	G	RECESSIVE	0.006009	0.1578	0.6241	0.5998	0.0142	76.48
  rs4725144	Imputed	G	RECESSIVE	0.003615	0.1263	0.601	0.5821	0.0196	74.58
  rs4760785	Imputed	A	ADDITIVE	2.89E−05	2.89E−05	0.7236	0.7236	0.9224	0
  rs4760785	Imputed	A	DOMINANT	3.37E−05	3.37E−05	0.6199	0.6199	0.7756	0
  rs4760894	Imputed	T	ADDITIVE	2.89E−05	2.89E−05	0.7236	0.7236	0.9224	0
  rs4760894	Imputed	T	DOMINANT	3.37E−05	3.37E−05	0.6199	0.6199	0.7756	0
  rs4760895	Imputed	A	ADDITIVE	2.89E−05	2.89E−05	0.7236	0.7236	0.9224	0
  rs4760895	Imputed	A	DOMINANT	3.37E−05	3.37E−05	0.6199	0.6199	0.7756	0
  rs4767184	Imputed	C	ADDITIVE	5.36E−05	5.36E−05	0.7326	0.7326	0.8638	0
  rs4767184	Imputed	C	GENOTYPIC	4.89E−05	4.89E−05	0.5118	0.5118	0.7734	0
  rs4773487	Imputed	T	ADDITIVE	0.06464	0.5842	0.7937	0.8107	0.0001	88.81
  rs4780547	Imputed	G	GENOTYPIC	5.45E−05	5.45E−05	0.3432	0.3432	0.6588	0
  rs4780547	Imputed	G	RECESSIVE	5.24E−05	5.24E−05	0.3485	0.3485	0.7035	0
  rs483159	Imputed	T	DOMINANT	1.80E−05	9.87E−05	1.6374	1.6337	0.3052	15.73
  rs4836502	Imputed	T	DOMINANT	4.20E−07	4.20E−07	0.5804	0.5804	0.9556	0
  rs4836507	Imputed	C	DOMINANT	3.81E−07	3.81E−07	0.5776	0.5776	0.9618	0
  rs4851531	Imputed	T	DOMINANT	6.05E−05	6.05E−05	0.6433	0.6433	0.6076	0
  rs4879931	Imputed	G	ADDITIVE	4.07E−05	4.07E−05	0.7128	0.7128	0.8034	0
  rs489441	Imputed	G	ADDITIVE	5.61E−05	5.61E−05	1.4311	1.4311	0.5197	0
  rs489441	Imputed	G	DOMINANT	2.23E−05	2.23E−05	1.5959	1.5959	0.6258	0
  rs4976276	Imputed	T	ADDITIVE	0.001258	0.05097	1.303	1.2929	0.0811	60.2
  rs4977681	Imputed	C	RECESSIVE	0.00128	0.05237	1.78	1.7408	0.0817	60.08
  rs4986197	Imputed	G	ADDITIVE	0.0001721	0.0051	1.3789	1.3622	0.1995	37.96
  rs4986220	Imputed	T	ADDITIVE	0.0002571	0.00494	1.3704	1.3563	0.2157	34.81
  rs525462	Imputed	A	GENOTYPIC	8.63E−05	8.63E−05	0.5509	0.5509	0.4841	0
  rs552006	Imputed	G	GENOTYPIC	0.001362	0.0951	1.9014	1.8396	0.056	65.31
  rs5756669	Imputed	C	DOMINANT	0.0005154	0.01565	1.5032	1.4817	0.1536	46.63
  rs581905	Imputed	T	DOMINANT	9.62E−05	9.62E−05	1.7493	1.7493	0.4492	0
  rs6033138	Imputed	C	ADDITIVE	3.11E−05	3.11E−05	1.376	1.376	0.9378	0
  rs6033138	Imputed	C	GENOTYPIC	2.11E−05	2.11E−05	2.0071	2.0071	0.9192	0
  rs6040619	Imputed	C	ADDITIVE	1.85E−05	1.85E−05	1.3887	1.3887	0.9157	0
  rs6040619	Imputed	C	GENOTYPIC	1.34E−05	1.34E−05	2.0393	2.0393	0.8907	0
  rs6040625	Imputed	T	ADDITIVE	1.40E−05	1.40E−05	1.3939	1.3939	0.9254	0
  rs6040625	Imputed	T	GENOTYPIC	1.13E−05	1.13E−05	2.049	2.049	0.9295	0
  rs6040630	Imputed	A	ADDITIVE	1.64E−05	1.64E−05	1.3913	1.3913	0.9442	0
  rs6040630	Imputed	A	GENOTYPIC	1.40E−05	1.40E−05	2.0387	2.0387	0.936	0
  rs6040633	Imputed	A	ADDITIVE	2.09E−05	2.09E−05	1.3848	1.3848	0.9611	0
  rs6040633	Imputed	A	GENOTYPIC	1.80E−05	1.80E−05	2.0179	2.0179	0.921	0
  rs6040634	Imputed	T	ADDITIVE	4.42E−05	4.42E−05	1.3644	1.3644	0.8661	0
  rs6040634	Imputed	T	GENOTYPIC	4.35E−05	4.35E−05	1.9421	1.9421	0.8577	0
  rs6040636	Imputed	T	ADDITIVE	5.80E−05	5.80E−05	1.3581	1.3581	0.8982	0
  rs6040636	Imputed	T	GENOTYPIC	5.08E−05	5.08E−05	1.9311	1.9311	0.8975	0
  rs6040638	Imputed	C	ADDITIVE	3.11E−05	3.11E−05	1.376	1.376	0.9378	0
  rs6040638	Imputed	C	GENOTYPIC	2.11E−05	2.11E−05	2.0071	2.0071	0.9192	0
  rs6040644	Imputed	A	ADDITIVE	3.11E−05	3.11E−05	1.376	1.376	0.9378	0
  rs6040644	Imputed	A	GENOTYPIC	2.11E−05	2.11E−05	2.0071	2.0071	0.9192	0
  rs6040667	Imputed	T	ADDITIVE	9.98E−06	9.98E−06	1.4087	1.4087	0.9927	0
  rs6040667	Imputed	T	GENOTYPIC	9.55E−06	9.55E−06	2.0887	2.0887	0.8885	0
  rs6040668	Imputed	C	ADDITIVE	1.34E−05	1.34E−05	1.4018	1.4018	0.9954	0
  rs6040668	Imputed	C	GENOTYPIC	1.18E−05	1.18E−05	2.0792	2.0792	0.9007	0
  rs6053005	Imputed	C	DOMINANT	3.48E−05	3.48E−05	0.4986	0.4986	0.3762	0
  rs6054405	Imputed	A	RECESSIVE	0.0009988	0.07764	1.6353	1.5918	0.0508	66.45
  rs6054427	Genotyped	G	GENOTYPIC	0.002955	0.1457	1.6159	1.564	0.0304	71.38
  rs6075186	Imputed	G	DOMINANT	0.00258	0.1967	0.7027	0.7323	0.0172	75.39
  rs608278	Imputed	A	ADDITIVE	0.004256	0.2162	0.7899	0.8041	0.0123	77.26
  rs6111540	Imputed	A	ADDITIVE	0.0006805	0.04588	0.7626	0.7772	0.0894	58.58
  rs6131206	Imputed	C	ADDITIVE	6.54E−05	6.54E−05	1.3826	1.3826	0.6671	0
  rs6131208	Imputed	T	ADDITIVE	1.51E−05	1.51E−05	1.3987	1.3987	0.9933	0
  rs6131208	Imputed	T	GENOTYPIC	1.23E−05	1.23E−05	2.0749	2.0749	0.9062	0
  rs6131919	Imputed	G	DOMINANT	0.00258	0.1967	0.7027	0.7323	0.0172	75.39
  rs6134243	Imputed	C	ADDITIVE	3.11E−05	3.11E−05	1.376	1.376	0.9378	0
  rs6134243	Imputed	C	GENOTYPIC	2.11E−05	2.11E−05	2.0071	2.0071	0.9192	0
  rs6136020	Imputed	A	DOMINANT	0.001123	0.128	0.6825	0.7095	0.029	71.76
  rs613799	Imputed	C	DOMINANT	6.64E−05	6.64E−05	1.5582	1.5582	0.563	0
  rs644041	Imputed	G	ADDITIVE	5.13E−05	5.13E−05	1.4383	1.4383	0.434	0
  rs644041	Imputed	G	DOMINANT	3.43E−05	3.43E−05	1.5867	1.5867	0.604	0
  rs6464377	Imputed	C	DOMINANT	0.0006889	0.03533	1.6713	1.6228	0.1067	55.32
  rs6474230	Imputed	T	DOMINANT	5.89E−05	5.89E−05	1.5358	1.5358	0.5248	0
  rs6476565	Imputed	A	DOMINANT	0.003196	0.152	0.6555	0.6646	0.0232	73.43
  rs6511286	Imputed	T	ADDITIVE	0.0002903	0.007727	1.3303	1.3382	0.1549	46.38
  rs6541829	Genotyped	C	RECESSIVE	9.75E−05	9.75E−05	2.1906	2.1906	0.675	0
  rs6544721	Imputed	G	DOMINANT	6.03E−05	6.03E−05	1.5337	1.5337	0.3986	0
  rs6544728	Imputed	T	DOMINANT	2.14E−05	2.14E−05	1.5769	1.5769	0.5608	0
  rs6565910	Imputed	G	DOMINANT	0.001296	0.07989	0.7061	0.72	0.0544	65.66
  rs6581985	Imputed	G	GENOTYPIC	2.27E−05	2.27E−05	2.3281	2.3281	0.8	0
  rs6581985	Imputed	G	RECESSIVE	1.65E−05	1.65E−05	2.2816	2.2816	0.9608	0
  rs6685186	Imputed	T	ADDITIVE	0.0003893	0.03193	1.3177	1.2933	0.1024	56.12
  rs6685186	Imputed	T	GENOTYPIC	0.0003148	0.008032	1.8077	1.753	0.2038	37.13
  rs670593	Imputed	A	RECESSIVE	9.20E−05	9.20E−05	0.5443	0.5443	0.5165	0
  rs6722640	Imputed	T	DOMINANT	3.75E−05	3.75E−05	0.6354	0.6354	0.7462	0
  rs6746170	Imputed	A	DOMINANT	1.59E−05	1.59E−05	1.5871	1.5871	0.5677	0
  rs6757316	Imputed	A	GENOTYPIC	7.94E−05	7.94E−05	1.8639	1.8639	0.8329	0
  rs6805139	Imputed	G	DOMINANT	6.87E−05	6.87E−05	1.6408	1.6408	0.6877	0
  rs6808571	Imputed	G	ADDITIVE	0.0001557	0.005296	1.488	1.4637	0.1931	39.2
  rs6816479	Imputed	A	RECESSIVE	0.003461	0.1734	1.5638	1.5108	0.0221	73.76
  rs6865976	Imputed	C	DOMINANT	0.000638	0.09658	0.6509	0.6693	0.03	71.48
  rs687047	Imputed	C	ADDITIVE	8.99E−05	8.99E−05	0.6274	0.6274	0.7784	0
  rs6871041	Imputed	G	DOMINANT	1.95E−06	1.95E−06	0.5936	0.5936	0.8021	0
  rs688358	Imputed	A	ADDITIVE	9.13E−05	9.13E−05	0.6275	0.6275	0.8668	0
  rs6908481	Imputed	C	RECESSIVE	2.63E−05	2.63E−05	1.8066	1.8066	0.4929	0
  rs6917224	Imputed	A	ADDITIVE	0.001611	0.08952	1.2619	1.2426	0.0537	65.81
  rs6917224	Imputed	A	GENOTYPIC	0.0004783	0.01846	1.6983	1.6636	0.1376	49.58
  rs6920677	Imputed	G	DOMINANT	0.0006978	0.02695	0.6902	0.689	0.1022	56.16
  rs6994498	Imputed	G	DOMINANT	6.45E−05	6.45E−05	1.5326	1.5326	0.525	0
  rs6998772	Imputed	T	DOMINANT	0.0001667	0.007582	2.0855	2.0402	0.1794	41.79
  rs7022281	Imputed	C	ADDITIVE	3.37E−05	3.37E−05	0.7208	0.7208	0.9446	0
  rs7022281	Imputed	C	GENOTYPIC	1.15E−05	1.15E−05	0.4698	0.4698	0.7053	0
  rs7022281	Imputed	C	RECESSIVE	5.13E−05	5.13E−05	0.5256	0.5256	0.4654	0
  rs7043983	Imputed	T	DOMINANT	0.002465	0.1237	0.6468	0.6573	0.0334	70.58
  rs7077799	Imputed	A	DOMINANT	6.50E−05	6.50E−05	1.5274	1.5274	0.444	0
  rs7088947	Imputed	A	ADDITIVE	6.35E−05	6.35E−05	0.5164	0.5164	0.4696	0
  rs7089661	Imputed	C	DOMINANT	5.72E−05	5.72E−05	1.532	1.532	0.4194	0
  rs7102072	Imputed	A	DOMINANT	0.0002045	0.02025	0.6732	0.6851	0.1048	55.66
  rs710832	Genotyped	A	RECESSIVE	9.58E−05	9.58E−05	0.3757	0.3757	0.7653	0
  rs712531	Imputed	A	DOMINANT	3.11E−05	3.11E−05	1.7258	1.7258	0.9033	0
  rs7129817	Imputed	T	ADDITIVE	0.0004049	0.005979	0.7557	0.7602	0.2144	35.05
  rs7134262	Imputed	T	GENOTYPIC	3.73E−05	3.73E−05	2.0446	2.0446	0.769	0
  rs7134262	Imputed	T	RECESSIVE	1.57E−06	1.57E−06	2.1811	2.1811	0.5132	0
  rs7138300	Imputed	C	ADDITIVE	2.89E−05	2.89E−05	0.7236	0.7236	0.9224	0
  rs7138300	Imputed	C	DOMINANT	3.37E−05	3.37E−05	0.6199	0.6199	0.7756	0
  rs722927	Imputed	G	ADDITIVE	0.0002059	0.003095	0.5581	0.5621	0.2265	32.66
  rs722927	Imputed	G	DOMINANT	0.0002882	0.006064	0.554	0.5592	0.1936	39.11
  rs726424	Genotyped	G	ADDITIVE	6.99E−05	6.99E−05	0.7384	0.7384	0.8568	0
  rs726424	Genotyped	G	GENOTYPIC	4.04E−05	4.04E−05	0.5084	0.5084	0.769	0
  rs7295817	Imputed	C	ADDITIVE	3.56E−06	3.56E−06	0.701	0.701	0.8251	0
  rs7295817	Imputed	C	GENOTYPIC	2.94E−06	2.94E−06	0.4697	0.4697	0.6858	0
  rs7295817	Imputed	C	RECESSIVE	3.56E−05	3.56E−05	0.5434	0.5434	0.4419	0
  rs7297372	Imputed	A	ADDITIVE	2.15E−05	2.15E−05	0.7143	0.7143	0.9056	0
  rs7297372	Imputed	A	GENOTYPIC	2.33E−05	2.33E−05	0.5078	0.5078	0.9111	0
  rs7298255	Imputed	A	ADDITIVE	5.48E−05	5.48E−05	0.7363	0.7363	0.9823	0
  rs7298255	Imputed	A	DOMINANT	3.71E−05	3.71E−05	0.6235	0.6235	0.616	0
  rs7305832	Imputed	C	GENOTYPIC	3.46E−05	3.46E−05	2.0496	2.0496	0.7658	0
  rs7305832	Imputed	C	RECESSIVE	1.42E−06	1.42E−06	2.1877	2.1877	0.5185	0
  rs737542	Imputed	A	RECESSIVE	6.40E−05	6.40E−05	2.2711	2.2711	0.5666	0
  rs742827	Imputed	A	ADDITIVE	1.36E−05	1.36E−05	1.4066	1.4066	0.9977	0
  rs742827	Imputed	A	GENOTYPIC	1.47E−05	1.47E−05	2.0678	2.0678	0.9063	0
  rs7446891	Imputed	G	DOMINANT	4.14E−07	4.14E−07	0.5792	0.5792	0.9644	0
  rs7448641	Imputed	C	ADDITIVE	0.008373	0.1243	0.5451	0.3771	0.0037	82.12
  rs7448641	Imputed	C	DOMINANT	0.0151	0.1693	0.5356	0.3959	0.0036	82.2
  rs7460605	Imputed	G	DOMINANT	9.83E−05	9.83E−05	1.5669	1.5669	0.9301	0
  rs7468898	Imputed	T	ADDITIVE	0.0003194	0.01248	1.3212	1.3172	0.1401	49.12
  rs7468898	Imputed	T	GENOTYPIC	0.0002964	0.008259	1.7563	1.7465	0.1684	43.86
  rs7501186	Imputed	A	DOMINANT	9.69E−05	9.69E−05	1.6046	1.6046	0.3847	0
  rs755117	Imputed	A	DOMINANT	0.01024	0.3598	1.3434	1.288	0.0039	81.94
  rs7557560	Imputed	T	GENOTYPIC	0.0001246	0.01108	2.8561	3.1286	0.074	61.59
  rs7557560	Imputed	T	RECESSIVE	6.13E−05	0.00416	2.9547	3.1843	0.1154	53.69
  rs7562462	Imputed	T	DOMINANT	0.01544	0.4455	1.3282	1.2791	0.0007	86.22
  rs757173	Genotyped	G	DOMINANT	0.0006476	0.08534	0.6914	0.7167	0.0461	67.51
  rs7607447	Imputed	T	RECESSIVE	9.84E−05	9.84E−05	2.0418	2.0418	0.8641	0
  rs7639053	Imputed	A	ADDITIVE	0.00063	0.02671	1.3617	1.3527	0.1105	54.61
  rs7648163	Imputed	C	RECESSIVE	0.001045	0.07747	1.7344	1.7565	0.0313	71.14
  rs7651273	Imputed	A	GENOTYPIC	0.0003041	0.01221	2.7407	2.6004	0.1624	44.99
  rs7653190	Imputed	C	ADDITIVE	0.0008578	0.04731	1.3535	1.3419	0.0766	61.08
  rs7653685	Genotyped	C	DOMINANT	0.003653	0.1786	1.4802	1.4969	0.0084	79.08
  rs7684899	Imputed	C	DOMINANT	9.54E−05	9.54E−05	0.6466	0.6466	0.5013	0
  rs7701604	Imputed	G	ADDITIVE	0.008373	0.1243	0.5451	0.3771	0.0037	82.12
  rs7701604	Imputed	G	DOMINANT	0.0151	0.1693	0.5356	0.3959	0.0036	82.2
  rs7703676	Imputed	C	ADDITIVE	0.008373	0.1243	0.5451	0.3771	0.0037	82.12
  rs7703676	Imputed	C	DOMINANT	0.0151	0.1693	0.5356	0.3959	0.0036	82.2
  rs7711358	Imputed	A	DOMINANT	6.11E−07	6.11E−07	0.5846	0.5846	0.9519	0
  rs7713251	Imputed	C	RECESSIVE	0.0004673	0.01381	1.817	1.8103	0.1436	48.48
  rs7737608	Imputed	G	DOMINANT	0.004374	0.3589	1.3752	1.2994	0.0019	83.98
  rs7755903	Imputed	A	GENOTYPIC	0.000545	0.01934	0.5737	0.5711	0.1208	52.69
  rs7762993	Imputed	A	ADDITIVE	0.0001907	0.02185	1.4428	1.3966	0.1265	51.63
  rs7762993	Imputed	A	DOMINANT	5.98E−05	0.0279	1.5641	1.5155	0.0621	64.02
  rs7767265	Imputed	G	DOMINANT	1.02E−05	0.01409	1.6165	1.5706	0.0624	63.96
  rs7769415	Imputed	C	GENOTYPIC	8.18E−05	8.18E−05	2.0029	2.0029	0.4259	0
  rs7771264	Imputed	T	DOMINANT	0.001814	0.07578	0.7128	0.7164	0.055	65.53
  rs7795792	Imputed	T	RECESSIVE	8.16E−05	8.16E−05	0.5849	0.5849	0.3771	0
  rs7806481	Imputed	G	RECESSIVE	0.01058	0.4116	0.7116	0.7366	0.0005	86.94
  rs7808536	Imputed	G	DOMINANT	8.83E−05	8.83E−05	1.5445	1.5445	0.4545	0
  rs7814819	Imputed	G	ADDITIVE	1.73E−05	1.73E−05	2.1934	2.1934	0.7688	0
  rs7814819	Imputed	G	DOMINANT	5.48E−06	5.48E−06	2.3941	2.3941	0.8199	0
  rs7815952	Imputed	T	DOMINANT	0.0001667	0.007582	2.0855	2.0402	0.1794	41.79
  rs7834090	Imputed	T	DOMINANT	0.0001667	0.007582	2.0855	2.0402	0.1794	41.79
  rs7859250	Imputed	C	DOMINANT	0.002865	0.1511	0.6526	0.6624	0.0221	73.76
  rs7863577	Genotyped	A	ADDITIVE	0.001489	0.09537	0.6564	0.6635	0.037	69.66
  rs7863577	Genotyped	A	DOMINANT	0.0007401	0.03086	0.6143	0.6263	0.1159	53.59
  rs7902140	Imputed	C	ADDITIVE	0.0004487	0.01039	0.7037	0.7112	0.1881	40.15
  rs7921834	Imputed	C	DOMINANT	5.72E−05	5.72E−05	1.5321	1.5321	0.4195	0
  rs7939893	Imputed	C	ADDITIVE	6.01E−05	6.01E−05	0.7308	0.7308	0.6443	0
  rs7939893	Imputed	C	DOMINANT	2.83E−06	2.83E−06	0.607	0.607	0.54	0
  rs7955901	Imputed	C	ADDITIVE	4.86E−05	4.86E−05	0.7344	0.7344	0.959	0
  rs7955901	Imputed	C	DOMINANT	2.65E−05	2.65E−05	0.617	0.617	0.71	0
  rs7956274	Imputed	T	ADDITIVE	5.90E−05	5.90E−05	0.7346	0.7346	0.9732	0
  rs7956274	Imputed	T	DOMINANT	3.36E−05	3.36E−05	0.6194	0.6194	0.7678	0
  rs7957932	Imputed	G	ADDITIVE	7.64E−05	7.64E−05	0.7393	0.7393	0.9682	0
  rs7957932	Imputed	G	DOMINANT	1.49E−05	1.49E−05	0.604	0.604	0.7593	0
  rs7984294	Imputed	A	DOMINANT	9.75E−05	9.75E−05	1.7346	1.7346	0.5063	0
  rs7994286	Imputed	A	ADDITIVE	0.07908	0.6072	0.8008	0.8163	0.0001	89.29
  rs7994286	Imputed	A	DOMINANT	0.08583	0.5854	0.7921	0.7921	0.0001	89.54
  rs8038229	Genotyped	A	ADDITIVE	6.08E−05	9.60E−05	0.7204	0.7188	0.3455	5.89
  rs8038229	Genotyped	A	DOMINANT	9.63E−05	9.63E−05	0.6627	0.6627	0.4576	0
  rs8043336	Imputed	C	GENOTYPIC	0.00137	0.05581	0.5451	0.5279	0.0522	66.13
  rs8043336	Imputed	C	RECESSIVE	0.001089	0.03846	0.5559	0.5432	0.0772	60.96
  rs8054431	Imputed	T	DOMINANT	8.98E−05	0.00368	1.557	1.5551	0.1739	42.83
  rs8066502	Imputed	T	DOMINANT	8.43E−05	8.43E−05	0.6277	0.6277	0.5424	0
  rs8068714	Imputed	T	DOMINANT	8.71E−05	8.71E−05	0.6283	0.6283	0.5356	0
  rs892575	Imputed	T	ADDITIVE	0.0003596	0.01472	1.3576	1.3374	0.1542	46.51
  rs892583	Imputed	G	ADDITIVE	0.0002367	0.004322	1.3734	1.3595	0.2211	33.74
  rs915494	Imputed	A	ADDITIVE	5.04E−05	5.04E−05	1.401	1.401	0.4759	0
  rs915494	Imputed	A	DOMINANT	1.99E−05	7.05E−05	1.5873	1.5804	0.3261	10.76
  rs917295	Imputed	G	DOMINANT	4.33E−07	4.33E−07	0.5808	0.5808	0.9574	0
  rs922594	Imputed	T	DOMINANT	5.29E−05	5.29E−05	0.6483	0.6483	0.5564	0
  rs9301653	Imputed	T	ADDITIVE	0.06224	0.577	0.7882	0.8017	0.0001	89.23
  rs9301653	Imputed	T	DOMINANT	0.06057	0.5529	0.7739	0.7744	0.0001	89.62
  rs9309988	Imputed	G	DOMINANT	0.003653	0.1786	1.4802	1.4969	0.0084	79.08
  rs9309989	Genotyped	C	DOMINANT	0.005145	0.2346	1.4559	1.4701	0.0036	82.24
  rs9310221	Imputed	A	DOMINANT	0.0004892	0.152	1.5136	1.4374	0.0126	77.16
  rs9327555	Imputed	T	DOMINANT	4.20E−07	4.20E−07	0.5804	0.5804	0.9556	0
  rs937890	Imputed	G	DOMINANT	6.84E−05	6.84E−05	0.6201	0.6201	0.5639	0
  rs9454967	Imputed	G	ADDITIVE	0.000403	0.06626	1.6379	1.6775	0.0204	74.32
  rs9454967	Imputed	G	DOMINANT	9.90E−05	0.06125	1.8091	1.8433	0.0126	77.13
  rs9471295	Imputed	T	DOMINANT	5.22E−05	5.22E−05	1.6081	1.6081	0.834	0
  rs9477007	Imputed	A	ADDITIVE	0.0006021	0.03371	1.2928	1.2761	0.1007	56.44
  rs9477007	Imputed	A	GENOTYPIC	0.0002564	0.005808	1.7495	1.7219	0.1967	38.49
  rs9487279	Imputed	T	DOMINANT	0.002105	0.09969	0.7072	0.7196	0.0492	66.8
  rs949016	Imputed	C	ADDITIVE	0.0002405	0.007834	1.372	1.3542	0.1841	40.91
  rs9555973	Imputed	G	ADDITIVE	0.07024	0.5911	0.7954	0.8108	0.0001	89
  rs9555973	Imputed	G	DOMINANT	0.07631	0.5694	0.7863	0.7867	0.0001	89.22
  rs9557510	Imputed	G	ADDITIVE	5.36E−05	5.36E−05	1.5231	1.5231	0.7181	0
  rs9557510	Imputed	G	DOMINANT	4.27E−05	4.27E−05	1.6282	1.6282	0.5332	0
  rs9560584	Imputed	T	DOMINANT	0.0887	0.5829	0.792	0.7896	0.0001	89.53
  rs9588770	Imputed	T	DOMINANT	0.07854	0.5309	0.7885	0.772	0.0001	88.8
  rs9588848	Imputed	C	ADDITIVE	0.06224	0.577	0.7882	0.8017	0.0001	89.23
  rs9588848	Imputed	C	DOMINANT	0.06057	0.5529	0.7739	0.7744	0.0001	89.62
  rs966583	Imputed	A	ADDITIVE	9.26E−05	9.26E−05	0.7367	0.7367	0.9674	0
  rs966583	Imputed	A	DOMINANT	1.20E−05	1.20E−05	0.6161	0.6161	0.8284	0
  rs974130	Genotyped	A	RECESSIVE	0.002277	0.101	1.5851	1.5579	0.0437	68.05
  rs977160	Imputed	T	ADDITIVE	0.0002651	0.05569	1.3742	1.3339	0.0564	65.23
  rs9812206	Imputed	G	ADDITIVE	5.56E−05	0.05202	0.5663	0.5775	0.0221	73.76
  rs9812206	Imputed	G	DOMINANT	8.50E−05	0.05567	0.5652	0.5728	0.021	74.13
  rs9813552	Imputed	G	ADDITIVE	9.05E−05	0.0567	0.5743	0.5799	0.0208	74.16
  rs9813552	Imputed	G	DOMINANT	0.0001441	0.07188	0.5733	0.5795	0.0165	75.64
  rs9815037	Imputed	T	ADDITIVE	7.92E−05	0.0586	0.5721	0.5786	0.0188	74.84
  rs9815037	Imputed	T	DOMINANT	0.0001241	0.07373	0.5708	0.5779	0.0148	76.27
  rs9825349	Imputed	A	ADDITIVE	7.92E−05	0.0586	0.5721	0.5786	0.0188	74.84
  rs9825349	Imputed	A	DOMINANT	0.0001241	0.07373	0.5708	0.5779	0.0148	76.27
  rs9834217	Imputed	T	ADDITIVE	6.37E−05	0.04695	0.5683	0.5735	0.024	73.19
  rs9834217	Imputed	T	DOMINANT	9.99E−05	0.05997	0.5668	0.5725	0.0192	74.7
  rs9840460	Imputed	T	ADDITIVE	6.24E−05	0.0469	0.5679	0.5732	0.0239	73.23
  rs9840460	Imputed	T	DOMINANT	9.77E−05	0.05992	0.5664	0.5721	0.0191	74.75
  rs9840756	Imputed	A	ADDITIVE	5.29E−05	0.04056	0.5646	0.5694	0.0275	72.18
  rs9840756	Imputed	A	DOMINANT	8.32E−05	0.05269	0.563	0.5684	0.022	73.8
  rs9844801	Imputed	C	DOMINANT	0.003653	0.1786	1.4802	1.4969	0.0084	79.08
  rs985375	Imputed	A	GENOTYPIC	0.0005024	0.0184	2.1795	2.1225	0.1411	48.93
  rs9869187	Imputed	C	ADDITIVE	0.0002129	0.05227	0.587	0.5974	0.0378	69.48
  rs9869187	Imputed	C	DOMINANT	0.0005049	0.05719	0.5988	0.6038	0.0436	68.07
  rs9872327	Imputed	T	DOMINANT	0.003653	0.1786	1.4802	1.4969	0.0084	79.08
  rs9881685	Imputed	A	ADDITIVE	5.96E−05	0.0538	0.5653	0.5735	0.0205	74.27
  rs9881685	Imputed	A	DOMINANT	8.36E−05	0.0568	0.5632	0.5683	0.0192	74.71
  rs9909499	Imputed	C	DOMINANT	6.59E−05	6.59E−05	1.5349	1.5349	0.7556	0
  rs9911847	Imputed	G	DOMINANT	6.59E−05	6.59E−05	0.6229	0.6229	0.5677	0
  rs9946886	Imputed	G	RECESSIVE	5.84E−05	5.84E−05	0.3084	0.3084	0.8937	0
  rs9958823	Imputed	A	ADDITIVE	0.0001257	0.005478	1.3904	1.3724	0.1829	41.13
  rs9965248	Imputed	T	ADDITIVE	0.0006176	0.03664	1.3453	1.3168	0.1086	54.95

