US20160024497A1

US20160024497A1 - Compositions And Methods For Inhibiting Expression Of GSK-3 Genes

Info

Publication number: US20160024497A1
Application number: US14/698,109
Authority: US
Inventors: Dinah Wen-Yee Sah; Gregory Hinkle
Original assignee: Alnylam Pharmaceuticals Inc
Current assignee: Alnylam Pharmaceuticals Inc
Priority date: 2008-07-11
Filing date: 2015-04-28
Publication date: 2016-01-28
Also published as: WO2010006342A9; WO2010006342A2; US9029525B2; US20130012572A1; US20110184046A1; WO2010006342A3

Abstract

The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.

Description

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 13/615,164, filed Sep. 13, 2012 (allowed), which is a continuation of U.S. patent application Ser. No. 13/003,740 filed Jul. 13, 2009 (abandoned), which is a 371 national phase of PCT patent application serial number PCT/US2009/050432, filed Jul. 13, 2009, which claims the benefit of U.S. Provisional Application No. 61/080,153, filed Jul. 11, 2008, which are hereby incorporated in their entirety by reference.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

None.

SEQUENCE LISTING

The instant application contains a Sequence Listing which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Mar. 23, 2015, is named 29133_US_CRF_sequencelisting.txt, and is 4,165,632 bytes in size.

FIELD OF THE INVENTION

The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 alpha and/or beta (GSK-3 alpha and/or beta), and methods of using the dsRNA to inhibit expression of GSK-3. alpha and/or beta.

BACKGROUND OF THE INVENTION

Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine kinase. It functions as a key regulator of numerous signaling pathways. It phosphorylates and inactivates glycogen synthase, a key enzyme in glycogen metabolism. It has also been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. Two isoforms of GSK-3 have been reported in mammals: an approximately 51 kDa GSK-3 alpha form and an approximately 47 kDa GSK-3 beta form. These two isoforms exhibit about 98% homology in their kinase domains. Other regions share less homology: they share only about 36% identity in the last 76 C-terminal amino acid residues.
Double-stranded RNA molecules (dsRNA) have been shown to block gene expression in a highly conserved regulatory mechanism known as RNA interference (RNAi). WO 99/32619 (Fire et al.) disclosed the use of a dsRNA of at least 25 nucleotides in length to inhibit the expression of genes in C. elegans. dsRNA has also been shown to degrade target RNA in other organisms, including plants (see, e.g., WO 99/53050, Waterhouse et al.; and WO 99/61631, Heifetz et al.), Drosophila (see, e.g., Yang, D., et al., Curr. Biol. (2000) 10:1191-1200), and mammals (see WO 00/44895, Limmer; and DE 101 00 586.5, Kreutzer et al.).

SUMMARY OF THE INVENTION

The invention provides compositions containing double-stranded ribonucleic acid (dsRNA) targeted to a GSK-3 gene and methods for inhibiting the expression of a GSK-3 gene in a cell or mammal. The composition can inhibit GSK-3 alpha and/or GSK-3 beta. A composition that inhibits both can do so, e.g., by including a dsRNA that targets both GSK-3 alpha and GSK-3 beta, or by including a first dsRNA that inhibits GSK-3 alpha and a second dsRNA that inhibits GSK-3 beta. The composition can also include a dsRNA which inhibits both and a second which inhibits only one of the isoforms.
The invention also provides compositions and methods for treating manic depression (bipolar disorder).
Other disorders, e.g., pathological conditions and diseases caused by the expression of a GSK-3 gene, such as metabolic disorders (e.g., Type I or Type II diabetes or metabolic syndrome) and nervous system disorders, (e.g., CNS and nuerogenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's Disease, bipolar disorder, prion diseases (e.g., transmissible spongiform encephalopathies), stroke and schizophrenia). Compositions and methods for treating pathological conditions and diseases such as protozoan diseases (e.g., Plasmodium falciparum), cancer (e.g., colorectal cancer), and circadian rhythm diseases (e.g., sleep disorders, jet lag, and shift work), are also provided. The dsRNAs described herein can also be used to regulate skeletal muscle growth, inflammatory responses, platelet function, apoptosis, and cellular responses to DNA damage.
In one embodiment the invention provides a double-stranded ribonucleic acid (dsRNA), having a sense strand and an antisense strand, the sense strand comprising a first sequence and the antisense strand comprising a second sequence, the second sequence comprising a region complementary to an mRNA encoding a GSK-3 gene, and wherein said region of complementarity is less than 30 nucleotides in length. In some embodiments, the second sequence includes a region complementary to the GSK-3 gene sequences NM_—019884, NM_—00103166, :NM_—002093, or NM_—019827. In other embodiments, the second sequence includes a region complementary to at least 15 nucleotides of a target sequence described herein, e.g., in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. The second sequence can include a region complementary to a target sequence described in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
The antisense strand of the dsRNA of the invention can include at least 15 nucleotides of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. In one embodiment, the antisense strand includes one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. In another embodiment, the antisense strand consists of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
The sense strand can include at least 15 nucleotides of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. For example, the sense strand can include or can consist of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
In some embodiments, the dsRNA of the invention consists of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 and the antisense strand consists of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. Further embodiments include the duplexes disclosed herein, e.g., huGSKA-3, huGSKB-11, AD-18821, AD-18825, AD-18826, AD-18838, AD-18843, or AD-18844.
The dsRNA of the invention can include at least one modified nucleotide. Disclosed herein are exemplary modified sequences, but one of skill can readily design duplexes with different set of modifications using the sequences and teachings herein. The modified nucleotides can be, e.g., a 2′-O-methyl modified nucleotide, a nucleotide comprising a 5′-phosphorothioate group, or a terminal nucleotide linked to a cholesteryl derivative or dodecanoic acid bisdecylamide group. The modified nucleotide(s) can be a 2′-deoxy-2′-fluoro modified nucleotide, a 2′-deoxy-modified nucleotide, a locked nucleotide, an abasic nucleotide, 2′-amino-modified nucleotide, 2′-alkyl-modified nucleotide, morpholino nucleotide, a phosphoramidate, and a non-natural base comprising nucleotide. In one embodiment the dsRNA of the invention includes at least one 2′-O-methyl modified nucleotide and at least one nucleotide comprising a 5′-phosphorothioate group.
The region of complementarity of the dsRNA of the invention is less than 30 nucleotides, e.g., at least 15 nucleotides in length, or, e.g., between 19 and 21 nucleotides in length, or, e.g., 19 nucleotides in length.
Disclosed and claimed herein are methods for inhibiting expression of a GSK-3 gene. In one embodiment, administration of the dsRNA inhibits expression of GSK3 by more than 40%. In another embodiment the dsRNA exhibits an IC50 of less than or equal to 10 nM in suppressing GSK3. Alternatively, the dsRNA exhibits an IC50 of less than or equal to 1.0 nM in suppressing GSK3.
Also included in the invention are cells and vectors comprising the dsRNA of the invention.
Further contemplated is a pharmaceutical composition for inhibiting expression of an GSK-3 gene comprising a dsRNA of the invention.
Methods of inhibiting GSK-3 expression in a cell are included in the invention. The methods include (a) introducing into the cell the dsRNA of the invention; and (b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of a GSK-3 gene, thereby inhibiting expression of a GSK-3 gene in the cell.
Also included is a method of treating a disorder mediated by GSK-3 expression comprising administering to a human in need of such treatment a therapeutically effective amount of a dsRNA of the invention, including treatment of manic depression.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

These and other features, aspects, and advantages of the present invention will become better understood with regard to the following description, and accompanying drawings, where:

FIG. 1 is a graph illustrating the results of GSK3α mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA transfection.

FIG. 2 is a graph illustrating the results of GSK3β mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA transfection.

FIG. 3 is a graph illustrating the dose dependence of GSK3α mRNA suppression after siRNA transfection of HT22 cells.

FIG. 4 is a graph illustrating the dose dependence of GSK3 β mRNA suppression after siRNA transfection of HT22 cells.

FIG. 5 is a western blot illustrating protein levels after siRNA transfection in HT22 cells.

FIG. 6 is a graph illustrating GSK3β mRNA suppression in mouse nucleus accumbens after 14 day infusion of AD-18844 into the nucleus accumbens.

FIG. 7 is a graph illustrating GSK3α mRNA suppression in mouse nucleus accumbens after 14 day infusion of AD-18826 into the nucleus accumbens.

DETAILED DESCRIPTION OF THE INVENTION

The invention provides dsRNAs and methods of using the dsRNAs for inhibiting the expression of a GSK-3 gene in a cell or a mammal where the dsRNA targets a GSK-3 gene. The invention also provides compositions and methods for treating pathological conditions and diseases, such as a metabolic disease or a cardiovascular disease, in a mammal caused by the expression of a GSK-3 gene. dsRNA directs the sequence-specific degradation of mRNA through a process known as RNA interference (RNAi).
The dsRNAs of the compositions featured herein include an RNA strand (the antisense strand) having a region which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an mRNA transcript of a GSK-3 gene. The use of these dsRNAs enables the targeted degradation of mRNAs of genes that are implicated in replication and or maintenance of cancer cells in mammals. Very low dosages of GSK-3 dsRNAs in particular can specifically and efficiently mediate RNAi, resulting in significant inhibition of expression of the GSK-3 gene. The methods and compositions of the invention containing the GSK-3 dsRNA are useful for treating pathological processes mediated by GSK-3 expression, e.g., manic depression, or other disorders described herein.
The following detailed description discloses how to make and use the compositions containing dsRNAs to inhibit the expression of a GSK-3 gene, as well as compositions and methods for treating diseases and disorders caused by the expression of these genes, such as manic depression. The pharmaceutical compositions featured in the invention include a dsRNA having an antisense strand comprising a region of complementarity which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an RNA transcript of a GSK-3 gene, together with a pharmaceutically acceptable carrier. The compositions featured in the invention also include a dsRNA having an antisense strand having a region of complementarity which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an RNA transcript of a GSK-3 gene.
Accordingly, certain aspects of the invention provide pharmaceutical compositions containing the GSK-3 dsRNA and a pharmaceutically acceptable carrier, methods of using the compositions to inhibit expression of a GSK-3 gene, and methods of using the pharmaceutical compositions to treat diseases caused by expression of the GSK-3 gene.

I. DEFINITIONS

For convenience, the meaning of certain terms and phrases used in the specification, examples, and appended claims, are provided below. If there is an apparent discrepancy between the usage of a term in other parts of this specification and its definition provided in this section, the definition in this section shall prevail.
“G,” “C,” “A” and “U” each generally stand for a nucleotide that contains guanine, cytosine, adenine, and uracil as a base, respectively. “T” and “dT” are used interchangeably herein and refer to a deoxyribonucleotide wherein the nucleobase is thymine, e.g., deoxyribothymine. However, it will be understood that the term “ribonucleotide” or “nucleotide” or “deoxyribonucleotide” can also refer to a modified nucleotide, as further detailed below, or a surrogate replacement moiety. The skilled person is well aware that guanine, cytosine, adenine, and uracil may be replaced by other moieties without substantially altering the base pairing properties of an oligonucleotide comprising a nucleotide bearing such replacement moiety. For example, without limitation, a nucleotide comprising inosine as its base may base pair with nucleotides containing adenine, cytosine, or uracil. Hence, nucleotides containing uracil, guanine, or adenine may be replaced in the nucleotide sequences of the invention by a nucleotide containing, for example, inosine. Sequences comprising such replacement moieties are embodiments of the invention.
As used herein, “GSK-3” refers to Glycogen Synthase Kinase-3, which is also known as DKFZp686D0638, GSK3, C86142, GSK-3beta, 7330414F15Rik, and 8430431H08Rik. GSK-3 alpha sequence can be found as NCBI GeneID:2931 (human) and 606496 (mouse) and RefSeq ID number: NM_—019884 (human) and NM_—001031667 (mouse). GSK-3 beta sequence can be found as NCBI GeneID:2932 (human) and 56637 (mouse) and RefSeq ID number: NM_—002093 (human) and NM_—019827 (mouse). A dsRNA featured in the invention can target a specific GSK-3 isoform, e.g. GSK-3 alpha or GSK-3 beta, or a dsRNA of the invention can target both isoforms by binding to a common region of the mRNA transcript. A dsRNA featured in the invention can target a specific GSK-3 beta isoform, e.g. GSK-3 beta 1 or GSK-3 beta 2, or a dsRNA of the invention can target both isoforms by binding to a common region of the mRNA transcript.
As used herein, “target sequence” refers to a contiguous portion of the nucleotide sequence of an mRNA molecule formed during the transcription of a GSK-3 gene, including mRNA that is a product of RNA processing of a primary transcription product.
As used herein, the term “strand comprising a sequence” refers to an oligonucleotide comprising a chain of nucleotides that is described by the sequence referred to using the standard nucleotide nomenclature.
As used herein, and unless otherwise indicated, the term “complementary,” when used to describe a first nucleotide sequence in relation to a second nucleotide sequence, refers to the ability of an oligonucleotide or polynucleotide comprising the first nucleotide sequence to hybridize and form a duplex structure under certain conditions with an oligonucleotide or polynucleotide comprising the second nucleotide sequence, as will be understood by the skilled person. Such conditions can, for example, be stringent conditions, where stringent conditions may include: 400 mM NaCl, 40 mM PIPES pH 6.4, 1 mM EDTA, 50° C. or 70° C. for 12-16 hours followed by washing. Other conditions, such as physiologically relevant conditions as may be encountered inside an organism, can apply. The skilled person will be able to determine the set of conditions most appropriate for a test of complementarity of two sequences in accordance with the ultimate application of the hybridized nucleotides.
This includes base-pairing of the oligonucleotide or polynucleotide comprising the first nucleotide sequence to the oligonucleotide or polynucleotide comprising the second nucleotide sequence over the entire length of the first and second nucleotide sequence. Such sequences can be referred to as “fully complementary” with respect to each other herein. However, where a first sequence is referred to as “substantially complementary” with respect to a second sequence herein, the two sequences can be fully complementary, or they may form one or more, but generally not more than 4, 3 or 2 mismatched base pairs upon hybridization, while retaining the ability to hybridize under the conditions most relevant to their ultimate application. However, where two oligonucleotides are designed to form, upon hybridization, one or more single stranded overhangs, such overhangs shall not be regarded as mismatches with regard to the determination of complementarity. For example, a dsRNA comprising one oligonucleotide 21 nucleotides in length and another oligonucleotide 23 nucleotides in length, wherein the longer oligonucleotide comprises a sequence of 21 nucleotides that is fully complementary to the shorter oligonucleotide, may yet be referred to as “fully complementary” for the purposes of the invention.
“Complementary” sequences, as used herein, may also include, or be formed entirely from, non-Watson-Crick base pairs and/or base pairs formed from non-natural and modified nucleotides, in as far as the above requirements with respect to their ability to hybridize are fulfilled. Such non-Watson-Crick base pairs includes, but not limited to, G:U Wobble or Hoogstein base pairing.
The terms “complementary”, “fully complementary” and “substantially complementary” herein may be used with respect to the base matching between the sense strand and the antisense strand of a dsRNA, or between the antisense strand of a dsRNA and a target sequence, as will be understood from the context of their use.
As used herein, a polynucleotide which is “substantially complementary to at least part of” a messenger RNA (mRNA) refers to a polynucleotide which is substantially complementary to a contiguous portion of the mRNA of interest (e.g., encoding a GSK-3) including a 5′ UTR, an open reading frame (ORF), or a 3′ UTR. For example, a polynucleotide is complementary to at least a part of a GSK-3 mRNA if the sequence is substantially complementary to a non-interrupted portion of an mRNA encoding a GSK-3.
The term “double-stranded RNA” or “dsRNA”, as used herein, refers to a complex of ribonucleic acid molecules, having a duplex structure comprising two anti-parallel and substantially complementary, as defined above, nucleic acid strands. In general, the majority of nucleotides of each strand are ribonucleotides, but as described in detail herein, each or both strands can also include at least one non-ribonucleotide, e.g., a deoxyribonucleotide and/or a modified nucleotide. In addition, as used in this specification, “dsRNA” may include chemical modifications to ribonucleotides, including substantial modifications at multiple nucleotides and including all types of modifications disclosed herein or known in the art. Any such modifications, as used in an siRNA type molecule, are encompassed by “dsRNA” for the purposes of this specification and claims. The two strands forming the duplex structure may be different portions of one larger RNA molecule, or they may be separate RNA molecules. Where the two strands are part of one larger molecule, and therefore are connected by an uninterrupted chain of nucleotides between the 3′-end of one strand and the 5′end of the respective other strand forming the duplex structure, the connecting RNA chain is referred to as a “hairpin loop”. Where the two strands are connected covalently by means other than an uninterrupted chain of nucleotides between the 3′-end of one strand and the 5′end of the respective other strand forming the duplex structure, the connecting structure is referred to as a “linker”. The RNA strands may have the same or a different number of nucleotides. The maximum number of base pairs is the number of nucleotides in the shortest strand of the dsRNA minus any overhangs that are present in the duplex. In addition to the duplex structure, a dsRNA may comprise one or more nucleotide overhangs.
As used herein, a “nucleotide overhang” refers to the unpaired nucleotide or nucleotides that protrude from the duplex structure of a dsRNA when a 3′-end of one strand of the dsRNA extends beyond the 5′-end of the other strand, or vice versa. “Blunt” or “blunt end” means that there are no unpaired nucleotides at that end of the dsRNA, i.e., no nucleotide overhang. A “blunt ended” dsRNA is a dsRNA that is double-stranded over its entire length, i.e., no nucleotide overhang at either end of the molecule.
The term “antisense strand” refers to the strand of a dsRNA which includes a region that is substantially complementary to a target sequence. As used herein, the term “region of complementarity” refers to the region on the antisense strand that is substantially complementary to a sequence, for example a target sequence, as defined herein. Where the region of complementarity is not fully complementary to the target sequence, the mismatches are most tolerated in the terminal regions and, if present, are generally in a terminal region or regions, e.g., within 6, 5, 4, 3, or 2 nucleotides of the 5′ and/or 3′ terminus.
The term “sense strand,” as used herein, refers to the strand of a dsRNA that includes a region that is substantially complementary to a region of the antisense strand.
“Introducing into a cell”, when referring to a dsRNA, means facilitating uptake or absorption into the cell, as is understood by those skilled in the art. Absorption or uptake of dsRNA can occur through unaided diffusive or active cellular processes, or by auxiliary agents or devices. The meaning of this term is not limited to cells in vitro; a dsRNA may also be “introduced into a cell”, wherein the cell is part of a living organism. In such instance, introduction into the cell will include the delivery to the organism. For example, for in vivo delivery, dsRNA can be injected into a tissue site or administered systemically. In vitro introduction into a cell includes methods known in the art such as electroporation and lipofection.
The terms “silence” and “inhibit the expression of” “down-regulate the expression of,” “suppress the expression of” and the like in as far as they refer to a GSK-3 gene, herein refer to the at least partial suppression of the expression of a GSK-3 gene, as manifested by a reduction of the amount of mRNA which may be isolated from a first cell or group of cells in which a GSK-3 gene is transcribed and which has or have been treated such that the expression of a GSK-3 gene is inhibited, as compared to a second cell or group of cells substantially identical to the first cell or group of cells but which has or have not been so treated (control cells). The degree of inhibition is usually expressed in terms of
$\frac{(mRNA i n control cells) - (mRNA in treated cells)}{(mRNA in control cells)} •100 %$
Alternatively, the degree of inhibition may be given in terms of a reduction of a parameter that is functionally linked to GSK-3 gene transcription, e.g., the amount of protein encoded by a GSK-3 gene which is secreted by a cell, or the number of cells displaying a certain phenotype, e.g., apoptosis. In principle, GSK-3 gene silencing may be determined in any cell expressing the target, either constitutively or by genomic engineering, and by any appropriate assay. However, when a reference is needed in order to determine whether a given dsRNA inhibits the expression of the GSK-3 gene by a certain degree and therefore is encompassed by the instant invention, the assay provided in the Examples below shall serve as such reference.
For example, in certain instances, expression of a GSK-3 gene is suppressed by at least about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% by administration of the double-stranded oligonucleotide of the invention. In some embodiments, a GSK-3 gene is suppressed by at least about 60%, 70%, or 80% by administration of the double-stranded oligonucleotide of the invention. In some embodiments, a GSK-3 gene is suppressed by at least about 85%, 90%, or 95% by administration of the double-stranded oligonucleotide of the invention.
As used herein in the context of GSK-3 expression, the terms “treat”, “treatment”, and the like, refer to relief from or alleviation of pathological processes mediated by GSK-3 expression. In the context of the present invention insofar as it relates to any of the other conditions recited herein below (other than pathological processes mediated by GSK-3 expression), the terms “treat”, “treatment”, and the like mean to relieve or alleviate at least one symptom associated with such condition, or to slow or reverse the progression of such condition, such as the slowing and progression of manic depression.
As used herein, the phrases “therapeutically effective amount” and “prophylactically effective amount” refer to an amount that provides a therapeutic benefit in the treatment, prevention, or management of pathological processes mediated by GSK-3 expression or an overt symptom of pathological processes mediated by GSK-3 expression. The specific amount that is therapeutically effective can be readily determined by ordinary medical practitioner, and may vary depending on factors known in the art, such as, e.g. the type of pathological processes mediated by GSK-3 expression, the patient's history and age, the stage of pathological processes mediated by GSK-3 expression, and the administration of other anti-pathological processes mediated by GSK-3 expression agents.
As used herein, a “pharmaceutical composition” comprises a pharmacologically effective amount of a dsRNA and a pharmaceutically acceptable carrier. As used herein, “pharmacologically effective amount,” “therapeutically effective amount” or simply “effective amount” refers to that amount of an RNA effective to produce the intended pharmacological, therapeutic or preventive result. For example, if a given clinical treatment is considered effective when there is at least a 25% reduction in a measurable parameter associated with a disease or disorder, a therapeutically effective amount of a drug for the treatment of that disease or disorder is the amount necessary to effect at least a 25% reduction in that parameter.
The term “pharmaceutically acceptable carrier” refers to a carrier for administration of a therapeutic agent. Such carriers include, but are not limited to, saline, buffered saline, dextrose, water, glycerol, ethanol, and combinations thereof. The term specifically excludes cell culture medium. For drugs administered orally, pharmaceutically acceptable carriers include, but are not limited to pharmaceutically acceptable excipients such as inert diluents, disintegrating agents, binding agents, lubricating agents, sweetening agents, flavoring agents, coloring agents and preservatives. Suitable inert diluents include sodium and calcium carbonate, sodium and calcium phosphate, and lactose, while corn starch and alginic acid are suitable disintegrating agents. Binding agents may include starch and gelatin, while the lubricating agent, if present, will generally be magnesium stearate, stearic acid or talc. If desired, the tablets may be coated with a material such as glyceryl monostearate or glyceryl distearate, to delay absorption in the gastrointestinal tract.
As used herein, a “transformed cell” is a cell into which a vector has been introduced from which a dsRNA molecule may be expressed.

II. DOUBLE-STRANDED RIBONUCLEIC ACID (DSRNA)

As described in more detail herein, the invention provides double-stranded ribonucleic acid (dsRNA) molecules for inhibiting the expression of a GSK-3 gene in a cell or mammal, e.g., in a human having manic depression, or another disorder described herein, where the dsRNA includes an antisense strand having a region of complementarity which is complementary to at least a part of an mRNA formed in the expression of a GSK-3 gene, and where the region of complementarity is less than 30 nucleotides in length, and where said dsRNA, upon contact with a cell expressing a GSK-3 gene, inhibits the expression of a GSK-3 gene, e.g., by at least 30% as assayed by, for example, a PCR or branched DNA (bDNA) based method. The dsRNA of the invention may further include one or more single-stranded nucleotide overhangs.
The dsRNA can be synthesized by standard methods known in the art as further discussed below, e.g., by use of an automated DNA synthesizer, such as are commercially available from, for example, Biosearch, Applied Biosystems, Inc.
The dsRNA includes two RNA strands that are sufficiently complementary to hybridize to form a duplex structure. One strand of the dsRNA (the antisense strand) includes a region of complementarity that is substantially complementary, and generally fully complementary, to a target sequence, derived from the sequence of an mRNA formed during the expression of the GSK-3 gene, the other strand (the sense strand) includes a region that is complementary to the antisense strand, such that the two strands hybridize and form a duplex structure when combined under suitable conditions. Generally, the duplex structure is between 15 and 30, or between 25 and 30, or between 18 and 25, or between 19 and 24, or between 19 and 21, or 19, 20, or 21 base pairs in length. In one embodiment the duplex is 19 base pairs in length. In another embodiment the duplex is 21 base pairs in length. When two different siRNAs are used in combination, the duplex lengths can be identical or can differ.
Similarly, the region of complementarity to the target sequence can be between 15 and 30, or between 25 and 30, or between 18 and 25, or between 19 and 24, or between 19 and 21, or 19, 20, or 21 base pairs in length. In one embodiment the region of complementarity is 19 nucleotides in length. In another embodiment the region of complementarity is 21 nucleotides in length. When two different siRNAs are used in combination, the region of complementarity can be identical or can differ.
Each strand of the dsRNA of invention is generally between 15 and 30, or between 18 and 25, or 18, 19, 20, 21, 22, 23, 24, or 25 nucleotides in length. In other embodiments, each is strand is 25-30 nucleotides in length. Each strand of the duplex can be the same length or of different lengths. When two different siRNAs are used in combination, the lengths of each strand of each siRNA can be identical or can differ.
The dsRNA of the invention can include one or more single-stranded overhang(s) of one or more nucleotides. In one embodiment, at least one end of the dsRNA has a single-stranded nucleotide overhang of 1 to 4, generally 1 or 2 nucleotides. In another embodiment, the antisense strand of the dsRNA has 1-10 nucleotides overhangs each at the 3′ end and the 5′ end over the sense strand. In further embodiments, the sense strand of the dsRNA has 1-10 nucleotides overhangs each at the 3′ end and the 5′ end over the antisense strand.
A dsRNAs having at least one nucleotide overhang can have unexpectedly superior inhibitory properties than the blunt-ended counterpart. In some embodiments the presence of only one nucleotide overhang strengthens the interference activity of the dsRNA, without affecting its overall stability. A dsRNA having only one overhang has proven particularly stable and effective in vivo, as well as in a variety of cells, cell culture mediums, blood, and serum. Generally, the single-stranded overhang is located at the 3′-terminal end of the antisense strand or, alternatively, at the 3′-terminal end of the sense strand. The dsRNA can also have a blunt end, generally located at the 5′-end of the antisense strand. Such dsRNAs can have improved stability and inhibitory activity, thus allowing administration at low dosages, i.e., less than 5 mg/kg body weight of the recipient per day. Generally, the antisense strand of the dsRNA has a nucleotide overhang at the 3′-end, and the 5′-end is blunt. In another embodiment, one or more of the nucleotides in the overhang is replaced with a nucleoside thiophosphate.
In one embodiment, the targeted GSK-3 gene is the human GSK-3 gene. In another embodiment, the targeted GSK-3 gene is a mouse gene. In some embodiments, the sense strand of the dsRNA includes a sense sequence from Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, and the antisense sequence includes an antisense sequence of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. Alternative antisense agents that target elsewhere in the target sequence provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 can readily be determined using the target sequence and the flanking GSK-3 sequence.
The skilled person is well aware that dsRNAs comprising a duplex structure of between 20 and 23, but specifically 21, base pairs have been hailed as particularly effective in inducing RNA interference (Elbashir et al., EMBO 2001, 20:6877-6888). However, others have found that shorter or longer dsRNAs can be effective as well. In the embodiments described above, by virtue of the nature of the oligonucleotide sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, the dsRNAs of the invention can include at least one strand of a length of minimally 21 nt. It can be reasonably expected that shorter dsRNAs having one of the sequences of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 minus only a few nucleotides on one or both ends may be similarly effective as compared to the dsRNAs described above. Hence, dsRNAs having a partial sequence of at least 15, 16, 17, 18, 19, 20, or more contiguous nucleotides from one of the sequences of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, and differing in their ability to inhibit the expression of a GSK-3 gene in an assay as described herein below by not more than 5, 10, 15, 20, 25, or 30% inhibition from a dsRNA comprising the full sequence, are contemplated by the invention. Further dsRNAs that cleave within the target sequence provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 can readily be made using the GSK-3 sequence and the target sequence provided.
In addition, the siRNA agents provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 identify a site in a GSK-3 mRNA that is susceptible to siRNA based cleavage. As such the present invention further features siRNA agents that target within the sequence targeted by one of the agents of the present invention. As used herein a second siRNA agent is said to target within the sequence of a first siRNA agent if the second siRNA agent cleaves the message anywhere within the mRNA that is complementary to the antisense strand of the first siRNA agent. Such a second agent will generally consist of at least 15 contiguous nucleotides from one of the sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 coupled to additional nucleotide sequences taken from the region contiguous to the selected sequence in the GSK-3 gene. For example, the last 15 nucleotides of SEQ ID NO:1 combined with the next 6 nucleotides from the target GSK-3 gene produces a single strand agent of 21 nucleotides that is based on one of the sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.
The dsRNA of the invention can contain one or more mismatches to the target sequence. In a preferred embodiment, the dsRNA of the invention contains no more than 3 mismatches. If the antisense strand of the dsRNA contains mismatches to a target sequence, it is preferable that the area of mismatch not be located in the center of the region of complementarity. If the antisense strand of the dsRNA contains mismatches to the target sequence, it is preferable that the mismatch be restricted to 5 nucleotides from either end, for example 5, 4, 3, 2, or 1 nucleotide from either the 5′ or 3′ end of the region of complementarity. For example, for a 23 nucleotide dsRNA strand which is complementary to a region of the GSK-3 gene, the dsRNA generally does not contain any mismatch within the central 13 nucleotides. The methods described within the invention can be used to determine whether a dsRNA containing a mismatch to a target sequence is effective in inhibiting the expression of a GSK-3 gene. Consideration of the efficacy of dsRNAs with mismatches in inhibiting expression of a GSK-3 gene is important, especially if the particular region of complementarity in a GSK-3 gene is known to have polymorphic sequence variation within the population.
In some embodiments the sense and/or antisense sequences of the dsRNA molecules featured herein can have the primary sequence shown in the tables with or without the modifications shown in the tables. In other embodiments the dsRNA molecule can differ by not more than 1, 2 or 3 bases from that provided in the tables.
In one embodiment, at least one end of the dsRNA has a single-stranded nucleotide overhang of 1 to 4, generally 1 or 2 nucleotides. dsRNAs having at least one nucleotide overhang have superior inhibitory properties than their blunt-ended counterparts. The presence of only one nucleotide overhang strengthens the interference activity of the dsRNA, without affecting its overall stability. dsRNA having only one overhang has proven particularly stable and effective in vivo, as well as in a variety of cells, cell culture mediums, blood, and serum. Generally, the single-stranded overhang is located at the 3′-terminal end of the antisense strand or, alternatively, at the 3′-terminal end of the sense strand. The dsRNA may also have a blunt end, generally located at the 5′-end of the antisense strand. Such dsRNAs have improved stability and inhibitory activity, thus allowing administration at low dosages, i.e., less than 5 mg/kg body weight of the recipient per day. Generally, the antisense strand of the dsRNA has a nucleotide overhang at the 3′-end, and the 5′-end is blunt. In another embodiment, one or more of the nucleotides in the overhang is replaced with a nucleoside thiophosphate.
Modifications
In yet another embodiment, the dsRNA is chemically modified to enhance stability. The nucleic acids of the invention may be synthesized and/or modified by methods well established in the art, such as those described in “Current protocols in nucleic acid chemistry”, Beaucage, S. L. et al. (Edrs.), John Wiley & Sons, Inc., New York, N.Y., USA, which is hereby incorporated herein by reference. Specific examples of preferred dsRNA compounds useful in this invention include dsRNAs containing modified backbones or no natural internucleoside linkages. As defined in this specification, dsRNAs having modified backbones include those that retain a phosphorus atom in the backbone and those that do not have a phosphorus atom in the backbone. For the purposes of this specification, and as sometimes referenced in the art, modified dsRNAs that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleosides.
Preferred modified dsRNA backbones include, for example, phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3′-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3′-amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkylphosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3′-5′ linkages, 2′-5′ linked analogs of these, and those) having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3′-5′ to 5′-3′ or 2′-5′ to 5′-2′. Various salts, mixed salts and free acid forms are also included.
Representative U.S. patents that teach the preparation of the above phosphorus-containing linkages include, but are not limited to, U.S. Pat. Nos. 3,687,808; 4,469,863; 4,476,301; 5,023,243; 5,177,195; 5,188,897; 5,264,423; 5,276,019; 5,278,302; 5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455,233; 5,466,677; 5,476,925; 5,519,126; 5,536,821; 5,541,316; 5,550,111; 5,563,253; 5,571,799; 5,587,361; and 5,625,050, each of which is herein incorporated by reference
Preferred modified dsRNA backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatoms and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. These include those having morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulfone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulfamate backbones; methyleneimino and methylenehydrazino backbones; sulfonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH2 component parts.
Representative U.S. patents that teach the preparation of the above oligonucleosides include, but are not limited to, U.S. Pat. Nos. 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141; 5,235,033; 5,64,562; 5,264,564; 5,405,938; 5,434,257; 5,466,677; 5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596,086; 5,602,240; 5,608,046; 5,610,289; 5,618,704; 5,623,070; 5,663,312; 5,633,360; 5,677,437; and, 5,677,439, each of which is herein incorporated by reference.
In other preferred dsRNA mimetics, both the sugar and the internucleoside linkage, i.e., the backbone, of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. One such oligomeric compound, an dsRNA mimetic that has been shown to have excellent hybridization properties, is referred to as a peptide nucleic acid (PNA). In PNA compounds, the sugar backbone of an dsRNA is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza nitrogen atoms of the amide portion of the backbone. Representative U.S. patents that teach the preparation of PNA compounds include, but are not limited to, U.S. Pat. Nos. 5,539,082; 5,714,331; and 5,719,262, each of which is herein incorporated by reference. Further teaching of PNA compounds can be found in Nielsen et al., Science, 1991, 254, 1497-1500.
Most preferred embodiments of the invention are dsRNAs with phosphorothioate backbones and oligonucleosides with heteroatom backbones, and in particular —CH₂—NH—CH₂—, —CH₂—N(CH₃)—O—CH₂— [known as a methylene (methylimino) or MMI backbone], —CH₂—O—N(CH₃)—CH₂—, —CH₂—N(CH₃)—N(CH₃)—CH₂— and —N(CH₃)—CH₂—CH₂— [wherein the native phosphodiester backbone is represented as —O—P—O—CH₂—] of the above-referenced U.S. Pat. No. 5,489,677, and the amide backbones of the above-referenced U.S. Pat. No. 5,602,240. Also preferred are dsRNAs having morpholino backbone structures of the above-referenced U.S. Pat. No. 5,034,506.
Modified dsRNAs may also contain one or more substituted sugar moieties. Preferred dsRNAs comprise one of the following at the 2′ position: OH; F; O-, S-, or N-alkyl; O-, S-, or N-alkenyl; O-, S- or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C₁to C₁₀alkyl or C₂to C₁₀alkenyl and alkynyl. Particularly preferred are O[(CH₂)_nO]_mCH₃, O(CH₂)_nOCH₃, O(CH₂)_nNH₂, O(CH₂)_nCH₃, O(CH₂)_nONH₂, and O(CH₂)_nON[(CH₂)_nCH₃)]₂, where n and m are from 1 to about 10. Other preferred dsRNAs comprise one of the following at the 2′ position: C₁to C₁₀lower alkyl, substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH₃, OCN, Cl, Br, CN, CF₃, OCF₃, SOCH₃, SO₂CH₃, ONO₂, NO₂, N₃, NH₂, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an dsRNA, or a group for improving the pharmacodynamic properties of an dsRNA, and other substituents having similar properties. A preferred modification includes 2′-methoxyethoxy (2′-O—CH₂CH₂OCH₃, also known as 2′-O-(2-methoxyethyl) or 2′-MOE) (Martin et al., Helv. Chim. Acta, 1995, 78, 486-504) i.e., an alkoxy-alkoxy group. A further preferred modification includes 2′-dimethylaminooxyethoxy, i.e., a O(CH₂)₂ON(CH₃)₂group, also known as 2′-DMAOE, as described in examples herein below, and 2′-dimethylaminoethoxyethoxy (also known in the art as 2′-O-dimethylaminoethoxyethyl or 2′-DMAEOE), i.e., 2′-O—CH₂—O—CH₂—N(CH₂)₂, also described in examples herein below.
Other preferred modifications include 2′-methoxy (2′-OCH₃), 2′-aminopropoxy (2′-OCH₂CH₂CH₂NH₂) and 2′-fluoro (2′-F). Similar modifications may also be made at other positions on the dsRNA, particularly the 3′ position of the sugar on the 3′ terminal nucleotide or in 2′-5′ linked dsRNAs and the 5′ position of 5′ terminal nucleotide. DsRNAs may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar. Representative U.S. patents that teach the preparation of such modified sugar structures include, but are not limited to, U.S. Pat. Nos. 4,981,957; 5,118,800; 5,319,080; 5,359,044; 5,393,878; 5,446,137; 5,466,786; 5,514,785; 5,519,134; 5,567,811; 5,576,427; 5,591,722; 5,597,909; 5,610,300; 5,627,053; 5,639,873; 5,646,265; 5,658,873; 5,670,633; and 5,700,920, certain of which are commonly owned with the instant application, and each of which is herein incorporated by reference in its entirety.
DsRNAs may also include nucleobase (often referred to in the art simply as “base”) modifications or substitutions. As used herein, “unmodified” or “natural” nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl anal other 8-substituted adenines and guanines, 5-halo, particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-daazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808, those disclosed in The Concise Encyclopedia Of Polymer Science And Engineering, pages 858-859, Kroschwitz, J. L, ed. John Wiley & Sons, 1990, these disclosed by Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613, and those disclosed by Sanghvi, Y S., Chapter 15, DsRNA Research and Applications, pages 289-302, Crooke, S. T. and Lebleu, B., Ed., CRC Press, 1993. Certain of these nucleobases are particularly useful for increasing the binding affinity of the oligomeric compounds of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and 0-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2° C. (Sanghvi, Y. S., Crooke, S. T. and Lebleu, B., Eds., DsRNA Research and Applications, CRC Press, Boca Raton, 1993, pp. 276-278) and are presently preferred base substitutions, even more particularly when combined with 2′-O-methoxyethyl sugar modifications.
Representative U.S. patents that teach the preparation of certain of the above noted modified nucleobases as well as other modified nucleobases include, but are not limited to, the above noted U.S. Pat. No. 3,687,808, as well as U.S. Pat. Nos. 4,845,205; 5,130,30; 5,134,066; 5,175,273; 5,367,066; 5,432,272; 5,457,187; 5,459,255; 5,484,908; 5,502,177; 5,525,711; 5,552,540; 5,587,469; 5,594,121, 5,596,091; 5,614,617; and 5,681,941, each of which is herein incorporated by reference, and U.S. Pat. No. 5,750,692, also herein incorporated by reference.
Conjugates
Another modification of the dsRNAs of the invention involves chemically linking to the dsRNA one or more moieties or conjugates which enhance the activity, cellular distribution or cellular uptake of the dsRNA. Such moieties include but are not limited to lipid moieties such as a cholesterol moiety (Letsinger et al., Proc. Natl. Acid. Sci. USA, 199, 86, 6553-6556), cholic acid (Manoharan et al., Biorg. Med. Chem. Let., 1994 4 1053-1060), a thioether, e.g., beryl-S-tritylthiol (Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660, 306-309; Manoharan et al., Biorg. Med. Chem. Let., 1993, 3, 2765-2770), a thiocholesterol (Oberhauser et al., Nucl. Acids Res., 1992, 20, 533-538), an aliphatic chain, e.g., dodecandiol or undecyl residues (Saison-Behmoaras et al., EMBO J, 1991, 10, 1111-1118; Kabanov et al., FEBS Lett., 1990, 259, 327-330; Svinarchuk et al., Biochimie, 1993, 75, 49-54), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethyl-ammonium 1,2-di-O-hexadecyl-rac-glycero-3-Hphosphonate (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654; Shea et al., Nucl. Acids Res., 1990, 18, 3777-3783), a polyamine or a polyethylene glycol chain (Manoharan et al., Nucleosides & Nucleotides, 1995, 14, 969-973), or adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta, 1995, 1264, 229-237), or an octadecylamine or hexylamino-carbonyloxycholesterol moiety (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277, 923-937).
Representative U.S. patents that teach the preparation of such dsRNA conjugates include, but are not limited to, U.S. Pat. Nos. 4,828,979; 4,948,882; 5,218,105; 5,525,465; 5,541,313; 5,545,730; 5,552,538; 5,578,717, 5,580,731; 5,591,584; 5,109,124; 5,118,802; 5,138,045; 5,414,077; 5,486,603; 5,512,439; 5,578,718; 5,608,046; 4,587,044; 4,605,735; 4,667,025; 4,762,779; 4,789,737; 4,824,941; 4,835,263; 4,876,335; 4,904,582; 4,958,013; 5,082,830; 5,112,963; 5,214,136; 5,082,830; 5,112,963; 5,214,136; 5,245,022; 5,254,469; 5,258,506; 5,262,536; 5,272,250; 5,292,873; 5,317,098; 5,371,241, 5,391,723; 5,416,203, 5,451,463; 5,510,475; 5,512,667; 5,514,785; 5,565,552; 5,567,810; 5,574,142; 5,585,481; 5,587,371; 5,595,726; 5,597,696; 5,599,923; 5,599,928 and 5,688,941, each of which is herein incorporated by reference.
It is not necessary for all positions in a given compound to be uniformly modified, and in fact more than one of the aforementioned modifications may be incorporated in a single compound or even at a single nucleoside within an dsRNA. The present invention also includes dsRNA compounds which are chimeric compounds. “Chimeric” dsRNA compounds or “chimeras,” in the context of this invention, are dsRNA compounds, particularly dsRNAs, which contain two or more chemically distinct regions, each made up of at least one monomer unit, i.e., a nucleotide in the case of an dsRNA compound. These dsRNAs typically contain at least one region wherein the dsRNA is modified so as to confer upon the dsRNA increased resistance to nuclease degradation, increased cellular uptake, and/or increased binding affinity for the target nucleic acid. An additional region of the dsRNA may serve as a substrate for enzymes capable of cleaving RNA:DNA or RNA:RNA hybrids. By way of example, RNase H is a cellular endonuclease which cleaves the RNA strand of an RNA:DNAduplex. Activation of RNase H, therefore, results in cleavage of the RNA target, thereby greatly enhancing the efficiency of dsRNA inhibition of gene expression. Consequently, comparable results can often be obtained with shorter dsRNAs when chimeric dsRNAs are used, compared to phosphorothioate deoxy dsRNAs hybridizing to the same target region. Cleavage of the RNA target can be routinely detected by gel electrophoresis and, if necessary, associated nucleic acid hybridization techniques known in the art.
In certain instances, the dsRNA may be modified by a non-ligand group. A number of non-ligand molecules have been conjugated to dsRNAs in order to enhance the activity, cellular distribution or cellular uptake of the dsRNA, and procedures for performing such conjugations are available in the scientific literature. Such non-ligand moieties have included lipid moieties, such as cholesterol (Letsinger et al., Proc. Natl. Acad. Sci. USA, 1989, 86:6553), cholic acid (Manoharan et al., Bioorg. Med. Chem. Lett., 1994, 4:1053), a thioether, e.g., hexyl-S-tritylthiol (Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660:306; Manoharan et al., Bioorg. Med. Chem. Let., 1993, 3:2765), a thiocholesterol (Oberhauser et al., Nucl. Acids Res., 1992, 20:533), an aliphatic chain, e.g., dodecandiol or undecyl residues (Saison-Behmoaras et al., EMBO J., 1991, 10:111; Kabanov et al., FEBS Lett., 1990, 259:327; Svinarchuk et al., Biochimie, 1993, 75:49), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (Manoharan et al., Tetrahedron Lett., 1995, 36:3651; Shea et al., Nucl. Acids Res., 1990, 18:3777), a polyamine or a polyethylene glycol chain (Manoharan et al., Nucleosides & Nucleotides, 1995, 14:969), or adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995, 36:3651), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta, 1995, 1264:229), or an octadecylamine or hexylamino-carbonyl-oxycholesterol moiety (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277:923). Representative United States patents that teach the preparation of such dsRNA conjugates have been listed above. Typical conjugation protocols involve the synthesis of dsRNAs bearing an aminolinker at one or more positions of the sequence. The amino group is then reacted with the molecule being conjugated using appropriate coupling or activating reagents. The conjugation reaction may be performed either with the dsRNA still bound to the solid support or following cleavage of the dsRNA in solution phase. Purification of the dsRNA conjugate by HPLC typically affords the pure conjugate.
Vector Encoded siRNA Agents
In another aspect of the invention, GSK-3 specific dsRNA molecules that are expressed from transcription units inserted into DNA or RNA vectors (see, e.g., Couture, A, et al., TIG. (1996), 12:5-10; Skillern, A., et al., International PCT Publication No. WO 00/22113, Conrad, International PCT Publication No. WO 00/22114, and Conrad, U.S. Pat. No. 6,054,299). These transgenes can be introduced as a linear construct, a circular plasmid, or a viral vector, which can be incorporated and inherited as a transgene integrated into the host genome. The transgene can also be constructed to permit it to be inherited as an extrachromosomal plasmid (Gassmann, et al., Proc. Natl. Acad. Sci. USA (1995) 92:1292).
The individual strands of a dsRNA can be transcribed by promoters on two separate expression vectors and co-transfected into a target cell. Alternatively each individual strand of the dsRNA can be transcribed by promoters both of which are located on the same expression plasmid. In a preferred embodiment, a dsRNA is expressed as an inverted repeat joined by a linker polynucleotide sequence such that the dsRNA has a stem and loop structure.
The recombinant dsRNA expression vectors are generally DNA plasmids or viral vectors. dsRNA expressing viral vectors can be constructed based on, but not limited to, adeno-associated virus (for a review, see Muzyczka, et al., Curr. Topics Micro. Immunol. (1992) 158:97-129)); adenovirus (see, for example, Berkner, et al., BioTechniques (1998) 6:616), Rosenfeld et al. (1991, Science 252:431-434), and Rosenfeld et al. (1992), Cell 68:143-155)); or alphavirus as well as others known in the art. Retroviruses have been used to introduce a variety of genes into many different cell types, including epithelial cells, in vitro and/or in vivo (see, e.g., Eglitis, et al., Science (1985) 230:1395-1398; Danos and Mulligan, Proc. Natl. Acad. Sci. USA (1998) 85:6460-6464; Wilson et al., 1988, Proc. Natl. Acad. Sci. USA 85:3014-3018; Armentano et al., 1990, Proc. Natl. Acad. Sci. USA 87:61416145; Huber et al., 1991, Proc. Natl. Acad. Sci. USA 88:8039-8043; Ferry et al., 1991, Proc. Natl. Acad. Sci. USA 88:8377-8381; Chowdhury et al., 1991, Science 254:1802-1805; van Beusechem. et al., 1992, Proc. Nad. Acad. Sci. USA 89:7640-19; Kay et al., 1992, Human Gene Therapy 3:641-647; Dai et al., 1992, Proc. Natl. Acad. Sci. USA 89:10892-10895; Hwu et al., 1993, J. Immunol. 150:4104-4115; U.S. Pat. No. 4,868,116; U.S. Pat. No. 4,980,286; PCT Application WO 89/07136; PCT Application WO 89/02468; PCT Application WO 89/05345; and PCT Application WO 92/07573). Recombinant retroviral vectors capable of transducing and expressing genes inserted into the genome of a cell can be produced by transfecting the recombinant retroviral genome into suitable packaging cell lines such as PA317 and Psi-CRIP (Comette et al., 1991, Human Gene Therapy 2:5-10; Cone et al., 1984, Proc. Natl. Acad. Sci. USA 81:6349). Recombinant adenoviral vectors can be used to infect a wide variety of cells and tissues in susceptible hosts (e.g., rat, hamster, dog, and chimpanzee) (Hsu et al., 1992, J. Infectious Disease, 166:769), and also have the advantage of not requiring mitotically active cells for infection.
Any viral vector capable of accepting the coding sequences for the dsRNA molecule(s) to be expressed can be used, for example vectors derived from adenovirus (AV); adeno-associated virus (AAV); retroviruses (e.g., lentiviruses (LV), Rhabdoviruses, murine leukemia virus); herpes virus, and the like. The tropism of viral vectors can be modified by pseudotyping the vectors with envelope proteins or other surface antigens from other viruses, or by substituting different viral capsid proteins, as appropriate.
For example, lentiviral vectors of the invention can be pseudotyped with surface proteins from vesicular stomatitis virus (VSV), rabies, Ebola, Mokola, and the like. AAV vectors of the invention can be made to target different cells by engineering the vectors to express different capsid protein serotypes. For example, an AAV vector expressing a serotype 2 capsid on a serotype 2 genome is called AAV 2/2. This serotype 2 capsid gene in the AAV 2/2 vector can be replaced by a serotype 5 capsid gene to produce an AAV 2/5 vector. Techniques for constructing AAV vectors which express different capsid protein serotypes are within the skill in the art; see, e.g., Rabinowitz J E et al. (2002), J Virol 76:791-801, the entire disclosure of which is herein incorporated by reference.
Selection of recombinant viral vectors suitable for use in the invention, methods for inserting nucleic acid sequences for expressing the dsRNA into the vector, and methods of delivering the viral vector to the cells of interest are within the skill in the art. See, for example, Dornburg R (1995), Gene Therap. 2: 301-310; Eglitis M A (1988), Biotechniques 6: 608-614; Miller A D (1990), Hum Gene Therap. 1: 5-14; Anderson W F (1998), Nature 392: 25-30; and Rubinson D A et al., Nat. Genet. 33: 401-406, the entire disclosures of which are herein incorporated by reference.
Preferred viral vectors are those derived from AV and AAV. In a particularly preferred embodiment, the dsRNA of the invention is expressed as two separate, complementary single-stranded RNA molecules from a recombinant AAV vector having, for example, either the U6 or H1 RNA promoters, or the cytomegalovirus (CMV) promoter.
A suitable AV vector for expressing the dsRNA of the invention, a method for constructing the recombinant AV vector, and a method for delivering the vector into target cells, are described in Xia H et al. (2002), Nat. Biotech. 20: 1006-1010.
Suitable AAV vectors for expressing the dsRNA of the invention, methods for constructing the recombinant AV vector, and methods for delivering the vectors into target cells are described in Samulski R et al. (1987), J. Virol. 61: 3096-3101; Fisher K J et al. (1996), J. Virol, 70: 520-532; Samulski R et al. (1989), J. Virol. 63: 3822-3826; U.S. Pat. No. 5,252,479; U.S. Pat. No. 5,139,941; International Patent Application No. WO 94/13788; and International Patent Application No. WO 93/24641, the entire disclosures of which are herein incorporated by reference.
The promoter driving dsRNA expression in either a DNA plasmid or viral vector of the invention may be a eukaryotic RNA polymerase I (e.g. ribosomal RNA promoter), RNA polymerase II (e.g. CMV early promoter or actin promoter or U1 snRNA promoter) or generally RNA polymerase III promoter (e.g. U6 snRNA or 7SK RNA promoter) or a prokaryotic promoter, for example the T7 promoter, provided the expression plasmid also encodes T7 RNA polymerase required for transcription from a T7 promoter. The promoter can also direct transgene expression to the pancreas (see, e.g., the insulin regulatory sequence for pancreas (Bucchini et al., 1986, Proc. Natl. Acad. Sci. USA 83:2511-2515)).
In addition, expression of the transgene can be precisely regulated, for example, by using an inducible regulatory sequence and expression systems such as a regulatory sequence that is sensitive to certain physiological regulators, e.g., circulating glucose levels, or hormones (Docherty et al., 1994, FASEB J. 8:20-24). Such inducible expression systems, suitable for the control of transgene expression in cells or in mammals include regulation by ecdysone, by estrogen, progesterone, tetracycline, chemical inducers of dimerization, and isopropyl-beta-D1-thiogalactopyranoside (EPTG). A person skilled in the art would be able to choose the appropriate regulatory/promoter sequence based on the intended use of the dsRNA transgene.
Generally, recombinant vectors capable of expressing dsRNA molecules are delivered as described below, and persist in target cells. Alternatively, viral vectors can be used that provide for transient expression of dsRNA molecules. Such vectors can be repeatedly administered as necessary. Once expressed, the dsRNAs bind to target RNA and modulate its function or expression. Delivery of dsRNA expressing vectors can be systemic, such as by intravenous or intramuscular administration, by administration to target cells ex-planted from the patient followed by reintroduction into the patient, or by any other means that allows for introduction into a desired target cell.
dsRNA expression DNA plasmids are typically transfected into target cells as a complex with cationic lipid carriers (e.g. Oligofectamine) or non-cationic lipid-based carriers (e.g. Transit-TKO™). Multiple lipid transfections for dsRNA-mediated knockdowns targeting different regions of a single GSK-3 gene or two GSK-3 genes over a period of a week or more are also contemplated by the invention. Successful introduction of the vectors of the invention into host cells can be monitored using various known methods. For example, transient transfection. can be signaled with a reporter, such as a fluorescent marker, such as Green Fluorescent Protein (GFP). Stable transfection of ex vivo cells can be ensured using markers that provide the transfected cell with resistance to specific environmental factors (e.g., antibiotics and drugs), such as hygromycin B resistance.
The GSK-3 specific dsRNA molecules can also be inserted into vectors and used as gene therapy vectors for human patients. Gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see U.S. Pat. No. 5,328,470) or by stereotactic injection (see e.g., Chen et al. (1994) Proc. Natl. Acad. Sci. USA 91:3054-3057). The pharmaceutical preparation of the gene therapy vector can include the gene therapy vector in an acceptable diluent, or can include a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells, e.g., retroviral vectors, the pharmaceutical preparation can include one or more cells which produce the gene delivery system.

III. PHARMACEUTICAL COMPOSITIONS COMPRISING DSRNA

In one embodiment, the invention provides pharmaceutical compositions comprising a dsRNA, as described herein, and a pharmaceutically acceptable carrier. The pharmaceutical composition comprising the dsRNA is useful for treating a disease or disorder associated with the expression or activity of a GSK-3 gene, such as pathological processes mediated by GSK-3 expression. Such pharmaceutical compositions are formulated based on the mode of delivery. One example is compositions that are formulated for systemic administration via parenteral delivery.
The pharmaceutical compositions featured herein are administered in dosages sufficient to inhibit expression of a GSK-3 gene. In general, a suitable dose of dsRNA will be in the range of 0.01 to 200.0 milligrams per kilogram body weight of the recipient per day, generally in the range of 1 to 50 mg per kilogram body weight per day. For example, the dsRNA can be administered at 0.01 mg/kg, 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 3 mg/kg, 5.0 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, or 50 mg/kg per single dose.
The pharmaceutical composition may be administered once daily or the dsRNA may be administered as two, three, or more sub-doses at appropriate intervals throughout the day or even using continuous infusion or delivery through a controlled release formulation. In that case, the dsRNA contained in each sub-dose must be correspondingly smaller in order to achieve the total daily dosage. The dosage unit can also be compounded for delivery over several days, e.g., using a conventional sustained release formulation which provides sustained release of the dsRNA over a several day period. Sustained release formulations are well known in the art and are particularly useful for delivery of agents at a particular site, such as could be used with the agents of the present invention. In this embodiment, the dosage unit contains a corresponding multiple of the daily dose.
The skilled artisan will appreciate that certain factors may influence the dosage and timing required to effectively treat a subject, including but not limited to the severity of the disease or disorder, previous treatments, the general health and/or age of the subject, and other diseases present. Moreover, treatment of a subject with a therapeutically effective amount of a composition can include a single treatment or a series of treatments. Estimates of effective dosages and in vivo half-lives for the individual dsRNAs encompassed by the invention can be made using conventional methodologies or on the basis of in vivo testing using an appropriate animal model, as described elsewhere herein.
Advances in mouse genetics have generated a number of mouse models for the study of various human diseases, such as pathological processes mediated by GSK-3 expression. Such models are used for in vivo testing of dsRNA, as well as for determining a therapeutically effective dose.
The data obtained from cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of compositions featured in the invention lies generally within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the methods featured in the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range of the compound or, when appropriate, of the polypeptide product of a target sequence (e.g., achieving a decreased concentration of the polypeptide) that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.
The dsRNAs featured in the invention can be administered in combination with other known agents effective in treatment of pathological processes mediated by target gene expression. In any event, the administering physician can adjust the amount and timing of dsRNA administration on the basis of results observed using standard measures of efficacy known in the art or described herein.
Administration
The present invention also includes pharmaceutical compositions and formulations which include the dsRNA compounds of the invention. The pharmaceutical compositions of the present invention may be administered in a number of ways depending upon whether local or systemic treatment is desired and upon the area to be treated. Administration may be topical, pulmonary, e.g., by inhalation or insufflation of powders or aerosols, including by nebulizer; intratracheal, intranasal, epidermal and transdermal), oral or parenteral. Parenteral administration includes intravenous, intraarterial, subcutaneous, intraperitoneal or intramuscular injection or infusion; or intracranial, e.g., intrathecal or intraventricular, administration. In one embodiment, the pharmaceutical composition is administered intracranially, directly into the nucleus accumbens.
Pharmaceutical compositions and formulations for topical administration may include transdermal patches, ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders. Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable. Coated condoms, gloves and the like may also be useful. Preferred topical formulations include those in which the dsRNAs of the invention are in admixture with a topical delivery agent such as lipids, liposomes, fatty acids, fatty acid esters, steroids, chelating agents and surfactants. Preferred lipids and liposomes include neutral (e.g. dioleoylphosphatidyl DOPE ethanolamine, dimyristoylphosphatidyl choline DMPC, distearolyphosphatidyl choline) negative (e.g. dimyristoylphosphatidyl glycerol DMPG) and cationic (e.g. dioleoyltetramethylaminopropyl DOTAP and dioleoylphosphatidyl ethanolamine DOTMA). DsRNAs of the invention may be encapsulated within liposomes or may form complexes thereto, in particular to cationic liposomes. Alternatively, dsRNAs may be complexed to lipids, in particular to cationic lipids. Preferred fatty acids and esters include but are not limited arachidonic acid, oleic acid, eicosanoic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a C_1-10alkyl ester (e.g. isopropylmyristate IPM), monoglyceride, diglyceride or pharmaceutically acceptable salt thereof. Topical formulations are described in detail in U.S. patent application Ser. No. 09/315,298 filed on May 20, 1999 which is incorporated herein by reference in its entirety.
Compositions and formulations for oral administration include powders or granules, microparticulates, nanoparticulates, suspensions or solutions in water or non-aqueous media, capsules, gel capsules, sachets, tablets or minitablets. Thickeners, flavoring agents, diluents, emulsifiers, dispersing aids or binders may be desirable. Preferred oral formulations are those in which dsRNAs of the invention are administered in conjunction with one or more penetration enhancers surfactants and chelators. Preferred surfactants include fatty acids and/or esters or salts thereof, bile acids and/or salts thereof. Preferred bile acids/salts include chenodeoxycholic acid (CDCA) and ursodeoxychenodeoxycholic acid (UDCA), cholic acid, dehydrocholic acid, deoxycholic acid, glucholic acid, glycholic acid, glycodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, sodium tauro-24,25-dihydro-fusidate and sodium glycodihydrofusidate. Preferred fatty acids include arachidonic acid, undecanoic acid, oleic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a monoglyceride, a diglyceride or a pharmaceutically acceptable salt thereof (e.g. sodium). Also preferred are combinations of penetration enhancers, for example, fatty acids/salts in combination with bile acids/salts. A particularly preferred combination is the sodium salt of lauric acid, capric acid and UDCA. Further penetration enhancers include polyoxyethylene-9-lauryl ether, polyoxyethylene-20-cetyl ether. DsRNAs of the invention may be delivered orally, in granular form including sprayed dried particles, or complexed to form micro or nanoparticles. DsRNA complexing agents include poly-amino acids; polyimines; polyacrylates; polyalkylacrylates, polyoxethanes, polyalkylcyanoacrylates; cationized gelatins, albumins, starches, acrylates, polyethyleneglycols (PEG) and starches; polyalkylcyanoacrylates; DEAE-derivatized polyimines, pollulans, celluloses and starches. Particularly preferred complexing agents include chitosan, N-trimethylchitosan, poly-L-lysine, polyhistidine, polyornithine, polyspermines, protamine, polyvinylpyridine, polythiodiethylaminomethylethylene P(TDAE), polyaminostyrene (e.g. p-amino), poly(methylcyanoacrylate), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly(isobutylcyanoacrylate), poly(isohexylcynaoacrylate), DEAE-methacrylate, DEAE-hexylacrylate, DEAE-acrylamide, DEAE-albumin and DEAE-dextran, polymethylacrylate, polyhexylacrylate, poly(D,L-lactic acid), poly(DL-lactic-co-glycolic acid (PLGA), alginate, and polyethyleneglycol (PEG). Oral formulations for dsRNAs and their preparation are described in detail in U.S. application. Ser. No. 08/886,829 (filed Jul. 1, 1997), Ser. No. 09/108,673 (filed Jul. 1, 1998), Ser. No. 09/256,515 (filed Feb. 23, 1999), Ser. No. 09/082,624 (filed May 21, 1998) and Ser. No. 09/315,298 (filed May 20, 1999), each of which is incorporated herein by reference in their entirety.
Compositions and formulations for parenteral, intrathecal, intraventricular or intrahepatic administration may include sterile aqueous solutions which may also contain buffers, diluents and other suitable additives such as, but not limited to, penetration enhancers, carrier compounds and other pharmaceutically acceptable carriers or excipients.
Pharmaceutical compositions of the present invention include, but are not limited to, solutions, emulsions, and liposome-containing formulations. These compositions may be generated from a variety of components that include, but are not limited to, preformed liquids, self-emulsifying solids and self-emulsifying semisolids. Particularly preferred are formulations that target the liver when treating hepatic disorders such as hepatic carcinoma.
The pharmaceutical formulations of the present invention, which may conveniently be presented in unit dosage form, may be prepared according to conventional techniques well known in the pharmaceutical industry. Such techniques include the step of bringing into association the active ingredients with the pharmaceutical carrier(s) or excipient(s). In general, the formulations are prepared by uniformly and intimately bringing into association the active ingredients with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product.
The compositions of the present invention may be formulated into any of many possible dosage forms such as, but not limited to, tablets, capsules, gel capsules, liquid syrups, soft gels, suppositories, and enemas. The compositions of the present invention may also be formulated as suspensions in aqueous, non-aqueous or mixed media. Aqueous suspensions may further contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran. The suspension may also contain stabilizers.
Emulsions
The compositions of the present invention may be prepared and formulated as emulsions. Emulsions are typically heterogenous systems of one liquid dispersed in another in the form of droplets usually exceeding 0.1 μm in diameter (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199; Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., Volume 1, p. 245; Block in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 2, p. 335; Higuchi et al., in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 301). Emulsions are often biphasic systems comprising two immiscible liquid phases intimately mixed and dispersed with each other. In general, emulsions may be of either the water-in-oil (w/o) or the oil-in-water (o/w) variety. When an aqueous phase is finely divided into and dispersed as minute droplets into a bulk oily phase, the resulting composition is called a water-in-oil (w/o) emulsion. Alternatively, when an oily phase is finely divided into and dispersed as minute droplets into a bulk aqueous phase, the resulting composition is called an oil-in-water (o/w) emulsion. Emulsions may contain additional components in addition to the dispersed phases, and the active drug which may be present as a solution in either the aqueous phase, oily phase or itself as a separate phase. Pharmaceutical excipients such as emulsifiers, stabilizers, dyes, and anti-oxidants may also be present in emulsions as needed. Pharmaceutical emulsions may also be multiple emulsions that are comprised of more than two phases such as, for example, in the case of oil-in-water-in-oil (o/w/o) and water-in-oil-in-water (w/o/w) emulsions. Such complex formulations often provide certain advantages that simple binary emulsions do not. Multiple emulsions in which individual oil droplets of an o/w emulsion enclose small water droplets constitute a w/o/w emulsion. Likewise a system of oil droplets enclosed in globules of water stabilized in an oily continuous phase provides an o/w/o emulsion.
Emulsions are characterized by little or no thermodynamic stability. Often, the dispersed or discontinuous phase of the emulsion is well dispersed into the external or continuous phase and maintained in this form through the means of emulsifiers or the viscosity of the formulation. Either of the phases of the emulsion may be a semisolid or a solid, as is the case of emulsion-style ointment bases and creams. Other means of stabilizing emulsions entail the use of emulsifiers that may be incorporated into either phase of the emulsion. Emulsifiers may broadly be classified into four categories: synthetic surfactants, naturally occurring emulsifiers, absorption bases, and finely dispersed solids (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).
Synthetic surfactants, also known as surface active agents, have found wide applicability in the formulation of emulsions and have been reviewed in the literature (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), Marcel Dekker, Inc., New York, N. Y., 1988, volume 1, p. 199). Surfactants are typically amphiphilic and comprise a hydrophilic and a hydrophobic portion. The ratio of the hydrophilic to the hydrophobic nature of the surfactant has been termed the hydrophile/lipophile balance (HLB) and is a valuable tool in categorizing and selecting surfactants in the preparation of formulations. Surfactants may be classified into different classes based on the nature of the hydrophilic group: nonionic, anionic, cationic and amphoteric (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285).
Naturally occurring emulsifiers used in emulsion formulations include lanolin, beeswax, phosphatides, lecithin and acacia. Absorption bases possess hydrophilic properties such that they can soak up water to form w/o emulsions yet retain their semisolid consistencies, such as anhydrous lanolin and hydrophilic petrolatum. Finely divided solids have also been used as good emulsifiers especially in combination with surfactants and in viscous preparations. These include polar inorganic solids, such as heavy metal hydroxides, nonswelling clays such as bentonite, attapulgite, hectorite, kaolin, montmorillonite, colloidal aluminum silicate and colloidal magnesium aluminum silicate, pigments and nonpolar solids such as carbon or glyceryl tristearate.
A large variety of non-emulsifying materials are also included in emulsion formulations and contribute to the properties of emulsions. These include fats, oils, waxes, fatty acids, fatty alcohols, fatty esters, humectants, hydrophilic colloids, preservatives and antioxidants (Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).
Hydrophilic colloids or hydrocolloids include naturally occurring gums and synthetic polymers such as polysaccharides (for example, acacia, agar, alginic acid, carrageenan, guar gum, karaya gum, and tragacanth), cellulose derivatives (for example, carboxymethylcellulose and carboxypropylcellulose), and synthetic polymers (for example, carbomers, cellulose ethers, and carboxyvinyl polymers). These disperse or swell in water to form colloidal solutions that stabilize emulsions by forming strong interfacial films around the dispersed-phase droplets and by increasing the viscosity of the external phase.
Since emulsions often contain a number of ingredients such as carbohydrates, proteins, sterols and phosphatides that may readily support the growth of microbes, these formulations often incorporate preservatives. Commonly used preservatives included in emulsion formulations include methyl paraben, propyl paraben, quaternary ammonium salts, benzalkonium chloride, esters of p-hydroxybenzoic acid, and boric acid. Antioxidants are also commonly added to emulsion formulations to prevent deterioration of the formulation. Antioxidants used may be free radical scavengers such as tocopherols, alkyl gallates, butylated hydroxyanisole, butylated hydroxytoluene, or reducing agents such as ascorbic acid and sodium metabisulfite, and antioxidant synergists such as citric acid, tartaric acid, and lecithin.
The application of emulsion formulations via dermatological, oral and parenteral routes and methods for their manufacture have been reviewed in the literature (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199). Emulsion formulations for oral delivery have been very widely used because of ease of formulation, as well as efficacy from an absorption and bioavailability standpoint (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199). Mineral-oil base laxatives, oil-soluble vitamins and high fat nutritive preparations are among the materials that have commonly been administered orally as o/w emulsions.
In one embodiment of the present invention, the compositions of dsRNAs and nucleic acids are formulated as microemulsions. A microemulsion may be defined as a system of water, oil and amphiphile which is a single optically isotropic and thermodynamically stable liquid solution (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245). Typically microemulsions are systems that are prepared by first dispersing an oil in an aqueous surfactant solution and then adding a sufficient amount of a fourth component, generally an intermediate chain-length alcohol to form a transparent system. Therefore, microemulsions have also been described as thermodynamically stable, isotropically clear dispersions of two immiscible liquids that are stabilized by interfacial films of surface-active molecules (Leung and Shah, in: Controlled Release of Drugs: Polymers and Aggregate Systems, Rosoff, M., Ed., 1989, VCH Publishers, New York, pages 185-215). Microemulsions commonly are prepared via a combination of three to five components that include oil, water, surfactant, cosurfactant and electrolyte. Whether the microemulsion is of the water-in-oil (w/o) or an oil-in-water (o/w) type is dependent on the properties of the oil and surfactant used and on the structure and geometric packing of the polar heads and hydrocarbon tails of the surfactant molecules (Schott, in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 271).
The phenomenological approach utilizing phase diagrams has been extensively studied and has yielded a comprehensive knowledge, to one skilled in the art, of how to formulate microemulsions (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335). Compared to conventional emulsions, microemulsions offer the advantage of solubilizing water-insoluble drugs in a formulation of thermodynamically stable droplets that are formed spontaneously.
Surfactants used in the preparation of microemulsions include, but are not limited to, ionic surfactants, non-ionic surfactants, Brij 96, polyoxyethylene oleyl ethers, polyglycerol fatty acid esters, tetraglycerol monolaurate (ML310), tetraglycerol monooleate (MO310), hexaglycerol monooleate (PO310), hexaglycerol pentaoleate (PO500), decaglycerol monocaprate (MCA750), decaglycerol monooleate (MO750), decaglycerol sequioleate (SO750), decaglycerol decaoleate (DAO750), alone or in combination with cosurfactants. The cosurfactant, usually a short-chain alcohol such as ethanol, 1-propanol, and 1-butanol, serves to increase the interfacial fluidity by penetrating into the surfactant film and consequently creating a disordered film because of the void space generated among surfactant molecules. Microemulsions may, however, be prepared without the use of cosurfactants and alcohol-free self-emulsifying microemulsion systems are known in the art. The aqueous phase may typically be, but is not limited to, water, an aqueous solution of the drug, glycerol, PEG300, PEG400, polyglycerols, propylene glycols, and derivatives of ethylene glycol. The oil phase may include, but is not limited to, materials such as Captex 300, Captex 355, Capmul MCM, fatty acid esters, medium chain (C8-C12) mono, di, and tri-glycerides, polyoxyethylated glyceryl fatty acid esters, fatty alcohols, polyglycolized glycerides, saturated polyglycolized C8-C10 glycerides, vegetable oils and silicone oil.
Microemulsions are particularly of interest from the standpoint of drug solubilization and the enhanced absorption of drugs. Lipid based microemulsions (both o/w and w/o) have been proposed to enhance the oral bioavailability of drugs, including peptides (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385-1390; Ritschel, Meth. Find. Exp. Clin. Pharmacol., 1993, 13, 205). Microemulsions afford advantages of improved drug solubilization, protection of drug from enzymatic hydrolysis, possible enhancement of drug absorption due to surfactant-induced alterations in membrane fluidity and permeability, ease of preparation, ease of oral administration over solid dosage forms, improved clinical potency, and decreased toxicity (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385; Ho et al., J. Pharm. Sci., 1996, 85, 138-143). Often microemulsions may form spontaneously when their components are brought together at ambient temperature. This may be particularly advantageous when formulating thermolabile drugs, peptides or dsRNAs. Microemulsions have also been effective in the transdermal delivery of active components in both cosmetic and pharmaceutical applications. It is expected that the microemulsion compositions and formulations of the present invention will facilitate the increased systemic absorption of dsRNAs and nucleic acids from the gastrointestinal tract, as well as improve the local cellular uptake of dsRNAs and nucleic acids.
Microemulsions of the present invention may also contain additional components and additives such as sorbitan monostearate (Grill 3), Labrasol, and penetration enhancers to improve the properties of the formulation and to enhance the absorption of the dsRNAs and nucleic acids of the present invention. Penetration enhancers used in the microemulsions of the present invention may be classified as belonging to one of five broad categories—surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92). Each of these classes has been discussed above.
Liposomal Formulations
There are many organized surfactant structures besides microemulsions that have been studied and used for the formulation of drugs. These include monolayers, micelles, bilayers and vesicles. Vesicles, such as liposomes, have attracted great interest because of their specificity and the duration of action they offer from the standpoint of drug delivery. As used in the present invention, the term “liposome” means a vesicle composed of amphiphilic lipids arranged in a spherical bilayer or bilayers.
Liposomes are unilamellar or multilamellar vesicles which have a membrane formed from a lipophilic material and an aqueous interior. The aqueous portion contains the composition to be delivered. Cationic liposomes possess the advantage of being able to fuse to the cell wall. Non-cationic liposomes, although not able to fuse as efficiently with the cell wall, are taken up by macrophages in vivo.
In order to cross intact mammalian skin, lipid vesicles must pass through a series of fine pores, each with a diameter less than 50 nm, under the influence of a suitable transdermal gradient. Therefore, it is desirable to use a liposome which is highly deformable and able to pass through such fine pores.
Further advantages of liposomes include; liposomes obtained from natural phospholipids are biocompatible and biodegradable; liposomes can incorporate a wide range of water and lipid soluble drugs; liposomes can protect encapsulated drugs in their internal compartments from metabolism and degradation (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245). Important considerations in the preparation of liposome formulations are the lipid surface charge, vesicle size and the aqueous volume of the liposomes.
Liposomes are useful for the transfer and delivery of active ingredients to the site of action. Because the liposomal membrane is structurally similar to biological membranes, when liposomes are applied to a tissue, the liposomes start to merge with the cellular membranes and as the merging of the liposome and cell progresses, the liposomal contents are emptied into the cell where the active agent may act.
Liposomal formulations have been the focus of extensive investigation as the mode of delivery for many drugs. There is growing evidence that for topical administration, liposomes present several advantages over other formulations. Such advantages include reduced side-effects related to high systemic absorption of the administered drug, increased accumulation of the administered drug at the desired target, and the ability to administer a wide variety of drugs, both hydrophilic and hydrophobic, into the skin.
Several reports have detailed the ability of liposomes to deliver agents including high-molecular weight DNA into the skin. Compounds including analgesics, antibodies, hormones and high-molecular weight DNAs have been administered to the skin. The majority of applications resulted in the targeting of the upper epidermis
Liposomes fall into two broad classes. Cationic liposomes are positively charged liposomes which interact with the negatively charged DNA molecules to form a stable complex. The positively charged DNA/liposome complex binds to the negatively charged cell surface and is internalized in an endosome. Due to the acidic pH within the endosome, the liposomes are ruptured, releasing their contents into the cell cytoplasm (Wang et al., Biochem. Biophys. Res. Commun., 1987, 147, 980-985).
Liposomes which are pH-sensitive or negatively-charged, entrap DNA rather than complex with it. Since both the DNA and the lipid are similarly charged, repulsion rather than complex formation occurs. Nevertheless, some DNA is entrapped within the aqueous interior of these liposomes. pH-sensitive liposomes have been used to deliver DNA encoding the thymidine kinase gene to cell monolayers in culture. Expression of the exogenous gene was detected in the target cells (Zhou et al., Journal of Controlled Release, 1992, 19, 269-274).
One major type of liposomal composition includes phospholipids other than naturally-derived phosphatidylcholine. Neutral liposome compositions, for example, can be formed from dimyristoyl phosphatidylcholine (DMPC) or dipalmitoyl phosphatidylcholine (DPPC). Anionic liposome compositions generally are formed from dimyristoyl phosphatidylglycerol, while anionic fusogenic liposomes are formed primarily from dioleoyl phosphatidylethanolamine (DOPE). Another type of liposomal composition is formed from phosphatidylcholine (PC) such as, for example, soybean PC, and egg PC. Another type is formed from mixtures of phospholipid and/or phosphatidylcholine and/or cholesterol.
Several studies have assessed the topical delivery of liposomal drug formulations to the skin. Application of liposomes containing interferon to guinea pig skin resulted in a reduction of skin herpes sores while delivery of interferon via other means (e.g., as a solution or as an emulsion) were ineffective (Weiner et al., Journal of Drug Targeting, 1992, 2, 405-410). Further, an additional study tested the efficacy of interferon administered as part of a liposomal formulation to the administration of interferon using an aqueous system, and concluded that the liposomal formulation was superior to aqueous administration (du Plessis et al., Antiviral Research, 1992, 18, 259-265).
Non-ionic liposomal systems have also been examined to determine their utility in the delivery of drugs to the skin, in particular systems comprising non-ionic surfactant and cholesterol. Non-ionic liposomal formulations comprising Novasome™ I (glyceryl dilaurate/cholesterol/po-lyoxyethylene-10-stearyl ether) and Novasome™ II (glyceryl distearate/cholesterol/polyoxyethylene-10-stearyl ether) were used to deliver cyclosporin-A into the dermis of mouse skin. Results indicated that such non-ionic liposomal systems were effective in facilitating the deposition of cyclosporin-A into different layers of the skin (Hu et al. S. T. P. Pharma. Sci., 1994, 4, 6, 466).
Liposomes also include “sterically stabilized” liposomes, a term which, as used herein, refers to liposomes comprising one or more specialized lipids that, when incorporated into liposomes, result in enhanced circulation lifetimes relative to liposomes lacking such specialized lipids. Examples of sterically stabilized liposomes are those in which part of the vesicle-forming lipid portion of the liposome (A) comprises one or more glycolipids, such as monosialoganglioside G_M1, or (B) is derivatized with one or more hydrophilic polymers, such as a polyethylene glycol (PEG) moiety. While not wishing to be bound by any particular theory, it is thought in the art that, at least for sterically stabilized liposomes containing gangliosides, sphingomyelin, or PEG-derivatized lipids, the enhanced circulation half-life of these sterically stabilized liposomes derives from a reduced uptake into cells of the reticuloendothelial system (RES) (Allen et al., FEBS Letters, 1987, 223, 42; Wu et al., Cancer Research, 1993, 53, 3765).
Various liposomes comprising one or more glycolipids are known in the art. Papahadjopoulos et al. (Ann. N.Y. Acad. Sci., 1987, 507, 64) reported the ability of monosialoganglioside G_M1, galactocerebroside sulfate and phosphatidylinositol to improve blood half-lives of liposomes. These findings were expounded upon by Gabizon et al. (Proc. Natl. Acad. Sci. U.S.A., 1988, 85, 6949). U.S. Pat. No. 4,837,028 and WO 88/04924, both to Allen et al., disclose liposomes comprising (1) sphingomyelin and (2) the ganglioside G_M1or a galactocerebroside sulfate ester. U.S. Pat. No. 5,543,152 (Webb et al.) discloses liposomes comprising sphingomyelin. Liposomes comprising 1,2-sn-dimyristoylphosphat-idylcholine are disclosed in WO 97/13499 (Lim et al).
Many liposomes comprising lipids derivatized with one or more hydrophilic polymers, and methods of preparation thereof, are known in the art. Sunamoto et al. (Bull. Chem. Soc. Jpn., 1980, 53, 2778) described liposomes comprising a nonionic detergent, 2C_1215G, that contains a PEG moiety. Illum et al. (FEBS Lett., 1984, 167, 79) noted that hydrophilic coating of polystyrene particles with polymeric glycols results in significantly enhanced blood half-lives. Synthetic phospholipids modified by the attachment of carboxylic groups of polyalkylene glycols (e.g., PEG) are described by Sears (U.S. Pat. Nos. 4,426,330 and 4,534,899). Klibanov et al. (FEBS Lett., 1990, 268, 235) described experiments demonstrating that liposomes comprising phosphatidylethanolamine (PE) derivatized with PEG or PEG stearate have significant increases in blood circulation half-lives. Blume et al. (Biochimica et Biophysica Acta, 1990, 1029, 91) extended such observations to other PEG-derivatized phospholipids, e.g., DSPE-PEG, formed from the combination of distearoylphosphatidylethanolamine (DSPE) and PEG. Liposomes having covalently bound PEG moieties on their external surface are described in European Patent No. EP 0 445 131 B1 and WO 90/04384 to Fisher. Liposome compositions containing 1-20 mole percent of PE derivatized with PEG, and methods of use thereof, are described by Woodle et al. (U.S. Pat. Nos. 5,013,556 and 5,356,633) and Martin et al. (U.S. Pat. No. 5,213,804 and European Patent No. EP 0 496 813 B1). Liposomes comprising a number of other lipid-polymer conjugates are disclosed in WO 91/05545 and U.S. Pat. No. 5,225,212 (both to Martin et al.) and in WO 94/20073 (Zalipsky et al.) Liposomes comprising PEG-modified ceramide lipids are described in WO 96/10391 (Choi et al). U.S. Pat. No. 5,540,935 (Miyazaki et al.) and U.S. Pat. No. 5,556,948 (Tagawa et al.) describe PEG-containing liposomes that can be further derivatized with functional moieties on their surfaces.
A number of liposomes comprising nucleic acids are known in the art. WO 96/40062 to Thierry et al. discloses methods for encapsulating high molecular weight nucleic acids in liposomes. U.S. Pat. No. 5,264,221 to Tagawa et al. discloses protein-bonded liposomes and asserts that the contents of such liposomes may include a dsRNA. U.S. Pat. No. 5,665,710 to Rahman et al. describes certain methods of encapsulating oligodeoxynucleotides in liposomes. WO 97/04787 to Love et al. discloses liposomes comprising dsRNAs targeted to the raf gene.
Transfersomes are yet another type of liposomes, and are highly deformable lipid aggregates which are attractive candidates for drug delivery vehicles. Transfersomes may be described as lipid droplets which are so highly deformable that they are easily able to penetrate through pores which are smaller than the droplet. Transfersomes are adaptable to the environment in which they are used, e.g., they are self-optimizing (adaptive to the shape of pores in the skin), self-repairing, frequently reach their targets without fragmenting, and often self-loading. To make transfersomes it is possible to add surface edge-activators, usually surfactants, to a standard liposomal composition. Transfersomes have been used to deliver serum albumin to the skin. The transfersome-mediated delivery of serum albumin has been shown to be as effective as subcutaneous injection of a solution containing serum albumin.
Surfactants find wide application in formulations such as emulsions (including microemulsions) and liposomes. The most common way of classifying and ranking the properties of the many different types of surfactants, both natural and synthetic, is by the use of the hydrophile/lipophile balance (HLB). The nature of the hydrophilic group (also known as the “head”) provides the most useful means for categorizing the different surfactants used in formulations (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N. Y., 1988, p. 285).
If the surfactant molecule is not ionized, it is classified as a nonionic surfactant. Nonionic surfactants find wide application in pharmaceutical and cosmetic products and are usable over a wide range of pH values. In general their HLB values range from 2 to about 18 depending on their structure. Nonionic surfactants include nonionic esters such as ethylene glycol esters, propylene glycol esters, glyceryl esters, polyglyceryl esters, sorbitan esters, sucrose esters, and ethoxylated esters. Nonionic alkanolamides and ethers such as fatty alcohol ethoxylates, propoxylated alcohols, and ethoxylated/propoxylated block polymers are also included in this class. The polyoxyethylene surfactants are the most popular members of the nonionic surfactant class.
If the surfactant molecule carries a negative charge when it is dissolved or dispersed in water, the surfactant is classified as anionic. Anionic surfactants include carboxylates such as soaps, acyl lactylates, acyl amides of amino acids, esters of sulfuric acid such as alkyl sulfates and ethoxylated alkyl sulfates, sulfonates such as alkyl benzene sulfonates, acyl isethionates, acyl taurates and sulfosuccinates, and phosphates. The most important members of the anionic surfactant class are the alkyl sulfates and the soaps.
If the surfactant molecule carries a positive charge when it is dissolved or dispersed in water, the surfactant is classified as cationic. Cationic surfactants include quaternary ammonium salts and ethoxylated amines. The quaternary ammonium salts are the most used members of this class.
If the surfactant molecule has the ability to carry either a positive or negative charge, the surfactant is classified as amphoteric. Amphoteric surfactants include acrylic acid derivatives, substituted alkylamides, N-alkylbetaines and phosphatides.
The use of surfactants in drug products, formulations and in emulsions has been reviewed (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N. Y., 1988, p. 285).
Nucleic Acid Lipid Particles
In one embodiment, a dsRNA featured in the invention is fully encapsulated in the lipid formulation to form a SPLP, pSPLP, SNALP, or other nucleic acid-lipid particle. As used herein, the term “SNALP” refers to a stable nucleic acid-lipid particle, including SPLP. As used herein, the term “SPLP” refers to a nucleic acid-lipid particle comprising plasmid DNA encapsulated within a lipid vesicle. SNALPs and SPLPs typically contain a cationic lipid, a non-cationic lipid, and a lipid that prevents aggregation of the particle (e.g., a PEG-lipid conjugate). SNALPs and SPLPs are extremely useful for systemic applications, as they exhibit extended circulation lifetimes following intravenous (i.v.) injection and accumulate at distal sites (e.g., sites physically separated from the administration site). SPLPs include “pSPLP,” which include an encapsulated condensing agent-nucleic acid complex as set forth in PCT Publication No. WO 00/03683. The particles of the present invention typically have a mean diameter of about 50 nm to about 150 nm, more typically about 60 nm to about 130 nm, more typically about 70 nm to about 110 nm, most typically about 70 to about 90 nm, and are substantially nontoxic. In addition, the nucleic acids when present in the nucleic acid-lipid particles of the present invention are resistant in aqueous solution to degradation with a nuclease. Nucleic acid-lipid particles and their method of preparation are disclosed in, e.g., U.S. Pat. Nos. 5,976,567; 5,981,501; 6,534,484; 6,586,410; 6,815,432; and PCT Publication No. WO 96/40964.
In one embodiment, the lipid to drug ratio (mass/mass ratio) (e.g., lipid to dsRNA ratio) will be in the range of from about 1:1 to about 50:1, from about 1:1 to about 25:1, from about 3:1 to about 15:1, from about 4:1 to about 10:1, from about 5:1 to about 9:1, or about 6:1 to about 9:1.
The cationic lipid may be, for example, N,N-dioleyl-N,N-dimethylammonium chloride (DODAC), N,N-distearyl-N,N-dimethylammonium bromide (DDAB), N—(I-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTAP), N—(I-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTMA), N,N-dimethyl-2,3-dioleyloxy)propylamine (DODMA), 1,2-DiLinoleyloxy-N,N-dimethylaminopropane (DLinDMA), 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLenDMA), 1,2-Dilinoleylcarbamoyloxy-3-dimethylaminopropane (DLin-C-DAP), 1,2-Dilinoleyoxy-3-(dimethylamino)acetoxypropane (DLin-DAC), 1,2-Dilinoleyoxy-3-morpholinopropane (DLin-MA), 1,2-Dilinoleoyl-3-dimethylaminopropane (DLinDAP), 1,2-Dilinoleylthio-3-dimethylaminopropane (DLin-S-DMA), 1-Linoleoyl-2-linoleyloxy-3-dimethylaminopropane (DLin-2-DMAP), 1,2-Dilinoleyloxy-3-trimethylaminopropane chloride salt (DLin-TMA.Cl), 1,2-Dilinoleoyl-3-trimethylaminopropane chloride salt (DLin-TAP.Cl), 1,2-Dilinoleyloxy-3-(N-methylpiperazino)propane (DLin-MPZ), or 3-(N,N-Dilinoleylamino)-1,2-propanediol (DLinAP), 3-(N,N-Dioleylamino)-1,2-propanedio (DOAP), 1,2-Dilinoleyloxo-3-(2-N,N-dimethylamino)ethoxypropane (DLin-EG-DMA), 2,2-Dilinoleyl-4-dimethylaminomethyl-[1,3]-dioxolane (DLin-K-DMA) or analogs thereof, or a mixture thereof. The cationic lipid may comprise from about 20 mol % to about 50 mol % or about 40 mol % of the total lipid present in the particle.
In another embodiment, the compound 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane can be used to prepare lipid-siRNA nanoparticles. Synthesis of 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane is described in U.S. provisional patent application No. 61/107,998 filed on Oct. 23, 2008, which is herein incorporated by reference.
In one embodiment, the lipid-siRNA particle includes 40% 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane: 10% DSPC: 40% Cholesterol: 10% PEG-C-DOMG (mole percent) with a particle size of 63.0±20 nm and a 0.027 siRNA/Lipid Ratio.
The non-cationic lipid may be an anionic lipid or a neutral lipid including, but not limited to, distearoylphosphatidylcholine (DSPC), dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylglycerol (DOPG), dipalmitoylphosphatidylglycerol (DPPG), dioleoyl-phosphatidylethanolamine (DOPE), palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylethanolamine (POPE), dioleoyl-phosphatidylethanolamine 4-(N-maleimidomethyl)-cyclohexane-1-carboxylate (DOPE-mal), dipalmitoyl phosphatidyl ethanolamine (DPPE), dimyristoylphosphoethanolamine (DMPE), distearoyl-phosphatidyl-ethanolamine (DSPE), 16-O-monomethyl PE, 16-O-dimethyl PE, 18-1-trans PE, 1-stearoyl-2-oleoyl-phosphatidyethanolamine (SOPE), cholesterol, or a mixture thereof. The non-cationic lipid may be from about 5 mol % to about 90 mol %, about 10 mol %, or about 58 mol % if cholesterol is included, of the total lipid present in the particle.
The conjugated lipid that inhibits aggregation of particles may be, for example, a polyethyleneglycol (PEG)-lipid including, without limitation, a PEG-diacylglycerol (DAG), a PEG-dialkyloxypropyl (DAA), a PEG-phospholipid, a PEG-ceramide (Cer), or a mixture thereof. The PEG-DAA conjugate may be, for example, a PEG-dilauryloxypropyl (Ci₂), a PEG-dimyristyloxypropyl (Ci₄), a PEG-dipalmityloxypropyl (Ci₆), or a PEG-distearyloxypropyl (C]₈). The conjugated lipid that prevents aggregation of particles may be from 0 mol % to about 20 mol % or about 2 mol % of the total lipid present in the particle.
In some embodiments, the nucleic acid-lipid particle further includes cholesterol at, e.g., about 10 mol % to about 60 mol % or about 48 mol % of the total lipid present in the particle.
LNP01
In one embodiment, the lipidoid ND98.4HCl (MW 1487) (Formula 1), Cholesterol (Sigma-Aldrich), and PEG-Ceramide C16 (Avanti Polar Lipids) can be used to prepare lipid-siRNA nanoparticles (i.e., LNP01 particles). Stock solutions of each in ethanol can be prepared as follows: ND98, 133 mg/ml; Cholesterol, 25 mg/ml, PEG-Ceramide C16, 100 mg/ml. The ND98, Cholesterol, and PEG-Ceramide C16 stock solutions can then be combined in a, e.g., 42:48:10 molar ratio. The combined lipid solution can be mixed with aqueous siRNA (e.g., in sodium acetate pH 5) such that the final ethanol concentration is about 35-45% and the final sodium acetate concentration is about 100-300 mM. Lipid-siRNA nanoparticles typically form spontaneously upon mixing. Depending on the desired particle size distribution, the resultant nanoparticle mixture can be extruded through a polycarbonate membrane (e.g., 100 nm cut-off) using, for example, a thermobarrel extruder, such as Lipex Extruder (Northern Lipids, Inc). In some cases, the extrusion step can be omitted. Ethanol removal and simultaneous buffer exchange can be accomplished by, for example, dialysis or tangential flow filtration. Buffer can be exchanged with, for example, phosphate buffered saline (PBS) at about pH 7, e.g., about pH 6.9, about pH 7.0, about pH 7.1, about pH 7.2, about pH 7.3, or about pH 7.4.
LNP01 formulations are described, e.g., in International Application Publication No. WO 2008/042973, which is hereby incorporated by reference.
As mentioned above, the lipid-dsRNA particle can comprise a cationic lipid, a neutral lipid, a steroid, and optionally a lipid that prevents aggregation of the particle. The relative percentages of these constituents can vary depending on the type of lipids used. However, in general, the cationic lipid comprises from about 20 mol % to about 70 mol % or about 40 mol % to about 60 mol % of the total lipid present in the particle; neutral lipids comprise from about 5 mol % to about 90 mol %, about 10 mol %, or about 58 mol % if cholesterol is included, of the total lipid present in the particle; the steroid (typically cholesterol) can comprise from about 10 mol % to about 60 mol % or about 48 mol % of the total lipid present in the particle; finally, the lipid that prevents aggregation of the particle, typically a conjugated lipid (e.g., a PEG-conjugated lipid) can comprise from 0 mol % to about 20 mol % or about 2 mol % of the total lipid present in the particle.
In one embodiment, the lipid-dsRNA particle includes 40 mol % 2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane, 10 mol % 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 40 mol % Cholesterol, 10 mol % PEG-C-DOMG with a particle size of 63.0±20 nm and a 0.027 dsRNA/Lipid Ratio.
In another embodiment, the lipid-dsRNA particle includes 40 mol % 1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane (DLinDMA), 10 mol % 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 2 mol % 3-N-[(qmethoxypoly(ethylene glycol)2000)carbamoyl]-1,2-dimyristyloxy-propylamine (PEG-C-DMA), and 48 mol % cholesterol.
In another embodiment, the lipid-dsRNA particle includes 57.1 mol % 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLinDMA), 7.1 mol % DPPC, 34.4 mol % Cholesterol, 1.4 mol % PEG-cDMA.
In another embodiment, the lipid-dsRNA particle includes 48 mol % cholesterol, 20 mol % of the neutral lipid 1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA (3-N-[(methoxy poly(ethylene glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol % of the cationic lipid DLinDMA (1,2-dilinoleyloxy-3-(N,N-dimethyl)aminopropane).
In another embodiment, the lipid-dsRNA particle includes 48 mol % cholesterol, 20 mol % of the neutral lipid 1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA (3-N-[(methoxy poly(ethylene glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol % of the cationic lipid 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane.
Additional exemplary lipid-siRNA formulations are as follows:


		cationic lipid/non-cationic lipid//
		choleseterol/PEG-lipid conjugate
	Cationic Lipid	Lipid:siRNA ratio	Process

LNP05	2,2-Dilinoleyl-4-	XTC/DSPC/Cholesterol/PEG-DMG	Extrusion
	dimethylaminoethyl-	57.5/7.5/31.5/3.5
	[1,3]-dioxolane (XTC)	lipid:siRNA ~6:1
LNP06	2,2-Dilinoleyl-4-	XTC/DSPC/Cholesterol/PEG-DMG	Extrusion
	dimethylaminoethyl-	57.5/7.5/31.5/3.5
	[1,3]-dioxolane (XTC)	lipid:siRNA ~11:1
LNP07	2,2-Dilinoleyl-4-	XTC/DSPC/Cholesterol/PEG-DMG	In-line
	dimethylaminoethyl-	60/7.5/31/1.5,	mixing
	[1,3]-dioxolane (XTC)	lipid:siRNA ~6:1
LNP08	2,2-Dilinoleyl-4-	XTC/DSPC/Cholesterol/PEG-DMG	In-line
	dimethylaminoethyl-	60/7.5/31/1.5,	mixing
	[1,3]-dioxolane (XTC)	lipid:siRNA ~11:1
LNP09	2,2-Dilinoleyl-4-	XTC/DSPC/Cholesterol/PEG-DMG	In-line
	dimethylaminoethyl-	50/10/38.5/1.5	mixing
	[1,3]-dioxolane (XTC)	Lipid:siRNA 10:1
SNALP	1,2-Dilinolenyloxy-	DLinDMA/DPPC/Cholesterol/PEG-cDMA
	N,N-	(57.1/7.1/34.4/1.4)
	dimethylaminopropane	lipid:siRNA ~7:1
	(DLinDMA)
SNALP-	2,2-Dilinoleyl-4-	XTC/DPPC/Cholesterol/PEG-cDMA
XTC	dimethylaminoethyl-	57.1/7.1/34.4/1.4
	[1,3]-dioxolane (XTC)	lipid:siRNA ~7:1

Characterization of Lipid Formulated dsRNAs
Formulations prepared by either the in-line mixing or extrusion-free method can be characterized in similar manners. For example, formulations are typically characterized by visual inspection. They should be whitish translucent solutions free from aggregates or sediment. Particle size and particle size distribution of lipid-nanoparticles can be measured by light scattering using, for example, a Malvern Zetasizer Nano ZS (Malvern, USA). Particles should be about 20-300 nm, such as 40-100 nm in size. The particle size distribution should be unimodal. The total siRNA concentration in the formulation, as well as the entrapped fraction, is estimated using a dye exclusion assay. A sample of the formulated siRNA can be incubated with an RNA-binding dye, such as Ribogreen (Molecular Probes) in the presence or absence of a formulation disrupting surfactant, e.g., 0.5% Triton-X100. The total siRNA in the formulation can be determined by the signal from the sample containing the surfactant, relative to a standard curve. The entrapped fraction is determined by subtracting the “free” siRNA content (as measured by the signal in the absence of surfactant) from the total siRNA content. Percent entrapped siRNA is typically >85%. For SNALP formulation, the particle size is at least 30 nm, at least 40 nm, at least 50 nm, at least 60 nm, at least 70 nm, at least 80 nm, at least 90 nm, at least 100 nm, at least 110 nm, and at least 120 nm. The suitable range is typically about at least 50 nm to about at least 110 nm, about at least 60 nm to about at least 100 nm, or about at least 80 nm to about at least 90 nm.
Penetration Enhancers
In one embodiment, the present invention employs various penetration enhancers to effect the efficient delivery of nucleic acids, particularly dsRNAs, to the skin of animals. Most drugs are present in solution in both ionized and nonionized forms. However, usually only lipid soluble or lipophilic drugs readily cross cell membranes. It has been discovered that even non-lipophilic drugs may cross cell membranes if the membrane to be crossed is treated with a penetration enhancer. In addition to aiding the diffusion of non-lipophilic drugs across cell membranes, penetration enhancers also enhance the permeability of lipophilic drugs.
Penetration enhancers may be classified as belonging to one of five broad categories, i.e., surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92). Each of the above mentioned classes of penetration enhancers are described below in greater detail.
Surfactants: In connection with the present invention, surfactants (or “surface-active agents”) are chemical entities which, when dissolved in an aqueous solution, reduce the surface tension of the solution or the interfacial tension between the aqueous solution and another liquid, with the result that absorption of dsRNAs through the mucosa is enhanced. In addition to bile salts and fatty acids, these penetration enhancers include, for example, sodium lauryl sulfate, polyoxyethylene-9-lauryl ether and polyoxyethylene-20-cetyl ether) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92); and perfluorochemical emulsions, such as FC-43. Takahashi et al., J. Pharm. Pharmacol., 1988, 40, 252).
Fatty acids: Various fatty acids and their derivatives which act as penetration enhancers include, for example, oleic acid, lauric acid, capric acid (n-decanoic acid), myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein (1-monooleoyl-rac-glycerol), dilaurin, caprylic acid, arachidonic acid, glycerol 1-monocaprate, 1-dodecylazacycloheptan-2-one, acylcarnitines, acylcholines, C.sub.1-10 alkyl esters thereof (e.g., methyl, isopropyl and t-butyl), and mono- and di-glycerides thereof (i.e., oleate, laurate, caprate, myristate, palmitate, stearate, linoleate, etc.) (Lee et al., Critical Reviews in Therapeutic Drug Carryier Systems, 1991, p. 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; El Hariri et al., J. Pharm. Pharmacol., 1992, 44, 651-654).
Bile salts: The physiological role of bile includes the facilitation of dispersion and absorption of lipids and fat-soluble vitamins (Brunton, Chapter 38 in: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Ed., Hardman et al. Eds., McGraw-Hill, New York, 1996, pp. 934-935). Various natural bile salts, and their synthetic derivatives, act as penetration enhancers. Thus the term “bile salts” includes any of the naturally occurring components of bile as well as any of their synthetic derivatives. The bile salts of the invention include, for example, cholic acid (or its pharmaceutically acceptable sodium salt, sodium cholate), dehydrocholic acid (sodium dehydrocholate), deoxycholic acid (sodium deoxycholate), glucholic acid (sodium glucholate), glycholic acid (sodium glycocholate), glycodeoxycholic acid (sodium glycodeoxycholate), taurocholic acid (sodium taurocholate), taurodeoxycholic acid (sodium taurodeoxycholate), chenodeoxycholic acid (sodium chenodeoxycholate), ursodeoxycholic acid (UDCA), sodium tauro-24,25-dihydro-fusidate (STDHF), sodium glycodihydrofusidate and polyoxyethylene-9-lauryl ether (POE) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Swinyard, Chapter 39 In: Remington's Pharmaceutical Sciences, 18th Ed., Gennaro, ed., Mack Publishing Co., Easton, Pa., 1990, pages 782-783; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Yamamoto et al., J. Pharm. Exp. Ther., 1992, 263, 25; Yamashita et al., J. Pharm. Sci., 1990, 79, 579-583).
Chelating Agents: Chelating agents, as used in connection with the present invention, can be defined as compounds that remove metallic ions from solution by forming complexes therewith, with the result that absorption of dsRNAs through the mucosa is enhanced. With regards to their use as penetration enhancers in the present invention, chelating agents have the added advantage of also serving as DNase inhibitors, as most characterized DNA nucleases require a divalent metal ion for catalysis and are thus inhibited by chelating agents (Jarrett, J. Chromatogr., 1993, 618, 315-339). Chelating agents of the invention include but are not limited to disodium ethylenediaminetetraacetate (EDTA), citric acid, salicylates (e.g., sodium salicylate, 5-methoxysalicylate and homovanilate), N-acyl derivatives of collagen, laureth-9 and N-amino acyl derivatives of beta-diketones (enamines)(Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Buur et al., J. Control Rel., 1990, 14, 43-51).
Non-chelating non-surfactants: As used herein, non-chelating non-surfactant penetration enhancing compounds can be defined as compounds that demonstrate insignificant activity as chelating agents or as surfactants but that nonetheless enhance absorption of dsRNAs through the alimentary mucosa (Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33). This class of penetration enhancers include, for example, unsaturated cyclic ureas, 1-alkyl- and 1-alkenylazacyclo-alkanone derivatives (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92); and non-steroidal anti-inflammatory agents such as diclofenac sodium, indomethacin and phenylbutazone (Yamashita et al., J. Pharm. Pharmacol., 1987, 39, 621-626).
Agents that enhance uptake of dsRNAs at the cellular level may also be added to the pharmaceutical and other compositions of the present invention. For example, cationic lipids, such as lipofectin (Junichi et al, U.S. Pat. No. 5,705,188), cationic glycerol derivatives, and polycationic molecules, such as polylysine (Lollo et al., PCT Application WO 97/30731), are also known to enhance the cellular uptake of dsRNAs.
Other agents may be utilized to enhance the penetration of the administered nucleic acids, including glycols such as ethylene glycol and propylene glycol, pyrrols such as 2-pyrrol, azones, and terpenes such as limonene and menthone.
Carriers
Certain compositions of the present invention also incorporate carrier compounds in the formulation. As used herein, “carrier compound” or “carrier” can refer to a nucleic acid, or analog thereof, which is inert (i.e., does not possess biological activity per se) but is recognized as a nucleic acid by in vivo processes that reduce the bioavailability of a nucleic acid having biological activity by, for example, degrading the biologically active nucleic acid or promoting its removal from circulation. The coadministration of a nucleic acid and a carrier compound, typically with an excess of the latter substance, can result in a substantial reduction of the amount of nucleic acid recovered in the liver, kidney or other extracirculatory reservoirs, presumably due to competition between the carrier compound and the nucleic acid for a common receptor. For example, the recovery of a partially phosphorothioate dsRNA in hepatic tissue can be reduced when it is coadministered with polyinosinic acid, dextran sulfate, polycytidic acid or 4-acetamido-4′isothiocyano-stilbene-2,2′-disulfonic acid (Miyao et al., DsRNA Res. Dev., 1995, 5, 115-121; Takakura et al., DsRNA & Nucl. Acid Drug Dev., 1996, 6, 177-183.
Excipients
In contrast to a carrier compound, a “pharmaceutical carrier” or “excipient” is a pharmaceutically acceptable solvent, suspending agent or any other pharmacologically inert vehicle for delivering one or more nucleic acids to an animal. The excipient may be liquid or solid and is selected, with the planned manner of administration in mind, so as to provide for the desired bulk, consistency, etc., when combined with a nucleic acid and the other components of a given pharmaceutical composition. Typical pharmaceutical carriers include, but are not limited to, binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose, etc.); fillers (e.g., lactose and other sugars, microcrystalline cellulose, pectin, gelatin, calcium sulfate, ethyl cellulose, polyacrylates or calcium hydrogen phosphate, etc.); lubricants (e.g., magnesium stearate, talc, silica, colloidal silicon dioxide, stearic acid, metallic stearates, hydrogenated vegetable oils, corn starch, polyethylene glycols, sodium benzoate, sodium acetate, etc.); disintegrants (e.g., starch, sodium starch glycolate, etc.); and wetting agents (e.g., sodium lauryl sulphate, etc).
Pharmaceutically acceptable organic or inorganic excipient suitable for non-parenteral administration which do not deleteriously react with nucleic acids can also be used to formulate the compositions of the present invention. Suitable pharmaceutically acceptable carriers include, but are not limited to, water, salt solutions, alcohols, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.
Formulations for topical administration of nucleic acids may include sterile and non-sterile aqueous solutions, non-aqueous solutions in common solvents such as alcohols, or solutions of the nucleic acids in liquid or solid oil bases. The solutions may also contain buffers, diluents and other suitable additives. Pharmaceutically acceptable organic or inorganic excipients suitable for non-parenteral administration which do not deleteriously react with nucleic acids can be used.
Suitable pharmaceutically acceptable excipients include, but are not limited to, water, salt solutions, alcohol, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.
Other Components
The compositions of the present invention may additionally contain other adjunct components conventionally found in pharmaceutical compositions, at their art-established usage levels. Thus, for example, the compositions may contain additional, compatible, pharmaceutically-active materials such as, for example, antipruritics, astringents, local anesthetics or anti-inflammatory agents, or may contain additional materials useful in physically formulating various dosage forms of the compositions of the present invention, such as dyes, flavoring agents, preservatives, antioxidants, opacifiers, thickening agents and stabilizers. However, such materials, when added, should not unduly interfere with the biological activities of the components of the compositions of the present invention. The formulations can be sterilized and, if desired, mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure, buffers, colorings, flavorings and/or aromatic substances and the like which do not deleteriously interact with the nucleic acid(s) of the formulation.
Aqueous suspensions may contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran. The suspension may also contain stabilizers.
Certain embodiments of the invention provide pharmaceutical compositions containing (a) one or more antisense compounds and (b) one or more other chemotherapeutic agents which function by a non-antisense mechanism. Examples of such chemotherapeutic agents include but are not limited to daunorubicin, daunomycin, dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide, ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D, mithramycin, prednisone, hydroxyprogesterone, testosterone, tamoxifen, dacarbazine, procarbazine, hexamethylmelamine, pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea, nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea, deoxycoformycin, 4-hydroxyperoxycyclophosphor-amide, 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine, taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate, irinotecan, topotecan, gemcitabine, teniposide, cisplatin and diethylstilbestrol (DES). See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228, Berkow et al., eds., Rahway, N.J. When used with the compounds of the invention, such chemotherapeutic agents may be used individually (e.g., 5-FU and oligonucleotide), sequentially (e.g., 5-FU and oligonucleotide for a period of time followed by MTX and oligonucleotide), or in combination with one or more other such chemotherapeutic agents (e.g., 5-FU, MTX and oligonucleotide, or 5-FU, radiotherapy and oligonucleotide). Anti-inflammatory drugs, including but not limited to nonsteroidal anti-inflammatory drugs and corticosteroids, and antiviral drugs, including but not limited to ribivirin, vidarabine, acyclovir and ganciclovir, may also be combined in compositions of the invention. See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed., Berkow et al., eds., 1987, Rahway, N.J., pages 2499-2506 and 46-49, respectively). Other non-antisense chemotherapeutic agents are also within the scope of this invention. Two or more combined compounds may be used together or sequentially.
Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Compounds which exhibit high therapeutic indices are preferred.
The data obtained from cell culture assays and animal studies can be used in formulation a range of dosage for use in humans. The dosage of compositions of the invention lies generally within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range of the compound or, when appropriate, of the polypeptide product of a target sequence (e.g., achieving a decreased concentration of the polypeptide) that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.
In addition to their administration, as discussed above, the dsRNAs featured in the invention can be administered in combination with other known agents effective in treatment of pathological processes mediated by GSK-3 expression. In any event, the administering physician can adjust the amount and timing of dsRNA administration on the basis of results observed using standard measures of efficacy known in the art or described herein.
Methods for Treating Diseases Caused by Expression of a GSK-3 Gene
The invention relates in particular to the use of a dsRNA targeting GSK-3 and compositions containing at least one such dsRNA, for the treatment of a GSK-3-mediated disorder or disease. For example, a dsRNA targeting a GSK-3 gene can be useful for the treatment of manic depression.
Other disorders which can be treated with the compounds, compositions and methods described herein include a metabolic disease, such as metabolic disorders (e.g., Type I or Type II diabetes or metabolic syndrome) and nervous system disorders, (e.g., CNS or nuerogenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's Disease, prion diseases (e.g., transmissible spongiform encephalopathies), stroke and schizophrenia). Compositions and methods for treating pathological conditions and diseases such as protozoan diseases (e.g., Plasmodium falciparum), cancer (e.g., colorectal cancer), and circadian rhythm diseases (e.g., sleep disorders, jet lag, and shift work), and are also provided. The dsRNAs described here can also be used to regulate skeletal muscle growth, inflammatory responses, platelet function, apoptosis, and cellular responses to DNA damage.
“Metabolic syndrome” is characterized by a group of metabolic risk factors including: abdominal obesity (excessive fat tissue in and around the abdomen), atherogenic dyslipidemia (blood fat disorders (including high triglycerides, low HDL cholesterol and high LDL cholesterol) that foster plaque build-up in artery walls), elevated blood pressure, insulin resistance or glucose intolerance (due to the body's inability to properly use insulin or blood sugar), a prothrombotic state (e.g., high fibrinogen or plasminogen activator inhibitor-1 in the blood), and a proinflammatory state (e.g., elevated C-reactive protein in the blood). People with metabolic syndrome are at increased risk of coronary heart disease and other diseases related to plaque buildups in artery walls (e.g., stroke and peripheral vascular disease), and Type II diabetes. Other metabolic diseases suitable for treatment with a dsRNA targeting GSK-3 include obesity and insulin resistance.
A dsRNA targeting GSK-3 can be also be useful for the treatment of cancer, such as a colorectal cancer.
A composition containing a dsRNA targeting GSK-3 may also be used to treat other tumors and cancers, such as breast cancer, lung cancer, head and neck cancer, brain cancer, abdominal cancer, colon cancer, colorectal cancer, esophagus cancer, gastrointestinal cancer, glioma, tongue cancer, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, retinoblastoma, Wilm's tumor, multiple myeloma and for the treatment of skin cancer, like melanoma, for the treatment of lymphomas and blood cancer.
Owing to the inhibitory effects on GSK-3 expression, a composition according to the invention or a pharmaceutical composition prepared therefrom can enhance the quality of life.
The invention further relates to the use of a dsRNA or a pharmaceutical composition thereof, e.g., for treating manic depression or another disorder described herein, in combination with other pharmaceuticals and/or other therapeutic methods, e.g., with known pharmaceuticals and/or known therapeutic methods, such as, for example, those which are currently employed for treating these disorders.
For example, in the treatment of manic depression, the patient can also be treated with one or more other therapeutic modalities, e.g., lithium salts, anticonvulsant mood stabilizers, antipsychotics, and other adjunctive treatments described herein. In an embodiment the patient is also treated with lithium salts. Lithium salts have been used as a first-line treatment for bipolar disorder. Common lithium salts are lithium carbonate and (probably less commonly) lithium citrate. Lithium orotate is used as an alternative treatment to lithium carbonate by some individuals with bipolar disorder. In an embodiment the patient is also treated with an anticonvulsant mood stabilizer. Anticonvulsant medications, particularly valproate and carbamazepine, have been used as alternatives or adjuncts to lithium in many cases. Valproate (Depakote, Epival) was FDA approved for the treatment of acute mania in 1995, and is now considered by some doctors to be the first line of therapy for bipolar disorder. A similar medication, valproic acid (Depakene) is also used. Anticonvulsants are also used in combination with antipsychotics. Newer anticonvulsant medications, including lamotrigine and oxcarbazepine, are also effective as mood stabilizers in bipolar disorder. Lamotrigine is particularly promising, as it alleviates bipolar depression and prevents recurrence at higher rates. Zonisamide (trade name Zonegran), another anticonvulsant, also may show promise in treating bipolar depression. Topiramate maybe useful for some patients. It appears to be useful in some treatment resistant cases and for anxiety issues when clonazepam cannot be prescribed. Other anticonvulsants effective in some cases and under study include phenytoin, levetiracetam, pregabalin and valnoctamide. In an embodiment the patient is also treated with an “atypical antipsychotic drug.” The newer atypical antipsychotic drugs such as risperidone, quetiapine, and olanzapine are often used in acutely manic patients. In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder. Eli Lilly and Company also offers Symbyax, a combination of olanzapine and fluoxetine. Ziprasidone (Geodon) and aripriprazole (Abilify) also show promise. Other newer treatments include Modafinil (Provigil) and Pramipexole (Mirapex), which show promise in treating the cognitive deterioration related to bipolar depression. In addition Riluzole, an ALS treatment, has been shown to be effective treatment. The breast cancer medicine tamoxifen has shown quick response to manic phases. In an embodiment the patient is also treated with electroconvulsive therapy. Electroconvulsive therapy (ECT) is sometimes used to treat severe bipolar depression in cases where other treatments have failed and is 60 to 70 percent effective.
In an embodiment the patient is also treated with psychotherapy. Other treatments include omega-3 fatty acids, particularly as a supplement to other medication. There are also reports that medical marijuana can help control the mood swings in some forms of bipolar disorder.
In an embodiment a dsRNA described herein is administered to a patient who has previously been treated with another therapeutic or counseling modality but which has provided less than optimal results.
In the example of a metabolic disorder, e.g., diabetes, the patient can also be provided administration of a dsRNA targeting GSK-3 can be accompanied by a exercise regimen or by dietary restrictions. A dsRNA featured in the invention can also be administered with a drug or combination of drugs for managing Type II diabetes, e.g., a sulfonylurea, a biguanide, an alpha-glucosidase inhibitor, a thiazolidinedione, a meglitinide, a D-phenylalanine derivative, an amylin synthetic derivatives, an incretin mimetic, or an insulin. Exemplary insulins include regular insulins (Humulin®, Novolin®), insulin lispro (Humalog®), insulin aspart (Novolog®), insulin glulisine (Apidra®), prompt insulin zinc (Semilente®, slightly slower acting), inhaled insulin (Exubera®), intermediate-acting insulins, isophane insulin, neutral protamine Hagedorn (NPH), insulin zinc (Lente®), extended insulin zinc insulin (Ultralente®), insulin glargine (Lantus®), and insulin detemir (Levemir®).
In the example of cancer the patient can also be provided with a chemotherapy agent, such as deoxycoformycin, cisplatin, cyclophosphamide, 5-fluorouracil, adriamycin, daunorubicin, tamoxifen aunorubicin, daunomycin, dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide, ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D, mithramycin, prednisone, hydroxyprogesterone, testosterone, tamoxifen, dacarbazine, procarbazine, hexamethylmelamine, pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea, nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea, deoxycoformycin, 4-hydroxyperoxycyclophosphoramide, 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine, taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate, irinotecan, topotecan, gemcitabine, teniposide, cisplatin and diethylstilbestrol (DES). See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228, Berkow et al., eds., Rahway, N.J. When used with the dsRNAs featured in the invention, such chemotherapeutic agents may be used individually (e.g., deoxycoformycin and dsRNA), sequentially (e.g., antiviral and dsRNA for a period of time, followed by deoxycoformycin and dsRNA), or in combination with one or more other such agents (e.g., deoxycoformycin, antiviral and dsRNA, or deoxycoformycin, radiotherapy and dsRNA). Two or more combined compounds may be used together or sequentially.
Generally, the dsRNAs described here can be used in combination with other GSK-3 inhibitors. Examples of such inhibitors described in Meijer et al., Trends in Pharmacological Sciences, 25: 471 (September 2004), incorporated herein by reference include pyrroloazepines, (e.g., hymenialdisine), flavones (e.g., flavopiridol), benzazepinones (e.g., kenpaullone, alsterpaulione, and azakenpaullone), bis-indole indirubin-3′-oximes (e.g., indirubin-3′-oxime, 6-bromoindirubin-3′-oxime (BIO), and 6-bromoindirubin-3′-acetoxime), pyrrolopyrazines (e.g., aloisine A and aloisine B), thiadiazolidinones (e.g., TDZD8), pyridyloxadiazoles (e.g., Compound 12), pyrazolopyridines (e.g., pyrazolopyridine 18 and pyrazolopyridine 34), pyrazolopyridazines (e.g., pyrazolopyridine 9), aminopyrimidines (e.g., CHIR98014 and CHIR99021 (CT99021)), pyrazoloquinoxalines (Compound 1), oxindoles (indolinones) (e.g., SU9516), thiazoles (e.g., ARA014418), bisindolylmaleimides (e.g., staurosporine and Compound 5a), azaindolylmaleimides (e.g., Compound 29 and Compound 46), bisindolylmaleimides (e.g., GF109203x (bisindolylmaleimide I) and Ro318220 (bisindolylmaleimide IX)), arylindolemaleimides (e.g., SB216763), anilinomaleimides (e.g., SB415286), anilinoarylmaleimides (e.g., IS), phenylaminopyrimidines (e.g., CGP60474), triazoles (e.g., Compound 8b), pyrrolopyrimidines (e.g., TWS119), pyrazolopyrimidines (e.g., Compound 1A), chloromethyl thienyl ketone (e.g., Compound 17), atoms in competition with Mg²⁺ (e.g., lithium), atoms in competition with Mg²⁺ and ATP (e.g., beryllium), and uncompetitive atoms (e.g., zinc). Structures for some of the inhibitors can be found in FIG. 2 of Meijer et al. and are shown below.
Methods for Inhibiting Expression of the GSK-3 Gene
In yet another aspect, the invention provides a method for inhibiting the expression of an GSK-3 gene in a mammal. The method includes administering a composition featured in the invention to the mammal such that expression of the target GSK-3 gene is silenced.
When the organism to be treated is a mammal such as a human, the composition may be administered by any means known in the art including, but not limited to oral or parenteral routes, including intravenous, intramuscular, subcutaneous, transdermal, airway (aerosol), nasal, rectal, and topical (including buccal and sublingual) administration. In preferred embodiments, the compositions are administered by intravenous infusion or injection.
Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.

EXAMPLE

Example 1

Design and Synthesis of siRNA Targeting GSK3

siRNA Design for Mouse Glycogen Synthase Kinase 3 Alpha (GSK3α)
All possible perfect match sense 19mer oligomers were extracted from mouse GSKalpha sequence NM_—001031667.1, the sole NCBI reference sequence for the mouse GSK3α gene, and identified as candidate target regions. The sequences are shown in Table 1 below.
In order to rank candidate target sequences and their corresponding siRNAs and select appropriate ones, their predicted potential for interacting with irrelevant targets (off-target potential) was taken as the primary ranking parameter. siRNAs with low off-target potential were defined as preferable and assumed to be more specific in vivo.
To identify potential off-target genes, 19mer candidate sequences as well as their 19mer reverse complements were subjected to a homology search against the entire NCBI mouse reference mRNA sequence collection using the FASTA search algorithm (Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence Comparison. PNAS (1988) 85: 2444-8.).
The following off-target properties for every 19mer were extracted for each oligo-mouse transcript alignment to calculate the off-target score:

- 1. Number of mismatches in seed region, defined as positions 2-9 of the oligomer
- 2. Number of mismatches in cleavage site region, defined as positions 10 and 11
- 3. Number of mismatches in non-seed region, non-cleavage region, defined as positions 12-19
- 4. Mismatches in position 1 were ignored

The off-target score for each oligo-transcript pair was calculated for considering assumptions 1 to 3 as follows:
Off-target score=(number of seed mismatches*2.8)+(number of cleavage site mismatches*1.2)+(number of non-seed mismatches*1)
The most relevant off-target gene for each siRNA corresponding to the input 19mer sequence was defined as the gene with the lowest off-target score. The candidate oligomers were ranked first by the lowest off-target score for the antisense sequence, and secondarily by the lowest off-target score by its sense counterpart. The top 11 oligo sense and antisense pairs from the list were synthesized and their capacity for knockdown of the mouse GSK3α transcript measured. The sequences are shown in Table 4.
Sense and antisense oligomers complementary to the human GSK3α gene (NM_—002093) were designed by first aligning the orthologous transcripts, and then identifying the human counterpart region of the mouse candidate target regions. The sequences are shown in Table 6.
siRNA Design for Mouse Glycogen Synthase Kinase 3 Beta (GSK3β)
All possible perfect match sense 19mer oligomers were extracted from NM_—019827.4 the sole NCBI reference sequence for the mouse Gsk3β gene, and identified as candidate target regions. The sequences are shown in Table 2.
In order to rank candidate target sequences and their corresponding siRNAs and select appropriate ones, their predicted potential for interacting with irrelevant targets (off-target potential) was taken as the primary ranking parameter. siRNAs with low off-target potential were defined as preferable and assumed to be more specific in vivo.
To identify potential off-target genes, 19mer candidate sequences as well as their 19mer reverse complements were subjected to a homology search against the entire NCBI mouse reference mRNA sequence collection using the FASTA search algorithm (Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence Comparison. PNAS (1988) 85: 2444-8).
The following off-target properties for every 19mer were extracted for each oligo-mouse transcript alignment to calculate the off-target score:

The off-target score for each oligo-transcript pair was calculated for considering assumptions 1 to 3 as follows:
Off-target score=(number of seed mismatches*2.8)+(number of cleavage site mismatches*1.2)+(number of non-seed mismatches*1)
The most relevant off-target gene for each siRNA corresponding to the input 19mer sequence was defined as the gene with the lowest off-target score. The candidate oligomers were ranked first by the lowest off-target score for the antisense sequence, and secondarily by the lowest off-target score by its sense counterpart. The top 11 oligo sense and antisense pairs from the list were synthesized and their capacity for knockdown of the mouse Gsk3β transcript measured. The sequences are shown in Table 5.
Sense and antisense oligomers complementary to the human GSK3β gene (NM_—019884.2) were designed by first aligning the orthologous transcripts, and then identifying the human counterpart region of the mouse candidate target regions. The sequences are shown in Table 7.
Table 3 provides a description of the abbreviations used herein.

TABLE 3

Abbreviations of nucleotide monomers used in nucleic
acid sequence representation. It will be understood that
these monomers, when present in an oligonucleotide, are
mutually linked by 5′-3′-phosphodiester bonds.

Abbreviation^a	Nucleotide(s)

A	adenosine-5′-phosphate
C	cytidine-5′-phosphate
G	guanosine-5′-phosphate
T, dT	2′-deoxy-thymidine-5′-phosphate
U	uridine-5′-phosphate
N	any nucleotide (G, A, C, or T)
a	2′-O-methyladenosine-5′-phosphate
c	2′-O-methylcytidine-5′-phosphate
g	2′-O-methylguanosine-5′-phosphate
u	2′-O-methyluridine-5′-phosphate
sT, sdT	2′-deoxy-thymidine-5′phosphate-phosphorothioate

Source of Reagents
Where the source of a reagent is not specifically given herein, such reagent may be obtained from any supplier of reagents for molecular biology at a quality/purity standard for application in molecular biology.
siRNA Synthesis
Single-stranded RNAs can be produced by solid phase synthesis on a scale of 1 μmole using an Expedite 8909 synthesizer (Applied Biosystems, Applera Deutschland GmbH, Darmstadt, Germany) and controlled pore glass (CPG, 500 Å, Proligo Biochemie GmbH, Hamburg, Germany) as solid support. RNA and RNA containing 2′-O-methyl nucleotides can be generated by solid phase synthesis employing the corresponding phosphoramidites and 2′-O-methyl phosphoramidites, respectively (Proligo Biochemie GmbH, Hamburg, Germany). These building blocks can be incorporated at selected sites within the sequence of the oligoribonucleotide chain using standard nucleoside phosphoramidite chemistry such as described in Current protocols in nucleic acid chemistry, Beaucage, S. L. et al. (Edrs.), John Wiley & Sons, Inc., New York, N.Y., USA. Phosphorothioate linkages can be introduced by replacement of the iodine oxidizer solution with a solution of the Beaucage reagent (Chruachem Ltd, Glasgow, UK) in acetonitrile (1%). Further ancillary reagents can be obtained from Mallinckrodt Baker (Griesheim, Germany).
Deprotection and purification of the crude oligoribonucleotides by anion exchange HPLC can be carried out according to established procedures. Yields and concentrations can be determined by UV absorption of a solution of the respective RNA at a wavelength of 260 nm using a spectral photometer (DU 640B, Beckman Coulter GmbH, Unterschleiβheim, Germany). Double stranded RNA can be generated by mixing an equimolar solution of complementary strands in annealing buffer (20 mM sodium phosphate, pH 6.8; 100 mM sodium chloride), heated in a water bath at 85-90° C. for 3 minutes and cooled to room temperature over a period of 3-4 hours. The annealed RNA solution can be stored at −20° C. until use.
For the synthesis of 3′-cholesterol-conjugated siRNAs (herein referred to as -Chol-3′), an appropriately modified solid support can be used for RNA synthesis. The modified solid support was prepared as follows:

Diethyl-2-azabutane-1,4-dicarboxylate AA

A 4.7 M aqueous solution of sodium hydroxide (50 mL) can be added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) can be added and the mixture can be stirred at room temperature until completion of the reaction can be ascertained by TLC. After 19 h the solution can be partitioned with dichloromethane (3×100 mL). The organic layer can be dried with anhydrous sodium sulfate, filtered and evaporated. The residue can be distilled to afford AA (28.8 g, 61%).

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonyl-amino)-hexanoyl]-amino}-propionic acid ethyl ester AB

Fmoc-6-amino-hexanoic acid (9.12 g, 25.83 mmol) can be dissolved in dichloromethane (50 mL) and cooled with ice. Diisopropylcarbodiimde (3.25 g, 3.99 mL, 25.83 mmol) can be added to the solution at 0° C. It can then be followed by the addition of Diethyl-azabutane-1,4-dicarboxylate (5 g, 24.6 mmol) and dimethylamino pyridine (0.305 g, 2.5 mmol). The solution can be brought to room temperature and stirred further for 6 h. Completion of the reaction was ascertained by TLC. The reaction mixture can be concentrated under vacuum and ethyl acetate can be added to precipitate diisopropyl urea. The suspension can be filtered. The filtrate can be washed with 5% aqueous hydrochloric acid, 5% sodium bicarbonate and water. The combined organic layer can be dried over sodium sulfate and concentrated to give the crude product which can be purified by column chromatography (50% EtOAC/Hexanes) to yield 11.87 g (88%) of AB.

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester AC

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) can be dissolved in 20% piperidine in dimethylformamide at 0° C. The solution can be stirred continuously for 1 h. The reaction mixture can be concentrated under vacuum, water can be added to the residue, and the product can be extracted with ethyl acetate. The crude product can be purified by conversion into its hydrochloride salt.