• TABLE 14
  		ALLELE
  SNP rs #	SOURCE	(A1)	MODEL	NMISS	OR	SE	L95	U95	STAT	P
  rs77638540	Genotyped	T	DOM	800	0.3686	0.3223	0.196	0.6931	−3.097	0.001952
  rs72746987	Genotyped	A	DOM	800	0.3351	0.3134	0.1813	0.6195	−3.488	0.000487
  rs10021016	Genotyped	G	GEN	800					7.997	0.01834
  rs10021016	Genotyped	G	REC	800	2.242	0.2913	1.266	3.967	2.771	0.005589
  rs10051148	Imputed	C	DOM	796	0.6544	0.1465	0.491	0.8722	−2.893	0.003813
  rs10054055	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs10067895	Imputed	A	DOM	791	0.6716	0.1473	0.5032	0.8964	−2.703	0.006874
  rs10100725	Imputed	C	DOM	800	0.5483	0.1594	0.4011	0.7494	−3.769	0.000164
  rs10128531	Imputed	T	ADD	742	1.482	0.1557	1.092	2.011	2.526	0.01154
  rs10181743	Imputed	G	ADD	762	1.488	0.1083	1.204	1.84	3.673	0.00024
  rs10199127	Imputed	T	DOM	780	1.486	0.1462	1.116	1.98	2.712	0.006692
  rs10270624	Imputed	G	DOM	750	1.438	0.1529	1.066	1.94	2.375	0.01754
  rs1030006	Imputed	G	REC	797	1.663	0.1726	1.186	2.333	2.947	0.003209
  rs1031811	Imputed	A	REC	792	1.684	0.2618	1.008	2.813	1.991	0.04646
  rs10430870	Genotyped	G	GEN	800					8.659	0.01317
  rs10430870	Genotyped	G	REC	800	2.178	0.2884	1.237	3.833	2.698	0.006973
  rs10469597	Imputed	A	GEN	739					11.61	0.003011
  rs10469597	Imputed	A	REC	739	2.519	0.2716	1.479	4.289	3.401	0.00067
  rs10478919	Imputed	G	DOM	797	0.6489	0.1462	0.4872	0.8644	−2.957	0.003109
  rs10506623	Imputed	C	ADD	777	0.7349	0.1071	0.5957	0.9066	−2.875	0.004041
  rs10506623	Imputed	C	DOM	777	0.6128	0.1531	0.454	0.8273	−3.199	0.001381
  rs10506626	Imputed	A	ADD	795	0.7463	0.105	0.6075	0.9169	−2.786	0.005339
  rs10506626	Imputed	A	DOM	795	0.5922	0.1495	0.4418	0.7938	−3.504	0.000458
  rs10509477	Imputed	T	DOM	800	1.654	0.1456	1.243	2.2	3.456	0.000547
  rs10517918	Imputed	G	REC	798	1.697	0.1851	1.181	2.439	2.858	0.004265
  rs10517924	Imputed	A	REC	800	1.803	0.1754	1.279	2.543	3.362	0.000773
  rs10519362	Imputed	G	DOM	784	1.5	0.1539	1.109	2.028	2.634	0.00844
  rs10520072	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs10737390	Imputed	T	DOM	787	0.5772	0.1513	0.4291	0.7764	−3.632	0.000281
  rs10742851	Imputed	T	REC	800	0.406	0.2924	0.2289	0.7202	−3.083	0.002051
  rs10743685	Imputed	G	GEN	795					12.35	0.002076
  rs10743685	Imputed	G	REC	795	1.943	0.1919	1.334	2.831	3.462	0.000536
  rs10749293	Imputed	G	DOM	797	1.637	0.1456	1.231	2.178	3.387	0.000706
  rs10749294	Imputed	A	DOM	798	1.575	0.1455	1.184	2.095	3.123	0.00179
  rs10753760	Imputed	T	ADD	745	1.391	0.1067	1.128	1.715	3.093	0.001984
  rs10753760	Imputed	T	GEN	745					9.763	0.007586
  rs10772362	Imputed	T	ADD	800	0.6338	0.1259	0.4952	0.8112	−3.621	0.000293
  rs10784891	Imputed	C	ADD	765	0.7164	0.1084	0.5792	0.886	−3.077	0.002092
  rs10784891	Imputed	C	DOM	765	0.631	0.1608	0.4604	0.8648	−2.863	0.004193
  rs10784891	Imputed	C	GEN	765					9.725	0.007731
  rs10787923	Imputed	G	DOM	796	1.647	0.1457	1.238	2.191	3.425	0.000616
  rs10787924	Imputed	T	DOM	797	1.585	0.1456	1.191	2.109	3.163	0.001564
  rs10787949	Imputed	A	DOM	800	1.634	0.1456	1.228	2.173	3.373	0.000745
  rs10787951	Imputed	G	DOM	800	1.634	0.1456	1.228	2.173	3.373	0.000745
  rs10787983	Imputed	C	DOM	798	1.614	0.1449	1.215	2.144	3.304	0.000953
  rs10794733	Imputed	C	ADD	786	0.765	0.1126	0.6135	0.9539	−2.379	0.01734
  rs10818280	Imputed	C	DOM	788	0.7042	0.1448	0.5302	0.9353	−2.422	0.01544
  rs10860586	Imputed	A	ADD	796	1.322	0.1036	1.079	1.62	2.695	0.007028
  rs10860586	Imputed	A	GEN	796					7.298	0.02602
  rs10870473	Imputed	A	ADD	371	0.54	0.1831	0.3772	0.773	−3.366	0.000762
  rs10870473	Imputed	A	DOM	371	0.4734	0.2198	0.3077	0.7283	−3.402	0.000668
  rs10879240	Imputed	C	ADD	791	0.7324	0.1067	0.5942	0.9027	−2.92	0.003505
  rs10879240	Imputed	C	GEN	791					8.522	0.0141
  rs10879242	Imputed	A	ADD	793	0.741	0.1058	0.6022	0.9117	−2.834	0.0046
  rs10879242	Imputed	A	DOM	793	0.6085	0.1511	0.4525	0.8182	−3.288	0.00101
  rs10879245	Imputed	G	ADD	793	0.741	0.1058	0.6022	0.9117	−2.834	0.0046
  rs10879245	Imputed	G	DOM	793	0.6085	0.1511	0.4525	0.8182	−3.288	0.00101
  rs10879249	Imputed	T	ADD	795	0.7264	0.1064	0.5897	0.8947	−3.006	0.00265
  rs10879249	Imputed	T	DOM	795	0.6001	0.151	0.4464	0.8068	−3.382	0.00072
  rs10886429	Imputed	A	DOM	797	1.634	0.1459	1.228	2.175	3.365	0.000766
  rs10886449	Imputed	G	DOM	800	1.594	0.145	1.2	2.119	3.217	0.001297
  rs10886451	Imputed	G	DOM	800	1.594	0.145	1.2	2.119	3.217	0.001297
  rs10886452	Imputed	A	DOM	800	1.634	0.1456	1.228	2.173	3.373	0.000745
  rs10886456	Imputed	G	DOM	800	1.594	0.145	1.2	2.119	3.217	0.001297
  rs10886463	Imputed	C	DOM	800	1.624	0.1458	1.221	2.162	3.327	0.000878
  rs10886465	Imputed	A	DOM	800	1.664	0.1454	1.251	2.212	3.503	0.000461
  rs10886526	Imputed	C	DOM	798	1.614	0.1449	1.215	2.144	3.304	0.000953
  rs10922903	Imputed	C	REC	800	0.4885	0.1995	0.3304	0.7222	−3.591	0.000329
  rs10941126	Imputed	G	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs10941126	Imputed	G	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs10947980	Imputed	G	ADD	798	0.7397	0.1176	0.5875	0.9314	−2.564	0.01033
  rs11059376	Imputed	T	ADD	720	1.559	0.1386	1.188	2.045	3.203	0.001362
  rs11072995	Imputed	T	GEN	793					9.167	0.01022
  rs11072995	Imputed	T	REC	793	3.578	0.4502	1.481	8.646	2.832	0.004626
  rs11081202	Genotyped	G	GEN	800					7.034	0.02969
  rs11081202	Genotyped	G	REC	800	1.887	0.2769	1.097	3.248	2.294	0.0218
  rs110965	Imputed	C	GEN	737					5.271	0.07169
  rs11124962	Imputed	A	DOM	790	1.469	0.1461	1.103	1.956	2.63	0.008532
  rs1116596	Imputed	T	DOM	794	0.6531	0.1466	0.49	0.8704	−2.907	0.003646
  rs11178531	Imputed	A	ADD	796	0.7599	0.1049	0.6187	0.9334	−2.618	0.008858
  rs11178531	Imputed	A	DOM	796	0.6258	0.1604	0.4569	0.857	−2.922	0.003477
  rs11178583	Imputed	A	ADD	796	0.7274	0.1063	0.5906	0.896	−2.993	0.002762
  rs11178583	Imputed	A	DOM	796	0.6032	0.1509	0.4488	0.8108	−3.35	0.000809
  rs11178589	Imputed	T	ADD	787	0.7243	0.1059	0.5885	0.8915	−3.044	0.002334
  rs11178589	Imputed	T	DOM	787	0.5988	0.1526	0.444	0.8075	−3.362	0.000775
  rs11178594	Imputed	C	ADD	797	0.7305	0.1059	0.5936	0.8991	−2.964	0.003033
  rs11178594	Imputed	C	DOM	797	0.5995	0.1509	0.446	0.8058	−3.391	0.000696
  rs11178602	Imputed	T	ADD	795	0.7265	0.1059	0.5904	0.8941	−3.018	0.002545
  rs11178602	Imputed	T	DOM	795	0.592	0.1508	0.4405	0.7956	−3.476	0.00051
  rs11178648	Imputed	T	ADD	794	0.7481	0.1053	0.6086	0.9195	−2.757	0.00584
  rs11178648	Imputed	T	DOM	794	0.5905	0.1497	0.4403	0.7918	−3.52	0.000432
  rs11198877	Imputed	T	DOM	800	1.634	0.1456	1.228	2.173	3.373	0.000745
  rs11198942	Imputed	T	DOM	800	1.654	0.1456	1.243	2.2	3.456	0.000547
  rs11221075	Imputed	A	ADD	725	0.6446	0.1613	0.4698	0.8842	−2.723	0.006476
  rs11242020	Imputed	T	DOM	798	0.6462	0.1462	0.4852	0.8606	−2.987	0.002819
  rs11242021	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs11242022	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs11242023	Imputed	T	DOM	795	0.6676	0.1469	0.5005	0.8904	−2.75	0.00596
  rs1149349	Imputed	T	DOM	798	1.696	0.1575	1.245	2.309	3.352	0.000802
  rs1149350	Imputed	A	ADD	789	1.592	0.131	1.232	2.058	3.552	0.000383
  rs1149350	Imputed	A	DOM	789	1.701	0.1501	1.267	2.282	3.539	0.000401
  rs11576627	Imputed	T	ADD	800	1.72	0.1612	1.254	2.358	3.364	0.000769
  rs11576627	Imputed	T	DOM	800	1.805	0.1683	1.298	2.51	3.508	0.000451
  rs11630050	Imputed	G	GEN	778					8.696	0.01294
  rs11630050	Imputed	G	REC	778	3.097	0.3961	1.425	6.731	2.854	0.004317
  rs11633024	Imputed	C	GEN	778					8.696	0.01294
  rs11633024	Imputed	C	REC	778	3.097	0.3961	1.425	6.731	2.854	0.004317
  rs11636298	Imputed	G	GEN	800					9.499	0.008657
  rs11636298	Imputed	G	REC	800	3.433	0.4298	1.478	7.972	2.87	0.004111
  rs11637363	Imputed	C	GEN	774					9.788	0.007493
  rs11637363	Imputed	C	REC	774	3.309	0.3942	1.528	7.166	3.035	0.002402
  rs11637813	Imputed	A	GEN	778					8.696	0.01294
  rs11637813	Imputed	A	REC	778	3.097	0.3961	1.425	6.731	2.854	0.004317
  rs11638043	Imputed	C	GEN	777					8.808	0.01223
  rs11638043	Imputed	C	REC	777	2.984	0.3815	1.413	6.303	2.866	0.00416
  rs11638115	Imputed	A	GEN	793					9.167	0.01022
  rs11638115	Imputed	A	REC	793	3.578	0.4502	1.481	8.646	2.832	0.004626
  rs11638444	Imputed	C	GEN	799					9.274	0.009687
  rs11717157	Imputed	T	ADD	800	1.366	0.1079	1.105	1.688	2.889	0.00386
  rs11717157	Imputed	T	GEN	800					9.972	0.006832
  rs11724055	Imputed	A	DOM	798	0.6341	0.1569	0.4662	0.8624	−2.903	0.003694
  rs11743355	Imputed	C	ADD	732	0.2056	0.4133	0.0915	0.4623	−3.827	0.00013
  rs11743355	Imputed	C	DOM	732	0.2102	0.4294	0.0906	0.4878	−3.632	0.000282
  rs11746806	Imputed	T	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs11746806	Imputed	T	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs11746959	Imputed	T	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs11746959	Imputed	T	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs11749272	Imputed	T	DOM	797	0.6489	0.1462	0.4872	0.8644	−2.957	0.003109
  rs11839636	Imputed	C	GEN	789					12.4	0.002029
  rs11839785	Imputed	C	GEN	782					12.37	0.002065
  rs11853619	Imputed	C	GEN	799					9.423	0.008993
  rs11853619	Imputed	C	REC	799	3.396	0.4296	1.463	7.882	2.846	0.004433
  rs11856780	Imputed	A	GEN	799					9.423	0.008993
  rs11856780	Imputed	A	REC	799	3.396	0.4296	1.463	7.882	2.846	0.004433
  rs11901899	Imputed	A	DOM	767	1.388	0.1476	1.039	1.853	2.22	0.02644
  rs11903290	Imputed	C	REC	793	1.68	0.2618	1.006	2.807	1.982	0.04748
  rs11909480	Imputed	G	ADD	797	0.3557	0.3375	0.1836	0.6892	−3.063	0.00219
  rs11909480	Imputed	G	DOM	797	0.3552	0.3405	0.1822	0.6924	−3.04	0.002368
  rs11910289	Imputed	T	ADD	765	1.705	0.2347	1.077	2.702	2.274	0.02295
  rs11910289	Imputed	T	DOM	765	1.77	0.2428	1.1	2.848	2.351	0.01871
  rs11920375	Genotyped	C	GEN	800					10.36	0.005635
  rs11926319	Imputed	G	DOM	799	0.5553	0.1951	0.3788	0.8139	−3.015	0.002567
  rs11933744	Imputed	T	REC	799	2.427	0.2805	1.401	4.206	3.162	0.001567
  rs11934919	Imputed	C	REC	799	2.427	0.2805	1.401	4.206	3.162	0.001567
  rs11934957	Imputed	C	REC	799	2.427	0.2805	1.401	4.206	3.162	0.001567
  rs11959206	Imputed	A	REC	795	0.528	0.177	0.3733	0.7469	−3.609	0.000307
  rs12038613	Imputed	C	REC	783	0.4896	0.2003	0.3306	0.7249	−3.566	0.000363
  rs12151417	Imputed	T	DOM	763	1.463	0.1495	1.091	1.961	2.545	0.01093
  rs12153185	Imputed	T	DOM	792	0.6694	0.1472	0.5016	0.8933	−2.726	0.006403
  rs12182651	Imputed	T	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs12235345	Imputed	C	DOM	793	2.195	0.2213	1.423	3.387	3.553	0.000382
  rs12324786	Imputed	T	GEN	793					9.167	0.01022
  rs12324786	Imputed	T	REC	793	3.578	0.4502	1.481	8.646	2.832	0.004626
  rs12336958	Imputed	G	DOM	738	1.777	0.159	1.301	2.427	3.617	0.000298
  rs12407412	Imputed	C	ADD	800	1.72	0.1612	1.254	2.358	3.364	0.000769
  rs12407412	Imputed	C	DOM	800	1.805	0.1683	1.298	2.51	3.508	0.000451
  rs12418971	Imputed	C	GEN	765					9.69	0.007866
  rs12418971	Imputed	C	REC	765	2.279	0.2931	1.283	4.048	2.811	0.004945
  rs1241967	Imputed	T	REC	798	0.3933	0.2549	0.2387	0.6482	−3.661	0.000252
  rs12420184	Imputed	G	DOM	796	0.5503	0.165	0.3982	0.7604	−3.619	0.000295
  rs12433968	Imputed	T	DOM	762	0.5602	0.1482	0.419	0.749	−3.91	9.23E−05
  rs12445477	Imputed	A	DOM	771	0.5609	0.2128	0.3696	0.8512	−2.717	0.006591
  rs12447191	Genotyped	T	ADD	800	0.6857	0.1355	0.5258	0.8943	−2.785	0.005354
  rs12447191	Genotyped	T	DOM	800	0.7141	0.1537	0.5284	0.9651	−2.191	0.02846
  rs12465349	Imputed	A	REC	781	1.474	0.166	1.065	2.041	2.338	0.01938
  rs1247340	Imputed	C	ADD	798	1.541	0.1317	1.191	1.995	3.286	0.001016
  rs1247340	Imputed	C	DOM	798	1.679	0.1496	1.252	2.251	3.461	0.000538
  rs1247341	Imputed	C	ADD	797	1.534	0.1317	1.185	1.986	3.248	0.001161
  rs1247341	Imputed	C	DOM	797	1.668	0.1498	1.244	2.237	3.416	0.000635
  rs1247343	Imputed	C	DOM	787	1.673	0.158	1.228	2.281	3.258	0.001121
  rs12509758	Imputed	C	DOM	799	1.449	0.1495	1.081	1.942	2.48	0.01313
  rs12515472	Imputed	A	DOM	799	1.337	0.1509	0.9948	1.798	1.925	0.0542
  rs12548906	Imputed	G	ADD	761	1.308	0.1403	0.9936	1.722	1.914	0.05563
  rs12596240	Imputed	G	DOM	800	0.5814	0.1491	0.434	0.7787	−3.637	0.000275
  rs12618781	Imputed	A	DOM	792	0.6189	0.1597	0.4526	0.8463	−3.005	0.002655
  rs12678600	Imputed	A	DOM	800	0.6105	0.1458	0.4588	0.8125	−3.384	0.000715
  rs12692229	Imputed	T	ADD	795	1.248	0.1075	1.011	1.541	2.063	0.03912
  rs12713324	Imputed	T	DOM	779	1.464	0.1484	1.094	1.958	2.566	0.01029
  rs12719415	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	4.86E−03
  rs12820589	Imputed	G	ADD	757	1.483	0.1384	1.13	1.945	2.846	0.004422
  rs12820589	Imputed	G	DOM	757	1.498	0.1543	1.107	2.028	2.621	0.008774
  rs12831292	Imputed	G	ADD	788	0.73	0.1065	0.5925	0.8994	−2.955	0.003122
  rs12831292	Imputed	G	DOM	788	0.5953	0.1521	0.4418	0.802	−3.411	0.000647
  rs13012636	Imputed	G	REC	794	1.692	0.2617	1.013	2.827	2.01	0.04442
  rs13038146	Imputed	C	ADD	800	1.353	0.1061	1.099	1.666	2.854	0.004317
  rs13038146	Imputed	C	GEN	800					9.956	0.006888
  rs13038146	Imputed	C	REC	800	1.892	0.2107	1.252	2.859	3.026	0.002474
  rs13089860	Imputed	A	DOM	653	0.647	0.1731	0.4609	0.9083	−2.516	0.01188
  rs13102419	Imputed	T	REC	779	1.798	0.1756	1.274	2.536	3.339	0.000841
  rs13194907	Imputed	A	ADD	800	1.998	0.2096	1.325	3.013	3.302	0.00096
  rs13194907	Imputed	A	DOM	800	2.076	0.2229	1.341	3.213	3.276	1.05E−03
  rs13195745	Imputed	A	ADD	799	1.993	0.2097	1.322	3.006	3.29	0.001001
  rs13195745	Imputed	A	DOM	799	2.07	0.223	1.337	3.204	3.263	0.001101
  rs13265054	Imputed	T	DOM	798	0.6161	0.146	0.4628	0.8202	−3.318	0.000908
  rs13273002	Imputed	A	GEN	798					12.57	0.001864
  rs13282131	Imputed	C	ADD	797	1.33	0.1054	1.081	1.635	2.702	0.006897
  rs13282131	Imputed	C	GEN	797					7.883	0.01942
  rs13282131	Imputed	C	REC	797	1.605	0.1832	1.121	2.299	2.583	0.009794
  rs1330052	Imputed	G	GEN	800					15.12	0.00052
  rs1335721	Imputed	A	REC	783	0.4896	0.2003	0.3306	0.7249	−3.566	0.000363
  rs1336382	Imputed	T	DOM	795	1.652	0.146	1.241	2.2	3.438	0.000587
  rs1336383	Imputed	T	DOM	800	1.654	0.1456	1.243	2.2	3.456	0.000547
  rs1336407	Imputed	T	DOM	800	1.62	0.1448	1.22	2.152	3.335	0.000854
  rs1336409	Imputed	T	DOM	800	1.62	0.1448	1.22	2.152	3.335	0.000854
  rs1336596	Imputed	A	DOM	796	0.5452	0.1487	0.4073	0.7298	−4.078	4.54E−05
  rs13387284	Imputed	A	DOM	760	0.6185	0.1611	0.451	0.8482	−2.982	0.002863
  rs13401462	Imputed	C	DOM	760	1.748	0.1697	1.254	2.438	3.292	0.000996
  rs13409045	Imputed	T	ADD	792	0.7208	0.1088	0.5824	0.8921	−3.01	0.002612
  rs1349284	Imputed	C	GEN	800					9.296	0.009578
  rs1355715	Imputed	T	ADD	800	0.4791	0.2123	0.316	0.7263	−3.467	0.000527
  rs1357696	Imputed	A	GEN	782					10.92	0.004251
  rs1357698	Imputed	A	GEN	781					11.09	0.003915
  rs1357699	Imputed	T	GEN	781					11.09	0.003915
  rs1363273	Imputed	C	REC	780	0.5424	0.1801	0.3811	0.772	−3.397	0.000682
  rs1373601	Imputed	A	DOM	731	0.6665	0.1502	0.4966	0.8946	−2.702	0.006895
  rs1375829	Imputed	C	GEN	800					9.296	0.009578
  rs1395748	Imputed	G	DOM	800	0.6151	0.1445	0.4634	0.8164	−3.364	0.000769
  rs1414865	Imputed	T	DOM	800	1.634	0.1456	1.228	2.173	3.373	0.000745
  rs1414873	Imputed	A	DOM	800	1.62	0.1448	1.22	2.152	3.335	0.000854
  rs1414876	Imputed	C	DOM	800	1.62	0.1448	1.22	2.152	3.335	0.000854
  rs1424643	Imputed	G	ADD	778	1.348	0.1253	1.054	1.723	2.38	0.0173
  rs1424643	Imputed	G	DOM	778	1.485	0.149	1.109	1.988	2.654	0.007946
  rs1424648	Imputed	T	DOM	784	1.357	0.1474	1.017	1.812	2.073	0.03819
  rs1429321	Imputed	A	DOM	797	1.456	0.1473	1.091	1.943	2.549	0.01079
  rs1429326	Imputed	T	ADD	792	1.336	0.1238	1.048	1.702	2.338	0.01941
  rs1429326	Imputed	T	DOM	792	1.48	0.1477	1.108	1.977	2.653	0.007971
  rs1444741	Imputed	A	DOM	728	0.6595	0.1504	0.4911	0.8857	−2.767	0.005653
  rs1449916	Imputed	C	DOM	588	0.5892	0.1909	0.4052	0.8566	−2.771	0.005596
  rs1459523	Imputed	A	ADD	800	1.366	0.1079	1.105	1.688	2.889	0.00386
  rs1459523	Imputed	A	GEN	800					9.972	0.006832
  rs1466352	Imputed	T	GEN	797					9.958	0.00688
  rs1466353	Imputed	G	GEN	796					10.02	0.006658
  rs1476714	Imputed	A	DOM	797	0.6618	0.1469	0.4962	0.8826	−2.81	0.004957
  rs1486723	Imputed	C	REC	800	0.4458	0.2394	0.2789	0.7127	−3.375	0.000739
  rs1495375	Imputed	A	ADD	793	0.741	0.1058	0.6022	0.9117	−2.834	0.0046
  rs1495375	Imputed	A	DOM	793	0.6085	0.1511	0.4525	0.8182	−3.288	0.00101
  rs1495381	Imputed	T	GEN	799					8.222	0.01639
  rs1495381	Imputed	T	REC	799	1.776	0.2004	1.199	2.631	2.867	0.004141
  rs1498061	Imputed	C	ADD	385	0.4939	0.2066	0.3294	0.7405	−3.414	0.00064
  rs1498992	Imputed	G	DOM	795	0.5981	0.1449	0.4502	0.7944	−3.549	0.000387
  rs1499001	Imputed	T	DOM	763	0.5667	0.1498	0.4225	0.76	−3.793	0.000149
  rs1512988	Imputed	A	ADD	795	0.7274	0.1066	0.5903	0.8964	−2.987	0.002819
  rs1512988	Imputed	A	DOM	795	0.6077	0.151	0.452	0.817	−3.298	0.000973
  rs1512989	Imputed	T	ADD	795	0.7274	0.1066	0.5903	0.8964	−2.987	0.002819
  rs1512989	Imputed	T	DOM	795	0.6077	0.151	0.452	0.817	−3.298	0.000973
  rs1512991	Imputed	T	ADD	795	0.7286	0.1054	0.5926	0.8957	−3.005	0.002655
  rs1512991	Imputed	T	DOM	795	0.6184	0.1596	0.4523	0.8456	−3.011	0.002605
  rs1512991	Imputed	T	GEN	795					9.858	0.007235
  rs1524303	Imputed	T	GEN	793					9.356	0.009296
  rs1524306	Imputed	C	ADD	800	1.366	0.1079	1.105	1.688	2.889	0.00386
  rs1524306	Imputed	C	GEN	800					9.972	0.006832
  rs1524310	Imputed	G	ADD	800	1.366	0.1079	1.105	1.688	2.889	0.00386
  rs1524310	Imputed	G	GEN	800					9.972	0.006832
  rs1524321	Imputed	C	GEN	796					10.02	0.006673
  rs1527059	Imputed	A	DOM	799	0.5689	0.2041	0.3813	0.8488	−2.763	0.005727
  rs152707	Imputed	A	ADD	800	0.684	0.1058	0.5559	0.8415	−3.592	0.000328
  rs152707	Imputed	A	GEN	800					13.34	0.001266
  rs152712	Genotyped	C	ADD	799	0.6783	0.106	0.5511	0.8349	−3.663	0.00025
  rs152712	Genotyped	C	GEN	799					14.09	0.00087
  rs1533994	Imputed	T	GEN	799					10.31	0.005765
  rs1535866	Imputed	G	DOM	793	1.391	0.148	1.041	1.86	2.232	0.02564
  rs1563773	Imputed	T	GEN	798					10.17	0.006179
  rs1563774	Imputed	T	GEN	794					9.994	0.006759
  rs1567740	Imputed	T	ADD	796	0.7274	0.1063	0.5906	0.896	−2.993	0.002762
  rs1567740	Imputed	T	DOM	796	0.6032	0.1509	0.4488	0.8108	−3.35	0.000809
  rs1572573	Imputed	A	DOM	770	1.748	0.1541	1.292	2.365	3.624	0.00029
  rs1577497	Imputed	C	REC	786	0.4912	0.2002	0.3317	0.7272	−3.551	0.000384
  rs1581514	Imputed	T	ADD	795	1.353	0.108	1.095	1.671	2.797	0.005152
  rs1581514	Imputed	T	GEN	795					9.607	0.008202
  rs1582321	Imputed	T	DOM	800	0.5814	0.1491	0.434	0.7787	−3.637	0.000275
  rs1582322	Imputed	A	DOM	799	0.5859	0.1493	0.4373	0.785	−3.581	0.000342
  rs1582323	Imputed	A	DOM	798	0.5825	0.1494	0.4346	0.7807	−3.617	0.000298
  rs1592485	Imputed	C	DOM	799	0.5835	0.15	0.4349	0.7829	−3.592	0.000328
  rs1600954	Imputed	T	ADD	759	1.379	0.106	1.12	1.697	3.029	0.002457
  rs1600954	Imputed	T	GEN	759					11.97	0.002519
  rs16938626	Imputed	G	DOM	797	0.612	0.1451	0.4605	0.8132	−3.385	0.000711
  rs16964300	Imputed	G	ADD	800	0.6771	0.135	0.5197	0.8821	−2.889	0.003862
  rs16964300	Imputed	G	DOM	800	0.7073	0.1536	0.5234	0.9558	−2.254	0.02418
  rs16986282	Imputed	G	DOM	800	0.3124	0.3551	0.1558	0.6267	−3.276	0.001053
  rs17007620	Imputed	G	ADD	696	1.421	0.1303	1.101	1.834	2.696	0.007027
  rs17007620	Imputed	G	DOM	696	1.572	0.1588	1.152	2.146	2.85	0.004376
  rs17014326	Imputed	G	DOM	794	0.5837	0.145	0.4393	0.7755	−3.713	0.000205
  rs17047957	Imputed	C	DOM	785	1.47	0.1535	1.088	1.986	2.51	0.01207
  rs1705261	Imputed	A	REC	798	1.775	0.1989	1.202	2.622	2.885	0.003908
  rs17073341	Imputed	A	ADD	800	2.568	0.2635	1.532	4.305	3.58	0.000344
  rs17073341	Imputed	A	DOM	800	2.569	0.2659	1.525	4.326	3.548	0.000388
  rs17138702	Imputed	G	ADD	797	0.5527	0.1573	0.406	0.7522	−3.77	0.000163
  rs17189710	Imputed	T	ADD	795	1.359	0.1063	1.103	1.673	2.882	0.003957
  rs17189710	Imputed	T	GEN	795					10.06	0.006549
  rs17189710	Imputed	T	REC	795	1.896	0.2108	1.254	2.866	3.034	0.002411
  rs17310176	Imputed	T	ADD	800	0.6381	0.1364	0.4884	0.8336	−3.294	0.000988
  rs17310176	Imputed	T	DOM	800	0.5794	0.1584	0.4248	0.7903	−3.446	0.00057
  rs17358860	Imputed	A	DOM	800	0.6291	0.1568	0.4626	0.8555	−2.955	0.003129
  rs17370541	Imputed	T	GEN	752					13.88	0.000967
  rs17370541	Imputed	T	REC	752	2.075	0.2103	1.374	3.133	3.469	0.000522
  rs17526574	Imputed	G	GEN	800					11.97	0.002516
  rs17530747	Imputed	T	DOM	797	0.5794	0.1476	0.4338	0.7738	−3.698	0.000218
  rs17649114	Imputed	C	DOM	800	1.543	0.1498	1.151	2.07	2.898	0.00376
  rs17766172	Imputed	A	REC	770	0.3869	0.2703	0.2278	0.6573	−3.512	0.000444
  rs1818885	Imputed	G	GEN	794					10.03	0.006649
  rs1832222	Imputed	G	DOM	799	1.612	0.1449	1.214	2.142	3.295	0.000984
  rs1861327	Imputed	G	DOM	800	0.5814	0.1491	0.434	0.7787	−3.637	0.000275
  rs1868581	Imputed	G	ADD	800	1.366	0.1079	1.105	1.688	2.889	0.00386
  rs1868581	Imputed	G	GEN	800					9.972	0.006832
  rs1874313	Imputed	A	ADD	797	0.7419	0.1059	0.6029	0.913	−2.819	0.004818
  rs1874313	Imputed	A	DOM	797	0.615	0.1508	0.4577	0.8265	−3.224	0.001263
  rs1876409	Imputed	C	DOM	800	0.6151	0.1445	0.4634	0.8164	−3.364	0.000769
  rs1913201	Imputed	G	ADD	771	0.7218	0.1078	0.5844	0.8916	−3.025	0.002485
  rs1913201	Imputed	G	DOM	771	0.6464	0.1598	0.4726	0.8841	−2.731	0.006318
  rs1913201	Imputed	G	GEN	771					9.268	0.009717
  rs1916922	Imputed	T	GEN	800					9.972	0.006832
  rs1936871	Genotyped	G	DOM	800	0.571	0.1536	0.4226	0.7716	−3.647	0.000265
  rs1961157	Imputed	T	REC	800	0.6068	0.1891	0.4189	0.8791	−2.642	0.00825
  rs1987179	Imputed	T	ADD	800	0.7138	0.1326	0.5504	0.9257	−2.542	0.01103
  rs1987179	Imputed	T	DOM	800	0.6634	0.1489	0.4955	0.8883	−2.756	0.005859
  rs1990023	Imputed	T	DOM	798	0.6462	0.1462	0.4852	0.8606	−2.987	0.002819
  rs1995025	Imputed	C	DOM	775	1.608	0.1638	1.167	2.217	2.901	0.003714
  rs2016194	Imputed	G	DOM	799	0.6626	0.1466	0.4971	0.8832	−2.807	0.004996
  rs2023651	Imputed	T	ADD	797	0.682	0.1247	0.5341	0.8707	−3.07	0.002139
  rs2024902	Imputed	A	ADD	800	1.998	0.2096	1.325	3.013	3.302	0.00096
  rs2024902	Imputed	A	DOM	800	2.076	0.2229	1.341	3.213	3.276	0.001053
  rs2025107	Imputed	A	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs2025108	Imputed	T	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs2031987	Imputed	T	GEN	795					12.3	0.002134
  rs2052428	Imputed	C	DOM	784	0.5903	0.1642	0.4279	0.8144	−3.21	0.001327
  rs2053230	Imputed	C	ADD	722	0.5414	0.1548	0.3998	0.7333	−3.964	7.36E−05
  rs2062448	Imputed	T	DOM	788	0.5462	0.1963	0.3718	0.8024	−3.081	0.00206
  rs2063420	Imputed	C	REC	780	1.755	0.1868	1.217	2.531	3.01	0.002608
  rs2063591	Imputed	C	ADD	797	0.7519	0.1046	0.6125	0.9229	−2.727	0.006392
  rs2063591	Imputed	C	DOM	797	0.6237	0.1609	0.4551	0.855	−2.934	0.003349
  rs208026	Genotyped	A	DOM	800	1.457	0.1466	1.093	1.941	2.565	0.01032
  rs208029	Imputed	T	DOM	786	1.41	0.1496	1.052	1.891	2.298	0.02157
  rs208757	Imputed	G	DOM	799	1.423	0.1463	1.068	1.895	2.411	0.01592
  rs2095586	Imputed	A	DOM	785	1.655	0.1465	1.242	2.205	3.438	0.000586
  rs2095606	Imputed	A	DOM	786	0.5466	0.1493	0.4079	0.7324	−4.046	5.20E−05
  rs2102374	Imputed	A	ADD	790	0.6269	0.1219	0.4937	0.7961	−3.831	0.000128
  rs2102374	Imputed	A	DOM	790	0.5989	0.1465	0.4494	0.798	−3.501	0.000464
  rs2108426	Imputed	C	DOM	799	0.6626	0.1466	0.4971	0.8832	−2.807	0.004996
  rs2110664	Imputed	A	DOM	744	1.429	0.1493	1.066	1.915	2.391	0.01682
  rs2132242	Imputed	A	ADD	793	0.7317	0.1056	0.5948	0.9	−2.957	0.003104
  rs2132242	Imputed	A	DOM	793	0.6043	0.1522	0.4484	0.8143	−3.309	0.000936
  rs2158958	Imputed	A	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs2158961	Imputed	G	DOM	796	0.6544	0.1465	0.491	0.8722	−2.893	0.003813
  rs2163046	Imputed	A	DOM	775	1.474	0.149	1.101	1.973	2.603	0.009245
  rs2180286	Imputed	G	DOM	798	0.6211	0.164	0.4503	0.8566	−2.903	0.003694
  rs2180684	Imputed	A	DOM	800	1.684	0.1876	1.166	2.433	2.779	0.005451
  rs2188079	Imputed	C	ADD	798	1.333	0.1034	1.088	1.632	2.775	0.005514
  rs2188079	Imputed	C	GEN	798					10.2	0.006111
  rs2190598	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs2190600	Imputed	A	DOM	791	0.6716	0.1473	0.5032	0.8964	−2.703	0.006874
  rs2224184	Genotyped	T	DOM	800	0.6357	0.1621	0.4626	0.8735	−2.794	0.005199
  rs2247066	Imputed	A	DOM	800	0.6151	0.1445	0.4634	0.8164	−3.364	0.000769
  rs2248236	Imputed	C	ADD	728	0.6377	0.1466	0.4784	0.85	−3.068	0.002153
  rs2248236	Imputed	C	DOM	728	0.6049	0.1624	0.44	0.8317	−3.095	0.00197
  rs2265733	Imputed	C	ADD	790	0.6269	0.1219	0.4937	0.7961	−3.831	0.000128
  rs2265733	Imputed	C	DOM	790	0.5989	0.1465	0.4494	0.798	−3.501	0.000464
  rs2270584	Imputed	A	ADD	796	0.7437	0.1051	0.6052	0.9138	−2.818	0.004834
  rs2270584	Imputed	A	DOM	796	0.5859	0.1496	0.437	0.7855	−3.574	0.000351
  rs2270586	Imputed	A	ADD	795	0.7444	0.1051	0.6059	0.9147	−2.808	0.004978
  rs2270586	Imputed	A	DOM	795	0.5879	0.1496	0.4385	0.7883	−3.55	0.000385
  rs229775	Imputed	A	REC	798	0.3933	0.2549	0.2387	0.6482	−3.661	0.000252
  rs229815	Imputed	T	REC	762	0.4053	0.2727	0.2375	0.6916	−3.312	0.000925
  rs229829	Imputed	C	REC	797	0.5066	0.2182	0.3303	0.7769	−3.117	0.001827
  rs229831	Imputed	A	REC	797	0.3945	0.2549	0.2394	0.6501	−3.65	0.000263
  rs2317057	Imputed	T	ADD	623	0.7125	0.1358	0.546	0.9298	−2.496	0.01256
  rs2322100	Genotyped	T	REC	800	1.768	0.28	1.021	3.061	2.035	0.04187
  rs2322101	Imputed	A	REC	799	1.764	0.28	1.019	3.053	2.026	0.04276
  rs2327929	Imputed	G	REC	799	1.996	0.1838	1.392	2.862	3.761	0.000169
  rs2332844	Imputed	A	ADD	681	1.802	0.1484	1.347	2.41	3.969	7.22E−05
  rs2332844	Imputed	A	REC	681	1.849	0.1698	1.326	2.579	3.62	0.000295
  rs2349170	Imputed	G	DOM	797	1.638	0.1487	1.224	2.192	3.319	0.000903
  rs2356722	Imputed	G	DOM	798	0.5863	0.1447	0.4416	0.7785	−3.691	0.000223
  rs2364956	Imputed	T	ADD	772	1.439	0.1382	1.098	1.887	2.634	0.008429
  rs2373793	Imputed	G	ADD	792	1.379	0.1411	1.046	1.818	2.279	0.02264
  rs2373793	Imputed	G	DOM	792	1.446	0.1627	1.051	1.989	2.265	0.0235
  rs238252	Imputed	G	ADD	799	1.66	0.1458	1.248	2.209	3.478	0.000505
  rs238252	Imputed	G	DOM	799	1.848	0.1687	1.328	2.573	3.642	0.000271
  rs2383903	Imputed	G	DOM	797	0.6249	0.1456	0.4698	0.8313	−3.229	0.001242
  rs2387945	Imputed	G	DOM	792	1.587	0.1626	1.154	2.182	2.84	0.004513
  rs2389863	Imputed	A	DOM	784	0.6722	0.1503	0.5007	0.9025	−2.643	0.008221
  rs2389866	Imputed	C	DOM	800	0.6634	0.1489	0.4955	0.8883	−2.756	0.005859
  rs2389869	Imputed	C	DOM	800	0.6634	0.1489	0.4955	0.8883	−2.756	0.005859
  rs2389870	Genotyped	C	DOM	800	0.6413	0.1561	0.4723	0.8709	−2.846	0.004433
  rs2418494	Imputed	G	ADD	777	0.8166	0.101	0.67	0.9953	−2.006	0.04483
  rs2418494	Imputed	G	GEN	777					4.805	0.0905
  rs2418541	Imputed	A	DOM	798	0.6462	0.1462	0.4852	0.8606	−2.987	0.002819
  rs2418542	Imputed	A	DOM	797	0.6489	0.1462	0.4872	0.8644	−2.957	0.003109
  rs2423556	Imputed	C	DOM	796	0.6175	0.1654	0.4465	0.8539	−2.915	0.003556
  rs2437688	Imputed	C	ADD	799	1.457	0.1639	1.056	2.008	2.294	0.02177
  rs2456809	Imputed	G	DOM	800	0.6151	0.1445	0.4634	0.8164	−3.364	0.000769
  rs2456811	Imputed	T	ADD	789	0.6292	0.1219	0.4955	0.799	−3.8	0.000144
  rs2456811	Imputed	T	DOM	789	0.6017	0.1465	0.4515	0.8019	−3.466	0.000527
  rs2476976	Imputed	C	DOM	799	1.596	0.1449	1.201	2.12	3.225	0.001258
  rs2484911	Imputed	A	DOM	797	1.56	0.1448	1.175	2.073	3.071	0.002132
  rs2488557	Imputed	C	DOM	787	0.5503	0.1765	0.3894	0.7777	−3.384	0.000713
  rs250162	Imputed	C	ADD	777	0.7333	0.1252	0.5738	0.9373	−2.477	0.01324
  rs250162	Imputed	C	DOM	777	0.6818	0.1495	0.5086	0.9139	−2.562	0.0104
  rs2560708	Imputed	T	ADD	770	0.6815	0.1471	0.5108	0.9092	−2.607	0.009133
  rs2617841	Imputed	G	DOM	737	0.679	0.1512	0.5048	0.9132	−2.56	0.01045
  rs2622499	Imputed	G	DOM	798	0.6691	0.149	0.4996	0.8961	−2.696	0.007022
  rs264129	Imputed	T	DOM	798	0.653	0.1461	0.4904	0.8695	−2.917	0.003536
  rs2642936	Imputed	T	ADD	767	1.403	0.1248	1.098	1.791	2.712	0.006694
  rs2660633	Imputed	A	DOM	800	0.6151	0.1445	0.4634	0.8164	−3.364	0.000769
  rs2660634	Imputed	C	DOM	800	0.6151	0.1445	0.4634	0.8164	−3.364	0.000769
  rs2660648	Imputed	A	ADD	790	0.6269	0.1219	0.4937	0.7961	−3.831	0.000128
  rs2660648	Imputed	A	DOM	790	0.5989	0.1465	0.4494	0.798	−3.501	0.000464
  rs2681505	Imputed	T	ADD	800	0.6338	0.1259	0.4952	0.8112	−3.621	0.000293
  rs277411	Imputed	G	DOM	797	0.346	0.3255	0.1828	0.6549	−3.261	0.001112
  rs2832634	Imputed	G	ADD	767	1.706	0.2347	1.077	2.702	2.276	0.02282
  rs2832637	Imputed	T	ADD	767	1.706	0.2347	1.077	2.702	2.276	0.02282
  rs2843167	Imputed	A	DOM	789	0.5976	0.1456	0.4493	0.795	−3.536	0.000406
  rs2876227	Imputed	C	ADD	780	1.336	0.1077	1.082	1.65	2.692	0.007104
  rs2876227	Imputed	C	GEN	780					9.11	0.01051
  rs2882097	Imputed	A	DOM	800	1.654	0.1456	1.243	2.2	3.456	0.000547
  rs2909862	Imputed	G	DOM	680	1.87	0.1696	1.341	2.608	3.692	0.000223
  rs3001945	Imputed	T	DOM	792	1.587	0.1626	1.154	2.182	2.84	0.004513
  rs3011020	Imputed	C	DOM	791	1.591	0.1626	1.157	2.188	2.856	0.004284
  rs36071725	Genotyped	C	ADD	800	1.524	0.1104	1.228	1.892	3.818	0.000134
  rs36071725	Genotyped	C	GEN	800					18.94	7.72E−05
  rs373983	Imputed	G	DOM	782	1.553	0.154	1.148	2.1	2.858	0.004263
  rs3743794	Imputed	G	DOM	797	0.587	0.1492	0.4382	0.7864	−3.571	0.000356
  rs3756154	Imputed	C	ADD	800	0.7138	0.1326	0.5504	0.9257	−2.542	0.01103
  rs3756154	Imputed	C	DOM	800	0.6634	0.1489	0.4955	0.8883	−2.756	0.005859
  rs3775850	Imputed	A	DOM	797	0.6253	0.1569	0.4598	0.8505	−2.992	0.002768
  rs3775851	Imputed	C	DOM	798	0.6341	0.1569	0.4662	0.8624	−2.903	0.003694
  rs3793044	Imputed	C	ADD	800	1.998	0.2096	1.325	3.013	3.302	0.00096
  rs3793044	Imputed	C	DOM	800	2.076	0.2229	1.341	3.213	3.276	0.001053
  rs3793053	Imputed	C	DOM	784	1.878	0.1992	1.271	2.775	3.163	0.001559
  rs3796246	Imputed	G	DOM	797	0.5889	0.193	0.4034	0.8595	−2.744	0.006063
  rs3806003	Imputed	A	ADD	800	1.998	0.2096	1.325	3.013	3.302	0.00096
  rs3806003	Imputed	A	DOM	800	2.076	0.2229	1.341	3.213	3.276	0.001053
  rs3806004	Imputed	T	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs3806010	Imputed	T	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs3806014	Imputed	T	DOM	796	1.865	0.1984	1.264	2.752	3.143	0.001675
  rs3806015	Imputed	A	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs3806018	Imputed	A	DOM	790	1.834	0.1988	1.242	2.708	3.051	0.002279
  rs3806019	Imputed	A	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs3806024	Imputed	T	DOM	784	1.878	0.1992	1.271	2.775	3.163	0.001559
  rs3915080	Imputed	A	GEN	785					10.95	0.004188
  rs3942254	Imputed	T	ADD	789	0.7293	0.107	0.5913	0.8995	−2.95	0.003182
  rs3942254	Imputed	T	DOM	789	0.6079	0.1519	0.4513	0.8187	−3.277	0.00105
  rs3945085	Imputed	A	DOM	797	1.637	0.1456	1.231	2.178	3.387	0.000706
  rs3976737	Imputed	G	ADD	753	0.5945	0.1454	0.4471	0.7905	−3.577	0.000348
  rs399485	Imputed	A	DOM	794	1.449	0.145	1.09	1.925	2.556	0.01057
  rs4029119	Imputed	G	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs4029119	Imputed	G	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs4076201	Imputed	G	GEN	776					8.852	0.01196
  rs4076201	Imputed	G	REC	776	2.978	0.3815	1.41	6.29	2.86	0.004234
  rs41395945	Imputed	G	ADD	767	1.706	0.2347	1.077	2.702	2.276	0.02282
  rs41395945	Imputed	G	DOM	767	1.77	0.2427	1.1	2.849	2.353	0.0186
  rs4146972	Genotyped	T	DOM	800	1.441	0.1516	1.071	1.94	2.41	0.01594
  rs4238087	Imputed	G	DOM	789	0.719	0.1681	0.5172	0.9995	−1.963	0.04968
  rs4251569	Imputed	T	ADD	791	0.7164	0.1513	0.5325	0.9637	−2.204	0.02753
  rs4251569	Imputed	T	DOM	791	0.7189	0.1681	0.5171	0.9993	−1.964	0.04952
  rs4273613	Imputed	T	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs4273613	Imputed	T	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs4291049	Imputed	T	REC	798	0.5495	0.1747	0.3902	0.7739	−3.428	0.000609
  rs4315598	Imputed	T	ADD	799	1.348	0.1061	1.095	1.66	2.813	0.004904
  rs4315598	Imputed	T	GEN	799					9.777	0.007533
  rs4315598	Imputed	T	REC	799	1.885	0.2107	1.247	2.849	3.009	0.002624
  rs4321395	Imputed	A	DOM	760	0.6185	0.1611	0.451	0.8482	−2.982	0.002863
  rs4321596	Genotyped	T	REC	800	2.132	0.296	1.194	3.809	2.559	0.0105
  rs4324417	Imputed	T	DOM	800	1.724	0.1627	1.254	2.372	3.349	0.000812
  rs4328619	Genotyped	G	DOM	800	0.6851	0.1653	0.4955	0.9472	−2.288	0.02212
  rs4338909	Imputed	T	ADD	798	1.366	0.1028	1.116	1.67	3.031	0.002435
  rs4370878	Imputed	G	DOM	798	1.625	0.1458	1.221	2.162	3.327	0.000877
  rs4379434	Genotyped	T	DOM	800	1.624	0.1546	1.199	2.199	3.136	0.001712
  rs4416407	Imputed	T	DOM	791	1.831	0.1801	1.287	2.606	3.359	0.000782
  rs4417899	Imputed	C	REC	793	0.544	0.18	0.3823	0.7742	−3.382	0.000721
  rs4442732	Imputed	A	ADD	658	0.6071	0.133	0.4678	0.7879	−3.752	0.000176
  rs4444612	Imputed	G	ADD	795	1.36	0.1064	1.104	1.675	2.888	0.003879
  rs4444612	Imputed	G	GEN	795					10.03	0.006632
  rs4444612	Imputed	G	REC	795	1.891	0.2107	1.251	2.858	3.023	0.002503
  rs4450660	Imputed	C	DOM	791	1.503	0.1459	1.129	2	2.791	0.005256
  rs4509702	Imputed	C	DOM	798	1.625	0.1458	1.221	2.162	3.327	0.000877
  rs4526920	Imputed	G	GEN	795					12.3	0.002134
  rs4533145	Imputed	T	DOM	788	0.4949	0.1927	0.3392	0.7219	−3.652	0.000261
  rs4557006	Imputed	A	DOM	753	0.6286	0.1619	0.4577	0.8634	−2.867	0.00414
  rs4570530	Imputed	C	DOM	798	1.625	0.1458	1.221	2.162	3.327	0.000877
  rs4615971	Imputed	C	DOM	798	1.614	0.1449	1.215	2.144	3.304	0.000953
  rs4628119	Imputed	A	DOM	800	0.6745	0.1474	0.5052	0.9004	−2.672	0.007537
  rs4664443	Imputed	G	ADD	799	0.7174	0.1085	0.5799	0.8874	−3.06	0.002211
  rs4688259	Imputed	T	DOM	792	1.832	0.1801	1.287	2.608	3.363	0.000772
  rs4688632	Imputed	G	REC	797	0.5583	0.1725	0.3981	0.783	−3.378	0.000731
  rs4695284	Imputed	A	ADD	469	2.105	0.2029	1.414	3.133	3.667	0.000245
  rs4700302	Imputed	A	ADD	725	0.5167	0.1985	0.3501	0.7624	−3.327	0.000879
  rs4702720	Imputed	A	ADD	628	0.6094	0.1416	0.4617	0.8044	−3.497	0.00047
  rs4702720	Imputed	A	DOM	628	0.5402	0.171	0.3863	0.7553	−3.601	0.000317
  rs4711091	Genotyped	G	GEN	800					13.3	0.001292
  rs4714484	Imputed	A	ADD	799	0.6694	0.1425	0.5063	0.8852	−2.816	0.004864
  rs4736802	Imputed	G	DOM	794	1.64	0.1547	1.211	2.221	3.196	0.001395
  rs4760785	Imputed	A	ADD	771	0.7218	0.1078	0.5844	0.8916	−3.025	0.002485
  rs4760785	Imputed	A	DOM	771	0.6464	0.1598	0.4726	0.8841	−2.731	0.006318
  rs4760785	Imputed	A	GEN	771					9.268	0.009717
  rs4760894	Imputed	T	ADD	771	0.7218	0.1078	0.5844	0.8916	−3.025	0.002485
  rs4760894	Imputed	T	DOM	771	0.6464	0.1598	0.4726	0.8841	−2.731	0.006318
  rs4760894	Imputed	T	GEN	771					9.268	0.009717
  rs4760895	Imputed	A	ADD	771	0.7218	0.1078	0.5844	0.8916	−3.025	0.002485
  rs4760895	Imputed	A	DOM	771	0.6464	0.1598	0.4726	0.8841	−2.731	0.006318
  rs4760895	Imputed	A	GEN	771					9.268	0.009717
  rs4764738	Imputed	A	ADD	785	1.331	0.1042	1.085	1.633	2.742	0.0061
  rs4764738	Imputed	A	GEN	785					7.557	0.02286
  rs4764974	Imputed	T	ADD	796	1.322	0.1036	1.079	1.62	2.695	0.007028
  rs4764974	Imputed	T	GEN	796					7.298	0.02602
  rs4798366	Imputed	G	REC	780	1.597	0.2447	0.9889	2.58	1.915	0.05555
  rs483159	Imputed	T	DOM	718	1.425	0.1565	1.048	1.936	2.262	0.0237
  rs4836502	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs4836507	Imputed	C	DOM	791	0.6716	0.1473	0.5032	0.8964	−2.703	0.006874
  rs4836744	Imputed	A	ADD	797	0.7163	0.1117	0.5755	0.8916	−2.988	0.002809
  rs4836744	Imputed	A	DOM	797	0.6971	0.144	0.5257	0.9245	−2.505	0.01224
  rs4848944	Genotyped	C	REC	800	0.6741	0.1744	0.4789	0.9488	−2.261	0.02373
  rs4851529	Imputed	A	DOM	798	0.6968	0.1498	0.5195	0.9346	−2.411	0.0159
  rs4851531	Imputed	T	DOM	785	0.7275	0.1515	0.5406	0.9789	−2.101	0.03565
  rs4858046	Genotyped	T	GEN	800					9.709	0.007792
  rs4878214	Imputed	A	ADD	628	0.5979	0.1405	0.454	0.7875	−3.661	0.000252
  rs4880803	Imputed	A	ADD	789	0.7753	0.1121	0.6223	0.9658	−2.27	0.02319
  rs489441	Imputed	G	ADD	748	1.446	0.1212	1.14	1.834	3.044	0.002335
  rs489441	Imputed	G	DOM	748	1.584	0.1496	1.181	2.123	3.074	0.002112
  rs4896568	Imputed	T	DOM	774	0.6713	0.1492	0.5011	0.8993	−2.672	0.007546
  rs4938851	Imputed	T	DOM	800	1.543	0.1498	1.151	2.07	2.898	0.00376
  rs4964416	Imputed	C	DOM	799	0.598	0.1645	0.4332	0.8256	−3.125	0.001776
  rs5756669	Imputed	C	DOM	800	1.724	0.1627	1.254	2.372	3.349	0.000812
  rs6033138	Imputed	C	ADD	796	1.371	0.105	1.116	1.685	3.008	0.002629
  rs6033138	Imputed	C	GEN	796					10.23	0.005998
  rs6033138	Imputed	C	REC	796	1.836	0.2034	1.232	2.736	2.987	0.002813
  rs6040619	Imputed	C	ADD	800	1.337	0.1054	1.088	1.644	2.757	0.005839
  rs6040619	Imputed	C	GEN	800					9.282	0.009648
  rs6040619	Imputed	C	REC	800	1.844	0.2095	1.223	2.78	2.92	0.003504
  rs6040625	Imputed	T	ADD	800	1.343	0.1053	1.093	1.651	2.802	0.005079
  rs6040625	Imputed	T	GEN	800					9.403	0.009081
  rs6040625	Imputed	T	REC	800	1.844	0.2095	1.223	2.78	2.92	0.003504
  rs6040630	Imputed	A	ADD	800	1.353	0.1061	1.099	1.666	2.854	0.004317
  rs6040630	Imputed	A	GEN	800					9.956	0.006888
  rs6040630	Imputed	A	REC	800	1.892	0.2107	1.252	2.859	3.026	0.002474
  rs6040633	Imputed	A	ADD	799	1.35	0.1061	1.096	1.662	2.826	0.004712
  rs6040633	Imputed	A	GEN	799					9.841	0.007297
  rs6040633	Imputed	A	REC	799	1.888	0.2106	1.249	2.853	3.016	0.002559
  rs6040634	Imputed	T	ADD	800	1.353	0.1061	1.099	1.666	2.854	0.004317
  rs6040634	Imputed	T	GEN	800					9.956	0.006888
  rs6040634	Imputed	T	REC	800	1.892	0.2107	1.252	2.859	3.026	0.002474
  rs6040636	Imputed	T	ADD	799	1.359	0.1061	1.103	1.673	2.888	0.00388
  rs6040636	Imputed	T	GEN	799					10.05	0.006571
  rs6040636	Imputed	T	REC	799	1.892	0.2107	1.252	2.859	3.027	0.002467
  rs6040638	Imputed	C	ADD	800	1.353	0.1061	1.099	1.666	2.854	0.004317
  rs6040638	Imputed	C	GEN	800					9.956	0.006888
  rs6040638	Imputed	C	REC	800	1.892	0.2107	1.252	2.859	3.026	0.002474
  rs6040644	Imputed	A	ADD	800	1.353	0.1061	1.099	1.666	2.854	0.004317
  rs6040644	Imputed	A	GEN	800					9.956	0.006888
  rs6040644	Imputed	A	REC	800	1.892	0.2107	1.252	2.859	3.026	0.002474
  rs6040667	Imputed	T	ADD	787	1.352	0.1076	1.095	1.67	2.804	0.005046
  rs6040667	Imputed	T	GEN	787					9.469	0.008785
  rs6040667	Imputed	T	REC	787	1.878	0.2152	1.232	2.864	2.93	0.003389
  rs6040668	Imputed	C	ADD	787	1.352	0.1076	1.095	1.67	2.804	0.005046
  rs6040668	Imputed	C	GEN	787					9.469	0.008785
  rs6040668	Imputed	C	REC	787	1.878	0.2152	1.232	2.864	2.93	0.003389
  rs6043066	Genotyped	G	DOM	800	1.67	0.1467	1.253	2.227	3.497	0.000471
  rs6048146	Imputed	G	DOM	800	2.46	0.3199	1.314	4.605	2.814	0.004893
  rs6082725	Genotyped	T	DOM	800	2.46	0.3199	1.314	4.605	2.814	0.004893
  rs6131206	Imputed	C	ADD	778	1.252	0.1109	1.007	1.556	2.026	0.04277
  rs6131208	Imputed	T	ADD	788	1.358	0.1075	1.1	1.676	2.846	0.004434
  rs6131208	Imputed	T	GEN	788					9.654	0.00801
  rs6131208	Imputed	T	REC	788	1.885	0.2151	1.237	2.874	2.948	0.0032
  rs6134243	Imputed	C	ADD	800	1.353	0.1061	1.099	1.666	2.854	0.004317
  rs6134243	Imputed	C	GEN	800					9.956	0.006888
  rs6134243	Imputed	C	REC	800	1.892	0.2107	1.252	2.859	3.026	0.002474
  rs6136020	Imputed	A	DOM	799	0.5431	0.1594	0.3974	0.7422	−3.831	0.000128
  rs613799	Imputed	C	DOM	686	1.64	0.1564	1.207	2.228	3.161	0.00157
  rs644041	Imputed	G	ADD	736	1.415	0.1215	1.116	1.796	2.86	0.004237
  rs644041	Imputed	G	DOM	736	1.556	0.1508	1.158	2.092	2.932	0.003363
  rs647645	Imputed	C	ADD	796	0.6924	0.1019	0.567	0.8454	−3.608	0.000308
  rs647645	Imputed	C	GEN	796					13.04	0.001476
  rs647645	Imputed	C	REC	796	0.5812	0.182	0.4068	0.8303	−2.982	0.002867
  rs6495554	Imputed	C	GEN	800					9.326	0.009436
  rs6495554	Imputed	C	REC	800	3.433	0.4298	1.478	7.972	2.87	0.004111
  rs6495555	Imputed	C	GEN	800					9.326	0.009436
  rs6495555	Imputed	C	REC	800	3.433	0.4298	1.478	7.972	2.87	0.004111
  rs6544728	Imputed	T	DOM	794	1.526	0.1458	1.147	2.032	2.901	0.003725
  rs6550705	Imputed	C	ADD	800	1.366	0.1079	1.105	1.688	2.889	0.00386
  rs6550705	Imputed	C	GEN	800					9.972	0.006832
  rs6550707	Imputed	T	GEN	797					9.958	0.00688
  rs658108	Imputed	A	DOM	798	1.56	0.1448	1.174	2.071	3.069	0.002149
  rs6593441	Imputed	A	DOM	785	1.577	0.1691	1.132	2.196	2.693	0.007076
  rs668732	Imputed	A	DOM	787	1.778	0.1671	1.281	2.467	3.444	0.000574
  rs671041	Imputed	A	DOM	798	1.56	0.1448	1.174	2.071	3.069	0.002149
  rs6719700	Imputed	A	ADD	695	1.427	0.1498	1.064	1.914	2.374	0.01759
  rs6719700	Imputed	A	DOM	695	1.536	0.1676	1.106	2.133	2.559	0.01049
  rs6722640	Imputed	T	DOM	797	0.682	0.1502	0.5081	0.9154	−2.548	0.01082
  rs6743092	Imputed	T	ADD	789	1.36	0.1049	1.108	1.671	2.935	0.003334
  rs6743092	Imputed	T	GEN	789					8.823	0.01214
  rs6743092	Imputed	T	REC	789	1.57	0.1704	1.124	2.192	2.646	0.008151
  rs6744759	Imputed	G	REC	794	1.692	0.2617	1.013	2.827	2.01	0.04442
  rs6746170	Imputed	A	DOM	797	1.528	0.1455	1.149	2.032	2.914	0.003568
  rs6759922	Imputed	A	DOM	760	0.6185	0.1611	0.451	0.8482	−2.982	0.002863
  rs6769864	Imputed	T	GEN	800					9.838	0.007307
  rs6773932	Imputed	C	GEN	782					10.92	0.004251
  rs6774353	Imputed	A	GEN	800					9.838	0.007307
  rs6781670	Imputed	C	GEN	800					9.296	0.009578
  rs6786431	Imputed	A	GEN	782					10.92	0.004251
  rs6789091	Imputed	T	GEN	782					10.92	0.004251
  rs6791296	Imputed	T	ADD	757	0.6225	0.164	0.4514	0.8586	−2.889	0.00386
  rs6792662	Imputed	G	DOM	792	1.844	0.1801	1.296	2.624	3.398	0.000678
  rs6797574	Imputed	G	GEN	782					10.92	0.004251
  rs6797882	Imputed	G	GEN	776					11.03	0.004027
  rs6805139	Imputed	G	DOM	797	1.812	0.1727	1.292	2.542	3.442	0.000577
  rs6806043	Imputed	C	ADD	800	1.366	0.1079	1.105	1.688	2.889	0.00386
  rs6806043	Imputed	C	GEN	800					9.972	0.006832
  rs6850716	Imputed	C	GEN	799					12.52	0.001916
  rs6867153	Imputed	A	REC	795	0.528	0.177	0.3733	0.7469	−3.609	0.000307
  rs687047	Imputed	C	ADD	800	0.6526	0.1561	0.4806	0.8861	−2.734	0.006248
  rs6871041	Imputed	G	DOM	666	0.6	0.1598	0.4387	0.8207	−3.196	0.001391
  rs688358	Imputed	A	ADD	795	0.6534	0.156	0.4812	0.8872	−2.727	0.006386
  rs6888012	Imputed	A	REC	795	0.528	0.177	0.3733	0.7469	−3.609	0.000307
  rs6908481	Imputed	C	REC	784	1.96	0.1947	1.338	2.871	3.458	0.000545
  rs7032231	Imputed	A	ADD	789	1.212	0.1105	0.9756	1.504	1.737	0.08246
  rs7067638	Imputed	T	DOM	795	1.6	0.1731	1.14	2.247	2.717	0.00659
  rs7077799	Imputed	A	DOM	745	1.625	0.1513	1.208	2.185	3.208	0.001335
  rs7082163	Imputed	A	ADD	800	1.58	0.1552	1.166	2.142	2.948	0.003195
  rs7082163	Imputed	A	DOM	800	1.684	0.1729	1.2	2.364	3.014	0.002574
  rs7089661	Imputed	C	DOM	800	1.62	0.1448	1.22	2.152	3.335	0.000854
  rs7101319	Imputed	C	ADD	797	1.567	0.1554	1.156	2.125	2.891	0.003836
  rs7101319	Imputed	C	DOM	797	1.667	0.1733	1.187	2.341	2.95	0.003178
  rs710832	Genotyped	A	GEN	800					10.04	0.006605
  rs710832	Genotyped	A	REC	800	0.3805	0.3178	0.2041	0.7092	−3.041	0.002357
  rs7134262	Imputed	T	GEN	796					18.44	9.88E−05
  rs7134262	Imputed	T	REC	796	2.449	0.2188	1.595	3.76	4.092	4.27E−05
  rs7134671	Imputed	T	GEN	786					6.843	0.03266
  rs7138300	Imputed	C	ADD	771	0.7218	0.1078	0.5844	0.8916	−3.025	0.002485
  rs7138300	Imputed	C	DOM	771	0.6464	0.1598	0.4726	0.8841	−2.731	0.006318
  rs7138300	Imputed	C	GEN	771					9.268	0.009717
  rs7163931	Imputed	G	GEN	800					9.326	0.009436
  rs7163931	Imputed	G	REC	800	3.433	0.4298	1.478	7.972	2.87	0.004111
  rs7171486	Genotyped	G	DOM	800	0.7681	0.1448	0.5783	1.02	−1.821	0.06855
  rs7172611	Imputed	G	GEN	800					9.499	0.008657
  rs7172611	Imputed	G	REC	800	3.433	0.4298	1.478	7.972	2.87	0.004111
  rs7172689	Imputed	T	GEN	800					9.499	0.008657
  rs7172689	Imputed	T	REC	800	3.433	0.4298	1.478	7.972	2.87	0.004111
  rs7175701	Imputed	C	GEN	799					8.043	0.01793
  rs7180245	Imputed	A	GEN	800					9.499	0.008657
  rs7180245	Imputed	A	REC	800	3.433	0.4298	1.478	7.972	2.87	0.004111
  rs7220603	Genotyped	A	ADD	800	0.7182	0.1147	0.5737	0.8992	−2.886	0.003898
  rs7282518	Imputed	T	ADD	673	1.688	0.1538	1.249	2.283	3.405	0.000662
  rs7283476	Imputed	T	ADD	800	0.3701	0.3146	0.1998	0.6857	−3.159	0.001582
  rs7283476	Imputed	T	DOM	800	0.3345	0.3297	0.1753	0.6385	−3.321	0.000898
  rs7295817	Imputed	C	GEN	795					10.28	0.005851
  rs7298255	Imputed	A	ADD	800	0.7363	0.1048	0.5997	0.9041	−2.922	0.003477
  rs7298255	Imputed	A	DOM	800	0.6348	0.1584	0.4654	0.8659	−2.87	0.004111
  rs7305832	Imputed	C	GEN	798					18.44	9.88E−05
  rs7305832	Imputed	C	REC	798	2.46	0.2188	1.602	3.777	4.113	3.91E−05
  rs7331467	Imputed	A	GEN	800					15.12	0.00052
  rs7392620	Imputed	C	ADD	783	0.7778	0.1122	0.6242	0.9691	−2.239	0.02513
  rs742827	Imputed	A	ADD	727	1.41	0.1113	1.134	1.754	3.087	0.002021
  rs742827	Imputed	A	GEN	727					10.58	0.005035
  rs742827	Imputed	A	REC	727	1.914	0.2166	1.252	2.926	2.998	0.002718
  rs7446891	Imputed	G	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs7448641	Imputed	C	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs7448641	Imputed	C	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs7484728	Imputed	T	GEN	788					6.971	0.03064
  rs7499402	Genotyped	A	ADD	800	1.746	0.1907	1.202	2.538	2.924	0.00346
  rs7529851	Imputed	A	ADD	800	0.7957	0.1062	0.6462	0.9799	−2.151	0.03144
  rs7529851	Imputed	A	GEN	800					5.275	0.07153
  rs7573951	Imputed	G	ADD	799	0.7174	0.1085	0.5799	0.8874	−3.06	0.002211
  rs7599198	Imputed	T	DOM	717	0.6201	0.1648	0.4489	0.8565	−2.9	0.003737
  rs7600050	Imputed	C	ADD	763	1.294	0.1099	1.043	1.605	2.343	0.01915
  rs7607712	Imputed	T	ADD	784	1.401	0.1287	1.088	1.803	2.618	0.008843
  rs7607712	Imputed	T	DOM	784	1.477	0.1494	1.102	1.979	2.609	0.009089
  rs7613492	Imputed	G	GEN	792					9.987	0.006783
  rs7621663	Imputed	G	ADD	749	1.413	0.113	1.132	1.763	3.057	0.002237
  rs7621663	Imputed	G	GEN	749					12.37	0.002057
  rs7621663	Imputed	G	REC	749	2.257	0.239	1.413	3.606	3.406	0.000658
  rs7626584	Imputed	G	ADD	799	0.4778	0.2123	0.3152	0.7244	−3.478	0.000505
  rs7684899	Imputed	C	ADD	800	0.7138	0.1326	0.5504	0.9257	−2.542	0.01103
  rs7684899	Imputed	C	DOM	800	0.6634	0.1489	0.4955	0.8883	−2.756	0.005859
  rs7701604	Imputed	G	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs7701604	Imputed	G	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs7703676	Imputed	C	ADD	800	0.2198	0.3906	0.1022	0.4726	−3.878	0.000105
  rs7703676	Imputed	C	DOM	800	0.2258	0.4052	0.102	0.4995	−3.673	0.00024
  rs7708491	Imputed	C	REC	797	0.5462	0.1754	0.3873	0.7703	−3.448	0.000565
  rs7711358	Imputed	A	DOM	797	0.6489	0.1462	0.4872	0.8644	−2.957	0.003109
  rs7719448	Imputed	G	REC	796	0.525	0.1769	0.3712	0.7425	−3.643	0.000269
  rs7724761	Imputed	T	REC	795	0.528	0.177	0.3733	0.7469	−3.609	0.000307
  rs7742476	Imputed	T	DOM	734	1.752	0.1551	1.293	2.374	3.615	0.0003
  rs7762993	Imputed	A	ADD	797	1.568	0.1276	1.221	2.013	3.524	0.000425
  rs7762993	Imputed	A	DOM	797	1.808	0.1517	1.343	2.434	3.904	9.47E−05
  rs7767265	Imputed	G	ADD	794	1.626	0.1195	1.287	2.056	4.068	4.74E−05
  rs7767265	Imputed	G	DOM	794	1.904	0.1484	1.424	2.547	4.34	1.43E−05
  rs7768128	Imputed	G	REC	768	0.3796	0.3438	0.1935	0.7448	−2.817	0.004846
  rs7771264	Imputed	T	DOM	769	0.6735	0.1496	0.5024	0.9029	−2.643	0.008215
  rs7773151	Genotyped	C	DOM	800	0.6804	0.1475	0.5096	0.9086	−2.61	0.009059
  rs7773210	Genotyped	A	DOM	800	0.6745	0.1474	0.5052	0.9004	−2.672	0.007537
  rs7808536	Imputed	G	DOM	793	1.395	0.1494	1.041	1.87	2.231	0.02571
  rs7843510	Genotyped	G	DOM	800	1.623	0.1544	1.199	2.197	3.137	0.001708
  rs7894867	Imputed	T	DOM	795	1.6	0.1731	1.14	2.247	2.717	0.00659
  rs7921834	Imputed	C	DOM	798	1.614	0.1449	1.215	2.144	3.304	0.000953
  rs7939893	Imputed	C	ADD	792	0.7358	0.1051	0.5988	0.904	−2.92	0.003502
  rs7939893	Imputed	C	DOM	792	0.6755	0.145	0.5084	0.8976	−2.705	0.006832
  rs7944513	Imputed	T	GEN	790					13.06	0.001463
  rs7944513	Imputed	T	REC	790	3.574	0.3533	1.788	7.143	3.605	0.000313
  rs7949720	Imputed	G	ADD	756	0.57	0.1619	0.415	0.7828	−3.472	0.000516
  rs7949720	Imputed	G	DOM	756	0.5191	0.1768	0.3671	0.7341	−3.708	0.000209
  rs7955901	Imputed	C	ADD	786	0.7383	0.1058	0.6	0.9085	−2.867	0.004143
  rs7955901	Imputed	C	DOM	786	0.6461	0.1592	0.4729	0.8826	−2.744	0.006061
  rs7956274	Imputed	T	ADD	795	0.7286	0.1054	0.5926	0.8957	−3.005	0.002655
  rs7956274	Imputed	T	DOM	795	0.6184	0.1596	0.4523	0.8456	−3.011	0.002605
  rs7956274	Imputed	T	GEN	795					9.858	0.007235
  rs7957932	Imputed	G	ADD	796	0.7518	0.1046	0.6125	0.9228	−2.729	0.006355
  rs7957932	Imputed	G	DOM	796	0.6254	0.1609	0.4562	0.8572	−2.918	0.003526
  rs7984504	Imputed	C	GEN	800					11.72	0.002847
  rs7999518	Imputed	A	REC	738	0.6515	0.1778	0.4598	0.9232	−2.409	0.01598
  rs8026245	Imputed	G	GEN	778					8.696	0.01294
  rs8026245	Imputed	G	REC	778	3.097	0.3961	1.425	6.731	2.854	0.004317
  rs8060725	Genotyped	A	ADD	800	0.7255	0.1166	0.5772	0.9118	−2.752	0.005931
  rs8103016	Genotyped	A	ADD	800	1.537	0.1267	1.199	1.97	3.391	0.000697
  rs8103016	Genotyped	A	DOM	800	1.604	0.1508	1.194	2.156	3.135	0.001718
  rs8104182	Imputed	G	ADD	799	1.45	0.1279	1.129	1.863	2.906	0.00366
  rs8104182	Imputed	G	DOM	799	1.504	0.1519	1.117	2.025	2.686	0.007239
  rs8129461	Imputed	G	ADD	800	0.3701	0.3146	0.1998	0.6857	−3.159	0.001582
  rs8129461	Imputed	G	DOM	800	0.3345	0.3297	0.1753	0.6385	−3.321	0.000898
  rs8130021	Imputed	G	ADD	800	0.3701	0.3146	0.1998	0.6857	−3.159	0.001582
  rs8130021	Imputed	G	DOM	800	0.3345	0.3297	0.1753	0.6385	−3.321	0.000898
  rs879961	Imputed	T	ADD	791	0.6288	0.1219	0.4951	0.7985	−3.805	0.000142
  rs879961	Imputed	T	DOM	791	0.6015	0.1465	0.4513	0.8016	−3.469	0.000522
  rs906353	Imputed	A	DOM	795	0.622	0.1448	0.4683	0.8261	−3.279	0.001041
  rs915491	Imputed	C	DOM	800	1.594	0.145	1.2	2.119	3.217	0.001297
  rs915493	Imputed	T	DOM	800	1.594	0.145	1.2	2.119	3.217	0.001297
  rs915494	Imputed	A	ADD	796	1.39	0.114	1.112	1.738	2.888	0.003875
  rs915494	Imputed	A	DOM	796	1.637	0.146	1.229	2.179	3.375	0.000738
  rs917295	Imputed	G	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs9284851	Imputed	A	GEN	794					10.63	0.004929
  rs9293464	Imputed	T	REC	796	0.525	0.1769	0.3712	0.7425	−3.643	0.000269
  rs9295154	Genotyped	G	DOM	800	1.438	0.161	1.049	1.972	2.255	0.02411
  rs9310221	Imputed	A	DOM	747	1.847	0.1614	1.346	2.534	3.801	0.000144
  rs9310699	Genotyped	T	GEN	800					9.296	0.009578
  rs9310700	Imputed	C	ADD	771	1.383	0.1116	1.111	1.721	2.907	0.003644
  rs9310700	Imputed	C	GEN	771					10.95	0.004186
  rs9310701	Imputed	G	GEN	797					9.958	0.00688
  rs9310704	Imputed	G	GEN	784					11.11	0.003861
  rs9319185	Imputed	C	GEN	790					12.94	0.001552
  rs9319186	Imputed	T	GEN	795					12.3	0.002134
  rs9327555	Imputed	T	DOM	800	0.6617	0.1466	0.4964	0.882	−2.816	0.004859
  rs9403367	Imputed	C	DOM	800	0.6745	0.1474	0.5052	0.9004	−2.672	0.007537
  rs9419608	Imputed	G	REC	797	1.836	0.1694	1.317	2.559	3.586	0.000336
  rs9426437	Imputed	T	DOM	760	0.5666	0.1548	0.4183	0.7675	−3.669	0.000244
  rs9454967	Imputed	G	DOM	799	1.856	0.1976	1.26	2.734	3.131	0.001743
  rs9635511	Imputed	T	DOM	791	0.5772	0.1505	0.4297	0.7753	−3.651	0.000262
  rs966583	Imputed	A	ADD	795	0.7274	0.1066	0.5903	0.8964	−2.987	0.002819
  rs966583	Imputed	A	DOM	795	0.6077	0.151	0.452	0.817	−3.298	0.000973
  rs980263	Imputed	T	GEN	796					10.4	0.00552
  rs980264	Imputed	T	GEN	796					10.4	0.00552
  rs9812206	Imputed	G	ADD	799	0.526	0.1802	0.3695	0.7488	−3.565	0.000364
  rs9812206	Imputed	G	DOM	799	0.4862	0.1936	0.3327	0.7106	−3.725	0.000196
  rs9813552	Imputed	G	ADD	800	0.5703	0.1786	0.4019	0.8093	−3.145	0.001661
  rs9813552	Imputed	G	DOM	800	0.5318	0.191	0.3657	0.7733	−3.306	0.000946
  rs9815037	Imputed	T	ADD	799	0.5621	0.1845	0.3915	0.8069	−3.123	0.001792
  rs9815037	Imputed	T	DOM	799	0.5176	0.1969	0.3519	0.7613	−3.345	0.000822
  rs9819583	Imputed	T	GEN	798					9.421	0.008999
  rs9825349	Imputed	A	ADD	798	0.5607	0.1845	0.3906	0.8049	−3.136	0.001712
  rs9825349	Imputed	A	DOM	798	0.5163	0.1969	0.351	0.7593	−3.358	0.000784
  rs9833118	Imputed	G	ADD	794	1.352	0.1082	1.094	1.672	2.791	0.005247
  rs9833118	Imputed	G	GEN	794					9.638	0.008076
  rs9834217	Imputed	T	ADD	799	0.5621	0.1845	0.3915	0.8069	−3.123	0.001792
  rs9834217	Imputed	T	DOM	799	0.5176	0.1969	0.3519	0.7613	−3.345	0.000822
  rs9838563	Imputed	C	GEN	797					9.958	0.00688
  rs9840460	Imputed	T	ADD	799	0.5621	0.1845	0.3915	0.8069	−3.123	0.001792
  rs9840460	Imputed	T	DOM	799	0.5176	0.1969	0.3519	0.7613	−3.345	0.000822
  rs9840756	Imputed	A	ADD	799	0.5621	0.1845	0.3915	0.8069	−3.123	0.001792
  rs9840756	Imputed	A	DOM	799	0.5176	0.1969	0.3519	0.7613	−3.345	0.000822
  rs9847999	Imputed	C	GEN	794					10.29	0.005829
  rs9864769	Imputed	C	GEN	797					9.958	0.00688
  rs9866421	Genotyped	C	REC	800	0.5528	0.191	0.3802	0.8038	−3.104	0.00191
  rs987296	Imputed	T	GEN	800					9.296	0.009578
  rs9881685	Imputed	A	ADD	799	0.526	0.1802	0.3695	0.7488	−3.565	0.000364
  rs9881685	Imputed	A	DOM	799	0.4862	0.1936	0.3327	0.7106	−3.725	0.000196
  rs992695	Imputed	C	ADD	790	0.6317	0.1218	0.4976	0.8019	−3.773	0.000161
  rs992695	Imputed	C	DOM	790	0.6056	0.1463	0.4546	0.8068	−3.427	0.00061
  rs9936999	Imputed	G	DOM	485	1.885	0.192	1.294	2.746	3.302	0.000961
  					PRAVA_			PLACEBO_		PLACEBO_
  			PRAVA_	PLACEBO_	A1_	PRAVA_	PRAVA_	A1_	PLACEBO_	A2_
  	HW_	ALLELE_	ALLELE_	ALLELE_	HZ_	HET_	A2_HZ	HZ_	HET_	HZ_
  SNP rs #	PVALUE	FREQ	FREQ	FREQ	COUNT	COUNT	COUNT	COUNT	COUNT	COUNT
  rs77638540	0.3047	0.0375	0.021008	0.05079	1	13	343	1	43	399
  rs72746987	1	0.04	0.019608	0.056433	0	14	343	1	48	394
  rs10021016	0.8563	0.26563	0.294118	0.242664	35	140	182	20	175	248
  rs10021016	0.8563	0.26563	0.294118	0.242664	35	140	182	20	175	248
  rs10051148	0.8139	0.34296	0.315493	0.365079	44	136	175	51	220	170
  rs10054055	0.9376	0.345	0.317927	0.366817	44	139	174	52	221	170
  rs10067895	0.6933	0.34324	0.316901	0.364679	44	137	174	52	214	170
  rs10100725	0.2765	0.17813	0.141457	0.207675	12	77	268	18	148	277
  rs10128531	0.7542	0.13612	0.159159	0.117359	7	92	234	5	86	318
  rs10181743	0.5529	0.42126	0.473837	0.37799	72	182	90	59	198	161
  rs10199127	0.4327	0.28846	0.315714	0.266279	28	165	157	32	165	233
  rs10270624	0.5731	0.20333	0.224036	0.186441	11	129	197	17	120	276
  rs1030006	0.8313	0.46926	0.495775	0.447964	96	160	99	81	234	127
  rs1031811	0.5994	0.2822	0.291785	0.274487	37	132	184	29	183	227
  rs10430870	0.1303	0.24938	0.282913	0.222348	36	130	191	22	153	268
  rs10430870	0.1303	0.24938	0.282913	0.222348	36	130	191	22	153	268
  rs10469597	0.04142	0.27267	0.308735	0.243243	43	119	170	23	152	232
  rs10469597	0.04142	0.27267	0.308735	0.243243	43	119	170	23	152	232
  rs10478919	0.7533	0.34316	0.314607	0.366213	44	136	176	52	219	170
  rs10506623	1	0.39961	0.362069	0.43007	50	152	146	74	221	134
  rs10506623	1	0.39961	0.362069	0.43007	50	152	146	74	221	134
  rs10506626	0.8818	0.39308	0.356742	0.422551	53	148	155	71	229	139
  rs10506626	0.8818	0.39308	0.356742	0.422551	53	148	155	71	229	139
  rs10509477	0.9326	0.29688	0.329132	0.27088	31	173	153	40	160	243
  rs10517918	0.7175	0.42669	0.460674	0.399321	81	166	109	67	219	156
  rs10517924	0.4338	0.45625	0.488796	0.430023	96	157	104	76	229	138
  rs10519362	1	0.17985	0.201705	0.162037	9	124	219	16	108	308
  rs10520072	0.8149	0.34563	0.317927	0.367946	44	139	174	53	220	170
  rs10737390	0.7109	0.40089	0.365819	0.429561	58	143	153	71	230	132
  rs10742851	1	0.29	0.268908	0.306998	17	158	182	50	172	221
  rs10743685	0.1392	0.39937	0.443662	0.363636	79	157	119	58	204	178
  rs10743685	0.1392	0.39937	0.443662	0.363636	79	157	119	58	204	178
  rs10749293	0.8656	0.29674	0.328652	0.270975	31	172	153	40	159	242
  rs10749294	0.7216	0.27256	0.300562	0.25	24	166	166	33	155	254
  rs10753760	0.5446	0.4094	0.456061	0.372289	71	159	100	58	193	164
  rs10753760	0.5446	0.4094	0.456061	0.372289	71	159	100	58	193	164
  rs10772362	0.2824	0.2375	0.194678	0.272009	7	125	225	32	177	234
  rs10784891	0.3414	0.44575	0.404692	0.478774	54	168	119	91	224	109
  rs10784891	0.3414	0.44575	0.404692	0.478774	54	168	119	91	224	109
  rs10784891	0.3414	0.44575	0.404692	0.478774	54	168	119	91	224	109
  rs10787923	0.8652	0.29648	0.328652	0.270455	31	172	153	40	158	242
  rs10787924	0.7885	0.27227	0.300562	0.249433	24	166	166	33	154	254
  rs10787949	1	0.29688	0.330532	0.269752	32	172	153	38	163	242
  rs10787951	1	0.29688	0.330532	0.269752	32	172	153	38	163	242
  rs10787983	0.8644	0.29261	0.32493	0.26644	30	172	155	37	161	243
  rs10794733	0.934	0.31361	0.2849	0.336782	31	138	182	47	199	189
  rs10818280	0.7332	0.29759	0.26204	0.326437	25	135	193	47	190	198
  rs10860586	0.8315	0.48995	0.523876	0.4625	97	179	80	92	223	125
  rs10860586	0.8315	0.48995	0.523876	0.4625	97	179	80	92	223	125
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  rs7529851	0.1689	0.4225	0.393557	0.445824	48	185	124	85	225	133
  rs7529851	0.1689	0.4225	0.393557	0.445824	48	185	124	85	225	133
  rs7573951	0.7083	0.38235	0.341292	0.41535	41	161	154	73	222	148
  rs7599198	0.8207	0.447	0.410938	0.476071	60	143	117	85	208	104
  rs7600050	0.6944	0.3578	0.391496	0.330569	49	169	123	46	187	189
  rs7607712	0.3346	0.2111	0.241477	0.186343	17	136	199	13	135	284
  rs7607712	0.3346	0.2111	0.241477	0.186343	17	136	199	13	135	284
  rs7613492	0.6445	0.36111	0.400568	0.329545	59	164	129	41	208	191
  rs7621663	0.6276	0.34312	0.386228	0.308434	53	152	129	32	192	191
  rs7621663	0.6276	0.34312	0.386228	0.308434	53	152	129	32	192	191
  rs7621663	0.6276	0.34312	0.386228	0.308434	53	152	129	32	192	191
  rs7626584	0.6111	0.07384	0.047619	0.095023	1	32	324	4	76	362
  rs7684899	0.03097	0.20625	0.179272	0.227991	10	108	239	14	174	255
  rs7684899	0.03097	0.20625	0.179272	0.227991	10	108	239	14	174	255
  rs7701604	0.0147	0.03563	0.015406	0.051919	0	11	346	4	38	401
  rs7701604	0.0147	0.03563	0.015406	0.051919	0	11	346	4	38	401
  rs7703676	0.0147	0.03563	0.015406	0.051919	0	11	346	4	38	401
  rs7703676	0.0147	0.03563	0.015406	0.051919	0	11	346	4	38	401
  rs7708491	1	0.48934	0.443662	0.526018	64	187	104	127	211	104
  rs7711358	0.7533	0.34316	0.314607	0.366213	44	136	176	52	219	170
  rs7719448	1	0.48807	0.440678	0.526018	62	188	104	127	211	104
  rs7724761	1	0.48805	0.44051	0.526018	62	187	104	127	211	104
  rs7742476	0.1575	0.21662	0.255319	0.185185	20	128	181	21	108	276
  rs7762993	0.3626	0.19322	0.232394	0.161765	17	131	207	17	109	316
  rs7762993	0.3626	0.19322	0.232394	0.161765	17	131	207	17	109	316
  rs7767265	0.1075	0.22922	0.27762	0.190476	27	142	184	23	122	296
  rs7767265	0.1075	0.22922	0.27762	0.190476	27	142	184	23	122	296
  rs7768128	0.2237	0.23112	0.222063	0.238663	12	131	206	35	130	254
  rs7771264	0.5527	0.23927	0.209677	0.26285	18	107	216	29	167	232
  rs7773151	0.3706	0.23063	0.20028	0.255079	17	109	231	30	166	247
  rs7773210	0.4259	0.23125	0.20028	0.256208	17	109	231	30	167	246
  rs7808536	0.5044	0.19924	0.21875	0.183673	11	132	209	17	128	296
  rs7843510	0.6638	0.42125	0.446779	0.400677	63	193	101	82	191	170
  rs7894867	0.4039	0.12075	0.142655	0.103175	7	87	260	7	77	357
  rs7921834	0.8644	0.29261	0.32493	0.26644	30	172	155	37	161	243
  rs7939893	0.01403	0.33965	0.3	0.371854	38	137	180	69	187	181
  rs7939893	0.01403	0.33965	0.3	0.371854	38	137	180	69	187	181
  rs7944513	0.5615	0.24304	0.271307	0.22032	31	129	192	12	169	257
  rs7944513	0.5615	0.24304	0.271307	0.22032	31	129	192	12	169	257
  rs7949720	0.8773	0.13624	0.102985	0.162708	5	59	271	8	121	292
  rs7949720	0.8773	0.13624	0.102985	0.162708	5	59	271	8	121	292
  rs7955901	0.389	0.4542	0.416193	0.485023	60	173	119	96	229	109
  rs7955901	0.389	0.4542	0.416193	0.485023	60	173	119	96	229	109
  rs7956274	0.4324	0.46101	0.421127	0.493182	63	173	119	100	234	106
  rs7956274	0.4324	0.46101	0.421127	0.493182	63	173	119	100	234	106
  rs7956274	0.4324	0.46101	0.421127	0.493182	63	173	119	100	234	106
  rs7957932	0.5703	0.47173	0.435211	0.501134	69	171	115	104	234	103
  rs7957932	0.5703	0.47173	0.435211	0.501134	69	171	115	104	234	103
  rs7984504	0.1757	0.2975	0.341737	0.261851	45	154	158	34	164	245
  rs7999518	0.2381	0.48238	0.459877	0.5	65	168	91	115	184	115
  rs8026245	1	0.20373	0.227666	0.184455	22	114	211	10	139	282
  rs8026245	1	0.20373	0.227666	0.184455	22	114	211	10	139	282
  rs8060725	0.09267	0.30125	0.266106	0.329571	18	154	185	44	204	195
  rs8103016	0.5109	0.2025	0.239496	0.172686	22	127	208	14	125	304
  rs8103016	0.5109	0.2025	0.239496	0.172686	22	127	208	14	125	304
  rs8104182	0.4289	0.19462	0.226124	0.1693	20	121	215	14	122	307
  rs8104182	0.4289	0.19462	0.226124	0.1693	20	121	215	14	122	307
  rs8129461	0.3047	0.0375	0.019608	0.051919	1	12	344	1	44	398
  rs8129461	0.3047	0.0375	0.019608	0.051919	1	12	344	1	44	398
  rs8130021	0.3047	0.0375	0.019608	0.051919	1	12	344	1	44	398
  rs8130021	0.3047	0.0375	0.019608	0.051919	1	12	344	1	44	398
  rs879961	0.8526	0.2579	0.210826	0.295455	14	120	217	37	186	217
  rs879961	0.8526	0.2579	0.210826	0.295455	14	120	217	37	186	217
  rs906353	0.6019	0.28428	0.239496	0.320776	19	133	205	42	197	199
  rs915491	0.7887	0.27188	0.302521	0.247178	25	166	166	32	155	256
  rs915493	0.7887	0.27188	0.302521	0.247178	25	166	166	32	155	256
  rs915494	0.932	0.2946	0.329577	0.26644	32	170	153	36	163	242
  rs915494	0.932	0.2946	0.329577	0.26644	32	170	153	36	163	242
  rs917295	0.8149	0.34563	0.317927	0.367946	44	139	174	53	220	170
  rs9284851	0.7057	0.3772	0.415014	0.346939	65	163	125	45	216	180
  rs9293464	1	0.48807	0.440678	0.526018	62	188	104	127	211	104
  rs9295154	0.5656	0.14375	0.165266	0.126411	8	102	247	6	100	337
  rs9310221	0.2965	0.42838	0.465774	0.39781	66	181	89	78	171	162
  rs9310699	0.7594	0.36125	0.397759	0.331828	60	164	133	42	210	191
  rs9310700	0.4286	0.35019	0.390671	0.317757	54	160	129	35	202	191
  rs9310700	0.4286	0.35019	0.390671	0.317757	54	160	129	35	202	191
  rs9310701	0.821	0.37641	0.412676	0.347285	65	163	127	46	215	181
  rs9310704	0.6466	0.37181	0.410511	0.340278	63	163	126	42	210	180
  rs9319185	0.3434	0.29177	0.338028	0.254023	43	154	158	30	161	244
  rs9319186	0.2253	0.28616	0.331461	0.249431	42	152	162	30	159	250
  rs9327555	0.8149	0.34563	0.317927	0.367946	44	139	174	53	220	170
  rs9403367	0.4259	0.23125	0.20028	0.256208	17	109	231	30	167	246
  rs9419608	0.9435	0.48996	0.533708	0.454649	108	164	84	84	233	124
  rs9426437	0.5994	0.40921	0.3739	0.437947	59	137	145	72	223	124
  rs9454967	0.8332	0.09199	0.115169	0.073363	4	74	278	3	59	381
  rs9635511	0.7663	0.39444	0.351275	0.429224	50	148	155	75	226	137
  rs966583	1	0.39371	0.355932	0.424036	49	154	151	74	226	141
  rs966583	1	0.39371	0.355932	0.424036	49	154	151	74	226	141
  rs980263	0.7627	0.37563	0.412676	0.345805	65	163	127	45	215	181
  rs980264	0.7627	0.37563	0.412676	0.345805	65	163	127	45	215	181
  rs9812206	0.4346	0.10075	0.070028	0.125566	3	44	310	7	97	338
  rs9812206	0.4346	0.10075	0.070028	0.125566	3	44	310	7	97	338
  rs9813552	0.6984	0.10125	0.07423	0.123025	3	47	307	6	97	340
  rs9813552	0.6984	0.10125	0.07423	0.123025	3	47	307	6	97	340
  rs9815037	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9815037	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9819583	0.7593	0.36153	0.398876	0.331448	60	164	132	42	209	191
  rs9825349	0.6792	0.09461	0.06882	0.115385	3	43	310	5	92	345
  rs9825349	0.6792	0.09461	0.06882	0.115385	3	43	310	5	92	345
  rs9833118	0.4927	0.3665	0.404494	0.335616	60	168	128	42	210	186
  rs9833118	0.4927	0.3665	0.404494	0.335616	60	168	128	42	210	186
  rs9834217	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9834217	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9838563	0.821	0.37641	0.412676	0.347285	65	163	127	46	215	181
  rs9840460	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9840460	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9840756	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9840756	0.6789	0.09449	0.06882	0.115124	3	43	310	5	92	346
  rs9847999	0.7623	0.37657	0.412429	0.347727	65	162	127	45	216	179
  rs9864769	0.821	0.37641	0.412676	0.347285	65	163	127	46	215	181
  rs9866421	0.6672	0.44063	0.411765	0.463883	50	194	113	102	207	134
  rs987296	0.7594	0.36125	0.397759	0.331828	60	164	133	42	210	191
  rs9881685	0.4346	0.10075	0.070028	0.125566	3	44	310	7	97	338
  rs9881685	0.4346	0.10075	0.070028	0.125566	3	44	310	7	97	338
  rs992695	0.7811	0.25949	0.212857	0.296591	14	121	215	37	187	216
  rs992695	0.7811	0.25949	0.212857	0.296591	14	121	215	37	187	216
  rs9936999	0.4247	0.35052	0.389952	0.320652	22	119	68	33	111	132