3-({6-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoyl}ethoxycarbonylmethyl-amino)-propionic acid ethyl ester AD

The hydrochloride salt of 3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester AC (4.7 g, 14.8 mmol) can be taken up in dichloromethane. The suspension was cooled to 0° C. on ice. To the suspension diisopropylethylamine (3.87 g, 5.2 mL, 30 mmol) can be added. To the resulting solution cholesteryl chloroformate (6.675 g, 14.8 mmol) can be added. The reaction mixture can be stirred overnight. The reaction mixture can be diluted with dichloromethane and washed with 10% hydrochloric acid. The product can be purified by flash chromatography (10.3 g, 92%).

1-{6-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoy}-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester AE

Potassium t-butoxide (1.1 g, 9.8 mmol) can be slurried in 30 mL of dry toluene. The mixture can be cooled to 0° C. on ice and 5 g (6.6 mmol) of diester AD can be added slowly with stirring within 20 mins. The temperature can be kept below 5° C. during the addition. The stirring can be continued for 30 mins at 0° C. and 1 mL of glacial acetic acid can be added, immediately followed by 4 g of NaH₂PO₄.H₂O in 40 mL of water. The resultant mixture can be extracted twice with 100 mL of dichloromethane each and the combined organic extracts can be washed twice with 10 mL of phosphate buffer each, dried, and evaporated to dryness. The residue can be dissolved in 60 mL of toluene, cooled to 0° C. and extracted with three 50 mL portions of cold pH 9.5 carbonate buffer. The aqueous extracts can be adjusted to pH 3 with phosphoric acid, and extracted with five 40 mL portions of chloroform which can be combined, dried and evaporated to dryness. The residue can be purified by column chromatography using 25% ethylacetate/hexane to afford 1.9 g of b-ketoester (39%).

[6-(3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-yl)-6-oxo-hexyl]-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AF

Methanol (2 mL) can be added dropwise over a period of 1 h to a refluxing mixture of b-ketoester AE (1.5 g, 2.2 mmol) and sodium borohydride (0.226 g, 6 mmol) in tetrahydrofuran (10 mL). Stirring can be continued at reflux temperature for 1 h. After cooling to room temperature, 1 N HCl (12.5 mL) can be added, the mixture was extracted with ethylacetate (3×40 mL). The combined ethylacetate layer can be dried over anhydrous sodium sulfate and concentrated under vacuum to yield the product which can be purified by column chromatography (10% MeOH/CHCl₃) (89%).

(6-{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-6-oxo-hexyl)-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AG

Diol AF (1.25 gm 1.994 mmol) can be dried by evaporating with pyridine (2×5 mL) in vacuo. Anhydrous pyridine (10 mL) and 4,4′-dimethoxytritylchloride (0.724 g, 2.13 mmol) can be added with stirring. The reaction can be carried out at room temperature overnight. The reaction can be quenched by the addition of methanol. The reaction mixture can be concentrated under vacuum and to the residue dichloromethane (50 mL) was added. The organic layer can be washed with 1M aqueous sodium bicarbonate. The organic layer can be dried over anhydrous sodium sulfate, filtered and concentrated. The residual pyridine can be removed by evaporating with toluene. The crude product can be purified by column chromatography (2% MeOH/Chloroform, Rf=0.5 in 5% MeOH/CHCl₃) (1.75 g, 95%).

Succinic acid mono-(4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-{6-[17-(1,5-dimethyl-hexyl)-10,13-dimethyl 2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoy}1-pyrrolidin-3-yl) ester AH

Compound AG (1.0 g, 1.05 mmol) can be mixed with succinic anhydride (0.150 g, 1.5 mmol) and DMAP (0.073 g, 0.6 mmol) and dried in a vacuum at 40° C. overnight. The mixture can be dissolved in anhydrous dichloroethane (3 mL), triethylamine (0.318 g, 0.440 mL, 3.15 mmol) can be added and the solution can be stirred at room temperature under argon atmosphere for 16 h. It can then be diluted with dichloromethane (40 mL) and washed with ice cold aqueous citric acid (5 wt %, 30 mL) and water (2×20 mL). The organic phase can be dried over anhydrous sodium sulfate and concentrated to dryness. The residue can be used as such for the next step.
Cholesterol Derivatised CPG AI
Succinate AH (0.254 g, 0.242 mmol) can be dissolved in a mixture of dichloromethane/acetonitrile (3:2, 3 mL). To that solution DMAP (0.0296 g, 0.242 mmol) in acetonitrile (1.25 mL), 2,2′-Dithio-bis(5-nitropyridine) (0.075 g, 0.242 mmol) in acetonitrile/dichloroethane (3:1, 1.25 mL) can be added successively. To the resulting solution triphenylphosphine (0.064 g, 0.242 mmol) in acetonitrile (0.6 ml) was added. The reaction mixture can turn bright orange in color. The solution can be agitated briefly using a wrist-action shaker (5 mins). Long chain alkyl amine-CPG (LCAA-CPG) (1.5 g, 61 mM) can be added. The suspension can be agitated for 2 h. The CPG was filtered through a sintered funnel and washed with acetonitrile, dichloromethane and ether successively. Unreacted amino groups can be masked using acetic anhydride/pyridine. The achieved loading of the CPG can be measured by taking UV measurement (37 mM/g).
The synthesis of siRNAs bearing a 5′-12-dodecanoic acid bisdecylamide group (herein referred to as “5′-C32-”) or a 5′-cholesteryl derivative group (herein referred to as “5′-Chol-”) can be performed as described in WO 2004/065601, except that, for the cholesteryl derivative, the oxidation step can be performed using the Beaucage reagent in order to introduce a phosphorothioate linkage at the 5′-end of the nucleic acid oligomer.

Example 2

In Vitro Screen of GSK3α and GSK3β siRNAs Against Endogenous GSK3α and GSK3β mRNA Expression in Mouse HT22 Cells

Mouse HT22 cells were a gift from Dr. Marcy MacDonald and cultured in Dulbecco's modified Eagle's medium supplied with 10% fetal bovine serum and differentiated in modified serum-free medium (Dulbecco's modified Eagle's medium, N2 supplement, 50 ng/ml nerve growth factor-β, 100 μM phorbol 12,13-dibutyrate, 100 μM dibutyryl cAMP) for 24-48 h before treatment. All treatments were performed in differentiation medium with reduced nerve growth factor-13 content (5 ng/ml) at 37° C. in a humidified incubator with 5% CO₂.
Cells were transfected with the modified siRNAtargeting mouse GSK3α or GSK3β described in Table 4 and Table 5. For transfection with siRNA, HT22 cells were seeded at a density of 1.0×10⁵cells/well in 6-well tissue culture plates and transfected directly. Transfection of siRNA (37.5 nM for single dose screen) was carried out with Lipofectamine2000 (Invitrogen, Carlsbad, Calif.) as described by the manufacturer. For dose-response curves, siRNA concentrations ranged from 10 nM to 0.1 nM in 10-fold dilutions.
24 hours after transfection, HT22 cells were lysed and cDNA was generated for GSK3α or GSK3β and GAPDH mRNA quantitation. GSK3α or GSK3β mRNA levels were normalized to GAPDH mRNA levels. For each siRNA, 2 individual data points were collected. An siRNA duplex unrelated to the GSK3α or GSK3β gene was used as a control. The activity of a given GSK3α- or GSK3β-specific siRNA duplex was expressed as the fraction of the GSK3α or GSK3β mRNA level in treated cells relative to the GSK3α or GSK3β mRNA level in cells treated with the control siRNA duplex.
Duplex Identifier Used in the Figures and in Examples 2-5 Refer to the Modified Version of the Duplex, e.g., AD-18821 as Used in the Figures and Examples 2-5 Refers to the Modified Version of AD-18821, e.g., AD-18821-B1.
FIG. 1 and FIG. 2 provide the results from the in vitro HT22 screen where the siRNAs were tested at a single dose of 37.5 nM. The fraction of GSK3α and GSK3β mRNA remaining in treated cells compared to controls, ±standard deviation, is shown. A number of GSK3α siRNAs (AD-18821, AD-18825 or AD-18832) at 37.5 nM were effective at reducing GSK3α mRNA levels by more than 40%, without affecting GSK3β mRNA levels, in HT22 cells. A number of GSK3β siRNAs (AD-18833, AD-18834, AD-18836, AD-18837, AD-18838, AD-18841, AD-18842, AD-18843 or AD-18844) at 37.5 nM were effective at reducing GSK3 β mRNA levels by more than 40%, without affecting GSK3α mRNA levels, in HT22 cells.
FIG. 3 and FIG. 4 show the dose-dependence of selected siRNAs on mRNA reduction in HT22 cells. Several siRNAs targeting GSK3α (AD-18821, AD-18825 or AD-18826) exhibited IC50 values of less than or equal to 1-10 nM in suppressing GSK3α mRNA after transfection into HT22 cells (FIG. 3). Several siRNAs targeting GSK3β (AD-18838 or AD-18843) exhibited IC50 values of less than 1 nM in suppressing GSK3β mRNA (FIG. 4).

Example 3

GSK3β dsRNAs Reduce Endogenous GSK3β Protein in HT22 Cells

HT22 cells were cultured and transfected as previously described with 75 nM of 11 siRNAs against GSK3β (AD-18833, AD-18834, AD-18835, AD-18836, AD-18837, AD-18838, AD-18839, AD-18841, AD-18842, AD-18843 or AD-18844); one control unrelated siRNA (AD-1955) or Lipofectamine2000 alone (Control). 48 hours post-transfection, the cells were harvested and lysed. Proteins in the lysates were separated on a denaturing polyacrylamide gel. GSK3β and β-actin were detected by standard western blot protocols using antibodies that bind to the proteins. For GSK3β detection, the membrane was probed with a monoclonal GSK3β antibody produced in rabbit (Cell Signaling, Danvers, Mass.) followed by a secondary antibody donkey anti-rabbit IgG horseradish peroxidase (GE Healthcare, Piscataway, N.J.). β-actin was detected by mouse anti-actin antibody (Sigma, St. Louis, Mo.) followed by a Sheep anti-mouse IgG horseradish peroxidase secondary antibody (GE Healthcare, Piscataway, N.J.).
FIG. 5 provides the results. AD-18838, AD-18843 and AD-18844, all at 75 nM, decreased the level of GSK3β protein relative to the control protein β-actin, whereas the control unrelated siRNA had no effect on the level of GSK3β protein. These results demonstrate that dsRNAs targeting GSK3β effectively reduce not only GSK3β mRNA levels, but also GSK3β protein levels.

Example 4

In Vivo Down-Modulation of Endogenous GSK3α or GSK3β mRNA Levels by CNS Administration of GSK3α or GSK3β dsRNAs in Mice

To assess the biological activity of GSK3 dsRNAs in vivo, dsRNAs targeting GSK3α (AD-18821, AD-18825, and AD-18826) or GSK3β (AD-18838, AD-18843, and AD-18844) were evaluated.
In mice, 1.26 mg AD-18821, AD-18825, AD-18826, AD-18838, AD-18843, AD-18844, or phosphate-buffered saline (PBS, vehicle control) was administered by continuous infusion into the nucleus accumbens over 14 days. Ten week old male C57BL6 mice (Charles River Laboratory) received stereotaxic implantations of 30-gauge infusion cannulae (Plastics One, Roanok, Va.) such that unilateral infusions were targeted to the nucleus accumbens (anteroposterior+1.1 mm, mediolateral+1.3 mm, relative to bregma; dorsoventral 4.5 mm, relative to skull surface). Mini-osmotic pumps (model 1002) were primed overnight according to the manufacturer's specifications, implanted subcutaneously, and connected via catheters, to deliver (6 mice per treatment group) PBS, 1.1 mM (15 mg/mL) of GSK3α siRNAs (AD-18821, AD-18825, or AD-18826) or 1.1 mM (15 mg/mL) of GSK3β siRNAs (AD-18838, AD-18843, or AD-18844) at 0.25 μL/hr over 14 days. At the end of the 14 day infusion period, animals were sacrificed, brains were removed, and 1.2 mm punches from the ipsilateral nucleus accumbens encompassing the infusion site, from 1 mm thick coronal brain slabs, were flash frozen and stored at −80° C. Individual brain punches from each mouse were quantified for GSK3α and GSK3β mRNA. Each brain punch was run in triplicate for RT-qPCR. Approximately 60 ng of total RNA in a 20 μl total reaction volume was used for RT-qPCR. GSK3α and GSK3β primers were custom designed and obtained from IDT (Integrated DNA Technologies, Inc., Coralville, Iowa). RT-qPCR was run with SBYR. GAPDH was used as the internal control for normalization. Relative expression of GSK3α and GSK3β mRNA was quantified by 2^ΔCt(where ΔCt=Ct_gene−Ct_GAPDH).
The GSK3β siRNAs, AD-18844, AD-18838 or AD-18843, showed 53% (ANOVA; p=0.012) (FIG. 6), 28% or 25% GSK3β mRNA reduction in the ipsilateral nucleus accumbens, respectively, compared to PBS control. The GSK3β siRNA, AD-18844, had no effect on GSK3α mRNA levels. The GSK3α siRNAs, AD-18826, AD-18825 or AD-18821, showed 51% (p=0.052; Tukey Post-hoc ANOVA) (FIG. 7), 42% (t-test; p=0.004) or 15% GSK3α mRNA reduction in the ipsilateral nucleus accumbens, respectively, compared to PBS control. The GSK3α siRNA, AD-18826, had no effect on GSK3β mRNA levels.
These results demonstrate that infusion into the nucleus accumbens of AD-18844 and AD-18826 are efficacious in vivo in specifically down-modulating GSK3β and GSK3α mRNA levels, respectively, in the nucleus accumbens.

Example 5

Inhibition of GSK-3 Expression in Human Cells

A set of siRNA targeting human GSK3α and GSK3β (Table 6 and Table 7) are evaluated for inhibition of GSK-3 expression in human cell lines. Human cell lines expressing endogenouseGSK3 are transfected with at least one of the duplexes in Table 6 or Table 7, e.g., huGSKA-3 (orthologous to AD-18826-b1) and/or huGSKB-11 (orthologous to AD-18826-b1). The human duplexes can be modified in a similar manner to the mouse duplexes. The transfected cells are assayed for effects on mRNA and protein levels using techniques described herein and known to one of skill in the art.

Example 6

Inhibition of GSK-3 Expression in Humans

A human subject is treated with a pharmaceutical composition comprising a pharmaceutical formulation of an siRNA targeting a human GSK-3 gene.
A subject in need of treatment is selected or identified. The subject can be in need of treatment for manic depression, a metabolic disease, a nervous system disorders, or cancer.
At time zero, a suitable first dose of the composition is subcutaneously administered to the subject. The composition is formulated as described herein. After a period of time, the subject's condition is evaluated, e.g., by measurement episodes of mania, episodes of depression, and the like. This measurement can be accompanied by a measurement of GSK-3 expression in said subject, and/or the products of the successful siRNA-targeting of GSK-3. Other relevant criteria can also be measured. The number and strength of doses are adjusted according to the subject's needs.
After treatment, the subject's condition is compared to the condition existing prior to the treatment, or relative to the condition of a similarly afflicted but untreated subject.

TABLE 1

Sequences of duplexes targeting Mouse GSK3-alpha
Sequences of possible duplexes targeting mouse GSK3-alpha. Target
sequence location identifies target sequence in mouse GSK3-alpha
mRNA NM_001031667.1. Unmodified sense strand is identical to target
sequence. Unmodified a antisense strand is complementary to target
sequence.

Target	SEQ	Unmodified	SEQ
sequence	ID	sequence	ID	Modified sequence
location	NO:	5′ to 3′	NO:	5′ to 3′	Strand

670-689	1	AACUGCAGAUUAUGCGUAA	2	AAcuGcAGAuuAuGcGuAAdTsdT	sense

670-689	3	UUACGCAUAAUCUGCAGUU	4	UuACGcAuAAUCUGcAGUUdTsdT	antis

1074-1093	5	ACAGAUUACACCUCGUCCA	6	AcAGAuuAcAccucGuccAdTsdT	sense

1074-1093	7	UGGACGAGGUGUAAUCUGU	8	UGGACGAGGUGuAAUCUGUdTsdT	antis

330-349	9	GGCGGCGGGAAAGCGUCAG	10	GGcGGcGGGAAAGcGucAGdTsdT	sense

330-349	11	CUGACGCUUUCCCGCCGCC	12	CUGACGCUUUCCCGCCGCCdTsdT	antis

239-258	13	GGCGCGGACCAGCUCGUUC	14	GGcGcGGAccAGcucGuucdTsdT	sense

239-258	15	GAACGAGCUGGUCCGCGCC	16	GAACGAGCUGGUCCGCGCCdTsdT	antis

1340-1359	17	CCUACUGGAGUACACGCCA	18	ccuAcuGGAGuAcAcGccAdTsdT	sense

1340-1359	19	UGGCGUGUACUCCAGUAGG	20	UGGCGUGuACUCcAGuAGGdTsdT	antis

1342-1361	21	UACUGGAGUACACGCCAUC	22	uAcuGGAGuAcAcGccAucdTsdT	sense

1342-1361	23	GAUGGCGUGUACUCCAGUA	24	GAUGGCGUGuACUCcAGuAdTsdT	antis

1073-1092	25	CACAGAUUACACCUCGUCC	26	cAcAGAuuAcAccucGuccdTsdT	sense

1073-1092	27	GGACGAGGUGUAAUCUGUG	28	GGACGAGGUGuAAUCUGUGdTsdT	antis

1236-1255	29	CCUAACUAUACGGAGUUCA	30	ccuAAcuAuAcGGAGuucAdTsdT	sense

1236-1255	31	UGAACUCCGUAUAGUUAGG	32	UGAACUCCGuAuAGUuAGGdTsdT	antis

435-454	33	GCGGGCACUAGCUUCCCGC	34	GcGGGcAcuAGcuucccGcdTsdT	sense

435-454	35	GCGGGAAGCUAGUGCCCGC	36	GCGGGAAGCuAGUGCCCGCdTsdT	antis

1231-1250	37	UGAACCCUAACUAUACGGA	38	uGAAcccuAAcuAuAcGGAdTsdT	sense

1231-1250	39	UCCGUAUAGUUAGGGUUCA	40	UCCGuAuAGUuAGGGUUcAdTsdT	antis

1234-1253	41	ACCCUAACUAUACGGAGUU	42	AcccuAAcuAuAcGGAGuudTsdT	sense

1234-1253	43	AACUCCGUAUAGUUAGGGU	44	AACUCCGuAuAGUuAGGGUdTsdT	antis

1235-1254	45	CCCUAACUAUACGGAGUUC	46	cccuAAcuAuAcGGAGuucdTsdT	sense

1235-1254	47	GAACUCCGUAUAGUUAGGG	48	GAACUCCGuAuAGUuAGGGdTsdT	antis

1233-1252	49	AACCCUAACUAUACGGAGU	50	AAcccuAAcuAuAcGGAGudTsdT	sense

1233-1252	51	ACUCCGUAUAGUUAGGGUU	52	ACUCCGuAuAGUuAGGGUUdTsdT	antis

2027-2046	53	GCCCCCUGGGUGUAAAUAG	54	GcccccuGGGuGuAAAuAGdTsdT	sense

2027-2046	55	CUAUUUACACCCAGGGGGC	56	CuAUUuAcACCcAGGGGGCdTsdT	antis

5-24	57	UGACAACGAAGCCGACGGC	58	uGAcAAcGAAGccGAcGGcdTsdT	sense

5-24	59	GCCGUCGGCUUCGUUGUCA	60	GCCGUCGGCUUCGUUGUcAdTsdT	antis

1071-1090	61	GCCACAGAUUACACCUCGU	62	GccAcAGAuuAcAccucGudTsdT	sense

1071-1090	63	ACGAGGUGUAAUCUGUGGC	64	ACGAGGUGuAAUCUGUGGCdTsdT	antis

2000-2019	65	AGCCCAUCUCUCGUCUUCC	66	AGcccAucucucGucuuccdTsdT	sense

2000-2019	67	GGAAGACGAGAGAUGGGCU	68	GGAAGACGAGAGAUGGGCUdTsdT	antis

4-23	69	GUGACAACGAAGCCGACGG	70	GuGAcAAcGAAGccGAcGGdTsdT	sense

4-23	71	CCGUCGGCUUCGUUGUCAC	72	CCGUCGGCUUCGUUGUcACdTsdT	antis

1085-1104	73	CUCGUCCAUCGAUGUGUGG	74	cucGuccAucGAuGuGuGGdTsdT	sense

1085-1104	75	CCACACAUCGAUGGACGAG	76	CcAcAcAUCGAUGGACGAGdTsdT	antis

2070-2089	77	AAACGUCAAUUCACACCAU	78	AAAcGucAAuucAcAccAudTsdT	sense

2070-2089	79	AUGGUGUGAAUUGACGUUU	80	AUGGUGUGAAUUGACGUUUdTsdT	antis

2072-2091	81	ACGUCAAUUCACACCAUUC	82	AcGucAAuucAcAccAuucdTsdT	sense

2072-2091	83	GAAUGGUGUGAAUUGACGU	84	GAAUGGUGUGAAUUGACGUdTsdT	antis

251-270	85	CUCGUUCGCGGAGCCAGGA	86	cucGuucGcGGAGccAGGAdTsdT	sense

251-270	87	UCCUGGCUCCGCGAACGAG	88	UCCUGGCUCCGCGAACGAGdTsdT	antis

241-260	89	CGCGGACCAGCUCGUUCGC	90	cGcGGAccAGcucGuucGcdTsdT	sense

241-260	91	GCGAACGAGCUGGUCCGCG	92	GCGAACGAGCUGGUCCGCGdTsdT	antis

581-600	93	CGGAGUAGUAUACCAGGCA	94	cGGAGuAGuAuAccAGGcAdTsdT	sense

581-600	95	UGCCUGGUAUACUACUCCG	96	UGCCUGGuAuACuACUCCGdTsdT	antis

1076-1095	97	AGAUUACACCUCGUCCAUC	98	AGAuuAcAccucGuccAucdTsdT	sense

1076-1095	99	GAUGGACGAGGUGUAAUCU	100	GAUGGACGAGGUGuAAUCUdTsdT	antis

2069-2088	101	AAAACGUCAAUUCACACCA	102	AAAAcGucAAuucAcAccAdTsdT	sense

2069-2088	103	UGGUGUGAAUUGACGUUUU	104	UGGUGUGAAUUGACGUUUUdTsdT	antis

6-25	105	GACAACGAAGCCGACGGCA	106	GAcAAcGAAGccGAcGGcAdTsdT	sense

6-25	107	UGCCGUCGGCUUCGUUGUC	108	UGCCGUCGGCUUCGUUGUCdTsdT	antis

16-35	109	CCGACGGCAGAGGGACUUC	110	ccGAcGGcAGAGGGAcuucdTsdT	sense

16-35	111	GAAGUCCCUCUGCCGUCGG	112	GAAGUCCCUCUGCCGUCGGdTsdT	antis

243-262	113	CGGACCAGCUCGUUCGCGG	114	cGGAccAGcucGuucGcGGdTsdT	sense

243-262	115	CCGCGAACGAGCUGGUCCG	116	CCGCGAACGAGCUGGUCCGdTsdT	antis

244-263	117	GGACCAGCUCGUUCGCGGA	118	GGAccAGcucGuucGcGGAdTsdT	sense

244-263	119	UCCGCGAACGAGCUGGUCC	120	UCCGCGAACGAGCUGGUCCdTsdT	antis

328-347	121	CUGGCGGCGGGAAAGCGUC	122	cuGGcGGcGGGAAAGcGucdTsdT	sense

328-347	123	GACGCUUUCCCGCCGCCAG	124	GACGCUUUCCCGCCGCcAGdTsdT	antis

331-350	125	GCGGCGGGAAAGCGUCAGU	126	GcGGcGGGAAAGcGucAGudTsdT	sense

331-350	127	ACUGACGCUUUCCCGCCGC	128	ACUGACGCUUUCCCGCCGCdTsdT	antis

340-359	129	AAGCGUCAGUCGGGGCUAU	130	AAGcGucAGucGGGGcuAudTsdT	sense

340-359	131	AUAGCCCCGACUGACGCUU	132	AuAGCCCCGACUGACGCUUdTsdT	antis

432-451	133	GGCGCGGGCACUAGCUUCC	134	GGcGcGGGcAcuAGcuuccdTsdT	sense

432-451	135	GGAAGCUAGUGCCCGCGCC	136	GGAAGCuAGUGCCCGCGCCdTsdT	antis

655-674	137	GGUUCAAGAACCGAGAACU	138	GGuucAAGAAccGAGAAcudTsdT	sense

655-674	139	AGUUCUCGGUUCUUGAACC	140	AGUUCUCGGUUCUUGAACCdTsdT	antis

1024-1043	141	CCUACAUCUGCUCUCGGUA	142	ccuAcAucuGcucucGGuAdTsdT	sense

1024-1043	143	UACCGAGAGCAGAUGUAGG	144	uACCGAGAGcAGAUGuAGGdTsdT	antis

1075-1094	145	CAGAUUACACCUCGUCCAU	146	cAGAuuAcAccucGuccAudTsdT	sense

1075-1094	147	AUGGACGAGGUGUAAUCUG	148	AUGGACGAGGUGuAAUCUGdTsdT	antis

1089-1108	149	UCCAUCGAUGUGUGGUCGG	150	uccAucGAuGuGuGGucGGdTsdT	sense

1089-1108	151	CCGACCACACAUCGAUGGA	152	CCGACcAcAcAUCGAUGGAdTsdT	antis

1090-1109	153	CCAUCGAUGUGUGGUCGGC	154	ccAucGAuGuGuGGucGGcdTsdT	sense

1090-1109	155	GCCGACCACACAUCGAUGG	156	GCCGACcAcAcAUCGAUGGdTsdT	antis

1092-1111	157	AUCGAUGUGUGGUCGGCUG	158	AucGAuGuGuGGucGGcuGdTsdT	sense

1092-1111	159	CAGCCGACCACACAUCGAU	160	cAGCCGACcAcAcAUCGAUdTsdT	antis

1093-1112	161	UCGAUGUGUGGUCGGCUGG	162	ucGAuGuGuGGucGGcuGGdTsdT	sense

1093-1112	163	CCAGCCGACCACACAUCGA	164	CcAGCCGACcAcAcAUCGAdTsdT	antis

1230-1249	165	AUGAACCCUAACUAUACGG	166	AuGAAcccuAAcuAuAcGGdTsdT	sense

1230-1249	167	CCGUAUAGUUAGGGUUCAU	168	CCGuAuAGUuAGGGUUcAUdTsdT	antis

1348-1367	169	AGUACACGCCAUCCUCAAG	170	AGuAcAcGccAuccucAAGdTsdT	sense

1348-1367	171	CUUGAGGAUGGCGUGUACU	172	CUUGAGGAUGGCGUGuACUdTsdT	antis

1401-1420	173	UUCGAUGAACUGCGGAGAC	174	uucGAuGAAcuGcGGAGAcdTsdT	sense

1401-1420	175	GUCUCCGCAGUUCAUCGAA	176	GUCUCCGcAGUUcAUCGAAdTsdT	antis

1402-1421	177	UCGAUGAACUGCGGAGACU	178	ucGAuGAAcuGcGGAGAcudTsdT	sense

1402-1421	179	AGUCUCCGCAGUUCAUCGA	180	AGUCUCCGcAGUUcAUCGAdTsdT	antis

1489-1508	181	UCCAACCAUCUCUCAAUGC	182	uccAAccAucucucAAuGcdTsdT	sense

1489-1508	183	GCAUUGAGAGAUGGUUGGA	184	GcAUUGAGAGAUGGUUGGAdTsdT	antis

1999-2018	185	CAGCCCAUCUCUCGUCUUC	186	cAGcccAucucucGucuucdTsdT	sense

1999-2018	187	GAAGACGAGAGAUGGGCUG	188	GAAGACGAGAGAUGGGCUGdTsdT	antis

2028-2047	189	CCCCCUGGGUGUAAAUAGA	190	cccccuGGGuGuAAAuAGAdTsdT	sense

2028-2047	191	UCUAUUUACACCCAGGGGG	192	UCuAUUuAcACCcAGGGGGdTsdT	antis

2068-2087	193	GAAAACGUCAAUUCACACC	194	GAAAAcGucAAuucAcAccdTsdT	sense

2068-2087	195	GGUGUGAAUUGACGUUUUC	196	GGUGUGAAUUGACGUUUUCdTsdT	antis

2080-2099	197	UCACACCAUUCAACUUGCC	198	ucAcAccAuucAAcuuGccdTsdT	sense

2080-2099	199	GGCAAGUUGAAUGGUGUGA	200	GGcAAGUUGAAUGGUGUGAdTsdT	antis

2083-2102	201	CACCAUUCAACUUGCCCCC	202	cAccAuucAAcuuGcccccdTsdT	sense

2083-2102	203	GGGGGCAAGUUGAAUGGUG	204	GGGGGcAAGUUGAAUGGUGdTsdT	antis

2084-2103	205	ACCAUUCAACUUGCCCCCC	206	AccAuucAAcuuGccccccdTsdT	sense

2084-2103	207	GGGGGGCAAGUUGAAUGGU	208	GGGGGGcAAGUUGAAUGGUdTsdT	antis

2086-2105	209	CAUUCAACUUGCCCCCCCC	210	cAuucAAcuuGccccccccdTsdT	sense

2086-2105	211	GGGGGGGGCAAGUUGAAUG	212	GGGGGGGGcAAGUUGAAUGdTsdT	antis

2244-2263	213	UUGGCAUGAAACCCUUAAA	214	uuGGcAuGAAAcccuuAAAdTsdT	sense

2244-2263	215	UUUAAGGGUUUCAUGCCAA	216	UUuAAGGGUUUcAUGCcAAdTsdT	antis

71-90	217	AGCCGGAGCCCGAACGGCG	218	AGccGGAGcccGAAcGGcGdTsdT	sense

71-90	219	CGCCGUUCGGGCUCCGGCU	220	CGCCGUUCGGGCUCCGGCUdTsdT	antis

177-196	221	CCUGCGCUCGGCGCCAUGA	222	ccuGcGcucGGcGccAuGAdTsdT	sense

177-196	223	UCAUGGCGCCGAGCGCAGG	224	UcAUGGCGCCGAGCGcAGGdTsdT	antis

836-855	225	CACCCCUAUCAUCUACAUC	226	cAccccuAucAucuAcAucdTsdT	sense

836-855	227	GAUGUAGAUGAUAGGGGUG	228	GAUGuAGAUGAuAGGGGUGdTsdT	antis

929-948	229	GCCCCAGAAUUUGCUUGUG	230	GccccAGAAuuuGcuuGuGdTsdT	sense

929-948	231	CACAAGCAAAUUCUGGGGC	232	cAcAAGcAAAUUCUGGGGCdTsdT	antis

1001-1020	233	GGUUCGGGGGGAGCCCAAU	234	GGuucGGGGGGAGcccAAudTsdT	sense

1001-1020	235	AUUGGGCUCCCCCCGAACC	236	AUUGGGCUCCCCCCGAACCdTsdT	antis

1091-1110	237	CAUCGAUGUGUGGUCGGCU	238	cAucGAuGuGuGGucGGcudTsdT	sense

1091-1110	239	AGCCGACCACACAUCGAUG	240	AGCCGACcAcAcAUCGAUGdTsdT	antis

1328-1347	241	ACUCUGCUCUAGCCUACUG	242	AcucuGcucuAGccuAcuGdTsdT	sense

1328-1347	243	CAGUAGGCUAGAGCAGAGU	244	cAGuAGGCuAGAGcAGAGUdTsdT	antis

1338-1357	245	AGCCUACUGGAGUACACGC	246	AGccuAcuGGAGuAcAcGcdTsdT	sense

1338-1357	247	GCGUGUACUCCAGUAGGCU	248	GCGUGuACUCcAGuAGGCUdTsdT	antis

1339-1358	249	GCCUACUGGAGUACACGCC	250	GccuAcuGGAGuAcAcGccdTsdT	sense

1339-1358	251	GGCGUGUACUCCAGUAGGC	252	GGCGUGuACUCcAGuAGGCdTsdT	antis

2059-2078	253	UUUCUUAAAGAAAACGUCA	254	uuucuuAAAGAAAAcGucAdTsdT	sense

2059-2078	255	UGACGUUUUCUUUAAGAAA	256	UGACGUUUUCUUuAAGAAAdTsdT	antis

2067-2086	257	AGAAAACGUCAAUUCACAC	258	AGAAAAcGucAAuucAcAcdTsdT	sense

2067-2086	259	GUGUGAAUUGACGUUUUCU	260	GUGUGAAUUGACGUUUUCUdTsdT	antis

2076-2095	261	CAAUUCACACCAUUCAACU	262	cAAuucAcAccAuucAAcudTsdT	sense

2076-2095	263	AGUUGAAUGGUGUGAAUUG	264	AGUUGAAUGGUGUGAAUUGdTsdT	antis

2089-2108	265	UCAACUUGCCCCCCCCAGC	266	ucAAcuuGccccccccAGcdTsdT	sense

2089-2108	267	GCUGGGGGGGGCAAGUUGA	268	GCUGGGGGGGGcAAGUUGAdTsdT	antis

2231-2250	269	GUUCAAUAAAUUAUUGGCA	270	GuucAAuAAAuuAuuGGcAdTsdT	sense

2231-2250	271	UGCCAAUAAUUUAUUGAAC	272	UGCcAAuAAUUuAUUGAACdTsdT	antis

207-226	273	CCUUCGGGAGGCGGCCCUG	274	ccuucGGGAGGcGGcccuGdTsdT	sense

207-226	275	CAGGGCCGCCUCCCGAAGG	276	cAGGGCCGCCUCCCGAAGGdTsdT	antis

240-259	277	GCGCGGACCAGCUCGUUCG	278	GcGcGGAccAGcucGuucGdTsdT	sense

240-259	279	CGAACGAGCUGGUCCGCGC	280	CGAACGAGCUGGUCCGCGCdTsdT	antis

242-261	281	GCGGACCAGCUCGUUCGCG	282	GcGGAccAGcucGuucGcGdTsdT	sense

242-261	283	CGCGAACGAGCUGGUCCGC	284	CGCGAACGAGCUGGUCCGCdTsdT	antis

249-268	285	AGCUCGUUCGCGGAGCCAG	286	AGcucGuucGcGGAGccAGdTsdT	sense

249-268	287	CUGGCUCCGCGAACGAGCU	288	CUGGCUCCGCGAACGAGCUdTsdT	antis

252-271	289	UCGUUCGCGGAGCCAGGAG	290	ucGuucGcGGAGccAGGAGdTsdT	sense

252-271	291	CUCCUGGCUCCGCGAACGA	292	CUCCUGGCUCCGCGAACGAdTsdT	antis

324-343	293	GGCACUGGCGGCGGGAAAG	294	GGcAcuGGcGGcGGGAAAGdTsdT	sense

324-343	295	CUUUCCCGCCGCCAGUGCC	296	CUUUCCCGCCGCcAGUGCCdTsdT	antis

329-348	297	UGGCGGCGGGAAAGCGUCA	298	uGGcGGcGGGAAAGcGucAdTsdT	sense

329-348	299	UGACGCUUUCCCGCCGCCA	300	UGACGCUUUCCCGCCGCcAdTsdT	antis

427-446	301	GCCCCGGCGCGGGCACUAG	302	GccccGGcGcGGGcAcuAGdTsdT	sense

427-446	303	CUAGUGCCCGCGCCGGGGC	304	CuAGUGCCCGCGCCGGGGCdTsdT	antis

428-447	305	CCCCGGCGCGGGCACUAGC	306	ccccGGcGcGGGcAcuAGcdTsdT	sense

428-447	307	GCUAGUGCCCGCGCCGGGG	308	GCuAGUGCCCGCGCCGGGGdTsdT	antis

429-448	309	CCCGGCGCGGGCACUAGCU	310	cccGGcGcGGGcAcuAGcudTsdT	sense

429-448	311	AGCUAGUGCCCGCGCCGGG	312	AGCuAGUGCCCGCGCCGGGdTsdT	antis

430-449	313	CCGGCGCGGGCACUAGCUU	314	ccGGcGcGGGcAcuAGcuudTsdT	sense

430-449	315	AAGCUAGUGCCCGCGCCGG	316	AAGCuAGUGCCCGCGCCGGdTsdT	antis

438-457	317	GGCACUAGCUUCCCGCCGC	318	GGcAcuAGcuucccGccGcdTsdT	sense

438-457	319	GCGGCGGGAAGCUAGUGCC	320	GCGGCGGGAAGCuAGUGCCdTsdT	antis

583-602	321	GAGUAGUAUACCAGGCACG	322	GAGuAGuAuAccAGGcAcGdTsdT	sense

583-602	323	CGUGCCUGGUAUACUACUC	324	CGUGCCUGGuAuACuACUCdTsdT	antis

654-673	325	AGGUUCAAGAACCGAGAAC	326	AGGuucAAGAAccGAGAAcdTsdT	sense

654-673	327	GUUCUCGGUUCUUGAACCU	328	GUUCUCGGUUCUUGAACCUdTsdT	antis

667-686	329	GAGAACUGCAGAUUAUGCG	330	GAGAAcuGcAGAuuAuGcGdTsdT	sense

667-686	331	CGCAUAAUCUGCAGUUCUC	332	CGcAuAAUCUGcAGUUCUCdTsdT	antis

928-947	333	AGCCCCAGAAUUUGCUUGU	334	AGccccAGAAuuuGcuuGudTsdT	sense

928-947	335	ACAAGCAAAUUCUGGGGCU	336	AcAAGcAAAUUCUGGGGCUdTsdT	antis

994-1013	337	AGCAGCUGGUUCGGGGGGA	338	AGcAGcuGGuucGGGGGGAdTsdT	sense

994-1013	339	UCCCCCCGAACCAGCUGCU	340	UCCCCCCGAACcAGCUGCUdTsdT	antis

1005-1024	341	CGGGGGGAGCCCAAUGUGU	342	cGGGGGGAGcccAAuGuGudTsdT	sense

1005-1024	343	ACACAUUGGGCUCCCCCCG	344	AcAcAUUGGGCUCCCCCCGdTsdT	antis

1008-1027	345	GGGGAGCCCAAUGUGUCCU	346	GGGGAGcccAAuGuGuccudTsdT	sense

1008-1027	347	AGGACACAUUGGGCUCCCC	348	AGGAcAcAUUGGGCUCCCCdTsdT	antis

1124-1143	349	UGAGCUACUUCUCGGCCAG	350	uGAGcuAcuucucGGccAGdTsdT	sense

1124-1143	351	CUGGCCGAGAAGUAGCUCA	352	CUGGCCGAGAAGuAGCUcAdTsdT	antis

1303-1322	353	CAAAGACACCACCUGAGGC	354	cAAAGAcAccAccuGAGGcdTsdT	sense

1303-1322	355	GCCUCAGGUGGUGUCUUUG	356	GCCUcAGGUGGUGUCUUUGdTsdT	antis

1311-1330	357	CCACCUGAGGCCAUUGCAC	358	ccAccuGAGGccAuuGcAcdTsdT	sense

1311-1330	359	GUGCAAUGGCCUCAGGUGG	360	GUGcAAUGGCCUcAGGUGGdTsdT	antis

1444-1463	361	GCCCGCUUCCCCCCCUGUU	362	GcccGcuucccccccuGuudTsdT	sense

1444-1463	363	AACAGGGGGGGAAGCGGGC	364	AAcAGGGGGGGAAGCGGGCdTsdT	antis

1488-1507	365	AUCCAACCAUCUCUCAAUG	366	AuccAAccAucucucAAuGdTsdT	sense

1488-1507	367	CAUUGAGAGAUGGUUGGAU	368	cAUUGAGAGAUGGUUGGAUdTsdT	antis

1851-1870	369	AUUUUAACUGUUUGUAGGG	370	AuuuuAAcuGuuuGuAGGGdTsdT	sense

1851-1870	371	CCCUACAAACAGUUAAAAU	372	CCCuAcAAAcAGUuAAAAUdTsdT	antis

1852-1871	373	UUUUAACUGUUUGUAGGGG	374	uuuuAAcuGuuuGuAGGGGdTsdT	sense

1852-1871	375	CCCCUACAAACAGUUAAAA	376	CCCCuAcAAAcAGUuAAAAdTsdT	antis

1935-1954	377	CUCCCCCAGGCUACCACUC	378	cucccccAGGcuAccAcucdTsdT	sense

1935-1954	379	GAGUGGUAGCCUGGGGGAG	380	GAGUGGuAGCCUGGGGGAGdTsdT	antis

1975-1994	381	GGUCCCUUGUAAAUAGAAC	382	GGucccuuGuAAAuAGAAcdTsdT	sense

1975-1994	383	GUUCUAUUUACAAGGGACC	384	GUUCuAUUuAcAAGGGACCdTsdT	antis

2029-2048	385	CCCCUGGGUGUAAAUAGAU	386	ccccuGGGuGuAAAuAGAudTsdT	sense

2029-2048	387	AUCUAUUUACACCCAGGGG	388	AUCuAUUuAcACCcAGGGGdTsdT	antis

2033-2052	389	UGGGUGUAAAUAGAUUGUU	390	uGGGuGuAAAuAGAuuGuudTsdT	sense

2033-2052	391	AACAAUCUAUUUACACCCA	392	AAcAAUCuAUUuAcACCcAdTsdT	antis

2062-2081	393	CUUAAAGAAAACGUCAAUU	394	cuuAAAGAAAAcGucAAuudTsdT	sense

2062-2081	395	AAUUGACGUUUUCUUUAAG	396	AAUUGACGUUUUCUUuAAGdTsdT	antis

2063-2082	397	UUAAAGAAAACGUCAAUUC	398	uuAAAGAAAAcGucAAuucdTsdT	sense

2063-2082	399	GAAUUGACGUUUUCUUUAA	400	GAAUUGACGUUUUCUUuAAdTsdT	antis

2078-2097	401	AUUCACACCAUUCAACUUG	402	AuucAcAccAuucAAcuuGdTsdT	sense

2078-2097	403	CAAGUUGAAUGGUGUGAAU	404	cAAGUUGAAUGGUGUGAAUdTsdT	antis

2082-2101	405	ACACCAUUCAACUUGCCCC	406	AcAccAuucAAcuuGccccdTsdT	sense

2082-2101	407	GGGGCAAGUUGAAUGGUGU	408	GGGGcAAGUUGAAUGGUGUdTsdT	antis

2181-2200	409	UCCCUGGUGUCUUAGUUUC	410	ucccuGGuGucuuAGuuucdTsdT	sense

2181-2200	411	GAAACUAAGACACCAGGGA	412	GAAACuAAGAcACcAGGGAdTsdT	antis

2197-2216	413	UUCCACAGUAAGGUUUGCC	414	uuccAcAGuAAGGuuuGccdTsdT	sense

2197-2216	415	GGCAAACCUUACUGUGGAA	416	GGcAAACCUuACUGUGGAAdTsdT	antis

2209-2228	417	GUUUGCCUGUGUACAGACC	418	GuuuGccuGuGuAcAGAccdTsdT	sense

2209-2228	419	GGUCUGUACACAGGCAAAC	420	GGUCUGuAcAcAGGcAAACdTsdT	antis

2232-2251	421	UUCAAUAAAUUAUUGGCAU	422	uucAAuAAAuuAuuGGcAudTsdT	sense

2232-2251	423	AUGCCAAUAAUUUAUUGAA	424	AUGCcAAuAAUUuAUUGAAdTsdT	antis

2235-2254	425	AAUAAAUUAUUGGCAUGAA	426	AAuAAAuuAuuGGcAuGAAdTsdT	sense

2235-2254	427	UUCAUGCCAAUAAUUUAUU	428	UUcAUGCcAAuAAUUuAUUdTsdT	antis

2243-2262	429	AUUGGCAUGAAACCCUUAA	430	AuuGGcAuGAAAcccuuAAdTsdT	sense

2243-2262	431	UUAAGGGUUUCAUGCCAAU	432	UuAAGGGUUUcAUGCcAAUdTsdT	antis

336-355	433	GGGAAAGCGUCAGUCGGGG	434	GGGAAAGcGucAGucGGGGdTsdT	sense

336-355	435	CCCCGACUGACGCUUUCCC	436	CCCCGACUGACGCUUUCCCdTsdT	antis

894-913	437	AUCCACUCCCAAGGUGUGU	438	AuccAcucccAAGGuGuGudTsdT	sense

894-913	439	ACACACCUUGGGAGUGGAU	440	AcAcACCUUGGGAGUGGAUdTsdT	antis

1070-1089	441	AGCCACAGAUUACACCUCG	442	AGccAcAGAuuAcAccucGdTsdT	sense

1070-1089	443	CGAGGUGUAAUCUGUGGCU	444	CGAGGUGuAAUCUGUGGCUdTsdT	antis

1346-1365	445	GGAGUACACGCCAUCCUCA	446	GGAGuAcAcGccAuccucAdTsdT	sense

1346-1365	447	UGAGGAUGGCGUGUACUCC	448	UGAGGAUGGCGUGuACUCCdTsdT	antis

1976-1995	449	GUCCCUUGUAAAUAGAACC	450	GucccuuGuAAAuAGAAccdTsdT	sense

1976-1995	451	GGUUCUAUUUACAAGGGAC	452	GGUUCuAUUuAcAAGGGACdTsdT	antis

1977-1996	453	UCCCUUGUAAAUAGAACCA	454	ucccuuGuAAAuAGAAccAdTsdT	sense

1977-1996	455	UGGUUCUAUUUACAAGGGA	456	UGGUUCuAUUuAcAAGGGAdTsdT	antis

2194-2213	457	AGUUUCCACAGUAAGGUUU	458	AGuuuccAcAGuAAGGuuudTsdT	sense

2194-2213	459	AAACCUUACUGUGGAAACU	460	AAACCUuACUGUGGAAACUdTsdT	antis

1229-1248	461	GAUGAACCCUAACUAUACG	462	GAuGAAcccuAAcuAuAcGdTsdT	sense

1229-1248	463	CGUAUAGUUAGGGUUCAUC	464	CGuAuAGUuAGGGUUcAUCdTsdT	antis

341-360	465	AGCGUCAGUCGGGGCUAUG	466	AGcGucAGucGGGGcuAuGdTsdT	sense

341-360	467	CAUAGCCCCGACUGACGCU	468	cAuAGCCCCGACUGACGCUdTsdT	antis

574-593	469	GCUCAUUCGGAGUAGUAUA	470	GcucAuucGGAGuAGuAuAdTsdT	sense

574-593	471	UAUACUACUCCGAAUGAGC	472	uAuACuACUCCGAAUGAGCdTsdT	antis

578-597	473	AUUCGGAGUAGUAUACCAG	474	AuucGGAGuAGuAuAccAGdTsdT	sense

578-597	475	CUGGUAUACUACUCCGAAU	476	CUGGuAuACuACUCCGAAUdTsdT	antis

672-691	477	CUGCAGAUUAUGCGUAAGC	478	cuGcAGAuuAuGcGuAAGcdTsdT	sense

672-691	479	GCUUACGCAUAAUCUGCAG	480	GCUuACGcAuAAUCUGcAGdTsdT	antis

673-692	481	UGCAGAUUAUGCGUAAGCU	482	uGcAGAuuAuGcGuAAGcudTsdT	sense

673-692	483	AGCUUACGCAUAAUCUGCA	484	AGCUuACGcAuAAUCUGcAdTsdT	antis

674-693	485	GCAGAUUAUGCGUAAGCUG	486	GcAGAuuAuGcGuAAGcuGdTsdT	sense

674-693	487	CAGCUUACGCAUAAUCUGC	488	cAGCUuACGcAuAAUCUGCdTsdT	antis

1433-1452	489	CCCCAACGACCGCCCGCUU	490	ccccAAcGAccGcccGcuudTsdT	sense

1433-1452	491	AAGCGGGCGGUCGUUGGGG	492	AAGCGGGCGGUCGUUGGGGdTsdT	antis

1434-1453	493	CCCAACGACCGCCCGCUUC	494	cccAAcGAccGcccGcuucdTsdT	sense

1434-1453	495	GAAGCGGGCGGUCGUUGGG	496	GAAGCGGGCGGUCGUUGGGdTsdT	antis

1640-1659	497	UGCUACCCUCGCUAGCUCU	498	uGcuAcccucGcuAGcucudTsdT	sense

1640-1659	499	AGAGCUAGCGAGGGUAGCA	500	AGAGCuAGCGAGGGuAGcAdTsdT	antis

458-477	501	GGGAGUGAAGCUGGGCCGU	502	GGGAGuGAAGcuGGGccGudTsdT	sense

458-477	503	ACGGCCCAGCUUCACUCCC	504	ACGGCCcAGCUUcACUCCCdTsdT	antis

459-478	505	GGAGUGAAGCUGGGCCGUG	506	GGAGuGAAGcuGGGccGuGdTsdT	sense

459-478	507	CACGGCCCAGCUUCACUCC	508	cACGGCCcAGCUUcACUCCdTsdT	antis

573-592	509	GGCUCAUUCGGAGUAGUAU	510	GGcucAuucGGAGuAGuAudTsdT	sense

573-592	511	AUACUACUCCGAAUGAGCC	512	AuACuACUCCGAAUGAGCCdTsdT	antis

575-594	513	CUCAUUCGGAGUAGUAUAC	514	cucAuucGGAGuAGuAuAcdTsdT	sense

575-594	515	GUAUACUACUCCGAAUGAG	516	GuAuACuACUCCGAAUGAGdTsdT	antis

576-595	517	UCAUUCGGAGUAGUAUACC	518	ucAuucGGAGuAGuAuAccdTsdT	sense

576-595	519	GGUAUACUACUCCGAAUGA	520	GGuAuACuACUCCGAAUGAdTsdT	antis

577-596	521	CAUUCGGAGUAGUAUACCA	522	cAuucGGAGuAGuAuAccAdTsdT	sense

577-596	523	UGGUAUACUACUCCGAAUG	524	UGGuAuACuACUCCGAAUGdTsdT	antis

579-598	525	UUCGGAGUAGUAUACCAGG	526	uucGGAGuAGuAuAccAGGdTsdT	sense

579-598	527	CCUGGUAUACUACUCCGAA	528	CCUGGuAuACuACUCCGAAdTsdT	antis

671-690	529	ACUGCAGAUUAUGCGUAAG	530	AcuGcAGAuuAuGcGuAAGdTsdT	sense

671-690	531	CUUACGCAUAAUCUGCAGU	532	CUuACGcAuAAUCUGcAGUdTsdT	antis

786-805	533	CCCGAGACGGUGUACCGAG	534	cccGAGAcGGuGuAccGAGdTsdT	sense

786-805	535	CUCGGUACACCGUCUCGGG	536	CUCGGuAcACCGUCUCGGGdTsdT	antis

787-806	537	CCGAGACGGUGUACCGAGU	538	ccGAGAcGGuGuAccGAGudTsdT	sense

787-806	539	ACUCGGUACACCGUCUCGG	540	ACUCGGuAcACCGUCUCGGdTsdT	antis

789-808	541	GAGACGGUGUACCGAGUGG	542	GAGAcGGuGuAccGAGuGGdTsdT	sense

789-808	543	CCACUCGGUACACCGUCUC	544	CcACUCGGuAcACCGUCUCdTsdT	antis

1065-1084	545	UUUGGAGCCACAGAUUACA	546	uuuGGAGccAcAGAuuAcAdTsdT	sense

1065-1084	547	UGUAAUCUGUGGCUCCAAA	548	UGuAAUCUGUGGCUCcAAAdTsdT	antis

1226-1245	549	AGAGAUGAACCCUAACUAU	550	AGAGAuGAAcccuAAcuAudTsdT	sense

1226-1245	551	AUAGUUAGGGUUCAUCUCU	552	AuAGUuAGGGUUcAUCUCUdTsdT	antis

1228-1247	553	AGAUGAACCCUAACUAUAC	554	AGAuGAAcccuAAcuAuAcdTsdT	sense

1228-1247	555	GUAUAGUUAGGGUUCAUCU	556	GuAuAGUuAGGGUUcAUCUdTsdT	antis

1636-1655	557	CAACUGCUACCCUCGCUAG	558	cAAcuGcuAcccucGcuAGdTsdT	sense

1636-1655	559	CUAGCGAGGGUAGCAGUUG	560	CuAGCGAGGGuAGcAGUUGdTsdT	antis

1639-1658	561	CUGCUACCCUCGCUAGCUC	562	cuGcuAcccucGcuAGcucdTsdT	sense

1639-1658	563	GAGCUAGCGAGGGUAGCAG	564	GAGCuAGCGAGGGuAGcAGdTsdT	antis

2036-2055	565	GUGUAAAUAGAUUGUUAUA	566	GuGuAAAuAGAuuGuuAuAdTsdT	sense

2036-2055	567	UAUAACAAUCUAUUUACAC	568	uAuAAcAAUCuAUUuAcACdTsdT	antis

426-445	569	GGCCCCGGCGCGGGCACUA	570	GGccccGGcGcGGGcAcuAdTsdT	sense

426-445	571	UAGUGCCCGCGCCGGGGCC	572	uAGUGCCCGCGCCGGGGCCdTsdT	antis

883-902	573	GCUUGGCCUACAUCCACUC	574	GcuuGGccuAcAuccAcucdTsdT	sense

883-902	575	GAGUGGAUGUAGGCCAAGC	576	GAGUGGAUGuAGGCcAAGCdTsdT	antis

1227-1246	577	GAGAUGAACCCUAACUAUA	578	GAGAuGAAcccuAAcuAuAdTsdT	sense

1227-1246	579	UAUAGUUAGGGUUCAUCUC	580	uAuAGUuAGGGUUcAUCUCdTsdT	antis

1369-1388	581	UCUCCCCACUCGAGGCUUG	582	ucuccccAcucGAGGcuuGdTsdT	sense

1369-1388	583	CAAGCCUCGAGUGGGGAGA	584	cAAGCCUCGAGUGGGGAGAdTsdT	antis

1393-1412	585	ACAGCUUCUUCGAUGAACU	586	AcAGcuucuucGAuGAAcudTsdT	sense

1393-1412	587	AGUUCAUCGAAGAAGCUGU	588	AGUUcAUCGAAGAAGCUGUdTsdT	antis

1431-1450	589	CUCCCCAACGACCGCCCGC	590	cuccccAAcGAccGcccGcdTsdT	sense

1431-1450	591	GCGGGCGGUCGUUGGGGAG	592	GCGGGCGGUCGUUGGGGAGdTsdT	antis

1436-1455	593	CAACGACCGCCCGCUUCCC	594	cAAcGAccGcccGcuucccdTsdT	sense

1436-1455	595	GGGAAGCGGGCGGUCGUUG	596	GGGAAGCGGGCGGUCGUUGdTsdT	antis

1437-1456	597	AACGACCGCCCGCUUCCCC	598	AAcGAccGcccGcuuccccdTsdT	sense

1437-1456	599	GGGGAAGCGGGCGGUCGUU	600	GGGGAAGCGGGCGGUCGUUdTsdT	antis

2176-2195	601	GAGAGUCCCUGGUGUCUUA	602	GAGAGucccuGGuGucuuAdTsdT	sense

2176-2195	603	UAAGACACCAGGGACUCUC	604	uAAGAcACcAGGGACUCUCdTsdT	antis

599-618	605	ACGGCUGGCAGAGACGAGG	606	AcGGcuGGcAGAGAcGAGGdTsdT	sense

599-618	607	CCUCGUCUCUGCCAGCCGU	608	CCUCGUCUCUGCcAGCCGUdTsdT	antis

706-725	609	UUGUGAGGCUGCGGUACUU	610	uuGuGAGGcuGcGGuAcuudTsdT	sense

706-725	611	AAGUACCGCAGCCUCACAA	612	AAGuACCGcAGCCUcAcAAdTsdT	antis

707-726	613	UGUGAGGCUGCGGUACUUU	614	uGuGAGGcuGcGGuAcuuudTsdT	sense

707-726	615	AAAGUACCGCAGCCUCACA	616	AAAGuACCGcAGCCUcAcAdTsdT	antis

791-810	617	GACGGUGUACCGAGUGGCC	618	GAcGGuGuAccGAGuGGccdTsdT	sense

791-810	619	GGCCACUCGGUACACCGUC	620	GGCcACUCGGuAcACCGUCdTsdT	antis

899-918	621	CUCCCAAGGUGUGUGUCAC	622	cucccAAGGuGuGuGucAcdTsdT	sense

899-918	623	GUGACACACACCUUGGGAG	624	GUGAcAcAcACCUUGGGAGdTsdT	antis

989-1008	625	UGCAAAGCAGCUGGUUCGG	626	uGcAAAGcAGcuGGuucGGdTsdT	sense

989-1008	627	CCGAACCAGCUGCUUUGCA	628	CCGAACcAGCUGCUUUGcAdTsdT	antis

1064-1083	629	CUUUGGAGCCACAGAUUAC	630	cuuuGGAGccAcAGAuuAcdTsdT	sense

1064-1083	631	GUAAUCUGUGGCUCCAAAG	632	GuAAUCUGUGGCUCcAAAGdTsdT	antis

1066-1085	633	UUGGAGCCACAGAUUACAC	634	uuGGAGccAcAGAuuAcAcdTsdT	sense

1066-1085	635	GUGUAAUCUGUGGCUCCAA	636	GUGuAAUCUGUGGCUCcAAdTsdT	antis

1125-1144	637	GAGCUACUUCUCGGCCAGC	638	GAGcuAcuucucGGccAGcdTsdT	sense

1125-1144	639	GCUGGCCGAGAAGUAGCUC	640	GCUGGCCGAGAAGuAGCUCdTsdT	antis

1225-1244	641	GAGAGAUGAACCCUAACUA	642	GAGAGAuGAAcccuAAcuAdTsdT	sense

1225-1244	643	UAGUUAGGGUUCAUCUCUC	644	uAGUuAGGGUUcAUCUCUCdTsdT	antis

1265-1284	645	GAUCAAAGCUCACCCUUGG	646	GAucAAAGcucAcccuuGGdTsdT	sense

1265-1284	647	CCAAGGGUGAGCUUUGAUC	648	CcAAGGGUGAGCUUUGAUCdTsdT	antis

1269-1288	649	AAAGCUCACCCUUGGACAA	650	AAAGcucAcccuuGGAcAAdTsdT	sense

1269-1288	651	UUGUCCAAGGGUGAGCUUU	652	UUGUCcAAGGGUGAGCUUUdTsdT	antis

1365-1384	653	AGGCUCUCCCCACUCGAGG	654	AGGcucuccccAcucGAGGdTsdT	sense

1365-1384	655	CCUCGAGUGGGGAGAGCCU	656	CCUCGAGUGGGGAGAGCCUdTsdT	antis

1481-1500	657	ACUGUCCAUCCAACCAUCU	658	AcuGuccAuccAAccAucudTsdT	sense

1481-1500	659	AGAUGGUUGGAUGGACAGU	660	AGAUGGUUGGAUGGAcAGUdTsdT	antis

1637-1656	661	AACUGCUACCCUCGCUAGC	662	AAcuGcuAcccucGcuAGcdTsdT	sense

1637-1656	663	GCUAGCGAGGGUAGCAGUU	664	GCuAGCGAGGGuAGcAGUUdTsdT	antis

1979-1998	665	CCUUGUAAAUAGAACCAGC	666	ccuuGuAAAuAGAAccAGcdTsdT	sense

1979-1998	667	GCUGGUUCUAUUUACAAGG	668	GCUGGUUCuAUUuAcAAGGdTsdT	antis

2196-2215	669	UUUCCACAGUAAGGUUUGC	670	uuuccAcAGuAAGGuuuGcdTsdT	sense

2196-2215	671	GCAAACCUUACUGUGGAAA	672	GcAAACCUuACUGUGGAAAdTsdT	antis

1978-1997	673	CCCUUGUAAAUAGAACCAG	674	cccuuGuAAAuAGAAccAGdTsdT	sense

1978-1997	675	CUGGUUCUAUUUACAAGGG	676	CUGGUUCuAUUuAcAAGGGdTsdT	antis

651-670	677	AAAAGGUUCAAGAACCGAG	678	AAAAGGuucAAGAAccGAGdTsdT	sense

651-670	679	CUCGGUUCUUGAACCUUUU	680	CUCGGUUCUUGAACCUUUUdTsdT	antis

702-721	681	AAUAUUGUGAGGCUGCGGU	682	AAuAuuGuGAGGcuGcGGudTsdT	sense

702-721	683	ACCGCAGCCUCACAAUAUU	684	ACCGcAGCCUcAcAAuAUUdTsdT	antis

1363-1382	685	CAAGGCUCUCCCCACUCGA	686	cAAGGcucuccccAcucGAdTsdT	sense

1363-1382	687	UCGAGUGGGGAGAGCCUUG	688	UCGAGUGGGGAGAGCCUUGdTsdT	antis

701-720	689	CAAUAUUGUGAGGCUGCGG	690	cAAuAuuGuGAGGcuGcGGdTsdT	sense

701-720	691	CCGCAGCCUCACAAUAUUG	692	CCGcAGCCUcAcAAuAUUGdTsdT	antis

1237-1256	693	CUAACUAUACGGAGUUCAA	694	cuAAcuAuAcGGAGuucAAdTsdT	sense

1237-1256	695	UUGAACUCCGUAUAGUUAG	696	UUGAACUCCGuAuAGUuAGdTsdT	antis

2064-2083	697	UAAAGAAAACGUCAAUUCA	698	uAAAGAAAAcGucAAuucAdTsdT	sense

2064-2083	699	UGAAUUGACGUUUUCUUUA	700	UGAAUUGACGUUUUCUUuAdTsdT	antis

828-847	701	AAGCUGAUCACCCCUAUCA	702	AAGcuGAucAccccuAucAdTsdT	sense

828-847	703	UGAUAGGGGUGAUCAGCUU	704	UGAuAGGGGUGAUcAGCUUdTsdT	antis

930-949	705	CCCCAGAAUUUGCUUGUGG	706	ccccAGAAuuuGcuuGuGGdTsdT	sense

930-949	707	CCACAAGCAAAUUCUGGGG	708	CcAcAAGcAAAUUCUGGGGdTsdT	antis

995-1014	709	GCAGCUGGUUCGGGGGGAG	710	GcAGcuGGuucGGGGGGAGdTsdT	sense

995-1014	711	CUCCCCCCGAACCAGCUGC	712	CUCCCCCCGAACcAGCUGCdTsdT	antis

1478-1497	713	UGAACUGUCCAUCCAACCA	714	uGAAcuGuccAuccAAccAdTsdT	sense

1478-1497	715	UGGUUGGAUGGACAGUUCA	716	UGGUUGGAUGGAcAGUUcAdTsdT	antis

1604-1623	717	GACUGGCCAAGAUUGGCAG	718	GAcuGGccAAGAuuGGcAGdTsdT	sense

1604-1623	719	CUGCCAAUCUUGGCCAGUC	720	CUGCcAAUCUUGGCcAGUCdTsdT	antis

1808-1827	721	CUCCCUCAGCAGCCUAACC	722	cucccucAGcAGccuAAccdTsdT	sense

1808-1827	723	GGUUAGGCUGCUGAGGGAG	724	GGUuAGGCUGCUGAGGGAGdTsdT	antis

2177-2196	725	AGAGUCCCUGGUGUCUUAG	726	AGAGucccuGGuGucuuAGdTsdT	sense

2177-2196	727	CUAAGACACCAGGGACUCU	728	CuAAGAcACcAGGGACUCUdTsdT	antis

82-101	729	GAACGGCGCGGCCUGGAAG	730	GAAcGGcGcGGccuGGAAGdTsdT	sense

82-101	731	CUUCCAGGCCGCGCCGUUC	732	CUUCcAGGCCGCGCCGUUCdTsdT	antis

1077-1096	733	GAUUACACCUCGUCCAUCG	734	GAuuAcAccucGuccAucGdTsdT	sense

1077-1096	735	CGAUGGACGAGGUGUAAUC	736	CGAUGGACGAGGUGuAAUCdTsdT	antis

1238-1257	737	UAACUAUACGGAGUUCAAG	738	uAAcuAuAcGGAGuucAAGdTsdT	sense

1238-1257	739	CUUGAACUCCGUAUAGUUA	740	CUUGAACUCCGuAuAGUuAdTsdT	antis

248-267	741	CAGCUCGUUCGCGGAGCCA	742	cAGcucGuucGcGGAGccAdTsdT	sense

248-267	743	UGGCUCCGCGAACGAGCUG	744	UGGCUCCGCGAACGAGCUGdTsdT	antis

250-269	745	GCUCGUUCGCGGAGCCAGG	746	GcucGuucGcGGAGccAGGdTsdT	sense

250-269	747	CCUGGCUCCGCGAACGAGC	748	CCUGGCUCCGCGAACGAGCdTsdT	antis

327-346	749	ACUGGCGGCGGGAAAGCGU	750	AcuGGcGGcGGGAAAGcGudTsdT	sense

327-346	751	ACGCUUUCCCGCCGCCAGU	752	ACGCUUUCCCGCCGCcAGUdTsdT	antis

332-351	753	CGGCGGGAAAGCGUCAGUC	754	cGGcGGGAAAGcGucAGucdTsdT	sense

332-351	755	GACUGACGCUUUCCCGCCG	756	GACUGACGCUUUCCCGCCGdTsdT	antis

376-395	757	CCUCGAGCUCCGGGGGUGG	758	ccucGAGcuccGGGGGuGGdTsdT	sense

376-395	759	CCACCCCCGGAGCUCGAGG	760	CcACCCCCGGAGCUCGAGGdTsdT	antis

468-487	761	CUGGGCCGUGACAGCGGGA	762	cuGGGccGuGAcAGcGGGAdTsdT	sense

468-487	763	UCCCGCUGUCACGGCCCAG	764	UCCCGCUGUcACGGCCcAGdTsdT	antis

584-603	765	AGUAGUAUACCAGGCACGG	766	AGuAGuAuAccAGGcAcGGdTsdT	sense

584-603	767	CCGUGCCUGGUAUACUACU	768	CCGUGCCUGGuAuACuACUdTsdT	antis

785-804	769	GCCCGAGACGGUGUACCGA	770	GcccGAGAcGGuGuAccGAdTsdT	sense

785-804	771	UCGGUACACCGUCUCGGGC	772	UCGGuAcACCGUCUCGGGCdTsdT	antis

1010-1029	773	GGAGCCCAAUGUGUCCUAC	774	GGAGcccAAuGuGuccuAcdTsdT	sense

1010-1029	775	GUAGGACACAUUGGGCUCC	776	GuAGGAcAcAUUGGGCUCCdTsdT	antis

1011-1030	777	GAGCCCAAUGUGUCCUACA	778	GAGcccAAuGuGuccuAcAdTsdT	sense

1011-1030	779	UGUAGGACACAUUGGGCUC	780	UGuAGGAcAcAUUGGGCUCdTsdT	antis

1021-1040	781	UGUCCUACAUCUGCUCUCG	782	uGuccuAcAucuGcucucGdTsdT	sense

1021-1040	783	CGAGAGCAGAUGUAGGACA	784	CGAGAGcAGAUGuAGGAcAdTsdT	antis

1022-1041	785	GUCCUACAUCUGCUCUCGG	786	GuccuAcAucuGcucucGGdTsdT	sense

1022-1041	787	CCGAGAGCAGAUGUAGGAC	788	CCGAGAGcAGAUGuAGGACdTsdT	antis

1023-1042	789	UCCUACAUCUGCUCUCGGU	790	uccuAcAucuGcucucGGudTsdT	sense

1023-1042	791	ACCGAGAGCAGAUGUAGGA	792	ACCGAGAGcAGAUGuAGGAdTsdT	antis

1072-1091	793	CCACAGAUUACACCUCGUC	794	ccAcAGAuuAcAccucGucdTsdT	sense

1072-1091	795	GACGAGGUGUAAUCUGUGG	796	GACGAGGUGuAAUCUGUGGdTsdT	antis

1127-1146	797	GCUACUUCUCGGCCAGCCC	798	GcuAcuucucGGccAGcccdTsdT	sense

1127-1146	799	GGGCUGGCCGAGAAGUAGC	800	GGGCUGGCCGAGAAGuAGCdTsdT	antis

1408-1427	801	AACUGCGGAGACUCGGAGC	802	AAcuGcGGAGAcucGGAGcdTsdT	sense

1408-1427	803	GCUCCGAGUCUCCGCAGUU	804	GCUCCGAGUCUCCGcAGUUdTsdT	antis

1432-1451	805	UCCCCAACGACCGCCCGCU	806	uccccAAcGAccGcccGcudTsdT	sense

1432-1451	807	AGCGGGCGGUCGUUGGGGA	808	AGCGGGCGGUCGUUGGGGAdTsdT	antis

1982-2001	809	UGUAAAUAGAACCAGCCCA	810	uGuAAAuAGAAccAGcccAdTsdT	sense

1982-2001	811	UGGGCUGGUUCUAUUUACA	812	UGGGCUGGUUCuAUUuAcAdTsdT	antis

2030-2049	813	CCCUGGGUGUAAAUAGAUU	814	cccuGGGuGuAAAuAGAuudTsdT	sense

2030-2049	815	AAUCUAUUUACACCCAGGG	816	AAUCuAUUuAcACCcAGGGdTsdT	antis

2073-2092	817	CGUCAAUUCACACCAUUCA	818	cGucAAuucAcAccAuucAdTsdT	sense

2073-2092	819	UGAAUGGUGUGAAUUGACG	820	UGAAUGGUGUGAAUUGACGdTsdT	antis

2218-2237	821	UGUACAGACCUCUGUUCAA	822	uGuAcAGAccucuGuucAAdTsdT	sense

2218-2237	823	UUGAACAGAGGUCUGUACA	824	UUGAAcAGAGGUCUGuAcAdTsdT	antis

2229-2248	825	CUGUUCAAUAAAUUAUUGG	826	cuGuucAAuAAAuuAuuGGdTsdT	sense

2229-2248	827	CCAAUAAUUUAUUGAACAG	828	CcAAuAAUUuAUUGAAcAGdTsdT	antis

7-26	829	ACAACGAAGCCGACGGCAG	830	AcAAcGAAGccGAcGGcAGdTsdT	sense

7-26	831	CUGCCGUCGGCUUCGUUGU	832	CUGCCGUCGGCUUCGUUGUdTsdT	antis

8-27	833	CAACGAAGCCGACGGCAGA	834	cAAcGAAGccGAcGGcAGAdTsdT	sense

8-27	835	UCUGCCGUCGGCUUCGUUG	836	UCUGCCGUCGGCUUCGUUGdTsdT	antis

76-95	837	GAGCCCGAACGGCGCGGCC	838	GAGcccGAAcGGcGcGGccdTsdT	sense

76-95	839	GGCCGCGCCGUUCGGGCUC	840	GGCCGCGCCGUUCGGGCUCdTsdT	antis

176-195	841	GCCUGCGCUCGGCGCCAUG	842	GccuGcGcucGGcGccAuGdTsdT	sense

176-195	843	CAUGGCGCCGAGCGCAGGC	844	cAUGGCGCCGAGCGcAGGCdTsdT	antis

434-453	845	CGCGGGCACUAGCUUCCCG	846	cGcGGGcAcuAGcuucccGdTsdT	sense

434-453	847	CGGGAAGCUAGUGCCCGCG	848	CGGGAAGCuAGUGCCCGCGdTsdT	antis

472-491	849	GCCGUGACAGCGGGAAGGU	850	GccGuGAcAGcGGGAAGGudTsdT	sense

472-491	851	ACCUUCCCGCUGUCACGGC	852	ACCUUCCCGCUGUcACGGCdTsdT	antis

537-556	853	GAAGUGGCUUACACUGACA	854	GAAGuGGcuuAcAcuGAcAdTsdT	sense

537-556	855	UGUCAGUGUAAGCCACUUC	856	UGUcAGUGuAAGCcACUUCdTsdT	antis

656-675	857	GUUCAAGAACCGAGAACUG	858	GuucAAGAAccGAGAAcuGdTsdT	sense

656-675	859	CAGUUCUCGGUUCUUGAAC	860	cAGUUCUCGGUUCUUGAACdTsdT	antis

657-676	861	UUCAAGAACCGAGAACUGC	862	uucAAGAAccGAGAAcuGcdTsdT	sense

657-676	863	GCAGUUCUCGGUUCUUGAA	864	GcAGUUCUCGGUUCUUGAAdTsdT	antis

784-803	865	UGCCCGAGACGGUGUACCG	866	uGcccGAGAcGGuGuAccGdTsdT	sense

784-803	867	CGGUACACCGUCUCGGGCA	868	CGGuAcACCGUCUCGGGcAdTsdT	antis

1404-1423	869	GAUGAACUGCGGAGACUCG	870	GAuGAAcuGcGGAGAcucGdTsdT	sense

1404-1423	871	CGAGUCUCCGCAGUUCAUC	872	CGAGUCUCCGcAGUUcAUCdTsdT	antis

1405-1424	873	AUGAACUGCGGAGACUCGG	874	AuGAAcuGcGGAGAcucGGdTsdT	sense

1405-1424	875	CCGAGUCUCCGCAGUUCAU	876	CCGAGUCUCCGcAGUUcAUdTsdT	antis

1445-1464	877	CCCGCUUCCCCCCCUGUUC	878	cccGcuucccccccuGuucdTsdT	sense

1445-1464	879	GAACAGGGGGGGAAGCGGG	880	GAAcAGGGGGGGAAGCGGGdTsdT	antis

1446-1465	881	CCGCUUCCCCCCCUGUUCA	882	ccGcuucccccccuGuucAdTsdT	sense

1446-1465	883	UGAACAGGGGGGGAAGCGG	884	UGAAcAGGGGGGGAAGCGGdTsdT	antis

1470-1489	885	AGUCCUGGUGAACUGUCCA	886	AGuccuGGuGAAcuGuccAdTsdT	sense

1470-1489	887	UGGACAGUUCACCAGGACU	888	UGGAcAGUUcACcAGGACUdTsdT	antis

1897-1916	889	GGGGGUGUGAGGACCUUCU	890	GGGGGuGuGAGGAccuucudTsdT	sense

1897-1916	891	AGAAGGUCCUCACACCCCC	892	AGAAGGUCCUcAcACCCCCdTsdT	antis

1937-1956	893	CCCCCAGGCUACCACUCCU	894	cccccAGGcuAccAcuccudTsdT	sense

1937-1956	895	AGGAGUGGUAGCCUGGGGG	896	AGGAGUGGuAGCCUGGGGGdTsdT	antis

1981-2000	897	UUGUAAAUAGAACCAGCCC	898	uuGuAAAuAGAAccAGcccdTsdT	sense

1981-2000	899	GGGCUGGUUCUAUUUACAA	900	GGGCUGGUUCuAUUuAcAAdTsdT	antis

1985-2004	901	AAAUAGAACCAGCCCAGCC	902	AAAuAGAAccAGcccAGccdTsdT	sense

1985-2004	903	GGCUGGGCUGGUUCUAUUU	904	GGCUGGGCUGGUUCuAUUUdTsdT	antis

2061-2080	905	UCUUAAAGAAAACGUCAAU	906	ucuuAAAGAAAAcGucAAudTsdT	sense

2061-2080	907	AUUGACGUUUUCUUUAAGA	908	AUUGACGUUUUCUUuAAGAdTsdT	antis

2065-2084	909	AAAGAAAACGUCAAUUCAC	910	AAAGAAAAcGucAAuucAcdTsdT	sense

2065-2084	911	GUGAAUUGACGUUUUCUUU	912	GUGAAUUGACGUUUUCUUUdTsdT	antis

1-20	913	GUGGUGACAACGAAGCCGA	914	GuGGuGAcAAcGAAGccGAdTsdT	sense

1-20	915	UCGGCUUCGUUGUCACCAC	916	UCGGCUUCGUUGUcACcACdTsdT	antis

11-30	917	CGAAGCCGACGGCAGAGGG	918	cGAAGccGAcGGcAGAGGGdTsdT	sense

11-30	919	CCCUCUGCCGUCGGCUUCG	920	CCCUCUGCCGUCGGCUUCGdTsdT	antis

70-89	921	GAGCCGGAGCCCGAACGGC	922	GAGccGGAGcccGAAcGGcdTsdT	sense

70-89	923	GCCGUUCGGGCUCCGGCUC	924	GCCGUUCGGGCUCCGGCUCdTsdT	antis

73-92	925	CCGGAGCCCGAACGGCGCG	926	ccGGAGcccGAAcGGcGcGdTsdT	sense

73-92	927	CGCGCCGUUCGGGCUCCGG	928	CGCGCCGUUCGGGCUCCGGdTsdT	antis

150-169	929	CAGGCAGCCCGAGCCCCGC	930	cAGGcAGcccGAGccccGcdTsdT	sense

150-169	931	GCGGGGCUCGGGCUGCCUG	932	GCGGGGCUCGGGCUGCCUGdTsdT	antis

178-197	933	CUGCGCUCGGCGCCAUGAG	934	cuGcGcucGGcGccAuGAGdTsdT	sense

178-197	935	CUCAUGGCGCCGAGCGCAG	936	CUcAUGGCGCCGAGCGcAGdTsdT	antis

180-199	937	GCGCUCGGCGCCAUGAGCG	938	GcGcucGGcGccAuGAGcGdTsdT	sense

180-199	939	CGCUCAUGGCGCCGAGCGC	940	CGCUcAUGGCGCCGAGCGCdTsdT	antis

196-215	941	GCGGCGGCGGGCCUUCGGG	942	GcGGcGGcGGGccuucGGGdTsdT	sense

196-215	943	CCCGAAGGCCCGCCGCCGC	944	CCCGAAGGCCCGCCGCCGCdTsdT	antis

202-221	945	GCGGGCCUUCGGGAGGCGG	946	GcGGGccuucGGGAGGcGGdTsdT	sense

202-221	947	CCGCCUCCCGAAGGCCCGC	948	CCGCCUCCCGAAGGCCCGCdTsdT	antis

223-242	949	CUGGGGGCUCGGGCCGGGC	950	cuGGGGGcucGGGccGGGcdTsdT	sense

223-242	951	GCCCGGCCCGAGCCCCCAG	952	GCCCGGCCCGAGCCCCcAGdTsdT	antis

238-257	953	GGGCGCGGACCAGCUCGUU	954	GGGcGcGGAccAGcucGuudTsdT	sense

238-257	955	AACGAGCUGGUCCGCGCCC	956	AACGAGCUGGUCCGCGCCCdTsdT	antis

317-336	957	CCCAGGAGGCACUGGCGGC	958	cccAGGAGGcAcuGGcGGcdTsdT	sense

317-336	959	GCCGCCAGUGCCUCCUGGG	960	GCCGCcAGUGCCUCCUGGGdTsdT	antis

337-356	961	GGAAAGCGUCAGUCGGGGC	962	GGAAAGcGucAGucGGGGcdTsdT	sense

337-356	963	GCCCCGACUGACGCUUUCC	964	GCCCCGACUGACGCUUUCCdTsdT	antis

436-455	965	CGGGCACUAGCUUCCCGCC	966	cGGGcAcuAGcuucccGccdTsdT	sense

436-455	967	GGCGGGAAGCUAGUGCCCG	968	GGCGGGAAGCuAGUGCCCGdTsdT	antis

449-468	969	CCCGCCGCCGGGAGUGAAG	970	cccGccGccGGGAGuGAAGdTsdT	sense

449-468	971	CUUCACUCCCGGCGGCGGG	972	CUUcACUCCCGGCGGCGGGdTsdT	antis

464-483	973	GAAGCUGGGCCGUGACAGC	974	GAAGcuGGGccGuGAcAGcdTsdT	sense

464-483	975	GCUGUCACGGCCCAGCUUC	976	GCUGUcACGGCCcAGCUUCdTsdT	antis

534-553	977	CAAGAAGUGGCUUACACUG	978	cAAGAAGuGGcuuAcAcuGdTsdT	sense

534-553	979	CAGUGUAAGCCACUUCUUG	980	cAGUGuAAGCcACUUCUUGdTsdT	antis

535-554	981	AAGAAGUGGCUUACACUGA	982	AAGAAGuGGcuuAcAcuGAdTsdT	sense

535-554	983	UCAGUGUAAGCCACUUCUU	984	UcAGUGuAAGCcACUUCUUdTsdT	antis

536-555	985	AGAAGUGGCUUACACUGAC	986	AGAAGuGGcuuAcAcuGAcdTsdT	sense

536-555	987	GUCAGUGUAAGCCACUUCU	988	GUcAGUGuAAGCcACUUCUdTsdT	antis

821-840	989	CAAGGCCAAGCUGAUCACC	990	cAAGGccAAGcuGAucAccdTsdT	sense

821-840	991	GGUGAUCAGCUUGGCCUUG	992	GGUGAUcAGCUUGGCCUUGdTsdT	antis

826-845	993	CCAAGCUGAUCACCCCUAU	994	ccAAGcuGAucAccccuAudTsdT	sense

826-845	995	AUAGGGGUGAUCAGCUUGG	996	AuAGGGGUGAUcAGCUUGGdTsdT	antis

897-916	997	CACUCCCAAGGUGUGUGUC	998	cAcucccAAGGuGuGuGucdTsdT	sense

897-916	999	GACACACACCUUGGGAGUG	1000	GAcAcAcACCUUGGGAGUGdTsdT	antis

898-917	1001	ACUCCCAAGGUGUGUGUCA	1002	AcucccAAGGuGuGuGucAdTsdT	sense

898-917	1003	UGACACACACCUUGGGAGU	1004	UGAcAcAcACCUUGGGAGUdTsdT	antis

990-1009	1005	GCAAAGCAGCUGGUUCGGG	1006	GcAAAGcAGcuGGuucGGGdTsdT	sense

990-1009	1007	CCCGAACCAGCUGCUUUGC	1008	CCCGAACcAGCUGCUUUGCdTsdT	antis

992-1011	1009	AAAGCAGCUGGUUCGGGGG	1010	AAAGcAGcuGGuucGGGGGdTsdT	sense

992-1011	1011	CCCCCGAACCAGCUGCUUU	1012	CCCCCGAACcAGCUGCUUUdTsdT	antis

996-1015	1013	CAGCUGGUUCGGGGGGAGC	1014	cAGcuGGuucGGGGGGAGcdTsdT	sense

996-1015	1015	GCUCCCCCCGAACCAGCUG	1016	GCUCCCCCCGAACcAGCUGdTsdT	antis

1007-1026	1017	GGGGGAGCCCAAUGUGUCC	1018	GGGGGAGcccAAuGuGuccdTsdT	sense

1007-1026	1019	GGACACAUUGGGCUCCCCC	1020	GGAcAcAUUGGGCUCCCCCdTsdT	antis

1013-1032	1021	GCCCAAUGUGUCCUACAUC	1022	GcccAAuGuGuccuAcAucdTsdT	sense

1013-1032	1023	GAUGUAGGACACAUUGGGC	1024	GAUGuAGGAcAcAUUGGGCdTsdT	antis

1030-1049	1025	UCUGCUCUCGGUACUACCG	1026	ucuGcucucGGuAcuAccGdTsdT	sense

1030-1049	1027	CGGUAGUACCGAGAGCAGA	1028	CGGuAGuACCGAGAGcAGAdTsdT	antis

1104-1123	1029	UCGGCUGGCUGUGUACUUG	1030	ucGGcuGGcuGuGuAcuuGdTsdT	sense

1104-1123	1031	CAAGUACACAGCCAGCCGA	1032	cAAGuAcAcAGCcAGCCGAdTsdT	antis

1109-1128	1033	UGGCUGUGUACUUGCUGAG	1034	uGGcuGuGuAcuuGcuGAGdTsdT	sense

1109-1128	1035	CUCAGCAAGUACACAGCCA	1036	CUcAGcAAGuAcAcAGCcAdTsdT	antis

1120-1139	1037	UUGCUGAGCUACUUCUCGG	1038	uuGcuGAGcuAcuucucGGdTsdT	sense

1120-1139	1039	CCGAGAAGUAGCUCAGCAA	1040	CCGAGAAGuAGCUcAGcAAdTsdT	antis

1122-1141	1041	GCUGAGCUACUUCUCGGCC	1042	GcuGAGcuAcuucucGGccdTsdT	sense

1122-1141	1043	GGCCGAGAAGUAGCUCAGC	1044	GGCCGAGAAGuAGCUcAGCdTsdT	antis

1266-1285	1045	AUCAAAGCUCACCCUUGGA	1046	AucAAAGcucAcccuuGGAdTsdT	sense

1266-1285	1047	UCCAAGGGUGAGCUUUGAU	1048	UCcAAGGGUGAGCUUUGAUdTsdT	antis

1329-1348	1049	CUCUGCUCUAGCCUACUGG	1050	cucuGcucuAGccuAcuGGdTsdT	sense

1329-1348	1051	CCAGUAGGCUAGAGCAGAG	1052	CcAGuAGGCuAGAGcAGAGdTsdT	antis

1343-1362	1053	ACUGGAGUACACGCCAUCC	1054	AcuGGAGuAcAcGccAuccdTsdT	sense

1343-1362	1055	GGAUGGCGUGUACUCCAGU	1056	GGAUGGCGUGuACUCcAGUdTsdT	antis

1364-1383	1057	AAGGCUCUCCCCACUCGAG	1058	AAGGcucuccccAcucGAGdTsdT	sense

1364-1383	1059	CUCGAGUGGGGAGAGCCUU	1060	CUCGAGUGGGGAGAGCCUUdTsdT	antis

1411-1430	1061	UGCGGAGACUCGGAGCCCA	1062	uGcGGAGAcucGGAGcccAdTsdT	sense

1411-1430	1063	UGGGCUCCGAGUCUCCGCA	1064	UGGGCUCCGAGUCUCCGcAdTsdT	antis

1570-1589	1065	ACAACCCAUCCUCACAAGC	1066	AcAAcccAuccucAcAAGcdTsdT	sense

1570-1589	1067	GCUUGUGAGGAUGGGUUGU	1068	GCUUGUGAGGAUGGGUUGUdTsdT	antis

1589-1608	1069	UUUAACUGAAGCUCAGACU	1070	uuuAAcuGAAGcucAGAcudTsdT	sense

1589-1608	1071	AGUCUGAGCUUCAGUUAAA	1072	AGUCUGAGCUUcAGUuAAAdTsdT	antis

1609-1628	1073	GCCAAGAUUGGCAGCCAUC	1074	GccAAGAuuGGcAGccAucdTsdT	sense

1609-1628	1075	GAUGGCUGCCAAUCUUGGC	1076	GAUGGCUGCcAAUCUUGGCdTsdT	antis

1613-1632	1077	AGAUUGGCAGCCAUCUGAU	1078	AGAuuGGcAGccAucuGAudTsdT	sense

1613-1632	1079	AUCAGAUGGCUGCCAAUCU	1080	AUcAGAUGGCUGCcAAUCUdTsdT	antis

1615-1634	1081	AUUGGCAGCCAUCUGAUGC	1082	AuuGGcAGccAucuGAuGcdTsdT	sense

1615-1634	1083	GCAUCAGAUGGCUGCCAAU	1084	GcAUcAGAUGGCUGCcAAUdTsdT	antis

1809-1828	1085	UCCCUCAGCAGCCUAACCU	1086	ucccucAGcAGccuAAccudTsdT	sense

1809-1828	1087	AGGUUAGGCUGCUGAGGGA	1088	AGGUuAGGCUGCUGAGGGAdTsdT	antis

1844-1863	1089	AAAGAGGAUUUUAACUGUU	1090	AAAGAGGAuuuuAAcuGuudTsdT	sense

1844-1863	1091	AACAGUUAAAAUCCUCUUU	1092	AAcAGUuAAAAUCCUCUUUdTsdT	antis

1847-1866	1093	GAGGAUUUUAACUGUUUGU	1094	GAGGAuuuuAAcuGuuuGudTsdT	sense

1847-1866	1095	ACAAACAGUUAAAAUCCUC	1096	AcAAAcAGUuAAAAUCCUCdTsdT	antis

1853-1872	1097	UUUAACUGUUUGUAGGGGA	1098	uuuAAcuGuuuGuAGGGGAdTsdT	sense

1853-1872	1099	UCCCCUACAAACAGUUAAA	1100	UCCCCuAcAAAcAGUuAAAdTsdT	antis

1857-1876	1101	ACUGUUUGUAGGGGAGGGG	1102	AcuGuuuGuAGGGGAGGGGdTsdT	sense

1857-1876	1103	CCCCUCCCCUACAAACAGU	1104	CCCCUCCCCuAcAAAcAGUdTsdT	antis

1896-1915	1105	UGGGGGUGUGAGGACCUUC	1106	uGGGGGuGuGAGGAccuucdTsdT	sense

1896-1915	1107	GAAGGUCCUCACACCCCCA	1108	GAAGGUCCUcAcACCCCcAdTsdT	antis

1936-1955	1109	UCCCCCAGGCUACCACUCC	1110	ucccccAGGcuAccAcuccdTsdT	sense

1936-1955	1111	GGAGUGGUAGCCUGGGGGA	1112	GGAGUGGuAGCCUGGGGGAdTsdT	antis

1967-1986	1113	CUCUCCCAGGUCCCUUGUA	1114	cucucccAGGucccuuGuAdTsdT	sense

1967-1986	1115	UACAAGGGACCUGGGAGAG	1116	uAcAAGGGACCUGGGAGAGdTsdT	antis

1997-2016	1117	CCCAGCCCAUCUCUCGUCU	1118	cccAGcccAucucucGucudTsdT	sense

1997-2016	1119	AGACGAGAGAUGGGCUGGG	1120	AGACGAGAGAUGGGCUGGGdTsdT	antis

2001-2020	1121	GCCCAUCUCUCGUCUUCCC	1122	GcccAucucucGucuucccdTsdT	sense

2001-2020	1123	GGGAAGACGAGAGAUGGGC	1124	GGGAAGACGAGAGAUGGGCdTsdT	antis

2074-2093	1125	GUCAAUUCACACCAUUCAA	1126	GucAAuucAcAccAuucAAdTsdT	sense

2074-2093	1127	UUGAAUGGUGUGAAUUGAC	1128	UUGAAUGGUGUGAAUUGACdTsdT	antis

2093-2112	1129	CUUGCCCCCCCCAGCUGUA	1130	cuuGccccccccAGcuGuAdTsdT	sense

2093-2112	1131	UACAGCUGGGGGGGGCAAG	1132	uAcAGCUGGGGGGGGcAAGdTsdT	antis

2164-2183	1133	GAGGGGAGUAGAGAGAGUC	1134	GAGGGGAGuAGAGAGAGucdTsdT	sense

2164-2183	1135	GACUCUCUCUACUCCCCUC	1136	GACUCUCUCuACUCCCCUCdTsdT	antis

2168-2187	1137	GGAGUAGAGAGAGUCCCUG	1138	GGAGuAGAGAGAGucccuGdTsdT	sense

2168-2187	1139	CAGGGACUCUCUCUACUCC	1140	cAGGGACUCUCUCuACUCCdTsdT	antis

2185-2204	1141	UGGUGUCUUAGUUUCCACA	1142	uGGuGucuuAGuuuccAcAdTsdT	sense

2185-2204	1143	UGUGGAAACUAAGACACCA	1144	UGUGGAAACuAAGAcACcAdTsdT	antis

2191-2210	1145	CUUAGUUUCCACAGUAAGG	1146	cuuAGuuuccAcAGuAAGGdTsdT	sense

2191-2210	1147	CCUUACUGUGGAAACUAAG	1148	CCUuACUGUGGAAACuAAGdTsdT	antis

2202-2221	1149	CAGUAAGGUUUGCCUGUGU	1150	cAGuAAGGuuuGccuGuGudTsdT	sense

2202-2221	1151	ACACAGGCAAACCUUACUG	1152	AcAcAGGcAAACCUuACUGdTsdT	antis

2242-2261	1153	UAUUGGCAUGAAACCCUUA	1154	uAuuGGcAuGAAAcccuuAdTsdT	sense

2242-2261	1155	UAAGGGUUUCAUGCCAAUA	1156	uAAGGGUUUcAUGCcAAuAdTsdT	antis

388-407	1157	GGGGUGGCCCCAGCGGCAG	1158	GGGGuGGccccAGcGGcAGdTsdT	sense

388-407	1159	CUGCCGCUGGGGCCACCCC	1160	CUGCCGCUGGGGCcACCCCdTsdT	antis

425-444	1161	UGGCCCCGGCGCGGGCACU	1162	uGGccccGGcGcGGGcAcudTsdT	sense

425-444	1163	AGUGCCCGCGCCGGGGCCA	1164	AGUGCCCGCGCCGGGGCcAdTsdT	antis

2163-2182	1165	GGAGGGGAGUAGAGAGAGU	1166	GGAGGGGAGuAGAGAGAGudTsdT	sense

2163-2182	1167	ACUCUCUCUACUCCCCUCC	1168	ACUCUCUCuACUCCCCUCCdTsdT	antis

3-22	1169	GGUGACAACGAAGCCGACG	1170	GGuGAcAAcGAAGccGAcGdTsdT	sense

3-22	1171	CGUCGGCUUCGUUGUCACC	1172	CGUCGGCUUCGUUGUcACCdTsdT	antis

12-31	1173	GAAGCCGACGGCAGAGGGA	1174	GAAGccGAcGGcAGAGGGAdTsdT	sense

12-31	1175	UCCCUCUGCCGUCGGCUUC	1176	UCCCUCUGCCGUCGGCUUCdTsdT	antis

72-91	1177	GCCGGAGCCCGAACGGCGC	1178	GccGGAGcccGAAcGGcGcdTsdT	sense

72-91	1179	GCGCCGUUCGGGCUCCGGC	1180	GCGCCGUUCGGGCUCCGGCdTsdT	antis

90-109	1181	CGGCCUGGAAGAGGCCGGA	1182	cGGccuGGAAGAGGccGGAdTsdT	sense

90-109	1183	UCCGGCCUCUUCCAGGCCG	1184	UCCGGCCUCUUCcAGGCCGdTsdT	antis

316-335	1185	GCCCAGGAGGCACUGGCGG	1186	GcccAGGAGGcAcuGGcGGdTsdT	sense

316-335	1187	CCGCCAGUGCCUCCUGGGC	1188	CCGCcAGUGCCUCCUGGGCdTsdT	antis

335-354	1189	CGGGAAAGCGUCAGUCGGG	1190	cGGGAAAGcGucAGucGGGdTsdT	sense

335-354	1191	CCCGACUGACGCUUUCCCG	1192	CCCGACUGACGCUUUCCCGdTsdT	antis

466-485	1193	AGCUGGGCCGUGACAGCGG	1194	AGcuGGGccGuGAcAGcGGdTsdT	sense

466-485	1195	CCGCUGUCACGGCCCAGCU	1196	CCGCUGUcACGGCCcAGCUdTsdT	antis

489-508	1197	GUGACCACAGUGGUAGCCA	1198	GuGAccAcAGuGGuAGccAdTsdT	sense

489-508	1199	UGGCUACCACUGUGGUCAC	1200	UGGCuACcACUGUGGUcACdTsdT	antis

708-727	1201	GUGAGGCUGCGGUACUUUU	1202	GuGAGGcuGcGGuAcuuuudTsdT	sense

708-727	1203	AAAAGUACCGCAGCCUCAC	1204	AAAAGuACCGcAGCCUcACdTsdT	antis

1098-1117	1205	GUGUGGUCGGCUGGCUGUG	1206	GuGuGGucGGcuGGcuGuGdTsdT	sense

1098-1117	1207	CACAGCCAGCCGACCACAC	1208	cAcAGCcAGCCGACcAcACdTsdT	antis

1117-1136	1209	UACUUGCUGAGCUACUUCU	1210	uAcuuGcuGAGcuAcuucudTsdT	sense

1117-1136	1211	AGAAGUAGCUCAGCAAGUA	1212	AGAAGuAGCUcAGcAAGuAdTsdT	antis

1305-1324	1213	AAGACACCACCUGAGGCCA	1214	AAGAcAccAccuGAGGccAdTsdT	sense

1305-1324	1215	UGGCCUCAGGUGGUGUCUU	1216	UGGCCUcAGGUGGUGUCUUdTsdT	antis

1341-1360	1217	CUACUGGAGUACACGCCAU	1218	cuAcuGGAGuAcAcGccAudTsdT	sense

1341-1360	1219	AUGGCGUGUACUCCAGUAG	1220	AUGGCGUGuACUCcAGuAGdTsdT	antis

1345-1364	1221	UGGAGUACACGCCAUCCUC	1222	uGGAGuAcAcGccAuccucdTsdT	sense

1345-1364	1223	GAGGAUGGCGUGUACUCCA	1224	GAGGAUGGCGUGuACUCcAdTsdT	antis

1811-1830	1225	CCUCAGCAGCCUAACCUCU	1226	ccucAGcAGccuAAccucudTsdT	sense

1811-1830	1227	AGAGGUUAGGCUGCUGAGG	1228	AGAGGUuAGGCUGCUGAGGdTsdT	antis

1850-1869	1229	GAUUUUAACUGUUUGUAGG	1230	GAuuuuAAcuGuuuGuAGGdTsdT	sense

1850-1869	1231	CCUACAAACAGUUAAAAUC	1232	CCuAcAAAcAGUuAAAAUCdTsdT	antis

1969-1988	1233	CUCCCAGGUCCCUUGUAAA	1234	cucccAGGucccuuGuAAAdTsdT	sense

1969-1988	1235	UUUACAAGGGACCUGGGAG	1236	UUuAcAAGGGACCUGGGAGdTsdT	antis

2162-2181	1237	AGGAGGGGAGUAGAGAGAG	1238	AGGAGGGGAGuAGAGAGAGdTsdT	sense

2162-2181	1239	CUCUCUCUACUCCCCUCCU	1240	CUCUCUCuACUCCCCUCCUdTsdT	antis

2195-2214	1241	GUUUCCACAGUAAGGUUUG	1242	GuuuccAcAGuAAGGuuuGdTsdT	sense

2195-2214	1243	CAAACCUUACUGUGGAAAC	1244	cAAACCUuACUGUGGAAACdTsdT	antis

1239-1258	1245	AACUAUACGGAGUUCAAGU	1246	AAcuAuAcGGAGuucAAGudTsdT	sense

1239-1258	1247	ACUUGAACUCCGUAUAGUU	1248	ACUUGAACUCCGuAuAGUUdTsdT	antis

1240-1259	1249	ACUAUACGGAGUUCAAGUU	1250	AcuAuAcGGAGuucAAGuudTsdT	sense

1240-1259	1251	AACUUGAACUCCGUAUAGU	1252	AACUUGAACUCCGuAuAGUdTsdT	antis

80-99	1253	CCGAACGGCGCGGCCUGGA	1254	ccGAAcGGcGcGGccuGGAdTsdT	sense

80-99	1255	UCCAGGCCGCGCCGUUCGG	1256	UCcAGGCCGCGCCGUUCGGdTsdT	antis

745-764	1257	AGAAGGACGAGCUGUAUUU	1258	AGAAGGAcGAGcuGuAuuudTsdT	sense

745-764	1259	AAAUACAGCUCGUCCUUCU	1260	AAAuAcAGCUCGUCCUUCUdTsdT	antis

1078-1097	1261	AUUACACCUCGUCCAUCGA	1262	AuuAcAccucGuccAucGAdTsdT	sense

1078-1097	1263	UCGAUGGACGAGGUGUAAU	1264	UCGAUGGACGAGGUGuAAUdTsdT	antis

2071-2090	1265	AACGUCAAUUCACACCAUU	1266	AAcGucAAuucAcAccAuudTsdT	sense

2071-2090	1267	AAUGGUGUGAAUUGACGUU	1268	AAUGGUGUGAAUUGACGUUdTsdT	antis

15-34	1269	GCCGACGGCAGAGGGACUU	1270	GccGAcGGcAGAGGGAcuudTsdT	sense

15-34	1271	AAGUCCCUCUGCCGUCGGC	1272	AAGUCCCUCUGCCGUCGGCdTsdT	antis

77-96	1273	AGCCCGAACGGCGCGGCCU	1274	AGcccGAAcGGcGcGGccudTsdT	sense

77-96	1275	AGGCCGCGCCGUUCGGGCU	1276	AGGCCGCGCCGUUCGGGCUdTsdT	antis

182-201	1277	GCUCGGCGCCAUGAGCGGC	1278	GcucGGcGccAuGAGcGGcdTsdT	sense

182-201	1279	GCCGCUCAUGGCGCCGAGC	1280	GCCGCUcAUGGCGCCGAGCdTsdT	antis

659-678	1281	CAAGAACCGAGAACUGCAG	1282	cAAGAAccGAGAAcuGcAGdTsdT	sense

659-678	1283	CUGCAGUUCUCGGUUCUUG	1284	CUGcAGUUCUCGGUUCUUGdTsdT	antis

788-807	1285	CGAGACGGUGUACCGAGUG	1286	cGAGAcGGuGuAccGAGuGdTsdT	sense

788-807	1287	CACUCGGUACACCGUCUCG	1288	cACUCGGuAcACCGUCUCGdTsdT	antis

1002-1021	1289	GUUCGGGGGGAGCCCAAUG	1290	GuucGGGGGGAGcccAAuGdTsdT	sense

1002-1021	1291	CAUUGGGCUCCCCCCGAAC	1292	cAUUGGGCUCCCCCCGAACdTsdT	antis

1333-1352	1293	GCUCUAGCCUACUGGAGUA	1294	GcucuAGccuAcuGGAGuAdTsdT	sense

1333-1352	1295	UACUCCAGUAGGCUAGAGC	1296	uACUCcAGuAGGCuAGAGCdTsdT	antis

1435-1454	1297	CCAACGACCGCCCGCUUCC	1298	ccAAcGAccGcccGcuuccdTsdT	sense

1435-1454	1299	GGAAGCGGGCGGUCGUUGG	1300	GGAAGCGGGCGGUCGUUGGdTsdT	antis

2246-2265	1301	GGCAUGAAACCCUUAAAAA	1302	GGcAuGAAAcccuuAAAAAdTsdT	sense

2246-2265	1303	UUUUUAAGGGUUUCAUGCC	1304	UUUUuAAGGGUUUcAUGCCdTsdT	antis

14-33	1305	AGCCGACGGCAGAGGGACU	1306	AGccGAcGGcAGAGGGAcudTsdT	sense

14-33	1307	AGUCCCUCUGCCGUCGGCU	1308	AGUCCCUCUGCCGUCGGCUdTsdT	antis

17-36	1309	CGACGGCAGAGGGACUUCA	1310	cGAcGGcAGAGGGAcuucAdTsdT	sense

17-36	1311	UGAAGUCCCUCUGCCGUCG	1312	UGAAGUCCCUCUGCCGUCGdTsdT	antis

18-37	1313	GACGGCAGAGGGACUUCAU	1314	GAcGGcAGAGGGAcuucAudTsdT	sense

18-37	1315	AUGAAGUCCCUCUGCCGUC	1316	AUGAAGUCCCUCUGCCGUCdTsdT	antis

78-97	1317	GCCCGAACGGCGCGGCCUG	1318	GcccGAAcGGcGcGGccuGdTsdT	sense

78-97	1319	CAGGCCGCGCCGUUCGGGC	1320	cAGGCCGCGCCGUUCGGGCdTsdT	antis

81-100	1321	CGAACGGCGCGGCCUGGAA	1322	cGAAcGGcGcGGccuGGAAdTsdT	sense

81-100	1323	UUCCAGGCCGCGCCGUUCG	1324	UUCcAGGCCGCGCCGUUCGdTsdT	antis

83-102	1325	AACGGCGCGGCCUGGAAGA	1326	AAcGGcGcGGccuGGAAGAdTsdT	sense

83-102	1327	UCUUCCAGGCCGCGCCGUU	1328	UCUUCcAGGCCGCGCCGUUdTsdT	antis

87-106	1329	GCGCGGCCUGGAAGAGGCC	1330	GcGcGGccuGGAAGAGGccdTsdT	sense

87-106	1331	GGCCUCUUCCAGGCCGCGC	1332	GGCCUCUUCcAGGCCGCGCdTsdT	antis

181-200	1333	CGCUCGGCGCCAUGAGCGG	1334	cGcucGGcGccAuGAGcGGdTsdT	sense

181-200	1335	CCGCUCAUGGCGCCGAGCG	1336	CCGCUcAUGGCGCCGAGCGdTsdT	antis

183-202	1337	CUCGGCGCCAUGAGCGGCG	1338	cucGGcGccAuGAGcGGcGdTsdT	sense

183-202	1339	CGCCGCUCAUGGCGCCGAG	1340	CGCCGCUcAUGGCGCCGAGdTsdT	antis

189-208	1341	GCCAUGAGCGGCGGCGGGC	1342	GccAuGAGcGGcGGcGGGcdTsdT	sense

189-208	1343	GCCCGCCGCCGCUCAUGGC	1344	GCCCGCCGCCGCUcAUGGCdTsdT	antis

191-210	1345	CAUGAGCGGCGGCGGGCCU	1346	cAuGAGcGGcGGcGGGccudTsdT	sense

191-210	1347	AGGCCCGCCGCCGCUCAUG	1348	AGGCCCGCCGCCGCUcAUGdTsdT	antis

254-273	1349	GUUCGCGGAGCCAGGAGGC	1350	GuucGcGGAGccAGGAGGcdTsdT	sense

254-273	1351	GCCUCCUGGCUCCGCGAAC	1352	GCCUCCUGGCUCCGCGAACdTsdT	antis

255-274	1353	UUCGCGGAGCCAGGAGGCG	1354	uucGcGGAGccAGGAGGcGdTsdT	sense

255-274	1355	CGCCUCCUGGCUCCGCGAA	1356	CGCCUCCUGGCUCCGCGAAdTsdT	antis

431-450	1357	CGGCGCGGGCACUAGCUUC	1358	cGGcGcGGGcAcuAGcuucdTsdT	sense

431-450	1359	GAAGCUAGUGCCCGCGCCG	1360	GAAGCuAGUGCCCGCGCCGdTsdT	antis

433-452	1361	GCGCGGGCACUAGCUUCCC	1362	GcGcGGGcAcuAGcuucccdTsdT	sense

433-452	1363	GGGAAGCUAGUGCCCGCGC	1364	GGGAAGCuAGUGCCCGCGCdTsdT	antis

441-460	1365	ACUAGCUUCCCGCCGCCGG	1366	AcuAGcuucccGccGccGGdTsdT	sense

441-460	1367	CCGGCGGCGGGAAGCUAGU	1368	CCGGCGGCGGGAAGCuAGUdTsdT	antis

442-461	1369	CUAGCUUCCCGCCGCCGGG	1370	cuAGcuucccGccGccGGGdTsdT	sense

442-461	1371	CCCGGCGGCGGGAAGCUAG	1372	CCCGGCGGCGGGAAGCuAGdTsdT	antis

446-465	1373	CUUCCCGCCGCCGGGAGUG	1374	cuucccGccGccGGGAGuGdTsdT	sense

446-465	1375	CACUCCCGGCGGCGGGAAG	1376	cACUCCCGGCGGCGGGAAGdTsdT	antis

473-492	1377	CCGUGACAGCGGGAAGGUG	1378	ccGuGAcAGcGGGAAGGuGdTsdT	sense

473-492	1379	CACCUUCCCGCUGUCACGG	1380	cACCUUCCCGCUGUcACGGdTsdT	antis

532-551	1381	CCCAAGAAGUGGCUUACAC	1382	cccAAGAAGuGGcuuAcAcdTsdT	sense

532-551	1383	GUGUAAGCCACUUCUUGGG	1384	GUGuAAGCcACUUCUUGGGdTsdT	antis

580-599	1385	UCGGAGUAGUAUACCAGGC	1386	ucGGAGuAGuAuAccAGGcdTsdT	sense

580-599	1387	GCCUGGUAUACUACUCCGA	1388	GCCUGGuAuACuACUCCGAdTsdT	antis

589-608	1389	UAUACCAGGCACGGCUGGC	1390	uAuAccAGGcAcGGcuGGcdTsdT	sense

589-608	1391	GCCAGCCGUGCCUGGUAUA	1392	GCcAGCCGUGCCUGGuAuAdTsdT	antis

598-617	1393	CACGGCUGGCAGAGACGAG	1394	cAcGGcuGGcAGAGAcGAGdTsdT	sense

598-617	1395	CUCGUCUCUGCCAGCCGUG	1396	CUCGUCUCUGCcAGCCGUGdTsdT	antis

837-856	1397	ACCCCUAUCAUCUACAUCA	1398	AccccuAucAucuAcAucAdTsdT	sense

837-856	1399	UGAUGUAGAUGAUAGGGGU	1400	UGAUGuAGAUGAuAGGGGUdTsdT	antis

838-857	1401	CCCCUAUCAUCUACAUCAA	1402	ccccuAucAucuAcAucAAdTsdT	sense

838-857	1403	UUGAUGUAGAUGAUAGGGG	1404	UUGAUGuAGAUGAuAGGGGdTsdT	antis

839-858	1405	CCCUAUCAUCUACAUCAAG	1406	cccuAucAucuAcAucAAGdTsdT	sense

839-858	1407	CUUGAUGUAGAUGAUAGGG	1408	CUUGAUGuAGAUGAuAGGGdTsdT	antis

922-941	1409	ACAUCAAGCCCCAGAAUUU	1410	AcAucAAGccccAGAAuuudTsdT	sense

922-941	1411	AAAUUCUGGGGCUUGAUGU	1412	AAAUUCUGGGGCUUGAUGUdTsdT	antis

923-942	1413	CAUCAAGCCCCAGAAUUUG	1414	cAucAAGccccAGAAuuuGdTsdT	sense

923-942	1415	CAAAUUCUGGGGCUUGAUG	1416	cAAAUUCUGGGGCUUGAUGdTsdT	antis

1012-1031	1417	AGCCCAAUGUGUCCUACAU	1418	AGcccAAuGuGuccuAcAudTsdT	sense

1012-1031	1419	AUGUAGGACACAUUGGGCU	1420	AUGuAGGAcAcAUUGGGCUdTsdT	antis

1014-1033	1421	CCCAAUGUGUCCUACAUCU	1422	cccAAuGuGuccuAcAucudTsdT	sense

1014-1033	1423	AGAUGUAGGACACAUUGGG	1424	AGAUGuAGGAcAcAUUGGGdTsdT	antis

1046-1065	1425	CCGUGCUCCAGAACUCAUC	1426	ccGuGcuccAGAAcucAucdTsdT	sense

1046-1065	1427	GAUGAGUUCUGGAGCACGG	1428	GAUGAGUUCUGGAGcACGGdTsdT	antis

1056-1075	1429	GAACUCAUCUUUGGAGCCA	1430	GAAcucAucuuuGGAGccAdTsdT	sense

1056-1075	1431	UGGCUCCAAAGAUGAGUUC	1432	UGGCUCcAAAGAUGAGUUCdTsdT	antis

1088-1107	1433	GUCCAUCGAUGUGUGGUCG	1434	GuccAucGAuGuGuGGucGdTsdT	sense

1088-1107	1435	CGACCACACAUCGAUGGAC	1436	CGACcAcAcAUCGAUGGACdTsdT	antis

1123-1142	1437	CUGAGCUACUUCUCGGCCA	1438	cuGAGcuAcuucucGGccAdTsdT	sense

1123-1142	1439	UGGCCGAGAAGUAGCUCAG	1440	UGGCCGAGAAGuAGCUcAGdTsdT	antis

1232-1251	1441	GAACCCUAACUAUACGGAG	1442	GAAcccuAAcuAuAcGGAGdTsdT	sense

1232-1251	1443	CUCCGUAUAGUUAGGGUUC	1444	CUCCGuAuAGUuAGGGUUCdTsdT	antis

1287-1306	1445	AAGGUGUUCAAAUCUUCAA	1446	AAGGuGuucAAAucuucAAdTsdT	sense

1287-1306	1447	UUGAAGAUUUGAACACCUU	1448	UUGAAGAUUUGAAcACCUUdTsdT	antis

1319-1338	1449	GGCCAUUGCACUCUGCUCU	1450	GGccAuuGcAcucuGcucudTsdT	sense

1319-1338	1451	AGAGCAGAGUGCAAUGGCC	1452	AGAGcAGAGUGcAAUGGCCdTsdT	antis

1349-1368	1453	GUACACGCCAUCCUCAAGG	1454	GuAcAcGccAuccucAAGGdTsdT	sense

1349-1368	1455	CCUUGAGGAUGGCGUGUAC	1456	CCUUGAGGAUGGCGUGuACdTsdT	antis

1409-1428	1457	ACUGCGGAGACUCGGAGCC	1458	AcuGcGGAGAcucGGAGccdTsdT	sense

1409-1428	1459	GGCUCCGAGUCUCCGCAGU	1460	GGCUCCGAGUCUCCGcAGUdTsdT	antis

1410-1429	1461	CUGCGGAGACUCGGAGCCC	1462	cuGcGGAGAcucGGAGcccdTsdT	sense

1410-1429	1463	GGGCUCCGAGUCUCCGCAG	1464	GGGCUCCGAGUCUCCGcAGdTsdT	antis

1448-1467	1465	GCUUCCCCCCCUGUUCAAC	1466	GcuucccccccuGuucAAcdTsdT	sense

1448-1467	1467	GUUGAACAGGGGGGGAAGC	1468	GUUGAAcAGGGGGGGAAGCdTsdT	antis

1449-1468	1469	CUUCCCCCCCUGUUCAACU	1470	cuucccccccuGuucAAcudTsdT	sense

1449-1468	1471	AGUUGAACAGGGGGGGAAG	1472	AGUUGAAcAGGGGGGGAAGdTsdT	antis

1450-1469	1473	UUCCCCCCCUGUUCAACUU	1474	uucccccccuGuucAAcuudTsdT	sense

1450-1469	1475	AAGUUGAACAGGGGGGGAA	1476	AAGUUGAAcAGGGGGGGAAdTsdT	antis

1567-1586	1477	CCUACAACCCAUCCUCACA	1478	ccuAcAAcccAuccucAcAdTsdT	sense

1567-1586	1479	UGUGAGGAUGGGUUGUAGG	1480	UGUGAGGAUGGGUUGuAGGdTsdT	antis

1583-1602	1481	ACAAGCUUUAACUGAAGCU	1482	AcAAGcuuuAAcuGAAGcudTsdT	sense

1583-1602	1483	AGCUUCAGUUAAAGCUUGU	1484	AGCUUcAGUuAAAGCUUGUdTsdT	antis

1596-1615	1485	GAAGCUCAGACUGGCCAAG	1486	GAAGcucAGAcuGGccAAGdTsdT	sense

1596-1615	1487	CUUGGCCAGUCUGAGCUUC	1488	CUUGGCcAGUCUGAGCUUCdTsdT	antis

1608-1627	1489	GGCCAAGAUUGGCAGCCAU	1490	GGccAAGAuuGGcAGccAudTsdT	sense

1608-1627	1491	AUGGCUGCCAAUCUUGGCC	1492	AUGGCUGCcAAUCUUGGCCdTsdT	antis

1638-1657	1493	ACUGCUACCCUCGCUAGCU	1494	AcuGcuAcccucGcuAGcudTsdT	sense

1638-1657	1495	AGCUAGCGAGGGUAGCAGU	1496	AGCuAGCGAGGGuAGcAGUdTsdT	antis

1854-1873	1497	UUAACUGUUUGUAGGGGAG	1498	uuAAcuGuuuGuAGGGGAGdTsdT	sense

1854-1873	1499	CUCCCCUACAAACAGUUAA	1500	CUCCCCuAcAAAcAGUuAAdTsdT	antis

1980-1999	1501	CUUGUAAAUAGAACCAGCC	1502	cuuGuAAAuAGAAccAGccdTsdT	sense

1980-1999	1503	GGCUGGUUCUAUUUACAAG	1504	GGCUGGUUCuAUUuAcAAGdTsdT	antis

2034-2053	1505	GGGUGUAAAUAGAUUGUUA	1506	GGGuGuAAAuAGAuuGuuAdTsdT	sense

2034-2053	1507	UAACAAUCUAUUUACACCC	1508	uAAcAAUCuAUUuAcACCCdTsdT	antis

2037-2056	1509	UGUAAAUAGAUUGUUAUAA	1510	uGuAAAuAGAuuGuuAuAAdTsdT	sense

2037-2056	1511	UUAUAACAAUCUAUUUACA	1512	UuAuAAcAAUCuAUUuAcAdTsdT	antis

2087-2106	1513	AUUCAACUUGCCCCCCCCA	1514	AuucAAcuuGccccccccAdTsdT	sense

2087-2106	1515	UGGGGGGGGCAAGUUGAAU	1516	UGGGGGGGGcAAGUUGAAUdTsdT	antis

2088-2107	1517	UUCAACUUGCCCCCCCCAG	1518	uucAAcuuGccccccccAGdTsdT	sense

2088-2107	1519	CUGGGGGGGGCAAGUUGAA	1520	CUGGGGGGGGcAAGUUGAAdTsdT	antis

2171-2190	1521	GUAGAGAGAGUCCCUGGUG	1522	GuAGAGAGAGucccuGGuGdTsdT	sense

2171-2190	1523	CACCAGGGACUCUCUCUAC	1524	cACcAGGGACUCUCUCuACdTsdT	antis

2212-2231	1525	UGCCUGUGUACAGACCUCU	1526	uGccuGuGuAcAGAccucudTsdT	sense

2212-2231	1527	AGAGGUCUGUACACAGGCA	1528	AGAGGUCUGuAcAcAGGcAdTsdT	antis

2221-2240	1529	ACAGACCUCUGUUCAAUAA	1530	AcAGAccucuGuucAAuAAdTsdT	sense

2221-2240	1531	UUAUUGAACAGAGGUCUGU	1532	UuAUUGAAcAGAGGUCUGUdTsdT	antis

190-209	1533	CCAUGAGCGGCGGCGGGCC	1534	ccAuGAGcGGcGGcGGGccdTsdT	sense

190-209	1535	GGCCCGCCGCCGCUCAUGG	1536	GGCCCGCCGCCGCUcAUGGdTsdT	antis

377-396	1537	CUCGAGCUCCGGGGGUGGC	1538	cucGAGcuccGGGGGuGGcdTsdT	sense

377-396	1539	GCCACCCCCGGAGCUCGAG	1540	GCcACCCCCGGAGCUCGAGdTsdT	antis

469-488	1541	UGGGCCGUGACAGCGGGAA	1542	uGGGccGuGAcAGcGGGAAdTsdT	sense

469-488	1543	UUCCCGCUGUCACGGCCCA	1544	UUCCCGCUGUcACGGCCcAdTsdT	antis

590-609	1545	AUACCAGGCACGGCUGGCA	1546	AuAccAGGcAcGGcuGGcAdTsdT	sense

590-609	1547	UGCCAGCCGUGCCUGGUAU	1548	UGCcAGCCGUGCCUGGuAUdTsdT	antis

658-677	1549	UCAAGAACCGAGAACUGCA	1550	ucAAGAAccGAGAAcuGcAdTsdT	sense

658-677	1551	UGCAGUUCUCGGUUCUUGA	1552	UGcAGUUCUCGGUUCUUGAdTsdT	antis

998-1017	1553	GCUGGUUCGGGGGGAGCCC	1554	GcuGGuucGGGGGGAGcccdTsdT	sense

998-1017	1555	GGGCUCCCCCCGAACCAGC	1556	GGGCUCCCCCCGAACcAGCdTsdT	antis

999-1018	1557	CUGGUUCGGGGGGAGCCCA	1558	cuGGuucGGGGGGAGcccAdTsdT	sense

999-1018	1559	UGGGCUCCCCCCGAACCAG	1560	UGGGCUCCCCCCGAACcAGdTsdT	antis

1025-1044	1561	CUACAUCUGCUCUCGGUAC	1562	cuAcAucuGcucucGGuAcdTsdT	sense

1025-1044	1563	GUACCGAGAGCAGAUGUAG	1564	GuACCGAGAGcAGAUGuAGdTsdT	antis

1327-1346	1565	CACUCUGCUCUAGCCUACU	1566	cAcucuGcucuAGccuAcudTsdT	sense

1327-1346	1567	AGUAGGCUAGAGCAGAGUG	1568	AGuAGGCuAGAGcAGAGUGdTsdT	antis

1417-1436	1569	GACUCGGAGCCCAGCUCCC	1570	GAcucGGAGcccAGcucccdTsdT	sense

1417-1436	1571	GGGAGCUGGGCUCCGAGUC	1572	GGGAGCUGGGCUCCGAGUCdTsdT	antis

1594-1613	1573	CUGAAGCUCAGACUGGCCA	1574	cuGAAGcucAGAcuGGccAdTsdT	sense

1594-1613	1575	UGGCCAGUCUGAGCUUCAG	1576	UGGCcAGUCUGAGCUUcAGdTsdT	antis

2213-2232	1577	GCCUGUGUACAGACCUCUG	1578	GccuGuGuAcAGAccucuGdTsdT	sense

2213-2232	1579	CAGAGGUCUGUACACAGGC	1580	cAGAGGUCUGuAcAcAGGCdTsdT	antis

1451-1470	1581	UCCCCCCCUGUUCAACUUC	1582	ucccccccuGuucAAcuucdTsdT	sense

1451-1470	1583	GAAGUUGAACAGGGGGGGA	1584	GAAGUUGAAcAGGGGGGGAdTsdT	antis

1563-1582	1585	ACUUCCUACAACCCAUCCU	1586	AcuuccuAcAAcccAuccudTsdT	sense

1563-1582	1587	AGGAUGGGUUGUAGGAAGU	1588	AGGAUGGGUUGuAGGAAGUdTsdT	antis

1607-1626	1589	UGGCCAAGAUUGGCAGCCA	1590	uGGccAAGAuuGGcAGccAdTsdT	sense

1607-1626	1591	UGGCUGCCAAUCUUGGCCA	1592	UGGCUGCcAAUCUUGGCcAdTsdT	antis

1939-1958	1593	CCCAGGCUACCACUCCUUC	1594	cccAGGcuAccAcuccuucdTsdT	sense

1939-1958	1595	GAAGGAGUGGUAGCCUGGG	1596	GAAGGAGUGGuAGCCUGGGdTsdT	antis

74-93	1597	CGGAGCCCGAACGGCGCGG	1598	cGGAGcccGAAcGGcGcGGdTsdT	sense

74-93	1599	CCGCGCCGUUCGGGCUCCG	1600	CCGCGCCGUUCGGGCUCCGdTsdT	antis

75-94	1601	GGAGCCCGAACGGCGCGGC	1602	GGAGcccGAAcGGcGcGGcdTsdT	sense

75-94	1603	GCCGCGCCGUUCGGGCUCC	1604	GCCGCGCCGUUCGGGCUCCdTsdT	antis

85-104	1605	CGGCGCGGCCUGGAAGAGG	1606	cGGcGcGGccuGGAAGAGGdTsdT	sense

85-104	1607	CCUCUUCCAGGCCGCGCCG	1608	CCUCUUCcAGGCCGCGCCGdTsdT	antis

86-105	1609	GGCGCGGCCUGGAAGAGGC	1610	GGcGcGGccuGGAAGAGGcdTsdT	sense

86-105	1611	GCCUCUUCCAGGCCGCGCC	1612	GCCUCUUCcAGGCCGCGCCdTsdT	antis

203-222	1613	CGGGCCUUCGGGAGGCGGC	1614	cGGGccuucGGGAGGcGGcdTsdT	sense

203-222	1615	GCCGCCUCCCGAAGGCCCG	1616	GCCGCCUCCCGAAGGCCCGdTsdT	antis

206-225	1617	GCCUUCGGGAGGCGGCCCU	1618	GccuucGGGAGGcGGcccudTsdT	sense

206-225	1619	AGGGCCGCCUCCCGAAGGC	1620	AGGGCCGCCUCCCGAAGGCdTsdT	antis

208-227	1621	CUUCGGGAGGCGGCCCUGG	1622	cuucGGGAGGcGGcccuGGdTsdT	sense

208-227	1623	CCAGGGCCGCCUCCCGAAG	1624	CcAGGGCCGCCUCCCGAAGdTsdT	antis

245-264	1625	GACCAGCUCGUUCGCGGAG	1626	GAccAGcucGuucGcGGAGdTsdT	sense

245-264	1627	CUCCGCGAACGAGCUGGUC	1628	CUCCGCGAACGAGCUGGUCdTsdT	antis

448-467	1629	UCCCGCCGCCGGGAGUGAA	1630	ucccGccGccGGGAGuGAAdTsdT	sense

448-467	1631	UUCACUCCCGGCGGCGGGA	1632	UUcACUCCCGGCGGCGGGAdTsdT	antis

452-471	1633	GCCGCCGGGAGUGAAGCUG	1634	GccGccGGGAGuGAAGcuGdTsdT	sense

452-471	1635	CAGCUUCACUCCCGGCGGC	1636	cAGCUUcACUCCCGGCGGCdTsdT	antis

453-472	1637	CCGCCGGGAGUGAAGCUGG	1638	ccGccGGGAGuGAAGcuGGdTsdT	sense

453-472	1639	CCAGCUUCACUCCCGGCGG	1640	CcAGCUUcACUCCCGGCGGdTsdT	antis

470-489	1641	GGGCCGUGACAGCGGGAAG	1642	GGGccGuGAcAGcGGGAAGdTsdT	sense

470-489	1643	CUUCCCGCUGUCACGGCCC	1644	CUUCCCGCUGUcACGGCCCdTsdT	antis

588-607	1645	GUAUACCAGGCACGGCUGG	1646	GuAuAccAGGcAcGGcuGGdTsdT	sense

588-607	1647	CCAGCCGUGCCUGGUAUAC	1648	CcAGCCGUGCCUGGuAuACdTsdT	antis

609-628	1649	GAGACGAGGGAACUGGUGG	1650	GAGAcGAGGGAAcuGGuGGdTsdT	sense

609-628	1651	CCACCAGUUCCCUCGUCUC	1652	CcACcAGUUCCCUCGUCUCdTsdT	antis

611-630	1653	GACGAGGGAACUGGUGGCC	1654	GAcGAGGGAAcuGGuGGccdTsdT	sense

611-630	1655	GGCCACCAGUUCCCUCGUC	1656	GGCcACcAGUUCCCUCGUCdTsdT	antis

649-668	1657	ACAAAAGGUUCAAGAACCG	1658	AcAAAAGGuucAAGAAccGdTsdT	sense

649-668	1659	CGGUUCUUGAACCUUUUGU	1660	CGGUUCUUGAACCUUUUGUdTsdT	antis

652-671	1661	AAAGGUUCAAGAACCGAGA	1662	AAAGGuucAAGAAccGAGAdTsdT	sense

652-671	1663	UCUCGGUUCUUGAACCUUU	1664	UCUCGGUUCUUGAACCUUUdTsdT	antis

653-672	1665	AAGGUUCAAGAACCGAGAA	1666	AAGGuucAAGAAccGAGAAdTsdT	sense

653-672	1667	UUCUCGGUUCUUGAACCUU	1668	UUCUCGGUUCUUGAACCUUdTsdT	antis

742-761	1669	AGAAGAAGGACGAGCUGUA	1670	AGAAGAAGGAcGAGcuGuAdTsdT	sense

742-761	1671	UACAGCUCGUCCUUCUUCU	1672	uAcAGCUCGUCCUUCUUCUdTsdT	antis

744-763	1673	AAGAAGGACGAGCUGUAUU	1674	AAGAAGGAcGAGcuGuAuudTsdT	sense

744-763	1675	AAUACAGCUCGUCCUUCUU	1676	AAuAcAGCUCGUCCUUCUUdTsdT	antis

790-809	1677	AGACGGUGUACCGAGUGGC	1678	AGAcGGuGuAccGAGuGGcdTsdT	sense

790-809	1679	GCCACUCGGUACACCGUCU	1680	GCcACUCGGuAcACCGUCUdTsdT	antis

840-859	1681	CCUAUCAUCUACAUCAAGG	1682	ccuAucAucuAcAucAAGGdTsdT	sense

840-859	1683	CCUUGAUGUAGAUGAUAGG	1684	CCUUGAUGuAGAUGAuAGGdTsdT	antis

882-901	1685	AGCUUGGCCUACAUCCACU	1686	AGcuuGGccuAcAuccAcudTsdT	sense

882-901	1687	AGUGGAUGUAGGCCAAGCU	1688	AGUGGAUGuAGGCcAAGCUdTsdT	antis

912-931	1689	UGUCACCGUGACAUCAAGC	1690	uGucAccGuGAcAucAAGcdTsdT	sense

912-931	1691	GCUUGAUGUCACGGUGACA	1692	GCUUGAUGUcACGGUGAcAdTsdT	antis

947-966	1693	GGACCCUGACACUGCUGUC	1694	GGAcccuGAcAcuGcuGucdTsdT	sense

947-966	1695	GACAGCAGUGUCAGGGUCC	1696	GAcAGcAGUGUcAGGGUCCdTsdT	antis

1009-1028	1697	GGGAGCCCAAUGUGUCCUA	1698	GGGAGcccAAuGuGuccuAdTsdT	sense

1009-1028	1699	UAGGACACAUUGGGCUCCC	1700	uAGGAcAcAUUGGGCUCCCdTsdT	antis

1017-1036	1701	AAUGUGUCCUACAUCUGCU	1702	AAuGuGuccuAcAucuGcudTsdT	sense

1017-1036	1703	AGCAGAUGUAGGACACAUU	1704	AGcAGAUGuAGGAcAcAUUdTsdT	antis

1113-1132	1705	UGUGUACUUGCUGAGCUAC	1706	uGuGuAcuuGcuGAGcuAcdTsdT	sense

1113-1132	1707	GUAGCUCAGCAAGUACACA	1708	GuAGCUcAGcAAGuAcAcAdTsdT	antis

1121-1140	1709	UGCUGAGCUACUUCUCGGC	1710	uGcuGAGcuAcuucucGGcdTsdT	sense

1121-1140	1711	GCCGAGAAGUAGCUCAGCA	1712	GCCGAGAAGuAGCUcAGcAdTsdT	antis

1268-1287	1713	CAAAGCUCACCCUUGGACA	1714	cAAAGcucAcccuuGGAcAdTsdT	sense

1268-1287	1715	UGUCCAAGGGUGAGCUUUG	1716	UGUCcAAGGGUGAGCUUUGdTsdT	antis

1290-1309	1717	GUGUUCAAAUCUUCAAAGA	1718	GuGuucAAAucuucAAAGAdTsdT	sense

1290-1309	1719	UCUUUGAAGAUUUGAACAC	1720	UCUUUGAAGAUUUGAAcACdTsdT	antis

1308-1327	1721	ACACCACCUGAGGCCAUUG	1722	AcAccAccuGAGGccAuuGdTsdT	sense

1308-1327	1723	CAAUGGCCUCAGGUGGUGU	1724	cAAUGGCCUcAGGUGGUGUdTsdT	antis

1312-1331	1725	CACCUGAGGCCAUUGCACU	1726	cAccuGAGGccAuuGcAcudTsdT	sense

1312-1331	1727	AGUGCAAUGGCCUCAGGUG	1728	AGUGcAAUGGCCUcAGGUGdTsdT	antis

1326-1345	1729	GCACUCUGCUCUAGCCUAC	1730	GcAcucuGcucuAGccuAcdTsdT	sense

1326-1345	1731	GUAGGCUAGAGCAGAGUGC	1732	GuAGGCuAGAGcAGAGUGCdTsdT	antis

1332-1351	1733	UGCUCUAGCCUACUGGAGU	1734	uGcucuAGccuAcuGGAGudTsdT	sense

1332-1351	1735	ACUCCAGUAGGCUAGAGCA	1736	ACUCcAGuAGGCuAGAGcAdTsdT	antis

1406-1425	1737	UGAACUGCGGAGACUCGGA	1738	uGAAcuGcGGAGAcucGGAdTsdT	sense

1406-1425	1739	UCCGAGUCUCCGCAGUUCA	1740	UCCGAGUCUCCGcAGUUcAdTsdT	antis

1407-1426	1741	GAACUGCGGAGACUCGGAG	1742	GAAcuGcGGAGAcucGGAGdTsdT	sense

1407-1426	1743	CUCCGAGUCUCCGCAGUUC	1744	CUCCGAGUCUCCGcAGUUCdTsdT	antis

1415-1434	1745	GAGACUCGGAGCCCAGCUC	1746	GAGAcucGGAGcccAGcucdTsdT	sense

1415-1434	1747	GAGCUGGGCUCCGAGUCUC	1748	GAGCUGGGCUCCGAGUCUCdTsdT	antis

1464-1483	1749	AACUUCAGUCCUGGUGAAC	1750	AAcuucAGuccuGGuGAAcdTsdT	sense

1464-1483	1751	GUUCACCAGGACUGAAGUU	1752	GUUcACcAGGACUGAAGUUdTsdT	antis

1465-1484	1753	ACUUCAGUCCUGGUGAACU	1754	AcuucAGuccuGGuGAAcudTsdT	sense

1465-1484	1755	AGUUCACCAGGACUGAAGU	1756	AGUUcACcAGGACUGAAGUdTsdT	antis

1479-1498	1757	GAACUGUCCAUCCAACCAU	1758	GAAcuGuccAuccAAccAudTsdT	sense

1479-1498	1759	AUGGUUGGAUGGACAGUUC	1760	AUGGUUGGAUGGAcAGUUCdTsdT	antis

1566-1585	1761	UCCUACAACCCAUCCUCAC	1762	uccuAcAAcccAuccucAcdTsdT	sense

1566-1585	1763	GUGAGGAUGGGUUGUAGGA	1764	GUGAGGAUGGGUUGuAGGAdTsdT	antis

1571-1590	1765	CAACCCAUCCUCACAAGCU	1766	cAAcccAuccucAcAAGcudTsdT	sense

1571-1590	1767	AGCUUGUGAGGAUGGGUUG	1768	AGCUUGUGAGGAUGGGUUGdTsdT	antis

1584-1603	1769	CAAGCUUUAACUGAAGCUC	1770	cAAGcuuuAAcuGAAGcucdTsdT	sense

1584-1603	1771	GAGCUUCAGUUAAAGCUUG	1772	GAGCUUcAGUuAAAGCUUGdTsdT	antis

1802-1821	1773	CUAGGCCUCCCUCAGCAGC	1774	cuAGGccucccucAGcAGcdTsdT	sense

1802-1821	1775	GCUGCUGAGGGAGGCCUAG	1776	GCUGCUGAGGGAGGCCuAGdTsdT	antis

1938-1957	1777	CCCCAGGCUACCACUCCUU	1778	ccccAGGcuAccAcuccuudTsdT	sense

1938-1957	1779	AAGGAGUGGUAGCCUGGGG	1780	AAGGAGUGGuAGCCUGGGGdTsdT	antis

1986-2005	1781	AAUAGAACCAGCCCAGCCC	1782	AAuAGAAccAGcccAGcccdTsdT	sense

1986-2005	1783	GGGCUGGGCUGGUUCUAUU	1784	GGGCUGGGCUGGUUCuAUUdTsdT	antis

1987-2006	1785	AUAGAACCAGCCCAGCCCA	1786	AuAGAAccAGcccAGcccAdTsdT	sense

1987-2006	1787	UGGGCUGGGCUGGUUCUAU	1788	UGGGCUGGGCUGGUUCuAUdTsdT	antis

2032-2051	1789	CUGGGUGUAAAUAGAUUGU	1790	cuGGGuGuAAAuAGAuuGudTsdT	sense

2032-2051	1791	ACAAUCUAUUUACACCCAG	1792	AcAAUCuAUUuAcACCcAGdTsdT	antis

2085-2104	1793	CCAUUCAACUUGCCCCCCC	1794	ccAuucAAcuuGcccccccdTsdT	sense

2085-2104	1795	GGGGGGGCAAGUUGAAUGG	1796	GGGGGGGcAAGUUGAAUGGdTsdT	antis

2090-2109	1797	CAACUUGCCCCCCCCAGCU	1798	cAAcuuGccccccccAGcudTsdT	sense

2090-2109	1799	AGCUGGGGGGGGCAAGUUG	1800	AGCUGGGGGGGGcAAGUUGdTsdT	antis

2094-2113	1801	UUGCCCCCCCCAGCUGUAC	1802	uuGccccccccAGcuGuAcdTsdT	sense

2094-2113	1803	GUACAGCUGGGGGGGGCAA	1804	GuAcAGCUGGGGGGGGcAAdTsdT	antis

2101-2120	1805	CCCCAGCUGUACCCCUUCU	1806	ccccAGcuGuAccccuucudTsdT	sense

2101-2120	1807	AGAAGGGGUACAGCUGGGG	1808	AGAAGGGGuAcAGCUGGGGdTsdT	antis

2104-2123	1809	CAGCUGUACCCCUUCUUGU	1810	cAGcuGuAccccuucuuGudTsdT	sense

2104-2123	1811	ACAAGAAGGGGUACAGCUG	1812	AcAAGAAGGGGuAcAGCUGdTsdT	antis

2105-2124	1813	AGCUGUACCCCUUCUUGUC	1814	AGcuGuAccccuucuuGucdTsdT	sense

2105-2124	1815	GACAAGAAGGGGUACAGCU	1816	GAcAAGAAGGGGuAcAGCUdTsdT	antis

2155-2174	1817	UCCUGGAAGGAGGGGAGUA	1818	uccuGGAAGGAGGGGAGuAdTsdT	sense

2155-2174	1819	UACUCCCCUCCUUCCAGGA	1820	uACUCCCCUCCUUCcAGGAdTsdT	antis

2167-2186	1821	GGGAGUAGAGAGAGUCCCU	1822	GGGAGuAGAGAGAGucccudTsdT	sense

2167-2186	1823	AGGGACUCUCUCUACUCCC	1824	AGGGACUCUCUCuACUCCCdTsdT	antis

2174-2193	1825	GAGAGAGUCCCUGGUGUCU	1826	GAGAGAGucccuGGuGucudTsdT	sense

2174-2193	1827	AGACACCAGGGACUCUCUC	1828	AGAcACcAGGGACUCUCUCdTsdT	antis

2216-2235	1829	UGUGUACAGACCUCUGUUC	1830	uGuGuAcAGAccucuGuucdTsdT	sense

2216-2235	1831	GAACAGAGGUCUGUACACA	1832	GAAcAGAGGUCUGuAcAcAdTsdT	antis

2217-2236	1833	GUGUACAGACCUCUGUUCA	1834	GuGuAcAGAccucuGuucAdTsdT	sense

2217-2236	1835	UGAACAGAGGUCUGUACAC	1836	UGAAcAGAGGUCUGuAcACdTsdT	antis

2236-2255	1837	AUAAAUUAUUGGCAUGAAA	1838	AuAAAuuAuuGGcAuGAAAdTsdT	sense

2236-2255	1839	UUUCAUGCCAAUAAUUUAU	1840	UUUcAUGCcAAuAAUUuAUdTsdT	antis

2237-2256	1841	UAAAUUAUUGGCAUGAAAC	1842	uAAAuuAuuGGcAuGAAAcdTsdT	sense

2237-2256	1843	GUUUCAUGCCAAUAAUUUA	1844	GUUUcAUGCcAAuAAUUuAdTsdT	antis

2245-2264	1845	UGGCAUGAAACCCUUAAAA	1846	uGGcAuGAAAcccuuAAAAdTsdT	sense

2245-2264	1847	UUUUAAGGGUUUCAUGCCA	1848	UUUuAAGGGUUUcAUGCcAdTsdT	antis

13-32	1849	AAGCCGACGGCAGAGGGAC	1850	AAGccGAcGGcAGAGGGAcdTsdT	sense

13-32	1851	GUCCCUCUGCCGUCGGCUU	1852	GUCCCUCUGCCGUCGGCUUdTsdT	antis

21-40	1853	GGCAGAGGGACUUCAUCUC	1854	GGcAGAGGGAcuucAucucdTsdT	sense

21-40	1855	GAGAUGAAGUCCCUCUGCC	1856	GAGAUGAAGUCCCUCUGCCdTsdT	antis

22-41	1857	GCAGAGGGACUUCAUCUCC	1858	GcAGAGGGAcuucAucuccdTsdT	sense

22-41	1859	GGAGAUGAAGUCCCUCUGC	1860	GGAGAUGAAGUCCCUCUGCdTsdT	antis

23-42	1861	CAGAGGGACUUCAUCUCCC	1862	cAGAGGGAcuucAucucccdTsdT	sense

23-42	1863	GGGAGAUGAAGUCCCUCUG	1864	GGGAGAUGAAGUCCCUCUGdTsdT	antis

25-44	1865	GAGGGACUUCAUCUCCCGG	1866	GAGGGAcuucAucucccGGdTsdT	sense

25-44	1867	CCGGGAGAUGAAGUCCCUC	1868	CCGGGAGAUGAAGUCCCUCdTsdT	antis

30-49	1869	ACUUCAUCUCCCGGCGUGC	1870	AcuucAucucccGGcGuGcdTsdT	sense

30-49	1871	GCACGCCGGGAGAUGAAGU	1872	GcACGCCGGGAGAUGAAGUdTsdT	antis

31-50	1873	CUUCAUCUCCCGGCGUGCC	1874	cuucAucucccGGcGuGccdTsdT	sense

31-50	1875	GGCACGCCGGGAGAUGAAG	1876	GGcACGCCGGGAGAUGAAGdTsdT	antis

32-51	1877	UUCAUCUCCCGGCGUGCCC	1878	uucAucucccGGcGuGcccdTsdT	sense

32-51	1879	GGGCACGCCGGGAGAUGAA	1880	GGGcACGCCGGGAGAUGAAdTsdT	antis

36-55	1881	UCUCCCGGCGUGCCCCGCG	1882	ucucccGGcGuGccccGcGdTsdT	sense

36-55	1883	CGCGGGGCACGCCGGGAGA	1884	CGCGGGGcACGCCGGGAGAdTsdT	antis

41-60	1885	CGGCGUGCCCCGCGGCGGG	1886	cGGcGuGccccGcGGcGGGdTsdT	sense

41-60	1887	CCCGCCGCGGGGCACGCCG	1888	CCCGCCGCGGGGcACGCCGdTsdT	antis

44-63	1889	CGUGCCCCGCGGCGGGCGC	1890	cGuGccccGcGGcGGGcGcdTsdT	sense

44-63	1891	GCGCCCGCCGCGGGGCACG	1892	GCGCCCGCCGCGGGGcACGdTsdT	antis

45-64	1893	GUGCCCCGCGGCGGGCGCU	1894	GuGccccGcGGcGGGcGcudTsdT	sense

45-64	1895	AGCGCCCGCCGCGGGGCAC	1896	AGCGCCCGCCGCGGGGcACdTsdT	antis

52-71	1897	GCGGCGGGCGCUGGGCCGG	1898	GcGGcGGGcGcuGGGccGGdTsdT	sense

52-71	1899	CCGGCCCAGCGCCCGCCGC	1900	CCGGCCcAGCGCCCGCCGCdTsdT	antis

58-77	1901	GGCGCUGGGCCGGAGCCGG	1902	GGcGcuGGGccGGAGccGGdTsdT	sense

58-77	1903	CCGGCUCCGGCCCAGCGCC	1904	CCGGCUCCGGCCcAGCGCCdTsdT	antis

84-103	1905	ACGGCGCGGCCUGGAAGAG	1906	AcGGcGcGGccuGGAAGAGdTsdT	sense

84-103	1907	CUCUUCCAGGCCGCGCCGU	1908	CUCUUCcAGGCCGCGCCGUdTsdT	antis

88-107	1909	CGCGGCCUGGAAGAGGCCG	1910	cGcGGccuGGAAGAGGccGdTsdT	sense

88-107	1911	CGGCCUCUUCCAGGCCGCG	1912	CGGCCUCUUCcAGGCCGCGdTsdT	antis

94-113	1913	CUGGAAGAGGCCGGAGCCC	1914	cuGGAAGAGGccGGAGcccdTsdT	sense

94-113	1915	GGGCUCCGGCCUCUUCCAG	1916	GGGCUCCGGCCUCUUCcAGdTsdT	antis

98-117	1917	AAGAGGCCGGAGCCCAGGG	1918	AAGAGGccGGAGcccAGGGdTsdT	sense

98-117	1919	CCCUGGGCUCCGGCCUCUU	1920	CCCUGGGCUCCGGCCUCUUdTsdT	antis

100-119	1921	GAGGCCGGAGCCCAGGGGA	1922	GAGGccGGAGcccAGGGGAdTsdT	sense

100-119	1923	UCCCCUGGGCUCCGGCCUC	1924	UCCCCUGGGCUCCGGCCUCdTsdT	antis

144-163	1925	GCAGCCCAGGCAGCCCGAG	1926	GcAGcccAGGcAGcccGAGdTsdT	sense

144-163	1927	CUCGGGCUGCCUGGGCUGC	1928	CUCGGGCUGCCUGGGCUGCdTsdT	antis

145-164	1929	CAGCCCAGGCAGCCCGAGC	1930	cAGcccAGGcAGcccGAGcdTsdT	sense

145-164	1931	GCUCGGGCUGCCUGGGCUG	1932	GCUCGGGCUGCCUGGGCUGdTsdT	antis

148-167	1933	CCCAGGCAGCCCGAGCCCC	1934	cccAGGcAGcccGAGccccdTsdT	sense

148-167	1935	GGGGCUCGGGCUGCCUGGG	1936	GGGGCUCGGGCUGCCUGGGdTsdT	antis

149-168	1937	CCAGGCAGCCCGAGCCCCG	1938	ccAGGcAGcccGAGccccGdTsdT	sense

149-168	1939	CGGGGCUCGGGCUGCCUGG	1940	CGGGGCUCGGGCUGCCUGGdTsdT	antis

157-176	1941	CCCGAGCCCCGCGGCCUGG	1942	cccGAGccccGcGGccuGGdTsdT	sense

157-176	1943	CCAGGCCGCGGGGCUCGGG	1944	CcAGGCCGCGGGGCUCGGGdTsdT	antis

168-187	1945	CGGCCUGGGCCUGCGCUCG	1946	cGGccuGGGccuGcGcucGdTsdT	sense

168-187	1947	CGAGCGCAGGCCCAGGCCG	1948	CGAGCGcAGGCCcAGGCCGdTsdT	antis

169-188	1949	GGCCUGGGCCUGCGCUCGG	1950	GGccuGGGccuGcGcucGGdTsdT	sense

169-188	1951	CCGAGCGCAGGCCCAGGCC	1952	CCGAGCGcAGGCCcAGGCCdTsdT	antis

175-194	1953	GGCCUGCGCUCGGCGCCAU	1954	GGccuGcGcucGGcGccAudTsdT	sense

175-194	1955	AUGGCGCCGAGCGCAGGCC	1956	AUGGCGCCGAGCGcAGGCCdTsdT	antis

179-198	1957	UGCGCUCGGCGCCAUGAGC	1958	uGcGcucGGcGccAuGAGcdTsdT	sense

179-198	1959	GCUCAUGGCGCCGAGCGCA	1960	GCUcAUGGCGCCGAGCGcAdTsdT	antis

192-211	1961	AUGAGCGGCGGCGGGCCUU	1962	AuGAGcGGcGGcGGGccuudTsdT	sense

192-211	1963	AAGGCCCGCCGCCGCUCAU	1964	AAGGCCCGCCGCCGCUcAUdTsdT	antis

193-212	1965	UGAGCGGCGGCGGGCCUUC	1966	uGAGcGGcGGcGGGccuucdTsdT	sense

193-212	1967	GAAGGCCCGCCGCCGCUCA	1968	GAAGGCCCGCCGCCGCUcAdTsdT	antis

194-213	1969	GAGCGGCGGCGGGCCUUCG	1970	GAGcGGcGGcGGGccuucGdTsdT	sense

194-213	1971	CGAAGGCCCGCCGCCGCUC	1972	CGAAGGCCCGCCGCCGCUCdTsdT	antis

195-214	1973	AGCGGCGGCGGGCCUUCGG	1974	AGcGGcGGcGGGccuucGGdTsdT	sense

195-214	1975	CCGAAGGCCCGCCGCCGCU	1976	CCGAAGGCCCGCCGCCGCUdTsdT	antis

197-216	1977	CGGCGGCGGGCCUUCGGGA	1978	cGGcGGcGGGccuucGGGAdTsdT	sense

197-216	1979	UCCCGAAGGCCCGCCGCCG	1980	UCCCGAAGGCCCGCCGCCGdTsdT	antis

200-219	1981	CGGCGGGCCUUCGGGAGGC	1982	cGGcGGGccuucGGGAGGcdTsdT	sense

200-219	1983	GCCUCCCGAAGGCCCGCCG	1984	GCCUCCCGAAGGCCCGCCGdTsdT	antis

246-265	1985	ACCAGCUCGUUCGCGGAGC	1986	AccAGcucGuucGcGGAGcdTsdT	sense

246-265	1987	GCUCCGCGAACGAGCUGGU	1988	GCUCCGCGAACGAGCUGGUdTsdT	antis

253-272	1989	CGUUCGCGGAGCCAGGAGG	1990	cGuucGcGGAGccAGGAGGdTsdT	sense

253-272	1991	CCUCCUGGCUCCGCGAACG	1992	CCUCCUGGCUCCGCGAACGdTsdT	antis

257-276	1993	CGCGGAGCCAGGAGGCGGA	1994	cGcGGAGccAGGAGGcGGAdTsdT	sense

257-276	1995	UCCGCCUCCUGGCUCCGCG	1996	UCCGCCUCCUGGCUCCGCGdTsdT	antis

258-277	1997	GCGGAGCCAGGAGGCGGAG	1998	GcGGAGccAGGAGGcGGAGdTsdT	sense

258-277	1999	CUCCGCCUCCUGGCUCCGC	2000	CUCCGCCUCCUGGCUCCGCdTsdT	antis

297-316	2001	CCCGGGGGCUCGGCCUCUG	2002	cccGGGGGcucGGccucuGdTsdT	sense

297-316	2003	CAGAGGCCGAGCCCCCGGG	2004	cAGAGGCCGAGCCCCCGGGdTsdT	antis

298-317	2005	CCGGGGGCUCGGCCUCUGG	2006	ccGGGGGcucGGccucuGGdTsdT	sense

298-317	2007	CCAGAGGCCGAGCCCCCGG	2008	CcAGAGGCCGAGCCCCCGGdTsdT	antis

321-340	2009	GGAGGCACUGGCGGCGGGA	2010	GGAGGcAcuGGcGGcGGGAdTsdT	sense

321-340	2011	UCCCGCCGCCAGUGCCUCC	2012	UCCCGCCGCcAGUGCCUCCdTsdT	antis

323-342	2013	AGGCACUGGCGGCGGGAAA	2014	AGGcAcuGGcGGcGGGAAAdTsdT	sense

323-342	2015	UUUCCCGCCGCCAGUGCCU	2016	UUUCCCGCCGCcAGUGCCUdTsdT	antis

325-344	2017	GCACUGGCGGCGGGAAAGC	2018	GcAcuGGcGGcGGGAAAGcdTsdT	sense

325-344	2019	GCUUUCCCGCCGCCAGUGC	2020	GCUUUCCCGCCGCcAGUGCdTsdT	antis

326-345	2021	CACUGGCGGCGGGAAAGCG	2022	cAcuGGcGGcGGGAAAGcGdTsdT	sense

326-345	2023	CGCUUUCCCGCCGCCAGUG	2024	CGCUUUCCCGCCGCcAGUGdTsdT	antis

338-357	2025	GAAAGCGUCAGUCGGGGCU	2026	GAAAGcGucAGucGGGGcudTsdT	sense

338-357	2027	AGCCCCGACUGACGCUUUC	2028	AGCCCCGACUGACGCUUUCdTsdT	antis

370-389	2029	UGGGAGCCUCGAGCUCCGG	2030	uGGGAGccucGAGcuccGGdTsdT	sense

370-389	2031	CCGGAGCUCGAGGCUCCCA	2032	CCGGAGCUCGAGGCUCCcAdTsdT	antis

371-390	2033	GGGAGCCUCGAGCUCCGGG	2034	GGGAGccucGAGcuccGGGdTsdT	sense

371-390	2035	CCCGGAGCUCGAGGCUCCC	2036	CCCGGAGCUCGAGGCUCCCdTsdT	antis

372-391	2037	GGAGCCUCGAGCUCCGGGG	2038	GGAGccucGAGcuccGGGGdTsdT	sense

372-391	2039	CCCCGGAGCUCGAGGCUCC	2040	CCCCGGAGCUCGAGGCUCCdTsdT	antis

373-392	2041	GAGCCUCGAGCUCCGGGGG	2042	GAGccucGAGcuccGGGGGdTsdT	sense

373-392	2043	CCCCCGGAGCUCGAGGCUC	2044	CCCCCGGAGCUCGAGGCUCdTsdT	antis

375-394	2045	GCCUCGAGCUCCGGGGGUG	2046	GccucGAGcuccGGGGGuGdTsdT	sense

375-394	2047	CACCCCCGGAGCUCGAGGC	2048	cACCCCCGGAGCUCGAGGCdTsdT	antis

380-399	2049	GAGCUCCGGGGGUGGCCCC	2050	GAGcuccGGGGGuGGccccdTsdT	sense

380-399	2051	GGGGCCACCCCCGGAGCUC	2052	GGGGCcACCCCCGGAGCUCdTsdT	antis

385-404	2053	CCGGGGGUGGCCCCAGCGG	2054	ccGGGGGuGGccccAGcGGdTsdT	sense

385-404	2055	CCGCUGGGGCCACCCCCGG	2056	CCGCUGGGGCcACCCCCGGdTsdT	antis

389-408	2057	GGGUGGCCCCAGCGGCAGC	2058	GGGuGGccccAGcGGcAGcdTsdT	sense

389-408	2059	GCUGCCGCUGGGGCCACCC	2060	GCUGCCGCUGGGGCcACCCdTsdT	antis

439-458	2061	GCACUAGCUUCCCGCCGCC	2062	GcAcuAGcuucccGccGccdTsdT	sense

439-458	2063	GGCGGCGGGAAGCUAGUGC	2064	GGCGGCGGGAAGCuAGUGCdTsdT	antis

440-459	2065	CACUAGCUUCCCGCCGCCG	2066	cAcuAGcuucccGccGccGdTsdT	sense

440-459	2067	CGGCGGCGGGAAGCUAGUG	2068	CGGCGGCGGGAAGCuAGUGdTsdT	antis

445-464	2069	GCUUCCCGCCGCCGGGAGU	2070	GcuucccGccGccGGGAGudTsdT	sense

445-464	2071	ACUCCCGGCGGCGGGAAGC	2072	ACUCCCGGCGGCGGGAAGCdTsdT	antis

447-466	2073	UUCCCGCCGCCGGGAGUGA	2074	uucccGccGccGGGAGuGAdTsdT	sense

447-466	2075	UCACUCCCGGCGGCGGGAA	2076	UcACUCCCGGCGGCGGGAAdTsdT	antis

463-482	2077	UGAAGCUGGGCCGUGACAG	2078	uGAAGcuGGGccGuGAcAGdTsdT	sense

463-482	2079	CUGUCACGGCCCAGCUUCA	2080	CUGUcACGGCCcAGCUUcAdTsdT	antis

471-490	2081	GGCCGUGACAGCGGGAAGG	2082	GGccGuGAcAGcGGGAAGGdTsdT	sense

471-490	2083	CCUUCCCGCUGUCACGGCC	2084	CCUUCCCGCUGUcACGGCCdTsdT	antis

474-493	2085	CGUGACAGCGGGAAGGUGA	2086	cGuGAcAGcGGGAAGGuGAdTsdT	sense

474-493	2087	UCACCUUCCCGCUGUCACG	2088	UcACCUUCCCGCUGUcACGdTsdT	antis

492-511	2089	ACCACAGUGGUAGCCACUG	2090	AccAcAGuGGuAGccAcuGdTsdT	sense

492-511	2091	CAGUGGCUACCACUGUGGU	2092	cAGUGGCuACcACUGUGGUdTsdT	antis

495-514	2093	ACAGUGGUAGCCACUGUAG	2094	AcAGuGGuAGccAcuGuAGdTsdT	sense

495-514	2095	CUACAGUGGCUACCACUGU	2096	CuAcAGUGGCuACcACUGUdTsdT	antis

496-515	2097	CAGUGGUAGCCACUGUAGG	2098	cAGuGGuAGccAcuGuAGGdTsdT	sense

496-515	2099	CCUACAGUGGCUACCACUG	2100	CCuAcAGUGGCuACcACUGdTsdT	antis

506-525	2101	CACUGUAGGCCAAGGCCCA	2102	cAcuGuAGGccAAGGcccAdTsdT	sense

506-525	2103	UGGGCCUUGGCCUACAGUG	2104	UGGGCCUUGGCCuAcAGUGdTsdT	antis

507-526	2105	ACUGUAGGCCAAGGCCCAG	2106	AcuGuAGGccAAGGcccAGdTsdT	sense

507-526	2107	CUGGGCCUUGGCCUACAGU	2108	CUGGGCCUUGGCCuAcAGUdTsdT	antis

509-528	2109	UGUAGGCCAAGGCCCAGAG	2110	uGuAGGccAAGGcccAGAGdTsdT	sense

509-528	2111	CUCUGGGCCUUGGCCUACA	2112	CUCUGGGCCUUGGCCuAcAdTsdT	antis

510-529	2113	GUAGGCCAAGGCCCAGAGC	2114	GuAGGccAAGGcccAGAGcdTsdT	sense

510-529	2115	GCUCUGGGCCUUGGCCUAC	2116	GCUCUGGGCCUUGGCCuACdTsdT	antis

582-601	2117	GGAGUAGUAUACCAGGCAC	2118	GGAGuAGuAuAccAGGcAcdTsdT	sense

582-601	2119	GUGCCUGGUAUACUACUCC	2120	GUGCCUGGuAuACuACUCCdTsdT	antis

585-604	2121	GUAGUAUACCAGGCACGGC	2122	GuAGuAuAccAGGcAcGGcdTsdT	sense

585-604	2123	GCCGUGCCUGGUAUACUAC	2124	GCCGUGCCUGGuAuACuACdTsdT	antis

595-614	2125	AGGCACGGCUGGCAGAGAC	2126	AGGcAcGGcuGGcAGAGAcdTsdT	sense

595-614	2127	GUCUCUGCCAGCCGUGCCU	2128	GUCUCUGCcAGCCGUGCCUdTsdT	antis

596-615	2129	GGCACGGCUGGCAGAGACG	2130	GGcAcGGcuGGcAGAGAcGdTsdT	sense

596-615	2131	CGUCUCUGCCAGCCGUGCC	2132	CGUCUCUGCcAGCCGUGCCdTsdT	antis

597-616	2133	GCACGGCUGGCAGAGACGA	2134	GcAcGGcuGGcAGAGAcGAdTsdT	sense

597-616	2135	UCGUCUCUGCCAGCCGUGC	2136	UCGUCUCUGCcAGCCGUGCdTsdT	antis

610-629	2137	AGACGAGGGAACUGGUGGC	2138	AGAcGAGGGAAcuGGuGGcdTsdT	sense

610-629	2139	GCCACCAGUUCCCUCGUCU	2140	GCcACcAGUUCCCUCGUCUdTsdT	antis

612-631	2141	ACGAGGGAACUGGUGGCCA	2142	AcGAGGGAAcuGGuGGccAdTsdT	sense

612-631	2143	UGGCCACCAGUUCCCUCGU	2144	UGGCcACcAGUUCCCUCGUdTsdT	antis

614-633	2145	GAGGGAACUGGUGGCCAUC	2146	GAGGGAAcuGGuGGccAucdTsdT	sense

614-633	2147	GAUGGCCACCAGUUCCCUC	2148	GAUGGCcACcAGUUCCCUCdTsdT	antis

646-665	2149	AGGACAAAAGGUUCAAGAA	2150	AGGAcAAAAGGuucAAGAAdTsdT	sense

646-665	2151	UUCUUGAACCUUUUGUCCU	2152	UUCUUGAACCUUUUGUCCUdTsdT	antis

661-680	2153	AGAACCGAGAACUGCAGAU	2154	AGAAccGAGAAcuGcAGAudTsdT	sense

661-680	2155	AUCUGCAGUUCUCGGUUCU	2156	AUCUGcAGUUCUCGGUUCUdTsdT	antis

668-687	2157	AGAACUGCAGAUUAUGCGU	2158	AGAAcuGcAGAuuAuGcGudTsdT	sense

668-687	2159	ACGCAUAAUCUGCAGUUCU	2160	ACGcAuAAUCUGcAGUUCUdTsdT	antis

669-688	2161	GAACUGCAGAUUAUGCGUA	2162	GAAcuGcAGAuuAuGcGuAdTsdT	sense

669-688	2163	UACGCAUAAUCUGCAGUUC	2164	uACGcAuAAUCUGcAGUUCdTsdT	antis

703-722	2165	AUAUUGUGAGGCUGCGGUA	2166	AuAuuGuGAGGcuGcGGuAdTsdT	sense

703-722	2167	UACCGCAGCCUCACAAUAU	2168	uACCGcAGCCUcAcAAuAUdTsdT	antis

704-723	2169	UAUUGUGAGGCUGCGGUAC	2170	uAuuGuGAGGcuGcGGuAcdTsdT	sense

704-723	2171	GUACCGCAGCCUCACAAUA	2172	GuACCGcAGCCUcAcAAuAdTsdT	antis

705-724	2173	AUUGUGAGGCUGCGGUACU	2174	AuuGuGAGGcuGcGGuAcudTsdT	sense

705-724	2175	AGUACCGCAGCCUCACAAU	2176	AGuACCGcAGCCUcAcAAUdTsdT	antis

738-757	2177	GGGGAGAAGAAGGACGAGC	2178	GGGGAGAAGAAGGAcGAGcdTsdT	sense

738-757	2179	GCUCGUCCUUCUUCUCCCC	2180	GCUCGUCCUUCUUCUCCCCdTsdT	antis

824-843	2181	GGCCAAGCUGAUCACCCCU	2182	GGccAAGcuGAucAccccudTsdT	sense

824-843	2183	AGGGGUGAUCAGCUUGGCC	2184	AGGGGUGAUcAGCUUGGCCdTsdT	antis

827-846	2185	CAAGCUGAUCACCCCUAUC	2186	cAAGcuGAucAccccuAucdTsdT	sense

827-846	2187	GAUAGGGGUGAUCAGCUUG	2188	GAuAGGGGUGAUcAGCUUGdTsdT	antis

879-898	2189	CGGAGCUUGGCCUACAUCC	2190	cGGAGcuuGGccuAcAuccdTsdT	sense

879-898	2191	GGAUGUAGGCCAAGCUCCG	2192	GGAUGuAGGCcAAGCUCCGdTsdT	antis

880-899	2193	GGAGCUUGGCCUACAUCCA	2194	GGAGcuuGGccuAcAuccAdTsdT	sense

880-899	2195	UGGAUGUAGGCCAAGCUCC	2196	UGGAUGuAGGCcAAGCUCCdTsdT	antis

881-900	2197	GAGCUUGGCCUACAUCCAC	2198	GAGcuuGGccuAcAuccAcdTsdT	sense

881-900	2199	GUGGAUGUAGGCCAAGCUC	2200	GUGGAUGuAGGCcAAGCUCdTsdT	antis

884-903	2201	CUUGGCCUACAUCCACUCC	2202	cuuGGccuAcAuccAcuccdTsdT	sense

884-903	2203	GGAGUGGAUGUAGGCCAAG	2204	GGAGUGGAUGuAGGCcAAGdTsdT	antis

886-905	2205	UGGCCUACAUCCACUCCCA	2206	uGGccuAcAuccAcucccAdTsdT	sense

886-905	2207	UGGGAGUGGAUGUAGGCCA	2208	UGGGAGUGGAUGuAGGCcAdTsdT	antis

896-915	2209	CCACUCCCAAGGUGUGUGU	2210	ccAcucccAAGGuGuGuGudTsdT	sense

896-915	2211	ACACACACCUUGGGAGUGG	2212	AcAcAcACCUUGGGAGUGGdTsdT	antis

916-935	2213	ACCGUGACAUCAAGCCCCA	2214	AccGuGAcAucAAGccccAdTsdT	sense

916-935	2215	UGGGGCUUGAUGUCACGGU	2216	UGGGGCUUGAUGUcACGGUdTsdT	antis

917-936	2217	CCGUGACAUCAAGCCCCAG	2218	ccGuGAcAucAAGccccAGdTsdT	sense

917-936	2219	CUGGGGCUUGAUGUCACGG	2220	CUGGGGCUUGAUGUcACGGdTsdT	antis

931-950	2221	CCCAGAAUUUGCUUGUGGA	2222	cccAGAAuuuGcuuGuGGAdTsdT	sense

931-950	2223	UCCACAAGCAAAUUCUGGG	2224	UCcAcAAGcAAAUUCUGGGdTsdT	antis

933-952	2225	CAGAAUUUGCUUGUGGACC	2226	cAGAAuuuGcuuGuGGAccdTsdT	sense

933-952	2227	GGUCCACAAGCAAAUUCUG	2228	GGUCcAcAAGcAAAUUCUGdTsdT	antis

991-1010	2229	CAAAGCAGCUGGUUCGGGG	2230	cAAAGcAGcuGGuucGGGGdTsdT	sense

991-1010	2231	CCCCGAACCAGCUGCUUUG	2232	CCCCGAACcAGCUGCUUUGdTsdT	antis

993-1012	2233	AAGCAGCUGGUUCGGGGGG	2234	AAGcAGcuGGuucGGGGGGdTsdT	sense

993-1012	2235	CCCCCCGAACCAGCUGCUU	2236	CCCCCCGAACcAGCUGCUUdTsdT	antis

1000-1019	2237	UGGUUCGGGGGGAGCCCAA	2238	uGGuucGGGGGGAGcccAAdTsdT	sense

1000-1019	2239	UUGGGCUCCCCCCGAACCA	2240	UUGGGCUCCCCCCGAACcAdTsdT	antis

1003-1022	2241	UUCGGGGGGAGCCCAAUGU	2242	uucGGGGGGAGcccAAuGudTsdT	sense

1003-1022	2243	ACAUUGGGCUCCCCCCGAA	2244	AcAUUGGGCUCCCCCCGAAdTsdT	antis

1004-1023	2245	UCGGGGGGAGCCCAAUGUG	2246	ucGGGGGGAGcccAAuGuGdTsdT	sense

1004-1023	2247	CACAUUGGGCUCCCCCCGA	2248	cAcAUUGGGCUCCCCCCGAdTsdT	antis

1006-1025	2249	GGGGGGAGCCCAAUGUGUC	2250	GGGGGGAGcccAAuGuGucdTsdT	sense

1006-1025	2251	GACACAUUGGGCUCCCCCC	2252	GAcAcAUUGGGCUCCCCCCdTsdT	antis

1015-1034	2253	CCAAUGUGUCCUACAUCUG	2254	ccAAuGuGuccuAcAucuGdTsdT	sense

1015-1034	2255	CAGAUGUAGGACACAUUGG	2256	cAGAUGuAGGAcAcAUUGGdTsdT	antis

1016-1035	2257	CAAUGUGUCCUACAUCUGC	2258	cAAuGuGuccuAcAucuGcdTsdT	sense

1016-1035	2259	GCAGAUGUAGGACACAUUG	2260	GcAGAUGuAGGAcAcAUUGdTsdT	antis

1031-1050	2261	CUGCUCUCGGUACUACCGU	2262	cuGcucucGGuAcuAccGudTsdT	sense

1031-1050	2263	ACGGUAGUACCGAGAGCAG	2264	ACGGuAGuACCGAGAGcAGdTsdT	antis

1045-1064	2265	ACCGUGCUCCAGAACUCAU	2266	AccGuGcuccAGAAcucAudTsdT	sense

1045-1064	2267	AUGAGUUCUGGAGCACGGU	2268	AUGAGUUCUGGAGcACGGUdTsdT	antis

1047-1066	2269	CGUGCUCCAGAACUCAUCU	2270	cGuGcuccAGAAcucAucudTsdT	sense

1047-1066	2271	AGAUGAGUUCUGGAGCACG	2272	AGAUGAGUUCUGGAGcACGdTsdT	antis

1051-1070	2273	CUCCAGAACUCAUCUUUGG	2274	cuccAGAAcucAucuuuGGdTsdT	sense

1051-1070	2275	CCAAAGAUGAGUUCUGGAG	2276	CcAAAGAUGAGUUCUGGAGdTsdT	antis

1055-1074	2277	AGAACUCAUCUUUGGAGCC	2278	AGAAcucAucuuuGGAGccdTsdT	sense