• TABLE 15
  		ALLELE
  SNP rs #	SOURCE	(A1)	MODEL	NMISS	OR	SE	L95	U95	STAT	P
  rs77638540	Genotyped	T	DOM	431	0.6846	0.4051	0.3095	1.515	−0.935	0.3497
  rs72746987	Genotyped	A	DOM	431	0.3415	0.4723	0.1353	0.8617	−2.275	0.02291
  rs10021016	Genotyped	G	GEN	431					4.358	0.1131
  rs10021016	Genotyped	G	REC	431	2.151	0.4014	0.9794	4.724	1.908	0.05637
  rs10051148	Imputed	C	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs10054055	Imputed	T	DOM	431	0.7019	0.1964	0.4777	1.031	−1.803	0.0714
  rs10067895	Imputed	A	DOM	423	0.6884	0.1986	0.4665	1.016	−1.88	0.0601
  rs10100725	Imputed	C	DOM	431	0.6909	0.2229	0.4464	1.069	−1.659	0.09719
  rs10128531	Imputed	T	ADD	422	1.446	0.1929	0.9906	2.11	1.911	0.05601
  rs10181743	Imputed	G	ADD	419	1.259	0.1434	0.9504	1.668	1.605	0.1084
  rs10199127	Imputed	T	DOM	426	1.892	0.1994	1.28	2.797	3.197	0.00139
  rs10270624	Imputed	G	DOM	426	1.873	0.2081	1.245	2.816	3.014	0.00258
  rs1030006	Imputed	G	REC	431	1.973	0.2532	1.201	3.24	2.684	0.00728
  rs1031811	Imputed	A	REC	425	1.901	0.3376	0.9811	3.684	1.903	0.057
  rs10430870	Genotyped	G	GEN	431					1.662	0.4357
  rs10430870	Genotyped	G	REC	431	1.672	0.4618	0.6765	4.134	1.114	0.2654
  rs10469597	Imputed	A	GEN	397					5.33	0.06962
  rs10469597	Imputed	A	REC	397	2.363	0.3863	1.108	5.039	2.226	0.02598
  rs10478919	Imputed	G	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs10506623	Imputed	C	ADD	431	0.6851	0.1503	0.5103	0.9198	−2.516	0.01187
  rs10506623	Imputed	C	DOM	431	0.6216	0.2072	0.4141	0.9329	−2.295	0.02171
  rs10506626	Imputed	A	ADD	430	0.644	0.1506	0.4794	0.8651	−2.922	0.00348
  rs10506626	Imputed	A	DOM	430	0.5681	0.2056	0.3796	0.85	−2.75	0.00596
  rs10509477	Imputed	T	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs10517918	Imputed	G	REC	424	2.104	0.2569	1.272	3.481	2.896	0.00378
  rs10517924	Imputed	A	REC	430	1.646	0.2374	1.033	2.621	2.098	0.03593
  rs10519362	Imputed	G	DOM	431	1.479	0.2285	0.9448	2.314	1.711	0.087
  rs10520072	Imputed	T	DOM	429	0.6749	0.197	0.4587	0.993	−1.996	0.04596
  rs10737390	Imputed	T	DOM	426	0.6833	0.203	0.459	1.017	−1.876	0.06061
  rs10742851	Imputed	T	REC	431	0.2879	0.5067	0.1066	0.7773	−2.457	0.014
  rs10743685	Imputed	G	GEN	431					4.792	0.0911
  rs10743685	Imputed	G	REC	431	1.602	0.2855	0.9156	2.803	1.651	0.09875
  rs10749293	Imputed	G	DOM	431	1.52	0.1971	1.033	2.237	2.125	0.03357
  rs10749294	Imputed	A	DOM	431	1.505	0.1973	1.022	2.216	2.073	0.03821
  rs10753760	Imputed	T	ADD	406	1.468	0.1459	1.103	1.954	2.632	0.00849
  rs10753760	Imputed	T	GEN	406					6.957	0.03085
  rs10772362	Imputed	T	ADD	431	0.6724	0.1684	0.4834	0.9355	−2.356	0.01848
  rs10784891	Imputed	C	ADD	429	0.7576	0.1448	0.5705	1.006	−1.918	0.05515
  rs10784891	Imputed	C	DOM	429	0.5886	0.2107	0.3895	0.8896	−2.516	0.01189
  rs10784891	Imputed	C	GEN	429					6.516	0.03846
  rs10787923	Imputed	G	DOM	430	1.509	0.1972	1.025	2.221	2.086	0.03699
  rs10787924	Imputed	T	DOM	431	1.505	0.1973	1.022	2.216	2.073	0.03821
  rs10787949	Imputed	A	DOM	430	1.433	0.1969	0.9742	2.108	1.827	0.06765
  rs10787951	Imputed	G	DOM	430	1.433	0.1969	0.9742	2.108	1.827	0.06765
  rs10787983	Imputed	C	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs10794733	Imputed	C	ADD	421	0.7588	0.1519	0.5634	1.022	−1.818	0.06914
  rs10818280	Imputed	C	DOM	426	0.6701	0.1985	0.4541	0.9889	−2.016	0.04375
  rs10860586	Imputed	A	ADD	430	1.512	0.1414	1.146	1.995	2.923	0.00347
  rs10860586	Imputed	A	GEN	430					8.948	0.0114
  rs10870473	Imputed	A	ADD	182	0.6204	0.2357	0.3909	0.9846	−2.026	0.04278
  rs10870473	Imputed	A	DOM	182	0.4859	0.3065	0.2665	0.886	−2.355	0.01853
  rs10879240	Imputed	C	ADD	430	0.7653	0.1438	0.5773	1.014	−1.86	0.06286
  rs10879240	Imputed	C	GEN	430					6.525	0.03829
  rs10879242	Imputed	A	ADD	431	0.6996	0.1493	0.5222	0.9374	−2.393	0.0167
  rs10879242	Imputed	A	DOM	431	0.6354	0.2073	0.4232	0.9539	−2.188	0.02869
  rs10879245	Imputed	G	ADD	431	0.6996	0.1493	0.5222	0.9374	−2.393	0.0167
  rs10879245	Imputed	G	DOM	431	0.6354	0.2073	0.4232	0.9539	−2.188	0.02869
  rs10879249	Imputed	T	ADD	430	0.6776	0.1506	0.5044	0.9103	−2.584	0.00976
  rs10879249	Imputed	T	DOM	430	0.6103	0.2074	0.4065	0.9164	−2.381	0.01726
  rs10886429	Imputed	A	DOM	429	1.47	0.1974	0.9985	2.165	1.952	0.05092
  rs10886449	Imputed	G	DOM	430	1.441	0.1971	0.9794	2.121	1.854	0.06367
  rs10886451	Imputed	G	DOM	430	1.441	0.1971	0.9794	2.121	1.854	0.06367
  rs10886452	Imputed	A	DOM	430	1.433	0.1969	0.9742	2.108	1.827	0.06765
  rs10886456	Imputed	G	DOM	430	1.441	0.1971	0.9794	2.121	1.854	0.06367
  rs10886463	Imputed	C	DOM	431	1.444	0.1968	0.9818	2.123	1.867	0.06193
  rs10886465	Imputed	A	DOM	431	1.444	0.1968	0.9818	2.123	1.867	0.06193
  rs10886526	Imputed	C	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs10922903	Imputed	C	REC	430	0.6266	0.2724	0.3674	1.069	−1.716	0.08622
  rs10941126	Imputed	G	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs10941126	Imputed	G	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs10947980	Imputed	G	ADD	431	0.6089	0.157	0.4476	0.8282	−3.161	0.00157
  rs11059376	Imputed	T	ADD	412	1.592	0.1898	1.097	2.309	2.45	0.01428
  rs11072995	Imputed	T	GEN	430					5.185	0.07483
  rs11072995	Imputed	T	REC	430	2.796	0.4515	1.154	6.774	2.277	0.0228
  rs11081202	Genotyped	G	GEN	431					6.987	0.0304
  rs11081202	Genotyped	G	REC	431	2.426	0.3357	1.256	4.684	2.64	0.00829
  rs110965	Imputed	C	GEN	413					4.153	0.1254
  rs11124962	Imputed	A	DOM	431	1.812	0.2023	1.219	2.693	2.937	0.00331
  rs1116596	Imputed	T	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs11178531	Imputed	A	ADD	431	0.7781	0.1437	0.5871	1.031	−1.746	0.0808
  rs11178531	Imputed	A	DOM	431	0.6138	0.212	0.4051	0.93	−2.303	0.0213
  rs11178583	Imputed	A	ADD	430	0.6776	0.1506	0.5044	0.9103	−2.584	0.00976
  rs11178583	Imputed	A	DOM	430	0.6103	0.2074	0.4065	0.9164	−2.381	0.01726
  rs11178589	Imputed	T	ADD	431	0.6759	0.1506	0.5031	0.908	−2.601	0.0093
  rs11178589	Imputed	T	DOM	431	0.6066	0.2072	0.4042	0.9105	−2.413	0.01583
  rs11178594	Imputed	C	ADD	431	0.6841	0.1503	0.5096	0.9184	−2.527	0.01152
  rs11178594	Imputed	C	DOM	431	0.62	0.207	0.4133	0.9302	−2.31	0.0209
  rs11178602	Imputed	T	ADD	431	0.6841	0.1503	0.5096	0.9184	−2.527	0.01152
  rs11178602	Imputed	T	DOM	431	0.62	0.207	0.4133	0.9302	−2.31	0.0209
  rs11178648	Imputed	T	ADD	431	0.6858	0.1487	0.5125	0.9178	−2.537	0.01119
  rs11178648	Imputed	T	DOM	431	0.6021	0.2055	0.4025	0.9008	−2.468	0.01358
  rs11198877	Imputed	T	DOM	431	1.444	0.1968	0.9818	2.123	1.867	0.06193
  rs11198942	Imputed	T	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs11221075	Imputed	A	ADD	426	0.7175	0.2252	0.4614	1.116	−1.474	0.1405
  rs11242020	Imputed	T	DOM	430	0.7107	0.1967	0.4834	1.045	−1.736	0.08258
  rs11242021	Imputed	T	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs11242022	Imputed	T	DOM	428	0.6944	0.1971	0.4719	1.022	−1.85	0.06431
  rs11242023	Imputed	T	DOM	428	0.6944	0.1971	0.4719	1.022	−1.85	0.06431
  rs1149349	Imputed	T	DOM	431	1.606	0.2234	1.037	2.489	2.122	0.03382
  rs1149350	Imputed	A	ADD	430	1.546	0.1741	1.099	2.176	2.504	0.0123
  rs1149350	Imputed	A	DOM	430	1.835	0.2102	1.215	2.77	2.886	0.0039
  rs11576627	Imputed	T	ADD	427	1.4	0.1931	0.9592	2.045	1.744	0.08112
  rs11576627	Imputed	T	DOM	427	1.426	0.2259	0.9158	2.22	1.571	0.1162
  rs11630050	Imputed	G	GEN	431					6.07	0.04808
  rs11630050	Imputed	G	REC	431	2.977	0.4471	1.239	7.15	2.44	0.01469
  rs11633024	Imputed	C	GEN	431					6.07	0.04808
  rs11633024	Imputed	C	REC	431	2.977	0.4471	1.239	7.15	2.44	0.01469
  rs11636298	Imputed	G	GEN	431					6.084	0.04773
  rs11636298	Imputed	G	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs11637363	Imputed	C	GEN	430					6.108	0.04718
  rs11637363	Imputed	C	REC	430	2.964	0.4471	1.234	7.119	2.43	0.01509
  rs11637813	Imputed	A	GEN	431					6.07	0.04808
  rs11637813	Imputed	A	REC	431	2.977	0.4471	1.239	7.15	2.44	0.01469
  rs11638043	Imputed	C	GEN	430					6.108	0.04718
  rs11638043	Imputed	C	REC	430	2.964	0.4471	1.234	7.119	2.43	0.01509
  rs11638115	Imputed	A	GEN	430					5.185	0.07483
  rs11638115	Imputed	A	REC	430	2.796	0.4515	1.154	6.774	2.277	0.0228
  rs11638444	Imputed	C	GEN	431					6.093	0.04752
  rs11682946	Imputed	A	ADD	96	5.356	0.4472	2.229	12.87	3.753	0.00018
  rs11682946	Imputed	A	DOM	96	5.538	0.4642	2.23	13.76	3.688	0.00023
  rs11717157	Imputed	T	ADD	430	1.45	0.1393	1.104	1.906	2.67	0.00759
  rs11717157	Imputed	T	GEN	430					7.13	0.0283
  rs11724055	Imputed	A	DOM	431	0.7804	0.2073	0.5199	1.172	−1.196	0.2317
  rs11743355	Imputed	C	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs11743355	Imputed	C	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs11746806	Imputed	T	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs11746806	Imputed	T	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs11746959	Imputed	T	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs11746959	Imputed	T	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs11749272	Imputed	T	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs11839636	Imputed	C	GEN	431					7.984	0.01846
  rs11839785	Imputed	C	GEN	431					7.984	0.01846
  rs11853619	Imputed	C	GEN	431					6.084	0.04773
  rs11853619	Imputed	C	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs11856780	Imputed	A	GEN	431					6.084	0.04773
  rs11856780	Imputed	A	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs11901899	Imputed	A	DOM	426	1.822	0.199	1.234	2.692	3.016	0.00256
  rs11903290	Imputed	C	REC	425	1.901	0.3376	0.9811	3.684	1.903	0.057
  rs11909480	Imputed	G	ADD	431	0.5964	0.404	0.2701	1.317	−1.279	0.2008
  rs11909480	Imputed	G	DOM	431	0.61	0.4187	0.2685	1.386	−1.181	0.2377
  rs11910289	Imputed	T	ADD	428	2.254	0.3513	1.132	4.487	2.313	0.02074
  rs11910289	Imputed	T	DOM	428	2.226	0.3621	1.095	4.527	2.21	0.02707
  rs11920375	Genotyped	C	GEN	431					6.381	0.04115
  rs11926319	Imputed	G	DOM	429	0.5229	0.2621	0.3128	0.874	−2.474	0.01336
  rs11933744	Imputed	T	REC	431	3.01	0.47	1.198	7.563	2.345	0.01904
  rs11934919	Imputed	C	REC	431	3.01	0.47	1.198	7.563	2.345	0.01904
  rs11934957	Imputed	C	REC	431	3.01	0.47	1.198	7.563	2.345	0.01904
  rs11959206	Imputed	A	REC	428	0.5862	0.2628	0.3502	0.9812	−2.032	0.04213
  rs12038613	Imputed	C	REC	429	0.5999	0.2756	0.3495	1.03	−1.854	0.06381
  rs12151417	Imputed	T	DOM	428	1.573	0.1977	1.067	2.317	2.29	0.02204
  rs12153185	Imputed	T	DOM	426	0.6973	0.1977	0.4733	1.027	−1.824	0.06815
  rs12182651	Imputed	T	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs12235345	Imputed	C	DOM	430	1.42	0.2727	0.8321	2.423	1.286	0.1985
  rs12324786	Imputed	T	GEN	430					5.185	0.07483
  rs12324786	Imputed	T	REC	430	2.796	0.4515	1.154	6.774	2.277	0.0228
  rs12336958	Imputed	G	DOM	403	1.46	0.211	0.9657	2.208	1.794	0.07276
  rs12407412	Imputed	C	ADD	431	1.382	0.1928	0.9468	2.016	1.676	0.09367
  rs12407412	Imputed	C	DOM	431	1.401	0.2256	0.9007	2.181	1.496	0.1346
  rs12418971	Imputed	C	GEN	423					1.464	0.481
  rs12418971	Imputed	C	REC	423	1.699	0.4623	0.6866	4.204	1.147	0.2515
  rs1241967	Imputed	T	REC	431	0.5915	0.3332	0.3078	1.136	−1.576	0.115
  rs12420184	Imputed	G	DOM	430	0.6518	0.2209	0.4227	1.005	−1.938	0.05266
  rs12433968	Imputed	T	DOM	396	0.7213	0.2052	0.4825	1.078	−1.592	0.1114
  rs12445477	Imputed	A	DOM	423	0.4063	0.2966	0.2272	0.7267	−3.036	0.0024
  rs12447191	Genotyped	T	ADD	431	0.6489	0.1758	0.4598	0.9158	−2.461	0.01387
  rs12447191	Genotyped	T	DOM	431	0.5081	0.2092	0.3372	0.7656	−3.237	0.00121
  rs12465349	Imputed	A	REC	426	1.587	0.2245	1.022	2.464	2.056	0.03975
  rs1247340	Imputed	C	ADD	431	1.51	0.1734	1.075	2.122	2.377	0.01746
  rs1247340	Imputed	C	DOM	431	1.767	0.2092	1.173	2.663	2.721	0.0065
  rs1247341	Imputed	C	ADD	430	1.524	0.1738	1.084	2.143	2.426	0.01527
  rs1247341	Imputed	C	DOM	430	1.795	0.2098	1.19	2.707	2.788	0.0053
  rs1247343	Imputed	C	DOM	430	1.681	0.2249	1.081	2.612	2.308	0.02099
  rs12509758	Imputed	C	DOM	430	1.856	0.204	1.244	2.768	3.03	0.00245
  rs12515472	Imputed	A	DOM	431	1.531	0.205	1.024	2.287	2.076	0.03785
  rs12548906	Imputed	G	ADD	420	1.496	0.1799	1.052	2.129	2.241	0.02504
  rs12596240	Imputed	G	DOM	430	0.6708	0.2061	0.4479	1.005	−1.937	0.05268
  rs12618781	Imputed	A	DOM	407	0.5446	0.2216	0.3528	0.8408	−2.743	0.00609
  rs12678600	Imputed	A	DOM	431	0.6479	0.1972	0.4402	0.9536	−2.201	0.02773
  rs12692229	Imputed	T	ADD	430	1.315	0.1467	0.9861	1.753	1.864	0.06226
  rs12713324	Imputed	T	DOM	427	1.584	0.1981	1.074	2.335	2.321	0.02028
  rs12719415	Imputed	T	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs12820589	Imputed	G	ADD	418	1.758	0.1836	1.227	2.519	3.073	0.00212
  rs12820589	Imputed	G	DOM	418	1.936	0.214	1.273	2.946	3.088	0.00202
  rs12831292	Imputed	G	ADD	431	0.6841	0.1503	0.5096	0.9184	−2.527	0.01152
  rs12831292	Imputed	G	DOM	431	0.62	0.207	0.4133	0.9302	−2.31	0.0209
  rs13012636	Imputed	G	REC	425	1.901	0.3376	0.9811	3.684	1.903	0.057
  rs13038146	Imputed	C	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs13038146	Imputed	C	GEN	431					6.605	0.0368
  rs13038146	Imputed	C	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs13089860	Imputed	A	DOM	358	0.6221	0.23	0.3963	0.9764	−2.064	0.03904
  rs13102419	Imputed	T	REC	429	1.668	0.2387	1.045	2.663	2.144	0.03201
  rs13194907	Imputed	A	ADD	431	1.964	0.3063	1.077	3.579	2.203	0.02757
  rs13194907	Imputed	A	DOM	431	2.136	0.3162	1.15	3.97	2.401	0.01635
  rs13195745	Imputed	A	ADD	431	1.964	0.3063	1.077	3.579	2.203	0.02757
  rs13195745	Imputed	A	DOM	431	2.136	0.3162	1.15	3.97	2.401	0.01635
  rs13265054	Imputed	T	DOM	421	0.6754	0.199	0.4573	0.9976	−1.972	0.04863
  rs13273002	Imputed	A	GEN	429					3.598	0.1655
  rs13282131	Imputed	C	ADD	431	1.415	0.1363	1.084	1.849	2.549	0.0108
  rs13282131	Imputed	C	GEN	431					6.498	0.03882
  rs13282131	Imputed	C	REC	431	1.595	0.2279	1.02	2.493	2.048	0.04058
  rs1330052	Imputed	G	GEN	431					11.32	0.00349
  rs1335721	Imputed	A	REC	429	0.5999	0.2756	0.3495	1.03	−1.854	0.06381
  rs1336382	Imputed	T	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs1336383	Imputed	T	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs1336407	Imputed	T	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs1336409	Imputed	T	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs1336596	Imputed	A	DOM	430	0.6728	0.2004	0.4543	0.9965	−1.978	0.04797
  rs13387284	Imputed	A	DOM	400	0.5278	0.2223	0.3414	0.816	−2.875	0.00404
  rs13401462	Imputed	C	DOM	424	2.137	0.2339	1.351	3.38	3.245	0.00117
  rs13409045	Imputed	T	ADD	431	0.6931	0.1457	0.521	0.9221	−2.517	0.01184
  rs1349284	Imputed	C	GEN	431					7.563	0.02279
  rs1355715	Imputed	T	ADD	430	0.5755	0.3625	0.2828	1.171	−1.524	0.1275
  rs1357696	Imputed	A	GEN	426					5.96	0.05078
  rs1357698	Imputed	A	GEN	426					5.96	0.05078
  rs1357699	Imputed	T	GEN	426					5.96	0.05078
  rs1363273	Imputed	C	REC	404	0.5817	0.2679	0.344	0.9834	−2.023	0.04312
  rs1373601	Imputed	A	DOM	400	0.5287	0.2065	0.3527	0.7925	−3.086	0.00203
  rs1375829	Imputed	C	GEN	431					7.563	0.02279
  rs1395748	Imputed	G	DOM	431	0.6603	0.1967	0.4491	0.9708	−2.11	0.03482
  rs1414865	Imputed	T	DOM	430	1.433	0.1969	0.9742	2.108	1.827	0.06765
  rs1414873	Imputed	A	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs1414876	Imputed	C	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs1424643	Imputed	G	ADD	423	1.554	0.1651	1.124	2.148	2.669	0.00761
  rs1424643	Imputed	G	DOM	423	1.592	0.199	1.078	2.351	2.336	0.01947
  rs1424648	Imputed	T	DOM	431	1.619	0.1972	1.1	2.383	2.444	0.01451
  rs1429321	Imputed	A	DOM	426	1.545	0.1979	1.048	2.277	2.198	0.02793
  rs1429326	Imputed	T	ADD	423	1.514	0.1654	1.094	2.093	2.505	0.01223
  rs1429326	Imputed	T	DOM	423	1.573	0.1984	1.066	2.321	2.284	0.02236
  rs1444741	Imputed	A	DOM	407	0.5155	0.205	0.3449	0.7703	−3.233	0.00122
  rs1449916	Imputed	C	DOM	338	0.4287	0.2519	0.2617	0.7025	−3.362	0.00077
  rs1459523	Imputed	A	ADD	430	1.45	0.1393	1.104	1.906	2.67	0.00759
  rs1459523	Imputed	A	GEN	430					7.13	0.0283
  rs1466352	Imputed	T	GEN	431					6.792	0.0335
  rs1466353	Imputed	G	GEN	431					6.792	0.0335
  rs1476714	Imputed	A	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs1486723	Imputed	C	REC	431	0.6161	0.3308	0.3222	1.178	−1.464	0.1431
  rs1495375	Imputed	A	ADD	431	0.6996	0.1493	0.5222	0.9374	−2.393	0.0167
  rs1495375	Imputed	A	DOM	431	0.6354	0.2073	0.4232	0.9539	−2.188	0.02869
  rs1495381	Imputed	T	GEN	431					4.34	0.1142
  rs1495381	Imputed	T	REC	431	1.661	0.2511	1.015	2.717	2.021	0.04331
  rs1498061	Imputed	C	ADD	201	0.614	0.2646	0.3655	1.031	−1.843	0.06527
  rs1498992	Imputed	G	DOM	430	0.7209	0.1965	0.4905	1.06	−1.666	0.09577
  rs1499001	Imputed	T	DOM	428	0.7112	0.1982	0.4823	1.049	−1.719	0.08562
  rs1512988	Imputed	A	ADD	429	0.6768	0.1508	0.5037	0.9096	−2.589	0.00964
  rs1512988	Imputed	A	DOM	429	0.6068	0.2078	0.4038	0.9117	−2.405	0.01618
  rs1512989	Imputed	T	ADD	429	0.6768	0.1508	0.5037	0.9096	−2.589	0.00964
  rs1512989	Imputed	T	DOM	429	0.6068	0.2078	0.4038	0.9117	−2.405	0.01618
  rs1512991	Imputed	T	ADD	431	0.7609	0.1446	0.5731	1.01	−1.89	0.05873
  rs1512991	Imputed	T	DOM	431	0.5996	0.2103	0.3971	0.9055	−2.432	0.01501
  rs1512991	Imputed	T	GEN	431					6.036	0.04889
  rs1524303	Imputed	T	GEN	429					6.951	0.03095
  rs1524306	Imputed	C	ADD	431	1.457	0.1392	1.109	1.914	2.705	0.00682
  rs1524306	Imputed	C	GEN	431					7.32	0.02573
  rs1524310	Imputed	G	ADD	428	1.471	0.1406	1.117	1.937	2.744	0.00606
  rs1524310	Imputed	G	GEN	428					7.531	0.02315
  rs1524321	Imputed	C	GEN	423					7.53	0.02317
  rs1527059	Imputed	A	DOM	428	0.7558	0.266	0.4487	1.273	−1.052	0.2927
  rs152707	Imputed	A	ADD	431	0.7681	0.1426	0.5808	1.016	−1.85	0.06428
  rs152707	Imputed	A	GEN	431					3.606	0.1648
  rs152712	Genotyped	C	ADD	431	0.7606	0.1429	0.5748	1.007	−1.914	0.05557
  rs152712	Genotyped	C	GEN	431					3.917	0.1411
  rs1533994	Imputed	T	GEN	431					6.792	0.0335
  rs1535866	Imputed	G	DOM	431	1.83	0.206	1.222	2.74	2.933	0.00336
  rs1563773	Imputed	T	GEN	429					6.416	0.04044
  rs1563774	Imputed	T	GEN	431					6.792	0.0335
  rs1567740	Imputed	T	ADD	430	0.6776	0.1506	0.5044	0.9103	−2.584	0.00976
  rs1567740	Imputed	T	DOM	430	0.6103	0.2074	0.4065	0.9164	−2.381	0.01726
  rs1572573	Imputed	A	DOM	413	1.458	0.2093	0.9676	2.198	1.802	0.07148
  rs1577497	Imputed	C	REC	429	0.5999	0.2756	0.3495	1.03	−1.854	0.06381
  rs1581514	Imputed	T	ADD	418	1.482	0.1411	1.124	1.954	2.79	0.00527
  rs1581514	Imputed	T	GEN	418					7.786	0.02039
  rs1582321	Imputed	T	DOM	431	0.6673	0.206	0.4456	0.9992	−1.964	0.04955
  rs1582322	Imputed	A	DOM	426	0.6832	0.2069	0.4554	1.025	−1.841	0.06568
  rs1582323	Imputed	A	DOM	427	0.6891	0.2068	0.4595	1.034	−1.8	0.07179
  rs1592485	Imputed	C	DOM	430	0.6849	0.2064	0.4571	1.026	−1.834	0.06669
  rs1600954	Imputed	T	ADD	418	1.458	0.1435	1.1	1.931	2.627	0.00863
  rs1600954	Imputed	T	GEN	418					7.629	0.02204
  rs16938626	Imputed	G	DOM	417	0.6482	0.201	0.4371	0.9612	−2.157	0.03103
  rs16964300	Imputed	G	ADD	431	0.6489	0.1758	0.4598	0.9158	−2.461	0.01387
  rs16964300	Imputed	G	DOM	431	0.5081	0.2092	0.3372	0.7656	−3.237	0.00121
  rs16986282	Imputed	G	DOM	429	0.6518	0.4222	0.2849	1.491	−1.014	0.3106
  rs17007620	Imputed	G	ADD	387	1.684	0.1701	1.206	2.35	3.063	0.00219
  rs17007620	Imputed	G	DOM	387	1.898	0.2093	1.259	2.861	3.062	0.0022
  rs17014326	Imputed	G	DOM	429	0.6773	0.1968	0.4605	0.9961	−1.98	0.04771
  rs17047957	Imputed	C	DOM	430	1.575	0.2288	1.006	2.466	1.986	0.047
  rs1705261	Imputed	A	REC	430	1.6	0.2523	0.9755	2.623	1.862	0.06263
  rs17073341	Imputed	A	ADD	431	1.335	0.3929	0.618	2.883	0.735	0.4624
  rs17073341	Imputed	A	DOM	431	1.335	0.3929	0.618	2.883	0.735	0.4624
  rs17138702	Imputed	G	ADD	429	0.7112	0.2144	0.4672	1.083	−1.59	0.1119
  rs17189710	Imputed	T	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs17189710	Imputed	T	GEN	431					6.605	0.0368
  rs17189710	Imputed	T	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs17310176	Imputed	T	ADD	431	0.8153	0.1969	0.5542	1.199	−1.037	0.2997
  rs17310176	Imputed	T	DOM	431	0.8122	0.2102	0.5379	1.226	−0.989	0.3224
  rs17358860	Imputed	A	DOM	431	0.7804	0.2073	0.5199	1.172	−1.196	0.2317
  rs17370541	Imputed	T	GEN	417					4.709	0.09495
  rs17370541	Imputed	T	REC	417	1.782	0.2901	1.009	3.147	1.991	0.04643
  rs17526574	Imputed	G	GEN	431					7.984	0.01846
  rs17530747	Imputed	T	DOM	422	0.7249	0.1996	0.4902	1.072	−1.612	0.107
  rs17649114	Imputed	C	DOM	429	1.27	0.2011	0.8563	1.884	1.189	0.2346
  rs17766172	Imputed	A	REC	419	0.6013	0.3147	0.3245	1.114	−1.616	0.1061
  rs1818885	Imputed	G	GEN	431					7.055	0.02938
  rs1832222	Imputed	G	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs1861327	Imputed	G	DOM	431	0.6673	0.206	0.4456	0.9992	−1.964	0.04955
  rs1868581	Imputed	G	ADD	431	1.471	0.1402	1.117	1.936	2.75	0.00596
  rs1868581	Imputed	G	GEN	431					7.563	0.02279
  rs1874313	Imputed	A	ADD	430	0.671	0.151	0.4991	0.9022	−2.642	0.00825
  rs1874313	Imputed	A	DOM	430	0.5994	0.208	0.3987	0.9009	−2.462	0.01383
  rs1876409	Imputed	C	DOM	428	0.6523	0.1975	0.443	0.9607	−2.163	0.03053
  rs1913201	Imputed	G	ADD	429	0.7714	0.144	0.5817	1.023	−1.803	0.07146
  rs1913201	Imputed	G	DOM	429	0.5986	0.2106	0.3961	0.9045	−2.436	0.01484
  rs1913201	Imputed	G	GEN	429					6.21	0.04484
  rs1916922	Imputed	T	GEN	415					6.677	0.03549
  rs1936871	Genotyped	G	DOM	431	0.7159	0.1987	0.485	1.057	−1.682	0.09248
  rs1961157	Imputed	T	REC	431	0.4785	0.2451	0.296	0.7736	−3.007	0.00264
  rs1987179	Imputed	T	ADD	431	0.7399	0.1691	0.5312	1.031	−1.782	0.07475
  rs1987179	Imputed	T	DOM	431	0.6359	0.2028	0.4273	0.9464	−2.232	0.02564
  rs1990023	Imputed	T	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs1995025	Imputed	C	DOM	431	1.335	0.2271	0.8555	2.084	1.273	0.203
  rs2016194	Imputed	G	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs2023651	Imputed	T	ADD	429	0.5946	0.1842	0.4144	0.8532	−2.822	0.00477
  rs2024902	Imputed	A	ADD	431	1.964	0.3063	1.077	3.579	2.203	0.02757
  rs2024902	Imputed	A	DOM	431	2.136	0.3162	1.15	3.97	2.401	0.01635
  rs2025107	Imputed	A	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs2025108	Imputed	T	DOM	431	2.069	0.3044	1.14	3.758	2.389	0.01687
  rs2031987	Imputed	T	GEN	431					7.984	0.01846
  rs2052428	Imputed	C	DOM	426	0.6505	0.2223	0.4208	1.006	−1.935	0.05303
  rs2053230	Imputed	C	ADD	269	0.6927	0.629	0.2019	2.376	−0.584	0.5594
  rs2062448	Imputed	T	DOM	429	0.5357	0.2593	0.3223	0.8905	−2.407	0.01607
  rs2063420	Imputed	C	REC	430	1.886	0.2499	1.156	3.079	2.54	0.01109
  rs2063591	Imputed	C	ADD	429	0.7822	0.144	0.5899	1.037	−1.705	0.08815
  rs2063591	Imputed	C	DOM	429	0.6108	0.2122	0.403	0.9258	−2.324	0.02015
  rs208026	Genotyped	A	DOM	431	1.516	0.1978	1.029	2.233	2.102	0.03554
  rs208029	Imputed	T	DOM	426	1.45	0.2007	0.9788	2.15	1.853	0.06389
  rs208757	Imputed	G	DOM	425	1.473	0.2014	0.9925	2.186	1.923	0.05453
  rs2095586	Imputed	A	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs2095606	Imputed	A	DOM	424	0.6502	0.2018	0.4378	0.9657	−2.133	0.03293
  rs2102374	Imputed	A	ADD	431	0.7364	0.156	0.5424	0.9998	−1.961	0.04987
  rs2102374	Imputed	A	DOM	431	0.6065	0.198	0.4114	0.894	−2.526	0.01155
  rs2108426	Imputed	C	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs2110664	Imputed	A	DOM	421	1.806	0.2004	1.219	2.675	2.95	0.00318
  rs2132242	Imputed	A	ADD	431	0.6841	0.1503	0.5096	0.9184	−2.527	0.01152
  rs2132242	Imputed	A	DOM	431	0.62	0.207	0.4133	0.9302	−2.31	0.0209
  rs2158958	Imputed	A	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs2158961	Imputed	G	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs2163046	Imputed	A	DOM	430	1.511	0.1971	1.027	2.224	2.095	0.0362
  rs2180286	Imputed	G	DOM	431	0.7195	0.2291	0.4592	1.127	−1.437	0.1507
  rs2180684	Imputed	A	DOM	427	1.612	0.2668	0.9556	2.719	1.79	0.07349
  rs2188079	Imputed	C	ADD	430	1.535	0.1452	1.154	2.04	2.948	0.00319
  rs2188079	Imputed	C	GEN	430					8.853	0.01196
  rs2190598	Imputed	T	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs2190600	Imputed	A	DOM	423	0.6884	0.1986	0.4665	1.016	−1.88	0.0601
  rs2224184	Genotyped	T	DOM	431	0.7175	0.2276	0.4593	1.121	−1.458	0.1447
  rs2247066	Imputed	A	DOM	431	0.6603	0.1967	0.4491	0.9708	−2.11	0.03482
  rs2248236	Imputed	C	ADD	430	0.7444	0.1691	0.5344	1.037	−1.746	0.08088
  rs2248236	Imputed	C	DOM	430	0.6416	0.2031	0.431	0.9552	−2.186	0.02885
  rs2265733	Imputed	C	ADD	431	0.7364	0.156	0.5424	0.9998	−1.961	0.04987
  rs2265733	Imputed	C	DOM	431	0.6065	0.198	0.4114	0.894	−2.526	0.01155
  rs2270584	Imputed	A	ADD	431	0.6858	0.1487	0.5125	0.9178	−2.537	0.01119
  rs2270584	Imputed	A	DOM	431	0.6021	0.2055	0.4025	0.9008	−2.468	0.01358
  rs2270586	Imputed	A	ADD	431	0.6858	0.1487	0.5125	0.9178	−2.537	0.01119
  rs2270586	Imputed	A	DOM	431	0.6021	0.2055	0.4025	0.9008	−2.468	0.01358
  rs229775	Imputed	A	REC	431	0.5915	0.3332	0.3078	1.136	−1.576	0.115
  rs229815	Imputed	T	REC	428	0.5493	0.3402	0.282	1.07	−1.761	0.07822
  rs229829	Imputed	C	REC	431	0.6223	0.2965	0.3481	1.113	−1.6	0.1096
  rs229831	Imputed	A	REC	431	0.646	0.3469	0.3273	1.275	−1.26	0.2077
  rs2317057	Imputed	T	ADD	363	0.7197	0.1827	0.5031	1.029	−1.801	0.07173
  rs2322100	Genotyped	T	REC	431	2.767	0.3609	1.364	5.612	2.82	0.0048
  rs2322101	Imputed	A	REC	429	2.779	0.3611	1.369	5.639	2.83	0.00465
  rs2327929	Imputed	G	REC	431	1.493	0.244	0.9255	2.408	1.642	0.1005
  rs2332844	Imputed	A	ADD	240	1.78	0.4323	0.7629	4.154	1.334	0.1823
  rs2332844	Imputed	A	REC	240	1.78	0.4323	0.7629	4.154	1.334	0.1823
  rs2349170	Imputed	G	DOM	430	1.327	0.204	0.8895	1.979	1.386	0.1657
  rs2356722	Imputed	G	DOM	431	0.6675	0.1966	0.4541	0.9812	−2.057	0.03972
  rs2364956	Imputed	T	ADD	423	1.693	0.1737	1.204	2.379	3.031	0.00244
  rs2373793	Imputed	G	ADD	430	1.58	0.174	1.124	2.223	2.629	0.00855
  rs2373793	Imputed	G	DOM	430	1.878	0.2064	1.253	2.815	3.055	0.00225
  rs238252	Imputed	G	ADD	427	1.531	0.1916	1.052	2.229	2.223	0.02622
  rs238252	Imputed	G	DOM	427	1.593	0.2148	1.046	2.427	2.169	0.03007
  rs2383903	Imputed	G	DOM	430	0.6499	0.1976	0.4413	0.9572	−2.181	0.02915
  rs2387945	Imputed	G	DOM	431	1.335	0.2271	0.8555	2.084	1.273	0.203
  rs2389863	Imputed	A	DOM	426	0.6341	0.2035	0.4255	0.9449	−2.238	0.0252
  rs2389866	Imputed	C	DOM	431	0.6359	0.2028	0.4273	0.9464	−2.232	0.02564
  rs2389869	Imputed	C	DOM	431	0.6359	0.2028	0.4273	0.9464	−2.232	0.02564
  rs2389870	Genotyped	C	DOM	431	0.7988	0.2067	0.5327	1.198	−1.087	0.2772
  rs2418494	Imputed	G	ADD	423	0.7065	0.1402	0.5367	0.93	−2.477	0.01323
  rs2418494	Imputed	G	GEN	423					8.762	0.01252
  rs2418541	Imputed	A	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs2418542	Imputed	A	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs2423556	Imputed	C	DOM	431	0.7195	0.2291	0.4592	1.127	−1.437	0.1507
  rs2437688	Imputed	C	ADD	431	1.486	0.2416	0.9251	2.385	1.638	0.1014
  rs2456809	Imputed	G	DOM	426	0.6547	0.1977	0.4444	0.9645	−2.143	0.03215
  rs2456811	Imputed	T	ADD	431	0.7364	0.156	0.5424	0.9998	−1.961	0.04987
  rs2456811	Imputed	T	DOM	431	0.6065	0.198	0.4114	0.894	−2.526	0.01155
  rs2476976	Imputed	C	DOM	429	1.409	0.1971	0.9578	2.074	1.741	0.08162
  rs2484911	Imputed	A	DOM	431	1.477	0.1971	1.004	2.173	1.979	0.04785
  rs2488557	Imputed	C	DOM	428	0.6282	0.2326	0.3982	0.991	−1.999	0.04561
  rs250162	Imputed	C	ADD	425	0.5822	0.1715	0.416	0.8149	−3.153	0.00162
  rs250162	Imputed	C	DOM	425	0.5055	0.2024	0.3399	0.7517	−3.37	0.00075
  rs2560708	Imputed	T	ADD	427	0.5918	0.2008	0.3992	0.8772	−2.612	0.00899
  rs2617841	Imputed	G	DOM	397	0.5505	0.2134	0.3623	0.8365	−2.797	0.00516
  rs2622499	Imputed	G	DOM	431	0.6359	0.2028	0.4273	0.9464	−2.232	0.02564
  rs264129	Imputed	T	DOM	414	0.7088	0.2008	0.4781	1.051	−1.714	0.08655
  rs2642936	Imputed	T	ADD	427	1.703	0.1807	1.195	2.427	2.947	0.00321
  rs2660633	Imputed	A	DOM	428	0.6523	0.1975	0.443	0.9607	−2.163	0.03053
  rs2660634	Imputed	C	DOM	428	0.6523	0.1975	0.443	0.9607	−2.163	0.03053
  rs2660648	Imputed	A	ADD	431	0.7364	0.156	0.5424	0.9998	−1.961	0.04987
  rs2660648	Imputed	A	DOM	431	0.6065	0.198	0.4114	0.894	−2.526	0.01155
  rs2681505	Imputed	T	ADD	431	0.6724	0.1684	0.4834	0.9355	−2.356	0.01848
  rs277411	Imputed	G	DOM	430	0.2825	0.5064	0.1047	0.7621	−2.496	0.01254
  rs2832634	Imputed	G	ADD	430	2.272	0.3513	1.141	4.523	2.335	0.01952
  rs2832637	Imputed	T	ADD	430	2.272	0.3513	1.141	4.523	2.335	0.01952
  rs2843167	Imputed	A	DOM	430	0.6655	0.1968	0.4525	0.9788	−2.069	0.03855
  rs2876227	Imputed	C	ADD	420	1.382	0.142	1.046	1.825	2.277	0.02278
  rs2876227	Imputed	C	GEN	420					5.885	0.05274
  rs2882097	Imputed	A	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs2909862	Imputed	G	DOM	381	1.471	0.2415	0.9162	2.361	1.597	0.1102
  rs3001945	Imputed	T	DOM	408	1.39	0.2492	0.8531	2.266	1.323	0.186
  rs3011020	Imputed	C	DOM	431	1.335	0.2271	0.8555	2.084	1.273	0.203
  rs36071725	Genotyped	C	ADD	431	1.458	0.1473	1.093	1.946	2.562	0.01039
  rs36071725	Genotyped	C	GEN	431					7.178	0.02762
  rs373983	Imputed	G	DOM	424	1.332	0.2094	0.8836	2.008	1.369	0.171
  rs3743794	Imputed	G	DOM	426	0.6969	0.2073	0.4642	1.046	−1.742	0.08148
  rs3756154	Imputed	C	ADD	431	0.7399	0.1691	0.5312	1.031	−1.782	0.07475
  rs3756154	Imputed	C	DOM	431	0.6359	0.2028	0.4273	0.9464	−2.232	0.02564
  rs3775850	Imputed	A	DOM	431	0.7804	0.2073	0.5199	1.172	−1.196	0.2317
  rs3775851	Imputed	C	DOM	431	0.7804	0.2073	0.5199	1.172	−1.196	0.2317
  rs3793044	Imputed	C	ADD	431	1.892	0.308	1.035	3.461	2.071	0.0384
  rs3793044	Imputed	C	DOM	431	2.057	0.3182	1.102	3.838	2.266	0.02342
  rs3793053	Imputed	C	DOM	425	2.254	0.3145	1.217	4.175	2.583	0.00979
  rs3796246	Imputed	G	DOM	431	0.4542	0.2717	0.2667	0.7737	−2.904	0.00368
  rs3806003	Imputed	A	ADD	431	1.892	0.308	1.035	3.461	2.071	0.0384
  rs3806003	Imputed	A	DOM	431	2.057	0.3182	1.102	3.838	2.266	0.02342
  rs3806004	Imputed	T	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs3806010	Imputed	T	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs3806014	Imputed	T	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs3806015	Imputed	A	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs3806018	Imputed	A	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs3806019	Imputed	A	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs3806024	Imputed	T	DOM	425	2.254	0.3145	1.217	4.175	2.583	0.00979
  rs3915080	Imputed	A	GEN	426					6.343	0.04195
  rs3942254	Imputed	T	ADD	423	0.6915	0.1524	0.513	0.9322	−2.421	0.01549
  rs3942254	Imputed	T	DOM	423	0.6256	0.2108	0.4139	0.9456	−2.225	0.02605
  rs3945085	Imputed	A	DOM	431	1.52	0.1971	1.033	2.237	2.125	0.03357
  rs3976737	Imputed	G	ADD	430	0.6593	0.2103	0.4366	0.9956	−1.981	0.0476
  rs399485	Imputed	A	DOM	431	1.467	0.1973	0.9965	2.159	1.942	0.05212
  rs4029119	Imputed	G	ADD	429	0.361	0.577	0.1165	1.118	−1.766	0.0774
  rs4029119	Imputed	G	DOM	429	0.361	0.577	0.1165	1.118	−1.766	0.0774
  rs4076201	Imputed	G	GEN	430					6.108	0.04718
  rs4076201	Imputed	G	REC	430	2.964	0.4471	1.234	7.119	2.43	0.01509
  rs41395945	Imputed	G	ADD	430	2.272	0.3513	1.141	4.523	2.335	0.01952
  rs41395945	Imputed	G	DOM	430	2.245	0.362	1.104	4.564	2.234	0.02549
  rs4146972	Genotyped	T	DOM	431	1.557	0.2271	0.9976	2.43	1.949	0.05125
  rs4238087	Imputed	G	DOM	425	0.5314	0.2341	0.3358	0.8408	−2.7	0.00692
  rs4251569	Imputed	T	ADD	425	0.5471	0.2243	0.3525	0.8491	−2.689	0.00716
  rs4251569	Imputed	T	DOM	425	0.5314	0.2341	0.3358	0.8408	−2.7	0.00692
  rs4273613	Imputed	T	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs4273613	Imputed	T	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs4291049	Imputed	T	REC	428	0.5862	0.2628	0.3502	0.9812	−2.032	0.04213
  rs4315598	Imputed	T	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs4315598	Imputed	T	GEN	431					6.605	0.0368
  rs4315598	Imputed	T	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs4321395	Imputed	A	DOM	400	0.5278	0.2223	0.3414	0.816	−2.875	0.00404
  rs4321596	Genotyped	T	REC	431	3.01	0.5138	1.099	8.238	2.145	0.03199
  rs4324417	Imputed	T	DOM	431	1.541	0.2104	1.02	2.328	2.055	0.03989
  rs4328619	Genotyped	G	DOM	431	0.6446	0.2226	0.4167	0.9973	−1.972	0.04857
  rs4338909	Imputed	T	ADD	431	1.42	0.1425	1.074	1.878	2.462	0.01381
  rs4370878	Imputed	G	DOM	431	1.497	0.197	1.017	2.202	2.046	0.04075
  rs4379434	Genotyped	T	DOM	431	1.603	0.203	1.077	2.386	2.323	0.02015
  rs4416407	Imputed	T	DOM	429	1.502	0.2225	0.9712	2.324	1.829	0.06743
  rs4417899	Imputed	C	REC	429	0.6657	0.2225	0.4304	1.03	−1.829	0.06743
  rs4442732	Imputed	A	ADD	335	0.7543	0.1867	0.5231	1.088	−1.511	0.1309
  rs4444612	Imputed	G	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs4444612	Imputed	G	GEN	431					6.605	0.0368
  rs4444612	Imputed	G	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs4450660	Imputed	C	DOM	430	1.776	0.2015	1.196	2.636	2.849	0.00438
  rs4509702	Imputed	C	DOM	431	1.497	0.197	1.017	2.202	2.046	0.04075
  rs4526920	Imputed	G	GEN	431					7.984	0.01846
  rs4533145	Imputed	T	DOM	430	0.6617	0.2453	0.4092	1.07	−1.683	0.09231
  rs4557006	Imputed	A	DOM	395	0.5409	0.225	0.348	0.8407	−2.731	0.00631
  rs4570530	Imputed	C	DOM	431	1.497	0.197	1.017	2.202	2.046	0.04075
  rs4615971	Imputed	C	DOM	429	1.474	0.1973	1.001	2.17	1.965	0.04937
  rs4628119	Imputed	A	DOM	431	0.5304	0.202	0.357	0.7881	−3.139	0.0017
  rs4664443	Imputed	G	ADD	431	0.6931	0.1457	0.521	0.9221	−2.517	0.01184
  rs4688259	Imputed	T	DOM	429	1.502	0.2225	0.9712	2.324	1.829	0.06743
  rs4688632	Imputed	G	REC	426	0.6718	0.2217	0.435	1.038	−1.794	0.07285
  rs4695284	Imputed	A	ADD	231	1.566	0.2722	0.9182	2.669	1.647	0.09965
  rs4700302	Imputed	A	ADD	368	0.5418	0.2966	0.303	0.9689	−2.067	0.03877
  rs4702720	Imputed	A	ADD	363	0.7075	0.1961	0.4817	1.039	−1.765	0.07759
  rs4702720	Imputed	A	DOM	363	0.7149	0.2239	0.461	1.109	−1.499	0.1339
  rs4711091	Genotyped	G	GEN	431					3.583	0.1667
  rs4714484	Imputed	A	ADD	431	0.5609	0.1882	0.3879	0.8112	−3.071	0.00213
  rs4736802	Imputed	G	DOM	430	1.614	0.2031	1.084	2.404	2.357	0.01841
  rs4760785	Imputed	A	ADD	429	0.7714	0.144	0.5817	1.023	−1.803	0.07146
  rs4760785	Imputed	A	DOM	429	0.5986	0.2106	0.3961	0.9045	−2.436	0.01484
  rs4760785	Imputed	A	GEN	429					6.21	0.04484
  rs4760894	Imputed	T	ADD	429	0.7714	0.144	0.5817	1.023	−1.803	0.07146
  rs4760894	Imputed	T	DOM	429	0.5986	0.2106	0.3961	0.9045	−2.436	0.01484
  rs4760894	Imputed	T	GEN	429					6.21	0.04484
  rs4760895	Imputed	A	ADD	429	0.7714	0.144	0.5817	1.023	−1.803	0.07146
  rs4760895	Imputed	A	DOM	429	0.5986	0.2106	0.3961	0.9045	−2.436	0.01484
  rs4760895	Imputed	A	GEN	429					6.21	0.04484
  rs4764738	Imputed	A	ADD	425	1.555	0.1426	1.176	2.056	3.095	0.00197
  rs4764738	Imputed	A	GEN	425					9.814	0.00739
  rs4764974	Imputed	T	ADD	430	1.512	0.1414	1.146	1.995	2.923	0.00347
  rs4764974	Imputed	T	GEN	430					8.948	0.0114
  rs4798366	Imputed	G	REC	426	2.304	0.315	1.243	4.271	2.65	0.00806
  rs483159	Imputed	T	DOM	418	1.412	0.2046	0.9455	2.108	1.686	0.09181
  rs4836502	Imputed	T	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs4836507	Imputed	C	DOM	423	0.6884	0.1986	0.4665	1.016	−1.88	0.0601
  rs4836744	Imputed	A	ADD	429	0.7704	0.1539	0.5698	1.042	−1.694	0.09021
  rs4836744	Imputed	A	DOM	429	0.6637	0.1983	0.4499	0.979	−2.067	0.03872
  rs4848944	Genotyped	C	REC	431	0.464	0.245	0.287	0.75	−3.134	0.00172
  rs4851529	Imputed	A	DOM	431	0.5663	0.2029	0.3805	0.8429	−2.802	0.00507
  rs4851531	Imputed	T	DOM	430	0.5588	0.2033	0.3751	0.8325	−2.862	0.00421
  rs4858046	Genotyped	T	GEN	431					6.792	0.0335
  rs4878214	Imputed	A	ADD	343	0.7413	0.1824	0.5185	1.06	−1.641	0.1007
  rs4880803	Imputed	A	ADD	421	0.7588	0.1519	0.5634	1.022	−1.818	0.06914
  rs489441	Imputed	G	ADD	408	1.6	0.1627	1.163	2.2	2.888	0.00387
  rs489441	Imputed	G	DOM	408	1.651	0.2035	1.108	2.46	2.463	0.01378
  rs4896568	Imputed	T	DOM	430	0.5426	0.2032	0.3643	0.8081	−3.008	0.00263
  rs4938851	Imputed	T	DOM	431	1.301	0.2004	0.8785	1.927	1.313	0.1891
  rs4964416	Imputed	C	DOM	428	0.6799	0.2267	0.436	1.06	−1.702	0.08872
  rs5756669	Imputed	C	DOM	431	1.541	0.2104	1.02	2.328	2.055	0.03989
  rs6033138	Imputed	C	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs6033138	Imputed	C	GEN	431					6.605	0.0368
  rs6033138	Imputed	C	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs6040619	Imputed	C	ADD	427	1.488	0.1435	1.123	1.972	2.771	0.00559
  rs6040619	Imputed	C	GEN	427					7.811	0.02013
  rs6040619	Imputed	C	REC	427	1.688	0.2858	0.964	2.956	1.832	0.06702
  rs6040625	Imputed	T	ADD	425	1.479	0.1442	1.115	1.962	2.714	0.00665
  rs6040625	Imputed	T	GEN	425					7.591	0.02248
  rs6040625	Imputed	T	REC	425	1.634	0.2879	0.9294	2.873	1.706	0.08806
  rs6040630	Imputed	A	ADD	431	1.42	0.1417	1.076	1.875	2.476	0.01327
  rs6040630	Imputed	A	GEN	431					6.71	0.03491
  rs6040630	Imputed	A	REC	431	1.462	0.2807	0.8433	2.534	1.353	0.1762
  rs6040633	Imputed	A	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs6040633	Imputed	A	GEN	431					6.605	0.0368
  rs6040633	Imputed	A	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs6040634	Imputed	T	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs6040634	Imputed	T	GEN	431					6.605	0.0368
  rs6040634	Imputed	T	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs6040636	Imputed	T	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs6040636	Imputed	T	GEN	431					6.605	0.0368
  rs6040636	Imputed	T	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs6040638	Imputed	C	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs6040638	Imputed	C	GEN	431					6.605	0.0368
  rs6040638	Imputed	C	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs6040644	Imputed	A	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs6040644	Imputed	A	GEN	431					6.605	0.0368
  rs6040644	Imputed	A	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs6040667	Imputed	T	ADD	427	1.391	0.1412	1.055	1.835	2.338	0.0194
  rs6040667	Imputed	T	GEN	427					6.078	0.04788
  rs6040667	Imputed	T	REC	427	1.416	0.2791	0.8195	2.447	1.247	0.2125
  rs6040668	Imputed	C	ADD	422	1.386	0.1419	1.049	1.83	2.3	0.02147
  rs6040668	Imputed	C	GEN	422					5.936	0.05141
  rs6040668	Imputed	C	REC	422	1.401	0.2794	0.8101	2.422	1.206	0.2277
  rs6043066	Genotyped	G	DOM	431	1.208	0.1979	0.8196	1.781	0.955	0.3397
  rs6048146	Imputed	G	DOM	431	3.484	0.6015	1.072	11.33	2.075	0.03796
  rs6082725	Genotyped	T	DOM	431	3.484	0.6015	1.072	11.33	2.075	0.03796
  rs6131206	Imputed	C	ADD	429	1.424	0.1456	1.07	1.894	2.425	0.01529
  rs6131208	Imputed	T	ADD	429	1.398	0.1412	1.06	1.843	2.371	0.01776
  rs6131208	Imputed	T	GEN	429					6.201	0.04504
  rs6131208	Imputed	T	REC	429	1.431	0.2791	0.828	2.472	1.284	0.1993
  rs6134243	Imputed	C	ADD	431	1.407	0.1412	1.067	1.855	2.418	0.01561
  rs6134243	Imputed	C	GEN	431					6.605	0.0368
  rs6134243	Imputed	C	REC	431	1.414	0.279	0.8186	2.444	1.243	0.214
  rs6136020	Imputed	A	DOM	431	0.7169	0.227	0.4595	1.119	−1.466	0.1426
  rs613799	Imputed	C	DOM	414	1.45	0.2012	0.9772	2.15	1.845	0.06502
  rs644041	Imputed	G	ADD	401	1.555	0.164	1.127	2.144	2.69	0.00715
  rs644041	Imputed	G	DOM	401	1.611	0.2049	1.078	2.407	2.327	0.01999
  rs647645	Imputed	C	ADD	430	0.7227	0.1429	0.5462	0.9563	−2.273	0.02304
  rs647645	Imputed	C	GEN	430					8.278	0.01594
  rs647645	Imputed	C	REC	430	0.4895	0.2484	0.3008	0.7965	−2.876	0.00403
  rs6495554	Imputed	C	GEN	431					6.084	0.04773
  rs6495554	Imputed	C	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs6495555	Imputed	C	GEN	431					6.084	0.04773
  rs6495555	Imputed	C	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs6544728	Imputed	T	DOM	429	1.888	0.2031	1.268	2.811	3.128	0.00176
  rs6550705	Imputed	C	ADD	430	1.45	0.1393	1.104	1.906	2.67	0.00759
  rs6550705	Imputed	C	GEN	430					7.13	0.0283
  rs6550707	Imputed	T	GEN	430					6.869	0.03224
  rs658108	Imputed	A	DOM	431	1.477	0.1971	1.004	2.173	1.979	0.04785
  rs6593441	Imputed	A	DOM	404	1.885	0.2414	1.175	3.026	2.627	0.00862
  rs668732	Imputed	A	DOM	431	1.56	0.2218	1.01	2.409	2.004	0.04506
  rs671041	Imputed	A	DOM	431	1.507	0.1971	1.024	2.217	2.08	0.03752
  rs6719700	Imputed	A	ADD	412	1.583	0.1792	1.114	2.249	2.562	0.0104
  rs6719700	Imputed	A	DOM	412	1.517	0.2015	1.022	2.252	2.07	0.03845
  rs6722640	Imputed	T	DOM	431	0.5555	0.2033	0.373	0.8273	−2.892	0.00382
  rs6743092	Imputed	T	ADD	431	1.365	0.1398	1.038	1.796	2.226	0.02603
  rs6743092	Imputed	T	GEN	431					4.984	0.08273
  rs6743092	Imputed	T	REC	431	1.555	0.2336	0.9841	2.458	1.891	0.05858
  rs6744759	Imputed	G	REC	424	1.89	0.3377	0.9751	3.664	1.885	0.0594
  rs6746170	Imputed	A	DOM	425	1.805	0.2035	1.211	2.69	2.901	0.00372
  rs6759922	Imputed	A	DOM	399	0.537	0.2229	0.3469	0.8311	−2.79	0.00527
  rs6769864	Imputed	T	GEN	431					7.055	0.02938
  rs6773932	Imputed	C	GEN	426					5.96	0.05078
  rs6774353	Imputed	A	GEN	431					7.055	0.02938
  rs6781670	Imputed	C	GEN	431					7.563	0.02279
  rs6786431	Imputed	A	GEN	426					5.96	0.05078
  rs6789091	Imputed	T	GEN	426					5.96	0.05078
  rs6791296	Imputed	T	ADD	414	0.6404	0.2337	0.4051	1.012	−1.907	0.05647
  rs6792662	Imputed	G	DOM	429	1.502	0.2225	0.9712	2.324	1.829	0.06743
  rs6797574	Imputed	G	GEN	426					5.96	0.05078
  rs6797882	Imputed	G	GEN	426					5.96	0.05078
  rs6805139	Imputed	G	DOM	428	1.519	0.2225	0.9819	2.348	1.878	0.06041
  rs6806043	Imputed	C	ADD	430	1.47	0.1394	1.118	1.931	2.761	0.00577
  rs6806043	Imputed	C	GEN	430					7.621	0.02214
  rs6850716	Imputed	C	GEN	431					4.671	0.09677
  rs6867153	Imputed	A	REC	428	0.5862	0.2628	0.3502	0.9812	−2.032	0.04213
  rs687047	Imputed	C	ADD	431	0.7129	0.2248	0.4589	1.107	−1.506	0.1321
  rs6871041	Imputed	G	DOM	425	0.6929	0.1978	0.4702	1.021	−1.855	0.06367
  rs688358	Imputed	A	ADD	427	0.6788	0.2285	0.4338	1.062	−1.695	0.08999
  rs6888012	Imputed	A	REC	428	0.5862	0.2628	0.3502	0.9812	−2.032	0.04213
  rs6908481	Imputed	C	REC	428	1.658	0.2609	0.9942	2.764	1.938	0.05267
  rs7032231	Imputed	A	ADD	429	1.467	0.1469	1.1	1.957	2.609	0.00908
  rs7067638	Imputed	T	DOM	431	1.82	0.2397	1.138	2.911	2.498	0.01249
  rs7077799	Imputed	A	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs7082163	Imputed	A	ADD	430	1.817	0.2063	1.213	2.722	2.895	0.0038
  rs7082163	Imputed	A	DOM	430	1.875	0.239	1.173	2.995	2.629	0.00856
  rs7089661	Imputed	C	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs7101319	Imputed	C	ADD	430	1.817	0.2063	1.213	2.722	2.895	0.0038
  rs7101319	Imputed	C	DOM	430	1.875	0.239	1.173	2.995	2.629	0.00856
  rs710832	Genotyped	A	GEN	431					6.307	0.0427
  rs710832	Genotyped	A	REC	431	0.256	0.5608	0.0853	0.7684	−2.43	0.01511
  rs7134262	Imputed	T	GEN	418					3.095	0.2128
  rs7134262	Imputed	T	REC	418	1.627	0.2899	0.9217	2.871	1.679	0.09319
  rs7134671	Imputed	T	GEN	428					10.66	0.00484
  rs7138300	Imputed	C	ADD	429	0.7714	0.144	0.5817	1.023	−1.803	0.07146
  rs7138300	Imputed	C	DOM	429	0.5986	0.2106	0.3961	0.9045	−2.436	0.01484
  rs7138300	Imputed	C	GEN	429					6.21	0.04484
  rs7163931	Imputed	G	GEN	431					6.084	0.04773
  rs7163931	Imputed	G	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs7171486	Genotyped	G	DOM	431	0.5774	0.203	0.3878	0.8595	−2.706	0.00681
  rs7172611	Imputed	G	GEN	431					6.084	0.04773
  rs7172611	Imputed	G	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs7172689	Imputed	T	GEN	431					6.084	0.04773
  rs7172689	Imputed	T	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs7175701	Imputed	C	GEN	431					6.07	0.04808
  rs7180245	Imputed	A	GEN	431					6.084	0.04773
  rs7180245	Imputed	A	REC	431	3.183	0.4709	1.265	8.011	2.459	0.01395
  rs7220603	Genotyped	A	ADD	431	0.6302	0.1616	0.4591	0.865	−2.857	0.00428
  rs7282518	Imputed	T	ADD	375	1.518	0.1836	1.06	2.176	2.275	0.02291
  rs7283476	Imputed	T	ADD	429	0.6337	0.4061	0.2859	1.405	−1.123	0.2614
  rs7283476	Imputed	T	DOM	429	0.6518	0.4222	0.2849	1.491	−1.014	0.3106
  rs7295817	Imputed	C	GEN	427					1.689	0.4298
  rs7298255	Imputed	A	ADD	430	0.7591	0.1447	0.5717	1.008	−1.905	0.05677
  rs7298255	Imputed	A	DOM	430	0.594	0.2105	0.3932	0.8973	−2.475	0.01332
  rs7305832	Imputed	C	GEN	431					3.043	0.2184
  rs7305832	Imputed	C	REC	431	1.616	0.2891	0.9169	2.847	1.66	0.09694
  rs7331467	Imputed	A	GEN	431					11.32	0.00349
  rs7392620	Imputed	C	ADD	421	0.7494	0.1521	0.5562	1.01	−1.896	0.05801
  rs742827	Imputed	A	ADD	423	1.374	0.1417	1.041	1.814	2.245	0.02479
  rs742827	Imputed	A	GEN	423					5.635	0.05977
  rs742827	Imputed	A	REC	423	1.393	0.2794	0.8055	2.408	1.186	0.2357
  rs7446891	Imputed	G	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs7448641	Imputed	C	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs7448641	Imputed	C	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs7484728	Imputed	T	GEN	429					10.78	0.00456
  rs7499402	Genotyped	A	ADD	431	1.39	0.2523	0.8476	2.279	1.305	0.1919
  rs7529851	Imputed	A	ADD	412	0.6637	0.1466	0.498	0.8846	−2.796	0.00517
  rs7529851	Imputed	A	GEN	412					7.96	0.01868
  rs7573951	Imputed	G	ADD	431	0.6931	0.1457	0.521	0.9221	−2.517	0.01184
  rs7599198	Imputed	T	DOM	373	0.5474	0.2267	0.351	0.8537	−2.658	0.00787
  rs7600050	Imputed	C	ADD	408	1.511	0.1483	1.13	2.02	2.782	0.00541
  rs7607712	Imputed	T	ADD	416	1.551	0.1747	1.101	2.185	2.513	0.01197
  rs7607712	Imputed	T	DOM	416	1.544	0.2007	1.042	2.289	2.165	0.03037
  rs7613492	Imputed	G	GEN	430					7.139	0.02817
  rs7621663	Imputed	G	ADD	431	1.447	0.1393	1.102	1.901	2.655	0.00794
  rs7621663	Imputed	G	GEN	431					7.055	0.02938
  rs7621663	Imputed	G	REC	431	1.785	0.2775	1.036	3.075	2.089	0.03675
  rs7626584	Imputed	G	ADD	431	0.5782	0.3624	0.2842	1.176	−1.511	0.1307
  rs7684899	Imputed	C	ADD	431	0.7399	0.1691	0.5312	1.031	−1.782	0.07475
  rs7684899	Imputed	C	DOM	431	0.6359	0.2028	0.4273	0.9464	−2.232	0.02564
  rs7701604	Imputed	G	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs7701604	Imputed	G	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs7703676	Imputed	C	ADD	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs7703676	Imputed	C	DOM	431	0.309	0.5694	0.1012	0.9434	−2.062	0.03918
  rs7708491	Imputed	C	REC	428	0.5862	0.2628	0.3502	0.9812	−2.032	0.04213
  rs7711358	Imputed	A	DOM	431	0.7035	0.1964	0.4787	1.034	−1.791	0.07336
  rs7719448	Imputed	G	REC	429	0.5823	0.2627	0.348	0.9745	−2.058	0.03958
  rs7724761	Imputed	T	REC	418	0.5608	0.2705	0.3301	0.953	−2.138	0.03252
  rs7742476	Imputed	T	DOM	420	1.408	0.2046	0.9428	2.103	1.672	0.09449
  rs7762993	Imputed	A	ADD	431	1.384	0.1852	0.963	1.99	1.756	0.07907
  rs7762993	Imputed	A	DOM	431	1.506	0.206	1.006	2.255	1.987	0.04689
  rs7767265	Imputed	G	ADD	423	1.375	0.168	0.9889	1.91	1.894	0.05828
  rs7767265	Imputed	G	DOM	423	1.584	0.2032	1.064	2.359	2.263	0.02363
  rs7768128	Imputed	G	REC	407	0.4807	0.4606	0.1949	1.186	−1.59	0.1118
  rs7771264	Imputed	T	DOM	431	0.5289	0.2031	0.3552	0.7874	−3.137	0.00171
  rs7773151	Genotyped	C	DOM	431	0.5304	0.202	0.357	0.7881	−3.139	0.0017
  rs7773210	Genotyped	A	DOM	431	0.5304	0.202	0.357	0.7881	−3.139	0.0017
  rs7808536	Imputed	G	DOM	429	1.939	0.2082	1.289	2.916	3.18	0.00147
  rs7843510	Genotyped	G	DOM	431	1.603	0.203	1.077	2.386	2.323	0.02015
  rs7894867	Imputed	T	DOM	430	1.833	0.2398	1.146	2.932	2.527	0.01151
  rs7921834	Imputed	C	DOM	430	1.458	0.197	0.9908	2.145	1.913	0.05576
  rs7939893	Imputed	C	ADD	431	0.8337	0.1482	0.6235	1.115	−1.227	0.22
  rs7939893	Imputed	C	DOM	431	0.7294	0.1979	0.4949	1.075	−1.594	0.1109
  rs7944513	Imputed	T	GEN	410					5.096	0.07823
  rs7944513	Imputed	T	REC	410	2.257	0.4179	0.9952	5.12	1.949	0.05135
  rs7949720	Imputed	G	ADD	406	0.6348	0.2219	0.4109	0.9807	−2.048	0.0406
  rs7949720	Imputed	G	DOM	406	0.6285	0.2538	0.3822	1.034	−1.83	0.06728
  rs7955901	Imputed	C	ADD	429	0.7576	0.1448	0.5705	1.006	−1.918	0.05515
  rs7955901	Imputed	C	DOM	429	0.5886	0.2107	0.3895	0.8896	−2.516	0.01189
  rs7956274	Imputed	T	ADD	429	0.7688	0.1449	0.5788	1.021	−1.815	0.06949
  rs7956274	Imputed	T	DOM	429	0.6074	0.2105	0.402	0.9176	−2.369	0.01786
  rs7956274	Imputed	T	GEN	429					5.764	0.05601
  rs7957932	Imputed	G	ADD	429	0.7693	0.1441	0.58	1.02	−1.819	0.06884
  rs7957932	Imputed	G	DOM	429	0.5936	0.2123	0.3915	0.8999	−2.457	0.01402
  rs7984504	Imputed	C	GEN	431					7.984	0.01846
  rs7999518	Imputed	A	REC	385	0.6295	0.2746	0.3675	1.078	−1.686	0.09185
  rs8026245	Imputed	G	GEN	431					6.07	0.04808
  rs8026245	Imputed	G	REC	431	2.977	0.4471	1.239	7.15	2.44	0.01469
  rs8060725	Genotyped	A	ADD	431	0.7775	0.173	0.5539	1.091	−1.455	0.1456
  rs8103016	Genotyped	A	ADD	431	1.589	0.1785	1.12	2.254	2.594	0.0095
  rs8103016	Genotyped	A	DOM	431	1.683	0.2037	1.129	2.508	2.555	0.01061
  rs8104182	Imputed	G	ADD	431	1.613	0.1788	1.136	2.289	2.672	0.00754
  rs8104182	Imputed	G	DOM	431	1.716	0.204	1.151	2.56	2.648	0.00811
  rs8129461	Imputed	G	ADD	429	0.6337	0.4061	0.2859	1.405	−1.123	0.2614
  rs8129461	Imputed	G	DOM	429	0.6518	0.4222	0.2849	1.491	−1.014	0.3106
  rs8130021	Imputed	G	ADD	429	0.6337	0.4061	0.2859	1.405	−1.123	0.2614
  rs8130021	Imputed	G	DOM	429	0.6518	0.4222	0.2849	1.491	−1.014	0.3106
  rs879961	Imputed	T	ADD	430	0.7316	0.1563	0.5386	0.9938	−2	0.04552
  rs879961	Imputed	T	DOM	430	0.5986	0.1985	0.4057	0.8831	−2.586	0.00971
  rs906353	Imputed	A	DOM	431	0.6603	0.1967	0.4491	0.9708	−2.11	0.03482
  rs915491	Imputed	C	DOM	431	1.452	0.1969	0.9867	2.135	1.892	0.0585
  rs915493	Imputed	T	DOM	431	1.452	0.1969	0.9867	2.135	1.892	0.0585
  rs915494	Imputed	A	ADD	392	1.279	0.1636	0.9278	1.762	1.502	0.1331
  rs915494	Imputed	A	DOM	392	1.409	0.207	0.9389	2.114	1.656	0.0978
  rs917295	Imputed	G	DOM	429	0.6749	0.197	0.4587	0.993	−1.996	0.04596
  rs9284851	Imputed	A	GEN	426					6.343	0.04195
  rs9293464	Imputed	T	REC	429	0.5823	0.2627	0.348	0.9745	−2.058	0.03958
  rs9295154	Genotyped	G	DOM	431	1.917	0.2188	1.249	2.943	2.974	0.00294
  rs9310221	Imputed	A	DOM	389	1.407	0.2186	0.917	2.16	1.563	0.118
  rs9310699	Genotyped	T	GEN	431					7.563	0.02279
  rs9310700	Imputed	C	ADD	431	1.447	0.1393	1.102	1.901	2.655	0.00794
  rs9310700	Imputed	C	GEN	431					7.055	0.02938
  rs9310701	Imputed	G	GEN	430					6.869	0.03224
  rs9310704	Imputed	G	GEN	426					6.343	0.04195
  rs9319185	Imputed	C	GEN	431					7.984	0.01846
  rs9319186	Imputed	T	GEN	431					7.984	0.01846
  rs9327555	Imputed	T	DOM	429	0.6887	0.197	0.4682	1.013	−1.893	0.05831
  rs9403367	Imputed	C	DOM	431	0.5304	0.202	0.357	0.7881	−3.139	0.0017
  rs9419608	Imputed	G	REC	427	1.589	0.2251	1.022	2.47	2.059	0.03954
  rs9426437	Imputed	T	DOM	426	0.6833	0.203	0.459	1.017	−1.876	0.06061
  rs9454967	Imputed	G	DOM	431	2.24	0.3143	1.21	4.147	2.566	0.0103
  rs9635511	Imputed	T	DOM	427	0.7034	0.2071	0.4687	1.055	−1.699	0.08928
  rs966583	Imputed	A	ADD	431	0.6846	0.1496	0.5106	0.9178	−2.533	0.01131
  rs966583	Imputed	A	DOM	431	0.6092	0.2075	0.4056	0.915	−2.388	0.01694
  rs980263	Imputed	T	GEN	431					6.792	0.0335
  rs980264	Imputed	T	GEN	431					6.792	0.0335
  rs9812206	Imputed	G	ADD	431	0.4853	0.2571	0.2932	0.8033	−2.812	0.00493
  rs9812206	Imputed	G	DOM	431	0.4903	0.2646	0.2919	0.8236	−2.693	0.00707
  rs9813552	Imputed	G	ADD	431	0.5098	0.2537	0.3101	0.8382	−2.656	0.00792
  rs9813552	Imputed	G	DOM	431	0.5166	0.2615	0.3095	0.8625	−2.526	0.01154
  rs9815037	Imputed	T	ADD	430	0.4609	0.2606	0.2765	0.7681	−2.972	0.00296
  rs9815037	Imputed	T	DOM	430	0.4643	0.2679	0.2746	0.7848	−2.864	0.00418
  rs9819583	Imputed	T	GEN	431					7.563	0.02279
  rs9825349	Imputed	A	ADD	431	0.4629	0.2606	0.2778	0.7715	−2.955	0.00312
  rs9825349	Imputed	A	DOM	431	0.4664	0.2679	0.2759	0.7884	−2.847	0.00441
  rs9833118	Imputed	G	ADD	419	1.479	0.1411	1.122	1.95	2.774	0.00554
  rs9833118	Imputed	G	GEN	419					7.693	0.02135
  rs9834217	Imputed	T	ADD	430	0.4658	0.2606	0.2795	0.7764	−2.931	0.00338
  rs9834217	Imputed	T	DOM	430	0.4695	0.2679	0.2777	0.7937	−2.822	0.00477
  rs9838563	Imputed	C	GEN	430					6.869	0.03224
  rs9840460	Imputed	T	ADD	431	0.4629	0.2606	0.2778	0.7715	−2.955	0.00312
  rs9840460	Imputed	T	DOM	431	0.4664	0.2679	0.2759	0.7884	−2.847	0.00441
  rs9840756	Imputed	A	ADD	431	0.4629	0.2606	0.2778	0.7715	−2.955	0.00312
  rs9840756	Imputed	A	DOM	431	0.4664	0.2679	0.2759	0.7884	−2.847	0.00441
  rs9847999	Imputed	C	GEN	426					6.343	0.04195
  rs9864769	Imputed	C	GEN	431					6.792	0.0335
  rs9866421	Genotyped	C	REC	431	0.6994	0.2578	0.4219	1.159	−1.387	0.1655
  rs987296	Imputed	T	GEN	430					7.666	0.02164
  rs9881685	Imputed	A	ADD	431	0.4853	0.2571	0.2932	0.8033	−2.812	0.00493
  rs9881685	Imputed	A	DOM	431	0.4903	0.2646	0.2919	0.8236	−2.693	0.00707
  rs992695	Imputed	C	ADD	431	0.7364	0.156	0.5424	0.9998	−1.961	0.04987
  rs992695	Imputed	C	DOM	431	0.6065	0.198	0.4114	0.894	−2.526	0.01155
  rs9936999	Imputed	G	DOM	249	1.779	0.2695	1.049	3.017	2.137	0.03256
  					PRAVA_			PLACEBO_		PLACEBO_
  			PRAVA_	PLACEBO_	A1_	PRAVA_	PRAVA_	A1_	PLACEBO_	A2_
  	HW_	ALLELE_	ALLELE_	ALLELE_	HZ_	HET_	A2_HZ	HZ_	HET_	HZ_
  SNP rs #	PVALUE	FREQ	FREQ	FREQ	COUNT	COUNT	COUNT	COUNT	COUNT	COUNT
  rs77638540	0.407	0.0348	0.02717	0.04049	0	10	174	1	18	228
  rs72746987	0.01335	0.03596	0.02174	0.04656	2	4	178	1	21	225
  rs10021016	0.8982	0.25174	0.28533	0.22672	17	71	96	11	90	146
  rs10021016	0.8982	0.25174	0.28533	0.22672	17	71	96	11	90	146
  rs10051148	0.8246	0.31903	0.29348	0.33806	19	70	95	26	115	106
  rs10054055	0.9114	0.31439	0.28804	0.33401	18	70	96	25	115	107
  rs10067895	0.8235	0.32151	0.29444	0.34156	19	68	93	26	114	103
  rs10100725	1	0.14849	0.11957	0.17004	1	42	141	8	68	171
  rs10128531	0.04404	0.17773	0.20718	0.1556	5	65	111	2	71	168
  rs10181743	0.7667	0.44511	0.47727	0.42181	42	84	50	39	127	77
  rs10199127	0.2788	0.277	0.32692	0.23975	14	91	77	14	89	141
  rs10270624	0.8741	0.18662	0.22826	0.15496	7	70	107	7	61	174
  rs1030006	0.6962	0.43387	0.47826	0.40081	45	86	53	34	130	83
  rs1031811	0.909	0.30471	0.32597	0.28893	23	72	86	17	107	120
  rs10430870	0.1902	0.24246	0.24457	0.24089	11	68	105	9	101	137
  rs10430870	0.1902	0.24246	0.24457	0.24089	11	68	105	9	101	137
  rs10469597	0.4689	0.29471	0.32941	0.26872	19	74	77	12	98	117
  rs10469597	0.4689	0.29471	0.32941	0.26872	19	74	77	12	98	117
  rs10478919	0.7398	0.32019	0.2962	0.33806	20	69	95	26	115	106
  rs10506623	0.132	0.40023	0.35054	0.43725	20	89	75	41	134	72
  rs10506623	0.132	0.40023	0.35054	0.43725	20	89	75	41	134	72
  rs10506626	0.2655	0.39186	0.33424	0.43496	19	85	80	41	132	73
  rs10506626	0.2655	0.39186	0.33424	0.43496	19	85	80	41	132	73
  rs10509477	0.4158	0.29419	0.32065	0.27439	18	82	84	23	89	134
  rs10517918	0.765	0.42099	0.46448	0.38797	45	80	58	32	123	86
  rs10517924	0.9228	0.46512	0.49454	0.44332	48	85	50	44	131	72
  rs10519362	0.1367	0.13109	0.15489	0.11336	6	45	133	5	46	196
  rs10520072	1	0.31585	0.28689	0.3374	18	69	96	25	116	105
  rs10737390	0.7588	0.38498	0.35714	0.40574	25	80	77	36	126	82
  rs10742851	0.8969	0.2471	0.2038	0.27935	5	65	114	22	94	131
  rs10743685	0.9175	0.36543	0.40217	0.33806	30	88	66	28	111	108
  rs10743685	0.9175	0.36543	0.40217	0.33806	30	88	66	28	111	108
  rs10749293	0.4125	0.29002	0.32065	0.26721	18	82	84	22	88	137
  rs10749294	0.3324	0.27262	0.29891	0.25304	15	80	89	21	83	143
  rs10753760	0.6768	0.39039	0.44253	0.35129	35	84	55	29	105	98
  rs10753760	0.6768	0.39039	0.44253	0.35129	35	84	55	29	105	98
  rs10772362	0.6967	0.24594	0.20652	0.2753	7	62	115	17	102	128
  rs10784891	0.4895	0.42657	0.38736	0.45547	30	81	71	44	137	66
  rs10784891	0.4895	0.42657	0.38736	0.45547	30	81	71	44	137	66
  rs10784891	0.4895	0.42657	0.38736	0.45547	30	81	71	44	137	66
  rs10787923	0.4129	0.2907	0.32065	0.26829	18	82	84	22	88	136
  rs10787924	0.3324	0.27262	0.29891	0.25304	15	80	89	21	83	143
  rs10787949	0.4183	0.29535	0.32337	0.27439	19	81	84	22	91	133
  rs10787951	0.4183	0.29535	0.32337	0.27439	19	81	84	22	91	133
  rs10787983	0.4158	0.29419	0.32065	0.27439	18	82	84	23	89	134
  rs10794733	0.9124	0.33017	0.29558	0.35625	13	81	87	32	107	101
  rs10818280	0.2268	0.32864	0.30055	0.34979	17	76	90	23	124	96
  rs10860586	1	0.49186	0.55163	0.44715	57	89	38	47	126	73
  rs10860586	1	0.49186	0.55163	0.44715	57	89	38	47	126	73
  rs10870473	0.4798	0.2967	0.2439	0.34	7	26	49	11	46	43
  rs10870473	0.4798	0.2967	0.2439	0.34	7	26	49	11	46	43
  rs10879240	5.55E−01	0.42674	0.38859	0.45528	31	81	72	44	136	66
  rs10879240	0.5549	0.42674	0.38859	0.45528	31	81	72	44	136	66
  rs10879242	0.1622	0.40371	0.35598	0.43927	21	89	74	42	133	72
  rs10879242	0.1622	0.40371	0.35598	0.43927	21	89	74	42	133	72
  rs10879245	0.1622	0.40371	0.35598	0.43927	21	89	74	42	133	72
  rs10879245	0.1622	0.40371	0.35598	0.43927	21	89	74	42	133	72
  rs10879249	0.1092	0.40116	0.35054	0.43902	20	89	75	41	134	71
  rs10879249	0.1092	0.40116	0.35054	0.43902	20	89	75	41	134	71
  rs10886429	0.4134	0.29138	0.31967	0.27033	18	81	84	22	89	135
  rs10886449	0.3355	0.27674	0.30163	0.25813	16	79	89	21	85	140
  rs10886451	0.3355	0.27674	0.30163	0.25813	16	79	89	21	85	140
  rs10886452	0.4183	0.29535	0.32337	0.27439	19	81	84	22	91	133
  rs10886456	0.3355	0.27674	0.30163	0.25813	16	79	89	21	85	140
  rs10886463	0.4176	0.29466	0.32337	0.27328	19	81	84	22	91	134
  rs10886465	0.3545	0.29582	0.32337	0.2753	19	81	84	23	90	134
  rs10886526	0.4158	0.29419	0.32065	0.27439	18	82	84	23	89	134
  rs10922903	0.7664	0.41395	0.39946	0.4248	25	97	62	47	115	84
  rs10941126	1	0.0232	0.01087	0.03239	0	4	180	0	16	231
  rs10941126	1	0.0232	0.01087	0.03239	0	4	180	0	16	231
  rs10947980	0.3433	0.28422	0.22554	0.32794	15	53	116	24	114	109
  rs11059376	0.8625	0.17233	0.21023	0.14407	7	60	109	4	60	172
  rs11072995	0.5795	0.22209	0.2459	0.20445	15	60	108	8	85	154
  rs11072995	0.5795	0.22209	0.2459	0.20445	15	60	108	8	85	154
  rs11081202	0.2973	0.29466	0.33152	0.26721	26	70	88	16	100	131
  rs11081202	0.2973	0.29466	0.33152	0.26721	26	70	88	16	100	131
  rs110965	0.739	0.3293	0.36782	0.30126	22	84	68	21	102	116
  rs11124962	0.7696	0.20766	0.24728	0.17814	7	77	100	10	68	169
  rs1116596	0.7398	0.32019	0.2962	0.33806	20	69	95	26	115	106
  rs11178531	0.4337	0.43735	0.40217	0.46356	32	84	68	46	137	64
  rs11178531	0.4337	0.43735	0.40217	0.46356	32	84	68	46	137	64
  rs11178583	0.1092	0.40116	0.35054	0.43902	20	89	75	41	134	71
  rs11178583	0.1092	0.40116	0.35054	0.43902	20	89	75	41	134	71
  rs11178589	0.1086	0.40139	0.35054	0.43927	20	89	75	41	135	71
  rs11178589	0.1086	0.40139	0.35054	0.43927	20	89	75	41	135	71
  rs11178594	0.132	0.40023	0.35054	0.43725	20	89	75	41	134	72
  rs11178594	0.132	0.40023	0.35054	0.43725	20	89	75	41	134	72
  rs11178602	0.132	0.40023	0.35054	0.43725	20	89	75	41	134	72
  rs11178602	0.132	0.40023	0.35054	0.43725	20	89	75	41	134	72
  rs11178648	0.3138	0.39559	0.34511	0.4332	21	85	78	41	132	74
  rs11178648	0.3138	0.39559	0.34511	0.4332	21	85	78	41	132	74
  rs11198877	0.4176	0.29466	0.32337	0.27328	19	81	84	22	91	134
  rs11198942	0.4158	0.29419	0.32065	0.27439	18	82	84	23	89	134
  rs11221075	0.8093	0.11385	0.09669	0.12653	2	31	148	4	54	187
  rs11242020	0.7399	0.32093	0.29781	0.33806	20	69	94	26	115	106
  rs11242021	1	0.31702	0.28962	0.3374	18	70	95	25	116	105
  rs11242022	1	0.31659	0.28962	0.33673	18	70	95	25	115	105
  rs11242023	1	0.31659	0.28962	0.33673	18	70	95	25	115	105
  rs1149349	1	0.13689	0.16033	0.11943	2	55	127	6	47	194
  rs1149350	0.1416	0.1814	0.22283	0.15041	9	64	111	10	54	182
  rs1149350	0.1416	0.1814	0.22283	0.15041	9	64	111	10	54	182
  rs11576627	0.1506	0.13817	0.16298	0.11992	7	45	129	5	49	192
  rs11576627	0.1506	0.13817	0.16298	0.11992	7	45	129	5	49	192
  rs11630050	0.7883	0.23202	0.25272	0.2166	16	61	107	8	91	148
  rs11630050	0.7883	0.23202	0.25272	0.2166	16	61	107	8	91	148
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  rs9310700	0.02563	0.34571	0.39946	0.30567	34	79	71	28	95	124
  rs9310700	0.02563	0.34571	0.39946	0.30567	34	79	71	28	95	124
  rs9310701	0.03283	0.34651	0.39946	0.30691	34	79	71	28	95	123
  rs9310704	0.03262	0.34859	0.39946	0.30992	34	79	71	28	94	120
  rs9319185	0.5855	0.32831	0.3587	0.30567	30	72	82	19	113	115
  rs9319186	0.5855	0.32831	0.3587	0.30567	30	72	82	19	113	115
  rs9327555	1	0.31702	0.28962	0.3374	18	70	95	25	116	105
  rs9403367	0.1465	0.24014	0.20109	0.26923	9	56	119	10	113	124
  rs9419608	0.08119	0.48595	0.51381	0.46545	55	76	50	55	119	72
  rs9426437	0.7588	0.38498	0.35714	0.40574	25	80	77	36	126	82
  rs9454967	0.1777	0.05916	0.08152	0.04251	1	28	155	2	17	228
  rs9635511	0.108	0.40281	0.38525	0.41598	28	85	70	33	137	74
  rs966583	0.1622	0.40371	0.35326	0.4413	21	88	75	42	134	71
  rs966583	0.1622	0.40371	0.35326	0.4413	21	88	75	42	134	71
  rs980263	0.0334	0.34687	0.39946	0.30769	34	79	71	28	96	123
  rs980264	0.0334	0.34687	0.39946	0.30769	34	79	71	28	96	123
  rs9812206	0.7864	0.09977	0.06793	0.12348	0	25	159	3	55	189
  rs9812206	0.7864	0.09977	0.06793	0.12348	0	25	159	3	55	189
  rs9813552	0.6016	0.10093	0.07065	0.12348	0	26	158	3	55	189
  rs9813552	0.6016	0.10093	0.07065	0.12348	0	26	158	3	55	189
  rs9815037	0.785	0.09884	0.06522	0.12398	0	24	160	3	55	188
  rs9815037	0.785	0.09884	0.06522	0.12398	0	24	160	3	55	188
  rs9819583	0.04132	0.34107	0.39674	0.2996	33	80	71	27	94	126
  rs9825349	0.7849	0.09861	0.06522	0.12348	0	24	160	3	55	189
  rs9825349	0.7849	0.09861	0.06522	0.12348	0	24	160	3	55	189
  rs9833118	0.02381	0.34964	0.4073	0.30705	34	77	67	28	92	121
  rs9833118	0.02381	0.34964	0.4073	0.30705	34	77	67	28	92	121
  rs9834217	0.785	0.09884	0.06557	0.12348	0	24	159	3	55	189
  rs9834217	0.785	0.09884	0.06557	0.12348	0	24	159	3	55	189
  rs9838563	0.03283	0.34651	0.39946	0.30691	34	79	71	28	95	123
  rs9840460	0.7849	0.09861	0.06522	0.12348	0	24	160	3	55	189
  rs9840460	0.7849	0.09861	0.06522	0.12348	0	24	160	3	55	189
  rs9840756	0.7849	0.09861	0.06522	0.12348	0	24	160	3	55	189
  rs9840756	0.7849	0.09861	0.06522	0.12348	0	24	160	3	55	189
  rs9847999	0.03262	0.34859	0.39946	0.30992	34	79	71	28	94	120
  rs9864769	0.0334	0.34687	0.39946	0.30769	34	79	71	28	96	123
  rs9866421	0.8452	0.43387	0.44022	0.42915	29	104	51	51	110	86
  rs987296	0.03184	0.3407	0.39674	0.29878	33	80	71	27	93	126
  rs9881685	0.7864	0.09977	0.06793	0.12348	0	25	159	3	55	189
  rs9881685	0.7864	0.09977	0.06793	0.12348	0	25	159	3	55	189
  rs992695	0.5472	0.27494	0.23913	0.30162	15	58	111	20	109	118
  rs992695	0.5472	0.27494	0.23913	0.30162	15	58	111	20	109	118
  rs9936999	0.6862	0.37349	0.42991	0.33099	18	56	33	15	64	63