1055-1074	2279	GGCUCCAAAGAUGAGUUCU	2280	GGCUCcAAAGAUGAGUUCUdTsdT	antis

1058-1077	2281	ACUCAUCUUUGGAGCCACA	2282	AcucAucuuuGGAGccAcAdTsdT	sense

1058-1077	2283	UGUGGCUCCAAAGAUGAGU	2284	UGUGGCUCcAAAGAUGAGUdTsdT	antis

1061-1080	2285	CAUCUUUGGAGCCACAGAU	2286	cAucuuuGGAGccAcAGAudTsdT	sense

1061-1080	2287	AUCUGUGGCUCCAAAGAUG	2288	AUCUGUGGCUCcAAAGAUGdTsdT	antis

1062-1081	2289	AUCUUUGGAGCCACAGAUU	2290	AucuuuGGAGccAcAGAuudTsdT	sense

1062-1081	2291	AAUCUGUGGCUCCAAAGAU	2292	AAUCUGUGGCUCcAAAGAUdTsdT	antis

1086-1105	2293	UCGUCCAUCGAUGUGUGGU	2294	ucGuccAucGAuGuGuGGudTsdT	sense

1086-1105	2295	ACCACACAUCGAUGGACGA	2296	ACcAcAcAUCGAUGGACGAdTsdT	antis

1099-1118	2297	UGUGGUCGGCUGGCUGUGU	2298	uGuGGucGGcuGGcuGuGudTsdT	sense

1099-1118	2299	ACACAGCCAGCCGACCACA	2300	AcAcAGCcAGCCGACcAcAdTsdT	antis

1100-1119	2301	GUGGUCGGCUGGCUGUGUA	2302	GuGGucGGcuGGcuGuGuAdTsdT	sense

1100-1119	2303	UACACAGCCAGCCGACCAC	2304	uAcAcAGCcAGCCGACcACdTsdT	antis

1101-1120	2305	UGGUCGGCUGGCUGUGUAC	2306	uGGucGGcuGGcuGuGuAcdTsdT	sense

1101-1120	2307	GUACACAGCCAGCCGACCA	2308	GuAcAcAGCcAGCCGACcAdTsdT	antis

1112-1131	2309	CUGUGUACUUGCUGAGCUA	2310	cuGuGuAcuuGcuGAGcuAdTsdT	sense

1112-1131	2311	UAGCUCAGCAAGUACACAG	2312	uAGCUcAGcAAGuAcAcAGdTsdT	antis

1114-1133	2313	GUGUACUUGCUGAGCUACU	2314	GuGuAcuuGcuGAGcuAcudTsdT	sense

1114-1133	2315	AGUAGCUCAGCAAGUACAC	2316	AGuAGCUcAGcAAGuAcACdTsdT	antis

1115-1134	2317	UGUACUUGCUGAGCUACUU	2318	uGuAcuuGcuGAGcuAcuudTsdT	sense

1115-1134	2319	AAGUAGCUCAGCAAGUACA	2320	AAGuAGCUcAGcAAGuAcAdTsdT	antis

1119-1138	2321	CUUGCUGAGCUACUUCUCG	2322	cuuGcuGAGcuAcuucucGdTsdT	sense

1119-1138	2323	CGAGAAGUAGCUCAGCAAG	2324	CGAGAAGuAGCUcAGcAAGdTsdT	antis

1126-1145	2325	AGCUACUUCUCGGCCAGCC	2326	AGcuAcuucucGGccAGccdTsdT	sense

1126-1145	2327	GGCUGGCCGAGAAGUAGCU	2328	GGCUGGCCGAGAAGuAGCUdTsdT	antis

1139-1158	2329	CCAGCCCAUCUUCCCUGGG	2330	ccAGcccAucuucccuGGGdTsdT	sense

1139-1158	2331	CCCAGGGAAGAUGGGCUGG	2332	CCcAGGGAAGAUGGGCUGGdTsdT	antis

1146-1165	2333	AUCUUCCCUGGGGACAGUG	2334	AucuucccuGGGGAcAGuGdTsdT	sense

1146-1165	2335	CACUGUCCCCAGGGAAGAU	2336	cACUGUCCCcAGGGAAGAUdTsdT	antis

1224-1243	2337	CGAGAGAUGAACCCUAACU	2338	cGAGAGAuGAAcccuAAcudTsdT	sense

1224-1243	2339	AGUUAGGGUUCAUCUCUCG	2340	AGUuAGGGUUcAUCUCUCGdTsdT	antis

1263-1282	2341	CAGAUCAAAGCUCACCCUU	2342	cAGAucAAAGcucAcccuudTsdT	sense

1263-1282	2343	AAGGGUGAGCUUUGAUCUG	2344	AAGGGUGAGCUUUGAUCUGdTsdT	antis

1264-1283	2345	AGAUCAAAGCUCACCCUUG	2346	AGAucAAAGcucAcccuuGdTsdT	sense

1264-1283	2347	CAAGGGUGAGCUUUGAUCU	2348	cAAGGGUGAGCUUUGAUCUdTsdT	antis

1267-1286	2349	UCAAAGCUCACCCUUGGAC	2350	ucAAAGcucAcccuuGGAcdTsdT	sense

1267-1286	2351	GUCCAAGGGUGAGCUUUGA	2352	GUCcAAGGGUGAGCUUUGAdTsdT	antis

1285-1304	2353	CAAAGGUGUUCAAAUCUUC	2354	cAAAGGuGuucAAAucuucdTsdT	sense

1285-1304	2355	GAAGAUUUGAACACCUUUG	2356	GAAGAUUUGAAcACCUUUGdTsdT	antis

1286-1305	2357	AAAGGUGUUCAAAUCUUCA	2358	AAAGGuGuucAAAucuucAdTsdT	sense

1286-1305	2359	UGAAGAUUUGAACACCUUU	2360	UGAAGAUUUGAAcACCUUUdTsdT	antis

1295-1314	2361	CAAAUCUUCAAAGACACCA	2362	cAAAucuucAAAGAcAccAdTsdT	sense

1295-1314	2363	UGGUGUCUUUGAAGAUUUG	2364	UGGUGUCUUUGAAGAUUUGdTsdT	antis

1304-1323	2365	AAAGACACCACCUGAGGCC	2366	AAAGAcAccAccuGAGGccdTsdT	sense

1304-1323	2367	GGCCUCAGGUGGUGUCUUU	2368	GGCCUcAGGUGGUGUCUUUdTsdT	antis

1306-1325	2369	AGACACCACCUGAGGCCAU	2370	AGAcAccAccuGAGGccAudTsdT	sense

1306-1325	2371	AUGGCCUCAGGUGGUGUCU	2372	AUGGCCUcAGGUGGUGUCUdTsdT	antis

1307-1326	2373	GACACCACCUGAGGCCAUU	2374	GAcAccAccuGAGGccAuudTsdT	sense

1307-1326	2375	AAUGGCCUCAGGUGGUGUC	2376	AAUGGCCUcAGGUGGUGUCdTsdT	antis

1310-1329	2377	ACCACCUGAGGCCAUUGCA	2378	AccAccuGAGGccAuuGcAdTsdT	sense

1310-1329	2379	UGCAAUGGCCUCAGGUGGU	2380	UGcAAUGGCCUcAGGUGGUdTsdT	antis

1313-1332	2381	ACCUGAGGCCAUUGCACUC	2382	AccuGAGGccAuuGcAcucdTsdT	sense

1313-1332	2383	GAGUGCAAUGGCCUCAGGU	2384	GAGUGcAAUGGCCUcAGGUdTsdT	antis

1315-1334	2385	CUGAGGCCAUUGCACUCUG	2386	cuGAGGccAuuGcAcucuGdTsdT	sense

1315-1334	2387	CAGAGUGCAAUGGCCUCAG	2388	cAGAGUGcAAUGGCCUcAGdTsdT	antis

1322-1341	2389	CAUUGCACUCUGCUCUAGC	2390	cAuuGcAcucuGcucuAGcdTsdT	sense

1322-1341	2391	GCUAGAGCAGAGUGCAAUG	2392	GCuAGAGcAGAGUGcAAUGdTsdT	antis

1330-1349	2393	UCUGCUCUAGCCUACUGGA	2394	ucuGcucuAGccuAcuGGAdTsdT	sense

1330-1349	2395	UCCAGUAGGCUAGAGCAGA	2396	UCcAGuAGGCuAGAGcAGAdTsdT	antis

1344-1363	2397	CUGGAGUACACGCCAUCCU	2398	cuGGAGuAcAcGccAuccudTsdT	sense

1344-1363	2399	AGGAUGGCGUGUACUCCAG	2400	AGGAUGGCGUGuACUCcAGdTsdT	antis

1347-1366	2401	GAGUACACGCCAUCCUCAA	2402	GAGuAcAcGccAuccucAAdTsdT	sense

1347-1366	2403	UUGAGGAUGGCGUGUACUC	2404	UUGAGGAUGGCGUGuACUCdTsdT	antis

1350-1369	2405	UACACGCCAUCCUCAAGGC	2406	uAcAcGccAuccucAAGGcdTsdT	sense

1350-1369	2407	GCCUUGAGGAUGGCGUGUA	2408	GCCUUGAGGAUGGCGUGuAdTsdT	antis

1366-1385	2409	GGCUCUCCCCACUCGAGGC	2410	GGcucuccccAcucGAGGcdTsdT	sense

1366-1385	2411	GCCUCGAGUGGGGAGAGCC	2412	GCCUCGAGUGGGGAGAGCCdTsdT	antis

1367-1386	2413	GCUCUCCCCACUCGAGGCU	2414	GcucuccccAcucGAGGcudTsdT	sense

1367-1386	2415	AGCCUCGAGUGGGGAGAGC	2416	AGCCUCGAGUGGGGAGAGCdTsdT	antis

1368-1387	2417	CUCUCCCCACUCGAGGCUU	2418	cucuccccAcucGAGGcuudTsdT	sense

1368-1387	2419	AAGCCUCGAGUGGGGAGAG	2420	AAGCCUCGAGUGGGGAGAGdTsdT	antis

1403-1422	2421	CGAUGAACUGCGGAGACUC	2422	cGAuGAAcuGcGGAGAcucdTsdT	sense

1403-1422	2423	GAGUCUCCGCAGUUCAUCG	2424	GAGUCUCCGcAGUUcAUCGdTsdT	antis

1412-1431	2425	GCGGAGACUCGGAGCCCAG	2426	GcGGAGAcucGGAGcccAGdTsdT	sense

1412-1431	2427	CUGGGCUCCGAGUCUCCGC	2428	CUGGGCUCCGAGUCUCCGCdTsdT	antis

1413-1432	2429	CGGAGACUCGGAGCCCAGC	2430	cGGAGAcucGGAGcccAGcdTsdT	sense

1413-1432	2431	GCUGGGCUCCGAGUCUCCG	2432	GCUGGGCUCCGAGUCUCCGdTsdT	antis

1414-1433	2433	GGAGACUCGGAGCCCAGCU	2434	GGAGAcucGGAGcccAGcudTsdT	sense

1414-1433	2435	AGCUGGGCUCCGAGUCUCC	2436	AGCUGGGCUCCGAGUCUCCdTsdT	antis

1416-1435	2437	AGACUCGGAGCCCAGCUCC	2438	AGAcucGGAGcccAGcuccdTsdT	sense

1416-1435	2439	GGAGCUGGGCUCCGAGUCU	2440	GGAGCUGGGCUCCGAGUCUdTsdT	antis

1418-1437	2441	ACUCGGAGCCCAGCUCCCC	2442	AcucGGAGcccAGcuccccdTsdT	sense

1418-1437	2443	GGGGAGCUGGGCUCCGAGU	2444	GGGGAGCUGGGCUCCGAGUdTsdT	antis

1420-1439	2445	UCGGAGCCCAGCUCCCCAA	2446	ucGGAGcccAGcuccccAAdTsdT	sense

1420-1439	2447	UUGGGGAGCUGGGCUCCGA	2448	UUGGGGAGCUGGGCUCCGAdTsdT	antis

1438-1457	2449	ACGACCGCCCGCUUCCCCC	2450	AcGAccGcccGcuucccccdTsdT	sense

1438-1457	2451	GGGGGAAGCGGGCGGUCGU	2452	GGGGGAAGCGGGCGGUCGUdTsdT	antis

1447-1466	2453	CGCUUCCCCCCCUGUUCAA	2454	cGcuucccccccuGuucAAdTsdT	sense

1447-1466	2455	UUGAACAGGGGGGGAAGCG	2456	UUGAAcAGGGGGGGAAGCGdTsdT	antis

1471-1490	2457	GUCCUGGUGAACUGUCCAU	2458	GuccuGGuGAAcuGuccAudTsdT	sense

1471-1490	2459	AUGGACAGUUCACCAGGAC	2460	AUGGAcAGUUcACcAGGACdTsdT	antis

1476-1495	2461	GGUGAACUGUCCAUCCAAC	2462	GGuGAAcuGuccAuccAAcdTsdT	sense

1476-1495	2463	GUUGGAUGGACAGUUCACC	2464	GUUGGAUGGAcAGUUcACCdTsdT	antis

1477-1496	2465	GUGAACUGUCCAUCCAACC	2466	GuGAAcuGuccAuccAAccdTsdT	sense

1477-1496	2467	GGUUGGAUGGACAGUUCAC	2468	GGUUGGAUGGAcAGUUcACdTsdT	antis

1486-1505	2469	CCAUCCAACCAUCUCUCAA	2470	ccAuccAAccAucucucAAdTsdT	sense

1486-1505	2471	UUGAGAGAUGGUUGGAUGG	2472	UUGAGAGAUGGUUGGAUGGdTsdT	antis

1487-1506	2473	CAUCCAACCAUCUCUCAAU	2474	cAuccAAccAucucucAAudTsdT	sense

1487-1506	2475	AUUGAGAGAUGGUUGGAUG	2476	AUUGAGAGAUGGUUGGAUGdTsdT	antis

1491-1510	2477	CAACCAUCUCUCAAUGCCA	2478	cAAccAucucucAAuGccAdTsdT	sense

1491-1510	2479	UGGCAUUGAGAGAUGGUUG	2480	UGGcAUUGAGAGAUGGUUGdTsdT	antis

1492-1511	2481	AACCAUCUCUCAAUGCCAU	2482	AAccAucucucAAuGccAudTsdT	sense

1492-1511	2483	AUGGCAUUGAGAGAUGGUU	2484	AUGGcAUUGAGAGAUGGUUdTsdT	antis

1493-1512	2485	ACCAUCUCUCAAUGCCAUU	2486	AccAucucucAAuGccAuudTsdT	sense

1493-1512	2487	AAUGGCAUUGAGAGAUGGU	2488	AAUGGcAUUGAGAGAUGGUdTsdT	antis

1551-1570	2489	UCUCCCCUCACCACUUCCU	2490	ucuccccucAccAcuuccudTsdT	sense

1551-1570	2491	AGGAAGUGGUGAGGGGAGA	2492	AGGAAGUGGUGAGGGGAGAdTsdT	antis

1553-1572	2493	UCCCCUCACCACUUCCUAC	2494	uccccucAccAcuuccuAcdTsdT	sense

1553-1572	2495	GUAGGAAGUGGUGAGGGGA	2496	GuAGGAAGUGGUGAGGGGAdTsdT	antis

1556-1575	2497	CCUCACCACUUCCUACAAC	2498	ccucAccAcuuccuAcAAcdTsdT	sense

1556-1575	2499	GUUGUAGGAAGUGGUGAGG	2500	GUUGuAGGAAGUGGUGAGGdTsdT	antis

1560-1579	2501	ACCACUUCCUACAACCCAU	2502	AccAcuuccuAcAAcccAudTsdT	sense

1560-1579	2503	AUGGGUUGUAGGAAGUGGU	2504	AUGGGUUGuAGGAAGUGGUdTsdT	antis

1561-1580	2505	CCACUUCCUACAACCCAUC	2506	ccAcuuccuAcAAcccAucdTsdT	sense

1561-1580	2507	GAUGGGUUGUAGGAAGUGG	2508	GAUGGGUUGuAGGAAGUGGdTsdT	antis

1562-1581	2509	CACUUCCUACAACCCAUCC	2510	cAcuuccuAcAAcccAuccdTsdT	sense

1562-1581	2511	GGAUGGGUUGUAGGAAGUG	2512	GGAUGGGUUGuAGGAAGUGdTsdT	antis

1564-1583	2513	CUUCCUACAACCCAUCCUC	2514	cuuccuAcAAcccAuccucdTsdT	sense

1564-1583	2515	GAGGAUGGGUUGUAGGAAG	2516	GAGGAUGGGUUGuAGGAAGdTsdT	antis

1565-1584	2517	UUCCUACAACCCAUCCUCA	2518	uuccuAcAAcccAuccucAdTsdT	sense

1565-1584	2519	UGAGGAUGGGUUGUAGGAA	2520	UGAGGAUGGGUUGuAGGAAdTsdT	antis

1568-1587	2521	CUACAACCCAUCCUCACAA	2522	cuAcAAcccAuccucAcAAdTsdT	sense

1568-1587	2523	UUGUGAGGAUGGGUUGUAG	2524	UUGUGAGGAUGGGUUGuAGdTsdT	antis

1569-1588	2525	UACAACCCAUCCUCACAAG	2526	uAcAAcccAuccucAcAAGdTsdT	sense

1569-1588	2527	CUUGUGAGGAUGGGUUGUA	2528	CUUGUGAGGAUGGGUUGuAdTsdT	antis

1572-1591	2529	AACCCAUCCUCACAAGCUU	2530	AAcccAuccucAcAAGcuudTsdT	sense

1572-1591	2531	AAGCUUGUGAGGAUGGGUU	2532	AAGCUUGUGAGGAUGGGUUdTsdT	antis

1573-1592	2533	ACCCAUCCUCACAAGCUUU	2534	AcccAuccucAcAAGcuuudTsdT	sense

1573-1592	2535	AAAGCUUGUGAGGAUGGGU	2536	AAAGCUUGUGAGGAUGGGUdTsdT	antis

1590-1609	2537	UUAACUGAAGCUCAGACUG	2538	uuAAcuGAAGcucAGAcuGdTsdT	sense

1590-1609	2539	CAGUCUGAGCUUCAGUUAA	2540	cAGUCUGAGCUUcAGUuAAdTsdT	antis

1591-1610	2541	UAACUGAAGCUCAGACUGG	2542	uAAcuGAAGcucAGAcuGGdTsdT	sense

1591-1610	2543	CCAGUCUGAGCUUCAGUUA	2544	CcAGUCUGAGCUUcAGUuAdTsdT	antis

1592-1611	2545	AACUGAAGCUCAGACUGGC	2546	AAcuGAAGcucAGAcuGGcdTsdT	sense

1592-1611	2547	GCCAGUCUGAGCUUCAGUU	2548	GCcAGUCUGAGCUUcAGUUdTsdT	antis

1593-1612	2549	ACUGAAGCUCAGACUGGCC	2550	AcuGAAGcucAGAcuGGccdTsdT	sense

1593-1612	2551	GGCCAGUCUGAGCUUCAGU	2552	GGCcAGUCUGAGCUUcAGUdTsdT	antis

1595-1614	2553	UGAAGCUCAGACUGGCCAA	2554	uGAAGcucAGAcuGGccAAdTsdT	sense

1595-1614	2555	UUGGCCAGUCUGAGCUUCA	2556	UUGGCcAGUCUGAGCUUcAdTsdT	antis

1601-1620	2557	UCAGACUGGCCAAGAUUGG	2558	ucAGAcuGGccAAGAuuGGdTsdT	sense

1601-1620	2559	CCAAUCUUGGCCAGUCUGA	2560	CcAAUCUUGGCcAGUCUGAdTsdT	antis

1606-1625	2561	CUGGCCAAGAUUGGCAGCC	2562	cuGGccAAGAuuGGcAGccdTsdT	sense

1606-1625	2563	GGCUGCCAAUCUUGGCCAG	2564	GGCUGCcAAUCUUGGCcAGdTsdT	antis

1610-1629	2565	CCAAGAUUGGCAGCCAUCU	2566	ccAAGAuuGGcAGccAucudTsdT	sense

1610-1629	2567	AGAUGGCUGCCAAUCUUGG	2568	AGAUGGCUGCcAAUCUUGGdTsdT	antis

1614-1633	2569	GAUUGGCAGCCAUCUGAUG	2570	GAuuGGcAGccAucuGAuGdTsdT	sense

1614-1633	2571	CAUCAGAUGGCUGCCAAUC	2572	cAUcAGAUGGCUGCcAAUCdTsdT	antis

1650-1669	2573	GCUAGCUCUUCCUGAGGGC	2574	GcuAGcucuuccuGAGGGcdTsdT	sense

1650-1669	2575	GCCCUCAGGAAGAGCUAGC	2576	GCCCUcAGGAAGAGCuAGCdTsdT	antis

1654-1673	2577	GCUCUUCCUGAGGGCCCCA	2578	GcucuuccuGAGGGccccAdTsdT	sense

1654-1673	2579	UGGGGCCCUCAGGAAGAGC	2580	UGGGGCCCUcAGGAAGAGCdTsdT	antis

1657-1676	2581	CUUCCUGAGGGCCCCACCG	2582	cuuccuGAGGGccccAccGdTsdT	sense

1657-1676	2583	CGGUGGGGCCCUCAGGAAG	2584	CGGUGGGGCCCUcAGGAAGdTsdT	antis

1799-1818	2585	CAUCUAGGCCUCCCUCAGC	2586	cAucuAGGccucccucAGcdTsdT	sense

1799-1818	2587	GCUGAGGGAGGCCUAGAUG	2588	GCUGAGGGAGGCCuAGAUGdTsdT	antis

1801-1820	2589	UCUAGGCCUCCCUCAGCAG	2590	ucuAGGccucccucAGcAGdTsdT	sense

1801-1820	2591	CUGCUGAGGGAGGCCUAGA	2592	CUGCUGAGGGAGGCCuAGAdTsdT	antis

1839-1858	2593	UUUUUAAAGAGGAUUUUAA	2594	uuuuuAAAGAGGAuuuuAAdTsdT	sense

1839-1858	2595	UUAAAAUCCUCUUUAAAAA	2596	UuAAAAUCCUCUUuAAAAAdTsdT	antis

1840-1859	2597	UUUUAAAGAGGAUUUUAAC	2598	uuuuAAAGAGGAuuuuAAcdTsdT	sense

1840-1859	2599	GUUAAAAUCCUCUUUAAAA	2600	GUuAAAAUCCUCUUuAAAAdTsdT	antis

1841-1860	2601	UUUAAAGAGGAUUUUAACU	2602	uuuAAAGAGGAuuuuAAcudTsdT	sense

1841-1860	2603	AGUUAAAAUCCUCUUUAAA	2604	AGUuAAAAUCCUCUUuAAAdTsdT	antis

1842-1861	2605	UUAAAGAGGAUUUUAACUG	2606	uuAAAGAGGAuuuuAAcuGdTsdT	sense

1842-1861	2607	CAGUUAAAAUCCUCUUUAA	2608	cAGUuAAAAUCCUCUUuAAdTsdT	antis

1843-1862	2609	UAAAGAGGAUUUUAACUGU	2610	uAAAGAGGAuuuuAAcuGudTsdT	sense

1843-1862	2611	ACAGUUAAAAUCCUCUUUA	2612	AcAGUuAAAAUCCUCUUuAdTsdT	antis

1845-1864	2613	AAGAGGAUUUUAACUGUUU	2614	AAGAGGAuuuuAAcuGuuudTsdT	sense

1845-1864	2615	AAACAGUUAAAAUCCUCUU	2616	AAAcAGUuAAAAUCCUCUUdTsdT	antis

1849-1868	2617	GGAUUUUAACUGUUUGUAG	2618	GGAuuuuAAcuGuuuGuAGdTsdT	sense

1849-1868	2619	CUACAAACAGUUAAAAUCC	2620	CuAcAAAcAGUuAAAAUCCdTsdT	antis

1858-1877	2621	CUGUUUGUAGGGGAGGGGA	2622	cuGuuuGuAGGGGAGGGGAdTsdT	sense

1858-1877	2623	UCCCCUCCCCUACAAACAG	2624	UCCCCUCCCCuAcAAAcAGdTsdT	antis

1859-1878	2625	UGUUUGUAGGGGAGGGGAG	2626	uGuuuGuAGGGGAGGGGAGdTsdT	sense

1859-1878	2627	CUCCCCUCCCCUACAAACA	2628	CUCCCCUCCCCuAcAAAcAdTsdT	antis

1862-1881	2629	UUGUAGGGGAGGGGAGAAA	2630	uuGuAGGGGAGGGGAGAAAdTsdT	sense

1862-1881	2631	UUUCUCCCCUCCCCUACAA	2632	UUUCUCCCCUCCCCuAcAAdTsdT	antis

1863-1882	2633	UGUAGGGGAGGGGAGAAAA	2634	uGuAGGGGAGGGGAGAAAAdTsdT	sense

1863-1882	2635	UUUUCUCCCCUCCCCUACA	2636	UUUUCUCCCCUCCCCuAcAdTsdT	antis

1874-1893	2637	GGAGAAAAGGAAGGACGGG	2638	GGAGAAAAGGAAGGAcGGGdTsdT	sense

1874-1893	2639	CCCGUCCUUCCUUUUCUCC	2640	CCCGUCCUUCCUUUUCUCCdTsdT	antis

1875-1894	2641	GAGAAAAGGAAGGACGGGG	2642	GAGAAAAGGAAGGAcGGGGdTsdT	sense

1875-1894	2643	CCCCGUCCUUCCUUUUCUC	2644	CCCCGUCCUUCCUUUUCUCdTsdT	antis

1876-1895	2645	AGAAAAGGAAGGACGGGGU	2646	AGAAAAGGAAGGAcGGGGudTsdT	sense

1876-1895	2647	ACCCCGUCCUUCCUUUUCU	2648	ACCCCGUCCUUCCUUUUCUdTsdT	antis

1878-1897	2649	AAAAGGAAGGACGGGGUUU	2650	AAAAGGAAGGAcGGGGuuudTsdT	sense

1878-1897	2651	AAACCCCGUCCUUCCUUUU	2652	AAACCCCGUCCUUCCUUUUdTsdT	antis

1898-1917	2653	GGGGUGUGAGGACCUUCUA	2654	GGGGuGuGAGGAccuucuAdTsdT	sense

1898-1917	2655	UAGAAGGUCCUCACACCCC	2656	uAGAAGGUCCUcAcACCCCdTsdT	antis

1899-1918	2657	GGGUGUGAGGACCUUCUAC	2658	GGGuGuGAGGAccuucuAcdTsdT	sense

1899-1918	2659	GUAGAAGGUCCUCACACCC	2660	GuAGAAGGUCCUcAcACCCdTsdT	antis

1900-1919	2661	GGUGUGAGGACCUUCUACC	2662	GGuGuGAGGAccuucuAccdTsdT	sense

1900-1919	2663	GGUAGAAGGUCCUCACACC	2664	GGuAGAAGGUCCUcAcACCdTsdT	antis

1902-1921	2665	UGUGAGGACCUUCUACCCC	2666	uGuGAGGAccuucuAccccdTsdT	sense

1902-1921	2667	GGGGUAGAAGGUCCUCACA	2668	GGGGuAGAAGGUCCUcAcAdTsdT	antis

1903-1922	2669	GUGAGGACCUUCUACCCCC	2670	GuGAGGAccuucuAcccccdTsdT	sense

1903-1922	2671	GGGGGUAGAAGGUCCUCAC	2672	GGGGGuAGAAGGUCCUcACdTsdT	antis

1959-1978	2673	CUCCCCCCCUCUCCCAGGU	2674	cucccccccucucccAGGudTsdT	sense

1959-1978	2675	ACCUGGGAGAGGGGGGGAG	2676	ACCUGGGAGAGGGGGGGAGdTsdT	antis

1964-1983	2677	CCCCUCUCCCAGGUCCCUU	2678	ccccucucccAGGucccuudTsdT	sense

1964-1983	2679	AAGGGACCUGGGAGAGGGG	2680	AAGGGACCUGGGAGAGGGGdTsdT	antis

1970-1989	2681	UCCCAGGUCCCUUGUAAAU	2682	ucccAGGucccuuGuAAAudTsdT	sense

1970-1989	2683	AUUUACAAGGGACCUGGGA	2684	AUUuAcAAGGGACCUGGGAdTsdT	antis

1974-1993	2685	AGGUCCCUUGUAAAUAGAA	2686	AGGucccuuGuAAAuAGAAdTsdT	sense

1974-1993	2687	UUCUAUUUACAAGGGACCU	2688	UUCuAUUuAcAAGGGACCUdTsdT	antis

1983-2002	2689	GUAAAUAGAACCAGCCCAG	2690	GuAAAuAGAAccAGcccAGdTsdT	sense

1983-2002	2691	CUGGGCUGGUUCUAUUUAC	2692	CUGGGCUGGUUCuAUUuACdTsdT	antis

1984-2003	2693	UAAAUAGAACCAGCCCAGC	2694	uAAAuAGAAccAGcccAGcdTsdT	sense

1984-2003	2695	GCUGGGCUGGUUCUAUUUA	2696	GCUGGGCUGGUUCuAUUuAdTsdT	antis

1994-2013	2697	CAGCCCAGCCCAUCUCUCG	2698	cAGcccAGcccAucucucGdTsdT	sense

1994-2013	2699	CGAGAGAUGGGCUGGGCUG	2700	CGAGAGAUGGGCUGGGCUGdTsdT	antis

1995-2014	2701	AGCCCAGCCCAUCUCUCGU	2702	AGcccAGcccAucucucGudTsdT	sense

1995-2014	2703	ACGAGAGAUGGGCUGGGCU	2704	ACGAGAGAUGGGCUGGGCUdTsdT	antis

1996-2015	2705	GCCCAGCCCAUCUCUCGUC	2706	GcccAGcccAucucucGucdTsdT	sense

1996-2015	2707	GACGAGAGAUGGGCUGGGC	2708	GACGAGAGAUGGGCUGGGCdTsdT	antis

1998-2017	2709	CCAGCCCAUCUCUCGUCUU	2710	ccAGcccAucucucGucuudTsdT	sense

1998-2017	2711	AAGACGAGAGAUGGGCUGG	2712	AAGACGAGAGAUGGGCUGGdTsdT	antis

2016-2035	2713	UCCCUUCCCUGGCCCCCUG	2714	ucccuucccuGGcccccuGdTsdT	sense

2016-2035	2715	CAGGGGGCCAGGGAAGGGA	2716	cAGGGGGCcAGGGAAGGGAdTsdT	antis

2022-2041	2717	CCCUGGCCCCCUGGGUGUA	2718	cccuGGcccccuGGGuGuAdTsdT	sense

2022-2041	2719	UACACCCAGGGGGCCAGGG	2720	uAcACCcAGGGGGCcAGGGdTsdT	antis

2025-2044	2721	UGGCCCCCUGGGUGUAAAU	2722	uGGcccccuGGGuGuAAAudTsdT	sense

2025-2044	2723	AUUUACACCCAGGGGGCCA	2724	AUUuAcACCcAGGGGGCcAdTsdT	antis

2026-2045	2725	GGCCCCCUGGGUGUAAAUA	2726	GGcccccuGGGuGuAAAuAdTsdT	sense

2026-2045	2727	UAUUUACACCCAGGGGGCC	2728	uAUUuAcACCcAGGGGGCCdTsdT	antis

2035-2054	2729	GGUGUAAAUAGAUUGUUAU	2730	GGuGuAAAuAGAuuGuuAudTsdT	sense

2035-2054	2731	AUAACAAUCUAUUUACACC	2732	AuAAcAAUCuAUUuAcACCdTsdT	antis

2041-2060	2733	AAUAGAUUGUUAUAAUUUU	2734	AAuAGAuuGuuAuAAuuuudTsdT	sense

2041-2060	2735	AAAAUUAUAACAAUCUAUU	2736	AAAAUuAuAAcAAUCuAUUdTsdT	antis

2047-2066	2737	UUGUUAUAAUUUUUUCUUA	2738	uuGuuAuAAuuuuuucuuAdTsdT	sense

2047-2066	2739	UAAGAAAAAAUUAUAACAA	2740	uAAGAAAAAAUuAuAAcAAdTsdT	antis

2057-2076	2741	UUUUUCUUAAAGAAAACGU	2742	uuuuucuuAAAGAAAAcGudTsdT	sense

2057-2076	2743	ACGUUUUCUUUAAGAAAAA	2744	ACGUUUUCUUuAAGAAAAAdTsdT	antis

2058-2077	2745	UUUUCUUAAAGAAAACGUC	2746	uuuucuuAAAGAAAAcGucdTsdT	sense

2058-2077	2747	GACGUUUUCUUUAAGAAAA	2748	GACGUUUUCUUuAAGAAAAdTsdT	antis

2060-2079	2749	UUCUUAAAGAAAACGUCAA	2750	uucuuAAAGAAAAcGucAAdTsdT	sense

2060-2079	2751	UUGACGUUUUCUUUAAGAA	2752	UUGACGUUUUCUUuAAGAAdTsdT	antis

2066-2085	2753	AAGAAAACGUCAAUUCACA	2754	AAGAAAAcGucAAuucAcAdTsdT	sense

2066-2085	2755	UGUGAAUUGACGUUUUCUU	2756	UGUGAAUUGACGUUUUCUUdTsdT	antis

2075-2094	2757	UCAAUUCACACCAUUCAAC	2758	ucAAuucAcAccAuucAAcdTsdT	sense

2075-2094	2759	GUUGAAUGGUGUGAAUUGA	2760	GUUGAAUGGUGUGAAUUGAdTsdT	antis

2077-2096	2761	AAUUCACACCAUUCAACUU	2762	AAuucAcAccAuucAAcuudTsdT	sense

2077-2096	2763	AAGUUGAAUGGUGUGAAUU	2764	AAGUUGAAUGGUGUGAAUUdTsdT	antis

2079-2098	2765	UUCACACCAUUCAACUUGC	2766	uucAcAccAuucAAcuuGcdTsdT	sense

2079-2098	2767	GCAAGUUGAAUGGUGUGAA	2768	GcAAGUUGAAUGGUGUGAAdTsdT	antis

2081-2100	2769	CACACCAUUCAACUUGCCC	2770	cAcAccAuucAAcuuGcccdTsdT	sense

2081-2100	2771	GGGCAAGUUGAAUGGUGUG	2772	GGGcAAGUUGAAUGGUGUGdTsdT	antis

2091-2110	2773	AACUUGCCCCCCCCAGCUG	2774	AAcuuGccccccccAGcuGdTsdT	sense

2091-2110	2775	CAGCUGGGGGGGGCAAGUU	2776	cAGCUGGGGGGGGcAAGUUdTsdT	antis

2092-2111	2777	ACUUGCCCCCCCCAGCUGU	2778	AcuuGccccccccAGcuGudTsdT	sense

2092-2111	2779	ACAGCUGGGGGGGGCAAGU	2780	AcAGCUGGGGGGGGcAAGUdTsdT	antis

2096-2115	2781	GCCCCCCCCAGCUGUACCC	2782	GccccccccAGcuGuAcccdTsdT	sense

2096-2115	2783	GGGUACAGCUGGGGGGGGC	2784	GGGuAcAGCUGGGGGGGGCdTsdT	antis

2097-2116	2785	CCCCCCCCAGCUGUACCCC	2786	ccccccccAGcuGuAccccdTsdT	sense

2097-2116	2787	GGGGUACAGCUGGGGGGGG	2788	GGGGuAcAGCUGGGGGGGGdTsdT	antis

2098-2117	2789	CCCCCCCAGCUGUACCCCU	2790	cccccccAGcuGuAccccudTsdT	sense

2098-2117	2791	AGGGGUACAGCUGGGGGGG	2792	AGGGGuAcAGCUGGGGGGGdTsdT	antis

2099-2118	2793	CCCCCCAGCUGUACCCCUU	2794	ccccccAGcuGuAccccuudTsdT	sense

2099-2118	2795	AAGGGGUACAGCUGGGGGG	2796	AAGGGGuAcAGCUGGGGGGdTsdT	antis

2100-2119	2797	CCCCCAGCUGUACCCCUUC	2798	cccccAGcuGuAccccuucdTsdT	sense

2100-2119	2799	GAAGGGGUACAGCUGGGGG	2800	GAAGGGGuAcAGCUGGGGGdTsdT	antis

2107-2126	2801	CUGUACCCCUUCUUGUCCU	2802	cuGuAccccuucuuGuccudTsdT	sense

2107-2126	2803	AGGACAAGAAGGGGUACAG	2804	AGGAcAAGAAGGGGuAcAGdTsdT	antis

2108-2127	2805	UGUACCCCUUCUUGUCCUC	2806	uGuAccccuucuuGuccucdTsdT	sense

2108-2127	2807	GAGGACAAGAAGGGGUACA	2808	GAGGAcAAGAAGGGGuAcAdTsdT	antis

2123-2142	2809	CCUCUGCUCCCAAGGCUUC	2810	ccucuGcucccAAGGcuucdTsdT	sense

2123-2142	2811	GAAGCCUUGGGAGCAGAGG	2812	GAAGCCUUGGGAGcAGAGGdTsdT	antis

2124-2143	2813	CUCUGCUCCCAAGGCUUCC	2814	cucuGcucccAAGGcuuccdTsdT	sense

2124-2143	2815	GGAAGCCUUGGGAGCAGAG	2816	GGAAGCCUUGGGAGcAGAGdTsdT	antis

2151-2170	2817	CCCAUCCUGGAAGGAGGGG	2818	cccAuccuGGAAGGAGGGGdTsdT	sense

2151-2170	2819	CCCCUCCUUCCAGGAUGGG	2820	CCCCUCCUUCcAGGAUGGGdTsdT	antis

2157-2176	2821	CUGGAAGGAGGGGAGUAGA	2822	cuGGAAGGAGGGGAGuAGAdTsdT	sense

2157-2176	2823	UCUACUCCCCUCCUUCCAG	2824	UCuACUCCCCUCCUUCcAGdTsdT	antis

2158-2177	2825	UGGAAGGAGGGGAGUAGAG	2826	uGGAAGGAGGGGAGuAGAGdTsdT	sense

2158-2177	2827	CUCUACUCCCCUCCUUCCA	2828	CUCuACUCCCCUCCUUCcAdTsdT	antis

2159-2178	2829	GGAAGGAGGGGAGUAGAGA	2830	GGAAGGAGGGGAGuAGAGAdTsdT	sense

2159-2178	2831	UCUCUACUCCCCUCCUUCC	2832	UCUCuACUCCCCUCCUUCCdTsdT	antis

2160-2179	2833	GAAGGAGGGGAGUAGAGAG	2834	GAAGGAGGGGAGuAGAGAGdTsdT	sense

2160-2179	2835	CUCUCUACUCCCCUCCUUC	2836	CUCUCuACUCCCCUCCUUCdTsdT	antis

2165-2184	2837	AGGGGAGUAGAGAGAGUCC	2838	AGGGGAGuAGAGAGAGuccdTsdT	sense

2165-2184	2839	GGACUCUCUCUACUCCCCU	2840	GGACUCUCUCuACUCCCCUdTsdT	antis

2166-2185	2841	GGGGAGUAGAGAGAGUCCC	2842	GGGGAGuAGAGAGAGucccdTsdT	sense

2166-2185	2843	GGGACUCUCUCUACUCCCC	2844	GGGACUCUCUCuACUCCCCdTsdT	antis

2169-2188	2845	GAGUAGAGAGAGUCCCUGG	2846	GAGuAGAGAGAGucccuGGdTsdT	sense

2169-2188	2847	CCAGGGACUCUCUCUACUC	2848	CcAGGGACUCUCUCuACUCdTsdT	antis

2173-2192	2849	AGAGAGAGUCCCUGGUGUC	2850	AGAGAGAGucccuGGuGucdTsdT	sense

2173-2192	2851	GACACCAGGGACUCUCUCU	2852	GAcACcAGGGACUCUCUCUdTsdT	antis

2178-2197	2853	GAGUCCCUGGUGUCUUAGU	2854	GAGucccuGGuGucuuAGudTsdT	sense

2178-2197	2855	ACUAAGACACCAGGGACUC	2856	ACuAAGAcACcAGGGACUCdTsdT	antis

2179-2198	2857	AGUCCCUGGUGUCUUAGUU	2858	AGucccuGGuGucuuAGuudTsdT	sense

2179-2198	2859	AACUAAGACACCAGGGACU	2860	AACuAAGAcACcAGGGACUdTsdT	antis

2182-2201	2861	CCCUGGUGUCUUAGUUUCC	2862	cccuGGuGucuuAGuuuccdTsdT	sense

2182-2201	2863	GGAAACUAAGACACCAGGG	2864	GGAAACuAAGAcACcAGGGdTsdT	antis

2183-2202	2865	CCUGGUGUCUUAGUUUCCA	2866	ccuGGuGucuuAGuuuccAdTsdT	sense

2183-2202	2867	UGGAAACUAAGACACCAGG	2868	UGGAAACuAAGAcACcAGGdTsdT	antis

2188-2207	2869	UGUCUUAGUUUCCACAGUA	2870	uGucuuAGuuuccAcAGuAdTsdT	sense

2188-2207	2871	UACUGUGGAAACUAAGACA	2872	uACUGUGGAAACuAAGAcAdTsdT	antis

2198-2217	2873	UCCACAGUAAGGUUUGCCU	2874	uccAcAGuAAGGuuuGccudTsdT	sense

2198-2217	2875	AGGCAAACCUUACUGUGGA	2876	AGGcAAACCUuACUGUGGAdTsdT	antis

2199-2218	2877	CCACAGUAAGGUUUGCCUG	2878	ccAcAGuAAGGuuuGccuGdTsdT	sense

2199-2218	2879	CAGGCAAACCUUACUGUGG	2880	cAGGcAAACCUuACUGUGGdTsdT	antis

2200-2219	2881	CACAGUAAGGUUUGCCUGU	2882	cAcAGuAAGGuuuGccuGudTsdT	sense

2200-2219	2883	ACAGGCAAACCUUACUGUG	2884	AcAGGcAAACCUuACUGUGdTsdT	antis

2201-2220	2885	ACAGUAAGGUUUGCCUGUG	2886	AcAGuAAGGuuuGccuGuGdTsdT	sense

2201-2220	2887	CACAGGCAAACCUUACUGU	2888	cAcAGGcAAACCUuACUGUdTsdT	antis

2203-2222	2889	AGUAAGGUUUGCCUGUGUA	2890	AGuAAGGuuuGccuGuGuAdTsdT	sense

2203-2222	2891	UACACAGGCAAACCUUACU	2892	uAcAcAGGcAAACCUuACUdTsdT	antis

2204-2223	2893	GUAAGGUUUGCCUGUGUAC	2894	GuAAGGuuuGccuGuGuAcdTsdT	sense

2204-2223	2895	GUACACAGGCAAACCUUAC	2896	GuAcAcAGGcAAACCUuACdTsdT	antis

2205-2224	2897	UAAGGUUUGCCUGUGUACA	2898	uAAGGuuuGccuGuGuAcAdTsdT	sense

2205-2224	2899	UGUACACAGGCAAACCUUA	2900	UGuAcAcAGGcAAACCUuAdTsdT	antis

2210-2229	2901	UUUGCCUGUGUACAGACCU	2902	uuuGccuGuGuAcAGAccudTsdT	sense

2210-2229	2903	AGGUCUGUACACAGGCAAA	2904	AGGUCUGuAcAcAGGcAAAdTsdT	antis

2211-2230	2905	UUGCCUGUGUACAGACCUC	2906	uuGccuGuGuAcAGAccucdTsdT	sense

2211-2230	2907	GAGGUCUGUACACAGGCAA	2908	GAGGUCUGuAcAcAGGcAAdTsdT	antis

2214-2233	2909	CCUGUGUACAGACCUCUGU	2910	ccuGuGuAcAGAccucuGudTsdT	sense

2214-2233	2911	ACAGAGGUCUGUACACAGG	2912	AcAGAGGUCUGuAcAcAGGdTsdT	antis

2215-2234	2913	CUGUGUACAGACCUCUGUU	2914	cuGuGuAcAGAccucuGuudTsdT	sense

2215-2234	2915	AACAGAGGUCUGUACACAG	2916	AAcAGAGGUCUGuAcAcAGdTsdT	antis

2220-2239	2917	UACAGACCUCUGUUCAAUA	2918	uAcAGAccucuGuucAAuAdTsdT	sense

2220-2239	2919	UAUUGAACAGAGGUCUGUA	2920	uAUUGAAcAGAGGUCUGuAdTsdT	antis

2224-2243	2921	GACCUCUGUUCAAUAAAUU	2922	GAccucuGuucAAuAAAuudTsdT	sense

2224-2243	2923	AAUUUAUUGAACAGAGGUC	2924	AAUUuAUUGAAcAGAGGUCdTsdT	antis

2234-2253	2925	CAAUAAAUUAUUGGCAUGA	2926	cAAuAAAuuAuuGGcAuGAdTsdT	sense

2234-2253	2927	UCAUGCCAAUAAUUUAUUG	2928	UcAUGCcAAuAAUUuAUUGdTsdT	antis

51-70	2929	CGCGGCGGGCGCUGGGCCG	2930	cGcGGcGGGcGcuGGGccGdTsdT	sense

51-70	2931	CGGCCCAGCGCCCGCCGCG	2932	CGGCCcAGCGCCCGCCGCGdTsdT	antis

173-192	2933	UGGGCCUGCGCUCGGCGCC	2934	uGGGccuGcGcucGGcGccdTsdT	sense

173-192	2935	GGCGCCGAGCGCAGGCCCA	2936	GGCGCCGAGCGcAGGCCcAdTsdT	antis

205-224	2937	GGCCUUCGGGAGGCGGCCC	2938	GGccuucGGGAGGcGGcccdTsdT	sense

205-224	2939	GGGCCGCCUCCCGAAGGCC	2940	GGGCCGCCUCCCGAAGGCCdTsdT	antis

221-240	2941	CCCUGGGGGCUCGGGCCGG	2942	cccuGGGGGcucGGGccGGdTsdT	sense

221-240	2943	CCGGCCCGAGCCCCCAGGG	2944	CCGGCCCGAGCCCCcAGGGdTsdT	antis

224-243	2945	UGGGGGCUCGGGCCGGGCG	2946	uGGGGGcucGGGccGGGcGdTsdT	sense

224-243	2947	CGCCCGGCCCGAGCCCCCA	2948	CGCCCGGCCCGAGCCCCcAdTsdT	antis

387-406	2949	GGGGGUGGCCCCAGCGGCA	2950	GGGGGuGGccccAGcGGcAdTsdT	sense

387-406	2951	UGCCGCUGGGGCCACCCCC	2952	UGCCGCUGGGGCcACCCCCdTsdT	antis

392-411	2953	UGGCCCCAGCGGCAGCGGC	2954	uGGccccAGcGGcAGcGGcdTsdT	sense

392-411	2955	GCCGCUGCCGCUGGGGCCA	2956	GCCGCUGCCGCUGGGGCcAdTsdT	antis

465-484	2957	AAGCUGGGCCGUGACAGCG	2958	AAGcuGGGccGuGAcAGcGdTsdT	sense

465-484	2959	CGCUGUCACGGCCCAGCUU	2960	CGCUGUcACGGCCcAGCUUdTsdT	antis

505-524	2961	CCACUGUAGGCCAAGGCCC	2962	ccAcuGuAGGccAAGGcccdTsdT	sense

505-524	2963	GGGCCUUGGCCUACAGUGG	2964	GGGCCUUGGCCuAcAGUGGdTsdT	antis

587-606	2965	AGUAUACCAGGCACGGCUG	2966	AGuAuAccAGGcAcGGcuGdTsdT	sense

587-606	2967	CAGCCGUGCCUGGUAUACU	2968	cAGCCGUGCCUGGuAuACUdTsdT	antis

601-620	2969	GGCUGGCAGAGACGAGGGA	2970	GGcuGGcAGAGAcGAGGGAdTsdT	sense

601-620	2971	UCCCUCGUCUCUGCCAGCC	2972	UCCCUCGUCUCUGCcAGCCdTsdT	antis

743-762	2973	GAAGAAGGACGAGCUGUAU	2974	GAAGAAGGAcGAGcuGuAudTsdT	sense

743-762	2975	AUACAGCUCGUCCUUCUUC	2976	AuAcAGCUCGUCCUUCUUCdTsdT	antis

927-946	2977	AAGCCCCAGAAUUUGCUUG	2978	AAGccccAGAAuuuGcuuGdTsdT	sense

927-946	2979	CAAGCAAAUUCUGGGGCUU	2980	cAAGcAAAUUCUGGGGCUUdTsdT	antis

932-951	2981	CCAGAAUUUGCUUGUGGAC	2982	ccAGAAuuuGcuuGuGGAcdTsdT	sense

932-951	2983	GUCCACAAGCAAAUUCUGG	2984	GUCcAcAAGcAAAUUCUGGdTsdT	antis

1054-1073	2985	CAGAACUCAUCUUUGGAGC	2986	cAGAAcucAucuuuGGAGcdTsdT	sense

1054-1073	2987	GCUCCAAAGAUGAGUUCUG	2988	GCUCcAAAGAUGAGUUCUGdTsdT	antis

1060-1079	2989	UCAUCUUUGGAGCCACAGA	2990	ucAucuuuGGAGccAcAGAdTsdT	sense

1060-1079	2991	UCUGUGGCUCCAAAGAUGA	2992	UCUGUGGCUCcAAAGAUGAdTsdT	antis

1068-1087	2993	GGAGCCACAGAUUACACCU	2994	GGAGccAcAGAuuAcAccudTsdT	sense

1068-1087	2995	AGGUGUAAUCUGUGGCUCC	2996	AGGUGuAAUCUGUGGCUCCdTsdT	antis

1094-1113	2997	CGAUGUGUGGUCGGCUGGC	2998	cGAuGuGuGGucGGcuGGcdTsdT	sense

1094-1113	2999	GCCAGCCGACCACACAUCG	3000	GCcAGCCGACcAcAcAUCGdTsdT	antis

1107-1126	3001	GCUGGCUGUGUACUUGCUG	3002	GcuGGcuGuGuAcuuGcuGdTsdT	sense

1107-1126	3003	CAGCAAGUACACAGCCAGC	3004	cAGcAAGuAcAcAGCcAGCdTsdT	antis

1108-1127	3005	CUGGCUGUGUACUUGCUGA	3006	cuGGcuGuGuAcuuGcuGAdTsdT	sense

1108-1127	3007	UCAGCAAGUACACAGCCAG	3008	UcAGcAAGuAcAcAGCcAGdTsdT	antis

1138-1157	3009	GCCAGCCCAUCUUCCCUGG	3010	GccAGcccAucuucccuGGdTsdT	sense

1138-1157	3011	CCAGGGAAGAUGGGCUGGC	3012	CcAGGGAAGAUGGGCUGGCdTsdT	antis

1149-1168	3013	UUCCCUGGGGACAGUGGGG	3014	uucccuGGGGAcAGuGGGGdTsdT	sense

1149-1168	3015	CCCCACUGUCCCCAGGGAA	3016	CCCcACUGUCCCcAGGGAAdTsdT	antis

1474-1493	3017	CUGGUGAACUGUCCAUCCA	3018	cuGGuGAAcuGuccAuccAdTsdT	sense

1474-1493	3019	UGGAUGGACAGUUCACCAG	3020	UGGAUGGAcAGUUcACcAGdTsdT	antis

1480-1499	3021	AACUGUCCAUCCAACCAUC	3022	AAcuGuccAuccAAccAucdTsdT	sense

1480-1499	3023	GAUGGUUGGAUGGACAGUU	3024	GAUGGUUGGAUGGAcAGUUdTsdT	antis

1555-1574	3025	CCCUCACCACUUCCUACAA	3026	cccucAccAcuuccuAcAAdTsdT	sense

1555-1574	3027	UUGUAGGAAGUGGUGAGGG	3028	UUGuAGGAAGUGGUGAGGGdTsdT	antis

1848-1867	3029	AGGAUUUUAACUGUUUGUA	3030	AGGAuuuuAAcuGuuuGuAdTsdT	sense

1848-1867	3031	UACAAACAGUUAAAAUCCU	3032	uAcAAAcAGUuAAAAUCCUdTsdT	antis

2031-2050	3033	CCUGGGUGUAAAUAGAUUG	3034	ccuGGGuGuAAAuAGAuuGdTsdT	sense

2031-2050	3035	CAAUCUAUUUACACCCAGG	3036	cAAUCuAUUuAcACCcAGGdTsdT	antis

2042-2061	3037	AUAGAUUGUUAUAAUUUUU	3038	AuAGAuuGuuAuAAuuuuudTsdT	sense

2042-2061	3039	AAAAAUUAUAACAAUCUAU	3040	AAAAAUuAuAAcAAUCuAUdTsdT	antis

2127-2146	3041	UGCUCCCAAGGCUUCCUCC	3042	uGcucccAAGGcuuccuccdTsdT	sense

2127-2146	3043	GGAGGAAGCCUUGGGAGCA	3044	GGAGGAAGCCUUGGGAGcAdTsdT	antis

2230-2249	3045	UGUUCAAUAAAUUAUUGGC	3046	uGuucAAuAAAuuAuuGGcdTsdT	sense

2230-2249	3047	GCCAAUAAUUUAUUGAACA	3048	GCcAAuAAUUuAUUGAAcAdTsdT	antis

48-67	3049	CCCCGCGGCGGGCGCUGGG	3050	ccccGcGGcGGGcGcuGGGdTsdT	sense

48-67	3051	CCCAGCGCCCGCCGCGGGG	3052	CCcAGCGCCCGCCGCGGGGdTsdT	antis

50-69	3053	CCGCGGCGGGCGCUGGGCC	3054	ccGcGGcGGGcGcuGGGccdTsdT	sense

50-69	3055	GGCCCAGCGCCCGCCGCGG	3056	GGCCcAGCGCCCGCCGCGGdTsdT	antis

56-75	3057	CGGGCGCUGGGCCGGAGCC	3058	cGGGcGcuGGGccGGAGccdTsdT	sense

56-75	3059	GGCUCCGGCCCAGCGCCCG	3060	GGCUCCGGCCcAGCGCCCGdTsdT	antis

89-108	3061	GCGGCCUGGAAGAGGCCGG	3062	GcGGccuGGAAGAGGccGGdTsdT	sense

89-108	3063	CCGGCCUCUUCCAGGCCGC	3064	CCGGCCUCUUCcAGGCCGCdTsdT	antis

91-110	3065	GGCCUGGAAGAGGCCGGAG	3066	GGccuGGAAGAGGccGGAGdTsdT	sense

91-110	3067	CUCCGGCCUCUUCCAGGCC	3068	CUCCGGCCUCUUCcAGGCCdTsdT	antis

95-114	3069	UGGAAGAGGCCGGAGCCCA	3070	uGGAAGAGGccGGAGcccAdTsdT	sense

95-114	3071	UGGGCUCCGGCCUCUUCCA	3072	UGGGCUCCGGCCUCUUCcAdTsdT	antis

96-115	3073	GGAAGAGGCCGGAGCCCAG	3074	GGAAGAGGccGGAGcccAGdTsdT	sense

96-115	3075	CUGGGCUCCGGCCUCUUCC	3076	CUGGGCUCCGGCCUCUUCCdTsdT	antis

103-122	3077	GCCGGAGCCCAGGGGAGGC	3078	GccGGAGcccAGGGGAGGcdTsdT	sense

103-122	3079	GCCUCCCCUGGGCUCCGGC	3080	GCCUCCCCUGGGCUCCGGCdTsdT	antis

104-123	3081	CCGGAGCCCAGGGGAGGCG	3082	ccGGAGcccAGGGGAGGcGdTsdT	sense

104-123	3083	CGCCUCCCCUGGGCUCCGG	3084	CGCCUCCCCUGGGCUCCGGdTsdT	antis

105-124	3085	CGGAGCCCAGGGGAGGCGG	3086	cGGAGcccAGGGGAGGcGGdTsdT	sense

105-124	3087	CCGCCUCCCCUGGGCUCCG	3088	CCGCCUCCCCUGGGCUCCGdTsdT	antis

134-153	3089	AGCGGCGGGGGCAGCCCAG	3090	AGcGGcGGGGGcAGcccAGdTsdT	sense

134-153	3091	CUGGGCUGCCCCCGCCGCU	3092	CUGGGCUGCCCCCGCCGCUdTsdT	antis

147-166	3093	GCCCAGGCAGCCCGAGCCC	3094	GcccAGGcAGcccGAGcccdTsdT	sense

147-166	3095	GGGCUCGGGCUGCCUGGGC	3096	GGGCUCGGGCUGCCUGGGCdTsdT	antis

158-177	3097	CCGAGCCCCGCGGCCUGGG	3098	ccGAGccccGcGGccuGGGdTsdT	sense

158-177	3099	CCCAGGCCGCGGGGCUCGG	3100	CCcAGGCCGCGGGGCUCGGdTsdT	antis

167-186	3101	GCGGCCUGGGCCUGCGCUC	3102	GcGGccuGGGccuGcGcucdTsdT	sense

167-186	3103	GAGCGCAGGCCCAGGCCGC	3104	GAGCGcAGGCCcAGGCCGCdTsdT	antis

172-191	3105	CUGGGCCUGCGCUCGGCGC	3106	cuGGGccuGcGcucGGcGcdTsdT	sense

172-191	3107	GCGCCGAGCGCAGGCCCAG	3108	GCGCCGAGCGcAGGCCcAGdTsdT	antis

204-223	3109	GGGCCUUCGGGAGGCGGCC	3110	GGGccuucGGGAGGcGGccdTsdT	sense

204-223	3111	GGCCGCCUCCCGAAGGCCC	3112	GGCCGCCUCCCGAAGGCCCdTsdT	antis

209-228	3113	UUCGGGAGGCGGCCCUGGG	3114	uucGGGAGGcGGcccuGGGdTsdT	sense

209-228	3115	CCCAGGGCCGCCUCCCGAA	3116	CCcAGGGCCGCCUCCCGAAdTsdT	antis

231-250	3117	UCGGGCCGGGCGCGGACCA	3118	ucGGGccGGGcGcGGAccAdTsdT	sense

231-250	3119	UGGUCCGCGCCCGGCCCGA	3120	UGGUCCGCGCCCGGCCCGAdTsdT	antis

256-275	3121	UCGCGGAGCCAGGAGGCGG	3122	ucGcGGAGccAGGAGGcGGdTsdT	sense

256-275	3123	CCGCCUCCUGGCUCCGCGA	3124	CCGCCUCCUGGCUCCGCGAdTsdT	antis

294-313	3125	GGCCCCGGGGGCUCGGCCU	3126	GGccccGGGGGcucGGccudTsdT	sense

294-313	3127	AGGCCGAGCCCCCGGGGCC	3128	AGGCCGAGCCCCCGGGGCCdTsdT	antis

295-314	3129	GCCCCGGGGGCUCGGCCUC	3130	GccccGGGGGcucGGccucdTsdT	sense

295-314	3131	GAGGCCGAGCCCCCGGGGC	3132	GAGGCCGAGCCCCCGGGGCdTsdT	antis

318-337	3133	CCAGGAGGCACUGGCGGCG	3134	ccAGGAGGcAcuGGcGGcGdTsdT	sense

318-337	3135	CGCCGCCAGUGCCUCCUGG	3136	CGCCGCcAGUGCCUCCUGGdTsdT	antis

369-388	3137	GUGGGAGCCUCGAGCUCCG	3138	GuGGGAGccucGAGcuccGdTsdT	sense

369-388	3139	CGGAGCUCGAGGCUCCCAC	3140	CGGAGCUCGAGGCUCCcACdTsdT	antis

386-405	3141	CGGGGGUGGCCCCAGCGGC	3142	cGGGGGuGGccccAGcGGcdTsdT	sense

386-405	3143	GCCGCUGGGGCCACCCCCG	3144	GCCGCUGGGGCcACCCCCGdTsdT	antis

390-409	3145	GGUGGCCCCAGCGGCAGCG	3146	GGuGGccccAGcGGcAGcGdTsdT	sense

390-409	3147	CGCUGCCGCUGGGGCCACC	3148	CGCUGCCGCUGGGGCcACCdTsdT	antis

391-410	3149	GUGGCCCCAGCGGCAGCGG	3150	GuGGccccAGcGGcAGcGGdTsdT	sense

391-410	3151	CCGCUGCCGCUGGGGCCAC	3152	CCGCUGCCGCUGGGGCcACdTsdT	antis

460-479	3153	GAGUGAAGCUGGGCCGUGA	3154	GAGuGAAGcuGGGccGuGAdTsdT	sense

460-479	3155	UCACGGCCCAGCUUCACUC	3156	UcACGGCCcAGCUUcACUCdTsdT	antis

491-510	3157	GACCACAGUGGUAGCCACU	3158	GAccAcAGuGGuAGccAcudTsdT	sense

491-510	3159	AGUGGCUACCACUGUGGUC	3160	AGUGGCuACcACUGUGGUCdTsdT	antis

494-513	3161	CACAGUGGUAGCCACUGUA	3162	cAcAGuGGuAGccAcuGuAdTsdT	sense

494-513	3163	UACAGUGGCUACCACUGUG	3164	uAcAGUGGCuACcACUGUGdTsdT	antis

504-523	3165	GCCACUGUAGGCCAAGGCC	3166	GccAcuGuAGGccAAGGccdTsdT	sense

504-523	3167	GGCCUUGGCCUACAGUGGC	3168	GGCCUUGGCCuAcAGUGGCdTsdT	antis

593-612	3169	CCAGGCACGGCUGGCAGAG	3170	ccAGGcAcGGcuGGcAGAGdTsdT	sense

593-612	3171	CUCUGCCAGCCGUGCCUGG	3172	CUCUGCcAGCCGUGCCUGGdTsdT	antis

600-619	3173	CGGCUGGCAGAGACGAGGG	3174	cGGcuGGcAGAGAcGAGGGdTsdT	sense

600-619	3175	CCCUCGUCUCUGCCAGCCG	3176	CCCUCGUCUCUGCcAGCCGdTsdT	antis

613-632	3177	CGAGGGAACUGGUGGCCAU	3178	cGAGGGAAcuGGuGGccAudTsdT	sense

613-632	3179	AUGGCCACCAGUUCCCUCG	3180	AUGGCcACcAGUUCCCUCGdTsdT	antis

650-669	3181	CAAAAGGUUCAAGAACCGA	3182	cAAAAGGuucAAGAAccGAdTsdT	sense

650-669	3183	UCGGUUCUUGAACCUUUUG	3184	UCGGUUCUUGAACCUUUUGdTsdT	antis

841-860	3185	CUAUCAUCUACAUCAAGGU	3186	cuAucAucuAcAucAAGGudTsdT	sense

841-860	3187	ACCUUGAUGUAGAUGAUAG	3188	ACCUUGAUGuAGAUGAuAGdTsdT	antis

842-861	3189	UAUCAUCUACAUCAAGGUG	3190	uAucAucuAcAucAAGGuGdTsdT	sense

842-861	3191	CACCUUGAUGUAGAUGAUA	3192	cACCUUGAUGuAGAUGAuAdTsdT	antis

895-914	3193	UCCACUCCCAAGGUGUGUG	3194	uccAcucccAAGGuGuGuGdTsdT	sense

895-914	3195	CACACACCUUGGGAGUGGA	3196	cAcAcACCUUGGGAGUGGAdTsdT	antis

900-919	3197	UCCCAAGGUGUGUGUCACC	3198	ucccAAGGuGuGuGucAccdTsdT	sense

900-919	3199	GGUGACACACACCUUGGGA	3200	GGUGAcAcAcACCUUGGGAdTsdT	antis

901-920	3201	CCCAAGGUGUGUGUCACCG	3202	cccAAGGuGuGuGucAccGdTsdT	sense

901-920	3203	CGGUGACACACACCUUGGG	3204	CGGUGAcAcAcACCUUGGGdTsdT	antis

924-943	3205	AUCAAGCCCCAGAAUUUGC	3206	AucAAGccccAGAAuuuGcdTsdT	sense

924-943	3207	GCAAAUUCUGGGGCUUGAU	3208	GcAAAUUCUGGGGCUUGAUdTsdT	antis

925-944	3209	UCAAGCCCCAGAAUUUGCU	3210	ucAAGccccAGAAuuuGcudTsdT	sense

925-944	3211	AGCAAAUUCUGGGGCUUGA	3212	AGcAAAUUCUGGGGCUUGAdTsdT	antis

926-945	3213	CAAGCCCCAGAAUUUGCUU	3214	cAAGccccAGAAuuuGcuudTsdT	sense

926-945	3215	AAGCAAAUUCUGGGGCUUG	3216	AAGcAAAUUCUGGGGCUUGdTsdT	antis

953-972	3217	UGACACUGCUGUCCUCAAG	3218	uGAcAcuGcuGuccucAAGdTsdT	sense

953-972	3219	CUUGAGGACAGCAGUGUCA	3220	CUUGAGGAcAGcAGUGUcAdTsdT	antis

1053-1072	3221	CCAGAACUCAUCUUUGGAG	3222	ccAGAAcucAucuuuGGAGdTsdT	sense

1053-1072	3223	CUCCAAAGAUGAGUUCUGG	3224	CUCcAAAGAUGAGUUCUGGdTsdT	antis

1057-1076	3225	AACUCAUCUUUGGAGCCAC	3226	AAcucAucuuuGGAGccAcdTsdT	sense

1057-1076	3227	GUGGCUCCAAAGAUGAGUU	3228	GUGGCUCcAAAGAUGAGUUdTsdT	antis

1063-1082	3229	UCUUUGGAGCCACAGAUUA	3230	ucuuuGGAGccAcAGAuuAdTsdT	sense

1063-1082	3231	UAAUCUGUGGCUCCAAAGA	3232	uAAUCUGUGGCUCcAAAGAdTsdT	antis

1069-1088	3233	GAGCCACAGAUUACACCUC	3234	GAGccAcAGAuuAcAccucdTsdT	sense

1069-1088	3235	GAGGUGUAAUCUGUGGCUC	3236	GAGGUGuAAUCUGUGGCUCdTsdT	antis

1106-1125	3237	GGCUGGCUGUGUACUUGCU	3238	GGcuGGcuGuGuAcuuGcudTsdT	sense

1106-1125	3239	AGCAAGUACACAGCCAGCC	3240	AGcAAGuAcAcAGCcAGCCdTsdT	antis

1118-1137	3241	ACUUGCUGAGCUACUUCUC	3242	AcuuGcuGAGcuAcuucucdTsdT	sense

1118-1137	3243	GAGAAGUAGCUCAGCAAGU	3244	GAGAAGuAGCUcAGcAAGUdTsdT	antis

1135-1154	3245	UCGGCCAGCCCAUCUUCCC	3246	ucGGccAGcccAucuucccdTsdT	sense

1135-1154	3247	GGGAAGAUGGGCUGGCCGA	3248	GGGAAGAUGGGCUGGCCGAdTsdT	antis

1137-1156	3249	GGCCAGCCCAUCUUCCCUG	3250	GGccAGcccAucuucccuGdTsdT	sense

1137-1156	3251	CAGGGAAGAUGGGCUGGCC	3252	cAGGGAAGAUGGGCUGGCCdTsdT	antis

1140-1159	3253	CAGCCCAUCUUCCCUGGGG	3254	cAGcccAucuucccuGGGGdTsdT	sense

1140-1159	3255	CCCCAGGGAAGAUGGGCUG	3256	CCCcAGGGAAGAUGGGCUGdTsdT	antis

1145-1164	3257	CAUCUUCCCUGGGGACAGU	3258	cAucuucccuGGGGAcAGudTsdT	sense

1145-1164	3259	ACUGUCCCCAGGGAAGAUG	3260	ACUGUCCCcAGGGAAGAUGdTsdT	antis

1150-1169	3261	UCCCUGGGGACAGUGGGGU	3262	ucccuGGGGAcAGuGGGGudTsdT	sense

1150-1169	3263	ACCCCACUGUCCCCAGGGA	3264	ACCCcACUGUCCCcAGGGAdTsdT	antis

1270-1289	3265	AAGCUCACCCUUGGACAAA	3266	AAGcucAcccuuGGAcAAAdTsdT	sense

1270-1289	3267	UUUGUCCAAGGGUGAGCUU	3268	UUUGUCcAAGGGUGAGCUUdTsdT	antis

1296-1315	3269	AAAUCUUCAAAGACACCAC	3270	AAAucuucAAAGAcAccAcdTsdT	sense

1296-1315	3271	GUGGUGUCUUUGAAGAUUU	3272	GUGGUGUCUUUGAAGAUUUdTsdT	antis

1297-1316	3273	AAUCUUCAAAGACACCACC	3274	AAucuucAAAGAcAccAccdTsdT	sense

1297-1316	3275	GGUGGUGUCUUUGAAGAUU	3276	GGUGGUGUCUUUGAAGAUUdTsdT	antis

1302-1321	3277	UCAAAGACACCACCUGAGG	3278	ucAAAGAcAccAccuGAGGdTsdT	sense

1302-1321	3279	CCUCAGGUGGUGUCUUUGA	3280	CCUcAGGUGGUGUCUUUGAdTsdT	antis

1309-1328	3281	CACCACCUGAGGCCAUUGC	3282	cAccAccuGAGGccAuuGcdTsdT	sense

1309-1328	3283	GCAAUGGCCUCAGGUGGUG	3284	GcAAUGGCCUcAGGUGGUGdTsdT	antis

1331-1350	3285	CUGCUCUAGCCUACUGGAG	3286	cuGcucuAGccuAcuGGAGdTsdT	sense

1331-1350	3287	CUCCAGUAGGCUAGAGCAG	3288	CUCcAGuAGGCuAGAGcAGdTsdT	antis

1422-1441	3289	GGAGCCCAGCUCCCCAACG	3290	GGAGcccAGcuccccAAcGdTsdT	sense

1422-1441	3291	CGUUGGGGAGCUGGGCUCC	3292	CGUUGGGGAGCUGGGCUCCdTsdT	antis

1441-1460	3293	ACCGCCCGCUUCCCCCCCU	3294	AccGcccGcuucccccccudTsdT	sense

1441-1460	3295	AGGGGGGGAAGCGGGCGGU	3296	AGGGGGGGAAGCGGGCGGUdTsdT	antis

1475-1494	3297	UGGUGAACUGUCCAUCCAA	3298	uGGuGAAcuGuccAuccAAdTsdT	sense

1475-1494	3299	UUGGAUGGACAGUUCACCA	3300	UUGGAUGGAcAGUUcACcAdTsdT	antis

1490-1509	3301	CCAACCAUCUCUCAAUGCC	3302	ccAAccAucucucAAuGccdTsdT	sense

1490-1509	3303	GGCAUUGAGAGAUGGUUGG	3304	GGcAUUGAGAGAUGGUUGGdTsdT	antis

1543-1562	3305	GCCCUGCUUCUCCCCUCAC	3306	GcccuGcuucuccccucAcdTsdT	sense

1543-1562	3307	GUGAGGGGAGAAGCAGGGC	3308	GUGAGGGGAGAAGcAGGGCdTsdT	antis

1544-1563	3309	CCCUGCUUCUCCCCUCACC	3310	cccuGcuucuccccucAccdTsdT	sense

1544-1563	3311	GGUGAGGGGAGAAGCAGGG	3312	GGUGAGGGGAGAAGcAGGGdTsdT	antis

1545-1564	3313	CCUGCUUCUCCCCUCACCA	3314	ccuGcuucuccccucAccAdTsdT	sense

1545-1564	3315	UGGUGAGGGGAGAAGCAGG	3316	UGGUGAGGGGAGAAGcAGGdTsdT	antis

1546-1565	3317	CUGCUUCUCCCCUCACCAC	3318	cuGcuucuccccucAccAcdTsdT	sense

1546-1565	3319	GUGGUGAGGGGAGAAGCAG	3320	GUGGUGAGGGGAGAAGcAGdTsdT	antis

1550-1569	3321	UUCUCCCCUCACCACUUCC	3322	uucuccccucAccAcuuccdTsdT	sense

1550-1569	3323	GGAAGUGGUGAGGGGAGAA	3324	GGAAGUGGUGAGGGGAGAAdTsdT	antis

1559-1578	3325	CACCACUUCCUACAACCCA	3326	cAccAcuuccuAcAAcccAdTsdT	sense

1559-1578	3327	UGGGUUGUAGGAAGUGGUG	3328	UGGGUUGuAGGAAGUGGUGdTsdT	antis

1574-1593	3329	CCCAUCCUCACAAGCUUUA	3330	cccAuccucAcAAGcuuuAdTsdT	sense

1574-1593	3331	UAAAGCUUGUGAGGAUGGG	3332	uAAAGCUUGUGAGGAUGGGdTsdT	antis

1585-1604	3333	AAGCUUUAACUGAAGCUCA	3334	AAGcuuuAAcuGAAGcucAdTsdT	sense

1585-1604	3335	UGAGCUUCAGUUAAAGCUU	3336	UGAGCUUcAGUuAAAGCUUdTsdT	antis

1598-1617	3337	AGCUCAGACUGGCCAAGAU	3338	AGcucAGAcuGGccAAGAudTsdT	sense

1598-1617	3339	AUCUUGGCCAGUCUGAGCU	3340	AUCUUGGCcAGUCUGAGCUdTsdT	antis

1599-1618	3341	GCUCAGACUGGCCAAGAUU	3342	GcucAGAcuGGccAAGAuudTsdT	sense

1599-1618	3343	AAUCUUGGCCAGUCUGAGC	3344	AAUCUUGGCcAGUCUGAGCdTsdT	antis

1605-1624	3345	ACUGGCCAAGAUUGGCAGC	3346	AcuGGccAAGAuuGGcAGcdTsdT	sense

1605-1624	3347	GCUGCCAAUCUUGGCCAGU	3348	GCUGCcAAUCUUGGCcAGUdTsdT	antis

1611-1630	3349	CAAGAUUGGCAGCCAUCUG	3350	cAAGAuuGGcAGccAucuGdTsdT	sense

1611-1630	3351	CAGAUGGCUGCCAAUCUUG	3352	cAGAUGGCUGCcAAUCUUGdTsdT	antis

1612-1631	3353	AAGAUUGGCAGCCAUCUGA	3354	AAGAuuGGcAGccAucuGAdTsdT	sense

1612-1631	3355	UCAGAUGGCUGCCAAUCUU	3356	UcAGAUGGCUGCcAAUCUUdTsdT	antis

1651-1670	3357	CUAGCUCUUCCUGAGGGCC	3358	cuAGcucuuccuGAGGGccdTsdT	sense

1651-1670	3359	GGCCCUCAGGAAGAGCUAG	3360	GGCCCUcAGGAAGAGCuAGdTsdT	antis

1655-1674	3361	CUCUUCCUGAGGGCCCCAC	3362	cucuuccuGAGGGccccAcdTsdT	sense

1655-1674	3363	GUGGGGCCCUCAGGAAGAG	3364	GUGGGGCCCUcAGGAAGAGdTsdT	antis

1656-1675	3365	UCUUCCUGAGGGCCCCACC	3366	ucuuccuGAGGGccccAccdTsdT	sense

1656-1675	3367	GGUGGGGCCCUCAGGAAGA	3368	GGUGGGGCCCUcAGGAAGAdTsdT	antis

1803-1822	3369	UAGGCCUCCCUCAGCAGCC	3370	uAGGccucccucAGcAGccdTsdT	sense

1803-1822	3371	GGCUGCUGAGGGAGGCCUA	3372	GGCUGCUGAGGGAGGCCuAdTsdT	antis

1804-1823	3373	AGGCCUCCCUCAGCAGCCU	3374	AGGccucccucAGcAGccudTsdT	sense

1804-1823	3375	AGGCUGCUGAGGGAGGCCU	3376	AGGCUGCUGAGGGAGGCCUdTsdT	antis

1805-1824	3377	GGCCUCCCUCAGCAGCCUA	3378	GGccucccucAGcAGccuAdTsdT	sense

1805-1824	3379	UAGGCUGCUGAGGGAGGCC	3380	uAGGCUGCUGAGGGAGGCCdTsdT	antis

1806-1825	3381	GCCUCCCUCAGCAGCCUAA	3382	GccucccucAGcAGccuAAdTsdT	sense

1806-1825	3383	UUAGGCUGCUGAGGGAGGC	3384	UuAGGCUGCUGAGGGAGGCdTsdT	antis

1810-1829	3385	CCCUCAGCAGCCUAACCUC	3386	cccucAGcAGccuAAccucdTsdT	sense

1810-1829	3387	GAGGUUAGGCUGCUGAGGG	3388	GAGGUuAGGCUGCUGAGGGdTsdT	antis

1846-1865	3389	AGAGGAUUUUAACUGUUUG	3390	AGAGGAuuuuAAcuGuuuGdTsdT	sense

1846-1865	3391	CAAACAGUUAAAAUCCUCU	3392	cAAAcAGUuAAAAUCCUCUdTsdT	antis

1871-1890	3393	AGGGGAGAAAAGGAAGGAC	3394	AGGGGAGAAAAGGAAGGAcdTsdT	sense

1871-1890	3395	GUCCUUCCUUUUCUCCCCU	3396	GUCCUUCCUUUUCUCCCCUdTsdT	antis

1873-1892	3397	GGGAGAAAAGGAAGGACGG	3398	GGGAGAAAAGGAAGGAcGGdTsdT	sense

1873-1892	3399	CCGUCCUUCCUUUUCUCCC	3400	CCGUCCUUCCUUUUCUCCCdTsdT	antis

1877-1896	3401	GAAAAGGAAGGACGGGGUU	3402	GAAAAGGAAGGAcGGGGuudTsdT	sense

1877-1896	3403	AACCCCGUCCUUCCUUUUC	3404	AACCCCGUCCUUCCUUUUCdTsdT	antis

1933-1952	3405	CCCUCCCCCAGGCUACCAC	3406	cccucccccAGGcuAccAcdTsdT	sense

1933-1952	3407	GUGGUAGCCUGGGGGAGGG	3408	GUGGuAGCCUGGGGGAGGGdTsdT	antis

1934-1953	3409	CCUCCCCCAGGCUACCACU	3410	ccucccccAGGcuAccAcudTsdT	sense

1934-1953	3411	AGUGGUAGCCUGGGGGAGG	3412	AGUGGuAGCCUGGGGGAGGdTsdT	antis

1940-1959	3413	CCAGGCUACCACUCCUUCC	3414	ccAGGcuAccAcuccuuccdTsdT	sense

1940-1959	3415	GGAAGGAGUGGUAGCCUGG	3416	GGAAGGAGUGGuAGCCUGGdTsdT	antis

1941-1960	3417	CAGGCUACCACUCCUUCCC	3418	cAGGcuAccAcuccuucccdTsdT	sense

1941-1960	3419	GGGAAGGAGUGGUAGCCUG	3420	GGGAAGGAGUGGuAGCCUGdTsdT	antis

1945-1964	3421	CUACCACUCCUUCCCUCCC	3422	cuAccAcuccuucccucccdTsdT	sense

1945-1964	3423	GGGAGGGAAGGAGUGGUAG	3424	GGGAGGGAAGGAGUGGuAGdTsdT	antis

1946-1965	3425	UACCACUCCUUCCCUCCCC	3426	uAccAcuccuucccuccccdTsdT	sense

1946-1965	3427	GGGGAGGGAAGGAGUGGUA	3428	GGGGAGGGAAGGAGUGGuAdTsdT	antis

1953-1972	3429	CCUUCCCUCCCCCCCUCUC	3430	ccuucccucccccccucucdTsdT	sense

1953-1972	3431	GAGAGGGGGGGAGGGAAGG	3432	GAGAGGGGGGGAGGGAAGGdTsdT	antis

2023-2042	3433	CCUGGCCCCCUGGGUGUAA	3434	ccuGGcccccuGGGuGuAAdTsdT	sense

2023-2042	3435	UUACACCCAGGGGGCCAGG	3436	UuAcACCcAGGGGGCcAGGdTsdT	antis

2024-2043	3437	CUGGCCCCCUGGGUGUAAA	3438	cuGGcccccuGGGuGuAAAdTsdT	sense

2024-2043	3439	UUUACACCCAGGGGGCCAG	3440	UUuAcACCcAGGGGGCcAGdTsdT	antis

2040-2059	3441	AAAUAGAUUGUUAUAAUUU	3442	AAAuAGAuuGuuAuAAuuudTsdT	sense

2040-2059	3443	AAAUUAUAACAAUCUAUUU	3444	AAAUuAuAAcAAUCuAUUUdTsdT	antis

2043-2062	3445	UAGAUUGUUAUAAUUUUUU	3446	uAGAuuGuuAuAAuuuuuudTsdT	sense

2043-2062	3447	AAAAAAUUAUAACAAUCUA	3448	AAAAAAUuAuAAcAAUCuAdTsdT	antis

2044-2063	3449	AGAUUGUUAUAAUUUUUUC	3450	AGAuuGuuAuAAuuuuuucdTsdT	sense

2044-2063	3451	GAAAAAAUUAUAACAAUCU	3452	GAAAAAAUuAuAAcAAUCUdTsdT	antis

2045-2064	3453	GAUUGUUAUAAUUUUUUCU	3454	GAuuGuuAuAAuuuuuucudTsdT	sense

2045-2064	3455	AGAAAAAAUUAUAACAAUC	3456	AGAAAAAAUuAuAAcAAUCdTsdT	antis

2046-2065	3457	AUUGUUAUAAUUUUUUCUU	3458	AuuGuuAuAAuuuuuucuudTsdT	sense

2046-2065	3459	AAGAAAAAAUUAUAACAAU	3460	AAGAAAAAAUuAuAAcAAUdTsdT	antis

2049-2068	3461	GUUAUAAUUUUUUCUUAAA	3462	GuuAuAAuuuuuucuuAAAdTsdT	sense

2049-2068	3463	UUUAAGAAAAAAUUAUAAC	3464	UUuAAGAAAAAAUuAuAACdTsdT	antis

2117-2136	3465	UCUUGUCCUCUGCUCCCAA	3466	ucuuGuccucuGcucccAAdTsdT	sense

2117-2136	3467	UUGGGAGCAGAGGACAAGA	3468	UUGGGAGcAGAGGAcAAGAdTsdT	antis

2118-2137	3469	CUUGUCCUCUGCUCCCAAG	3470	cuuGuccucuGcucccAAGdTsdT	sense

2118-2137	3471	CUUGGGAGCAGAGGACAAG	3472	CUUGGGAGcAGAGGAcAAGdTsdT	antis

2129-2148	3473	CUCCCAAGGCUUCCUCCCU	3474	cucccAAGGcuuccucccudTsdT	sense

2129-2148	3475	AGGGAGGAAGCCUUGGGAG	3476	AGGGAGGAAGCCUUGGGAGdTsdT	antis

2130-2149	3477	UCCCAAGGCUUCCUCCCUC	3478	ucccAAGGcuuccucccucdTsdT	sense

2130-2149	3479	GAGGGAGGAAGCCUUGGGA	3480	GAGGGAGGAAGCCUUGGGAdTsdT	antis

2133-2152	3481	CAAGGCUUCCUCCCUCUCC	3482	cAAGGcuuccucccucuccdTsdT	sense

2133-2152	3483	GGAGAGGGAGGAAGCCUUG	3484	GGAGAGGGAGGAAGCCUUGdTsdT	antis

2134-2153	3485	AAGGCUUCCUCCCUCUCCC	3486	AAGGcuuccucccucucccdTsdT	sense

2134-2153	3487	GGGAGAGGGAGGAAGCCUU	3488	GGGAGAGGGAGGAAGCCUUdTsdT	antis

2146-2165	3489	CUCUCCCCAUCCUGGAAGG	3490	cucuccccAuccuGGAAGGdTsdT	sense

2146-2165	3491	CCUUCCAGGAUGGGGAGAG	3492	CCUUCcAGGAUGGGGAGAGdTsdT	antis

2150-2169	3493	CCCCAUCCUGGAAGGAGGG	3494	ccccAuccuGGAAGGAGGGdTsdT	sense

2150-2169	3495	CCCUCCUUCCAGGAUGGGG	3496	CCCUCCUUCcAGGAUGGGGdTsdT	antis

2152-2171	3497	CCAUCCUGGAAGGAGGGGA	3498	ccAuccuGGAAGGAGGGGAdTsdT	sense

2152-2171	3499	UCCCCUCCUUCCAGGAUGG	3500	UCCCCUCCUUCcAGGAUGGdTsdT	antis

2156-2175	3501	CCUGGAAGGAGGGGAGUAG	3502	ccuGGAAGGAGGGGAGuAGdTsdT	sense

2156-2175	3503	CUACUCCCCUCCUUCCAGG	3504	CuACUCCCCUCCUUCcAGGdTsdT	antis

2161-2180	3505	AAGGAGGGGAGUAGAGAGA	3506	AAGGAGGGGAGuAGAGAGAdTsdT	sense

2161-2180	3507	UCUCUCUACUCCCCUCCUU	3508	UCUCUCuACUCCCCUCCUUdTsdT	antis

2208-2227	3509	GGUUUGCCUGUGUACAGAC	3510	GGuuuGccuGuGuAcAGAcdTsdT	sense

2208-2227	3511	GUCUGUACACAGGCAAACC	3512	GUCUGuAcAcAGGcAAACCdTsdT	antis

2219-2238	3513	GUACAGACCUCUGUUCAAU	3514	GuAcAGAccucuGuucAAudTsdT	sense

2219-2238	3515	AUUGAACAGAGGUCUGUAC	3516	AUUGAAcAGAGGUCUGuACdTsdT	antis

2233-2252	3517	UCAAUAAAUUAUUGGCAUG	3518	ucAAuAAAuuAuuGGcAuGdTsdT	sense

2233-2252	3519	CAUGCCAAUAAUUUAUUGA	3520	cAUGCcAAuAAUUuAUUGAdTsdT	antis

2-21	3521	UGGUGACAACGAAGCCGAC	3522	uGGuGAcAAcGAAGccGAcdTsdT	sense

2-21	3523	GUCGGCUUCGUUGUCACCA	3524	GUCGGCUUCGUUGUcACcAdTsdT	antis

138-157	3525	GCGGGGGCAGCCCAGGCAG	3526	GcGGGGGcAGcccAGGcAGdTsdT	sense

138-157	3527	CUGCCUGGGCUGCCCCCGC	3528	CUGCCUGGGCUGCCCCCGCdTsdT	antis

381-400	3529	AGCUCCGGGGGUGGCCCCA	3530	AGcuccGGGGGuGGccccAdTsdT	sense

381-400	3531	UGGGGCCACCCCCGGAGCU	3532	UGGGGCcACCCCCGGAGCUdTsdT	antis

592-611	3533	ACCAGGCACGGCUGGCAGA	3534	AccAGGcAcGGcuGGcAGAdTsdT	sense

592-611	3535	UCUGCCAGCCGUGCCUGGU	3536	UCUGCcAGCCGUGCCUGGUdTsdT	antis

615-634	3537	AGGGAACUGGUGGCCAUCA	3538	AGGGAAcuGGuGGccAucAdTsdT	sense

615-634	3539	UGAUGGCCACCAGUUCCCU	3540	UGAUGGCcACcAGUUCCCUdTsdT	antis

1026-1045	3541	UACAUCUGCUCUCGGUACU	3542	uAcAucuGcucucGGuAcudTsdT	sense

1026-1045	3543	AGUACCGAGAGCAGAUGUA	3544	AGuACCGAGAGcAGAUGuAdTsdT	antis

1027-1046	3545	ACAUCUGCUCUCGGUACUA	3546	AcAucuGcucucGGuAcuAdTsdT	sense

1027-1046	3547	UAGUACCGAGAGCAGAUGU	3548	uAGuACCGAGAGcAGAUGUdTsdT	antis

1105-1124	3549	CGGCUGGCUGUGUACUUGC	3550	cGGcuGGcuGuGuAcuuGcdTsdT	sense

1105-1124	3551	GCAAGUACACAGCCAGCCG	3552	GcAAGuAcAcAGCcAGCCGdTsdT	antis

1362-1381	3553	UCAAGGCUCUCCCCACUCG	3554	ucAAGGcucuccccAcucGdTsdT	sense

1362-1381	3555	CGAGUGGGGAGAGCCUUGA	3556	CGAGUGGGGAGAGCCUUGAdTsdT	antis

1440-1459	3557	GACCGCCCGCUUCCCCCCC	3558	GAccGcccGcuucccccccdTsdT	sense

1440-1459	3559	GGGGGGGAAGCGGGCGGUC	3560	GGGGGGGAAGCGGGCGGUCdTsdT	antis

2017-2036	3561	CCCUUCCCUGGCCCCCUGG	3562	cccuucccuGGcccccuGGdTsdT	sense

2017-2036	3563	CCAGGGGGCCAGGGAAGGG	3564	CcAGGGGGCcAGGGAAGGGdTsdT	antis

2018-2037	3565	CCUUCCCUGGCCCCCUGGG	3566	ccuucccuGGcccccuGGGdTsdT	sense

2018-2037	3567	CCCAGGGGGCCAGGGAAGG	3568	CCcAGGGGGCcAGGGAAGGdTsdT	antis

2019-2038	3569	CUUCCCUGGCCCCCUGGGU	3570	cuucccuGGcccccuGGGudTsdT	sense

2019-2038	3571	ACCCAGGGGGCCAGGGAAG	3572	ACCcAGGGGGCcAGGGAAGdTsdT	antis

2148-2167	3573	CUCCCCAUCCUGGAAGGAG	3574	cuccccAuccuGGAAGGAGdTsdT	sense

2148-2167	3575	CUCCUUCCAGGAUGGGGAG	3576	CUCCUUCcAGGAUGGGGAGdTsdT	antis

2149-2168	3577	UCCCCAUCCUGGAAGGAGG	3578	uccccAuccuGGAAGGAGGdTsdT	sense

2149-2168	3579	CCUCCUUCCAGGAUGGGGA	3580	CCUCCUUCcAGGAUGGGGAdTsdT	antis

1335-1354	3581	UCUAGCCUACUGGAGUACA	3582	ucuAGccuAcuGGAGuAcAdTsdT	sense

1335-1354	3583	UGUACUCCAGUAGGCUAGA	3584	UGuACUCcAGuAGGCuAGAdTsdT	antis

342-361	3585	GCGUCAGUCGGGGCUAUGG	3586	GcGucAGucGGGGcuAuGGdTsdT	sense

342-361	3587	CCAUAGCCCCGACUGACGC	3588	CcAuAGCCCCGACUGACGCdTsdT	antis

675-694	3589	CAGAUUAUGCGUAAGCUGG	3590	cAGAuuAuGcGuAAGcuGGdTsdT	sense

675-694	3591	CCAGCUUACGCAUAAUCUG	3592	CcAGCUuACGcAuAAUCUGdTsdT	antis

1080-1099	3593	UACACCUCGUCCAUCGAUG	3594	uAcAccucGuccAucGAuGdTsdT	sense

1080-1099	3595	CAUCGAUGGACGAGGUGUA	3596	cAUCGAUGGACGAGGUGuAdTsdT	antis

333-352	3597	GGCGGGAAAGCGUCAGUCG	3598	GGcGGGAAAGcGucAGucGdTsdT	sense

333-352	3599	CGACUGACGCUUUCCCGCC	3600	CGACUGACGCUUUCCCGCCdTsdT	antis

475-494	3601	GUGACAGCGGGAAGGUGAC	3602	GuGAcAGcGGGAAGGuGAcdTsdT	sense

475-494	3603	GUCACCUUCCCGCUGUCAC	3604	GUcACCUUCCCGCUGUcACdTsdT	antis

533-552	3605	CCAAGAAGUGGCUUACACU	3606	ccAAGAAGuGGcuuAcAcudTsdT	sense

533-552	3607	AGUGUAAGCCACUUCUUGG	3608	AGUGuAAGCcACUUCUUGGdTsdT	antis

746-765	3609	GAAGGACGAGCUGUAUUUG	3610	GAAGGAcGAGcuGuAuuuGdTsdT	sense

746-765	3611	CAAAUACAGCUCGUCCUUC	3612	cAAAuAcAGCUCGUCCUUCdTsdT	antis

747-766	3613	AAGGACGAGCUGUAUUUGA	3614	AAGGAcGAGcuGuAuuuGAdTsdT	sense

747-766	3615	UCAAAUACAGCUCGUCCUU	3616	UcAAAuAcAGCUCGUCCUUdTsdT	antis

830-849	3617	GCUGAUCACCCCUAUCAUC	3618	GcuGAucAccccuAucAucdTsdT	sense

830-849	3619	GAUGAUAGGGGUGAUCAGC	3620	GAUGAuAGGGGUGAUcAGCdTsdT	antis

1334-1353	3621	CUCUAGCCUACUGGAGUAC	3622	cucuAGccuAcuGGAGuAcdTsdT	sense

1334-1353	3623	GUACUCCAGUAGGCUAGAG	3624	GuACUCcAGuAGGCuAGAGdTsdT	antis

497-516	3625	AGUGGUAGCCACUGUAGGC	3626	AGuGGuAGccAcuGuAGGcdTsdT	sense

497-516	3627	GCCUACAGUGGCUACCACU	3628	GCCuAcAGUGGCuACcACUdTsdT	antis

1641-1660	3629	GCUACCCUCGCUAGCUCUU	3630	GcuAcccucGcuAGcucuudTsdT	sense

1641-1660	3631	AAGAGCUAGCGAGGGUAGC	3632	AAGAGCuAGCGAGGGuAGCdTsdT	antis

1642-1661	3633	CUACCCUCGCUAGCUCUUC	3634	cuAcccucGcuAGcucuucdTsdT	sense

1642-1661	3635	GAAGAGCUAGCGAGGGUAG	3636	GAAGAGCuAGCGAGGGuAGdTsdT	antis

676-695	3637	AGAUUAUGCGUAAGCUGGA	3638	AGAuuAuGcGuAAGcuGGAdTsdT	sense

676-695	3639	UCCAGCUUACGCAUAAUCU	3640	UCcAGCUuACGcAuAAUCUdTsdT	antis

1128-1147	3641	CUACUUCUCGGCCAGCCCA	3642	cuAcuucucGGccAGcccAdTsdT	sense

1128-1147	3643	UGGGCUGGCCGAGAAGUAG	3644	UGGGCUGGCCGAGAAGuAGdTsdT	antis

40-59	3645	CCGGCGUGCCCCGCGGCGG	3646	ccGGcGuGccccGcGGcGGdTsdT	sense

40-59	3647	CCGCCGCGGGGCACGCCGG	3648	CCGCCGCGGGGcACGCCGGdTsdT	antis

199-218	3649	GCGGCGGGCCUUCGGGAGG	3650	GcGGcGGGccuucGGGAGGdTsdT	sense

199-218	3651	CCUCCCGAAGGCCCGCCGC	3652	CCUCCCGAAGGCCCGCCGCdTsdT	antis

222-241	3653	CCUGGGGGCUCGGGCCGGG	3654	ccuGGGGGcucGGGccGGGdTsdT	sense

222-241	3655	CCCGGCCCGAGCCCCCAGG	3656	CCCGGCCCGAGCCCCcAGGdTsdT	antis

343-362	3657	CGUCAGUCGGGGCUAUGGG	3658	cGucAGucGGGGcuAuGGGdTsdT	sense

343-362	3659	CCCAUAGCCCCGACUGACG	3660	CCcAuAGCCCCGACUGACGdTsdT	antis

437-456	3661	GGGCACUAGCUUCCCGCCG	3662	GGGcAcuAGcuucccGccGdTsdT	sense

437-456	3663	CGGCGGGAAGCUAGUGCCC	3664	CGGCGGGAAGCuAGUGCCCdTsdT	antis

538-557	3665	AAGUGGCUUACACUGACAU	3666	AAGuGGcuuAcAcuGAcAudTsdT	sense

538-557	3667	AUGUCAGUGUAAGCCACUU	3668	AUGUcAGUGuAAGCcACUUdTsdT	antis

663-682	3669	AACCGAGAACUGCAGAUUA	3670	AAccGAGAAcuGcAGAuuAdTsdT	sense

663-682	3671	UAAUCUGCAGUUCUCGGUU	3672	uAAUCUGcAGUUCUCGGUUdTsdT	antis

887-906	3673	GGCCUACAUCCACUCCCAA	3674	GGccuAcAuccAcucccAAdTsdT	sense

887-906	3675	UUGGGAGUGGAUGUAGGCC	3676	UUGGGAGUGGAUGuAGGCCdTsdT	antis

997-1016	3677	AGCUGGUUCGGGGGGAGCC	3678	AGcuGGuucGGGGGGAGccdTsdT	sense

997-1016	3679	GGCUCCCCCCGAACCAGCU	3680	GGCUCCCCCCGAACcAGCUdTsdT	antis

1079-1098	3681	UUACACCUCGUCCAUCGAU	3682	uuAcAccucGuccAucGAudTsdT	sense

1079-1098	3683	AUCGAUGGACGAGGUGUAA	3684	AUCGAUGGACGAGGUGuAAdTsdT	antis

1323-1342	3685	AUUGCACUCUGCUCUAGCC	3686	AuuGcAcucuGcucuAGccdTsdT	sense

1323-1342	3687	GGCUAGAGCAGAGUGCAAU	3688	GGCuAGAGcAGAGUGcAAUdTsdT	antis

1370-1389	3689	CUCCCCACUCGAGGCUUGU	3690	cuccccAcucGAGGcuuGudTsdT	sense

1370-1389	3691	ACAAGCCUCGAGUGGGGAG	3692	AcAAGCCUCGAGUGGGGAGdTsdT	antis

1494-1513	3693	CCAUCUCUCAAUGCCAUUC	3694	ccAucucucAAuGccAuucdTsdT	sense

1494-1513	3695	GAAUGGCAUUGAGAGAUGG	3696	GAAUGGcAUUGAGAGAUGGdTsdT	antis

57-76	3697	GGGCGCUGGGCCGGAGCCG	3698	GGGcGcuGGGccGGAGccGdTsdT	sense

57-76	3699	CGGCUCCGGCCCAGCGCCC	3700	CGGCUCCGGCCcAGCGCCCdTsdT	antis

137-156	3701	GGCGGGGGCAGCCCAGGCA	3702	GGcGGGGGcAGcccAGGcAdTsdT	sense

137-156	3703	UGCCUGGGCUGCCCCCGCC	3704	UGCCUGGGCUGCCCCCGCCdTsdT	antis

141-160	3705	GGGGCAGCCCAGGCAGCCC	3706	GGGGcAGcccAGGcAGcccdTsdT	sense

141-160	3707	GGGCUGCCUGGGCUGCCCC	3708	GGGCUGCCUGGGCUGCCCCdTsdT	antis

198-217	3709	GGCGGCGGGCCUUCGGGAG	3710	GGcGGcGGGccuucGGGAGdTsdT	sense

198-217	3711	CUCCCGAAGGCCCGCCGCC	3712	CUCCCGAAGGCCCGCCGCCdTsdT	antis

319-338	3713	CAGGAGGCACUGGCGGCGG	3714	cAGGAGGcAcuGGcGGcGGdTsdT	sense

319-338	3715	CCGCCGCCAGUGCCUCCUG	3716	CCGCCGCcAGUGCCUCCUGdTsdT	antis

417-436	3717	GGCAGCGGUGGCCCCGGCG	3718	GGcAGcGGuGGccccGGcGdTsdT	sense

417-436	3719	CGCCGGGGCCACCGCUGCC	3720	CGCCGGGGCcACCGCUGCCdTsdT	antis

490-509	3721	UGACCACAGUGGUAGCCAC	3722	uGAccAcAGuGGuAGccAcdTsdT	sense

490-509	3723	GUGGCUACCACUGUGGUCA	3724	GUGGCuACcACUGUGGUcAdTsdT	antis

503-522	3725	AGCCACUGUAGGCCAAGGC	3726	AGccAcuGuAGGccAAGGcdTsdT	sense

503-522	3727	GCCUUGGCCUACAGUGGCU	3728	GCCUUGGCCuAcAGUGGCUdTsdT	antis

539-558	3729	AGUGGCUUACACUGACAUC	3730	AGuGGcuuAcAcuGAcAucdTsdT	sense

539-558	3731	GAUGUCAGUGUAAGCCACU	3732	GAUGUcAGUGuAAGCcACUdTsdT	antis

602-621	3733	GCUGGCAGAGACGAGGGAA	3734	GcuGGcAGAGAcGAGGGAAdTsdT	sense

602-621	3735	UUCCCUCGUCUCUGCCAGC	3736	UUCCCUCGUCUCUGCcAGCdTsdT	antis

793-812	3737	CGGUGUACCGAGUGGCCCG	3738	cGGuGuAccGAGuGGcccGdTsdT	sense

793-812	3739	CGGGCCACUCGGUACACCG	3740	CGGGCcACUCGGuAcACCGdTsdT	antis

825-844	3741	GCCAAGCUGAUCACCCCUA	3742	GccAAGcuGAucAccccuAdTsdT	sense

825-844	3743	UAGGGGUGAUCAGCUUGGC	3744	uAGGGGUGAUcAGCUUGGCdTsdT	antis

829-848	3745	AGCUGAUCACCCCUAUCAU	3746	AGcuGAucAccccuAucAudTsdT	sense

829-848	3747	AUGAUAGGGGUGAUCAGCU	3748	AUGAuAGGGGUGAUcAGCUdTsdT	antis

843-862	3749	AUCAUCUACAUCAAGGUGU	3750	AucAucuAcAucAAGGuGudTsdT	sense

843-862	3751	ACACCUUGAUGUAGAUGAU	3752	AcACCUUGAUGuAGAUGAUdTsdT	antis

844-863	3753	UCAUCUACAUCAAGGUGUA	3754	ucAucuAcAucAAGGuGuAdTsdT	sense

844-863	3755	UACACCUUGAUGUAGAUGA	3756	uAcACCUUGAUGuAGAUGAdTsdT	antis

888-907	3757	GCCUACAUCCACUCCCAAG	3758	GccuAcAuccAcucccAAGdTsdT	sense

888-907	3759	CUUGGGAGUGGAUGUAGGC	3760	CUUGGGAGUGGAUGuAGGCdTsdT	antis

902-921	3761	CCAAGGUGUGUGUCACCGU	3762	ccAAGGuGuGuGucAccGudTsdT	sense

902-921	3763	ACGGUGACACACACCUUGG	3764	ACGGUGAcAcAcACCUUGGdTsdT	antis

1067-1086	3765	UGGAGCCACAGAUUACACC	3766	uGGAGccAcAGAuuAcAccdTsdT	sense

1067-1086	3767	GGUGUAAUCUGUGGCUCCA	3768	GGUGuAAUCUGUGGCUCcAdTsdT	antis

1095-1114	3769	GAUGUGUGGUCGGCUGGCU	3770	GAuGuGuGGucGGcuGGcudTsdT	sense

1095-1114	3771	AGCCAGCCGACCACACAUC	3772	AGCcAGCCGACcAcAcAUCdTsdT	antis

1154-1173	3773	UGGGGACAGUGGGGUGGAC	3774	uGGGGAcAGuGGGGuGGAcdTsdT	sense

1154-1173	3775	GUCCACCCCACUGUCCCCA	3776	GUCcACCCcACUGUCCCcAdTsdT	antis

1271-1290	3777	AGCUCACCCUUGGACAAAG	3778	AGcucAcccuuGGAcAAAGdTsdT	sense

1271-1290	3779	CUUUGUCCAAGGGUGAGCU	3780	CUUUGUCcAAGGGUGAGCUdTsdT	antis

1272-1291	3781	GCUCACCCUUGGACAAAGG	3782	GcucAcccuuGGAcAAAGGdTsdT	sense

1272-1291	3783	CCUUUGUCCAAGGGUGAGC	3784	CCUUUGUCcAAGGGUGAGCdTsdT	antis

1289-1308	3785	GGUGUUCAAAUCUUCAAAG	3786	GGuGuucAAAucuucAAAGdTsdT	sense

1289-1308	3787	CUUUGAAGAUUUGAACACC	3788	CUUUGAAGAUUUGAAcACCdTsdT	antis

1324-1343	3789	UUGCACUCUGCUCUAGCCU	3790	uuGcAcucuGcucuAGccudTsdT	sense

1324-1343	3791	AGGCUAGAGCAGAGUGCAA	3792	AGGCuAGAGcAGAGUGcAAdTsdT	antis

1351-1370	3793	ACACGCCAUCCUCAAGGCU	3794	AcAcGccAuccucAAGGcudTsdT	sense

1351-1370	3795	AGCCUUGAGGAUGGCGUGU	3796	AGCCUUGAGGAUGGCGUGUdTsdT	antis

1371-1390	3797	UCCCCACUCGAGGCUUGUG	3798	uccccAcucGAGGcuuGuGdTsdT	sense

1371-1390	3799	CACAAGCCUCGAGUGGGGA	3800	cAcAAGCCUCGAGUGGGGAdTsdT	antis

1392-1411	3801	CACAGCUUCUUCGAUGAAC	3802	cAcAGcuucuucGAuGAAcdTsdT	sense

1392-1411	3803	GUUCAUCGAAGAAGCUGUG	3804	GUUcAUCGAAGAAGCUGUGdTsdT	antis

1395-1414	3805	AGCUUCUUCGAUGAACUGC	3806	AGcuucuucGAuGAAcuGcdTsdT	sense

1395-1414	3807	GCAGUUCAUCGAAGAAGCU	3808	GcAGUUcAUCGAAGAAGCUdTsdT	antis

1439-1458	3809	CGACCGCCCGCUUCCCCCC	3810	cGAccGcccGcuuccccccdTsdT	sense

1439-1458	3811	GGGGGGAAGCGGGCGGUCG	3812	GGGGGGAAGCGGGCGGUCGdTsdT	antis

1442-1461	3813	CCGCCCGCUUCCCCCCCUG	3814	ccGcccGcuucccccccuGdTsdT	sense

1442-1461	3815	CAGGGGGGGAAGCGGGCGG	3816	cAGGGGGGGAAGCGGGCGGdTsdT	antis

1467-1486	3817	UUCAGUCCUGGUGAACUGU	3818	uucAGuccuGGuGAAcuGudTsdT	sense

1467-1486	3819	ACAGUUCACCAGGACUGAA	3820	AcAGUUcACcAGGACUGAAdTsdT	antis

1468-1487	3821	UCAGUCCUGGUGAACUGUC	3822	ucAGuccuGGuGAAcuGucdTsdT	sense

1468-1487	3823	GACAGUUCACCAGGACUGA	3824	GAcAGUUcACcAGGACUGAdTsdT	antis

1482-1501	3825	CUGUCCAUCCAACCAUCUC	3826	cuGuccAuccAAccAucucdTsdT	sense

1482-1501	3827	GAGAUGGUUGGAUGGACAG	3828	GAGAUGGUUGGAUGGAcAGdTsdT	antis

1483-1502	3829	UGUCCAUCCAACCAUCUCU	3830	uGuccAuccAAccAucucudTsdT	sense

1483-1502	3831	AGAGAUGGUUGGAUGGACA	3832	AGAGAUGGUUGGAUGGAcAdTsdT	antis

1495-1514	3833	CAUCUCUCAAUGCCAUUCU	3834	cAucucucAAuGccAuucudTsdT	sense

1495-1514	3835	AGAAUGGCAUUGAGAGAUG	3836	AGAAUGGcAUUGAGAGAUGdTsdT	antis

1554-1573	3837	CCCCUCACCACUUCCUACA	3838	ccccucAccAcuuccuAcAdTsdT	sense

1554-1573	3839	UGUAGGAAGUGGUGAGGGG	3840	UGuAGGAAGUGGUGAGGGGdTsdT	antis

1597-1616	3841	AAGCUCAGACUGGCCAAGA	3842	AAGcucAGAcuGGccAAGAdTsdT	sense

1597-1616	3843	UCUUGGCCAGUCUGAGCUU	3844	UCUUGGCcAGUCUGAGCUUdTsdT	antis

1659-1678	3845	UCCUGAGGGCCCCACCGAC	3846	uccuGAGGGccccAccGAcdTsdT	sense

1659-1678	3847	GUCGGUGGGGCCCUCAGGA	3848	GUCGGUGGGGCCCUcAGGAdTsdT	antis

1814-1833	3849	CAGCAGCCUAACCUCUGUG	3850	cAGcAGccuAAccucuGuGdTsdT	sense

1814-1833	3851	CACAGAGGUUAGGCUGCUG	3852	cAcAGAGGUuAGGCUGCUGdTsdT	antis

1815-1834	3853	AGCAGCCUAACCUCUGUGG	3854	AGcAGccuAAccucuGuGGdTsdT	sense

1815-1834	3855	CCACAGAGGUUAGGCUGCU	3856	CcAcAGAGGUuAGGCUGCUdTsdT	antis

1904-1923	3857	UGAGGACCUUCUACCCCCU	3858	uGAGGAccuucuAcccccudTsdT	sense

1904-1923	3859	AGGGGGUAGAAGGUCCUCA	3860	AGGGGGuAGAAGGUCCUcAdTsdT	antis

1905-1924	3861	GAGGACCUUCUACCCCCUU	3862	GAGGAccuucuAcccccuudTsdT	sense

1905-1924	3863	AAGGGGGUAGAAGGUCCUC	3864	AAGGGGGuAGAAGGUCCUCdTsdT	antis

2012-2031	3865	GUCUUCCCUUCCCUGGCCC	3866	GucuucccuucccuGGcccdTsdT	sense

2012-2031	3867	GGGCCAGGGAAGGGAAGAC	3868	GGGCcAGGGAAGGGAAGACdTsdT	antis

2095-2114	3869	UGCCCCCCCCAGCUGUACC	3870	uGccccccccAGcuGuAccdTsdT	sense

2095-2114	3871	GGUACAGCUGGGGGGGGCA	3872	GGuAcAGCUGGGGGGGGcAdTsdT	antis

2102-2121	3873	CCCAGCUGUACCCCUUCUU	3874	cccAGcuGuAccccuucuudTsdT	sense

2102-2121	3875	AAGAAGGGGUACAGCUGGG	3876	AAGAAGGGGuAcAGCUGGGdTsdT	antis

2184-2203	3877	CUGGUGUCUUAGUUUCCAC	3878	cuGGuGucuuAGuuuccAcdTsdT	sense

2184-2203	3879	GUGGAAACUAAGACACCAG	3880	GUGGAAACuAAGAcACcAGdTsdT	antis

2192-2211	3881	UUAGUUUCCACAGUAAGGU	3882	uuAGuuuccAcAGuAAGGudTsdT	sense

2192-2211	3883	ACCUUACUGUGGAAACUAA	3884	ACCUuACUGUGGAAACuAAdTsdT	antis

2227-2246	3885	CUCUGUUCAAUAAAUUAUU	3886	cucuGuucAAuAAAuuAuudTsdT	sense

2227-2246	3887	AAUAAUUUAUUGAACAGAG	3888	AAuAAUUuAUUGAAcAGAGdTsdT	antis

151-170	3889	AGGCAGCCCGAGCCCCGCG	3890	AGGcAGcccGAGccccGcGdTsdT	sense

151-170	3891	CGCGGGGCUCGGGCUGCCU	3892	CGCGGGGCUCGGGCUGCCUdTsdT	antis

404-423	3893	CAGCGGCGGAGGAGGCAGC	3894	cAGcGGcGGAGGAGGcAGcdTsdT	sense

404-423	3895	GCUGCCUCCUCCGCCGCUG	3896	GCUGCCUCCUCCGCCGCUGdTsdT	antis

530-549	3897	UUCCCAAGAAGUGGCUUAC	3898	uucccAAGAAGuGGcuuAcdTsdT	sense

530-549	3899	GUAAGCCACUUCUUGGGAA	3900	GuAAGCcACUUCUUGGGAAdTsdT	antis

954-973	3901	GACACUGCUGUCCUCAAGC	3902	GAcAcuGcuGuccucAAGcdTsdT	sense

954-973	3903	GCUUGAGGACAGCAGUGUC	3904	GCUUGAGGAcAGcAGUGUCdTsdT	antis

1394-1413	3905	CAGCUUCUUCGAUGAACUG	3906	cAGcuucuucGAuGAAcuGdTsdT	sense

1394-1413	3907	CAGUUCAUCGAAGAAGCUG	3908	cAGUUcAUCGAAGAAGCUGdTsdT	antis

2002-2021	3909	CCCAUCUCUCGUCUUCCCU	3910	cccAucucucGucuucccudTsdT	sense

2002-2021	3911	AGGGAAGACGAGAGAUGGG	3912	AGGGAAGACGAGAGAUGGGdTsdT	antis

2003-2022	3913	CCAUCUCUCGUCUUCCCUU	3914	ccAucucucGucuucccuudTsdT	sense

2003-2022	3915	AAGGGAAGACGAGAGAUGG	3916	AAGGGAAGACGAGAGAUGGdTsdT	antis

2121-2140	3917	GUCCUCUGCUCCCAAGGCU	3918	GuccucuGcucccAAGGcudTsdT	sense

2121-2140	3919	AGCCUUGGGAGCAGAGGAC	3920	AGCCUUGGGAGcAGAGGACdTsdT	antis

24-43	3921	AGAGGGACUUCAUCUCCCG	3922	AGAGGGAcuucAucucccGdTsdT	sense

24-43	3923	CGGGAGAUGAAGUCCCUCU	3924	CGGGAGAUGAAGUCCCUCUdTsdT	antis

49-68	3925	CCCGCGGCGGGCGCUGGGC	3926	cccGcGGcGGGcGcuGGGcdTsdT	sense

49-68	3927	GCCCAGCGCCCGCCGCGGG	3928	GCCcAGCGCCCGCCGCGGGdTsdT	antis

107-126	3929	GAGCCCAGGGGAGGCGGCG	3930	GAGcccAGGGGAGGcGGcGdTsdT	sense

107-126	3931	CGCCGCCUCCCCUGGGCUC	3932	CGCCGCCUCCCCUGGGCUCdTsdT	antis

126-145	3933	GCAGAGGCAGCGGCGGGGG	3934	GcAGAGGcAGcGGcGGGGGdTsdT	sense

126-145	3935	CCCCCGCCGCUGCCUCUGC	3936	CCCCCGCCGCUGCCUCUGCdTsdT	antis

153-172	3937	GCAGCCCGAGCCCCGCGGC	3938	GcAGcccGAGccccGcGGcdTsdT	sense

153-172	3939	GCCGCGGGGCUCGGGCUGC	3940	GCCGCGGGGCUCGGGCUGCdTsdT	antis

259-278	3941	CGGAGCCAGGAGGCGGAGG	3942	cGGAGccAGGAGGcGGAGGdTsdT	sense

259-278	3943	CCUCCGCCUCCUGGCUCCG	3944	CCUCCGCCUCCUGGCUCCGdTsdT	antis

261-280	3945	GAGCCAGGAGGCGGAGGCG	3946	GAGccAGGAGGcGGAGGcGdTsdT	sense

261-280	3947	CGCCUCCGCCUCCUGGCUC	3948	CGCCUCCGCCUCCUGGCUCdTsdT	antis

512-531	3949	AGGCCAAGGCCCAGAGCGU	3950	AGGccAAGGcccAGAGcGudTsdT	sense

512-531	3951	ACGCUCUGGGCCUUGGCCU	3952	ACGCUCUGGGCCUUGGCCUdTsdT	antis

660-679	3953	AAGAACCGAGAACUGCAGA	3954	AAGAAccGAGAAcuGcAGAdTsdT	sense

660-679	3955	UCUGCAGUUCUCGGUUCUU	3956	UCUGcAGUUCUCGGUUCUUdTsdT	antis

709-728	3957	UGAGGCUGCGGUACUUUUU	3958	uGAGGcuGcGGuAcuuuuudTsdT	sense

709-728	3959	AAAAAGUACCGCAGCCUCA	3960	AAAAAGuACCGcAGCCUcAdTsdT	antis

710-729	3961	GAGGCUGCGGUACUUUUUC	3962	GAGGcuGcGGuAcuuuuucdTsdT	sense

710-729	3963	GAAAAAGUACCGCAGCCUC	3964	GAAAAAGuACCGcAGCCUCdTsdT	antis

792-811	3965	ACGGUGUACCGAGUGGCCC	3966	AcGGuGuAccGAGuGGcccdTsdT	sense

792-811	3967	GGGCCACUCGGUACACCGU	3968	GGGCcACUCGGuAcACCGUdTsdT	antis

903-922	3969	CAAGGUGUGUGUCACCGUG	3970	cAAGGuGuGuGucAccGuGdTsdT	sense

903-922	3971	CACGGUGACACACACCUUG	3972	cACGGUGAcAcAcACCUUGdTsdT	antis

1110-1129	3973	GGCUGUGUACUUGCUGAGC	3974	GGcuGuGuAcuuGcuGAGcdTsdT	sense

1110-1129	3975	GCUCAGCAAGUACACAGCC	3976	GCUcAGcAAGuAcAcAGCCdTsdT	antis

1129-1148	3977	UACUUCUCGGCCAGCCCAU	3978	uAcuucucGGccAGcccAudTsdT	sense

1129-1148	3979	AUGGGCUGGCCGAGAAGUA	3980	AUGGGCUGGCCGAGAAGuAdTsdT	antis

1142-1161	3981	GCCCAUCUUCCCUGGGGAC	3982	GcccAucuucccuGGGGAcdTsdT	sense

1142-1161	3983	GUCCCCAGGGAAGAUGGGC	3984	GUCCCcAGGGAAGAUGGGCdTsdT	antis

1153-1172	3985	CUGGGGACAGUGGGGUGGA	3986	cuGGGGAcAGuGGGGuGGAdTsdT	sense

1153-1172	3987	UCCACCCCACUGUCCCCAG	3988	UCcACCCcACUGUCCCcAGdTsdT	antis

1472-1491	3989	UCCUGGUGAACUGUCCAUC	3990	uccuGGuGAAcuGuccAucdTsdT	sense

1472-1491	3991	GAUGGACAGUUCACCAGGA	3992	GAUGGAcAGUUcACcAGGAdTsdT	antis

1473-1492	3993	CCUGGUGAACUGUCCAUCC	3994	ccuGGuGAAcuGuccAuccdTsdT	sense

1473-1492	3995	GGAUGGACAGUUCACCAGG	3996	GGAUGGAcAGUUcACcAGGdTsdT	antis

1652-1671	3997	UAGCUCUUCCUGAGGGCCC	3998	uAGcucuuccuGAGGGcccdTsdT	sense

1652-1671	3999	GGGCCCUCAGGAAGAGCUA	4000	GGGCCCUcAGGAAGAGCuAdTsdT	antis

1653-1672	4001	AGCUCUUCCUGAGGGCCCC	4002	AGcucuuccuGAGGGccccdTsdT	sense

1653-1672	4003	GGGGCCCUCAGGAAGAGCU	4004	GGGGCCCUcAGGAAGAGCUdTsdT	antis

1812-1831	4005	CUCAGCAGCCUAACCUCUG	4006	cucAGcAGccuAAccucuGdTsdT	sense

1812-1831	4007	CAGAGGUUAGGCUGCUGAG	4008	cAGAGGUuAGGCUGCUGAGdTsdT	antis

1952-1971	4009	UCCUUCCCUCCCCCCCUCU	4010	uccuucccucccccccucudTsdT	sense

1952-1971	4011	AGAGGGGGGGAGGGAAGGA	4012	AGAGGGGGGGAGGGAAGGAdTsdT	antis

1968-1987	4013	UCUCCCAGGUCCCUUGUAA	4014	ucucccAGGucccuuGuAAdTsdT	sense

1968-1987	4015	UUACAAGGGACCUGGGAGA	4016	UuAcAAGGGACCUGGGAGAdTsdT	antis

2051-2070	4017	UAUAAUUUUUUCUUAAAGA	4018	uAuAAuuuuuucuuAAAGAdTsdT	sense

2051-2070	4019	UCUUUAAGAAAAAAUUAUA	4020	UCUUuAAGAAAAAAUuAuAdTsdT	antis

2056-2075	4021	UUUUUUCUUAAAGAAAACG	4022	uuuuuucuuAAAGAAAAcGdTsdT	sense

2056-2075	4023	CGUUUUCUUUAAGAAAAAA	4024	CGUUUUCUUuAAGAAAAAAdTsdT	antis

2128-2147	4025	GCUCCCAAGGCUUCCUCCC	4026	GcucccAAGGcuuccucccdTsdT	sense

2128-2147	4027	GGGAGGAAGCCUUGGGAGC	4028	GGGAGGAAGCCUUGGGAGCdTsdT	antis

2135-2154	4029	AGGCUUCCUCCCUCUCCCC	4030	AGGcuuccucccucuccccdTsdT	sense

2135-2154	4031	GGGGAGAGGGAGGAAGCCU	4032	GGGGAGAGGGAGGAAGCCUdTsdT	antis

2136-2155	4033	GGCUUCCUCCCUCUCCCCA	4034	GGcuuccucccucuccccAdTsdT	sense

2136-2155	4035	UGGGGAGAGGGAGGAAGCC	4036	UGGGGAGAGGGAGGAAGCCdTsdT	antis

2147-2166	4037	UCUCCCCAUCCUGGAAGGA	4038	ucuccccAuccuGGAAGGAdTsdT	sense

2147-2166	4039	UCCUUCCAGGAUGGGGAGA	4040	UCCUUCcAGGAUGGGGAGAdTsdT	antis

511-530	4041	UAGGCCAAGGCCCAGAGCG	4042	uAGGccAAGGcccAGAGcGdTsdT	sense

511-530	4043	CGCUCUGGGCCUUGGCCUA	4044	CGCUCUGGGCCUUGGCCuAdTsdT	antis

677-696	4045	GAUUAUGCGUAAGCUGGAC	4046	GAuuAuGcGuAAGcuGGAcdTsdT	sense

677-696	4047	GUCCAGCUUACGCAUAAUC	4048	GUCcAGCUuACGcAuAAUCdTsdT	antis

682-701	4049	UGCGUAAGCUGGACCACUG	4050	uGcGuAAGcuGGAccAcuGdTsdT	sense

682-701	4051	CAGUGGUCCAGCUUACGCA	4052	cAGUGGUCcAGCUuACGcAdTsdT	antis

796-815	4053	UGUACCGAGUGGCCCGCCA	4054	uGuAccGAGuGGcccGccAdTsdT	sense

796-815	4055	UGGCGGGCCACUCGGUACA	4056	UGGCGGGCcACUCGGuAcAdTsdT	antis

750-769	4057	GACGAGCUGUAUUUGAAUC	4058	GAcGAGcuGuAuuuGAAucdTsdT	sense

750-769	4059	GAUUCAAAUACAGCUCGUC	4060	GAUUcAAAuAcAGCUCGUCdTsdT	antis

1646-1665	4061	CCUCGCUAGCUCUUCCUGA	4062	ccucGcuAGcucuuccuGAdTsdT	sense

1646-1665	4063	UCAGGAAGAGCUAGCGAGG	4064	UcAGGAAGAGCuAGCGAGGdTsdT	antis

664-683	4065	ACCGAGAACUGCAGAUUAU	4066	AccGAGAAcuGcAGAuuAudTsdT	sense

664-683	4067	AUAAUCUGCAGUUCUCGGU	4068	AuAAUCUGcAGUUCUCGGUdTsdT	antis

751-770	4069	ACGAGCUGUAUUUGAAUCU	4070	AcGAGcuGuAuuuGAAucudTsdT	sense

751-770	4071	AGAUUCAAAUACAGCUCGU	4072	AGAUUcAAAuAcAGCUCGUdTsdT	antis

835-854	4073	UCACCCCUAUCAUCUACAU	4074	ucAccccuAucAucuAcAudTsdT	sense

835-854	4075	AUGUAGAUGAUAGGGGUGA	4076	AUGuAGAUGAuAGGGGUGAdTsdT	antis

1399-1418	4077	UCUUCGAUGAACUGCGGAG	4078	ucuucGAuGAAcuGcGGAGdTsdT	sense

1399-1418	4079	CUCCGCAGUUCAUCGAAGA	4080	CUCCGcAGUUcAUCGAAGAdTsdT	antis

2175-2194	4081	AGAGAGUCCCUGGUGUCUU	4082	AGAGAGucccuGGuGucuudTsdT	sense

2175-2194	4083	AAGACACCAGGGACUCUCU	4084	AAGAcACcAGGGACUCUCUdTsdT	antis

19-38	4085	ACGGCAGAGGGACUUCAUC	4086	AcGGcAGAGGGAcuucAucdTsdT	sense

19-38	4087	GAUGAAGUCCCUCUGCCGU	4088	GAUGAAGUCCCUCUGCCGUdTsdT	antis

79-98	4089	CCCGAACGGCGCGGCCUGG	4090	cccGAAcGGcGcGGccuGGdTsdT	sense

79-98	4091	CCAGGCCGCGCCGUUCGGG	4092	CcAGGCCGCGCCGUUCGGGdTsdT	antis

186-205	4093	GGCGCCAUGAGCGGCGGCG	4094	GGcGccAuGAGcGGcGGcGdTsdT	sense

186-205	4095	CGCCGCCGCUCAUGGCGCC	4096	CGCCGCCGCUcAUGGCGCCdTsdT	antis

187-206	4097	GCGCCAUGAGCGGCGGCGG	4098	GcGccAuGAGcGGcGGcGGdTsdT	sense

187-206	4099	CCGCCGCCGCUCAUGGCGC	4100	CCGCCGCCGCUcAUGGCGCdTsdT	antis

334-353	4101	GCGGGAAAGCGUCAGUCGG	4102	GcGGGAAAGcGucAGucGGdTsdT	sense

334-353	4103	CCGACUGACGCUUUCCCGC	4104	CCGACUGACGCUUUCCCGCdTsdT	antis

349-368	4105	UCGGGGCUAUGGGUGGGGG	4106	ucGGGGcuAuGGGuGGGGGdTsdT	sense

349-368	4107	CCCCCACCCAUAGCCCCGA	4108	CCCCcACCcAuAGCCCCGAdTsdT	antis

451-470	4109	CGCCGCCGGGAGUGAAGCU	4110	cGccGccGGGAGuGAAGcudTsdT	sense

451-470	4111	AGCUUCACUCCCGGCGGCG	4112	AGCUUcACUCCCGGCGGCGdTsdT	antis

476-495	4113	UGACAGCGGGAAGGUGACC	4114	uGAcAGcGGGAAGGuGAccdTsdT	sense

476-495	4115	GGUCACCUUCCCGCUGUCA	4116	GGUcACCUUCCCGCUGUcAdTsdT	antis

480-499	4117	AGCGGGAAGGUGACCACAG	4118	AGcGGGAAGGuGAccAcAGdTsdT	sense

480-499	4119	CUGUGGUCACCUUCCCGCU	4120	CUGUGGUcACCUUCCCGCUdTsdT	antis

481-500	4121	GCGGGAAGGUGACCACAGU	4122	GcGGGAAGGuGAccAcAGudTsdT	sense

481-500	4123	ACUGUGGUCACCUUCCCGC	4124	ACUGUGGUcACCUUCCCGCdTsdT	antis

516-535	4125	CAAGGCCCAGAGCGUUCCC	4126	cAAGGcccAGAGcGuucccdTsdT	sense

516-535	4127	GGGAACGCUCUGGGCCUUG	4128	GGGAACGCUCUGGGCCUUGdTsdT	antis

586-605	4129	UAGUAUACCAGGCACGGCU	4130	uAGuAuAccAGGcAcGGcudTsdT	sense

586-605	4131	AGCCGUGCCUGGUAUACUA	4132	AGCCGUGCCUGGuAuACuAdTsdT	antis

608-627	4133	AGAGACGAGGGAACUGGUG	4134	AGAGAcGAGGGAAcuGGuGdTsdT	sense

608-627	4135	CACCAGUUCCCUCGUCUCU	4136	cACcAGUUCCCUCGUCUCUdTsdT	antis

662-681	4137	GAACCGAGAACUGCAGAUU	4138	GAAccGAGAAcuGcAGAuudTsdT	sense

662-681	4139	AAUCUGCAGUUCUCGGUUC	4140	AAUCUGcAGUUCUCGGUUCdTsdT	antis

678-697	4141	AUUAUGCGUAAGCUGGACC	4142	AuuAuGcGuAAGcuGGAccdTsdT	sense

678-697	4143	GGUCCAGCUUACGCAUAAU	4144	GGUCcAGCUuACGcAuAAUdTsdT	antis

679-698	4145	UUAUGCGUAAGCUGGACCA	4146	uuAuGcGuAAGcuGGAccAdTsdT	sense

679-698	4147	UGGUCCAGCUUACGCAUAA	4148	UGGUCcAGCUuACGcAuAAdTsdT	antis

680-699	4149	UAUGCGUAAGCUGGACCAC	4150	uAuGcGuAAGcuGGAccAcdTsdT	sense

680-699	4151	GUGGUCCAGCUUACGCAUA	4152	GUGGUCcAGCUuACGcAuAdTsdT	antis

683-702	4153	GCGUAAGCUGGACCACUGC	4154	GcGuAAGcuGGAccAcuGcdTsdT	sense

683-702	4155	GCAGUGGUCCAGCUUACGC	4156	GcAGUGGUCcAGCUuACGCdTsdT	antis

714-733	4157	CUGCGGUACUUUUUCUACU	4158	cuGcGGuAcuuuuucuAcudTsdT	sense

714-733	4159	AGUAGAAAAAGUACCGCAG	4160	AGuAGAAAAAGuACCGcAGdTsdT	antis

715-734	4161	UGCGGUACUUUUUCUACUC	4162	uGcGGuAcuuuuucuAcucdTsdT	sense

715-734	4163	GAGUAGAAAAAGUACCGCA	4164	GAGuAGAAAAAGuACCGcAdTsdT	antis

754-773	4165	AGCUGUAUUUGAAUCUGGU	4166	AGcuGuAuuuGAAucuGGudTsdT	sense

754-773	4167	ACCAGAUUCAAAUACAGCU	4168	ACcAGAUUcAAAuAcAGCUdTsdT	antis

795-814	4169	GUGUACCGAGUGGCCCGCC	4170	GuGuAccGAGuGGcccGccdTsdT	sense

795-814	4171	GGCGGGCCACUCGGUACAC	4172	GGCGGGCcACUCGGuAcACdTsdT	antis

797-816	4173	GUACCGAGUGGCCCGCCAC	4174	GuAccGAGuGGcccGccAcdTsdT	sense

797-816	4175	GUGGCGGGCCACUCGGUAC	4176	GUGGCGGGCcACUCGGuACdTsdT	antis

799-818	4177	ACCGAGUGGCCCGCCACUU	4178	AccGAGuGGcccGccAcuudTsdT	sense

799-818	4179	AAGUGGCGGGCCACUCGGU	4180	AAGUGGCGGGCcACUCGGUdTsdT	antis

800-819	4181	CCGAGUGGCCCGCCACUUC	4182	ccGAGuGGcccGccAcuucdTsdT	sense

800-819	4183	GAAGUGGCGGGCCACUCGG	4184	GAAGUGGCGGGCcACUCGGdTsdT	antis

834-853	4185	AUCACCCCUAUCAUCUACA	4186	AucAccccuAucAucuAcAdTsdT	sense

834-853	4187	UGUAGAUGAUAGGGGUGAU	4188	UGuAGAUGAuAGGGGUGAUdTsdT	antis

845-864	4189	CAUCUACAUCAAGGUGUAC	4190	cAucuAcAucAAGGuGuAcdTsdT	sense

845-864	4191	GUACACCUUGAUGUAGAUG	4192	GuAcACCUUGAUGuAGAUGdTsdT	antis

850-869	4193	ACAUCAAGGUGUACAUGUA	4194	AcAucAAGGuGuAcAuGuAdTsdT	sense

850-869	4195	UACAUGUACACCUUGAUGU	4196	uAcAUGuAcACCUUGAUGUdTsdT	antis

885-904	4197	UUGGCCUACAUCCACUCCC	4198	uuGGccuAcAuccAcucccdTsdT	sense

885-904	4199	GGGAGUGGAUGUAGGCCAA	4200	GGGAGUGGAUGuAGGCcAAdTsdT	antis

890-909	4201	CUACAUCCACUCCCAAGGU	4202	cuAcAuccAcucccAAGGudTsdT	sense

890-909	4203	ACCUUGGGAGUGGAUGUAG	4204	ACCUUGGGAGUGGAUGuAGdTsdT	antis

921-940	4205	GACAUCAAGCCCCAGAAUU	4206	GAcAucAAGccccAGAAuudTsdT	sense

921-940	4207	AAUUCUGGGGCUUGAUGUC	4208	AAUUCUGGGGCUUGAUGUCdTsdT	antis

934-953	4209	AGAAUUUGCUUGUGGACCC	4210	AGAAuuuGcuuGuGGAcccdTsdT	sense

934-953	4211	GGGUCCACAAGCAAAUUCU	4212	GGGUCcAcAAGcAAAUUCUdTsdT	antis

1032-1051	4213	UGCUCUCGGUACUACCGUG	4214	uGcucucGGuAcuAccGuGdTsdT	sense

1032-1051	4215	CACGGUAGUACCGAGAGCA	4216	cACGGuAGuACCGAGAGcAdTsdT	antis

1033-1052	4217	GCUCUCGGUACUACCGUGC	4218	GcucucGGuAcuAccGuGcdTsdT	sense

1033-1052	4219	GCACGGUAGUACCGAGAGC	4220	GcACGGuAGuACCGAGAGCdTsdT	antis

1081-1100	4221	ACACCUCGUCCAUCGAUGU	4222	AcAccucGuccAucGAuGudTsdT	sense

1081-1100	4223	ACAUCGAUGGACGAGGUGU	4224	AcAUCGAUGGACGAGGUGUdTsdT	antis

1082-1101	4225	CACCUCGUCCAUCGAUGUG	4226	cAccucGuccAucGAuGuGdTsdT	sense

1082-1101	4227	CACAUCGAUGGACGAGGUG	4228	cAcAUCGAUGGACGAGGUGdTsdT	antis

1083-1102	4229	ACCUCGUCCAUCGAUGUGU	4230	AccucGuccAucGAuGuGudTsdT	sense

1083-1102	4231	ACACAUCGAUGGACGAGGU	4232	AcAcAUCGAUGGACGAGGUdTsdT	antis

1241-1260	4233	CUAUACGGAGUUCAAGUUC	4234	cuAuAcGGAGuucAAGuucdTsdT	sense

1241-1260	4235	GAACUUGAACUCCGUAUAG	4236	GAACUUGAACUCCGuAuAGdTsdT	antis

1242-1261	4237	UAUACGGAGUUCAAGUUCC	4238	uAuAcGGAGuucAAGuuccdTsdT	sense

1242-1261	4239	GGAACUUGAACUCCGUAUA	4240	GGAACUUGAACUCCGuAuAdTsdT	antis

1243-1262	4241	AUACGGAGUUCAAGUUCCC	4242	AuAcGGAGuucAAGuucccdTsdT	sense

1243-1262	4243	GGGAACUUGAACUCCGUAU	4244	GGGAACUUGAACUCCGuAUdTsdT	antis

1396-1415	4245	GCUUCUUCGAUGAACUGCG	4246	GcuucuucGAuGAAcuGcGdTsdT	sense

1396-1415	4247	CGCAGUUCAUCGAAGAAGC	4248	CGcAGUUcAUCGAAGAAGCdTsdT	antis

1397-1416	4249	CUUCUUCGAUGAACUGCGG	4250	cuucuucGAuGAAcuGcGGdTsdT	sense

1397-1416	4251	CCGCAGUUCAUCGAAGAAG	4252	CCGcAGUUcAUCGAAGAAGdTsdT	antis

1398-1417	4253	UUCUUCGAUGAACUGCGGA	4254	uucuucGAuGAAcuGcGGAdTsdT	sense

1398-1417	4255	UCCGCAGUUCAUCGAAGAA	4256	UCCGcAGUUcAUCGAAGAAdTsdT	antis

1400-1419	4257	CUUCGAUGAACUGCGGAGA	4258	cuucGAuGAAcuGcGGAGAdTsdT	sense

1400-1419	4259	UCUCCGCAGUUCAUCGAAG	4260	UCUCCGcAGUUcAUCGAAGdTsdT	antis

1452-1471	4261	CCCCCCCUGUUCAACUUCA	4262	cccccccuGuucAAcuucAdTsdT	sense

1452-1471	4263	UGAAGUUGAACAGGGGGGG	4264	UGAAGUUGAAcAGGGGGGGdTsdT	antis

1576-1595	4265	CAUCCUCACAAGCUUUAAC	4266	cAuccucAcAAGcuuuAAcdTsdT	sense

1576-1595	4267	GUUAAAGCUUGUGAGGAUG	4268	GUuAAAGCUUGUGAGGAUGdTsdT	antis

1634-1653	4269	CACAACUGCUACCCUCGCU	4270	cAcAAcuGcuAcccucGcudTsdT	sense

1634-1653	4271	AGCGAGGGUAGCAGUUGUG	4272	AGCGAGGGuAGcAGUUGUGdTsdT	antis

1635-1654	4273	ACAACUGCUACCCUCGCUA	4274	AcAAcuGcuAcccucGcuAdTsdT	sense

1635-1654	4275	UAGCGAGGGUAGCAGUUGU	4276	uAGCGAGGGuAGcAGUUGUdTsdT	antis

1643-1662	4277	UACCCUCGCUAGCUCUUCC	4278	uAcccucGcuAGcucuuccdTsdT	sense

1643-1662	4279	GGAAGAGCUAGCGAGGGUA	4280	GGAAGAGCuAGCGAGGGuAdTsdT	antis

1645-1664	4281	CCCUCGCUAGCUCUUCCUG	4282	cccucGcuAGcucuuccuGdTsdT	sense

1645-1664	4283	CAGGAAGAGCUAGCGAGGG	4284	cAGGAAGAGCuAGCGAGGGdTsdT	antis

1660-1679	4285	CCUGAGGGCCCCACCGACU	4286	ccuGAGGGccccAccGAcudTsdT	sense

1660-1679	4287	AGUCGGUGGGGCCCUCAGG	4288	AGUCGGUGGGGCCCUcAGGdTsdT	antis

1664-1683	4289	AGGGCCCCACCGACUACCC	4290	AGGGccccAccGAcuAcccdTsdT	sense

1664-1683	4291	GGGUAGUCGGUGGGGCCCU	4292	GGGuAGUCGGUGGGGCCCUdTsdT	antis

1665-1684	4293	GGGCCCCACCGACUACCCC	4294	GGGccccAccGAcuAccccdTsdT	sense

1665-1684	4295	GGGGUAGUCGGUGGGGCCC	4296	GGGGuAGUCGGUGGGGCCCdTsdT	antis

1816-1835	4297	GCAGCCUAACCUCUGUGGU	4298	GcAGccuAAccucuGuGGudTsdT	sense

1816-1835	4299	ACCACAGAGGUUAGGCUGC	4300	ACcAcAGAGGUuAGGCUGCdTsdT	antis

1817-1836	4301	CAGCCUAACCUCUGUGGUG	4302	cAGccuAAccucuGuGGuGdTsdT	sense

1817-1836	4303	CACCACAGAGGUUAGGCUG	4304	cACcAcAGAGGUuAGGCUGdTsdT	antis

1973-1992	4305	CAGGUCCCUUGUAAAUAGA	4306	cAGGucccuuGuAAAuAGAdTsdT	sense

1973-1992	4307	UCUAUUUACAAGGGACCUG	4308	UCuAUUuAcAAGGGACCUGdTsdT	antis

2206-2225	4309	AAGGUUUGCCUGUGUACAG	4310	AAGGuuuGccuGuGuAcAGdTsdT	sense

2206-2225	4311	CUGUACACAGGCAAACCUU	4312	CUGuAcAcAGGcAAACCUUdTsdT	antis

2207-2226	4313	AGGUUUGCCUGUGUACAGA	4314	AGGuuuGccuGuGuAcAGAdTsdT	sense

2207-2226	4315	UCUGUACACAGGCAAACCU	4316	UCUGuAcAcAGGcAAACCUdTsdT	antis

2222-2241	4317	CAGACCUCUGUUCAAUAAA	4318	cAGAccucuGuucAAuAAAdTsdT	sense

2222-2241	4319	UUUAUUGAACAGAGGUCUG	4320	UUuAUUGAAcAGAGGUCUGdTsdT	antis

542-561	4321	GGCUUACACUGACAUCAAA	4322	GGcuuAcAcuGAcAucAAAdTsdT	sense

542-561	4323	UUUGAUGUCAGUGUAAGCC	4324	UUUGAUGUcAGUGuAAGCCdTsdT	antis

681-700	4325	AUGCGUAAGCUGGACCACU	4326	AuGcGuAAGcuGGAccAcudTsdT	sense

681-700	4327	AGUGGUCCAGCUUACGCAU	4328	AGUGGUCcAGCUuACGcAUdTsdT	antis

748-767	4329	AGGACGAGCUGUAUUUGAA	4330	AGGAcGAGcuGuAuuuGAAdTsdT	sense

748-767	4331	UUCAAAUACAGCUCGUCCU	4332	UUcAAAuAcAGCUCGUCCUdTsdT	antis

749-768	4333	GGACGAGCUGUAUUUGAAU	4334	GGAcGAGcuGuAuuuGAAudTsdT	sense

749-768	4335	AUUCAAAUACAGCUCGUCC	4336	AUUcAAAuAcAGCUCGUCCdTsdT	antis

1352-1371	4337	CACGCCAUCCUCAAGGCUC	4338	cAcGccAuccucAAGGcucdTsdT	sense

1352-1371	4339	GAGCCUUGAGGAUGGCGUG	4340	GAGCCUUGAGGAUGGCGUGdTsdT	antis

1944-1963	4341	GCUACCACUCCUUCCCUCC	4342	GcuAccAcuccuucccuccdTsdT	sense

1944-1963	4343	GGAGGGAAGGAGUGGUAGC	4344	GGAGGGAAGGAGUGGuAGCdTsdT	antis

2004-2023	4345	CAUCUCUCGUCUUCCCUUC	4346	cAucucucGucuucccuucdTsdT	sense

2004-2023	4347	GAAGGGAAGACGAGAGAUG	4348	GAAGGGAAGACGAGAGAUGdTsdT	antis

348-367	4349	GUCGGGGCUAUGGGUGGGG	4350	GucGGGGcuAuGGGuGGGGdTsdT	sense

348-367	4351	CCCCACCCAUAGCCCCGAC	4352	CCCcACCcAuAGCCCCGACdTsdT	antis

39-58	4353	CCCGGCGUGCCCCGCGGCG	4354	cccGGcGuGccccGcGGcGdTsdT	sense

39-58	4355	CGCCGCGGGGCACGCCGGG	4356	CGCCGCGGGGcACGCCGGGdTsdT	antis

184-203	4357	UCGGCGCCAUGAGCGGCGG	4358	ucGGcGccAuGAGcGGcGGdTsdT	sense

184-203	4359	CCGCCGCUCAUGGCGCCGA	4360	CCGCCGCUcAUGGCGCCGAdTsdT	antis

344-363	4361	GUCAGUCGGGGCUAUGGGU	4362	GucAGucGGGGcuAuGGGudTsdT	sense

344-363	4363	ACCCAUAGCCCCGACUGAC	4364	ACCcAuAGCCCCGACUGACdTsdT	antis

347-366	4365	AGUCGGGGCUAUGGGUGGG	4366	AGucGGGGcuAuGGGuGGGdTsdT	sense

347-366	4367	CCCACCCAUAGCCCCGACU	4368	CCcACCcAuAGCCCCGACUdTsdT	antis

454-473	4369	CGCCGGGAGUGAAGCUGGG	4370	cGccGGGAGuGAAGcuGGGdTsdT	sense

454-473	4371	CCCAGCUUCACUCCCGGCG	4372	CCcAGCUUcACUCCCGGCGdTsdT	antis

456-475	4373	CCGGGAGUGAAGCUGGGCC	4374	ccGGGAGuGAAGcuGGGccdTsdT	sense

456-475	4375	GGCCCAGCUUCACUCCCGG	4376	GGCCcAGCUUcACUCCCGGdTsdT	antis

477-496	4377	GACAGCGGGAAGGUGACCA	4378	GAcAGcGGGAAGGuGAccAdTsdT	sense

477-496	4379	UGGUCACCUUCCCGCUGUC	4380	UGGUcACCUUCCCGCUGUCdTsdT	antis

479-498	4381	CAGCGGGAAGGUGACCACA	4382	cAGcGGGAAGGuGAccAcAdTsdT	sense

479-498	4383	UGUGGUCACCUUCCCGCUG	4384	UGUGGUcACCUUCCCGCUGdTsdT	antis

517-536	4385	AAGGCCCAGAGCGUUCCCA	4386	AAGGcccAGAGcGuucccAdTsdT	sense

517-536	4387	UGGGAACGCUCUGGGCCUU	4388	UGGGAACGCUCUGGGCCUUdTsdT	antis

518-537	4389	AGGCCCAGAGCGUUCCCAA	4390	AGGcccAGAGcGuucccAAdTsdT	sense

518-537	4391	UUGGGAACGCUCUGGGCCU	4392	UUGGGAACGCUCUGGGCCUdTsdT	antis

519-538	4393	GGCCCAGAGCGUUCCCAAG	4394	GGcccAGAGcGuucccAAGdTsdT	sense

519-538	4395	CUUGGGAACGCUCUGGGCC	4396	CUUGGGAACGCUCUGGGCCdTsdT	antis

544-563	4397	CUUACACUGACAUCAAAGU	4398	cuuAcAcuGAcAucAAAGudTsdT	sense

544-563	4399	ACUUUGAUGUCAGUGUAAG	4400	ACUUUGAUGUcAGUGuAAGdTsdT	antis

545-564	4401	UUACACUGACAUCAAAGUG	4402	uuAcAcuGAcAucAAAGuGdTsdT	sense

545-564	4403	CACUUUGAUGUCAGUGUAA	4404	cACUUUGAUGUcAGUGuAAdTsdT	antis

603-622	4405	CUGGCAGAGACGAGGGAAC	4406	cuGGcAGAGAcGAGGGAAcdTsdT	sense

603-622	4407	GUUCCCUCGUCUCUGCCAG	4408	GUUCCCUCGUCUCUGCcAGdTsdT	antis

604-623	4409	UGGCAGAGACGAGGGAACU	4410	uGGcAGAGAcGAGGGAAcudTsdT	sense

604-623	4411	AGUUCCCUCGUCUCUGCCA	4412	AGUUCCCUCGUCUCUGCcAdTsdT	antis

741-760	4413	GAGAAGAAGGACGAGCUGU	4414	GAGAAGAAGGAcGAGcuGudTsdT	sense

741-760	4415	ACAGCUCGUCCUUCUUCUC	4416	AcAGCUCGUCCUUCUUCUCdTsdT	antis

752-771	4417	CGAGCUGUAUUUGAAUCUG	4418	cGAGcuGuAuuuGAAucuGdTsdT	sense

752-771	4419	CAGAUUCAAAUACAGCUCG	4420	cAGAUUcAAAuAcAGCUCGdTsdT	antis

753-772	4421	GAGCUGUAUUUGAAUCUGG	4422	GAGcuGuAuuuGAAucuGGdTsdT	sense

753-772	4423	CCAGAUUCAAAUACAGCUC	4424	CcAGAUUcAAAuAcAGCUCdTsdT	antis

831-850	4425	CUGAUCACCCCUAUCAUCU	4426	cuGAucAccccuAucAucudTsdT	sense

831-850	4427	AGAUGAUAGGGGUGAUCAG	4428	AGAUGAuAGGGGUGAUcAGdTsdT	antis

832-851	4429	UGAUCACCCCUAUCAUCUA	4430	uGAucAccccuAucAucuAdTsdT	sense

832-851	4431	UAGAUGAUAGGGGUGAUCA	4432	uAGAUGAuAGGGGUGAUcAdTsdT	antis

833-852	4433	GAUCACCCCUAUCAUCUAC	4434	GAucAccccuAucAucuAcdTsdT	sense

833-852	4435	GUAGAUGAUAGGGGUGAUC	4436	GuAGAUGAuAGGGGUGAUCdTsdT	antis

913-932	4437	GUCACCGUGACAUCAAGCC	4438	GucAccGuGAcAucAAGccdTsdT	sense

913-932	4439	GGCUUGAUGUCACGGUGAC	4440	GGCUUGAUGUcACGGUGACdTsdT	antis

918-937	4441	CGUGACAUCAAGCCCCAGA	4442	cGuGAcAucAAGccccAGAdTsdT	sense

918-937	4443	UCUGGGGCUUGAUGUCACG	4444	UCUGGGGCUUGAUGUcACGdTsdT	antis

920-939	4445	UGACAUCAAGCCCCAGAAU	4446	uGAcAucAAGccccAGAAudTsdT	sense

920-939	4447	AUUCUGGGGCUUGAUGUCA	4448	AUUCUGGGGCUUGAUGUcAdTsdT	antis

1018-1037	4449	AUGUGUCCUACAUCUGCUC	4450	AuGuGuccuAcAucuGcucdTsdT	sense

1018-1037	4451	GAGCAGAUGUAGGACACAU	4452	GAGcAGAUGuAGGAcAcAUdTsdT	antis

1019-1038	4453	UGUGUCCUACAUCUGCUCU	4454	uGuGuccuAcAucuGcucudTsdT	sense

1019-1038	4455	AGAGCAGAUGUAGGACACA	4456	AGAGcAGAUGuAGGAcAcAdTsdT	antis

1097-1116	4457	UGUGUGGUCGGCUGGCUGU	4458	uGuGuGGucGGcuGGcuGudTsdT	sense

1097-1116	4459	ACAGCCAGCCGACCACACA	4460	AcAGCcAGCCGACcAcAcAdTsdT	antis

1102-1121	4461	GGUCGGCUGGCUGUGUACU	4462	GGucGGcuGGcuGuGuAcudTsdT	sense

1102-1121	4463	AGUACACAGCCAGCCGACC	4464	AGuAcAcAGCcAGCCGACCdTsdT	antis

1155-1174	4465	GGGGACAGUGGGGUGGACC	4466	GGGGAcAGuGGGGuGGAccdTsdT	sense

1155-1174	4467	GGUCCACCCCACUGUCCCC	4468	GGUCcACCCcACUGUCCCCdTsdT	antis

1245-1264	4469	ACGGAGUUCAAGUUCCCCC	4470	AcGGAGuucAAGuucccccdTsdT	sense

1245-1264	4471	GGGGGAACUUGAACUCCGU	4472	GGGGGAACUUGAACUCCGUdTsdT	antis

1274-1293	4473	UCACCCUUGGACAAAGGUG	4474	ucAcccuuGGAcAAAGGuGdTsdT	sense

1274-1293	4475	CACCUUUGUCCAAGGGUGA	4476	cACCUUUGUCcAAGGGUGAdTsdT	antis

1276-1295	4477	ACCCUUGGACAAAGGUGUU	4478	AcccuuGGAcAAAGGuGuudTsdT	sense

1276-1295	4479	AACACCUUUGUCCAAGGGU	4480	AAcACCUUUGUCcAAGGGUdTsdT	antis

1316-1335	4481	UGAGGCCAUUGCACUCUGC	4482	uGAGGccAuuGcAcucuGcdTsdT	sense

1316-1335	4483	GCAGAGUGCAAUGGCCUCA	4484	GcAGAGUGcAAUGGCCUcAdTsdT	antis

1318-1337	4485	AGGCCAUUGCACUCUGCUC	4486	AGGccAuuGcAcucuGcucdTsdT	sense

1318-1337	4487	GAGCAGAGUGCAAUGGCCU	4488	GAGcAGAGUGcAAUGGCCUdTsdT	antis

1321-1340	4489	CCAUUGCACUCUGCUCUAG	4490	ccAuuGcAcucuGcucuAGdTsdT	sense

1321-1340	4491	CUAGAGCAGAGUGCAAUGG	4492	CuAGAGcAGAGUGcAAUGGdTsdT	antis

1325-1344	4493	UGCACUCUGCUCUAGCCUA	4494	uGcAcucuGcucuAGccuAdTsdT	sense

1325-1344	4495	UAGGCUAGAGCAGAGUGCA	4496	uAGGCuAGAGcAGAGUGcAdTsdT	antis

1337-1356	4497	UAGCCUACUGGAGUACACG	4498	uAGccuAcuGGAGuAcAcGdTsdT	sense

1337-1356	4499	CGUGUACUCCAGUAGGCUA	4500	CGUGuACUCcAGuAGGCuAdTsdT	antis

1375-1394	4501	CACUCGAGGCUUGUGCCCA	4502	cAcucGAGGcuuGuGcccAdTsdT	sense

1375-1394	4503	UGGGCACAAGCCUCGAGUG	4504	UGGGcAcAAGCCUCGAGUGdTsdT	antis

1443-1462	4505	CGCCCGCUUCCCCCCCUGU	4506	cGcccGcuucccccccuGudTsdT	sense

1443-1462	4507	ACAGGGGGGGAAGCGGGCG	4508	AcAGGGGGGGAAGCGGGCGdTsdT	antis

1466-1485	4509	CUUCAGUCCUGGUGAACUG	4510	cuucAGuccuGGuGAAcuGdTsdT	sense