• TABLE 16
  		ALLELE
  SNP rs #	SOURCE	(A1)	MODEL	NMISS	OR	SE	L95	U95	STAT	P

  rs77638540	Genotyped	T	DOM	443	0.3879	0.3691	0.1881	0.7996	−2.566	0.0103
  rs72746987	Genotyped	A	DOM	443	1.033	0.3495	0.5209	2.05	0.09422	0.9249
  rs10021016	Genotyped	G	GEN	443					6.477	0.03922
  rs10021016	Genotyped	G	REC	443	2.482	0.3826	1.172	5.253	2.375	0.01753
  rs10051148	Imputed	C	DOM	443	0.6399	0.1948	0.4368	0.9373	−2.293	0.02187
  rs10054055	Imputed	T	DOM	440	0.5872	0.2006	0.3963	0.8702	−2.653	0.007974
  rs10067895	Imputed	A	DOM	440	0.577	0.2025	0.388	0.8581	−2.716	0.006612
  rs10100725	Imputed	C	DOM	443	1.055	0.2111	0.6977	1.596	0.2549	0.7988
  rs10128531	Imputed	T	ADD	415	1.662	0.2062	1.11	2.49	2.465	0.0137
  rs10181743	Imputed	G	ADD	417	1.137	0.1442	0.8575	1.509	0.8934	0.3716
  rs10199127	Imputed	T	DOM	431	1.032	0.2018	0.6945	1.532	0.1537	0.8779
  rs10270624	Imputed	G	DOM	409	1.374	0.2138	0.904	2.09	1.488	0.1368
  rs1030006	Imputed	G	REC	434	0.87	0.2356	0.5483	1.381	−0.591	0.5545
  rs1031811	Imputed	A	REC	434	2.698	0.3294	1.415	5.145	3.013	0.002589
  rs10430870	Genotyped	G	GEN	443					8.277	0.01594
  rs10430870	Genotyped	G	REC	443	3.43	0.4334	1.467	8.021	2.84E+00	0.004451
  rs10469597	Imputed	A	GEN	411					2.673	0.2627
  rs10469597	Imputed	A	REC	411	1.249	0.4024	0.5677	2.749	0.5528	0.5804
  rs10478919	Imputed	G	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs10506623	Imputed	C	ADD	442	0.7806	0.1427	0.5901	1.033	−1.735	0.08266
  rs10506623	Imputed	C	DOM	442	0.7185	0.204	0.4817	1.072	−1.621	0.1051
  rs10506626	Imputed	A	ADD	443	0.7544	0.1415	0.5717	0.9954	−1.992	0.04634
  rs10506626	Imputed	A	DOM	443	0.6807	0.2015	0.4586	1.01	−1.909	0.05621
  rs10509477	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131
  rs10517918	Imputed	G	REC	433	0.972	0.2598	0.5841	1.618	−0.1092	0.9131
  rs10517924	Imputed	A	REC	442	1.079	0.2382	0.6766	1.721	0.3198	0.7491
  rs10519362	Imputed	G	DOM	434	1.656	0.2162	1.084	2.529	2.333	0.01967
  rs10520072	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs10737390	Imputed	T	DOM	418	1.128	0.213	0.7431	1.712	0.5659	0.5715
  rs10742851	Imputed	T	REC	443	1.673	0.3727	0.8057	3.473	1.38	0.1675
  rs10743685	Imputed	G	GEN	435					1.895	0.3878
  rs10743685	Imputed	G	REC	435	1.446	0.2691	0.8531	2.45	1.37	0.1708
  rs10749293	Imputed	G	DOM	441	1.442	0.1947	0.9847	2.113	1.881	0.05998
  rs10749294	Imputed	A	DOM	443	1.341	0.1934	0.9176	1.959	1.516	0.1296
  rs10753760	Imputed	T	ADD	423	0.9252	0.1361	0.7085	1.208	−0.5713	0.5678
  rs10753760	Imputed	T	GEN	423					0.3766	0.8284
  rs10772362	Imputed	T	ADD	443	0.8356	0.1722	0.5962	1.171	−1.043	0.297
  rs10784891	Imputed	C	ADD	422	0.7472	0.1404	0.5675	0.9839	−2.076	0.03794
  rs10784891	Imputed	C	DOM	422	0.7374	0.2125	0.4862	1.118	−1.433	0.1518
  rs10784891	Imputed	C	GEN	422					4.661	0.09727
  rs10787923	Imputed	G	DOM	439	1.448	0.1952	0.9878	2.123	1.897	0.05785
  rs10787924	Imputed	T	DOM	443	1.341	0.1934	0.9176	1.959	1.516	0.1296
  rs10787949	Imputed	A	DOM	442	1.352	0.1976	0.9177	1.991	1.525	0.1272
  rs10787951	Imputed	G	DOM	441	1.349	0.1976	0.9157	1.987	1.514	0.1299
  rs10787983	Imputed	C	DOM	441	1.351	0.1964	0.9194	1.986	1.532	0.1255
  rs10794733	Imputed	C	ADD	439	0.6594	0.1519	0.4896	0.888	−2.742	0.006112
  rs10818280	Imputed	C	DOM	432	0.6208	0.201	0.4186	0.9206	−2.371	0.01772
  rs10860586	Imputed	A	ADD	431	0.9019	0.1389	0.6869	1.184	−0.7436	0.4571
  rs10860586	Imputed	A	GEN	431					0.568	0.7528
  rs10870473	Imputed	A	ADD	177	1.273	0.2526	0.7757	2.088	0.9544	0.3399
  rs10870473	Imputed	A	DOM	177	1.887	0.3386	0.9717	3.664	1.875	0.06077
  rs10879240	Imputed	C	ADD	428	0.7296	0.1403	0.5542	0.9605	−2.247	0.02462
  rs10879240	Imputed	C	GEN	428					5.7	0.05785
  rs10879242	Imputed	A	ADD	421	0.7715	0.1445	0.5812	1.024	−1.795	0.07269
  rs10879242	Imputed	A	DOM	421	0.7102	0.2081	0.4724	1.068	−1.644	0.1001
  rs10879245	Imputed	G	ADD	421	0.7715	0.1445	0.5812	1.024	−1.795	0.07269
  rs10879245	Imputed	G	DOM	421	0.7102	0.2081	0.4724	1.068	−1.644	0.1001
  rs10879249	Imputed	T	ADD	440	0.7823	0.1427	0.5914	1.035	−1.72	0.08541
  rs10879249	Imputed	T	DOM	440	0.7247	0.2038	0.486	1.081	−1.58	0.1141
  rs10886429	Imputed	A	DOM	441	1.296	0.1967	0.8811	1.905	1.316	0.1881
  rs10886449	Imputed	G	DOM	440	1.337	0.1968	0.9089	1.966	1.475	0.1403
  rs10886451	Imputed	G	DOM	440	1.337	0.1968	0.9089	1.966	1.475	0.1403
  rs10886452	Imputed	A	DOM	440	1.376	0.1972	0.9349	2.025	1.619	0.1055
  rs10886456	Imputed	G	DOM	440	1.337	0.1968	0.9089	1.966	1.475	0.1403
  rs10886463	Imputed	C	DOM	442	1.352	0.1976	0.9177	1.991	1.525	0.1272
  rs10886465	Imputed	A	DOM	441	1.355	0.1976	0.9197	1.995	1.536	0.1245
  rs10886526	Imputed	C	DOM	439	1.364	0.197	0.9275	2.007	1.578	0.1146
  rs10922903	Imputed	C	REC	440	0.9678	0.2533	0.5891	1.59	−0.1294	0.897
  rs10941126	Imputed	G	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs10941126	Imputed	G	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs10947980	Imputed	G	ADD	439	1.004	0.1592	0.7347	1.371	0.0233	0.9814
  rs11059376	Imputed	T	ADD	401	1.086	0.1953	0.7409	1.593	0.424	0.6716
  rs11072995	Imputed	T	GEN	439					3.28	0.194
  rs11072995	Imputed	T	REC	439	2.198	0.4614	0.8897	5.43	1.707	0.08787
  rs11081202	Genotyped	G	GEN	443					8.643	0.01328
  rs11081202	Genotyped	G	REC	443	3.218	0.3982	1.475	7.022	2.935	0.003332
  rs110965	Imputed	C	GEN	420					11.84	0.002689
  rs11124962	Imputed	A	DOM	437	1.26	0.1969	0.8568	1.854	1.175	0.2401
  rs1116596	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs11178531	Imputed	A	ADD	439	0.7197	0.1371	0.5501	0.9416	−2.399	0.01643
  rs11178531	Imputed	A	DOM	439	0.6936	0.2116	0.4581	1.05	−1.729	0.08386
  rs11178583	Imputed	A	ADD	443	0.7883	0.1424	0.5963	1.042	−1.671	0.09473
  rs11178583	Imputed	A	DOM	443	0.7338	0.2032	0.4927	1.093	−1.523	0.1277
  rs11178589	Imputed	T	ADD	437	0.7796	0.1432	0.5888	1.032	−1.739	0.08199
  rs11178589	Imputed	T	DOM	437	0.7215	0.2047	0.4831	1.078	−1.595	0.1108
  rs11178594	Imputed	C	ADD	441	0.7716	0.1422	0.584	1.02	−1.824	0.06814
  rs11178594	Imputed	C	DOM	441	0.7044	0.202	0.4741	1.046	−1.735	0.08274
  rs11178602	Imputed	T	ADD	439	0.7699	0.1424	0.5824	1.018	−1.836	0.06634
  rs11178602	Imputed	T	DOM	439	0.7005	0.2027	0.4709	1.042	−1.757	0.079
  rs11178648	Imputed	T	ADD	440	0.754	0.1419	0.5709	0.9958	−1.99	0.04664
  rs11178648	Imputed	T	DOM	440	0.6786	0.2027	0.4561	1.01	−1.912	0.05581
  rs11198877	Imputed	T	DOM	441	1.369	0.1971	0.9302	2.014	1.593	0.1113
  rs11198942	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131
  rs11221075	Imputed	A	ADD	417	0.4912	0.2448	0.304	0.7936	−2.904	0.003685
  rs11242020	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs11242021	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs11242022	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs11242023	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs1149349	Imputed	T	DOM	434	1.154	0.221	0.7482	1.779	0.6474	0.5174
  rs1149350	Imputed	A	ADD	443	0.7733	0.1679	0.5564	1.075	−1.531	0.1258
  rs1149350	Imputed	A	DOM	443	0.8901	0.2092	0.5906	1.341	−0.5566	0.5778
  rs11576627	Imputed	T	ADD	441	1.439	0.1975	0.977	2.119	1.842	0.06547
  rs11576627	Imputed	T	DOM	441	1.57	0.2354	0.9899	2.491	1.917	0.05525
  rs11630050	Imputed	G	GEN	442					2.296	0.3173
  rs11630050	Imputed	G	REC	442	1.888	0.4309	0.8114	4.394	1.475	0.1402
  rs11633024	Imputed	C	GEN	442					2.296	0.3173
  rs11633024	Imputed	C	REC	442	1.888	0.4309	0.8114	4.394	1.475	0.1402
  rs11636298	Imputed	G	GEN	443					2.593	0.2734
  rs11636298	Imputed	G	REC	443	1.965	0.4472	0.8177	4.72	1.51	0.1311
  rs11637363	Imputed	C	GEN	420					2.573	0.2762
  rs11637363	Imputed	C	REC	420	1.982	0.4368	0.842	4.666	1.566	0.1173
  rs11637813	Imputed	A	GEN	442					2.296	0.3173
  rs11637813	Imputed	A	REC	442	1.888	0.4309	0.8114	4.394	1.475	0.1402
  rs11638043	Imputed	C	GEN	420					2.573	0.2762
  rs11638043	Imputed	C	REC	420	1.982	0.4368	0.842	4.666	1.566	0.1173
  rs11638115	Imputed	A	GEN	439					3.28	0.194
  rs11638115	Imputed	A	REC	439	2.198	0.4614	0.8897	5.43	1.707	0.08787
  rs11638444	Imputed	C	GEN	442					2.07	0.3552
  rs11682946	Imputed	A	ADD	86	3.591	0.6209	1.063	12.13	2.059	0.03949
  rs11682946	Imputed	A	DOM	86	3.591	0.6209	1.063	12.13	2.059	0.03949
  rs11717157	Imputed	T	ADD	442	1.051	0.1481	0.786	1.405	0.3342	0.7382
  rs11717157	Imputed	T	GEN	442					0.8899	0.6408
  rs11724055	Imputed	A	DOM	443	0.5373	0.2207	0.3486	0.828	−2.816	0.004869
  rs11743355	Imputed	C	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs11743355	Imputed	C	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs11746806	Imputed	T	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs11746806	Imputed	T	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs11746959	Imputed	T	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs11746959	Imputed	T	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs11749272	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs11839636	Imputed	C	GEN	441					0.9349	0.6266
  rs11839785	Imputed	C	GEN	441					0.9349	0.6266
  rs11853619	Imputed	C	GEN	440					2.44	0.2953
  rs11853619	Imputed	C	REC	440	1.946	0.4474	0.8098	4.677	1.488	0.1367
  rs11856780	Imputed	A	GEN	440					2.44	0.2953
  rs11856780	Imputed	A	REC	440	1.946	0.4474	0.8098	4.677	1.488	0.1367
  rs11901899	Imputed	A	DOM	426	1.452	0.1995	0.9821	2.147	1.869	0.06157
  rs11903290	Imputed	C	REC	434	2.698	0.3294	1.415	5.145	3.013	0.002589
  rs11909480	Imputed	G	ADD	439	0.4305	0.3702	0.2084	0.8894	−2.277	0.02282
  rs11909480	Imputed	G	DOM	439	0.3714	0.3963	0.1708	0.8077	−2.499	0.01246
  rs11910289	Imputed	T	ADD	440	1.815	0.2555	1.1	2.995	2.334	0.01959
  rs11910289	Imputed	T	DOM	440	1.911	0.2846	1.094	3.339	2.276	0.02285
  rs11920375	Genotyped	C	GEN	443					1.788	0.4089
  rs11926319	Imputed	G	DOM	443	1.007	0.269	0.5945	1.706	0.02639	0.9789
  rs11933744	Imputed	T	REC	440	0.8701	0.3394	0.4473	1.692	−0.4099	0.6819
  rs11934919	Imputed	C	REC	441	0.8636	0.341	0.4426	1.685	−0.43	0.6672
  rs11934957	Imputed	C	REC	441	0.8636	0.341	0.4426	1.685	−0.43	0.6672
  rs11959206	Imputed	A	REC	434	1.201	0.2381	0.7533	1.916	0.7701	0.4412
  rs12038613	Imputed	C	REC	404	0.8998	0.2554	0.5454	1.484	−0.4136	0.6791
  rs12151417	Imputed	T	DOM	442	1.517	0.199	1.027	2.241	2.095	0.03616
  rs12153185	Imputed	T	DOM	441	0.5728	0.2023	0.3853	0.8516	−2.754	0.005893
  rs12182651	Imputed	T	DOM	441	0.9744	0.2621	0.583	1.629	−0.09893	0.9212
  rs12235345	Imputed	C	DOM	443	1.768	0.3192	0.9457	3.305	1.785	0.07424
  rs12324786	Imputed	T	GEN	439					3.28	0.194
  rs12324786	Imputed	T	REC	439	2.198	0.4614	0.8897	5.43	1.707	0.08787
  rs12336958	Imputed	G	DOM	407	0.7989	0.209	0.5304	1.203	−1.074	0.2826
  rs12407412	Imputed	C	ADD	441	1.439	0.1975	0.977	2.119	1.842	0.06547
  rs12407412	Imputed	C	DOM	441	1.57	0.2354	0.9899	2.491	1.917	0.05525
  rs12418971	Imputed	C	GEN	436					8.323	0.01558
  rs12418971	Imputed	C	REC	436	3.381	0.4338	1.445	7.911	2.808	0.004979
  rs1241967	Imputed	T	REC	443	0.6598	0.3096	0.3596	1.211	−1.343	0.1794
  rs12420184	Imputed	G	DOM	438	1.429	0.2168	0.9343	2.185	1.647	0.09966
  rs12433968	Imputed	T	DOM	419	1.059	0.1998	0.7158	1.566	0.2862	0.7747
  rs12445477	Imputed	A	DOM	427	0.7231	0.2709	0.4252	1.23	−1.197	0.2315
  rs12447191	Genotyped	T	ADD	443	0.7641	0.1931	0.5233	1.116	−1.393	0.1636
  rs12447191	Genotyped	T	DOM	443	0.6902	0.216	0.452	1.054	−1.716	0.08611
  rs12465349	Imputed	A	REC	434	1.865	0.2195	1.213	2.867	2.839	0.004525
  rs1247340	Imputed	C	ADD	441	0.7681	0.1723	0.548	1.077	−1.531	0.1257
  rs1247340	Imputed	C	DOM	441	0.9041	0.2098	0.5993	1.364	−0.4802	0.6311
  rs1247341	Imputed	C	ADD	441	0.7805	0.1735	0.5555	1.097	−1.428	0.1532
  rs1247341	Imputed	C	DOM	441	0.919	0.2102	0.6087	1.387	−0.4021	0.6876
  rs1247343	Imputed	C	DOM	441	1.064	0.2203	0.6907	1.638	0.2798	0.7797
  rs12509758	Imputed	C	DOM	436	1.34	0.2022	0.9013	1.991	1.446	0.1481
  rs12515472	Imputed	A	DOM	443	1.913	0.2164	1.252	2.923	2.997	0.002728
  rs12548906	Imputed	G	ADD	415	1.763	0.1813	1.236	2.516	3.128	0.00176
  rs12596240	Imputed	G	DOM	443	0.9009	0.205	0.6028	1.346	−0.509	0.6107
  rs12618781	Imputed	A	DOM	440	1.082	0.2178	0.7061	1.658	0.3618	0.7175
  rs12678600	Imputed	A	DOM	439	0.7992	0.198	0.5421	1.178	−1.132	0.2575
  rs12692229	Imputed	T	ADD	443	1.608	0.1488	1.202	2.153	3.194	0.001404
  rs12713324	Imputed	T	DOM	443	1.501	0.1987	1.017	2.215	2.043	0.04105
  rs12719415	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs12820589	Imputed	G	ADD	418	0.882	0.1789	0.6212	1.252	−0.7022	0.4826
  rs12820589	Imputed	G	DOM	418	0.926	0.2078	0.6162	1.392	−0.3697	0.7116
  rs12831292	Imputed	G	ADD	436	0.7739	0.1429	0.5848	1.024	−1.794	0.0728
  rs12831292	Imputed	G	DOM	436	0.7047	0.2039	0.4725	1.051	−1.716	0.08609
  rs13012636	Imputed	G	REC	433	2.717	0.3295	1.424	5.183	3.034	0.002417
  rs13038146	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197
  rs13038146	Imputed	C	GEN	443					6.692	0.03523
  rs13038146	Imputed	C	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs13089860	Imputed	A	DOM	364	0.5987	0.2307	0.3809	0.941	−2.224	0.02617
  rs13102419	Imputed	T	REC	439	1.104	0.2389	0.6915	1.764	0.4158	0.6775
  rs13194907	Imputed	A	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367
  rs13194907	Imputed	A	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923
  rs13195745	Imputed	A	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367
  rs13195745	Imputed	A	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923
  rs13265054	Imputed	T	DOM	434	0.7541	0.1998	0.5098	1.116	−1.413	0.1577
  rs13273002	Imputed	A	GEN	443					0.08764	0.9571
  rs13282131	Imputed	C	ADD	440	1.295	0.1396	0.9848	1.702	1.85	0.06426
  rs13282131	Imputed	C	GEN	440					6.641	0.03614
  rs13282131	Imputed	C	REC	440	1.884	0.247	1.161	3.057	2.564	0.01034
  rs1330052	Imputed	G	GEN	443					1.596	0.4502
  rs1335721	Imputed	A	REC	406	0.8982	0.2552	0.5447	1.481	−0.4207	0.674
  rs1336382	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131
  rs1336383	Imputed	T	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131
  rs1336407	Imputed	T	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129
  rs1336409	Imputed	T	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129
  rs1336596	Imputed	A	DOM	440	0.9849	0.205	0.659	1.472	−0.07439	0.9407
  rs13387284	Imputed	A	DOM	408	1.094	0.2214	0.7089	1.689	0.4062	0.6846
  rs13401462	Imputed	C	DOM	417	0.8697	0.2292	0.555	1.363	−0.609	0.5425
  rs13409045	Imputed	T	ADD	442	1.009	0.1374	0.7712	1.321	0.06836	0.9455
  rs1349284	Imputed	C	GEN	443					0.308	0.8573
  rs1355715	Imputed	T	ADD	442	0.6617	0.3179	0.3549	1.234	−1.299	0.1939
  rs1357696	Imputed	A	GEN	434					2.08	0.3535
  rs1357698	Imputed	A	GEN	436					1.977	0.3722
  rs1357699	Imputed	T	GEN	436					1.977	0.3722
  rs1363273	Imputed	C	REC	421	0.9417	0.2317	0.598	1.483	−0.2592	0.7955
  rs1373601	Imputed	A	DOM	404	0.9323	0.2122	0.6151	1.413	−0.3303	0.7412
  rs1375829	Imputed	C	GEN	443					0.308	0.8573
  rs1395748	Imputed	G	DOM	441	1.231	0.195	0.8402	1.804	1.067	0.2859
  rs1414865	Imputed	T	DOM	442	1.352	0.1976	0.9177	1.991	1.525	0.1272
  rs1414873	Imputed	A	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129
  rs1414876	Imputed	C	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129
  rs1424643	Imputed	G	ADD	430	1.447	0.1648	1.048	1.999	2.244	0.02486
  rs1424643	Imputed	G	DOM	430	1.694	0.2023	1.14	2.518	2.606	0.009171
  rs1424648	Imputed	T	DOM	438	1.609	0.2007	1.085	2.384	2.368	0.01786
  rs1429321	Imputed	A	DOM	432	1.519	0.2006	1.025	2.251	2.084	0.03713
  rs1429326	Imputed	T	ADD	433	1.404	0.1719	1.003	1.967	1.975	0.04831
  rs1429326	Imputed	T	DOM	433	1.574	0.2049	1.053	2.352	2.213	0.02687
  rs1444741	Imputed	A	DOM	407	0.9777	0.2088	0.6493	1.472	−0.1082	0.9138
  rs1449916	Imputed	C	DOM	270	0.7246	0.2903	0.4102	1.28	−1.11	0.2671
  rs1459523	Imputed	A	ADD	442	1.051	0.1481	0.786	1.405	0.3342	0.7382
  rs1459523	Imputed	A	GEN	442					0.8899	0.6408
  rs1466352	Imputed	T	GEN	443					1.33	0.5142
  rs1466353	Imputed	G	GEN	443					1.33	0.5142
  rs1476714	Imputed	A	DOM	439	0.5924	0.2025	0.3983	0.8811	−2.585	0.009742
  rs1486723	Imputed	C	REC	434	0.5711	0.3144	0.3084	1.058	−1.782	0.07477
  rs1495375	Imputed	A	ADD	421	0.7715	0.1445	0.5812	1.024	−1.795	0.07269
  rs1495375	Imputed	A	DOM	421	0.7102	0.2081	0.4724	1.068	−1.644	0.1001
  rs1495381	Imputed	T	GEN	442					7.762	0.02063
  rs1495381	Imputed	T	REC	442	2.08	0.2834	1.194	3.626	2.584	0.009753
  rs1498061	Imputed	C	ADD	200	0.6227	0.2741	0.3639	1.066	−1.728	0.084
  rs1498992	Imputed	G	DOM	428	0.7274	0.1999	0.4916	1.076	−1.592	0.1114
  rs1499001	Imputed	T	DOM	437	0.7573	0.1974	0.5144	1.115	−1.409	0.159
  rs1512988	Imputed	A	ADD	442	0.7806	0.1427	0.5901	1.033	−1.735	0.08266
  rs1512988	Imputed	A	DOM	442	0.7185	0.204	0.4817	1.072	−1.621	0.1051
  rs1512989	Imputed	T	ADD	442	0.7806	0.1427	0.5901	1.033	−1.735	0.08266
  rs1512989	Imputed	T	DOM	442	0.7185	0.204	0.4817	1.072	−1.621	0.1051
  rs1512991	Imputed	T	ADD	425	0.7106	0.1399	0.5401	0.9348	−2.442	0.01462
  rs1512991	Imputed	T	DOM	425	0.6965	0.2131	0.4587	1.057	−1.698	0.08957
  rs1512991	Imputed	T	GEN	425					6.384	0.0411
  rs1524303	Imputed	T	GEN	436					1.005	0.6051
  rs1524306	Imputed	C	ADD	441	1.05	0.1481	0.7851	1.403	0.3265	0.744
  rs1524306	Imputed	C	GEN	441					0.8672	0.6482
  rs1524310	Imputed	G	ADD	438	1.063	0.1488	0.7944	1.424	0.4133	0.6794
  rs1524310	Imputed	G	GEN	438					0.7768	0.6781
  rs1524321	Imputed	C	GEN	441					1.192	0.5511
  rs1527059	Imputed	A	DOM	441	0.4524	0.2645	0.2693	0.7598	−2.999	0.002712
  rs152707	Imputed	A	ADD	443	1.066	0.1385	0.8128	1.399	0.4637	0.6429
  rs152707	Imputed	A	GEN	443					0.2887	0.8656
  rs152712	Genotyped	C	ADD	443	1.066	0.1385	0.8128	1.399	0.4637	0.6429
  rs152712	Genotyped	C	GEN	443					0.2887	0.8656
  rs1533994	Imputed	T	GEN	443					1.33	0.5142
  rs1535866	Imputed	G	DOM	440	1.405	0.2003	0.9487	2.081	1.697	0.08971
  rs1563773	Imputed	T	GEN	439					1.172	0.5564
  rs1563774	Imputed	T	GEN	439					1.172	0.5564
  rs1567740	Imputed	T	ADD	439	0.7805	0.1427	0.59	1.032	−1.736	0.08253
  rs1567740	Imputed	T	DOM	439	0.7204	0.2038	0.4831	1.074	−1.609	0.1076
  rs1572573	Imputed	A	DOM	396	1.019	0.2128	0.6715	1.546	0.08849	0.9295
  rs1577497	Imputed	C	REC	408	0.899	0.2549	0.5455	1.481	−0.418	0.676
  rs1581514	Imputed	T	ADD	429	1.06	0.1488	0.7919	1.419	0.3912	0.6957
  rs1581514	Imputed	T	GEN	429					1.004	0.6052
  rs1582321	Imputed	T	DOM	443	0.9009	0.205	0.6028	1.346	−0.509	0.6107
  rs1582322	Imputed	A	DOM	438	0.8697	0.2066	0.5801	1.304	−0.6757	0.4992
  rs1582323	Imputed	A	DOM	437	0.8751	0.2067	0.5836	1.312	−0.6457	0.5185
  rs1592485	Imputed	C	DOM	443	0.8723	0.2093	0.5787	1.315	−0.653	0.5138
  rs1600954	Imputed	T	ADD	423	1.193	0.1389	0.909	1.567	1.273	0.203
  rs1600954	Imputed	T	GEN	423					1.735	0.4199
  rs16938626	Imputed	G	DOM	435	0.7689	0.1982	0.5213	1.134	−1.326	0.1849
  rs16964300	Imputed	G	ADD	439	0.7656	0.1898	0.5278	1.111	−1.407	0.1593
  rs16964300	Imputed	G	DOM	439	0.6717	0.2145	0.4411	1.023	−1.855	0.06358
  rs16986282	Imputed	G	DOM	442	0.3565	0.3985	0.1632	0.7784	−2.589	0.009634
  rs17007620	Imputed	G	ADD	408	1.033	0.1717	0.7377	1.446	0.1877	0.8511
  rs17007620	Imputed	G	DOM	408	1.127	0.206	0.7523	1.687	0.5784	0.563
  rs17014326	Imputed	G	DOM	441	1.215	0.196	0.8276	1.785	0.9949	0.3198
  rs17047957	Imputed	C	DOM	439	1.801	0.2129	1.187	2.734	2.765	0.005699
  rs1705261	Imputed	A	REC	442	2.005	0.2767	1.166	3.449	2.514	0.01192
  rs17073341	Imputed	A	ADD	441	2.051	0.3685	0.9962	4.224	1.95	0.05123
  rs17073341	Imputed	A	DOM	441	2.316	0.4002	1.057	5.074	2.098	0.03591
  rs17138702	Imputed	G	ADD	443	1.127	0.1808	0.7906	1.606	0.6601	0.5092
  rs17189710	Imputed	T	ADD	430	1.382	0.1457	1.039	1.839	2.22	0.02639
  rs17189710	Imputed	T	GEN	430					6.752	0.03418
  rs17189710	Imputed	T	REC	430	2.127	0.2957	1.192	3.797	2.553	0.01069
  rs17310176	Imputed	T	ADD	443	0.6446	0.1904	0.4438	0.9362	−2.306	0.02109
  rs17310176	Imputed	T	DOM	443	0.6022	0.2152	0.395	0.9182	−2.357	0.01845
  rs17358860	Imputed	A	DOM	416	0.5513	0.2173	0.3601	0.844	−2.74	0.006139
  rs17370541	Imputed	T	GEN	397					0.1403	0.9322
  rs17370541	Imputed	T	REC	397	1.119	0.3013	0.62	2.02	0.3735	0.7088
  rs17526574	Imputed	G	GEN	443					0.4224	0.8096
  rs17530747	Imputed	T	DOM	374	1.033	0.2172	0.6751	1.582	0.1511	0.8799
  rs17649114	Imputed	C	DOM	440	1.776	0.2066	1.185	2.663	2.781	0.00542
  rs17766172	Imputed	A	REC	428	0.5776	0.3128	0.3129	1.066	−1.755	0.07928
  rs1818885	Imputed	G	GEN	443					0.8065	0.6682
  rs1832222	Imputed	G	DOM	443	1.344	0.1965	0.9144	1.975	1.504	0.1325
  rs1861327	Imputed	G	DOM	433	0.8914	0.2099	0.5908	1.345	−0.5476	0.584
  rs1868581	Imputed	G	ADD	436	1.033	0.1486	0.7722	1.383	0.2208	0.8253
  rs1868581	Imputed	G	GEN	436					0.5916	0.7439
  rs1874313	Imputed	A	ADD	443	0.7883	0.1424	0.5963	1.042	−1.671	0.09473
  rs1874313	Imputed	A	DOM	443	0.7338	0.2032	0.4927	1.093	−1.523	0.1277
  rs1876409	Imputed	C	DOM	443	1.204	0.1943	0.8227	1.762	0.9553	0.3394
  rs1913201	Imputed	G	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572
  rs1913201	Imputed	G	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546
  rs1913201	Imputed	G	GEN	432					6.276	0.04338
  rs1916922	Imputed	T	GEN	435					0.5208	0.7707
  rs1936871	Genotyped	G	DOM	443	0.7975	0.2097	0.5287	1.203	−1.079	0.2807
  rs1961157	Imputed	T	REC	442	1.145	0.2401	0.7152	1.833	0.5643	0.5725
  rs1987179	Imputed	T	ADD	417	0.617	0.1957	0.4205	0.9055	−2.467	0.01361
  rs1987179	Imputed	T	DOM	417	0.5176	0.2237	0.3339	0.8024	−2.944	0.00324
  rs1990023	Imputed	T	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs1995025	Imputed	C	DOM	433	1.717	0.216	1.124	2.621	2.501	0.01238
  rs2016194	Imputed	G	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs2023651	Imputed	T	ADD	429	1.235	0.1824	0.864	1.766	1.159	0.2466
  rs2024902	Imputed	A	ADD	442	1.087	0.2583	0.655	1.803	0.3216	0.7477
  rs2024902	Imputed	A	DOM	442	1.157	0.2804	0.6678	2.005	0.52	0.6031
  rs2025107	Imputed	A	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446
  rs2025108	Imputed	T	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446
  rs2031987	Imputed	T	GEN	443					0.4224	0.8096
  rs2052428	Imputed	C	DOM	427	0.7089	0.2176	0.4628	1.086	−1.581	0.1138
  rs2053230	Imputed	C	ADD	391	0.8193	0.2084	0.5446	1.233	−0.9565	0.3388
  rs2062448	Imputed	T	DOM	442	0.913	0.2688	0.5391	1.546	−0.3387	0.7348
  rs2063420	Imputed	C	REC	442	0.8647	0.2574	0.5221	1.432	−0.5649	0.5721
  rs2063591	Imputed	C	ADD	441	0.7255	0.1363	0.5554	0.9478	−2.353	0.01861
  rs2063591	Imputed	C	DOM	441	0.6936	0.2125	0.4573	1.052	−1.722	0.08515
  rs208026	Genotyped	A	DOM	443	1.559	0.1973	1.059	2.295	2.25	0.02446
  rs208029	Imputed	T	DOM	422	1.924	0.2083	1.279	2.894	3.142	0.001679
  rs208757	Imputed	G	DOM	435	1.858	0.2057	1.241	2.78	3.011	0.002601
  rs2095586	Imputed	A	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129
  rs2095606	Imputed	A	DOM	436	0.9481	0.2038	0.6359	1.414	−0.2614	0.7938
  rs2102374	Imputed	A	ADD	437	1.135	0.1587	0.8318	1.549	0.7991	0.4242
  rs2102374	Imputed	A	DOM	437	1.187	0.1949	0.8099	1.739	0.8784	0.3797
  rs2108426	Imputed	C	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs2110664	Imputed	A	DOM	399	1.47	0.2058	0.9818	2.2	1.871	0.06136
  rs2132242	Imputed	A	ADD	440	0.7679	0.1423	0.5811	1.015	−1.856	0.06344
  rs2132242	Imputed	A	DOM	440	0.6978	0.2022	0.4695	1.037	−1.78	0.07505
  rs2158958	Imputed	A	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs2158961	Imputed	G	DOM	443	0.6399	0.1948	0.4368	0.9373	−2.293	0.02187
  rs2163046	Imputed	A	DOM	436	1.529	0.2	1.033	2.263	2.124	0.03363
  rs2180286	Imputed	G	DOM	443	0.587	0.2201	0.3813	0.9037	−2.42	0.01553
  rs2180684	Imputed	A	DOM	433	1.876	0.2393	1.174	2.999	2.629	0.00857
  rs2188079	Imputed	C	ADD	443	1.028	0.1399	0.7818	1.353	0.2006	0.841
  rs2188079	Imputed	C	GEN	443					1.2	0.5489
  rs2190598	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs2190600	Imputed	A	DOM	440	0.577	0.2025	0.388	0.8581	−2.716	0.006612
  rs2224184	Genotyped	T	DOM	443	0.587	0.2201	0.3813	0.9037	−2.42	0.01553
  rs2247066	Imputed	A	DOM	441	1.231	0.195	0.8402	1.804	1.067	0.2859
  rs2248236	Imputed	C	ADD	443	0.6625	0.1753	0.4699	0.9342	−2.348	0.01888
  rs2248236	Imputed	C	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.002602
  rs2265733	Imputed	C	ADD	437	1.135	0.1587	0.8318	1.549	0.7991	0.4242
  rs2265733	Imputed	C	DOM	437	1.187	0.1949	0.8099	1.739	0.8784	0.3797
  rs2270584	Imputed	A	ADD	441	0.7517	0.1419	0.5692	0.9927	−2.011	0.04429
  rs2270584	Imputed	A	DOM	441	0.6747	0.2026	0.4536	1.004	−1.942	0.05211
  rs2270586	Imputed	A	ADD	442	0.7586	0.1416	0.5748	1.001	−1.952	0.05099
  rs2270586	Imputed	A	DOM	442	0.6883	0.2018	0.4634	1.022	−1.851	0.06423
  rs229775	Imputed	A	REC	443	0.6598	0.3096	0.3596	1.211	−1.343	0.1794
  rs229815	Imputed	T	REC	432	0.6306	0.295	0.3537	1.124	−1.563	0.1181
  rs229829	Imputed	C	REC	413	0.5855	0.2981	0.3264	1.05	−1.795	0.07258
  rs229831	Imputed	A	REC	441	0.6194	0.315	0.3341	1.148	−1.521	0.1283
  rs2317057	Imputed	T	ADD	368	0.5936	0.1943	0.4056	0.8687	−2.685	0.007256
  rs2322100	Genotyped	T	REC	443	2.61	0.3935	1.207	5.644	2.438	0.01477
  rs2322101	Imputed	A	REC	440	2.67	0.3944	1.233	5.784	2.491	0.01275
  rs2327929	Imputed	G	REC	441	1.411	0.2475	0.8684	2.291	1.39	0.1645
  rs2332844	Imputed	A	ADD	282	1.301	0.2435	0.807	2.096	1.079	0.2804
  rs2332844	Imputed	A	REC	282	1.427	0.2711	0.8386	2.427	1.311	0.19
  rs2349170	Imputed	G	DOM	443	1.414	0.198	0.9594	2.085	1.751	0.07997
  rs2356722	Imputed	G	DOM	443	1.255	0.1956	0.8553	1.841	1.161	0.2457
  rs2364956	Imputed	T	ADD	415	1.168	0.1854	0.8122	1.68	0.838	0.402
  rs2373793	Imputed	G	ADD	435	1.56	0.1996	1.055	2.307	2.227	0.02596
  rs2373793	Imputed	G	DOM	435	1.599	0.2233	1.032	2.477	2.103	0.03546
  rs238252	Imputed	G	ADD	434	1.155	0.2029	0.7763	1.72	0.712	0.4765
  rs238252	Imputed	G	DOM	434	1.191	0.2236	0.7681	1.846	0.7803	0.4352
  rs2383903	Imputed	G	DOM	443	0.7568	0.1968	0.5146	1.113	−1.416	0.1569
  rs2387945	Imputed	G	DOM	436	1.747	0.2151	1.146	2.663	2.593	0.009513
  rs2389863	Imputed	A	DOM	432	0.5655	0.2068	0.377	0.8481	−2.756	0.005845
  rs2389866	Imputed	C	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.002602
  rs2389869	Imputed	C	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.002602
  rs2389870	Genotyped	C	DOM	443	0.5285	0.2176	0.345	0.8096	−2.931	0.003382
  rs2418494	Imputed	G	ADD	423	0.6959	0.1462	0.5225	0.9268	−2.48	0.01314
  rs2418494	Imputed	G	GEN	423					6.342	0.04195
  rs2418541	Imputed	A	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs2418542	Imputed	A	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs2423556	Imputed	C	DOM	433	0.5931	0.2244	0.382	0.9206	−2.328	0.01989
  rs2437688	Imputed	C	ADD	443	2.041	0.2367	1.284	3.247	3.014	0.002576
  rs2456809	Imputed	G	DOM	438	1.173	0.1954	0.7998	1.721	0.8168	0.414
  rs2456811	Imputed	T	ADD	436	1.146	0.1589	0.8394	1.565	0.8588	0.3905
  rs2456811	Imputed	T	DOM	436	1.202	0.1953	0.8198	1.763	0.9425	0.346
  rs2476976	Imputed	C	DOM	442	1.391	0.1963	0.9466	2.044	1.68	0.09288
  rs2484911	Imputed	A	DOM	443	1.347	0.1959	0.9174	1.977	1.52	0.1285
  rs2488557	Imputed	C	DOM	431	0.924	0.2286	0.5904	1.446	−0.3457	0.7296
  rs250162	Imputed	C	ADD	429	0.6714	0.1771	0.4745	0.9501	−2.249	0.02451
  rs250162	Imputed	C	DOM	429	0.6417	0.2018	0.4321	0.953	−2.199	0.02791
  rs2560708	Imputed	T	ADD	436	0.7416	0.1846	0.5164	1.065	−1.619	0.1054
  rs2617841	Imputed	G	DOM	412	0.7326	0.2034	0.4917	1.092	−1.53	0.1261
  rs2622499	Imputed	G	DOM	443	0.5404	0.2044	0.362	0.8067	−3.011	0.002602
  rs264129	Imputed	T	DOM	443	0.6399	0.1948	0.4368	0.9373	−2.293	0.02187
  rs2642936	Imputed	T	ADD	428	0.9768	0.1833	0.682	1.399	−0.1281	0.8981
  rs2660633	Imputed	A	DOM	443	1.204	0.1943	0.8227	1.762	0.9553	0.3394
  rs2660634	Imputed	C	DOM	443	1.204	0.1943	0.8227	1.762	0.9553	0.3394
  rs2660648	Imputed	A	ADD	437	1.135	0.1587	0.8318	1.549	0.7991	0.4242
  rs2660648	Imputed	A	DOM	437	1.187	0.1949	0.8099	1.739	0.8784	0.3797
  rs2681505	Imputed	T	ADD	443	0.8499	0.1719	0.6068	1.19	−0.9458	0.3442
  rs277411	Imputed	G	DOM	442	1.109	0.3436	0.5658	2.175	0.3022	0.7625
  rs2832634	Imputed	G	ADD	442	1.764	0.2529	1.075	2.896	2.245	0.02478
  rs2832637	Imputed	T	ADD	442	1.764	0.2529	1.075	2.896	2.245	0.02478
  rs2843167	Imputed	A	DOM	442	1.111	0.1972	0.7547	1.635	0.5327	0.5943
  rs2876227	Imputed	C	ADD	442	1.389	0.1445	1.046	1.843	2.272	0.02309
  rs2876227	Imputed	C	GEN	442					6.593	0.03701
  rs2882097	Imputed	A	DOM	443	1.364	0.1959	0.9291	2.003	1.584	0.1131
  rs2909862	Imputed	G	DOM	416	1.083	0.2178	0.7067	1.659	0.3656	0.7146
  rs3001945	Imputed	T	DOM	435	1.72	0.2156	1.127	2.625	2.515	0.0119
  rs3011020	Imputed	C	DOM	436	1.747	0.2151	1.146	2.663	2.593	0.009513
  rs36071725	Genotyped	C	ADD	443	0.9696	0.1509	0.7214	1.303	−0.2047	0.8378
  rs36071725	Genotyped	C	GEN	443					0.6419	0.7255
  rs373983	Imputed	G	DOM	414	1.954	0.2168	1.277	2.988	3.089	0.002005
  rs3743794	Imputed	G	DOM	434	0.8871	0.2078	0.5903	1.333	−0.5765	0.5643
  rs3756154	Imputed	C	ADD	416	0.6137	0.1939	0.4196	0.8975	−2.518	0.01182
  rs3756154	Imputed	C	DOM	416	0.5162	0.2209	0.3348	0.7959	−2.993	0.00276
  rs3775850	Imputed	A	DOM	443	0.5373	0.2207	0.3486	0.828	−2.816	0.004869
  rs3775851	Imputed	C	DOM	443	0.5373	0.2207	0.3486	0.828	−2.816	0.004869
  rs3793044	Imputed	C	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367
  rs3793044	Imputed	C	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923
  rs3793053	Imputed	C	DOM	436	0.9919	0.2675	0.5872	1.676	−0.03035	0.9758
  rs3796246	Imputed	G	DOM	442	0.9829	0.2682	0.5811	1.663	−0.06425	0.9488
  rs3806003	Imputed	A	ADD	443	1.091	0.2583	0.6574	1.81	0.3362	0.7367
  rs3806003	Imputed	A	DOM	443	1.162	0.2804	0.6707	2.013	0.5355	0.5923
  rs3806004	Imputed	T	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446
  rs3806010	Imputed	T	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446
  rs3806014	Imputed	T	DOM	430	1.002	0.2658	0.5954	1.688	0.00889	0.9929
  rs3806015	Imputed	A	DOM	426	0.9945	0.2663	0.5902	1.676	−0.02059	0.9836
  rs3806018	Imputed	A	DOM	442	0.982	0.2619	0.5877	1.641	−0.06944	0.9446
  rs3806019	Imputed	A	DOM	438	0.9676	0.2625	0.5784	1.619	−0.1255	0.9001
  rs3806024	Imputed	T	DOM	442	1.001	0.2605	0.601	1.669	0.00521	0.9958
  rs3915080	Imputed	A	GEN	436					1.977	0.3722
  rs3942254	Imputed	T	ADD	420	0.7577	0.1442	0.5712	1.005	−1.925	0.05425
  rs3942254	Imputed	T	DOM	420	0.6591	0.2081	0.4383	0.991	−2.004	0.04512
  rs3945085	Imputed	A	DOM	441	1.324	0.1969	0.9003	1.948	1.427	0.1537
  rs3976737	Imputed	G	ADD	377	1.239	0.1939	0.8469	1.811	1.103	0.27
  rs399485	Imputed	A	DOM	437	1.648	0.1968	1.12	2.423	2.538	0.01116
  rs4029119	Imputed	G	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs4029119	Imputed	G	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs4076201	Imputed	G	GEN	420					2.573	0.2762
  rs4076201	Imputed	G	REC	420	1.982	0.4368	0.842	4.666	1.566	0.1173
  rs41395945	Imputed	G	ADD	441	1.822	0.2555	1.104	3.006	2.348	0.01887
  rs41395945	Imputed	G	DOM	441	1.919	0.2846	1.099	3.352	2.29	0.022
  rs4146972	Genotyped	T	DOM	443	1.832	0.2123	1.208	2.777	2.851	0.004361
  rs4238087	Imputed	G	DOM	402	0.5579	0.251	0.3411	0.9125	−2.325	0.02009
  rs4251569	Imputed	T	ADD	441	0.645	0.2176	0.4211	0.9882	−2.015	0.04394
  rs4251569	Imputed	T	DOM	441	0.5571	0.243	0.346	0.897	−2.407	0.01607
  rs4273613	Imputed	T	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs4273613	Imputed	T	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs4291049	Imputed	T	REC	432	1.16	0.2386	0.727	1.852	0.6237	0.5328
  rs4315598	Imputed	T	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197
  rs4315598	Imputed	T	GEN	443					6.692	0.03523
  rs4315598	Imputed	T	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs4321395	Imputed	A	DOM	408	1.094	0.2214	0.7089	1.689	0.4062	0.6846
  rs4321596	Genotyped	T	REC	443	2.583	0.4532	1.063	6.278	2.094	0.03627
  rs4324417	Imputed	T	DOM	443	1.061	0.217	0.6932	1.623	0.2716	0.7859
  rs4328619	Genotyped	G	DOM	443	0.5613	0.2195	0.365	0.8631	−2.631	0.008525
  rs4338909	Imputed	T	ADD	440	0.998	0.1323	0.7701	1.293	−0.01507	0.988
  rs4370878	Imputed	G	DOM	440	1.312	0.1971	0.8916	1.931	1.378	0.1682
  rs4379434	Genotyped	T	DOM	443	0.9929	0.2031	0.6669	1.478	−0.03512	0.972
  rs4416407	Imputed	T	DOM	437	1.387	0.2325	0.8796	2.188	1.408	0.1591
  rs4417899	Imputed	C	REC	437	0.7208	0.2325	0.457	1.137	−1.408	0.1591
  rs4442732	Imputed	A	ADD	335	0.9155	0.1782	0.6456	1.298	−0.4952	0.6205
  rs4444612	Imputed	G	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197
  rs4444612	Imputed	G	GEN	443					6.692	0.03523
  rs4444612	Imputed	G	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs4450660	Imputed	C	DOM	438	1.275	0.1965	0.8675	1.874	1.236	0.2163
  rs4509702	Imputed	C	DOM	440	1.312	0.1971	0.8916	1.931	1.378	0.1682
  rs4526920	Imputed	G	GEN	443					0.4224	0.8096
  rs4533145	Imputed	T	DOM	441	1.764	0.2281	1.128	2.759	2.489	0.0128
  rs4557006	Imputed	A	DOM	401	1.096	0.2227	0.7085	1.696	0.4124	0.6801
  rs4570530	Imputed	C	DOM	440	1.312	0.1971	0.8916	1.931	1.378	0.1682
  rs4615971	Imputed	C	DOM	440	1.347	0.1965	0.9164	1.98	1.516	0.1296
  rs4628119	Imputed	A	DOM	442	1.055	0.1992	0.7139	1.559	0.268	0.7887
  rs4664443	Imputed	G	ADD	442	1.009	0.1374	0.7712	1.321	0.06836	0.9455
  rs4688259	Imputed	T	DOM	438	1.386	0.2325	0.8791	2.187	1.405	0.1599
  rs4688632	Imputed	G	REC	429	0.6822	0.2335	0.4316	1.078	−1.638	0.1014
  rs4695284	Imputed	A	ADD	194	1.444	0.3862	0.6775	3.079	0.9518	0.3412
  rs4700302	Imputed	A	ADD	399	1.136	0.2485	0.6982	1.85	0.5147	0.6067
  rs4702720	Imputed	A	ADD	359	0.757	0.1808	0.5311	1.079	−1.54	0.1236
  rs4702720	Imputed	A	DOM	359	0.6462	0.2205	0.4194	0.9956	−1.98	0.04769
  rs4711091	Genotyped	G	GEN	443					1.334	0.5133
  rs4714484	Imputed	A	ADD	439	0.8396	0.1992	0.5682	1.241	−0.8775	0.3802
  rs4736802	Imputed	G	DOM	442	0.9844	0.2032	0.661	1.466	−0.07725	0.9384
  rs4760785	Imputed	A	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572
  rs4760785	Imputed	A	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546
  rs4760785	Imputed	A	GEN	432					6.276	0.04338
  rs4760894	Imputed	T	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572
  rs4760894	Imputed	T	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546
  rs4760894	Imputed	T	GEN	432					6.276	0.04338
  rs4760895	Imputed	A	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572
  rs4760895	Imputed	A	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546
  rs4760895	Imputed	A	GEN	432					6.276	0.04338
  rs4764738	Imputed	A	ADD	430	0.9549	0.142	0.723	1.261	−0.3248	0.7454
  rs4764738	Imputed	A	GEN	430					0.6545	0.7209
  rs4764974	Imputed	T	ADD	431	0.9019	0.1389	0.6869	1.184	−0.7436	0.4571
  rs4764974	Imputed	T	GEN	431					0.568	0.7528
  rs4798366	Imputed	G	REC	429	2.754	0.3596	1.361	5.574	2.817	0.004844
  rs483159	Imputed	T	DOM	386	1.953	0.219	1.271	2.999	3.056	0.002245
  rs4836502	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs4836507	Imputed	C	DOM	442	0.5803	0.2019	0.3906	0.862	−2.696	0.007028
  rs4836744	Imputed	A	ADD	443	0.7176	0.155	0.5296	0.9724	−2.141	0.03229
  rs4836744	Imputed	A	DOM	443	0.6515	0.1952	0.4444	0.9552	−2.195	0.02818
  rs4848944	Genotyped	C	REC	443	0.7027	0.2417	0.4375	1.128	−1.46	0.1443
  rs4851529	Imputed	A	DOM	442	0.6342	0.203	0.426	0.944	−2.244	0.02485
  rs4851531	Imputed	T	DOM	442	0.6071	0.2055	0.4058	0.9082	−2.428	0.01517
  rs4858046	Genotyped	T	GEN	443					1.33	0.5142
  rs4878214	Imputed	A	ADD	261	0.7554	0.1893	0.5212	1.095	−1.481	0.1385
  rs4880803	Imputed	A	ADD	439	0.6594	0.1519	0.4896	0.888	−2.742	0.006112
  rs489441	Imputed	G	ADD	409	1.224	0.1644	0.8866	1.689	1.228	0.2195
  rs489441	Imputed	G	DOM	409	1.384	0.2043	0.9276	2.066	1.592	0.1114
  rs4896568	Imputed	T	DOM	410	1.056	0.2054	0.7057	1.579	0.2631	0.7925
  rs4938851	Imputed	T	DOM	443	1.781	0.2035	1.195	2.654	2.835	0.004584
  rs4964416	Imputed	C	DOM	443	0.6905	0.2178	0.4506	1.058	−1.701	0.08902
  rs5756669	Imputed	C	DOM	443	1.061	0.217	0.6932	1.623	0.2716	0.7859
  rs6033138	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197
  rs6033138	Imputed	C	GEN	443					6.692	0.03523
  rs6033138	Imputed	C	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs6040619	Imputed	C	ADD	439	1.429	0.1436	1.079	1.894	2.487	0.01287
  rs6040619	Imputed	C	GEN	439					7.276	0.02631
  rs6040619	Imputed	C	REC	439	2.094	0.2899	1.186	3.695	2.549	0.01081
  rs6040625	Imputed	T	ADD	442	1.414	0.1431	1.068	1.871	2.419	0.01557
  rs6040625	Imputed	T	GEN	442					6.967	0.0307
  rs6040625	Imputed	T	REC	442	2.067	0.2898	1.171	3.646	2.505	0.01224
  rs6040630	Imputed	A	ADD	441	1.401	0.1436	1.058	1.857	2.349	0.01881
  rs6040630	Imputed	A	GEN	441					6.767	0.03392
  rs6040630	Imputed	A	REC	441	2.062	0.2897	1.168	3.637	2.497	0.01252
  rs6040633	Imputed	A	ADD	442	1.391	0.1433	1.05	1.842	2.302	0.02133
  rs6040633	Imputed	A	GEN	442					6.683	0.03539
  rs6040633	Imputed	A	REC	442	2.063	0.2897	1.169	3.641	2.5	0.01242
  rs6040634	Imputed	T	ADD	441	1.404	0.1433	1.06	1.859	2.368	0.01791
  rs6040634	Imputed	T	GEN	441					6.855	0.03246