1466-1485	4511	CAGUUCACCAGGACUGAAG	4512	cAGUUcACcAGGACUGAAGdTsdT	antis

1581-1600	4513	UCACAAGCUUUAACUGAAG	4514	ucAcAAGcuuuAAcuGAAGdTsdT	sense

1581-1600	4515	CUUCAGUUAAAGCUUGUGA	4516	CUUcAGUuAAAGCUUGUGAdTsdT	antis

1602-1621	4517	CAGACUGGCCAAGAUUGGC	4518	cAGAcuGGccAAGAuuGGcdTsdT	sense

1602-1621	4519	GCCAAUCUUGGCCAGUCUG	4520	GCcAAUCUUGGCcAGUCUGdTsdT	antis

1603-1622	4521	AGACUGGCCAAGAUUGGCA	4522	AGAcuGGccAAGAuuGGcAdTsdT	sense

1603-1622	4523	UGCCAAUCUUGGCCAGUCU	4524	UGCcAAUCUUGGCcAGUCUdTsdT	antis

1644-1663	4525	ACCCUCGCUAGCUCUUCCU	4526	AcccucGcuAGcucuuccudTsdT	sense

1644-1663	4527	AGGAAGAGCUAGCGAGGGU	4528	AGGAAGAGCuAGCGAGGGUdTsdT	antis

1666-1685	4529	GGCCCCACCGACUACCCCU	4530	GGccccAccGAcuAccccudTsdT	sense

1666-1685	4531	AGGGGUAGUCGGUGGGGCC	4532	AGGGGuAGUCGGUGGGGCCdTsdT	antis

1820-1839	4533	CCUAACCUCUGUGGUGGGC	4534	ccuAAccucuGuGGuGGGcdTsdT	sense

1820-1839	4535	GCCCACCACAGAGGUUAGG	4536	GCCcACcAcAGAGGUuAGGdTsdT	antis

1821-1840	4537	CUAACCUCUGUGGUGGGCU	4538	cuAAccucuGuGGuGGGcudTsdT	sense

1821-1840	4539	AGCCCACCACAGAGGUUAG	4540	AGCCcACcAcAGAGGUuAGdTsdT	antis

1855-1874	4541	UAACUGUUUGUAGGGGAGG	4542	uAAcuGuuuGuAGGGGAGGdTsdT	sense

1855-1874	4543	CCUCCCCUACAAACAGUUA	4544	CCUCCCCuAcAAAcAGUuAdTsdT	antis

1861-1880	4545	UUUGUAGGGGAGGGGAGAA	4546	uuuGuAGGGGAGGGGAGAAdTsdT	sense

1861-1880	4547	UUCUCCCCUCCCCUACAAA	4548	UUCUCCCCUCCCCuAcAAAdTsdT	antis

1912-1931	4549	UUCUACCCCCUUGGUCCCC	4550	uucuAcccccuuGGuccccdTsdT	sense

1912-1931	4551	GGGGACCAAGGGGGUAGAA	4552	GGGGACcAAGGGGGuAGAAdTsdT	antis

1960-1979	4553	UCCCCCCCUCUCCCAGGUC	4554	ucccccccucucccAGGucdTsdT	sense

1960-1979	4555	GACCUGGGAGAGGGGGGGA	4556	GACCUGGGAGAGGGGGGGAdTsdT	antis

2009-2028	4557	CUCGUCUUCCCUUCCCUGG	4558	cucGucuucccuucccuGGdTsdT	sense

2009-2028	4559	CCAGGGAAGGGAAGACGAG	4560	CcAGGGAAGGGAAGACGAGdTsdT	antis

2010-2029	4561	UCGUCUUCCCUUCCCUGGC	4562	ucGucuucccuucccuGGcdTsdT	sense

2010-2029	4563	GCCAGGGAAGGGAAGACGA	4564	GCcAGGGAAGGGAAGACGAdTsdT	antis

2011-2030	4565	CGUCUUCCCUUCCCUGGCC	4566	cGucuucccuucccuGGccdTsdT	sense

2011-2030	4567	GGCCAGGGAAGGGAAGACG	4568	GGCcAGGGAAGGGAAGACGdTsdT	antis

2223-2242	4569	AGACCUCUGUUCAAUAAAU	4570	AGAccucuGuucAAuAAAudTsdT	sense

2223-2242	4571	AUUUAUUGAACAGAGGUCU	4572	AUUuAUUGAAcAGAGGUCUdTsdT	antis

2226-2245	4573	CCUCUGUUCAAUAAAUUAU	4574	ccucuGuucAAuAAAuuAudTsdT	sense

2226-2245	4575	AUAAUUUAUUGAACAGAGG	4576	AuAAUUuAUUGAAcAGAGGdTsdT	antis

2228-2247	4577	UCUGUUCAAUAAAUUAUUG	4578	ucuGuucAAuAAAuuAuuGdTsdT	sense

2228-2247	4579	CAAUAAUUUAUUGAACAGA	4580	cAAuAAUUuAUUGAAcAGAdTsdT	antis

9-28	4581	AACGAAGCCGACGGCAGAG	4582	AAcGAAGccGAcGGcAGAGdTsdT	sense

9-28	4583	CUCUGCCGUCGGCUUCGUU	4584	CUCUGCCGUCGGCUUCGUUdTsdT	antis

10-29	4585	ACGAAGCCGACGGCAGAGG	4586	AcGAAGccGAcGGcAGAGGdTsdT	sense

10-29	4587	CCUCUGCCGUCGGCUUCGU	4588	CCUCUGCCGUCGGCUUCGUdTsdT	antis

20-39	4589	CGGCAGAGGGACUUCAUCU	4590	cGGcAGAGGGAcuucAucudTsdT	sense

20-39	4591	AGAUGAAGUCCCUCUGCCG	4592	AGAUGAAGUCCCUCUGCCGdTsdT	antis

26-45	4593	AGGGACUUCAUCUCCCGGC	4594	AGGGAcuucAucucccGGcdTsdT	sense

26-45	4595	GCCGGGAGAUGAAGUCCCU	4596	GCCGGGAGAUGAAGUCCCUdTsdT	antis

27-46	4597	GGGACUUCAUCUCCCGGCG	4598	GGGAcuucAucucccGGcGdTsdT	sense

27-46	4599	CGCCGGGAGAUGAAGUCCC	4600	CGCCGGGAGAUGAAGUCCCdTsdT	antis

28-47	4601	GGACUUCAUCUCCCGGCGU	4602	GGAcuucAucucccGGcGudTsdT	sense

28-47	4603	ACGCCGGGAGAUGAAGUCC	4604	ACGCCGGGAGAUGAAGUCCdTsdT	antis

29-48	4605	GACUUCAUCUCCCGGCGUG	4606	GAcuucAucucccGGcGuGdTsdT	sense

29-48	4607	CACGCCGGGAGAUGAAGUC	4608	cACGCCGGGAGAUGAAGUCdTsdT	antis

37-56	4609	CUCCCGGCGUGCCCCGCGG	4610	cucccGGcGuGccccGcGGdTsdT	sense

37-56	4611	CCGCGGGGCACGCCGGGAG	4612	CCGCGGGGcACGCCGGGAGdTsdT	antis

38-57	4613	UCCCGGCGUGCCCCGCGGC	4614	ucccGGcGuGccccGcGGcdTsdT	sense

38-57	4615	GCCGCGGGGCACGCCGGGA	4616	GCCGCGGGGcACGCCGGGAdTsdT	antis

42-61	4617	GGCGUGCCCCGCGGCGGGC	4618	GGcGuGccccGcGGcGGGcdTsdT	sense

42-61	4619	GCCCGCCGCGGGGCACGCC	4620	GCCCGCCGCGGGGcACGCCdTsdT	antis

43-62	4621	GCGUGCCCCGCGGCGGGCG	4622	GcGuGccccGcGGcGGGcGdTsdT	sense

43-62	4623	CGCCCGCCGCGGGGCACGC	4624	CGCCCGCCGCGGGGcACGCdTsdT	antis

59-78	4625	GCGCUGGGCCGGAGCCGGA	4626	GcGcuGGGccGGAGccGGAdTsdT	sense

59-78	4627	UCCGGCUCCGGCCCAGCGC	4628	UCCGGCUCCGGCCcAGCGCdTsdT	antis

60-79	4629	CGCUGGGCCGGAGCCGGAG	4630	cGcuGGGccGGAGccGGAGdTsdT	sense

60-79	4631	CUCCGGCUCCGGCCCAGCG	4632	CUCCGGCUCCGGCCcAGCGdTsdT	antis

99-118	4633	AGAGGCCGGAGCCCAGGGG	4634	AGAGGccGGAGcccAGGGGdTsdT	sense

99-118	4635	CCCCUGGGCUCCGGCCUCU	4636	CCCCUGGGCUCCGGCCUCUdTsdT	antis

108-127	4637	AGCCCAGGGGAGGCGGCGG	4638	AGcccAGGGGAGGcGGcGGdTsdT	sense

108-127	4639	CCGCCGCCUCCCCUGGGCU	4640	CCGCCGCCUCCCCUGGGCUdTsdT	antis

109-128	4641	GCCCAGGGGAGGCGGCGGC	4642	GcccAGGGGAGGcGGcGGcdTsdT	sense

109-128	4643	GCCGCCGCCUCCCCUGGGC	4644	GCCGCCGCCUCCCCUGGGCdTsdT	antis

133-152	4645	CAGCGGCGGGGGCAGCCCA	4646	cAGcGGcGGGGGcAGcccAdTsdT	sense

133-152	4647	UGGGCUGCCCCCGCCGCUG	4648	UGGGCUGCCCCCGCCGCUGdTsdT	antis

135-154	4649	GCGGCGGGGGCAGCCCAGG	4650	GcGGcGGGGGcAGcccAGGdTsdT	sense

135-154	4651	CCUGGGCUGCCCCCGCCGC	4652	CCUGGGCUGCCCCCGCCGCdTsdT	antis

136-155	4653	CGGCGGGGGCAGCCCAGGC	4654	cGGcGGGGGcAGcccAGGcdTsdT	sense

136-155	4655	GCCUGGGCUGCCCCCGCCG	4656	GCCUGGGCUGCCCCCGCCGdTsdT	antis

140-159	4657	GGGGGCAGCCCAGGCAGCC	4658	GGGGGcAGcccAGGcAGccdTsdT	sense

140-159	4659	GGCUGCCUGGGCUGCCCCC	4660	GGCUGCCUGGGCUGCCCCCdTsdT	antis

165-184	4661	CCGCGGCCUGGGCCUGCGC	4662	ccGcGGccuGGGccuGcGcdTsdT	sense

165-184	4663	GCGCAGGCCCAGGCCGCGG	4664	GCGcAGGCCcAGGCCGCGGdTsdT	antis

170-189	4665	GCCUGGGCCUGCGCUCGGC	4666	GccuGGGccuGcGcucGGcdTsdT	sense

170-189	4667	GCCGAGCGCAGGCCCAGGC	4668	GCCGAGCGcAGGCCcAGGCdTsdT	antis

171-190	4669	CCUGGGCCUGCGCUCGGCG	4670	ccuGGGccuGcGcucGGcGdTsdT	sense

171-190	4671	CGCCGAGCGCAGGCCCAGG	4672	CGCCGAGCGcAGGCCcAGGdTsdT	antis

185-204	4673	CGGCGCCAUGAGCGGCGGC	4674	cGGcGccAuGAGcGGcGGcdTsdT	sense

185-204	4675	GCCGCCGCUCAUGGCGCCG	4676	GCCGCCGCUcAUGGCGCCGdTsdT	antis

201-220	4677	GGCGGGCCUUCGGGAGGCG	4678	GGcGGGccuucGGGAGGcGdTsdT	sense

201-220	4679	CGCCUCCCGAAGGCCCGCC	4680	CGCCUCCCGAAGGCCCGCCdTsdT	antis

214-233	4681	GAGGCGGCCCUGGGGGCUC	4682	GAGGcGGcccuGGGGGcucdTsdT	sense

214-233	4683	GAGCCCCCAGGGCCGCCUC	4684	GAGCCCCcAGGGCCGCCUCdTsdT	antis

215-234	4685	AGGCGGCCCUGGGGGCUCG	4686	AGGcGGcccuGGGGGcucGdTsdT	sense

215-234	4687	CGAGCCCCCAGGGCCGCCU	4688	CGAGCCCCcAGGGCCGCCUdTsdT	antis

216-235	4689	GGCGGCCCUGGGGGCUCGG	4690	GGcGGcccuGGGGGcucGGdTsdT	sense

216-235	4691	CCGAGCCCCCAGGGCCGCC	4692	CCGAGCCCCcAGGGCCGCCdTsdT	antis

227-246	4693	GGGCUCGGGCCGGGCGCGG	4694	GGGcucGGGccGGGcGcGGdTsdT	sense

227-246	4695	CCGCGCCCGGCCCGAGCCC	4696	CCGCGCCCGGCCCGAGCCCdTsdT	antis

229-248	4697	GCUCGGGCCGGGCGCGGAC	4698	GcucGGGccGGGcGcGGAcdTsdT	sense

229-248	4699	GUCCGCGCCCGGCCCGAGC	4700	GUCCGCGCCCGGCCCGAGCdTsdT	antis

230-249	4701	CUCGGGCCGGGCGCGGACC	4702	cucGGGccGGGcGcGGAccdTsdT	sense

230-249	4703	GGUCCGCGCCCGGCCCGAG	4704	GGUCCGCGCCCGGCCCGAGdTsdT	antis

290-309	4705	CGGCGGCCCCGGGGGCUCG	4706	cGGcGGccccGGGGGcucGdTsdT	sense

290-309	4707	CGAGCCCCCGGGGCCGCCG	4708	CGAGCCCCCGGGGCCGCCGdTsdT	antis

292-311	4709	GCGGCCCCGGGGGCUCGGC	4710	GcGGccccGGGGGcucGGcdTsdT	sense

292-311	4711	GCCGAGCCCCCGGGGCCGC	4712	GCCGAGCCCCCGGGGCCGCdTsdT	antis

293-312	4713	CGGCCCCGGGGGCUCGGCC	4714	cGGccccGGGGGcucGGccdTsdT	sense

293-312	4715	GGCCGAGCCCCCGGGGCCG	4716	GGCCGAGCCCCCGGGGCCGdTsdT	antis

299-318	4717	CGGGGGCUCGGCCUCUGGC	4718	cGGGGGcucGGccucuGGcdTsdT	sense

299-318	4719	GCCAGAGGCCGAGCCCCCG	4720	GCcAGAGGCCGAGCCCCCGdTsdT	antis

300-319	4721	GGGGGCUCGGCCUCUGGCC	4722	GGGGGcucGGccucuGGccdTsdT	sense

300-319	4723	GGCCAGAGGCCGAGCCCCC	4724	GGCcAGAGGCCGAGCCCCCdTsdT	antis

302-321	4725	GGGCUCGGCCUCUGGCCCA	4726	GGGcucGGccucuGGcccAdTsdT	sense

302-321	4727	UGGGCCAGAGGCCGAGCCC	4728	UGGGCcAGAGGCCGAGCCCdTsdT	antis

304-323	4729	GCUCGGCCUCUGGCCCAGG	4730	GcucGGccucuGGcccAGGdTsdT	sense

304-323	4731	CCUGGGCCAGAGGCCGAGC	4732	CCUGGGCcAGAGGCCGAGCdTsdT	antis

305-324	4733	CUCGGCCUCUGGCCCAGGA	4734	cucGGccucuGGcccAGGAdTsdT	sense

305-324	4735	UCCUGGGCCAGAGGCCGAG	4736	UCCUGGGCcAGAGGCCGAGdTsdT	antis

306-325	4737	UCGGCCUCUGGCCCAGGAG	4738	ucGGccucuGGcccAGGAGdTsdT	sense

306-325	4739	CUCCUGGGCCAGAGGCCGA	4740	CUCCUGGGCcAGAGGCCGAdTsdT	antis

307-326	4741	CGGCCUCUGGCCCAGGAGG	4742	cGGccucuGGcccAGGAGGdTsdT	sense

307-326	4743	CCUCCUGGGCCAGAGGCCG	4744	CCUCCUGGGCcAGAGGCCGdTsdT	antis

322-341	4745	GAGGCACUGGCGGCGGGAA	4746	GAGGcAcuGGcGGcGGGAAdTsdT	sense

322-341	4747	UUCCCGCCGCCAGUGCCUC	4748	UUCCCGCCGCcAGUGCCUCdTsdT	antis

339-358	4749	AAAGCGUCAGUCGGGGCUA	4750	AAAGcGucAGucGGGGcuAdTsdT	sense

339-358	4751	UAGCCCCGACUGACGCUUU	4752	uAGCCCCGACUGACGCUUUdTsdT	antis

345-364	4753	UCAGUCGGGGCUAUGGGUG	4754	ucAGucGGGGcuAuGGGuGdTsdT	sense

345-364	4755	CACCCAUAGCCCCGACUGA	4756	cACCcAuAGCCCCGACUGAdTsdT	antis

346-365	4757	CAGUCGGGGCUAUGGGUGG	4758	cAGucGGGGcuAuGGGuGGdTsdT	sense

346-365	4759	CCACCCAUAGCCCCGACUG	4760	CcACCcAuAGCCCCGACUGdTsdT	antis

350-369	4761	CGGGGCUAUGGGUGGGGGC	4762	cGGGGcuAuGGGuGGGGGcdTsdT	sense

350-369	4763	GCCCCCACCCAUAGCCCCG	4764	GCCCCcACCcAuAGCCCCGdTsdT	antis

374-393	4765	AGCCUCGAGCUCCGGGGGU	4766	AGccucGAGcuccGGGGGudTsdT	sense

374-393	4767	ACCCCCGGAGCUCGAGGCU	4768	ACCCCCGGAGCUCGAGGCUdTsdT	antis

378-397	4769	UCGAGCUCCGGGGGUGGCC	4770	ucGAGcuccGGGGGuGGccdTsdT	sense

378-397	4771	GGCCACCCCCGGAGCUCGA	4772	GGCcACCCCCGGAGCUCGAdTsdT	antis

379-398	4773	CGAGCUCCGGGGGUGGCCC	4774	cGAGcuccGGGGGuGGcccdTsdT	sense

379-398	4775	GGGCCACCCCCGGAGCUCG	4776	GGGCcACCCCCGGAGCUCGdTsdT	antis

384-403	4777	UCCGGGGGUGGCCCCAGCG	4778	uccGGGGGuGGccccAGcGdTsdT	sense

384-403	4779	CGCUGGGGCCACCCCCGGA	4780	CGCUGGGGCcACCCCCGGAdTsdT	antis

394-413	4781	GCCCCAGCGGCAGCGGCGG	4782	GccccAGcGGcAGcGGcGGdTsdT	sense

394-413	4783	CCGCCGCUGCCGCUGGGGC	4784	CCGCCGCUGCCGCUGGGGCdTsdT	antis

418-437	4785	GCAGCGGUGGCCCCGGCGC	4786	GcAGcGGuGGccccGGcGcdTsdT	sense

418-437	4787	GCGCCGGGGCCACCGCUGC	4788	GCGCCGGGGCcACCGCUGCdTsdT	antis

419-438	4789	CAGCGGUGGCCCCGGCGCG	4790	cAGcGGuGGccccGGcGcGdTsdT	sense

419-438	4791	CGCGCCGGGGCCACCGCUG	4792	CGCGCCGGGGCcACCGCUGdTsdT	antis

421-440	4793	GCGGUGGCCCCGGCGCGGG	4794	GcGGuGGccccGGcGcGGGdTsdT	sense

421-440	4795	CCCGCGCCGGGGCCACCGC	4796	CCCGCGCCGGGGCcACCGCdTsdT	antis

422-441	4797	CGGUGGCCCCGGCGCGGGC	4798	cGGuGGccccGGcGcGGGcdTsdT	sense

422-441	4799	GCCCGCGCCGGGGCCACCG	4800	GCCCGCGCCGGGGCcACCGdTsdT	antis

423-442	4801	GGUGGCCCCGGCGCGGGCA	4802	GGuGGccccGGcGcGGGcAdTsdT	sense

423-442	4803	UGCCCGCGCCGGGGCCACC	4804	UGCCCGCGCCGGGGCcACCdTsdT	antis

424-443	4805	GUGGCCCCGGCGCGGGCAC	4806	GuGGccccGGcGcGGGcAcdTsdT	sense

424-443	4807	GUGCCCGCGCCGGGGCCAC	4808	GUGCCCGCGCCGGGGCcACdTsdT	antis

443-462	4809	UAGCUUCCCGCCGCCGGGA	4810	uAGcuucccGccGccGGGAdTsdT	sense

443-462	4811	UCCCGGCGGCGGGAAGCUA	4812	UCCCGGCGGCGGGAAGCuAdTsdT	antis

450-469	4813	CCGCCGCCGGGAGUGAAGC	4814	ccGccGccGGGAGuGAAGcdTsdT	sense

450-469	4815	GCUUCACUCCCGGCGGCGG	4816	GCUUcACUCCCGGCGGCGGdTsdT	antis

455-474	4817	GCCGGGAGUGAAGCUGGGC	4818	GccGGGAGuGAAGcuGGGcdTsdT	sense

455-474	4819	GCCCAGCUUCACUCCCGGC	4820	GCCcAGCUUcACUCCCGGCdTsdT	antis

457-476	4821	CGGGAGUGAAGCUGGGCCG	4822	cGGGAGuGAAGcuGGGccGdTsdT	sense

457-476	4823	CGGCCCAGCUUCACUCCCG	4824	CGGCCcAGCUUcACUCCCGdTsdT	antis

462-481	4825	GUGAAGCUGGGCCGUGACA	4826	GuGAAGcuGGGccGuGAcAdTsdT	sense

462-481	4827	UGUCACGGCCCAGCUUCAC	4828	UGUcACGGCCcAGCUUcACdTsdT	antis

467-486	4829	GCUGGGCCGUGACAGCGGG	4830	GcuGGGccGuGAcAGcGGGdTsdT	sense

467-486	4831	CCCGCUGUCACGGCCCAGC	4832	CCCGCUGUcACGGCCcAGCdTsdT	antis

478-497	4833	ACAGCGGGAAGGUGACCAC	4834	AcAGcGGGAAGGuGAccAcdTsdT	sense

478-497	4835	GUGGUCACCUUCCCGCUGU	4836	GUGGUcACCUUCCCGCUGUdTsdT	antis

482-501	4837	CGGGAAGGUGACCACAGUG	4838	cGGGAAGGuGAccAcAGuGdTsdT	sense

482-501	4839	CACUGUGGUCACCUUCCCG	4840	cACUGUGGUcACCUUCCCGdTsdT	antis

498-517	4841	GUGGUAGCCACUGUAGGCC	4842	GuGGuAGccAcuGuAGGccdTsdT	sense

498-517	4843	GGCCUACAGUGGCUACCAC	4844	GGCCuAcAGUGGCuACcACdTsdT	antis

499-518	4845	UGGUAGCCACUGUAGGCCA	4846	uGGuAGccAcuGuAGGccAdTsdT	sense

499-518	4847	UGGCCUACAGUGGCUACCA	4848	UGGCCuAcAGUGGCuACcAdTsdT	antis

500-519	4849	GGUAGCCACUGUAGGCCAA	4850	GGuAGccAcuGuAGGccAAdTsdT	sense

500-519	4851	UUGGCCUACAGUGGCUACC	4852	UUGGCCuAcAGUGGCuACCdTsdT	antis

501-520	4853	GUAGCCACUGUAGGCCAAG	4854	GuAGccAcuGuAGGccAAGdTsdT	sense

501-520	4855	CUUGGCCUACAGUGGCUAC	4856	CUUGGCCuAcAGUGGCuACdTsdT	antis

508-527	4857	CUGUAGGCCAAGGCCCAGA	4858	cuGuAGGccAAGGcccAGAdTsdT	sense

508-527	4859	UCUGGGCCUUGGCCUACAG	4860	UCUGGGCCUUGGCCuAcAGdTsdT	antis

514-533	4861	GCCAAGGCCCAGAGCGUUC	4862	GccAAGGcccAGAGcGuucdTsdT	sense

514-533	4863	GAACGCUCUGGGCCUUGGC	4864	GAACGCUCUGGGCCUUGGCdTsdT	antis

515-534	4865	CCAAGGCCCAGAGCGUUCC	4866	ccAAGGcccAGAGcGuuccdTsdT	sense

515-534	4867	GGAACGCUCUGGGCCUUGG	4868	GGAACGCUCUGGGCCUUGGdTsdT	antis

540-559	4869	GUGGCUUACACUGACAUCA	4870	GuGGcuuAcAcuGAcAucAdTsdT	sense

540-559	4871	UGAUGUCAGUGUAAGCCAC	4872	UGAUGUcAGUGuAAGCcACdTsdT	antis

541-560	4873	UGGCUUACACUGACAUCAA	4874	uGGcuuAcAcuGAcAucAAdTsdT	sense

541-560	4875	UUGAUGUCAGUGUAAGCCA	4876	UUGAUGUcAGUGuAAGCcAdTsdT	antis

543-562	4877	GCUUACACUGACAUCAAAG	4878	GcuuAcAcuGAcAucAAAGdTsdT	sense

543-562	4879	CUUUGAUGUCAGUGUAAGC	4880	CUUUGAUGUcAGUGuAAGCdTsdT	antis

546-565	4881	UACACUGACAUCAAAGUGA	4882	uAcAcuGAcAucAAAGuGAdTsdT	sense

546-565	4883	UCACUUUGAUGUCAGUGUA	4884	UcACUUUGAUGUcAGUGuAdTsdT	antis

594-613	4885	CAGGCACGGCUGGCAGAGA	4886	cAGGcAcGGcuGGcAGAGAdTsdT	sense

594-613	4887	UCUCUGCCAGCCGUGCCUG	4888	UCUCUGCcAGCCGUGCCUGdTsdT	antis

605-624	4889	GGCAGAGACGAGGGAACUG	4890	GGcAGAGAcGAGGGAAcuGdTsdT	sense

605-624	4891	CAGUUCCCUCGUCUCUGCC	4892	cAGUUCCCUCGUCUCUGCCdTsdT	antis

607-626	4893	CAGAGACGAGGGAACUGGU	4894	cAGAGAcGAGGGAAcuGGudTsdT	sense

607-626	4895	ACCAGUUCCCUCGUCUCUG	4896	ACcAGUUCCCUCGUCUCUGdTsdT	antis

617-636	4897	GGAACUGGUGGCCAUCAAG	4898	GGAAcuGGuGGccAucAAGdTsdT	sense

617-636	4899	CUUGAUGGCCACCAGUUCC	4900	CUUGAUGGCcACcAGUUCCdTsdT	antis

618-637	4901	GAACUGGUGGCCAUCAAGA	4902	GAAcuGGuGGccAucAAGAdTsdT	sense

618-637	4903	UCUUGAUGGCCACCAGUUC	4904	UCUUGAUGGCcACcAGUUCdTsdT	antis

619-638	4905	AACUGGUGGCCAUCAAGAA	4906	AAcuGGuGGccAucAAGAAdTsdT	sense

619-638	4907	UUCUUGAUGGCCACCAGUU	4908	UUCUUGAUGGCcACcAGUUdTsdT	antis

624-643	4909	GUGGCCAUCAAGAAGGUUC	4910	GuGGccAucAAGAAGGuucdTsdT	sense

624-643	4911	GAACCUUCUUGAUGGCCAC	4912	GAACCUUCUUGAUGGCcACdTsdT	antis

625-644	4913	UGGCCAUCAAGAAGGUUCU	4914	uGGccAucAAGAAGGuucudTsdT	sense

625-644	4915	AGAACCUUCUUGAUGGCCA	4916	AGAACCUUCUUGAUGGCcAdTsdT	antis

647-666	4917	GGACAAAAGGUUCAAGAAC	4918	GGAcAAAAGGuucAAGAAcdTsdT	sense

647-666	4919	GUUCUUGAACCUUUUGUCC	4920	GUUCUUGAACCUUUUGUCCdTsdT	antis

648-667	4921	GACAAAAGGUUCAAGAACC	4922	GAcAAAAGGuucAAGAAccdTsdT	sense

648-667	4923	GGUUCUUGAACCUUUUGUC	4924	GGUUCUUGAACCUUUUGUCdTsdT	antis

666-685	4925	CGAGAACUGCAGAUUAUGC	4926	cGAGAAcuGcAGAuuAuGcdTsdT	sense

666-685	4927	GCAUAAUCUGCAGUUCUCG	4928	GcAuAAUCUGcAGUUCUCGdTsdT	antis

713-732	4929	GCUGCGGUACUUUUUCUAC	4930	GcuGcGGuAcuuuuucuAcdTsdT	sense

713-732	4931	GUAGAAAAAGUACCGCAGC	4932	GuAGAAAAAGuACCGcAGCdTsdT	antis

717-736	4933	CGGUACUUUUUCUACUCCA	4934	cGGuAcuuuuucuAcuccAdTsdT	sense

717-736	4935	UGGAGUAGAAAAAGUACCG	4936	UGGAGuAGAAAAAGuACCGdTsdT	antis

739-758	4937	GGGAGAAGAAGGACGAGCU	4938	GGGAGAAGAAGGAcGAGcudTsdT	sense

739-758	4939	AGCUCGUCCUUCUUCUCCC	4940	AGCUCGUCCUUCUUCUCCCdTsdT	antis

740-759	4941	GGAGAAGAAGGACGAGCUG	4942	GGAGAAGAAGGAcGAGcuGdTsdT	sense

740-759	4943	CAGCUCGUCCUUCUUCUCC	4944	cAGCUCGUCCUUCUUCUCCdTsdT	antis

794-813	4945	GGUGUACCGAGUGGCCCGC	4946	GGuGuAccGAGuGGcccGcdTsdT	sense

794-813	4947	GCGGGCCACUCGGUACACC	4948	GCGGGCcACUCGGuAcACCdTsdT	antis

798-817	4949	UACCGAGUGGCCCGCCACU	4950	uAccGAGuGGcccGccAcudTsdT	sense

798-817	4951	AGUGGCGGGCCACUCGGUA	4952	AGUGGCGGGCcACUCGGuAdTsdT	antis

822-841	4953	AAGGCCAAGCUGAUCACCC	4954	AAGGccAAGcuGAucAcccdTsdT	sense

822-841	4955	GGGUGAUCAGCUUGGCCUU	4956	GGGUGAUcAGCUUGGCCUUdTsdT	antis

823-842	4957	AGGCCAAGCUGAUCACCCC	4958	AGGccAAGcuGAucAccccdTsdT	sense

823-842	4959	GGGGUGAUCAGCUUGGCCU	4960	GGGGUGAUcAGCUUGGCCUdTsdT	antis

846-865	4961	AUCUACAUCAAGGUGUACA	4962	AucuAcAucAAGGuGuAcAdTsdT	sense

846-865	4963	UGUACACCUUGAUGUAGAU	4964	UGuAcACCUUGAUGuAGAUdTsdT	antis

847-866	4965	UCUACAUCAAGGUGUACAU	4966	ucuAcAucAAGGuGuAcAudTsdT	sense

847-866	4967	AUGUACACCUUGAUGUAGA	4968	AUGuAcACCUUGAUGuAGAdTsdT	antis

848-867	4969	CUACAUCAAGGUGUACAUG	4970	cuAcAucAAGGuGuAcAuGdTsdT	sense

848-867	4971	CAUGUACACCUUGAUGUAG	4972	cAUGuAcACCUUGAUGuAGdTsdT	antis

849-868	4973	UACAUCAAGGUGUACAUGU	4974	uAcAucAAGGuGuAcAuGudTsdT	sense

849-868	4975	ACAUGUACACCUUGAUGUA	4976	AcAUGuAcACCUUGAUGuAdTsdT	antis

889-908	4977	CCUACAUCCACUCCCAAGG	4978	ccuAcAuccAcucccAAGGdTsdT	sense

889-908	4979	CCUUGGGAGUGGAUGUAGG	4980	CCUUGGGAGUGGAUGuAGGdTsdT	antis

892-911	4981	ACAUCCACUCCCAAGGUGU	4982	AcAuccAcucccAAGGuGudTsdT	sense

892-911	4983	ACACCUUGGGAGUGGAUGU	4984	AcACCUUGGGAGUGGAUGUdTsdT	antis

893-912	4985	CAUCCACUCCCAAGGUGUG	4986	cAuccAcucccAAGGuGuGdTsdT	sense

893-912	4987	CACACCUUGGGAGUGGAUG	4988	cAcACCUUGGGAGUGGAUGdTsdT	antis

904-923	4989	AAGGUGUGUGUCACCGUGA	4990	AAGGuGuGuGucAccGuGAdTsdT	sense

904-923	4991	UCACGGUGACACACACCUU	4992	UcACGGUGAcAcAcACCUUdTsdT	antis

905-924	4993	AGGUGUGUGUCACCGUGAC	4994	AGGuGuGuGucAccGuGAcdTsdT	sense

905-924	4995	GUCACGGUGACACACACCU	4996	GUcACGGUGAcAcAcACCUdTsdT	antis

906-925	4997	GGUGUGUGUCACCGUGACA	4998	GGuGuGuGucAccGuGAcAdTsdT	sense

906-925	4999	UGUCACGGUGACACACACC	5000	UGUcACGGUGAcAcAcACCdTsdT	antis

907-926	5001	GUGUGUGUCACCGUGACAU	5002	GuGuGuGucAccGuGAcAudTsdT	sense

907-926	5003	AUGUCACGGUGACACACAC	5004	AUGUcACGGUGAcAcAcACdTsdT	antis

908-927	5005	UGUGUGUCACCGUGACAUC	5006	uGuGuGucAccGuGAcAucdTsdT	sense

908-927	5007	GAUGUCACGGUGACACACA	5008	GAUGUcACGGUGAcAcAcAdTsdT	antis

909-928	5009	GUGUGUCACCGUGACAUCA	5010	GuGuGucAccGuGAcAucAdTsdT	sense

909-928	5011	UGAUGUCACGGUGACACAC	5012	UGAUGUcACGGUGAcAcACdTsdT	antis

910-929	5013	UGUGUCACCGUGACAUCAA	5014	uGuGucAccGuGAcAucAAdTsdT	sense

910-929	5015	UUGAUGUCACGGUGACACA	5016	UUGAUGUcACGGUGAcAcAdTsdT	antis

919-938	5017	GUGACAUCAAGCCCCAGAA	5018	GuGAcAucAAGccccAGAAdTsdT	sense

919-938	5019	UUCUGGGGCUUGAUGUCAC	5020	UUCUGGGGCUUGAUGUcACdTsdT	antis

946-965	5021	UGGACCCUGACACUGCUGU	5022	uGGAcccuGAcAcuGcuGudTsdT	sense

946-965	5023	ACAGCAGUGUCAGGGUCCA	5024	AcAGcAGUGUcAGGGUCcAdTsdT	antis

950-969	5025	CCCUGACACUGCUGUCCUC	5026	cccuGAcAcuGcuGuccucdTsdT	sense

950-969	5027	GAGGACAGCAGUGUCAGGG	5028	GAGGAcAGcAGUGUcAGGGdTsdT	antis

957-976	5029	ACUGCUGUCCUCAAGCUCU	5030	AcuGcuGuccucAAGcucudTsdT	sense

957-976	5031	AGAGCUUGAGGACAGCAGU	5032	AGAGCUUGAGGAcAGcAGUdTsdT	antis

961-980	5033	CUGUCCUCAAGCUCUGCGA	5034	cuGuccucAAGcucuGcGAdTsdT	sense

961-980	5035	UCGCAGAGCUUGAGGACAG	5036	UCGcAGAGCUUGAGGAcAGdTsdT	antis

962-981	5037	UGUCCUCAAGCUCUGCGAU	5038	uGuccucAAGcucuGcGAudTsdT	sense

962-981	5039	AUCGCAGAGCUUGAGGACA	5040	AUCGcAGAGCUUGAGGAcAdTsdT	antis

1020-1039	5041	GUGUCCUACAUCUGCUCUC	5042	GuGuccuAcAucuGcucucdTsdT	sense

1020-1039	5043	GAGAGCAGAUGUAGGACAC	5044	GAGAGcAGAUGuAGGAcACdTsdT	antis

1029-1048	5045	AUCUGCUCUCGGUACUACC	5046	AucuGcucucGGuAcuAccdTsdT	sense

1029-1048	5047	GGUAGUACCGAGAGCAGAU	5048	GGuAGuACCGAGAGcAGAUdTsdT	antis

1048-1067	5049	GUGCUCCAGAACUCAUCUU	5050	GuGcuccAGAAcucAucuudTsdT	sense

1048-1067	5051	AAGAUGAGUUCUGGAGCAC	5052	AAGAUGAGUUCUGGAGcACdTsdT	antis

1049-1068	5053	UGCUCCAGAACUCAUCUUU	5054	uGcuccAGAAcucAucuuudTsdT	sense

1049-1068	5055	AAAGAUGAGUUCUGGAGCA	5056	AAAGAUGAGUUCUGGAGcAdTsdT	antis

1050-1069	5057	GCUCCAGAACUCAUCUUUG	5058	GcuccAGAAcucAucuuuGdTsdT	sense

1050-1069	5059	CAAAGAUGAGUUCUGGAGC	5060	cAAAGAUGAGUUCUGGAGCdTsdT	antis

1059-1078	5061	CUCAUCUUUGGAGCCACAG	5062	cucAucuuuGGAGccAcAGdTsdT	sense

1059-1078	5063	CUGUGGCUCCAAAGAUGAG	5064	CUGUGGCUCcAAAGAUGAGdTsdT	antis

1087-1106	5065	CGUCCAUCGAUGUGUGGUC	5066	cGuccAucGAuGuGuGGucdTsdT	sense

1087-1106	5067	GACCACACAUCGAUGGACG	5068	GACcAcAcAUCGAUGGACGdTsdT	antis

1096-1115	5069	AUGUGUGGUCGGCUGGCUG	5070	AuGuGuGGucGGcuGGcuGdTsdT	sense

1096-1115	5071	CAGCCAGCCGACCACACAU	5072	cAGCcAGCCGACcAcAcAUdTsdT	antis

1130-1149	5073	ACUUCUCGGCCAGCCCAUC	5074	AcuucucGGccAGcccAucdTsdT	sense

1130-1149	5075	GAUGGGCUGGCCGAGAAGU	5076	GAUGGGCUGGCCGAGAAGUdTsdT	antis

1134-1153	5077	CUCGGCCAGCCCAUCUUCC	5078	cucGGccAGcccAucuuccdTsdT	sense

1134-1153	5079	GGAAGAUGGGCUGGCCGAG	5080	GGAAGAUGGGCUGGCCGAGdTsdT	antis

1141-1160	5081	AGCCCAUCUUCCCUGGGGA	5082	AGcccAucuucccuGGGGAdTsdT	sense

1141-1160	5083	UCCCCAGGGAAGAUGGGCU	5084	UCCCcAGGGAAGAUGGGCUdTsdT	antis

1144-1163	5085	CCAUCUUCCCUGGGGACAG	5086	ccAucuucccuGGGGAcAGdTsdT	sense

1144-1163	5087	CUGUCCCCAGGGAAGAUGG	5088	CUGUCCCcAGGGAAGAUGGdTsdT	antis

1151-1170	5089	CCCUGGGGACAGUGGGGUG	5090	cccuGGGGAcAGuGGGGuGdTsdT	sense

1151-1170	5091	CACCCCACUGUCCCCAGGG	5092	cACCCcACUGUCCCcAGGGdTsdT	antis

1156-1175	5093	GGGACAGUGGGGUGGACCA	5094	GGGAcAGuGGGGuGGAccAdTsdT	sense

1156-1175	5095	UGGUCCACCCCACUGUCCC	5096	UGGUCcACCCcACUGUCCCdTsdT	antis

1157-1176	5097	GGACAGUGGGGUGGACCAG	5098	GGAcAGuGGGGuGGAccAGdTsdT	sense

1157-1176	5099	CUGGUCCACCCCACUGUCC	5100	CUGGUCcACCCcACUGUCCdTsdT	antis

1158-1177	5101	GACAGUGGGGUGGACCAGC	5102	GAcAGuGGGGuGGAccAGcdTsdT	sense

1158-1177	5103	GCUGGUCCACCCCACUGUC	5104	GCUGGUCcACCCcACUGUCdTsdT	antis

1159-1178	5105	ACAGUGGGGUGGACCAGCU	5106	AcAGuGGGGuGGAccAGcudTsdT	sense

1159-1178	5107	AGCUGGUCCACCCCACUGU	5108	AGCUGGUCcACCCcACUGUdTsdT	antis

1160-1179	5109	CAGUGGGGUGGACCAGCUU	5110	cAGuGGGGuGGAccAGcuudTsdT	sense

1160-1179	5111	AAGCUGGUCCACCCCACUG	5112	AAGCUGGUCcACCCcACUGdTsdT	antis

1244-1263	5113	UACGGAGUUCAAGUUCCCC	5114	uAcGGAGuucAAGuuccccdTsdT	sense

1244-1263	5115	GGGGAACUUGAACUCCGUA	5116	GGGGAACUUGAACUCCGuAdTsdT	antis

1246-1265	5117	CGGAGUUCAAGUUCCCCCA	5118	cGGAGuucAAGuucccccAdTsdT	sense

1246-1265	5119	UGGGGGAACUUGAACUCCG	5120	UGGGGGAACUUGAACUCCGdTsdT	antis

1273-1292	5121	CUCACCCUUGGACAAAGGU	5122	cucAcccuuGGAcAAAGGudTsdT	sense

1273-1292	5123	ACCUUUGUCCAAGGGUGAG	5124	ACCUUUGUCcAAGGGUGAGdTsdT	antis

1275-1294	5125	CACCCUUGGACAAAGGUGU	5126	cAcccuuGGAcAAAGGuGudTsdT	sense

1275-1294	5127	ACACCUUUGUCCAAGGGUG	5128	AcACCUUUGUCcAAGGGUGdTsdT	antis

1278-1297	5129	CCUUGGACAAAGGUGUUCA	5130	ccuuGGAcAAAGGuGuucAdTsdT	sense

1278-1297	5131	UGAACACCUUUGUCCAAGG	5132	UGAAcACCUUUGUCcAAGGdTsdT	antis

1279-1298	5133	CUUGGACAAAGGUGUUCAA	5134	cuuGGAcAAAGGuGuucAAdTsdT	sense

1279-1298	5135	UUGAACACCUUUGUCCAAG	5136	UUGAAcACCUUUGUCcAAGdTsdT	antis

1288-1307	5137	AGGUGUUCAAAUCUUCAAA	5138	AGGuGuucAAAucuucAAAdTsdT	sense

1288-1307	5139	UUUGAAGAUUUGAACACCU	5140	UUUGAAGAUUUGAAcACCUdTsdT	antis

1291-1310	5141	UGUUCAAAUCUUCAAAGAC	5142	uGuucAAAucuucAAAGAcdTsdT	sense

1291-1310	5143	GUCUUUGAAGAUUUGAACA	5144	GUCUUUGAAGAUUUGAAcAdTsdT	antis

1292-1311	5145	GUUCAAAUCUUCAAAGACA	5146	GuucAAAucuucAAAGAcAdTsdT	sense

1292-1311	5147	UGUCUUUGAAGAUUUGAAC	5148	UGUCUUUGAAGAUUUGAACdTsdT	antis

1293-1312	5149	UUCAAAUCUUCAAAGACAC	5150	uucAAAucuucAAAGAcAcdTsdT	sense

1293-1312	5151	GUGUCUUUGAAGAUUUGAA	5152	GUGUCUUUGAAGAUUUGAAdTsdT	antis

1294-1313	5153	UCAAAUCUUCAAAGACACC	5154	ucAAAucuucAAAGAcAccdTsdT	sense

1294-1313	5155	GGUGUCUUUGAAGAUUUGA	5156	GGUGUCUUUGAAGAUUUGAdTsdT	antis

1314-1333	5157	CCUGAGGCCAUUGCACUCU	5158	ccuGAGGccAuuGcAcucudTsdT	sense

1314-1333	5159	AGAGUGCAAUGGCCUCAGG	5160	AGAGUGcAAUGGCCUcAGGdTsdT	antis

1320-1339	5161	GCCAUUGCACUCUGCUCUA	5162	GccAuuGcAcucuGcucuAdTsdT	sense

1320-1339	5163	UAGAGCAGAGUGCAAUGGC	5164	uAGAGcAGAGUGcAAUGGCdTsdT	antis

1336-1355	5165	CUAGCCUACUGGAGUACAC	5166	cuAGccuAcuGGAGuAcAcdTsdT	sense

1336-1355	5167	GUGUACUCCAGUAGGCUAG	5168	GUGuACUCcAGuAGGCuAGdTsdT	antis

1353-1372	5169	ACGCCAUCCUCAAGGCUCU	5170	AcGccAuccucAAGGcucudTsdT	sense

1353-1372	5171	AGAGCCUUGAGGAUGGCGU	5172	AGAGCCUUGAGGAUGGCGUdTsdT	antis

1355-1374	5173	GCCAUCCUCAAGGCUCUCC	5174	GccAuccucAAGGcucuccdTsdT	sense

1355-1374	5175	GGAGAGCCUUGAGGAUGGC	5176	GGAGAGCCUUGAGGAUGGCdTsdT	antis

1359-1378	5177	UCCUCAAGGCUCUCCCCAC	5178	uccucAAGGcucuccccAcdTsdT	sense

1359-1378	5179	GUGGGGAGAGCCUUGAGGA	5180	GUGGGGAGAGCCUUGAGGAdTsdT	antis

1372-1391	5181	CCCCACUCGAGGCUUGUGC	5182	ccccAcucGAGGcuuGuGcdTsdT	sense

1372-1391	5183	GCACAAGCCUCGAGUGGGG	5184	GcAcAAGCCUCGAGUGGGGdTsdT	antis

1373-1392	5185	CCCACUCGAGGCUUGUGCC	5186	cccAcucGAGGcuuGuGccdTsdT	sense

1373-1392	5187	GGCACAAGCCUCGAGUGGG	5188	GGcAcAAGCCUCGAGUGGGdTsdT	antis

1374-1393	5189	CCACUCGAGGCUUGUGCCC	5190	ccAcucGAGGcuuGuGcccdTsdT	sense

1374-1393	5191	GGGCACAAGCCUCGAGUGG	5192	GGGcAcAAGCCUCGAGUGGdTsdT	antis

1376-1395	5193	ACUCGAGGCUUGUGCCCAC	5194	AcucGAGGcuuGuGcccAcdTsdT	sense

1376-1395	5195	GUGGGCACAAGCCUCGAGU	5196	GUGGGcAcAAGCCUCGAGUdTsdT	antis

1377-1396	5197	CUCGAGGCUUGUGCCCACA	5198	cucGAGGcuuGuGcccAcAdTsdT	sense

1377-1396	5199	UGUGGGCACAAGCCUCGAG	5200	UGUGGGcAcAAGCCUCGAGdTsdT	antis

1378-1397	5201	UCGAGGCUUGUGCCCACAG	5202	ucGAGGcuuGuGcccAcAGdTsdT	sense

1378-1397	5203	CUGUGGGCACAAGCCUCGA	5204	CUGUGGGcAcAAGCCUCGAdTsdT	antis

1389-1408	5205	GCCCACAGCUUCUUCGAUG	5206	GcccAcAGcuucuucGAuGdTsdT	sense

1389-1408	5207	CAUCGAAGAAGCUGUGGGC	5208	cAUCGAAGAAGCUGUGGGCdTsdT	antis

1391-1410	5209	CCACAGCUUCUUCGAUGAA	5210	ccAcAGcuucuucGAuGAAdTsdT	sense

1391-1410	5211	UUCAUCGAAGAAGCUGUGG	5212	UUcAUCGAAGAAGCUGUGGdTsdT	antis

1423-1442	5213	GAGCCCAGCUCCCCAACGA	5214	GAGcccAGcuccccAAcGAdTsdT	sense

1423-1442	5215	UCGUUGGGGAGCUGGGCUC	5216	UCGUUGGGGAGCUGGGCUCdTsdT	antis

1469-1488	5217	CAGUCCUGGUGAACUGUCC	5218	cAGuccuGGuGAAcuGuccdTsdT	sense

1469-1488	5219	GGACAGUUCACCAGGACUG	5220	GGAcAGUUcACcAGGACUGdTsdT	antis

1484-1503	5221	GUCCAUCCAACCAUCUCUC	5222	GuccAuccAAccAucucucdTsdT	sense

1484-1503	5223	GAGAGAUGGUUGGAUGGAC	5224	GAGAGAUGGUUGGAUGGACdTsdT	antis

1496-1515	5225	AUCUCUCAAUGCCAUUCUC	5226	AucucucAAuGccAuucucdTsdT	sense

1496-1515	5227	GAGAAUGGCAUUGAGAGAU	5228	GAGAAUGGcAUUGAGAGAUdTsdT	antis

1498-1517	5229	CUCUCAAUGCCAUUCUCAU	5230	cucucAAuGccAuucucAudTsdT	sense

1498-1517	5231	AUGAGAAUGGCAUUGAGAG	5232	AUGAGAAUGGcAUUGAGAGdTsdT	antis

1499-1518	5233	UCUCAAUGCCAUUCUCAUC	5234	ucucAAuGccAuucucAucdTsdT	sense

1499-1518	5235	GAUGAGAAUGGCAUUGAGA	5236	GAUGAGAAUGGcAUUGAGAdTsdT	antis

1502-1521	5237	CAAUGCCAUUCUCAUCCCU	5238	cAAuGccAuucucAucccudTsdT	sense

1502-1521	5239	AGGGAUGAGAAUGGCAUUG	5240	AGGGAUGAGAAUGGcAUUGdTsdT	antis

1541-1560	5241	AGGCCCUGCUUCUCCCCUC	5242	AGGcccuGcuucuccccucdTsdT	sense

1541-1560	5243	GAGGGGAGAAGCAGGGCCU	5244	GAGGGGAGAAGcAGGGCCUdTsdT	antis

1542-1561	5245	GGCCCUGCUUCUCCCCUCA	5246	GGcccuGcuucuccccucAdTsdT	sense

1542-1561	5247	UGAGGGGAGAAGCAGGGCC	5248	UGAGGGGAGAAGcAGGGCCdTsdT	antis

1548-1567	5249	GCUUCUCCCCUCACCACUU	5250	GcuucuccccucAccAcuudTsdT	sense

1548-1567	5251	AAGUGGUGAGGGGAGAAGC	5252	AAGUGGUGAGGGGAGAAGCdTsdT	antis

1549-1568	5253	CUUCUCCCCUCACCACUUC	5254	cuucuccccucAccAcuucdTsdT	sense

1549-1568	5255	GAAGUGGUGAGGGGAGAAG	5256	GAAGUGGUGAGGGGAGAAGdTsdT	antis

1552-1571	5257	CUCCCCUCACCACUUCCUA	5258	cuccccucAccAcuuccuAdTsdT	sense

1552-1571	5259	UAGGAAGUGGUGAGGGGAG	5260	uAGGAAGUGGUGAGGGGAGdTsdT	antis

1557-1576	5261	CUCACCACUUCCUACAACC	5262	cucAccAcuuccuAcAAccdTsdT	sense

1557-1576	5263	GGUUGUAGGAAGUGGUGAG	5264	GGUUGuAGGAAGUGGUGAGdTsdT	antis

1575-1594	5265	CCAUCCUCACAAGCUUUAA	5266	ccAuccucAcAAGcuuuAAdTsdT	sense

1575-1594	5267	UUAAAGCUUGUGAGGAUGG	5268	UuAAAGCUUGUGAGGAUGGdTsdT	antis

1600-1619	5269	CUCAGACUGGCCAAGAUUG	5270	cucAGAcuGGccAAGAuuGdTsdT	sense

1600-1619	5271	CAAUCUUGGCCAGUCUGAG	5272	cAAUCUUGGCcAGUCUGAGdTsdT	antis

1616-1635	5273	UUGGCAGCCAUCUGAUGCC	5274	uuGGcAGccAucuGAuGccdTsdT	sense

1616-1635	5275	GGCAUCAGAUGGCUGCCAA	5276	GGcAUcAGAUGGCUGCcAAdTsdT	antis

1617-1636	5277	UGGCAGCCAUCUGAUGCCA	5278	uGGcAGccAucuGAuGccAdTsdT	sense

1617-1636	5279	UGGCAUCAGAUGGCUGCCA	5280	UGGcAUcAGAUGGCUGCcAdTsdT	antis

1618-1637	5281	GGCAGCCAUCUGAUGCCAC	5282	GGcAGccAucuGAuGccAcdTsdT	sense

1618-1637	5283	GUGGCAUCAGAUGGCUGCC	5284	GUGGcAUcAGAUGGCUGCCdTsdT	antis

1619-1638	5285	GCAGCCAUCUGAUGCCACA	5286	GcAGccAucuGAuGccAcAdTsdT	sense

1619-1638	5287	UGUGGCAUCAGAUGGCUGC	5288	UGUGGcAUcAGAUGGCUGCdTsdT	antis

1622-1641	5289	GCCAUCUGAUGCCACAACU	5290	GccAucuGAuGccAcAAcudTsdT	sense

1622-1641	5291	AGUUGUGGCAUCAGAUGGC	5292	AGUUGUGGcAUcAGAUGGCdTsdT	antis

1647-1666	5293	CUCGCUAGCUCUUCCUGAG	5294	cucGcuAGcucuuccuGAGdTsdT	sense

1647-1666	5295	CUCAGGAAGAGCUAGCGAG	5296	CUcAGGAAGAGCuAGCGAGdTsdT	antis

1648-1667	5297	UCGCUAGCUCUUCCUGAGG	5298	ucGcuAGcucuuccuGAGGdTsdT	sense

1648-1667	5299	CCUCAGGAAGAGCUAGCGA	5300	CCUcAGGAAGAGCuAGCGAdTsdT	antis

1649-1668	5301	CGCUAGCUCUUCCUGAGGG	5302	cGcuAGcucuuccuGAGGGdTsdT	sense

1649-1668	5303	CCCUCAGGAAGAGCUAGCG	5304	CCCUcAGGAAGAGCuAGCGdTsdT	antis

1658-1677	5305	UUCCUGAGGGCCCCACCGA	5306	uuccuGAGGGccccAccGAdTsdT	sense

1658-1677	5307	UCGGUGGGGCCCUCAGGAA	5308	UCGGUGGGGCCCUcAGGAAdTsdT	antis

1661-1680	5309	CUGAGGGCCCCACCGACUA	5310	cuGAGGGccccAccGAcuAdTsdT	sense

1661-1680	5311	UAGUCGGUGGGGCCCUCAG	5312	uAGUCGGUGGGGCCCUcAGdTsdT	antis

1662-1681	5313	UGAGGGCCCCACCGACUAC	5314	uGAGGGccccAccGAcuAcdTsdT	sense

1662-1681	5315	GUAGUCGGUGGGGCCCUCA	5316	GuAGUCGGUGGGGCCCUcAdTsdT	antis

1663-1682	5317	GAGGGCCCCACCGACUACC	5318	GAGGGccccAccGAcuAccdTsdT	sense

1663-1682	5319	GGUAGUCGGUGGGGCCCUC	5320	GGuAGUCGGUGGGGCCCUCdTsdT	antis

1800-1819	5321	AUCUAGGCCUCCCUCAGCA	5322	AucuAGGccucccucAGcAdTsdT	sense

1800-1819	5323	UGCUGAGGGAGGCCUAGAU	5324	UGCUGAGGGAGGCCuAGAUdTsdT	antis

1807-1826	5325	CCUCCCUCAGCAGCCUAAC	5326	ccucccucAGcAGccuAAcdTsdT	sense

1807-1826	5327	GUUAGGCUGCUGAGGGAGG	5328	GUuAGGCUGCUGAGGGAGGdTsdT	antis

1819-1838	5329	GCCUAACCUCUGUGGUGGG	5330	GccuAAccucuGuGGuGGGdTsdT	sense

1819-1838	5331	CCCACCACAGAGGUUAGGC	5332	CCcACcAcAGAGGUuAGGCdTsdT	antis

1856-1875	5333	AACUGUUUGUAGGGGAGGG	5334	AAcuGuuuGuAGGGGAGGGdTsdT	sense

1856-1875	5335	CCCUCCCCUACAAACAGUU	5336	CCCUCCCCuAcAAAcAGUUdTsdT	antis

1860-1879	5337	GUUUGUAGGGGAGGGGAGA	5338	GuuuGuAGGGGAGGGGAGAdTsdT	sense

1860-1879	5339	UCUCCCCUCCCCUACAAAC	5340	UCUCCCCUCCCCuAcAAACdTsdT	antis

1864-1883	5341	GUAGGGGAGGGGAGAAAAG	5342	GuAGGGGAGGGGAGAAAAGdTsdT	sense

1864-1883	5343	CUUUUCUCCCCUCCCCUAC	5344	CUUUUCUCCCCUCCCCuACdTsdT	antis

1879-1898	5345	AAAGGAAGGACGGGGUUUG	5346	AAAGGAAGGAcGGGGuuuGdTsdT	sense

1879-1898	5347	CAAACCCCGUCCUUCCUUU	5348	cAAACCCCGUCCUUCCUUUdTsdT	antis

1880-1899	5349	AAGGAAGGACGGGGUUUGG	5350	AAGGAAGGAcGGGGuuuGGdTsdT	sense

1880-1899	5351	CCAAACCCCGUCCUUCCUU	5352	CcAAACCCCGUCCUUCCUUdTsdT	antis

1881-1900	5353	AGGAAGGACGGGGUUUGGG	5354	AGGAAGGAcGGGGuuuGGGdTsdT	sense

1881-1900	5355	CCCAAACCCCGUCCUUCCU	5356	CCcAAACCCCGUCCUUCCUdTsdT	antis

1906-1925	5357	AGGACCUUCUACCCCCUUG	5358	AGGAccuucuAcccccuuGdTsdT	sense

1906-1925	5359	CAAGGGGGUAGAAGGUCCU	5360	cAAGGGGGuAGAAGGUCCUdTsdT	antis

1907-1926	5361	GGACCUUCUACCCCCUUGG	5362	GGAccuucuAcccccuuGGdTsdT	sense

1907-1926	5363	CCAAGGGGGUAGAAGGUCC	5364	CcAAGGGGGuAGAAGGUCCdTsdT	antis

1908-1927	5365	GACCUUCUACCCCCUUGGU	5366	GAccuucuAcccccuuGGudTsdT	sense

1908-1927	5367	ACCAAGGGGGUAGAAGGUC	5368	ACcAAGGGGGuAGAAGGUCdTsdT	antis

1909-1928	5369	ACCUUCUACCCCCUUGGUC	5370	AccuucuAcccccuuGGucdTsdT	sense

1909-1928	5371	GACCAAGGGGGUAGAAGGU	5372	GACcAAGGGGGuAGAAGGUdTsdT	antis

1910-1929	5373	CCUUCUACCCCCUUGGUCC	5374	ccuucuAcccccuuGGuccdTsdT	sense

1910-1929	5375	GGACCAAGGGGGUAGAAGG	5376	GGACcAAGGGGGuAGAAGGdTsdT	antis

1911-1930	5377	CUUCUACCCCCUUGGUCCC	5378	cuucuAcccccuuGGucccdTsdT	sense

1911-1930	5379	GGGACCAAGGGGGUAGAAG	5380	GGGACcAAGGGGGuAGAAGdTsdT	antis

1932-1951	5381	CCCCUCCCCCAGGCUACCA	5382	ccccucccccAGGcuAccAdTsdT	sense

1932-1951	5383	UGGUAGCCUGGGGGAGGGG	5384	UGGuAGCCUGGGGGAGGGGdTsdT	antis

1942-1961	5385	AGGCUACCACUCCUUCCCU	5386	AGGcuAccAcuccuucccudTsdT	sense

1942-1961	5387	AGGGAAGGAGUGGUAGCCU	5388	AGGGAAGGAGUGGuAGCCUdTsdT	antis

1943-1962	5389	GGCUACCACUCCUUCCCUC	5390	GGcuAccAcuccuucccucdTsdT	sense

1943-1962	5391	GAGGGAAGGAGUGGUAGCC	5392	GAGGGAAGGAGUGGuAGCCdTsdT	antis

1958-1977	5393	CCUCCCCCCCUCUCCCAGG	5394	ccucccccccucucccAGGdTsdT	sense

1958-1977	5395	CCUGGGAGAGGGGGGGAGG	5396	CCUGGGAGAGGGGGGGAGGdTsdT	antis

1961-1980	5397	CCCCCCCUCUCCCAGGUCC	5398	cccccccucucccAGGuccdTsdT	sense

1961-1980	5399	GGACCUGGGAGAGGGGGGG	5400	GGACCUGGGAGAGGGGGGGdTsdT	antis

1966-1985	5401	CCUCUCCCAGGUCCCUUGU	5402	ccucucccAGGucccuuGudTsdT	sense

1966-1985	5403	ACAAGGGACCUGGGAGAGG	5404	AcAAGGGACCUGGGAGAGGdTsdT	antis

1972-1991	5405	CCAGGUCCCUUGUAAAUAG	5406	ccAGGucccuuGuAAAuAGdTsdT	sense

1972-1991	5407	CUAUUUACAAGGGACCUGG	5408	CuAUUuAcAAGGGACCUGGdTsdT	antis

1989-2008	5409	AGAACCAGCCCAGCCCAUC	5410	AGAAccAGcccAGcccAucdTsdT	sense

1989-2008	5411	GAUGGGCUGGGCUGGUUCU	5412	GAUGGGCUGGGCUGGUUCUdTsdT	antis

1990-2009	5413	GAACCAGCCCAGCCCAUCU	5414	GAAccAGcccAGcccAucudTsdT	sense

1990-2009	5415	AGAUGGGCUGGGCUGGUUC	5416	AGAUGGGCUGGGCUGGUUCdTsdT	antis

1991-2010	5417	AACCAGCCCAGCCCAUCUC	5418	AAccAGcccAGcccAucucdTsdT	sense

1991-2010	5419	GAGAUGGGCUGGGCUGGUU	5420	GAGAUGGGCUGGGCUGGUUdTsdT	antis

1992-2011	5421	ACCAGCCCAGCCCAUCUCU	5422	AccAGcccAGcccAucucudTsdT	sense

1992-2011	5423	AGAGAUGGGCUGGGCUGGU	5424	AGAGAUGGGCUGGGCUGGUdTsdT	antis

1993-2012	5425	CCAGCCCAGCCCAUCUCUC	5426	ccAGcccAGcccAucucucdTsdT	sense

1993-2012	5427	GAGAGAUGGGCUGGGCUGG	5428	GAGAGAUGGGCUGGGCUGGdTsdT	antis

2007-2026	5429	CUCUCGUCUUCCCUUCCCU	5430	cucucGucuucccuucccudTsdT	sense

2007-2026	5431	AGGGAAGGGAAGACGAGAG	5432	AGGGAAGGGAAGACGAGAGdTsdT	antis

2008-2027	5433	UCUCGUCUUCCCUUCCCUG	5434	ucucGucuucccuucccuGdTsdT	sense

2008-2027	5435	CAGGGAAGGGAAGACGAGA	5436	cAGGGAAGGGAAGACGAGAdTsdT	antis

2013-2032	5437	UCUUCCCUUCCCUGGCCCC	5438	ucuucccuucccuGGccccdTsdT	sense

2013-2032	5439	GGGGCCAGGGAAGGGAAGA	5440	GGGGCcAGGGAAGGGAAGAdTsdT	antis

2014-2033	5441	CUUCCCUUCCCUGGCCCCC	5442	cuucccuucccuGGcccccdTsdT	sense

2014-2033	5443	GGGGGCCAGGGAAGGGAAG	5444	GGGGGCcAGGGAAGGGAAGdTsdT	antis

2021-2040	5445	UCCCUGGCCCCCUGGGUGU	5446	ucccuGGcccccuGGGuGudTsdT	sense

2021-2040	5447	ACACCCAGGGGGCCAGGGA	5448	AcACCcAGGGGGCcAGGGAdTsdT	antis

2038-2057	5449	GUAAAUAGAUUGUUAUAAU	5450	GuAAAuAGAuuGuuAuAAudTsdT	sense

2038-2057	5451	AUUAUAACAAUCUAUUUAC	5452	AUuAuAAcAAUCuAUUuACdTsdT	antis

2048-2067	5453	UGUUAUAAUUUUUUCUUAA	5454	uGuuAuAAuuuuuucuuAAdTsdT	sense

2048-2067	5455	UUAAGAAAAAAUUAUAACA	5456	UuAAGAAAAAAUuAuAAcAdTsdT	antis

2106-2125	5457	GCUGUACCCCUUCUUGUCC	5458	GcuGuAccccuucuuGuccdTsdT	sense

2106-2125	5459	GGACAAGAAGGGGUACAGC	5460	GGAcAAGAAGGGGuAcAGCdTsdT	antis

2109-2128	5461	GUACCCCUUCUUGUCCUCU	5462	GuAccccuucuuGuccucudTsdT	sense

2109-2128	5463	AGAGGACAAGAAGGGGUAC	5464	AGAGGAcAAGAAGGGGuACdTsdT	antis

2120-2139	5465	UGUCCUCUGCUCCCAAGGC	5466	uGuccucuGcucccAAGGcdTsdT	sense

2120-2139	5467	GCCUUGGGAGCAGAGGACA	5468	GCCUUGGGAGcAGAGGAcAdTsdT	antis

2170-2189	5469	AGUAGAGAGAGUCCCUGGU	5470	AGuAGAGAGAGucccuGGudTsdT	sense

2170-2189	5471	ACCAGGGACUCUCUCUACU	5472	ACcAGGGACUCUCUCuACUdTsdT	antis

2180-2199	5473	GUCCCUGGUGUCUUAGUUU	5474	GucccuGGuGucuuAGuuudTsdT	sense

2180-2199	5475	AAACUAAGACACCAGGGAC	5476	AAACuAAGAcACcAGGGACdTsdT	antis

2187-2206	5477	GUGUCUUAGUUUCCACAGU	5478	GuGucuuAGuuuccAcAGudTsdT	sense

2187-2206	5479	ACUGUGGAAACUAAGACAC	5480	ACUGUGGAAACuAAGAcACdTsdT	antis

2189-2208	5481	GUCUUAGUUUCCACAGUAA	5482	GucuuAGuuuccAcAGuAAdTsdT	sense

2189-2208	5483	UUACUGUGGAAACUAAGAC	5484	UuACUGUGGAAACuAAGACdTsdT	antis

2190-2209	5485	UCUUAGUUUCCACAGUAAG	5486	ucuuAGuuuccAcAGuAAGdTsdT	sense

2190-2209	5487	CUUACUGUGGAAACUAAGA	5488	CUuACUGUGGAAACuAAGAdTsdT	antis

2225-2244	5489	ACCUCUGUUCAAUAAAUUA	5490	AccucuGuucAAuAAAuuAdTsdT	sense

2225-2244	5491	UAAUUUAUUGAACAGAGGU	5492	uAAUUuAUUGAAcAGAGGUdTsdT	antis

2238-2257	5493	AAAUUAUUGGCAUGAAACC	5494	AAAuuAuuGGcAuGAAAccdTsdT	sense

2238-2257	5495	GGUUUCAUGCCAAUAAUUU	5496	GGUUUcAUGCcAAuAAUUUdTsdT	antis

2239-2258	5497	AAUUAUUGGCAUGAAACCC	5498	AAuuAuuGGcAuGAAAcccdTsdT	sense

2239-2258	5499	GGGUUUCAUGCCAAUAAUU	5500	GGGUUUcAUGCcAAuAAUUdTsdT	antis

2241-2260	5501	UUAUUGGCAUGAAACCCUU	5502	uuAuuGGcAuGAAAcccuudTsdT	sense

2241-2260	5503	AAGGGUUUCAUGCCAAUAA	5504	AAGGGUUUcAUGCcAAuAAdTsdT	antis

34-53	5505	CAUCUCCCGGCGUGCCCCG	5506	cAucucccGGcGuGccccGdTsdT	sense

34-53	5507	CGGGGCACGCCGGGAGAUG	5508	CGGGGcACGCCGGGAGAUGdTsdT	antis

35-54	5509	AUCUCCCGGCGUGCCCCGC	5510	AucucccGGcGuGccccGcdTsdT	sense

35-54	5511	GCGGGGCACGCCGGGAGAU	5512	GCGGGGcACGCCGGGAGAUdTsdT	antis

97-116	5513	GAAGAGGCCGGAGCCCAGG	5514	GAAGAGGccGGAGcccAGGdTsdT	sense

97-116	5515	CCUGGGCUCCGGCCUCUUC	5516	CCUGGGCUCCGGCCUCUUCdTsdT	antis

163-182	5517	CCCCGCGGCCUGGGCCUGC	5518	ccccGcGGccuGGGccuGcdTsdT	sense

163-182	5519	GCAGGCCCAGGCCGCGGGG	5520	GcAGGCCcAGGCCGCGGGGdTsdT	antis

164-183	5521	CCCGCGGCCUGGGCCUGCG	5522	cccGcGGccuGGGccuGcGdTsdT	sense

164-183	5523	CGCAGGCCCAGGCCGCGGG	5524	CGcAGGCCcAGGCCGCGGGdTsdT	antis

228-247	5525	GGCUCGGGCCGGGCGCGGA	5526	GGcucGGGccGGGcGcGGAdTsdT	sense

228-247	5527	UCCGCGCCCGGCCCGAGCC	5528	UCCGCGCCCGGCCCGAGCCdTsdT	antis

235-254	5529	GCCGGGCGCGGACCAGCUC	5530	GccGGGcGcGGAccAGcucdTsdT	sense

235-254	5531	GAGCUGGUCCGCGCCCGGC	5532	GAGCUGGUCCGCGCCCGGCdTsdT	antis

247-266	5533	CCAGCUCGUUCGCGGAGCC	5534	ccAGcucGuucGcGGAGccdTsdT	sense

247-266	5535	GGCUCCGCGAACGAGCUGG	5536	GGCUCCGCGAACGAGCUGGdTsdT	antis

262-281	5537	AGCCAGGAGGCGGAGGCGG	5538	AGccAGGAGGcGGAGGcGGdTsdT	sense

262-281	5539	CCGCCUCCGCCUCCUGGCU	5540	CCGCCUCCGCCUCCUGGCUdTsdT	antis

301-320	5541	GGGGCUCGGCCUCUGGCCC	5542	GGGGcucGGccucuGGcccdTsdT	sense

301-320	5543	GGGCCAGAGGCCGAGCCCC	5544	GGGCcAGAGGCCGAGCCCCdTsdT	antis

393-412	5545	GGCCCCAGCGGCAGCGGCG	5546	GGccccAGcGGcAGcGGcGdTsdT	sense

393-412	5547	CGCCGCUGCCGCUGGGGCC	5548	CGCCGCUGCCGCUGGGGCCdTsdT	antis

403-422	5549	GCAGCGGCGGAGGAGGCAG	5550	GcAGcGGcGGAGGAGGcAGdTsdT	sense

403-422	5551	CUGCCUCCUCCGCCGCUGC	5552	CUGCCUCCUCCGCCGCUGCdTsdT	antis

420-439	5553	AGCGGUGGCCCCGGCGCGG	5554	AGcGGuGGccccGGcGcGGdTsdT	sense

420-439	5555	CCGCGCCGGGGCCACCGCU	5556	CCGCGCCGGGGCcACCGCUdTsdT	antis

502-521	5557	UAGCCACUGUAGGCCAAGG	5558	uAGccAcuGuAGGccAAGGdTsdT	sense

502-521	5559	CCUUGGCCUACAGUGGCUA	5560	CCUUGGCCuAcAGUGGCuAdTsdT	antis

531-550	5561	UCCCAAGAAGUGGCUUACA	5562	ucccAAGAAGuGGcuuAcAdTsdT	sense

531-550	5563	UGUAAGCCACUUCUUGGGA	5564	UGuAAGCcACUUCUUGGGAdTsdT	antis

665-684	5565	CCGAGAACUGCAGAUUAUG	5566	ccGAGAAcuGcAGAuuAuGdTsdT	sense

665-684	5567	CAUAAUCUGCAGUUCUCGG	5568	cAuAAUCUGcAGUUCUCGGdTsdT	antis

1148-1167	5569	CUUCCCUGGGGACAGUGGG	5570	cuucccuGGGGAcAGuGGGdTsdT	sense

1148-1167	5571	CCCACUGUCCCCAGGGAAG	5572	CCcACUGUCCCcAGGGAAGdTsdT	antis

1356-1375	5573	CCAUCCUCAAGGCUCUCCC	5574	ccAuccucAAGGcucucccdTsdT	sense

1356-1375	5575	GGGAGAGCCUUGAGGAUGG	5576	GGGAGAGCCUUGAGGAUGGdTsdT	antis

1358-1377	5577	AUCCUCAAGGCUCUCCCCA	5578	AuccucAAGGcucuccccAdTsdT	sense

1358-1377	5579	UGGGGAGAGCCUUGAGGAU	5580	UGGGGAGAGCCUUGAGGAUdTsdT	antis

1485-1504	5581	UCCAUCCAACCAUCUCUCA	5582	uccAuccAAccAucucucAdTsdT	sense

1485-1504	5583	UGAGAGAUGGUUGGAUGGA	5584	UGAGAGAUGGUUGGAUGGAdTsdT	antis

1620-1639	5585	CAGCCAUCUGAUGCCACAA	5586	cAGccAucuGAuGccAcAAdTsdT	sense

1620-1639	5587	UUGUGGCAUCAGAUGGCUG	5588	UUGUGGcAUcAGAUGGCUGdTsdT	antis

1813-1832	5589	UCAGCAGCCUAACCUCUGU	5590	ucAGcAGccuAAccucuGudTsdT	sense

1813-1832	5591	ACAGAGGUUAGGCUGCUGA	5592	AcAGAGGUuAGGCUGCUGAdTsdT	antis

1954-1973	5593	CUUCCCUCCCCCCCUCUCC	5594	cuucccucccccccucuccdTsdT	sense

1954-1973	5595	GGAGAGGGGGGGAGGGAAG	5596	GGAGAGGGGGGGAGGGAAGdTsdT	antis

1957-1976	5597	CCCUCCCCCCCUCUCCCAG	5598	cccucccccccucucccAGdTsdT	sense

1957-1976	5599	CUGGGAGAGGGGGGGAGGG	5600	CUGGGAGAGGGGGGGAGGGdTsdT	antis

2103-2122	5601	CCAGCUGUACCCCUUCUUG	5602	ccAGcuGuAccccuucuuGdTsdT	sense

2103-2122	5603	CAAGAAGGGGUACAGCUGG	5604	cAAGAAGGGGuAcAGCUGGdTsdT	antis

2119-2138	5605	UUGUCCUCUGCUCCCAAGG	5606	uuGuccucuGcucccAAGGdTsdT	sense

2119-2138	5607	CCUUGGGAGCAGAGGACAA	5608	CCUUGGGAGcAGAGGAcAAdTsdT	antis

2122-2141	5609	UCCUCUGCUCCCAAGGCUU	5610	uccucuGcucccAAGGcuudTsdT	sense

2122-2141	5611	AAGCCUUGGGAGCAGAGGA	5612	AAGCCUUGGGAGcAGAGGAdTsdT	antis

2125-2144	5613	UCUGCUCCCAAGGCUUCCU	5614	ucuGcucccAAGGcuuccudTsdT	sense

2125-2144	5615	AGGAAGCCUUGGGAGCAGA	5616	AGGAAGCCUUGGGAGcAGAdTsdT	antis

2154-2173	5617	AUCCUGGAAGGAGGGGAGU	5618	AuccuGGAAGGAGGGGAGudTsdT	sense

2154-2173	5619	ACUCCCCUCCUUCCAGGAU	5620	ACUCCCCUCCUUCcAGGAUdTsdT	antis

33-52	5621	UCAUCUCCCGGCGUGCCCC	5622	ucAucucccGGcGuGccccdTsdT	sense

33-52	5623	GGGGCACGCCGGGAGAUGA	5624	GGGGcACGCCGGGAGAUGAdTsdT	antis

46-65	5625	UGCCCCGCGGCGGGCGCUG	5626	uGccccGcGGcGGGcGcuGdTsdT	sense

46-65	5627	CAGCGCCCGCCGCGGGGCA	5628	cAGCGCCCGCCGCGGGGcAdTsdT	antis

47-66	5629	GCCCCGCGGCGGGCGCUGG	5630	GccccGcGGcGGGcGcuGGdTsdT	sense

47-66	5631	CCAGCGCCCGCCGCGGGGC	5632	CcAGCGCCCGCCGCGGGGCdTsdT	antis

53-72	5633	CGGCGGGCGCUGGGCCGGA	5634	cGGcGGGcGcuGGGccGGAdTsdT	sense

53-72	5635	UCCGGCCCAGCGCCCGCCG	5636	UCCGGCCcAGCGCCCGCCGdTsdT	antis

54-73	5637	GGCGGGCGCUGGGCCGGAG	5638	GGcGGGcGcuGGGccGGAGdTsdT	sense

54-73	5639	CUCCGGCCCAGCGCCCGCC	5640	CUCCGGCCcAGCGCCCGCCdTsdT	antis

55-74	5641	GCGGGCGCUGGGCCGGAGC	5642	GcGGGcGcuGGGccGGAGcdTsdT	sense

55-74	5643	GCUCCGGCCCAGCGCCCGC	5644	GCUCCGGCCcAGCGCCCGCdTsdT	antis

61-80	5645	GCUGGGCCGGAGCCGGAGC	5646	GcuGGGccGGAGccGGAGcdTsdT	sense

61-80	5647	GCUCCGGCUCCGGCCCAGC	5648	GCUCCGGCUCCGGCCcAGCdTsdT	antis

64-83	5649	GGGCCGGAGCCGGAGCCCG	5650	GGGccGGAGccGGAGcccGdTsdT	sense

64-83	5651	CGGGCUCCGGCUCCGGCCC	5652	CGGGCUCCGGCUCCGGCCCdTsdT	antis

67-86	5653	CCGGAGCCGGAGCCCGAAC	5654	ccGGAGccGGAGcccGAAcdTsdT	sense

67-86	5655	GUUCGGGCUCCGGCUCCGG	5656	GUUCGGGCUCCGGCUCCGGdTsdT	antis

92-111	5657	GCCUGGAAGAGGCCGGAGC	5658	GccuGGAAGAGGccGGAGcdTsdT	sense

92-111	5659	GCUCCGGCCUCUUCCAGGC	5660	GCUCCGGCCUCUUCcAGGCdTsdT	antis

93-112	5661	CCUGGAAGAGGCCGGAGCC	5662	ccuGGAAGAGGccGGAGccdTsdT	sense

93-112	5663	GGCUCCGGCCUCUUCCAGG	5664	GGCUCCGGCCUCUUCcAGGdTsdT	antis

101-120	5665	AGGCCGGAGCCCAGGGGAG	5666	AGGccGGAGcccAGGGGAGdTsdT	sense

101-120	5667	CUCCCCUGGGCUCCGGCCU	5668	CUCCCCUGGGCUCCGGCCUdTsdT	antis

102-121	5669	GGCCGGAGCCCAGGGGAGG	5670	GGccGGAGcccAGGGGAGGdTsdT	sense

102-121	5671	CCUCCCCUGGGCUCCGGCC	5672	CCUCCCCUGGGCUCCGGCCdTsdT	antis

106-125	5673	GGAGCCCAGGGGAGGCGGC	5674	GGAGcccAGGGGAGGcGGcdTsdT	sense

106-125	5675	GCCGCCUCCCCUGGGCUCC	5676	GCCGCCUCCCCUGGGCUCCdTsdT	antis

110-129	5677	CCCAGGGGAGGCGGCGGCA	5678	cccAGGGGAGGcGGcGGcAdTsdT	sense

110-129	5679	UGCCGCCGCCUCCCCUGGG	5680	UGCCGCCGCCUCCCCUGGGdTsdT	antis

111-130	5681	CCAGGGGAGGCGGCGGCAG	5682	ccAGGGGAGGcGGcGGcAGdTsdT	sense

111-130	5683	CUGCCGCCGCCUCCCCUGG	5684	CUGCCGCCGCCUCCCCUGGdTsdT	antis

122-141	5685	GGCGGCAGAGGCAGCGGCG	5686	GGcGGcAGAGGcAGcGGcGdTsdT	sense

122-141	5687	CGCCGCUGCCUCUGCCGCC	5688	CGCCGCUGCCUCUGCCGCCdTsdT	antis

123-142	5689	GCGGCAGAGGCAGCGGCGG	5690	GcGGcAGAGGcAGcGGcGGdTsdT	sense

123-142	5691	CCGCCGCUGCCUCUGCCGC	5692	CCGCCGCUGCCUCUGCCGCdTsdT	antis

124-143	5693	CGGCAGAGGCAGCGGCGGG	5694	cGGcAGAGGcAGcGGcGGGdTsdT	sense

124-143	5695	CCCGCCGCUGCCUCUGCCG	5696	CCCGCCGCUGCCUCUGCCGdTsdT	antis

125-144	5697	GGCAGAGGCAGCGGCGGGG	5698	GGcAGAGGcAGcGGcGGGGdTsdT	sense

125-144	5699	CCCCGCCGCUGCCUCUGCC	5700	CCCCGCCGCUGCCUCUGCCdTsdT	antis

132-151	5701	GCAGCGGCGGGGGCAGCCC	5702	GcAGcGGcGGGGGcAGcccdTsdT	sense

132-151	5703	GGGCUGCCCCCGCCGCUGC	5704	GGGCUGCCCCCGCCGCUGCdTsdT	antis

139-158	5705	CGGGGGCAGCCCAGGCAGC	5706	cGGGGGcAGcccAGGcAGcdTsdT	sense

139-158	5707	GCUGCCUGGGCUGCCCCCG	5708	GCUGCCUGGGCUGCCCCCGdTsdT	antis

143-162	5709	GGCAGCCCAGGCAGCCCGA	5710	GGcAGcccAGGcAGcccGAdTsdT	sense

143-162	5711	UCGGGCUGCCUGGGCUGCC	5712	UCGGGCUGCCUGGGCUGCCdTsdT	antis

146-165	5713	AGCCCAGGCAGCCCGAGCC	5714	AGcccAGGcAGcccGAGccdTsdT	sense

146-165	5715	GGCUCGGGCUGCCUGGGCU	5716	GGCUCGGGCUGCCUGGGCUdTsdT	antis

152-171	5717	GGCAGCCCGAGCCCCGCGG	5718	GGcAGcccGAGccccGcGGdTsdT	sense

152-171	5719	CCGCGGGGCUCGGGCUGCC	5720	CCGCGGGGCUCGGGCUGCCdTsdT	antis

154-173	5721	CAGCCCGAGCCCCGCGGCC	5722	cAGcccGAGccccGcGGccdTsdT	sense

154-173	5723	GGCCGCGGGGCUCGGGCUG	5724	GGCCGCGGGGCUCGGGCUGdTsdT	antis

155-174	5725	AGCCCGAGCCCCGCGGCCU	5726	AGcccGAGccccGcGGccudTsdT	sense

155-174	5727	AGGCCGCGGGGCUCGGGCU	5728	AGGCCGCGGGGCUCGGGCUdTsdT	antis

156-175	5729	GCCCGAGCCCCGCGGCCUG	5730	GcccGAGccccGcGGccuGdTsdT	sense

156-175	5731	CAGGCCGCGGGGCUCGGGC	5732	cAGGCCGCGGGGCUCGGGCdTsdT	antis

159-178	5733	CGAGCCCCGCGGCCUGGGC	5734	cGAGccccGcGGccuGGGcdTsdT	sense

159-178	5735	GCCCAGGCCGCGGGGCUCG	5736	GCCcAGGCCGCGGGGCUCGdTsdT	antis

160-179	5737	GAGCCCCGCGGCCUGGGCC	5738	GAGccccGcGGccuGGGccdTsdT	sense

160-179	5739	GGCCCAGGCCGCGGGGCUC	5740	GGCCcAGGCCGCGGGGCUCdTsdT	antis

161-180	5741	AGCCCCGCGGCCUGGGCCU	5742	AGccccGcGGccuGGGccudTsdT	sense

161-180	5743	AGGCCCAGGCCGCGGGGCU	5744	AGGCCcAGGCCGCGGGGCUdTsdT	antis

162-181	5745	GCCCCGCGGCCUGGGCCUG	5746	GccccGcGGccuGGGccuGdTsdT	sense

162-181	5747	CAGGCCCAGGCCGCGGGGC	5748	cAGGCCcAGGCCGCGGGGCdTsdT	antis

174-193	5749	GGGCCUGCGCUCGGCGCCA	5750	GGGccuGcGcucGGcGccAdTsdT	sense

174-193	5751	UGGCGCCGAGCGCAGGCCC	5752	UGGCGCCGAGCGcAGGCCCdTsdT	antis

210-229	5753	UCGGGAGGCGGCCCUGGGG	5754	ucGGGAGGcGGcccuGGGGdTsdT	sense

210-229	5755	CCCCAGGGCCGCCUCCCGA	5756	CCCcAGGGCCGCCUCCCGAdTsdT	antis

211-230	5757	CGGGAGGCGGCCCUGGGGG	5758	cGGGAGGcGGcccuGGGGGdTsdT	sense

211-230	5759	CCCCCAGGGCCGCCUCCCG	5760	CCCCcAGGGCCGCCUCCCGdTsdT	antis

212-231	5761	GGGAGGCGGCCCUGGGGGC	5762	GGGAGGcGGcccuGGGGGcdTsdT	sense

212-231	5763	GCCCCCAGGGCCGCCUCCC	5764	GCCCCcAGGGCCGCCUCCCdTsdT	antis

217-236	5765	GCGGCCCUGGGGGCUCGGG	5766	GcGGcccuGGGGGcucGGGdTsdT	sense

217-236	5767	CCCGAGCCCCCAGGGCCGC	5768	CCCGAGCCCCcAGGGCCGCdTsdT	antis

218-237	5769	CGGCCCUGGGGGCUCGGGC	5770	cGGcccuGGGGGcucGGGcdTsdT	sense

218-237	5771	GCCCGAGCCCCCAGGGCCG	5772	GCCCGAGCCCCcAGGGCCGdTsdT	antis

225-244	5773	GGGGGCUCGGGCCGGGCGC	5774	GGGGGcucGGGccGGGcGcdTsdT	sense

225-244	5775	GCGCCCGGCCCGAGCCCCC	5776	GCGCCCGGCCCGAGCCCCCdTsdT	antis

226-245	5777	GGGGCUCGGGCCGGGCGCG	5778	GGGGcucGGGccGGGcGcGdTsdT	sense

226-245	5779	CGCGCCCGGCCCGAGCCCC	5780	CGCGCCCGGCCCGAGCCCCdTsdT	antis

232-251	5781	CGGGCCGGGCGCGGACCAG	5782	cGGGccGGGcGcGGAccAGdTsdT	sense

232-251	5783	CUGGUCCGCGCCCGGCCCG	5784	CUGGUCCGCGCCCGGCCCGdTsdT	antis

260-279	5785	GGAGCCAGGAGGCGGAGGC	5786	GGAGccAGGAGGcGGAGGcdTsdT	sense

260-279	5787	GCCUCCGCCUCCUGGCUCC	5788	GCCUCCGCCUCCUGGCUCCdTsdT	antis

263-282	5789	GCCAGGAGGCGGAGGCGGA	5790	GccAGGAGGcGGAGGcGGAdTsdT	sense

263-282	5791	UCCGCCUCCGCCUCCUGGC	5792	UCCGCCUCCGCCUCCUGGCdTsdT	antis

264-283	5793	CCAGGAGGCGGAGGCGGAG	5794	ccAGGAGGcGGAGGcGGAGdTsdT	sense

264-283	5795	CUCCGCCUCCGCCUCCUGG	5796	CUCCGCCUCCGCCUCCUGGdTsdT	antis

270-289	5797	GGCGGAGGCGGAGGUGGUG	5798	GGcGGAGGcGGAGGuGGuGdTsdT	sense

270-289	5799	CACCACCUCCGCCUCCGCC	5800	cACcACCUCCGCCUCCGCCdTsdT	antis

280-299	5801	GAGGUGGUGGCGGCGGCCC	5802	GAGGuGGuGGcGGcGGcccdTsdT	sense

280-299	5803	GGGCCGCCGCCACCACCUC	5804	GGGCCGCCGCcACcACCUCdTsdT	antis

281-300	5805	AGGUGGUGGCGGCGGCCCC	5806	AGGuGGuGGcGGcGGccccdTsdT	sense

281-300	5807	GGGGCCGCCGCCACCACCU	5808	GGGGCCGCCGCcACcACCUdTsdT	antis

282-301	5809	GGUGGUGGCGGCGGCCCCG	5810	GGuGGuGGcGGcGGccccGdTsdT	sense

282-301	5811	CGGGGCCGCCGCCACCACC	5812	CGGGGCCGCCGCcACcACCdTsdT	antis

283-302	5813	GUGGUGGCGGCGGCCCCGG	5814	GuGGuGGcGGcGGccccGGdTsdT	sense

283-302	5815	CCGGGGCCGCCGCCACCAC	5816	CCGGGGCCGCCGCcACcACdTsdT	antis

289-308	5817	GCGGCGGCCCCGGGGGCUC	5818	GcGGcGGccccGGGGGcucdTsdT	sense

289-308	5819	GAGCCCCCGGGGCCGCCGC	5820	GAGCCCCCGGGGCCGCCGCdTsdT	antis

291-310	5821	GGCGGCCCCGGGGGCUCGG	5822	GGcGGccccGGGGGcucGGdTsdT	sense

291-310	5823	CCGAGCCCCCGGGGCCGCC	5824	CCGAGCCCCCGGGGCCGCCdTsdT	antis

296-315	5825	CCCCGGGGGCUCGGCCUCU	5826	ccccGGGGGcucGGccucudTsdT	sense

296-315	5827	AGAGGCCGAGCCCCCGGGG	5828	AGAGGCCGAGCCCCCGGGGdTsdT	antis

303-322	5829	GGCUCGGCCUCUGGCCCAG	5830	GGcucGGccucuGGcccAGdTsdT	sense

303-322	5831	CUGGGCCAGAGGCCGAGCC	5832	CUGGGCcAGAGGCCGAGCCdTsdT	antis

320-339	5833	AGGAGGCACUGGCGGCGGG	5834	AGGAGGcAcuGGcGGcGGGdTsdT	sense

320-339	5835	CCCGCCGCCAGUGCCUCCU	5836	CCCGCCGCcAGUGCCUCCUdTsdT	antis

382-401	5837	GCUCCGGGGGUGGCCCCAG	5838	GcuccGGGGGuGGccccAGdTsdT	sense

382-401	5839	CUGGGGCCACCCCCGGAGC	5840	CUGGGGCcACCCCCGGAGCdTsdT	antis

383-402	5841	CUCCGGGGGUGGCCCCAGC	5842	cuccGGGGGuGGccccAGcdTsdT	sense

383-402	5843	GCUGGGGCCACCCCCGGAG	5844	GCUGGGGCcACCCCCGGAGdTsdT	antis

395-414	5845	CCCCAGCGGCAGCGGCGGA	5846	ccccAGcGGcAGcGGcGGAdTsdT	sense

395-414	5847	UCCGCCGCUGCCGCUGGGG	5848	UCCGCCGCUGCCGCUGGGGdTsdT	antis

396-415	5849	CCCAGCGGCAGCGGCGGAG	5850	cccAGcGGcAGcGGcGGAGdTsdT	sense

396-415	5851	CUCCGCCGCUGCCGCUGGG	5852	CUCCGCCGCUGCCGCUGGGdTsdT	antis

397-416	5853	CCAGCGGCAGCGGCGGAGG	5854	ccAGcGGcAGcGGcGGAGGdTsdT	sense

397-416	5855	CCUCCGCCGCUGCCGCUGG	5856	CCUCCGCCGCUGCCGCUGGdTsdT	antis

398-417	5857	CAGCGGCAGCGGCGGAGGA	5858	cAGcGGcAGcGGcGGAGGAdTsdT	sense

398-417	5859	UCCUCCGCCGCUGCCGCUG	5860	UCCUCCGCCGCUGCCGCUGdTsdT	antis

400-419	5861	GCGGCAGCGGCGGAGGAGG	5862	GcGGcAGcGGcGGAGGAGGdTsdT	sense

400-419	5863	CCUCCUCCGCCGCUGCCGC	5864	CCUCCUCCGCCGCUGCCGCdTsdT	antis

405-424	5865	AGCGGCGGAGGAGGCAGCG	5866	AGcGGcGGAGGAGGcAGcGdTsdT	sense

405-424	5867	CGCUGCCUCCUCCGCCGCU	5868	CGCUGCCUCCUCCGCCGCUdTsdT	antis

406-425	5869	GCGGCGGAGGAGGCAGCGG	5870	GcGGcGGAGGAGGcAGcGGdTsdT	sense

406-425	5871	CCGCUGCCUCCUCCGCCGC	5872	CCGCUGCCUCCUCCGCCGCdTsdT	antis

407-426	5873	CGGCGGAGGAGGCAGCGGU	5874	cGGcGGAGGAGGcAGcGGudTsdT	sense

407-426	5875	ACCGCUGCCUCCUCCGCCG	5876	ACCGCUGCCUCCUCCGCCGdTsdT	antis

408-427	5877	GGCGGAGGAGGCAGCGGUG	5878	GGcGGAGGAGGcAGcGGuGdTsdT	sense

408-427	5879	CACCGCUGCCUCCUCCGCC	5880	cACCGCUGCCUCCUCCGCCdTsdT	antis

444-463	5881	AGCUUCCCGCCGCCGGGAG	5882	AGcuucccGccGccGGGAGdTsdT	sense

444-463	5883	CUCCCGGCGGCGGGAAGCU	5884	CUCCCGGCGGCGGGAAGCUdTsdT	antis

461-480	5885	AGUGAAGCUGGGCCGUGAC	5886	AGuGAAGcuGGGccGuGAcdTsdT	sense

461-480	5887	GUCACGGCCCAGCUUCACU	5888	GUcACGGCCcAGCUUcACUdTsdT	antis

493-512	5889	CCACAGUGGUAGCCACUGU	5890	ccAcAGuGGuAGccAcuGudTsdT	sense

493-512	5891	ACAGUGGCUACCACUGUGG	5892	AcAGUGGCuACcACUGUGGdTsdT	antis

513-532	5893	GGCCAAGGCCCAGAGCGUU	5894	GGccAAGGcccAGAGcGuudTsdT	sense

513-532	5895	AACGCUCUGGGCCUUGGCC	5896	AACGCUCUGGGCCUUGGCCdTsdT	antis

606-625	5897	GCAGAGACGAGGGAACUGG	5898	GcAGAGAcGAGGGAAcuGGdTsdT	sense

606-625	5899	CCAGUUCCCUCGUCUCUGC	5900	CcAGUUCCCUCGUCUCUGCdTsdT	antis

616-635	5901	GGGAACUGGUGGCCAUCAA	5902	GGGAAcuGGuGGccAucAAdTsdT	sense

616-635	5903	UUGAUGGCCACCAGUUCCC	5904	UUGAUGGCcACcAGUUCCCdTsdT	antis

620-639	5905	ACUGGUGGCCAUCAAGAAG	5906	AcuGGuGGccAucAAGAAGdTsdT	sense

620-639	5907	CUUCUUGAUGGCCACCAGU	5908	CUUCUUGAUGGCcACcAGUdTsdT	antis

621-640	5909	CUGGUGGCCAUCAAGAAGG	5910	cuGGuGGccAucAAGAAGGdTsdT	sense

621-640	5911	CCUUCUUGAUGGCCACCAG	5912	CCUUCUUGAUGGCcACcAGdTsdT	antis

711-730	5913	AGGCUGCGGUACUUUUUCU	5914	AGGcuGcGGuAcuuuuucudTsdT	sense

711-730	5915	AGAAAAAGUACCGCAGCCU	5916	AGAAAAAGuACCGcAGCCUdTsdT	antis

712-731	5917	GGCUGCGGUACUUUUUCUA	5918	GGcuGcGGuAcuuuuucuAdTsdT	sense

712-731	5919	UAGAAAAAGUACCGCAGCC	5920	uAGAAAAAGuACCGcAGCCdTsdT	antis

716-735	5921	GCGGUACUUUUUCUACUCC	5922	GcGGuAcuuuuucuAcuccdTsdT	sense

716-735	5923	GGAGUAGAAAAAGUACCGC	5924	GGAGuAGAAAAAGuACCGCdTsdT	antis

851-870	5925	CAUCAAGGUGUACAUGUAC	5926	cAucAAGGuGuAcAuGuAcdTsdT	sense

851-870	5927	GUACAUGUACACCUUGAUG	5928	GuAcAUGuAcACCUUGAUGdTsdT	antis

891-910	5929	UACAUCCACUCCCAAGGUG	5930	uAcAuccAcucccAAGGuGdTsdT	sense

891-910	5931	CACCUUGGGAGUGGAUGUA	5932	cACCUUGGGAGUGGAUGuAdTsdT	antis

948-967	5933	GACCCUGACACUGCUGUCC	5934	GAcccuGAcAcuGcuGuccdTsdT	sense

948-967	5935	GGACAGCAGUGUCAGGGUC	5936	GGAcAGcAGUGUcAGGGUCdTsdT	antis

951-970	5937	CCUGACACUGCUGUCCUCA	5938	ccuGAcAcuGcuGuccucAdTsdT	sense

951-970	5939	UGAGGACAGCAGUGUCAGG	5940	UGAGGAcAGcAGUGUcAGGdTsdT	antis

955-974	5941	ACACUGCUGUCCUCAAGCU	5942	AcAcuGcuGuccucAAGcudTsdT	sense

955-974	5943	AGCUUGAGGACAGCAGUGU	5944	AGCUUGAGGAcAGcAGUGUdTsdT	antis

956-975	5945	CACUGCUGUCCUCAAGCUC	5946	cAcuGcuGuccucAAGcucdTsdT	sense

956-975	5947	GAGCUUGAGGACAGCAGUG	5948	GAGCUUGAGGAcAGcAGUGdTsdT	antis

958-977	5949	CUGCUGUCCUCAAGCUCUG	5950	cuGcuGuccucAAGcucuGdTsdT	sense

958-977	5951	CAGAGCUUGAGGACAGCAG	5952	cAGAGCUUGAGGAcAGcAGdTsdT	antis

959-978	5953	UGCUGUCCUCAAGCUCUGC	5954	uGcuGuccucAAGcucuGcdTsdT	sense

959-978	5955	GCAGAGCUUGAGGACAGCA	5956	GcAGAGCUUGAGGAcAGcAdTsdT	antis

1028-1047	5957	CAUCUGCUCUCGGUACUAC	5958	cAucuGcucucGGuAcuAcdTsdT	sense

1028-1047	5959	GUAGUACCGAGAGCAGAUG	5960	GuAGuACCGAGAGcAGAUGdTsdT	antis

1052-1071	5961	UCCAGAACUCAUCUUUGGA	5962	uccAGAAcucAucuuuGGAdTsdT	sense

1052-1071	5963	UCCAAAGAUGAGUUCUGGA	5964	UCcAAAGAUGAGUUCUGGAdTsdT	antis

1084-1103	5965	CCUCGUCCAUCGAUGUGUG	5966	ccucGuccAucGAuGuGuGdTsdT	sense

1084-1103	5967	CACACAUCGAUGGACGAGG	5968	cAcAcAUCGAUGGACGAGGdTsdT	antis

1103-1122	5969	GUCGGCUGGCUGUGUACUU	5970	GucGGcuGGcuGuGuAcuudTsdT	sense

1103-1122	5971	AAGUACACAGCCAGCCGAC	5972	AAGuAcAcAGCcAGCCGACdTsdT	antis

1111-1130	5973	GCUGUGUACUUGCUGAGCU	5974	GcuGuGuAcuuGcuGAGcudTsdT	sense

1111-1130	5975	AGCUCAGCAAGUACACAGC	5976	AGCUcAGcAAGuAcAcAGCdTsdT	antis

1116-1135	5977	GUACUUGCUGAGCUACUUC	5978	GuAcuuGcuGAGcuAcuucdTsdT	sense

1116-1135	5979	GAAGUAGCUCAGCAAGUAC	5980	GAAGuAGCUcAGcAAGuACdTsdT	antis

1132-1151	5981	UUCUCGGCCAGCCCAUCUU	5982	uucucGGccAGcccAucuudTsdT	sense

1132-1151	5983	AAGAUGGGCUGGCCGAGAA	5984	AAGAUGGGCUGGCCGAGAAdTsdT	antis

1133-1152	5985	UCUCGGCCAGCCCAUCUUC	5986	ucucGGccAGcccAucuucdTsdT	sense

1133-1152	5987	GAAGAUGGGCUGGCCGAGA	5988	GAAGAUGGGCUGGCCGAGAdTsdT	antis

1136-1155	5989	CGGCCAGCCCAUCUUCCCU	5990	cGGccAGcccAucuucccudTsdT	sense

1136-1155	5991	AGGGAAGAUGGGCUGGCCG	5992	AGGGAAGAUGGGCUGGCCGdTsdT	antis

1143-1162	5993	CCCAUCUUCCCUGGGGACA	5994	cccAucuucccuGGGGAcAdTsdT	sense

1143-1162	5995	UGUCCCCAGGGAAGAUGGG	5996	UGUCCCcAGGGAAGAUGGGdTsdT	antis

1147-1166	5997	UCUUCCCUGGGGACAGUGG	5998	ucuucccuGGGGAcAGuGGdTsdT	sense

1147-1166	5999	CCACUGUCCCCAGGGAAGA	6000	CcACUGUCCCcAGGGAAGAdTsdT	antis

1152-1171	6001	CCUGGGGACAGUGGGGUGG	6002	ccuGGGGAcAGuGGGGuGGdTsdT	sense

1152-1171	6003	CCACCCCACUGUCCCCAGG	6004	CcACCCcACUGUCCCcAGGdTsdT	antis

1161-1180	6005	AGUGGGGUGGACCAGCUUG	6006	AGuGGGGuGGAccAGcuuGdTsdT	sense

1161-1180	6007	CAAGCUGGUCCACCCCACU	6008	cAAGCUGGUCcACCCcACUdTsdT	antis

1277-1296	6009	CCCUUGGACAAAGGUGUUC	6010	cccuuGGAcAAAGGuGuucdTsdT	sense

1277-1296	6011	GAACACCUUUGUCCAAGGG	6012	GAAcACCUUUGUCcAAGGGdTsdT	antis

1298-1317	6013	AUCUUCAAAGACACCACCU	6014	AucuucAAAGAcAccAccudTsdT	sense

1298-1317	6015	AGGUGGUGUCUUUGAAGAU	6016	AGGUGGUGUCUUUGAAGAUdTsdT	antis

1300-1319	6017	CUUCAAAGACACCACCUGA	6018	cuucAAAGAcAccAccuGAdTsdT	sense

1300-1319	6019	UCAGGUGGUGUCUUUGAAG	6020	UcAGGUGGUGUCUUUGAAGdTsdT	antis

1301-1320	6021	UUCAAAGACACCACCUGAG	6022	uucAAAGAcAccAccuGAGdTsdT	sense

1301-1320	6023	CUCAGGUGGUGUCUUUGAA	6024	CUcAGGUGGUGUCUUUGAAdTsdT	antis

1357-1376	6025	CAUCCUCAAGGCUCUCCCC	6026	cAuccucAAGGcucuccccdTsdT	sense

1357-1376	6027	GGGGAGAGCCUUGAGGAUG	6028	GGGGAGAGCCUUGAGGAUGdTsdT	antis

1390-1409	6029	CCCACAGCUUCUUCGAUGA	6030	cccAcAGcuucuucGAuGAdTsdT	sense

1390-1409	6031	UCAUCGAAGAAGCUGUGGG	6032	UcAUCGAAGAAGCUGUGGGdTsdT	antis

1419-1438	6033	CUCGGAGCCCAGCUCCCCA	6034	cucGGAGcccAGcuccccAdTsdT	sense

1419-1438	6035	UGGGGAGCUGGGCUCCGAG	6036	UGGGGAGCUGGGCUCCGAGdTsdT	antis

1421-1440	6037	CGGAGCCCAGCUCCCCAAC	6038	cGGAGcccAGcuccccAAcdTsdT	sense

1421-1440	6039	GUUGGGGAGCUGGGCUCCG	6040	GUUGGGGAGCUGGGCUCCGdTsdT	antis

1497-1516	6041	UCUCUCAAUGCCAUUCUCA	6042	ucucucAAuGccAuucucAdTsdT	sense

1497-1516	6043	UGAGAAUGGCAUUGAGAGA	6044	UGAGAAUGGcAUUGAGAGAdTsdT	antis

1500-1519	6045	CUCAAUGCCAUUCUCAUCC	6046	cucAAuGccAuucucAuccdTsdT	sense

1500-1519	6047	GGAUGAGAAUGGCAUUGAG	6048	GGAUGAGAAUGGcAUUGAGdTsdT	antis

1501-1520	6049	UCAAUGCCAUUCUCAUCCC	6050	ucAAuGccAuucucAucccdTsdT	sense

1501-1520	6051	GGGAUGAGAAUGGCAUUGA	6052	GGGAUGAGAAUGGcAUUGAdTsdT	antis

1540-1559	6053	CAGGCCCUGCUUCUCCCCU	6054	cAGGcccuGcuucuccccudTsdT	sense

1540-1559	6055	AGGGGAGAAGCAGGGCCUG	6056	AGGGGAGAAGcAGGGCCUGdTsdT	antis

1547-1566	6057	UGCUUCUCCCCUCACCACU	6058	uGcuucuccccucAccAcudTsdT	sense

1547-1566	6059	AGUGGUGAGGGGAGAAGCA	6060	AGUGGUGAGGGGAGAAGcAdTsdT	antis

1586-1605	6061	AGCUUUAACUGAAGCUCAG	6062	AGcuuuAAcuGAAGcucAGdTsdT	sense

1586-1605	6063	CUGAGCUUCAGUUAAAGCU	6064	CUGAGCUUcAGUuAAAGCUdTsdT	antis

1621-1640	6065	AGCCAUCUGAUGCCACAAC	6066	AGccAucuGAuGccAcAAcdTsdT	sense

1621-1640	6067	GUUGUGGCAUCAGAUGGCU	6068	GUUGUGGcAUcAGAUGGCUdTsdT	antis

1818-1837	6069	AGCCUAACCUCUGUGGUGG	6070	AGccuAAccucuGuGGuGGdTsdT	sense

1818-1837	6071	CCACCACAGAGGUUAGGCU	6072	CcACcAcAGAGGUuAGGCUdTsdT	antis

1865-1884	6073	UAGGGGAGGGGAGAAAAGG	6074	uAGGGGAGGGGAGAAAAGGdTsdT	sense

1865-1884	6075	CCUUUUCUCCCCUCCCCUA	6076	CCUUUUCUCCCCUCCCCuAdTsdT	antis

1866-1885	6077	AGGGGAGGGGAGAAAAGGA	6078	AGGGGAGGGGAGAAAAGGAdTsdT	sense

1866-1885	6079	UCCUUUUCUCCCCUCCCCU	6080	UCCUUUUCUCCCCUCCCCUdTsdT	antis

1867-1886	6081	GGGGAGGGGAGAAAAGGAA	6082	GGGGAGGGGAGAAAAGGAAdTsdT	sense

1867-1886	6083	UUCCUUUUCUCCCCUCCCC	6084	UUCCUUUUCUCCCCUCCCCdTsdT	antis

1868-1887	6085	GGGAGGGGAGAAAAGGAAG	6086	GGGAGGGGAGAAAAGGAAGdTsdT	sense

1868-1887	6087	CUUCCUUUUCUCCCCUCCC	6088	CUUCCUUUUCUCCCCUCCCdTsdT	antis

1872-1891	6089	GGGGAGAAAAGGAAGGACG	6090	GGGGAGAAAAGGAAGGAcGdTsdT	sense

1872-1891	6091	CGUCCUUCCUUUUCUCCCC	6092	CGUCCUUCCUUUUCUCCCCdTsdT	antis

1901-1920	6093	GUGUGAGGACCUUCUACCC	6094	GuGuGAGGAccuucuAcccdTsdT	sense

1901-1920	6095	GGGUAGAAGGUCCUCACAC	6096	GGGuAGAAGGUCCUcAcACdTsdT	antis

1929-1948	6097	CCUCCCCUCCCCCAGGCUA	6098	ccuccccucccccAGGcuAdTsdT	sense

1929-1948	6099	UAGCCUGGGGGAGGGGAGG	6100	uAGCCUGGGGGAGGGGAGGdTsdT	antis

1930-1949	6101	CUCCCCUCCCCCAGGCUAC	6102	cuccccucccccAGGcuAcdTsdT	sense

1930-1949	6103	GUAGCCUGGGGGAGGGGAG	6104	GuAGCCUGGGGGAGGGGAGdTsdT	antis

1947-1966	6105	ACCACUCCUUCCCUCCCCC	6106	AccAcuccuucccucccccdTsdT	sense

1947-1966	6107	GGGGGAGGGAAGGAGUGGU	6108	GGGGGAGGGAAGGAGUGGUdTsdT	antis

1948-1967	6109	CCACUCCUUCCCUCCCCCC	6110	ccAcuccuucccuccccccdTsdT	sense

1948-1967	6111	GGGGGGAGGGAAGGAGUGG	6112	GGGGGGAGGGAAGGAGUGGdTsdT	antis

1949-1968	6113	CACUCCUUCCCUCCCCCCC	6114	cAcuccuucccucccccccdTsdT	sense

1949-1968	6115	GGGGGGGAGGGAAGGAGUG	6116	GGGGGGGAGGGAAGGAGUGdTsdT	antis

1950-1969	6117	ACUCCUUCCCUCCCCCCCU	6118	AcuccuucccucccccccudTsdT	sense

1950-1969	6119	AGGGGGGGAGGGAAGGAGU	6120	AGGGGGGGAGGGAAGGAGUdTsdT	antis

1951-1970	6121	CUCCUUCCCUCCCCCCCUC	6122	cuccuucccucccccccucdTsdT	sense

1951-1970	6123	GAGGGGGGGAGGGAAGGAG	6124	GAGGGGGGGAGGGAAGGAGdTsdT	antis

1955-1974	6125	UUCCCUCCCCCCCUCUCCC	6126	uucccucccccccucucccdTsdT	sense

1955-1974	6127	GGGAGAGGGGGGGAGGGAA	6128	GGGAGAGGGGGGGAGGGAAdTsdT	antis

1956-1975	6129	UCCCUCCCCCCCUCUCCCA	6130	ucccucccccccucucccAdTsdT	sense

1956-1975	6131	UGGGAGAGGGGGGGAGGGA	6132	UGGGAGAGGGGGGGAGGGAdTsdT	antis

1965-1984	6133	CCCUCUCCCAGGUCCCUUG	6134	cccucucccAGGucccuuGdTsdT	sense

1965-1984	6135	CAAGGGACCUGGGAGAGGG	6136	cAAGGGACCUGGGAGAGGGdTsdT	antis

1971-1990	6137	CCCAGGUCCCUUGUAAAUA	6138	cccAGGucccuuGuAAAuAdTsdT	sense

1971-1990	6139	UAUUUACAAGGGACCUGGG	6140	uAUUuAcAAGGGACCUGGGdTsdT	antis

1988-2007	6141	UAGAACCAGCCCAGCCCAU	6142	uAGAAccAGcccAGcccAudTsdT	sense

1988-2007	6143	AUGGGCUGGGCUGGUUCUA	6144	AUGGGCUGGGCUGGUUCuAdTsdT	antis

2005-2024	6145	AUCUCUCGUCUUCCCUUCC	6146	AucucucGucuucccuuccdTsdT	sense

2005-2024	6147	GGAAGGGAAGACGAGAGAU	6148	GGAAGGGAAGACGAGAGAUdTsdT	antis

2006-2025	6149	UCUCUCGUCUUCCCUUCCC	6150	ucucucGucuucccuucccdTsdT	sense

2006-2025	6151	GGGAAGGGAAGACGAGAGA	6152	GGGAAGGGAAGACGAGAGAdTsdT	antis

2020-2039	6153	UUCCCUGGCCCCCUGGGUG	6154	uucccuGGcccccuGGGuGdTsdT	sense

2020-2039	6155	CACCCAGGGGGCCAGGGAA	6156	cACCcAGGGGGCcAGGGAAdTsdT	antis

2039-2058	6157	UAAAUAGAUUGUUAUAAUU	6158	uAAAuAGAuuGuuAuAAuudTsdT	sense

2039-2058	6159	AAUUAUAACAAUCUAUUUA	6160	AAUuAuAAcAAUCuAUUuAdTsdT	antis

2050-2069	6161	UUAUAAUUUUUUCUUAAAG	6162	uuAuAAuuuuuucuuAAAGdTsdT	sense

2050-2069	6163	CUUUAAGAAAAAAUUAUAA	6164	CUUuAAGAAAAAAUuAuAAdTsdT	antis

2052-2071	6165	AUAAUUUUUUCUUAAAGAA	6166	AuAAuuuuuucuuAAAGAAdTsdT	sense

2052-2071	6167	UUCUUUAAGAAAAAAUUAU	6168	UUCUUuAAGAAAAAAUuAUdTsdT	antis

2053-2072	6169	UAAUUUUUUCUUAAAGAAA	6170	uAAuuuuuucuuAAAGAAAdTsdT	sense

2053-2072	6171	UUUCUUUAAGAAAAAAUUA	6172	UUUCUUuAAGAAAAAAUuAdTsdT	antis

2054-2073	6173	AAUUUUUUCUUAAAGAAAA	6174	AAuuuuuucuuAAAGAAAAdTsdT	sense

2054-2073	6175	UUUUCUUUAAGAAAAAAUU	6176	UUUUCUUuAAGAAAAAAUUdTsdT	antis

2110-2129	6177	UACCCCUUCUUGUCCUCUG	6178	uAccccuucuuGuccucuGdTsdT	sense

2110-2129	6179	CAGAGGACAAGAAGGGGUA	6180	cAGAGGAcAAGAAGGGGuAdTsdT	antis

2112-2131	6181	CCCCUUCUUGUCCUCUGCU	6182	ccccuucuuGuccucuGcudTsdT	sense

2112-2131	6183	AGCAGAGGACAAGAAGGGG	6184	AGcAGAGGAcAAGAAGGGGdTsdT	antis

2113-2132	6185	CCCUUCUUGUCCUCUGCUC	6186	cccuucuuGuccucuGcucdTsdT	sense

2113-2132	6187	GAGCAGAGGACAAGAAGGG	6188	GAGcAGAGGAcAAGAAGGGdTsdT	antis

2114-2133	6189	CCUUCUUGUCCUCUGCUCC	6190	ccuucuuGuccucuGcuccdTsdT	sense

2114-2133	6191	GGAGCAGAGGACAAGAAGG	6192	GGAGcAGAGGAcAAGAAGGdTsdT	antis

2115-2134	6193	CUUCUUGUCCUCUGCUCCC	6194	cuucuuGuccucuGcucccdTsdT	sense

2115-2134	6195	GGGAGCAGAGGACAAGAAG	6196	GGGAGcAGAGGAcAAGAAGdTsdT	antis

2126-2145	6197	CUGCUCCCAAGGCUUCCUC	6198	cuGcucccAAGGcuuccucdTsdT	sense

2126-2145	6199	GAGGAAGCCUUGGGAGCAG	6200	GAGGAAGCCUUGGGAGcAGdTsdT	antis

2131-2150	6201	CCCAAGGCUUCCUCCCUCU	6202	cccAAGGcuuccucccucudTsdT	sense

2131-2150	6203	AGAGGGAGGAAGCCUUGGG	6204	AGAGGGAGGAAGCCUUGGGdTsdT	antis

2137-2156	6205	GCUUCCUCCCUCUCCCCAU	6206	GcuuccucccucuccccAudTsdT	sense

2137-2156	6207	AUGGGGAGAGGGAGGAAGC	6208	AUGGGGAGAGGGAGGAAGCdTsdT	antis

2138-2157	6209	CUUCCUCCCUCUCCCCAUC	6210	cuuccucccucuccccAucdTsdT	sense

2138-2157	6211	GAUGGGGAGAGGGAGGAAG	6212	GAUGGGGAGAGGGAGGAAGdTsdT	antis

2140-2159	6213	UCCUCCCUCUCCCCAUCCU	6214	uccucccucuccccAuccudTsdT	sense

2140-2159	6215	AGGAUGGGGAGAGGGAGGA	6216	AGGAUGGGGAGAGGGAGGAdTsdT	antis

2141-2160	6217	CCUCCCUCUCCCCAUCCUG	6218	ccucccucuccccAuccuGdTsdT	sense

2141-2160	6219	CAGGAUGGGGAGAGGGAGG	6220	cAGGAUGGGGAGAGGGAGGdTsdT	antis

2145-2164	6221	CCUCUCCCCAUCCUGGAAG	6222	ccucuccccAuccuGGAAGdTsdT	sense

2145-2164	6223	CUUCCAGGAUGGGGAGAGG	6224	CUUCcAGGAUGGGGAGAGGdTsdT	antis

2153-2172	6225	CAUCCUGGAAGGAGGGGAG	6226	cAuccuGGAAGGAGGGGAGdTsdT	sense

2153-2172	6227	CUCCCCUCCUUCCAGGAUG	6228	CUCCCCUCCUUCcAGGAUGdTsdT	antis

2172-2191	6229	UAGAGAGAGUCCCUGGUGU	6230	uAGAGAGAGucccuGGuGudTsdT	sense

2172-2191	6231	ACACCAGGGACUCUCUCUA	6232	AcACcAGGGACUCUCUCuAdTsdT	antis

2186-2205	6233	GGUGUCUUAGUUUCCACAG	6234	GGuGucuuAGuuuccAcAGdTsdT	sense

2186-2205	6235	CUGUGGAAACUAAGACACC	6236	CUGUGGAAACuAAGAcACCdTsdT	antis

2193-2212	6237	UAGUUUCCACAGUAAGGUU	6238	uAGuuuccAcAGuAAGGuudTsdT	sense

2193-2212	6239	AACCUUACUGUGGAAACUA	6240	AACCUuACUGUGGAAACuAdTsdT	antis

2240-2259	6241	AUUAUUGGCAUGAAACCCU	6242	AuuAuuGGcAuGAAAcccudTsdT	sense

2240-2259	6243	AGGGUUUCAUGCCAAUAAU	6244	AGGGUUUcAUGCcAAuAAUdTsdT	antis

62-81	6245	CUGGGCCGGAGCCGGAGCC	6246	cuGGGccGGAGccGGAGccdTsdT	sense

62-81	6247	GGCUCCGGCUCCGGCCCAG	6248	GGCUCCGGCUCCGGCCcAGdTsdT	antis

120-139	6249	GCGGCGGCAGAGGCAGCGG	6250	GcGGcGGcAGAGGcAGcGGdTsdT	sense

120-139	6251	CCGCUGCCUCUGCCGCCGC	6252	CCGCUGCCUCUGCCGCCGCdTsdT	antis

121-140	6253	CGGCGGCAGAGGCAGCGGC	6254	cGGcGGcAGAGGcAGcGGcdTsdT	sense

121-140	6255	GCCGCUGCCUCUGCCGCCG	6256	GCCGCUGCCUCUGCCGCCGdTsdT	antis

127-146	6257	CAGAGGCAGCGGCGGGGGC	6258	cAGAGGcAGcGGcGGGGGcdTsdT	sense

127-146	6259	GCCCCCGCCGCUGCCUCUG	6260	GCCCCCGCCGCUGCCUCUGdTsdT	antis

142-161	6261	GGGCAGCCCAGGCAGCCCG	6262	GGGcAGcccAGGcAGcccGdTsdT	sense

142-161	6263	CGGGCUGCCUGGGCUGCCC	6264	CGGGCUGCCUGGGCUGCCCdTsdT	antis

267-286	6265	GGAGGCGGAGGCGGAGGUG	6266	GGAGGcGGAGGcGGAGGuGdTsdT	sense

267-286	6267	CACCUCCGCCUCCGCCUCC	6268	cACCUCCGCCUCCGCCUCCdTsdT	antis

268-287	6269	GAGGCGGAGGCGGAGGUGG	6270	GAGGcGGAGGcGGAGGuGGdTsdT	sense

268-287	6271	CCACCUCCGCCUCCGCCUC	6272	CcACCUCCGCCUCCGCCUCdTsdT	antis

271-290	6273	GCGGAGGCGGAGGUGGUGG	6274	GcGGAGGcGGAGGuGGuGGdTsdT	sense

271-290	6275	CCACCACCUCCGCCUCCGC	6276	CcACcACCUCCGCCUCCGCdTsdT	antis

284-303	6277	UGGUGGCGGCGGCCCCGGG	6278	uGGuGGcGGcGGccccGGGdTsdT	sense

284-303	6279	CCCGGGGCCGCCGCCACCA	6280	CCCGGGGCCGCCGCcACcAdTsdT	antis

591-610	6281	UACCAGGCACGGCUGGCAG	6282	uAccAGGcAcGGcuGGcAGdTsdT	sense

591-610	6283	CUGCCAGCCGUGCCUGGUA	6284	CUGCcAGCCGUGCCUGGuAdTsdT	antis

1131-1150	6285	CUUCUCGGCCAGCCCAUCU	6286	cuucucGGccAGcccAucudTsdT	sense

1131-1150	6287	AGAUGGGCUGGCCGAGAAG	6288	AGAUGGGCUGGCCGAGAAGdTsdT	antis

1299-1318	6289	UCUUCAAAGACACCACCUG	6290	ucuucAAAGAcAccAccuGdTsdT	sense

1299-1318	6291	CAGGUGGUGUCUUUGAAGA	6292	cAGGUGGUGUCUUUGAAGAdTsdT	antis

1558-1577	6293	UCACCACUUCCUACAACCC	6294	ucAccAcuuccuAcAAcccdTsdT	sense

1558-1577	6295	GGGUUGUAGGAAGUGGUGA	6296	GGGUUGuAGGAAGUGGUGAdTsdT	antis

1927-1946	6297	CCCCUCCCCUCCCCCAGGC	6298	ccccuccccucccccAGGcdTsdT	sense

1927-1946	6299	GCCUGGGGGAGGGGAGGGG	6300	GCCUGGGGGAGGGGAGGGGdTsdT	antis

1928-1947	6301	CCCUCCCCUCCCCCAGGCU	6302	cccuccccucccccAGGcudTsdT	sense

1928-1947	6303	AGCCUGGGGGAGGGGAGGG	6304	AGCCUGGGGGAGGGGAGGGdTsdT	antis

2111-2130	6305	ACCCCUUCUUGUCCUCUGC	6306	AccccuucuuGuccucuGcdTsdT	sense

2111-2130	6307	GCAGAGGACAAGAAGGGGU	6308	GcAGAGGAcAAGAAGGGGUdTsdT	antis

2142-2161	6309	CUCCCUCUCCCCAUCCUGG	6310	cucccucuccccAuccuGGdTsdT	sense

2142-2161	6311	CCAGGAUGGGGAGAGGGAG	6312	CcAGGAUGGGGAGAGGGAGdTsdT	antis

2144-2163	6313	CCCUCUCCCCAUCCUGGAA	6314	cccucuccccAuccuGGAAdTsdT	sense

2144-2163	6315	UUCCAGGAUGGGGAGAGGG	6316	UUCcAGGAUGGGGAGAGGGdTsdT	antis

1671-1690	6317	CACCGACUACCCCUCCACG	6318	cAccGAcuAccccuccAcGdTsdT	sense

1671-1690	6319	CGUGGAGGGGUAGUCGGUG	6320	CGUGGAGGGGuAGUCGGUGdTsdT	antis

1673-1692	6321	CCGACUACCCCUCCACGUC	6322	ccGAcuAccccuccAcGucdTsdT	sense

1673-1692	6323	GACGUGGAGGGGUAGUCGG	6324	GACGUGGAGGGGuAGUCGGdTsdT	antis

1036-1055	6325	CUCGGUACUACCGUGCUCC	6326	cucGGuAcuAccGuGcuccdTsdT	sense

1036-1055	6327	GGAGCACGGUAGUACCGAG	6328	GGAGcACGGuAGuACCGAGdTsdT	antis

1035-1054	6329	UCUCGGUACUACCGUGCUC	6330	ucucGGuAcuAccGuGcucdTsdT	sense

1035-1054	6331	GAGCACGGUAGUACCGAGA	6332	GAGcACGGuAGuACCGAGAdTsdT	antis

1042-1061	6333	ACUACCGUGCUCCAGAACU	6334	AcuAccGuGcuccAGAAcudTsdT	sense

1042-1061	6335	AGUUCUGGAGCACGGUAGU	6336	AGUUCUGGAGcACGGuAGUdTsdT	antis

1674-1693	6337	CGACUACCCCUCCACGUCC	6338	cGAcuAccccuccAcGuccdTsdT	sense

1674-1693	6339	GGACGUGGAGGGGUAGUCG	6340	GGACGUGGAGGGGuAGUCGdTsdT	antis

1787-1806	6341	AACUACCCCCAGCAUCUAG	6342	AAcuAcccccAGcAucuAGdTsdT	sense

1787-1806	6343	CUAGAUGCUGGGGGUAGUU	6344	CuAGAUGCUGGGGGuAGUUdTsdT	antis

1034-1053	6345	CUCUCGGUACUACCGUGCU	6346	cucucGGuAcuAccGuGcudTsdT	sense

1034-1053	6347	AGCACGGUAGUACCGAGAG	6348	AGcACGGuAGuACCGAGAGdTsdT	antis

1202-1221	6349	AACGCCAACCAGGGAACAA	6350	AAcGccAAccAGGGAAcAAdTsdT	sense

1202-1221	6351	UUGUUCCCUGGUUGGCGUU	6352	UUGUUCCCUGGUUGGCGUUdTsdT	antis

776-795	6353	GGAGUAUGUGCCCGAGACG	6354	GGAGuAuGuGcccGAGAcGdTsdT	sense

776-795	6355	CGUCUCGGGCACAUACUCC	6356	CGUCUCGGGcAcAuACUCCdTsdT	antis

779-798	6357	GUAUGUGCCCGAGACGGUG	6358	GuAuGuGcccGAGAcGGuGdTsdT	sense

779-798	6359	CACCGUCUCGGGCACAUAC	6360	cACCGUCUCGGGcAcAuACdTsdT	antis

780-799	6361	UAUGUGCCCGAGACGGUGU	6362	uAuGuGcccGAGAcGGuGudTsdT	sense

780-799	6363	ACACCGUCUCGGGCACAUA	6364	AcACCGUCUCGGGcAcAuAdTsdT	antis

973-992	6365	UCUGCGAUUUUGGCAGUGC	6366	ucuGcGAuuuuGGcAGuGcdTsdT	sense

973-992	6367	GCACUGCCAAAAUCGCAGA	6368	GcACUGCcAAAAUCGcAGAdTsdT	antis

1038-1057	6369	CGGUACUACCGUGCUCCAG	6370	cGGuAcuAccGuGcuccAGdTsdT	sense

1038-1057	6371	CUGGAGCACGGUAGUACCG	6372	CUGGAGcACGGuAGuACCGdTsdT	antis

1041-1060	6373	UACUACCGUGCUCCAGAAC	6374	uAcuAccGuGcuccAGAAcdTsdT	sense

1041-1060	6375	GUUCUGGAGCACGGUAGUA	6376	GUUCUGGAGcACGGuAGuAdTsdT	antis

1043-1062	6377	CUACCGUGCUCCAGAACUC	6378	cuAccGuGcuccAGAAcucdTsdT	sense

1043-1062	6379	GAGUUCUGGAGCACGGUAG	6380	GAGUUCUGGAGcACGGuAGdTsdT	antis

1189-1208	6381	UCAAGGUACUAGGAACGCC	6382	ucAAGGuAcuAGGAAcGccdTsdT	sense

1189-1208	6383	GGCGUUCCUAGUACCUUGA	6384	GGCGUUCCuAGuACCUUGAdTsdT	antis

1190-1209	6385	CAAGGUACUAGGAACGCCA	6386	cAAGGuAcuAGGAAcGccAdTsdT	sense

1190-1209	6387	UGGCGUUCCUAGUACCUUG	6388	UGGCGUUCCuAGuACCUUGdTsdT	antis

1191-1210	6389	AAGGUACUAGGAACGCCAA	6390	AAGGuAcuAGGAAcGccAAdTsdT	sense

1191-1210	6391	UUGGCGUUCCUAGUACCUU	6392	UUGGCGUUCCuAGuACCUUdTsdT	antis

1192-1211	6393	AGGUACUAGGAACGCCAAC	6394	AGGuAcuAGGAAcGccAAcdTsdT	sense

1192-1211	6395	GUUGGCGUUCCUAGUACCU	6396	GUUGGCGUUCCuAGuACCUdTsdT	antis

1197-1216	6397	CUAGGAACGCCAACCAGGG	6398	cuAGGAAcGccAAccAGGGdTsdT	sense

1197-1216	6399	CCCUGGUUGGCGUUCCUAG	6400	CCCUGGUUGGCGUUCCuAGdTsdT	antis

1203-1222	6401	ACGCCAACCAGGGAACAAA	6402	AcGccAAccAGGGAAcAAAdTsdT	sense

1203-1222	6403	UUUGUUCCCUGGUUGGCGU	6404	UUUGUUCCCUGGUUGGCGUdTsdT	antis

1670-1689	6405	CCACCGACUACCCCUCCAC	6406	ccAccGAcuAccccuccAcdTsdT	sense

1670-1689	6407	GUGGAGGGGUAGUCGGUGG	6408	GUGGAGGGGuAGUCGGUGGdTsdT	antis

1672-1691	6409	ACCGACUACCCCUCCACGU	6410	AccGAcuAccccuccAcGudTsdT	sense

1672-1691	6411	ACGUGGAGGGGUAGUCGGU	6412	ACGUGGAGGGGuAGUCGGUdTsdT	antis

1780-1799	6413	GUAAAUGAACUACCCCCAG	6414	GuAAAuGAAcuAcccccAGdTsdT	sense

1780-1799	6415	CUGGGGGUAGUUCAUUUAC	6416	CUGGGGGuAGUUcAUUuACdTsdT	antis

1786-1805	6417	GAACUACCCCCAGCAUCUA	6418	GAAcuAcccccAGcAucuAdTsdT	sense

1786-1805	6419	UAGAUGCUGGGGGUAGUUC	6420	uAGAUGCUGGGGGuAGUUCdTsdT	antis

352-371	6421	GGGCUAUGGGUGGGGGCGU	6422	GGGcuAuGGGuGGGGGcGudTsdT	sense

352-371	6423	ACGCCCCCACCCAUAGCCC	6424	ACGCCCCcACCcAuAGCCCdTsdT	antis

354-373	6425	GCUAUGGGUGGGGGCGUGG	6426	GcuAuGGGuGGGGGcGuGGdTsdT	sense

354-373	6427	CCACGCCCCCACCCAUAGC	6428	CcACGCCCCcACCcAuAGCdTsdT	antis

521-540	6429	CCCAGAGCGUUCCCAAGAA	6430	cccAGAGcGuucccAAGAAdTsdT	sense

521-540	6431	UUCUUGGGAACGCUCUGGG	6432	UUCUUGGGAACGCUCUGGGdTsdT	antis

523-542	6433	CAGAGCGUUCCCAAGAAGU	6434	cAGAGcGuucccAAGAAGudTsdT	sense

523-542	6435	ACUUCUUGGGAACGCUCUG	6436	ACUUCUUGGGAACGCUCUGdTsdT	antis

524-543	6437	AGAGCGUUCCCAAGAAGUG	6438	AGAGcGuucccAAGAAGuGdTsdT	sense

524-543	6439	CACUUCUUGGGAACGCUCU	6440	cACUUCUUGGGAACGCUCUdTsdT	antis

527-546	6441	GCGUUCCCAAGAAGUGGCU	6442	GcGuucccAAGAAGuGGcudTsdT	sense

527-546	6443	AGCCACUUCUUGGGAACGC	6444	AGCcACUUCUUGGGAACGCdTsdT	antis

550-569	6445	CUGACAUCAAAGUGAUUGG	6446	cuGAcAucAAAGuGAuuGGdTsdT	sense

550-569	6447	CCAAUCACUUUGAUGUCAG	6448	CcAAUcACUUUGAUGUcAGdTsdT	antis

568-587	6449	GUAAUGGCUCAUUCGGAGU	6450	GuAAuGGcucAuucGGAGudTsdT	sense

568-587	6451	ACUCCGAAUGAGCCAUUAC	6452	ACUCCGAAUGAGCcAUuACdTsdT	antis

569-588	6453	UAAUGGCUCAUUCGGAGUA	6454	uAAuGGcucAuucGGAGuAdTsdT	sense

569-588	6455	UACUCCGAAUGAGCCAUUA	6456	uACUCCGAAUGAGCcAUuAdTsdT	antis

570-589	6457	AAUGGCUCAUUCGGAGUAG	6458	AAuGGcucAuucGGAGuAGdTsdT	sense

570-589	6459	CUACUCCGAAUGAGCCAUU	6460	CuACUCCGAAUGAGCcAUUdTsdT	antis

572-591	6461	UGGCUCAUUCGGAGUAGUA	6462	uGGcucAuucGGAGuAGuAdTsdT	sense

572-591	6463	UACUACUCCGAAUGAGCCA	6464	uACuACUCCGAAUGAGCcAdTsdT	antis

626-645	6465	GGCCAUCAAGAAGGUUCUU	6466	GGccAucAAGAAGGuucuudTsdT	sense

626-645	6467	AAGAACCUUCUUGAUGGCC	6468	AAGAACCUUCUUGAUGGCCdTsdT	antis

688-707	6469	AGCUGGACCACUGCAAUAU	6470	AGcuGGAccAcuGcAAuAudTsdT	sense

688-707	6471	AUAUUGCAGUGGUCCAGCU	6472	AuAUUGcAGUGGUCcAGCUdTsdT	antis

693-712	6473	GACCACUGCAAUAUUGUGA	6474	GAccAcuGcAAuAuuGuGAdTsdT	sense

693-712	6475	UCACAAUAUUGCAGUGGUC	6476	UcAcAAuAUUGcAGUGGUCdTsdT	antis

697-716	6477	ACUGCAAUAUUGUGAGGCU	6478	AcuGcAAuAuuGuGAGGcudTsdT	sense

697-716	6479	AGCCUCACAAUAUUGCAGU	6480	AGCCUcAcAAuAUUGcAGUdTsdT	antis

724-743	6481	UUUUCUACUCCAGUGGGGA	6482	uuuucuAcuccAGuGGGGAdTsdT	sense

724-743	6483	UCCCCACUGGAGUAGAAAA	6484	UCCCcACUGGAGuAGAAAAdTsdT	antis

725-744	6485	UUUCUACUCCAGUGGGGAG	6486	uuucuAcuccAGuGGGGAGdTsdT	sense

725-744	6487	CUCCCCACUGGAGUAGAAA	6488	CUCCCcACUGGAGuAGAAAdTsdT	antis

726-745	6489	UUCUACUCCAGUGGGGAGA	6490	uucuAcuccAGuGGGGAGAdTsdT	sense

726-745	6491	UCUCCCCACUGGAGUAGAA	6492	UCUCCCcACUGGAGuAGAAdTsdT	antis

727-746	6493	UCUACUCCAGUGGGGAGAA	6494	ucuAcuccAGuGGGGAGAAdTsdT	sense

727-746	6495	UUCUCCCCACUGGAGUAGA	6496	UUCUCCCcACUGGAGuAGAdTsdT	antis

757-776	6497	UGUAUUUGAAUCUGGUGCU	6498	uGuAuuuGAAucuGGuGcudTsdT	sense

757-776	6499	AGCACCAGAUUCAAAUACA	6500	AGcACcAGAUUcAAAuAcAdTsdT	antis

759-778	6501	UAUUUGAAUCUGGUGCUGG	6502	uAuuuGAAucuGGuGcuGGdTsdT	sense

759-778	6503	CCAGCACCAGAUUCAAAUA	6504	CcAGcACcAGAUUcAAAuAdTsdT	antis

760-779	6505	AUUUGAAUCUGGUGCUGGA	6506	AuuuGAAucuGGuGcuGGAdTsdT	sense

760-779	6507	UCCAGCACCAGAUUCAAAU	6508	UCcAGcACcAGAUUcAAAUdTsdT	antis

762-781	6509	UUGAAUCUGGUGCUGGAGU	6510	uuGAAucuGGuGcuGGAGudTsdT	sense

762-781	6511	ACUCCAGCACCAGAUUCAA	6512	ACUCcAGcACcAGAUUcAAdTsdT	antis

763-782	6513	UGAAUCUGGUGCUGGAGUA	6514	uGAAucuGGuGcuGGAGuAdTsdT	sense

763-782	6515	UACUCCAGCACCAGAUUCA	6516	uACUCcAGcACcAGAUUcAdTsdT	antis

775-794	6517	UGGAGUAUGUGCCCGAGAC	6518	uGGAGuAuGuGcccGAGAcdTsdT	sense

775-794	6519	GUCUCGGGCACAUACUCCA	6520	GUCUCGGGcAcAuACUCcAdTsdT	antis

778-797	6521	AGUAUGUGCCCGAGACGGU	6522	AGuAuGuGcccGAGAcGGudTsdT	sense

778-797	6523	ACCGUCUCGGGCACAUACU	6524	ACCGUCUCGGGcAcAuACUdTsdT	antis

854-873	6525	CAAGGUGUACAUGUACCAG	6526	cAAGGuGuAcAuGuAccAGdTsdT	sense

854-873	6527	CUGGUACAUGUACACCUUG	6528	CUGGuAcAUGuAcACCUUGdTsdT	antis

855-874	6529	AAGGUGUACAUGUACCAGC	6530	AAGGuGuAcAuGuAccAGcdTsdT	sense

855-874	6531	GCUGGUACAUGUACACCUU	6532	GCUGGuAcAUGuAcACCUUdTsdT	antis

856-875	6533	AGGUGUACAUGUACCAGCU	6534	AGGuGuAcAuGuAccAGcudTsdT	sense

856-875	6535	AGCUGGUACAUGUACACCU	6536	AGCUGGuAcAUGuAcACCUdTsdT	antis

857-876	6537	GGUGUACAUGUACCAGCUC	6538	GGuGuAcAuGuAccAGcucdTsdT	sense

857-876	6539	GAGCUGGUACAUGUACACC	6540	GAGCUGGuAcAUGuAcACCdTsdT	antis

915-934	6541	CACCGUGACAUCAAGCCCC	6542	cAccGuGAcAucAAGccccdTsdT	sense

915-934	6543	GGGGCUUGAUGUCACGGUG	6544	GGGGCUUGAUGUcACGGUGdTsdT	antis

938-957	6545	UUUGCUUGUGGACCCUGAC	6546	uuuGcuuGuGGAcccuGAcdTsdT	sense

938-957	6547	GUCAGGGUCCACAAGCAAA	6548	GUcAGGGUCcAcAAGcAAAdTsdT	antis

945-964	6549	GUGGACCCUGACACUGCUG	6550	GuGGAcccuGAcAcuGcuGdTsdT	sense

945-964	6551	CAGCAGUGUCAGGGUCCAC	6552	cAGcAGUGUcAGGGUCcACdTsdT	antis

971-990	6553	GCUCUGCGAUUUUGGCAGU	6554	GcucuGcGAuuuuGGcAGudTsdT	sense

971-990	6555	ACUGCCAAAAUCGCAGAGC	6556	ACUGCcAAAAUCGcAGAGCdTsdT	antis

972-991	6557	CUCUGCGAUUUUGGCAGUG	6558	cucuGcGAuuuuGGcAGuGdTsdT	sense

972-991	6559	CACUGCCAAAAUCGCAGAG	6560	cACUGCcAAAAUCGcAGAGdTsdT	antis

975-994	6561	UGCGAUUUUGGCAGUGCAA	6562	uGcGAuuuuGGcAGuGcAAdTsdT	sense

975-994	6563	UUGCACUGCCAAAAUCGCA	6564	UUGcACUGCcAAAAUCGcAdTsdT	antis

979-998	6565	AUUUUGGCAGUGCAAAGCA	6566	AuuuuGGcAGuGcAAAGcAdTsdT	sense

979-998	6567	UGCUUUGCACUGCCAAAAU	6568	UGCUUUGcACUGCcAAAAUdTsdT	antis

1037-1056	6569	UCGGUACUACCGUGCUCCA	6570	ucGGuAcuAccGuGcuccAdTsdT	sense

1037-1056	6571	UGGAGCACGGUAGUACCGA	6572	UGGAGcACGGuAGuACCGAdTsdT	antis

1040-1059	6573	GUACUACCGUGCUCCAGAA	6574	GuAcuAccGuGcuccAGAAdTsdT	sense

1040-1059	6575	UUCUGGAGCACGGUAGUAC	6576	UUCUGGAGcACGGuAGuACdTsdT	antis

1169-1188	6577	GGACCAGCUUGUGGAGAUC	6578	GGAccAGcuuGuGGAGAucdTsdT	sense

1169-1188	6579	GAUCUCCACAAGCUGGUCC	6580	GAUCUCcAcAAGCUGGUCCdTsdT	antis

1174-1193	6581	AGCUUGUGGAGAUCAUCAA	6582	AGcuuGuGGAGAucAucAAdTsdT	sense

1174-1193	6583	UUGAUGAUCUCCACAAGCU	6584	UUGAUGAUCUCcAcAAGCUdTsdT	antis

1178-1197	6585	UGUGGAGAUCAUCAAGGUA	6586	uGuGGAGAucAucAAGGuAdTsdT	sense

1178-1197	6587	UACCUUGAUGAUCUCCACA	6588	uACCUUGAUGAUCUCcAcAdTsdT	antis

1183-1202	6589	AGAUCAUCAAGGUACUAGG	6590	AGAucAucAAGGuAcuAGGdTsdT	sense

1183-1202	6591	CCUAGUACCUUGAUGAUCU	6592	CCuAGuACCUUGAUGAUCUdTsdT	antis

1193-1212	6593	GGUACUAGGAACGCCAACC	6594	GGuAcuAGGAAcGccAAccdTsdT	sense

1193-1212	6595	GGUUGGCGUUCCUAGUACC	6596	GGUUGGCGUUCCuAGuACCdTsdT	antis

1194-1213	6597	GUACUAGGAACGCCAACCA	6598	GuAcuAGGAAcGccAAccAdTsdT	sense

1194-1213	6599	UGGUUGGCGUUCCUAGUAC	6600	UGGUUGGCGUUCCuAGuACdTsdT	antis

1195-1214	6601	UACUAGGAACGCCAACCAG	6602	uAcuAGGAAcGccAAccAGdTsdT	sense

1195-1214	6603	CUGGUUGGCGUUCCUAGUA	6604	CUGGUUGGCGUUCCuAGuAdTsdT	antis

1198-1217	6605	UAGGAACGCCAACCAGGGA	6606	uAGGAAcGccAAccAGGGAdTsdT	sense

1198-1217	6607	UCCCUGGUUGGCGUUCCUA	6608	UCCCUGGUUGGCGUUCCuAdTsdT	antis

1199-1218	6609	AGGAACGCCAACCAGGGAA	6610	AGGAAcGccAAccAGGGAAdTsdT	sense

1199-1218	6611	UUCCCUGGUUGGCGUUCCU	6612	UUCCCUGGUUGGCGUUCCUdTsdT	antis

1200-1219	6613	GGAACGCCAACCAGGGAAC	6614	GGAAcGccAAccAGGGAAcdTsdT	sense

1200-1219	6615	GUUCCCUGGUUGGCGUUCC	6616	GUUCCCUGGUUGGCGUUCCdTsdT	antis

1201-1220	6617	GAACGCCAACCAGGGAACA	6618	GAAcGccAAccAGGGAAcAdTsdT	sense

1201-1220	6619	UGUUCCCUGGUUGGCGUUC	6620	UGUUCCCUGGUUGGCGUUCdTsdT	antis

1206-1225	6621	CCAACCAGGGAACAAAUCC	6622	ccAAccAGGGAAcAAAuccdTsdT	sense

1206-1225	6623	GGAUUUGUUCCCUGGUUGG	6624	GGAUUUGUUCCCUGGUUGGdTsdT	antis

1208-1227	6625	AACCAGGGAACAAAUCCGA	6626	AAccAGGGAAcAAAuccGAdTsdT	sense

1208-1227	6627	UCGGAUUUGUUCCCUGGUU	6628	UCGGAUUUGUUCCCUGGUUdTsdT	antis

1218-1237	6629	CAAAUCCGAGAGAUGAACC	6630	cAAAuccGAGAGAuGAAccdTsdT	sense

1218-1237	6631	GGUUCAUCUCUCGGAUUUG	6632	GGUUcAUCUCUCGGAUUUGdTsdT	antis

1220-1239	6633	AAUCCGAGAGAUGAACCCU	6634	AAuccGAGAGAuGAAcccudTsdT	sense

1220-1239	6635	AGGGUUCAUCUCUCGGAUU	6636	AGGGUUcAUCUCUCGGAUUdTsdT	antis

1221-1240	6637	AUCCGAGAGAUGAACCCUA	6638	AuccGAGAGAuGAAcccuAdTsdT	sense

1221-1240	6639	UAGGGUUCAUCUCUCGGAU	6640	uAGGGUUcAUCUCUCGGAUdTsdT	antis

1453-1472	6641	CCCCCCUGUUCAACUUCAG	6642	ccccccuGuucAAcuucAGdTsdT	sense

1453-1472	6643	CUGAAGUUGAACAGGGGGG	6644	CUGAAGUUGAAcAGGGGGGdTsdT	antis

1675-1694	6645	GACUACCCCUCCACGUCCA	6646	GAcuAccccuccAcGuccAdTsdT	sense

1675-1694	6647	UGGACGUGGAGGGGUAGUC	6648	UGGACGUGGAGGGGuAGUCdTsdT	antis

1676-1695	6649	ACUACCCCUCCACGUCCAU	6650	AcuAccccuccAcGuccAudTsdT	sense

1676-1695	6651	AUGGACGUGGAGGGGUAGU	6652	AUGGACGUGGAGGGGuAGUdTsdT	antis

1677-1696	6653	CUACCCCUCCACGUCCAUC	6654	cuAccccuccAcGuccAucdTsdT	sense

1677-1696	6655	GAUGGACGUGGAGGGGUAG	6656	GAUGGACGUGGAGGGGuAGdTsdT	antis

1703-1722	6657	GCCCAAGUGGCGCUGGGAA	6658	GcccAAGuGGcGcuGGGAAdTsdT	sense

1703-1722	6659	UUCCCAGCGCCACUUGGGC	6660	UUCCcAGCGCcACUUGGGCdTsdT	antis

1706-1725	6661	CAAGUGGCGCUGGGAAGGG	6662	cAAGuGGcGcuGGGAAGGGdTsdT	sense

1706-1725	6663	CCCUUCCCAGCGCCACUUG	6664	CCCUUCCcAGCGCcACUUGdTsdT	antis

1752-1771	6665	GGCUGGGCCCCUAGACUAG	6666	GGcuGGGccccuAGAcuAGdTsdT	sense

1752-1771	6667	CUAGUCUAGGGGCCCAGCC	6668	CuAGUCuAGGGGCCcAGCCdTsdT	antis

1755-1774	6669	UGGGCCCCUAGACUAGAGG	6670	uGGGccccuAGAcuAGAGGdTsdT	sense

1755-1774	6671	CCUCUAGUCUAGGGGCCCA	6672	CCUCuAGUCuAGGGGCCcAdTsdT	antis

1758-1777	6673	GCCCCUAGACUAGAGGGCA	6674	GccccuAGAcuAGAGGGcAdTsdT	sense

1758-1777	6675	UGCCCUCUAGUCUAGGGGC	6676	UGCCCUCuAGUCuAGGGGCdTsdT	antis

1761-1780	6677	CCUAGACUAGAGGGCAGAG	6678	ccuAGAcuAGAGGGcAGAGdTsdT	sense

1761-1780	6679	CUCUGCCCUCUAGUCUAGG	6680	CUCUGCCCUCuAGUCuAGGdTsdT	antis

1765-1784	6681	GACUAGAGGGCAGAGGUAA	6682	GAcuAGAGGGcAGAGGuAAdTsdT	sense

1765-1784	6683	UUACCUCUGCCCUCUAGUC	6684	UuACCUCUGCCCUCuAGUCdTsdT	antis

1777-1796	6685	GAGGUAAAUGAACUACCCC	6686	GAGGuAAAuGAAcuAccccdTsdT	sense

1777-1796	6687	GGGGUAGUUCAUUUACCUC	6688	GGGGuAGUUcAUUuACCUCdTsdT	antis

1778-1797	6689	AGGUAAAUGAACUACCCCC	6690	AGGuAAAuGAAcuAcccccdTsdT	sense

1778-1797	6691	GGGGGUAGUUCAUUUACCU	6692	GGGGGuAGUUcAUUuACCUdTsdT	antis

1779-1798	6693	GGUAAAUGAACUACCCCCA	6694	GGuAAAuGAAcuAcccccAdTsdT	sense

1779-1798	6695	UGGGGGUAGUUCAUUUACC	6696	UGGGGGuAGUUcAUUuACCdTsdT	antis

1781-1800	6697	UAAAUGAACUACCCCCAGC	6698	uAAAuGAAcuAcccccAGcdTsdT	sense

1781-1800	6699	GCUGGGGGUAGUUCAUUUA	6700	GCUGGGGGuAGUUcAUUuAdTsdT	antis

1792-1811	6701	CCCCCAGCAUCUAGGCCUC	6702	cccccAGcAucuAGGccucdTsdT	sense

1792-1811	6703	GAGGCCUAGAUGCUGGGGG	6704	GAGGCCuAGAUGCUGGGGGdTsdT	antis

1796-1815	6705	CAGCAUCUAGGCCUCCCUC	6706	cAGcAucuAGGccucccucdTsdT	sense

1796-1815	6707	GAGGGAGGCCUAGAUGCUG	6708	GAGGGAGGCCuAGAUGCUGdTsdT	antis

1885-1904	6709	AGGACGGGGUUUGGGGGUG	6710	AGGAcGGGGuuuGGGGGuGdTsdT	sense

1885-1904	6711	CACCCCCAAACCCCGUCCU	6712	cACCCCcAAACCCCGUCCUdTsdT	antis

522-541	6713	CCAGAGCGUUCCCAAGAAG	6714	ccAGAGcGuucccAAGAAGdTsdT	sense

522-541	6715	CUUCUUGGGAACGCUCUGG	6716	CUUCUUGGGAACGCUCUGGdTsdT	antis

526-545	6717	AGCGUUCCCAAGAAGUGGC	6718	AGcGuucccAAGAAGuGGcdTsdT	sense

526-545	6719	GCCACUUCUUGGGAACGCU	6720	GCcACUUCUUGGGAACGCUdTsdT	antis

700-719	6721	GCAAUAUUGUGAGGCUGCG	6722	GcAAuAuuGuGAGGcuGcGdTsdT	sense

700-719	6723	CGCAGCCUCACAAUAUUGC	6724	CGcAGCCUcAcAAuAUUGCdTsdT	antis

873-892	6725	CUCUUCCGGAGCUUGGCCU	6726	cucuuccGGAGcuuGGccudTsdT	sense

873-892	6727	AGGCCAAGCUCCGGAAGAG	6728	AGGCcAAGCUCCGGAAGAGdTsdT	antis

1256-1275	6729	GUUCCCCCAGAUCAAAGCU	6730	GuucccccAGAucAAAGcudTsdT	sense

1256-1275	6731	AGCUUUGAUCUGGGGGAAC	6732	AGCUUUGAUCUGGGGGAACdTsdT	antis

1317-1336	6733	GAGGCCAUUGCACUCUGCU	6734	GAGGccAuuGcAcucuGcudTsdT	sense

1317-1336	6735	AGCAGAGUGCAAUGGCCUC	6736	AGcAGAGUGcAAUGGCCUCdTsdT	antis

1512-1531	6737	CUCAUCCCUCCUCACUUGA	6738	cucAucccuccucAcuuGAdTsdT	sense

1512-1531	6739	UCAAGUGAGGAGGGAUGAG	6740	UcAAGUGAGGAGGGAUGAGdTsdT	antis

1764-1783	6741	AGACUAGAGGGCAGAGGUA	6742	AGAcuAGAGGGcAGAGGuAdTsdT	sense

1764-1783	6743	UACCUCUGCCCUCUAGUCU	6744	uACCUCUGCCCUCuAGUCUdTsdT	antis

236-255	6745	CCGGGCGCGGACCAGCUCG	6746	ccGGGcGcGGAccAGcucGdTsdT	sense

236-255	6747	CGAGCUGGUCCGCGCCCGG	6748	CGAGCUGGUCCGCGCCCGGdTsdT	antis

914-933	6749	UCACCGUGACAUCAAGCCC	6750	ucAccGuGAcAucAAGcccdTsdT	sense

914-933	6751	GGGCUUGAUGUCACGGUGA	6752	GGGCUUGAUGUcACGGUGAdTsdT	antis

234-253	6753	GGCCGGGCGCGGACCAGCU	6754	GGccGGGcGcGGAccAGcudTsdT	sense