  rs6040634	Imputed	T	REC	441	2.069	0.2898	1.173	3.652	2.509	0.0121
  rs6040636	Imputed	T	ADD	443	1.371	0.1435	1.034	1.816	2.196	0.0281
  rs6040636	Imputed	T	GEN	443					6.529	0.03821
  rs6040636	Imputed	T	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs6040638	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197
  rs6040638	Imputed	C	GEN	443					6.692	0.03523
  rs6040638	Imputed	C	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs6040644	Imputed	A	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197
  rs6040644	Imputed	A	GEN	443					6.692	0.03523
  rs6040644	Imputed	A	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs6040667	Imputed	T	ADD	424	1.422	0.1447	1.071	1.888	2.432	0.01502
  rs6040667	Imputed	T	GEN	424					7.201	0.02731
  rs6040667	Imputed	T	REC	424	2.108	0.2894	1.195	3.717	2.576	0.009982
  rs6040668	Imputed	C	ADD	440	1.398	0.1448	1.053	1.857	2.314	0.02064
  rs6040668	Imputed	C	GEN	440					6.796	0.03345
  rs6040668	Imputed	C	REC	440	2.097	0.2944	1.178	3.735	2.516	0.01186
  rs6043066	Genotyped	G	DOM	443	1.485	0.2038	0.9963	2.215	1.942	0.05215
  rs6048146	Imputed	G	DOM	443	2.548	0.4417	1.072	6.055	2.117	0.03423
  rs6082725	Genotyped	T	DOM	443	2.548	0.4417	1.072	6.055	2.117	0.03423
  rs6131206	Imputed	C	ADD	424	1.493	0.1554	1.101	2.025	2.581	0.009855
  rs6131208	Imputed	T	ADD	440	1.387	0.1445	1.045	1.841	2.263	0.02364
  rs6131208	Imputed	T	GEN	440					6.748	0.03426
  rs6131208	Imputed	T	REC	440	2.109	0.2945	1.184	3.756	2.534	0.01129
  rs6134243	Imputed	C	ADD	443	1.389	0.1433	1.049	1.839	2.291	0.02197
  rs6134243	Imputed	C	GEN	443					6.692	0.03523
  rs6134243	Imputed	C	REC	443	2.069	0.2898	1.172	3.65	2.508	0.01214
  rs6136020	Imputed	A	DOM	441	1.061	0.2134	0.6982	1.612	0.2765	0.7822
  rs613799	Imputed	C	DOM	420	1.391	0.2013	0.9378	2.065	1.641	0.1008
  rs644041	Imputed	G	ADD	402	1.202	0.1659	0.8685	1.664	1.111	0.2667
  rs644041	Imputed	G	DOM	402	1.351	0.2068	0.9007	2.026	1.454	0.1459
  rs647645	Imputed	C	ADD	441	0.9195	0.1447	0.6925	1.221	−0.5801	0.5619
  rs647645	Imputed	C	GEN	441					2.764	0.2511
  rs647645	Imputed	C	REC	441	1.143	0.2499	0.7005	1.866	0.5357	0.5922
  rs6495554	Imputed	C	GEN	443					2.593	0.2734
  rs6495554	Imputed	C	REC	443	1.965	0.4472	0.8177	4.72	1.51	0.1311
  rs6495555	Imputed	C	GEN	443					2.593	0.2734
  rs6495555	Imputed	C	REC	443	1.965	0.4472	0.8177	4.72	1.51	0.1311
  rs6544728	Imputed	T	DOM	439	1.333	0.197	0.9058	1.961	1.458	0.1448
  rs6550705	Imputed	C	ADD	443	1.048	0.1481	0.7837	1.401	0.3148	0.7529
  rs6550705	Imputed	C	GEN	443					0.8065	0.6682
  rs6550707	Imputed	T	GEN	442					1.263	0.5317
  rs658108	Imputed	A	DOM	443	1.347	0.1959	0.9174	1.977	1.52	0.1285
  rs6593441	Imputed	A	DOM	412	1.402	0.2318	0.89	2.208	1.457	0.1451
  rs668732	Imputed	A	DOM	442	0.9925	0.2194	0.6457	1.526	−0.0343	0.9726
  rs671041	Imputed	A	DOM	443	1.347	0.1959	0.9174	1.977	1.52	0.1285
  rs6719700	Imputed	A	ADD	434	1.378	0.1747	0.9785	1.941	1.836	0.06643
  rs6719700	Imputed	A	DOM	434	1.551	0.207	1.034	2.327	2.121	0.03391
  rs6722640	Imputed	T	DOM	441	0.5987	0.207	0.399	0.8983	−2.478	0.01322
  rs6743092	Imputed	T	ADD	434	1.239	0.1411	0.9401	1.634	1.522	0.128
  rs6743092	Imputed	T	GEN	434					9.618	0.008155
  rs6743092	Imputed	T	REC	434	1.9	0.2284	1.214	2.973	2.809	0.004962
  rs6744759	Imputed	G	REC	436	2.691	0.3293	1.411	5.132	3.006	0.002648
  rs6746170	Imputed	A	DOM	442	1.346	0.196	0.9168	1.977	1.517	0.1293
  rs6759922	Imputed	A	DOM	408	1.094	0.2214	0.7089	1.689	0.4062	0.6846
  rs6769864	Imputed	T	GEN	436					1.045	0.5932
  rs6773932	Imputed	C	GEN	436					1.977	0.3722
  rs6774353	Imputed	A	GEN	443					0.8065	0.6682
  rs6781670	Imputed	C	GEN	443					0.308	0.8573
  rs6786431	Imputed	A	GEN	436					1.977	0.3722
  rs6789091	Imputed	T	GEN	436					1.977	0.3722
  rs6791296	Imputed	T	ADD	426	0.6456	0.2242	0.416	1.002	−1.952	0.05092
  rs6792662	Imputed	G	DOM	434	1.389	0.2326	0.8802	2.191	1.411	0.1581
  rs6797574	Imputed	G	GEN	436					1.977	0.3722
  rs6797882	Imputed	G	GEN	436					1.977	0.3722
  rs6805139	Imputed	G	DOM	442	1.417	0.2237	0.9138	2.197	1.557	0.1194
  rs6806043	Imputed	C	ADD	441	1.05	0.1481	0.7851	1.403	0.3265	0.744
  rs6806043	Imputed	C	GEN	441					0.8672	0.6482
  rs6850716	Imputed	C	GEN	443					1.373	0.5034
  rs6867153	Imputed	A	REC	434	1.201	0.2381	0.7533	1.916	0.7701	0.4412
  rs687047	Imputed	C	ADD	443	0.5642	0.2311	0.3587	0.8876	−2.476	0.01329
  rs6871041	Imputed	G	DOM	418	0.6503	0.2006	0.4389	0.9635	−2.145	0.03192
  rs688358	Imputed	A	ADD	427	0.5756	0.2319	0.3653	0.9068	−2.382	0.01723
  rs6888012	Imputed	A	REC	432	1.203	0.2383	0.7542	1.919	0.7764	0.4375
  rs6908481	Imputed	C	REC	400	1.391	0.2704	0.8186	2.363	1.22	0.2226
  rs7032231	Imputed	A	ADD	423	1.514	0.148	1.133	2.023	2.802	0.005072
  rs7067638	Imputed	T	DOM	442	1.413	0.2274	0.905	2.207	1.521	0.1283
  rs7077799	Imputed	A	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129
  rs7082163	Imputed	A	ADD	440	1.236	0.2162	0.809	1.888	0.9797	0.3273
  rs7082163	Imputed	A	DOM	440	1.386	0.2298	0.8837	2.175	1.422	0.1551
  rs7089661	Imputed	C	DOM	442	1.347	0.1964	0.9168	1.98	1.518	0.129
  rs7101319	Imputed	C	ADD	431	1.259	0.2167	0.8235	1.926	1.064	0.2873
  rs7101319	Imputed	C	DOM	431	1.425	0.2303	0.9076	2.239	1.539	0.1238
  rs710832	Genotyped	A	GEN	443					3.803	0.1494
  rs710832	Genotyped	A	REC	443	0.4518	0.4871	0.1739	1.174	−1.631	0.1029
  rs7134262	Imputed	T	GEN	438					5.456	0.06536
  rs7134262	Imputed	T	REC	438	1.986	0.3091	1.084	3.641	2.22	0.02641
  rs7134671	Imputed	T	GEN	443					1.45	0.4843
  rs7138300	Imputed	C	ADD	432	0.7137	0.1396	0.5429	0.9384	−2.415	0.01572
  rs7138300	Imputed	C	DOM	432	0.7026	0.2117	0.464	1.064	−1.667	0.09546
  rs7138300	Imputed	C	GEN	432					6.276	0.04338
  rs7163931	Imputed	G	GEN	443					2.593	0.2734
  rs7163931	Imputed	G	REC	443	1.965	0.4472	0.8177	4.72	1.51	0.1311
  rs7171486	Genotyped	G	DOM	443	0.591	0.1997	0.3996	0.8741	−2.634	0.008445
  rs7172611	Imputed	G	GEN	443					2.593	0.2734
  rs7172611	Imputed	G	REC	443	1.965	0.4472	0.8177	4.72	1.51	0.1311
  rs7172689	Imputed	T	GEN	443					2.593	0.2734
  rs7172689	Imputed	T	REC	443	1.965	0.4472	0.8177	4.72	1.51	0.1311
  rs7175701	Imputed	C	GEN	440					2.427	0.2972
  rs7180245	Imputed	A	GEN	443					2.593	0.2734
  rs7180245	Imputed	A	REC	443	1.965	0.4472	0.8177	4.72	1.51	0.1311
  rs7220603	Genotyped	A	ADD	443	1.419	0.1547	1.048	1.921	2.261	0.02374
  rs7282518	Imputed	T	ADD	387	1.054	0.205	0.7055	1.576	0.2585	0.796
  rs7283476	Imputed	T	ADD	441	0.413	0.3729	0.1989	0.8579	−2.371	0.01774
  rs7283476	Imputed	T	DOM	441	0.3545	0.3985	0.1623	0.7741	−2.602	0.009257
  rs7295817	Imputed	C	GEN	424					6.629	0.03635
  rs7298255	Imputed	A	ADD	443	0.7433	0.1356	0.5699	0.9696	−2.188	0.02869
  rs7298255	Imputed	A	DOM	443	0.74	0.2089	0.4914	1.114	−1.442	0.1493
  rs7305832	Imputed	C	GEN	442					5.607	0.06061
  rs7305832	Imputed	C	REC	442	2.008	0.3089	1.096	3.678	2.256	0.02404
  rs7331467	Imputed	A	GEN	443					1.596	0.4502
  rs7392620	Imputed	C	ADD	437	0.6521	0.1533	0.4829	0.8807	−2.789	0.005287
  rs742827	Imputed	A	ADD	437	1.396	0.145	1.051	1.855	2.3	0.02146
  rs742827	Imputed	A	GEN	437					6.499	0.03879
  rs742827	Imputed	A	REC	437	2.051	0.2943	1.152	3.652	2.441	0.01464
  rs7446891	Imputed	G	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs7448641	Imputed	C	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs7448641	Imputed	C	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs7484728	Imputed	T	GEN	443					1.45	0.4843
  rs7499402	Genotyped	A	ADD	443	2.08	0.2847	1.191	3.634	2.573	0.01008
  rs7529851	Imputed	A	ADD	401	0.7324	0.1517	0.544	0.986	−2.053	0.04006
  rs7529851	Imputed	A	GEN	401					4.232	0.1205
  rs7573951	Imputed	G	ADD	442	1.009	0.1374	0.7712	1.321	0.06836	0.9455
  rs7599198	Imputed	T	DOM	371	0.9895	0.2386	0.6199	1.579	−0.04427	0.9647
  rs7600050	Imputed	C	ADD	416	1.316	0.1481	0.9845	1.759	1.855	0.06365
  rs7607712	Imputed	T	ADD	441	1.357	0.1708	0.9708	1.897	1.787	0.074
  rs7607712	Imputed	T	DOM	441	1.496	0.2035	1.004	2.23	1.98	0.04765
  rs7613492	Imputed	G	GEN	443					0.8065	0.6682
  rs7621663	Imputed	G	ADD	443	1.048	0.1481	0.7837	1.401	0.3148	0.7529
  rs7621663	Imputed	G	GEN	443					0.8065	0.6682
  rs7621663	Imputed	G	REC	443	0.8874	0.3167	0.4771	1.651	−0.3773	0.706
  rs7626584	Imputed	G	ADD	442	0.6617	0.3179	0.3549	1.234	−1.299	0.1939
  rs7684899	Imputed	C	ADD	417	0.617	0.1957	0.4205	0.9055	−2.467	0.01361
  rs7684899	Imputed	C	DOM	417	0.5176	0.2237	0.3339	0.8024	−2.944	0.00324
  rs7701604	Imputed	G	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs7701604	Imputed	G	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs7703676	Imputed	C	ADD	443	0.9741	0.2886	0.5532	1.715	−0.09096	0.9275
  rs7703676	Imputed	C	DOM	443	1.136	0.3415	0.5817	2.218	0.3732	0.709
  rs7708491	Imputed	C	REC	435	1.179	0.2374	0.7405	1.878	0.6947	0.4872
  rs7711358	Imputed	A	DOM	443	0.593	0.2016	0.3994	0.8804	−2.592	0.009541
  rs7719448	Imputed	G	REC	436	1.235	0.2366	0.777	1.965	0.8936	0.3715
  rs7724761	Imputed	T	REC	435	1.207	0.2381	0.7571	1.925	0.791	0.429
  rs7742476	Imputed	T	DOM	386	1.23	0.2098	0.8155	1.856	0.988	0.3231
  rs7762993	Imputed	A	ADD	431	1.066	0.1948	0.7276	1.561	0.3271	0.7436
  rs7762993	Imputed	A	DOM	431	1.079	0.2057	0.7207	1.614	0.3676	0.7132
  rs7767265	Imputed	G	ADD	430	1.18	0.1729	0.8411	1.656	0.9587	0.3377
  rs7767265	Imputed	G	DOM	430	1.155	0.1977	0.7839	1.702	0.7283	0.4664
  rs7768128	Imputed	G	REC	439	0.3066	0.5174	0.1112	0.8451	−2.285	0.0223
  rs7771264	Imputed	T	DOM	441	1.051	0.1977	0.7133	1.548	0.251	0.8018
  rs7773151	Genotyped	C	DOM	443	1.038	0.1992	0.7027	1.534	0.1891	0.85
  rs7773210	Genotyped	A	DOM	443	1.038	0.1992	0.7027	1.534	0.1891	0.85
  rs7808536	Imputed	G	DOM	409	1.374	0.2138	0.904	2.09	1.488	0.1368
  rs7843510	Genotyped	G	DOM	443	0.9929	0.2031	0.6669	1.478	−0.03512	0.972
  rs7894867	Imputed	T	DOM	441	1.426	0.2276	0.9129	2.228	1.559	0.1189
  rs7921834	Imputed	C	DOM	440	1.347	0.1965	0.9164	1.98	1.516	0.1296
  rs7939893	Imputed	C	ADD	441	0.6916	0.1478	0.5177	0.924	−2.495	0.01261
  rs7939893	Imputed	C	DOM	441	0.506	0.1982	0.3431	0.7463	−3.437	0.000589
  rs7944513	Imputed	T	GEN	418					4.036	0.1329
  rs7944513	Imputed	T	REC	418	1.787	0.3844	0.8411	3.795	1.51	0.1311
  rs7949720	Imputed	G	ADD	418	1.485	0.2216	0.9616	2.292	1.783	0.07457
  rs7949720	Imputed	G	DOM	418	1.52	0.2398	0.9502	2.433	1.747	0.08065
  rs7955901	Imputed	C	ADD	440	0.7285	0.1367	0.5573	0.9524	−2.316	0.02054
  rs7955901	Imputed	C	DOM	440	0.7139	0.2105	0.4726	1.078	−1.601	0.1093
  rs7956274	Imputed	T	ADD	426	0.7156	0.1398	0.5441	0.9412	−2.394	0.01667
  rs7956274	Imputed	T	DOM	426	0.7031	0.2129	0.4633	1.067	−1.655	0.098
  rs7956274	Imputed	T	GEN	426					6.165	0.04584
  rs7957932	Imputed	G	ADD	439	0.7234	0.1368	0.5533	0.9459	−2.366	0.01797
  rs7957932	Imputed	G	DOM	439	0.6888	0.212	0.4546	1.044	−1.758	0.07871
  rs7984504	Imputed	C	GEN	443					0.4224	0.8096
  rs7999518	Imputed	A	REC	423	0.4462	0.248	0.2745	0.7255	−3.254	0.001137
  rs8026245	Imputed	G	GEN	442					2.296	0.3173
  rs8026245	Imputed	G	REC	442	1.888	0.4309	0.8114	4.394	1.475	0.1402
  rs8060725	Genotyped	A	ADD	443	0.6772	0.162	0.493	0.9303	−2.406	0.01613
  rs8103016	Genotyped	A	ADD	443	1.223	0.1622	0.8901	1.681	1.242	0.2142
  rs8103016	Genotyped	A	DOM	443	1.343	0.1996	0.9084	1.987	1.479	0.1391
  rs8104182	Imputed	G	ADD	440	1.298	0.1657	0.9382	1.796	1.575	0.1152
  rs8104182	Imputed	G	DOM	440	1.4	0.1997	0.9468	2.071	1.686	0.09175
  rs8129461	Imputed	G	ADD	441	0.3726	0.3715	0.1799	0.7717	−2.657	0.007877
  rs8129461	Imputed	G	DOM	441	0.3187	0.3953	0.1469	0.6915	−2.893	0.003814
  rs8130021	Imputed	G	ADD	442	0.4152	0.3729	0.1999	0.8624	−2.357	0.01842
  rs8130021	Imputed	G	DOM	442	0.3565	0.3985	0.1632	0.7784	−2.589	0.009634
  rs879961	Imputed	T	ADD	440	1.178	0.1585	0.8634	1.607	1.033	0.3014
  rs879961	Imputed	T	DOM	440	1.245	0.1948	0.8502	1.825	1.127	0.2598
  rs906353	Imputed	A	DOM	434	1.22	0.1967	0.8295	1.794	1.01	0.3127
  rs915491	Imputed	C	DOM	441	1.329	0.1967	0.9042	1.955	1.448	0.1476
  rs915493	Imputed	T	DOM	441	1.329	0.1967	0.9042	1.955	1.448	0.1476
  rs915494	Imputed	A	ADD	422	1.399	0.1473	1.048	1.868	2.281	0.02256
  rs915494	Imputed	A	DOM	422	1.486	0.1999	1.004	2.199	1.982	0.0475
  rs917295	Imputed	G	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs9284851	Imputed	A	GEN	436					1.977	0.3722
  rs9293464	Imputed	T	REC	435	1.207	0.2381	0.7571	1.925	0.791	0.429
  rs9295154	Genotyped	G	DOM	443	1.463	0.2215	0.9479	2.259	1.719	0.08569
  rs9310221	Imputed	A	DOM	393	0.8966	0.2237	0.5784	1.39	−0.4881	0.6255
  rs9310699	Genotyped	T	GEN	443					0.308	0.8573
  rs9310700	Imputed	C	ADD	443	1.048	0.1481	0.7837	1.401	0.3148	0.7529
  rs9310700	Imputed	C	GEN	443					0.8065	0.6682
  rs9310701	Imputed	G	GEN	443					1.33	0.5142
  rs9310704	Imputed	G	GEN	436					1.977	0.3722
  rs9319185	Imputed	C	GEN	441					0.9349	0.6266
  rs9319186	Imputed	T	GEN	443					0.4224	0.8096
  rs9327555	Imputed	T	DOM	443	0.5934	0.2016	0.3997	0.881	−2.589	0.009637
  rs9403367	Imputed	C	DOM	443	1.038	0.1992	0.7027	1.534	0.1891	0.85
  rs9419608	Imputed	G	REC	430	0.5885	0.2576	0.3552	0.9749	−2.059	0.03953
  rs9426437	Imputed	T	DOM	424	1.067	0.2164	0.6984	1.631	0.3009	0.7635
  rs9454967	Imputed	G	DOM	441	0.9744	0.2621	0.583	1.629	−0.09893	0.9212
  rs9635511	Imputed	T	DOM	436	0.8692	0.2057	0.5809	1.301	−0.6814	0.4956
  rs966583	Imputed	A	ADD	439	0.7596	0.1431	0.5738	1.005	−1.922	0.05464
  rs966583	Imputed	A	DOM	439	0.6781	0.203	0.4555	1.01	−1.913	0.0557
  rs980263	Imputed	T	GEN	443					1.33	0.5142
  rs980264	Imputed	T	GEN	443					1.33	0.5142
  rs9812206	Imputed	G	ADD	442	1.042	0.2668	0.6177	1.758	0.1545	0.8772
  rs9812206	Imputed	G	DOM	442	1.042	0.2668	0.6177	1.758	0.1545	0.8772
  rs9813552	Imputed	G	ADD	442	1.042	0.2623	0.6235	1.743	0.1586	0.874
  rs9813552	Imputed	G	DOM	442	1.077	0.2681	0.6368	1.821	0.2766	0.7821
  rs9815037	Imputed	T	ADD	443	1.048	0.2622	0.6267	1.752	0.1778	0.8589
  rs9815037	Imputed	T	DOM	443	1.083	0.2681	0.6401	1.831	0.2958	0.7674
  rs9819583	Imputed	T	GEN	443					0.308	0.8573
  rs9825349	Imputed	A	ADD	443	1.048	0.2622	0.6267	1.752	0.1778	0.8589
  rs9825349	Imputed	A	DOM	443	1.083	0.2681	0.6401	1.831	0.2958	0.7674
  rs9833118	Imputed	G	ADD	443	1.048	0.1481	0.7837	1.401	0.3148	0.7529
  rs9833118	Imputed	G	GEN	443					0.8065	0.6682
  rs9834217	Imputed	T	ADD	443	1.017	0.2611	0.6096	1.696	0.06425	0.9488
  rs9834217	Imputed	T	DOM	443	1.049	0.2668	0.6218	1.77	0.179	0.858
  rs9838563	Imputed	C	GEN	437					1.084	0.5817
  rs9840460	Imputed	T	ADD	443	1.017	0.2611	0.6096	1.696	0.06425	0.9488
  rs9840460	Imputed	T	DOM	443	1.049	0.2668	0.6218	1.77	0.179	0.858
  rs9840756	Imputed	A	ADD	437	0.9995	0.2614	0.5988	1.668	−0.00192	0.9985
  rs9840756	Imputed	A	DOM	437	1.031	0.2671	0.6105	1.74	0.1127	0.9103
  rs9847999	Imputed	C	GEN	436					1.977	0.3722
  rs9864769	Imputed	C	GEN	443					1.33	0.5142
  rs9866421	Genotyped	C	REC	443	0.5895	0.2541	0.3583	0.9701	−2.08	0.03756
  rs987296	Imputed	T	GEN	441					0.3297	0.848
  rs9881685	Imputed	A	ADD	440	1.041	0.2668	0.6172	1.756	0.151	0.88
  rs9881685	Imputed	A	DOM	440	1.041	0.2668	0.6172	1.756	0.151	0.88
  rs992695	Imputed	C	ADD	442	1.16	0.158	0.8507	1.581	0.9366	0.3489
  rs992695	Imputed	C	DOM	442	1.216	0.194	0.8313	1.778	1.008	0.3136
  rs9936999	Imputed	G	DOM	266	0.7758	0.254	0.4716	1.276	−0.9992	0.3177
  			ATORVA_	PRAVA_	ATORVA_	ATORVA_	ATORVA_	PRAVA_	PRAVA_	PRAVA_
  	HW_	ALLELE_	ALLELE_	ALLELE_	HZ_	HET_	A2_HZ_	A1_HZ_	HET_	A2_HZ_
  SNP rs #	PVALUE	FREQ	FREQ	FREQ	COUNT	COUNT	COUNT	COUNT	COUNT	COUNT
  rs77638540	0.3489	0.05305	0.0314	0.0694	1	10	180	1	33	218
  rs72746987	1	0.04176	0.0419	0.0417	0	16	175	0	21	231
  rs10021016	0.7144	0.26298	0.2984	0.2361	20	74	97	12	95	145
  rs10021016	0.7144	0.26298	0.2984	0.2361	20	74	97	12	95	145
  rs10051148	0.8242	0.30813	0.2801	0.3294	20	67	104	23	120	109
  rs10054055	0.3313	0.32841	0.2937	0.3546	23	65	101	29	120	102
  rs10067895	0.07522	0.34886	0.3132	0.376	27	65	98	35	118	97
  rs10100725	0.3323	0.17833	0.1859	0.1726	9	53	129	8	71	173
  rs10128531	0.677	0.13735	0.1742	0.1097	6	50	122	3	46	188
  rs10181743	0.6902	0.43046	0.4469	0.4181	35	90	54	40	119	79
  rs10199127	0.3263	0.32831	0.3155	0.3381	17	84	86	34	97	113
  rs10270624	0.7448	0.18582	0.2095	0.1674	8	59	112	7	63	160
  rs1030006	0.7002	0.47005	0.4599	0.4777	40	92	55	58	120	69
  rs1031811	0.7388	0.31567	0.361	0.2814	29	77	81	16	107	124
  rs10430870	0.7024	0.24831	0.2853	0.2202	20	69	102	9	93	150
  rs10430870	0.7024	0.24831	0.2853	0.2202	20	69	102	9	93	150
  rs10469597	0.5359	0.27494	0.2599	0.2863	13	66	98	15	104	115
  rs10469597	0.5359	0.27494	0.2599	0.2863	13	66	98	15	104	115
  rs10478919	0.1134	0.34312	0.3089	0.369	26	66	99	34	118	100
  rs10506623	0.6908	0.3948	0.3632	0.4187	26	86	78	45	121	86
  rs10506623	0.6908	0.3948	0.3632	0.4187	26	86	78	45	121	86
  rs10506626	0.5504	0.39391	0.356	0.4226	26	84	81	46	121	85
  rs10506626	0.5504	0.39391	0.356	0.4226	26	84	81	46	121	85
  rs10509477	0.1655	0.33409	0.3691	0.3075	29	83	79	27	101	124
  rs10517918	0.4917	0.42725	0.4309	0.4245	32	98	58	43	122	80
  rs10517924	1	0.46154	0.466	0.4582	42	94	55	52	126	73
  rs10519362	0.5877	0.15668	0.1882	0.1331	6	58	122	6	54	188
  rs10520072	0.1134	0.34312	0.3115	0.3671	27	65	99	33	119	100
  rs10737390	0.3626	0.40909	0.419	0.4017	30	90	59	35	122	82
  rs10742851	0.4903	0.29007	0.3037	0.2798	18	80	93	16	109	127
  rs10743685	0.1663	0.41379	0.4335	0.3988	34	95	59	33	131	83
  rs10743685	0.1663	0.41379	0.4335	0.3988	34	95	59	33	131	83
  rs10749293	0.1901	0.322	0.3579	0.2948	26	84	80	26	96	129
  rs10749294	0.2987	0.29007	0.3246	0.2639	23	78	90	19	95	138
  rs10753760	0.01675	0.41844	0.4108	0.4244	36	80	69	50	102	86
  rs10753760	0.01675	0.41844	0.4108	0.4244	36	80	69	50	102	86
  rs10772362	0.5807	0.22122	0.2068	0.2321	7	65	119	12	93	147
  rs10784891	0.4305	0.4455	0.4049	0.4769	30	89	65	58	111	69
  rs10784891	0.4305	0.4455	0.4049	0.4769	30	89	65	58	111	69
  rs10784891	0.4305	0.4455	0.4049	0.4769	30	89	65	58	111	69
  rs10787923	0.1572	0.32232	0.359	0.2948	26	83	79	26	96	129
  rs10787924	0.2987	0.29007	0.3246	0.2639	23	78	90	19	95	138
  rs10787949	0.1377	0.33937	0.3717	0.3147	29	84	78	29	100	122
  rs10787951	0.1364	0.339	0.3711	0.3147	29	83	78	29	100	122
  rs10787983	0.1642	0.33447	0.3691	0.308	29	83	79	27	100	123
  rs10794733	0.578	0.31093	0.2605	0.3494	13	73	104	32	110	107
  rs10818280	0.347	0.28588	0.2433	0.3184	10	71	106	21	114	110
  rs10860586	0.9232	0.5058	0.4892	0.5183	44	93	48	67	121	58
  rs10860586	0.9232	0.5058	0.4892	0.5183	44	93	48	67	121	58
  rs10870473	1	0.29944	0.3209	0.2864	4	35	28	12	39	59
  rs10870473	1	0.29944	0.3209	0.2864	4	35	28	12	39	59
  rs10879240	0.434	0.44743	0.4043	0.4813	30	92	66	60	111	69
  rs10879240	0.434	0.44743	0.4043	0.4813	30	92	66	60	111	69
  rs10879242	0.9197	0.40855	0.373	0.4364	26	86	73	45	116	75
  rs10879242	0.9197	0.40855	0.373	0.4364	26	86	73	45	116	75
  rs10879245	0.9197	0.40855	0.373	0.4364	26	86	73	45	116	75
  rs10879245	0.9197	0.40855	0.373	0.4364	26	86	73	45	116	75
  rs10879249	0.7662	0.39773	0.3658	0.422	26	87	77	45	121	84
  rs10879249	0.7662	0.39773	0.3658	0.422	26	87	77	45	121	84
  rs10886429	0.1642	0.33447	0.3665	0.31	29	82	80	27	101	122
  rs10886449	0.1168	0.30795	0.3474	0.278	28	76	86	21	97	132
  rs10886451	0.1168	0.30795	0.3474	0.278	28	76	86	21	97	132
  rs10886452	0.1648	0.33523	0.3737	0.306	30	82	78	26	101	123
  rs10886456	0.1168	0.30795	0.3474	0.278	28	76	86	21	97	132
  rs10886463	0.1118	0.3405	0.3743	0.3147	30	83	78	29	100	122
  rs10886465	0.1364	0.339	0.3743	0.312	30	83	78	28	100	122
  rs10886526	0.2383	0.33257	0.3677	0.306	28	83	78	26	101	123
  rs10922903	0.8458	0.43068	0.4418	0.4223	34	99	56	46	120	85
  rs10941126	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs10941126	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs10947980	0.4609	0.2631	0.2632	0.2631	10	80	100	17	97	135
  rs11059376	1	0.16459	0.1695	0.1608	3	53	118	8	57	162
  rs11072995	0.295	0.19932	0.2237	0.1807	13	59	118	8	74	167
  rs11072995	0.295	0.19932	0.2237	0.1807	13	59	118	8	74	167
  rs11081202	0.456	0.25621	0.288	0.2321	22	66	103	10	97	145
  rs11081202	0.456	0.25621	0.288	0.2321	22	66	103	10	97	145
  rs110965	0.9143	0.34643	0.3984	0.3067	34	77	71	17	112	109
  rs11124962	0.3787	0.25515	0.2632	0.249	11	78	101	21	81	145
  rs1116596	0.1134	0.34312	0.3089	0.369	26	66	99	34	118	100
  rs11178531	0.3881	0.46811	0.4211	0.504	34	92	64	67	117	65
  rs11178531	0.3881	0.46811	0.4211	0.504	34	92	64	67	117	65
  rs11178583	0.6922	0.39503	0.3639	0.4187	26	87	78	45	121	86
  rs11178583	0.6922	0.39503	0.3639	0.4187	26	87	78	45	121	86
  rs11178589	0.8419	0.39931	0.3658	0.4251	26	87	77	45	120	82
  rs11178589	0.8419	0.39931	0.3658	0.4251	26	87	77	45	120	82
  rs11178594	1	0.40249	0.3684	0.4283	26	88	76	45	125	81
  rs11178594	1	0.40249	0.3684	0.4283	26	88	76	45	125	81
  rs11178602	1	0.40205	0.3677	0.428	26	87	76	45	124	81
  rs11178602	1	0.40205	0.3677	0.428	26	87	76	45	124	81
  rs11178648	0.4852	0.39432	0.3571	0.4223	26	83	80	46	120	85
  rs11178648	0.4852	0.39432	0.3571	0.4223	26	83	80	46	120	85
  rs11198877	0.1996	0.3356	0.3737	0.3068	30	82	78	26	102	123
  rs11198942	0.1655	0.33409	0.3691	0.3075	29	83	79	27	101	124
  rs11221075	1	0.11391	0.0754	0.1429	0	27	152	5	58	175
  rs11242020	0.1134	0.34312	0.3089	0.369	26	66	99	34	118	100
  rs11242021	0.1134	0.34312	0.3115	0.3671	27	65	99	33	119	100
  rs11242022	0.1134	0.34312	0.3115	0.3671	27	65	99	33	119	100
  rs11242023	0.1134	0.34312	0.3115	0.3671	27	65	99	33	119	100
  rs1149349	0.4627	0.15323	0.1508	0.1551	1	55	133	11	54	180
  rs1149350	0.01047	0.21445	0.1885	0.2341	6	60	125	24	70	158
  rs1149350	0.01047	0.21445	0.1885	0.2341	6	60	125	24	70	158
  rs11576627	0.01289	0.12358	0.15	0.1036	7	43	140	6	40	205
  rs11576627	0.01289	0.12358	0.15	0.1036	7	43	140	6	40	205
  rs11630050	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs11630050	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs11633024	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs11633024	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs11636298	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs11636298	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs11637363	0.7866	0.23452	0.2527	0.2203	14	65	105	10	84	142
  rs11637363	0.7866	0.23452	0.2527	0.2203	14	65	105	10	84	142
  rs11637813	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs11637813	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs11638043	0.7866	0.23452	0.2527	0.2203	14	65	105	10	84	142
  rs11638043	0.7866	0.23452	0.2527	0.2203	14	65	105	10	84	142
  rs11638115	0.295	0.19932	0.2237	0.1807	13	59	118	8	74	167
  rs11638115	0.295	0.19932	0.2237	0.1807	13	59	118	8	74	167
  rs11638444	0.4848	0.21606	0.2368	0.2004	13	64	113	10	81	161
  rs11682946	1	0.09884	0.15	0.0543	0	12	28	0	5	41
  rs11682946	1	0.09884	0.15	0.0543	0	12	28	0	5	41
  rs11717157	0.662	0.319	0.3246	0.3147	19	86	86	28	102	121
  rs11717157	0.662	0.319	0.3246	0.3147	19	86	86	28	102	121
  rs11724055	0.6032	0.16253	0.1283	0.1885	6	37	148	7	81	164
  rs11743355	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs11743355	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs11746806	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs11746806	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs11746959	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs11746959	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs11749272	0.1134	0.34312	0.3089	0.369	26	66	99	34	118	100
  rs11839636	0.4378	0.31293	0.2989	0.3234	17	79	93	30	103	119
  rs11839785	0.4378	0.31293	0.2989	0.3234	17	79	93	30	103	119
  rs11853619	0.5684	0.2125	0.2342	0.196	13	63	114	9	80	161
  rs11853619	0.5684	0.2125	0.2342	0.196	13	63	114	9	80	161
  rs11856780	0.5684	0.2125	0.2342	0.196	13	63	114	9	80	161
  rs11856780	0.5684	0.2125	0.2342	0.196	13	63	114	9	80	161
  rs11901899	0.3322	0.27582	0.3071	0.2521	14	85	85	14	94	134
  rs11903290	0.7388	0.31567	0.361	0.2814	29	77	81	16	107	124
  rs11909480	0.2386	0.0467	0.0263	0.0622	1	8	181	1	29	219
  rs11909480	0.2386	0.0467	0.0263	0.0622	1	8	181	1	29	219
  rs11910289	0.1085	0.08409	0.1099	0.0643	4	34	153	2	28	219
  rs11910289	0.1085	0.08409	0.1099	0.0643	4	34	153	2	28	219
  rs11920375	0.8294	0.32844	0.3351	0.3234	19	90	82	30	103	119
  rs11926319	0.4982	0.07675	0.0759	0.0774	0	29	162	1	37	214
  rs11933744	0.3677	0.30455	0.2804	0.3227	18	70	101	27	108	116
  rs11934919	0.4994	0.30159	0.2778	0.3194	17	71	101	26	109	117
  rs11934957	0.4994	0.30159	0.2778	0.3194	17	71	101	26	109	117
  rs11959206	0.923	0.45853	0.4545	0.4615	43	84	60	49	130	68
  rs12038613	0.9202	0.44678	0.4483	0.4457	33	90	51	47	111	72
  rs12151417	0.8879	0.21493	0.2435	0.1932	9	75	107	12	73	166
  rs12153185	0.07489	0.35034	0.3132	0.3785	27	65	98	36	118	97
  rs12182651	0.07328	0.0907	0.0895	0.0916	3	28	159	4	38	209
  rs12235345	0.3489	0.05305	0.0707	0.0397	2	23	166	0	20	232
  rs12324786	0.295	0.19932	0.2237	0.1807	13	59	118	8	74	167
  rs12324786	0.295	0.19932	0.2237	0.1807	13	59	118	8	74	167
  rs12336958	0.9166	0.38452	0.3621	0.4013	23	80	71	38	111	84
  rs12407412	0.01289	0.12358	0.15	0.1036	7	43	140	6	40	205
  rs12407412	0.01289	0.12358	0.15	0.1036	7	43	140	6	40	205
  rs12418971	0.6068	0.24771	0.2884	0.2166	20	69	100	9	89	149
  rs12418971	0.6068	0.24771	0.2884	0.2166	20	69	100	9	89	149
  rs1241967	0.6028	0.35214	0.3429	0.3591	18	95	78	34	113	105
  rs12420184	1	0.14954	0.1693	0.1345	4	56	129	5	57	187
  rs12433968	0.0315	0.31623	0.3197	0.3136	14	89	80	18	112	106
  rs12445477	0.3613	0.08899	0.0788	0.0967	3	23	158	2	43	198
  rs12447191	0.8583	0.15801	0.1387	0.1726	5	43	143	5	77	170
  rs12447191	0.8583	0.15801	0.1387	0.1726	5	43	143	5	77	170
  rs12465349	0.8461	0.55069	0.5775	0.5304	69	78	40	61	140	46
  rs1247340	0.0397	0.20522	0.1789	0.2251	4	60	126	22	69	160
  rs1247340	0.0397	0.20522	0.1789	0.2251	4	60	126	22	69	160
  rs1247341	0.05636	0.20408	0.1806	0.222	4	61	126	21	69	160
  rs1247341	0.05636	0.20408	0.1806	0.222	4	61	126	21	69	160
  rs1247343	0.03783	0.1644	0.15	0.1753	1	55	134	17	54	180
  rs12509758	0.1442	0.20757	0.2193	0.1988	7	68	112	17	65	167
  rs12515472	0.8546	0.1535	0.1937	0.123	6	62	123	5	52	195
  rs12548906	1	0.19639	0.2458	0.1597	10	67	100	6	64	168
  rs12596240	0.9223	0.41986	0.3953	0.4385	26	99	66	51	119	82
  rs12618781	0.8483	0.47045	0.4709	0.4701	40	98	51	56	124	71
  rs12678600	1	0.31663	0.2989	0.33	18	77	94	26	113	111
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  rs6789091	1	0.34633	0.3537	0.3407	20	93	75	32	105	111
  rs6791296	0.08628	0.13146	0.1056	0.1504	1	36	143	2	70	174
  rs6792662	0.00046	0.55069	0.5829	0.5263	70	78	39	80	100	67
  rs6797574	1	0.34633	0.3537	0.3407	20	93	75	32	105	111
  rs6797882	1	0.34633	0.3537	0.3407	20	93	75	32	105	111
  rs6805139	0.00028	0.52941	0.5628	0.504	67	81	43	76	101	74
  rs6806043	0.6626	0.31973	0.3246	0.316	19	86	86	28	102	120
  rs6806043	0.6626	0.31973	0.3246	0.316	19	86	86	28	102	120
  rs6850716	0.8929	0.22912	0.2094	0.244	9	62	120	15	93	144
  rs6867153	0.923	0.45853	0.4545	0.4615	43	84	60	49	130	68
  rs687047	0.8186	0.11512	0.0838	0.1389	0	32	159	5	60	187
  rs6871041	0.6303	0.2823	0.2582	0.3008	16	62	104	15	112	109
  rs688358	0.8183	0.1171	0.086	0.1411	0	32	154	5	58	178
  rs6888012	0.9228	0.45949	0.457	0.4614	43	84	59	49	129	68
  rs6908481	0.7579	0.41875	0.4327	0.4083	35	78	58	37	113	79
  rs7032231	0.09405	0.32033	0.3736	0.2801	31	74	77	20	95	126
  rs7067638	0.1751	0.11991	0.1342	0.1091	0	51	139	3	49	200
  rs7077799	0.1663	0.33484	0.3691	0.3088	29	83	79	27	101	123
  rs7082163	0.49	0.11818	0.1303	0.1091	0	49	139	4	47	201
  rs7082163	0.49	0.11818	0.1303	0.1091	0	49	139	4	47	201
  rs7089661	0.3355	0.33145	0.3665	0.3048	28	84	79	25	103	123
  rs7101319	0.3713	0.12065	0.1344	0.1102	0	50	136	4	46	195
  rs7101319	0.3713	0.12065	0.1344	0.1102	0	50	136	4	46	195
  rs710832	0.4404	0.24492	0.2147	0.2679	6	70	115	17	101	134
  rs710832	0.4404	0.24492	0.2147	0.2679	6	70	115	17	101	134
  rs7134262	1	0.3379	0.3763	0.3085	29	85	76	21	111	116
  rs7134262	1	0.3379	0.3763	0.3085	29	85	76	21	111	116
  rs7134671	1	0.38939	0.4058	0.377	29	97	65	38	114	100
  rs7138300	0.438	0.4537	0.4054	0.4899	30	90	65	63	116	68
  rs7138300	0.438	0.4537	0.4054	0.4899	30	90	65	63	116	68
  rs7138300	0.438	0.4537	0.4054	0.4899	30	90	65	63	116	68
  rs7163931	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7163931	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7171486	0.7558	0.35553	0.2984	0.3988	15	84	92	39	123	90
  rs7172611	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7172611	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7172689	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7172689	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7175701	1	0.23409	0.254	0.2191	14	68	107	10	90	151
  rs7180245	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7180245	0.5733	0.21332	0.2356	0.1964	13	64	114	9	81	162
  rs7220603	0.3685	0.30135	0.3403	0.2718	19	92	80	17	103	132
  rs7282518	0.7019	0.15504	0.1605	0.1511	3	46	113	5	58	162
  rs7283476	0.237	0.04649	0.0262	0.062	1	8	182	1	29	220
  rs7283476	0.237	0.04649	0.0262	0.062	1	8	182	1	29	220
  rs7295817	1	0.42807	0.3819	0.4628	23	93	66	55	114	73
  rs7298255	0.2143	0.46163	0.4188	0.494	34	92	65	67	115	70
  rs7298255	0.2143	0.46163	0.4188	0.494	34	92	65	67	115	70
  rs7305832	1	0.33597	0.3743	0.3068	29	85	77	21	112	118
  rs7305832	1	0.33597	0.3743	0.3068	29	85	77	21	112	118
  rs7331467	1	0.34876	0.3325	0.3611	19	89	83	35	112	105
  rs7392620	0.7378	0.31121	0.2593	0.3508	12	74	103	32	110	106
  rs742827	0.4608	0.34668	0.3895	0.3138	33	82	75	23	109	115
  rs742827	0.4608	0.34668	0.3895	0.3138	33	82	75	23	109	115
  rs742827	0.4608	0.34668	0.3895	0.3138	33	82	75	23	109	115
  rs7446891	0.1134	0.34312	0.3115	0.3671	27	65	99	33	119	100
  rs7448641	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs7448641	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs7484728	1	0.38939	0.4058	0.377	29	97	65	38	114	100
  rs7499402	1	0.06546	0.089	0.0476	0	34	157	1	22	229
  rs7529851	0.3514	0.40648	0.3571	0.4421	22	76	70	49	108	76
  rs7529851	0.3514	0.40648	0.3571	0.4421	22	76	70	49	108	76
  rs7573951	0.2878	0.43891	0.4398	0.4382	36	96	59	55	110	86
  rs7599198	0.1175	0.46092	0.4565	0.4643	30	87	44	41	113	56
  rs7600050	0.9138	0.34736	0.3812	0.3213	27	84	70	24	103	108
  rs7607712	0.6555	0.19955	0.2277	0.178	9	69	113	10	69	171
  rs7607712	0.6555	0.19955	0.2277	0.178	9	69	113	10	69	171
  rs7613492	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs7621663	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs7621663	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs7621663	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs7626584	1	0.05769	0.0471	0.0657	0	18	173	1	31	219
  rs7684899	0.8637	0.17266	0.1346	0.2021	6	37	139	7	81	147
  rs7684899	0.8637	0.17266	0.1346	0.2021	6	37	139	7	81	147
  rs7701604	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs7701604	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs7703676	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs7703676	2.36E−05	0.07336	0.0733	0.0734	3	22	166	7	23	222
  rs7708491	0.8472	0.45977	0.4545	0.4637	43	84	60	50	130	68
  rs7711358	0.1134	0.34312	0.3089	0.369	26	66	99	34	118	100
  rs7719448	0.847	0.45872	0.4574	0.4597	44	84	60	49	130	69
  rs7724761	0.9232	0.45862	0.4545	0.4617	43	84	60	49	131	68
  rs7742476	0.00424	0.23316	0.2544	0.2166	7	72	90	4	86	127
  rs7762993	0.00187	0.18213	0.1855	0.1796	2	65	119	3	82	160
  rs7762993	0.00187	0.18213	0.1855	0.1796	2	65	119	3	82	160
  rs7767265	0.0128	0.24419	0.2594	0.2325	9	79	99	7	99	137
  rs7767265	0.0128	0.24419	0.2594	0.2325	9	79	99	7	99	137
  rs7768128	0.7859	0.22779	0.2275	0.228	5	76	108	19	76	155
  rs7771264	0.25	0.2483	0.2513	0.246	14	67	108	18	88	146
  rs7773151	0.3391	0.2246	0.2225	0.2262	10	65	116	16	82	154
  rs7773210	0.3391	0.2246	0.2225	0.2262	10	65	116	16	82	154
  rs7808536	0.7448	0.18582	0.2095	0.1674	8	59	112	7	63	160
  rs7843510	0.1444	0.42325	0.4293	0.4187	40	84	67	47	117	88
  rs7894867	0.1751	0.12018	0.1349	0.1091	0	51	138	3	49	200
  rs7921834	0.2375	0.33182	0.3658	0.306	28	83	79	26	101	123
  rs7939893	0.3875	0.32653	0.2789	0.3625	22	62	106	29	124	98
  rs7939893	0.3875	0.32653	0.2789	0.3625	22	62	106	29	124	98
  rs7944513	0.145	0.24522	0.2793	0.2197	17	66	96	14	77	148
  rs7944513	0.145	0.24522	0.2793	0.2197	17	66	96	14	77	148
  rs7949720	1	0.11603	0.1378	0.0987	3	45	137	2	42	189
  rs7949720	1	0.11603	0.1378	0.0987	3	45	137	2	42	189
  rs7955901	0.2142	0.46364	0.4184	0.498	34	91	65	67	115	68
  rs7955901	0.2142	0.46364	0.4184	0.498	34	91	65	67	115	68
  rs7956274	0.3288	0.45423	0.4066	0.4898	30	88	64	63	113	68
  rs7956274	0.3288	0.45423	0.4066	0.4898	30	88	64	63	113	68
  rs7956274	0.3288	0.45423	0.4066	0.4898	30	88	64	63	113	68
  rs7957932	0.3884	0.47039	0.4241	0.506	35	92	64	67	117	64
  rs7957932	0.3884	0.47039	0.4241	0.506	35	92	64	67	117	64
  rs7984504	0.3222	0.31603	0.3063	0.3234	19	79	93	30	103	119
  rs7999518	0.6979	0.49882	0.4385	0.543	29	99	51	74	117	53
  rs8026245	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs8026245	1	0.23416	0.2539	0.2191	14	69	108	10	90	151
  rs8060725	0.8062	0.26298	0.2225	0.2937	11	63	117	18	112	122
  rs8103016	0.4981	0.22573	0.2461	0.2103	11	72	108	14	78	160
  rs8103016	0.4981	0.22573	0.2461	0.2103	11	72	108	14	78	160
  rs8104182	0.8882	0.21591	0.2407	0.1972	10	71	108	11	77	163
  rs8104182	0.8882	0.21591	0.2407	0.1972	10	71	108	11	77	163
  rs8129461	0.2921	0.04989	0.0262	0.068	1	8	182	1	32	217
  rs8129461	0.2921	0.04989	0.0262	0.068	1	8	182	1	32	217
  rs8130021	0.2362	0.04638	0.0262	0.0618	1	8	182	1	29	221
  rs8130021	0.2362	0.04638	0.0262	0.0618	1	8	182	1	29	221
  rs879961	0.1949	0.28182	0.2974	0.27	13	87	90	16	103	131
  rs879961	0.1949	0.28182	0.2974	0.27	13	87	90	16	103	131
  rs906353	0.651	0.3053	0.3172	0.2964	16	86	84	22	103	123
  rs915491	0.1184	0.30839	0.3474	0.2789	28	76	86	21	98	132
  rs915493	0.1184	0.30839	0.3474	0.2789	28	76	86	21	98	132
  rs915494	0.1185	0.32227	0.3683	0.286	29	79	78	22	91	123
  rs915494	0.1185	0.32227	0.3683	0.286	29	79	78	22	91	123
  rs917295	0.1134	0.34312	0.3115	0.3671	27	65	99	33	119	100
  rs9284851	1	0.34633	0.3537	0.3407	20	93	75	32	105	111
  rs9293464	0.9232	0.45862	0.4545	0.4617	43	84	60	49	131	68
  rs9295154	0.2326	0.13995	0.1545	0.129	3	53	135	9	47	196
  rs9310221	0.1503	0.42875	0.426	0.4308	29	86	54	36	121	67
  rs9310699	0.5114	0.31828	0.322	0.3155	20	83	88	28	103	121
  rs9310700	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs9310700	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs9310701	0.9151	0.33409	0.3429	0.3274	20	91	80	30	105	117
  rs9310704	1	0.34633	0.3537	0.3407	20	93	75	32	105	111
  rs9319185	0.4378	0.31293	0.2989	0.3234	17	79	93	30	103	119
  rs9319186	0.3222	0.31603	0.3063	0.3234	19	79	93	30	103	119
  rs9327555	0.1134	0.34312	0.3115	0.3671	27	65	99	33	119	100
  rs9403367	0.3391	0.2246	0.2225	0.2262	10	65	116	16	82	154
  rs9419608	0.3324	0.45814	0.4098	0.4939	28	94	61	57	130	60
  rs9426437	0.3217	0.43042	0.4355	0.4265	33	96	57	40	123	75
  rs9454967	0.07328	0.0907	0.0895	0.0916	3	28	159	4	38	209
  rs9635511	0.7678	0.41399	0.3915	0.4312	26	96	67	47	119	81
  rs966583	1	0.40091	0.3658	0.4277	26	87	77	44	125	80
  rs966583	1	0.40091	0.3658	0.4277	26	87	77	44	125	80
  rs980263	0.9151	0.33409	0.3429	0.3274	20	91	80	30	105	117
  rs980264	0.9151	0.33409	0.3429	0.3274	20	91	80	30	105	117
  rs9812206	0.09556	0.07692	0.0785	0.0757	0	30	161	0	38	213
  rs9812206	0.09556	0.07692	0.0785	0.0757	0	30	161	0	38	213
  rs9813552	0.4984	0.07692	0.0785	0.0757	0	30	161	1	36	214
  rs9813552	0.4984	0.07692	0.0785	0.0757	0	30	161	1	36	214
  rs9815037	0.4982	0.07675	0.0785	0.0754	0	30	161	1	36	215
  rs9815037	0.4982	0.07675	0.0785	0.0754	0	30	161	1	36	215
  rs9819583	0.5114	0.31828	0.322	0.3155	20	83	88	28	103	121
  rs9825349	0.4982	0.07675	0.0785	0.0754	0	30	161	1	36	215
  rs9825349	0.4982	0.07675	0.0785	0.0754	0	30	161	1	36	215
  rs9833118	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs9833118	0.7429	0.31941	0.3246	0.3155	19	86	86	28	103	121
  rs9834217	0.5011	0.07788	0.0785	0.0774	0	30	161	1	37	214
  rs9834217	0.5011	0.07788	0.0785	0.0774	0	30	161	1	37	214
  rs9838563	1	0.33066	0.3413	0.3226	20	89	80	28	104	116
  rs9840460	0.5011	0.07788	0.0785	0.0774	0	30	161	1	37	214
  rs9840460	0.5011	0.07788	0.0785	0.0774	0	30	161	1	37	214
  rs9840756	0.5026	0.07895	0.0789	0.0789	0	30	160	1	37	209
  rs9840756	0.5026	0.07895	0.0789	0.0789	0	30	160	1	37	209
  rs9847999	1	0.34633	0.3537	0.3407	20	93	75	32	105	111
  rs9864769	0.9151	0.33409	0.3429	0.3274	20	91	80	30	105	117
  rs9866421	0.2848	0.42551	0.3979	0.4464	29	94	68	57	111	84
  rs987296	0.5103	0.31859	0.322	0.316	20	83	88	28	102	120
  rs9881685	0.09541	0.07727	0.0789	0.076	0	30	160	0	38	212
  rs9881685	0.09541	0.07727	0.0789	0.076	0	30	160	0	38	212
  rs992695	0.1596	0.28281	0.2974	0.2718	13	87	90	16	105	131
  rs992695	0.1596	0.28281	0.2974	0.2718	13	87	90	16	105	131
  rs9936999	0.2862	0.35714	0.3571	0.3571	20	40	52	18	74	62