234-253	6755	AGCUGGUCCGCGCCCGGCC	6756	AGCUGGUCCGCGCCCGGCCdTsdT	antis

520-539	6757	GCCCAGAGCGUUCCCAAGA	6758	GcccAGAGcGuucccAAGAdTsdT	sense

520-539	6759	UCUUGGGAACGCUCUGGGC	6760	UCUUGGGAACGCUCUGGGCdTsdT	antis

525-544	6761	GAGCGUUCCCAAGAAGUGG	6762	GAGcGuucccAAGAAGuGGdTsdT	sense

525-544	6763	CCACUUCUUGGGAACGCUC	6764	CcACUUCUUGGGAACGCUCdTsdT	antis

549-568	6765	ACUGACAUCAAAGUGAUUG	6766	AcuGAcAucAAAGuGAuuGdTsdT	sense

549-568	6767	CAAUCACUUUGAUGUCAGU	6768	cAAUcACUUUGAUGUcAGUdTsdT	antis

555-574	6769	AUCAAAGUGAUUGGUAAUG	6770	AucAAAGuGAuuGGuAAuGdTsdT	sense

555-574	6771	CAUUACCAAUCACUUUGAU	6772	cAUuACcAAUcACUUUGAUdTsdT	antis

558-577	6773	AAAGUGAUUGGUAAUGGCU	6774	AAAGuGAuuGGuAAuGGcudTsdT	sense

558-577	6775	AGCCAUUACCAAUCACUUU	6776	AGCcAUuACcAAUcACUUUdTsdT	antis

567-586	6777	GGUAAUGGCUCAUUCGGAG	6778	GGuAAuGGcucAuucGGAGdTsdT	sense

567-586	6779	CUCCGAAUGAGCCAUUACC	6780	CUCCGAAUGAGCcAUuACCdTsdT	antis

571-590	6781	AUGGCUCAUUCGGAGUAGU	6782	AuGGcucAuucGGAGuAGudTsdT	sense

571-590	6783	ACUACUCCGAAUGAGCCAU	6784	ACuACUCCGAAUGAGCcAUdTsdT	antis

685-704	6785	GUAAGCUGGACCACUGCAA	6786	GuAAGcuGGAccAcuGcAAdTsdT	sense

685-704	6787	UUGCAGUGGUCCAGCUUAC	6788	UUGcAGUGGUCcAGCUuACdTsdT	antis

764-783	6789	GAAUCUGGUGCUGGAGUAU	6790	GAAucuGGuGcuGGAGuAudTsdT	sense

764-783	6791	AUACUCCAGCACCAGAUUC	6792	AuACUCcAGcACcAGAUUCdTsdT	antis

777-796	6793	GAGUAUGUGCCCGAGACGG	6794	GAGuAuGuGcccGAGAcGGdTsdT	sense

777-796	6795	CCGUCUCGGGCACAUACUC	6796	CCGUCUCGGGcAcAuACUCdTsdT	antis

783-802	6797	GUGCCCGAGACGGUGUACC	6798	GuGcccGAGAcGGuGuAccdTsdT	sense

783-802	6799	GGUACACCGUCUCGGGCAC	6800	GGuAcACCGUCUCGGGcACdTsdT	antis

802-821	6801	GAGUGGCCCGCCACUUCAC	6802	GAGuGGcccGccAcuucAcdTsdT	sense

802-821	6803	GUGAAGUGGCGGGCCACUC	6804	GUGAAGUGGCGGGCcACUCdTsdT	antis

818-837	6805	CACCAAGGCCAAGCUGAUC	6806	cAccAAGGccAAGcuGAucdTsdT	sense

818-837	6807	GAUCAGCUUGGCCUUGGUG	6808	GAUcAGCUUGGCCUUGGUGdTsdT	antis

852-871	6809	AUCAAGGUGUACAUGUACC	6810	AucAAGGuGuAcAuGuAccdTsdT	sense

852-871	6811	GGUACAUGUACACCUUGAU	6812	GGuAcAUGuAcACCUUGAUdTsdT	antis

853-872	6813	UCAAGGUGUACAUGUACCA	6814	ucAAGGuGuAcAuGuAccAdTsdT	sense

853-872	6815	UGGUACAUGUACACCUUGA	6816	UGGuAcAUGuAcACCUUGAdTsdT	antis

937-956	6817	AUUUGCUUGUGGACCCUGA	6818	AuuuGcuuGuGGAcccuGAdTsdT	sense

937-956	6819	UCAGGGUCCACAAGCAAAU	6820	UcAGGGUCcAcAAGcAAAUdTsdT	antis

942-961	6821	CUUGUGGACCCUGACACUG	6822	cuuGuGGAcccuGAcAcuGdTsdT	sense

942-961	6823	CAGUGUCAGGGUCCACAAG	6824	cAGUGUcAGGGUCcAcAAGdTsdT	antis

967-986	6825	UCAAGCUCUGCGAUUUUGG	6826	ucAAGcucuGcGAuuuuGGdTsdT	sense

967-986	6827	CCAAAAUCGCAGAGCUUGA	6828	CcAAAAUCGcAGAGCUUGAdTsdT	antis

968-987	6829	CAAGCUCUGCGAUUUUGGC	6830	cAAGcucuGcGAuuuuGGcdTsdT	sense

968-987	6831	GCCAAAAUCGCAGAGCUUG	6832	GCcAAAAUCGcAGAGCUUGdTsdT	antis

976-995	6833	GCGAUUUUGGCAGUGCAAA	6834	GcGAuuuuGGcAGuGcAAAdTsdT	sense

976-995	6835	UUUGCACUGCCAAAAUCGC	6836	UUUGcACUGCcAAAAUCGCdTsdT	antis

984-1003	6837	GGCAGUGCAAAGCAGCUGG	6838	GGcAGuGcAAAGcAGcuGGdTsdT	sense

984-1003	6839	CCAGCUGCUUUGCACUGCC	6840	CcAGCUGCUUUGcACUGCCdTsdT	antis

1039-1058	6841	GGUACUACCGUGCUCCAGA	6842	GGuAcuAccGuGcuccAGAdTsdT	sense

1039-1058	6843	UCUGGAGCACGGUAGUACC	6844	UCUGGAGcACGGuAGuACCdTsdT	antis

1044-1063	6845	UACCGUGCUCCAGAACUCA	6846	uAccGuGcuccAGAAcucAdTsdT	sense

1044-1063	6847	UGAGUUCUGGAGCACGGUA	6848	UGAGUUCUGGAGcACGGuAdTsdT	antis

1185-1204	6849	AUCAUCAAGGUACUAGGAA	6850	AucAucAAGGuAcuAGGAAdTsdT	sense

1185-1204	6851	UUCCUAGUACCUUGAUGAU	6852	UUCCuAGuACCUUGAUGAUdTsdT	antis

1188-1207	6853	AUCAAGGUACUAGGAACGC	6854	AucAAGGuAcuAGGAAcGcdTsdT	sense

1188-1207	6855	GCGUUCCUAGUACCUUGAU	6856	GCGUUCCuAGuACCUUGAUdTsdT	antis

1196-1215	6857	ACUAGGAACGCCAACCAGG	6858	AcuAGGAAcGccAAccAGGdTsdT	sense

1196-1215	6859	CCUGGUUGGCGUUCCUAGU	6860	CCUGGUUGGCGUUCCuAGUdTsdT	antis

1204-1223	6861	CGCCAACCAGGGAACAAAU	6862	cGccAAccAGGGAAcAAAudTsdT	sense

1204-1223	6863	AUUUGUUCCCUGGUUGGCG	6864	AUUUGUUCCCUGGUUGGCGdTsdT	antis

1213-1232	6865	GGGAACAAAUCCGAGAGAU	6866	GGGAAcAAAuccGAGAGAudTsdT	sense

1213-1232	6867	AUCUCUCGGAUUUGUUCCC	6868	AUCUCUCGGAUUUGUUCCCdTsdT	antis

1215-1234	6869	GAACAAAUCCGAGAGAUGA	6870	GAAcAAAuccGAGAGAuGAdTsdT	sense

1215-1234	6871	UCAUCUCUCGGAUUUGUUC	6872	UcAUCUCUCGGAUUUGUUCdTsdT	antis

1216-1235	6873	AACAAAUCCGAGAGAUGAA	6874	AAcAAAuccGAGAGAuGAAdTsdT	sense

1216-1235	6875	UUCAUCUCUCGGAUUUGUU	6876	UUcAUCUCUCGGAUUUGUUdTsdT	antis

1217-1236	6877	ACAAAUCCGAGAGAUGAAC	6878	AcAAAuccGAGAGAuGAAcdTsdT	sense

1217-1236	6879	GUUCAUCUCUCGGAUUUGU	6880	GUUcAUCUCUCGGAUUUGUdTsdT	antis

1429-1448	6881	AGCUCCCCAACGACCGCCC	6882	AGcuccccAAcGAccGcccdTsdT	sense

1429-1448	6883	GGGCGGUCGUUGGGGAGCU	6884	GGGCGGUCGUUGGGGAGCUdTsdT	antis

1430-1449	6885	GCUCCCCAACGACCGCCCG	6886	GcuccccAAcGAccGcccGdTsdT	sense

1430-1449	6887	CGGGCGGUCGUUGGGGAGC	6888	CGGGCGGUCGUUGGGGAGCdTsdT	antis

1580-1599	6889	CUCACAAGCUUUAACUGAA	6890	cucAcAAGcuuuAAcuGAAdTsdT	sense

1580-1599	6891	UUCAGUUAAAGCUUGUGAG	6892	UUcAGUuAAAGCUUGUGAGdTsdT	antis

1667-1686	6893	GCCCCACCGACUACCCCUC	6894	GccccAccGAcuAccccucdTsdT	sense

1667-1686	6895	GAGGGGUAGUCGGUGGGGC	6896	GAGGGGuAGUCGGUGGGGCdTsdT	antis

1669-1688	6897	CCCACCGACUACCCCUCCA	6898	cccAccGAcuAccccuccAdTsdT	sense

1669-1688	6899	UGGAGGGGUAGUCGGUGGG	6900	UGGAGGGGuAGUCGGUGGGdTsdT	antis

1682-1701	6901	CCUCCACGUCCAUCUGGGA	6902	ccuccAcGuccAucuGGGAdTsdT	sense

1682-1701	6903	UCCCAGAUGGACGUGGAGG	6904	UCCcAGAUGGACGUGGAGGdTsdT	antis

1685-1704	6905	CCACGUCCAUCUGGGAAGG	6906	ccAcGuccAucuGGGAAGGdTsdT	sense

1685-1704	6907	CCUUCCCAGAUGGACGUGG	6908	CCUUCCcAGAUGGACGUGGdTsdT	antis

1704-1723	6909	CCCAAGUGGCGCUGGGAAG	6910	cccAAGuGGcGcuGGGAAGdTsdT	sense

1704-1723	6911	CUUCCCAGCGCCACUUGGG	6912	CUUCCcAGCGCcACUUGGGdTsdT	antis

1705-1724	6913	CCAAGUGGCGCUGGGAAGG	6914	ccAAGuGGcGcuGGGAAGGdTsdT	sense

1705-1724	6915	CCUUCCCAGCGCCACUUGG	6916	CCUUCCcAGCGCcACUUGGdTsdT	antis

1730-1749	6917	CAGCCCAUCAAGCUCCUGC	6918	cAGcccAucAAGcuccuGcdTsdT	sense

1730-1749	6919	GCAGGAGCUUGAUGGGCUG	6920	GcAGGAGCUUGAUGGGCUGdTsdT	antis

1753-1772	6921	GCUGGGCCCCUAGACUAGA	6922	GcuGGGccccuAGAcuAGAdTsdT	sense

1753-1772	6923	UCUAGUCUAGGGGCCCAGC	6924	UCuAGUCuAGGGGCCcAGCdTsdT	antis

1759-1778	6925	CCCCUAGACUAGAGGGCAG	6926	ccccuAGAcuAGAGGGcAGdTsdT	sense

1759-1778	6927	CUGCCCUCUAGUCUAGGGG	6928	CUGCCCUCuAGUCuAGGGGdTsdT	antis

1760-1779	6929	CCCUAGACUAGAGGGCAGA	6930	cccuAGAcuAGAGGGcAGAdTsdT	sense

1760-1779	6931	UCUGCCCUCUAGUCUAGGG	6932	UCUGCCCUCuAGUCuAGGGdTsdT	antis

1763-1782	6933	UAGACUAGAGGGCAGAGGU	6934	uAGAcuAGAGGGcAGAGGudTsdT	sense

1763-1782	6935	ACCUCUGCCCUCUAGUCUA	6936	ACCUCUGCCCUCuAGUCuAdTsdT	antis

1773-1792	6937	GGCAGAGGUAAAUGAACUA	6938	GGcAGAGGuAAAuGAAcuAdTsdT	sense

1773-1792	6939	UAGUUCAUUUACCUCUGCC	6940	uAGUUcAUUuACCUCUGCCdTsdT	antis

1774-1793	6941	GCAGAGGUAAAUGAACUAC	6942	GcAGAGGuAAAuGAAcuAcdTsdT	sense

1774-1793	6943	GUAGUUCAUUUACCUCUGC	6944	GuAGUUcAUUuACCUCUGCdTsdT	antis

1782-1801	6945	AAAUGAACUACCCCCAGCA	6946	AAAuGAAcuAcccccAGcAdTsdT	sense

1782-1801	6947	UGCUGGGGGUAGUUCAUUU	6948	UGCUGGGGGuAGUUcAUUUdTsdT	antis

1784-1803	6949	AUGAACUACCCCCAGCAUC	6950	AuGAAcuAcccccAGcAucdTsdT	sense

1784-1803	6951	GAUGCUGGGGGUAGUUCAU	6952	GAUGCUGGGGGuAGUUcAUdTsdT	antis

1785-1804	6953	UGAACUACCCCCAGCAUCU	6954	uGAAcuAcccccAGcAucudTsdT	sense

1785-1804	6955	AGAUGCUGGGGGUAGUUCA	6956	AGAUGCUGGGGGuAGUUcAdTsdT	antis

1790-1809	6957	UACCCCCAGCAUCUAGGCC	6958	uAcccccAGcAucuAGGccdTsdT	sense

1790-1809	6959	GGCCUAGAUGCUGGGGGUA	6960	GGCCuAGAUGCUGGGGGuAdTsdT	antis

1794-1813	6961	CCCAGCAUCUAGGCCUCCC	6962	cccAGcAucuAGGccucccdTsdT	sense

1794-1813	6963	GGGAGGCCUAGAUGCUGGG	6964	GGGAGGCCuAGAUGCUGGGdTsdT	antis

1795-1814	6965	CCAGCAUCUAGGCCUCCCU	6966	ccAGcAucuAGGccucccudTsdT	sense

1795-1814	6967	AGGGAGGCCUAGAUGCUGG	6968	AGGGAGGCCuAGAUGCUGGdTsdT	antis

1882-1901	6969	GGAAGGACGGGGUUUGGGG	6970	GGAAGGAcGGGGuuuGGGGdTsdT	sense

1882-1901	6971	CCCCAAACCCCGUCCUUCC	6972	CCCcAAACCCCGUCCUUCCdTsdT	antis

1883-1902	6973	GAAGGACGGGGUUUGGGGG	6974	GAAGGAcGGGGuuuGGGGGdTsdT	sense

1883-1902	6975	CCCCCAAACCCCGUCCUUC	6976	CCCCcAAACCCCGUCCUUCdTsdT	antis

1913-1932	6977	UCUACCCCCUUGGUCCCCU	6978	ucuAcccccuuGGuccccudTsdT	sense

1913-1932	6979	AGGGGACCAAGGGGGUAGA	6980	AGGGGACcAAGGGGGuAGAdTsdT	antis

68-87	6981	CGGAGCCGGAGCCCGAACG	6982	cGGAGccGGAGcccGAAcGdTsdT	sense

68-87	6983	CGUUCGGGCUCCGGCUCCG	6984	CGUUCGGGCUCCGGCUCCGdTsdT	antis

117-136	6985	GAGGCGGCGGCAGAGGCAG	6986	GAGGcGGcGGcAGAGGcAGdTsdT	sense

117-136	6987	CUGCCUCUGCCGCCGCCUC	6988	CUGCCUCUGCCGCCGCCUCdTsdT	antis

188-207	6989	CGCCAUGAGCGGCGGCGGG	6990	cGccAuGAGcGGcGGcGGGdTsdT	sense

188-207	6991	CCCGCCGCCGCUCAUGGCG	6992	CCCGCCGCCGCUcAUGGCGdTsdT	antis

219-238	6993	GGCCCUGGGGGCUCGGGCC	6994	GGcccuGGGGGcucGGGccdTsdT	sense

219-238	6995	GGCCCGAGCCCCCAGGGCC	6996	GGCCCGAGCCCCcAGGGCCdTsdT	antis

220-239	6997	GCCCUGGGGGCUCGGGCCG	6998	GcccuGGGGGcucGGGccGdTsdT	sense

220-239	6999	CGGCCCGAGCCCCCAGGGC	7000	CGGCCCGAGCCCCcAGGGCdTsdT	antis

233-252	7001	GGGCCGGGCGCGGACCAGC	7002	GGGccGGGcGcGGAccAGcdTsdT	sense

233-252	7003	GCUGGUCCGCGCCCGGCCC	7004	GCUGGUCCGCGCCCGGCCCdTsdT	antis

237-256	7005	CGGGCGCGGACCAGCUCGU	7006	cGGGcGcGGAccAGcucGudTsdT	sense

237-256	7007	ACGAGCUGGUCCGCGCCCG	7008	ACGAGCUGGUCCGCGCCCGdTsdT	antis

308-327	7009	GGCCUCUGGCCCAGGAGGC	7010	GGccucuGGcccAGGAGGcdTsdT	sense

308-327	7011	GCCUCCUGGGCCAGAGGCC	7012	GCCUCCUGGGCcAGAGGCCdTsdT	antis

311-330	7013	CUCUGGCCCAGGAGGCACU	7014	cucuGGcccAGGAGGcAcudTsdT	sense

311-330	7015	AGUGCCUCCUGGGCCAGAG	7016	AGUGCCUCCUGGGCcAGAGdTsdT	antis

351-370	7017	GGGGCUAUGGGUGGGGGCG	7018	GGGGcuAuGGGuGGGGGcGdTsdT	sense

351-370	7019	CGCCCCCACCCAUAGCCCC	7020	CGCCCCcACCcAuAGCCCCdTsdT	antis

353-372	7021	GGCUAUGGGUGGGGGCGUG	7022	GGcuAuGGGuGGGGGcGuGdTsdT	sense

353-372	7023	CACGCCCCCACCCAUAGCC	7024	cACGCCCCcACCcAuAGCCdTsdT	antis

355-374	7025	CUAUGGGUGGGGGCGUGGG	7026	cuAuGGGuGGGGGcGuGGGdTsdT	sense

355-374	7027	CCCACGCCCCCACCCAUAG	7028	CCcACGCCCCcACCcAuAGdTsdT	antis

357-376	7029	AUGGGUGGGGGCGUGGGAG	7030	AuGGGuGGGGGcGuGGGAGdTsdT	sense

357-376	7031	CUCCCACGCCCCCACCCAU	7032	CUCCcACGCCCCcACCcAUdTsdT	antis

361-380	7033	GUGGGGGCGUGGGAGCCUC	7034	GuGGGGGcGuGGGAGccucdTsdT	sense

361-380	7035	GAGGCUCCCACGCCCCCAC	7036	GAGGCUCCcACGCCCCcACdTsdT	antis

363-382	7037	GGGGGCGUGGGAGCCUCGA	7038	GGGGGcGuGGGAGccucGAdTsdT	sense

363-382	7039	UCGAGGCUCCCACGCCCCC	7040	UCGAGGCUCCcACGCCCCCdTsdT	antis

364-383	7041	GGGGCGUGGGAGCCUCGAG	7042	GGGGcGuGGGAGccucGAGdTsdT	sense

364-383	7043	CUCGAGGCUCCCACGCCCC	7044	CUCGAGGCUCCcACGCCCCdTsdT	antis

365-384	7045	GGGCGUGGGAGCCUCGAGC	7046	GGGcGuGGGAGccucGAGcdTsdT	sense

365-384	7047	GCUCGAGGCUCCCACGCCC	7048	GCUCGAGGCUCCcACGCCCdTsdT	antis

366-385	7049	GGCGUGGGAGCCUCGAGCU	7050	GGcGuGGGAGccucGAGcudTsdT	sense

366-385	7051	AGCUCGAGGCUCCCACGCC	7052	AGCUCGAGGCUCCcACGCCdTsdT	antis

368-387	7053	CGUGGGAGCCUCGAGCUCC	7054	cGuGGGAGccucGAGcuccdTsdT	sense

368-387	7055	GGAGCUCGAGGCUCCCACG	7056	GGAGCUCGAGGCUCCcACGdTsdT	antis

485-504	7057	GAAGGUGACCACAGUGGUA	7058	GAAGGuGAccAcAGuGGuAdTsdT	sense

485-504	7059	UACCACUGUGGUCACCUUC	7060	uACcACUGUGGUcACCUUCdTsdT	antis

487-506	7061	AGGUGACCACAGUGGUAGC	7062	AGGuGAccAcAGuGGuAGcdTsdT	sense

487-506	7063	GCUACCACUGUGGUCACCU	7064	GCuACcACUGUGGUcACCUdTsdT	antis

488-507	7065	GGUGACCACAGUGGUAGCC	7066	GGuGAccAcAGuGGuAGccdTsdT	sense

488-507	7067	GGCUACCACUGUGGUCACC	7068	GGCuACcACUGUGGUcACCdTsdT	antis

547-566	7069	ACACUGACAUCAAAGUGAU	7070	AcAcuGAcAucAAAGuGAudTsdT	sense

547-566	7071	AUCACUUUGAUGUCAGUGU	7072	AUcACUUUGAUGUcAGUGUdTsdT	antis

548-567	7073	CACUGACAUCAAAGUGAUU	7074	cAcuGAcAucAAAGuGAuudTsdT	sense

548-567	7075	AAUCACUUUGAUGUCAGUG	7076	AAUcACUUUGAUGUcAGUGdTsdT	antis

551-570	7077	UGACAUCAAAGUGAUUGGU	7078	uGAcAucAAAGuGAuuGGudTsdT	sense

551-570	7079	ACCAAUCACUUUGAUGUCA	7080	ACcAAUcACUUUGAUGUcAdTsdT	antis

552-571	7081	GACAUCAAAGUGAUUGGUA	7082	GAcAucAAAGuGAuuGGuAdTsdT	sense

552-571	7083	UACCAAUCACUUUGAUGUC	7084	uACcAAUcACUUUGAUGUCdTsdT	antis

553-572	7085	ACAUCAAAGUGAUUGGUAA	7086	AcAucAAAGuGAuuGGuAAdTsdT	sense

553-572	7087	UUACCAAUCACUUUGAUGU	7088	UuACcAAUcACUUUGAUGUdTsdT	antis

554-573	7089	CAUCAAAGUGAUUGGUAAU	7090	cAucAAAGuGAuuGGuAAudTsdT	sense

554-573	7091	AUUACCAAUCACUUUGAUG	7092	AUuACcAAUcACUUUGAUGdTsdT	antis

556-575	7093	UCAAAGUGAUUGGUAAUGG	7094	ucAAAGuGAuuGGuAAuGGdTsdT	sense

556-575	7095	CCAUUACCAAUCACUUUGA	7096	CcAUuACcAAUcACUUUGAdTsdT	antis

557-576	7097	CAAAGUGAUUGGUAAUGGC	7098	cAAAGuGAuuGGuAAuGGcdTsdT	sense

557-576	7099	GCCAUUACCAAUCACUUUG	7100	GCcAUuACcAAUcACUUUGdTsdT	antis

562-581	7101	UGAUUGGUAAUGGCUCAUU	7102	uGAuuGGuAAuGGcucAuudTsdT	sense

562-581	7103	AAUGAGCCAUUACCAAUCA	7104	AAUGAGCcAUuACcAAUcAdTsdT	antis

563-582	7105	GAUUGGUAAUGGCUCAUUC	7106	GAuuGGuAAuGGcucAuucdTsdT	sense

563-582	7107	GAAUGAGCCAUUACCAAUC	7108	GAAUGAGCcAUuACcAAUCdTsdT	antis

564-583	7109	AUUGGUAAUGGCUCAUUCG	7110	AuuGGuAAuGGcucAuucGdTsdT	sense

564-583	7111	CGAAUGAGCCAUUACCAAU	7112	CGAAUGAGCcAUuACcAAUdTsdT	antis

565-584	7113	UUGGUAAUGGCUCAUUCGG	7114	uuGGuAAuGGcucAuucGGdTsdT	sense

565-584	7115	CCGAAUGAGCCAUUACCAA	7116	CCGAAUGAGCcAUuACcAAdTsdT	antis

566-585	7117	UGGUAAUGGCUCAUUCGGA	7118	uGGuAAuGGcucAuucGGAdTsdT	sense

566-585	7119	UCCGAAUGAGCCAUUACCA	7120	UCCGAAUGAGCcAUuACcAdTsdT	antis

627-646	7121	GCCAUCAAGAAGGUUCUUC	7122	GccAucAAGAAGGuucuucdTsdT	sense

627-646	7123	GAAGAACCUUCUUGAUGGC	7124	GAAGAACCUUCUUGAUGGCdTsdT	antis

631-650	7125	UCAAGAAGGUUCUUCAGGA	7126	ucAAGAAGGuucuucAGGAdTsdT	sense

631-650	7127	UCCUGAAGAACCUUCUUGA	7128	UCCUGAAGAACCUUCUUGAdTsdT	antis

632-651	7129	CAAGAAGGUUCUUCAGGAC	7130	cAAGAAGGuucuucAGGAcdTsdT	sense

632-651	7131	GUCCUGAAGAACCUUCUUG	7132	GUCCUGAAGAACCUUCUUGdTsdT	antis

634-653	7133	AGAAGGUUCUUCAGGACAA	7134	AGAAGGuucuucAGGAcAAdTsdT	sense

634-653	7135	UUGUCCUGAAGAACCUUCU	7136	UUGUCCUGAAGAACCUUCUdTsdT	antis

635-654	7137	GAAGGUUCUUCAGGACAAA	7138	GAAGGuucuucAGGAcAAAdTsdT	sense

635-654	7139	UUUGUCCUGAAGAACCUUC	7140	UUUGUCCUGAAGAACCUUCdTsdT	antis

638-657	7141	GGUUCUUCAGGACAAAAGG	7142	GGuucuucAGGAcAAAAGGdTsdT	sense

638-657	7143	CCUUUUGUCCUGAAGAACC	7144	CCUUUUGUCCUGAAGAACCdTsdT	antis

639-658	7145	GUUCUUCAGGACAAAAGGU	7146	GuucuucAGGAcAAAAGGudTsdT	sense

639-658	7147	ACCUUUUGUCCUGAAGAAC	7148	ACCUUUUGUCCUGAAGAACdTsdT	antis

640-659	7149	UUCUUCAGGACAAAAGGUU	7150	uucuucAGGAcAAAAGGuudTsdT	sense

640-659	7151	AACCUUUUGUCCUGAAGAA	7152	AACCUUUUGUCCUGAAGAAdTsdT	antis

641-660	7153	UCUUCAGGACAAAAGGUUC	7154	ucuucAGGAcAAAAGGuucdTsdT	sense

641-660	7155	GAACCUUUUGUCCUGAAGA	7156	GAACCUUUUGUCCUGAAGAdTsdT	antis

642-661	7157	CUUCAGGACAAAAGGUUCA	7158	cuucAGGAcAAAAGGuucAdTsdT	sense

642-661	7159	UGAACCUUUUGUCCUGAAG	7160	UGAACCUUUUGUCCUGAAGdTsdT	antis

643-662	7161	UUCAGGACAAAAGGUUCAA	7162	uucAGGAcAAAAGGuucAAdTsdT	sense

643-662	7163	UUGAACCUUUUGUCCUGAA	7164	UUGAACCUUUUGUCCUGAAdTsdT	antis

644-663	7165	UCAGGACAAAAGGUUCAAG	7166	ucAGGAcAAAAGGuucAAGdTsdT	sense

644-663	7167	CUUGAACCUUUUGUCCUGA	7168	CUUGAACCUUUUGUCCUGAdTsdT	antis

645-664	7169	CAGGACAAAAGGUUCAAGA	7170	cAGGAcAAAAGGuucAAGAdTsdT	sense

645-664	7171	UCUUGAACCUUUUGUCCUG	7172	UCUUGAACCUUUUGUCCUGdTsdT	antis

686-705	7173	UAAGCUGGACCACUGCAAU	7174	uAAGcuGGAccAcuGcAAudTsdT	sense

686-705	7175	AUUGCAGUGGUCCAGCUUA	7176	AUUGcAGUGGUCcAGCUuAdTsdT	antis

687-706	7177	AAGCUGGACCACUGCAAUA	7178	AAGcuGGAccAcuGcAAuAdTsdT	sense

687-706	7179	UAUUGCAGUGGUCCAGCUU	7180	uAUUGcAGUGGUCcAGCUUdTsdT	antis

689-708	7181	GCUGGACCACUGCAAUAUU	7182	GcuGGAccAcuGcAAuAuudTsdT	sense

689-708	7183	AAUAUUGCAGUGGUCCAGC	7184	AAuAUUGcAGUGGUCcAGCdTsdT	antis

690-709	7185	CUGGACCACUGCAAUAUUG	7186	cuGGAccAcuGcAAuAuuGdTsdT	sense

690-709	7187	CAAUAUUGCAGUGGUCCAG	7188	cAAuAUUGcAGUGGUCcAGdTsdT	antis

691-710	7189	UGGACCACUGCAAUAUUGU	7190	uGGAccAcuGcAAuAuuGudTsdT	sense

691-710	7191	ACAAUAUUGCAGUGGUCCA	7192	AcAAuAUUGcAGUGGUCcAdTsdT	antis

692-711	7193	GGACCACUGCAAUAUUGUG	7194	GGAccAcuGcAAuAuuGuGdTsdT	sense

692-711	7195	CACAAUAUUGCAGUGGUCC	7196	cAcAAuAUUGcAGUGGUCCdTsdT	antis

694-713	7197	ACCACUGCAAUAUUGUGAG	7198	AccAcuGcAAuAuuGuGAGdTsdT	sense

694-713	7199	CUCACAAUAUUGCAGUGGU	7200	CUcAcAAuAUUGcAGUGGUdTsdT	antis

696-715	7201	CACUGCAAUAUUGUGAGGC	7202	cAcuGcAAuAuuGuGAGGcdTsdT	sense

696-715	7203	GCCUCACAAUAUUGCAGUG	7204	GCCUcAcAAuAUUGcAGUGdTsdT	antis

698-717	7205	CUGCAAUAUUGUGAGGCUG	7206	cuGcAAuAuuGuGAGGcuGdTsdT	sense

698-717	7207	CAGCCUCACAAUAUUGCAG	7208	cAGCCUcAcAAuAUUGcAGdTsdT	antis

699-718	7209	UGCAAUAUUGUGAGGCUGC	7210	uGcAAuAuuGuGAGGcuGcdTsdT	sense

699-718	7211	GCAGCCUCACAAUAUUGCA	7212	GcAGCCUcAcAAuAUUGcAdTsdT	antis

718-737	7213	GGUACUUUUUCUACUCCAG	7214	GGuAcuuuuucuAcuccAGdTsdT	sense

718-737	7215	CUGGAGUAGAAAAAGUACC	7216	CUGGAGuAGAAAAAGuACCdTsdT	antis

720-739	7217	UACUUUUUCUACUCCAGUG	7218	uAcuuuuucuAcuccAGuGdTsdT	sense

720-739	7219	CACUGGAGUAGAAAAAGUA	7220	cACUGGAGuAGAAAAAGuAdTsdT	antis

721-740	7221	ACUUUUUCUACUCCAGUGG	7222	AcuuuuucuAcuccAGuGGdTsdT	sense

721-740	7223	CCACUGGAGUAGAAAAAGU	7224	CcACUGGAGuAGAAAAAGUdTsdT	antis

723-742	7225	UUUUUCUACUCCAGUGGGG	7226	uuuuucuAcuccAGuGGGGdTsdT	sense

723-742	7227	CCCCACUGGAGUAGAAAAA	7228	CCCcACUGGAGuAGAAAAAdTsdT	antis

729-748	7229	UACUCCAGUGGGGAGAAGA	7230	uAcuccAGuGGGGAGAAGAdTsdT	sense

729-748	7231	UCUUCUCCCCACUGGAGUA	7232	UCUUCUCCCcACUGGAGuAdTsdT	antis

730-749	7233	ACUCCAGUGGGGAGAAGAA	7234	AcuccAGuGGGGAGAAGAAdTsdT	sense

730-749	7235	UUCUUCUCCCCACUGGAGU	7236	UUCUUCUCCCcACUGGAGUdTsdT	antis

736-755	7237	GUGGGGAGAAGAAGGACGA	7238	GuGGGGAGAAGAAGGAcGAdTsdT	sense

736-755	7239	UCGUCCUUCUUCUCCCCAC	7240	UCGUCCUUCUUCUCCCcACdTsdT	antis

737-756	7241	UGGGGAGAAGAAGGACGAG	7242	uGGGGAGAAGAAGGAcGAGdTsdT	sense

737-756	7243	CUCGUCCUUCUUCUCCCCA	7244	CUCGUCCUUCUUCUCCCcAdTsdT	antis

755-774	7245	GCUGUAUUUGAAUCUGGUG	7246	GcuGuAuuuGAAucuGGuGdTsdT	sense

755-774	7247	CACCAGAUUCAAAUACAGC	7248	cACcAGAUUcAAAuAcAGCdTsdT	antis

756-775	7249	CUGUAUUUGAAUCUGGUGC	7250	cuGuAuuuGAAucuGGuGcdTsdT	sense

756-775	7251	GCACCAGAUUCAAAUACAG	7252	GcACcAGAUUcAAAuAcAGdTsdT	antis

758-777	7253	GUAUUUGAAUCUGGUGCUG	7254	GuAuuuGAAucuGGuGcuGdTsdT	sense

758-777	7255	CAGCACCAGAUUCAAAUAC	7256	cAGcACcAGAUUcAAAuACdTsdT	antis

761-780	7257	UUUGAAUCUGGUGCUGGAG	7258	uuuGAAucuGGuGcuGGAGdTsdT	sense

761-780	7259	CUCCAGCACCAGAUUCAAA	7260	CUCcAGcACcAGAUUcAAAdTsdT	antis

765-784	7261	AAUCUGGUGCUGGAGUAUG	7262	AAucuGGuGcuGGAGuAuGdTsdT	sense

765-784	7263	CAUACUCCAGCACCAGAUU	7264	cAuACUCcAGcACcAGAUUdTsdT	antis

769-788	7265	UGGUGCUGGAGUAUGUGCC	7266	uGGuGcuGGAGuAuGuGccdTsdT	sense

769-788	7267	GGCACAUACUCCAGCACCA	7268	GGcAcAuACUCcAGcACcAdTsdT	antis

770-789	7269	GGUGCUGGAGUAUGUGCCC	7270	GGuGcuGGAGuAuGuGcccdTsdT	sense

770-789	7271	GGGCACAUACUCCAGCACC	7272	GGGcAcAuACUCcAGcACCdTsdT	antis

771-790	7273	GUGCUGGAGUAUGUGCCCG	7274	GuGcuGGAGuAuGuGcccGdTsdT	sense

771-790	7275	CGGGCACAUACUCCAGCAC	7276	CGGGcAcAuACUCcAGcACdTsdT	antis

772-791	7277	UGCUGGAGUAUGUGCCCGA	7278	uGcuGGAGuAuGuGcccGAdTsdT	sense

772-791	7279	UCGGGCACAUACUCCAGCA	7280	UCGGGcAcAuACUCcAGcAdTsdT	antis

773-792	7281	GCUGGAGUAUGUGCCCGAG	7282	GcuGGAGuAuGuGcccGAGdTsdT	sense

773-792	7283	CUCGGGCACAUACUCCAGC	7284	CUCGGGcAcAuACUCcAGCdTsdT	antis

774-793	7285	CUGGAGUAUGUGCCCGAGA	7286	cuGGAGuAuGuGcccGAGAdTsdT	sense

774-793	7287	UCUCGGGCACAUACUCCAG	7288	UCUCGGGcAcAuACUCcAGdTsdT	antis

781-800	7289	AUGUGCCCGAGACGGUGUA	7290	AuGuGcccGAGAcGGuGuAdTsdT	sense

781-800	7291	UACACCGUCUCGGGCACAU	7292	uAcACCGUCUCGGGcAcAUdTsdT	antis

782-801	7293	UGUGCCCGAGACGGUGUAC	7294	uGuGcccGAGAcGGuGuAcdTsdT	sense

782-801	7295	GUACACCGUCUCGGGCACA	7296	GuAcACCGUCUCGGGcAcAdTsdT	antis

803-822	7297	AGUGGCCCGCCACUUCACC	7298	AGuGGcccGccAcuucAccdTsdT	sense

803-822	7299	GGUGAAGUGGCGGGCCACU	7300	GGUGAAGUGGCGGGCcACUdTsdT	antis

804-823	7301	GUGGCCCGCCACUUCACCA	7302	GuGGcccGccAcuucAccAdTsdT	sense

804-823	7303	UGGUGAAGUGGCGGGCCAC	7304	UGGUGAAGUGGCGGGCcACdTsdT	antis

805-824	7305	UGGCCCGCCACUUCACCAA	7306	uGGcccGccAcuucAccAAdTsdT	sense

805-824	7307	UUGGUGAAGUGGCGGGCCA	7308	UUGGUGAAGUGGCGGGCcAdTsdT	antis

806-825	7309	GGCCCGCCACUUCACCAAG	7310	GGcccGccAcuucAccAAGdTsdT	sense

806-825	7311	CUUGGUGAAGUGGCGGGCC	7312	CUUGGUGAAGUGGCGGGCCdTsdT	antis

807-826	7313	GCCCGCCACUUCACCAAGG	7314	GcccGccAcuucAccAAGGdTsdT	sense

807-826	7315	CCUUGGUGAAGUGGCGGGC	7316	CCUUGGUGAAGUGGCGGGCdTsdT	antis

808-827	7317	CCCGCCACUUCACCAAGGC	7318	cccGccAcuucAccAAGGcdTsdT	sense

808-827	7319	GCCUUGGUGAAGUGGCGGG	7320	GCCUUGGUGAAGUGGCGGGdTsdT	antis

809-828	7321	CCGCCACUUCACCAAGGCC	7322	ccGccAcuucAccAAGGccdTsdT	sense

809-828	7323	GGCCUUGGUGAAGUGGCGG	7324	GGCCUUGGUGAAGUGGCGGdTsdT	antis

810-829	7325	CGCCACUUCACCAAGGCCA	7326	cGccAcuucAccAAGGccAdTsdT	sense

810-829	7327	UGGCCUUGGUGAAGUGGCG	7328	UGGCCUUGGUGAAGUGGCGdTsdT	antis

811-830	7329	GCCACUUCACCAAGGCCAA	7330	GccAcuucAccAAGGccAAdTsdT	sense

811-830	7331	UUGGCCUUGGUGAAGUGGC	7332	UUGGCCUUGGUGAAGUGGCdTsdT	antis

813-832	7333	CACUUCACCAAGGCCAAGC	7334	cAcuucAccAAGGccAAGcdTsdT	sense

813-832	7335	GCUUGGCCUUGGUGAAGUG	7336	GCUUGGCCUUGGUGAAGUGdTsdT	antis

815-834	7337	CUUCACCAAGGCCAAGCUG	7338	cuucAccAAGGccAAGcuGdTsdT	sense

815-834	7339	CAGCUUGGCCUUGGUGAAG	7340	cAGCUUGGCCUUGGUGAAGdTsdT	antis

817-836	7341	UCACCAAGGCCAAGCUGAU	7342	ucAccAAGGccAAGcuGAudTsdT	sense

817-836	7343	AUCAGCUUGGCCUUGGUGA	7344	AUcAGCUUGGCCUUGGUGAdTsdT	antis

858-877	7345	GUGUACAUGUACCAGCUCU	7346	GuGuAcAuGuAccAGcucudTsdT	sense

858-877	7347	AGAGCUGGUACAUGUACAC	7348	AGAGCUGGuAcAUGuAcACdTsdT	antis

860-879	7349	GUACAUGUACCAGCUCUUC	7350	GuAcAuGuAccAGcucuucdTsdT	sense

860-879	7351	GAAGAGCUGGUACAUGUAC	7352	GAAGAGCUGGuAcAUGuACdTsdT	antis

861-880	7353	UACAUGUACCAGCUCUUCC	7354	uAcAuGuAccAGcucuuccdTsdT	sense

861-880	7355	GGAAGAGCUGGUACAUGUA	7356	GGAAGAGCUGGuAcAUGuAdTsdT	antis

862-881	7357	ACAUGUACCAGCUCUUCCG	7358	AcAuGuAccAGcucuuccGdTsdT	sense

862-881	7359	CGGAAGAGCUGGUACAUGU	7360	CGGAAGAGCUGGuAcAUGUdTsdT	antis

863-882	7361	CAUGUACCAGCUCUUCCGG	7362	cAuGuAccAGcucuuccGGdTsdT	sense

863-882	7363	CCGGAAGAGCUGGUACAUG	7364	CCGGAAGAGCUGGuAcAUGdTsdT	antis

865-884	7365	UGUACCAGCUCUUCCGGAG	7366	uGuAccAGcucuuccGGAGdTsdT	sense

865-884	7367	CUCCGGAAGAGCUGGUACA	7368	CUCCGGAAGAGCUGGuAcAdTsdT	antis

866-885	7369	GUACCAGCUCUUCCGGAGC	7370	GuAccAGcucuuccGGAGcdTsdT	sense

866-885	7371	GCUCCGGAAGAGCUGGUAC	7372	GCUCCGGAAGAGCUGGuACdTsdT	antis

867-886	7373	UACCAGCUCUUCCGGAGCU	7374	uAccAGcucuuccGGAGcudTsdT	sense

867-886	7375	AGCUCCGGAAGAGCUGGUA	7376	AGCUCCGGAAGAGCUGGuAdTsdT	antis

868-887	7377	ACCAGCUCUUCCGGAGCUU	7378	AccAGcucuuccGGAGcuudTsdT	sense

868-887	7379	AAGCUCCGGAAGAGCUGGU	7380	AAGCUCCGGAAGAGCUGGUdTsdT	antis

869-888	7381	CCAGCUCUUCCGGAGCUUG	7382	ccAGcucuuccGGAGcuuGdTsdT	sense

869-888	7383	CAAGCUCCGGAAGAGCUGG	7384	cAAGCUCCGGAAGAGCUGGdTsdT	antis

870-889	7385	CAGCUCUUCCGGAGCUUGG	7386	cAGcucuuccGGAGcuuGGdTsdT	sense

870-889	7387	CCAAGCUCCGGAAGAGCUG	7388	CcAAGCUCCGGAAGAGCUGdTsdT	antis

871-890	7389	AGCUCUUCCGGAGCUUGGC	7390	AGcucuuccGGAGcuuGGcdTsdT	sense

871-890	7391	GCCAAGCUCCGGAAGAGCU	7392	GCcAAGCUCCGGAAGAGCUdTsdT	antis

872-891	7393	GCUCUUCCGGAGCUUGGCC	7394	GcucuuccGGAGcuuGGccdTsdT	sense

872-891	7395	GGCCAAGCUCCGGAAGAGC	7396	GGCcAAGCUCCGGAAGAGCdTsdT	antis

874-893	7397	UCUUCCGGAGCUUGGCCUA	7398	ucuuccGGAGcuuGGccuAdTsdT	sense

874-893	7399	UAGGCCAAGCUCCGGAAGA	7400	uAGGCcAAGCUCCGGAAGAdTsdT	antis

876-895	7401	UUCCGGAGCUUGGCCUACA	7402	uuccGGAGcuuGGccuAcAdTsdT	sense

876-895	7403	UGUAGGCCAAGCUCCGGAA	7404	UGuAGGCcAAGCUCCGGAAdTsdT	antis

877-896	7405	UCCGGAGCUUGGCCUACAU	7406	uccGGAGcuuGGccuAcAudTsdT	sense

877-896	7407	AUGUAGGCCAAGCUCCGGA	7408	AUGuAGGCcAAGCUCCGGAdTsdT	antis

878-897	7409	CCGGAGCUUGGCCUACAUC	7410	ccGGAGcuuGGccuAcAucdTsdT	sense

878-897	7411	GAUGUAGGCCAAGCUCCGG	7412	GAUGuAGGCcAAGCUCCGGdTsdT	antis

911-930	7413	GUGUCACCGUGACAUCAAG	7414	GuGucAccGuGAcAucAAGdTsdT	sense

911-930	7415	CUUGAUGUCACGGUGACAC	7416	CUUGAUGUcACGGUGAcACdTsdT	antis

935-954	7417	GAAUUUGCUUGUGGACCCU	7418	GAAuuuGcuuGuGGAcccudTsdT	sense

935-954	7419	AGGGUCCACAAGCAAAUUC	7420	AGGGUCcAcAAGcAAAUUCdTsdT	antis

939-958	7421	UUGCUUGUGGACCCUGACA	7422	uuGcuuGuGGAcccuGAcAdTsdT	sense

939-958	7423	UGUCAGGGUCCACAAGCAA	7424	UGUcAGGGUCcAcAAGcAAdTsdT	antis

940-959	7425	UGCUUGUGGACCCUGACAC	7426	uGcuuGuGGAcccuGAcAcdTsdT	sense

940-959	7427	GUGUCAGGGUCCACAAGCA	7428	GUGUcAGGGUCcAcAAGcAdTsdT	antis

941-960	7429	GCUUGUGGACCCUGACACU	7430	GcuuGuGGAcccuGAcAcudTsdT	sense

941-960	7431	AGUGUCAGGGUCCACAAGC	7432	AGUGUcAGGGUCcAcAAGCdTsdT	antis

943-962	7433	UUGUGGACCCUGACACUGC	7434	uuGuGGAcccuGAcAcuGcdTsdT	sense

943-962	7435	GCAGUGUCAGGGUCCACAA	7436	GcAGUGUcAGGGUCcAcAAdTsdT	antis

949-968	7437	ACCCUGACACUGCUGUCCU	7438	AcccuGAcAcuGcuGuccudTsdT	sense

949-968	7439	AGGACAGCAGUGUCAGGGU	7440	AGGAcAGcAGUGUcAGGGUdTsdT	antis

952-971	7441	CUGACACUGCUGUCCUCAA	7442	cuGAcAcuGcuGuccucAAdTsdT	sense

952-971	7443	UUGAGGACAGCAGUGUCAG	7444	UUGAGGAcAGcAGUGUcAGdTsdT	antis

970-989	7445	AGCUCUGCGAUUUUGGCAG	7446	AGcucuGcGAuuuuGGcAGdTsdT	sense

970-989	7447	CUGCCAAAAUCGCAGAGCU	7448	CUGCcAAAAUCGcAGAGCUdTsdT	antis

974-993	7449	CUGCGAUUUUGGCAGUGCA	7450	cuGcGAuuuuGGcAGuGcAdTsdT	sense

974-993	7451	UGCACUGCCAAAAUCGCAG	7452	UGcACUGCcAAAAUCGcAGdTsdT	antis

977-996	7453	CGAUUUUGGCAGUGCAAAG	7454	cGAuuuuGGcAGuGcAAAGdTsdT	sense

977-996	7455	CUUUGCACUGCCAAAAUCG	7456	CUUUGcACUGCcAAAAUCGdTsdT	antis

978-997	7457	GAUUUUGGCAGUGCAAAGC	7458	GAuuuuGGcAGuGcAAAGcdTsdT	sense

978-997	7459	GCUUUGCACUGCCAAAAUC	7460	GCUUUGcACUGCcAAAAUCdTsdT	antis

986-1005	7461	CAGUGCAAAGCAGCUGGUU	7462	cAGuGcAAAGcAGcuGGuudTsdT	sense

986-1005	7463	AACCAGCUGCUUUGCACUG	7464	AACcAGCUGCUUUGcACUGdTsdT	antis

987-1006	7465	AGUGCAAAGCAGCUGGUUC	7466	AGuGcAAAGcAGcuGGuucdTsdT	sense

987-1006	7467	GAACCAGCUGCUUUGCACU	7468	GAACcAGCUGCUUUGcACUdTsdT	antis

988-1007	7469	GUGCAAAGCAGCUGGUUCG	7470	GuGcAAAGcAGcuGGuucGdTsdT	sense

988-1007	7471	CGAACCAGCUGCUUUGCAC	7472	CGAACcAGCUGCUUUGcACdTsdT	antis

1162-1181	7473	GUGGGGUGGACCAGCUUGU	7474	GuGGGGuGGAccAGcuuGudTsdT	sense

1162-1181	7475	ACAAGCUGGUCCACCCCAC	7476	AcAAGCUGGUCcACCCcACdTsdT	antis

1163-1182	7477	UGGGGUGGACCAGCUUGUG	7478	uGGGGuGGAccAGcuuGuGdTsdT	sense

1163-1182	7479	CACAAGCUGGUCCACCCCA	7480	cAcAAGCUGGUCcACCCcAdTsdT	antis

1164-1183	7481	GGGGUGGACCAGCUUGUGG	7482	GGGGuGGAccAGcuuGuGGdTsdT	sense

1164-1183	7483	CCACAAGCUGGUCCACCCC	7484	CcAcAAGCUGGUCcACCCCdTsdT	antis

1165-1184	7485	GGGUGGACCAGCUUGUGGA	7486	GGGuGGAccAGcuuGuGGAdTsdT	sense

1165-1184	7487	UCCACAAGCUGGUCCACCC	7488	UCcAcAAGCUGGUCcACCCdTsdT	antis

1168-1187	7489	UGGACCAGCUUGUGGAGAU	7490	uGGAccAGcuuGuGGAGAudTsdT	sense

1168-1187	7491	AUCUCCACAAGCUGGUCCA	7492	AUCUCcAcAAGCUGGUCcAdTsdT	antis

1172-1191	7493	CCAGCUUGUGGAGAUCAUC	7494	ccAGcuuGuGGAGAucAucdTsdT	sense

1172-1191	7495	GAUGAUCUCCACAAGCUGG	7496	GAUGAUCUCcAcAAGCUGGdTsdT	antis

1173-1192	7497	CAGCUUGUGGAGAUCAUCA	7498	cAGcuuGuGGAGAucAucAdTsdT	sense

1173-1192	7499	UGAUGAUCUCCACAAGCUG	7500	UGAUGAUCUCcAcAAGCUGdTsdT	antis

1175-1194	7501	GCUUGUGGAGAUCAUCAAG	7502	GcuuGuGGAGAucAucAAGdTsdT	sense

1175-1194	7503	CUUGAUGAUCUCCACAAGC	7504	CUUGAUGAUCUCcAcAAGCdTsdT	antis

1176-1195	7505	CUUGUGGAGAUCAUCAAGG	7506	cuuGuGGAGAucAucAAGGdTsdT	sense

1176-1195	7507	CCUUGAUGAUCUCCACAAG	7508	CCUUGAUGAUCUCcAcAAGdTsdT	antis

1177-1196	7509	UUGUGGAGAUCAUCAAGGU	7510	uuGuGGAGAucAucAAGGudTsdT	sense

1177-1196	7511	ACCUUGAUGAUCUCCACAA	7512	ACCUUGAUGAUCUCcAcAAdTsdT	antis

1179-1198	7513	GUGGAGAUCAUCAAGGUAC	7514	GuGGAGAucAucAAGGuAcdTsdT	sense

1179-1198	7515	GUACCUUGAUGAUCUCCAC	7516	GuACCUUGAUGAUCUCcACdTsdT	antis

1180-1199	7517	UGGAGAUCAUCAAGGUACU	7518	uGGAGAucAucAAGGuAcudTsdT	sense

1180-1199	7519	AGUACCUUGAUGAUCUCCA	7520	AGuACCUUGAUGAUCUCcAdTsdT	antis

1181-1200	7521	GGAGAUCAUCAAGGUACUA	7522	GGAGAucAucAAGGuAcuAdTsdT	sense

1181-1200	7523	UAGUACCUUGAUGAUCUCC	7524	uAGuACCUUGAUGAUCUCCdTsdT	antis

1182-1201	7525	GAGAUCAUCAAGGUACUAG	7526	GAGAucAucAAGGuAcuAGdTsdT	sense

1182-1201	7527	CUAGUACCUUGAUGAUCUC	7528	CuAGuACCUUGAUGAUCUCdTsdT	antis

1184-1203	7529	GAUCAUCAAGGUACUAGGA	7530	GAucAucAAGGuAcuAGGAdTsdT	sense

1184-1203	7531	UCCUAGUACCUUGAUGAUC	7532	UCCuAGuACCUUGAUGAUCdTsdT	antis

1186-1205	7533	UCAUCAAGGUACUAGGAAC	7534	ucAucAAGGuAcuAGGAAcdTsdT	sense

1186-1205	7535	GUUCCUAGUACCUUGAUGA	7536	GUUCCuAGuACCUUGAUGAdTsdT	antis

1187-1206	7537	CAUCAAGGUACUAGGAACG	7538	cAucAAGGuAcuAGGAAcGdTsdT	sense

1187-1206	7539	CGUUCCUAGUACCUUGAUG	7540	CGUUCCuAGuACCUUGAUGdTsdT	antis

1205-1224	7541	GCCAACCAGGGAACAAAUC	7542	GccAAccAGGGAAcAAAucdTsdT	sense

1205-1224	7543	GAUUUGUUCCCUGGUUGGC	7544	GAUUUGUUCCCUGGUUGGCdTsdT	antis

1207-1226	7545	CAACCAGGGAACAAAUCCG	7546	cAAccAGGGAAcAAAuccGdTsdT	sense

1207-1226	7547	CGGAUUUGUUCCCUGGUUG	7548	CGGAUUUGUUCCCUGGUUGdTsdT	antis

1209-1228	7549	ACCAGGGAACAAAUCCGAG	7550	AccAGGGAAcAAAuccGAGdTsdT	sense

1209-1228	7551	CUCGGAUUUGUUCCCUGGU	7552	CUCGGAUUUGUUCCCUGGUdTsdT	antis

1212-1231	7553	AGGGAACAAAUCCGAGAGA	7554	AGGGAAcAAAuccGAGAGAdTsdT	sense

1212-1231	7555	UCUCUCGGAUUUGUUCCCU	7556	UCUCUCGGAUUUGUUCCCUdTsdT	antis

1214-1233	7557	GGAACAAAUCCGAGAGAUG	7558	GGAAcAAAuccGAGAGAuGdTsdT	sense

1214-1233	7559	CAUCUCUCGGAUUUGUUCC	7560	cAUCUCUCGGAUUUGUUCCdTsdT	antis

1219-1238	7561	AAAUCCGAGAGAUGAACCC	7562	AAAuccGAGAGAuGAAcccdTsdT	sense

1219-1238	7563	GGGUUCAUCUCUCGGAUUU	7564	GGGUUcAUCUCUCGGAUUUdTsdT	antis

1222-1241	7565	UCCGAGAGAUGAACCCUAA	7566	uccGAGAGAuGAAcccuAAdTsdT	sense

1222-1241	7567	UUAGGGUUCAUCUCUCGGA	7568	UuAGGGUUcAUCUCUCGGAdTsdT	antis

1223-1242	7569	CCGAGAGAUGAACCCUAAC	7570	ccGAGAGAuGAAcccuAAcdTsdT	sense

1223-1242	7571	GUUAGGGUUCAUCUCUCGG	7572	GUuAGGGUUcAUCUCUCGGdTsdT	antis

1247-1266	7573	GGAGUUCAAGUUCCCCCAG	7574	GGAGuucAAGuucccccAGdTsdT	sense

1247-1266	7575	CUGGGGGAACUUGAACUCC	7576	CUGGGGGAACUUGAACUCCdTsdT	antis

1248-1267	7577	GAGUUCAAGUUCCCCCAGA	7578	GAGuucAAGuucccccAGAdTsdT	sense

1248-1267	7579	UCUGGGGGAACUUGAACUC	7580	UCUGGGGGAACUUGAACUCdTsdT	antis

1249-1268	7581	AGUUCAAGUUCCCCCAGAU	7582	AGuucAAGuucccccAGAudTsdT	sense

1249-1268	7583	AUCUGGGGGAACUUGAACU	7584	AUCUGGGGGAACUUGAACUdTsdT	antis

1250-1269	7585	GUUCAAGUUCCCCCAGAUC	7586	GuucAAGuucccccAGAucdTsdT	sense

1250-1269	7587	GAUCUGGGGGAACUUGAAC	7588	GAUCUGGGGGAACUUGAACdTsdT	antis

1251-1270	7589	UUCAAGUUCCCCCAGAUCA	7590	uucAAGuucccccAGAucAdTsdT	sense

1251-1270	7591	UGAUCUGGGGGAACUUGAA	7592	UGAUCUGGGGGAACUUGAAdTsdT	antis

1252-1271	7593	UCAAGUUCCCCCAGAUCAA	7594	ucAAGuucccccAGAucAAdTsdT	sense

1252-1271	7595	UUGAUCUGGGGGAACUUGA	7596	UUGAUCUGGGGGAACUUGAdTsdT	antis

1253-1272	7597	CAAGUUCCCCCAGAUCAAA	7598	cAAGuucccccAGAucAAAdTsdT	sense

1253-1272	7599	UUUGAUCUGGGGGAACUUG	7600	UUUGAUCUGGGGGAACUUGdTsdT	antis

1255-1274	7601	AGUUCCCCCAGAUCAAAGC	7602	AGuucccccAGAucAAAGcdTsdT	sense

1255-1274	7603	GCUUUGAUCUGGGGGAACU	7604	GCUUUGAUCUGGGGGAACUdTsdT	antis

1257-1276	7605	UUCCCCCAGAUCAAAGCUC	7606	uucccccAGAucAAAGcucdTsdT	sense

1257-1276	7607	GAGCUUUGAUCUGGGGGAA	7608	GAGCUUUGAUCUGGGGGAAdTsdT	antis

1258-1277	7609	UCCCCCAGAUCAAAGCUCA	7610	ucccccAGAucAAAGcucAdTsdT	sense

1258-1277	7611	UGAGCUUUGAUCUGGGGGA	7612	UGAGCUUUGAUCUGGGGGAdTsdT	antis

1261-1280	7613	CCCAGAUCAAAGCUCACCC	7614	cccAGAucAAAGcucAcccdTsdT	sense

1261-1280	7615	GGGUGAGCUUUGAUCUGGG	7616	GGGUGAGCUUUGAUCUGGGdTsdT	antis

1262-1281	7617	CCAGAUCAAAGCUCACCCU	7618	ccAGAucAAAGcucAcccudTsdT	sense

1262-1281	7619	AGGGUGAGCUUUGAUCUGG	7620	AGGGUGAGCUUUGAUCUGGdTsdT	antis

1280-1299	7621	UUGGACAAAGGUGUUCAAA	7622	uuGGAcAAAGGuGuucAAAdTsdT	sense

1280-1299	7623	UUUGAACACCUUUGUCCAA	7624	UUUGAAcACCUUUGUCcAAdTsdT	antis

1282-1301	7625	GGACAAAGGUGUUCAAAUC	7626	GGAcAAAGGuGuucAAAucdTsdT	sense

1282-1301	7627	GAUUUGAACACCUUUGUCC	7628	GAUUUGAAcACCUUUGUCCdTsdT	antis

1283-1302	7629	GACAAAGGUGUUCAAAUCU	7630	GAcAAAGGuGuucAAAucudTsdT	sense

1283-1302	7631	AGAUUUGAACACCUUUGUC	7632	AGAUUUGAAcACCUUUGUCdTsdT	antis

1284-1303	7633	ACAAAGGUGUUCAAAUCUU	7634	AcAAAGGuGuucAAAucuudTsdT	sense

1284-1303	7635	AAGAUUUGAACACCUUUGU	7636	AAGAUUUGAAcACCUUUGUdTsdT	antis

1354-1373	7637	CGCCAUCCUCAAGGCUCUC	7638	cGccAuccucAAGGcucucdTsdT	sense

1354-1373	7639	GAGAGCCUUGAGGAUGGCG	7640	GAGAGCCUUGAGGAUGGCGdTsdT	antis

1361-1380	7641	CUCAAGGCUCUCCCCACUC	7642	cucAAGGcucuccccAcucdTsdT	sense

1361-1380	7643	GAGUGGGGAGAGCCUUGAG	7644	GAGUGGGGAGAGCCUUGAGdTsdT	antis

1379-1398	7645	CGAGGCUUGUGCCCACAGC	7646	cGAGGcuuGuGcccAcAGcdTsdT	sense

1379-1398	7647	GCUGUGGGCACAAGCCUCG	7648	GCUGUGGGcAcAAGCCUCGdTsdT	antis

1380-1399	7649	GAGGCUUGUGCCCACAGCU	7650	GAGGcuuGuGcccAcAGcudTsdT	sense

1380-1399	7651	AGCUGUGGGCACAAGCCUC	7652	AGCUGUGGGcAcAAGCCUCdTsdT	antis

1382-1401	7653	GGCUUGUGCCCACAGCUUC	7654	GGcuuGuGcccAcAGcuucdTsdT	sense

1382-1401	7655	GAAGCUGUGGGCACAAGCC	7656	GAAGCUGUGGGcAcAAGCCdTsdT	antis

1383-1402	7657	GCUUGUGCCCACAGCUUCU	7658	GcuuGuGcccAcAGcuucudTsdT	sense

1383-1402	7659	AGAAGCUGUGGGCACAAGC	7660	AGAAGCUGUGGGcAcAAGCdTsdT	antis

1384-1403	7661	CUUGUGCCCACAGCUUCUU	7662	cuuGuGcccAcAGcuucuudTsdT	sense

1384-1403	7663	AAGAAGCUGUGGGCACAAG	7664	AAGAAGCUGUGGGcAcAAGdTsdT	antis

1386-1405	7665	UGUGCCCACAGCUUCUUCG	7666	uGuGcccAcAGcuucuucGdTsdT	sense

1386-1405	7667	CGAAGAAGCUGUGGGCACA	7668	CGAAGAAGCUGUGGGcAcAdTsdT	antis

1424-1443	7669	AGCCCAGCUCCCCAACGAC	7670	AGcccAGcuccccAAcGAcdTsdT	sense

1424-1443	7671	GUCGUUGGGGAGCUGGGCU	7672	GUCGUUGGGGAGCUGGGCUdTsdT	antis

1425-1444	7673	GCCCAGCUCCCCAACGACC	7674	GcccAGcuccccAAcGAccdTsdT	sense

1425-1444	7675	GGUCGUUGGGGAGCUGGGC	7676	GGUCGUUGGGGAGCUGGGCdTsdT	antis

1426-1445	7677	CCCAGCUCCCCAACGACCG	7678	cccAGcuccccAAcGAccGdTsdT	sense

1426-1445	7679	CGGUCGUUGGGGAGCUGGG	7680	CGGUCGUUGGGGAGCUGGGdTsdT	antis

1427-1446	7681	CCAGCUCCCCAACGACCGC	7682	ccAGcuccccAAcGAccGcdTsdT	sense

1427-1446	7683	GCGGUCGUUGGGGAGCUGG	7684	GCGGUCGUUGGGGAGCUGGdTsdT	antis

1428-1447	7685	CAGCUCCCCAACGACCGCC	7686	cAGcuccccAAcGAccGccdTsdT	sense

1428-1447	7687	GGCGGUCGUUGGGGAGCUG	7688	GGCGGUCGUUGGGGAGCUGdTsdT	antis

1454-1473	7689	CCCCCUGUUCAACUUCAGU	7690	cccccuGuucAAcuucAGudTsdT	sense

1454-1473	7691	ACUGAAGUUGAACAGGGGG	7692	ACUGAAGUUGAAcAGGGGGdTsdT	antis

1459-1478	7693	UGUUCAACUUCAGUCCUGG	7694	uGuucAAcuucAGuccuGGdTsdT	sense

1459-1478	7695	CCAGGACUGAAGUUGAACA	7696	CcAGGACUGAAGUUGAAcAdTsdT	antis

1460-1479	7697	GUUCAACUUCAGUCCUGGU	7698	GuucAAcuucAGuccuGGudTsdT	sense

1460-1479	7699	ACCAGGACUGAAGUUGAAC	7700	ACcAGGACUGAAGUUGAACdTsdT	antis

1461-1480	7701	UUCAACUUCAGUCCUGGUG	7702	uucAAcuucAGuccuGGuGdTsdT	sense

1461-1480	7703	CACCAGGACUGAAGUUGAA	7704	cACcAGGACUGAAGUUGAAdTsdT	antis

1462-1481	7705	UCAACUUCAGUCCUGGUGA	7706	ucAAcuucAGuccuGGuGAdTsdT	sense

1462-1481	7707	UCACCAGGACUGAAGUUGA	7708	UcACcAGGACUGAAGUUGAdTsdT	antis

1463-1482	7709	CAACUUCAGUCCUGGUGAA	7710	cAAcuucAGuccuGGuGAAdTsdT	sense

1463-1482	7711	UUCACCAGGACUGAAGUUG	7712	UUcACcAGGACUGAAGUUGdTsdT	antis

1503-1522	7713	AAUGCCAUUCUCAUCCCUC	7714	AAuGccAuucucAucccucdTsdT	sense

1503-1522	7715	GAGGGAUGAGAAUGGCAUU	7716	GAGGGAUGAGAAUGGcAUUdTsdT	antis

1504-1523	7717	AUGCCAUUCUCAUCCCUCC	7718	AuGccAuucucAucccuccdTsdT	sense

1504-1523	7719	GGAGGGAUGAGAAUGGCAU	7720	GGAGGGAUGAGAAUGGcAUdTsdT	antis

1505-1524	7721	UGCCAUUCUCAUCCCUCCU	7722	uGccAuucucAucccuccudTsdT	sense

1505-1524	7723	AGGAGGGAUGAGAAUGGCA	7724	AGGAGGGAUGAGAAUGGcAdTsdT	antis

1506-1525	7725	GCCAUUCUCAUCCCUCCUC	7726	GccAuucucAucccuccucdTsdT	sense

1506-1525	7727	GAGGAGGGAUGAGAAUGGC	7728	GAGGAGGGAUGAGAAUGGCdTsdT	antis

1507-1526	7729	CCAUUCUCAUCCCUCCUCA	7730	ccAuucucAucccuccucAdTsdT	sense

1507-1526	7731	UGAGGAGGGAUGAGAAUGG	7732	UGAGGAGGGAUGAGAAUGGdTsdT	antis

1508-1527	7733	CAUUCUCAUCCCUCCUCAC	7734	cAuucucAucccuccucAcdTsdT	sense

1508-1527	7735	GUGAGGAGGGAUGAGAAUG	7736	GUGAGGAGGGAUGAGAAUGdTsdT	antis

1509-1528	7737	AUUCUCAUCCCUCCUCACU	7738	AuucucAucccuccucAcudTsdT	sense

1509-1528	7739	AGUGAGGAGGGAUGAGAAU	7740	AGUGAGGAGGGAUGAGAAUdTsdT	antis

1510-1529	7741	UUCUCAUCCCUCCUCACUU	7742	uucucAucccuccucAcuudTsdT	sense

1510-1529	7743	AAGUGAGGAGGGAUGAGAA	7744	AAGUGAGGAGGGAUGAGAAdTsdT	antis

1511-1530	7745	UCUCAUCCCUCCUCACUUG	7746	ucucAucccuccucAcuuGdTsdT	sense

1511-1530	7747	CAAGUGAGGAGGGAUGAGA	7748	cAAGUGAGGAGGGAUGAGAdTsdT	antis

1515-1534	7749	AUCCCUCCUCACUUGAGGU	7750	AucccuccucAcuuGAGGudTsdT	sense

1515-1534	7751	ACCUCAAGUGAGGAGGGAU	7752	ACCUcAAGUGAGGAGGGAUdTsdT	antis

1516-1535	7753	UCCCUCCUCACUUGAGGUC	7754	ucccuccucAcuuGAGGucdTsdT	sense

1516-1535	7755	GACCUCAAGUGAGGAGGGA	7756	GACCUcAAGUGAGGAGGGAdTsdT	antis

1520-1539	7757	UCCUCACUUGAGGUCCCCA	7758	uccucAcuuGAGGuccccAdTsdT	sense

1520-1539	7759	UGGGGACCUCAAGUGAGGA	7760	UGGGGACCUcAAGUGAGGAdTsdT	antis

1522-1541	7761	CUCACUUGAGGUCCCCAGC	7762	cucAcuuGAGGuccccAGcdTsdT	sense

1522-1541	7763	GCUGGGGACCUCAAGUGAG	7764	GCUGGGGACCUcAAGUGAGdTsdT	antis

1523-1542	7765	UCACUUGAGGUCCCCAGCA	7766	ucAcuuGAGGuccccAGcAdTsdT	sense

1523-1542	7767	UGCUGGGGACCUCAAGUGA	7768	UGCUGGGGACCUcAAGUGAdTsdT	antis

1524-1543	7769	CACUUGAGGUCCCCAGCAG	7770	cAcuuGAGGuccccAGcAGdTsdT	sense

1524-1543	7771	CUGCUGGGGACCUCAAGUG	7772	CUGCUGGGGACCUcAAGUGdTsdT	antis

1528-1547	7773	UGAGGUCCCCAGCAGGCCC	7774	uGAGGuccccAGcAGGcccdTsdT	sense

1528-1547	7775	GGGCCUGCUGGGGACCUCA	7776	GGGCCUGCUGGGGACCUcAdTsdT	antis

1529-1548	7777	GAGGUCCCCAGCAGGCCCU	7778	GAGGuccccAGcAGGcccudTsdT	sense

1529-1548	7779	AGGGCCUGCUGGGGACCUC	7780	AGGGCCUGCUGGGGACCUCdTsdT	antis

1539-1558	7781	GCAGGCCCUGCUUCUCCCC	7782	GcAGGcccuGcuucuccccdTsdT	sense

1539-1558	7783	GGGGAGAAGCAGGGCCUGC	7784	GGGGAGAAGcAGGGCCUGCdTsdT	antis

1577-1596	7785	AUCCUCACAAGCUUUAACU	7786	AuccucAcAAGcuuuAAcudTsdT	sense

1577-1596	7787	AGUUAAAGCUUGUGAGGAU	7788	AGUuAAAGCUUGUGAGGAUdTsdT	antis

1578-1597	7789	UCCUCACAAGCUUUAACUG	7790	uccucAcAAGcuuuAAcuGdTsdT	sense

1578-1597	7791	CAGUUAAAGCUUGUGAGGA	7792	cAGUuAAAGCUUGUGAGGAdTsdT	antis

1579-1598	7793	CCUCACAAGCUUUAACUGA	7794	ccucAcAAGcuuuAAcuGAdTsdT	sense

1579-1598	7795	UCAGUUAAAGCUUGUGAGG	7796	UcAGUuAAAGCUUGUGAGGdTsdT	antis

1582-1601	7797	CACAAGCUUUAACUGAAGC	7798	cAcAAGcuuuAAcuGAAGcdTsdT	sense

1582-1601	7799	GCUUCAGUUAAAGCUUGUG	7800	GCUUcAGUuAAAGCUUGUGdTsdT	antis

1587-1606	7801	GCUUUAACUGAAGCUCAGA	7802	GcuuuAAcuGAAGcucAGAdTsdT	sense

1587-1606	7803	UCUGAGCUUCAGUUAAAGC	7804	UCUGAGCUUcAGUuAAAGCdTsdT	antis

1623-1642	7805	CCAUCUGAUGCCACAACUG	7806	ccAucuGAuGccAcAAcuGdTsdT	sense

1623-1642	7807	CAGUUGUGGCAUCAGAUGG	7808	cAGUUGUGGcAUcAGAUGGdTsdT	antis

1624-1643	7809	CAUCUGAUGCCACAACUGC	7810	cAucuGAuGccAcAAcuGcdTsdT	sense

1624-1643	7811	GCAGUUGUGGCAUCAGAUG	7812	GcAGUUGUGGcAUcAGAUGdTsdT	antis

1625-1644	7813	AUCUGAUGCCACAACUGCU	7814	AucuGAuGccAcAAcuGcudTsdT	sense

1625-1644	7815	AGCAGUUGUGGCAUCAGAU	7816	AGcAGUUGUGGcAUcAGAUdTsdT	antis

1630-1649	7817	AUGCCACAACUGCUACCCU	7818	AuGccAcAAcuGcuAcccudTsdT	sense

1630-1649	7819	AGGGUAGCAGUUGUGGCAU	7820	AGGGuAGcAGUUGUGGcAUdTsdT	antis

1631-1650	7821	UGCCACAACUGCUACCCUC	7822	uGccAcAAcuGcuAcccucdTsdT	sense

1631-1650	7823	GAGGGUAGCAGUUGUGGCA	7824	GAGGGuAGcAGUUGUGGcAdTsdT	antis

1632-1651	7825	GCCACAACUGCUACCCUCG	7826	GccAcAAcuGcuAcccucGdTsdT	sense

1632-1651	7827	CGAGGGUAGCAGUUGUGGC	7828	CGAGGGuAGcAGUUGUGGCdTsdT	antis

1633-1652	7829	CCACAACUGCUACCCUCGC	7830	ccAcAAcuGcuAcccucGcdTsdT	sense

1633-1652	7831	GCGAGGGUAGCAGUUGUGG	7832	GCGAGGGuAGcAGUUGUGGdTsdT	antis

1668-1687	7833	CCCCACCGACUACCCCUCC	7834	ccccAccGAcuAccccuccdTsdT	sense

1668-1687	7835	GGAGGGGUAGUCGGUGGGG	7836	GGAGGGGuAGUCGGUGGGGdTsdT	antis

1678-1697	7837	UACCCCUCCACGUCCAUCU	7838	uAccccuccAcGuccAucudTsdT	sense

1678-1697	7839	AGAUGGACGUGGAGGGGUA	7840	AGAUGGACGUGGAGGGGuAdTsdT	antis

1681-1700	7841	CCCUCCACGUCCAUCUGGG	7842	cccuccAcGuccAucuGGGdTsdT	sense

1681-1700	7843	CCCAGAUGGACGUGGAGGG	7844	CCcAGAUGGACGUGGAGGGdTsdT	antis

1683-1702	7845	CUCCACGUCCAUCUGGGAA	7846	cuccAcGuccAucuGGGAAdTsdT	sense

1683-1702	7847	UUCCCAGAUGGACGUGGAG	7848	UUCCcAGAUGGACGUGGAGdTsdT	antis

1690-1709	7849	UCCAUCUGGGAAGGCCCAA	7850	uccAucuGGGAAGGcccAAdTsdT	sense

1690-1709	7851	UUGGGCCUUCCCAGAUGGA	7852	UUGGGCCUUCCcAGAUGGAdTsdT	antis

1691-1710	7853	CCAUCUGGGAAGGCCCAAG	7854	ccAucuGGGAAGGcccAAGdTsdT	sense

1691-1710	7855	CUUGGGCCUUCCCAGAUGG	7856	CUUGGGCCUUCCcAGAUGGdTsdT	antis

1692-1711	7857	CAUCUGGGAAGGCCCAAGU	7858	cAucuGGGAAGGcccAAGudTsdT	sense

1692-1711	7859	ACUUGGGCCUUCCCAGAUG	7860	ACUUGGGCCUUCCcAGAUGdTsdT	antis

1693-1712	7861	AUCUGGGAAGGCCCAAGUG	7862	AucuGGGAAGGcccAAGuGdTsdT	sense

1693-1712	7863	CACUUGGGCCUUCCCAGAU	7864	cACUUGGGCCUUCCcAGAUdTsdT	antis

1696-1715	7865	UGGGAAGGCCCAAGUGGCG	7866	uGGGAAGGcccAAGuGGcGdTsdT	sense

1696-1715	7867	CGCCACUUGGGCCUUCCCA	7868	CGCcACUUGGGCCUUCCcAdTsdT	antis

1697-1716	7869	GGGAAGGCCCAAGUGGCGC	7870	GGGAAGGcccAAGuGGcGcdTsdT	sense

1697-1716	7871	GCGCCACUUGGGCCUUCCC	7872	GCGCcACUUGGGCCUUCCCdTsdT	antis

1698-1717	7873	GGAAGGCCCAAGUGGCGCU	7874	GGAAGGcccAAGuGGcGcudTsdT	sense

1698-1717	7875	AGCGCCACUUGGGCCUUCC	7876	AGCGCcACUUGGGCCUUCCdTsdT	antis

1699-1718	7877	GAAGGCCCAAGUGGCGCUG	7878	GAAGGcccAAGuGGcGcuGdTsdT	sense

1699-1718	7879	CAGCGCCACUUGGGCCUUC	7880	cAGCGCcACUUGGGCCUUCdTsdT	antis

1700-1719	7881	AAGGCCCAAGUGGCGCUGG	7882	AAGGcccAAGuGGcGcuGGdTsdT	sense

1700-1719	7883	CCAGCGCCACUUGGGCCUU	7884	CcAGCGCcACUUGGGCCUUdTsdT	antis

1701-1720	7885	AGGCCCAAGUGGCGCUGGG	7886	AGGcccAAGuGGcGcuGGGdTsdT	sense

1701-1720	7887	CCCAGCGCCACUUGGGCCU	7888	CCcAGCGCcACUUGGGCCUdTsdT	antis

1702-1721	7889	GGCCCAAGUGGCGCUGGGA	7890	GGcccAAGuGGcGcuGGGAdTsdT	sense

1702-1721	7891	UCCCAGCGCCACUUGGGCC	7892	UCCcAGCGCcACUUGGGCCdTsdT	antis

1707-1726	7893	AAGUGGCGCUGGGAAGGGG	7894	AAGuGGcGcuGGGAAGGGGdTsdT	sense

1707-1726	7895	CCCCUUCCCAGCGCCACUU	7896	CCCCUUCCcAGCGCcACUUdTsdT	antis

1708-1727	7897	AGUGGCGCUGGGAAGGGGG	7898	AGuGGcGcuGGGAAGGGGGdTsdT	sense

1708-1727	7899	CCCCCUUCCCAGCGCCACU	7900	CCCCCUUCCcAGCGCcACUdTsdT	antis

1712-1731	7901	GCGCUGGGAAGGGGGCCAC	7902	GcGcuGGGAAGGGGGccAcdTsdT	sense

1712-1731	7903	GUGGCCCCCUUCCCAGCGC	7904	GUGGCCCCCUUCCcAGCGCdTsdT	antis

1713-1732	7905	CGCUGGGAAGGGGGCCACA	7906	cGcuGGGAAGGGGGccAcAdTsdT	sense

1713-1732	7907	UGUGGCCCCCUUCCCAGCG	7908	UGUGGCCCCCUUCCcAGCGdTsdT	antis

1715-1734	7909	CUGGGAAGGGGGCCACAGC	7910	cuGGGAAGGGGGccAcAGcdTsdT	sense

1715-1734	7911	GCUGUGGCCCCCUUCCCAG	7912	GCUGUGGCCCCCUUCCcAGdTsdT	antis

1716-1735	7913	UGGGAAGGGGGCCACAGCC	7914	uGGGAAGGGGGccAcAGccdTsdT	sense

1716-1735	7915	GGCUGUGGCCCCCUUCCCA	7916	GGCUGUGGCCCCCUUCCcAdTsdT	antis

1717-1736	7917	GGGAAGGGGGCCACAGCCC	7918	GGGAAGGGGGccAcAGcccdTsdT	sense

1717-1736	7919	GGGCUGUGGCCCCCUUCCC	7920	GGGCUGUGGCCCCCUUCCCdTsdT	antis

1718-1737	7921	GGAAGGGGGCCACAGCCCA	7922	GGAAGGGGGccAcAGcccAdTsdT	sense

1718-1737	7923	UGGGCUGUGGCCCCCUUCC	7924	UGGGCUGUGGCCCCCUUCCdTsdT	antis

1719-1738	7925	GAAGGGGGCCACAGCCCAU	7926	GAAGGGGGccAcAGcccAudTsdT	sense

1719-1738	7927	AUGGGCUGUGGCCCCCUUC	7928	AUGGGCUGUGGCCCCCUUCdTsdT	antis

1720-1739	7929	AAGGGGGCCACAGCCCAUC	7930	AAGGGGGccAcAGcccAucdTsdT	sense

1720-1739	7931	GAUGGGCUGUGGCCCCCUU	7932	GAUGGGCUGUGGCCCCCUUdTsdT	antis

1721-1740	7933	AGGGGGCCACAGCCCAUCA	7934	AGGGGGccAcAGcccAucAdTsdT	sense

1721-1740	7935	UGAUGGGCUGUGGCCCCCU	7936	UGAUGGGCUGUGGCCCCCUdTsdT	antis

1724-1743	7937	GGGCCACAGCCCAUCAAGC	7938	GGGccAcAGcccAucAAGcdTsdT	sense

1724-1743	7939	GCUUGAUGGGCUGUGGCCC	7940	GCUUGAUGGGCUGUGGCCCdTsdT	antis

1725-1744	7941	GGCCACAGCCCAUCAAGCU	7942	GGccAcAGcccAucAAGcudTsdT	sense

1725-1744	7943	AGCUUGAUGGGCUGUGGCC	7944	AGCUUGAUGGGCUGUGGCCdTsdT	antis

1727-1746	7945	CCACAGCCCAUCAAGCUCC	7946	ccAcAGcccAucAAGcuccdTsdT	sense

1727-1746	7947	GGAGCUUGAUGGGCUGUGG	7948	GGAGCUUGAUGGGCUGUGGdTsdT	antis

1728-1747	7949	CACAGCCCAUCAAGCUCCU	7950	cAcAGcccAucAAGcuccudTsdT	sense

1728-1747	7951	AGGAGCUUGAUGGGCUGUG	7952	AGGAGCUUGAUGGGCUGUGdTsdT	antis

1729-1748	7953	ACAGCCCAUCAAGCUCCUG	7954	AcAGcccAucAAGcuccuGdTsdT	sense

1729-1748	7955	CAGGAGCUUGAUGGGCUGU	7956	cAGGAGCUUGAUGGGCUGUdTsdT	antis

1733-1752	7957	CCCAUCAAGCUCCUGCCCU	7958	cccAucAAGcuccuGcccudTsdT	sense

1733-1752	7959	AGGGCAGGAGCUUGAUGGG	7960	AGGGcAGGAGCUUGAUGGGdTsdT	antis

1734-1753	7961	CCAUCAAGCUCCUGCCCUG	7962	ccAucAAGcuccuGcccuGdTsdT	sense

1734-1753	7963	CAGGGCAGGAGCUUGAUGG	7964	cAGGGcAGGAGCUUGAUGGdTsdT	antis

1735-1754	7965	CAUCAAGCUCCUGCCCUGG	7966	cAucAAGcuccuGcccuGGdTsdT	sense

1735-1754	7967	CCAGGGCAGGAGCUUGAUG	7968	CcAGGGcAGGAGCUUGAUGdTsdT	antis

1736-1755	7969	AUCAAGCUCCUGCCCUGGC	7970	AucAAGcuccuGcccuGGcdTsdT	sense

1736-1755	7971	GCCAGGGCAGGAGCUUGAU	7972	GCcAGGGcAGGAGCUUGAUdTsdT	antis

1738-1757	7973	CAAGCUCCUGCCCUGGCUG	7974	cAAGcuccuGcccuGGcuGdTsdT	sense

1738-1757	7975	CAGCCAGGGCAGGAGCUUG	7976	cAGCcAGGGcAGGAGCUUGdTsdT	antis

1739-1758	7977	AAGCUCCUGCCCUGGCUGG	7978	AAGcuccuGcccuGGcuGGdTsdT	sense

1739-1758	7979	CCAGCCAGGGCAGGAGCUU	7980	CcAGCcAGGGcAGGAGCUUdTsdT	antis

1742-1761	7981	CUCCUGCCCUGGCUGGGCC	7982	cuccuGcccuGGcuGGGccdTsdT	sense

1742-1761	7983	GGCCCAGCCAGGGCAGGAG	7984	GGCCcAGCcAGGGcAGGAGdTsdT	antis

1745-1764	7985	CUGCCCUGGCUGGGCCCCU	7986	cuGcccuGGcuGGGccccudTsdT	sense

1745-1764	7987	AGGGGCCCAGCCAGGGCAG	7988	AGGGGCCcAGCcAGGGcAGdTsdT	antis

1747-1766	7989	GCCCUGGCUGGGCCCCUAG	7990	GcccuGGcuGGGccccuAGdTsdT	sense

1747-1766	7991	CUAGGGGCCCAGCCAGGGC	7992	CuAGGGGCCcAGCcAGGGCdTsdT	antis

1749-1768	7993	CCUGGCUGGGCCCCUAGAC	7994	ccuGGcuGGGccccuAGAcdTsdT	sense

1749-1768	7995	GUCUAGGGGCCCAGCCAGG	7996	GUCuAGGGGCCcAGCcAGGdTsdT	antis

1750-1769	7997	CUGGCUGGGCCCCUAGACU	7998	cuGGcuGGGccccuAGAcudTsdT	sense

1750-1769	7999	AGUCUAGGGGCCCAGCCAG	8000	AGUCuAGGGGCCcAGCcAGdTsdT	antis

1751-1770	8001	UGGCUGGGCCCCUAGACUA	8002	uGGcuGGGccccuAGAcuAdTsdT	sense

1751-1770	8003	UAGUCUAGGGGCCCAGCCA	8004	uAGUCuAGGGGCCcAGCcAdTsdT	antis

1754-1773	8005	CUGGGCCCCUAGACUAGAG	8006	cuGGGccccuAGAcuAGAGdTsdT	sense

1754-1773	8007	CUCUAGUCUAGGGGCCCAG	8008	CUCuAGUCuAGGGGCCcAGdTsdT	antis

1756-1775	8009	GGGCCCCUAGACUAGAGGG	8010	GGGccccuAGAcuAGAGGGdTsdT	sense

1756-1775	8011	CCCUCUAGUCUAGGGGCCC	8012	CCCUCuAGUCuAGGGGCCCdTsdT	antis

1757-1776	8013	GGCCCCUAGACUAGAGGGC	8014	GGccccuAGAcuAGAGGGcdTsdT	sense

1757-1776	8015	GCCCUCUAGUCUAGGGGCC	8016	GCCCUCuAGUCuAGGGGCCdTsdT	antis

1762-1781	8017	CUAGACUAGAGGGCAGAGG	8018	cuAGAcuAGAGGGcAGAGGdTsdT	sense

1762-1781	8019	CCUCUGCCCUCUAGUCUAG	8020	CCUCUGCCCUCuAGUCuAGdTsdT	antis

1766-1785	8021	ACUAGAGGGCAGAGGUAAA	8022	AcuAGAGGGcAGAGGuAAAdTsdT	sense

1766-1785	8023	UUUACCUCUGCCCUCUAGU	8024	UUuACCUCUGCCCUCuAGUdTsdT	antis

1768-1787	8025	UAGAGGGCAGAGGUAAAUG	8026	uAGAGGGcAGAGGuAAAuGdTsdT	sense

1768-1787	8027	CAUUUACCUCUGCCCUCUA	8028	cAUUuACCUCUGCCCUCuAdTsdT	antis

1771-1790	8029	AGGGCAGAGGUAAAUGAAC	8030	AGGGcAGAGGuAAAuGAAcdTsdT	sense

1771-1790	8031	GUUCAUUUACCUCUGCCCU	8032	GUUcAUUuACCUCUGCCCUdTsdT	antis

1776-1795	8033	AGAGGUAAAUGAACUACCC	8034	AGAGGuAAAuGAAcuAcccdTsdT	sense

1776-1795	8035	GGGUAGUUCAUUUACCUCU	8036	GGGuAGUUcAUUuACCUCUdTsdT	antis

1783-1802	8037	AAUGAACUACCCCCAGCAU	8038	AAuGAAcuAcccccAGcAudTsdT	sense

1783-1802	8039	AUGCUGGGGGUAGUUCAUU	8040	AUGCUGGGGGuAGUUcAUUdTsdT	antis

1788-1807	8041	ACUACCCCCAGCAUCUAGG	8042	AcuAcccccAGcAucuAGGdTsdT	sense

1788-1807	8043	CCUAGAUGCUGGGGGUAGU	8044	CCuAGAUGCUGGGGGuAGUdTsdT	antis

1789-1808	8045	CUACCCCCAGCAUCUAGGC	8046	cuAcccccAGcAucuAGGcdTsdT	sense

1789-1808	8047	GCCUAGAUGCUGGGGGUAG	8048	GCCuAGAUGCUGGGGGuAGdTsdT	antis

1791-1810	8049	ACCCCCAGCAUCUAGGCCU	8050	AcccccAGcAucuAGGccudTsdT	sense

1791-1810	8051	AGGCCUAGAUGCUGGGGGU	8052	AGGCCuAGAUGCUGGGGGUdTsdT	antis

1793-1812	8053	CCCCAGCAUCUAGGCCUCC	8054	ccccAGcAucuAGGccuccdTsdT	sense

1793-1812	8055	GGAGGCCUAGAUGCUGGGG	8056	GGAGGCCuAGAUGCUGGGGdTsdT	antis

1797-1816	8057	AGCAUCUAGGCCUCCCUCA	8058	AGcAucuAGGccucccucAdTsdT	sense

1797-1816	8059	UGAGGGAGGCCUAGAUGCU	8060	UGAGGGAGGCCuAGAUGCUdTsdT	antis

1822-1841	8061	UAACCUCUGUGGUGGGCUU	8062	uAAccucuGuGGuGGGcuudTsdT	sense

1822-1841	8063	AAGCCCACCACAGAGGUUA	8064	AAGCCcACcAcAGAGGUuAdTsdT	antis

1823-1842	8065	AACCUCUGUGGUGGGCUUU	8066	AAccucuGuGGuGGGcuuudTsdT	sense

1823-1842	8067	AAAGCCCACCACAGAGGUU	8068	AAAGCCcACcAcAGAGGUUdTsdT	antis

1826-1845	8069	CUCUGUGGUGGGCUUUUUA	8070	cucuGuGGuGGGcuuuuuAdTsdT	sense

1826-1845	8071	UAAAAAGCCCACCACAGAG	8072	uAAAAAGCCcACcAcAGAGdTsdT	antis

1827-1846	8073	UCUGUGGUGGGCUUUUUAA	8074	ucuGuGGuGGGcuuuuuAAdTsdT	sense

1827-1846	8075	UUAAAAAGCCCACCACAGA	8076	UuAAAAAGCCcACcAcAGAdTsdT	antis

1828-1847	8077	CUGUGGUGGGCUUUUUAAA	8078	cuGuGGuGGGcuuuuuAAAdTsdT	sense

1828-1847	8079	UUUAAAAAGCCCACCACAG	8080	UUuAAAAAGCCcACcAcAGdTsdT	antis

1829-1848	8081	UGUGGUGGGCUUUUUAAAG	8082	uGuGGuGGGcuuuuuAAAGdTsdT	sense

1829-1848	8083	CUUUAAAAAGCCCACCACA	8084	CUUuAAAAAGCCcACcAcAdTsdT	antis

1830-1849	8085	GUGGUGGGCUUUUUAAAGA	8086	GuGGuGGGcuuuuuAAAGAdTsdT	sense

1830-1849	8087	UCUUUAAAAAGCCCACCAC	8088	UCUUuAAAAAGCCcACcACdTsdT	antis

1832-1851	8089	GGUGGGCUUUUUAAAGAGG	8090	GGuGGGcuuuuuAAAGAGGdTsdT	sense

1832-1851	8091	CCUCUUUAAAAAGCCCACC	8092	CCUCUUuAAAAAGCCcACCdTsdT	antis

1835-1854	8093	GGGCUUUUUAAAGAGGAUU	8094	GGGcuuuuuAAAGAGGAuudTsdT	sense

1835-1854	8095	AAUCCUCUUUAAAAAGCCC	8096	AAUCCUCUUuAAAAAGCCCdTsdT	antis

1836-1855	8097	GGCUUUUUAAAGAGGAUUU	8098	GGcuuuuuAAAGAGGAuuudTsdT	sense

1836-1855	8099	AAAUCCUCUUUAAAAAGCC	8100	AAAUCCUCUUuAAAAAGCCdTsdT	antis

1884-1903	8101	AAGGACGGGGUUUGGGGGU	8102	AAGGAcGGGGuuuGGGGGudTsdT	sense

1884-1903	8103	ACCCCCAAACCCCGUCCUU	8104	ACCCCcAAACCCCGUCCUUdTsdT	antis

1886-1905	8105	GGACGGGGUUUGGGGGUGU	8106	GGAcGGGGuuuGGGGGuGudTsdT	sense

1886-1905	8107	ACACCCCCAAACCCCGUCC	8108	AcACCCCcAAACCCCGUCCdTsdT	antis

1889-1908	8109	CGGGGUUUGGGGGUGUGAG	8110	cGGGGuuuGGGGGuGuGAGdTsdT	sense

1889-1908	8111	CUCACACCCCCAAACCCCG	8112	CUcAcACCCCcAAACCCCGdTsdT	antis

1890-1909	8113	GGGGUUUGGGGGUGUGAGG	8114	GGGGuuuGGGGGuGuGAGGdTsdT	sense

1890-1909	8115	CCUCACACCCCCAAACCCC	8116	CCUcAcACCCCcAAACCCCdTsdT	antis

1891-1910	8117	GGGUUUGGGGGUGUGAGGA	8118	GGGuuuGGGGGuGuGAGGAdTsdT	sense

1891-1910	8119	UCCUCACACCCCCAAACCC	8120	UCCUcAcACCCCcAAACCCdTsdT	antis

1892-1911	8121	GGUUUGGGGGUGUGAGGAC	8122	GGuuuGGGGGuGuGAGGAcdTsdT	sense

1892-1911	8123	GUCCUCACACCCCCAAACC	8124	GUCCUcAcACCCCcAAACCdTsdT	antis

1893-1912	8125	GUUUGGGGGUGUGAGGACC	8126	GuuuGGGGGuGuGAGGAccdTsdT	sense

1893-1912	8127	GGUCCUCACACCCCCAAAC	8128	GGUCCUcAcACCCCcAAACdTsdT	antis

1894-1913	8129	UUUGGGGGUGUGAGGACCU	8130	uuuGGGGGuGuGAGGAccudTsdT	sense

1894-1913	8131	AGGUCCUCACACCCCCAAA	8132	AGGUCCUcAcACCCCcAAAdTsdT	antis

1895-1914	8133	UUGGGGGUGUGAGGACCUU	8134	uuGGGGGuGuGAGGAccuudTsdT	sense

1895-1914	8135	AAGGUCCUCACACCCCCAA	8136	AAGGUCCUcAcACCCCcAAdTsdT	antis

1914-1933	8137	CUACCCCCUUGGUCCCCUC	8138	cuAcccccuuGGuccccucdTsdT	sense

1914-1933	8139	GAGGGGACCAAGGGGGUAG	8140	GAGGGGACcAAGGGGGuAGdTsdT	antis

1915-1934	8141	UACCCCCUUGGUCCCCUCC	8142	uAcccccuuGGuccccuccdTsdT	sense

1915-1934	8143	GGAGGGGACCAAGGGGGUA	8144	GGAGGGGACcAAGGGGGuAdTsdT	antis

1916-1935	8145	ACCCCCUUGGUCCCCUCCC	8146	AcccccuuGGuccccucccdTsdT	sense

1916-1935	8147	GGGAGGGGACCAAGGGGGU	8148	GGGAGGGGACcAAGGGGGUdTsdT	antis

1917-1936	8149	CCCCCUUGGUCCCCUCCCC	8150	cccccuuGGuccccuccccdTsdT	sense

1917-1936	8151	GGGGAGGGGACCAAGGGGG	8152	GGGGAGGGGACcAAGGGGGdTsdT	antis

1918-1937	8153	CCCCUUGGUCCCCUCCCCU	8154	ccccuuGGuccccuccccudTsdT	sense

1918-1937	8155	AGGGGAGGGGACCAAGGGG	8156	AGGGGAGGGGACcAAGGGGdTsdT	antis

1919-1938	8157	CCCUUGGUCCCCUCCCCUC	8158	cccuuGGuccccuccccucdTsdT	sense

1919-1938	8159	GAGGGGAGGGGACCAAGGG	8160	GAGGGGAGGGGACcAAGGGdTsdT	antis

1920-1939	8161	CCUUGGUCCCCUCCCCUCC	8162	ccuuGGuccccuccccuccdTsdT	sense

1920-1939	8163	GGAGGGGAGGGGACCAAGG	8164	GGAGGGGAGGGGACcAAGGdTsdT	antis

1921-1940	8165	CUUGGUCCCCUCCCCUCCC	8166	cuuGGuccccuccccucccdTsdT	sense

1921-1940	8167	GGGAGGGGAGGGGACCAAG	8168	GGGAGGGGAGGGGACcAAGdTsdT	antis

1922-1941	8169	UUGGUCCCCUCCCCUCCCC	8170	uuGGuccccuccccuccccdTsdT	sense

1922-1941	8171	GGGGAGGGGAGGGGACCAA	8172	GGGGAGGGGAGGGGACcAAdTsdT	antis

2116-2135	8173	UUCUUGUCCUCUGCUCCCA	8174	uucuuGuccucuGcucccAdTsdT	sense

2116-2135	8175	UGGGAGCAGAGGACAAGAA	8176	UGGGAGcAGAGGAcAAGAAdTsdT	antis

213-232	8177	GGAGGCGGCCCUGGGGGCU	8178	GGAGGcGGcccuGGGGGcudTsdT	sense

213-232	8179	AGCCCCCAGGGCCGCCUCC	8180	AGCCCCcAGGGCCGCCUCCdTsdT	antis

358-377	8181	UGGGUGGGGGCGUGGGAGC	8182	uGGGuGGGGGcGuGGGAGcdTsdT	sense

358-377	8183	GCUCCCACGCCCCCACCCA	8184	GCUCCcACGCCCCcACCcAdTsdT	antis

528-547	8185	CGUUCCCAAGAAGUGGCUU	8186	cGuucccAAGAAGuGGcuudTsdT	sense

528-547	8187	AAGCCACUUCUUGGGAACG	8188	AAGCcACUUCUUGGGAACGdTsdT	antis

559-578	8189	AAGUGAUUGGUAAUGGCUC	8190	AAGuGAuuGGuAAuGGcucdTsdT	sense

559-578	8191	GAGCCAUUACCAAUCACUU	8192	GAGCcAUuACcAAUcACUUdTsdT	antis

623-642	8193	GGUGGCCAUCAAGAAGGUU	8194	GGuGGccAucAAGAAGGuudTsdT	sense

623-642	8195	AACCUUCUUGAUGGCCACC	8196	AACCUUCUUGAUGGCcACCdTsdT	antis

630-649	8197	AUCAAGAAGGUUCUUCAGG	8198	AucAAGAAGGuucuucAGGdTsdT	sense

630-649	8199	CCUGAAGAACCUUCUUGAU	8200	CCUGAAGAACCUUCUUGAUdTsdT	antis

633-652	8201	AAGAAGGUUCUUCAGGACA	8202	AAGAAGGuucuucAGGAcAdTsdT	sense

633-652	8203	UGUCCUGAAGAACCUUCUU	8204	UGUCCUGAAGAACCUUCUUdTsdT	antis

801-820	8205	CGAGUGGCCCGCCACUUCA	8206	cGAGuGGcccGccAcuucAdTsdT	sense

801-820	8207	UGAAGUGGCGGGCCACUCG	8208	UGAAGUGGCGGGCcACUCGdTsdT	antis

859-878	8209	UGUACAUGUACCAGCUCUU	8210	uGuAcAuGuAccAGcucuudTsdT	sense

859-878	8211	AAGAGCUGGUACAUGUACA	8212	AAGAGCUGGuAcAUGuAcAdTsdT	antis

936-955	8213	AAUUUGCUUGUGGACCCUG	8214	AAuuuGcuuGuGGAcccuGdTsdT	sense

936-955	8215	CAGGGUCCACAAGCAAAUU	8216	cAGGGUCcAcAAGcAAAUUdTsdT	antis

944-963	8217	UGUGGACCCUGACACUGCU	8218	uGuGGAcccuGAcAcuGcudTsdT	sense

944-963	8219	AGCAGUGUCAGGGUCCACA	8220	AGcAGUGUcAGGGUCcAcAdTsdT	antis

960-979	8221	GCUGUCCUCAAGCUCUGCG	8222	GcuGuccucAAGcucuGcGdTsdT	sense

960-979	8223	CGCAGAGCUUGAGGACAGC	8224	CGcAGAGCUUGAGGAcAGCdTsdT	antis

966-985	8225	CUCAAGCUCUGCGAUUUUG	8226	cucAAGcucuGcGAuuuuGdTsdT	sense

966-985	8227	CAAAAUCGCAGAGCUUGAG	8228	cAAAAUCGcAGAGCUUGAGdTsdT	antis

982-1001	8229	UUGGCAGUGCAAAGCAGCU	8230	uuGGcAGuGcAAAGcAGcudTsdT	sense

982-1001	8231	AGCUGCUUUGCACUGCCAA	8232	AGCUGCUUUGcACUGCcAAdTsdT	antis

983-1002	8233	UGGCAGUGCAAAGCAGCUG	8234	uGGcAGuGcAAAGcAGcuGdTsdT	sense

983-1002	8235	CAGCUGCUUUGCACUGCCA	8236	cAGCUGCUUUGcACUGCcAdTsdT	antis

1170-1189	8237	GACCAGCUUGUGGAGAUCA	8238	GAccAGcuuGuGGAGAucAdTsdT	sense

1170-1189	8239	UGAUCUCCACAAGCUGGUC	8240	UGAUCUCcAcAAGCUGGUCdTsdT	antis

1210-1229	8241	CCAGGGAACAAAUCCGAGA	8242	ccAGGGAAcAAAuccGAGAdTsdT	sense

1210-1229	8243	UCUCGGAUUUGUUCCCUGG	8244	UCUCGGAUUUGUUCCCUGGdTsdT	antis

1521-1540	8245	CCUCACUUGAGGUCCCCAG	8246	ccucAcuuGAGGuccccAGdTsdT	sense

1521-1540	8247	CUGGGGACCUCAAGUGAGG	8248	CUGGGGACCUcAAGUGAGGdTsdT	antis

1533-1552	8249	UCCCCAGCAGGCCCUGCUU	8250	uccccAGcAGGcccuGcuudTsdT	sense

1533-1552	8251	AAGCAGGGCCUGCUGGGGA	8252	AAGcAGGGCCUGCUGGGGAdTsdT	antis

1534-1553	8253	CCCCAGCAGGCCCUGCUUC	8254	ccccAGcAGGcccuGcuucdTsdT	sense

1534-1553	8255	GAAGCAGGGCCUGCUGGGG	8256	GAAGcAGGGCCUGCUGGGGdTsdT	antis

1679-1698	8257	ACCCCUCCACGUCCAUCUG	8258	AccccuccAcGuccAucuGdTsdT	sense

1679-1698	8259	CAGAUGGACGUGGAGGGGU	8260	cAGAUGGACGUGGAGGGGUdTsdT	antis

1680-1699	8261	CCCCUCCACGUCCAUCUGG	8262	ccccuccAcGuccAucuGGdTsdT	sense

1680-1699	8263	CCAGAUGGACGUGGAGGGG	8264	CcAGAUGGACGUGGAGGGGdTsdT	antis

1684-1703	8265	UCCACGUCCAUCUGGGAAG	8266	uccAcGuccAucuGGGAAGdTsdT	sense

1684-1703	8267	CUUCCCAGAUGGACGUGGA	8268	CUUCCcAGAUGGACGUGGAdTsdT	antis

1710-1729	8269	UGGCGCUGGGAAGGGGGCC	8270	uGGcGcuGGGAAGGGGGccdTsdT	sense

1710-1729	8271	GGCCCCCUUCCCAGCGCCA	8272	GGCCCCCUUCCcAGCGCcAdTsdT	antis

1711-1730	8273	GGCGCUGGGAAGGGGGCCA	8274	GGcGcuGGGAAGGGGGccAdTsdT	sense

1711-1730	8275	UGGCCCCCUUCCCAGCGCC	8276	UGGCCCCCUUCCcAGCGCCdTsdT	antis

1726-1745	8277	GCCACAGCCCAUCAAGCUC	8278	GccAcAGcccAucAAGcucdTsdT	sense

1726-1745	8279	GAGCUUGAUGGGCUGUGGC	8280	GAGCUUGAUGGGCUGUGGCdTsdT	antis

1731-1750	8281	AGCCCAUCAAGCUCCUGCC	8282	AGcccAucAAGcuccuGccdTsdT	sense

1731-1750	8283	GGCAGGAGCUUGAUGGGCU	8284	GGcAGGAGCUUGAUGGGCUdTsdT	antis

1740-1759	8285	AGCUCCUGCCCUGGCUGGG	8286	AGcuccuGcccuGGcuGGGdTsdT	sense

1740-1759	8287	CCCAGCCAGGGCAGGAGCU	8288	CCcAGCcAGGGcAGGAGCUdTsdT	antis

1741-1760	8289	GCUCCUGCCCUGGCUGGGC	8290	GcuccuGcccuGGcuGGGcdTsdT	sense

1741-1760	8291	GCCCAGCCAGGGCAGGAGC	8292	GCCcAGCcAGGGcAGGAGCdTsdT	antis

1767-1786	8293	CUAGAGGGCAGAGGUAAAU	8294	cuAGAGGGcAGAGGuAAAudTsdT	sense

1767-1786	8295	AUUUACCUCUGCCCUCUAG	8296	AUUuACCUCUGCCCUCuAGdTsdT	antis

1772-1791	8297	GGGCAGAGGUAAAUGAACU	8298	GGGcAGAGGuAAAuGAAcudTsdT	sense

1772-1791	8299	AGUUCAUUUACCUCUGCCC	8300	AGUUcAUUuACCUCUGCCCdTsdT	antis

1775-1794	8301	CAGAGGUAAAUGAACUACC	8302	cAGAGGuAAAuGAAcuAccdTsdT	sense

1775-1794	8303	GGUAGUUCAUUUACCUCUG	8304	GGuAGUUcAUUuACCUCUGdTsdT	antis

1824-1843	8305	ACCUCUGUGGUGGGCUUUU	8306	AccucuGuGGuGGGcuuuudTsdT	sense

1824-1843	8307	AAAAGCCCACCACAGAGGU	8308	AAAAGCCcACcAcAGAGGUdTsdT	antis

1834-1853	8309	UGGGCUUUUUAAAGAGGAU	8310	uGGGcuuuuuAAAGAGGAudTsdT	sense

1834-1853	8311	AUCCUCUUUAAAAAGCCCA	8312	AUCCUCUUuAAAAAGCCcAdTsdT	antis

2015-2034	8313	UUCCCUUCCCUGGCCCCCU	8314	uucccuucccuGGcccccudTsdT	sense

2015-2034	8315	AGGGGGCCAGGGAAGGGAA	8316	AGGGGGCcAGGGAAGGGAAdTsdT	antis

69-88	8317	GGAGCCGGAGCCCGAACGG	8318	GGAGccGGAGcccGAAcGGdTsdT	sense

69-88	8319	CCGUUCGGGCUCCGGCUCC	8320	CCGUUCGGGCUCCGGCUCCdTsdT	antis

112-131	8321	CAGGGGAGGCGGCGGCAGA	8322	cAGGGGAGGcGGcGGcAGAdTsdT	sense

112-131	8323	UCUGCCGCCGCCUCCCCUG	8324	UCUGCCGCCGCCUCCCCUGdTsdT	antis

113-132	8325	AGGGGAGGCGGCGGCAGAG	8326	AGGGGAGGcGGcGGcAGAGdTsdT	sense

113-132	8327	CUCUGCCGCCGCCUCCCCU	8328	CUCUGCCGCCGCCUCCCCUdTsdT	antis

114-133	8329	GGGGAGGCGGCGGCAGAGG	8330	GGGGAGGcGGcGGcAGAGGdTsdT	sense

114-133	8331	CCUCUGCCGCCGCCUCCCC	8332	CCUCUGCCGCCGCCUCCCCdTsdT	antis

116-135	8333	GGAGGCGGCGGCAGAGGCA	8334	GGAGGcGGcGGcAGAGGcAdTsdT	sense

116-135	8335	UGCCUCUGCCGCCGCCUCC	8336	UGCCUCUGCCGCCGCCUCCdTsdT	antis

130-149	8337	AGGCAGCGGCGGGGGCAGC	8338	AGGcAGcGGcGGGGGcAGcdTsdT	sense

130-149	8339	GCUGCCCCCGCCGCUGCCU	8340	GCUGCCCCCGCCGCUGCCUdTsdT	antis

131-150	8341	GGCAGCGGCGGGGGCAGCC	8342	GGcAGcGGcGGGGGcAGccdTsdT	sense

131-150	8343	GGCUGCCCCCGCCGCUGCC	8344	GGCUGCCCCCGCCGCUGCCdTsdT	antis

166-185	8345	CGCGGCCUGGGCCUGCGCU	8346	cGcGGccuGGGccuGcGcudTsdT	sense

166-185	8347	AGCGCAGGCCCAGGCCGCG	8348	AGCGcAGGCCcAGGCCGCGdTsdT	antis

272-291	8349	CGGAGGCGGAGGUGGUGGC	8350	cGGAGGcGGAGGuGGuGGcdTsdT	sense

272-291	8351	GCCACCACCUCCGCCUCCG	8352	GCcACcACCUCCGCCUCCGdTsdT	antis

273-292	8353	GGAGGCGGAGGUGGUGGCG	8354	GGAGGcGGAGGuGGuGGcGdTsdT	sense

273-292	8355	CGCCACCACCUCCGCCUCC	8356	CGCcACcACCUCCGCCUCCdTsdT	antis

274-293	8357	GAGGCGGAGGUGGUGGCGG	8358	GAGGcGGAGGuGGuGGcGGdTsdT	sense

274-293	8359	CCGCCACCACCUCCGCCUC	8360	CCGCcACcACCUCCGCCUCdTsdT	antis

276-295	8361	GGCGGAGGUGGUGGCGGCG	8362	GGcGGAGGuGGuGGcGGcGdTsdT	sense

276-295	8363	CGCCGCCACCACCUCCGCC	8364	CGCCGCcACcACCUCCGCCdTsdT	antis

277-296	8365	GCGGAGGUGGUGGCGGCGG	8366	GcGGAGGuGGuGGcGGcGGdTsdT	sense

277-296	8367	CCGCCGCCACCACCUCCGC	8368	CCGCCGCcACcACCUCCGCdTsdT	antis

285-304	8369	GGUGGCGGCGGCCCCGGGG	8370	GGuGGcGGcGGccccGGGGdTsdT	sense

285-304	8371	CCCCGGGGCCGCCGCCACC	8372	CCCCGGGGCCGCCGCcACCdTsdT	antis

286-305	8373	GUGGCGGCGGCCCCGGGGG	8374	GuGGcGGcGGccccGGGGGdTsdT	sense

286-305	8375	CCCCCGGGGCCGCCGCCAC	8376	CCCCCGGGGCCGCCGCcACdTsdT	antis

287-306	8377	UGGCGGCGGCCCCGGGGGC	8378	uGGcGGcGGccccGGGGGcdTsdT	sense

287-306	8379	GCCCCCGGGGCCGCCGCCA	8380	GCCCCCGGGGCCGCCGCcAdTsdT	antis

288-307	8381	GGCGGCGGCCCCGGGGGCU	8382	GGcGGcGGccccGGGGGcudTsdT	sense

288-307	8383	AGCCCCCGGGGCCGCCGCC	8384	AGCCCCCGGGGCCGCCGCCdTsdT	antis

309-328	8385	GCCUCUGGCCCAGGAGGCA	8386	GccucuGGcccAGGAGGcAdTsdT	sense

309-328	8387	UGCCUCCUGGGCCAGAGGC	8388	UGCCUCCUGGGCcAGAGGCdTsdT	antis

310-329	8389	CCUCUGGCCCAGGAGGCAC	8390	ccucuGGcccAGGAGGcAcdTsdT	sense

310-329	8391	GUGCCUCCUGGGCCAGAGG	8392	GUGCCUCCUGGGCcAGAGGdTsdT	antis

312-331	8393	UCUGGCCCAGGAGGCACUG	8394	ucuGGcccAGGAGGcAcuGdTsdT	sense

312-331	8395	CAGUGCCUCCUGGGCCAGA	8396	cAGUGCCUCCUGGGCcAGAdTsdT	antis

313-332	8397	CUGGCCCAGGAGGCACUGG	8398	cuGGcccAGGAGGcAcuGGdTsdT	sense

313-332	8399	CCAGUGCCUCCUGGGCCAG	8400	CcAGUGCCUCCUGGGCcAGdTsdT	antis

315-334	8401	GGCCCAGGAGGCACUGGCG	8402	GGcccAGGAGGcAcuGGcGdTsdT	sense

315-334	8403	CGCCAGUGCCUCCUGGGCC	8404	CGCcAGUGCCUCCUGGGCCdTsdT	antis

356-375	8405	UAUGGGUGGGGGCGUGGGA	8406	uAuGGGuGGGGGcGuGGGAdTsdT	sense

356-375	8407	UCCCACGCCCCCACCCAUA	8408	UCCcACGCCCCcACCcAuAdTsdT	antis

359-378	8409	GGGUGGGGGCGUGGGAGCC	8410	GGGuGGGGGcGuGGGAGccdTsdT	sense

359-378	8411	GGCUCCCACGCCCCCACCC	8412	GGCUCCcACGCCCCcACCCdTsdT	antis

360-379	8413	GGUGGGGGCGUGGGAGCCU	8414	GGuGGGGGcGuGGGAGccudTsdT	sense

360-379	8415	AGGCUCCCACGCCCCCACC	8416	AGGCUCCcACGCCCCcACCdTsdT	antis

362-381	8417	UGGGGGCGUGGGAGCCUCG	8418	uGGGGGcGuGGGAGccucGdTsdT	sense

362-381	8419	CGAGGCUCCCACGCCCCCA	8420	CGAGGCUCCcACGCCCCcAdTsdT	antis

367-386	8421	GCGUGGGAGCCUCGAGCUC	8422	GcGuGGGAGccucGAGcucdTsdT	sense

367-386	8423	GAGCUCGAGGCUCCCACGC	8424	GAGCUCGAGGCUCCcACGCdTsdT	antis

401-420	8425	CGGCAGCGGCGGAGGAGGC	8426	cGGcAGcGGcGGAGGAGGcdTsdT	sense

401-420	8427	GCCUCCUCCGCCGCUGCCG	8428	GCCUCCUCCGCCGCUGCCGdTsdT	antis

402-421	8429	GGCAGCGGCGGAGGAGGCA	8430	GGcAGcGGcGGAGGAGGcAdTsdT	sense

402-421	8431	UGCCUCCUCCGCCGCUGCC	8432	UGCCUCCUCCGCCGCUGCCdTsdT	antis

409-428	8433	GCGGAGGAGGCAGCGGUGG	8434	GcGGAGGAGGcAGcGGuGGdTsdT	sense

409-428	8435	CCACCGCUGCCUCCUCCGC	8436	CcACCGCUGCCUCCUCCGCdTsdT	antis

410-429	8437	CGGAGGAGGCAGCGGUGGC	8438	cGGAGGAGGcAGcGGuGGcdTsdT	sense

410-429	8439	GCCACCGCUGCCUCCUCCG	8440	GCcACCGCUGCCUCCUCCGdTsdT	antis

415-434	8441	GAGGCAGCGGUGGCCCCGG	8442	GAGGcAGcGGuGGccccGGdTsdT	sense

415-434	8443	CCGGGGCCACCGCUGCCUC	8444	CCGGGGCcACCGCUGCCUCdTsdT	antis

416-435	8445	AGGCAGCGGUGGCCCCGGC	8446	AGGcAGcGGuGGccccGGcdTsdT	sense

416-435	8447	GCCGGGGCCACCGCUGCCU	8448	GCCGGGGCcACCGCUGCCUdTsdT	antis

483-502	8449	GGGAAGGUGACCACAGUGG	8450	GGGAAGGuGAccAcAGuGGdTsdT	sense

483-502	8451	CCACUGUGGUCACCUUCCC	8452	CcACUGUGGUcACCUUCCCdTsdT	antis

484-503	8453	GGAAGGUGACCACAGUGGU	8454	GGAAGGuGAccAcAGuGGudTsdT	sense

484-503	8455	ACCACUGUGGUCACCUUCC	8456	ACcACUGUGGUcACCUUCCdTsdT	antis

486-505	8457	AAGGUGACCACAGUGGUAG	8458	AAGGuGAccAcAGuGGuAGdTsdT	sense

486-505	8459	CUACCACUGUGGUCACCUU	8460	CuACcACUGUGGUcACCUUdTsdT	antis

529-548	8461	GUUCCCAAGAAGUGGCUUA	8462	GuucccAAGAAGuGGcuuAdTsdT	sense

529-548	8463	UAAGCCACUUCUUGGGAAC	8464	uAAGCcACUUCUUGGGAACdTsdT	antis

560-579	8465	AGUGAUUGGUAAUGGCUCA	8466	AGuGAuuGGuAAuGGcucAdTsdT	sense

560-579	8467	UGAGCCAUUACCAAUCACU	8468	UGAGCcAUuACcAAUcACUdTsdT	antis

561-580	8469	GUGAUUGGUAAUGGCUCAU	8470	GuGAuuGGuAAuGGcucAudTsdT	sense

561-580	8471	AUGAGCCAUUACCAAUCAC	8472	AUGAGCcAUuACcAAUcACdTsdT	antis

622-641	8473	UGGUGGCCAUCAAGAAGGU	8474	uGGuGGccAucAAGAAGGudTsdT	sense

622-641	8475	ACCUUCUUGAUGGCCACCA	8476	ACCUUCUUGAUGGCcACcAdTsdT	antis

628-647	8477	CCAUCAAGAAGGUUCUUCA	8478	ccAucAAGAAGGuucuucAdTsdT	sense

628-647	8479	UGAAGAACCUUCUUGAUGG	8480	UGAAGAACCUUCUUGAUGGdTsdT	antis

629-648	8481	CAUCAAGAAGGUUCUUCAG	8482	cAucAAGAAGGuucuucAGdTsdT	sense

629-648	8483	CUGAAGAACCUUCUUGAUG	8484	CUGAAGAACCUUCUUGAUGdTsdT	antis

637-656	8485	AGGUUCUUCAGGACAAAAG	8486	AGGuucuucAGGAcAAAAGdTsdT	sense

637-656	8487	CUUUUGUCCUGAAGAACCU	8488	CUUUUGUCCUGAAGAACCUdTsdT	antis

684-703	8489	CGUAAGCUGGACCACUGCA	8490	cGuAAGcuGGAccAcuGcAdTsdT	sense

684-703	8491	UGCAGUGGUCCAGCUUACG	8492	UGcAGUGGUCcAGCUuACGdTsdT	antis

695-714	8493	CCACUGCAAUAUUGUGAGG	8494	ccAcuGcAAuAuuGuGAGGdTsdT	sense

695-714	8495	CCUCACAAUAUUGCAGUGG	8496	CCUcAcAAuAUUGcAGUGGdTsdT	antis

719-738	8497	GUACUUUUUCUACUCCAGU	8498	GuAcuuuuucuAcuccAGudTsdT	sense

719-738	8499	ACUGGAGUAGAAAAAGUAC	8500	ACUGGAGuAGAAAAAGuACdTsdT	antis

722-741	8501	CUUUUUCUACUCCAGUGGG	8502	cuuuuucuAcuccAGuGGGdTsdT	sense

722-741	8503	CCCACUGGAGUAGAAAAAG	8504	CCcACUGGAGuAGAAAAAGdTsdT	antis

728-747	8505	CUACUCCAGUGGGGAGAAG	8506	cuAcuccAGuGGGGAGAAGdTsdT	sense

728-747	8507	CUUCUCCCCACUGGAGUAG	8508	CUUCUCCCcACUGGAGuAGdTsdT	antis

732-751	8509	UCCAGUGGGGAGAAGAAGG	8510	uccAGuGGGGAGAAGAAGGdTsdT	sense

732-751	8511	CCUUCUUCUCCCCACUGGA	8512	CCUUCUUCUCCCcACUGGAdTsdT	antis

734-753	8513	CAGUGGGGAGAAGAAGGAC	8514	cAGuGGGGAGAAGAAGGAcdTsdT	sense

734-753	8515	GUCCUUCUUCUCCCCACUG	8516	GUCCUUCUUCUCCCcACUGdTsdT	antis

735-754	8517	AGUGGGGAGAAGAAGGACG	8518	AGuGGGGAGAAGAAGGAcGdTsdT	sense

735-754	8519	CGUCCUUCUUCUCCCCACU	8520	CGUCCUUCUUCUCCCcACUdTsdT	antis

766-785	8521	AUCUGGUGCUGGAGUAUGU	8522	AucuGGuGcuGGAGuAuGudTsdT	sense

766-785	8523	ACAUACUCCAGCACCAGAU	8524	AcAuACUCcAGcACcAGAUdTsdT	antis

767-786	8525	UCUGGUGCUGGAGUAUGUG	8526	ucuGGuGcuGGAGuAuGuGdTsdT	sense

767-786	8527	CACAUACUCCAGCACCAGA	8528	cAcAuACUCcAGcACcAGAdTsdT	antis

768-787	8529	CUGGUGCUGGAGUAUGUGC	8530	cuGGuGcuGGAGuAuGuGcdTsdT	sense

768-787	8531	GCACAUACUCCAGCACCAG	8532	GcAcAuACUCcAGcACcAGdTsdT	antis

812-831	8533	CCACUUCACCAAGGCCAAG	8534	ccAcuucAccAAGGccAAGdTsdT	sense

812-831	8535	CUUGGCCUUGGUGAAGUGG	8536	CUUGGCCUUGGUGAAGUGGdTsdT	antis

814-833	8537	ACUUCACCAAGGCCAAGCU	8538	AcuucAccAAGGccAAGcudTsdT	sense

814-833	8539	AGCUUGGCCUUGGUGAAGU	8540	AGCUUGGCCUUGGUGAAGUdTsdT	antis

816-835	8541	UUCACCAAGGCCAAGCUGA	8542	uucAccAAGGccAAGcuGAdTsdT	sense

816-835	8543	UCAGCUUGGCCUUGGUGAA	8544	UcAGCUUGGCCUUGGUGAAdTsdT	antis

819-838	8545	ACCAAGGCCAAGCUGAUCA	8546	AccAAGGccAAGcuGAucAdTsdT	sense

819-838	8547	UGAUCAGCUUGGCCUUGGU	8548	UGAUcAGCUUGGCCUUGGUdTsdT	antis

820-839	8549	CCAAGGCCAAGCUGAUCAC	8550	ccAAGGccAAGcuGAucAcdTsdT	sense

820-839	8551	GUGAUCAGCUUGGCCUUGG	8552	GUGAUcAGCUUGGCCUUGGdTsdT	antis

864-883	8553	AUGUACCAGCUCUUCCGGA	8554	AuGuAccAGcucuuccGGAdTsdT	sense

864-883	8555	UCCGGAAGAGCUGGUACAU	8556	UCCGGAAGAGCUGGuAcAUdTsdT	antis

875-894	8557	CUUCCGGAGCUUGGCCUAC	8558	cuuccGGAGcuuGGccuAcdTsdT	sense

875-894	8559	GUAGGCCAAGCUCCGGAAG	8560	GuAGGCcAAGCUCCGGAAGdTsdT	antis

964-983	8561	UCCUCAAGCUCUGCGAUUU	8562	uccucAAGcucuGcGAuuudTsdT	sense

964-983	8563	AAAUCGCAGAGCUUGAGGA	8564	AAAUCGcAGAGCUUGAGGAdTsdT	antis

965-984	8565	CCUCAAGCUCUGCGAUUUU	8566	ccucAAGcucuGcGAuuuudTsdT	sense

965-984	8567	AAAAUCGCAGAGCUUGAGG	8568	AAAAUCGcAGAGCUUGAGGdTsdT	antis

969-988	8569	AAGCUCUGCGAUUUUGGCA	8570	AAGcucuGcGAuuuuGGcAdTsdT	sense

969-988	8571	UGCCAAAAUCGCAGAGCUU	8572	UGCcAAAAUCGcAGAGCUUdTsdT	antis

980-999	8573	UUUUGGCAGUGCAAAGCAG	8574	uuuuGGcAGuGcAAAGcAGdTsdT	sense

980-999	8575	CUGCUUUGCACUGCCAAAA	8576	CUGCUUUGcACUGCcAAAAdTsdT	antis

981-1000	8577	UUUGGCAGUGCAAAGCAGC	8578	uuuGGcAGuGcAAAGcAGcdTsdT	sense

981-1000	8579	GCUGCUUUGCACUGCCAAA	8580	GCUGCUUUGcACUGCcAAAdTsdT	antis

985-1004	8581	GCAGUGCAAAGCAGCUGGU	8582	GcAGuGcAAAGcAGcuGGudTsdT	sense

985-1004	8583	ACCAGCUGCUUUGCACUGC	8584	ACcAGCUGCUUUGcACUGCdTsdT	antis

1166-1185	8585	GGUGGACCAGCUUGUGGAG	8586	GGuGGAccAGcuuGuGGAGdTsdT	sense

1166-1185	8587	CUCCACAAGCUGGUCCACC	8588	CUCcAcAAGCUGGUCcACCdTsdT	antis

1167-1186	8589	GUGGACCAGCUUGUGGAGA	8590	GuGGAccAGcuuGuGGAGAdTsdT	sense

1167-1186	8591	UCUCCACAAGCUGGUCCAC	8592	UCUCcAcAAGCUGGUCcACdTsdT	antis

1171-1190	8593	ACCAGCUUGUGGAGAUCAU	8594	AccAGcuuGuGGAGAucAudTsdT	sense

1171-1190	8595	AUGAUCUCCACAAGCUGGU	8596	AUGAUCUCcAcAAGCUGGUdTsdT	antis

1211-1230	8597	CAGGGAACAAAUCCGAGAG	8598	cAGGGAAcAAAuccGAGAGdTsdT	sense

1211-1230	8599	CUCUCGGAUUUGUUCCCUG	8600	CUCUCGGAUUUGUUCCCUGdTsdT	antis

1254-1273	8601	AAGUUCCCCCAGAUCAAAG	8602	AAGuucccccAGAucAAAGdTsdT	sense

1254-1273	8603	CUUUGAUCUGGGGGAACUU	8604	CUUUGAUCUGGGGGAACUUdTsdT	antis

1259-1278	8605	CCCCCAGAUCAAAGCUCAC	8606	cccccAGAucAAAGcucAcdTsdT	sense

1259-1278	8607	GUGAGCUUUGAUCUGGGGG	8608	GUGAGCUUUGAUCUGGGGGdTsdT	antis

1260-1279	8609	CCCCAGAUCAAAGCUCACC	8610	ccccAGAucAAAGcucAccdTsdT	sense

1260-1279	8611	GGUGAGCUUUGAUCUGGGG	8612	GGUGAGCUUUGAUCUGGGGdTsdT	antis

1281-1300	8613	UGGACAAAGGUGUUCAAAU	8614	uGGAcAAAGGuGuucAAAudTsdT	sense

1281-1300	8615	AUUUGAACACCUUUGUCCA	8616	AUUUGAAcACCUUUGUCcAdTsdT	antis

1360-1379	8617	CCUCAAGGCUCUCCCCACU	8618	ccucAAGGcucuccccAcudTsdT	sense

1360-1379	8619	AGUGGGGAGAGCCUUGAGG	8620	AGUGGGGAGAGCCUUGAGGdTsdT	antis

1381-1400	8621	AGGCUUGUGCCCACAGCUU	8622	AGGcuuGuGcccAcAGcuudTsdT	sense

1381-1400	8623	AAGCUGUGGGCACAAGCCU	8624	AAGCUGUGGGcAcAAGCCUdTsdT	antis

1385-1404	8625	UUGUGCCCACAGCUUCUUC	8626	uuGuGcccAcAGcuucuucdTsdT	sense

1385-1404	8627	GAAGAAGCUGUGGGCACAA	8628	GAAGAAGCUGUGGGcAcAAdTsdT	antis

1387-1406	8629	GUGCCCACAGCUUCUUCGA	8630	GuGcccAcAGcuucuucGAdTsdT	sense

1387-1406	8631	UCGAAGAAGCUGUGGGCAC	8632	UCGAAGAAGCUGUGGGcACdTsdT	antis

1388-1407	8633	UGCCCACAGCUUCUUCGAU	8634	uGcccAcAGcuucuucGAudTsdT	sense

1388-1407	8635	AUCGAAGAAGCUGUGGGCA	8636	AUCGAAGAAGCUGUGGGcAdTsdT	antis

1455-1474	8637	CCCCUGUUCAACUUCAGUC	8638	ccccuGuucAAcuucAGucdTsdT	sense

1455-1474	8639	GACUGAAGUUGAACAGGGG	8640	GACUGAAGUUGAAcAGGGGdTsdT	antis

1456-1475	8641	CCCUGUUCAACUUCAGUCC	8642	cccuGuucAAcuucAGuccdTsdT	sense

1456-1475	8643	GGACUGAAGUUGAACAGGG	8644	GGACUGAAGUUGAAcAGGGdTsdT	antis

1457-1476	8645	CCUGUUCAACUUCAGUCCU	8646	ccuGuucAAcuucAGuccudTsdT	sense

1457-1476	8647	AGGACUGAAGUUGAACAGG	8648	AGGACUGAAGUUGAAcAGGdTsdT	antis

1458-1477	8649	CUGUUCAACUUCAGUCCUG	8650	cuGuucAAcuucAGuccuGdTsdT	sense

1458-1477	8651	CAGGACUGAAGUUGAACAG	8652	cAGGACUGAAGUUGAAcAGdTsdT	antis

1513-1532	8653	UCAUCCCUCCUCACUUGAG	8654	ucAucccuccucAcuuGAGdTsdT	sense

1513-1532	8655	CUCAAGUGAGGAGGGAUGA	8656	CUcAAGUGAGGAGGGAUGAdTsdT	antis

1514-1533	8657	CAUCCCUCCUCACUUGAGG	8658	cAucccuccucAcuuGAGGdTsdT	sense

1514-1533	8659	CCUCAAGUGAGGAGGGAUG	8660	CCUcAAGUGAGGAGGGAUGdTsdT	antis

1517-1536	8661	CCCUCCUCACUUGAGGUCC	8662	cccuccucAcuuGAGGuccdTsdT	sense

1517-1536	8663	GGACCUCAAGUGAGGAGGG	8664	GGACCUcAAGUGAGGAGGGdTsdT	antis

1518-1537	8665	CCUCCUCACUUGAGGUCCC	8666	ccuccucAcuuGAGGucccdTsdT	sense

1518-1537	8667	GGGACCUCAAGUGAGGAGG	8668	GGGACCUcAAGUGAGGAGGdTsdT	antis

1519-1538	8669	CUCCUCACUUGAGGUCCCC	8670	cuccucAcuuGAGGuccccdTsdT	sense

1519-1538	8671	GGGGACCUCAAGUGAGGAG	8672	GGGGACCUcAAGUGAGGAGdTsdT	antis

1525-1544	8673	ACUUGAGGUCCCCAGCAGG	8674	AcuuGAGGuccccAGcAGGdTsdT	sense

1525-1544	8675	CCUGCUGGGGACCUCAAGU	8676	CCUGCUGGGGACCUcAAGUdTsdT	antis

1526-1545	8677	CUUGAGGUCCCCAGCAGGC	8678	cuuGAGGuccccAGcAGGcdTsdT	sense

1526-1545	8679	GCCUGCUGGGGACCUCAAG	8680	GCCUGCUGGGGACCUcAAGdTsdT	antis

1527-1546	8681	UUGAGGUCCCCAGCAGGCC	8682	uuGAGGuccccAGcAGGccdTsdT	sense

1527-1546	8683	GGCCUGCUGGGGACCUCAA	8684	GGCCUGCUGGGGACCUcAAdTsdT	antis

1530-1549	8685	AGGUCCCCAGCAGGCCCUG	8686	AGGuccccAGcAGGcccuGdTsdT	sense

1530-1549	8687	CAGGGCCUGCUGGGGACCU	8688	cAGGGCCUGCUGGGGACCUdTsdT	antis

1531-1550	8689	GGUCCCCAGCAGGCCCUGC	8690	GGuccccAGcAGGcccuGcdTsdT	sense

1531-1550	8691	GCAGGGCCUGCUGGGGACC	8692	GcAGGGCCUGCUGGGGACCdTsdT	antis

1532-1551	8693	GUCCCCAGCAGGCCCUGCU	8694	GuccccAGcAGGcccuGcudTsdT	sense

1532-1551	8695	AGCAGGGCCUGCUGGGGAC	8696	AGcAGGGCCUGCUGGGGACdTsdT	antis

1538-1557	8697	AGCAGGCCCUGCUUCUCCC	8698	AGcAGGcccuGcuucucccdTsdT	sense

1538-1557	8699	GGGAGAAGCAGGGCCUGCU	8700	GGGAGAAGcAGGGCCUGCUdTsdT	antis

1588-1607	8701	CUUUAACUGAAGCUCAGAC	8702	cuuuAAcuGAAGcucAGAcdTsdT	sense

1588-1607	8703	GUCUGAGCUUCAGUUAAAG	8704	GUCUGAGCUUcAGUuAAAGdTsdT	antis

1626-1645	8705	UCUGAUGCCACAACUGCUA	8706	ucuGAuGccAcAAcuGcuAdTsdT	sense

1626-1645	8707	UAGCAGUUGUGGCAUCAGA	8708	uAGcAGUUGUGGcAUcAGAdTsdT	antis

1627-1646	8709	CUGAUGCCACAACUGCUAC	8710	cuGAuGccAcAAcuGcuAcdTsdT	sense

1627-1646	8711	GUAGCAGUUGUGGCAUCAG	8712	GuAGcAGUUGUGGcAUcAGdTsdT	antis

1628-1647	8713	UGAUGCCACAACUGCUACC	8714	uGAuGccAcAAcuGcuAccdTsdT	sense

1628-1647	8715	GGUAGCAGUUGUGGCAUCA	8716	GGuAGcAGUUGUGGcAUcAdTsdT	antis

1629-1648	8717	GAUGCCACAACUGCUACCC	8718	GAuGccAcAAcuGcuAcccdTsdT	sense

1629-1648	8719	GGGUAGCAGUUGUGGCAUC	8720	GGGuAGcAGUUGUGGcAUCdTsdT	antis

1686-1705	8721	CACGUCCAUCUGGGAAGGC	8722	cAcGuccAucuGGGAAGGcdTsdT	sense

1686-1705	8723	GCCUUCCCAGAUGGACGUG	8724	GCCUUCCcAGAUGGACGUGdTsdT	antis

1687-1706	8725	ACGUCCAUCUGGGAAGGCC	8726	AcGuccAucuGGGAAGGccdTsdT	sense

1687-1706	8727	GGCCUUCCCAGAUGGACGU	8728	GGCCUUCCcAGAUGGACGUdTsdT	antis

1688-1707	8729	CGUCCAUCUGGGAAGGCCC	8730	cGuccAucuGGGAAGGcccdTsdT	sense

1688-1707	8731	GGGCCUUCCCAGAUGGACG	8732	GGGCCUUCCcAGAUGGACGdTsdT	antis

1689-1708	8733	GUCCAUCUGGGAAGGCCCA	8734	GuccAucuGGGAAGGcccAdTsdT	sense

1689-1708	8735	UGGGCCUUCCCAGAUGGAC	8736	UGGGCCUUCCcAGAUGGACdTsdT	antis

1694-1713	8737	UCUGGGAAGGCCCAAGUGG	8738	ucuGGGAAGGcccAAGuGGdTsdT	sense

1694-1713	8739	CCACUUGGGCCUUCCCAGA	8740	CcACUUGGGCCUUCCcAGAdTsdT	antis

1695-1714	8741	CUGGGAAGGCCCAAGUGGC	8742	cuGGGAAGGcccAAGuGGcdTsdT	sense

1695-1714	8743	GCCACUUGGGCCUUCCCAG	8744	GCcACUUGGGCCUUCCcAGdTsdT	antis

1709-1728	8745	GUGGCGCUGGGAAGGGGGC	8746	GuGGcGcuGGGAAGGGGGcdTsdT	sense

1709-1728	8747	GCCCCCUUCCCAGCGCCAC	8748	GCCCCCUUCCcAGCGCcACdTsdT	antis

1714-1733	8749	GCUGGGAAGGGGGCCACAG	8750	GcuGGGAAGGGGGccAcAGdTsdT	sense

1714-1733	8751	CUGUGGCCCCCUUCCCAGC	8752	CUGUGGCCCCCUUCCcAGCdTsdT	antis

1722-1741	8753	GGGGGCCACAGCCCAUCAA	8754	GGGGGccAcAGcccAucAAdTsdT	sense

1722-1741	8755	UUGAUGGGCUGUGGCCCCC	8756	UUGAUGGGCUGUGGCCCCCdTsdT	antis

1723-1742	8757	GGGGCCACAGCCCAUCAAG	8758	GGGGccAcAGcccAucAAGdTsdT	sense

1723-1742	8759	CUUGAUGGGCUGUGGCCCC	8760	CUUGAUGGGCUGUGGCCCCdTsdT	antis

1732-1751	8761	GCCCAUCAAGCUCCUGCCC	8762	GcccAucAAGcuccuGcccdTsdT	sense

1732-1751	8763	GGGCAGGAGCUUGAUGGGC	8764	GGGcAGGAGCUUGAUGGGCdTsdT	antis

1737-1756	8765	UCAAGCUCCUGCCCUGGCU	8766	ucAAGcuccuGcccuGGcudTsdT	sense

1737-1756	8767	AGCCAGGGCAGGAGCUUGA	8768	AGCcAGGGcAGGAGCUUGAdTsdT	antis

1743-1762	8769	UCCUGCCCUGGCUGGGCCC	8770	uccuGcccuGGcuGGGcccdTsdT	sense

1743-1762	8771	GGGCCCAGCCAGGGCAGGA	8772	GGGCCcAGCcAGGGcAGGAdTsdT	antis

1744-1763	8773	CCUGCCCUGGCUGGGCCCC	8774	ccuGcccuGGcuGGGccccdTsdT	sense

1744-1763	8775	GGGGCCCAGCCAGGGCAGG	8776	GGGGCCcAGCcAGGGcAGGdTsdT	antis

1746-1765	8777	UGCCCUGGCUGGGCCCCUA	8778	uGcccuGGcuGGGccccuAdTsdT	sense

1746-1765	8779	UAGGGGCCCAGCCAGGGCA	8780	uAGGGGCCcAGCcAGGGcAdTsdT	antis

1748-1767	8781	CCCUGGCUGGGCCCCUAGA	8782	cccuGGcuGGGccccuAGAdTsdT	sense

1748-1767	8783	UCUAGGGGCCCAGCCAGGG	8784	UCuAGGGGCCcAGCcAGGGdTsdT	antis

1769-1788	8785	AGAGGGCAGAGGUAAAUGA	8786	AGAGGGcAGAGGuAAAuGAdTsdT	sense

1769-1788	8787	UCAUUUACCUCUGCCCUCU	8788	UcAUUuACCUCUGCCCUCUdTsdT	antis

1770-1789	8789	GAGGGCAGAGGUAAAUGAA	8790	GAGGGcAGAGGuAAAuGAAdTsdT	sense

1770-1789	8791	UUCAUUUACCUCUGCCCUC	8792	UUcAUUuACCUCUGCCCUCdTsdT	antis

1798-1817	8793	GCAUCUAGGCCUCCCUCAG	8794	GcAucuAGGccucccucAGdTsdT	sense

1798-1817	8795	CUGAGGGAGGCCUAGAUGC	8796	CUGAGGGAGGCCuAGAUGCdTsdT	antis

1825-1844	8797	CCUCUGUGGUGGGCUUUUU	8798	ccucuGuGGuGGGcuuuuudTsdT	sense

1825-1844	8799	AAAAAGCCCACCACAGAGG	8800	AAAAAGCCcACcAcAGAGGdTsdT	antis

1831-1850	8801	UGGUGGGCUUUUUAAAGAG	8802	uGGuGGGcuuuuuAAAGAGdTsdT	sense

1831-1850	8803	CUCUUUAAAAAGCCCACCA	8804	CUCUUuAAAAAGCCcACcAdTsdT	antis

1833-1852	8805	GUGGGCUUUUUAAAGAGGA	8806	GuGGGcuuuuuAAAGAGGAdTsdT	sense

1833-1852	8807	UCCUCUUUAAAAAGCCCAC	8808	UCCUCUUuAAAAAGCCcACdTsdT	antis

1837-1856	8809	GCUUUUUAAAGAGGAUUUU	8810	GcuuuuuAAAGAGGAuuuudTsdT	sense

1837-1856	8811	AAAAUCCUCUUUAAAAAGC	8812	AAAAUCCUCUUuAAAAAGCdTsdT	antis

1838-1857	8813	CUUUUUAAAGAGGAUUUUA	8814	cuuuuuAAAGAGGAuuuuAdTsdT	sense

1838-1857	8815	UAAAAUCCUCUUUAAAAAG	8816	uAAAAUCCUCUUuAAAAAGdTsdT	antis

1869-1888	8817	GGAGGGGAGAAAAGGAAGG	8818	GGAGGGGAGAAAAGGAAGGdTsdT	sense

1869-1888	8819	CCUUCCUUUUCUCCCCUCC	8820	CCUUCCUUUUCUCCCCUCCdTsdT	antis

1870-1889	8821	GAGGGGAGAAAAGGAAGGA	8822	GAGGGGAGAAAAGGAAGGAdTsdT	sense

1870-1889	8823	UCCUUCCUUUUCUCCCCUC	8824	UCCUUCCUUUUCUCCCCUCdTsdT	antis

1888-1907	8825	ACGGGGUUUGGGGGUGUGA	8826	AcGGGGuuuGGGGGuGuGAdTsdT	sense

1888-1907	8827	UCACACCCCCAAACCCCGU	8828	UcAcACCCCcAAACCCCGUdTsdT	antis

1923-1942	8829	UGGUCCCCUCCCCUCCCCC	8830	uGGuccccuccccucccccdTsdT	sense

1923-1942	8831	GGGGGAGGGGAGGGGACCA	8832	GGGGGAGGGGAGGGGACcAdTsdT	antis

1924-1943	8833	GGUCCCCUCCCCUCCCCCA	8834	GGuccccuccccucccccAdTsdT	sense

1924-1943	8835	UGGGGGAGGGGAGGGGACC	8836	UGGGGGAGGGGAGGGGACCdTsdT	antis

1931-1950	8837	UCCCCUCCCCCAGGCUACC	8838	uccccucccccAGGcuAccdTsdT	sense

1931-1950	8839	GGUAGCCUGGGGGAGGGGA	8840	GGuAGCCUGGGGGAGGGGAdTsdT	antis

1962-1981	8841	CCCCCCUCUCCCAGGUCCC	8842	ccccccucucccAGGucccdTsdT	sense

1962-1981	8843	GGGACCUGGGAGAGGGGGG	8844	GGGACCUGGGAGAGGGGGGdTsdT	antis

1963-1982	8845	CCCCCUCUCCCAGGUCCCU	8846	cccccucucccAGGucccudTsdT	sense

1963-1982	8847	AGGGACCUGGGAGAGGGGG	8848	AGGGACCUGGGAGAGGGGGdTsdT	antis

2132-2151	8849	CCAAGGCUUCCUCCCUCUC	8850	ccAAGGcuuccucccucucdTsdT	sense

2132-2151	8851	GAGAGGGAGGAAGCCUUGG	8852	GAGAGGGAGGAAGCCUUGGdTsdT	antis

2139-2158	8853	UUCCUCCCUCUCCCCAUCC	8854	uuccucccucuccccAuccdTsdT	sense

2139-2158	8855	GGAUGGGGAGAGGGAGGAA	8856	GGAUGGGGAGAGGGAGGAAdTsdT	antis

63-82	8857	UGGGCCGGAGCCGGAGCCC	8858	uGGGccGGAGccGGAGcccdTsdT	sense

63-82	8859	GGGCUCCGGCUCCGGCCCA	8860	GGGCUCCGGCUCCGGCCcAdTsdT	antis

65-84	8861	GGCCGGAGCCGGAGCCCGA	8862	GGccGGAGccGGAGcccGAdTsdT	sense

65-84	8863	UCGGGCUCCGGCUCCGGCC	8864	UCGGGCUCCGGCUCCGGCCdTsdT	antis

66-85	8865	GCCGGAGCCGGAGCCCGAA	8866	GccGGAGccGGAGcccGAAdTsdT	sense

66-85	8867	UUCGGGCUCCGGCUCCGGC	8868	UUCGGGCUCCGGCUCCGGCdTsdT	antis

115-134	8869	GGGAGGCGGCGGCAGAGGC	8870	GGGAGGcGGcGGcAGAGGcdTsdT	sense

115-134	8871	GCCUCUGCCGCCGCCUCCC	8872	GCCUCUGCCGCCGCCUCCCdTsdT	antis

118-137	8873	AGGCGGCGGCAGAGGCAGC	8874	AGGcGGcGGcAGAGGcAGcdTsdT	sense

118-137	8875	GCUGCCUCUGCCGCCGCCU	8876	GCUGCCUCUGCCGCCGCCUdTsdT	antis

119-138	8877	GGCGGCGGCAGAGGCAGCG	8878	GGcGGcGGcAGAGGcAGcGdTsdT	sense

119-138	8879	CGCUGCCUCUGCCGCCGCC	8880	CGCUGCCUCUGCCGCCGCCdTsdT	antis

128-147	8881	AGAGGCAGCGGCGGGGGCA	8882	AGAGGcAGcGGcGGGGGcAdTsdT	sense

128-147	8883	UGCCCCCGCCGCUGCCUCU	8884	UGCCCCCGCCGCUGCCUCUdTsdT	antis

129-148	8885	GAGGCAGCGGCGGGGGCAG	8886	GAGGcAGcGGcGGGGGcAGdTsdT	sense

129-148	8887	CUGCCCCCGCCGCUGCCUC	8888	CUGCCCCCGCCGCUGCCUCdTsdT	antis

265-284	8889	CAGGAGGCGGAGGCGGAGG	8890	cAGGAGGcGGAGGcGGAGGdTsdT	sense

265-284	8891	CCUCCGCCUCCGCCUCCUG	8892	CCUCCGCCUCCGCCUCCUGdTsdT	antis

266-285	8893	AGGAGGCGGAGGCGGAGGU	8894	AGGAGGcGGAGGcGGAGGudTsdT	sense

266-285	8895	ACCUCCGCCUCCGCCUCCU	8896	ACCUCCGCCUCCGCCUCCUdTsdT	antis

269-288	8897	AGGCGGAGGCGGAGGUGGU	8898	AGGcGGAGGcGGAGGuGGudTsdT	sense

269-288	8899	ACCACCUCCGCCUCCGCCU	8900	ACcACCUCCGCCUCCGCCUdTsdT	antis

275-294	8901	AGGCGGAGGUGGUGGCGGC	8902	AGGcGGAGGuGGuGGcGGcdTsdT	sense

275-294	8903	GCCGCCACCACCUCCGCCU	8904	GCCGCcACcACCUCCGCCUdTsdT	antis

278-297	8905	CGGAGGUGGUGGCGGCGGC	8906	cGGAGGuGGuGGcGGcGGcdTsdT	sense

278-297	8907	GCCGCCGCCACCACCUCCG	8908	GCCGCCGCcACcACCUCCGdTsdT	antis

279-298	8909	GGAGGUGGUGGCGGCGGCC	8910	GGAGGuGGuGGcGGcGGccdTsdT	sense

279-298	8911	GGCCGCCGCCACCACCUCC	8912	GGCCGCCGCcACcACCUCCdTsdT	antis

314-333	8913	UGGCCCAGGAGGCACUGGC	8914	uGGcccAGGAGGcAcuGGcdTsdT	sense

314-333	8915	GCCAGUGCCUCCUGGGCCA	8916	GCcAGUGCCUCCUGGGCcAdTsdT	antis

399-418	8917	AGCGGCAGCGGCGGAGGAG	8918	AGcGGcAGcGGcGGAGGAGdTsdT	sense

399-418	8919	CUCCUCCGCCGCUGCCGCU	8920	CUCCUCCGCCGCUGCCGCUdTsdT	antis

411-430	8921	GGAGGAGGCAGCGGUGGCC	8922	GGAGGAGGcAGcGGuGGccdTsdT	sense

411-430	8923	GGCCACCGCUGCCUCCUCC	8924	GGCcACCGCUGCCUCCUCCdTsdT	antis

412-431	8925	GAGGAGGCAGCGGUGGCCC	8926	GAGGAGGcAGcGGuGGcccdTsdT	sense

412-431	8927	GGGCCACCGCUGCCUCCUC	8928	GGGCcACCGCUGCCUCCUCdTsdT	antis

413-432	8929	AGGAGGCAGCGGUGGCCCC	8930	AGGAGGcAGcGGuGGccccdTsdT	sense

413-432	8931	GGGGCCACCGCUGCCUCCU	8932	GGGGCcACCGCUGCCUCCUdTsdT	antis

414-433	8933	GGAGGCAGCGGUGGCCCCG	8934	GGAGGcAGcGGuGGccccGdTsdT	sense

414-433	8935	CGGGGCCACCGCUGCCUCC	8936	CGGGGCcACCGCUGCCUCCdTsdT	antis

636-655	8937	AAGGUUCUUCAGGACAAAA	8938	AAGGuucuucAGGAcAAAAdTsdT	sense

636-655	8939	UUUUGUCCUGAAGAACCUU	8940	UUUUGUCCUGAAGAACCUUdTsdT	antis

731-750	8941	CUCCAGUGGGGAGAAGAAG	8942	cuccAGuGGGGAGAAGAAGdTsdT	sense

731-750	8943	CUUCUUCUCCCCACUGGAG	8944	CUUCUUCUCCCcACUGGAGdTsdT	antis

733-752	8945	CCAGUGGGGAGAAGAAGGA	8946	ccAGuGGGGAGAAGAAGGAdTsdT	sense

733-752	8947	UCCUUCUUCUCCCCACUGG	8948	UCCUUCUUCUCCCcACUGGdTsdT	antis

963-982	8949	GUCCUCAAGCUCUGCGAUU	8950	GuccucAAGcucuGcGAuudTsdT	sense

963-982	8951	AAUCGCAGAGCUUGAGGAC	8952	AAUCGcAGAGCUUGAGGACdTsdT	antis

1535-1554	8953	CCCAGCAGGCCCUGCUUCU	8954	cccAGcAGGcccuGcuucudTsdT	sense

1535-1554	8955	AGAAGCAGGGCCUGCUGGG	8956	AGAAGcAGGGCCUGCUGGGdTsdT	antis

1536-1555	8957	CCAGCAGGCCCUGCUUCUC	8958	ccAGcAGGcccuGcuucucdTsdT	sense

1536-1555	8959	GAGAAGCAGGGCCUGCUGG	8960	GAGAAGcAGGGCCUGCUGGdTsdT	antis

1537-1556	8961	CAGCAGGCCCUGCUUCUCC	8962	cAGcAGGcccuGcuucuccdTsdT	sense

1537-1556	8963	GGAGAAGCAGGGCCUGCUG	8964	GGAGAAGcAGGGCCUGCUGdTsdT	antis

1887-1906	8965	GACGGGGUUUGGGGGUGUG	8966	GAcGGGGuuuGGGGGuGuGdTsdT	sense

1887-1906	8967	CACACCCCCAAACCCCGUC	8968	cAcACCCCcAAACCCCGUCdTsdT	antis

1925-1944	8969	GUCCCCUCCCCUCCCCCAG	8970	GuccccuccccucccccAGdTsdT	sense

1925-1944	8971	CUGGGGGAGGGGAGGGGAC	8972	CUGGGGGAGGGGAGGGGACdTsdT	antis

1926-1945	8973	UCCCCUCCCCUCCCCCAGG	8974	uccccuccccucccccAGGdTsdT	sense

1926-1945	8975	CCUGGGGGAGGGGAGGGGA	8976	CCUGGGGGAGGGGAGGGGAdTsdT	antis

2055-2074	8977	AUUUUUUCUUAAAGAAAAC	8978	AuuuuuucuuAAAGAAAAcdTsdT	sense

2055-2074	8979	GUUUUCUUUAAGAAAAAAU	8980	GUUUUCUUuAAGAAAAAAUdTsdT	antis

2143-2162	8981	UCCCUCUCCCCAUCCUGGA	8982	ucccucuccccAuccuGGAdTsdT	sense

2143-2162	8983	UCCAGGAUGGGGAGAGGGA	8984	UCcAGGAUGGGGAGAGGGAdTsdT	antis

TABLE 2

Sequences of duplexes targeting Mouse GSK3-beta
Sequences of duplexes targeting mouse GSK3-beta. Target sequence
location identifies target sequence in mouse GSK3-beta mRNA
NM_019827.6. Sense strand is identical to target sequence.
Antisense strand is complementary to target sequence.