• TABLE 17
  SNP rs #	SOURCE	ALLELE (A1)	MODEL	P	P(R)	OR	OR(R)	Q	I

  rs77638540	Genotyped	T	DOMINANT	2.65E−03	0.0159	0.4686	0.4785	0.2317	30.09
  rs72746987	Genotyped	A	DOMINANT	3.12E−05	3.12E−05	0.337	0.337	0.9734	0
  rs10021016	Genotyped	G	GENOTYPIC	4.88E−04	0.000488	2.3201	2.3201	0.9885	0
  rs10021016	Genotyped	G	RECESSIVE	7.69E−04	0.0007685	2.2102	2.2102	0.9334	0
  rs10051148	Imputed	C	DOMINANT	0.000697	0.000697	0.6715	0.6715	0.7678	0
  rs10054055	Imputed	T	DOMINANT	0.0008519	0.0008519	0.6758	0.6758	0.8098	0
  rs10067895	Imputed	A	DOMINANT	9.99E−04	0.0009994	0.6775	0.6775	0.9204	0
  rs10100725	Imputed	C	DOMINANT	5.54E−05	5.54E−05	0.5929	0.5929	0.3989	0
  rs10128531	Imputed	T	ADDITIVE	1.54E−03	0.001541	1.4677	1.4677	0.921	0
  rs10181743	Imputed	G	ADDITIVE	9.76E−05	9.76E−05	1.4004	1.4004	0.3524	0
  rs10199127	Imputed	T	DOMINANT	4.59E−05	4.59E−05	1.6169	1.6169	0.3286	0
  rs10270624	Imputed	G	DOMINANT	2.16E−04	0.0003017	1.5776	1.5804	0.3061	4.53
  rs1030006	Imputed	G	RECESSIVE	7.93E−05	7.93E−05	1.7557	1.7557	0.577	0
  rs1031811	Imputed	A	RECESSIVE	6.16E−03	0.006159	1.7624	1.7624	0.7766	0
  rs10430870	Genotyped	G	GENOTYPIC	3.07E−03	3.07E−03	2.094	2.094	0.4823	0
  rs10430870	Genotyped	G	RECESSIVE	0.003991	0.003991	2.0223	2.0223	0.6273	0
  rs10469597	Imputed	A	GENOTYPIC	4.70E−05	4.70E−05	2.5398	2.5398	0.9742	0
  rs10469597	Imputed	A	RECESSIVE	4.85E−05	4.85E−05	2.4663	2.4663	0.8923	0
  rs10478919	Imputed	G	DOMINANT	5.77E−04	0.0005772	0.6679	0.6679	0.7414	0
  rs10506623	Imputed	C	ADDITIVE	0.0001433	0.0001433	0.7177	0.7177	0.7038	0
  rs10506623	Imputed	C	DOMINANT	8.28E−05	8.28E−05	0.6159	0.6159	0.9559	0
  rs10506626	Imputed	A	ADDITIVE	7.58E−05	7.58E−05	0.7112	0.7112	0.422	0
  rs10506626	Imputed	A	DOMINANT	8.52E−06	8.52E−06	0.5838	0.5838	0.8702	0
  rs10509477	Imputed	T	DOMINANT	8.97E−05	8.97E−05	1.5819	1.5819	0.6066	0
  rs10517918	Imputed	G	RECESSIVE	6.05E−05	6.05E−05	1.8264	1.8264	0.4972	0
  rs10517924	Imputed	A	RECESSIVE	7.80E−05	7.80E−05	1.7459	1.7459	0.7576	0
  rs10519362	Imputed	G	DOMINANT	0.001678	0.001678	1.4934	1.4934	0.9592	0
  rs10520072	Imputed	T	DOMINANT	0.0005579	0.0005579	0.6664	0.6664	0.9359	0
  rs10737390	Imputed	T	DOMINANT	5.50E−05	5.50E−05	0.6131	0.6131	0.5051	0
  rs10742851	Imputed	T	RECESSIVE	9.69E−05	9.69E−05	0.3726	0.3726	0.5568	0
  rs10743685	Imputed	G	GENOTYPIC	6.86E−05	6.86E−05	2.0019	2.0019	0.8416	0
  rs10743685	Imputed	G	RECESSIVE	1.49E−04	0.0001485	1.8297	1.8297	0.5748	0
  rs10749293	Imputed	G	DOMINANT	6.75E−05	6.75E−05	1.5947	1.5947	0.7622	0
  rs10749294	Imputed	A	DOMINANT	1.82E−04	1.82E−04	1.55	1.55	0.8529	0
  rs10753760	Imputed	T	ADDITIVE	5.13E−05	5.13E−05	1.4174	1.4174	0.7656	0
  rs10753760	Imputed	T	GENOTYPIC	5.49E−05	5.49E−05	2.0466	2.0466	0.7902	0
  rs10772362	Imputed	T	ADDITIVE	1.62E−05	1.62E−05	0.6474	0.6474	0.7786	0
  rs10784891	Imputed	C	ADDITIVE	3.04E−04	0.0003039	0.7309	0.7309	0.7572	0
  rs10784891	Imputed	C	DOMINANT	1.43E−04	1.43E−04	0.6151	0.6151	0.793	0
  rs10784891	Imputed	C	GENOTYPIC	1.13E−03	1.13E−03	0.564	0.564	0.5692	0
  rs10787923	Imputed	G	DOMINANT	6.49E−05	6.49E−05	1.5969	1.5969	0.7212	0
  rs10787924	Imputed	T	DOMINANT	1.60E−04	0.0001596	1.5563	1.5563	0.8327	0
  rs10787949	Imputed	A	DOMINANT	0.0001459	0.0001459	1.5599	1.5599	0.592	0
  rs10787951	Imputed	G	DOMINANT	0.0001459	0.0001459	1.5599	1.5599	0.592	0
  rs10787983	Imputed	C	DOMINANT	0.0001474	0.0001474	1.5574	1.5574	0.6777	0
  rs10794733	Imputed	C	ADDITIVE	0.00276	0.00276	0.7628	0.7628	0.9657	0
  rs10818280	Imputed	C	DOMINANT	1.66E−03	0.00166	0.6922	0.6922	0.8399	0
  rs10860586	Imputed	A	ADDITIVE	9.56E−05	9.56E−05	1.3855	1.3855	0.4436	0
  rs10860586	Imputed	A	GENOTYPIC	9.35E−05	9.35E−05	1.9196	1.9196	0.4483	0
  rs10870473	Imputed	A	ADDITIVE	9.61E−05	9.61E−05	0.569	0.569	0.6419	0
  rs10870473	Imputed	A	DOMINANT	3.52E−05	3.52E−05	0.4776	0.4776	0.9449	0
  rs10879240	Imputed	C	ADDITIVE	5.56E−04	0.0005557	0.7439	0.7439	0.8062	0
  rs10879240	Imputed	C	GENOTYPIC	0.001627	0.001627	0.5771	0.5771	0.5726	0
  rs10879242	Imputed	A	ADDITIVE	2.20E−04	0.0002198	0.7269	0.7269	0.7534	0
  rs10879242	Imputed	A	DOMINANT	7.97E−05	7.97E−05	0.6177	0.6177	0.8661	0
  rs10879245	Imputed	G	ADDITIVE	2.20E−04	0.0002198	0.7269	0.7269	0.7534	0
  rs10879245	Imputed	G	DOMINANT	7.97E−05	7.97E−05	0.6177	0.6177	0.8661	0
  rs10879249	Imputed	T	ADDITIVE	7.98E−05	7.98E−05	0.7098	0.7098	0.7061	0
  rs10879249	Imputed	T	DOMINANT	3.54E−05	3.54E−05	0.6036	0.6036	0.9476	0
  rs10886429	Imputed	A	DOMINANT	1.10E−04	1.10E−04	1.5741	1.5741	0.6665	0
  rs10886449	Imputed	G	DOMINANT	0.0002256	0.0002256	1.5385	1.5385	0.68	0
  rs10886451	Imputed	G	DOMINANT	2.26E−04	0.0002256	1.5385	1.5385	0.68	0
  rs10886452	Imputed	A	DOMINANT	0.0001459	0.0001459	1.5599	1.5599	0.592	0
  rs10886456	Imputed	G	DOMINANT	0.0002256	0.0002256	1.5385	1.5385	0.68	0
  rs10886463	Imputed	C	DOMINANT	0.0001545	0.0001545	1.5578	1.5578	0.6315	0
  rs10886465	Imputed	A	DOMINANT	8.63E−05	8.63E−05	1.5827	1.5827	0.5622	0
  rs10886526	Imputed	C	DOMINANT	1.47E−04	0.0001474	1.5574	1.5574	0.6777	0
  rs10922903	Imputed	C	RECESSIVE	9.19E−05	9.19E−05	0.5329	0.5329	0.4609	0
  rs10941126	Imputed	G	ADDITIVE	1.27E−05	1.27E−05	0.2451	0.2451	0.6218	0
  rs10941126	Imputed	G	DOMINANT	2.81E−05	2.81E−05	0.2509	0.2509	0.6535	0
  rs10947980	Imputed	G	ADDITIVE	7.93E−05	7.93E−05	0.6897	0.6897	0.3212	0
  rs11059376	Imputed	T	ADDITIVE	5.53E−05	5.53E−05	1.5704	1.5704	0.929	0
  rs11072995	Imputed	T	GENOTYPIC	0.0002433	0.0002433	3.2596	3.2596	0.6428	0
  rs11072995	Imputed	T	RECESSIVE	0.0003025	0.0003025	3.164	3.164	0.6989	0
  rs11081202	Genotyped	G	GENOTYPIC	2.03E−03	0.002028	1.979	1.979	0.4228	0
  rs11081202	Genotyped	G	RECESSIVE	5.63E−04	0.0005629	2.0891	2.0891	0.5637	0
  rs110965	Imputed	C	GENOTYPIC	6.88E−03	6.88E−03	1.7493	1.7493	0.9979	0
  rs11124962	Imputed	A	DOMINANT	0.000116	0.000116	1.5786	1.5786	0.4004	0
  rs1116596	Imputed	T	DOMINANT	6.74E−04	0.000674	0.6707	0.6707	0.7616	0
  rs11178531	Imputed	A	ADDITIVE	1.67E−03	1.67E−03	0.7662	0.7662	0.8942	0
  rs11178531	Imputed	A	DOMINANT	2.00E−04	0.0001996	0.6214	0.6214	0.9419	0
  rs11178583	Imputed	A	ADDITIVE	8.27E−05	8.27E−05	0.7104	0.7104	0.7004	0
  rs11178583	Imputed	A	DOMINANT	3.96E−05	3.96E−05	0.6056	0.6056	0.9636	0
  rs11178589	Imputed	T	ADDITIVE	6.68E−05	6.68E−05	0.7079	0.7079	0.7072	0
  rs11178589	Imputed	T	DOMINANT	3.53E−05	3.53E−05	0.6015	0.6015	0.9599	0
  rs11178594	Imputed	C	ADDITIVE	0.0001049	0.0001049	0.7148	0.7148	0.7211	0
  rs11178594	Imputed	C	DOMINANT	4.13E−05	4.13E−05	0.6065	0.6065	0.8956	0
  rs11178602	Imputed	T	ADDITIVE	8.81E−05	8.81E−05	0.7122	0.7122	0.7436	0
  rs11178602	Imputed	T	DOMINANT	3.05E−05	3.05E−05	0.6016	0.6016	0.8568	0
  rs11178648	Imputed	T	ADDITIVE	0.0002031	0.0002031	0.7267	0.7267	0.6332	0
  rs11178648	Imputed	T	DOMINANT	1.72E−05	1.72E−05	0.5945	0.5945	0.939	0
  rs11198877	Imputed	T	DOMINANT	1.33E−04	0.0001326	1.5641	1.5641	0.6136	0
  rs11198942	Imputed	T	DOMINANT	8.97E−05	8.97E−05	1.5819	1.5819	0.6066	0
  rs11221075	Imputed	A	ADDITIVE	0.002129	0.002129	0.6684	0.6684	0.6989	0
  rs11242020	Imputed	T	DOMINANT	0.0005976	0.0005976	0.6685	0.6685	0.6979	0
  rs11242021	Imputed	T	DOMINANT	0.000699	0.000699	0.6712	0.6712	0.8706	0
  rs11242022	Imputed	T	DOMINANT	0.0007669	0.0007669	0.6732	0.6732	0.8443	0
  rs11242023	Imputed	T	DOMINANT	0.0009289	0.0009289	0.677	0.677	0.8728	0
  rs1149349	Imputed	T	DOMINANT	7.39E−05	7.39E−05	1.6656	1.6656	0.8419	0
  rs1149350	Imputed	A	ADDITIVE	1.42E−05	1.42E−05	1.5752	1.5752	0.893	0
  rs1149350	Imputed	A	DOMINANT	5.15E−06	5.15E−06	1.7451	1.7451	0.7691	0
  rs11576627	Imputed	T	ADDITIVE	0.0002162	0.0002162	1.5806	1.5806	0.4132	0
  rs11576627	Imputed	T	DOMINANT	1.75E−04	0.0001751	1.6594	1.6594	0.4028	0
  rs11630050	Imputed	G	GENOTYPIC	0.0001769	0.0001769	3.0849	3.0849	0.8542	0
  rs11630050	Imputed	G	RECESSIVE	0.0001739	0.0001739	3.0436	3.0436	0.9473	0
  rs11633024	Imputed	C	GENOTYPIC	0.0001769	0.0001769	3.0849	3.0849	0.8542	0
  rs11633024	Imputed	C	RECESSIVE	0.0001739	0.0001739	3.0436	3.0436	0.9473	0
  rs11636298	Imputed	G	GENOTYPIC	0.0001106	0.0001106	3.4591	3.4591	0.8474	0
  rs11636298	Imputed	G	RECESSIVE	0.0001586	0.0001586	3.317	3.317	0.9056	0
  rs11637363	Imputed	C	GENOTYPIC	0.0001099	0.0001099	3.1869	3.1869	0.7516	0
  rs11637363	Imputed	C	RECESSIVE	0.0001027	0.0001027	3.1534	3.1534	0.8534	0
  rs11637813	Imputed	A	GENOTYPIC	0.0001769	0.0001769	3.0849	3.0849	0.8542	0
  rs11637813	Imputed	A	RECESSIVE	0.0001739	0.0001739	3.0436	3.0436	0.9473	0
  rs11638043	Imputed	C	GENOTYPIC	1.79E−04	0.0001788	3.0118	3.0118	0.8819	0
  rs11638043	Imputed	C	RECESSIVE	0.0001717	0.0001717	2.9756	2.9756	0.9909	0
  rs11638115	Imputed	A	GENOTYPIC	0.0002433	0.0002433	3.2596	3.2596	0.6428	0
  rs11638115	Imputed	A	RECESSIVE	0.0003025	0.0003025	3.164	3.164	0.6989	0
  rs11638444	Imputed	C	GENOTYPIC	0.0001194	0.0001194	3.4378	3.4378	0.8647	0
  rs11717157	Imputed	T	ADDITIVE	8.91E−05	8.91E−05	1.3969	1.3969	0.7348	0
  rs11717157	Imputed	T	GENOTYPIC	5.30E−05	5.30E−05	2.0995	2.0995	0.9749	0
  rs11724055	Imputed	A	DOMINANT	0.00239	0.00239	0.6839	0.6839	0.4246	0
  rs11743355	Imputed	C	ADDITIVE	1.64E−05	1.64E−05	0.2366	0.2366	0.5626	0
  rs11743355	Imputed	C	DOMINANT	3.44E−05	3.44E−05	0.2417	0.2417	0.589	0
  rs11746806	Imputed	T	ADDITIVE	1.27E−05	1.27E−05	0.2451	0.2451	0.6218	0
  rs11746806	Imputed	T	DOMINANT	2.81E−05	2.81E−05	0.2509	0.2509	0.6535	0
  rs11746959	Imputed	T	ADDITIVE	1.27E−05	1.27E−05	0.2451	0.2451	0.6218	0
  rs11746959	Imputed	T	DOMINANT	2.81E−05	2.81E−05	0.2509	0.2509	0.6535	0
  rs11749272	Imputed	T	DOMINANT	0.0005772	0.0005772	0.6679	0.6679	0.7414	0
  rs11839636	Imputed	C	GENOTYPIC	7.59E−05	7.59E−05	2.2506	2.2506	0.9705	0
  rs11839785	Imputed	C	GENOTYPIC	7.97E−05	7.97E−05	2.2456	2.2456	0.9638	0
  rs11853619	Imputed	C	GENOTYPIC	0.0001175	0.0001175	3.4406	3.4406	0.8594	0
  rs11853619	Imputed	C	RECESSIVE	0.0001702	0.0001702	3.2975	3.2975	0.9191	0
  rs11856780	Imputed	A	GENOTYPIC	0.0001175	0.0001175	3.4406	3.4406	0.8594	0
  rs11856780	Imputed	A	RECESSIVE	0.0001702	0.0001702	3.2975	3.2975	0.9191	0
  rs11901899	Imputed	A	DOMINANT	3.44E−04	0.001093	1.5287	1.539	0.2722	17.07
  rs11903290	Imputed	C	RECESSIVE	0.006295	0.006295	1.7598	1.7598	0.7724	0
  rs11909480	Imputed	G	ADDITIVE	0.001521	0.001521	0.4399	0.4399	0.3262	0
  rs11909480	Imputed	G	DOMINANT	0.001914	0.001964	0.4405	0.4406	0.3163	0.41
  rs11910289	Imputed	T	ADDITIVE	0.001496	0.001496	1.8584	1.8584	0.5088	0
  rs11910289	Imputed	T	DOMINANT	0.001453	0.001453	1.9004	1.9004	0.599	0
  rs11920375	Genotyped	C	GENOTYPIC	7.94E−05	7.94E−05	2.0435	2.0435	0.8995	0
  rs11926319	Imputed	G	DOMINANT	9.79E−05	9.79E−05	0.5435	0.5435	0.854	0
  rs11933744	Imputed	T	RECESSIVE	9.01E−05	9.01E−05	2.5682	2.5682	0.6941	0
  rs11934919	Imputed	C	RECESSIVE	9.01E−05	9.01E−05	2.5682	2.5682	0.6941	0
  rs11934957	Imputed	C	RECESSIVE	9.01E−05	9.01E−05	2.5682	2.5682	0.6941	0
  rs11959206	Imputed	A	RECESSIVE	3.66E−05	3.66E−05	0.5455	0.5455	0.7414	0
  rs12038613	Imputed	C	RECESSIVE	7.06E−05	7.06E−05	0.5252	0.5252	0.5509	0
  rs12151417	Imputed	T	DOMINANT	6.45E−04	0.0006449	1.5021	1.5021	0.7699	0
  rs12153185	Imputed	T	DOMINANT	0.001052	0.001052	0.6792	0.6792	0.8684	0
  rs12182651	Imputed	T	DOMINANT	5.94E−05	5.94E−05	1.9576	1.9576	0.6125	0
  rs12235345	Imputed	C	DOMINANT	3.59E−04	0.005622	1.8464	1.8177	0.2149	34.98
  rs12324786	Imputed	T	GENOTYPIC	0.0002433	0.0002433	3.2596	3.2596	0.6428	0
  rs12324786	Imputed	T	RECESSIVE	0.0003025	0.0003025	3.164	3.164	0.6989	0
  rs12336958	Imputed	G	DOMINANT	7.27E−05	7.27E−05	1.6549	1.6549	0.457	0
  rs12407412	Imputed	C	ADDITIVE	0.0002548	0.0002548	1.5719	1.5719	0.384	0
  rs12407412	Imputed	C	DOMINANT	2.10E−04	2.10E−04	1.6487	1.6487	0.368	0
  rs12418971	Imputed	C	GENOTYPIC	0.001802	0.001802	2.2011	2.2011	0.4612	0
  rs12418971	Imputed	C	RECESSIVE	0.002813	0.002813	2.095	2.095	0.5916	0
  rs1241967	Imputed	T	RECESSIVE	0.000111	0.000111	0.4573	0.4573	0.3307	0
  rs12420184	Imputed	G	DOMINANT	4.91E−05	4.91E−05	0.5847	0.5847	0.5393	0
  rs12433968	Imputed	T	DOMINANT	4.10E−05	4.10E−05	0.6109	0.6109	0.318	0
  rs12445477	Imputed	A	DOMINANT	6.95E−05	6.95E−05	0.5027	0.5027	0.3771	0
  rs12447191	Genotyped	T	ADDITIVE	0.0002095	0.0002095	0.6717	0.6717	0.8037	0
  rs12447191	Genotyped	T	DOMINANT	2.32E−04	0.004396	0.6338	0.6204	0.1898	41.82
  rs12465349	Imputed	A	RECESSIVE	0.00192	0.00192	1.513	1.513	0.7914	0
  rs1247340	Imputed	C	ADDITIVE	5.07E−05	5.07E−05	1.5296	1.5296	0.9256	0
  rs1247340	Imputed	C	DOMINANT	1.08E−05	1.08E−05	1.7083	1.7083	0.8426	0
  rs1247341	Imputed	C	ADDITIVE	5.04E−05	5.04E−05	1.5303	1.5303	0.9761	0
  rs1247341	Imputed	C	DOMINANT	1.08E−05	1.08E−05	1.7098	1.7098	0.7759	0
  rs1247343	Imputed	C	DOMINANT	6.53E−05	6.53E−05	1.6756	1.6756	0.9862	0
  rs12509758	Imputed	C	DOMINANT	0.0001489	0.0001489	1.5799	1.5799	0.3277	0
  rs12515472	Imputed	A	DOMINANT	0.005408	0.005408	1.4022	1.4022	0.5945	0
  rs12548906	Imputed	G	ADDITIVE	3.90E−03	3.90E−03	1.3761	1.3761	0.5561	0
  rs12596240	Imputed	G	DOMINANT	4.46E−05	4.46E−05	0.6107	0.6107	0.5739	0
  rs12618781	Imputed	A	DOMINANT	5.33E−05	5.33E−05	0.5924	0.5924	0.6396	0
  rs12678600	Imputed	A	DOMINANT	5.58E−05	5.58E−05	0.6235	0.6235	0.8084	0
  rs12692229	Imputed	T	ADDITIVE	5.68E−03	0.005681	1.271	1.271	0.7737	0
  rs12713324	Imputed	T	DOMINANT	0.0005653	0.0005653	1.5061	1.5061	0.7503	0
  rs12719415	Imputed	T	DOMINANT	6.99E−04	6.99E−04	0.6712	0.6712	0.8706	0
  rs12820589	Imputed	G	ADDITIVE	3.73E−05	3.73E−05	1.5773	1.5773	0.4594	0
  rs12820589	Imputed	G	DOMINANT	8.50E−05	8.50E−05	1.6354	1.6354	0.3309	0
  rs12831292	Imputed	G	ADDITIVE	1.08E−04	0.0001082	0.7143	0.7143	0.7244	0
  rs12831292	Imputed	G	DOMINANT	3.86E−05	3.86E−05	0.6038	0.6038	0.8742	0
  rs13012636	Imputed	G	RECESSIVE	0.005887	0.005887	1.7676	1.7676	0.7851	0
  rs13038146	Imputed	C	ADDITIVE	0.0001909	0.0001909	1.3722	1.3722	0.8246	0
  rs13038146	Imputed	C	GENOTYPIC	0.0002206	0.0002206	1.9531	1.9531	0.7476	0
  rs13038146	Imputed	C	RECESSIVE	0.00156	0.00156	1.7021	1.7021	0.4049	0
  rs13089860	Imputed	A	DOMINANT	0.001151	0.001151	0.6379	0.6379	0.8916	0
  rs13102419	Imputed	T	RECESSIVE	7.45E−05	7.45E−05	1.7512	1.7512	0.8001	0
  rs13194907	Imputed	A	ADDITIVE	7.20E−05	7.20E−05	1.9871	1.9871	0.9631	0
  rs13194907	Imputed	A	DOMINANT	4.88E−05	4.88E−05	2.0957	2.0957	0.9413	0
  rs13195745	Imputed	A	ADDITIVE	7.54E−05	7.54E−05	1.9837	1.9837	0.9685	0
  rs13195745	Imputed	A	DOMINANT	5.13E−05	5.13E−05	2.0917	2.0917	0.9353	0
  rs13265054	Imputed	T	DOMINANT	0.0001224	0.0001224	0.6362	0.6362	0.7096	0
  rs13273002	Imputed	A	GENOTYPIC	8.64E−05	8.64E−05	0.2714	0.2714	0.8433	0
  rs13282131	Imputed	C	ADDITIVE	0.000217	0.000217	1.3612	1.3612	0.7192	0
  rs13282131	Imputed	C	GENOTYPIC	0.00017	0.00017	1.8797	1.8797	0.7696	0
  rs13282131	Imputed	C	RECESSIVE	0.0009795	0.0009795	1.6011	1.6011	0.9829	0
  rs1330052	Imputed	G	GENOTYPIC	8.27E−05	8.27E−05	2.0747	2.0747	0.9516	0
  rs1335721	Imputed	A	RECESSIVE	7.06E−05	7.06E−05	0.5252	0.5252	0.5509	0
  rs1336382	Imputed	T	DOMINANT	9.54E−05	9.54E−05	1.5804	1.5804	0.6104	0
  rs1336383	Imputed	T	DOMINANT	8.97E−05	8.97E−05	1.5819	1.5819	0.6066	0
  rs1336407	Imputed	T	DOMINANT	1.35E−04	0.0001345	1.5612	1.5612	0.6665	0
  rs1336409	Imputed	T	DOMINANT	0.0001345	0.0001345	1.5612	1.5612	0.6665	0
  rs1336596	Imputed	A	DOMINANT	8.41E−06	8.41E−06	0.5875	0.5875	0.3994	0
  rs13387284	Imputed	A	DOMINANT	4.10E−05	4.10E−05	0.5856	0.5856	0.5635	0
  rs13401462	Imputed	C	DOMINANT	4.87E−06	4.87E−06	1.8734	1.8734	0.4869	0
  rs13409045	Imputed	T	ADDITIVE	8.99E−05	8.99E−05	0.7108	0.7108	0.8294	0
  rs1349284	Imputed	C	GENOTYPIC	7.91E−05	7.91E−05	2.0683	2.0683	0.8608	0
  rs1355715	Imputed	T	ADDITIVE	0.0001691	0.0001691	0.5021	0.5021	0.6625	0
  rs1357696	Imputed	A	GENOTYPIC	8.12E−05	8.12E−05	2.0503	2.0503	0.8139	0
  rs1357698	Imputed	A	GENOTYPIC	7.29E−05	7.29E−05	2.0604	2.0604	0.7974	0
  rs1357699	Imputed	T	GENOTYPIC	7.29E−05	7.29E−05	2.0604	2.0604	0.7974	0
  rs1363273	Imputed	C	RECESSIVE	7.91E−05	7.91E−05	0.5543	0.5543	0.8284	0
  rs1373601	Imputed	A	DOMINANT	6.34E−05	6.34E−05	0.6152	0.6152	0.3644	0
  rs1375829	Imputed	C	GENOTYPIC	7.91E−05	7.91E−05	2.0683	2.0683	0.8608	0
  rs1395748	Imputed	G	DOMINANT	7.51E−05	7.51E−05	0.6306	0.6306	0.7714	0
  rs1414865	Imputed	T	DOMINANT	1.46E−04	0.0001459	1.5599	1.5599	0.592	0
  rs1414873	Imputed	A	DOMINANT	0.0001345	0.0001345	1.5612	1.5612	0.6665	0
  rs1414876	Imputed	C	DOMINANT	1.35E−04	1.35E−04	1.5612	1.5612	0.6665	0
  rs1424643	Imputed	G	ADDITIVE	4.44E−04	0.0004437	1.4199	1.4199	0.4926	0
  rs1424643	Imputed	G	DOMINANT	4.24E−04	0.0004238	1.5226	1.5226	0.7796	0
  rs1424648	Imputed	T	DOMINANT	1.80E−03	1.80E−03	1.4456	1.4456	0.4734	0
  rs1429321	Imputed	A	DOMINANT	7.84E−04	7.84E−04	1.4871	1.4871	0.8099	0
  rs1429326	Imputed	T	ADDITIVE	0.0007358	0.0007358	1.3974	1.3974	0.5449	0
  rs1429326	Imputed	T	DOMINANT	0.0004785	0.0004785	1.5125	1.5125	0.8054	0
  rs1444741	Imputed	A	DOMINANT	3.42E−05	3.42E−05	0.605	0.605	0.3326	0
  rs1449916	Imputed	C	DOMINANT	2.24E−05	2.52E−05	0.5247	0.5244	0.3143	1.22
  rs1459523	Imputed	A	ADDITIVE	8.91E−05	8.91E−05	1.3969	1.3969	0.7348	0
  rs1459523	Imputed	A	GENOTYPIC	5.30E−05	5.30E−05	2.0995	2.0995	0.9749	0
  rs1466352	Imputed	T	GENOTYPIC	7.67E−05	7.67E−05	2.0358	2.0358	0.8969	0
  rs1466353	Imputed	G	GENOTYPIC	7.61E−05	7.61E−05	2.0365	2.0365	0.898	0
  rs1476714	Imputed	A	DOMINANT	0.0007134	0.0007134	0.6713	0.6713	0.8712	0
  rs1486723	Imputed	C	RECESSIVE	0.0003279	0.0003279	0.4982	0.4982	0.4282	0
  rs1495375	Imputed	A	ADDITIVE	0.0002198	0.0002198	0.7269	0.7269	0.7534	0
  rs1495375	Imputed	A	DOMINANT	7.97E−05	7.97E−05	0.6177	0.6177	0.8661	0
  rs1495381	Imputed	T	GENOTYPIC	0.00257	0.00257	1.6918	1.6918	0.6996	0
  rs1495381	Imputed	T	RECESSIVE	0.0004641	0.0004641	1.7303	1.7303	0.8349	0
  rs1498061	Imputed	C	ADDITIVE	1.30E−04	0.0001304	0.5363	0.5363	0.5167	0
  rs1498992	Imputed	G	DOMINANT	1.21E−04	0.0001213	0.6388	0.6388	0.4443	0
  rs1499001	Imputed	T	DOMINANT	4.88E−05	4.88E−05	0.6155	0.6155	0.3606	0
  rs1512988	Imputed	A	ADDITIVE	8.41E−05	8.41E−05	0.7101	0.7101	0.6962	0
  rs1512988	Imputed	A	DOMINANT	4.47E−05	4.47E−05	0.6074	0.6074	0.9954	0
  rs1512989	Imputed	T	ADDITIVE	8.41E−05	8.41E−05	0.7101	0.7101	0.6962	0
  rs1512989	Imputed	T	DOMINANT	4.47E−05	4.47E−05	0.6074	0.6074	0.9954	0
  rs1512991	Imputed	T	ADDITIVE	0.000399	0.000399	0.7396	0.7396	0.8085	0
  rs1512991	Imputed	T	DOMINANT	0.0001092	0.0001092	0.6115	0.6115	0.9069	0
  rs1512991	Imputed	T	GENOTYPIC	0.001397	0.001397	0.5777	0.5777	0.6436	0
  rs1524303	Imputed	T	GENOTYPIC	8.11E−05	8.11E−05	2.0455	2.0455	0.9122	0
  rs1524306	Imputed	C	ADDITIVE	8.11E−05	8.11E−05	1.3995	1.3995	0.7142	0
  rs1524306	Imputed	C	GENOTYPIC	4.94E−05	4.94E−05	2.1056	2.1056	0.9589	0
  rs1524310	Imputed	G	ADDITIVE	7.36E−05	7.36E−05	1.404	1.404	0.6761	0
  rs1524310	Imputed	G	GENOTYPIC	4.72E−05	4.72E−05	2.1176	2.1176	0.9271	0
  rs1524321	Imputed	C	GENOTYPIC	6.09E−05	6.09E−05	2.0756	2.0756	0.7818	0
  rs1527059	Imputed	A	DOMINANT	0.004607	0.004607	0.6321	0.6321	0.3968	0
  rs152707	Imputed	A	ADDITIVE	6.74E−05	6.74E−05	0.7127	0.7127	0.5137	0
  rs152707	Imputed	A	GENOTYPIC	9.17E−05	9.17E−05	0.4993	0.4993	0.3954	0
  rs152712	Genotyped	C	ADDITIVE	4.47E−05	4.47E−05	0.7064	0.7064	0.5198	0
  rs152712	Genotyped	C	GENOTYPIC	5.75E−05	5.75E−05	0.4894	0.4894	0.3791	0
  rs1533994	Imputed	T	GENOTYPIC	6.29E−05	6.29E−05	2.0565	2.0565	0.9308	0
  rs1535866	Imputed	G	DOMINANT	0.0004273	0.001126	1.5272	1.5369	0.2795	14.48
  rs1563773	Imputed	T	GENOTYPIC	8.07E−05	8.07E−05	2.0358	2.0358	0.9519	0
  rs1563774	Imputed	T	GENOTYPIC	8.07E−05	8.07E−05	2.0374	2.0374	0.8993	0
  rs1567740	Imputed	T	ADDITIVE	8.27E−05	8.27E−05	0.7104	0.7104	0.7004	0
  rs1567740	Imputed	T	DOMINANT	3.96E−05	3.96E−05	0.6056	0.6056	0.9636	0
  rs1572573	Imputed	A	DOMINANT	6.70E−05	6.70E−05	1.64	1.64	0.4852	0
  rs1577497	Imputed	C	RECESSIVE	7.41E−05	7.41E−05	0.5263	0.5263	0.5573	0
  rs1581514	Imputed	T	ADDITIVE	8.95E−05	8.95E−05	1.3993	1.3993	0.6083	0
  rs1581514	Imputed	T	GENOTYPIC	5.07E−05	5.07E−05	2.1081	2.1081	0.8699	0
  rs1582321	Imputed	T	DOMINANT	4.17E−05	4.17E−05	0.6096	0.6096	0.5879	0
  rs1582322	Imputed	A	DOMINANT	6.86E−05	6.86E−05	0.6175	0.6175	0.5471	0
  rs1582323	Imputed	A	DOMINANT	6.70E−05	6.70E−05	0.6171	0.6171	0.5101	0
  rs1592485	Imputed	C	DOMINANT	6.80E−05	6.80E−05	0.6167	0.6167	0.53	0
  rs1600954	Imputed	T	ADDITIVE	6.34E−05	6.34E−05	1.4064	1.4064	0.7548	0
  rs1600954	Imputed	T	GENOTYPIC	5.95E−05	5.95E−05	1.9926	1.9926	0.7001	0
  rs16938626	Imputed	G	DOMINANT	6.17E−05	6.17E−05	0.6242	0.6242	0.8167	0
  rs16964300	Imputed	G	ADDITIVE	0.0001511	0.0001511	0.6665	0.6665	0.8478	0
  rs16964300	Imputed	G	DOMINANT	0.0001894	0.003074	0.6299	0.618	0.2025	38.44
  rs16986282	Imputed	G	DOMINANT	0.001578	0.02315	0.4237	0.4355	0.1825	43.73
  rs17007620	Imputed	G	ADDITIVE	6.23E−05	6.23E−05	1.5131	1.5131	0.4281	0
  rs17007620	Imputed	G	DOMINANT	3.79E−05	3.79E−05	1.684	1.684	0.4732	0
  rs17014326	Imputed	G	DOMINANT	3.13E−05	3.13E−05	0.6151	0.6151	0.5429	0
  rs17047957	Imputed	C	DOMINANT	0.001421	0.001421	1.5018	1.5018	0.8023	0
  rs1705261	Imputed	A	RECESSIVE	0.0006289	0.0006289	1.7058	1.7058	0.7466	0
  rs17073341	Imputed	A	ADDITIVE	0.000719	0.03367	2.0963	1.9757	0.1667	47.71
  rs17073341	Imputed	A	DOMINANT	0.0008057	0.0341	2.0915	1.9741	0.1677	47.47
  rs17138702	Imputed	G	ADDITIVE	6.91E−05	6.91E−05	0.6037	0.6037	0.343	0
  rs17189710	Imputed	T	ADDITIVE	0.00017	0.00017	1.3762	1.3762	0.8443	0
  rs17189710	Imputed	T	GENOTYPIC	0.000209	0.000209	1.959	1.959	0.738	0
  rs17189710	Imputed	T	RECESSIVE	0.001525	0.001525	1.7043	1.7043	0.4016	0
  rs17310176	Imputed	T	ADDITIVE	0.0009735	0.001436	0.6909	0.6922	0.3063	4.46
  rs17310176	Imputed	T	DOMINANT	0.0008163	0.01496	0.6548	0.6669	0.1994	39.27
  rs17358860	Imputed	A	DOMINANT	0.002078	0.002078	0.6804	0.6804	0.407	0
  rs17370541	Imputed	T	GENOTYPIC	9.33E−05	9.33E−05	2.055	2.055	0.3333	0
  rs17370541	Imputed	T	RECESSIVE	6.92E−05	6.92E−05	1.969	1.969	0.671	0
  rs17526574	Imputed	G	GENOTYPIC	7.89E−05	7.89E−05	2.2297	2.2297	0.9421	0
  rs17530747	Imputed	T	DOMINANT	8.45E−05	8.45E−05	0.6272	0.6272	0.3668	0
  rs17649114	Imputed	C	DOMINANT	0.002429	0.002429	1.4394	1.4394	0.4375	0
  rs17766172	Imputed	A	RECESSIVE	0.0002007	0.0005167	0.4665	0.4683	0.2878	11.48
  rs1818885	Imputed	G	GENOTYPIC	5.46E−05	5.46E−05	2.1046	2.1046	0.983	0
  rs1832222	Imputed	G	DOMINANT	0.0001515	0.0001515	1.5562	1.5562	0.6814	0
  rs1861327	Imputed	G	DOMINANT	4.17E−05	4.17E−05	0.6096	0.6096	0.5879	0
  rs1868581	Imputed	G	ADDITIVE	7.20E−05	7.20E−05	1.4042	1.4042	0.6755	0
  rs1868581	Imputed	G	GENOTYPIC	4.84E−05	4.84E−05	2.1147	2.1147	0.9348	0
  rs1874313	Imputed	A	ADDITIVE	0.0001307	0.0001307	0.7177	0.7177	0.586	0
  rs1874313	Imputed	A	DOMINANT	5.03E−05	5.03E−05	0.6096	0.6096	0.9203	0
  rs1876409	Imputed	C	DOMINANT	6.56E−05	6.56E−05	0.6278	0.6278	0.8104	0
  rs1913201	Imputed	G	ADDITIVE	0.0004633	0.0004633	0.7392	0.7392	0.7118	0
  rs1913201	Imputed	G	DOMINANT	0.0002642	0.0002642	0.6285	0.6285	0.7714	0
  rs1913201	Imputed	G	GENOTYPIC	0.001515	0.001515	0.574	0.574	0.5208	0
  rs1916922	Imputed	T	GENOTYPIC	8.22E−05	8.22E−05	2.1096	2.1096	0.9454	0
  rs1936871	Genotyped	G	DOMINANT	9.04E−05	9.04E−05	0.6214	0.6214	0.3679	0
  rs1961157	Imputed	T	RECESSIVE	8.54E−05	8.54E−05	0.5553	0.5553	0.4429	0
  rs1987179	Imputed	T	ADDITIVE	0.001935	0.001935	0.7236	0.7236	0.8673	0
  rs1987179	Imputed	T	DOMINANT	0.000396	0.000396	0.6536	0.6536	0.8664	0
  rs1990023	Imputed	T	DOMINANT	0.0005303	0.0005303	0.6661	0.6661	0.7286	0
  rs1995025	Imputed	C	DOMINANT	0.001961	0.001961	1.5088	1.5088	0.5064	0
  rs2016194	Imputed	G	DOMINANT	0.0007182	0.0007182	0.6718	0.6718	0.875	0
  rs2023651	Imputed	T	ADDITIVE	3.73E−05	3.73E−05	0.6532	0.6532	0.5375	0
  rs2024902	Imputed	A	ADDITIVE	7.20E−05	7.20E−05	1.9871	1.9871	0.9631	0
  rs2024902	Imputed	A	DOMINANT	4.88E−05	4.88E−05	2.0957	2.0957	0.9413	0
  rs2025107	Imputed	A	DOMINANT	5.94E−05	5.94E−05	1.9576	1.9576	0.6125	0
  rs2025108	Imputed	T	DOMINANT	8.65E−05	8.65E−05	1.9168	1.9168	0.7647	0
  rs2031987	Imputed	T	GENOTYPIC	7.93E−05	7.93E−05	2.2431	2.2431	0.9603	0
  rs2052428	Imputed	C	DOMINANT	0.0001903	0.0001903	0.6109	0.6109	0.7253	0
  rs2053230	Imputed	C	ADDITIVE	6.65E−05	6.65E−05	0.5491	0.5491	0.7036	0
  rs2062448	Imputed	T	DOMINANT	9.26E−05	9.26E−05	0.5424	0.5424	0.9524	0
  rs2063420	Imputed	C	RECESSIVE	8.43E−05	8.43E−05	1.8009	1.8009	0.8175	0
  rs2063591	Imputed	C	ADDITIVE	0.001336	0.001336	0.7622	0.7622	0.8243	0
  rs2063591	Imputed	C	DOMINANT	0.0001828	0.0001828	0.619	0.619	0.9374	0
  rs208026	Genotyped	A	DOMINANT	0.0009159	0.0009159	1.4777	1.4777	0.8719	0
  rs208029	Imputed	T	DOMINANT	0.0032	0.0032	1.4242	1.4242	0.911	0
  rs208757	Imputed	G	DOMINANT	0.002063	0.002063	1.4401	1.4401	0.8897	0
  rs2095586	Imputed	A	DOMINANT	9.55E−05	9.55E−05	1.582	1.582	0.6057	0
  rs2095606	Imputed	A	DOMINANT	6.15E−06	6.15E−06	0.5812	0.5812	0.4893	0
  rs2102374	Imputed	A	ADDITIVE	2.38E−05	2.38E−05	0.6664	0.6664	0.4161	0
  rs2102374	Imputed	A	DOMINANT	1.59E−05	1.59E−05	0.6016	0.6016	0.9592	0
  rs2108426	Imputed	C	DOMINANT	0.0007182	0.0007182	0.6718	0.6718	0.875	0
  rs2110664	Imputed	A	DOMINANT	0.0002336	0.0002336	1.5536	1.5536	0.3488	0
  rs2132242	Imputed	A	ADDITIVE	0.0001077	0.0001077	0.7156	0.7156	0.7142	0
  rs2132242	Imputed	A	DOMINANT	5.48E−05	5.48E−05	0.6098	0.6098	0.9205	0
  rs2158958	Imputed	A	DOMINANT	0.000699	0.000699	0.6712	0.6712	0.8706	0
  rs2158961	Imputed	G	DOMINANT	0.000697	0.000697	0.6715	0.6715	0.7678	0
  rs2163046	Imputed	A	DOMINANT	0.0008376	0.0008376	1.4873	1.4873	0.9201	0
  rs2180286	Imputed	G	DOMINANT	0.001385	0.001385	0.6528	0.6528	0.6017	0
  rs2180684	Imputed	A	DOMINANT	0.0009602	0.0009602	1.6598	1.6598	0.8934	0
  rs2188079	Imputed	C	ADDITIVE	7.00E−05	7.00E−05	1.3978	1.3978	0.4286	0
  rs2188079	Imputed	C	GENOTYPIC	4.81E−05	4.81E−05	2.0195	2.0195	0.6225	0
  rs2190598	Imputed	T	DOMINANT	0.000699	0.000699	0.6712	0.6712	0.8706	0
  rs2190600	Imputed	A	DOMINANT	0.0009994	0.0009994	0.6775	0.6775	0.9204	0
  rs2224184	Genotyped	T	DOMINANT	0.001793	0.001793	0.6621	0.6621	0.6649	0
  rs2247066	Imputed	A	DOMINANT	7.51E−05	7.51E−05	0.6306	0.6306	0.7714	0
  rs2248236	Imputed	C	ADDITIVE	0.0005358	0.0005358	0.6815	0.6815	0.4894	0
  rs2248236	Imputed	C	DOMINANT	0.0001555	0.0001555	0.619	0.619	0.8208	0
  rs2265733	Imputed	C	ADDITIVE	2.38E−05	2.38E−05	0.6664	0.6664	0.4161	0
  rs2265733	Imputed	C	DOMINANT	1.59E−05	1.59E−05	0.6016	0.6016	0.9592	0
  rs2270584	Imputed	A	ADDITIVE	0.0001667	0.0001667	0.7239	0.7239	0.6562	0
  rs2270584	Imputed	A	DOMINANT	1.41E−05	1.41E−05	0.5915	0.5915	0.9146	0
  rs2270586	Imputed	A	ADDITIVE	0.0001716	0.0001716	0.7243	0.7243	0.6525	0
  rs2270586	Imputed	A	DOMINANT	1.54E−05	1.54E−05	0.5928	0.5928	0.9252	0
  rs229775	Imputed	A	RECESSIVE	0.000111	0.000111	0.4573	0.4573	0.3307	0
  rs229815	Imputed	T	RECESSIVE	0.0002282	0.0002282	0.4565	0.4565	0.4856	0
  rs229829	Imputed	C	RECESSIVE	0.0005435	0.0005435	0.5446	0.5446	0.5763	0
  rs229831	Imputed	A	RECESSIVE	0.0002275	0.002067	0.469	0.4773	0.2519	23.81
  rs2317057	Imputed	T	ADDITIVE	0.002089	0.002089	0.7151	0.7151	0.9648	0
  rs2322100	Genotyped	T	RECESSIVE	0.000848	0.000848	2.0921	2.0921	0.3268	0
  rs2322101	Imputed	A	RECESSIVE	0.0008488	0.0008488	2.0923	2.0923	0.3199	0
  rs2327929	Imputed	G	RECESSIVE	6.56E−05	6.56E−05	1.7968	1.7968	0.3419	0
  rs2332844	Imputed	A	ADDITIVE	2.83E−05	2.83E−05	1.7997	1.7997	0.9786	0
  rs2332844	Imputed	A	RECESSIVE	0.0001148	0.0001148	1.8396	1.8396	0.9347	0
  rs2349170	Imputed	G	DOMINANT	0.0004675	0.0004675	1.5226	1.5226	0.4042	0
  rs2356722	Imputed	G	DOMINANT	2.78E−05	2.78E−05	0.6136	0.6136	0.5952	0
  rs2364956	Imputed	T	ADDITIVE	7.88E−05	7.88E−05	1.5326	1.5326	0.464	0
  rs2373793	Imputed	G	ADDITIVE	0.0006153	0.0006153	1.4555	1.4555	0.5436	0
  rs2373793	Imputed	G	DOMINANT	0.0002422	0.0002422	1.5984	1.5984	0.3199	0
  rs238252	Imputed	G	ADDITIVE	3.92E−05	3.92E−05	1.6115	1.6115	0.7369	0
  rs238252	Imputed	G	DOMINANT	2.65E−05	2.65E−05	1.7462	1.7462	0.5867	0
  rs2383903	Imputed	G	DOMINANT	9.89E−05	9.89E−05	0.6336	0.6336	0.873	0
  rs2387945	Imputed	G	DOMINANT	0.002288	0.002288	1.4967	1.4967	0.5359	0
  rs2389863	Imputed	A	DOMINANT	0.0005489	0.0005489	0.6585	0.6585	0.8176	0
  rs2389866	Imputed	C	DOMINANT	0.000396	0.000396	0.6536	0.6536	0.8664	0
  rs2389869	Imputed	C	DOMINANT	0.000396	0.000396	0.6536	0.6536	0.8664	0
  rs2389870	Genotyped	C	DOMINANT	0.003433	0.003433	0.6945	0.6945	0.3965	0
  rs2418494	Imputed	G	ADDITIVE	0.002097	0.002097	0.7772	0.7772	0.4019	0
  rs2418494	Imputed	G	GENOTYPIC	0.001772	0.001772	0.5989	0.5989	0.3574	0
  rs2418541	Imputed	A	DOMINANT	0.0005303	0.0005303	0.6661	0.6661	0.7286	0
  rs2418542	Imputed	A	DOMINANT	0.0005772	0.0005772	0.6679	0.6679	0.7414	0
  rs2423556	Imputed	C	DOMINANT	0.001354	0.001354	0.6507	0.6507	0.5885	0
  rs2437688	Imputed	C	ADDITIVE	0.004791	0.004791	1.4661	1.4661	0.9462	0
  rs2456809	Imputed	G	DOMINANT	6.91E−05	6.91E−05	0.6286	0.6286	0.7989	0
  rs2456811	Imputed	T	ADDITIVE	2.64E−05	2.64E−05	0.6679	0.6679	0.4268	0
  rs2456811	Imputed	T	DOMINANT	1.79E−05	1.79E−05	0.6034	0.6034	0.9743	0
  rs2476976	Imputed	C	DOMINANT	0.0002835	0.0002835	1.5277	1.5277	0.6105	0
  rs2484911	Imputed	A	DOMINANT	0.0002659	0.0002659	1.5304	1.5304	0.8231	0
  rs2488557	Imputed	C	DOMINANT	9.46E−05	9.46E−05	0.5776	0.5776	0.6502	0
  rs250162	Imputed	C	ADDITIVE	0.000113	0.0003838	0.6768	0.6731	0.2772	15.32
  rs250162	Imputed	C	DOMINANT	4.84E−05	0.0006095	0.6135	0.6056	0.2344	29.27
  rs2560708	Imputed	T	ADDITIVE	0.0002656	0.0002656	0.6487	0.6487	0.5707	0
  rs2617841	Imputed	G	DOMINANT	0.0002103	0.0002103	0.633	0.633	0.4225	0
  rs2622499	Imputed	G	DOMINANT	0.0004741	0.0004741	0.6573	0.6573	0.8397	0
  rs264129	Imputed	T	DOMINANT	0.0007594	0.0007594	0.6718	0.6718	0.7413	0
  rs2642936	Imputed	T	ADDITIVE	9.35E−05	9.35E−05	1.4936	1.4936	0.3776	0
  rs2660633	Imputed	A	DOMINANT	6.56E−05	6.56E−05	0.6278	0.6278	0.8104	0
  rs2660634	Imputed	C	DOMINANT	6.56E−05	6.56E−05	0.6278	0.6278	0.8104	0
  rs2660648	Imputed	A	ADDITIVE	2.38E−05	2.38E−05	0.6664	0.6664	0.4161	0
  rs2660648	Imputed	A	DOMINANT	1.59E−05	1.59E−05	0.6016	0.6016	0.9592	0
  rs2681505	Imputed	T	ADDITIVE	1.62E−05	1.62E−05	0.6474	0.6474	0.7786	0
  rs277411	Imputed	G	DOMINANT	4.27E−05	4.27E−05	0.3261	0.3261	0.7363	0
  rs2832634	Imputed	G	ADDITIVE	0.001422	0.001422	1.8637	1.8637	0.4977	0
  rs2832637	Imputed	T	ADDITIVE	0.001422	0.001422	1.8637	1.8637	0.4977	0
  rs2843167	Imputed	A	DOMINANT	4.64E−05	4.64E−05	0.6208	0.6208	0.6602	0
  rs2876227	Imputed	C	ADDITIVE	0.0004318	0.0004318	1.3526	1.3526	0.8494	0
  rs2876227	Imputed	C	GENOTYPIC	0.0004406	0.0004406	1.9073	1.9073	0.726	0
  rs2882097	Imputed	A	DOMINANT	8.97E−05	8.97E−05	1.5819	1.5819	0.6066	0
  rs2909862	Imputed	G	DOMINANT	8.19E−05	8.19E−05	1.7275	1.7275	0.4161	0
  rs3001945	Imputed	T	DOMINANT	0.001929	0.001929	1.5254	1.5254	0.656	0
  rs3011020	Imputed	C	DOMINANT	0.002194	0.002194	1.4992	1.4992	0.5299	0
  rs36071725	Genotyped	C	ADDITIVE	4.45E−06	4.45E−06	1.4999	1.4999	0.8099	0
  rs36071725	Genotyped	C	GENOTYPIC	2.95E−06	1.95E−05	2.5235	2.5053	0.2811	13.92
  rs373983	Imputed	G	DOMINANT	0.001847	0.001847	1.4715	1.4715	0.5548	0
  rs3743794	Imputed	G	DOMINANT	9.02E−05	9.02E−05	0.6224	0.6224	0.5016	0
  rs3756154	Imputed	C	ADDITIVE	0.001935	0.001935	0.7236	0.7236	0.8673	0
  rs3756154	Imputed	C	DOMINANT	0.000396	0.000396	0.6536	0.6536	0.8664	0
  rs3775850	Imputed	A	DOMINANT	0.001884	0.001884	0.6779	0.6779	0.3941	0
  rs3775851	Imputed	C	DOMINANT	0.00239	0.00239	0.6839	0.6839	0.4246	0
  rs3793044	Imputed	C	ADDITIVE	9.83E−05	9.83E−05	1.9638	1.9638	0.8837	0
  rs3793044	Imputed	C	DOMINANT	6.76E−05	6.76E−05	2.0697	2.0697	0.9811	0
  rs3793053	Imputed	C	DOMINANT	5.01E−05	5.01E−05	1.9787	1.9787	0.624	0
  rs3796246	Imputed	G	DOMINANT	8.90E−05	8.90E−05	0.5398	0.5398	0.4358	0
  rs3806003	Imputed	A	ADDITIVE	9.83E−05	9.83E−05	1.9638	1.9638	0.8837	0
  rs3806003	Imputed	A	DOMINANT	6.76E−05	6.76E−05	2.0697	2.0697	0.9811	0
  rs3806004	Imputed	T	DOMINANT	5.94E−05	5.94E−05	1.9576	1.9576	0.6125	0
  rs3806010	Imputed	T	DOMINANT	5.94E−05	5.94E−05	1.9576	1.9576	0.6125	0
  rs3806014	Imputed	T	DOMINANT	5.67E−05	5.67E−05	1.9649	1.9649	0.6221	0
  rs3806015	Imputed	A	DOMINANT	5.94E−05	5.94E−05	1.9576	1.9576	0.6125	0
  rs3806018	Imputed	A	DOMINANT	7.82E−05	7.82E−05	1.9419	1.9419	0.5908	0
  rs3806019	Imputed	A	DOMINANT	5.94E−05	5.94E−05	1.9576	1.9576	0.6125	0
  rs3806024	Imputed	T	DOMINANT	5.01E−05	5.01E−05	1.9787	1.9787	0.624	0
  rs3915080	Imputed	A	GENOTYPIC	5.44E−05	5.44E−05	2.0907	2.0907	0.9248	0
  rs3942254	Imputed	T	ADDITIVE	0.0001416	0.0001416	0.7166	0.7166	0.775	0
  rs3942254	Imputed	T	DOMINANT	7.52E−05	7.52E−05	0.6139	0.6139	0.912	0
  rs3945085	Imputed	A	DOMINANT	6.75E−05	6.75E−05	1.5947	1.5947	0.7622	0
  rs3976737	Imputed	G	ADDITIVE	4.73E−05	4.73E−05	0.6147	0.6147	0.6857	0
  rs399485	Imputed	A	DOMINANT	0.001322	0.001322	1.4553	1.4553	0.9598	0
  rs4029119	Imputed	G	ADDITIVE	2.65E−05	2.65E−05	0.2569	0.2569	0.4764	0
  rs4029119	Imputed	G	DOMINANT	5.81E−05	5.81E−05	0.2637	0.2637	0.5057	0
  rs4076201	Imputed	G	GENOTYPIC	0.0001779	0.0001779	3.0129	3.0129	0.881	0
  rs4076201	Imputed	G	RECESSIVE	0.0001745	0.0001745	2.9721	2.9721	0.9936	0
  rs41395945	Imputed	G	ADDITIVE	0.001422	0.001422	1.8637	1.8637	0.4977	0
  rs41395945	Imputed	G	DOMINANT	0.001383	0.001383	1.9054	1.9054	0.5854	0
  rs4146972	Genotyped	T	DOMINANT	0.002023	0.002023	1.4758	1.4758	0.7768	0
  rs4238087	Imputed	G	DOMINANT	0.001528	0.002511	0.6487	0.6459	0.2941	9.14
  rs4251569	Imputed	T	ADDITIVE	0.000865	0.000865	0.6585	0.6585	0.319	0
  rs4251569	Imputed	T	DOMINANT	0.001524	0.002494	0.6487	0.6458	0.2944	9.05
  rs4273613	Imputed	T	ADDITIVE	1.27E−05	1.27E−05	0.2451	0.2451	0.6218	0
  rs4273613	Imputed	T	DOMINANT	2.81E−05	2.81E−05	0.2509	0.2509	0.6535	0
  rs4291049	Imputed	T	RECESSIVE	6.91E−05	6.91E−05	0.5605	0.5605	0.8377	0
  rs4315598	Imputed	T	ADDITIVE	0.0002132	0.0002132	1.369	1.369	0.8084	0
  rs4315598	Imputed	T	GENOTYPIC	0.0002436	0.0002436	1.9445	1.9445	0.7616	0
  rs4315598	Imputed	T	RECESSIVE	0.001637	0.001637	1.6981	1.6981	0.4109	0
  rs4321395	Imputed	A	DOMINANT	4.10E−05	4.10E−05	0.5856	0.5856	0.5635	0
  rs4321596	Genotyped	T	RECESSIVE	0.001013	0.001013	2.3233	2.3233	0.5608	0
  rs4324417	Imputed	T	DOMINANT	9.41E−05	9.41E−05	1.6531	1.6531	0.6731	0
  rs4328619	Genotyped	G	DOMINANT	0.002587	0.002587	0.6704	0.6704	0.826	0
  rs4338909	Imputed	T	ADDITIVE	9.61E−05	9.61E−05	1.3842	1.3842	0.8254	0
  rs4370878	Imputed	G	DOMINANT	9.82E−05	9.82E−05	1.5785	1.5785	0.7378	0
  rs4379434	Genotyped	T	DOMINANT	9.48E−05	9.48E−05	1.6163	1.6163	0.9593	0
  rs4416407	Imputed	T	DOMINANT	0.0001694	0.0001694	1.6929	1.6929	0.489	0
  rs4417899	Imputed	C	RECESSIVE	0.000157	0.000157	0.5892	0.5892	0.4805	0
  rs4442732	Imputed	A	ADDITIVE	8.41E−05	8.41E−05	0.6531	0.6531	0.3436	0
  rs4444612	Imputed	G	ADDITIVE	0.0001677	0.0001677	1.3768	1.3768	0.8476	0
  rs4444612	Imputed	G	GENOTYPIC	0.00021	0.00021	1.9589	1.9589	0.738	0
  rs4444612	Imputed	G	RECESSIVE	0.001571	0.001571	1.7015	1.7015	0.4057	0
  rs4450660	Imputed	C	DOMINANT	8.36E−05	8.36E−05	1.5918	1.5918	0.5023	0
  rs4509702	Imputed	C	DOMINANT	9.82E−05	9.82E−05	1.5785	1.5785	0.7378	0
  rs4526920	Imputed	G	GENOTYPIC	7.93E−05	7.93E−05	2.2431	2.2431	0.9603	0
  rs4533145	Imputed	T	DOMINANT	9.22E−05	9.22E−05	0.5529	0.5529	0.3518	0
  rs4557006	Imputed	A	DOMINANT	8.75E−05	8.75E−05	0.5972	0.5972	0.5878	0
  rs4570530	Imputed	C	DOMINANT	9.82E−05	9.82E−05	1.5785	1.5785	0.7378	0
  rs4615971	Imputed	C	DOMINANT	0.0001298	0.0001298	1.5635	1.5635	0.7109	0
  rs4628119	Imputed	A	DOMINANT	6.11E−05	6.11E−05	0.6205	0.6205	0.3365	0
  rs4664443	Imputed	G	ADDITIVE	7.56E−05	7.56E−05	0.7086	0.7086	0.8496	0
  rs4688259	Imputed	T	DOMINANT	0.0001678	0.0001678	1.6935	1.6935	0.4878	0
  rs4688632	Imputed	G	RECESSIVE	0.0001642	0.0001642	0.5987	0.5987	0.51	0
  rs4695284	Imputed	A	ADDITIVE	8.64E−05	8.64E−05	1.894	1.894	0.3836	0
  rs4700302	Imputed	A	ADDITIVE	9.09E−05	9.09E−05	0.5243	0.5243	0.8943	0
  rs4702720	Imputed	A	ADDITIVE	0.0001094	0.0001094	0.6414	0.6414	0.5372	0
  rs4702720	Imputed	A	DOMINANT	0.0001621	0.0001621	0.5989	0.5989	0.3199	0
  rs4711091	Genotyped	G	GENOTYPIC	9.08E−05	9.08E−05	1.8967	1.8967	0.4866	0
  rs4714484	Imputed	A	ADDITIVE	4.13E−05	4.13E−05	0.6276	0.6276	0.4538	0
  rs4736802	Imputed	G	DOMINANT	7.12E−05	7.12E−05	1.6304	1.6304	0.9501	0
  rs4760785	Imputed	A	ADDITIVE	0.0004633	0.0004633	0.7392	0.7392	0.7118	0
  rs4760785	Imputed	A	DOMINANT	0.0002642	0.0002642	0.6285	0.6285	0.7714	0
  rs4760785	Imputed	A	GENOTYPIC	0.001515	0.001515	0.574	0.574	0.5208	0
  rs4760894	Imputed	T	ADDITIVE	0.0004633	0.0004633	0.7392	0.7392	0.7118	0
  rs4760894	Imputed	T	DOMINANT	0.0002642	0.0002642	0.6285	0.6285	0.7714	0
  rs4760894	Imputed	T	GENOTYPIC	0.001515	0.001515	0.574	0.574	0.5208	0
  rs4760895	Imputed	A	ADDITIVE	0.0004633	0.0004633	0.7392	0.7392	0.7118	0
  rs4760895	Imputed	A	DOMINANT	0.0002642	0.0002642	0.6285	0.6285	0.7714	0
  rs4760895	Imputed	A	GENOTYPIC	0.001515	0.001515	0.574	0.574	0.5208	0
  rs4764738	Imputed	A	ADDITIVE	5.30E−05	5.30E−05	1.4051	1.4051	0.3785	0
  rs4764738	Imputed	A	GENOTYPIC	5.29E−05	5.29E−05	1.9728	1.9728	0.3836	0
  rs4764974	Imputed	T	ADDITIVE	9.56E−05	9.56E−05	1.3855	1.3855	0.4436	0
  rs4764974	Imputed	T	GENOTYPIC	9.35E−05	9.35E−05	1.9196	1.9196	0.4483	0
  rs4798366	Imputed	G	RECESSIVE	0.001711	0.001711	1.8332	1.8332	0.3582	0
  rs483159	Imputed	T	DOMINANT	0.004772	0.004772	1.4202	1.4202	0.9716	0
  rs4836502	Imputed	T	DOMINANT	0.000699	0.000699	0.6712	0.6712	0.8706	0
  rs4836507	Imputed	C	DOMINANT	0.0009994	0.0009994	0.6775	0.6775	0.9204	0
  rs4836744	Imputed	A	ADDITIVE	0.0006425	0.0006425	0.7345	0.7345	0.7018	0
  rs4836744	Imputed	A	DOMINANT	0.001186	0.001186	0.6854	0.6854	0.8412	0
  rs4848944	Genotyped	C	RECESSIVE	0.0002524	0.003005	0.5945	0.5819	0.2143	35.17
  rs4851529	Imputed	A	DOMINANT	0.0003125	0.0003125	0.6476	0.6476	0.4109	0
  rs4851531	Imputed	T	DOMINANT	0.000688	0.0011	0.6621	0.6602	0.2981	7.64
  rs4858046	Genotyped	T	GENOTYPIC	7.90E−05	7.90E−05	2.0533	2.0533	0.925	0
  rs4878214	Imputed	A	ADDITIVE	9.56E−05	9.56E−05	0.6477	0.6477	0.3504	0
  rs4880803	Imputed	A	ADDITIVE	0.003664	0.003664	0.7694	0.7694	0.9093	0
  rs489441	Imputed	G	ADDITIVE	3.10E−05	3.10E−05	1.4992	1.4992	0.6179	0
  rs489441	Imputed	G	DOMINANT	8.27E−05	8.27E−05	1.6072	1.6072	0.8697	0
  rs4896568	Imputed	T	DOMINANT	8.36E−05	8.36E−05	0.6231	0.6231	0.3985	0
  rs4938851	Imputed	T	DOMINANT	0.001901	0.001901	1.4515	1.4515	0.4953	0
  rs4964416	Imputed	C	DOMINANT	0.0004167	0.0004167	0.6251	0.6251	0.6468	0
  rs5756669	Imputed	C	DOMINANT	9.41E−05	9.41E−05	1.6531	1.6531	0.6731	0
  rs6033138	Imputed	C	ADDITIVE	0.000116	0.000116	1.3837	1.3837	0.8829	0
  rs6033138	Imputed	C	GENOTYPIC	0.0001829	0.0001829	1.9484	1.9484	0.7574	0
  rs6033138	Imputed	C	RECESSIVE	0.001659	0.001659	1.6769	1.6769	0.4494	0
  rs6040619	Imputed	C	ADDITIVE	0.0001132	0.0001132	1.3881	1.3881	0.5479	0
  rs6040619	Imputed	C	GENOTYPIC	9.53E−05	9.53E−05	2.0334	2.0334	0.8541	0
  rs6040619	Imputed	C	RECESSIVE	0.0005843	0.0005843	1.7879	1.7879	0.803	0
  rs6040625	Imputed	T	ADDITIVE	0.0001123	0.0001123	1.3888	1.3888	0.589	0
  rs6040625	Imputed	T	GENOTYPIC	0.0001128	0.0001128	2.0214	2.0214	0.9212	0
  rs6040625	Imputed	T	RECESSIVE	0.0007645	0.0007645	1.7684	1.7684	0.7342	0
  rs6040630	Imputed	A	ADDITIVE	0.0001671	0.0001671	1.3767	1.3767	0.7848	0
  rs6040630	Imputed	A	GENOTYPIC	0.0001796	0.0001796	1.9741	1.9741	0.807	0
  rs6040630	Imputed	A	RECESSIVE	0.001227	0.001227	1.7241	1.7241	0.4626	0
  rs6040633	Imputed	A	ADDITIVE	0.000204	0.000204	1.3703	1.3703	0.8149	0
  rs6040633	Imputed	A	GENOTYPIC	0.0002355	0.0002355	1.9475	1.9475	0.7566	0
  rs6040633	Imputed	A	RECESSIVE	0.001596	0.001596	1.6999	1.6999	0.4082	0
  rs6040634	Imputed	T	ADDITIVE	0.0001909	0.0001909	1.3722	1.3722	0.8246	0
  rs6040634	Imputed	T	GENOTYPIC	0.0002206	0.0002206	1.9531	1.9531	0.7476	0
  rs6040634	Imputed	T	RECESSIVE	0.00156	0.00156	1.7021	1.7021	0.4049	0
  rs6040636	Imputed	T	ADDITIVE	0.0001672	0.0001672	1.3761	1.3761	0.8442	0
  rs6040636	Imputed	T	GENOTYPIC	0.0002085	0.0002085	1.9585	1.9585	0.7388	0
  rs6040636	Imputed	T	RECESSIVE	0.00156	0.00156	1.7021	1.7021	0.4049	0
  rs6040638	Imputed	C	ADDITIVE	0.0001909	0.0001909	1.3722	1.3722	0.8246	0
  rs6040638	Imputed	C	GENOTYPIC	0.0002206	0.0002206	1.9531	1.9531	0.7476	0
  rs6040638	Imputed	C	RECESSIVE	0.00156	0.00156	1.7021	1.7021	0.4049	0
  rs6040644	Imputed	A	ADDITIVE	0.0001909	0.0001909	1.3722	1.3722	0.8246	0
  rs6040644	Imputed	A	GENOTYPIC	0.0002206	0.0002206	1.9531	1.9531	0.7476	0
  rs6040644	Imputed	A	RECESSIVE	0.00156	0.00156	1.7021	1.7021	0.4049	0
  rs6040667	Imputed	T	ADDITIVE	0.0002664	0.0002664	1.3662	1.3662	0.8727	0
  rs6040667	Imputed	T	GENOTYPIC	0.0003065	0.0003065	1.9386	1.9386	0.7287	0
  rs6040667	Imputed	T	RECESSIVE	0.002069	0.002069	1.6903	1.6903	0.423	0
  rs6040668	Imputed	C	ADDITIVE	0.0002909	0.0002909	1.3643	1.3643	0.8891	0
  rs6040668	Imputed	C	GENOTYPIC	0.0003326	0.0003326	1.9325	1.9325	0.7115	0
  rs6040668	Imputed	C	RECESSIVE	0.00224	0.00224	1.6839	1.6839	0.406	0
  rs6043066	Genotyped	G	DOMINANT	0.000733	0.01784	1.4888	1.4596	0.1886	42.14
  rs6048146	Imputed	G	DOMINANT	0.0005426	0.0005426	2.6562	2.6562	0.6095	0
  rs6082725	Genotyped	T	DOMINANT	0.0005426	0.0005426	2.6562	2.6562	0.6095	0
  rs6131206	Imputed	C	ADDITIVE	0.002048	0.002048	1.3126	1.3126	0.4818	0
  rs6131208	Imputed	T	ADDITIVE	0.0002137	0.0002137	1.3725	1.3725	0.8701	0
  rs6131208	Imputed	T	GENOTYPIC	0.0002553	0.0002553	1.9551	1.9551	0.7372	0
  rs6131208	Imputed	T	RECESSIVE	0.00182	0.00182	1.7011	1.7011	0.4342	0
  rs6134243	Imputed	C	ADDITIVE	0.0001909	0.0001909	1.3722	1.3722	0.8246	0
  rs6134243	Imputed	C	GENOTYPIC	0.0002206	0.0002206	1.9531	1.9531	0.7476	0
  rs6134243	Imputed	C	RECESSIVE	0.00156	0.00156	1.7021	1.7021	0.4049	0
  rs6136020	Imputed	A	DOMINANT	6.99E−05	7.15E−05	0.5953	0.5953	0.3168	0.19
  rs613799	Imputed	C	DOMINANT	0.0002827	0.0002827	1.5657	1.5657	0.629	0
  rs644041	Imputed	G	ADDITIVE	9.69E−05	9.69E−05	1.4631	1.4631	0.6439	0
  rs644041	Imputed	G	DOMINANT	0.0001835	0.0001835	1.5751	1.5751	0.8914	0
  rs647645	Imputed	C	ADDITIVE	2.08E−05	2.08E−05	0.7025	0.7025	0.8072	0
  rs647645	Imputed	C	GENOTYPIC	1.62E−05	1.62E−05	0.4822	0.4822	0.9069	0
  rs647645	Imputed	C	RECESSIVE	4.05E−05	4.05E−05	0.5474	0.5474	0.5771	0
  rs6495554	Imputed	C	GENOTYPIC	0.0001138	0.0001138	3.4509	3.4509	0.8527	0
  rs6495554	Imputed	C	RECESSIVE	0.0001586	0.0001586	3.317	3.317	0.9056	0
  rs6495555	Imputed	C	GENOTYPIC	0.0001138	0.0001138	3.4509	3.4509	0.8527	0
  rs6495555	Imputed	C	RECESSIVE	0.0001586	0.0001586	3.317	3.317	0.9056	0
  rs6544728	Imputed	T	DOMINANT	2.92E−05	2.92E−05	1.6406	1.6406	0.3945	0
  rs6550705	Imputed	C	ADDITIVE	8.91E−05	8.91E−05	1.3969	1.3969	0.7348	0
  rs6550705	Imputed	C	GENOTYPIC	5.30E−05	5.30E−05	2.0995	2.0995	0.9749	0
  rs6550707	Imputed	T	GENOTYPIC	7.67E−05	7.67E−05	2.0358	2.0358	0.8969	0
  rs658108	Imputed	A	DOMINANT	0.0002659	0.0002659	1.5304	1.5304	0.8231	0
  rs6593441	Imputed	A	DOMINANT	0.0002048	0.0002048	1.6724	1.6724	0.545	0
  rs668732	Imputed	A	DOMINANT	7.59E−05	7.59E−05	1.6958	1.6958	0.6376	0
  rs671041	Imputed	A	DOMINANT	0.0002098	0.0002098	1.5412	1.5412	0.8876	0
  rs6719700	Imputed	A	ADDITIVE	0.0005301	0.0005301	1.4892	1.4892	0.6569	0
  rs6719700	Imputed	A	DOMINANT	0.0009974	0.0009974	1.5282	1.5282	0.9621	0
  rs6722640	Imputed	T	DOMINANT	0.0001647	0.0001647	0.6343	0.6343	0.417	0
  rs6743092	Imputed	T	ADDITIVE	0.0002329	0.0002329	1.3618	1.3618	0.9832	0
  rs6743092	Imputed	T	GENOTYPIC	0.0002232	0.0002232	1.8571	1.8571	0.9791	0
  rs6743092	Imputed	T	RECESSIVE	0.001144	0.001144	1.5648	1.5648	0.9735	0
  rs6744759	Imputed	G	RECESSIVE	0.006086	0.006086	1.7637	1.7637	0.7956	0
  rs6746170	Imputed	A	DOMINANT	4.95E−05	4.95E−05	1.6166	1.6166	0.5054	0
  rs6759922	Imputed	A	DOMINANT	5.10E−05	5.10E−05	0.5892	0.5892	0.6074	0
  rs6769864	Imputed	T	GENOTYPIC	5.78E−05	5.78E−05	2.0921	2.0921	0.9627	0
  rs6773932	Imputed	C	GENOTYPIC	8.12E−05	8.12E−05	2.0503	2.0503	0.8139	0
  rs6774353	Imputed	A	GENOTYPIC	5.78E−05	5.78E−05	2.0921	2.0921	0.9627	0
  rs6781670	Imputed	C	GENOTYPIC	7.91E−05	7.91E−05	2.0683	2.0683	0.8608	0
  rs6786431	Imputed	A	GENOTYPIC	8.12E−05	8.12E−05	2.0503	2.0503	0.8139	0
  rs6789091	Imputed	T	GENOTYPIC	8.12E−05	8.12E−05	2.0503	2.0503	0.8139	0
  rs6791296	Imputed	T	ADDITIVE	0.0005376	0.0005376	0.6284	0.6284	0.9209	0
  rs6792662	Imputed	G	DOMINANT	0.0001499	0.0001499	1.7002	1.7002	0.4736	0
  rs6797574	Imputed	G	GENOTYPIC	8.12E−05	8.12E−05	2.0503	2.0503	0.8139	0
  rs6797882	Imputed	G	GENOTYPIC	7.58E−05	7.58E−05	2.0585	2.0585	0.8005	0
  rs6805139	Imputed	G	DOMINANT	0.0001083	0.0001083	1.6957	1.6957	0.5312	0
  rs6806043	Imputed	C	ADDITIVE	6.97E−05	6.97E−05	1.4041	1.4041	0.6772	0
  rs6806043	Imputed	C	GENOTYPIC	4.41E−05	4.41E−05	2.1162	2.1162	0.9314	0
  rs6850716	Imputed	C	GENOTYPIC	6.01E−05	6.01E−05	3.2642	3.2642	0.9641	0
  rs6867153	Imputed	A	RECESSIVE	3.66E−05	3.66E−05	0.5455	0.5455	0.7414	0
  rs687047	Imputed	C	ADDITIVE	0.001907	0.001907	0.6716	0.6716	0.7468	0
  rs6871041	Imputed	G	DOMINANT	0.0002601	0.0002601	0.6351	0.6351	0.5713	0
  rs688358	Imputed	A	ADDITIVE	0.001332	0.001332	0.6614	0.6614	0.8904	0
  rs6888012	Imputed	A	RECESSIVE	3.66E−05	3.66E−05	0.5455	0.5455	0.7414	0
  rs6908481	Imputed	C	RECESSIVE	8.53E−05	8.53E−05	1.8461	1.8461	0.6072	0
  rs7032231	Imputed	A	ADDITIVE	0.003089	0.004335	1.2986	1.3011	0.2989	7.33
  rs7067638	Imputed	T	DOMINANT	0.0002484	0.0002484	1.6722	1.6722	0.663	0
  rs7077799	Imputed	A	DOMINANT	0.0002066	0.0002066	1.5609	1.5609	0.6624	0
  rs7082163	Imputed	A	ADDITIVE	4.21E−05	4.21E−05	1.6619	1.6619	0.5882	0
  rs7082163	Imputed	A	DOMINANT	6.78E−05	6.78E−05	1.7473	1.7473	0.7157	0
  rs7089661	Imputed	C	DOMINANT	0.0001345	0.0001345	1.5612	1.5612	0.6665	0
  rs7101319	Imputed	C	ADDITIVE	5.11E−05	5.11E−05	1.6533	1.6533	0.5666	0
  rs7101319	Imputed	C	DOMINANT	8.45E−05	8.45E−05	1.7359	1.7359	0.6904	0
  rs710832	Genotyped	A	GENOTYPIC	0.0003218	0.0003218	0.3641	0.3641	0.5473	0
  rs710832	Genotyped	A	RECESSIVE	0.0001214	0.0001214	0.3456	0.3456	0.5387	0
  rs7134262	Imputed	T	GENOTYPIC	0.0005116	0.0005116	1.9228	1.9228	0.357	0
  rs7134262	Imputed	T	RECESSIVE	1.88E−05	0.0002297	2.1112	2.0864	0.2602	21.12
  rs7134671	Imputed	T	GENOTYPIC	8.82E−05	8.82E−05	1.9952	1.9952	0.3861	0
  rs7138300	Imputed	C	ADDITIVE	0.0004633	0.0004633	0.7392	0.7392	0.7118	0
  rs7138300	Imputed	C	DOMINANT	0.0002642	0.0002642	0.6285	0.6285	0.7714	0
  rs7138300	Imputed	C	GENOTYPIC	0.001515	0.001515	0.574	0.574	0.5208	0
  rs7163931	Imputed	G	GENOTYPIC	0.0001138	0.0001138	3.4509	3.4509	0.8527	0
  rs7163931	Imputed	G	RECESSIVE	0.0001586	0.0001586	3.317	3.317	0.9056	0
  rs7171486	Genotyped	G	DOMINANT	0.002255	0.00726	0.6976	0.69	0.2524	23.66
  rs7172611	Imputed	G	GENOTYPIC	0.0001106	0.0001106	3.4591	3.4591	0.8474	0
  rs7172611	Imputed	G	RECESSIVE	0.0001586	0.0001586	3.317	3.317	0.9056	0
  rs7172689	Imputed	T	GENOTYPIC	0.0001106	0.0001106	3.4591	3.4591	0.8474	0
  rs7172689	Imputed	T	RECESSIVE	0.0001586	0.0001586	3.317	3.317	0.9056	0
  rs7175701	Imputed	C	GENOTYPIC	0.0002485	0.0002485	2.9103	2.9103	0.9903	0
  rs7180245	Imputed	A	GENOTYPIC	0.0001106	0.0001106	3.4591	3.4591	0.8474	0
  rs7180245	Imputed	A	RECESSIVE	0.0001586	0.0001586	3.317	3.317	0.9056	0
  rs7220603	Genotyped	A	ADDITIVE	6.15E−05	6.15E−05	0.6874	0.6874	0.5095	0
  rs7282518	Imputed	T	ADDITIVE	4.72E−05	4.72E−05	1.6157	1.6157	0.6576	0
  rs7283476	Imputed	T	ADDITIVE	0.001444	0.002668	0.4528	0.4555	0.2951	8.76
  rs7283476	Imputed	T	DOMINANT	0.001188	0.01352	0.4307	0.4432	0.213	35.52
  rs7295817	Imputed	C	GENOTYPIC	0.001617	0.007423	0.5763	0.5838	0.2587	21.63
  rs7298255	Imputed	A	ADDITIVE	0.0004959	0.0004959	0.7441	0.7441	0.8645	0
  rs7298255	Imputed	A	DOMINANT	0.0001567	0.0001567	0.6197	0.6197	0.8009	0
  rs7305832	Imputed	C	GENOTYPIC	0.0004601	0.0004601	1.9292	1.9292	0.3332	0
  rs7305832	Imputed	C	RECESSIVE	1.85E−05	0.0003707	2.1109	2.0804	0.2465	25.55
  rs7331467	Imputed	A	GENOTYPIC	8.27E−05	8.27E−05	2.0747	2.0747	0.9516	0
  rs7392620	Imputed	C	ADDITIVE	0.003409	0.003409	0.7677	0.7677	0.844	0
  rs742827	Imputed	A	ADDITIVE	0.0001374	0.0001374	1.3962	1.3962	0.8859	0
  rs742827	Imputed	A	GENOTYPIC	0.0002152	0.0002152	1.9872	1.9872	0.5834	0
  rs742827	Imputed	A	RECESSIVE	0.001964	0.001964	1.6988	1.6988	0.3688	0
  rs7446891	Imputed	G	DOMINANT	0.000699	0.000699	0.6712	0.6712	0.8706	0
  rs7448641	Imputed	C	ADDITIVE	1.27E−05	1.27E−05	0.2451	0.2451	0.6218	0
  rs7448641	Imputed	C	DOMINANT	2.81E−05	2.81E−05	0.2509	0.2509	0.6535	0
  rs7484728	Imputed	T	GENOTYPIC	8.08E−05	8.08E−05	2.0019	2.0019	0.395	0
  rs7499402	Genotyped	A	ADDITIVE	0.001818	0.001818	1.6071	1.6071	0.4709	0
  rs7529851	Imputed	A	ADDITIVE	0.0007167	0.0007351	0.7475	0.7475	0.3163	0.4
  rs7529851	Imputed	A	GENOTYPIC	0.0007339	0.0007339	0.5463	0.5463	0.4438	0
  rs7573951	Imputed	G	ADDITIVE	7.56E−05	7.56E−05	0.7086	0.7086	0.8496	0
  rs7599198	Imputed	T	DOMINANT	9.29E−05	9.29E−05	0.5939	0.5939	0.6564	0
  rs7600050	Imputed	C	ADDITIVE	0.000398	0.000398	1.3671	1.3671	0.401	0
  rs7607712	Imputed	T	ADDITIVE	0.0003189	0.0003189	1.452	1.452	0.6392	0
  rs7607712	Imputed	T	DOMINANT	0.0007082	0.0007082	1.5005	1.5005	0.8593	0
  rs7613492	Imputed	G	GENOTYPIC	5.46E−05	5.46E−05	2.1046	2.1046	0.983	0
  rs7621663	Imputed	G	ADDITIVE	5.19E−05	5.19E−05	1.4264	1.4264	0.8945	0
  rs7621663	Imputed	G	GENOTYPIC	1.68E−05	1.68E−05	2.2926	2.2926	0.7204	0
  rs7621663	Imputed	G	RECESSIVE	8.03E−05	8.03E−05	2.0424	2.0424	0.5218	0
  rs7626584	Imputed	G	ADDITIVE	0.000166	0.000166	0.5017	0.5017	0.6498	0
  rs7684899	Imputed	C	ADDITIVE	0.001935	0.001935	0.7236	0.7236	0.8673	0
  rs7684899	Imputed	C	DOMINANT	0.000396	0.000396	0.6536	0.6536	0.8664	0
  rs7701604	Imputed	G	ADDITIVE	1.27E−05	1.27E−05	0.2451	0.2451	0.6218	0
  rs7701604	Imputed	G	DOMINANT	2.81E−05	2.81E−05	0.2509	0.2509	0.6535	0
  rs7703676	Imputed	C	ADDITIVE	1.27E−05	1.27E−05	0.2451	0.2451	0.6218	0
  rs7703676	Imputed	C	DOMINANT	2.81E−05	2.81E−05	0.2509	0.2509	0.6535	0
  rs7708491	Imputed	C	RECESSIVE	6.44E−05	6.44E−05	0.5582	0.5582	0.823	0
  rs7711358	Imputed	A	DOMINANT	0.0005772	0.0005772	0.6679	0.6679	0.7414	0
  rs7719448	Imputed	G	RECESSIVE	3.03E−05	3.03E−05	0.5422	0.5422	0.7436	0
  rs7724761	Imputed	T	RECESSIVE	2.79E−05	2.79E−05	0.5376	0.5376	0.8521	0
  rs7742476	Imputed	T	DOMINANT	9.96E−05	9.96E−05	1.6177	1.6177	0.3946	0
  rs7762993	Imputed	A	ADDITIVE	9.68E−05	9.68E−05	1.5062	1.5062	0.5789	0
  rs7762993	Imputed	A	DOMINANT	1.55E−05	1.55E−05	1.6955	1.6955	0.475	0
  rs7767265	Imputed	G	ADDITIVE	1.02E−05	1.02E−05	1.5369	1.5369	0.4161	0
  rs7767265	Imputed	G	DOMINANT	1.30E−06	1.30E−06	1.786	1.786	0.4646	0
  rs7768128	Imputed	G	RECESSIVE	0.001331	0.001331	0.4131	0.4131	0.6812	0
  rs7771264	Imputed	T	DOMINANT	6.68E−05	6.68E−05	0.6186	0.6186	0.338	0
  rs7773151	Genotyped	C	DOMINANT	7.51E−05	7.51E−05	0.624	0.624	0.3194	0
  rs7773210	Genotyped	A	DOMINANT	6.11E−05	6.11E−05	0.6205	0.6205	0.3365	0
  rs7808536	Imputed	G	DOMINANT	0.0002477	0.003942	1.5602	1.593	0.1988	39.43
  rs7843510	Genotyped	G	DOMINANT	9.47E−05	9.47E−05	1.6156	1.6156	0.9612	0
  rs7894867	Imputed	T	DOMINANT	0.0002327	0.0002327	1.6763	1.6763	0.6457	0
  rs7921834	Imputed	C	DOMINANT	0.0001474	0.0001474	1.5574	1.5574	0.6777	0
  rs7939893	Imputed	C	ADDITIVE	0.001994	0.001994	0.7672	0.7672	0.4917	0
  rs7939893	Imputed	C	DOMINANT	0.00178	0.00178	0.6939	0.6939	0.7543	0
  rs7944513	Imputed	T	GENOTYPIC	3.70E−05	3.70E−05	3.1057	3.1057	0.4987	0
  rs7944513	Imputed	T	RECESSIVE	6.05E−05	6.05E−05	2.9509	2.9509	0.4009	0
  rs7949720	Imputed	G	ADDITIVE	6.02E−05	6.02E−05	0.5917	0.5917	0.6951	0
  rs7949720	Imputed	G	DOMINANT	4.34E−05	4.34E−05	0.5526	0.5526	0.5364	0
  rs7955901	Imputed	C	ADDITIVE	0.0005679	0.0005679	0.745	0.745	0.8856	0
  rs7955901	Imputed	C	DOMINANT	0.0002109	0.0002109	0.6246	0.6246	0.7241	0
  rs7956274	Imputed	T	ADDITIVE	0.000471	0.000471	0.7423	0.7423	0.7644	0
  rs7956274	Imputed	T	DOMINANT	0.0001278	0.0001278	0.6144	0.6144	0.9458	0
  rs7956274	Imputed	T	GENOTYPIC	0.001643	0.001643	0.582	0.582	0.6004	0
  rs7957932	Imputed	G	ADDITIVE	0.001051	0.001051	0.7578	0.7578	0.8972	0
  rs7957932	Imputed	G	DOMINANT	0.0001397	0.0001397	0.6136	0.6136	0.8447	0
  rs7984504	Imputed	C	GENOTYPIC	9.33E−05	9.33E−05	2.1895	2.1895	0.8871	0
  rs7999518	Imputed	A	RECESSIVE	0.003293	0.003293	0.6449	0.6449	0.9164	0
  rs8026245	Imputed	G	GENOTYPIC	0.0001769	0.0001769	3.0849	3.0849	0.8542	0
  rs8026245	Imputed	G	RECESSIVE	0.0001739	0.0001739	3.0436	3.0436	0.9473	0
  rs8060725	Genotyped	A	ADDITIVE	0.001967	0.001967	0.7414	0.7414	0.74	0
  rs8103016	Genotyped	A	ADDITIVE	1.97E−05	1.97E−05	1.5542	1.5542	0.8792	0
  rs8103016	Genotyped	A	DOMINANT	5.37E−05	5.37E−05	1.6315	1.6315	0.8495	0
  rs8104182	Imputed	G	ADDITIVE	8.91E−05	8.91E−05	1.5032	1.5032	0.628	0
  rs8104182	Imputed	G	DOMINANT	0.000187	0.000187	1.5764	1.5764	0.6041	0
  rs8129461	Imputed	G	ADDITIVE	0.001444	0.002668	0.4528	0.4555	0.2951	8.76
  rs8129461	Imputed	G	DOMINANT	0.001188	0.01352	0.4307	0.4432	0.213	35.52
  rs8130021	Imputed	G	ADDITIVE	0.001444	0.002668	0.4528	0.4555	0.2951	8.76
  rs8130021	Imputed	G	DOMINANT	0.001188	0.01352	0.4307	0.4432	0.213	35.52
  rs879961	Imputed	T	ADDITIVE	2.33E−05	2.33E−05	0.6659	0.6659	0.4449	0
  rs879961	Imputed	T	DOMINANT	1.51E−05	1.51E−05	0.6005	0.6005	0.9844	0
  rs906353	Imputed	A	DOMINANT	9.95E−05	9.95E−05	0.6352	0.6352	0.8067	0
  rs915491	Imputed	C	DOMINANT	0.0002054	0.0002054	1.5426	1.5426	0.7028	0
  rs915493	Imputed	T	DOMINANT	0.0002054	0.0002054	1.5426	1.5426	0.7028	0
  rs915494	Imputed	A	ADDITIVE	0.001238	0.001238	1.3527	1.3527	0.6764	0
  rs915494	Imputed	A	DOMINANT	0.0002045	0.0002045	1.5574	1.5574	0.5538	0
  rs917295	Imputed	G	DOMINANT	0.0005579	0.0005579	0.6664	0.6664	0.9359	0
  rs9284851	Imputed	A	GENOTYPIC	6.86E−05	6.86E−05	2.0519	2.0519	0.9886	0
  rs9293464	Imputed	T	RECESSIVE	3.03E−05	3.03E−05	0.5422	0.5422	0.7436	0
  rs9295154	Genotyped	G	DOMINANT	0.0003436	0.0007175	1.5908	1.5981	0.2899	10.73
  rs9310221	Imputed	A	DOMINANT	6.72E−05	6.93E−05	1.6779	1.6777	0.3166	0.28
  rs9310699	Genotyped	T	GENOTYPIC	7.91E−05	7.91E−05	2.0683	2.0683	0.8608	0
  rs9310700	Imputed	C	ADDITIVE	8.64E−05	8.64E−05	1.4077	1.4077	0.7999	0
  rs9310700	Imputed	C	GENOTYPIC	3.31E−05	3.31E−05	2.2015	2.2015	0.8601	0
  rs9310701	Imputed	G	GENOTYPIC	7.67E−05	7.67E−05	2.0358	2.0358	0.8969	0
  rs9310704	Imputed	G	GENOTYPIC	4.87E−05	4.87E−05	2.1011	2.1011	0.908	0
  rs9319185	Imputed	C	GENOTYPIC	5.38E−05	5.38E−05	2.2836	2.2836	0.9842	0
  rs9319186	Imputed	T	GENOTYPIC	7.93E−05	7.93E−05	2.2431	2.2431	0.9603	0
  rs9327555	Imputed	T	DOMINANT	0.000699	0.000699	0.6712	0.6712	0.8706	0
  rs9403367	Imputed	C	DOMINANT	6.11E−05	6.11E−05	0.6205	0.6205	0.3365	0
  rs9419608	Imputed	G	RECESSIVE	4.08E−05	4.08E−05	1.7425	1.7425	0.608	0
  rs9426437	Imputed	T	DOMINANT	5.00E−05	5.00E−05	0.607	0.607	0.4632	0
  rs9454967	Imputed	G	DOMINANT	5.94E−05	5.94E−05	1.9576	1.9576	0.6125	0
  rs9635511	Imputed	T	DOMINANT	7.73E−05	7.73E−05	0.618	0.618	0.4399	0
  rs966583	Imputed	A	ADDITIVE	9.56E−05	9.56E−05	0.7127	0.7127	0.7413	0
  rs966583	Imputed	A	DOMINANT	4.65E−05	4.65E−05	0.6082	0.6082	0.9923	0
  rs980263	Imputed	T	GENOTYPIC	6.16E−05	6.16E−05	2.059	2.059	0.935	0
  rs980264	Imputed	T	GENOTYPIC	6.16E−05	6.16E−05	2.059	2.059	0.935	0
  rs9812206	Imputed	G	ADDITIVE	5.80E−06	5.80E−06	0.5122	0.5122	0.7976	0
  rs9812206	Imputed	G	DOMINANT	4.29E−06	4.29E−06	0.4876	0.4876	0.9796	0
  rs9813552	Imputed	G	ADDITIVE	4.13E−05	4.13E−05	0.5495	0.5495	0.7178	0
  rs9813552	Imputed	G	DOMINANT	3.19E−05	3.19E−05	0.5265	0.5265	0.9286	0
  rs9815037	Imputed	T	ADDITIVE	1.99E−05	1.99E−05	0.5261	0.5261	0.5342	0
  rs9815037	Imputed	T	DOMINANT	1.13E−05	1.13E−05	0.4982	0.4982	0.7438	0
  rs9819583	Imputed	T	GENOTYPIC	7.12E−05	7.12E−05	2.0778	2.0778	0.8761	0
  rs9825349	Imputed	A	ADDITIVE	1.98E−05	1.98E−05	0.5259	0.5259	0.5483	0
  rs9825349	Imputed	A	DOMINANT	1.13E−05	1.13E−05	0.4982	0.4982	0.7598	0
  rs9833118	Imputed	G	ADDITIVE	9.63E−05	9.63E−05	1.3977	1.3977	0.6136	0
  rs9833118	Imputed	G	GENOTYPIC	5.01E−05	5.01E−05	2.1101	2.1101	0.8729	0
  rs9834217	Imputed	T	ADDITIVE	2.21E−05	2.21E−05	0.5279	0.5279	0.5562	0
  rs9834217	Imputed	T	DOMINANT	1.26E−05	1.26E−05	0.5002	0.5002	0.7692	0
  rs9838563	Imputed	C	GENOTYPIC	7.67E−05	7.67E−05	2.0358	2.0358	0.8969	0
  rs9840460	Imputed	T	ADDITIVE	2.08E−05	2.08E−05	0.5268	0.5268	0.5431	0
  rs9840460	Imputed	T	DOMINANT	1.18E−05	1.18E−05	0.499	0.499	0.7541	0
  rs9840756	Imputed	A	ADDITIVE	2.08E−05	2.08E−05	0.5268	0.5268	0.5431	0
  rs9840756	Imputed	A	DOMINANT	1.18E−05	1.18E−05	0.499	0.499	0.7541	0
  rs9847999	Imputed	C	GENOTYPIC	9.15E−05	9.15E−05	2.0254	2.0254	0.9674	0
  rs9864769	Imputed	C	GENOTYPIC	7.67E−05	7.67E−05	2.0358	2.0358	0.8969	0
  rs9866421	Genotyped	C	RECESSIVE	0.0009027	0.0009027	0.6009	0.6009	0.4635	0
  rs987296	Imputed	T	GENOTYPIC	7.90E−05	7.90E−05	2.0683	2.0683	0.8607	0
  rs9881685	Imputed	A	ADDITIVE	5.80E−06	5.80E−06	0.5122	0.5122	0.7976	0
  rs9881685	Imputed	A	DOMINANT	4.29E−06	4.29E−06	0.4876	0.4876	0.9796	0
  rs992695	Imputed	C	ADDITIVE	2.92E−05	2.92E−05	0.6695	0.6695	0.4384	0
  rs992695	Imputed	C	DOMINANT	2.06E−05	2.06E−05	0.6059	0.6059	0.9952	0
  rs9936999	Imputed	G	DOMINANT	8.52E−05	8.52E−05	1.8486	1.8486	0.8612	0

• TABLE 18
  SNP rs #	SOURCE	ALLELE (A1)	MODEL	P	P(R)	OR	OR(R)	Q	I

  rs77638540	Genotyped	T	DOMINANT	8.53E−05	8.53E−05	0.4412	0.4412	0.4473	0
  rs72746987	Genotyped	A	DOMINANT	1.04E−03	0.07511	0.5034	0.4987	0.037	69.66
  rs10021016	Genotyped	G	GENOTYPIC	1.77E−05	1.77E−05	2.4195	2.4195	0.946	0
  rs10021016	Genotyped	G	RECESSIVE	3.95E−05	3.95E−05	2.2819	2.2819	0.9639	0
  rs10051148	Imputed	C	DOMINANT	4.37E−05	4.37E−05	0.663	0.663	0.936	0
  rs10054055	Imputed	T	DOMINANT	2.45E−05	2.45E−05	0.652	0.652	0.8092	0
  rs10067895	Imputed	A	DOMINANT	2.54E−05	2.54E−05	0.6504	0.6504	0.7871	0
  rs10100725	Imputed	C	DOMINANT	9.58E−04	0.1048	0.6943	0.7246	0.0468	67.33
  rs10128531	Imputed	T	ADDITIVE	6.93E−05	6.93E−05	1.5153	1.5153	0.8693	0
  rs10181743	Imputed	G	ADDITIVE	1.45E−04	7.58E−04	1.3254	1.3179	0.3011	16.69
  rs10199127	Imputed	T	DOMINANT	3.21E−04	0.02399	1.4423	1.433	0.098	56.95
  rs10270624	Imputed	G	DOMINANT	7.89E−05	7.89E−05	1.5242	1.5242	0.5064	0
  rs1030006	Imputed	G	RECESSIVE	2.14E−03	0.1294	1.4544	1.4242	0.0332	70.63
  rs1031811	Imputed	A	RECESSIVE	8.78E−05	8.78E−05	1.988	1.988	0.5276	0
  rs10430870	Genotyped	G	GENOTYPIC	6.56E−05	6.56E−05	2.3812	2.3812	0.4518	0
  rs10430870	Genotyped	G	RECESSIVE	9.42E−05	9.42E−05	2.2976	2.2976	0.5059	0
  rs10469597	Imputed	A	GENOTYPIC	2.56E−04	7.98E−03	2.0793	2.008	0.1981	38.23
  rs10469597	Imputed	A	RECESSIVE	1.31E−04	3.67E−04	2.1038	2.0871	0.3313	9.47
  rs10478919	Imputed	G	DOMINANT	1.88E−05	1.88E−05	0.6481	0.6481	0.8316	0
  rs10506623	Imputed	C	ADDITIVE	3.33E−05	3.33E−05	0.7343	0.7343	0.8201	0
  rs10506623	Imputed	C	DOMINANT	2.58E−05	2.58E−05	0.6418	0.6418	0.8101	0
  rs10506626	Imputed	A	ADDITIVE	1.01E−05	1.01E−05	0.7226	0.7226	0.6798	0
  rs10506626	Imputed	A	DOMINANT	1.59E−06	1.59E−06	0.608	0.608	0.7968	0
  rs10509477	Imputed	T	DOMINANT	2.98E−05	2.98E−05	1.5214	1.5214	0.7093	0
  rs10517918	Imputed	G	RECESSIVE	6.32E−04	0.04182	1.5595	1.5312	0.0872	59.01
  rs10517924	Imputed	A	RECESSIVE	3.69E−04	0.007266	1.5408	1.514	0.2104	35.84
  rs10519362	Imputed	G	DOMINANT	9.95E−05	9.95E−05	1.5338	1.5338	0.9176	0
  rs10520072	Imputed	T	DOMINANT	1.82E−05	1.82E−05	0.647	0.647	0.881	0
  rs10737390	Imputed	T	DOMINANT	1.26E−03	1.43E−01	0.7118	0.7485	0.0363	69.84
  rs10742851	Imputed	T	RECESSIVE	1.44E−02	3.23E−01	0.5988	0.593	0.0033	82.54
  rs10743685	Imputed	G	GENOTYPIC	4.32E−05	4.32E−05	1.8534	1.8534	0.6642	0
  rs10743685	Imputed	G	RECESSIVE	7.41E−05	7.41E−05	1.7214	1.7214	0.6436	0
  rs10749293	Imputed	G	DOMINANT	1.17E−05	1.17E−05	1.5526	1.5526	0.866	0
  rs10749294	Imputed	A	DOMINANT	6.69E−05	6.69E−05	1.4909	1.4909	0.8006	0
  rs10753760	Imputed	T	ADDITIVE	1.83E−03	1.26E−01	1.2546	1.2395	0.0287	71.84
  rs10753760	Imputed	T	GENOTYPIC	2.08E−03	1.35E−01	1.5862	1.5469	0.0269	72.33
  rs10772362	Imputed	T	ADDITIVE	2.16E−05	2.16E−05	0.691	0.691	0.4243	0
  rs10784891	Imputed	C	ADDITIVE	3.13E−05	3.13E−05	0.7354	0.7354	0.9449	0
  rs10784891	Imputed	C	DOMINANT	6.41E−05	6.41E−05	0.6454	0.6454	0.7393	0
  rs10784891	Imputed	C	GENOTYPIC	9.84E−05	9.84E−05	0.5575	0.5575	0.8437	0
  rs10787923	Imputed	G	DOMINANT	1.08E−05	1.08E−05	1.556	1.556	0.8555	0
  rs10787924	Imputed	T	DOMINANT	5.94E−05	5.94E−05	1.4953	1.4953	0.7873	0
  rs10787949	Imputed	A	DOMINANT	5.22E−05	5.22E−05	1.503	1.503	0.7135	0
  rs10787951	Imputed	G	DOMINANT	5.35E−05	5.35E−05	1.5021	1.5021	0.7092	0
  rs10787983	Imputed	C	DOMINANT	5.23E−05	5.23E−05	1.5007	1.5007	0.7558	0
  rs10794733	Imputed	C	ADDITIVE	7.05E−05	7.05E−05	0.7343	0.7343	0.7115	0
  rs10818280	Imputed	C	DOMINANT	9.18E−05	9.18E−05	0.6734	0.6734	0.8782	0
  rs10860586	Imputed	A	ADDITIVE	3.08E−03	0.1633	1.2361	1.2211	0.0224	73.69
  rs10860586	Imputed	A	GENOTYPIC	3.00E−03	1.63E−01	1.5291	1.4908	0.0225	73.63
  rs10870473	Imputed	A	ADDITIVE	3.61E−03	2.33E−01	0.6941	0.7378	0.0195	74.59
  rs10870473	Imputed	A	DOMINANT	5.37E−03	4.68E−01	0.6441	0.7381	0.0016	84.48
  rs10879240	Imputed	C	ADDITIVE	3.83E−05	3.83E−05	0.74	0.74	0.9636	0
  rs10879240	Imputed	C	GENOTYPIC	9.34E−05	9.34E−05	0.5585	0.5585	0.7993	0
  rs10879242	Imputed	A	ADDITIVE	4.26E−05	4.26E−05	0.7384	0.7384	0.8941	0
  rs10879242	Imputed	A	DOMINANT	2.29E−05	2.29E−05	0.6402	0.6402	0.8341	0
  rs10879245	Imputed	G	ADDITIVE	4.26E−05	4.26E−05	0.7384	0.7384	0.8941	0
  rs10879245	Imputed	G	DOMINANT	2.29E−05	2.29E−05	0.6402	0.6402	0.8341	0
  rs10879249	Imputed	T	ADDITIVE	2.01E−05	2.01E−05	0.7287	0.7287	0.7861	0
  rs10879249	Imputed	T	DOMINANT	1.30E−05	1.30E−05	0.6335	0.6335	0.7421	0
  rs10886429	Imputed	A	DOMINANT	6.44E−05	6.44E−05	1.4958	1.4958	0.6357	0
  rs10886449	Imputed	G	DOMINANT	8.67E−05	8.67E−05	1.4833	1.4833	0.761	0
  rs10886451	Imputed	G	DOMINANT	8.67E−05	8.67E−05	1.4833	1.4833	0.761	0
  rs10886452	Imputed	A	DOMINANT	4.28E−05	4.28E−05	1.5097	1.5097	0.7458	0
  rs10886456	Imputed	G	DOMINANT	8.67E−05	8.67E−05	1.4833	1.4833	0.761	0
  rs10886463	Imputed	C	DOMINANT	5.51E−05	5.51E−05	1.5014	1.5014	0.737	0
  rs10886465	Imputed	A	DOMINANT	3.16E−05	3.16E−05	1.5202	1.5202	0.6725	0
  rs10886526	Imputed	C	DOMINANT	4.73E−05	4.73E−05	1.5047	1.5047	0.7756	0
  rs10922903	Imputed	C	RECESSIVE	7.51E−04	0.04061	0.6326	0.6533	0.1055	55.53
  rs10941126	Imputed	G	ADDITIVE	2.88E−03	0.1046	0.5269	0.4225	0.0055	80.81
  rs10941126	Imputed	G	DOMINANT	5.93E−03	0.1502	0.5204	0.4449	0.0058	80.6
  rs10947980	Imputed	G	ADDITIVE	0.0007135	0.04303	0.7602	0.7647	0.0779	60.82
  rs11059376	Imputed	T	ADDITIVE	2.09E−04	2.16E−03	1.4335	1.4217	0.2602	25.72
  rs11072995	Imputed	T	GENOTYPIC	5.56E−05	5.56E−05	2.911	2.911	0.7416	0
  rs11072995	Imputed	T	RECESSIVE	8.05E−05	8.05E−05	2.8127	2.8127	0.7514	0
  rs11081202	Genotyped	G	GENOTYPIC	4.78E−05	4.78E−05	2.2039	2.2039	0.4315	0
  rs11081202	Genotyped	G	RECESSIVE	9.57E−06	9.57E−06	2.3008	2.3008	0.5359	0
  rs110965	Imputed	C	GENOTYPIC	5.25E−05	5.42E−05	2.0397	2.04	0.3665	0.36
  rs11124962	Imputed	A	DOMINANT	9.31E−05	9.31E−05	1.4868	1.4868	0.434	0
  rs1116596	Imputed	T	DOMINANT	2.21E−05	2.21E−05	0.6501	0.6501	0.8309	0
  rs11178531	Imputed	A	ADDITIVE	8.31E−05	8.31E−05	0.753	0.753	0.9192	0
  rs11178531	Imputed	A	DOMINANT	4.55E−05	4.55E−05	0.64	0.64	0.9035	0
  rs11178583	Imputed	A	ADDITIVE	2.33E−05	2.33E−05	0.7308	0.7308	0.7646	0
  rs11178583	Imputed	A	DOMINANT	1.65E−05	1.65E−05	0.6373	0.6373	0.7197	0
  rs11178589	Imputed	T	ADDITIVE	1.62E−05	1.62E−05	0.7264	0.7264	0.7893	0
  rs11178589	Imputed	T	DOMINANT	1.26E−05	1.26E−05	0.6312	0.6312	0.7472	0
  rs11178594	Imputed	C	ADDITIVE	2.03E−05	2.03E−05	0.7297	0.7297	0.8443	0
  rs11178594	Imputed	C	DOMINANT	1.05E−05	1.05E−05	0.6313	0.6313	0.8109	0
  rs11178602	Imputed	T	ADDITIVE	1.67E−05	1.67E−05	0.7273	0.7273	0.8496	0
  rs11178602	Imputed	T	DOMINANT	7.52E−06	7.52E−06	0.6264	0.6264	0.7997	0
  rs11178648	Imputed	T	ADDITIVE	2.57E−05	2.57E−05	0.7339	0.7339	0.8706	0
  rs11178648	Imputed	T	DOMINANT	3.00E−06	3.00E−06	0.6155	0.6155	0.8521	0
  rs11198877	Imputed	T	DOMINANT	4.14E−05	4.14E−05	1.5107	1.5107	0.7435	0
  rs11198942	Imputed	T	DOMINANT	2.98E−05	2.98E−05	1.5214	1.5214	0.7093	0
  rs11221075	Imputed	A	ADDITIVE	4.53E−05	4.53E−05	0.6241	0.6241	0.5015	0
  rs11242020	Imputed	T	DOMINANT	1.95E−05	1.95E−05	0.6485	0.6485	0.8129	0
  rs11242021	Imputed	T	DOMINANT	2.31E−05	2.31E−05	0.6505	0.6505	0.8585	0
  rs11242022	Imputed	T	DOMINANT	2.55E−05	2.55E−05	0.6519	0.6519	0.8477	0
  rs11242023	Imputed	T	DOMINANT	3.12E−05	3.12E−05	0.6547	0.6547	0.8417	0
  rs1149349	Imputed	T	DOMINANT	0.0001762	0.0002852	1.5177	1.5147	0.3503	4.68
  rs1149350	Imputed	A	ADDITIVE	0.004059	0.341	1.2908	1.2455	0.0015	84.55
  rs1149350	Imputed	A	DOMINANT	2.56E−04	1.03E−01	1.4706	1.4199	0.0201	74.39
  rs11576627	Imputed	T	ADDITIVE	3.90E−05	3.90E−05	1.5393	1.5393	0.6597	0
  rs11576627	Imputed	T	DOMINANT	2.57E−05	2.57E−05	1.6368	1.6368	0.6902	0
  rs11630050	Imputed	G	GENOTYPIC	7.79E−05	7.79E−05	2.665	2.665	0.6771	0
  rs11630050	Imputed	G	RECESSIVE	8.54E−05	8.54E−05	2.6107	2.6107	0.6577	0
  rs11633024	Imputed	C	GENOTYPIC	7.79E−05	7.79E−05	2.665	2.665	0.6771	0
  rs11633024	Imputed	C	RECESSIVE	8.54E−05	8.54E−05	2.6107	2.6107	0.6577	0
  rs11636298	Imputed	G	GENOTYPIC	4.65E−05	4.65E−05	2.9093	2.9093	0.6341	0
  rs11636298	Imputed	G	RECESSIVE	7.67E−05	7.67E−05	2.7833	2.7833	0.6295	0
  rs11637363	Imputed	C	GENOTYPIC	4.03E−05	4.03E−05	2.7783	2.7783	0.6785	0
  rs11637363	Imputed	C	RECESSIVE	4.23E−05	4.23E−05	2.7253	2.7253	0.6672	0
  rs11637813	Imputed	A	GENOTYPIC	7.79E−05	7.79E−05	2.665	2.665	0.6771	0
  rs11637813	Imputed	A	RECESSIVE	8.54E−05	8.54E−05	2.6107	2.6107	0.6577	0
  rs11638043	Imputed	C	GENOTYPIC	6.02E−05	6.02E−05	2.6802	2.6802	0.7627	0
  rs11638043	Imputed	C	RECESSIVE	6.43E−05	6.43E−05	2.6274	2.6274	0.7406	0
  rs11638115	Imputed	A	GENOTYPIC	5.56E−05	5.56E−05	2.911	2.911	0.7416	0
  rs11638115	Imputed	A	RECESSIVE	8.05E−05	8.05E−05	2.8127	2.8127	0.7514	0
  rs11638444	Imputed	C	GENOTYPIC	8.18E−05	8.18E−05	2.781	2.781	0.5241	0
  rs11682946	Imputed	A	ADDITIVE	2.15E−05	2.15E−05	4.6724	4.6724	0.6013	0
  rs11682946	Imputed	A	DOMINANT	2.84E−05	2.84E−05	4.7413	4.7413	0.5763	0
  rs11717157	Imputed	T	ADDITIVE	3.66E−04	4.28E−03	1.3013	1.2939	0.2362	30.7
  rs11717157	Imputed	T	GENOTYPIC	4.70E−04	0.02682	1.7552	1.6884	0.1274	51.46
  rs11724055	Imputed	A	DOMINANT	5.58E−05	5.58E−05	0.6449	0.6449	0.4625	0
  rs11743355	Imputed	C	ADDITIVE	3.93E−03	1.07E−01	0.5325	0.414	0.005	81.12
  rs11743355	Imputed	C	DOMINANT	7.85E−03	1.52E−01	0.5256	0.4354	0.0052	80.99
  rs11746806	Imputed	T	ADDITIVE	2.88E−03	1.05E−01	0.5269	0.4225	0.0055	80.81
  rs11746806	Imputed	T	DOMINANT	5.93E−03	1.50E−01	0.520	40.4449	0.0058	80.6
  rs11746959	Imputed	T	ADDITIVE	2.88E−03	0.1046	0.5269	0.4225	0.0055	80.81
  rs11746959	Imputed	T	DOMINANT	5.93E−03	1.50E−01	0.5204	0.4449	0.0058	80.6
  rs11749272	Imputed	T	DOMINANT	1.88E−05	1.88E−05	0.6481	0.6481	0.8316	0
  rs11839636	Imputed	C	GENOTYPIC	3.90E−03	2.09E−01	1.6569	1.5719	0.0165	75.65
  rs11839785	Imputed	C	GENOTYPIC	4.03E−03	2.10E−01	1.6541	1.57	0.0167	75.56
  rs11853619	Imputed	C	GENOTYPIC	5.35E−05	5.35E−05	2.8832	2.8832	0.6237	0
  rs11853619	Imputed	C	RECESSIVE	8.59E−05	8.59E−05	2.7639	2.7639	0.6266	0
  rs11856780	Imputed	A	GENOTYPIC	5.35E−05	5.35E−05	2.8832	2.8832	0.6237	0
  rs11856780	Imputed	A	RECESSIVE	8.59E−05	8.59E−05	2.7639	2.7639	0.6266	0
  rs11901899	Imputed	A	DOMINANT	5.52E−05	5.52E−05	1.5083	1.5083	0.5339	0
  rs11903290	Imputed	C	RECESSIVE	9.00E−05	9.00E−05	1.9859	1.9859	0.5245	0
  rs11909480	Imputed	G	ADDITIVE	9.50E−05	9.50E−05	0.4368	0.4368	0.6169	0
  rs11909480	Imputed	G	DOMINANT	7.23E−05	7.23E−05	0.418	0.418	0.5676	0
  rs11910289	Imputed	T	ADDITIVE	8.16E−05	8.16E−05	1.8423	1.8423	0.8017	0
  rs11910289	Imputed	T	DOMINANT	9.10E−05	9.10E−05	1.904	1.904	0.8708	0
  rs11920375	Genotyped	C	GENOTYPIC	7.95E−04	4.33E−02	1.703	1.6282	0.1117	54.37
  rs11926319	Imputed	G	DOMINANT	7.96E−04	0.02707	0.6352	0.6499	0.1381	49.5
  rs11933744	Imputed	T	RECESSIVE	3.12E−03	0.1216	1.7872	1.8072	0.0315	71.09
  rs11934919	Imputed	C	RECESSIVE	3.17E−03	0.1247	1.7868	1.804	0.0307	71.3
  rs11934957	Imputed	C	RECESSIVE	3.17E−03	0.1247	1.7868	1.804	0.0307	71.3
  rs11959206	Imputed	A	RECESSIVE	1.87E−03	0.191	0.678	0.7117	0.0177	75.21
  rs12038613	Imputed	C	RECESSIVE	3.47E−04	0.01168	0.613	0.6271	0.1717	43.24
  rs12151417	Imputed	T	DOMINANT	6.25E−05	6.25E−05	1.506	1.506	0.9573	0
  rs12153185	Imputed	T	DOMINANT	2.47E−05	2.47E−05	0.6504	0.6504	0.757	0
  rs12182651	Imputed	T	DOMINANT	8.64E−04	5.43E−02	1.5996	1.5843	0.071	62.2
  rs12235345	Imputed	C	DOMINANT	6.65E−05	6.65E−05	1.8285	1.8285	0.4602	0
  rs12324786	Imputed	T	GENOTYPIC	5.56E−05	5.56E−05	2.911	2.911	0.7416	0
  rs12324786	Imputed	T	RECESSIVE	8.05E−05	8.05E−05	2.8127	2.8127	0.7514	0
  rs12336958	Imputed	G	DOMINANT	4.62E−03	2.90E−01	1.3599	1.2903	0.009	78.77
  rs12407412	Imputed	C	ADDITIVE	4.55E−05	4.55E−05	1.5333	1.5333	0.6371	0
  rs12407412	Imputed	C	DOMINANT	3.07E−05	3.07E−05	1.6289	1.6289	0.6561	0
  rs12418971	Imputed	C	GENOTYPIC	3.47E−05	3.47E−05	2.4809	2.4809	0.4834	0
  rs12418971	Imputed	C	RECESSIVE	6.71E−05	6.71E−05	2.3563	2.3563	0.5471	0
  rs1241967	Imputed	T	RECESSIVE	7.19E−05	7.19E−05	0.5103	0.5103	0.3812	0
  rs12420184	Imputed	G	DOMINANT	9.08E−03	4.26E−01	0.7449	0.7927	0.0017	84.33
  rs12433968	Imputed	T	DOMINANT	7.59E−04	1.18E−01	0.707	0.741	0.0375	69.54
  rs12445477	Imputed	A	DOMINANT	6.41E−05	8.38E−05	0.5585	0.5583	0.357	2.92
  rs12447191	Genotyped	T	ADDITIVE	8.95E−05	8.95E−05	0.6925	0.6925	0.818	0
  rs12447191	Genotyped	T	DOMINANT	5.17E−05	5.17E−05	0.6473	0.6473	0.3993	0
  rs12465349	Imputed	A	RECESSIVE	3.69E−05	3.69E−05	1.6009	1.6009	0.6932	0
  rs1247340	Imputed	C	ADDITIVE	7.69E−03	3.65E−01	1.2697	1.2218	0.0029	82.86
  rs1247340	Imputed	C	DOMINANT	0.0003633	0.0921	1.4554	1.406	0.0314	71.11
  rs1247341	Imputed	C	ADDITIVE	0.006355	0.3353	1.2777	1.2307	0.004	81.86
  rs1247341	Imputed	C	DOMINANT	3.13E−04	0.07821	1.4625	1.4174	0.0367	69.74
  rs1247343	Imputed	C	DOMINANT	3.36E−04	7.38E−03	1.4916	1.47	0.2058	36.74
  rs12509758	Imputed	C	DOMINANT	6.36E−05	6.36E−05	1.5131	1.5131	0.4849	0
  rs12515472	Imputed	A	DOMINANT	9.90E−05	9.90E−05	1.5106	1.5106	0.3966	0
  rs12548906	Imputed	G	ADDITIVE	4.27E−05	4.27E−05	1.4718	1.4718	0.4259	0
  rs12596240	Imputed	G	DOMINANT	1.60E−04	0.003727	0.6751	0.6862	0.2247	33.03
  rs12618781	Imputed	A	DOMINANT	1.01E−03	0.07896	0.6934	0.7084	0.0532	65.92
  rs12678600	Imputed	A	DOMINANT	5.24E−05	5.24E−05	0.665	0.665	0.5424	0
  rs12692229	Imputed	T	ADDITIVE	6.42E−05	6.42E−05	1.3491	1.3491	0.3777	0
  rs12713324	Imputed	T	DOMINANT	6.12E−05	6.12E−05	1.5047	1.5047	0.9505	0
  rs12719415	Imputed	T	DOMINANT	2.31E−05	2.31E−05	0.6505	0.6505	0.8585	0
  rs12820589	Imputed	G	ADDITIVE	1.70E−03	1.48E−01	1.3433	1.3243	0.0167	75.57
  rs12820589	Imputed	G	DOMINANT	1.50E−03	9.38E−02	1.4056	1.3931	0.0399	68.95
  rs12831292	Imputed	G	ADDITIVE	2.24E−05	2.24E−05	0.7299	0.7299	0.8379	0
  rs12831292	Imputed	G	DOMINANT	1.03E−05	1.03E−05	0.6291	0.6291	0.7999	0
  rs13012636	Imputed	G	RECESSIVE	7.97E−05	7.97E−05	1.996	1.996	0.5232	0
  rs13038146	Imputed	C	ADDITIVE	1.20E−05	1.20E−05	1.3766	1.3766	0.9732	0
  rs13038146	Imputed	C	GENOTYPIC	7.24E−06	7.24E−06	2.0174	2.0174	0.8918	0
  rs13038146	Imputed	C	RECESSIVE	6.47E−05	6.47E−05	1.7879	1.7879	0.5965	0
  rs13089860	Imputed	A	DOMINANT	8.44E−05	8.44E−05	0.6273	0.6273	0.9636	0
  rs13102419	Imputed	T	RECESSIVE	2.95E−04	0.003722	1.5536	1.5326	0.2434	29.22
  rs13194907	Imputed	A	ADDITIVE	4.90E−04	0.01486	1.6504	1.6306	0.1555	46.27
  rs13194907	Imputed	A	DOMINANT	0.0002179	0.004282	1.7592	1.7417	0.2106	35.82
  rs13195745	Imputed	A	ADDITIVE	5.08E−04	1.48E−02	1.6483	1.629	0.1573	45.94
  rs13195745	Imputed	A	DOMINANT	2.27E−04	4.24E−03	1.7567	1.7397	0.2126	35.41
  rs13265054	Imputed	T	DOMINANT	5.66E−05	5.66E−05	0.6647	0.6647	0.7133	0
  rs13273002	Imputed	A	GENOTYPIC	4.84E−04	1.49E−02	0.3723	0.3925	0.1872	40.32
  rs13282131	Imputed	C	ADDITIVE	3.71E−05	3.71E−05	1.3435	1.3435	0.8944	0
  rs13282131	Imputed	C	GENOTYPIC	1.60E−05	1.60E−05	1.8634	1.8634	0.9531	0
  rs13282131	Imputed	C	RECESSIVE	3.52E−05	3.52E−05	1.6677	1.6677	0.8497	0
  rs1330052	Imputed	G	GENOTYPIC	4.52E−03	2.69E−01	1.5788	1.4648	0.0124	77.22
  rs1335721	Imputed	A	RECESSIVE	3.43E−04	1.13E−02	0.6128	0.6267	0.1732	42.96
  rs1336382	Imputed	T	DOMINANT	3.16E−05	3.16E−05	1.5202	1.5202	0.7133	0
  rs1336383	Imputed	T	DOMINANT	2.98E−05	2.98E−05	1.5214	1.5214	0.7093	0
  rs1336407	Imputed	T	DOMINANT	4.97E−05	4.97E−05	1.5023	1.5023	0.7397	0
  rs1336409	Imputed	T	DOMINANT	4.97E−05	4.97E−05	1.5023	1.5023	0.7397	0
  rs1336596	Imputed	A	DOMINANT	0.0001018	0.03965	0.6696	0.6977	0.0654	63.33
  rs13387284	Imputed	A	DOMINANT	8.75E−04	0.08529	0.688	0.7034	0.044	67.99
  rs13401462	Imputed	C	DOMINANT	3.10E−04	1.15E−01	1.5296	1.4898	0.0127	77.09
  rs13409045	Imputed	T	ADDITIVE	1.07E−03	4.28E−02	0.786	0.7926	0.0962	57.29
  rs1349284	Imputed	C	GENOTYPIC	0.00058	0.0204	1.7388	1.6882	0.1518	46.96
  rs1355715	Imputed	T	ADDITIVE	9.33E−05	9.33E−05	0.5378	0.5378	0.685	0
  rs1357696	Imputed	A	GENOTYPIC	0.0009292	0.05615	1.6955	1.6136	0.0952	57.47
  rs1357698	Imputed	A	GENOTYPIC	8.00E−04	4.78E−02	1.7026	1.6275	0.1002	56.54
  rs1357699	Imputed	T	GENOTYPIC	0.0008002	0.04784	1.7026	1.6275	0.1002	56.54
  rs1363273	Imputed	C	RECESSIVE	5.45E−04	1.84E−02	0.6477	0.6596	0.1541	46.53
  rs1373601	Imputed	A	DOMINANT	2.77E−04	0.01048	0.6816	0.6853	0.1561	46.15
  rs1375829	Imputed	C	GENOTYPIC	5.80E−04	0.0204	1.7388	1.6882	0.1518	46.96
  rs1395748	Imputed	G	DOMINANT	4.33E−03	2.60E−01	0.7518	0.7852	0.0125	77.17
  rs1414865	Imputed	T	DOMINANT	5.22E−05	5.22E−05	1.503	1.503	0.7135	0
  rs1414873	Imputed	A	DOMINANT	4.97E−05	4.97E−05	1.5023	1.5023	0.7397	0
  rs1414876	Imputed	C	DOMINANT	4.97E−05	4.97E−05	1.5023	1.5023	0.7397	0
  rs1424643	Imputed	G	ADDITIVE	3.10E−05	3.10E−05	1.4271	1.4271	0.7865	0
  rs1424643	Imputed	G	DOMINANT	1.30E−05	1.30E−05	1.5651	1.5651	0.8673	0
  rs1424648	Imputed	T	DOMINANT	9.94E−05	9.94E−05	1.486	1.486	0.6958	0
  rs1429321	Imputed	A	DOMINANT	7.77E−05	7.77E−05	1.4953	1.4953	0.9675	0
  rs1429326	Imputed	T	ADDITIVE	9.21E−05	9.21E−05	1.399	1.399	0.8323	0
  rs1429326	Imputed	T	DOMINANT	3.60E−05	3.60E−05	1.5277	1.5277	0.9565	0
  rs1444741	Imputed	A	DOMINANT	2.75E−04	2.69E−02	0.6829	0.6887	0.0868	59.09
  rs1449916	Imputed	C	DOMINANT	1.95E−05	1.95E−05	0.5625	0.5625	0.3711	0
  rs1459523	Imputed	A	ADDITIVE	3.66E−04	4.28E−03	1.3013	1.2939	0.2362	30.7
  rs1459523	Imputed	A	GENOTYPIC	4.70E−04	0.02682	1.7552	1.6884	0.1274	51.46
  rs1466352	Imputed	T	GENOTYPIC	0.0005775	0.02214	1.7187	1.6652	0.1488	47.51
  rs1466353	Imputed	G	GENOTYPIC	0.0005742	0.02215	1.7191	1.6655	0.1486	47.55
  rs1476714	Imputed	A	DOMINANT	2.39E−05	2.39E−05	0.6504	0.6504	0.8559	0
  rs1486723	Imputed	C	RECESSIVE	6.53E−05	6.53E−05	0.5173	0.5173	0.6824	0
  rs1495375	Imputed	A	ADDITIVE	4.26E−05	4.26E−05	0.7384	0.7384	0.8941	0
  rs1495375	Imputed	A	DOMINANT	2.29E−05	2.29E−05	0.6402	0.6402	0.8341	0
  rs1495381	Imputed	T	GENOTYPIC	6.50E−05	6.50E−05	1.8347	1.8347	0.5926	0
  rs1495381	Imputed	T	RECESSIVE	1.60E−05	1.60E−05	1.8065	1.8065	0.8326	0
  rs1498061	Imputed	C	ADDITIVE	3.02E−05	3.02E−05	0.5576	0.5576	0.7263	0
  rs1498992	Imputed	G	DOMINANT	3.76E−05	3.76E−05	0.6602	0.6602	0.6375	0
  rs1499001	Imputed	T	DOMINANT	2.63E−05	2.63E−05	0.6507	0.6507	0.4397	0
  rs1512988	Imputed	A	ADDITIVE	2.04E−05	2.04E−05	0.7286	0.7286	0.7895	0
  rs1512988	Imputed	A	DOMINANT	1.46E−05	1.46E−05	0.6349	0.6349	0.7791	0
  rs1512989	Imputed	T	ADDITIVE	2.04E−05	2.04E−05	0.7286	0.7286	0.7895	0
  rs1512989	Imputed	T	DOMINANT	1.46E−05	1.46E−05	0.6349	0.6349	0.7791	0
  rs1512991	Imputed	T	ADDITIVE	1.75E−05	1.75E−05	0.7317	0.7317	0.9424	0
  rs1512991	Imputed	T	DOMINANT	2.76E−05	2.76E−05	0.6327	0.6327	0.8654	0
  rs1512991	Imputed	T	GENOTYPIC	5.58E−05	5.58E−05	0.5525	0.5525	0.7914	0
  rs1524303	Imputed	T	GENOTYPIC	0.0005851	0.02098	1.7312	1.675	0.1554	46.29
  rs1524306	Imputed	C	ADDITIVE	0.000344	0.004662	1.3028	1.295	0.2276	32.44
  rs1524306	Imputed	C	GENOTYPIC	4.48E−04	2.71E−02	1.7589	1.6915	0.1248	51.94
  rs1524310	Imputed	G	ADDITIVE	2.72E−04	2.93E−03	1.3102	1.3039	0.2464	28.62
  rs1524310	Imputed	G	GENOTYPIC	0.0003497	0.01684	1.7827	1.724	0.1509	47.13
  rs1524321	Imputed	C	GENOTYPIC	3.30E−04	8.74E−03	1.772	1.7335	0.1931	39.2
  rs1527059	Imputed	A	DOMINANT	6.83E−05	6.83E−05	0.577	0.577	0.3905	0
  rs152707	Imputed	A	ADDITIVE	0.001601	0.1313	0.7957	0.8167	0.0376	69.53
  rs152707	Imputed	A	GENOTYPIC	1.86E−03	1.35E−01	0.6257	0.6605	0.0389	69.2
  rs152712	Genotyped	C	ADDITIVE	0.001213	0.1285	0.7908	0.812	0.0331	70.67
  rs152712	Genotyped	C	GENOTYPIC	0.001349	0.1341	0.6169	0.6528	0.0328	70.74
  rs1533994	Imputed	T	GENOTYPIC	0.0004988	0.02256	1.7311	1.674	0.142	48.77
  rs1535866	Imputed	G	DOMINANT	9.86E−05	9.86E−05	1.4938	1.4938	0.5229	0
  rs1563773	Imputed	T	GENOTYPIC	0.0006151	0.02321	1.7166	1.6611	0.1482	47.61
  rs1563774	Imputed	T	GENOTYPIC	0.0006165	0.02322	1.7172	1.6635	0.1469	47.87
  rs1567740	Imputed	T	ADDITIVE	1.99E−05	1.99E−05	0.7287	0.7287	0.7926	0
  rs1567740	Imputed	T	DOMINANT	1.35E−05	1.35E−05	0.634	0.634	0.765	0
  rs1572573	Imputed	A	DOMINANT	0.0004861	0.03203	1.4535	1.4085	0.1213	52.6
  rs1577497	Imputed	C	RECESSIVE	0.000359	0.01133	0.6139	0.6277	0.1749	42.64
  rs1581514	Imputed	T	ADDITIVE	0.0003311	0.003803	1.3057	1.2997	0.2373	30.49
  rs1581514	Imputed	T	GENOTYPIC	0.0004261	0.02325	1.7652	1.7041	0.1328	50.48
  rs1582321	Imputed	T	DOMINANT	0.0001513	0.003601	0.6742	0.6852	0.2244	33.07
  rs1582322	Imputed	A	DOMINANT	0.0001591	0.0008772	0.674	0.6797	0.3001	16.91
  rs1582323	Imputed	A	DOMINANT	0.0001659	0.001455	0.6747	0.6823	0.2779	21.9
  rs1592485	Imputed	C	DOMINANT	0.000161	0.001019	0.6729	0.6792	0.294	18.31
  rs1600954	Imputed	T	ADDITIVE	4.63E−05	4.63E−05	1.3445	1.3445	0.5721	0
  rs1600954	Imputed	T	GENOTYPIC	4.57E−05	4.57E−05	1.8147	1.8147	0.542	0
  rs16938626	Imputed	G	DOMINANT	3.76E−05	3.76E−05	0.659	0.659	0.6465	0
  rs16964300	Imputed	G	ADDITIVE	6.56E−05	6.56E−05	0.6892	0.6892	0.8019	0
  rs16964300	Imputed	G	DOMINANT	3.18E−05	3.18E−05	0.6401	0.6401	0.4292	0
  rs16986282	Imputed	G	DOMINANT	4.72E−05	4.72E−05	0.4011	0.4011	0.3857	0
  rs17007620	Imputed	G	ADDITIVE	0.00042	0.01992	1.3669	1.3587	0.1192	52.98
  rs17007620	Imputed	G	DOMINANT	0.0001365	0.003601	1.5086	1.5037	0.1945	38.93
  rs17014326	Imputed	G	DOMINANT	0.00215	0.2476	0.7351	0.7739	0.0097	78.44
  rs17047957	Imputed	C	DOMINANT	3.23E−05	3.23E−05	1.5756	1.5756	0.7413	0
  rs1705261	Imputed	A	RECESSIVE	2.52E−05	2.52E−05	1.7737	1.7737	0.834	0
  rs17073341	Imputed	A	ADDITIVE	9.48E−05	9.48E−05	2.0844	2.0844	0.3839	0
  rs17073341	Imputed	A	DOMINANT	7.90E−05	7.90E−05	2.1417	2.1417	0.3765	0
  rs17138702	Imputed	G	ADDITIVE	0.004	0.216	0.7417	0.7591	0.0117	77.5
  rs17189710	Imputed	T	ADDITIVE	1.26E−05	1.26E−05	1.3776	1.3776	0.9806	0
  rs17189710	Imputed	T	GENOTYPIC	7.08E−06	7.08E−06	2.0265	2.0265	0.8812	0
  rs17189710	Imputed	T	RECESSIVE	5.89E−05	5.89E−05	1.7991	1.7991	0.569	0
  rs17310176	Imputed	T	ADDITIVE	6.02E−05	6.02E−05	0.6787	0.6787	0.5641	0
  rs17310176	Imputed	T	DOMINANT	4.51E−05	4.51E−05	0.6409	0.6409	0.4149	0
  rs17358860	Imputed	A	DOMINANT	5.45E−05	5.45E−05	0.6457	0.6457	0.4986	0
  rs17370541	Imputed	T	GENOTYPIC	0.0003366	0.01452	1.7812	1.7046	0.176	42.44
  rs17370541	Imputed	T	RECESSIVE	0.0002644	0.004097	1.7173	1.6801	0.2409	29.74
  rs17526574	Imputed	G	GENOTYPIC	0.002555	0.1386	1.6824	1.6185	0.0319	70.98
  rs17530747	Imputed	T	DOMINANT	0.0007294	0.06795	0.7034	0.7357	0.0872	59.01
  rs17649114	Imputed	C	DOMINANT	5.86E−05	5.86E−05	1.5179	1.5179	0.5026	0
  rs17766172	Imputed	A	RECESSIVE	4.67E−05	4.67E−05	0.4975	0.4975	0.483	0
  rs1818885	Imputed	G	GENOTYPIC	0.0004892	0.02726	1.756	1.6897	0.1265	51.64
  rs1832222	Imputed	G	DOMINANT	5.68E−05	5.68E−05	1.4978	1.4978	0.7483	0
  rs1861327	Imputed	G	DOMINANT	0.0001308	0.002055	0.67	0.6796	0.2521	27.42
  rs1868581	Imputed	G	ADDITIVE	0.0003858	0.009401	1.3009	1.2907	0.1844	40.85
  rs1868581	Imputed	G	GENOTYPIC	0.0004728	0.03115	1.7583	1.6889	0.1157	53.63
  rs1874313	Imputed	A	ADDITIVE	3.53E−05	3.53E−05	0.7362	0.7362	0.736	0
  rs1874313	Imputed	A	DOMINANT	2.05E−05	2.05E−05	0.6403	0.6403	0.7327	0
  rs1876409	Imputed	C	DOMINANT	0.003381	0.227	0.746	0.7766	0.0157	75.94
  rs1913201	Imputed	G	ADDITIVE	2.15E−05	2.15E−05	0.7321	0.7321	0.9128	0
  rs1913201	Imputed	G	DOMINANT	6.73E−05	6.73E−05	0.6474	0.6474	0.8659	0
  rs1913201	Imputed	G	GENOTYPIC	6.26E−05	6.26E−05	0.5503	0.5503	0.7315	0
  rs1916922	Imputed	T	GENOTYPIC	0.0006243	0.02368	1.7596	1.7018	0.1488	47.52
  rs1936871	Genotyped	G	DOMINANT	8.55E−05	8.55E−05	0.6616	0.6616	0.3925	0
  rs1961157	Imputed	T	RECESSIVE	0.002404	0.1282	0.68	0.6899	0.0283	71.94
  rs1987179	Imputed	T	ADDITIVE	9.76E−05	9.76E−05	0.6985	0.6985	0.7616	0
  rs1987179	Imputed	T	DOMINANT	6.37E−06	6.37E−06	0.6204	0.6204	0.6462	0
  rs1990023	Imputed	T	DOMINANT	1.72E−05	1.72E−05	0.6468	0.6468	0.8317	0
  rs1995025	Imputed	C	DOMINANT	7.87E−05	7.87E−05	1.5633	1.5633	0.7042	0
  rs2016194	Imputed	G	DOMINANT	2.38E−05	2.38E−05	0.651	0.651	0.8576	0
  rs2023651	Imputed	T	ADDITIVE	0.002541	0.2484	0.7624	0.7886	0.0082	79.2
  rs2024902	Imputed	A	ADDITIVE	0.0005049	0.01577	1.6486	1.6285	0.152	46.92
  rs2024902	Imputed	A	DOMINANT	0.0002252	0.004699	1.7569	1.739	0.2058	36.74
  rs2025107	Imputed	A	DOMINANT	0.0008183	0.05061	1.6029	1.5881	0.0749	61.42
  rs2025108	Imputed	T	DOMINANT	0.001038	0.04754	1.5831	1.5581	0.0932	57.86
  rs2031987	Imputed	T	GENOTYPIC	0.002645	0.1394	1.6843	1.6228	0.0311	71.19
  rs2052428	Imputed	C	DOMINANT	6.07E−05	6.07E−05	0.6359	0.6359	0.7925	0
  rs2053230	Imputed	C	ADDITIVE	0.0001481	0.003644	0.6297	0.6429	0.2766	22.2
  rs2062448	Imputed	T	DOMINANT	0.0003871	0.004058	0.6188	0.6264	0.2457	28.76
  rs2063420	Imputed	C	RECESSIVE	0.001837	0.1146	1.4963	1.443	0.0468	67.35
  rs2063591	Imputed	C	ADDITIVE	7.27E−05	7.27E−05	0.7518	0.7518	0.9305	0
  rs2063591	Imputed	C	DOMINANT	4.26E−05	4.26E−05	0.6381	0.6381	0.8973	0
  rs208026	Genotyped	A	DOMINANT	6.33E−05	6.33E−05	1.4986	1.4986	0.9606	0
  rs208029	Imputed	T	DOMINANT	3.75E−05	3.75E−05	1.5349	1.5349	0.4541	0
  rs208757	Imputed	G	DOMINANT	3.01E−05	3.01E−05	1.5343	1.5343	0.5566	0
  rs2095586	Imputed	A	DOMINANT	3.68E−05	3.68E−05	1.5163	1.5163	0.6839	0
  rs2095606	Imputed	A	DOMINANT	5.61E−05	0.01913	0.6593	0.6816	0.0926	57.97
  rs2102374	Imputed	A	ADDITIVE	0.001363	0.2021	0.7686	0.7983	0.0117	77.54
  rs2102374	Imputed	A	DOMINANT	0.001202	0.1846	0.7215	0.7489	0.0116	77.55
  rs2108426	Imputed	C	DOMINANT	2.38E−05	2.38E−05	0.651	0.651	0.8576	0
  rs2110664	Imputed	A	DOMINANT	3.76E−05	3.76E−05	1.532	1.532	0.6276	0
  rs2132242	Imputed	A	ADDITIVE	1.93E−05	1.93E−05	0.7293	0.7293	0.8549	0
  rs2132242	Imputed	A	DOMINANT	1.23E−05	1.23E−05	0.6323	0.6323	0.8457	0
  rs2158958	Imputed	A	DOMINANT	2.31E−05	2.31E−05	0.6505	0.6505	0.8585	0
  rs2158961	Imputed	G	DOMINANT	4.37E−05	4.37E−05	0.663	0.663	0.936	0
  rs2163046	Imputed	A	DOMINANT	7.62E−05	7.62E−05	1.4981	1.4981	0.988	0
  rs2180286	Imputed	G	DOMINANT	6.63E−05	6.63E−05	0.6345	0.6345	0.8013	0
  rs2180684	Imputed	A	DOMINANT	2.68E−05	2.68E−05	1.7201	1.7201	0.9033	0
  rs2188079	Imputed	C	ADDITIVE	0.0004508	0.01972	1.2881	1.2834	0.1244	52.01
  rs2188079	Imputed	C	GENOTYPIC	0.0002443	0.007437	1.7178	1.7019	0.1776	42.15
  rs2190598	Imputed	T	DOMINANT	2.31E−05	2.31E−05	0.6505	0.6505	0.8585	0
  rs2190600	Imputed	A	DOMINANT	2.54E−05	2.54E−05	0.6504	0.6504	0.7871	0
  rs2224184	Genotyped	T	DOMINANT	8.75E−05	8.75E−05	0.6414	0.6414	0.8155	0
  rs2247066	Imputed	A	DOMINANT	0.004329	0.2604	0.7518	0.7852	0.0125	77.17
  rs2248236	Imputed	C	ADDITIVE	2.90E−05	2.90E−05	0.676	0.676	0.7802	0
  rs2248236	Imputed	C	DOMINANT	1.58E−06	1.58E−06	0.596	0.596	0.8313	0
  rs2265733	Imputed	C	ADDITIVE	0.001363	0.2021	0.7686	0.7983	0.0117	77.54
  rs2265733	Imputed	C	DOMINANT	0.001202	0.1846	0.7215	0.7489	0.0116	77.55
  rs2270584	Imputed	A	ADDITIVE	2.02E−05	2.02E−05	0.7312	0.7312	0.8826	0
  rs2270584	Imputed	A	DOMINANT	2.32E−06	2.32E−06	0.6123	0.6123	0.8509	0
  rs2270586	Imputed	A	ADDITIVE	2.39E−05	2.39E−05	0.7334	0.7334	0.8691	0
  rs2270586	Imputed	A	DOMINANT	3.16E−06	3.16E−06	0.6167	0.6167	0.8138	0
  rs229775	Imputed	A	RECESSIVE	7.19E−05	7.19E−05	0.5103	0.5103	0.3812	0
  rs229815	Imputed	T	RECESSIVE	9.48E−05	9.48E−05	0.5099	0.5099	0.5285	0
  rs229829	Imputed	C	RECESSIVE	9.98E−05	9.98E−05	0.5548	0.5548	0.8369	0
  rs229831	Imputed	A	RECESSIVE	8.91E−05	8.91E−05	0.5096	0.5096	0.3946	0
  rs2317057	Imputed	T	ADDITIVE	6.41E−05	6.41E−05	0.6839	0.6839	0.7046	0
  rs2322100	Genotyped	T	RECESSIVE	4.07E−05	4.07E−05	2.2062	2.2062	0.5484	0
  rs2322101	Imputed	A	RECESSIVE	3.66E−05	3.66E−05	2.218	2.218	0.5273	0
  rs2327929	Imputed	G	RECESSIVE	3.43E−05	3.43E−05	1.6873	1.6873	0.4473	0
  rs2332844	Imputed	A	ADDITIVE	3.09E−05	3.09E−05	1.6598	1.6598	0.5134	0
  rs2332844	Imputed	A	RECESSIVE	6.54E−05	6.54E−05	1.7248	1.7248	0.7183	0
  rs2349170	Imputed	G	DOMINANT	9.67E−05	9.67E−05	1.4926	1.4926	0.6711	0
  rs2356722	Imputed	G	DOMINANT	0.002651	0.2845	0.7401	0.7804	0.0062	80.31
  rs2364956	Imputed	T	ADDITIVE	0.000127	0.0002252	1.4305	1.4298	0.3433	6.47
  rs2373793	Imputed	G	ADDITIVE	4.62E−05	4.62E−05	1.4791	1.4791	0.7939	0
  rs2373793	Imputed	G	DOMINANT	2.34E−05	2.34E−05	1.5985	1.5985	0.6098	0
  rs238252	Imputed	G	ADDITIVE	8.76E−05	0.0001795	1.4845	1.4806	0.3424	6.69
  rs238252	Imputed	G	DOMINANT	6.01E−05	0.0004281	1.5806	1.5679	0.292	18.76
  rs2383903	Imputed	G	DOMINANT	4.71E−05	4.71E−05	0.6638	0.6638	0.7307	0
  rs2387945	Imputed	G	DOMINANT	7.60E−05	7.60E−05	1.5615	1.5615	0.6844	0
  rs2389863	Imputed	A	DOMINANT	1.22E−05	1.22E−05	0.6334	0.6334	0.7957	0
  rs2389866	Imputed	C	DOMINANT	4.66E−06	4.66E−06	0.6225	0.6225	0.7145	0
  rs2389869	Imputed	C	DOMINANT	4.66E−06	4.66E−06	0.6225	0.6225	0.7145	0
  rs2389870	Genotyped	C	DOMINANT	6.46E−05	6.46E−05	0.6493	0.6493	0.3855	0
  rs2418494	Imputed	G	ADDITIVE	9.79E−05	9.79E−05	0.7569	0.7569	0.5664	0
  rs2418494	Imputed	G	GENOTYPIC	9.28E−05	9.28E−05	0.5712	0.5712	0.5491	0
  rs2418541	Imputed	A	DOMINANT	1.72E−05	1.72E−05	0.6468	0.6468	0.8317	0
  rs2418542	Imputed	A	DOMINANT	1.88E−05	1.88E−05	0.6481	0.6481	0.8316	0
  rs2423556	Imputed	C	DOMINANT	7.99E−05	7.99E−05	0.635	0.635	0.8112	0
  rs2437688	Imputed	C	ADDITIVE	7.95E−05	7.95E−05	1.591	1.591	0.4782	0
  rs2456809	Imputed	G	DOMINANT	0.002716	0.1918	0.7406	0.7699	0.0226	73.61
  rs2456811	Imputed	T	ADDITIVE	0.001617	0.2162	0.7717	0.802	0.0106	77.99
  rs2456811	Imputed	T	DOMINANT	0.001438	0.1994	0.7251	0.7532	0.0104	78.1
  rs2476976	Imputed	C	DOMINANT	6.91E−05	6.91E−05	1.4908	1.4908	0.8073	0
  rs2484911	Imputed	A	DOMINANT	9.19E−05	9.19E−05	1.4801	1.4801	0.8339	0
  rs2488557	Imputed	C	DOMINANT	0.000454	0.009593	0.6571	0.6684	0.1949	38.85
  rs250162	Imputed	C	ADDITIVE	7.89E−06	7.89E−06	0.6754	0.6754	0.5537	0
  rs250162	Imputed	C	DOMINANT	3.91E−06	3.91E−06	0.6207	0.6207	0.4842	0
  rs2560708	Imputed	T	ADDITIVE	8.04E−05	8.04E−05	0.6746	0.6746	0.7071	0
  rs2617841	Imputed	G	DOMINANT	7.42E−05	7.42E−05	0.6584	0.6584	0.6003	0
  rs2622499	Imputed	G	DOMINANT	5.66E−06	5.66E−06	0.6251	0.6251	0.6966	0
  rs264129	Imputed	T	DOMINANT	4.75E−05	4.75E−05	0.6631	0.6631	0.9256	0
  rs2642936	Imputed	T	ADDITIVE	0.0008203	0.04658	1.3495	1.3354	0.0879	58.88
  rs2660633	Imputed	A	DOMINANT	0.003381	0.227	0.746	0.7766	0.0157	75.94
  rs2660634	Imputed	C	DOMINANT	0.003381	0.227	0.746	0.7766	0.0157	75.94
  rs2660648	Imputed	A	ADDITIVE	0.001363	0.2021	0.7686	0.7983	0.0117	77.54
  rs2660648	Imputed	A	DOMINANT	0.001202	0.1846	0.7215	0.7489	0.0116	77.55
  rs2681505	Imputed	T	ADDITIVE	2.69E−05	2.69E−05	0.6941	0.6941	0.3782	0
  rs277411	Imputed	G	DOMINANT	0.002587	0.1087	0.5246	0.4938	0.0195	74.6
  rs2832634	Imputed	G	ADDITIVE	9.75E−05	9.75E−05	1.8259	1.8259	0.7829	0
  rs2832637	Imputed	T	ADDITIVE	9.75E−05	9.75E−05	1.8259	1.8259	0.7829	0
  rs2843167	Imputed	A	DOMINANT	0.001237	0.1278	0.7224	0.7509	0.0362	69.86
  rs2876227	Imputed	C	ADDITIVE	2.82E−05	2.82E−05	1.362	1.362	0.97	0
  rs2876227	Imputed	C	GENOTYPIC	1.54E−05	1.54E−05	1.9854	1.9854	0.8563	0
  rs2882097	Imputed	A	DOMINANT	2.98E−05	2.98E−05	1.5214	1.5214	0.7093	0
  rs2909862	Imputed	G	DOMINANT	0.0004342	0.0219	1.5096	1.4698	0.1401	49.11
  rs3001945	Imputed	T	DOMINANT	7.34E−05	7.34E−05	1.5785	1.5785	0.8106	0
  rs3011020	Imputed	C	DOMINANT	7.27E−05	7.27E−05	1.5634	1.5634	0.6833	0
  rs36071725	Genotyped	C	ADDITIVE	0.0001148	0.05399	1.3419	1.3062	0.0432	68.17
  rs36071725	Genotyped	C	GENOTYPIC	0.0001469	0.1424	1.9245	1.7281	0.0116	77.56
  rs373983	Imputed	G	DOMINANT	2.26E−05	2.26E−05	1.5782	1.5782	0.441	0
  rs3743794	Imputed	G	DOMINANT	0.0002394	0.002286	0.6809	0.6895	0.2695	23.73
  rs3756154	Imputed	C	ADDITIVE	8.74E−05	8.74E−05	0.6973	0.6973	0.7453	0
  rs3756154	Imputed	C	DOMINANT	5.57E−06	5.57E−06	0.6194	0.6194	0.6345	0
  rs3775850	Imputed	A	DOMINANT	4.28E−05	4.28E−05	0.6406	0.6406	0.4572	0
  rs3775851	Imputed	C	DOMINANT	5.58E−05	5.58E−05	0.6449	0.6449	0.4625	0
  rs3793044	Imputed	C	ADDITIVE	0.0006211	0.01526	1.6363	1.6145	0.1659	44.33
  rs3793044	Imputed	C	DOMINANT	0.0002821	0.004123	1.7429	1.7248	0.2257	32.82
  rs3793053	Imputed	C	DOMINANT	0.0006344	0.04352	1.6268	1.6074	0.0815	60.12
  rs3796246	Imputed	G	DOMINANT	0.0006434	0.02777	0.6293	0.6362	0.1152	53.73
  rs3806003	Imputed	A	ADDITIVE	0.0006211	0.01526	1.6363	1.6145	0.1659	44.33
  rs3806003	Imputed	A	DOMINANT	0.0002821	0.004123	1.7429	1.7248	0.2257	32.82
  rs3806004	Imputed	T	DOMINANT	0.0008183	0.05061	1.6029	1.5881	0.0749	61.42
  rs3806010	Imputed	T	DOMINANT	0.0008183	0.05061	1.6029	1.5881	0.0749	61.42
  rs3806014	Imputed	T	DOMINANT	0.0006528	0.0397	1.6219	1.6045	0.0892	58.62
  rs3806015	Imputed	A	DOMINANT	0.0007014	0.04258	1.6162	1.5981	0.0866	59.13
  rs3806018	Imputed	A	DOMINANT	0.001012	0.05137	1.5918	1.5803	0.0785	60.71
  rs3806019	Imputed	A	DOMINANT	0.0009044	0.0577	1.5971	1.581	0.0678	62.83
  rs3806024	Imputed	T	DOMINANT	0.0006532	0.0428	1.619	1.6067	0.0793	60.54
  rs3915080	Imputed	A	GENOTYPIC	0.0006483	0.0458	1.7202	1.6467	0.095	57.52
  rs3942254	Imputed	T	ADDITIVE	2.13E−05	2.13E−05	0.7274	0.7274	0.9089	0
  rs3942254	Imputed	T	DOMINANT	9.53E−06	9.53E−06	0.6253	0.6253	0.9519	0
  rs3945085	Imputed	A	DOMINANT	3.27E−05	3.27E−05	1.519	1.519	0.687	0
  rs3976737	Imputed	G	ADDITIVE	0.003945	0.2806	0.7457	0.7798	0.0081	79.23
  rs399485	Imputed	A	DOMINANT	4.97E−05	4.97E−05	1.5032	1.5032	0.8617	0
  rs4029119	Imputed	G	ADDITIVE	0.004166	0.1177	0.5395	0.4424	0.0069	79.92
  rs4029119	Imputed	G	DOMINANT	0.008687	0.1677	0.5356	0.4664	0.0072	79.71
  rs4076201	Imputed	G	GENOTYPIC	5.99E−05	5.99E−05	2.6809	2.6809	0.7622	0
  rs4076201	Imputed	G	RECESSIVE	6.53E−05	6.53E−05	2.6253	2.6253	0.7419	0
  rs41395945	Imputed	G	ADDITIVE	7.48E−05	7.48E−05	1.8482	1.8482	0.7926	0
  rs41395945	Imputed	G	DOMINANT	8.37E−05	8.37E−05	1.9099	1.9099	0.8616	0
  rs4146972	Genotyped	T	DOMINANT	3.95E−05	3.95E−05	1.5614	1.5614	0.6547	0
  rs4238087	Imputed	G	DOMINANT	9.82E−05	9.82E−05	0.6268	0.6268	0.5018	0
  rs4251569	Imputed	T	ADDITIVE	9.93E−05	9.93E−05	0.6551	0.6551	0.6066	0
  rs4251569	Imputed	T	DOMINANT	8.05E−05	8.05E−05	0.6254	0.6254	0.4972	0
  rs4273613	Imputed	T	ADDITIVE	0.002876	0.1046	0.5269	0.4225	0.0055	80.81
  rs4273613	Imputed	T	DOMINANT	0.005931	0.1502	0.5204	0.4449	0.0058	80.6
  rs4291049	Imputed	T	RECESSIVE	0.002115	0.1545	0.6826	0.7124	0.0331	70.66
  rs4315598	Imputed	T	ADDITIVE	1.33E−05	1.33E−05	1.3742	1.3742	0.9673	0
  rs4315598	Imputed	T	GENOTYPIC	8.02E−06	8.02E−06	2.0108	2.0108	0.8929	0
  rs4315598	Imputed	T	RECESSIVE	6.81E−05	6.81E−05	1.7847	1.7847	0.5993	0
  rs4321395	Imputed	A	DOMINANT	0.0008748	0.08529	0.688	0.7034	0.044	67.99
  rs4321596	Genotyped	T	RECESSIVE	9.95E−05	9.95E−05	2.3838	2.3838	0.8271	0
  rs4324417	Imputed	T	DOMINANT	0.0004684	0.01009	1.4729	1.4477	0.1952	38.79
  rs4328619	Genotyped	G	DOMINANT	8.16E−05	8.16E−05	0.6393	0.6393	0.768	0
  rs4338909	Imputed	T	ADDITIVE	0.0009962	0.03681	1.2613	1.2511	0.1094	54.81
  rs4370878	Imputed	G	DOMINANT	5.08E−05	5.08E−05	1.5041	1.5041	0.6831	0
  rs4379434	Genotyped	T	DOMINANT	0.0008974	0.03349	1.4182	1.3922	0.1216	52.53
  rs4416407	Imputed	T	DOMINANT	7.89E−05	7.89E−05	1.6055	1.6055	0.6011	0
  rs4417899	Imputed	C	RECESSIVE	7.35E−05	7.35E−05	0.6217	0.6217	0.5918	0
  rs4442732	Imputed	A	ADDITIVE	0.0002973	0.01275	0.7154	0.7312	0.1721	43.17
  rs4444612	Imputed	G	ADDITIVE	1.05E−05	1.05E−05	1.38	1.38	0.9803	0
  rs4444612	Imputed	G	GENOTYPIC	6.88E−06	6.88E−06	2.022	2.022	0.8907	0
  rs4444612	Imputed	G	RECESSIVE	6.51E−05	6.51E−05	1.7874	1.7874	0.5969	0
  rs4450660	Imputed	C	DOMINANT	6.12E−05	6.12E−05	1.5007	1.5007	0.4999	0
  rs4509702	Imputed	C	DOMINANT	5.08E−05	5.08E−05	1.5041	1.5041	0.6831	0
  rs4526920	Imputed	G	GENOTYPIC	0.002645	0.1394	1.6843	1.6228	0.0311	71.19
  rs4533145	Imputed	T	DOMINANT	0.06008	0.6325	0.7887	0.8292	0.0001	89.37
  rs4557006	Imputed	A	DOMINANT	0.001528	0.089	0.6986	0.7133	0.0548	65.56
  rs4570530	Imputed	C	DOMINANT	5.08E−05	5.08E−05	1.5041	1.5041	0.6831	0
  rs4615971	Imputed	C	DOMINANT	4.82E−05	4.82E−05	1.5038	1.5038	0.7548	0
  rs4628119	Imputed	A	DOMINANT	0.0009573	0.07481	0.7135	0.7203	0.0461	67.51
  rs4664443	Imputed	G	ADDITIVE	0.0009373	0.04269	0.7841	0.7912	0.0927	57.96
  rs4688259	Imputed	T	DOMINANT	7.88E−05	7.88E−05	1.6056	1.6056	0.5986	0
  rs4688632	Imputed	G	RECESSIVE	4.49E−05	4.49E−05	0.6188	0.6188	0.7162	0
  rs4695284	Imputed	A	ADDITIVE	6.68E−05	6.68E−05	1.8181	1.8181	0.5549	0
  rs4700302	Imputed	A	ADDITIVE	0.002913	0.1394	0.6642	0.6808	0.0345	70.31
  rs4702720	Imputed	A	ADDITIVE	4.29E−05	4.29E−05	0.6727	0.6727	0.6127	0
  rs4702720	Imputed	A	DOMINANT	2.14E−05	2.14E−05	0.6116	0.6116	0.5842	0
  rs4711091	Genotyped	G	GENOTYPIC	0.003111	0.235	1.5203	1.4091	0.02	74.42
  rs4714484	Imputed	A	ADDITIVE	6.43E−05	0.0001399	0.6741	0.6745	0.3377	7.89
  rs4736802	Imputed	G	DOMINANT	0.0007866	0.03886	1.4239	1.3953	0.1046	55.7
  rs4760785	Imputed	A	ADDITIVE	2.15E−05	2.15E−05	0.7321	0.7321	0.9128	0
  rs4760785	Imputed	A	DOMINANT	6.73E−05	6.73E−05	0.6474	0.6474	0.8659	0
  rs4760785	Imputed	A	GENOTYPIC	6.26E−05	6.26E−05	0.5503	0.5503	0.7315	0
  rs4760894	Imputed	T	ADDITIVE	2.15E−05	2.15E−05	0.7321	0.7321	0.9128	0
  rs4760894	Imputed	T	DOMINANT	6.73E−05	6.73E−05	0.6474	0.6474	0.8659	0
  rs4760894	Imputed	T	GENOTYPIC	6.26E−05	6.26E−05	0.5503	0.5503	0.7315	0
  rs4760895	Imputed	A	ADDITIVE	2.15E−05	2.15E−05	0.7321	0.7321	0.9128	0
  rs4760895	Imputed	A	DOMINANT	6.73E−05	6.73E−05	0.6474	0.6474	0.8659	0
  rs4760895	Imputed	A	GENOTYPIC	6.26E−05	6.26E−05	0.5503	0.5503	0.7315	0
  rs4764738	Imputed	A	ADDITIVE	0.0009266	0.07954	1.2709	1.2594	0.0439	68.01
  rs4764738	Imputed	A	GENOTYPIC	0.001005	0.08625	1.6088	1.5782	0.0404	68.83
  rs4764974	Imputed	T	ADDITIVE	0.003078	0.1633	1.2361	1.2211	0.0224	73.69
  rs4764974	Imputed	T	GENOTYPIC	0.003002	0.1626	1.5291	1.4908	0.0225	73.63
  rs4798366	Imputed	G	RECESSIVE	4.20E−05	4.20E−05	2.0082	2.0082	0.3989	0
  rs483159	Imputed	T	DOMINANT	7.40E−05	7.40E−05	1.5348	1.5348	0.4489	0
  rs4836502	Imputed	T	DOMINANT	2.31E−05	2.31E−05	0.6505	0.6505	0.8585	0
  rs4836507	Imputed	C	DOMINANT	2.65E−05	2.65E−05	0.6512	0.6512	0.7993	0
  rs4836744	Imputed	A	ADDITIVE	5.65E−05	5.65E−05	0.7302	0.7302	0.9215	0
  rs4836744	Imputed	A	DOMINANT	9.27E−05	9.27E−05	0.6763	0.6763	0.9561	0
  rs4848944	Genotyped	C	RECESSIVE	9.83E−05	9.83E−05	0.6206	0.6206	0.3871	0
  rs4851529	Imputed	A	DOMINANT	2.19E−05	2.19E−05	0.6441	0.6441	0.7104	0
  rs4851531	Imputed	T	DOMINANT	3.21E−05	3.21E−05	0.6474	0.6474	0.5448	0
  rs4858046	Genotyped	T	GENOTYPIC	0.0006163	0.0233	1.7237	1.6703	0.1446	48.29
  rs4878214	Imputed	A	ADDITIVE	3.88E−05	3.88E−05	0.6738	0.6738	0.5061	0
  rs4880803	Imputed	A	ADDITIVE	9.69E−05	9.69E−05	0.7391	0.7391	0.6783	0
  rs489441	Imputed	G	ADDITIVE	2.53E−05	2.53E−05	1.4225	1.4225	0.5025	0
  rs489441	Imputed	G	DOMINANT	2.68E−05	2.68E−05	1.5463	1.5463	0.8089	0
  rs4896568	Imputed	T	DOMINANT	0.001111	0.06921	0.7129	0.7224	0.06	64.45
  rs4938851	Imputed	T	DOMINANT	3.87E−05	3.87E−05	1.5301	1.5301	0.5447	0
  rs4964416	Imputed	C	DOMINANT	9.70E−05	9.70E−05	0.6422	0.6422	0.8344	0
  rs5756669	Imputed	C	DOMINANT	0.0004684	0.01009	1.4729	1.4477	0.1952	38.79
  rs6033138	Imputed	C	ADDITIVE	7.29E−06	7.29E−06	1.3851	1.3851	0.9889	0
  rs6033138	Imputed	C	GENOTYPIC	6.04E−06	6.04E−06	2.0122	2.0122	0.8928	0
  rs6033138	Imputed	C	RECESSIVE	7.08E−05	7.08E−05	1.7649	1.7649	0.6157	0
  rs6040619	Imputed	C	ADDITIVE	4.47E−06	4.47E−06	1.3986	1.3986	0.8222	0
  rs6040619	Imputed	C	GENOTYPIC	2.25E−06	2.25E−06	2.1003	2.1003	0.9241	0
  rs6040619	Imputed	C	RECESSIVE	2.09E−05	2.09E−05	1.861	1.861	0.8676	0
  rs6040625	Imputed	T	ADDITIVE	5.19E−06	5.19E−06	1.395	3 1.3953	0.8592	0
  rs6040625	Imputed	T	GENOTYPIC	3.08E−06	3.08E−06	2.0812	2.0812	0.9469	0
  rs6040625	Imputed	T	RECESSIVE	3.05E−05	3.05E−05	1.8401	1.8401	0.8473	0
  rs6040630	Imputed	A	ADDITIVE	9.20E−06	9.20E−06	1.383	1.383	0.9581	0
  rs6040630	Imputed	A	GENOTYPIC	5.55E−06	5.55E−06	2.0375	2.0375	0.9148	0
  rs6040630	Imputed	A	RECESSIVE	5.12E−05	5.12E−05	1.8039	1.8039	0.6621	0
  rs6040633	Imputed	A	ADDITIVE	1.25E−05	1.25E−05	1.3756	1.3756	0.969	0
  rs6040633	Imputed	A	GENOTYPIC	7.70E−06	7.70E−06	2.0134	2.0134	0.8921	0
  rs6040633	Imputed	A	RECESSIVE	6.75E−05	6.75E−05	1.7849	1.7849	0.6011	0
  rs6040634	Imputed	T	ADDITIVE	1.00E−05	1.00E−05	1.3804	1.3804	0.9666	0
  rs6040634	Imputed	T	GENOTYPIC	6.55E−06	6.55E−06	2.0241	2.0241	0.8798	0
  rs6040634	Imputed	T	RECESSIVE	6.47E−05	6.47E−05	1.7879	1.7879	0.5965	0
  rs6040636	Imputed	T	ADDITIVE	1.31E−05	1.31E−05	1.3748	1.3748	0.9806	0
  rs6040636	Imputed	T	GENOTYPIC	7.73E−06	7.73E−06	2.0134	2.0134	0.9037	0
  rs6040636	Imputed	T	RECESSIVE	6.47E−05	6.47E−05	1.7879	1.7879	0.5965	0
  rs6040638	Imputed	C	ADDITIVE	1.20E−05	1.20E−05	1.3766	1.3766	0.9732	0
  rs6040638	Imputed	C	GENOTYPIC	7.24E−06	7.24E−06	2.0174	2.0174	0.8918	0
  rs6040638	Imputed	C	RECESSIVE	6.47E−05	6.47E−05	1.7879	1.7879	0.5965	0
  rs6040644	Imputed	A	ADDITIVE	1.20E−05	1.20E−05	1.3766	1.3766	0.9732	0
  rs6040644	Imputed	A	GENOTYPIC	7.24E−06	7.24E−06	2.0174	2.0174	0.8918	0
  rs6040644	Imputed	A	RECESSIVE	6.47E−05	6.47E−05	1.7879	1.7879	0.5965	0
  rs6040667	Imputed	T	ADDITIVE	1.20E−05	1.20E−05	1.3804	1.3804	0.9597	0
  rs6040667	Imputed	T	GENOTYPIC	7.88E−06	7.88E−06	2.0249	2.0249	0.8444	0
  rs6040667	Imputed	T	RECESSIVE	7.44E−05	7.44E−05	1.7892	1.7892	0.5844	0
  rs6040668	Imputed	C	ADDITIVE	1.73E−05	1.73E−05	1.373	1.373	0.98	0
  rs6040668	Imputed	C	GENOTYPIC	1.05E−05	1.05E−05	2.0115	2.0115	0.8502	0
  rs6040668	Imputed	C	RECESSIVE	9.40E−05	9.40E−05	1.7793	1.7793	0.5751	0
  rs6043066	Genotyped	G	DOMINANT	9.84E−05	9.84E−05	1.4879	1.4879	0.4214	0
  rs6048146	Imputed	G	DOMINANT	5.02E−05	5.02E−05	2.6243	2.6243	0.8749	0
  rs6082725	Genotyped	T	DOMINANT	5.02E−05	5.02E−05	2.6243	2.6243	0.8749	0
  rs6131206	Imputed	C	ADDITIVE	7.67E−05	7.67E−05	1.3544	1.3544	0.6023	0
  rs6131208	Imputed	T	ADDITIVE	1.43E−05	1.43E−05	1.3763	1.3763	0.9848	0
  rs6131208	Imputed	T	GENOTYPIC	8.33E−06	8.33E−06	2.0252	2.0252	0.879	0
  rs6131208	Imputed	T	RECESSIVE	7.25E−05	7.25E−05	1.7953	1.7953	0.6033	0
  rs6134243	Imputed	C	ADDITIVE	1.20E−05	1.20E−05	1.3766	1.3766	0.9732	0
  rs6134243	Imputed	C	GENOTYPIC	7.24E−06	7.24E−06	2.0174	2.0174	0.8918	0
  rs6134243	Imputed	C	RECESSIVE	6.47E−05	6.47E−05	1.7879	1.7879	0.5965	0
  rs6136020	Imputed	A	DOMINANT	0.001161	0.126	0.6966	0.7316	0.042	68.46
  rs613799	Imputed	C	DOMINANT	7.75E−05	7.75E−05	1.5158	1.5158	0.7849	0
  rs644041	Imputed	G	ADDITIVE	8.78E−05	8.78E−05	1.391	1.391	0.5335	0
  rs644041	Imputed	G	DOMINANT	7.42E−05	7.42E−05	1.5143	1.5143	0.8073	0
  rs647645	Imputed	C	ADDITIVE	6.86E−05	0.001002	0.7509	0.7567	0.2638	24.95
  rs647645	Imputed	C	GENOTYPIC	9.70E−05	0.006546	0.5657	0.581	0.1711	43.36
  rs647645	Imputed	C	RECESSIVE	0.001082	0.1079	0.6612	0.6805	0.034	70.43
  rs6495554	Imputed	C	GENOTYPIC	4.76E−05	4.76E−05	2.9048	2.9048	0.6375	0
  rs6495554	Imputed	C	RECESSIVE	7.67E−05	7.67E−05	2.7833	2.7833	0.6295	0
  rs6495555	Imputed	C	GENOTYPIC	4.76E−05	4.76E−05	2.9048	2.9048	0.6375	0
  rs6495555	Imputed	C	RECESSIVE	7.67E−05	7.67E−05	2.7833	2.7833	0.6295	0
  rs6544728	Imputed	T	DOMINANT	1.47E−05	1.47E−05	1.5526	1.5526	0.4629	0
  rs6550705	Imputed	C	ADDITIVE	0.00038	0.004853	1.3004	1.2925	0.2297	32.02
  rs6550705	Imputed	C	GENOTYPIC	0.0004703	0.0268	1.7552	1.6884	0.1275	51.46
  rs6550707	Imputed	T	GENOTYPIC	0.0005925	0.02351	1.7169	1.6622	0.1452	48.18
  rs658108	Imputed	A	DOMINANT	9.19E−05	9.19E−05	1.4801	1.4801	0.8339	0
  rs6593441	Imputed	A	DOMINANT	8.32E−05	8.32E−05	1.5966	1.5966	0.6727	0
  rs668732	Imputed	A	DOMINANT	0.0007713	0.04322	1.4673	1.4272	0.1016	56.26
  rs671041	Imputed	A	DOMINANT	7.41E−05	7.41E−05	1.4878	1.4878	0.8316	0
  rs6719700	Imputed	A	ADDITIVE	9.48E−05	9.48E−05	1.4547	1.4547	0.8457	0
  rs6719700	Imputed	A	DOMINANT	9.05E−05	9.05E−05	1.5345	1.5345	0.997	0
  rs6722640	Imputed	T	DOMINANT	6.69E−06	6.69E−06	0.6251	0.6251	0.6987	0
  rs6743092	Imputed	T	ADDITIVE	8.16E−05	8.16E−05	1.3286	1.3286	0.8471	0
  rs6743092	Imputed	T	GENOTYPIC	7.98E−05	7.98E−05	1.7638	1.7638	0.836	0
  rs6743092	Imputed	T	RECESSIVE	2.27E−05	2.27E−05	1.6478	1.6478	0.7669	0
  rs6744759	Imputed	G	RECESSIVE	8.79E−05	8.79E−05	1.9877	1.9877	0.536	0
  rs6746170	Imputed	A	DOMINANT	2.07E−05	2.07E−05	1.5394	1.5394	0.5817	0
  rs6759922	Imputed	A	DOMINANT	0.001026	0.0855	0.6912	0.7071	0.0483	66.99
  rs6769864	Imputed	T	GENOTYPIC	0.0004564	0.02145	1.7578	1.6967	0.1428	48.63
  rs6773932	Imputed	C	GENOTYPIC	0.000867	0.04735	1.6964	1.6233	0.1035	55.91
  rs6774353	Imputed	A	GENOTYPIC	0.0005033	0.02669	1.7503	1.6851	0.1298	51.02
  rs6781670	Imputed	C	GENOTYPIC	0.00058	0.0204	1.7388	1.6882	0.1518	46.96
  rs6786431	Imputed	A	GENOTYPIC	0.000867	0.04735	1.6964	1.6233	0.1035	55.91
  rs6789091	Imputed	T	GENOTYPIC	0.000867	0.04735	1.6964	1.6233	0.1035	55.91
  rs6791296	Imputed	T	ADDITIVE	7.12E−05	7.12E−05	0.6329	0.6329	0.9898	0
  rs6792662	Imputed	G	DOMINANT	6.98E−05	6.98E−05	1.6112	1.6112	0.5862	0
  rs6797574	Imputed	G	GENOTYPIC	0.000867	0.04735	1.6964	1.6233	0.1035	55.91
  rs6797882	Imputed	G	GENOTYPIC	0.0008269	0.04785	1.7009	1.6266	0.1009	56.4
  rs6805139	Imputed	G	DOMINANT	3.85E−05	3.85E−05	1.6152	1.6152	0.6499	0
  rs6806043	Imputed	C	ADDITIVE	0.0003052	0.005086	1.306	1.2979	0.2161	34.72
  rs6806043	Imputed	C	GENOTYPIC	0.0004109	0.02711	1.7655	1.6976	0.1213	52.6
  rs6850716	Imputed	C	GENOTYPIC	0.003416	0.1872	2.0499	1.9631	0.0177	75.23
  rs6867153	Imputed	A	RECESSIVE	0.00187	0.191	0.678	0.7117	0.0177	75.21
  rs687047	Imputed	C	ADDITIVE	9.00E−05	9.00E−05	0.6446	0.6446	0.7637	0
  rs6871041	Imputed	G	DOMINANT	2.29E−05	2.29E−05	0.6393	0.6393	0.8477	0
  rs688358	Imputed	A	ADDITIVE	7.44E−05	7.44E−05	0.6401	0.6401	0.8637	0
  rs6888012	Imputed	A	RECESSIVE	0.001885	0.1924	0.6781	0.7121	0.0175	75.29
  rs6908481	Imputed	C	RECESSIVE	5.99E−05	5.99E−05	1.7201	1.7201	0.5809	0
  rs7032231	Imputed	A	ADDITIVE	6.99E−05	6.99E−05	1.352	1.352	0.3922	0
  rs7067638	Imputed	T	DOMINANT	8.99E−05	8.99E−05	1.5963	1.5963	0.7456	0
  rs7077799	Imputed	A	DOMINANT	7.58E−05	7.58E−05	1.4996	1.4996	0.7406	0
  rs7082163	Imputed	A	ADDITIVE	5.34E−05	5.34E−05	1.5444	1.5444	0.4266	0
  rs7082163	Imputed	A	DOMINANT	3.46E−05	3.46E−05	1.641	1.641	0.6461	0
  rs7089661	Imputed	C	DOMINANT	4.97E−05	4.97E−05	1.5023	1.5023	0.7397	0
  rs7101319	Imputed	C	ADDITIVE	5.28E−05	5.28E−05	1.5457	1.5457	0.468	0
  rs7101319	Imputed	C	DOMINANT	3.22E−05	3.22E−05	1.6456	1.6456	0.7067	0
  rs710832	Genotyped	A	GENOTYPIC	6.03E−05	6.03E−05	0.3754	0.3754	0.8143	0
  rs710832	Genotyped	A	RECESSIVE	3.36E−05	3.36E−05	0.3689	0.3689	0.7382	0
  rs7134262	Imputed	T	GENOTYPIC	2.96E−05	2.96E−05	1.9763	1.9763	0.627	0
  rs7134262	Imputed	T	RECESSIVE	1.46E−06	1.46E−06	2.0802	2.0802	0.5227	0
  rs7134671	Imputed	T	GENOTYPIC	0.0002855	0.005252	1.7315	1.725	0.1999	37.89
  rs7138300	Imputed	C	ADDITIVE	2.15E−05	2.15E−05	0.7321	0.7321	0.9128	0
  rs7138300	Imputed	C	DOMINANT	6.73E−05	6.73E−05	0.6474	0.6474	0.8659	0
  rs7138300	Imputed	C	GENOTYPIC	6.26E−05	6.26E−05	0.5503	0.5503	0.7315	0
  rs7163931	Imputed	G	GENOTYPIC	4.76E−05	4.76E−05	2.9048	2.9048	0.6375	0
  rs7163931	Imputed	G	RECESSIVE	7.67E−05	7.67E−05	2.7833	2.7833	0.6295	0
  rs7171486	Genotyped	G	DOMINANT	7.21E−05	7.21E−05	0.6684	0.6684	0.4022	0
  rs7172611	Imputed	G	GENOTYPIC	4.65E−05	4.65E−05	2.9093	2.9093	0.6341	0
  rs7172611	Imputed	G	RECESSIVE	7.67E−05	7.67E−05	2.7833	2.7833	0.6295	0
  rs7172689	Imputed	T	GENOTYPIC	4.65E−05	4.65E−05	2.9093	2.9093	0.6341	0
  rs7172689	Imputed	T	RECESSIVE	7.67E−05	7.67E−05	2.7833	2.7833	0.6295	0
  rs7175701	Imputed	C	GENOTYPIC	9.05E−05	9.05E−05	2.5914	2.5914	0.7706	0
  rs7180245	Imputed	A	GENOTYPIC	4.65E−05	4.65E−05	2.9093	2.9093	0.6341	0
  rs7180245	Imputed	A	RECESSIVE	7.67E−05	7.67E−05	2.7833	2.7833	0.6295	0
  rs7220603	Genotyped	A	ADDITIVE	0.02391	0.5255	0.8346	0.8604	0.0003	87.88
  rs7282518	Imputed	T	ADDITIVE	0.0002567	0.008981	1.453	1.4275	0.1773	42.19
  rs7283476	Imputed	T	ADDITIVE	7.31E−05	7.31E−05	0.4402	0.4402	0.566	0
  rs7283476	Imputed	T	DOMINANT	3.52E−05	3.52E−05	0.4064	0.4064	0.4235	0
  rs7295817	Imputed	C	GENOTYPIC	7.67E−05	7.67E−05	0.5483	0.5483	0.4481	0
  rs7298255	Imputed	A	ADDITIVE	3.91E−05	3.91E−05	0.7439	0.7439	0.9855	0
  rs7298255	Imputed	A	DOMINANT	6.89E−05	6.89E−05	0.65	0.65	0.7442	0
  rs7305832	Imputed	C	GENOTYPIC	2.48E−05	2.48E−05	1.9853	1.9853	0.5975	0
  rs7305832	Imputed	C	RECESSIVE	1.31E−06	1.31E−06	2.0856	2.0856	0.5058	0
  rs7331467	Imputed	A	GENOTYPIC	0.004523	0.2685	1.5788	1.4648	0.0124	77.22
  rs7392620	Imputed	C	ADDITIVE	8.20E−05	8.20E−05	0.7361	0.7361	0.6441	0
  rs742827	Imputed	A	ADDITIVE	8.46E−06	8.46E−06	1.3961	1.3961	0.9898	0
  rs742827	Imputed	A	GENOTYPIC	7.47E−06	7.47E−06	2.0465	2.0465	0.8196	0
  rs742827	Imputed	A	RECESSIVE	9.50E−05	9.50E−05	1.7817	1.7817	0.5729	0
  rs7446891	Imputed	G	DOMINANT	2.31E−05	2.31E−05	0.6505	0.6505	0.8585	0
  rs7448641	Imputed	C	ADDITIVE	0.002876	0.1046	0.5269	0.4225	0.0055	80.81
  rs7448641	Imputed	C	DOMINANT	0.005931	0.1502	0.5204	0.4449	0.0058	80.6
  rs7484728	Imputed	T	GENOTYPIC	0.000266	0.005086	1.736	1.7289	0.1995	37.97
  rs7499402	Genotyped	A	ADDITIVE	7.41E−05	7.41E−05	1.7018	1.7018	0.5603	0
  rs7529851	Imputed	A	ADDITIVE	7.64E−05	7.64E−05	0.7438	0.7438	0.6011	0
  rs7529851	Imputed	A	GENOTYPIC	8.65E−05	8.65E−05	0.5413	0.5413	0.7417	0
  rs7573951	Imputed	G	ADDITIVE	0.0009373	0.04269	0.7841	0.7912	0.0927	57.96
  rs7599198	Imputed	T	DOMINANT	0.0005956	0.01854	0.6706	0.6818	0.1584	45.74
  rs7600050	Imputed	C	ADDITIVE	6.57E−05	6.57E−05	1.3535	1.3535	0.6858	0
  rs7607712	Imputed	T	ADDITIVE	6.22E−05	6.22E−05	1.4258	1.4258	0.846	0
  rs7607712	Imputed	T	DOMINANT	8.77E−05	8.77E−05	1.4994	1.4994	0.9843	0
  rs7613492	Imputed	G	GENOTYPIC	0.0004892	0.02726	1.756	1.6897	0.1265	51.64
  rs7621663	Imputed	G	ADDITIVE	0.0002694	0.00593	1.3166	1.3062	0.1995	37.97
  rs7621663	Imputed	G	GENOTYPIC	0.0002328	0.03627	1.849	1.7635	0.0774	60.91
  rs7621663	Imputed	G	RECESSIVE	0.001212	0.0888	1.6632	1.577	0.0599	64.48
  rs7626584	Imputed	G	ADDITIVE	9.18E−05	9.18E−05	0.5375	0.5375	0.6785	0
  rs7684899	Imputed	C	ADDITIVE	9.76E−05	9.76E−05	0.6985	0.6985	0.7616	0
  rs7684899	Imputed	C	DOMINANT	6.37E−06	6.37E−06	0.6204	0.6204	0.6462	0
  rs7701604	Imputed	G	ADDITIVE	0.002876	0.1046	0.5269	0.4225	0.0055	80.81
  rs7701604	Imputed	G	DOMINANT	0.005931	0.1502	0.5204	0.4449	0.0058	80.6
  rs7703676	Imputed	C	ADDITIVE	0.002876	0.1046	0.5269	0.4225	0.0055	80.81
  rs7703676	Imputed	C	DOMINANT	0.005931	0.1502	0.5204	0.4449	0.0058	80.6
  rs7708491	Imputed	C	RECESSIVE	0.002355	0.1727	0.6852	0.7155	0.0267	72.41
  rs7711358	Imputed	A	DOMINANT	1.88E−05	1.88E−05	0.6481	0.6481	0.8316	0
  rs7719448	Imputed	G	RECESSIVE	0.002108	0.2193	0.6815	0.7163	0.012	77.4
  rs7724761	Imputed	T	RECESSIVE	0.001686	0.19	0.6737	0.7045	0.0154	76.06
  rs7742476	Imputed	T	DOMINANT	0.0001163	0.0001163	1.5074	1.5074	0.3696	0
  rs7762993	Imputed	A	ADDITIVE	0.0003347	0.004615	1.3933	1.3716	0.2531	27.21
  rs7762993	Imputed	A	DOMINANT	9.42E−05	0.01287	1.507	1.4653	0.1301	50.97
  rs7767265	Imputed	G	ADDITIVE	1.59E−05	0.000172	1.4422	1.4296	0.296	17.87
  rs7767265	Imputed	G	DOMINANT	6.30E−06	0.003597	1.5886	1.5475	0.1294	51.09
  rs7768128	Imputed	G	RECESSIVE	9.37E−05	9.37E−05	0.3867	0.3867	0.8076	0
  rs7771264	Imputed	T	DOMINANT	0.00106	0.07475	0.7141	0.7193	0.046	67.53
  rs7773151	Genotyped	C	DOMINANT	0.000959	0.06482	0.7135	0.7189	0.055	65.52
  rs7773210	Genotyped	A	DOMINANT	0.0008239	0.06306	0.7105	0.7165	0.0539	65.76
  rs7808536	Imputed	G	DOMINANT	8.84E−05	8.84E−05	1.5126	1.5126	0.3832	0
  rs7843510	Genotyped	G	DOMINANT	0.0008947	0.03339	1.418	1.392	0.1219	52.48
  rs7894867	Imputed	T	DOMINANT	7.78E−05	7.78E−05	1.6032	1.6032	0.7494	0
  rs7921834	Imputed	C	DOMINANT	5.41E−05	5.41E−05	1.4996	1.4996	0.7497	0
  rs7939893	Imputed	C	ADDITIVE	8.65E−05	8.65E−05	0.7474	0.7474	0.6566	0
  rs7939893	Imputed	C	DOMINANT	9.08E−06	9.08E−06	0.6395	0.6395	0.3716	0
  rs7944513	Imputed	T	GENOTYPIC	1.13E−05	1.13E−05	2.6894	2.6894	0.5228	0
  rs7944513	Imputed	T	RECESSIVE	3.32E−05	3.32E−05	2.5007	2.5007	0.3973	0
  rs7949720	Imputed	G	ADDITIVE	0.01083	0.46	0.7505	0.8044	0.0015	84.54
  rs7949720	Imputed	G	DOMINANT	0.009467	0.4625	0.7247	0.7836	0.0012	85.09
  rs7955901	Imputed	C	ADDITIVE	3.31E−05	3.31E−05	0.7403	0.7403	0.9802	0
  rs7955901	Imputed	C	DOMINANT	6.34E−05	6.34E−05	0.6473	0.6473	0.8105	0
  rs7956274	Imputed	T	ADDITIVE	2.32E−05	2.32E−05	0.7349	0.7349	0.9325	0
  rs7956274	Imputed	T	DOMINANT	3.52E−05	3.52E−05	0.6366	0.6366	0.8605	0
  rs7956274	Imputed	T	GENOTYPIC	7.30E−05	7.30E−05	0.5575	0.5575	0.7749	0
  rs7957932	Imputed	G	ADDITIVE	5.54E−05	5.54E−05	0.7481	0.7481	0.9512	0
  rs7957932	Imputed	G	DOMINANT	3.06E−05	3.06E−05	0.6329	0.6329	0.8798	0
  rs7984504	Imputed	C	GENOTYPIC	0.002726	0.1381	1.6689	1.6043	0.0349	70.18
  rs7999518	Imputed	A	RECESSIVE	2.72E−05	2.72E−05	0.5848	0.5848	0.4425	0
  rs8026245	Imputed	G	GENOTYPIC	7.79E−05	7.79E−05	2.665	2.665	0.6771	0
  rs8026245	Imputed	G	RECESSIVE	8.54E−05	8.54E−05	2.6107	2.6107	0.6577	0
  rs8060725	Genotyped	A	ADDITIVE	9.99E−05	9.99E−05	0.7239	0.7239	0.8435	0
  rs8103016	Genotyped	A	ADDITIVE	1.98E−05	1.98E−05	1.4503	1.4503	0.4547	0
  rs8103016	Genotyped	A	DOMINANT	2.45E−05	2.45E−05	1.5482	1.5482	0.694	0
  rs8104182	Imputed	G	ADDITIVE	3.24E−05	3.24E−05	1.4421	1.4421	0.671	0
  rs8104182	Imputed	G	DOMINANT	4.77E−05	4.77E−05	1.5265	1.5265	0.7687	0
  rs8129461	Imputed	G	ADDITIVE	3.70E−05	3.70E−05	0.4263	0.4263	0.5257	0
  rs8129461	Imputed	G	DOMINANT	1.72E−05	1.72E−05	0.3933	0.3933	0.3761	0
  rs8130021	Imputed	G	ADDITIVE	7.55E−05	7.55E−05	0.4409	0.4409	0.5674	0
  rs8130021	Imputed	G	DOMINANT	3.64E−05	3.64E−05	0.4071	0.4071	0.4256	0
  rs879961	Imputed	T	ADDITIVE	0.002059	0.2563	0.7763	0.8081	0.0066	80.11
  rs879961	Imputed	T	DOMINANT	0.001811	0.2398	0.7301	0.7595	0.0059	80.5
  rs906353	Imputed	A	DOMINANT	0.004624	0.2465	0.7527	0.7852	0.0165	75.63
  rs915491	Imputed	C	DOMINANT	8.48E−05	8.48E−05	1.4838	1.4838	0.752	0
  rs915493	Imputed	T	DOMINANT	8.48E−05	8.48E−05	1.4838	1.4838	0.752	0
  rs915494	Imputed	A	ADDITIVE	7.86E−05	7.86E−05	1.3658	1.3658	0.8997	0
  rs915494	Imputed	A	DOMINANT	2.62E−05	2.62E−05	1.5383	1.5383	0.8223	0
  rs917295	Imputed	G	DOMINANT	1.82E−05	1.82E−05	0.647	0.647	0.881	0
  rs9284851	Imputed	A	GENOTYPIC	0.0007416	0.04371	1.7018	1.6321	0.1049	55.65
  rs9293464	Imputed	T	RECESSIVE	0.00171	0.194	0.6758	0.7101	0.0158	75.88
  rs9295154	Genotyped	G	DOMINANT	7.58E−05	7.58E−05	1.5572	1.5572	0.5416	0
  rs9310221	Imputed	A	DOMINANT	0.001363	0.158	1.4328	1.353	0.0322	70.9
  rs9310699	Genotyped	T	GENOTYPIC	0.00058	0.0204	1.7388	1.6882	0.1518	46.96
  rs9310700	Imputed	C	ADDITIVE	0.0003931	0.005395	1.3049	1.2966	0.2216	33.63
  rs9310700	Imputed	C	GENOTYPIC	0.0003693	0.03198	1.8013	1.7265	0.1006	56.46
  rs9310701	Imputed	G	GENOTYPIC	0.0005775	0.02214	1.7187	1.6652	0.1488	47.51
  rs9310704	Imputed	G	GENOTYPIC	0.000597	0.04612	1.7265	1.6511	0.0921	58.07
  rs9319185	Imputed	C	GENOTYPIC	0.003084	0.2063	1.6765	1.5851	0.0147	76.3
  rs9319186	Imputed	T	GENOTYPIC	0.002645	0.1394	1.6843	1.6228	0.0311	71.19
  rs9327555	Imputed	T	DOMINANT	2.31E−05	2.31E−05	0.6505	0.6505	0.8585	0
  rs9403367	Imputed	C	DOMINANT	0.0008239	0.06306	0.7105	0.7165	0.0539	65.76
  rs9419608	Imputed	G	RECESSIVE	0.007479	0.5441	1.3778	1.2224	0.0008	85.89
  rs9426437	Imputed	T	DOMINANT	0.0007324	0.08646	0.6967	0.7283	0.0587	64.74
  rs9454967	Imputed	G	DOMINANT	0.0008641	0.05434	1.5996	1.5843	0.071	62.2
  rs9635511	Imputed	T	DOMINANT	0.0001778	0.001844	0.6752	0.6837	0.2682	24.02
  rs966583	Imputed	A	ADDITIVE	1.48E−05	1.48E−05	0.725	0.725	0.8807	0
  rs966583	Imputed	A	DOMINANT	7.60E−06	7.60E−06	0.626	0.626	0.8999	0
  rs980263	Imputed	T	GENOTYPIC	0.000492	0.02264	1.7325	1.6751	0.1412	48.92
  rs980264	Imputed	T	GENOTYPIC	0.000492	0.02264	1.7325	1.6751	0.1412	48.92
  rs9812206	Imputed	G	ADDITIVE	9.92E−05	0.03775	0.6049	0.6297	0.0642	63.57
  rs9812206	Imputed	G	DOMINANT	0.0001008	0.04527	0.592	0.6174	0.049	66.85
  rs9813552	Imputed	G	ADDITIVE	0.0004552	0.03885	0.6393	0.	0.0966	57.21
  rs9813552	Imputed	G	DOMINANT	0.0005252	0.05892	0.629	0.6531	0.0685	62.71
  rs9815037	Imputed	T	ADDITIVE	0.0003061	0.04794	0.6241	0.6399	0.0613	64.17
  rs9815037	Imputed	T	DOMINANT	0.0002862	0.06392	0.6094	0.6301	0.0425	68.34
  rs9819583	Imputed	T	GENOTYPIC	0.0005347	0.02047	1.7449	1.6926	0.1487	47.53
  rs9825349	Imputed	A	ADDITIVE	0.0003046	0.04763	0.624	0.6401	0.062	64.03
  rs9825349	Imputed	A	DOMINANT	0.0002859	0.0639	0.6094	0.6304	0.0427	68.28
  rs9833118	Imputed	G	ADDITIVE	0.0004117	0.006196	1.3	1.293	0.2139	35.15
  rs9833118	Imputed	G	GENOTYPIC	0.0004555	0.02726	1.7602	1.6961	0.123	52.28
  rs9834217	Imputed	T	ADDITIVE	0.0002698	0.03497	0.6218	0.6356	0.0789	60.62
  rs9834217	Imputed	T	DOMINANT	0.0002509	0.0487	0.607	0.6256	0.0556	65.39
  rs9838563	Imputed	C	GENOTYPIC	0.0004051	0.008482	1.7473	1.7073	0.2054	36.83
  rs9840460	Imputed	T	ADDITIVE	0.0002575	0.03523	0.6208	0.6345	0.0768	61.03
  rs9840460	Imputed	T	DOMINANT	0.0002389	0.04871	0.6059	0.6244	0.0543	65.67
  rs9840756	Imputed	A	ADDITIVE	0.0002251	0.02861	0.618	0.6307	0.0873	58.99
  rs9840756	Imputed	A	DOMINANT	0.0002087	0.04085	0.603	0.6206	0.0622	63.99
  rs9847999	Imputed	C	GENOTYPIC	0.0009186	0.04314	1.6854	1.6208	0.1128	54.17
  rs9864769	Imputed	C	GENOTYPIC	0.0005775	0.02214	1.7187	1.6652	0.1488	47.51
  rs9866421	Genotyped	C	RECESSIVE	8.99E−05	8.99E−05	0.5978	0.5978	0.7628	0
  rs987296	Imputed	T	GENOTYPIC	0.0006125	0.02328	1.7346	1.6817	0.1438	48.43
  rs9881685	Imputed	A	ADDITIVE	9.85E−05	0.03734	0.6048	0.6295	0.0647	63.48
  rs9881685	Imputed	A	DOMINANT	0.0001	0.04485	0.5918	0.6172	0.0494	66.76
  rs992695	Imputed	C	ADDITIVE	0.002041	0.2367	0.7764	0.8067	0.0089	78.81
  rs992695	Imputed	C	DOMINANT	0.001822	0.2163	0.7308	0.7583	0.009	78.78
  rs9936999	Imputed	G	DOMINANT	0.004771	0.2439	1.4561	1.3895	0.0142	76.48