Target	SEQ		SEQ
sequence	ID	Unmodified sequence	ID	Modified sequence
location	NO:	5′ to 3′	NO:	5′ to 3′	Strand

1842-1861	8985	ACUGUAACAUAGUCCGACU	10985	AcuGuAAcAuAGuccGAcudTsdT	sense

1842-1861	8986	AGUCGGACUAUGUUACAGU	10986	AGUCGGACuAUGUuAcAGUdTsdT	antis

1843-1862	8987	CUGUAACAUAGUCCGACUG	10987	cuGuAAcAuAGuccGAcuGdTsdT	sense

1843-1862	8988	CAGUCGGACUAUGUUACAG	10988	cAGUCGGACuAUGUuAcAGdTsdT	antis

1952-1971	8989	GCCAGACACUAUAGUCGAG	10989	GccAGAcAcuAuAGucGAGdTsdT	sense

1952-1971	8990	CUCGACUAUAGUGUCUGGC	10990	CUCGACuAuAGUGUCUGGCdTsdT	antis

1847-1866	8991	AACAUAGUCCGACUGCGGU	10991	AAcAuAGuccGAcuGcGGudTsdT	sense

1847-1866	8992	ACCGCAGUCGGACUAUGUU	10992	ACCGcAGUCGGACuAUGUUdTsdT	antis

1838-1857	8993	GACCACUGUAACAUAGUCC	10993	GAccAcuGuAAcAuAGuccdTsdT	sense

1838-1857	8994	GGACUAUGUUACAGUGGUC	10994	GGACuAUGUuAcAGUGGUCdTsdT	antis

1846-1865	8995	UAACAUAGUCCGACUGCGG	10995	uAAcAuAGuccGAcuGcGGdTsdT	sense

1846-1865	8996	CCGCAGUCGGACUAUGUUA	10996	CCGcAGUCGGACuAUGUuAdTsdT	antis

1849-1868	8997	CAUAGUCCGACUGCGGUAU	10997	cAuAGuccGAcuGcGGuAudTsdT	sense

1849-1868	8998	AUACCGCAGUCGGACUAUG	10998	AuACCGcAGUCGGACuAUGdTsdT	antis

1955-1974	8999	AGACACUAUAGUCGAGCCA	10999	AGAcAcuAuAGucGAGccAdTsdT	sense

1955-1974	9000	UGGCUCGACUAUAGUGUCU	11000	UGGCUCGACuAuAGUGUCUdTsdT	antis

1957-1976	9001	ACACUAUAGUCGAGCCAAG	11001	AcAcuAuAGucGAGccAAGdTsdT	sense

1957-1976	9002	CUUGGCUCGACUAUAGUGU	11002	CUUGGCUCGACuAuAGUGUdTsdT	antis

2169-2188	9003	CAUAUAUCUGUUCUCGGUA	11003	cAuAuAucuGuucucGGuAdTsdT	sense

2169-2188	9004	UACCGAGAACAGAUAUAUG	11004	uACCGAGAAcAGAuAuAUGdTsdT	antis

1788-1807	9005	UACAGGACAAGCGAUUUAA	11005	uAcAGGAcAAGcGAuuuAAdTsdT	sense

1788-1807	9006	UUAAAUCGCUUGUCCUGUA	11006	UuAAAUCGCUUGUCCUGuAdTsdT	antis

1862-1881	9007	CGGUAUUUCUUCUACUCGA	11007	cGGuAuuucuucuAcucGAdTsdT	sense

1862-1881	9008	UCGAGUAGAAGAAAUACCG	11008	UCGAGuAGAAGAAAuACCGdTsdT	antis

2021-2040	9009	UUCAGAAGUCUAGCCUAUA	11009	uucAGAAGucuAGccuAuAdTsdT	sense

2021-2040	9010	UAUAGGCUAGACUUCUGAA	11010	uAuAGGCuAGACUUCUGAAdTsdT	antis

1863-1882	9011	GGUAUUUCUUCUACUCGAG	11011	GGuAuuucuucuAcucGAGdTsdT	sense

1863-1882	9012	CUCGAGUAGAAGAAAUACC	11012	CUCGAGuAGAAGAAAuACCdTsdT	antis

2496-2515	9013	CACCUACCGCCCGGCUAAC	11013	cAccuAccGcccGGcuAAcdTsdT	sense

2496-2515	9014	GUUAGCCGGGCGGUAGGUG	11014	GUuAGCCGGGCGGuAGGUGdTsdT	antis

1796-1815	9015	AAGCGAUUUAAGAACCGAG	11015	AAGcGAuuuAAGAAccGAGdTsdT	sense

1796-1815	9016	CUCGGUUCUUAAAUCGCUU	11016	CUCGGUUCUuAAAUCGCUUdTsdT	antis

1844-1863	9017	UGUAACAUAGUCCGACUGC	11017	uGuAAcAuAGuccGAcuGcdTsdT	sense

1844-1863	9018	GCAGUCGGACUAUGUUACA	11018	GcAGUCGGACuAUGUuAcAdTsdT	antis

2221-2240	9019	UGAUUACACGUCCAGUAUA	11019	uGAuuAcAcGuccAGuAuAdTsdT	sense

2221-2240	9020	UAUACUGGACGUGUAAUCA	11020	uAuACUGGACGUGuAAUcAdTsdT	antis

2228-2247	9021	ACGUCCAGUAUAGAUGUAU	11021	AcGuccAGuAuAGAuGuAudTsdT	sense

2228-2247	9022	AUACAUCUAUACUGGACGU	11022	AuAcAUCuAuACUGGACGUdTsdT	antis

1697-1716	9023	GACACGAAAGUGAUUGGAA	11023	GAcAcGAAAGuGAuuGGAAdTsdT	sense

1697-1716	9024	UUCCAAUCACUUUCGUGUC	11024	UUCcAAUcACUUUCGUGUCdTsdT	antis

1845-1864	9025	GUAACAUAGUCCGACUGCG	11025	GuAAcAuAGuccGAcuGcGdTsdT	sense

1845-1864	9026	CGCAGUCGGACUAUGUUAC	11026	CGcAGUCGGACuAUGUuACdTsdT	antis

1851-1870	9027	UAGUCCGACUGCGGUAUUU	11027	uAGuccGAcuGcGGuAuuudTsdT	sense

1851-1870	9028	AAAUACCGCAGUCGGACUA	11028	AAAuACCGcAGUCGGACuAdTsdT	antis

1871-1890	9029	UUCUACUCGAGUGGUGAGA	11029	uucuAcucGAGuGGuGAGAdTsdT	sense

1871-1890	9030	UCUCACCACUCGAGUAGAA	11030	UCUcACcACUCGAGuAGAAdTsdT	antis

2022-2041	9031	UCAGAAGUCUAGCCUAUAU	11031	ucAGAAGucuAGccuAuAudTsdT	sense

2022-2041	9032	AUAUAGGCUAGACUUCUGA	11032	AuAuAGGCuAGACUUCUGAdTsdT	antis

2024-2043	9033	AGAAGUCUAGCCUAUAUCC	11033	AGAAGucuAGccuAuAuccdTsdT	sense

2024-2043	9034	GGAUAUAGGCUAGACUUCU	11034	GGAuAuAGGCuAGACUUCUdTsdT	antis

2220-2239	9035	CUGAUUACACGUCCAGUAU	11035	cuGAuuAcAcGuccAGuAudTsdT	sense

2220-2239	9036	AUACUGGACGUGUAAUCAG	11036	AuACUGGACGUGuAAUcAGdTsdT	antis

1789-1808	9037	ACAGGACAAGCGAUUUAAG	11037	AcAGGAcAAGcGAuuuAAGdTsdT	sense

1789-1808	9038	CUUAAAUCGCUUGUCCUGU	11038	CUuAAAUCGCUUGUCCUGUdTsdT	antis

1922-1941	9039	GACUAUGUUCCGGAGACAG	11039	GAcuAuGuuccGGAGAcAGdTsdT	sense

1922-1941	9040	CUGUCUCCGGAACAUAGUC	11040	CUGUCUCCGGAAcAuAGUCdTsdT	antis

2020-2039	9041	GUUCAGAAGUCUAGCCUAU	11041	GuucAGAAGucuAGccuAudTsdT	sense

2020-2039	9042	AUAGGCUAGACUUCUGAAC	11042	AuAGGCuAGACUUCUGAACdTsdT	antis

2492-2511	9043	UACACACCUACCGCCCGGC	11043	uAcAcAccuAccGcccGGcdTsdT	sense

2492-2511	9044	GCCGGGCGGUAGGUGUGUA	11044	GCCGGGCGGuAGGUGUGuAdTsdT	antis

1678-1697	9045	ACAGGAAGUCAGUUAUACA	11045	AcAGGAAGucAGuuAuAcAdTsdT	sense

1678-1697	9046	UGUAUAACUGACUUCCUGU	11046	UGuAuAACUGACUUCCUGUdTsdT	antis

1840-1859	9047	CCACUGUAACAUAGUCCGA	11047	ccAcuGuAAcAuAGuccGAdTsdT	sense

1840-1859	9048	UCGGACUAUGUUACAGUGG	11048	UCGGACuAUGUuAcAGUGGdTsdT	antis

2487-2506	9049	UGGAGUACACACCUACCGC	11049	uGGAGuAcAcAccuAccGcdTsdT	sense

2487-2506	9050	GCGGUAGGUGUGUACUCCA	11050	GCGGuAGGUGUGuACUCcAdTsdT	antis

1924-1943	9051	CUAUGUUCCGGAGACAGUG	11051	cuAuGuuccGGAGAcAGuGdTsdT	sense

1924-1943	9052	CACUGUCUCCGGAACAUAG	11052	cACUGUCUCCGGAAcAuAGdTsdT	antis

2176-2195	9053	CUGUUCUCGGUACUACAGG	11053	cuGuucucGGuAcuAcAGGdTsdT	sense

2176-2195	9054	CCUGUAGUACCGAGAACAG	11054	CCUGuAGuACCGAGAAcAGdTsdT	antis

2177-2196	9055	UGUUCUCGGUACUACAGGG	11055	uGuucucGGuAcuAcAGGGdTsdT	sense

2177-2196	9056	CCCUGUAGUACCGAGAACA	11056	CCCUGuAGuACCGAGAAcAdTsdT	antis

2502-2521	9057	CCGCCCGGCUAACACCACU	11057	ccGcccGGcuAAcAccAcudTsdT	sense

2502-2521	9058	AGUGGUGUUAGCCGGGCGG	11058	AGUGGUGUuAGCCGGGCGGdTsdT	antis

2499-2518	9059	CUACCGCCCGGCUAACACC	11059	cuAccGcccGGcuAAcAccdTsdT	sense

2499-2518	9060	GGUGUUAGCCGGGCGGUAG	11060	GGUGUuAGCCGGGCGGuAGdTsdT	antis

2223-2242	9061	AUUACACGUCCAGUAUAGA	11061	AuuAcAcGuccAGuAuAGAdTsdT	sense

2223-2242	9062	UCUAUACUGGACGUGUAAU	11062	UCuAuACUGGACGUGuAAUdTsdT	antis

1873-1892	9063	CUACUCGAGUGGUGAGAAG	11063	cuAcucGAGuGGuGAGAAGdTsdT	sense

1873-1892	9064	CUUCUCACCACUCGAGUAG	11064	CUUCUcACcACUCGAGuAGdTsdT	antis

1918-1937	9065	GCUGGACUAUGUUCCGGAG	11065	GcuGGAcuAuGuuccGGAGdTsdT	sense

1918-1937	9066	CUCCGGAACAUAGUCCAGC	11066	CUCCGGAAcAuAGUCcAGCdTsdT	antis

1919-1938	9067	CUGGACUAUGUUCCGGAGA	11067	cuGGAcuAuGuuccGGAGAdTsdT	sense

1919-1938	9068	UCUCCGGAACAUAGUCCAG	11068	UCUCCGGAAcAuAGUCcAGdTsdT	antis

1950-1969	9069	UCGCCAGACACUAUAGUCG	11069	ucGccAGAcAcuAuAGucGdTsdT	sense

1950-1969	9070	CGACUAUAGUGUCUGGCGA	11070	CGACuAuAGUGUCUGGCGAdTsdT	antis

1958-1977	9071	CACUAUAGUCGAGCCAAGC	11071	cAcuAuAGucGAGccAAGcdTsdT	sense

1958-1977	9072	GCUUGGCUCGACUAUAGUG	11072	GCUUGGCUCGACuAuAGUGdTsdT	antis

2222-2241	9073	GAUUACACGUCCAGUAUAG	11073	GAuuAcAcGuccAGuAuAGdTsdT	sense

2222-2241	9074	CUAUACUGGACGUGUAAUC	11074	CuAuACUGGACGUGuAAUCdTsdT	antis

2224-2243	9075	UUACACGUCCAGUAUAGAU	11075	uuAcAcGuccAGuAuAGAudTsdT	sense

2224-2243	9076	AUCUAUACUGGACGUGUAA	11076	AUCuAuACUGGACGUGuAAdTsdT	antis

2440-2459	9077	CCGGCCCCGAACUCCACCA	11077	ccGGccccGAAcuccAccAdTsdT	sense

2440-2459	9078	UGGUGGAGUUCGGGGCCGG	11078	UGGUGGAGUUCGGGGCCGGdTsdT	antis

2493-2512	9079	ACACACCUACCGCCCGGCU	11079	AcAcAccuAccGcccGGcudTsdT	sense

2493-2512	9080	AGCCGGGCGGUAGGUGUGU	11080	AGCCGGGCGGuAGGUGUGUdTsdT	antis

2494-2513	9081	CACACCUACCGCCCGGCUA	11081	cAcAccuAccGcccGGcuAdTsdT	sense

2494-2513	9082	UAGCCGGGCGGUAGGUGUG	11082	uAGCCGGGCGGuAGGUGUGdTsdT	antis

2497-2516	9083	ACCUACCGCCCGGCUAACA	11083	AccuAccGcccGGcuAAcAdTsdT	sense

2497-2516	9084	UGUUAGCCGGGCGGUAGGU	11084	UGUuAGCCGGGCGGuAGGUdTsdT	antis

2498-2517	9085	CCUACCGCCCGGCUAACAC	11085	ccuAccGcccGGcuAAcAcdTsdT	sense

2498-2517	9086	GUGUUAGCCGGGCGGUAGG	11086	GUGUuAGCCGGGCGGuAGGdTsdT	antis

1525-1544	9087	CAUGUCGGGGCGACCGAGA	11087	cAuGucGGGGcGAccGAGAdTsdT	sense

1525-1544	9088	UCUCGGUCGCCCCGACAUG	11088	UCUCGGUCGCCCCGAcAUGdTsdT	antis

1528-1547	9089	GUCGGGGCGACCGAGAACC	11089	GucGGGGcGAccGAGAAccdTsdT	sense

1528-1547	9090	GGUUCUCGGUCGCCCCGAC	11090	GGUUCUCGGUCGCCCCGACdTsdT	antis

1533-1552	9091	GGCGACCGAGAACCACCUC	11091	GGcGAccGAGAAccAccucdTsdT	sense

1533-1552	9092	GAGGUGGUUCUCGGUCGCC	11092	GAGGUGGUUCUCGGUCGCCdTsdT	antis

1793-1812	9093	GACAAGCGAUUUAAGAACC	11093	GAcAAGcGAuuuAAGAAccdTsdT	sense

1793-1812	9094	GGUUCUUAAAUCGCUUGUC	11094	GGUUCUuAAAUCGCUUGUCdTsdT	antis

1797-1816	9095	AGCGAUUUAAGAACCGAGA	11095	AGcGAuuuAAGAAccGAGAdTsdT	sense

1797-1816	9096	UCUCGGUUCUUAAAUCGCU	11096	UCUCGGUUCUuAAAUCGCUdTsdT	antis

1798-1817	9097	GCGAUUUAAGAACCGAGAG	11097	GcGAuuuAAGAAccGAGAGdTsdT	sense

1798-1817	9098	CUCUCGGUUCUUAAAUCGC	11098	CUCUCGGUUCUuAAAUCGCdTsdT	antis

1799-1818	9099	CGAUUUAAGAACCGAGAGC	11099	cGAuuuAAGAAccGAGAGcdTsdT	sense

1799-1818	9100	GCUCUCGGUUCUUAAAUCG	11100	GCUCUCGGUUCUuAAAUCGdTsdT	antis

1832-1851	9101	AAGCUAGACCACUGUAACA	11101	AAGcuAGAccAcuGuAAcAdTsdT	sense

1832-1851	9102	UGUUACAGUGGUCUAGCUU	11102	UGUuAcAGUGGUCuAGCUUdTsdT	antis

1836-1855	9103	UAGACCACUGUAACAUAGU	11103	uAGAccAcuGuAAcAuAGudTsdT	sense

1836-1855	9104	ACUAUGUUACAGUGGUCUA	11104	ACuAUGUuAcAGUGGUCuAdTsdT	antis

1850-1869	9105	AUAGUCCGACUGCGGUAUU	11105	AuAGuccGAcuGcGGuAuudTsdT	sense

1850-1869	9106	AAUACCGCAGUCGGACUAU	11106	AAuACCGcAGUCGGACuAUdTsdT	antis

1852-1871	9107	AGUCCGACUGCGGUAUUUC	11107	AGuccGAcuGcGGuAuuucdTsdT	sense

1852-1871	9108	GAAAUACCGCAGUCGGACU	11108	GAAAuACCGcAGUCGGACUdTsdT	antis

1853-1872	9109	GUCCGACUGCGGUAUUUCU	11109	GuccGAcuGcGGuAuuucudTsdT	sense

1853-1872	9110	AGAAAUACCGCAGUCGGAC	11110	AGAAAuACCGcAGUCGGACdTsdT	antis

1855-1874	9111	CCGACUGCGGUAUUUCUUC	11111	ccGAcuGcGGuAuuucuucdTsdT	sense

1855-1874	9112	GAAGAAAUACCGCAGUCGG	11112	GAAGAAAuACCGcAGUCGGdTsdT	antis

1870-1889	9113	CUUCUACUCGAGUGGUGAG	11113	cuucuAcucGAGuGGuGAGdTsdT	sense

1870-1889	9114	CUCACCACUCGAGUAGAAG	11114	CUcACcACUCGAGuAGAAGdTsdT	antis

1895-1914	9115	GAUGAGGUCUACCUUAACC	11115	GAuGAGGucuAccuuAAccdTsdT	sense

1895-1914	9116	GGUUAAGGUAGACCUCAUC	11116	GGUuAAGGuAGACCUcAUCdTsdT	antis

1916-1935	9117	GUGCUGGACUAUGUUCCGG	11117	GuGcuGGAcuAuGuuccGGdTsdT	sense

1916-1935	9118	CCGGAACAUAGUCCAGCAC	11118	CCGGAAcAuAGUCcAGcACdTsdT	antis

1927-1946	9119	UGUUCCGGAGACAGUGUAC	11119	uGuuccGGAGAcAGuGuAcdTsdT	sense

1927-1946	9120	GUACACUGUCUCCGGAACA	11120	GuAcACUGUCUCCGGAAcAdTsdT	antis

1953-1972	9121	CCAGACACUAUAGUCGAGC	11121	ccAGAcAcuAuAGucGAGcdTsdT	sense

1953-1972	9122	GCUCGACUAUAGUGUCUGG	11122	GCUCGACuAuAGUGUCUGGdTsdT	antis

1959-1978	9123	ACUAUAGUCGAGCCAAGCA	11123	AcuAuAGucGAGccAAGcAdTsdT	sense

1959-1978	9124	UGCUUGGCUCGACUAUAGU	11124	UGCUUGGCUCGACuAuAGUdTsdT	antis

1960-1979	9125	CUAUAGUCGAGCCAAGCAG	11125	cuAuAGucGAGccAAGcAGdTsdT	sense

1960-1979	9126	CUGCUUGGCUCGACUAUAG	11126	CUGCUUGGCUCGACuAuAGdTsdT	antis

2023-2042	9127	CAGAAGUCUAGCCUAUAUC	11127	cAGAAGucuAGccuAuAucdTsdT	sense

2023-2042	9128	GAUAUAGGCUAGACUUCUG	11128	GAuAuAGGCuAGACUUCUGdTsdT	antis

2089-2108	9129	GUUGGAUCCUGAUACAGCU	11129	GuuGGAuccuGAuAcAGcudTsdT	sense

2089-2108	9130	AGCUGUAUCAGGAUCCAAC	11130	AGCUGuAUcAGGAUCcAACdTsdT	antis

2179-2198	9131	UUCUCGGUACUACAGGGCA	11131	uucucGGuAcuAcAGGGcAdTsdT	sense

2179-2198	9132	UGCCCUGUAGUACCGAGAA	11132	UGCCCUGuAGuACCGAGAAdTsdT	antis

2188-2207	9133	CUACAGGGCACCAGAGUUG	11133	cuAcAGGGcAccAGAGuuGdTsdT	sense

2188-2207	9134	CAACUCUGGUGCCCUGUAG	11134	cAACUCUGGUGCCCUGuAGdTsdT	antis

2218-2237	9135	CACUGAUUACACGUCCAGU	11135	cAcuGAuuAcAcGuccAGudTsdT	sense

2218-2237	9136	ACUGGACGUGUAAUCAGUG	11136	ACUGGACGUGuAAUcAGUGdTsdT	antis

2219-2238	9137	ACUGAUUACACGUCCAGUA	11137	AcuGAuuAcAcGuccAGuAdTsdT	sense

2219-2238	9138	UACUGGACGUGUAAUCAGU	11138	uACUGGACGUGuAAUcAGUdTsdT	antis

2226-2245	9139	ACACGUCCAGUAUAGAUGU	11139	AcAcGuccAGuAuAGAuGudTsdT	sense

2226-2245	9140	ACAUCUAUACUGGACGUGU	11140	AcAUCuAuACUGGACGUGUdTsdT	antis

2227-2246	9141	CACGUCCAGUAUAGAUGUA	11141	cAcGuccAGuAuAGAuGuAdTsdT	sense

2227-2246	9142	UACAUCUAUACUGGACGUG	11142	uAcAUCuAuACUGGACGUGdTsdT	antis

2276-2295	9143	UUGCUAGGACAACCAAUAU	11143	uuGcuAGGAcAAccAAuAudTsdT	sense

2276-2295	9144	AUAUUGGUUGUCCUAGCAA	11144	AuAUUGGUUGUCCuAGcAAdTsdT	antis

2277-2296	9145	UGCUAGGACAACCAAUAUU	11145	uGcuAGGAcAAccAAuAuudTsdT	sense

2277-2296	9146	AAUAUUGGUUGUCCUAGCA	11146	AAuAUUGGUUGUCCuAGcAdTsdT	antis

2279-2298	9147	CUAGGACAACCAAUAUUUC	11147	cuAGGAcAAccAAuAuuucdTsdT	sense

2279-2298	9148	GAAAUAUUGGUUGUCCUAG	11148	GAAAuAUUGGUUGUCCuAGdTsdT	antis

2306-2325	9149	AGUGGUGUGGAUCAGUUGG	11149	AGuGGuGuGGAucAGuuGGdTsdT	sense

2306-2325	9150	CCAACUGAUCCACACCACU	11150	CcAACUGAUCcAcACcACUdTsdT	antis

2488-2507	9151	GGAGUACACACCUACCGCC	11151	GGAGuAcAcAccuAccGccdTsdT	sense

2488-2507	9152	GGCGGUAGGUGUGUACUCC	11152	GGCGGuAGGUGUGuACUCCdTsdT	antis

2491-2510	9153	GUACACACCUACCGCCCGG	11153	GuAcAcAccuAccGcccGGdTsdT	sense

2491-2510	9154	CCGGGCGGUAGGUGUGUAC	11154	CCGGGCGGuAGGUGUGuACdTsdT	antis

2501-2520	9155	ACCGCCCGGCUAACACCAC	11155	AccGcccGGcuAAcAccAcdTsdT	sense

2501-2520	9156	GUGGUGUUAGCCGGGCGGU	11156	GUGGUGUuAGCCGGGCGGUdTsdT	antis

2506-2525	9157	CCGGCUAACACCACUGGAA	11157	ccGGcuAAcAccAcuGGAAdTsdT	sense

2506-2525	9158	UUCCAGUGGUGUUAGCCGG	11158	UUCcAGUGGUGUuAGCCGGdTsdT	antis

1695-1714	9159	CAGACACGAAAGUGAUUGG	11159	cAGAcAcGAAAGuGAuuGGdTsdT	sense

1695-1714	9160	CCAAUCACUUUCGUGUCUG	11160	CcAAUcACUUUCGUGUCUGdTsdT	antis

1720-1739	9161	AUCAUUUGGUGUGGUAUAU	11161	AucAuuuGGuGuGGuAuAudTsdT	sense

1720-1739	9162	AUAUACCACACCAAAUGAU	11162	AuAuACcAcACcAAAUGAUdTsdT	antis

1722-1741	9163	CAUUUGGUGUGGUAUAUCA	11163	cAuuuGGuGuGGuAuAucAdTsdT	sense

1722-1741	9164	UGAUAUACCACACCAAAUG	11164	UGAuAuACcAcACcAAAUGdTsdT	antis

1833-1852	9165	AGCUAGACCACUGUAACAU	11165	AGcuAGAccAcuGuAAcAudTsdT	sense

1833-1852	9166	AUGUUACAGUGGUCUAGCU	11166	AUGUuAcAGUGGUCuAGCUdTsdT	antis

1848-1867	9167	ACAUAGUCCGACUGCGGUA	11167	AcAuAGuccGAcuGcGGuAdTsdT	sense

1848-1867	9168	UACCGCAGUCGGACUAUGU	11168	uACCGcAGUCGGACuAUGUdTsdT	antis

1872-1891	9169	UCUACUCGAGUGGUGAGAA	11169	ucuAcucGAGuGGuGAGAAdTsdT	sense

1872-1891	9170	UUCUCACCACUCGAGUAGA	11170	UUCUcACcACUCGAGuAGAdTsdT	antis

1998-2017	9171	UCAAGUUGUAUAUGUAUCA	11171	ucAAGuuGuAuAuGuAucAdTsdT	sense

1998-2017	9172	UGAUACAUAUACAACUUGA	11172	UGAuAcAuAuAcAACUUGAdTsdT	antis

2011-2030	9173	GUAUCAGCUGUUCAGAAGU	11173	GuAucAGcuGuucAGAAGudTsdT	sense

2011-2030	9174	ACUUCUGAACAGCUGAUAC	11174	ACUUCUGAAcAGCUGAuACdTsdT	antis

2054-2073	9175	AUCUGCCAUCGAGACAUUA	11175	AucuGccAucGAGAcAuuAdTsdT	sense

2054-2073	9176	UAAUGUCUCGAUGGCAGAU	11176	uAAUGUCUCGAUGGcAGAUdTsdT	antis

2153-2172	9177	GGAGAGCCCAAUGUUUCAU	11177	GGAGAGcccAAuGuuucAudTsdT	sense

2153-2172	9178	AUGAAACAUUGGGCUCUCC	11178	AUGAAAcAUUGGGCUCUCCdTsdT	antis

2168-2187	9179	UCAUAUAUCUGUUCUCGGU	11179	ucAuAuAucuGuucucGGudTsdT	sense

2168-2187	9180	ACCGAGAACAGAUAUAUGA	11180	ACCGAGAAcAGAuAuAUGAdTsdT	antis

2181-2200	9181	CUCGGUACUACAGGGCACC	11181	cucGGuAcuAcAGGGcAccdTsdT	sense

2181-2200	9182	GGUGCCCUGUAGUACCGAG	11182	GGUGCCCUGuAGuACCGAGdTsdT	antis

2305-2324	9183	CAGUGGUGUGGAUCAGUUG	11183	cAGuGGuGuGGAucAGuuGdTsdT	sense

2305-2324	9184	CAACUGAUCCACACCACUG	11184	cAACUGAUCcAcACcACUGdTsdT	antis

2354-2373	9185	ACAAGGGAGCAAAUUAGAG	11185	AcAAGGGAGcAAAuuAGAGdTsdT	sense

2354-2373	9186	CUCUAAUUUGCUCCCUUGU	11186	CUCuAAUUUGCUCCCUUGUdTsdT	antis

2427-2446	9187	GGACAAAGGUCUUCCGGCC	11187	GGAcAAAGGucuuccGGccdTsdT	sense

2427-2446	9188	GGCCGGAAGACCUUUGUCC	11188	GGCCGGAAGACCUUUGUCCdTsdT	antis

1529-1548	9189	UCGGGGCGACCGAGAACCA	11189	ucGGGGcGAccGAGAAccAdTsdT	sense

1529-1548	9190	UGGUUCUCGGUCGCCCCGA	11190	UGGUUCUCGGUCGCCCCGAdTsdT	antis

1532-1551	9191	GGGCGACCGAGAACCACCU	11191	GGGcGAccGAGAAccAccudTsdT	sense

1532-1551	9192	AGGUGGUUCUCGGUCGCCC	11192	AGGUGGUUCUCGGUCGCCCdTsdT	antis

1541-1560	9193	AGAACCACCUCCUUUGCGG	11193	AGAAccAccuccuuuGcGGdTsdT	sense

1541-1560	9194	CCGCAAAGGAGGUGGUUCU	11194	CCGcAAAGGAGGUGGUUCUdTsdT	antis

1591-1610	9195	UUUUGGUAGCAUGAAAGUU	11195	uuuuGGuAGcAuGAAAGuudTsdT	sense

1591-1610	9196	AACUUUCAUGCUACCAAAA	11196	AACUUUcAUGCuACcAAAAdTsdT	antis

1677-1696	9197	CACAGGAAGUCAGUUAUAC	11197	cAcAGGAAGucAGuuAuAcdTsdT	sense

1677-1696	9198	GUAUAACUGACUUCCUGUG	11198	GuAuAACUGACUUCCUGUGdTsdT	antis

1679-1698	9199	CAGGAAGUCAGUUAUACAG	11199	cAGGAAGucAGuuAuAcAGdTsdT	sense

1679-1698	9200	CUGUAUAACUGACUUCCUG	11200	CUGuAuAACUGACUUCCUGdTsdT	antis

1680-1699	9201	AGGAAGUCAGUUAUACAGA	11201	AGGAAGucAGuuAuAcAGAdTsdT	sense

1680-1699	9202	UCUGUAUAACUGACUUCCU	11202	UCUGuAuAACUGACUUCCUdTsdT	antis

1681-1700	9203	GGAAGUCAGUUAUACAGAC	11203	GGAAGucAGuuAuAcAGAcdTsdT	sense

1681-1700	9204	GUCUGUAUAACUGACUUCC	11204	GUCUGuAuAACUGACUUCCdTsdT	antis

1705-1724	9205	AGUGAUUGGAAAUGGAUCA	11205	AGuGAuuGGAAAuGGAucAdTsdT	sense

1705-1724	9206	UGAUCCAUUUCCAAUCACU	11206	UGAUCcAUUUCcAAUcACUdTsdT	antis

1706-1725	9207	GUGAUUGGAAAUGGAUCAU	11207	GuGAuuGGAAAuGGAucAudTsdT	sense

1706-1725	9208	AUGAUCCAUUUCCAAUCAC	11208	AUGAUCcAUUUCcAAUcACdTsdT	antis

1708-1727	9209	GAUUGGAAAUGGAUCAUUU	11209	GAuuGGAAAuGGAucAuuudTsdT	sense

1708-1727	9210	AAAUGAUCCAUUUCCAAUC	11210	AAAUGAUCcAUUUCcAAUCdTsdT	antis

1724-1743	9211	UUUGGUGUGGUAUAUCAAG	11211	uuuGGuGuGGuAuAucAAGdTsdT	sense

1724-1743	9212	CUUGAUAUACCACACCAAA	11212	CUUGAuAuACcAcACcAAAdTsdT	antis

1725-1744	9213	UUGGUGUGGUAUAUCAAGC	11213	uuGGuGuGGuAuAucAAGcdTsdT	sense

1725-1744	9214	GCUUGAUAUACCACACCAA	11214	GCUUGAuAuACcAcACcAAdTsdT	antis

1727-1746	9215	GGUGUGGUAUAUCAAGCCA	11215	GGuGuGGuAuAucAAGccAdTsdT	sense

1727-1746	9216	UGGCUUGAUAUACCACACC	11216	UGGCUUGAuAuACcAcACCdTsdT	antis

1739-1758	9217	CAAGCCAAACUUUGUGAUU	11217	cAAGccAAAcuuuGuGAuudTsdT	sense

1739-1758	9218	AAUCACAAAGUUUGGCUUG	11218	AAUcAcAAAGUUUGGCUUGdTsdT	antis

1785-1804	9219	UUCUACAGGACAAGCGAUU	11219	uucuAcAGGAcAAGcGAuudTsdT	sense

1785-1804	9220	AAUCGCUUGUCCUGUAGAA	11220	AAUCGCUUGUCCUGuAGAAdTsdT	antis

1828-1847	9221	GAGAAAGCUAGACCACUGU	11221	GAGAAAGcuAGAccAcuGudTsdT	sense

1828-1847	9222	ACAGUGGUCUAGCUUUCUC	11222	AcAGUGGUCuAGCUUUCUCdTsdT	antis

1829-1848	9223	AGAAAGCUAGACCACUGUA	11223	AGAAAGcuAGAccAcuGuAdTsdT	sense

1829-1848	9224	UACAGUGGUCUAGCUUUCU	11224	uAcAGUGGUCuAGCUUUCUdTsdT	antis

1837-1856	9225	AGACCACUGUAACAUAGUC	11225	AGAccAcuGuAAcAuAGucdTsdT	sense

1837-1856	9226	GACUAUGUUACAGUGGUCU	11226	GACuAUGUuAcAGUGGUCUdTsdT	antis

1839-1858	9227	ACCACUGUAACAUAGUCCG	11227	AccAcuGuAAcAuAGuccGdTsdT	sense

1839-1858	9228	CGGACUAUGUUACAGUGGU	11228	CGGACuAUGUuAcAGUGGUdTsdT	antis

1841-1860	9229	CACUGUAACAUAGUCCGAC	11229	cAcuGuAAcAuAGuccGAcdTsdT	sense

1841-1860	9230	GUCGGACUAUGUUACAGUG	11230	GUCGGACuAUGUuAcAGUGdTsdT	antis

1864-1883	9231	GUAUUUCUUCUACUCGAGU	11231	GuAuuucuucuAcucGAGudTsdT	sense

1864-1883	9232	ACUCGAGUAGAAGAAAUAC	11232	ACUCGAGuAGAAGAAAuACdTsdT	antis

1865-1884	9233	UAUUUCUUCUACUCGAGUG	11233	uAuuucuucuAcucGAGuGdTsdT	sense

1865-1884	9234	CACUCGAGUAGAAGAAAUA	11234	cACUCGAGuAGAAGAAAuAdTsdT	antis

1867-1886	9235	UUUCUUCUACUCGAGUGGU	11235	uuucuucuAcucGAGuGGudTsdT	sense

1867-1886	9236	ACCACUCGAGUAGAAGAAA	11236	ACcACUCGAGuAGAAGAAAdTsdT	antis

1874-1893	9237	UACUCGAGUGGUGAGAAGA	11237	uAcucGAGuGGuGAGAAGAdTsdT	sense

1874-1893	9238	UCUUCUCACCACUCGAGUA	11238	UCUUCUcACcACUCGAGuAdTsdT	antis

1894-1913	9239	AGAUGAGGUCUACCUUAAC	11239	AGAuGAGGucuAccuuAAcdTsdT	sense

1894-1913	9240	GUUAAGGUAGACCUCAUCU	11240	GUuAAGGuAGACCUcAUCUdTsdT	antis

1921-1940	9241	GGACUAUGUUCCGGAGACA	11241	GGAcuAuGuuccGGAGAcAdTsdT	sense

1921-1940	9242	UGUCUCCGGAACAUAGUCC	11242	UGUCUCCGGAAcAuAGUCCdTsdT	antis

1954-1973	9243	CAGACACUAUAGUCGAGCC	11243	cAGAcAcuAuAGucGAGccdTsdT	sense

1954-1973	9244	GGCUCGACUAUAGUGUCUG	11244	GGCUCGACuAuAGUGUCUGdTsdT	antis

2006-2025	9245	UAUAUGUAUCAGCUGUUCA	11245	uAuAuGuAucAGcuGuucAdTsdT	sense

2006-2025	9246	UGAACAGCUGAUACAUAUA	11246	UGAAcAGCUGAuAcAuAuAdTsdT	antis

2017-2036	9247	GCUGUUCAGAAGUCUAGCC	11247	GcuGuucAGAAGucuAGccdTsdT	sense

2017-2036	9248	GGCUAGACUUCUGAACAGC	11248	GGCuAGACUUCUGAAcAGCdTsdT	antis

2019-2038	9249	UGUUCAGAAGUCUAGCCUA	11249	uGuucAGAAGucuAGccuAdTsdT	sense

2019-2038	9250	UAGGCUAGACUUCUGAACA	11250	uAGGCuAGACUUCUGAAcAdTsdT	antis

2026-2045	9251	AAGUCUAGCCUAUAUCCAU	11251	AAGucuAGccuAuAuccAudTsdT	sense

2026-2045	9252	AUGGAUAUAGGCUAGACUU	11252	AUGGAuAuAGGCuAGACUUdTsdT	antis

2052-2071	9253	GAAUCUGCCAUCGAGACAU	11253	GAAucuGccAucGAGAcAudTsdT	sense

2052-2071	9254	AUGUCUCGAUGGCAGAUUC	11254	AUGUCUCGAUGGcAGAUUCdTsdT	antis

2072-2091	9255	AAACCACAGAACCUCUUGU	11255	AAAccAcAGAAccucuuGudTsdT	sense

2072-2091	9256	ACAAGAGGUUCUGUGGUUU	11256	AcAAGAGGUUCUGUGGUUUdTsdT	antis

2082-2101	9257	ACCUCUUGUUGGAUCCUGA	11257	AccucuuGuuGGAuccuGAdTsdT	sense

2082-2101	9258	UCAGGAUCCAACAAGAGGU	11258	UcAGGAUCcAAcAAGAGGUdTsdT	antis

2088-2107	9259	UGUUGGAUCCUGAUACAGC	11259	uGuuGGAuccuGAuAcAGcdTsdT	sense

2088-2107	9260	GCUGUAUCAGGAUCCAACA	11260	GCUGuAUcAGGAUCcAAcAdTsdT	antis

2096-2115	9261	CCUGAUACAGCUGUAUUAA	11261	ccuGAuAcAGcuGuAuuAAdTsdT	sense

2096-2115	9262	UUAAUACAGCUGUAUCAGG	11262	UuAAuAcAGCUGuAUcAGGdTsdT	antis

2167-2186	9263	UUCAUAUAUCUGUUCUCGG	11263	uucAuAuAucuGuucucGGdTsdT	sense

2167-2186	9264	CCGAGAACAGAUAUAUGAA	11264	CCGAGAAcAGAuAuAUGAAdTsdT	antis

2192-2211	9265	AGGGCACCAGAGUUGAUCU	11265	AGGGcAccAGAGuuGAucudTsdT	sense

2192-2211	9266	AGAUCAACUCUGGUGCCCU	11266	AGAUcAACUCUGGUGCCCUdTsdT	antis

2213-2232	9267	GGAGCCACUGAUUACACGU	11267	GGAGccAcuGAuuAcAcGudTsdT	sense

2213-2232	9268	ACGUGUAAUCAGUGGCUCC	11268	ACGUGuAAUcAGUGGCUCCdTsdT	antis

2214-2233	9269	GAGCCACUGAUUACACGUC	11269	GAGccAcuGAuuAcAcGucdTsdT	sense

2214-2233	9270	GACGUGUAAUCAGUGGCUC	11270	GACGUGuAAUcAGUGGCUCdTsdT	antis

2225-2244	9271	UACACGUCCAGUAUAGAUG	11271	uAcAcGuccAGuAuAGAuGdTsdT	sense

2225-2244	9272	CAUCUAUACUGGACGUGUA	11272	cAUCuAuACUGGACGUGuAdTsdT	antis

2229-2248	9273	CGUCCAGUAUAGAUGUAUG	11273	cGuccAGuAuAGAuGuAuGdTsdT	sense

2229-2248	9274	CAUACAUCUAUACUGGACG	11274	cAuAcAUCuAuACUGGACGdTsdT	antis

2230-2249	9275	GUCCAGUAUAGAUGUAUGG	11275	GuccAGuAuAGAuGuAuGGdTsdT	sense

2230-2249	9276	CCAUACAUCUAUACUGGAC	11276	CcAuAcAUCuAuACUGGACdTsdT	antis

2233-2252	9277	CAGUAUAGAUGUAUGGUCU	11277	cAGuAuAGAuGuAuGGucudTsdT	sense

2233-2252	9278	AGACCAUACAUCUAUACUG	11278	AGACcAuAcAUCuAuACUGdTsdT	antis

2236-2255	9279	UAUAGAUGUAUGGUCUGCA	11279	uAuAGAuGuAuGGucuGcAdTsdT	sense

2236-2255	9280	UGCAGACCAUACAUCUAUA	11280	UGcAGACcAuAcAUCuAuAdTsdT	antis

2239-2258	9281	AGAUGUAUGGUCUGCAGGC	11281	AGAuGuAuGGucuGcAGGcdTsdT	sense

2239-2258	9282	GCCUGCAGACCAUACAUCU	11282	GCCUGcAGACcAuAcAUCUdTsdT	antis

2268-2287	9283	CUGAAUUGUUGCUAGGACA	11283	cuGAAuuGuuGcuAGGAcAdTsdT	sense

2268-2287	9284	UGUCCUAGCAACAAUUCAG	11284	UGUCCuAGcAAcAAUUcAGdTsdT	antis

2278-2297	9285	GCUAGGACAACCAAUAUUU	11285	GcuAGGAcAAccAAuAuuudTsdT	sense

2278-2297	9286	AAAUAUUGGUUGUCCUAGC	11286	AAAuAUUGGUUGUCCuAGCdTsdT	antis

2286-2305	9287	AACCAAUAUUUCCUGGGGA	11287	AAccAAuAuuuccuGGGGAdTsdT	sense

2286-2305	9288	UCCCCAGGAAAUAUUGGUU	11288	UCCCcAGGAAAuAUUGGUUdTsdT	antis

2339-2358	9289	GUCCUAGGAACACCAACAA	11289	GuccuAGGAAcAccAAcAAdTsdT	sense

2339-2358	9290	UUGUUGGUGUUCCUAGGAC	11290	UUGUUGGUGUUCCuAGGACdTsdT	antis

2340-2359	9291	UCCUAGGAACACCAACAAG	11291	uccuAGGAAcAccAAcAAGdTsdT	sense

2340-2359	9292	CUUGUUGGUGUUCCUAGGA	11292	CUUGUUGGUGUUCCuAGGAdTsdT	antis

2342-2361	9293	CUAGGAACACCAACAAGGG	11293	cuAGGAAcAccAAcAAGGGdTsdT	sense

2342-2361	9294	CCCUUGUUGGUGUUCCUAG	11294	CCCUUGUUGGUGUUCCuAGdTsdT	antis

2344-2363	9295	AGGAACACCAACAAGGGAG	11295	AGGAAcAccAAcAAGGGAGdTsdT	sense

2344-2363	9296	CUCCCUUGUUGGUGUUCCU	11296	CUCCCUUGUUGGUGUUCCUdTsdT	antis

2355-2374	9297	CAAGGGAGCAAAUUAGAGA	11297	cAAGGGAGcAAAuuAGAGAdTsdT	sense

2355-2374	9298	UCUCUAAUUUGCUCCCUUG	11298	UCUCuAAUUUGCUCCCUUGdTsdT	antis

2397-2416	9299	UCAAAUUCCCUCAAAUCAA	11299	ucAAAuucccucAAAucAAdTsdT	sense

2397-2416	9300	UUGAUUUGAGGGAAUUUGA	11300	UUGAUUUGAGGGAAUUUGAdTsdT	antis

2434-2453	9301	GGUCUUCCGGCCCCGAACU	11301	GGucuuccGGccccGAAcudTsdT	sense

2434-2453	9302	AGUUCGGGGCCGGAAGACC	11302	AGUUCGGGGCCGGAAGACCdTsdT	antis

2435-2454	9303	GUCUUCCGGCCCCGAACUC	11303	GucuuccGGccccGAAcucdTsdT	sense

2435-2454	9304	GAGUUCGGGGCCGGAAGAC	11304	GAGUUCGGGGCCGGAAGACdTsdT	antis

2437-2456	9305	CUUCCGGCCCCGAACUCCA	11305	cuuccGGccccGAAcuccAdTsdT	sense

2437-2456	9306	UGGAGUUCGGGGCCGGAAG	11306	UGGAGUUCGGGGCCGGAAGdTsdT	antis

2453-2472	9307	CCACCAGAGGCAAUUGCAC	11307	ccAccAGAGGcAAuuGcAcdTsdT	sense

2453-2472	9308	GUGCAAUUGCCUCUGGUGG	11308	GUGcAAUUGCCUCUGGUGGdTsdT	antis

2467-2486	9309	UGCACUGUGCAGCCGUCUG	11309	uGcAcuGuGcAGccGucuGdTsdT	sense

2467-2486	9310	CAGACGGCUGCACAGUGCA	11310	cAGACGGCUGcAcAGUGcAdTsdT	antis

2486-2505	9311	CUGGAGUACACACCUACCG	11311	cuGGAGuAcAcAccuAccGdTsdT	sense

2486-2505	9312	CGGUAGGUGUGUACUCCAG	11312	CGGuAGGUGUGuACUCcAGdTsdT	antis

2490-2509	9313	AGUACACACCUACCGCCCG	11313	AGuAcAcAccuAccGcccGdTsdT	sense

2490-2509	9314	CGGGCGGUAGGUGUGUACU	11314	CGGGCGGuAGGUGUGuACUdTsdT	antis

2505-2524	9315	CCCGGCUAACACCACUGGA	11315	cccGGcuAAcAccAcuGGAdTsdT	sense

2505-2524	9316	UCCAGUGGUGUUAGCCGGG	11316	UCcAGUGGUGUuAGCCGGGdTsdT	antis

2508-2527	9317	GGCUAACACCACUGGAAGC	11317	GGcuAAcAccAcuGGAAGcdTsdT	sense

2508-2527	9318	GCUUCCAGUGGUGUUAGCC	11318	GCUUCcAGUGGUGUuAGCCdTsdT	antis

1938-1957	9319	CAGUGUACAGAGUCGCCAG	11319	cAGuGuAcAGAGucGccAGdTsdT	sense

1938-1957	9320	CUGGCGACUCUGUACACUG	11320	CUGGCGACUCUGuAcACUGdTsdT	antis

1985-2004	9321	CCUGUGAUCUAUGUCAAGU	11321	ccuGuGAucuAuGucAAGudTsdT	sense

1985-2004	9322	ACUUGACAUAGAUCACAGG	11322	ACUUGAcAuAGAUcAcAGGdTsdT	antis

2164-2183	9323	UGUUUCAUAUAUCUGUUCU	11323	uGuuucAuAuAucuGuucudTsdT	sense

2164-2183	9324	AGAACAGAUAUAUGAAACA	11324	AGAAcAGAuAuAUGAAAcAdTsdT	antis

2263-2282	9325	GUUGGCUGAAUUGUUGCUA	11325	GuuGGcuGAAuuGuuGcuAdTsdT	sense

2263-2282	9326	UAGCAACAAUUCAGCCAAC	11326	uAGcAAcAAUUcAGCcAACdTsdT	antis

2367-2386	9327	UUAGAGAAAUGAACCCAAA	11327	uuAGAGAAAuGAAcccAAAdTsdT	sense

2367-2386	9328	UUUGGGUUCAUUUCUCUAA	11328	UUUGGGUUcAUUUCUCuAAdTsdT	antis

2395-2414	9329	AUUCAAAUUCCCUCAAAUC	11329	AuucAAAuucccucAAAucdTsdT	sense

2395-2414	9330	GAUUUGAGGGAAUUUGAAU	11330	GAUUUGAGGGAAUUUGAAUdTsdT	antis

1624-1643	9331	UGGCAGCAAGGUAACCACA	11331	uGGcAGcAAGGuAAccAcAdTsdT	sense

1624-1643	9332	UGUGGUUACCUUGCUGCCA	11332	UGUGGUuACCUUGCUGCcAdTsdT	antis

1686-1705	9333	UCAGUUAUACAGACACGAA	11333	ucAGuuAuAcAGAcAcGAAdTsdT	sense

1686-1705	9334	UUCGUGUCUGUAUAACUGA	11334	UUCGUGUCUGuAuAACUGAdTsdT	antis

1979-1998	9335	ACACUCCCUGUGAUCUAUG	11335	AcAcucccuGuGAucuAuGdTsdT	sense

1979-1998	9336	CAUAGAUCACAGGGAGUGU	11336	cAuAGAUcAcAGGGAGUGUdTsdT	antis

2080-2099	9337	GAACCUCUUGUUGGAUCCU	11337	GAAccucuuGuuGGAuccudTsdT	sense

2080-2099	9338	AGGAUCCAACAAGAGGUUC	11338	AGGAUCcAAcAAGAGGUUCdTsdT	antis

2091-2110	9339	UGGAUCCUGAUACAGCUGU	11339	uGGAuccuGAuAcAGcuGudTsdT	sense

2091-2110	9340	ACAGCUGUAUCAGGAUCCA	11340	AcAGCUGuAUcAGGAUCcAdTsdT	antis

2162-2181	9341	AAUGUUUCAUAUAUCUGUU	11341	AAuGuuucAuAuAucuGuudTsdT	sense

2162-2181	9342	AACAGAUAUAUGAAACAUU	11342	AAcAGAuAuAUGAAAcAUUdTsdT	antis

2175-2194	9343	UCUGUUCUCGGUACUACAG	11343	ucuGuucucGGuAcuAcAGdTsdT	sense

2175-2194	9344	CUGUAGUACCGAGAACAGA	11344	CUGuAGuACCGAGAAcAGAdTsdT	antis

2267-2286	9345	GCUGAAUUGUUGCUAGGAC	11345	GcuGAAuuGuuGcuAGGAcdTsdT	sense

2267-2286	9346	GUCCUAGCAACAAUUCAGC	11346	GUCCuAGcAAcAAUUcAGCdTsdT	antis

2309-2328	9347	GGUGUGGAUCAGUUGGUGG	11347	GGuGuGGAucAGuuGGuGGdTsdT	sense

2309-2328	9348	CCACCAACUGAUCCACACC	11348	CcACcAACUGAUCcAcACCdTsdT	antis

2451-2470	9349	CUCCACCAGAGGCAAUUGC	11349	cuccAccAGAGGcAAuuGcdTsdT	sense

2451-2470	9350	GCAAUUGCCUCUGGUGGAG	11350	GcAAUUGCCUCUGGUGGAGdTsdT	antis

1546-1565	9351	CACCUCCUUUGCGGAGAGC	11351	cAccuccuuuGcGGAGAGcdTsdT	sense

1546-1565	9352	GCUCUCCGCAAAGGAGGUG	11352	GCUCUCCGcAAAGGAGGUGdTsdT	antis

1936-1955	9353	GACAGUGUACAGAGUCGCC	11353	GAcAGuGuAcAGAGucGccdTsdT	sense

1936-1955	9354	GGCGACUCUGUACACUGUC	11354	GGCGACUCUGuAcACUGUCdTsdT	antis

1592-1611	9355	UUUGGUAGCAUGAAAGUUA	11355	uuuGGuAGcAuGAAAGuuAdTsdT	sense

1592-1611	9356	UAACUUUCAUGCUACCAAA	11356	uAACUUUcAUGCuACcAAAdTsdT	antis

1620-1639	9357	AAGAUGGCAGCAAGGUAAC	11357	AAGAuGGcAGcAAGGuAAcdTsdT	sense

1620-1639	9358	GUUACCUUGCUGCCAUCUU	11358	GUuACCUUGCUGCcAUCUUdTsdT	antis

1675-1694	9359	GCCACAGGAAGUCAGUUAU	11359	GccAcAGGAAGucAGuuAudTsdT	sense

1675-1694	9360	AUAACUGACUUCCUGUGGC	11360	AuAACUGACUUCCUGUGGCdTsdT	antis

1723-1742	9361	AUUUGGUGUGGUAUAUCAA	11361	AuuuGGuGuGGuAuAucAAdTsdT	sense

1723-1742	9362	UUGAUAUACCACACCAAAU	11362	UUGAuAuACcAcACcAAAUdTsdT	antis

1738-1757	9363	UCAAGCCAAACUUUGUGAU	11363	ucAAGccAAAcuuuGuGAudTsdT	sense

1738-1757	9364	AUCACAAAGUUUGGCUUGA	11364	AUcAcAAAGUUUGGCUUGAdTsdT	antis

1758-1777	9365	CUGGAGAACUGGUUGCCAU	11365	cuGGAGAAcuGGuuGccAudTsdT	sense

1758-1777	9366	AUGGCAACCAGUUCUCCAG	11366	AUGGcAACcAGUUCUCcAGdTsdT	antis

2027-2046	9367	AGUCUAGCCUAUAUCCAUU	11367	AGucuAGccuAuAuccAuudTsdT	sense

2027-2046	9368	AAUGGAUAUAGGCUAGACU	11368	AAUGGAuAuAGGCuAGACUdTsdT	antis

2083-2102	9369	CCUCUUGUUGGAUCCUGAU	11369	ccucuuGuuGGAuccuGAudTsdT	sense

2083-2102	9370	AUCAGGAUCCAACAAGAGG	11370	AUcAGGAUCcAAcAAGAGGdTsdT	antis

2097-2116	9371	CUGAUACAGCUGUAUUAAA	11371	cuGAuAcAGcuGuAuuAAAdTsdT	sense

2097-2116	9372	UUUAAUACAGCUGUAUCAG	11372	UUuAAuAcAGCUGuAUcAGdTsdT	antis

2104-2123	9373	AGCUGUAUUAAAACUCUGU	11373	AGcuGuAuuAAAAcucuGudTsdT	sense

2104-2123	9374	ACAGAGUUUUAAUACAGCU	11374	AcAGAGUUUuAAuAcAGCUdTsdT	antis

2208-2227	9375	UCUUUGGAGCCACUGAUUA	11375	ucuuuGGAGccAcuGAuuAdTsdT	sense

2208-2227	9376	UAAUCAGUGGCUCCAAAGA	11376	uAAUcAGUGGCUCcAAAGAdTsdT	antis

2210-2229	9377	UUUGGAGCCACUGAUUACA	11377	uuuGGAGccAcuGAuuAcAdTsdT	sense

2210-2229	9378	UGUAAUCAGUGGCUCCAAA	11378	UGuAAUcAGUGGCUCcAAAdTsdT	antis

2304-2323	9379	ACAGUGGUGUGGAUCAGUU	11379	AcAGuGGuGuGGAucAGuudTsdT	sense

2304-2323	9380	AACUGAUCCACACCACUGU	11380	AACUGAUCcAcACcACUGUdTsdT	antis

2328-2347	9381	AAAUAAUAAAGGUCCUAGG	11381	AAAuAAuAAAGGuccuAGGdTsdT	sense

2328-2347	9382	CCUAGGACCUUUAUUAUUU	11382	CCuAGGACCUUuAUuAUUUdTsdT	antis

2390-2409	9383	ACAGAAUUCAAAUUCCCUC	11383	AcAGAAuucAAAuucccucdTsdT	sense

2390-2409	9384	GAGGGAAUUUGAAUUCUGU	11384	GAGGGAAUUUGAAUUCUGUdTsdT	antis

2018-2037	9385	CUGUUCAGAAGUCUAGCCU	11385	cuGuucAGAAGucuAGccudTsdT	sense

2018-2037	9386	AGGCUAGACUUCUGAACAG	11386	AGGCuAGACUUCUGAAcAGdTsdT	antis

2338-2357	9387	GGUCCUAGGAACACCAACA	11387	GGuccuAGGAAcAccAAcAdTsdT	sense

2338-2357	9388	UGUUGGUGUUCCUAGGACC	11388	UGUUGGUGUUCCuAGGACCdTsdT	antis

2351-2370	9389	CCAACAAGGGAGCAAAUUA	11389	ccAAcAAGGGAGcAAAuuAdTsdT	sense

2351-2370	9390	UAAUUUGCUCCCUUGUUGG	11390	uAAUUUGCUCCCUUGUUGGdTsdT	antis

2433-2452	9391	AGGUCUUCCGGCCCCGAAC	11391	AGGucuuccGGccccGAAcdTsdT	sense

2433-2452	9392	GUUCGGGGCCGGAAGACCU	11392	GUUCGGGGCCGGAAGACCUdTsdT	antis

2180-2199	9393	UCUCGGUACUACAGGGCAC	11393	ucucGGuAcuAcAGGGcAcdTsdT	sense

2180-2199	9394	GUGCCCUGUAGUACCGAGA	11394	GUGCCCUGuAGuACCGAGAdTsdT	antis

1644-1663	9395	UAGUGGCAACUCCUGGCCA	11395	uAGuGGcAAcuccuGGccAdTsdT	sense

1644-1663	9396	UGGCCAGGAGUUGCCACUA	11396	UGGCcAGGAGUUGCcACuAdTsdT	antis

1827-1846	9397	UGAGAAAGCUAGACCACUG	11397	uGAGAAAGcuAGAccAcuGdTsdT	sense

1827-1846	9398	CAGUGGUCUAGCUUUCUCA	11398	cAGUGGUCuAGCUUUCUcAdTsdT	antis

2098-2117	9399	UGAUACAGCUGUAUUAAAA	11399	uGAuAcAGcuGuAuuAAAAdTsdT	sense

2098-2117	9400	UUUUAAUACAGCUGUAUCA	11400	UUUuAAuAcAGCUGuAUcAdTsdT	antis

2254-2273	9401	AGGCUGUGUGUUGGCUGAA	11401	AGGcuGuGuGuuGGcuGAAdTsdT	sense

2254-2273	9402	UUCAGCCAACACACAGCCU	11402	UUcAGCcAAcAcAcAGCCUdTsdT	antis

1674-1693	9403	GGCCACAGGAAGUCAGUUA	11403	GGccAcAGGAAGucAGuuAdTsdT	sense

1674-1693	9404	UAACUGACUUCCUGUGGCC	11404	uAACUGACUUCCUGUGGCCdTsdT	antis

2495-2514	9405	ACACCUACCGCCCGGCUAA	11405	AcAccuAccGcccGGcuAAdTsdT	sense

2495-2514	9406	UUAGCCGGGCGGUAGGUGU	11406	UuAGCCGGGCGGuAGGUGUdTsdT	antis

1794-1813	9407	ACAAGCGAUUUAAGAACCG	11407	AcAAGcGAuuuAAGAAccGdTsdT	sense

1794-1813	9408	CGGUUCUUAAAUCGCUUGU	11408	CGGUUCUuAAAUCGCUUGUdTsdT	antis

1861-1880	9409	GCGGUAUUUCUUCUACUCG	11409	GcGGuAuuucuucuAcucGdTsdT	sense

1861-1880	9410	CGAGUAGAAGAAAUACCGC	11410	CGAGuAGAAGAAAuACCGCdTsdT	antis

1989-2008	9411	UGAUCUAUGUCAAGUUGUA	11411	uGAucuAuGucAAGuuGuAdTsdT	sense

1989-2008	9412	UACAACUUGACAUAGAUCA	11412	uAcAACUUGAcAuAGAUcAdTsdT	antis

2025-2044	9413	GAAGUCUAGCCUAUAUCCA	11413	GAAGucuAGccuAuAuccAdTsdT	sense

2025-2044	9414	UGGAUAUAGGCUAGACUUC	11414	UGGAuAuAGGCuAGACUUCdTsdT	antis

2028-2047	9415	GUCUAGCCUAUAUCCAUUC	11415	GucuAGccuAuAuccAuucdTsdT	sense

2028-2047	9416	GAAUGGAUAUAGGCUAGAC	11416	GAAUGGAuAuAGGCuAGACdTsdT	antis

2029-2048	9417	UCUAGCCUAUAUCCAUUCC	11417	ucuAGccuAuAuccAuuccdTsdT	sense

2029-2048	9418	GGAAUGGAUAUAGGCUAGA	11418	GGAAUGGAuAuAGGCuAGAdTsdT	antis

2275-2294	9419	GUUGCUAGGACAACCAAUA	11419	GuuGcuAGGAcAAccAAuAdTsdT	sense

2275-2294	9420	UAUUGGUUGUCCUAGCAAC	11420	uAUUGGUUGUCCuAGcAACdTsdT	antis

1593-1612	9421	UUGGUAGCAUGAAAGUUAG	11421	uuGGuAGcAuGAAAGuuAGdTsdT	sense

1593-1612	9422	CUAACUUUCAUGCUACCAA	11422	CuAACUUUcAUGCuACcAAdTsdT	antis

1690-1709	9423	UUAUACAGACACGAAAGUG	11423	uuAuAcAGAcAcGAAAGuGdTsdT	sense

1690-1709	9424	CACUUUCGUGUCUGUAUAA	11424	cACUUUCGUGUCUGuAuAAdTsdT	antis

1795-1814	9425	CAAGCGAUUUAAGAACCGA	11425	cAAGcGAuuuAAGAAccGAdTsdT	sense

1795-1814	9426	UCGGUUCUUAAAUCGCUUG	11426	UCGGUUCUuAAAUCGCUUGdTsdT	antis

1822-1841	9427	GAUCAUGAGAAAGCUAGAC	11427	GAucAuGAGAAAGcuAGAcdTsdT	sense

1822-1841	9428	GUCUAGCUUUCUCAUGAUC	11428	GUCuAGCUUUCUcAUGAUCdTsdT	antis

1901-1920	9429	GUCUACCUUAACCUGGUGC	11429	GucuAccuuAAccuGGuGcdTsdT	sense

1901-1920	9430	GCACCAGGUUAAGGUAGAC	11430	GcACcAGGUuAAGGuAGACdTsdT	antis

1926-1945	9431	AUGUUCCGGAGACAGUGUA	11431	AuGuuccGGAGAcAGuGuAdTsdT	sense

1926-1945	9432	UACACUGUCUCCGGAACAU	11432	uAcACUGUCUCCGGAAcAUdTsdT	antis

1947-1966	9433	GAGUCGCCAGACACUAUAG	11433	GAGucGccAGAcAcuAuAGdTsdT	sense

1947-1966	9434	CUAUAGUGUCUGGCGACUC	11434	CuAuAGUGUCUGGCGACUCdTsdT	antis

1949-1968	9435	GUCGCCAGACACUAUAGUC	11435	GucGccAGAcAcuAuAGucdTsdT	sense

1949-1968	9436	GACUAUAGUGUCUGGCGAC	11436	GACuAuAGUGUCUGGCGACdTsdT	antis

1956-1975	9437	GACACUAUAGUCGAGCCAA	11437	GAcAcuAuAGucGAGccAAdTsdT	sense

1956-1975	9438	UUGGCUCGACUAUAGUGUC	11438	UUGGCUCGACuAuAGUGUCdTsdT	antis

1977-1996	9439	AGACACUCCCUGUGAUCUA	11439	AGAcAcucccuGuGAucuAdTsdT	sense

1977-1996	9440	UAGAUCACAGGGAGUGUCU	11440	uAGAUcAcAGGGAGUGUCUdTsdT	antis

1990-2009	9441	GAUCUAUGUCAAGUUGUAU	11441	GAucuAuGucAAGuuGuAudTsdT	sense

1990-2009	9442	AUACAACUUGACAUAGAUC	11442	AuAcAACUUGAcAuAGAUCdTsdT	antis

2008-2027	9443	UAUGUAUCAGCUGUUCAGA	11443	uAuGuAucAGcuGuucAGAdTsdT	sense

2008-2027	9444	UCUGAACAGCUGAUACAUA	11444	UCUGAAcAGCUGAuAcAuAdTsdT	antis

2047-2066	9445	CUUUGGAAUCUGCCAUCGA	11445	cuuuGGAAucuGccAucGAdTsdT	sense

2047-2066	9446	UCGAUGGCAGAUUCCAAAG	11446	UCGAUGGcAGAUUCcAAAGdTsdT	antis

2187-2206	9447	ACUACAGGGCACCAGAGUU	11447	AcuAcAGGGcAccAGAGuudTsdT	sense

2187-2206	9448	AACUCUGGUGCCCUGUAGU	11448	AACUCUGGUGCCCUGuAGUdTsdT	antis

2307-2326	9449	GUGGUGUGGAUCAGUUGGU	11449	GuGGuGuGGAucAGuuGGudTsdT	sense

2307-2326	9450	ACCAACUGAUCCACACCAC	11450	ACcAACUGAUCcAcACcACdTsdT	antis

2357-2376	9451	AGGGAGCAAAUUAGAGAAA	11451	AGGGAGcAAAuuAGAGAAAdTsdT	sense

2357-2376	9452	UUUCUCUAAUUUGCUCCCU	11452	UUUCUCuAAUUUGCUCCCUdTsdT	antis

2405-2424	9453	CCUCAAAUCAAGGCACAUC	11453	ccucAAAucAAGGcAcAucdTsdT	sense

2405-2424	9454	GAUGUGCCUUGAUUUGAGG	11454	GAUGUGCCUUGAUUUGAGGdTsdT	antis

2483-2502	9455	CUGCUGGAGUACACACCUA	11455	cuGcuGGAGuAcAcAccuAdTsdT	sense

2483-2502	9456	UAGGUGUGUACUCCAGCAG	11456	uAGGUGUGuACUCcAGcAGdTsdT	antis

1629-1648	9457	GCAAGGUAACCACAGUAGU	11457	GcAAGGuAAccAcAGuAGudTsdT	sense

1629-1648	9458	ACUACUGUGGUUACCUUGC	11458	ACuACUGUGGUuACCUUGCdTsdT	antis

1972-1991	9459	CAAGCAGACACUCCCUGUG	11459	cAAGcAGAcAcucccuGuGdTsdT	sense

1972-1991	9460	CACAGGGAGUGUCUGCUUG	11460	cAcAGGGAGUGUCUGCUUGdTsdT	antis

1622-1641	9461	GAUGGCAGCAAGGUAACCA	11461	GAuGGcAGcAAGGuAAccAdTsdT	sense

1622-1641	9462	UGGUUACCUUGCUGCCAUC	11462	UGGUuACCUUGCUGCcAUCdTsdT	antis

1635-1654	9463	UAACCACAGUAGUGGCAAC	11463	uAAccAcAGuAGuGGcAAcdTsdT	sense

1635-1654	9464	GUUGCCACUACUGUGGUUA	11464	GUUGCcACuACUGUGGUuAdTsdT	antis

1790-1809	9465	CAGGACAAGCGAUUUAAGA	11465	cAGGAcAAGcGAuuuAAGAdTsdT	sense

1790-1809	9466	UCUUAAAUCGCUUGUCCUG	11466	UCUuAAAUCGCUUGUCCUGdTsdT	antis

1818-1837	9467	UCCAGAUCAUGAGAAAGCU	11467	uccAGAucAuGAGAAAGcudTsdT	sense

1818-1837	9468	AGCUUUCUCAUGAUCUGGA	11468	AGCUUUCUcAUGAUCUGGAdTsdT	antis

1854-1873	9469	UCCGACUGCGGUAUUUCUU	11469	uccGAcuGcGGuAuuucuudTsdT	sense

1854-1873	9470	AAGAAAUACCGCAGUCGGA	11470	AAGAAAuACCGcAGUCGGAdTsdT	antis

1942-1961	9471	GUACAGAGUCGCCAGACAC	11471	GuAcAGAGucGccAGAcAcdTsdT	sense

1942-1961	9472	GUGUCUGGCGACUCUGUAC	11472	GUGUCUGGCGACUCUGuACdTsdT	antis

1988-2007	9473	GUGAUCUAUGUCAAGUUGU	11473	GuGAucuAuGucAAGuuGudTsdT	sense

1988-2007	9474	ACAACUUGACAUAGAUCAC	11474	AcAACUUGAcAuAGAUcACdTsdT	antis

2055-2074	9475	UCUGCCAUCGAGACAUUAA	11475	ucuGccAucGAGAcAuuAAdTsdT	sense

2055-2074	9476	UUAAUGUCUCGAUGGCAGA	11476	UuAAUGUCUCGAUGGcAGAdTsdT	antis

2217-2236	9477	CCACUGAUUACACGUCCAG	11477	ccAcuGAuuAcAcGuccAGdTsdT	sense

2217-2236	9478	CUGGACGUGUAAUCAGUGG	11478	CUGGACGUGuAAUcAGUGGdTsdT	antis

2235-2254	9479	GUAUAGAUGUAUGGUCUGC	11479	GuAuAGAuGuAuGGucuGcdTsdT	sense

2235-2254	9480	GCAGACCAUACAUCUAUAC	11480	GcAGACcAuAcAUCuAuACdTsdT	antis

2258-2277	9481	UGUGUGUUGGCUGAAUUGU	11481	uGuGuGuuGGcuGAAuuGudTsdT	sense

2258-2277	9482	ACAAUUCAGCCAACACACA	11482	AcAAUUcAGCcAAcAcAcAdTsdT	antis

2269-2288	9483	UGAAUUGUUGCUAGGACAA	11483	uGAAuuGuuGcuAGGAcAAdTsdT	sense

2269-2288	9484	UUGUCCUAGCAACAAUUCA	11484	UUGUCCuAGcAAcAAUUcAdTsdT	antis

2404-2423	9485	CCCUCAAAUCAAGGCACAU	11485	cccucAAAucAAGGcAcAudTsdT	sense

2404-2423	9486	AUGUGCCUUGAUUUGAGGG	11486	AUGUGCCUUGAUUUGAGGGdTsdT	antis

2423-2442	9487	CCUUGGACAAAGGUCUUCC	11487	ccuuGGAcAAAGGucuuccdTsdT	sense

2423-2442	9488	GGAAGACCUUUGUCCAAGG	11488	GGAAGACCUUUGUCcAAGGdTsdT	antis

2455-2474	9489	ACCAGAGGCAAUUGCACUG	11489	AccAGAGGcAAuuGcAcuGdTsdT	sense

2455-2474	9490	CAGUGCAAUUGCCUCUGGU	11490	cAGUGcAAUUGCCUCUGGUdTsdT	antis

1586-1605	9491	UCAGCUUUUGGUAGCAUGA	11491	ucAGcuuuuGGuAGcAuGAdTsdT	sense

1586-1605	9492	UCAUGCUACCAAAAGCUGA	11492	UcAUGCuACcAAAAGCUGAdTsdT	antis

1601-1620	9493	AUGAAAGUUAGCAGAGAUA	11493	AuGAAAGuuAGcAGAGAuAdTsdT	sense

1601-1620	9494	UAUCUCUGCUAACUUUCAU	11494	uAUCUCUGCuAACUUUcAUdTsdT	antis

1621-1640	9495	AGAUGGCAGCAAGGUAACC	11495	AGAuGGcAGcAAGGuAAccdTsdT	sense

1621-1640	9496	GGUUACCUUGCUGCCAUCU	11496	GGUuACCUUGCUGCcAUCUdTsdT	antis

1626-1645	9497	GCAGCAAGGUAACCACAGU	11497	GcAGcAAGGuAAccAcAGudTsdT	sense

1626-1645	9498	ACUGUGGUUACCUUGCUGC	11498	ACUGUGGUuACCUUGCUGCdTsdT	antis

1658-1677	9499	GGCCAGGGUCCUGACAGGC	11499	GGccAGGGuccuGAcAGGcdTsdT	sense

1658-1677	9500	GCCUGUCAGGACCCUGGCC	11500	GCCUGUcAGGACCCUGGCCdTsdT	antis

1683-1702	9501	AAGUCAGUUAUACAGACAC	11501	AAGucAGuuAuAcAGAcAcdTsdT	sense

1683-1702	9502	GUGUCUGUAUAACUGACUU	11502	GUGUCUGuAuAACUGACUUdTsdT	antis

1709-1728	9503	AUUGGAAAUGGAUCAUUUG	11503	AuuGGAAAuGGAucAuuuGdTsdT	sense

1709-1728	9504	CAAAUGAUCCAUUUCCAAU	11504	cAAAUGAUCcAUUUCcAAUdTsdT	antis

1710-1729	9505	UUGGAAAUGGAUCAUUUGG	11505	uuGGAAAuGGAucAuuuGGdTsdT	sense

1710-1729	9506	CCAAAUGAUCCAUUUCCAA	11506	CcAAAUGAUCcAUUUCcAAdTsdT	antis

1726-1745	9507	UGGUGUGGUAUAUCAAGCC	11507	uGGuGuGGuAuAucAAGccdTsdT	sense

1726-1745	9508	GGCUUGAUAUACCACACCA	11508	GGCUUGAuAuACcAcACcAdTsdT	antis

1740-1759	9509	AAGCCAAACUUUGUGAUUC	11509	AAGccAAAcuuuGuGAuucdTsdT	sense

1740-1759	9510	GAAUCACAAAGUUUGGCUU	11510	GAAUcAcAAAGUUUGGCUUdTsdT	antis

1754-1773	9511	GAUUCUGGAGAACUGGUUG	11511	GAuucuGGAGAAcuGGuuGdTsdT	sense

1754-1773	9512	CAACCAGUUCUCCAGAAUC	11512	cAACcAGUUCUCcAGAAUCdTsdT	antis

1755-1774	9513	AUUCUGGAGAACUGGUUGC	11513	AuucuGGAGAAcuGGuuGcdTsdT	sense

1755-1774	9514	GCAACCAGUUCUCCAGAAU	11514	GcAACcAGUUCUCcAGAAUdTsdT	antis

1757-1776	9515	UCUGGAGAACUGGUUGCCA	11515	ucuGGAGAAcuGGuuGccAdTsdT	sense

1757-1776	9516	UGGCAACCAGUUCUCCAGA	11516	UGGcAACcAGUUCUCcAGAdTsdT	antis

1786-1805	9517	UCUACAGGACAAGCGAUUU	11517	ucuAcAGGAcAAGcGAuuudTsdT	sense

1786-1805	9518	AAAUCGCUUGUCCUGUAGA	11518	AAAUCGCUUGUCCUGuAGAdTsdT	antis

1834-1853	9519	GCUAGACCACUGUAACAUA	11519	GcuAGAccAcuGuAAcAuAdTsdT	sense

1834-1853	9520	UAUGUUACAGUGGUCUAGC	11520	uAUGUuAcAGUGGUCuAGCdTsdT	antis

1886-1905	9521	GAGAAGAAAGAUGAGGUCU	11521	GAGAAGAAAGAuGAGGucudTsdT	sense

1886-1905	9522	AGACCUCAUCUUUCUUCUC	11522	AGACCUcAUCUUUCUUCUCdTsdT	antis

1887-1906	9523	AGAAGAAAGAUGAGGUCUA	11523	AGAAGAAAGAuGAGGucuAdTsdT	sense

1887-1906	9524	UAGACCUCAUCUUUCUUCU	11524	uAGACCUcAUCUUUCUUCUdTsdT	antis

1892-1911	9525	AAAGAUGAGGUCUACCUUA	11525	AAAGAuGAGGucuAccuuAdTsdT	sense

1892-1911	9526	UAAGGUAGACCUCAUCUUU	11526	uAAGGuAGACCUcAUCUUUdTsdT	antis

1893-1912	9527	AAGAUGAGGUCUACCUUAA	11527	AAGAuGAGGucuAccuuAAdTsdT	sense

1893-1912	9528	UUAAGGUAGACCUCAUCUU	11528	UuAAGGuAGACCUcAUCUUdTsdT	antis

1925-1944	9529	UAUGUUCCGGAGACAGUGU	11529	uAuGuuccGGAGAcAGuGudTsdT	sense

1925-1944	9530	ACACUGUCUCCGGAACAUA	11530	AcACUGUCUCCGGAAcAuAdTsdT	antis

1937-1956	9531	ACAGUGUACAGAGUCGCCA	11531	AcAGuGuAcAGAGucGccAdTsdT	sense

1937-1956	9532	UGGCGACUCUGUACACUGU	11532	UGGCGACUCUGuAcACUGUdTsdT	antis

1978-1997	9533	GACACUCCCUGUGAUCUAU	11533	GAcAcucccuGuGAucuAudTsdT	sense

1978-1997	9534	AUAGAUCACAGGGAGUGUC	11534	AuAGAUcAcAGGGAGUGUCdTsdT	antis

1980-1999	9535	CACUCCCUGUGAUCUAUGU	11535	cAcucccuGuGAucuAuGudTsdT	sense

1980-1999	9536	ACAUAGAUCACAGGGAGUG	11536	AcAuAGAUcAcAGGGAGUGdTsdT	antis

2005-2024	9537	GUAUAUGUAUCAGCUGUUC	11537	GuAuAuGuAucAGcuGuucdTsdT	sense

2005-2024	9538	GAACAGCUGAUACAUAUAC	11538	GAAcAGCUGAuAcAuAuACdTsdT	antis

2074-2093	9539	ACCACAGAACCUCUUGUUG	11539	AccAcAGAAccucuuGuuGdTsdT	sense

2074-2093	9540	CAACAAGAGGUUCUGUGGU	11540	cAAcAAGAGGUUCUGUGGUdTsdT	antis

2081-2100	9541	AACCUCUUGUUGGAUCCUG	11541	AAccucuuGuuGGAuccuGdTsdT	sense

2081-2100	9542	CAGGAUCCAACAAGAGGUU	11542	cAGGAUCcAAcAAGAGGUUdTsdT	antis

2094-2113	9543	AUCCUGAUACAGCUGUAUU	11543	AuccuGAuAcAGcuGuAuudTsdT	sense

2094-2113	9544	AAUACAGCUGUAUCAGGAU	11544	AAuAcAGCUGuAUcAGGAUdTsdT	antis

2101-2120	9545	UACAGCUGUAUUAAAACUC	11545	uAcAGcuGuAuuAAAAcucdTsdT	sense

2101-2120	9546	GAGUUUUAAUACAGCUGUA	11546	GAGUUUuAAuAcAGCUGuAdTsdT	antis

2138-2157	9547	AAGCAGCUGGUCCGAGGAG	11547	AAGcAGcuGGuccGAGGAGdTsdT	sense

2138-2157	9548	CUCCUCGGACCAGCUGCUU	11548	CUCCUCGGACcAGCUGCUUdTsdT	antis

2161-2180	9549	CAAUGUUUCAUAUAUCUGU	11549	cAAuGuuucAuAuAucuGudTsdT	sense

2161-2180	9550	ACAGAUAUAUGAAACAUUG	11550	AcAGAuAuAUGAAAcAUUGdTsdT	antis

2171-2190	9551	UAUAUCUGUUCUCGGUACU	11551	uAuAucuGuucucGGuAcudTsdT	sense

2171-2190	9552	AGUACCGAGAACAGAUAUA	11552	AGuACCGAGAAcAGAuAuAdTsdT	antis

2178-2197	9553	GUUCUCGGUACUACAGGGC	11553	GuucucGGuAcuAcAGGGcdTsdT	sense

2178-2197	9554	GCCCUGUAGUACCGAGAAC	11554	GCCCUGuAGuACCGAGAACdTsdT	antis

2193-2212	9555	GGGCACCAGAGUUGAUCUU	11555	GGGcAccAGAGuuGAucuudTsdT	sense

2193-2212	9556	AAGAUCAACUCUGGUGCCC	11556	AAGAUcAACUCUGGUGCCCdTsdT	antis

2197-2216	9557	ACCAGAGUUGAUCUUUGGA	11557	AccAGAGuuGAucuuuGGAdTsdT	sense

2197-2216	9558	UCCAAAGAUCAACUCUGGU	11558	UCcAAAGAUcAACUCUGGUdTsdT	antis

2209-2228	9559	CUUUGGAGCCACUGAUUAC	11559	cuuuGGAGccAcuGAuuAcdTsdT	sense

2209-2228	9560	GUAAUCAGUGGCUCCAAAG	11560	GuAAUcAGUGGCUCcAAAGdTsdT	antis

2215-2234	9561	AGCCACUGAUUACACGUCC	11561	AGccAcuGAuuAcAcGuccdTsdT	sense

2215-2234	9562	GGACGUGUAAUCAGUGGCU	11562	GGACGUGuAAUcAGUGGCUdTsdT	antis

2231-2250	9563	UCCAGUAUAGAUGUAUGGU	11563	uccAGuAuAGAuGuAuGGudTsdT	sense

2231-2250	9564	ACCAUACAUCUAUACUGGA	11564	ACcAuAcAUCuAuACUGGAdTsdT	antis

2308-2327	9565	UGGUGUGGAUCAGUUGGUG	11565	uGGuGuGGAucAGuuGGuGdTsdT	sense

2308-2327	9566	CACCAACUGAUCCACACCA	11566	cACcAACUGAUCcAcACcAdTsdT	antis

2334-2353	9567	UAAAGGUCCUAGGAACACC	11567	uAAAGGuccuAGGAAcAccdTsdT	sense

2334-2353	9568	GGUGUUCCUAGGACCUUUA	11568	GGUGUUCCuAGGACCUUuAdTsdT	antis

2336-2355	9569	AAGGUCCUAGGAACACCAA	11569	AAGGuccuAGGAAcAccAAdTsdT	sense

2336-2355	9570	UUGGUGUUCCUAGGACCUU	11570	UUGGUGUUCCuAGGACCUUdTsdT	antis

2337-2356	9571	AGGUCCUAGGAACACCAAC	11571	AGGuccuAGGAAcAccAAcdTsdT	sense

2337-2356	9572	GUUGGUGUUCCUAGGACCU	11572	GUUGGUGUUCCuAGGACCUdTsdT	antis

2343-2362	9573	UAGGAACACCAACAAGGGA	11573	uAGGAAcAccAAcAAGGGAdTsdT	sense

2343-2362	9574	UCCCUUGUUGGUGUUCCUA	11574	UCCCUUGUUGGUGUUCCuAdTsdT	antis

2352-2371	9575	CAACAAGGGAGCAAAUUAG	11575	cAAcAAGGGAGcAAAuuAGdTsdT	sense

2352-2371	9576	CUAAUUUGCUCCCUUGUUG	11576	CuAAUUUGCUCCCUUGUUGdTsdT	antis

2370-2389	9577	GAGAAAUGAACCCAAAUUA	11577	GAGAAAuGAAcccAAAuuAdTsdT	sense

2370-2389	9578	UAAUUUGGGUUCAUUUCUC	11578	uAAUUUGGGUUcAUUUCUCdTsdT	antis

2385-2404	9579	AUUAUACAGAAUUCAAAUU	11579	AuuAuAcAGAAuucAAAuudTsdT	sense

2385-2404	9580	AAUUUGAAUUCUGUAUAAU	11580	AAUUUGAAUUCUGuAuAAUdTsdT	antis

2392-2411	9581	AGAAUUCAAAUUCCCUCAA	11581	AGAAuucAAAuucccucAAdTsdT	sense

2392-2411	9582	UUGAGGGAAUUUGAAUUCU	11582	UUGAGGGAAUUUGAAUUCUdTsdT	antis

2393-2412	9583	GAAUUCAAAUUCCCUCAAA	11583	GAAuucAAAuucccucAAAdTsdT	sense

2393-2412	9584	UUUGAGGGAAUUUGAAUUC	11584	UUUGAGGGAAUUUGAAUUCdTsdT	antis

2403-2422	9585	UCCCUCAAAUCAAGGCACA	11585	ucccucAAAucAAGGcAcAdTsdT	sense

2403-2422	9586	UGUGCCUUGAUUUGAGGGA	11586	UGUGCCUUGAUUUGAGGGAdTsdT	antis

2421-2440	9587	AUCCUUGGACAAAGGUCUU	11587	AuccuuGGAcAAAGGucuudTsdT	sense

2421-2440	9588	AAGACCUUUGUCCAAGGAU	11588	AAGACCUUUGUCcAAGGAUdTsdT	antis

2424-2443	9589	CUUGGACAAAGGUCUUCCG	11589	cuuGGAcAAAGGucuuccGdTsdT	sense

2424-2443	9590	CGGAAGACCUUUGUCCAAG	11590	CGGAAGACCUUUGUCcAAGdTsdT	antis

2454-2473	9591	CACCAGAGGCAAUUGCACU	11591	cAccAGAGGcAAuuGcAcudTsdT	sense

2454-2473	9592	AGUGCAAUUGCCUCUGGUG	11592	AGUGcAAUUGCCUCUGGUGdTsdT	antis

2468-2487	9593	GCACUGUGCAGCCGUCUGC	11593	GcAcuGuGcAGccGucuGcdTsdT	sense

2468-2487	9594	GCAGACGGCUGCACAGUGC	11594	GcAGACGGCUGcAcAGUGCdTsdT	antis

2469-2488	9595	CACUGUGCAGCCGUCUGCU	11595	cAcuGuGcAGccGucuGcudTsdT	sense

2469-2488	9596	AGCAGACGGCUGCACAGUG	11596	AGcAGACGGCUGcAcAGUGdTsdT	antis

2516-2535	9597	CCACUGGAAGCUUGUGCAC	11597	ccAcuGGAAGcuuGuGcAcdTsdT	sense

2516-2535	9598	GUGCACAAGCUUCCAGUGG	11598	GUGcAcAAGCUUCcAGUGGdTsdT	antis

1559-1578	9599	GAGAGCUGCAAGCCAGUGC	11599	GAGAGcuGcAAGccAGuGcdTsdT	sense

1559-1578	9600	GCACUGGCUUGCAGCUCUC	11600	GcACUGGCUUGcAGCUCUCdTsdT	antis

1676-1695	9601	CCACAGGAAGUCAGUUAUA	11601	ccAcAGGAAGucAGuuAuAdTsdT	sense

1676-1695	9602	UAUAACUGACUUCCUGUGG	11602	uAuAACUGACUUCCUGUGGdTsdT	antis

1896-1915	9603	AUGAGGUCUACCUUAACCU	11603	AuGAGGucuAccuuAAccudTsdT	sense

1896-1915	9604	AGGUUAAGGUAGACCUCAU	11604	AGGUuAAGGuAGACCUcAUdTsdT	antis

2262-2281	9605	UGUUGGCUGAAUUGUUGCU	11605	uGuuGGcuGAAuuGuuGcudTsdT	sense

2262-2281	9606	AGCAACAAUUCAGCCAACA	11606	AGcAAcAAUUcAGCcAAcAdTsdT	antis

2270-2289	9607	GAAUUGUUGCUAGGACAAC	11607	GAAuuGuuGcuAGGAcAAcdTsdT	sense

2270-2289	9608	GUUGUCCUAGCAACAAUUC	11608	GUUGUCCuAGcAAcAAUUCdTsdT	antis

1576-1595	9609	GCAGCAGCCUUCAGCUUUU	11609	GcAGcAGccuucAGcuuuudTsdT	sense

1576-1595	9610	AAAAGCUGAAGGCUGCUGC	11610	AAAAGCUGAAGGCUGCUGCdTsdT	antis

1577-1596	9611	CAGCAGCCUUCAGCUUUUG	11611	cAGcAGccuucAGcuuuuGdTsdT	sense

1577-1596	9612	CAAAAGCUGAAGGCUGCUG	11612	cAAAAGCUGAAGGCUGCUGdTsdT	antis

1623-1642	9613	AUGGCAGCAAGGUAACCAC	11613	AuGGcAGcAAGGuAAccAcdTsdT	sense

1623-1642	9614	GUGGUUACCUUGCUGCCAU	11614	GUGGUuACCUUGCUGCcAUdTsdT	antis

1645-1664	9615	AGUGGCAACUCCUGGCCAG	11615	AGuGGcAAcuccuGGccAGdTsdT	sense

1645-1664	9616	CUGGCCAGGAGUUGCCACU	11616	CUGGCcAGGAGUUGCcACUdTsdT	antis

1742-1761	9617	GCCAAACUUUGUGAUUCUG	11617	GccAAAcuuuGuGAuucuGdTsdT	sense

1742-1761	9618	CAGAAUCACAAAGUUUGGC	11618	cAGAAUcAcAAAGUUUGGCdTsdT	antis

1778-1797	9619	AAGAAAGUUCUACAGGACA	11619	AAGAAAGuucuAcAGGAcAdTsdT	sense

1778-1797	9620	UGUCCUGUAGAACUUUCUU	11620	UGUCCUGuAGAACUUUCUUdTsdT	antis

1920-1939	9621	UGGACUAUGUUCCGGAGAC	11621	uGGAcuAuGuuccGGAGAcdTsdT	sense

1920-1939	9622	GUCUCCGGAACAUAGUCCA	11622	GUCUCCGGAAcAuAGUCcAdTsdT	antis

1973-1992	9623	AAGCAGACACUCCCUGUGA	11623	AAGcAGAcAcucccuGuGAdTsdT	sense

1973-1992	9624	UCACAGGGAGUGUCUGCUU	11624	UcAcAGGGAGUGUCUGCUUdTsdT	antis

1984-2003	9625	CCCUGUGAUCUAUGUCAAG	11625	cccuGuGAucuAuGucAAGdTsdT	sense

1984-2003	9626	CUUGACAUAGAUCACAGGG	11626	CUUGAcAuAGAUcAcAGGGdTsdT	antis

2085-2104	9627	UCUUGUUGGAUCCUGAUAC	11627	ucuuGuuGGAuccuGAuAcdTsdT	sense

2085-2104	9628	GUAUCAGGAUCCAACAAGA	11628	GuAUcAGGAUCcAAcAAGAdTsdT	antis

2090-2109	9629	UUGGAUCCUGAUACAGCUG	11629	uuGGAuccuGAuAcAGcuGdTsdT	sense

2090-2109	9630	CAGCUGUAUCAGGAUCCAA	11630	cAGCUGuAUcAGGAUCcAAdTsdT	antis

2170-2189	9631	AUAUAUCUGUUCUCGGUAC	11631	AuAuAucuGuucucGGuAcdTsdT	sense

2170-2189	9632	GUACCGAGAACAGAUAUAU	11632	GuACCGAGAAcAGAuAuAUdTsdT	antis

2200-2219	9633	AGAGUUGAUCUUUGGAGCC	11633	AGAGuuGAucuuuGGAGccdTsdT	sense

2200-2219	9634	GGCUCCAAAGAUCAACUCU	11634	GGCUCcAAAGAUcAACUCUdTsdT	antis

2253-2272	9635	CAGGCUGUGUGUUGGCUGA	11635	cAGGcuGuGuGuuGGcuGAdTsdT	sense

2253-2272	9636	UCAGCCAACACACAGCCUG	11636	UcAGCcAAcAcAcAGCCUGdTsdT	antis

2264-2283	9637	UUGGCUGAAUUGUUGCUAG	11637	uuGGcuGAAuuGuuGcuAGdTsdT	sense

2264-2283	9638	CUAGCAACAAUUCAGCCAA	11638	CuAGcAAcAAUUcAGCcAAdTsdT	antis

2285-2304	9639	CAACCAAUAUUUCCUGGGG	11639	cAAccAAuAuuuccuGGGGdTsdT	sense

2285-2304	9640	CCCCAGGAAAUAUUGGUUG	11640	CCCcAGGAAAuAUUGGUUGdTsdT	antis

2315-2334	9641	GAUCAGUUGGUGGAAAUAA	11641	GAucAGuuGGuGGAAAuAAdTsdT	sense

2315-2334	9642	UUAUUUCCACCAACUGAUC	11642	UuAUUUCcACcAACUGAUCdTsdT	antis

2452-2471	9643	UCCACCAGAGGCAAUUGCA	11643	uccAccAGAGGcAAuuGcAdTsdT	sense

2452-2471	9644	UGCAAUUGCCUCUGGUGGA	11644	UGcAAUUGCCUCUGGUGGAdTsdT	antis

2503-2522	9645	CGCCCGGCUAACACCACUG	11645	cGcccGGcuAAcAccAcuGdTsdT	sense

2503-2522	9646	CAGUGGUGUUAGCCGGGCG	11646	cAGUGGUGUuAGCCGGGCGdTsdT	antis

2504-2523	9647	GCCCGGCUAACACCACUGG	11647	GcccGGcuAAcAccAcuGGdTsdT	sense

2504-2523	9648	CCAGUGGUGUUAGCCGGGC	11648	CcAGUGGUGUuAGCCGGGCdTsdT	antis

1961-1980	9649	UAUAGUCGAGCCAAGCAGA	11649	uAuAGucGAGccAAGcAGAdTsdT	sense

1961-1980	9650	UCUGCUUGGCUCGACUAUA	11650	UCUGCUUGGCUCGACuAuAdTsdT	antis

1699-1718	9651	CACGAAAGUGAUUGGAAAU	11651	cAcGAAAGuGAuuGGAAAudTsdT	sense

1699-1718	9652	AUUUCCAAUCACUUUCGUG	11652	AUUUCcAAUcACUUUCGUGdTsdT	antis

1791-1810	9653	AGGACAAGCGAUUUAAGAA	11653	AGGAcAAGcGAuuuAAGAAdTsdT	sense

1791-1810	9654	UUCUUAAAUCGCUUGUCCU	11654	UUCUuAAAUCGCUUGUCCUdTsdT	antis

1534-1553	9655	GCGACCGAGAACCACCUCC	11655	GcGAccGAGAAccAccuccdTsdT	sense

1534-1553	9656	GGAGGUGGUUCUCGGUCGC	11656	GGAGGUGGUUCUCGGUCGCdTsdT	antis

1899-1918	9657	AGGUCUACCUUAACCUGGU	11657	AGGucuAccuuAAccuGGudTsdT	sense

1899-1918	9658	ACCAGGUUAAGGUAGACCU	11658	ACcAGGUuAAGGuAGACCUdTsdT	antis

1931-1950	9659	CCGGAGACAGUGUACAGAG	11659	ccGGAGAcAGuGuAcAGAGdTsdT	sense

1931-1950	9660	CUCUGUACACUGUCUCCGG	11660	CUCUGuAcACUGUCUCCGGdTsdT	antis

1964-1983	9661	AGUCGAGCCAAGCAGACAC	11661	AGucGAGccAAGcAGAcAcdTsdT	sense

1964-1983	9662	GUGUCUGCUUGGCUCGACU	11662	GUGUCUGCUUGGCUCGACUdTsdT	antis

2056-2075	9663	CUGCCAUCGAGACAUUAAA	11663	cuGccAucGAGAcAuuAAAdTsdT	sense

2056-2075	9664	UUUAAUGUCUCGAUGGCAG	11664	UUuAAUGUCUCGAUGGcAGdTsdT	antis

2155-2174	9665	AGAGCCCAAUGUUUCAUAU	11665	AGAGcccAAuGuuucAuAudTsdT	sense

2155-2174	9666	AUAUGAAACAUUGGGCUCU	11666	AuAUGAAAcAUUGGGCUCUdTsdT	antis

2182-2201	9667	UCGGUACUACAGGGCACCA	11667	ucGGuAcuAcAGGGcAccAdTsdT	sense

2182-2201	9668	UGGUGCCCUGUAGUACCGA	11668	UGGUGCCCUGuAGuACCGAdTsdT	antis

2329-2348	9669	AAUAAUAAAGGUCCUAGGA	11669	AAuAAuAAAGGuccuAGGAdTsdT	sense

2329-2348	9670	UCCUAGGACCUUUAUUAUU	11670	UCCuAGGACCUUuAUuAUUdTsdT	antis

2360-2379	9671	GAGCAAAUUAGAGAAAUGA	11671	GAGcAAAuuAGAGAAAuGAdTsdT	sense

2360-2379	9672	UCAUUUCUCUAAUUUGCUC	11672	UcAUUUCUCuAAUUUGCUCdTsdT	antis

2500-2519	9673	UACCGCCCGGCUAACACCA	11673	uAccGcccGGcuAAcAccAdTsdT	sense

2500-2519	9674	UGGUGUUAGCCGGGCGGUA	11674	UGGUGUuAGCCGGGCGGuAdTsdT	antis

1526-1545	9675	AUGUCGGGGCGACCGAGAA	11675	AuGucGGGGcGAccGAGAAdTsdT	sense

1526-1545	9676	UUCUCGGUCGCCCCGACAU	11676	UUCUCGGUCGCCCCGAcAUdTsdT	antis

1535-1554	9677	CGACCGAGAACCACCUCCU	11677	cGAccGAGAAccAccuccudTsdT	sense

1535-1554	9678	AGGAGGUGGUUCUCGGUCG	11678	AGGAGGUGGUUCUCGGUCGdTsdT	antis

1553-1572	9679	UUUGCGGAGAGCUGCAAGC	11679	uuuGcGGAGAGcuGcAAGcdTsdT	sense

1553-1572	9680	GCUUGCAGCUCUCCGCAAA	11680	GCUUGcAGCUCUCCGcAAAdTsdT	antis

1628-1647	9681	AGCAAGGUAACCACAGUAG	11681	AGcAAGGuAAccAcAGuAGdTsdT	sense

1628-1647	9682	CUACUGUGGUUACCUUGCU	11682	CuACUGUGGUuACCUUGCUdTsdT	antis

1633-1652	9683	GGUAACCACAGUAGUGGCA	11683	GGuAAccAcAGuAGuGGcAdTsdT	sense

1633-1652	9684	UGCCACUACUGUGGUUACC	11684	UGCcACuACUGUGGUuACCdTsdT	antis

1682-1701	9685	GAAGUCAGUUAUACAGACA	11685	GAAGucAGuuAuAcAGAcAdTsdT	sense

1682-1701	9686	UGUCUGUAUAACUGACUUC	11686	UGUCUGuAuAACUGACUUCdTsdT	antis

1684-1703	9687	AGUCAGUUAUACAGACACG	11687	AGucAGuuAuAcAGAcAcGdTsdT	sense

1684-1703	9688	CGUGUCUGUAUAACUGACU	11688	CGUGUCUGuAuAACUGACUdTsdT	antis

1698-1717	9689	ACACGAAAGUGAUUGGAAA	11689	AcAcGAAAGuGAuuGGAAAdTsdT	sense

1698-1717	9690	UUUCCAAUCACUUUCGUGU	11690	UUUCcAAUcACUUUCGUGUdTsdT	antis

1700-1719	9691	ACGAAAGUGAUUGGAAAUG	11691	AcGAAAGuGAuuGGAAAuGdTsdT	sense

1700-1719	9692	CAUUUCCAAUCACUUUCGU	11692	cAUUUCcAAUcACUUUCGUdTsdT	antis

1703-1722	9693	AAAGUGAUUGGAAAUGGAU	11693	AAAGuGAuuGGAAAuGGAudTsdT	sense

1703-1722	9694	AUCCAUUUCCAAUCACUUU	11694	AUCcAUUUCcAAUcACUUUdTsdT	antis

1735-1754	9695	AUAUCAAGCCAAACUUUGU	11695	AuAucAAGccAAAcuuuGudTsdT	sense

1735-1754	9696	ACAAAGUUUGGCUUGAUAU	11696	AcAAAGUUUGGCUUGAuAUdTsdT	antis

1741-1760	9697	AGCCAAACUUUGUGAUUCU	11697	AGccAAAcuuuGuGAuucudTsdT	sense

1741-1760	9698	AGAAUCACAAAGUUUGGCU	11698	AGAAUcAcAAAGUUUGGCUdTsdT	antis

1773-1792	9699	CCAUCAAGAAAGUUCUACA	11699	ccAucAAGAAAGuucuAcAdTsdT	sense

1773-1792	9700	UGUAGAACUUUCUUGAUGG	11700	UGuAGAACUUUCUUGAUGGdTsdT	antis

1774-1793	9701	CAUCAAGAAAGUUCUACAG	11701	cAucAAGAAAGuucuAcAGdTsdT	sense

1774-1793	9702	CUGUAGAACUUUCUUGAUG	11702	CUGuAGAACUUUCUUGAUGdTsdT	antis

1784-1803	9703	GUUCUACAGGACAAGCGAU	11703	GuucuAcAGGAcAAGcGAudTsdT	sense

1784-1803	9704	AUCGCUUGUCCUGUAGAAC	11704	AUCGCUUGUCCUGuAGAACdTsdT	antis

1823-1842	9705	AUCAUGAGAAAGCUAGACC	11705	AucAuGAGAAAGcuAGAccdTsdT	sense

1823-1842	9706	GGUCUAGCUUUCUCAUGAU	11706	GGUCuAGCUUUCUcAUGAUdTsdT	antis

1868-1887	9707	UUCUUCUACUCGAGUGGUG	11707	uucuucuAcucGAGuGGuGdTsdT	sense

1868-1887	9708	CACCACUCGAGUAGAAGAA	11708	cACcACUCGAGuAGAAGAAdTsdT	antis

1876-1895	9709	CUCGAGUGGUGAGAAGAAA	11709	cucGAGuGGuGAGAAGAAAdTsdT	sense

1876-1895	9710	UUUCUUCUCACCACUCGAG	11710	UUUCUUCUcACcACUCGAGdTsdT	antis

1907-1926	9711	CUUAACCUGGUGCUGGACU	11711	cuuAAccuGGuGcuGGAcudTsdT	sense

1907-1926	9712	AGUCCAGCACCAGGUUAAG	11712	AGUCcAGcACcAGGUuAAGdTsdT	antis

1910-1929	9713	AACCUGGUGCUGGACUAUG	11713	AAccuGGuGcuGGAcuAuGdTsdT	sense

1910-1929	9714	CAUAGUCCAGCACCAGGUU	11714	cAuAGUCcAGcACcAGGUUdTsdT	antis

1930-1949	9715	UCCGGAGACAGUGUACAGA	11715	uccGGAGAcAGuGuAcAGAdTsdT	sense

1930-1949	9716	UCUGUACACUGUCUCCGGA	11716	UCUGuAcACUGUCUCCGGAdTsdT	antis

1939-1958	9717	AGUGUACAGAGUCGCCAGA	11717	AGuGuAcAGAGucGccAGAdTsdT	sense

1939-1958	9718	UCUGGCGACUCUGUACACU	11718	UCUGGCGACUCUGuAcACUdTsdT	antis

1940-1959	9719	GUGUACAGAGUCGCCAGAC	11719	GuGuAcAGAGucGccAGAcdTsdT	sense

1940-1959	9720	GUCUGGCGACUCUGUACAC	11720	GUCUGGCGACUCUGuAcACdTsdT	antis

1943-1962	9721	UACAGAGUCGCCAGACACU	11721	uAcAGAGucGccAGAcAcudTsdT	sense

1943-1962	9722	AGUGUCUGGCGACUCUGUA	11722	AGUGUCUGGCGACUCUGuAdTsdT	antis

1946-1965	9723	AGAGUCGCCAGACACUAUA	11723	AGAGucGccAGAcAcuAuAdTsdT	sense

1946-1965	9724	UAUAGUGUCUGGCGACUCU	11724	uAuAGUGUCUGGCGACUCUdTsdT	antis

1948-1967	9725	AGUCGCCAGACACUAUAGU	11725	AGucGccAGAcAcuAuAGudTsdT	sense

1948-1967	9726	ACUAUAGUGUCUGGCGACU	11726	ACuAuAGUGUCUGGCGACUdTsdT	antis

1963-1982	9727	UAGUCGAGCCAAGCAGACA	11727	uAGucGAGccAAGcAGAcAdTsdT	sense

1963-1982	9728	UGUCUGCUUGGCUCGACUA	11728	UGUCUGCUUGGCUCGACuAdTsdT	antis

1987-2006	9729	UGUGAUCUAUGUCAAGUUG	11729	uGuGAucuAuGucAAGuuGdTsdT	sense

1987-2006	9730	CAACUUGACAUAGAUCACA	11730	cAACUUGAcAuAGAUcAcAdTsdT	antis

1991-2010	9731	AUCUAUGUCAAGUUGUAUA	11731	AucuAuGucAAGuuGuAuAdTsdT	sense

1991-2010	9732	UAUACAACUUGACAUAGAU	11732	uAuAcAACUUGAcAuAGAUdTsdT	antis

1992-2011	9733	UCUAUGUCAAGUUGUAUAU	11733	ucuAuGucAAGuuGuAuAudTsdT	sense

1992-2011	9734	AUAUACAACUUGACAUAGA	11734	AuAuAcAACUUGAcAuAGAdTsdT	antis

2000-2019	9735	AAGUUGUAUAUGUAUCAGC	11735	AAGuuGuAuAuGuAucAGcdTsdT	sense

2000-2019	9736	GCUGAUACAUAUACAACUU	11736	GCUGAuAcAuAuAcAACUUdTsdT	antis

2001-2020	9737	AGUUGUAUAUGUAUCAGCU	11737	AGuuGuAuAuGuAucAGcudTsdT	sense

2001-2020	9738	AGCUGAUACAUAUACAACU	11738	AGCUGAuAcAuAuAcAACUdTsdT	antis

2004-2023	9739	UGUAUAUGUAUCAGCUGUU	11739	uGuAuAuGuAucAGcuGuudTsdT	sense

2004-2023	9740	AACAGCUGAUACAUAUACA	11740	AAcAGCUGAuAcAuAuAcAdTsdT	antis

2007-2026	9741	AUAUGUAUCAGCUGUUCAG	11741	AuAuGuAucAGcuGuucAGdTsdT	sense

2007-2026	9742	CUGAACAGCUGAUACAUAU	11742	CUGAAcAGCUGAuAcAuAUdTsdT	antis

2048-2067	9743	UUUGGAAUCUGCCAUCGAG	11743	uuuGGAAucuGccAucGAGdTsdT	sense

2048-2067	9744	CUCGAUGGCAGAUUCCAAA	11744	CUCGAUGGcAGAUUCcAAAdTsdT	antis

2100-2119	9745	AUACAGCUGUAUUAAAACU	11745	AuAcAGcuGuAuuAAAAcudTsdT	sense

2100-2119	9746	AGUUUUAAUACAGCUGUAU	11746	AGUUUuAAuAcAGCUGuAUdTsdT	antis

2107-2126	9747	UGUAUUAAAACUCUGUGAC	11747	uGuAuuAAAAcucuGuGAcdTsdT	sense

2107-2126	9748	GUCACAGAGUUUUAAUACA	11748	GUcAcAGAGUUUuAAuAcAdTsdT	antis

2151-2170	9749	GAGGAGAGCCCAAUGUUUC	11749	GAGGAGAGcccAAuGuuucdTsdT	sense

2151-2170	9750	GAAACAUUGGGCUCUCCUC	11750	GAAAcAUUGGGCUCUCCUCdTsdT	antis

2158-2177	9751	GCCCAAUGUUUCAUAUAUC	11751	GcccAAuGuuucAuAuAucdTsdT	sense

2158-2177	9752	GAUAUAUGAAACAUUGGGC	11752	GAuAuAUGAAAcAUUGGGCdTsdT	antis

2166-2185	9753	UUUCAUAUAUCUGUUCUCG	11753	uuucAuAuAucuGuucucGdTsdT	sense

2166-2185	9754	CGAGAACAGAUAUAUGAAA	11754	CGAGAAcAGAuAuAUGAAAdTsdT	antis

2172-2191	9755	AUAUCUGUUCUCGGUACUA	11755	AuAucuGuucucGGuAcuAdTsdT	sense

2172-2191	9756	UAGUACCGAGAACAGAUAU	11756	uAGuACCGAGAAcAGAuAUdTsdT	antis

2183-2202	9757	CGGUACUACAGGGCACCAG	11757	cGGuAcuAcAGGGcAccAGdTsdT	sense

2183-2202	9758	CUGGUGCCCUGUAGUACCG	11758	CUGGUGCCCUGuAGuACCGdTsdT	antis

2232-2251	9759	CCAGUAUAGAUGUAUGGUC	11759	ccAGuAuAGAuGuAuGGucdTsdT	sense

2232-2251	9760	GACCAUACAUCUAUACUGG	11760	GACcAuAcAUCuAuACUGGdTsdT	antis

2273-2292	9761	UUGUUGCUAGGACAACCAA	11761	uuGuuGcuAGGAcAAccAAdTsdT	sense

2273-2292	9762	UUGGUUGUCCUAGCAACAA	11762	UUGGUUGUCCuAGcAAcAAdTsdT	antis

2274-2293	9763	UGUUGCUAGGACAACCAAU	11763	uGuuGcuAGGAcAAccAAudTsdT	sense

2274-2293	9764	AUUGGUUGUCCUAGCAACA	11764	AUUGGUUGUCCuAGcAAcAdTsdT	antis

2318-2337	9765	CAGUUGGUGGAAAUAAUAA	11765	cAGuuGGuGGAAAuAAuAAdTsdT	sense

2318-2337	9766	UUAUUAUUUCCACCAACUG	11766	UuAUuAUUUCcACcAACUGdTsdT	antis

2361-2380	9767	AGCAAAUUAGAGAAAUGAA	11767	AGcAAAuuAGAGAAAuGAAdTsdT	sense

2361-2380	9768	UUCAUUUCUCUAAUUUGCU	11768	UUcAUUUCUCuAAUUUGCUdTsdT	antis

2380-2399	9769	CCCAAAUUAUACAGAAUUC	11769	cccAAAuuAuAcAGAAuucdTsdT	sense

2380-2399	9770	GAAUUCUGUAUAAUUUGGG	11770	GAAUUCUGuAuAAUUUGGGdTsdT	antis

2400-2419	9771	AAUUCCCUCAAAUCAAGGC	11771	AAuucccucAAAucAAGGcdTsdT	sense

2400-2419	9772	GCCUUGAUUUGAGGGAAUU	11772	GCCUUGAUUUGAGGGAAUUdTsdT	antis

2409-2428	9773	AAAUCAAGGCACAUCCUUG	11773	AAAucAAGGcAcAuccuuGdTsdT	sense

2409-2428	9774	CAAGGAUGUGCCUUGAUUU	11774	cAAGGAUGUGCCUUGAUUUdTsdT	antis

2445-2464	9775	CCCGAACUCCACCAGAGGC	11775	cccGAAcuccAccAGAGGcdTsdT	sense

2445-2464	9776	GCCUCUGGUGGAGUUCGGG	11776	GCCUCUGGUGGAGUUCGGGdTsdT	antis

2479-2498	9777	CCGUCUGCUGGAGUACACA	11777	ccGucuGcuGGAGuAcAcAdTsdT	sense

2479-2498	9778	UGUGUACUCCAGCAGACGG	11778	UGUGuACUCcAGcAGACGGdTsdT	antis

2489-2508	9779	GAGUACACACCUACCGCCC	11779	GAGuAcAcAccuAccGcccdTsdT	sense

2489-2508	9780	GGGCGGUAGGUGUGUACUC	11780	GGGCGGuAGGUGUGuACUCdTsdT	antis

1819-1838	9781	CCAGAUCAUGAGAAAGCUA	11781	ccAGAucAuGAGAAAGcuAdTsdT	sense

1819-1838	9782	UAGCUUUCUCAUGAUCUGG	11782	uAGCUUUCUcAUGAUCUGGdTsdT	antis

2030-2049	9783	CUAGCCUAUAUCCAUUCCU	11783	cuAGccuAuAuccAuuccudTsdT	sense

2030-2049	9784	AGGAAUGGAUAUAGGCUAG	11784	AGGAAUGGAuAuAGGCuAGdTsdT	antis

2154-2173	9785	GAGAGCCCAAUGUUUCAUA	11785	GAGAGcccAAuGuuucAuAdTsdT	sense

2154-2173	9786	UAUGAAACAUUGGGCUCUC	11786	uAUGAAAcAUUGGGCUCUCdTsdT	antis

2184-2203	9787	GGUACUACAGGGCACCAGA	11787	GGuAcuAcAGGGcAccAGAdTsdT	sense

2184-2203	9788	UCUGGUGCCCUGUAGUACC	11788	UCUGGUGCCCUGuAGuACCdTsdT	antis

2190-2209	9789	ACAGGGCACCAGAGUUGAU	11789	AcAGGGcAccAGAGuuGAudTsdT	sense

2190-2209	9790	AUCAACUCUGGUGCCCUGU	11790	AUcAACUCUGGUGCCCUGUdTsdT	antis

2314-2333	9791	GGAUCAGUUGGUGGAAAUA	11791	GGAucAGuuGGuGGAAAuAdTsdT	sense

2314-2333	9792	UAUUUCCACCAACUGAUCC	11792	uAUUUCcACcAACUGAUCCdTsdT	antis

2428-2447	9793	GACAAAGGUCUUCCGGCCC	11793	GAcAAAGGucuuccGGcccdTsdT	sense

2428-2447	9794	GGGCCGGAAGACCUUUGUC	11794	GGGCCGGAAGACCUUUGUCdTsdT	antis

1913-1932	9795	CUGGUGCUGGACUAUGUUC	11795	cuGGuGcuGGAcuAuGuucdTsdT	sense

1913-1932	9796	GAACAUAGUCCAGCACCAG	11796	GAAcAuAGUCcAGcACcAGdTsdT	antis

1530-1549	9797	CGGGGCGACCGAGAACCAC	11797	cGGGGcGAccGAGAAccAcdTsdT	sense

1530-1549	9798	GUGGUUCUCGGUCGCCCCG	11798	GUGGUUCUCGGUCGCCCCGdTsdT	antis

1549-1568	9799	CUCCUUUGCGGAGAGCUGC	11799	cuccuuuGcGGAGAGcuGcdTsdT	sense

1549-1568	9800	GCAGCUCUCCGCAAAGGAG	11800	GcAGCUCUCCGcAAAGGAGdTsdT	antis

1550-1569	9801	UCCUUUGCGGAGAGCUGCA	11801	uccuuuGcGGAGAGcuGcAdTsdT	sense

1550-1569	9802	UGCAGCUCUCCGCAAAGGA	11802	UGcAGCUCUCCGcAAAGGAdTsdT	antis

1610-1629	9803	AGCAGAGAUAAAGAUGGCA	11803	AGcAGAGAuAAAGAuGGcAdTsdT	sense

1610-1629	9804	UGCCAUCUUUAUCUCUGCU	11804	UGCcAUCUUuAUCUCUGCUdTsdT	antis

1642-1661	9805	AGUAGUGGCAACUCCUGGC	11805	AGuAGuGGcAAcuccuGGcdTsdT	sense

1642-1661	9806	GCCAGGAGUUGCCACUACU	11806	GCcAGGAGUUGCcACuACUdTsdT	antis

1643-1662	9807	GUAGUGGCAACUCCUGGCC	11807	GuAGuGGcAAcuccuGGccdTsdT	sense

1643-1662	9808	GGCCAGGAGUUGCCACUAC	11808	GGCcAGGAGUUGCcACuACdTsdT	antis

1696-1715	9809	AGACACGAAAGUGAUUGGA	11809	AGAcAcGAAAGuGAuuGGAdTsdT	sense

1696-1715	9810	UCCAAUCACUUUCGUGUCU	11810	UCcAAUcACUUUCGUGUCUdTsdT	antis

1704-1723	9811	AAGUGAUUGGAAAUGGAUC	11811	AAGuGAuuGGAAAuGGAucdTsdT	sense

1704-1723	9812	GAUCCAUUUCCAAUCACUU	11812	GAUCcAUUUCcAAUcACUUdTsdT	antis

1719-1738	9813	GAUCAUUUGGUGUGGUAUA	11813	GAucAuuuGGuGuGGuAuAdTsdT	sense

1719-1738	9814	UAUACCACACCAAAUGAUC	11814	uAuACcAcACcAAAUGAUCdTsdT	antis

1728-1747	9815	GUGUGGUAUAUCAAGCCAA	11815	GuGuGGuAuAucAAGccAAdTsdT	sense

1728-1747	9816	UUGGCUUGAUAUACCACAC	11816	UUGGCUUGAuAuACcAcACdTsdT	antis

1731-1750	9817	UGGUAUAUCAAGCCAAACU	11817	uGGuAuAucAAGccAAAcudTsdT	sense

1731-1750	9818	AGUUUGGCUUGAUAUACCA	11818	AGUUUGGCUUGAuAuACcAdTsdT	antis

1732-1751	9819	GGUAUAUCAAGCCAAACUU	11819	GGuAuAucAAGccAAAcuudTsdT	sense

1732-1751	9820	AAGUUUGGCUUGAUAUACC	11820	AAGUUUGGCUUGAuAuACCdTsdT	antis

1733-1752	9821	GUAUAUCAAGCCAAACUUU	11821	GuAuAucAAGccAAAcuuudTsdT	sense

1733-1752	9822	AAAGUUUGGCUUGAUAUAC	11822	AAAGUUUGGCUUGAuAuACdTsdT	antis

1768-1787	9823	GGUUGCCAUCAAGAAAGUU	11823	GGuuGccAucAAGAAAGuudTsdT	sense

1768-1787	9824	AACUUUCUUGAUGGCAACC	11824	AACUUUCUUGAUGGcAACCdTsdT	antis

1800-1819	9825	GAUUUAAGAACCGAGAGCU	11825	GAuuuAAGAAccGAGAGcudTsdT	sense

1800-1819	9826	AGCUCUCGGUUCUUAAAUC	11826	AGCUCUCGGUUCUuAAAUCdTsdT	antis

1802-1821	9827	UUUAAGAACCGAGAGCUCC	11827	uuuAAGAAccGAGAGcuccdTsdT	sense

1802-1821	9828	GGAGCUCUCGGUUCUUAAA	11828	GGAGCUCUCGGUUCUuAAAdTsdT	antis

1821-1840	9829	AGAUCAUGAGAAAGCUAGA	11829	AGAucAuGAGAAAGcuAGAdTsdT	sense

1821-1840	9830	UCUAGCUUUCUCAUGAUCU	11830	UCuAGCUUUCUcAUGAUCUdTsdT	antis

1830-1849	9831	GAAAGCUAGACCACUGUAA	11831	GAAAGcuAGAccAcuGuAAdTsdT	sense

1830-1849	9832	UUACAGUGGUCUAGCUUUC	11832	UuAcAGUGGUCuAGCUUUCdTsdT	antis

1831-1850	9833	AAAGCUAGACCACUGUAAC	11833	AAAGcuAGAccAcuGuAAcdTsdT	sense

1831-1850	9834	GUUACAGUGGUCUAGCUUU	11834	GUuAcAGUGGUCuAGCUUUdTsdT	antis

1856-1875	9835	CGACUGCGGUAUUUCUUCU	11835	cGAcuGcGGuAuuucuucudTsdT	sense

1856-1875	9836	AGAAGAAAUACCGCAGUCG	11836	AGAAGAAAuACCGcAGUCGdTsdT	antis

1857-1876	9837	GACUGCGGUAUUUCUUCUA	11837	GAcuGcGGuAuuucuucuAdTsdT	sense

1857-1876	9838	UAGAAGAAAUACCGCAGUC	11838	uAGAAGAAAuACCGcAGUCdTsdT	antis

1875-1894	9839	ACUCGAGUGGUGAGAAGAA	11839	AcucGAGuGGuGAGAAGAAdTsdT	sense

1875-1894	9840	UUCUUCUCACCACUCGAGU	11840	UUCUUCUcACcACUCGAGUdTsdT	antis

1877-1896	9841	UCGAGUGGUGAGAAGAAAG	11841	ucGAGuGGuGAGAAGAAAGdTsdT	sense

1877-1896	9842	CUUUCUUCUCACCACUCGA	11842	CUUUCUUCUcACcACUCGAdTsdT	antis

1897-1916	9843	UGAGGUCUACCUUAACCUG	11843	uGAGGucuAccuuAAccuGdTsdT	sense

1897-1916	9844	CAGGUUAAGGUAGACCUCA	11844	cAGGUuAAGGuAGACCUcAdTsdT	antis

1908-1927	9845	UUAACCUGGUGCUGGACUA	11845	uuAAccuGGuGcuGGAcuAdTsdT	sense

1908-1927	9846	UAGUCCAGCACCAGGUUAA	11846	uAGUCcAGcACcAGGUuAAdTsdT	antis

1923-1942	9847	ACUAUGUUCCGGAGACAGU	11847	AcuAuGuuccGGAGAcAGudTsdT	sense

1923-1942	9848	ACUGUCUCCGGAACAUAGU	11848	ACUGUCUCCGGAAcAuAGUdTsdT	antis

1928-1947	9849	GUUCCGGAGACAGUGUACA	11849	GuuccGGAGAcAGuGuAcAdTsdT	sense

1928-1947	9850	UGUACACUGUCUCCGGAAC	11850	UGuAcACUGUCUCCGGAACdTsdT	antis

1934-1953	9851	GAGACAGUGUACAGAGUCG	11851	GAGAcAGuGuAcAGAGucGdTsdT	sense

1934-1953	9852	CGACUCUGUACACUGUCUC	11852	CGACUCUGuAcACUGUCUCdTsdT	antis

1951-1970	9853	CGCCAGACACUAUAGUCGA	11853	cGccAGAcAcuAuAGucGAdTsdT	sense

1951-1970	9854	UCGACUAUAGUGUCUGGCG	11854	UCGACuAuAGUGUCUGGCGdTsdT	antis

1981-2000	9855	ACUCCCUGUGAUCUAUGUC	11855	AcucccuGuGAucuAuGucdTsdT	sense

1981-2000	9856	GACAUAGAUCACAGGGAGU	11856	GAcAuAGAUcAcAGGGAGUdTsdT	antis

1983-2002	9857	UCCCUGUGAUCUAUGUCAA	11857	ucccuGuGAucuAuGucAAdTsdT	sense

1983-2002	9858	UUGACAUAGAUCACAGGGA	11858	UUGAcAuAGAUcAcAGGGAdTsdT	antis

1994-2013	9859	UAUGUCAAGUUGUAUAUGU	11859	uAuGucAAGuuGuAuAuGudTsdT	sense

1994-2013	9860	ACAUAUACAACUUGACAUA	11860	AcAuAuAcAACUUGAcAuAdTsdT	antis

2003-2022	9861	UUGUAUAUGUAUCAGCUGU	11861	uuGuAuAuGuAucAGcuGudTsdT	sense

2003-2022	9862	ACAGCUGAUACAUAUACAA	11862	AcAGCUGAuAcAuAuAcAAdTsdT	antis

2067-2086	9863	ACAUUAAACCACAGAACCU	11863	AcAuuAAAccAcAGAAccudTsdT	sense

2067-2086	9864	AGGUUCUGUGGUUUAAUGU	11864	AGGUUCUGUGGUUuAAUGUdTsdT	antis

2077-2096	9865	ACAGAACCUCUUGUUGGAU	11865	AcAGAAccucuuGuuGGAudTsdT	sense

2077-2096	9866	AUCCAACAAGAGGUUCUGU	11866	AUCcAAcAAGAGGUUCUGUdTsdT	antis

2079-2098	9867	AGAACCUCUUGUUGGAUCC	11867	AGAAccucuuGuuGGAuccdTsdT	sense

2079-2098	9868	GGAUCCAACAAGAGGUUCU	11868	GGAUCcAAcAAGAGGUUCUdTsdT	antis

2087-2106	9869	UUGUUGGAUCCUGAUACAG	11869	uuGuuGGAuccuGAuAcAGdTsdT	sense

2087-2106	9870	CUGUAUCAGGAUCCAACAA	11870	CUGuAUcAGGAUCcAAcAAdTsdT	antis

2093-2112	9871	GAUCCUGAUACAGCUGUAU	11871	GAuccuGAuAcAGcuGuAudTsdT	sense

2093-2112	9872	AUACAGCUGUAUCAGGAUC	11872	AuAcAGCUGuAUcAGGAUCdTsdT	antis

2099-2118	9873	GAUACAGCUGUAUUAAAAC	11873	GAuAcAGcuGuAuuAAAAcdTsdT	sense

2099-2118	9874	GUUUUAAUACAGCUGUAUC	11874	GUUUuAAuAcAGCUGuAUCdTsdT	antis

2135-2154	9875	GCAAAGCAGCUGGUCCGAG	11875	GcAAAGcAGcuGGuccGAGdTsdT	sense

2135-2154	9876	CUCGGACCAGCUGCUUUGC	11876	CUCGGACcAGCUGCUUUGCdTsdT	antis

2150-2169	9877	CGAGGAGAGCCCAAUGUUU	11877	cGAGGAGAGcccAAuGuuudTsdT	sense

2150-2169	9878	AAACAUUGGGCUCUCCUCG	11878	AAAcAUUGGGCUCUCCUCGdTsdT	antis

2157-2176	9879	AGCCCAAUGUUUCAUAUAU	11879	AGcccAAuGuuucAuAuAudTsdT	sense

2157-2176	9880	AUAUAUGAAACAUUGGGCU	11880	AuAuAUGAAAcAUUGGGCUdTsdT	antis

2198-2217	9881	CCAGAGUUGAUCUUUGGAG	11881	ccAGAGuuGAucuuuGGAGdTsdT	sense

2198-2217	9882	CUCCAAAGAUCAACUCUGG	11882	CUCcAAAGAUcAACUCUGGdTsdT	antis

2199-2218	9883	CAGAGUUGAUCUUUGGAGC	11883	cAGAGuuGAucuuuGGAGcdTsdT	sense

2199-2218	9884	GCUCCAAAGAUCAACUCUG	11884	GCUCcAAAGAUcAACUCUGdTsdT	antis

2216-2235	9885	GCCACUGAUUACACGUCCA	11885	GccAcuGAuuAcAcGuccAdTsdT	sense

2216-2235	9886	UGGACGUGUAAUCAGUGGC	11886	UGGACGUGuAAUcAGUGGCdTsdT	antis

2237-2256	9887	AUAGAUGUAUGGUCUGCAG	11887	AuAGAuGuAuGGucuGcAGdTsdT	sense

2237-2256	9888	CUGCAGACCAUACAUCUAU	11888	CUGcAGACcAuAcAUCuAUdTsdT	antis

2243-2262	9889	GUAUGGUCUGCAGGCUGUG	11889	GuAuGGucuGcAGGcuGuGdTsdT	sense

2243-2262	9890	CACAGCCUGCAGACCAUAC	11890	cAcAGCCUGcAGACcAuACdTsdT	antis

2272-2291	9891	AUUGUUGCUAGGACAACCA	11891	AuuGuuGcuAGGAcAAccAdTsdT	sense

2272-2291	9892	UGGUUGUCCUAGCAACAAU	11892	UGGUUGUCCuAGcAAcAAUdTsdT	antis

2283-2302	9893	GACAACCAAUAUUUCCUGG	11893	GAcAAccAAuAuuuccuGGdTsdT	sense

2283-2302	9894	CCAGGAAAUAUUGGUUGUC	11894	CcAGGAAAuAUUGGUUGUCdTsdT	antis

2291-2310	9895	AUAUUUCCUGGGGACAGUG	11895	AuAuuuccuGGGGAcAGuGdTsdT	sense

2291-2310	9896	CACUGUCCCCAGGAAAUAU	11896	cACUGUCCCcAGGAAAuAUdTsdT	antis

2311-2330	9897	UGUGGAUCAGUUGGUGGAA	11897	uGuGGAucAGuuGGuGGAAdTsdT	sense

2311-2330	9898	UUCCACCAACUGAUCCACA	11898	UUCcACcAACUGAUCcAcAdTsdT	antis

2353-2372	9899	AACAAGGGAGCAAAUUAGA	11899	AAcAAGGGAGcAAAuuAGAdTsdT	sense

2353-2372	9900	UCUAAUUUGCUCCCUUGUU	11900	UCuAAUUUGCUCCCUUGUUdTsdT	antis

2359-2378	9901	GGAGCAAAUUAGAGAAAUG	11901	GGAGcAAAuuAGAGAAAuGdTsdT	sense

2359-2378	9902	CAUUUCUCUAAUUUGCUCC	11902	cAUUUCUCuAAUUUGCUCCdTsdT	antis

2379-2398	9903	ACCCAAAUUAUACAGAAUU	11903	AcccAAAuuAuAcAGAAuudTsdT	sense

2379-2398	9904	AAUUCUGUAUAAUUUGGGU	11904	AAUUCUGuAuAAUUUGGGUdTsdT	antis

2408-2427	9905	CAAAUCAAGGCACAUCCUU	11905	cAAAucAAGGcAcAuccuudTsdT	sense

2408-2427	9906	AAGGAUGUGCCUUGAUUUG	11906	AAGGAUGUGCCUUGAUUUGdTsdT	antis

2412-2431	9907	UCAAGGCACAUCCUUGGAC	11907	ucAAGGcAcAuccuuGGAcdTsdT	sense

2412-2431	9908	GUCCAAGGAUGUGCCUUGA	11908	GUCcAAGGAUGUGCCUUGAdTsdT	antis

2438-2457	9909	UUCCGGCCCCGAACUCCAC	11909	uuccGGccccGAAcuccAcdTsdT	sense

2438-2457	9910	GUGGAGUUCGGGGCCGGAA	11910	GUGGAGUUCGGGGCCGGAAdTsdT	antis

2476-2495	9911	CAGCCGUCUGCUGGAGUAC	11911	cAGccGucuGcuGGAGuAcdTsdT	sense

2476-2495	9912	GUACUCCAGCAGACGGCUG	11912	GuACUCcAGcAGACGGCUGdTsdT	antis

2477-2496	9913	AGCCGUCUGCUGGAGUACA	11913	AGccGucuGcuGGAGuAcAdTsdT	sense

2477-2496	9914	UGUACUCCAGCAGACGGCU	11914	UGuACUCcAGcAGACGGCUdTsdT	antis

2478-2497	9915	GCCGUCUGCUGGAGUACAC	11915	GccGucuGcuGGAGuAcAcdTsdT	sense

2478-2497	9916	GUGUACUCCAGCAGACGGC	11916	GUGuACUCcAGcAGACGGCdTsdT	antis

2484-2503	9917	UGCUGGAGUACACACCUAC	11917	uGcuGGAGuAcAcAccuAcdTsdT	sense

2484-2503	9918	GUAGGUGUGUACUCCAGCA	11918	GuAGGUGUGuACUCcAGcAdTsdT	antis

1527-1546	9919	UGUCGGGGCGACCGAGAAC	11919	uGucGGGGcGAccGAGAAcdTsdT	sense

1527-1546	9920	GUUCUCGGUCGCCCCGACA	11920	GUUCUCGGUCGCCCCGAcAdTsdT	antis

1531-1550	9921	GGGGCGACCGAGAACCACC	11921	GGGGcGAccGAGAAccAccdTsdT	sense

1531-1550	9922	GGUGGUUCUCGGUCGCCCC	11922	GGUGGUUCUCGGUCGCCCCdTsdT	antis

1536-1555	9923	GACCGAGAACCACCUCCUU	11923	GAccGAGAAccAccuccuudTsdT	sense

1536-1555	9924	AAGGAGGUGGUUCUCGGUC	11924	AAGGAGGUGGUUCUCGGUCdTsdT	antis

1542-1561	9925	GAACCACCUCCUUUGCGGA	11925	GAAccAccuccuuuGcGGAdTsdT	sense

1542-1561	9926	UCCGCAAAGGAGGUGGUUC	11926	UCCGcAAAGGAGGUGGUUCdTsdT	antis

1552-1571	9927	CUUUGCGGAGAGCUGCAAG	11927	cuuuGcGGAGAGcuGcAAGdTsdT	sense

1552-1571	9928	CUUGCAGCUCUCCGCAAAG	11928	CUUGcAGCUCUCCGcAAAGdTsdT	antis

1556-1575	9929	GCGGAGAGCUGCAAGCCAG	11929	GcGGAGAGcuGcAAGccAGdTsdT	sense

1556-1575	9930	CUGGCUUGCAGCUCUCCGC	11930	CUGGCUUGcAGCUCUCCGCdTsdT	antis

1564-1583	9931	CUGCAAGCCAGUGCAGCAG	11931	cuGcAAGccAGuGcAGcAGdTsdT	sense

1564-1583	9932	CUGCUGCACUGGCUUGCAG	11932	CUGCUGcACUGGCUUGcAGdTsdT	antis

1572-1591	9933	CAGUGCAGCAGCCUUCAGC	11933	cAGuGcAGcAGccuucAGcdTsdT	sense

1572-1591	9934	GCUGAAGGCUGCUGCACUG	11934	GCUGAAGGCUGCUGcACUGdTsdT	antis

1578-1597	9935	AGCAGCCUUCAGCUUUUGG	11935	AGcAGccuucAGcuuuuGGdTsdT	sense

1578-1597	9936	CCAAAAGCUGAAGGCUGCU	11936	CcAAAAGCUGAAGGCUGCUdTsdT	antis

1579-1598	9937	GCAGCCUUCAGCUUUUGGU	11937	GcAGccuucAGcuuuuGGudTsdT	sense

1579-1598	9938	ACCAAAAGCUGAAGGCUGC	11938	ACcAAAAGCUGAAGGCUGCdTsdT	antis

1581-1600	9939	AGCCUUCAGCUUUUGGUAG	11939	AGccuucAGcuuuuGGuAGdTsdT	sense

1581-1600	9940	CUACCAAAAGCUGAAGGCU	11940	CuACcAAAAGCUGAAGGCUdTsdT	antis

1582-1601	9941	GCCUUCAGCUUUUGGUAGC	11941	GccuucAGcuuuuGGuAGcdTsdT	sense

1582-1601	9942	GCUACCAAAAGCUGAAGGC	11942	GCuACcAAAAGCUGAAGGCdTsdT	antis

1585-1604	9943	UUCAGCUUUUGGUAGCAUG	11943	uucAGcuuuuGGuAGcAuGdTsdT	sense

1585-1604	9944	CAUGCUACCAAAAGCUGAA	11944	cAUGCuACcAAAAGCUGAAdTsdT	antis

1587-1606	9945	CAGCUUUUGGUAGCAUGAA	11945	cAGcuuuuGGuAGcAuGAAdTsdT	sense

1587-1606	9946	UUCAUGCUACCAAAAGCUG	11946	UUcAUGCuACcAAAAGCUGdTsdT	antis

1588-1607	9947	AGCUUUUGGUAGCAUGAAA	11947	AGcuuuuGGuAGcAuGAAAdTsdT	sense