• TABLE 19
  	allele				CARE	WOSCOPS

  A1

  allele

  Pla-

  Pla-

  (non-

  A2

  OR.

  Prava

  cebo

  OR

  OR

  P

  Prava

  cebo

  OR

  OR

  P

  End-

  Mod-

  SNP

  ref)

  (ref)

  P.R.

  R.

  Count

  count

  OR

  L95

  U95

  value

  Count

  Count

  OR

  L95

  U95

  value

  point

  el

  rs11556924

  A

  G

  0.00196

  1.33

  42/

  43/

  1.26

  1.01

  1.58

  0.0449

  28/

  22/

  1.48

  1.09

  2.02

  0.0123

  CHD

  add

  141/

  157/

  79/

  104/

  117

  182

  52

  98

• TABLE 20
  														GEN-	EV-
  														O_	ENTS_
  					GEN-		EV-	TO-					P_	PLA-	PLA-
  			mAF		O_	STA-	ENTS	TAL_	HR_	L95_	U95_	P_	INT_	CE-	CE-
  SNP hCV #	SNP rs #	Chrom	CEU	MODE	RESP	TIN	RESP	RESP	RESP	RESP	RESP	RESP	RESP	BO	BO
  hCV11841860	rs10757278	9p21	0.5	GEN	GG	Prava-	24	410	1.08	0.602	1.94	0.7931	0.1691	GG	21
  						statin
  hCV11841860	rs10757278	9p21	0.5	GEN	GG	Pla-	21	390	ref	.	.	.	0.1691		.
  						cebo
  hCV11841860	rs10757278	9p21	0.5	GEN	GA	Prava-	27	653	0.54	0.34	0.86	0.0096	0.1691	GA	52
  						statin
  hCV11841860	rs10757278	9p21	0.5	GEN	GA	Pla-	52	689	ref	.	.	.	0.1691		.
  						cebo
  hCV11841860	rs10757278	9p21	0.5	GEN	AA	Prava-	15	334	0.9	0.438	1.84	0.7666	0.1691	AA	15
  						statin
  hCV11841860	rs10757278	9p21	0.5	GEN	AA	Pla-	15	289	ref	.	.	.	0.1691		.
  						cebo
  hCV11841860	rs10757278	9p21	0.5	DOM	GA +	Prava-	51	1063	0.7	0.491	1.01	0.0533	0.6037	GA +	73
  					GG	statin								GG
  hCV11841860	rs10757278	9p21	0.5	DOM	GA +	Pla-	73	1079	ref	.	.	.	0.6037		.
  					GG	cebo
  hCV11841860	rs10757278	9p21	0.5	REC	GA +	Prava-	42	987	0.62	0.42	0.91	0.0146	0.118	GG	21
  					AA	statin
  hCV11841860	rs10757278	9p21	0.5	REC	GA +	Pla-	67	978	ref	.	.	.	0.118		.
  					AA	cebo
  hCV1754666	rs1333049	9p21	0.492	GEN	GG	Prava-	16	335	0.96	0.474	1.94	0.9086	0.1288	GG	15
  						statin
  hCV1754666	rs1333049	9p21	0.492	GEN	GG	Pla-	15	291	ref	.	.	.	0.1288		.
  						cebo
  hCV1754666	rs1333049	9p21	0.492	GEN	GC	Prava-	27	659	0.54	0.336	0.85	0.0085	0.1288	GC	52
  						statin
  hCV1754666	rs1333049	9p21	0.492	GEN	GC	Pla-	52	689	ref	.	.	.	0.1288		.
  						cebo
  hCV1754666	rs1333049	9p21	0.492	GEN	CC	Prava-	24	405	1.11	0.616	1.99	0.7346	0.1288	CC	21
  						statin
  hCV1754666	rs1333049	9p21	0.492	GEN	CC	Pla-	21	393	ref	.	.	.	0.1288		.
  						cebo
  hCV1754666	rs1333049	9p21	0.492	DOM	GC +	Prava-	43	994	0.63	0.429	0.92	0.018	0.1139	GC +	67
  					GG	statin								GG
  hCV1754666	rs1333049	9p21	0.492	DOM	GC +	Pla-	67	980	ref	.	.	.	0.1139		.
  					GG	cebo
  hCV1754666	rs1333049	9p21	0.492	REC	GC +	Prava-	51	1064	0.7	0.493	1.01	0.0549	0.4877	GG	15
  					CC	statin
  hCV1754666	rs1333049	9p21	0.492	REC	GC +	Pla-	73	1082	ref	.	.	.	0.4877		.
  					CC	cebo
  hCV12094896	rs12425791	12p13	0.175	GEN	AA	Prava-	2	60	0.28	0.058	1.35	0.1119	0.1255	AA	7
  						statin
  hCV12094896	rs12425791	12p13	0.175	GEN	AA	Pla-	7	60	ref	.	.	.	0.1255		.
  						cebo
  hCV12094896	rs12425791	12p13	0.175	GEN	AG	Prava-	22	485	0.56	0.331	0.96	0.0353	0.1255	AG	35
  						statin
  hCV12094896	rs12425791	12p13	0.175	GEN	AG	Pla-	35	442	ref	.	.	.	0.1255		.
  						cebo
  hCV12094896	rs12425791	12p13	0.175	GEN	GG	Prava-	43	852	0.95	0.628	1.44	0.8138	0.1255	GG	46
  						statin
  hCV12094896	rs12425791	12p13	0.175	GEN	GG	Pla-	46	867	ref	.	.	.	0.1255		.
  						cebo
  hCV12094896	rs12425791	12p13	0.175	DOM	AG +	Prava-	24	545	0.52	0.314	0.86	0.0101	0.0653	AG +	42
  					AA	statin								AA
  hCV12094896	rs12425791	12p13	0.175	DOM	AG +	Pla-	42	502	ref	.	.	.	0.0653		.
  					AA	cebo
  hCV12094896	rs12425791	12p13	0.175	REC	AG +	Prava-	65	1337	0.78	0.565	1.09	0.1411	0.1736	AA	7
  					GG	statin
  hCV12094896	rs12425791	12p13	0.175	REC	AG +	Pla-	81	1309	ref	.	.	.	0.1736		.
  					GG	cebo
  hCV1665834	rs11833579	12p13	0.225	GEN	AA	Prava-	3	99	0.26	0.072	0.95	0.0417	0.1885	AA	10
  						statin
  hCV1665834	rs11833579	12p13	0.225	GEN	AA	Pla-	10	91	ref	.	.	.	0.1885		.
  						cebo
  hCV1665834	rs11833579	12p13	0.225	GEN	AG	Prava-	29	566	0.75	0.46	1.22	0.2425	0.1885	AG	37
  						statin
  hCV1665834	rs11833579	12p13	0.225	GEN	AG	Pla-	37	541	ref	.	.	.	0.1885		.
  						cebo
  hCV1665834	rs11833579	12p13	0.225	GEN	GG	Prava-	35	730	0.86	0.55	1.36	0.5258	0.1885	GG	41
  						statin
  hCV1665834	rs11833579	12p13	0.225	GEN	GG	Pla-	41	739	ref	.	.	.	0.1885		.
  						cebo
  hCV1665834	rs11833579	12p13	0.225	DOM	AG +	Prava-	32	665	0.64	0.409	1	0.0523	0.3522	AG +	47
  					AA	statin								AA
  hCV1665834	rs11833579	12p13	0.225	DOM	AG +	Pla-	47	632	ref	.	.	.	0.3522		.
  					AA	cebo
  hCV1665834	rs11833579	12p13	0.225	REC	AG +	Prava-	64	1296	0.81	0.581	1.13	0.2091	0.0756	AA	10
  					GG	statin
  hCV1665834	rs11833579	12p13	0.225	REC	AG +	Pla-	78	1280	ref	.	.	.	0.0756		.
  					GG	cebo

  						P_
  	TO-	HR_	L95_	U95_	P_	DF2_
  	TAL_	PLA-	PLA-	PLA-	PLA-	PLA-	GEN-	EV-	TO-					P_
  	PLA-	CE-	CE-	CE-	CE-	CE-	O_	ENTS	TAL_	HR_	L95_	U95_	P_	DF2_
  SNP hCV #	CEBO	BO	BO	BO	BO	BO	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL
  hCV11841860	390	1.06	0.545	2.052	0.8676	0.2663	GG	45	800	1.18	0.744	1.876	0.479	0.639
  hCV11841860	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV11841860	689	1.47	0.826	2.607	0.1905	0.2663	GA	79	1342	1.22	0.803	1.862	0.3478	0.639
  hCV11841860	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV11841860	289	ref	.	.	.	0.2663	AA	30	623	ref	.	.	.	0.639
  hCV11841860	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV11841860	1079	1.32	0.758	2.302	0.3269	.	GA +	124	2142	1.21	0.81	1.8	0.3537	.
  							GG
  hCV11841860	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV11841860	390	0.8	0.488	1.3	0.3624	.	GG	45	800	1.03	0.725	1.451	0.8868	.
  hCV11841860	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1754666	291	0.95	0.488	1.836	0.8702	0.2539	GG	31	626	0.87	0.549	1.371	0.5427	0.727
  hCV1754666	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1754666	689	1.4	0.842	2.319	0.1961	0.2539	GC	79	1348	1.03	0.711	1.478	0.8939	0.727
  hCV1754666	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1754666	393	ref	.	.	.	0.2539	CC	45	798	ref	.	.	.	0.727
  hCV1754666	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1754666	980	1.26	0.773	2.061	0.3517	.	GC +	110	1974	0.98	0.689	1.379	0.8869	.
  							GG
  hCV1754666	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1754666	291	0.75	0.433	1.316	0.3212	.	GG	31	626	0.85	0.576	1.266	0.4317	.
  hCV1754666	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV12094896	60	2.18	0.984	4.831	0.0547	0.0584	AA	9	120	1.42	0.715	2.817	0.317	0.421
  hCV12094896	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV12094896	442	1.51	0.971	2.339	0.0674	0.0584	AG	57	927	1.19	0.854	1.66	0.3045	0.421
  hCV12094896	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV12094896	867	ref	.	.	.	0.0584	GG	89	1719	ref	.	.	.	0.421
  hCV12094896	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV12094896	502	1.59	1.046	2.414	0.0301	.	AG +	66	1047	1.22	0.885	1.673	0.2267	.
  							AA
  hCV12094896	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV12094896	60	1.86	0.861	4.034	0.1142	.	AA	9	120	1.33	0.679	2.609	0.4055	.
  hCV12094896	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1665834	91	2	1	3.985	0.05	0.1371	AA	13	190	1.3	0.721	2.339	0.3837	0.555
  hCV1665834	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1665834	541	1.24	0.795	1.933	0.344	0.1371	AG	66	1107	1.15	0.83	1.605	0.3942	0.555
  hCV1665834	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1665834	739	ref	.	.	.	0.1371	GG	76	1469	ref	.	.	.	0.555
  hCV1665834	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1665834	632	1.35	0.887	2.049	0.1622	.	AG +	79	1297	1.18	0.858	1.612	0.3124	.
  							AA
  hCV1665834	.	.	.	.	.	.		.	.	.	.	.	.	.
  hCV1665834	91	1.81	0.939	3.503	0.0764	.	AA	13	190	1.22	0.69	2.15	0.4957	.
  hCV1665834	.	.	.	.	.	.		.	.	.	.	.	.	.

• TABLE 21
  												GEN-	EV-	TO-
  					EV-	TO-					P_	O_	ENTS_	TAL_
  			GENO_		ENTS_	TAL_	HR_	L95_	U95_	P_	INT_	PLA-	PLA-	PLA-
  SNP hCV #	SNP rs #	MODE	RESP	STATIN	RESP	RESP	RESP	RESP	RESP	RESP	RESP	CEBO	CEBO	CEBO
  hCV2652047	rs873134	GEN	CC	Pravastatin	27	354	2.01	1.036	3.89	0.0391	0.00164	CC	13	338
  hCV2652047	rs873134	GEN	CC	Placebo	13	338	ref	.	.	.	0.00164		.	.
  hCV2652047	rs873134	GEN	CT	Pravastatin	24	680	0.5	0.308	0.818	0.0057	0.00164	CT	49	697
  hCV2652047	rs873134	GEN	CT	Placebo	49	697	ref	.	.	.	0.00164		.	.
  hCV2652047	rs873134	GEN	TT	Pravastatin	16	366	0.54	0.291	1.01	0.0538	0.00164	TT	26	336
  hCV2652047	rs873134	GEN	TT	Placebo	26	336	ref	.	.	.	0.00164		.	.
  hCV2652047	rs873134	DOM	CT + CC	Pravastatin	51	1034	0.83	0.571	1.199	0.3163	0.25372	CT +	62	1035
  												CC
  hCV2652047	rs873134	DOM	CT + CC	Placebo	62	1035	ref	.	.	.	0.25372		.	.
  hCV2652047	rs873134	REC	CT + TT	Pravastatin	40	1046	0.52	0.355	0.765	0.0009	0.00037	CC	13	338
  hCV2652047	rs873134	REC	CT + TT	Placebo	75	1033	ref	.	.	.	0.00037		.	.
  					P_									HW
  	HR_	L95_	U95_	P_	DF2_	GEN-	EV-	TO-					P_	(ALL)
  	PLA-	PLA-	PLA-	PLA-	PLA-	O_	ENTS_	TAL_	HR_	L95_	U95_	P_	DF2	p-
  SNP hCV #	CEBO	CEBO	CEBO	CEBO	CEBO	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL	Exact
  hCV2652047	0.48	0.248	0.939	0.032	0.0851	CC	40	692	0.96	0.626	1.488	0.8714	0.8089	0.761
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.	0.761
  hCV2652047	0.89	0.551	1.428	0.6225	0.0851	CT	73	1377	0.89	0.607	1.298	0.539	0.8089	0.761
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.	0.761
  hCV2652047	ref	.	.	.	0.0851	TT	42	702	ref	.	.	.	0.8089	0.761
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.	0.761
  hCV2652047	0.75	0.477	1.193	0.2284		CT +	113	2069	0.91	0.641	1.302	0.6173	.	0.761
  						CC
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.	0.761
  hCV2652047	0.52	0.29	0.942	0.0308		CC	40	692	1.04	0.728	1.494	0.8199	.	0.761
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.	0.761

• TABLE 22
  													EV-	TO-
  					EV-	TO-						GENO_	ENTS_	TAL_
  			GENO_		ENTS_	TAL_	HR_	L95_	U95_	P_	P_INT_	PLA-	PLA-	PLA-
  SNP hCV #	SNP rs #	MODE	RESP	STATIN	RESP	RESP	RESP	RESP	RESP	RESP	RESP	CEBO	CEBO	CEBO
  hCV2652047	rs873134	GEN	TT	Pravastatin	25	364	0.57	0.339	0.952	0.0317	0.05825	TT	37	333
  hCV2652047	rs873134	GEN	TT	Placebo	37	333	ref	.	.	.	0.05825		.	.
  hCV2652047	rs873134	GEN	TC	Pravastatin	63	676	1	0.705	1.405	0.9783	0.05825	TC	67	693
  hCV2652047	rs873134	GEN	TC	Placebo	67	693	ref	.	.	.	0.05825		.	.
  hCV2652047	rs873134	GEN	CC	Pravastatin	23	352	0.48	0.29	0.809	0.0056	0.05825	CC	42	335
  hCV2652047	rs873134	GEN	CC	Placebo	42	335	ref	.	.	.	0.05825		.	.
  hCV2652047	rs873134	DOM	TC + TT	Pravastatin	88	1040	0.85	0.64	1.133	0.2714	0.06887	TC + TT	104	1026
  hCV2652047	rs873134	DOM	TC + TT	Placebo	104	1026	ref	.	.	.	0.06887		.	.

  	HR_	L95_	U95_	P_	P_DF2_		EV-	TO-
  	PLA-	PLA-	PLA-	PLA-	PLA-	GENO_	ENTS_	TAL_	HR_	L95_	U95_	P_	P_DF2
  SNP hCV #	CEBO	CEBO	CEBO	CEBO	CEBO	ALL	ALL	ALL	ALL	ALL	ALL	ALL	ALL
  hCV2652047	0.87	0.555	1.349	0.5232	0.3415	TT	62	697	0.93	0.654	1.313	0.6696	0.8281
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.
  hCV2652047	0.75	0.509	1.105	0.1454	0.3415	TC	130	1369	1.02	0.756	1.372	0.9047	0.8281
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.
  hCV2652047	ref	.	.	.	0.3415	CC	65	687	ref	.	.	.	0.8281
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.
  hCV2652047	0.79	0.549	1.128	0.1924	.	TC + TT	192	2066	0.99	0.745	1.308	0.9269	.
  hCV2652047	.	.	.	.	.		.	.	.	.	.	.	.

Claims (32)

1. A method for determining whether a human's risk for cardiovascular disease (CVD) is reduced by treatment with an HMG-CoA reductase inhibitor, the method comprising testing nucleic acid from said human for the presence or absence of an allele at a polymorphism as represented by position 101 of any one of the nucleotide sequences of SEQ ID NOS:623-3661 or its complement, wherein the presence of said allele indicates said human's risk for CVD is reduced by treatment with said HMG-CoA reductase inhibitor.

2-3. (canceled)

4. The method of claim 1, wherein said HMG-CoA reductase inhibitor is a hydrophilic statin.

5. The method of claim 1, wherein said HMG-CoA reductase inhibitor is a hydrophobic statin.

6. The method of claim 1, wherein said HMG-CoA reductase inhibitor is selected from the group consisting of atorvastatin (Lipitor®), rosuvastatin (Crestor®), pravastatin (Pravachol®), simvastatin (Zocor®), fluvastatin (Lescol®), and lovastatin (Mevacor®), or any combination thereof.

7. The method of claim 1, wherein said HMG-CoA reductase inhibitor comprises an HMG-CoA reductase inhibitor in combination with at least one additional therapeutic agent.

8. The method of claim 7, wherein said HMG-CoA reductase inhibitor is selected from the group consisting of:

simvastatin in combination with ezetimibe (Vytorin®);

lovastatin in combination with niacin (Advicor®);

atorvastatin in combination with amlodipine besylate (Caduet®); and

simvastatin in combination with niacin (Simcor®).

9-12. (canceled)

13. The method of claim 1, wherein said testing comprises nucleic acid amplification.

14. The method of claim 13, wherein said nucleic acid amplification is carried out by polymerase chain reaction.

15. The method of claim 1, wherein said testing is performed using sequencing, 5′ nuclease digestion, molecular beacon assay, oligonucleotide ligation assay, size analysis, single-stranded conformation polymorphism analysis, or denaturing gradient gel electrophoresis (DGGE).

16. The method of claim 1, wherein said testing is performed using an allele-specific method.

17. The method of claim 16, wherein said allele-specific method is allele-specific probe hybridization, allele-specific primer extension, or allele-specific amplification.

18. (canceled)

19. The method of claim 1, wherein said human is homozygous for said allele.

20. The method of claim 1, wherein said human is heterozygous for said allele.

21. The method of claim 1, wherein said CVD is coronary heart disease (CHD).

22. The method of claim 21, wherein said CHD is myocardial infarction (MI).

23. The method of claim 1, wherein said CVD is stroke.

24. The method of claim 1, wherein said human did not have CVD prior to said testing.

25. The method of claim 1, wherein said human did have CVD prior to said testing.

26. The method of claim 1, further comprising administering an HMG-CoA reductase inhibitor to said human who has said allele.

27. The method of claim 1, further comprising administering a therapeutic agent that is not an HMG-CoA reductase inhibitor to said human who does not have said allele, wherein said therapeutic agent is selected from the group consisting of niacin, fibrates, and ezetimibe (Zetia® or Ezetrol®).

28. (canceled)

29. A method for determining whether a human has an increased risk for cardiovascular disease (CVD), comprising testing nucleic acid from said human for the presence or absence of an allele at a polymorphism as represented by position 101 of any one of the nucleotide sequences of SEQ ID NOS:623-3661 or its complement, wherein the presence of said allele indicates said human has an increased risk for CVD.

30. The method of claim 29, further comprising administering an HMG-CoA reductase inhibitor to said human who has said increased risk for CVD.

31. A method for reducing risk of cardiovascular disease (CVD) in a human, comprising administering to said human an effective amount of an HMG-CoA reductase inhibitor, wherein said human has been identified as having an allele at a polymorphism as represented by position 101 of any one of the nucleotide sequences of SEQ ID NOS:623-3661 or its complement, and wherein the presence of said allele indicates said human's risk for CVD is reduced by treatment with said HMG-CoA reductase inhibitor.

32. The method of claim 31, wherein said method comprises testing nucleic acid from said human for the presence or absence of said allele.

33-34. (canceled)

35. A detection reagent for carrying out the method of claim 1, wherein said detection reagent is an allele-specific probe or an allele-specific primer.

36. A test kit comprising one or more containers containing the detection reagent of claim 35 and one or more components selected from the group consisting of an enzyme, polymerase enzyme, ligase enzyme, buffer, amplification primer pair, dNTPs, ddNTPs, positive control nucleic acid, negative control, nucleic acid extraction reagent, and instructions for using said test kit which instruct that the presence of said allele indicates that said risk for CVD is reduced by treatment with said HMG-CoA reductase inhibitor.

37-38. (canceled)