1588-1607	9948	UUUCAUGCUACCAAAAGCU	11948	UUUcAUGCuACcAAAAGCUdTsdT	antis

1598-1617	9949	AGCAUGAAAGUUAGCAGAG	11949	AGcAuGAAAGuuAGcAGAGdTsdT	sense

1598-1617	9950	CUCUGCUAACUUUCAUGCU	11950	CUCUGCuAACUUUcAUGCUdTsdT	antis

1602-1621	9951	UGAAAGUUAGCAGAGAUAA	11951	uGAAAGuuAGcAGAGAuAAdTsdT	sense

1602-1621	9952	UUAUCUCUGCUAACUUUCA	11952	UuAUCUCUGCuAACUUUcAdTsdT	antis

1618-1637	9953	UAAAGAUGGCAGCAAGGUA	11953	uAAAGAuGGcAGcAAGGuAdTsdT	sense

1618-1637	9954	UACCUUGCUGCCAUCUUUA	11954	uACCUUGCUGCcAUCUUuAdTsdT	antis

1619-1638	9955	AAAGAUGGCAGCAAGGUAA	11955	AAAGAuGGcAGcAAGGuAAdTsdT	sense

1619-1638	9956	UUACCUUGCUGCCAUCUUU	11956	UuACCUUGCUGCcAUCUUUdTsdT	antis

1625-1644	9957	GGCAGCAAGGUAACCACAG	11957	GGcAGcAAGGuAAccAcAGdTsdT	sense

1625-1644	9958	CUGUGGUUACCUUGCUGCC	11958	CUGUGGUuACCUUGCUGCCdTsdT	antis

1627-1646	9959	CAGCAAGGUAACCACAGUA	11959	cAGcAAGGuAAccAcAGuAdTsdT	sense

1627-1646	9960	UACUGUGGUUACCUUGCUG	11960	uACUGUGGUuACCUUGCUGdTsdT	antis

1636-1655	9961	AACCACAGUAGUGGCAACU	11961	AAccAcAGuAGuGGcAAcudTsdT	sense

1636-1655	9962	AGUUGCCACUACUGUGGUU	11962	AGUUGCcACuACUGUGGUUdTsdT	antis

1637-1656	9963	ACCACAGUAGUGGCAACUC	11963	AccAcAGuAGuGGcAAcucdTsdT	sense

1637-1656	9964	GAGUUGCCACUACUGUGGU	11964	GAGUUGCcACuACUGUGGUdTsdT	antis

1646-1665	9965	GUGGCAACUCCUGGCCAGG	11965	GuGGcAAcuccuGGccAGGdTsdT	sense

1646-1665	9966	CCUGGCCAGGAGUUGCCAC	11966	CCUGGCcAGGAGUUGCcACdTsdT	antis

1648-1667	9967	GGCAACUCCUGGCCAGGGU	11967	GGcAAcuccuGGccAGGGudTsdT	sense

1648-1667	9968	ACCCUGGCCAGGAGUUGCC	11968	ACCCUGGCcAGGAGUUGCCdTsdT	antis

1649-1668	9969	GCAACUCCUGGCCAGGGUC	11969	GcAAcuccuGGccAGGGucdTsdT	sense

1649-1668	9970	GACCCUGGCCAGGAGUUGC	11970	GACCCUGGCcAGGAGUUGCdTsdT	antis

1651-1670	9971	AACUCCUGGCCAGGGUCCU	11971	AAcuccuGGccAGGGuccudTsdT	sense

1651-1670	9972	AGGACCCUGGCCAGGAGUU	11972	AGGACCCUGGCcAGGAGUUdTsdT	antis

1666-1685	9973	UCCUGACAGGCCACAGGAA	11973	uccuGAcAGGccAcAGGAAdTsdT	sense

1666-1685	9974	UUCCUGUGGCCUGUCAGGA	11974	UUCCUGUGGCCUGUcAGGAdTsdT	antis

1667-1686	9975	CCUGACAGGCCACAGGAAG	11975	ccuGAcAGGccAcAGGAAGdTsdT	sense

1667-1686	9976	CUUCCUGUGGCCUGUCAGG	11976	CUUCCUGUGGCCUGUcAGGdTsdT	antis

1669-1688	9977	UGACAGGCCACAGGAAGUC	11977	uGAcAGGccAcAGGAAGucdTsdT	sense

1669-1688	9978	GACUUCCUGUGGCCUGUCA	11978	GACUUCCUGUGGCCUGUcAdTsdT	antis

1670-1689	9979	GACAGGCCACAGGAAGUCA	11979	GAcAGGccAcAGGAAGucAdTsdT	sense

1670-1689	9980	UGACUUCCUGUGGCCUGUC	11980	UGACUUCCUGUGGCCUGUCdTsdT	antis

1685-1704	9981	GUCAGUUAUACAGACACGA	11981	GucAGuuAuAcAGAcAcGAdTsdT	sense

1685-1704	9982	UCGUGUCUGUAUAACUGAC	11982	UCGUGUCUGuAuAACUGACdTsdT	antis

1687-1706	9983	CAGUUAUACAGACACGAAA	11983	cAGuuAuAcAGAcAcGAAAdTsdT	sense

1687-1706	9984	UUUCGUGUCUGUAUAACUG	11984	UUUCGUGUCUGuAuAACUGdTsdT	antis

1689-1708	9985	GUUAUACAGACACGAAAGU	11985	GuuAuAcAGAcAcGAAAGudTsdT	sense

1689-1708	9986	ACUUUCGUGUCUGUAUAAC	11986	ACUUUCGUGUCUGuAuAACdTsdT	antis

1691-1710	9987	UAUACAGACACGAAAGUGA	11987	uAuAcAGAcAcGAAAGuGAdTsdT	sense

1691-1710	9988	UCACUUUCGUGUCUGUAUA	11988	UcACUUUCGUGUCUGuAuAdTsdT	antis

1693-1712	9989	UACAGACACGAAAGUGAUU	11989	uAcAGAcAcGAAAGuGAuudTsdT	sense

1693-1712	9990	AAUCACUUUCGUGUCUGUA	11990	AAUcACUUUCGUGUCUGuAdTsdT	antis

1701-1720	9991	CGAAAGUGAUUGGAAAUGG	11991	cGAAAGuGAuuGGAAAuGGdTsdT	sense

1701-1720	9992	CCAUUUCCAAUCACUUUCG	11992	CcAUUUCcAAUcACUUUCGdTsdT	antis

1707-1726	9993	UGAUUGGAAAUGGAUCAUU	11993	uGAuuGGAAAuGGAucAuudTsdT	sense

1707-1726	9994	AAUGAUCCAUUUCCAAUCA	11994	AAUGAUCcAUUUCcAAUcAdTsdT	antis

1717-1736	9995	UGGAUCAUUUGGUGUGGUA	11995	uGGAucAuuuGGuGuGGuAdTsdT	sense

1717-1736	9996	UACCACACCAAAUGAUCCA	11996	uACcAcACcAAAUGAUCcAdTsdT	antis

1721-1740	9997	UCAUUUGGUGUGGUAUAUC	11997	ucAuuuGGuGuGGuAuAucdTsdT	sense

1721-1740	9998	GAUAUACCACACCAAAUGA	11998	GAuAuACcAcACcAAAUGAdTsdT	antis

1729-1748	9999	UGUGGUAUAUCAAGCCAAA	11999	uGuGGuAuAucAAGccAAAdTsdT	sense

1729-1748	10000	UUUGGCUUGAUAUACCACA	12000	UUUGGCUUGAuAuACcAcAdTsdT	antis

1734-1753	10001	UAUAUCAAGCCAAACUUUG	12001	uAuAucAAGccAAAcuuuGdTsdT	sense

1734-1753	10002	CAAAGUUUGGCUUGAUAUA	12002	cAAAGUUUGGCUUGAuAuAdTsdT	antis

1736-1755	10003	UAUCAAGCCAAACUUUGUG	12003	uAucAAGccAAAcuuuGuGdTsdT	sense

1736-1755	10004	CACAAAGUUUGGCUUGAUA	12004	cAcAAAGUUUGGCUUGAuAdTsdT	antis

1737-1756	10005	AUCAAGCCAAACUUUGUGA	12005	AucAAGccAAAcuuuGuGAdTsdT	sense

1737-1756	10006	UCACAAAGUUUGGCUUGAU	12006	UcAcAAAGUUUGGCUUGAUdTsdT	antis

1749-1768	10007	UUUGUGAUUCUGGAGAACU	12007	uuuGuGAuucuGGAGAAcudTsdT	sense

1749-1768	10008	AGUUCUCCAGAAUCACAAA	12008	AGUUCUCcAGAAUcAcAAAdTsdT	antis

1759-1778	10009	UGGAGAACUGGUUGCCAUC	12009	uGGAGAAcuGGuuGccAucdTsdT	sense

1759-1778	10010	GAUGGCAACCAGUUCUCCA	12010	GAUGGcAACcAGUUCUCcAdTsdT	antis

1760-1779	10011	GGAGAACUGGUUGCCAUCA	12011	GGAGAAcuGGuuGccAucAdTsdT	sense

1760-1779	10012	UGAUGGCAACCAGUUCUCC	12012	UGAUGGcAACcAGUUCUCCdTsdT	antis

1767-1786	10013	UGGUUGCCAUCAAGAAAGU	12013	uGGuuGccAucAAGAAAGudTsdT	sense

1767-1786	10014	ACUUUCUUGAUGGCAACCA	12014	ACUUUCUUGAUGGcAACcAdTsdT	antis

1769-1788	10015	GUUGCCAUCAAGAAAGUUC	12015	GuuGccAucAAGAAAGuucdTsdT	sense

1769-1788	10016	GAACUUUCUUGAUGGCAAC	12016	GAACUUUCUUGAUGGcAACdTsdT	antis

1770-1789	10017	UUGCCAUCAAGAAAGUUCU	12017	uuGccAucAAGAAAGuucudTsdT	sense

1770-1789	10018	AGAACUUUCUUGAUGGCAA	12018	AGAACUUUCUUGAUGGcAAdTsdT	antis

1775-1794	10019	AUCAAGAAAGUUCUACAGG	12019	AucAAGAAAGuucuAcAGGdTsdT	sense

1775-1794	10020	CCUGUAGAACUUUCUUGAU	12020	CCUGuAGAACUUUCUUGAUdTsdT	antis

1783-1802	10021	AGUUCUACAGGACAAGCGA	12021	AGuucuAcAGGAcAAGcGAdTsdT	sense

1783-1802	10022	UCGCUUGUCCUGUAGAACU	12022	UCGCUUGUCCUGuAGAACUdTsdT	antis

1787-1806	10023	CUACAGGACAAGCGAUUUA	12023	cuAcAGGAcAAGcGAuuuAdTsdT	sense

1787-1806	10024	UAAAUCGCUUGUCCUGUAG	12024	uAAAUCGCUUGUCCUGuAGdTsdT	antis

1806-1825	10025	AGAACCGAGAGCUCCAGAU	12025	AGAAccGAGAGcuccAGAudTsdT	sense

1806-1825	10026	AUCUGGAGCUCUCGGUUCU	12026	AUCUGGAGCUCUCGGUUCUdTsdT	antis

1810-1829	10027	CCGAGAGCUCCAGAUCAUG	12027	ccGAGAGcuccAGAucAuGdTsdT	sense

1810-1829	10028	CAUGAUCUGGAGCUCUCGG	12028	cAUGAUCUGGAGCUCUCGGdTsdT	antis

1815-1834	10029	AGCUCCAGAUCAUGAGAAA	12029	AGcuccAGAucAuGAGAAAdTsdT	sense

1815-1834	10030	UUUCUCAUGAUCUGGAGCU	12030	UUUCUcAUGAUCUGGAGCUdTsdT	antis

1816-1835	10031	GCUCCAGAUCAUGAGAAAG	12031	GcuccAGAucAuGAGAAAGdTsdT	sense

1816-1835	10032	CUUUCUCAUGAUCUGGAGC	12032	CUUUCUcAUGAUCUGGAGCdTsdT	antis

1817-1836	10033	CUCCAGAUCAUGAGAAAGC	12033	cuccAGAucAuGAGAAAGcdTsdT	sense

1817-1836	10034	GCUUUCUCAUGAUCUGGAG	12034	GCUUUCUcAUGAUCUGGAGdTsdT	antis

1820-1839	10035	CAGAUCAUGAGAAAGCUAG	12035	cAGAucAuGAGAAAGcuAGdTsdT	sense

1820-1839	10036	CUAGCUUUCUCAUGAUCUG	12036	CuAGCUUUCUcAUGAUCUGdTsdT	antis

1824-1843	10037	UCAUGAGAAAGCUAGACCA	12037	ucAuGAGAAAGcuAGAccAdTsdT	sense

1824-1843	10038	UGGUCUAGCUUUCUCAUGA	12038	UGGUCuAGCUUUCUcAUGAdTsdT	antis

1825-1844	10039	CAUGAGAAAGCUAGACCAC	12039	cAuGAGAAAGcuAGAccAcdTsdT	sense

1825-1844	10040	GUGGUCUAGCUUUCUCAUG	12040	GUGGUCuAGCUUUCUcAUGdTsdT	antis

1826-1845	10041	AUGAGAAAGCUAGACCACU	12041	AuGAGAAAGcuAGAccAcudTsdT	sense

1826-1845	10042	AGUGGUCUAGCUUUCUCAU	12042	AGUGGUCuAGCUUUCUcAUdTsdT	antis

1858-1877	10043	ACUGCGGUAUUUCUUCUAC	12043	AcuGcGGuAuuucuucuAcdTsdT	sense

1858-1877	10044	GUAGAAGAAAUACCGCAGU	12044	GuAGAAGAAAuACCGcAGUdTsdT	antis

1866-1885	10045	AUUUCUUCUACUCGAGUGG	12045	AuuucuucuAcucGAGuGGdTsdT	sense

1866-1885	10046	CCACUCGAGUAGAAGAAAU	12046	CcACUCGAGuAGAAGAAAUdTsdT	antis

1869-1888	10047	UCUUCUACUCGAGUGGUGA	12047	ucuucuAcucGAGuGGuGAdTsdT	sense

1869-1888	10048	UCACCACUCGAGUAGAAGA	12048	UcACcACUCGAGuAGAAGAdTsdT	antis

1878-1897	10049	CGAGUGGUGAGAAGAAAGA	12049	cGAGuGGuGAGAAGAAAGAdTsdT	sense

1878-1897	10050	UCUUUCUUCUCACCACUCG	12050	UCUUUCUUCUcACcACUCGdTsdT	antis

1890-1909	10051	AGAAAGAUGAGGUCUACCU	12051	AGAAAGAuGAGGucuAccudTsdT	sense

1890-1909	10052	AGGUAGACCUCAUCUUUCU	12052	AGGuAGACCUcAUCUUUCUdTsdT	antis

1891-1910	10053	GAAAGAUGAGGUCUACCUU	12053	GAAAGAuGAGGucuAccuudTsdT	sense

1891-1910	10054	AAGGUAGACCUCAUCUUUC	12054	AAGGuAGACCUcAUCUUUCdTsdT	antis

1898-1917	10055	GAGGUCUACCUUAACCUGG	12055	GAGGucuAccuuAAccuGGdTsdT	sense

1898-1917	10056	CCAGGUUAAGGUAGACCUC	12056	CcAGGUuAAGGuAGACCUCdTsdT	antis

1903-1922	10057	CUACCUUAACCUGGUGCUG	12057	cuAccuuAAccuGGuGcuGdTsdT	sense

1903-1922	10058	CAGCACCAGGUUAAGGUAG	12058	cAGcACcAGGUuAAGGuAGdTsdT	antis

1911-1930	10059	ACCUGGUGCUGGACUAUGU	12059	AccuGGuGcuGGAcuAuGudTsdT	sense

1911-1930	10060	ACAUAGUCCAGCACCAGGU	12060	AcAuAGUCcAGcACcAGGUdTsdT	antis

1912-1931	10061	CCUGGUGCUGGACUAUGUU	12061	ccuGGuGcuGGAcuAuGuudTsdT	sense

1912-1931	10062	AACAUAGUCCAGCACCAGG	12062	AAcAuAGUCcAGcACcAGGdTsdT	antis

1915-1934	10063	GGUGCUGGACUAUGUUCCG	12063	GGuGcuGGAcuAuGuuccGdTsdT	sense

1915-1934	10064	CGGAACAUAGUCCAGCACC	12064	CGGAAcAuAGUCcAGcACCdTsdT	antis

1929-1948	10065	UUCCGGAGACAGUGUACAG	12065	uuccGGAGAcAGuGuAcAGdTsdT	sense

1929-1948	10066	CUGUACACUGUCUCCGGAA	12066	CUGuAcACUGUCUCCGGAAdTsdT	antis

1933-1952	10067	GGAGACAGUGUACAGAGUC	12067	GGAGAcAGuGuAcAGAGucdTsdT	sense

1933-1952	10068	GACUCUGUACACUGUCUCC	12068	GACUCUGuAcACUGUCUCCdTsdT	antis

1935-1954	10069	AGACAGUGUACAGAGUCGC	12069	AGAcAGuGuAcAGAGucGcdTsdT	sense

1935-1954	10070	GCGACUCUGUACACUGUCU	12070	GCGACUCUGuAcACUGUCUdTsdT	antis

1941-1960	10071	UGUACAGAGUCGCCAGACA	12071	uGuAcAGAGucGccAGAcAdTsdT	sense

1941-1960	10072	UGUCUGGCGACUCUGUACA	12072	UGUCUGGCGACUCUGuAcAdTsdT	antis

1944-1963	10073	ACAGAGUCGCCAGACACUA	12073	AcAGAGucGccAGAcAcuAdTsdT	sense

1944-1963	10074	UAGUGUCUGGCGACUCUGU	12074	uAGUGUCUGGCGACUCUGUdTsdT	antis

1945-1964	10075	CAGAGUCGCCAGACACUAU	12075	cAGAGucGccAGAcAcuAudTsdT	sense

1945-1964	10076	AUAGUGUCUGGCGACUCUG	12076	AuAGUGUCUGGCGACUCUGdTsdT	antis

1965-1984	10077	GUCGAGCCAAGCAGACACU	12077	GucGAGccAAGcAGAcAcudTsdT	sense

1965-1984	10078	AGUGUCUGCUUGGCUCGAC	12078	AGUGUCUGCUUGGCUCGACdTsdT	antis

1966-1985	10079	UCGAGCCAAGCAGACACUC	12079	ucGAGccAAGcAGAcAcucdTsdT	sense

1966-1985	10080	GAGUGUCUGCUUGGCUCGA	12080	GAGUGUCUGCUUGGCUCGAdTsdT	antis

1967-1986	10081	CGAGCCAAGCAGACACUCC	12081	cGAGccAAGcAGAcAcuccdTsdT	sense

1967-1986	10082	GGAGUGUCUGCUUGGCUCG	12082	GGAGUGUCUGCUUGGCUCGdTsdT	antis

1970-1989	10083	GCCAAGCAGACACUCCCUG	12083	GccAAGcAGAcAcucccuGdTsdT	sense

1970-1989	10084	CAGGGAGUGUCUGCUUGGC	12084	cAGGGAGUGUCUGCUUGGCdTsdT	antis

1971-1990	10085	CCAAGCAGACACUCCCUGU	12085	ccAAGcAGAcAcucccuGudTsdT	sense

1971-1990	10086	ACAGGGAGUGUCUGCUUGG	12086	AcAGGGAGUGUCUGCUUGGdTsdT	antis

1974-1993	10087	AGCAGACACUCCCUGUGAU	12087	AGcAGAcAcucccuGuGAudTsdT	sense

1974-1993	10088	AUCACAGGGAGUGUCUGCU	12088	AUcAcAGGGAGUGUCUGCUdTsdT	antis

1975-1994	10089	GCAGACACUCCCUGUGAUC	12089	GcAGAcAcucccuGuGAucdTsdT	sense

1975-1994	10090	GAUCACAGGGAGUGUCUGC	12090	GAUcAcAGGGAGUGUCUGCdTsdT	antis

1986-2005	10091	CUGUGAUCUAUGUCAAGUU	12091	cuGuGAucuAuGucAAGuudTsdT	sense

1986-2005	10092	AACUUGACAUAGAUCACAG	12092	AACUUGAcAuAGAUcAcAGdTsdT	antis

1993-2012	10093	CUAUGUCAAGUUGUAUAUG	12093	cuAuGucAAGuuGuAuAuGdTsdT	sense

1993-2012	10094	CAUAUACAACUUGACAUAG	12094	cAuAuAcAACUUGAcAuAGdTsdT	antis

1995-2014	10095	AUGUCAAGUUGUAUAUGUA	12095	AuGucAAGuuGuAuAuGuAdTsdT	sense

1995-2014	10096	UACAUAUACAACUUGACAU	12096	uAcAuAuAcAACUUGAcAUdTsdT	antis

1996-2015	10097	UGUCAAGUUGUAUAUGUAU	12097	uGucAAGuuGuAuAuGuAudTsdT	sense

1996-2015	10098	AUACAUAUACAACUUGACA	12098	AuAcAuAuAcAACUUGAcAdTsdT	antis

1999-2018	10099	CAAGUUGUAUAUGUAUCAG	12099	cAAGuuGuAuAuGuAucAGdTsdT	sense

1999-2018	10100	CUGAUACAUAUACAACUUG	12100	CUGAuAcAuAuAcAACUUGdTsdT	antis

2009-2028	10101	AUGUAUCAGCUGUUCAGAA	12101	AuGuAucAGcuGuucAGAAdTsdT	sense

2009-2028	10102	UUCUGAACAGCUGAUACAU	12102	UUCUGAAcAGCUGAuAcAUdTsdT	antis

2010-2029	10103	UGUAUCAGCUGUUCAGAAG	12103	uGuAucAGcuGuucAGAAGdTsdT	sense

2010-2029	10104	CUUCUGAACAGCUGAUACA	12104	CUUCUGAAcAGCUGAuAcAdTsdT	antis

2016-2035	10105	AGCUGUUCAGAAGUCUAGC	12105	AGcuGuucAGAAGucuAGcdTsdT	sense

2016-2035	10106	GCUAGACUUCUGAACAGCU	12106	GCuAGACUUCUGAAcAGCUdTsdT	antis

2035-2054	10107	CUAUAUCCAUUCCUUUGGA	12107	cuAuAuccAuuccuuuGGAdTsdT	sense

2035-2054	10108	UCCAAAGGAAUGGAUAUAG	12108	UCcAAAGGAAUGGAuAuAGdTsdT	antis

2036-2055	10109	UAUAUCCAUUCCUUUGGAA	12109	uAuAuccAuuccuuuGGAAdTsdT	sense

2036-2055	10110	UUCCAAAGGAAUGGAUAUA	12110	UUCcAAAGGAAUGGAuAuAdTsdT	antis

2046-2065	10111	CCUUUGGAAUCUGCCAUCG	12111	ccuuuGGAAucuGccAucGdTsdT	sense

2046-2065	10112	CGAUGGCAGAUUCCAAAGG	12112	CGAUGGcAGAUUCcAAAGGdTsdT	antis

2049-2068	10113	UUGGAAUCUGCCAUCGAGA	12113	uuGGAAucuGccAucGAGAdTsdT	sense

2049-2068	10114	UCUCGAUGGCAGAUUCCAA	12114	UCUCGAUGGcAGAUUCcAAdTsdT	antis

2051-2070	10115	GGAAUCUGCCAUCGAGACA	12115	GGAAucuGccAucGAGAcAdTsdT	sense

2051-2070	10116	UGUCUCGAUGGCAGAUUCC	12116	UGUCUCGAUGGcAGAUUCCdTsdT	antis

2068-2087	10117	CAUUAAACCACAGAACCUC	12117	cAuuAAAccAcAGAAccucdTsdT	sense

2068-2087	10118	GAGGUUCUGUGGUUUAAUG	12118	GAGGUUCUGUGGUUuAAUGdTsdT	antis

2070-2089	10119	UUAAACCACAGAACCUCUU	12119	uuAAAccAcAGAAccucuudTsdT	sense

2070-2089	10120	AAGAGGUUCUGUGGUUUAA	12120	AAGAGGUUCUGUGGUUuAAdTsdT	antis

2071-2090	10121	UAAACCACAGAACCUCUUG	12121	uAAAccAcAGAAccucuuGdTsdT	sense

2071-2090	10122	CAAGAGGUUCUGUGGUUUA	12122	cAAGAGGUUCUGUGGUUuAdTsdT	antis

2073-2092	10123	AACCACAGAACCUCUUGUU	12123	AAccAcAGAAccucuuGuudTsdT	sense

2073-2092	10124	AACAAGAGGUUCUGUGGUU	12124	AAcAAGAGGUUCUGUGGUUdTsdT	antis

2075-2094	10125	CCACAGAACCUCUUGUUGG	12125	ccAcAGAAccucuuGuuGGdTsdT	sense

2075-2094	10126	CCAACAAGAGGUUCUGUGG	12126	CcAAcAAGAGGUUCUGUGGdTsdT	antis

2076-2095	10127	CACAGAACCUCUUGUUGGA	12127	cAcAGAAccucuuGuuGGAdTsdT	sense

2076-2095	10128	UCCAACAAGAGGUUCUGUG	12128	UCcAAcAAGAGGUUCUGUGdTsdT	antis

2078-2097	10129	CAGAACCUCUUGUUGGAUC	12129	cAGAAccucuuGuuGGAucdTsdT	sense

2078-2097	10130	GAUCCAACAAGAGGUUCUG	12130	GAUCcAAcAAGAGGUUCUGdTsdT	antis

2084-2103	10131	CUCUUGUUGGAUCCUGAUA	12131	cucuuGuuGGAuccuGAuAdTsdT	sense

2084-2103	10132	UAUCAGGAUCCAACAAGAG	12132	uAUcAGGAUCcAAcAAGAGdTsdT	antis

2086-2105	10133	CUUGUUGGAUCCUGAUACA	12133	cuuGuuGGAuccuGAuAcAdTsdT	sense

2086-2105	10134	UGUAUCAGGAUCCAACAAG	12134	UGuAUcAGGAUCcAAcAAGdTsdT	antis

2095-2114	10135	UCCUGAUACAGCUGUAUUA	12135	uccuGAuAcAGcuGuAuuAdTsdT	sense

2095-2114	10136	UAAUACAGCUGUAUCAGGA	12136	uAAuAcAGCUGuAUcAGGAdTsdT	antis

2102-2121	10137	ACAGCUGUAUUAAAACUCU	12137	AcAGcuGuAuuAAAAcucudTsdT	sense

2102-2121	10138	AGAGUUUUAAUACAGCUGU	12138	AGAGUUUuAAuAcAGCUGUdTsdT	antis

2103-2122	10139	CAGCUGUAUUAAAACUCUG	12139	cAGcuGuAuuAAAAcucuGdTsdT	sense

2103-2122	10140	CAGAGUUUUAAUACAGCUG	12140	cAGAGUUUuAAuAcAGCUGdTsdT	antis

2105-2124	10141	GCUGUAUUAAAACUCUGUG	12141	GcuGuAuuAAAAcucuGuGdTsdT	sense

2105-2124	10142	CACAGAGUUUUAAUACAGC	12142	cAcAGAGUUUuAAuAcAGCdTsdT	antis

2106-2125	10143	CUGUAUUAAAACUCUGUGA	12143	cuGuAuuAAAAcucuGuGAdTsdT	sense

2106-2125	10144	UCACAGAGUUUUAAUACAG	12144	UcAcAGAGUUUuAAuAcAGdTsdT	antis

2108-2127	10145	GUAUUAAAACUCUGUGACU	12145	GuAuuAAAAcucuGuGAcudTsdT	sense

2108-2127	10146	AGUCACAGAGUUUUAAUAC	12146	AGUcAcAGAGUUUuAAuACdTsdT	antis

2115-2134	10147	AACUCUGUGACUUUGGAAG	12147	AAcucuGuGAcuuuGGAAGdTsdT	sense

2115-2134	10148	CUUCCAAAGUCACAGAGUU	12148	CUUCcAAAGUcAcAGAGUUdTsdT	antis

2120-2139	10149	UGUGACUUUGGAAGUGCAA	12149	uGuGAcuuuGGAAGuGcAAdTsdT	sense

2120-2139	10150	UUGCACUUCCAAAGUCACA	12150	UUGcACUUCcAAAGUcAcAdTsdT	antis

2124-2143	10151	ACUUUGGAAGUGCAAAGCA	12151	AcuuuGGAAGuGcAAAGcAdTsdT	sense

2124-2143	10152	UGCUUUGCACUUCCAAAGU	12152	UGCUUUGcACUUCcAAAGUdTsdT	antis

2132-2151	10153	AGUGCAAAGCAGCUGGUCC	12153	AGuGcAAAGcAGcuGGuccdTsdT	sense

2132-2151	10154	GGACCAGCUGCUUUGCACU	12154	GGACcAGCUGCUUUGcACUdTsdT	antis

2134-2153	10155	UGCAAAGCAGCUGGUCCGA	12155	uGcAAAGcAGcuGGuccGAdTsdT	sense

2134-2153	10156	UCGGACCAGCUGCUUUGCA	12156	UCGGACcAGCUGCUUUGcAdTsdT	antis

2136-2155	10157	CAAAGCAGCUGGUCCGAGG	12157	cAAAGcAGcuGGuccGAGGdTsdT	sense

2136-2155	10158	CCUCGGACCAGCUGCUUUG	12158	CCUCGGACcAGCUGCUUUGdTsdT	antis

2139-2158	10159	AGCAGCUGGUCCGAGGAGA	12159	AGcAGcuGGuccGAGGAGAdTsdT	sense

2139-2158	10160	UCUCCUCGGACCAGCUGCU	12160	UCUCCUCGGACcAGCUGCUdTsdT	antis

2140-2159	10161	GCAGCUGGUCCGAGGAGAG	12161	GcAGcuGGuccGAGGAGAGdTsdT	sense

2140-2159	10162	CUCUCCUCGGACCAGCUGC	12162	CUCUCCUCGGACcAGCUGCdTsdT	antis

2141-2160	10163	CAGCUGGUCCGAGGAGAGC	12163	cAGcuGGuccGAGGAGAGcdTsdT	sense

2141-2160	10164	GCUCUCCUCGGACCAGCUG	12164	GCUCUCCUCGGACcAGCUGdTsdT	antis

2142-2161	10165	AGCUGGUCCGAGGAGAGCC	12165	AGcuGGuccGAGGAGAGccdTsdT	sense

2142-2161	10166	GGCUCUCCUCGGACCAGCU	12166	GGCUCUCCUCGGACcAGCUdTsdT	antis

2146-2165	10167	GGUCCGAGGAGAGCCCAAU	12167	GGuccGAGGAGAGcccAAudTsdT	sense

2146-2165	10168	AUUGGGCUCUCCUCGGACC	12168	AUUGGGCUCUCCUCGGACCdTsdT	antis

2147-2166	10169	GUCCGAGGAGAGCCCAAUG	12169	GuccGAGGAGAGcccAAuGdTsdT	sense

2147-2166	10170	CAUUGGGCUCUCCUCGGAC	12170	cAUUGGGCUCUCCUCGGACdTsdT	antis

2160-2179	10171	CCAAUGUUUCAUAUAUCUG	12171	ccAAuGuuucAuAuAucuGdTsdT	sense

2160-2179	10172	CAGAUAUAUGAAACAUUGG	12172	cAGAuAuAUGAAAcAUUGGdTsdT	antis

2189-2208	10173	UACAGGGCACCAGAGUUGA	12173	uAcAGGGcAccAGAGuuGAdTsdT	sense

2189-2208	10174	UCAACUCUGGUGCCCUGUA	12174	UcAACUCUGGUGCCCUGuAdTsdT	antis

2191-2210	10175	CAGGGCACCAGAGUUGAUC	12175	cAGGGcAccAGAGuuGAucdTsdT	sense

2191-2210	10176	GAUCAACUCUGGUGCCCUG	12176	GAUcAACUCUGGUGCCCUGdTsdT	antis

2194-2213	10177	GGCACCAGAGUUGAUCUUU	12177	GGcAccAGAGuuGAucuuudTsdT	sense

2194-2213	10178	AAAGAUCAACUCUGGUGCC	12178	AAAGAUcAACUCUGGUGCCdTsdT	antis

2195-2214	10179	GCACCAGAGUUGAUCUUUG	12179	GcAccAGAGuuGAucuuuGdTsdT	sense

2195-2214	10180	CAAAGAUCAACUCUGGUGC	12180	cAAAGAUcAACUCUGGUGCdTsdT	antis

2196-2215	10181	CACCAGAGUUGAUCUUUGG	12181	cAccAGAGuuGAucuuuGGdTsdT	sense

2196-2215	10182	CCAAAGAUCAACUCUGGUG	12182	CcAAAGAUcAACUCUGGUGdTsdT	antis

2201-2220	10183	GAGUUGAUCUUUGGAGCCA	12183	GAGuuGAucuuuGGAGccAdTsdT	sense

2201-2220	10184	UGGCUCCAAAGAUCAACUC	12184	UGGCUCcAAAGAUcAACUCdTsdT	antis

2211-2230	10185	UUGGAGCCACUGAUUACAC	12185	uuGGAGccAcuGAuuAcAcdTsdT	sense

2211-2230	10186	GUGUAAUCAGUGGCUCCAA	12186	GUGuAAUcAGUGGCUCcAAdTsdT	antis

2234-2253	10187	AGUAUAGAUGUAUGGUCUG	12187	AGuAuAGAuGuAuGGucuGdTsdT	sense

2234-2253	10188	CAGACCAUACAUCUAUACU	12188	cAGACcAuAcAUCuAuACUdTsdT	antis

2238-2257	10189	UAGAUGUAUGGUCUGCAGG	12189	uAGAuGuAuGGucuGcAGGdTsdT	sense

2238-2257	10190	CCUGCAGACCAUACAUCUA	12190	CCUGcAGACcAuAcAUCuAdTsdT	antis

2240-2259	10191	GAUGUAUGGUCUGCAGGCU	12191	GAuGuAuGGucuGcAGGcudTsdT	sense

2240-2259	10192	AGCCUGCAGACCAUACAUC	12192	AGCCUGcAGACcAuAcAUCdTsdT	antis

2241-2260	10193	AUGUAUGGUCUGCAGGCUG	12193	AuGuAuGGucuGcAGGcuGdTsdT	sense

2241-2260	10194	CAGCCUGCAGACCAUACAU	12194	cAGCCUGcAGACcAuAcAUdTsdT	antis

2242-2261	10195	UGUAUGGUCUGCAGGCUGU	12195	uGuAuGGucuGcAGGcuGudTsdT	sense

2242-2261	10196	ACAGCCUGCAGACCAUACA	12196	AcAGCCUGcAGACcAuAcAdTsdT	antis

2249-2268	10197	UCUGCAGGCUGUGUGUUGG	12197	ucuGcAGGcuGuGuGuuGGdTsdT	sense

2249-2268	10198	CCAACACACAGCCUGCAGA	12198	CcAAcAcAcAGCCUGcAGAdTsdT	antis

2255-2274	10199	GGCUGUGUGUUGGCUGAAU	12199	GGcuGuGuGuuGGcuGAAudTsdT	sense

2255-2274	10200	AUUCAGCCAACACACAGCC	12200	AUUcAGCcAAcAcAcAGCCdTsdT	antis

2256-2275	10201	GCUGUGUGUUGGCUGAAUU	12201	GcuGuGuGuuGGcuGAAuudTsdT	sense

2256-2275	10202	AAUUCAGCCAACACACAGC	12202	AAUUcAGCcAAcAcAcAGCdTsdT	antis

2257-2276	10203	CUGUGUGUUGGCUGAAUUG	12203	cuGuGuGuuGGcuGAAuuGdTsdT	sense

2257-2276	10204	CAAUUCAGCCAACACACAG	12204	cAAUUcAGCcAAcAcAcAGdTsdT	antis

2259-2278	10205	GUGUGUUGGCUGAAUUGUU	12205	GuGuGuuGGcuGAAuuGuudTsdT	sense

2259-2278	10206	AACAAUUCAGCCAACACAC	12206	AAcAAUUcAGCcAAcAcACdTsdT	antis

2260-2279	10207	UGUGUUGGCUGAAUUGUUG	12207	uGuGuuGGcuGAAuuGuuGdTsdT	sense

2260-2279	10208	CAACAAUUCAGCCAACACA	12208	cAAcAAUUcAGCcAAcAcAdTsdT	antis

2271-2290	10209	AAUUGUUGCUAGGACAACC	12209	AAuuGuuGcuAGGAcAAccdTsdT	sense

2271-2290	10210	GGUUGUCCUAGCAACAAUU	12210	GGUUGUCCuAGcAAcAAUUdTsdT	antis

2280-2299	10211	UAGGACAACCAAUAUUUCC	12211	uAGGAcAAccAAuAuuuccdTsdT	sense

2280-2299	10212	GGAAAUAUUGGUUGUCCUA	12212	GGAAAuAUUGGUUGUCCuAdTsdT	antis

2284-2303	10213	ACAACCAAUAUUUCCUGGG	12213	AcAAccAAuAuuuccuGGGdTsdT	sense

2284-2303	10214	CCCAGGAAAUAUUGGUUGU	12214	CCcAGGAAAuAUUGGUUGUdTsdT	antis

2287-2306	10215	ACCAAUAUUUCCUGGGGAC	12215	AccAAuAuuuccuGGGGAcdTsdT	sense

2287-2306	10216	GUCCCCAGGAAAUAUUGGU	12216	GUCCCcAGGAAAuAUUGGUdTsdT	antis

2288-2307	10217	CCAAUAUUUCCUGGGGACA	12217	ccAAuAuuuccuGGGGAcAdTsdT	sense

2288-2307	10218	UGUCCCCAGGAAAUAUUGG	12218	UGUCCCcAGGAAAuAUUGGdTsdT	antis

2289-2308	10219	CAAUAUUUCCUGGGGACAG	12219	cAAuAuuuccuGGGGAcAGdTsdT	sense

2289-2308	10220	CUGUCCCCAGGAAAUAUUG	12220	CUGUCCCcAGGAAAuAUUGdTsdT	antis

2290-2309	10221	AAUAUUUCCUGGGGACAGU	12221	AAuAuuuccuGGGGAcAGudTsdT	sense

2290-2309	10222	ACUGUCCCCAGGAAAUAUU	12222	ACUGUCCCcAGGAAAuAUUdTsdT	antis

2292-2311	10223	UAUUUCCUGGGGACAGUGG	12223	uAuuuccuGGGGAcAGuGGdTsdT	sense

2292-2311	10224	CCACUGUCCCCAGGAAAUA	12224	CcACUGUCCCcAGGAAAuAdTsdT	antis

2299-2318	10225	UGGGGACAGUGGUGUGGAU	12225	uGGGGAcAGuGGuGuGGAudTsdT	sense

2299-2318	10226	AUCCACACCACUGUCCCCA	12226	AUCcAcACcACUGUCCCcAdTsdT	antis

2303-2322	10227	GACAGUGGUGUGGAUCAGU	12227	GAcAGuGGuGuGGAucAGudTsdT	sense

2303-2322	10228	ACUGAUCCACACCACUGUC	12228	ACUGAUCcAcACcACUGUCdTsdT	antis

2310-2329	10229	GUGUGGAUCAGUUGGUGGA	12229	GuGuGGAucAGuuGGuGGAdTsdT	sense

2310-2329	10230	UCCACCAACUGAUCCACAC	12230	UCcACcAACUGAUCcAcACdTsdT	antis

2316-2335	10231	AUCAGUUGGUGGAAAUAAU	12231	AucAGuuGGuGGAAAuAAudTsdT	sense

2316-2335	10232	AUUAUUUCCACCAACUGAU	12232	AUuAUUUCcACcAACUGAUdTsdT	antis

2324-2343	10233	GUGGAAAUAAUAAAGGUCC	12233	GuGGAAAuAAuAAAGGuccdTsdT	sense

2324-2343	10234	GGACCUUUAUUAUUUCCAC	12234	GGACCUUuAUuAUUUCcACdTsdT	antis

2327-2346	10235	GAAAUAAUAAAGGUCCUAG	12235	GAAAuAAuAAAGGuccuAGdTsdT	sense

2327-2346	10236	CUAGGACCUUUAUUAUUUC	12236	CuAGGACCUUuAUuAUUUCdTsdT	antis

2333-2352	10237	AUAAAGGUCCUAGGAACAC	12237	AuAAAGGuccuAGGAAcAcdTsdT	sense

2333-2352	10238	GUGUUCCUAGGACCUUUAU	12238	GUGUUCCuAGGACCUUuAUdTsdT	antis

2335-2354	10239	AAAGGUCCUAGGAACACCA	12239	AAAGGuccuAGGAAcAccAdTsdT	sense

2335-2354	10240	UGGUGUUCCUAGGACCUUU	12240	UGGUGUUCCuAGGACCUUUdTsdT	antis

2341-2360	10241	CCUAGGAACACCAACAAGG	12241	ccuAGGAAcAccAAcAAGGdTsdT	sense

2341-2360	10242	CCUUGUUGGUGUUCCUAGG	12242	CCUUGUUGGUGUUCCuAGGdTsdT	antis

2345-2364	10243	GGAACACCAACAAGGGAGC	12243	GGAAcAccAAcAAGGGAGcdTsdT	sense

2345-2364	10244	GCUCCCUUGUUGGUGUUCC	12244	GCUCCCUUGUUGGUGUUCCdTsdT	antis

2356-2375	10245	AAGGGAGCAAAUUAGAGAA	12245	AAGGGAGcAAAuuAGAGAAdTsdT	sense

2356-2375	10246	UUCUCUAAUUUGCUCCCUU	12246	UUCUCuAAUUUGCUCCCUUdTsdT	antis

2358-2377	10247	GGGAGCAAAUUAGAGAAAU	12247	GGGAGcAAAuuAGAGAAAudTsdT	sense

2358-2377	10248	AUUUCUCUAAUUUGCUCCC	12248	AUUUCUCuAAUUUGCUCCCdTsdT	antis

2364-2383	10249	AAAUUAGAGAAAUGAACCC	12249	AAAuuAGAGAAAuGAAcccdTsdT	sense

2364-2383	10250	GGGUUCAUUUCUCUAAUUU	12250	GGGUUcAUUUCUCuAAUUUdTsdT	antis

2365-2384	10251	AAUUAGAGAAAUGAACCCA	12251	AAuuAGAGAAAuGAAcccAdTsdT	sense

2365-2384	10252	UGGGUUCAUUUCUCUAAUU	12252	UGGGUUcAUUUCUCuAAUUdTsdT	antis

2368-2387	10253	UAGAGAAAUGAACCCAAAU	12253	uAGAGAAAuGAAcccAAAudTsdT	sense

2368-2387	10254	AUUUGGGUUCAUUUCUCUA	12254	AUUUGGGUUcAUUUCUCuAdTsdT	antis

2369-2388	10255	AGAGAAAUGAACCCAAAUU	12255	AGAGAAAuGAAcccAAAuudTsdT	sense

2369-2388	10256	AAUUUGGGUUCAUUUCUCU	12256	AAUUUGGGUUcAUUUCUCUdTsdT	antis

2371-2390	10257	AGAAAUGAACCCAAAUUAU	12257	AGAAAuGAAcccAAAuuAudTsdT	sense

2371-2390	10258	AUAAUUUGGGUUCAUUUCU	12258	AuAAUUUGGGUUcAUUUCUdTsdT	antis

2372-2391	10259	GAAAUGAACCCAAAUUAUA	12259	GAAAuGAAcccAAAuuAuAdTsdT	sense

2372-2391	10260	UAUAAUUUGGGUUCAUUUC	12260	uAuAAUUUGGGUUcAUUUCdTsdT	antis

2374-2393	10261	AAUGAACCCAAAUUAUACA	12261	AAuGAAcccAAAuuAuAcAdTsdT	sense

2374-2393	10262	UGUAUAAUUUGGGUUCAUU	12262	UGuAuAAUUUGGGUUcAUUdTsdT	antis

2375-2394	10263	AUGAACCCAAAUUAUACAG	12263	AuGAAcccAAAuuAuAcAGdTsdT	sense

2375-2394	10264	CUGUAUAAUUUGGGUUCAU	12264	CUGuAuAAUUUGGGUUcAUdTsdT	antis

2381-2400	10265	CCAAAUUAUACAGAAUUCA	12265	ccAAAuuAuAcAGAAuucAdTsdT	sense

2381-2400	10266	UGAAUUCUGUAUAAUUUGG	12266	UGAAUUCUGuAuAAUUUGGdTsdT	antis

2386-2405	10267	UUAUACAGAAUUCAAAUUC	12267	uuAuAcAGAAuucAAAuucdTsdT	sense

2386-2405	10268	GAAUUUGAAUUCUGUAUAA	12268	GAAUUUGAAUUCUGuAuAAdTsdT	antis

2387-2406	10269	UAUACAGAAUUCAAAUUCC	12269	uAuAcAGAAuucAAAuuccdTsdT	sense

2387-2406	10270	GGAAUUUGAAUUCUGUAUA	12270	GGAAUUUGAAUUCUGuAuAdTsdT	antis

2388-2407	10271	AUACAGAAUUCAAAUUCCC	12271	AuAcAGAAuucAAAuucccdTsdT	sense

2388-2407	10272	GGGAAUUUGAAUUCUGUAU	12272	GGGAAUUUGAAUUCUGuAUdTsdT	antis

2396-2415	10273	UUCAAAUUCCCUCAAAUCA	12273	uucAAAuucccucAAAucAdTsdT	sense

2396-2415	10274	UGAUUUGAGGGAAUUUGAA	12274	UGAUUUGAGGGAAUUUGAAdTsdT	antis

2398-2417	10275	CAAAUUCCCUCAAAUCAAG	12275	cAAAuucccucAAAucAAGdTsdT	sense

2398-2417	10276	CUUGAUUUGAGGGAAUUUG	12276	CUUGAUUUGAGGGAAUUUGdTsdT	antis

2399-2418	10277	AAAUUCCCUCAAAUCAAGG	12277	AAAuucccucAAAucAAGGdTsdT	sense

2399-2418	10278	CCUUGAUUUGAGGGAAUUU	12278	CCUUGAUUUGAGGGAAUUUdTsdT	antis

2406-2425	10279	CUCAAAUCAAGGCACAUCC	12279	cucAAAucAAGGcAcAuccdTsdT	sense

2406-2425	10280	GGAUGUGCCUUGAUUUGAG	12280	GGAUGUGCCUUGAUUUGAGdTsdT	antis

2407-2426	10281	UCAAAUCAAGGCACAUCCU	12281	ucAAAucAAGGcAcAuccudTsdT	sense

2407-2426	10282	AGGAUGUGCCUUGAUUUGA	12282	AGGAUGUGCCUUGAUUUGAdTsdT	antis

2410-2429	10283	AAUCAAGGCACAUCCUUGG	12283	AAucAAGGcAcAuccuuGGdTsdT	sense

2410-2429	10284	CCAAGGAUGUGCCUUGAUU	12284	CcAAGGAUGUGCCUUGAUUdTsdT	antis

2411-2430	10285	AUCAAGGCACAUCCUUGGA	12285	AucAAGGcAcAuccuuGGAdTsdT	sense

2411-2430	10286	UCCAAGGAUGUGCCUUGAU	12286	UCcAAGGAUGUGCCUUGAUdTsdT	antis

2413-2432	10287	CAAGGCACAUCCUUGGACA	12287	cAAGGcAcAuccuuGGAcAdTsdT	sense

2413-2432	10288	UGUCCAAGGAUGUGCCUUG	12288	UGUCcAAGGAUGUGCCUUGdTsdT	antis

2415-2434	10289	AGGCACAUCCUUGGACAAA	12289	AGGcAcAuccuuGGAcAAAdTsdT	sense

2415-2434	10290	UUUGUCCAAGGAUGUGCCU	12290	UUUGUCcAAGGAUGUGCCUdTsdT	antis

2416-2435	10291	GGCACAUCCUUGGACAAAG	12291	GGcAcAuccuuGGAcAAAGdTsdT	sense

2416-2435	10292	CUUUGUCCAAGGAUGUGCC	12292	CUUUGUCcAAGGAUGUGCCdTsdT	antis

2417-2436	10293	GCACAUCCUUGGACAAAGG	12293	GcAcAuccuuGGAcAAAGGdTsdT	sense

2417-2436	10294	CCUUUGUCCAAGGAUGUGC	12294	CCUUUGUCcAAGGAUGUGCdTsdT	antis

2418-2437	10295	CACAUCCUUGGACAAAGGU	12295	cAcAuccuuGGAcAAAGGudTsdT	sense

2418-2437	10296	ACCUUUGUCCAAGGAUGUG	12296	ACCUUUGUCcAAGGAUGUGdTsdT	antis

2420-2439	10297	CAUCCUUGGACAAAGGUCU	12297	cAuccuuGGAcAAAGGucudTsdT	sense

2420-2439	10298	AGACCUUUGUCCAAGGAUG	12298	AGACCUUUGUCcAAGGAUGdTsdT	antis

2422-2441	10299	UCCUUGGACAAAGGUCUUC	12299	uccuuGGAcAAAGGucuucdTsdT	sense

2422-2441	10300	GAAGACCUUUGUCCAAGGA	12300	GAAGACCUUUGUCcAAGGAdTsdT	antis

2426-2445	10301	UGGACAAAGGUCUUCCGGC	12301	uGGAcAAAGGucuuccGGcdTsdT	sense

2426-2445	10302	GCCGGAAGACCUUUGUCCA	12302	GCCGGAAGACCUUUGUCcAdTsdT	antis

2430-2449	10303	CAAAGGUCUUCCGGCCCCG	12303	cAAAGGucuuccGGccccGdTsdT	sense

2430-2449	10304	CGGGGCCGGAAGACCUUUG	12304	CGGGGCCGGAAGACCUUUGdTsdT	antis

2439-2458	10305	UCCGGCCCCGAACUCCACC	12305	uccGGccccGAAcuccAccdTsdT	sense

2439-2458	10306	GGUGGAGUUCGGGGCCGGA	12306	GGUGGAGUUCGGGGCCGGAdTsdT	antis

2443-2462	10307	GCCCCGAACUCCACCAGAG	12307	GccccGAAcuccAccAGAGdTsdT	sense

2443-2462	10308	CUCUGGUGGAGUUCGGGGC	12308	CUCUGGUGGAGUUCGGGGCdTsdT	antis

2444-2463	10309	CCCCGAACUCCACCAGAGG	12309	ccccGAAcuccAccAGAGGdTsdT	sense

2444-2463	10310	CCUCUGGUGGAGUUCGGGG	12310	CCUCUGGUGGAGUUCGGGGdTsdT	antis

2446-2465	10311	CCGAACUCCACCAGAGGCA	12311	ccGAAcuccAccAGAGGcAdTsdT	sense

2446-2465	10312	UGCCUCUGGUGGAGUUCGG	12312	UGCCUCUGGUGGAGUUCGGdTsdT	antis

2447-2466	10313	CGAACUCCACCAGAGGCAA	12313	cGAAcuccAccAGAGGcAAdTsdT	sense

2447-2466	10314	UUGCCUCUGGUGGAGUUCG	12314	UUGCCUCUGGUGGAGUUCGdTsdT	antis

2448-2467	10315	GAACUCCACCAGAGGCAAU	12315	GAAcuccAccAGAGGcAAudTsdT	sense

2448-2467	10316	AUUGCCUCUGGUGGAGUUC	12316	AUUGCCUCUGGUGGAGUUCdTsdT	antis

2458-2477	10317	AGAGGCAAUUGCACUGUGC	12317	AGAGGcAAuuGcAcuGuGcdTsdT	sense

2458-2477	10318	GCACAGUGCAAUUGCCUCU	12318	GcAcAGUGcAAUUGCCUCUdTsdT	antis

2459-2478	10319	GAGGCAAUUGCACUGUGCA	12319	GAGGcAAuuGcAcuGuGcAdTsdT	sense

2459-2478	10320	UGCACAGUGCAAUUGCCUC	12320	UGcAcAGUGcAAUUGCCUCdTsdT	antis

2461-2480	10321	GGCAAUUGCACUGUGCAGC	12321	GGcAAuuGcAcuGuGcAGcdTsdT	sense

2461-2480	10322	GCUGCACAGUGCAAUUGCC	12322	GCUGcAcAGUGcAAUUGCCdTsdT	antis

2462-2481	10323	GCAAUUGCACUGUGCAGCC	12323	GcAAuuGcAcuGuGcAGccdTsdT	sense

2462-2481	10324	GGCUGCACAGUGCAAUUGC	12324	GGCUGcAcAGUGcAAUUGCdTsdT	antis

2464-2483	10325	AAUUGCACUGUGCAGCCGU	12325	AAuuGcAcuGuGcAGccGudTsdT	sense

2464-2483	10326	ACGGCUGCACAGUGCAAUU	12326	ACGGCUGcAcAGUGcAAUUdTsdT	antis

2465-2484	10327	AUUGCACUGUGCAGCCGUC	12327	AuuGcAcuGuGcAGccGucdTsdT	sense

2465-2484	10328	GACGGCUGCACAGUGCAAU	12328	GACGGCUGcAcAGUGcAAUdTsdT	antis

2471-2490	10329	CUGUGCAGCCGUCUGCUGG	12329	cuGuGcAGccGucuGcuGGdTsdT	sense

2471-2490	10330	CCAGCAGACGGCUGCACAG	12330	CcAGcAGACGGCUGcAcAGdTsdT	antis

2485-2504	10331	GCUGGAGUACACACCUACC	12331	GcuGGAGuAcAcAccuAccdTsdT	sense

2485-2504	10332	GGUAGGUGUGUACUCCAGC	12332	GGuAGGUGUGuACUCcAGCdTsdT	antis

2507-2526	10333	CGGCUAACACCACUGGAAG	12333	cGGcuAAcAccAcuGGAAGdTsdT	sense

2507-2526	10334	CUUCCAGUGGUGUUAGCCG	12334	CUUCcAGUGGUGUuAGCCGdTsdT	antis

2509-2528	10335	GCUAACACCACUGGAAGCU	12335	GcuAAcAccAcuGGAAGcudTsdT	sense

2509-2528	10336	AGCUUCCAGUGGUGUUAGC	12336	AGCUUCcAGUGGUGUuAGCdTsdT	antis

2510-2529	10337	CUAACACCACUGGAAGCUU	12337	cuAAcAccAcuGGAAGcuudTsdT	sense

2510-2529	10338	AAGCUUCCAGUGGUGUUAG	12338	AAGCUUCcAGUGGUGUuAGdTsdT	antis

2512-2531	10339	AACACCACUGGAAGCUUGU	12339	AAcAccAcuGGAAGcuuGudTsdT	sense

2512-2531	10340	ACAAGCUUCCAGUGGUGUU	12340	AcAAGCUUCcAGUGGUGUUdTsdT	antis

2513-2532	10341	ACACCACUGGAAGCUUGUG	12341	AcAccAcuGGAAGcuuGuGdTsdT	sense

2513-2532	10342	CACAAGCUUCCAGUGGUGU	12342	cAcAAGCUUCcAGUGGUGUdTsdT	antis

2514-2533	10343	CACCACUGGAAGCUUGUGC	12343	cAccAcuGGAAGcuuGuGcdTsdT	sense

2514-2533	10344	GCACAAGCUUCCAGUGGUG	12344	GcAcAAGCUUCcAGUGGUGdTsdT	antis

2515-2534	10345	ACCACUGGAAGCUUGUGCA	12345	AccAcuGGAAGcuuGuGcAdTsdT	sense

2515-2534	10346	UGCACAAGCUUCCAGUGGU	12346	UGcAcAAGCUUCcAGUGGUdTsdT	antis

2517-2536	10347	CACUGGAAGCUUGUGCACA	12347	cAcuGGAAGcuuGuGcAcAdTsdT	sense

2517-2536	10348	UGUGCACAAGCUUCCAGUG	12348	UGUGcAcAAGCUUCcAGUGdTsdT	antis

2519-2538	10349	CUGGAAGCUUGUGCACAUU	12349	cuGGAAGcuuGuGcAcAuudTsdT	sense

2519-2538	10350	AAUGUGCACAAGCUUCCAG	12350	AAUGUGcAcAAGCUUCcAGdTsdT	antis

2520-2539	10351	UGGAAGCUUGUGCACAUUC	12351	uGGAAGcuuGuGcAcAuucdTsdT	sense

2520-2539	10352	GAAUGUGCACAAGCUUCCA	12352	GAAUGUGcAcAAGCUUCcAdTsdT	antis

2521-2540	10353	GGAAGCUUGUGCACAUUCA	12353	GGAAGcuuGuGcAcAuucAdTsdT	sense

2521-2540	10354	UGAAUGUGCACAAGCUUCC	12354	UGAAUGUGcAcAAGCUUCCdTsdT	antis

2522-2541	10355	GAAGCUUGUGCACAUUCAU	12355	GAAGcuuGuGcAcAuucAudTsdT	sense

2522-2541	10356	AUGAAUGUGCACAAGCUUC	12356	AUGAAUGUGcAcAAGCUUCdTsdT	antis

2524-2543	10357	AGCUUGUGCACAUUCAUUU	12357	AGcuuGuGcAcAuucAuuudTsdT	sense

2524-2543	10358	AAAUGAAUGUGCACAAGCU	12358	AAAUGAAUGUGcAcAAGCUdTsdT	antis

1560-1579	10359	AGAGCUGCAAGCCAGUGCA	12359	AGAGcuGcAAGccAGuGcAdTsdT	sense

1560-1579	10360	UGCACUGGCUUGCAGCUCU	12360	UGcACUGGCUUGcAGCUCUdTsdT	antis

1561-1580	10361	GAGCUGCAAGCCAGUGCAG	12361	GAGcuGcAAGccAGuGcAGdTsdT	sense

1561-1580	10362	CUGCACUGGCUUGCAGCUC	12362	CUGcACUGGCUUGcAGCUCdTsdT	antis

1575-1594	10363	UGCAGCAGCCUUCAGCUUU	12363	uGcAGcAGccuucAGcuuudTsdT	sense

1575-1594	10364	AAAGCUGAAGGCUGCUGCA	12364	AAAGCUGAAGGCUGCUGcAdTsdT	antis

1611-1630	10365	GCAGAGAUAAAGAUGGCAG	12365	GcAGAGAuAAAGAuGGcAGdTsdT	sense

1611-1630	10366	CUGCCAUCUUUAUCUCUGC	12366	CUGCcAUCUUuAUCUCUGCdTsdT	antis

1661-1680	10367	CAGGGUCCUGACAGGCCAC	12367	cAGGGuccuGAcAGGccAcdTsdT	sense

1661-1680	10368	GUGGCCUGUCAGGACCCUG	12368	GUGGCCUGUcAGGACCCUGdTsdT	antis

1779-1798	10369	AGAAAGUUCUACAGGACAA	12369	AGAAAGuucuAcAGGAcAAdTsdT	sense

1779-1798	10370	UUGUCCUGUAGAACUUUCU	12370	UUGUCCUGuAGAACUUUCUdTsdT	antis

1917-1936	10371	UGCUGGACUAUGUUCCGGA	12371	uGcuGGAcuAuGuuccGGAdTsdT	sense

1917-1936	10372	UCCGGAACAUAGUCCAGCA	12372	UCCGGAAcAuAGUCcAGcAdTsdT	antis

2012-2031	10373	UAUCAGCUGUUCAGAAGUC	12373	uAucAGcuGuucAGAAGucdTsdT	sense

2012-2031	10374	GACUUCUGAACAGCUGAUA	12374	GACUUCUGAAcAGCUGAuAdTsdT	antis

2042-2061	10375	CAUUCCUUUGGAAUCUGCC	12375	cAuuccuuuGGAAucuGccdTsdT	sense

2042-2061	10376	GGCAGAUUCCAAAGGAAUG	12376	GGcAGAUUCcAAAGGAAUGdTsdT	antis

2053-2072	10377	AAUCUGCCAUCGAGACAUU	12377	AAucuGccAucGAGAcAuudTsdT	sense

2053-2072	10378	AAUGUCUCGAUGGCAGAUU	12378	AAUGUCUCGAUGGcAGAUUdTsdT	antis

2066-2085	10379	GACAUUAAACCACAGAACC	12379	GAcAuuAAAccAcAGAAccdTsdT	sense

2066-2085	10380	GGUUCUGUGGUUUAAUGUC	12380	GGUUCUGUGGUUuAAUGUCdTsdT	antis

2149-2168	10381	CCGAGGAGAGCCCAAUGUU	12381	ccGAGGAGAGcccAAuGuudTsdT	sense

2149-2168	10382	AACAUUGGGCUCUCCUCGG	12382	AAcAUUGGGCUCUCCUCGGdTsdT	antis

2248-2267	10383	GUCUGCAGGCUGUGUGUUG	12383	GucuGcAGGcuGuGuGuuGdTsdT	sense

2248-2267	10384	CAACACACAGCCUGCAGAC	12384	cAAcAcAcAGCCUGcAGACdTsdT	antis

2302-2321	10385	GGACAGUGGUGUGGAUCAG	12385	GGAcAGuGGuGuGGAucAGdTsdT	sense

2302-2321	10386	CUGAUCCACACCACUGUCC	12386	CUGAUCcAcACcACUGUCCdTsdT	antis

2330-2349	10387	AUAAUAAAGGUCCUAGGAA	12387	AuAAuAAAGGuccuAGGAAdTsdT	sense

2330-2349	10388	UUCCUAGGACCUUUAUUAU	12388	UUCCuAGGACCUUuAUuAUdTsdT	antis

2362-2381	10389	GCAAAUUAGAGAAAUGAAC	12389	GcAAAuuAGAGAAAuGAAcdTsdT	sense

2362-2381	10390	GUUCAUUUCUCUAAUUUGC	12390	GUUcAUUUCUCuAAUUUGCdTsdT	antis

2366-2385	10391	AUUAGAGAAAUGAACCCAA	12391	AuuAGAGAAAuGAAcccAAdTsdT	sense

2366-2385	10392	UUGGGUUCAUUUCUCUAAU	12392	UUGGGUUcAUUUCUCuAAUdTsdT	antis

2378-2397	10393	AACCCAAAUUAUACAGAAU	12393	AAcccAAAuuAuAcAGAAudTsdT	sense

2378-2397	10394	AUUCUGUAUAAUUUGGGUU	12394	AUUCUGuAuAAUUUGGGUUdTsdT	antis

2432-2451	10395	AAGGUCUUCCGGCCCCGAA	12395	AAGGucuuccGGccccGAAdTsdT	sense

2432-2451	10396	UUCGGGGCCGGAAGACCUU	12396	UUCGGGGCCGGAAGACCUUdTsdT	antis

2441-2460	10397	CGGCCCCGAACUCCACCAG	12397	cGGccccGAAcuccAccAGdTsdT	sense

2441-2460	10398	CUGGUGGAGUUCGGGGCCG	12398	CUGGUGGAGUUCGGGGCCGdTsdT	antis

2456-2475	10399	CCAGAGGCAAUUGCACUGU	12399	ccAGAGGcAAuuGcAcuGudTsdT	sense

2456-2475	10400	ACAGUGCAAUUGCCUCUGG	12400	AcAGUGcAAUUGCCUCUGGdTsdT	antis

2472-2491	10401	UGUGCAGCCGUCUGCUGGA	12401	uGuGcAGccGucuGcuGGAdTsdT	sense

2472-2491	10402	UCCAGCAGACGGCUGCACA	12402	UCcAGcAGACGGCUGcAcAdTsdT	antis

1538-1557	10403	CCGAGAACCACCUCCUUUG	12403	ccGAGAAccAccuccuuuGdTsdT	sense

1538-1557	10404	CAAAGGAGGUGGUUCUCGG	12404	cAAAGGAGGUGGUUCUCGGdTsdT	antis

1539-1558	10405	CGAGAACCACCUCCUUUGC	12405	cGAGAAccAccuccuuuGcdTsdT	sense

1539-1558	10406	GCAAAGGAGGUGGUUCUCG	12406	GcAAAGGAGGUGGUUCUCGdTsdT	antis

1547-1566	10407	ACCUCCUUUGCGGAGAGCU	12407	AccuccuuuGcGGAGAGcudTsdT	sense

1547-1566	10408	AGCUCUCCGCAAAGGAGGU	12408	AGCUCUCCGcAAAGGAGGUdTsdT	antis

1551-1570	10409	CCUUUGCGGAGAGCUGCAA	12409	ccuuuGcGGAGAGcuGcAAdTsdT	sense

1551-1570	10410	UUGCAGCUCUCCGCAAAGG	12410	UUGcAGCUCUCCGcAAAGGdTsdT	antis

1558-1577	10411	GGAGAGCUGCAAGCCAGUG	12411	GGAGAGcuGcAAGccAGuGdTsdT	sense

1558-1577	10412	CACUGGCUUGCAGCUCUCC	12412	cACUGGCUUGcAGCUCUCCdTsdT	antis

1573-1592	10413	AGUGCAGCAGCCUUCAGCU	12413	AGuGcAGcAGccuucAGcudTsdT	sense

1573-1592	10414	AGCUGAAGGCUGCUGCACU	12414	AGCUGAAGGCUGCUGcACUdTsdT	antis

1574-1593	10415	GUGCAGCAGCCUUCAGCUU	12415	GuGcAGcAGccuucAGcuudTsdT	sense

1574-1593	10416	AAGCUGAAGGCUGCUGCAC	12416	AAGCUGAAGGCUGCUGcACdTsdT	antis

1584-1603	10417	CUUCAGCUUUUGGUAGCAU	12417	cuucAGcuuuuGGuAGcAudTsdT	sense

1584-1603	10418	AUGCUACCAAAAGCUGAAG	12418	AUGCuACcAAAAGCUGAAGdTsdT	antis

1594-1613	10419	UGGUAGCAUGAAAGUUAGC	12419	uGGuAGcAuGAAAGuuAGcdTsdT	sense

1594-1613	10420	GCUAACUUUCAUGCUACCA	12420	GCuAACUUUcAUGCuACcAdTsdT	antis

1599-1618	10421	GCAUGAAAGUUAGCAGAGA	12421	GcAuGAAAGuuAGcAGAGAdTsdT	sense

1599-1618	10422	UCUCUGCUAACUUUCAUGC	12422	UCUCUGCuAACUUUcAUGCdTsdT	antis

1600-1619	10423	CAUGAAAGUUAGCAGAGAU	12423	cAuGAAAGuuAGcAGAGAudTsdT	sense

1600-1619	10424	AUCUCUGCUAACUUUCAUG	12424	AUCUCUGCuAACUUUcAUGdTsdT	antis

1613-1632	10425	AGAGAUAAAGAUGGCAGCA	12425	AGAGAuAAAGAuGGcAGcAdTsdT	sense

1613-1632	10426	UGCUGCCAUCUUUAUCUCU	12426	UGCUGCcAUCUUuAUCUCUdTsdT	antis

1614-1633	10427	GAGAUAAAGAUGGCAGCAA	12427	GAGAuAAAGAuGGcAGcAAdTsdT	sense

1614-1633	10428	UUGCUGCCAUCUUUAUCUC	12428	UUGCUGCcAUCUUuAUCUCdTsdT	antis

1630-1649	10429	CAAGGUAACCACAGUAGUG	12429	cAAGGuAAccAcAGuAGuGdTsdT	sense

1630-1649	10430	CACUACUGUGGUUACCUUG	12430	cACuACUGUGGUuACCUUGdTsdT	antis

1650-1669	10431	CAACUCCUGGCCAGGGUCC	12431	cAAcuccuGGccAGGGuccdTsdT	sense

1650-1669	10432	GGACCCUGGCCAGGAGUUG	12432	GGACCCUGGCcAGGAGUUGdTsdT	antis

1652-1671	10433	ACUCCUGGCCAGGGUCCUG	12433	AcuccuGGccAGGGuccuGdTsdT	sense

1652-1671	10434	CAGGACCCUGGCCAGGAGU	12434	cAGGACCCUGGCcAGGAGUdTsdT	antis

1653-1672	10435	CUCCUGGCCAGGGUCCUGA	12435	cuccuGGccAGGGuccuGAdTsdT	sense

1653-1672	10436	UCAGGACCCUGGCCAGGAG	12436	UcAGGACCCUGGCcAGGAGdTsdT	antis

1654-1673	10437	UCCUGGCCAGGGUCCUGAC	12437	uccuGGccAGGGuccuGAcdTsdT	sense

1654-1673	10438	GUCAGGACCCUGGCCAGGA	12438	GUcAGGACCCUGGCcAGGAdTsdT	antis

1665-1684	10439	GUCCUGACAGGCCACAGGA	12439	GuccuGAcAGGccAcAGGAdTsdT	sense

1665-1684	10440	UCCUGUGGCCUGUCAGGAC	12440	UCCUGUGGCCUGUcAGGACdTsdT	antis

1673-1692	10441	AGGCCACAGGAAGUCAGUU	12441	AGGccAcAGGAAGucAGuudTsdT	sense

1673-1692	10442	AACUGACUUCCUGUGGCCU	12442	AACUGACUUCCUGUGGCCUdTsdT	antis

1688-1707	10443	AGUUAUACAGACACGAAAG	12443	AGuuAuAcAGAcAcGAAAGdTsdT	sense

1688-1707	10444	CUUUCGUGUCUGUAUAACU	12444	CUUUCGUGUCUGuAuAACUdTsdT	antis

1743-1762	10445	CCAAACUUUGUGAUUCUGG	12445	ccAAAcuuuGuGAuucuGGdTsdT	sense

1743-1762	10446	CCAGAAUCACAAAGUUUGG	12446	CcAGAAUcAcAAAGUUUGGdTsdT	antis

1744-1763	10447	CAAACUUUGUGAUUCUGGA	12447	cAAAcuuuGuGAuucuGGAdTsdT	sense

1744-1763	10448	UCCAGAAUCACAAAGUUUG	12448	UCcAGAAUcAcAAAGUUUGdTsdT	antis

1745-1764	10449	AAACUUUGUGAUUCUGGAG	12449	AAAcuuuGuGAuucuGGAGdTsdT	sense

1745-1764	10450	CUCCAGAAUCACAAAGUUU	12450	CUCcAGAAUcAcAAAGUUUdTsdT	antis

1746-1765	10451	AACUUUGUGAUUCUGGAGA	12451	AAcuuuGuGAuucuGGAGAdTsdT	sense

1746-1765	10452	UCUCCAGAAUCACAAAGUU	12452	UCUCcAGAAUcAcAAAGUUdTsdT	antis

1780-1799	10453	GAAAGUUCUACAGGACAAG	12453	GAAAGuucuAcAGGAcAAGdTsdT	sense

1780-1799	10454	CUUGUCCUGUAGAACUUUC	12454	CUUGUCCUGuAGAACUUUCdTsdT	antis

1781-1800	10455	AAAGUUCUACAGGACAAGC	12455	AAAGuucuAcAGGAcAAGcdTsdT	sense

1781-1800	10456	GCUUGUCCUGUAGAACUUU	12456	GCUUGUCCUGuAGAACUUUdTsdT	antis

1782-1801	10457	AAGUUCUACAGGACAAGCG	12457	AAGuucuAcAGGAcAAGcGdTsdT	sense

1782-1801	10458	CGCUUGUCCUGUAGAACUU	12458	CGCUUGUCCUGuAGAACUUdTsdT	antis

1809-1828	10459	ACCGAGAGCUCCAGAUCAU	12459	AccGAGAGcuccAGAucAudTsdT	sense

1809-1828	10460	AUGAUCUGGAGCUCUCGGU	12460	AUGAUCUGGAGCUCUCGGUdTsdT	antis

1880-1899	10461	AGUGGUGAGAAGAAAGAUG	12461	AGuGGuGAGAAGAAAGAuGdTsdT	sense

1880-1899	10462	CAUCUUUCUUCUCACCACU	12462	cAUCUUUCUUCUcACcACUdTsdT	antis

1885-1904	10463	UGAGAAGAAAGAUGAGGUC	12463	uGAGAAGAAAGAuGAGGucdTsdT	sense

1885-1904	10464	GACCUCAUCUUUCUUCUCA	12464	GACCUcAUCUUUCUUCUcAdTsdT	antis

1889-1908	10465	AAGAAAGAUGAGGUCUACC	12465	AAGAAAGAuGAGGucuAccdTsdT	sense

1889-1908	10466	GGUAGACCUCAUCUUUCUU	12466	GGuAGACCUcAUCUUUCUUdTsdT	antis

2043-2062	10467	AUUCCUUUGGAAUCUGCCA	12467	AuuccuuuGGAAucuGccAdTsdT	sense

2043-2062	10468	UGGCAGAUUCCAAAGGAAU	12468	UGGcAGAUUCcAAAGGAAUdTsdT	antis

2050-2069	10469	UGGAAUCUGCCAUCGAGAC	12469	uGGAAucuGccAucGAGAcdTsdT	sense

2050-2069	10470	GUCUCGAUGGCAGAUUCCA	12470	GUCUCGAUGGcAGAUUCcAdTsdT	antis

2092-2111	10471	GGAUCCUGAUACAGCUGUA	12471	GGAuccuGAuAcAGcuGuAdTsdT	sense

2092-2111	10472	UACAGCUGUAUCAGGAUCC	12472	uAcAGCUGuAUcAGGAUCCdTsdT	antis

2116-2135	10473	ACUCUGUGACUUUGGAAGU	12473	AcucuGuGAcuuuGGAAGudTsdT	sense

2116-2135	10474	ACUUCCAAAGUCACAGAGU	12474	ACUUCcAAAGUcAcAGAGUdTsdT	antis

2143-2162	10475	GCUGGUCCGAGGAGAGCCC	12475	GcuGGuccGAGGAGAGcccdTsdT	sense

2143-2162	10476	GGGCUCUCCUCGGACCAGC	12476	GGGCUCUCCUCGGACcAGCdTsdT	antis

2159-2178	10477	CCCAAUGUUUCAUAUAUCU	12477	cccAAuGuuucAuAuAucudTsdT	sense

2159-2178	10478	AGAUAUAUGAAACAUUGGG	12478	AGAuAuAUGAAAcAUUGGGdTsdT	antis

2163-2182	10479	AUGUUUCAUAUAUCUGUUC	12479	AuGuuucAuAuAucuGuucdTsdT	sense

2163-2182	10480	GAACAGAUAUAUGAAACAU	12480	GAAcAGAuAuAUGAAAcAUdTsdT	antis

2207-2226	10481	AUCUUUGGAGCCACUGAUU	12481	AucuuuGGAGccAcuGAuudTsdT	sense

2207-2226	10482	AAUCAGUGGCUCCAAAGAU	12482	AAUcAGUGGCUCcAAAGAUdTsdT	antis

2247-2266	10483	GGUCUGCAGGCUGUGUGUU	12483	GGucuGcAGGcuGuGuGuudTsdT	sense

2247-2266	10484	AACACACAGCCUGCAGACC	12484	AAcAcAcAGCCUGcAGACCdTsdT	antis

2251-2270	10485	UGCAGGCUGUGUGUUGGCU	12485	uGcAGGcuGuGuGuuGGcudTsdT	sense

2251-2270	10486	AGCCAACACACAGCCUGCA	12486	AGCcAAcAcAcAGCCUGcAdTsdT	antis

2261-2280	10487	GUGUUGGCUGAAUUGUUGC	12487	GuGuuGGcuGAAuuGuuGcdTsdT	sense

2261-2280	10488	GCAACAAUUCAGCCAACAC	12488	GcAAcAAUUcAGCcAAcACdTsdT	antis

2298-2317	10489	CUGGGGACAGUGGUGUGGA	12489	cuGGGGAcAGuGGuGuGGAdTsdT	sense

2298-2317	10490	UCCACACCACUGUCCCCAG	12490	UCcAcACcACUGUCCCcAGdTsdT	antis

2300-2319	10491	GGGGACAGUGGUGUGGAUC	12491	GGGGAcAGuGGuGuGGAucdTsdT	sense

2300-2319	10492	GAUCCACACCACUGUCCCC	12492	GAUCcAcACcACUGUCCCCdTsdT	antis

2301-2320	10493	GGGACAGUGGUGUGGAUCA	12493	GGGAcAGuGGuGuGGAucAdTsdT	sense

2301-2320	10494	UGAUCCACACCACUGUCCC	12494	UGAUCcAcACcACUGUCCCdTsdT	antis

2319-2338	10495	AGUUGGUGGAAAUAAUAAA	12495	AGuuGGuGGAAAuAAuAAAdTsdT	sense

2319-2338	10496	UUUAUUAUUUCCACCAACU	12496	UUuAUuAUUUCcACcAACUdTsdT	antis

2323-2342	10497	GGUGGAAAUAAUAAAGGUC	12497	GGuGGAAAuAAuAAAGGucdTsdT	sense

2323-2342	10498	GACCUUUAUUAUUUCCACC	12498	GACCUUuAUuAUUUCcACCdTsdT	antis

2325-2344	10499	UGGAAAUAAUAAAGGUCCU	12499	uGGAAAuAAuAAAGGuccudTsdT	sense

2325-2344	10500	AGGACCUUUAUUAUUUCCA	12500	AGGACCUUuAUuAUUUCcAdTsdT	antis

2363-2382	10501	CAAAUUAGAGAAAUGAACC	12501	cAAAuuAGAGAAAuGAAccdTsdT	sense

2363-2382	10502	GGUUCAUUUCUCUAAUUUG	12502	GGUUcAUUUCUCuAAUUUGdTsdT	antis

2376-2395	10503	UGAACCCAAAUUAUACAGA	12503	uGAAcccAAAuuAuAcAGAdTsdT	sense

2376-2395	10504	UCUGUAUAAUUUGGGUUCA	12504	UCUGuAuAAUUUGGGUUcAdTsdT	antis

2377-2396	10505	GAACCCAAAUUAUACAGAA	12505	GAAcccAAAuuAuAcAGAAdTsdT	sense

2377-2396	10506	UUCUGUAUAAUUUGGGUUC	12506	UUCUGuAuAAUUUGGGUUCdTsdT	antis

2383-2402	10507	AAAUUAUACAGAAUUCAAA	12507	AAAuuAuAcAGAAuucAAAdTsdT	sense

2383-2402	10508	UUUGAAUUCUGUAUAAUUU	12508	UUUGAAUUCUGuAuAAUUUdTsdT	antis

2391-2410	10509	CAGAAUUCAAAUUCCCUCA	12509	cAGAAuucAAAuucccucAdTsdT	sense

2391-2410	10510	UGAGGGAAUUUGAAUUCUG	12510	UGAGGGAAUUUGAAUUCUGdTsdT	antis

2394-2413	10511	AAUUCAAAUUCCCUCAAAU	12511	AAuucAAAuucccucAAAudTsdT	sense

2394-2413	10512	AUUUGAGGGAAUUUGAAUU	12512	AUUUGAGGGAAUUUGAAUUdTsdT	antis

2436-2455	10513	UCUUCCGGCCCCGAACUCC	12513	ucuuccGGccccGAAcuccdTsdT	sense

2436-2455	10514	GGAGUUCGGGGCCGGAAGA	12514	GGAGUUCGGGGCCGGAAGAdTsdT	antis

2442-2461	10515	GGCCCCGAACUCCACCAGA	12515	GGccccGAAcuccAccAGAdTsdT	sense

2442-2461	10516	UCUGGUGGAGUUCGGGGCC	12516	UCUGGUGGAGUUCGGGGCCdTsdT	antis

2449-2468	10517	AACUCCACCAGAGGCAAUU	12517	AAcuccAccAGAGGcAAuudTsdT	sense

2449-2468	10518	AAUUGCCUCUGGUGGAGUU	12518	AAUUGCCUCUGGUGGAGUUdTsdT	antis

2450-2469	10519	ACUCCACCAGAGGCAAUUG	12519	AcuccAccAGAGGcAAuuGdTsdT	sense

2450-2469	10520	CAAUUGCCUCUGGUGGAGU	12520	cAAUUGCCUCUGGUGGAGUdTsdT	antis

2457-2476	10521	CAGAGGCAAUUGCACUGUG	12521	cAGAGGcAAuuGcAcuGuGdTsdT	sense

2457-2476	10522	CACAGUGCAAUUGCCUCUG	12522	cAcAGUGcAAUUGCCUCUGdTsdT	antis

2470-2489	10523	ACUGUGCAGCCGUCUGCUG	12523	AcuGuGcAGccGucuGcuGdTsdT	sense

2470-2489	10524	CAGCAGACGGCUGCACAGU	12524	cAGcAGACGGCUGcAcAGUdTsdT	antis

2473-2492	10525	GUGCAGCCGUCUGCUGGAG	12525	GuGcAGccGucuGcuGGAGdTsdT	sense

2473-2492	10526	CUCCAGCAGACGGCUGCAC	12526	CUCcAGcAGACGGCUGcACdTsdT	antis

2475-2494	10527	GCAGCCGUCUGCUGGAGUA	12527	GcAGccGucuGcuGGAGuAdTsdT	sense

2475-2494	10528	UACUCCAGCAGACGGCUGC	12528	uACUCcAGcAGACGGCUGCdTsdT	antis

1612-1631	10529	CAGAGAUAAAGAUGGCAGC	12529	cAGAGAuAAAGAuGGcAGcdTsdT	sense

1612-1631	10530	GCUGCCAUCUUUAUCUCUG	12530	GCUGCcAUCUUuAUCUCUGdTsdT	antis

1804-1823	10531	UAAGAACCGAGAGCUCCAG	12531	uAAGAAccGAGAGcuccAGdTsdT	sense

1804-1823	10532	CUGGAGCUCUCGGUUCUUA	12532	CUGGAGCUCUCGGUUCUuAdTsdT	antis

1805-1824	10533	AAGAACCGAGAGCUCCAGA	12533	AAGAAccGAGAGcuccAGAdTsdT	sense

1805-1824	10534	UCUGGAGCUCUCGGUUCUU	12534	UCUGGAGCUCUCGGUUCUUdTsdT	antis

1888-1907	10535	GAAGAAAGAUGAGGUCUAC	12535	GAAGAAAGAuGAGGucuAcdTsdT	sense

1888-1907	10536	GUAGACCUCAUCUUUCUUC	12536	GuAGACCUcAUCUUUCUUCdTsdT	antis

2165-2184	10537	GUUUCAUAUAUCUGUUCUC	12537	GuuucAuAuAucuGuucucdTsdT	sense

2165-2184	10538	GAGAACAGAUAUAUGAAAC	12538	GAGAAcAGAuAuAUGAAACdTsdT	antis

2332-2351	10539	AAUAAAGGUCCUAGGAACA	12539	AAuAAAGGuccuAGGAAcAdTsdT	sense

2332-2351	10540	UGUUCCUAGGACCUUUAUU	12540	UGUUCCuAGGACCUUuAUUdTsdT	antis

2518-2537	10541	ACUGGAAGCUUGUGCACAU	12541	AcuGGAAGcuuGuGcAcAudTsdT	sense

2518-2537	10542	AUGUGCACAAGCUUCCAGU	12542	AUGUGcAcAAGCUUCcAGUdTsdT	antis

1565-1584	10543	UGCAAGCCAGUGCAGCAGC	12543	uGcAAGccAGuGcAGcAGcdTsdT	sense

1565-1584	10544	GCUGCUGCACUGGCUUGCA	12544	GCUGCUGcACUGGCUUGcAdTsdT	antis

1569-1588	10545	AGCCAGUGCAGCAGCCUUC	12545	AGccAGuGcAGcAGccuucdTsdT	sense

1569-1588	10546	GAAGGCUGCUGCACUGGCU	12546	GAAGGCUGCUGcACUGGCUdTsdT	antis

1631-1650	10547	AAGGUAACCACAGUAGUGG	12547	AAGGuAAccAcAGuAGuGGdTsdT	sense

1631-1650	10548	CCACUACUGUGGUUACCUU	12548	CcACuACUGUGGUuACCUUdTsdT	antis

1659-1678	10549	GCCAGGGUCCUGACAGGCC	12549	GccAGGGuccuGAcAGGccdTsdT	sense

1659-1678	10550	GGCCUGUCAGGACCCUGGC	12550	GGCCUGUcAGGACCCUGGCdTsdT	antis

1711-1730	10551	UGGAAAUGGAUCAUUUGGU	12551	uGGAAAuGGAucAuuuGGudTsdT	sense

1711-1730	10552	ACCAAAUGAUCCAUUUCCA	12552	ACcAAAUGAUCcAUUUCcAdTsdT	antis

1756-1775	10553	UUCUGGAGAACUGGUUGCC	12553	uucuGGAGAAcuGGuuGccdTsdT	sense

1756-1775	10554	GGCAACCAGUUCUCCAGAA	12554	GGcAACcAGUUCUCcAGAAdTsdT	antis

1761-1780	10555	GAGAACUGGUUGCCAUCAA	12555	GAGAAcuGGuuGccAucAAdTsdT	sense

1761-1780	10556	UUGAUGGCAACCAGUUCUC	12556	UUGAUGGcAACcAGUUCUCdTsdT	antis

1762-1781	10557	AGAACUGGUUGCCAUCAAG	12557	AGAAcuGGuuGccAucAAGdTsdT	sense

1762-1781	10558	CUUGAUGGCAACCAGUUCU	12558	CUUGAUGGcAACcAGUUCUdTsdT	antis

1997-2016	10559	GUCAAGUUGUAUAUGUAUC	12559	GucAAGuuGuAuAuGuAucdTsdT	sense

1997-2016	10560	GAUACAUAUACAACUUGAC	12560	GAuAcAuAuAcAACUUGACdTsdT	antis

2040-2059	10561	UCCAUUCCUUUGGAAUCUG	12561	uccAuuccuuuGGAAucuGdTsdT	sense

2040-2059	10562	CAGAUUCCAAAGGAAUGGA	12562	cAGAUUCcAAAGGAAUGGAdTsdT	antis

2133-2152	10563	GUGCAAAGCAGCUGGUCCG	12563	GuGcAAAGcAGcuGGuccGdTsdT	sense

2133-2152	10564	CGGACCAGCUGCUUUGCAC	12564	CGGACcAGCUGCUUUGcACdTsdT	antis

2186-2205	10565	UACUACAGGGCACCAGAGU	12565	uAcuAcAGGGcAccAGAGudTsdT	sense

2186-2205	10566	ACUCUGGUGCCCUGUAGUA	12566	ACUCUGGUGCCCUGuAGuAdTsdT	antis

2250-2269	10567	CUGCAGGCUGUGUGUUGGC	12567	cuGcAGGcuGuGuGuuGGcdTsdT	sense

2250-2269	10568	GCCAACACACAGCCUGCAG	12568	GCcAAcAcAcAGCCUGcAGdTsdT	antis

2466-2485	10569	UUGCACUGUGCAGCCGUCU	12569	uuGcAcuGuGcAGccGucudTsdT	sense

2466-2485	10570	AGACGGCUGCACAGUGCAA	12570	AGACGGCUGcAcAGUGcAAdTsdT	antis

2523-2542	10571	AAGCUUGUGCACAUUCAUU	12571	AAGcuuGuGcAcAuucAuudTsdT	sense

2523-2542	10572	AAUGAAUGUGCACAAGCUU	12572	AAUGAAUGUGcAcAAGCUUdTsdT	antis

1548-1567	10573	CCUCCUUUGCGGAGAGCUG	12573	ccuccuuuGcGGAGAGcuGdTsdT	sense

1548-1567	10574	CAGCUCUCCGCAAAGGAGG	12574	cAGCUCUCCGcAAAGGAGGdTsdT	antis

1566-1585	10575	GCAAGCCAGUGCAGCAGCC	12575	GcAAGccAGuGcAGcAGccdTsdT	sense

1566-1585	10576	GGCUGCUGCACUGGCUUGC	12576	GGCUGCUGcACUGGCUUGCdTsdT	antis

1656-1675	10577	CUGGCCAGGGUCCUGACAG	12577	cuGGccAGGGuccuGAcAGdTsdT	sense

1656-1675	10578	CUGUCAGGACCCUGGCCAG	12578	CUGUcAGGACCCUGGCcAGdTsdT	antis

1763-1782	10579	GAACUGGUUGCCAUCAAGA	12579	GAAcuGGuuGccAucAAGAdTsdT	sense

1763-1782	10580	UCUUGAUGGCAACCAGUUC	12580	UCUUGAUGGcAACcAGUUCdTsdT	antis

2185-2204	10581	GUACUACAGGGCACCAGAG	12581	GuAcuAcAGGGcAccAGAGdTsdT	sense

2185-2204	10582	CUCUGGUGCCCUGUAGUAC	12582	CUCUGGUGCCCUGuAGuACdTsdT	antis

2212-2231	10583	UGGAGCCACUGAUUACACG	12583	uGGAGccAcuGAuuAcAcGdTsdT	sense

2212-2231	10584	CGUGUAAUCAGUGGCUCCA	12584	CGUGuAAUcAGUGGCUCcAdTsdT	antis

2265-2284	10585	UGGCUGAAUUGUUGCUAGG	12585	uGGcuGAAuuGuuGcuAGGdTsdT	sense

2265-2284	10586	CCUAGCAACAAUUCAGCCA	12586	CCuAGcAAcAAUUcAGCcAdTsdT	antis

2326-2345	10587	GGAAAUAAUAAAGGUCCUA	12587	GGAAAuAAuAAAGGuccuAdTsdT	sense

2326-2345	10588	UAGGACCUUUAUUAUUUCC	12588	uAGGACCUUuAUuAUUUCCdTsdT	antis

2425-2444	10589	UUGGACAAAGGUCUUCCGG	12589	uuGGAcAAAGGucuuccGGdTsdT	sense

2425-2444	10590	CCGGAAGACCUUUGUCCAA	12590	CCGGAAGACCUUUGUCcAAdTsdT	antis

1962-1981	10591	AUAGUCGAGCCAAGCAGAC	12591	AuAGucGAGccAAGcAGAcdTsdT	sense

1962-1981	10592	GUCUGCUUGGCUCGACUAU	12592	GUCUGCUUGGCUCGACuAUdTsdT	antis

1803-1822	10593	UUAAGAACCGAGAGCUCCA	12593	uuAAGAAccGAGAGcuccAdTsdT	sense

1803-1822	10594	UGGAGCUCUCGGUUCUUAA	12594	UGGAGCUCUCGGUUCUuAAdTsdT	antis

1808-1827	10595	AACCGAGAGCUCCAGAUCA	12595	AAccGAGAGcuccAGAucAdTsdT	sense

1808-1827	10596	UGAUCUGGAGCUCUCGGUU	12596	UGAUCUGGAGCUCUCGGUUdTsdT	antis

1603-1622	10597	GAAAGUUAGCAGAGAUAAA	12597	GAAAGuuAGcAGAGAuAAAdTsdT	sense

1603-1622	10598	UUUAUCUCUGCUAACUUUC	12598	UUuAUCUCUGCuAACUUUCdTsdT	antis

1640-1659	10599	ACAGUAGUGGCAACUCCUG	12599	AcAGuAGuGGcAAcuccuGdTsdT	sense

1640-1659	10600	CAGGAGUUGCCACUACUGU	12600	cAGGAGUUGCcACuACUGUdTsdT	antis

1718-1737	10601	GGAUCAUUUGGUGUGGUAU	12601	GGAucAuuuGGuGuGGuAudTsdT	sense

1718-1737	10602	AUACCACACCAAAUGAUCC	12602	AuACcAcACcAAAUGAUCCdTsdT	antis

1807-1826	10603	GAACCGAGAGCUCCAGAUC	12603	GAAccGAGAGcuccAGAucdTsdT	sense

1807-1826	10604	GAUCUGGAGCUCUCGGUUC	12604	GAUCUGGAGCUCUCGGUUCdTsdT	antis

1904-1923	10605	UACCUUAACCUGGUGCUGG	12605	uAccuuAAccuGGuGcuGGdTsdT	sense

1904-1923	10606	CCAGCACCAGGUUAAGGUA	12606	CcAGcACcAGGUuAAGGuAdTsdT	antis

1905-1924	10607	ACCUUAACCUGGUGCUGGA	12607	AccuuAAccuGGuGcuGGAdTsdT	sense

1905-1924	10608	UCCAGCACCAGGUUAAGGU	12608	UCcAGcACcAGGUuAAGGUdTsdT	antis

1906-1925	10609	CCUUAACCUGGUGCUGGAC	12609	ccuuAAccuGGuGcuGGAcdTsdT	sense

1906-1925	10610	GUCCAGCACCAGGUUAAGG	12610	GUCcAGcACcAGGUuAAGGdTsdT	antis

2015-2034	10611	CAGCUGUUCAGAAGUCUAG	12611	cAGcuGuucAGAAGucuAGdTsdT	sense

2015-2034	10612	CUAGACUUCUGAACAGCUG	12612	CuAGACUUCUGAAcAGCUGdTsdT	antis

2057-2076	10613	UGCCAUCGAGACAUUAAAC	12613	uGccAucGAGAcAuuAAAcdTsdT	sense

2057-2076	10614	GUUUAAUGUCUCGAUGGCA	12614	GUUuAAUGUCUCGAUGGcAdTsdT	antis

2109-2128	10615	UAUUAAAACUCUGUGACUU	12615	uAuuAAAAcucuGuGAcuudTsdT	sense

2109-2128	10616	AAGUCACAGAGUUUUAAUA	12616	AAGUcAcAGAGUUUuAAuAdTsdT	antis

2126-2145	10617	UUUGGAAGUGCAAAGCAGC	12617	uuuGGAAGuGcAAAGcAGcdTsdT	sense

2126-2145	10618	GCUGCUUUGCACUUCCAAA	12618	GCUGCUUUGcACUUCcAAAdTsdT	antis

2129-2148	10619	GGAAGUGCAAAGCAGCUGG	12619	GGAAGuGcAAAGcAGcuGGdTsdT	sense

2129-2148	10620	CCAGCUGCUUUGCACUUCC	12620	CcAGCUGCUUUGcACUUCCdTsdT	antis

2312-2331	10621	GUGGAUCAGUUGGUGGAAA	12621	GuGGAucAGuuGGuGGAAAdTsdT	sense

2312-2331	10622	UUUCCACCAACUGAUCCAC	12622	UUUCcACcAACUGAUCcACdTsdT	antis

2313-2332	10623	UGGAUCAGUUGGUGGAAAU	12623	uGGAucAGuuGGuGGAAAudTsdT	sense

2313-2332	10624	AUUUCCACCAACUGAUCCA	12624	AUUUCcACcAACUGAUCcAdTsdT	antis

2347-2366	10625	AACACCAACAAGGGAGCAA	12625	AAcAccAAcAAGGGAGcAAdTsdT	sense

2347-2366	10626	UUGCUCCCUUGUUGGUGUU	12626	UUGCUCCCUUGUUGGUGUUdTsdT	antis

2373-2392	10627	AAAUGAACCCAAAUUAUAC	12627	AAAuGAAcccAAAuuAuAcdTsdT	sense

2373-2392	10628	GUAUAAUUUGGGUUCAUUU	12628	GuAuAAUUUGGGUUcAUUUdTsdT	antis

2431-2450	10629	AAAGGUCUUCCGGCCCCGA	12629	AAAGGucuuccGGccccGAdTsdT	sense

2431-2450	10630	UCGGGGCCGGAAGACCUUU	12630	UCGGGGCCGGAAGACCUUUdTsdT	antis

1632-1651	10631	AGGUAACCACAGUAGUGGC	12631	AGGuAAccAcAGuAGuGGcdTsdT	sense

1632-1651	10632	GCCACUACUGUGGUUACCU	12632	GCcACuACUGUGGUuACCUdTsdT	antis

2031-2050	10633	UAGCCUAUAUCCAUUCCUU	12633	uAGccuAuAuccAuuccuudTsdT	sense

2031-2050	10634	AAGGAAUGGAUAUAGGCUA	12634	AAGGAAUGGAuAuAGGCuAdTsdT	antis

1604-1623	10635	AAAGUUAGCAGAGAUAAAG	12635	AAAGuuAGcAGAGAuAAAGdTsdT	sense

1604-1623	10636	CUUUAUCUCUGCUAACUUU	12636	CUUuAUCUCUGCuAACUUUdTsdT	antis

1605-1624	10637	AAGUUAGCAGAGAUAAAGA	12637	AAGuuAGcAGAGAuAAAGAdTsdT	sense

1605-1624	10638	UCUUUAUCUCUGCUAACUU	12638	UCUUuAUCUCUGCuAACUUdTsdT	antis

1634-1653	10639	GUAACCACAGUAGUGGCAA	12639	GuAAccAcAGuAGuGGcAAdTsdT	sense

1634-1653	10640	UUGCCACUACUGUGGUUAC	12640	UUGCcACuACUGUGGUuACdTsdT	antis

1662-1681	10641	AGGGUCCUGACAGGCCACA	12641	AGGGuccuGAcAGGccAcAdTsdT	sense

1662-1681	10642	UGUGGCCUGUCAGGACCCU	12642	UGUGGCCUGUcAGGACCCUdTsdT	antis

1663-1682	10643	GGGUCCUGACAGGCCACAG	12643	GGGuccuGAcAGGccAcAGdTsdT	sense

1663-1682	10644	CUGUGGCCUGUCAGGACCC	12644	CUGUGGCCUGUcAGGACCCdTsdT	antis

1702-1721	10645	GAAAGUGAUUGGAAAUGGA	12645	GAAAGuGAuuGGAAAuGGAdTsdT	sense

1702-1721	10646	UCCAUUUCCAAUCACUUUC	12646	UCcAUUUCcAAUcACUUUCdTsdT	antis

1772-1791	10647	GCCAUCAAGAAAGUUCUAC	12647	GccAucAAGAAAGuucuAcdTsdT	sense

1772-1791	10648	GUAGAACUUUCUUGAUGGC	12648	GuAGAACUUUCUUGAUGGCdTsdT	antis

1776-1795	10649	UCAAGAAAGUUCUACAGGA	12649	ucAAGAAAGuucuAcAGGAdTsdT	sense

1776-1795	10650	UCCUGUAGAACUUUCUUGA	12650	UCCUGuAGAACUUUCUUGAdTsdT	antis

1792-1811	10651	GGACAAGCGAUUUAAGAAC	12651	GGAcAAGcGAuuuAAGAAcdTsdT	sense

1792-1811	10652	GUUCUUAAAUCGCUUGUCC	12652	GUUCUuAAAUCGCUUGUCCdTsdT	antis

1801-1820	10653	AUUUAAGAACCGAGAGCUC	12653	AuuuAAGAAccGAGAGcucdTsdT	sense

1801-1820	10654	GAGCUCUCGGUUCUUAAAU	12654	GAGCUCUCGGUUCUuAAAUdTsdT	antis

1813-1832	10655	AGAGCUCCAGAUCAUGAGA	12655	AGAGcuccAGAucAuGAGAdTsdT	sense

1813-1832	10656	UCUCAUGAUCUGGAGCUCU	12656	UCUcAUGAUCUGGAGCUCUdTsdT	antis

1859-1878	10657	CUGCGGUAUUUCUUCUACU	12657	cuGcGGuAuuucuucuAcudTsdT	sense

1859-1878	10658	AGUAGAAGAAAUACCGCAG	12658	AGuAGAAGAAAuACCGcAGdTsdT	antis

1860-1879	10659	UGCGGUAUUUCUUCUACUC	12659	uGcGGuAuuucuucuAcucdTsdT	sense

1860-1879	10660	GAGUAGAAGAAAUACCGCA	12660	GAGuAGAAGAAAuACCGcAdTsdT	antis

1900-1919	10661	GGUCUACCUUAACCUGGUG	12661	GGucuAccuuAAccuGGuGdTsdT	sense

1900-1919	10662	CACCAGGUUAAGGUAGACC	12662	cACcAGGUuAAGGuAGACCdTsdT	antis

1909-1928	10663	UAACCUGGUGCUGGACUAU	12663	uAAccuGGuGcuGGAcuAudTsdT	sense

1909-1928	10664	AUAGUCCAGCACCAGGUUA	12664	AuAGUCcAGcACcAGGUuAdTsdT	antis

1982-2001	10665	CUCCCUGUGAUCUAUGUCA	12665	cucccuGuGAucuAuGucAdTsdT	sense

1982-2001	10666	UGACAUAGAUCACAGGGAG	12666	UGAcAuAGAUcAcAGGGAGdTsdT	antis

2125-2144	10667	CUUUGGAAGUGCAAAGCAG	12667	cuuuGGAAGuGcAAAGcAGdTsdT	sense

2125-2144	10668	CUGCUUUGCACUUCCAAAG	12668	CUGCUUUGcACUUCcAAAGdTsdT	antis

2137-2156	10669	AAAGCAGCUGGUCCGAGGA	12669	AAAGcAGcuGGuccGAGGAdTsdT	sense

2137-2156	10670	UCCUCGGACCAGCUGCUUU	12670	UCCUCGGACcAGCUGCUUUdTsdT	antis

2156-2175	10671	GAGCCCAAUGUUUCAUAUA	12671	GAGcccAAuGuuucAuAuAdTsdT	sense

2156-2175	10672	UAUAUGAAACAUUGGGCUC	12672	uAuAUGAAAcAUUGGGCUCdTsdT	antis

2174-2193	10673	AUCUGUUCUCGGUACUACA	12673	AucuGuucucGGuAcuAcAdTsdT	sense

2174-2193	10674	UGUAGUACCGAGAACAGAU	12674	UGuAGuACCGAGAAcAGAUdTsdT	antis

2281-2300	10675	AGGACAACCAAUAUUUCCU	12675	AGGAcAAccAAuAuuuccudTsdT	sense

2281-2300	10676	AGGAAAUAUUGGUUGUCCU	12676	AGGAAAuAUUGGUUGUCCUdTsdT	antis

2282-2301	10677	GGACAACCAAUAUUUCCUG	12677	GGAcAAccAAuAuuuccuGdTsdT	sense

2282-2301	10678	CAGGAAAUAUUGGUUGUCC	12678	cAGGAAAuAUUGGUUGUCCdTsdT	antis

2317-2336	10679	UCAGUUGGUGGAAAUAAUA	12679	ucAGuuGGuGGAAAuAAuAdTsdT	sense

2317-2336	10680	UAUUAUUUCCACCAACUGA	12680	uAUuAUUUCcACcAACUGAdTsdT	antis

2346-2365	10681	GAACACCAACAAGGGAGCA	12681	GAAcAccAAcAAGGGAGcAdTsdT	sense

2346-2365	10682	UGCUCCCUUGUUGGUGUUC	12682	UGCUCCCUUGUUGGUGUUCdTsdT	antis

2401-2420	10683	AUUCCCUCAAAUCAAGGCA	12683	AuucccucAAAucAAGGcAdTsdT	sense

2401-2420	10684	UGCCUUGAUUUGAGGGAAU	12684	UGCCUUGAUUUGAGGGAAUdTsdT	antis

2402-2421	10685	UUCCCUCAAAUCAAGGCAC	12685	uucccucAAAucAAGGcAcdTsdT	sense

2402-2421	10686	GUGCCUUGAUUUGAGGGAA	12686	GUGCCUUGAUUUGAGGGAAdTsdT	antis

2463-2482	10687	CAAUUGCACUGUGCAGCCG	12687	cAAuuGcAcuGuGcAGccGdTsdT	sense

2463-2482	10688	CGGCUGCACAGUGCAAUUG	12688	CGGCUGcAcAGUGcAAUUGdTsdT	antis

1537-1556	10689	ACCGAGAACCACCUCCUUU	12689	AccGAGAAccAccuccuuudTsdT	sense

1537-1556	10690	AAAGGAGGUGGUUCUCGGU	12690	AAAGGAGGUGGUUCUCGGUdTsdT	antis

1554-1573	10691	UUGCGGAGAGCUGCAAGCC	12691	uuGcGGAGAGcuGcAAGccdTsdT	sense

1554-1573	10692	GGCUUGCAGCUCUCCGCAA	12692	GGCUUGcAGCUCUCCGcAAdTsdT	antis

1555-1574	10693	UGCGGAGAGCUGCAAGCCA	12693	uGcGGAGAGcuGcAAGccAdTsdT	sense

1555-1574	10694	UGGCUUGCAGCUCUCCGCA	12694	UGGCUUGcAGCUCUCCGcAdTsdT	antis

1562-1581	10695	AGCUGCAAGCCAGUGCAGC	12695	AGcuGcAAGccAGuGcAGcdTsdT	sense

1562-1581	10696	GCUGCACUGGCUUGCAGCU	12696	GCUGcACUGGCUUGcAGCUdTsdT	antis

1563-1582	10697	GCUGCAAGCCAGUGCAGCA	12697	GcuGcAAGccAGuGcAGcAdTsdT	sense

1563-1582	10698	UGCUGCACUGGCUUGCAGC	12698	UGCUGcACUGGCUUGcAGCdTsdT	antis

1570-1589	10699	GCCAGUGCAGCAGCCUUCA	12699	GccAGuGcAGcAGccuucAdTsdT	sense

1570-1589	10700	UGAAGGCUGCUGCACUGGC	12700	UGAAGGCUGCUGcACUGGCdTsdT	antis

1571-1590	10701	CCAGUGCAGCAGCCUUCAG	12701	ccAGuGcAGcAGccuucAGdTsdT	sense

1571-1590	10702	CUGAAGGCUGCUGCACUGG	12702	CUGAAGGCUGCUGcACUGGdTsdT	antis

1589-1608	10703	GCUUUUGGUAGCAUGAAAG	12703	GcuuuuGGuAGcAuGAAAGdTsdT	sense

1589-1608	10704	CUUUCAUGCUACCAAAAGC	12704	CUUUcAUGCuACcAAAAGCdTsdT	antis

1595-1614	10705	GGUAGCAUGAAAGUUAGCA	12705	GGuAGcAuGAAAGuuAGcAdTsdT	sense

1595-1614	10706	UGCUAACUUUCAUGCUACC	12706	UGCuAACUUUcAUGCuACCdTsdT	antis

1596-1615	10707	GUAGCAUGAAAGUUAGCAG	12707	GuAGcAuGAAAGuuAGcAGdTsdT	sense

1596-1615	10708	CUGCUAACUUUCAUGCUAC	12708	CUGCuAACUUUcAUGCuACdTsdT	antis

1597-1616	10709	UAGCAUGAAAGUUAGCAGA	12709	uAGcAuGAAAGuuAGcAGAdTsdT	sense

1597-1616	10710	UCUGCUAACUUUCAUGCUA	12710	UCUGCuAACUUUcAUGCuAdTsdT	antis

1606-1625	10711	AGUUAGCAGAGAUAAAGAU	12711	AGuuAGcAGAGAuAAAGAudTsdT	sense

1606-1625	10712	AUCUUUAUCUCUGCUAACU	12712	AUCUUuAUCUCUGCuAACUdTsdT	antis

1607-1626	10713	GUUAGCAGAGAUAAAGAUG	12713	GuuAGcAGAGAuAAAGAuGdTsdT	sense

1607-1626	10714	CAUCUUUAUCUCUGCUAAC	12714	cAUCUUuAUCUCUGCuAACdTsdT	antis

1608-1627	10715	UUAGCAGAGAUAAAGAUGG	12715	uuAGcAGAGAuAAAGAuGGdTsdT	sense

1608-1627	10716	CCAUCUUUAUCUCUGCUAA	12716	CcAUCUUuAUCUCUGCuAAdTsdT	antis

1616-1635	10717	GAUAAAGAUGGCAGCAAGG	12717	GAuAAAGAuGGcAGcAAGGdTsdT	sense

1616-1635	10718	CCUUGCUGCCAUCUUUAUC	12718	CCUUGCUGCcAUCUUuAUCdTsdT	antis

1617-1636	10719	AUAAAGAUGGCAGCAAGGU	12719	AuAAAGAuGGcAGcAAGGudTsdT	sense

1617-1636	10720	ACCUUGCUGCCAUCUUUAU	12720	ACCUUGCUGCcAUCUUuAUdTsdT	antis

1638-1657	10721	CCACAGUAGUGGCAACUCC	12721	ccAcAGuAGuGGcAAcuccdTsdT	sense

1638-1657	10722	GGAGUUGCCACUACUGUGG	12722	GGAGUUGCcACuACUGUGGdTsdT	antis

1647-1666	10723	UGGCAACUCCUGGCCAGGG	12723	uGGcAAcuccuGGccAGGGdTsdT	sense

1647-1666	10724	CCCUGGCCAGGAGUUGCCA	12724	CCCUGGCcAGGAGUUGCcAdTsdT	antis

1657-1676	10725	UGGCCAGGGUCCUGACAGG	12725	uGGccAGGGuccuGAcAGGdTsdT	sense

1657-1676	10726	CCUGUCAGGACCCUGGCCA	12726	CCUGUcAGGACCCUGGCcAdTsdT	antis

1660-1679	10727	CCAGGGUCCUGACAGGCCA	12727	ccAGGGuccuGAcAGGccAdTsdT	sense

1660-1679	10728	UGGCCUGUCAGGACCCUGG	12728	UGGCCUGUcAGGACCCUGGdTsdT	antis

1664-1683	10729	GGUCCUGACAGGCCACAGG	12729	GGuccuGAcAGGccAcAGGdTsdT	sense

1664-1683	10730	CCUGUGGCCUGUCAGGACC	12730	CCUGUGGCCUGUcAGGACCdTsdT	antis

1668-1687	10731	CUGACAGGCCACAGGAAGU	12731	cuGAcAGGccAcAGGAAGudTsdT	sense

1668-1687	10732	ACUUCCUGUGGCCUGUCAG	12732	ACUUCCUGUGGCCUGUcAGdTsdT	antis

1692-1711	10733	AUACAGACACGAAAGUGAU	12733	AuAcAGAcAcGAAAGuGAudTsdT	sense

1692-1711	10734	AUCACUUUCGUGUCUGUAU	12734	AUcACUUUCGUGUCUGuAUdTsdT	antis

1694-1713	10735	ACAGACACGAAAGUGAUUG	12735	AcAGAcAcGAAAGuGAuuGdTsdT	sense

1694-1713	10736	CAAUCACUUUCGUGUCUGU	12736	cAAUcACUUUCGUGUCUGUdTsdT	antis

1716-1735	10737	AUGGAUCAUUUGGUGUGGU	12737	AuGGAucAuuuGGuGuGGudTsdT	sense

1716-1735	10738	ACCACACCAAAUGAUCCAU	12738	ACcAcACcAAAUGAUCcAUdTsdT	antis

1730-1749	10739	GUGGUAUAUCAAGCCAAAC	12739	GuGGuAuAucAAGccAAAcdTsdT	sense

1730-1749	10740	GUUUGGCUUGAUAUACCAC	12740	GUUUGGCUUGAuAuACcACdTsdT	antis

1764-1783	10741	AACUGGUUGCCAUCAAGAA	12741	AAcuGGuuGccAucAAGAAdTsdT	sense

1764-1783	10742	UUCUUGAUGGCAACCAGUU	12742	UUCUUGAUGGcAACcAGUUdTsdT	antis

1765-1784	10743	ACUGGUUGCCAUCAAGAAA	12743	AcuGGuuGccAucAAGAAAdTsdT	sense

1765-1784	10744	UUUCUUGAUGGCAACCAGU	12744	UUUCUUGAUGGcAACcAGUdTsdT	antis

1766-1785	10745	CUGGUUGCCAUCAAGAAAG	12745	cuGGuuGccAucAAGAAAGdTsdT	sense

1766-1785	10746	CUUUCUUGAUGGCAACCAG	12746	CUUUCUUGAUGGcAACcAGdTsdT	antis

1771-1790	10747	UGCCAUCAAGAAAGUUCUA	12747	uGccAucAAGAAAGuucuAdTsdT	sense

1771-1790	10748	UAGAACUUUCUUGAUGGCA	12748	uAGAACUUUCUUGAUGGcAdTsdT	antis

1777-1796	10749	CAAGAAAGUUCUACAGGAC	12749	cAAGAAAGuucuAcAGGAcdTsdT	sense

1777-1796	10750	GUCCUGUAGAACUUUCUUG	12750	GUCCUGuAGAACUUUCUUGdTsdT	antis

1811-1830	10751	CGAGAGCUCCAGAUCAUGA	12751	cGAGAGcuccAGAucAuGAdTsdT	sense

1811-1830	10752	UCAUGAUCUGGAGCUCUCG	12752	UcAUGAUCUGGAGCUCUCGdTsdT	antis

1814-1833	10753	GAGCUCCAGAUCAUGAGAA	12753	GAGcuccAGAucAuGAGAAdTsdT	sense

1814-1833	10754	UUCUCAUGAUCUGGAGCUC	12754	UUCUcAUGAUCUGGAGCUCdTsdT	antis

1835-1854	10755	CUAGACCACUGUAACAUAG	12755	cuAGAccAcuGuAAcAuAGdTsdT	sense

1835-1854	10756	CUAUGUUACAGUGGUCUAG	12756	CuAUGUuAcAGUGGUCuAGdTsdT	antis

1881-1900	10757	GUGGUGAGAAGAAAGAUGA	12757	GuGGuGAGAAGAAAGAuGAdTsdT	sense

1881-1900	10758	UCAUCUUUCUUCUCACCAC	12758	UcAUCUUUCUUCUcACcACdTsdT	antis

1882-1901	10759	UGGUGAGAAGAAAGAUGAG	12759	uGGuGAGAAGAAAGAuGAGdTsdT	sense

1882-1901	10760	CUCAUCUUUCUUCUCACCA	12760	CUcAUCUUUCUUCUcACcAdTsdT	antis

1902-1921	10761	UCUACCUUAACCUGGUGCU	12761	ucuAccuuAAccuGGuGcudTsdT	sense

1902-1921	10762	AGCACCAGGUUAAGGUAGA	12762	AGcACcAGGUuAAGGuAGAdTsdT	antis

1914-1933	10763	UGGUGCUGGACUAUGUUCC	12763	uGGuGcuGGAcuAuGuuccdTsdT	sense

1914-1933	10764	GGAACAUAGUCCAGCACCA	12764	GGAAcAuAGUCcAGcACcAdTsdT	antis

1932-1951	10765	CGGAGACAGUGUACAGAGU	12765	cGGAGAcAGuGuAcAGAGudTsdT	sense

1932-1951	10766	ACUCUGUACACUGUCUCCG	12766	ACUCUGuAcACUGUCUCCGdTsdT	antis

1968-1987	10767	GAGCCAAGCAGACACUCCC	12767	GAGccAAGcAGAcAcucccdTsdT	sense

1968-1987	10768	GGGAGUGUCUGCUUGGCUC	12768	GGGAGUGUCUGCUUGGCUCdTsdT	antis

1969-1988	10769	AGCCAAGCAGACACUCCCU	12769	AGccAAGcAGAcAcucccudTsdT	sense

1969-1988	10770	AGGGAGUGUCUGCUUGGCU	12770	AGGGAGUGUCUGCUUGGCUdTsdT	antis

1976-1995	10771	CAGACACUCCCUGUGAUCU	12771	cAGAcAcucccuGuGAucudTsdT	sense

1976-1995	10772	AGAUCACAGGGAGUGUCUG	12772	AGAUcAcAGGGAGUGUCUGdTsdT	antis

2002-2021	10773	GUUGUAUAUGUAUCAGCUG	12773	GuuGuAuAuGuAucAGcuGdTsdT	sense

2002-2021	10774	CAGCUGAUACAUAUACAAC	12774	cAGCUGAuAcAuAuAcAACdTsdT	antis

2013-2032	10775	AUCAGCUGUUCAGAAGUCU	12775	AucAGcuGuucAGAAGucudTsdT	sense

2013-2032	10776	AGACUUCUGAACAGCUGAU	12776	AGACUUCUGAAcAGCUGAUdTsdT	antis

2014-2033	10777	UCAGCUGUUCAGAAGUCUA	12777	ucAGcuGuucAGAAGucuAdTsdT	sense

2014-2033	10778	UAGACUUCUGAACAGCUGA	12778	uAGACUUCUGAAcAGCUGAdTsdT	antis

2032-2051	10779	AGCCUAUAUCCAUUCCUUU	12779	AGccuAuAuccAuuccuuudTsdT	sense

2032-2051	10780	AAAGGAAUGGAUAUAGGCU	12780	AAAGGAAUGGAuAuAGGCUdTsdT	antis

2033-2052	10781	GCCUAUAUCCAUUCCUUUG	12781	GccuAuAuccAuuccuuuGdTsdT	sense

2033-2052	10782	CAAAGGAAUGGAUAUAGGC	12782	cAAAGGAAUGGAuAuAGGCdTsdT	antis

2034-2053	10783	CCUAUAUCCAUUCCUUUGG	12783	ccuAuAuccAuuccuuuGGdTsdT	sense

2034-2053	10784	CCAAAGGAAUGGAUAUAGG	12784	CcAAAGGAAUGGAuAuAGGdTsdT	antis

2037-2056	10785	AUAUCCAUUCCUUUGGAAU	12785	AuAuccAuuccuuuGGAAudTsdT	sense

2037-2056	10786	AUUCCAAAGGAAUGGAUAU	12786	AUUCcAAAGGAAUGGAuAUdTsdT	antis

2038-2057	10787	UAUCCAUUCCUUUGGAAUC	12787	uAuccAuuccuuuGGAAucdTsdT	sense

2038-2057	10788	GAUUCCAAAGGAAUGGAUA	12788	GAUUCcAAAGGAAUGGAuAdTsdT	antis

2041-2060	10789	CCAUUCCUUUGGAAUCUGC	12789	ccAuuccuuuGGAAucuGcdTsdT	sense

2041-2060	10790	GCAGAUUCCAAAGGAAUGG	12790	GcAGAUUCcAAAGGAAUGGdTsdT	antis

2045-2064	10791	UCCUUUGGAAUCUGCCAUC	12791	uccuuuGGAAucuGccAucdTsdT	sense

2045-2064	10792	GAUGGCAGAUUCCAAAGGA	12792	GAUGGcAGAUUCcAAAGGAdTsdT	antis

2069-2088	10793	AUUAAACCACAGAACCUCU	12793	AuuAAAccAcAGAAccucudTsdT	sense

2069-2088	10794	AGAGGUUCUGUGGUUUAAU	12794	AGAGGUUCUGUGGUUuAAUdTsdT	antis

2110-2129	10795	AUUAAAACUCUGUGACUUU	12795	AuuAAAAcucuGuGAcuuudTsdT	sense

2110-2129	10796	AAAGUCACAGAGUUUUAAU	12796	AAAGUcAcAGAGUUUuAAUdTsdT	antis

2111-2130	10797	UUAAAACUCUGUGACUUUG	12797	uuAAAAcucuGuGAcuuuGdTsdT	sense

2111-2130	10798	CAAAGUCACAGAGUUUUAA	12798	cAAAGUcAcAGAGUUUuAAdTsdT	antis

2114-2133	10799	AAACUCUGUGACUUUGGAA	12799	AAAcucuGuGAcuuuGGAAdTsdT	sense

2114-2133	10800	UUCCAAAGUCACAGAGUUU	12800	UUCcAAAGUcAcAGAGUUUdTsdT	antis

2121-2140	10801	GUGACUUUGGAAGUGCAAA	12801	GuGAcuuuGGAAGuGcAAAdTsdT	sense

2121-2140	10802	UUUGCACUUCCAAAGUCAC	12802	UUUGcACUUCcAAAGUcACdTsdT	antis

2122-2141	10803	UGACUUUGGAAGUGCAAAG	12803	uGAcuuuGGAAGuGcAAAGdTsdT	sense

2122-2141	10804	CUUUGCACUUCCAAAGUCA	12804	CUUUGcACUUCcAAAGUcAdTsdT	antis

2127-2146	10805	UUGGAAGUGCAAAGCAGCU	12805	uuGGAAGuGcAAAGcAGcudTsdT	sense

2127-2146	10806	AGCUGCUUUGCACUUCCAA	12806	AGCUGCUUUGcACUUCcAAdTsdT	antis

2128-2147	10807	UGGAAGUGCAAAGCAGCUG	12807	uGGAAGuGcAAAGcAGcuGdTsdT	sense

2128-2147	10808	CAGCUGCUUUGCACUUCCA	12808	cAGCUGCUUUGcACUUCcAdTsdT	antis

2130-2149	10809	GAAGUGCAAAGCAGCUGGU	12809	GAAGuGcAAAGcAGcuGGudTsdT	sense

2130-2149	10810	ACCAGCUGCUUUGCACUUC	12810	ACcAGCUGCUUUGcACUUCdTsdT	antis

2144-2163	10811	CUGGUCCGAGGAGAGCCCA	12811	cuGGuccGAGGAGAGcccAdTsdT	sense

2144-2163	10812	UGGGCUCUCCUCGGACCAG	12812	UGGGCUCUCCUCGGACcAGdTsdT	antis

2145-2164	10813	UGGUCCGAGGAGAGCCCAA	12813	uGGuccGAGGAGAGcccAAdTsdT	sense

2145-2164	10814	UUGGGCUCUCCUCGGACCA	12814	UUGGGCUCUCCUCGGACcAdTsdT	antis

2152-2171	10815	AGGAGAGCCCAAUGUUUCA	12815	AGGAGAGcccAAuGuuucAdTsdT	sense

2152-2171	10816	UGAAACAUUGGGCUCUCCU	12816	UGAAAcAUUGGGCUCUCCUdTsdT	antis

2173-2192	10817	UAUCUGUUCUCGGUACUAC	12817	uAucuGuucucGGuAcuAcdTsdT	sense

2173-2192	10818	GUAGUACCGAGAACAGAUA	12818	GuAGuACCGAGAAcAGAuAdTsdT	antis

2244-2263	10819	UAUGGUCUGCAGGCUGUGU	12819	uAuGGucuGcAGGcuGuGudTsdT	sense

2244-2263	10820	ACACAGCCUGCAGACCAUA	12820	AcAcAGCCUGcAGACcAuAdTsdT	antis

2293-2312	10821	AUUUCCUGGGGACAGUGGU	12821	AuuuccuGGGGAcAGuGGudTsdT	sense

2293-2312	10822	ACCACUGUCCCCAGGAAAU	12822	ACcACUGUCCCcAGGAAAUdTsdT	antis

2296-2315	10823	UCCUGGGGACAGUGGUGUG	12823	uccuGGGGAcAGuGGuGuGdTsdT	sense

2296-2315	10824	CACACCACUGUCCCCAGGA	12824	cAcACcACUGUCCCcAGGAdTsdT	antis

2297-2316	10825	CCUGGGGACAGUGGUGUGG	12825	ccuGGGGAcAGuGGuGuGGdTsdT	sense

2297-2316	10826	CCACACCACUGUCCCCAGG	12826	CcAcACcACUGUCCCcAGGdTsdT	antis

2320-2339	10827	GUUGGUGGAAAUAAUAAAG	12827	GuuGGuGGAAAuAAuAAAGdTsdT	sense

2320-2339	10828	CUUUAUUAUUUCCACCAAC	12828	CUUuAUuAUUUCcACcAACdTsdT	antis

2321-2340	10829	UUGGUGGAAAUAAUAAAGG	12829	uuGGuGGAAAuAAuAAAGGdTsdT	sense

2321-2340	10830	CCUUUAUUAUUUCCACCAA	12830	CCUUuAUuAUUUCcACcAAdTsdT	antis

2322-2341	10831	UGGUGGAAAUAAUAAAGGU	12831	uGGuGGAAAuAAuAAAGGudTsdT	sense

2322-2341	10832	ACCUUUAUUAUUUCCACCA	12832	ACCUUuAUuAUUUCcACcAdTsdT	antis

2348-2367	10833	ACACCAACAAGGGAGCAAA	12833	AcAccAAcAAGGGAGcAAAdTsdT	sense

2348-2367	10834	UUUGCUCCCUUGUUGGUGU	12834	UUUGCUCCCUUGUUGGUGUdTsdT	antis

2349-2368	10835	CACCAACAAGGGAGCAAAU	12835	cAccAAcAAGGGAGcAAAudTsdT	sense

2349-2368	10836	AUUUGCUCCCUUGUUGGUG	12836	AUUUGCUCCCUUGUUGGUGdTsdT	antis

2389-2408	10837	UACAGAAUUCAAAUUCCCU	12837	uAcAGAAuucAAAuucccudTsdT	sense

2389-2408	10838	AGGGAAUUUGAAUUCUGUA	12838	AGGGAAUUUGAAUUCUGuAdTsdT	antis

2414-2433	10839	AAGGCACAUCCUUGGACAA	12839	AAGGcAcAuccuuGGAcAAdTsdT	sense

2414-2433	10840	UUGUCCAAGGAUGUGCCUU	12840	UUGUCcAAGGAUGUGCCUUdTsdT	antis

2419-2438	10841	ACAUCCUUGGACAAAGGUC	12841	AcAuccuuGGAcAAAGGucdTsdT	sense

2419-2438	10842	GACCUUUGUCCAAGGAUGU	12842	GACCUUUGUCcAAGGAUGUdTsdT	antis

2429-2448	10843	ACAAAGGUCUUCCGGCCCC	12843	AcAAAGGucuuccGGccccdTsdT	sense

2429-2448	10844	GGGGCCGGAAGACCUUUGU	12844	GGGGCCGGAAGACCUUUGUdTsdT	antis

2460-2479	10845	AGGCAAUUGCACUGUGCAG	12845	AGGcAAuuGcAcuGuGcAGdTsdT	sense

2460-2479	10846	CUGCACAGUGCAAUUGCCU	12846	CUGcAcAGUGcAAUUGCCUdTsdT	antis

2474-2493	10847	UGCAGCCGUCUGCUGGAGU	12847	uGcAGccGucuGcuGGAGudTsdT	sense

2474-2493	10848	ACUCCAGCAGACGGCUGCA	12848	ACUCcAGcAGACGGCUGcAdTsdT	antis

2480-2499	10849	CGUCUGCUGGAGUACACAC	12849	cGucuGcuGGAGuAcAcAcdTsdT	sense

2480-2499	10850	GUGUGUACUCCAGCAGACG	12850	GUGUGuACUCcAGcAGACGdTsdT	antis

2481-2500	10851	GUCUGCUGGAGUACACACC	12851	GucuGcuGGAGuAcAcAccdTsdT	sense

2481-2500	10852	GGUGUGUACUCCAGCAGAC	12852	GGUGUGuACUCcAGcAGACdTsdT	antis

2511-2530	10853	UAACACCACUGGAAGCUUG	12853	uAAcAccAcuGGAAGcuuGdTsdT	sense

2511-2530	10854	CAAGCUUCCAGUGGUGUUA	12854	cAAGCUUCcAGUGGUGUuAdTsdT	antis

1540-1559	10855	GAGAACCACCUCCUUUGCG	12855	GAGAAccAccuccuuuGcGdTsdT	sense

1540-1559	10856	CGCAAAGGAGGUGGUUCUC	12856	CGcAAAGGAGGUGGUUCUCdTsdT	antis

1883-1902	10857	GGUGAGAAGAAAGAUGAGG	12857	GGuGAGAAGAAAGAuGAGGdTsdT	sense

1883-1902	10858	CCUCAUCUUUCUUCUCACC	12858	CCUcAUCUUUCUUCUcACCdTsdT	antis

2044-2063	10859	UUCCUUUGGAAUCUGCCAU	12859	uuccuuuGGAAucuGccAudTsdT	sense

2044-2063	10860	AUGGCAGAUUCCAAAGGAA	12860	AUGGcAGAUUCcAAAGGAAdTsdT	antis

2205-2224	10861	UGAUCUUUGGAGCCACUGA	12861	uGAucuuuGGAGccAcuGAdTsdT	sense

2205-2224	10862	UCAGUGGCUCCAAAGAUCA	12862	UcAGUGGCUCcAAAGAUcAdTsdT	antis

2331-2350	10863	UAAUAAAGGUCCUAGGAAC	12863	uAAuAAAGGuccuAGGAAcdTsdT	sense

2331-2350	10864	GUUCCUAGGACCUUUAUUA	12864	GUUCCuAGGACCUUuAUuAdTsdT	antis

2384-2403	10865	AAUUAUACAGAAUUCAAAU	12865	AAuuAuAcAGAAuucAAAudTsdT	sense

2384-2403	10866	AUUUGAAUUCUGUAUAAUU	12866	AUUUGAAUUCUGuAuAAUUdTsdT	antis

1557-1576	10867	CGGAGAGCUGCAAGCCAGU	12867	cGGAGAGcuGcAAGccAGudTsdT	sense

1557-1576	10868	ACUGGCUUGCAGCUCUCCG	12868	ACUGGCUUGcAGCUCUCCGdTsdT	antis

1567-1586	10869	CAAGCCAGUGCAGCAGCCU	12869	cAAGccAGuGcAGcAGccudTsdT	sense

1567-1586	10870	AGGCUGCUGCACUGGCUUG	12870	AGGCUGCUGcACUGGCUUGdTsdT	antis

1568-1587	10871	AAGCCAGUGCAGCAGCCUU	12871	AAGccAGuGcAGcAGccuudTsdT	sense

1568-1587	10872	AAGGCUGCUGCACUGGCUU	12872	AAGGCUGCUGcACUGGCUUdTsdT	antis

1580-1599	10873	CAGCCUUCAGCUUUUGGUA	12873	cAGccuucAGcuuuuGGuAdTsdT	sense

1580-1599	10874	UACCAAAAGCUGAAGGCUG	12874	uACcAAAAGCUGAAGGCUGdTsdT	antis

1583-1602	10875	CCUUCAGCUUUUGGUAGCA	12875	ccuucAGcuuuuGGuAGcAdTsdT	sense

1583-1602	10876	UGCUACCAAAAGCUGAAGG	12876	UGCuACcAAAAGCUGAAGGdTsdT	antis

1590-1609	10877	CUUUUGGUAGCAUGAAAGU	12877	cuuuuGGuAGcAuGAAAGudTsdT	sense

1590-1609	10878	ACUUUCAUGCUACCAAAAG	12878	ACUUUcAUGCuACcAAAAGdTsdT	antis

1609-1628	10879	UAGCAGAGAUAAAGAUGGC	12879	uAGcAGAGAuAAAGAuGGcdTsdT	sense

1609-1628	10880	GCCAUCUUUAUCUCUGCUA	12880	GCcAUCUUuAUCUCUGCuAdTsdT	antis

1615-1634	10881	AGAUAAAGAUGGCAGCAAG	12881	AGAuAAAGAuGGcAGcAAGdTsdT	sense

1615-1634	10882	CUUGCUGCCAUCUUUAUCU	12882	CUUGCUGCcAUCUUuAUCUdTsdT	antis

1655-1674	10883	CCUGGCCAGGGUCCUGACA	12883	ccuGGccAGGGuccuGAcAdTsdT	sense

1655-1674	10884	UGUCAGGACCCUGGCCAGG	12884	UGUcAGGACCCUGGCcAGGdTsdT	antis

1671-1690	10885	ACAGGCCACAGGAAGUCAG	12885	AcAGGccAcAGGAAGucAGdTsdT	sense

1671-1690	10886	CUGACUUCCUGUGGCCUGU	12886	CUGACUUCCUGUGGCCUGUdTsdT	antis

1672-1691	10887	CAGGCCACAGGAAGUCAGU	12887	cAGGccAcAGGAAGucAGudTsdT	sense

1672-1691	10888	ACUGACUUCCUGUGGCCUG	12888	ACUGACUUCCUGUGGCCUGdTsdT	antis

1747-1766	10889	ACUUUGUGAUUCUGGAGAA	12889	AcuuuGuGAuucuGGAGAAdTsdT	sense

1747-1766	10890	UUCUCCAGAAUCACAAAGU	12890	UUCUCcAGAAUcAcAAAGUdTsdT	antis

1748-1767	10891	CUUUGUGAUUCUGGAGAAC	12891	cuuuGuGAuucuGGAGAAcdTsdT	sense

1748-1767	10892	GUUCUCCAGAAUCACAAAG	12892	GUUCUCcAGAAUcAcAAAGdTsdT	antis

1750-1769	10893	UUGUGAUUCUGGAGAACUG	12893	uuGuGAuucuGGAGAAcuGdTsdT	sense

1750-1769	10894	CAGUUCUCCAGAAUCACAA	12894	cAGUUCUCcAGAAUcAcAAdTsdT	antis

1751-1770	10895	UGUGAUUCUGGAGAACUGG	12895	uGuGAuucuGGAGAAcuGGdTsdT	sense

1751-1770	10896	CCAGUUCUCCAGAAUCACA	12896	CcAGUUCUCcAGAAUcAcAdTsdT	antis

1752-1771	10897	GUGAUUCUGGAGAACUGGU	12897	GuGAuucuGGAGAAcuGGudTsdT	sense

1752-1771	10898	ACCAGUUCUCCAGAAUCAC	12898	ACcAGUUCUCcAGAAUcACdTsdT	antis

1753-1772	10899	UGAUUCUGGAGAACUGGUU	12899	uGAuucuGGAGAAcuGGuudTsdT	sense

1753-1772	10900	AACCAGUUCUCCAGAAUCA	12900	AACcAGUUCUCcAGAAUcAdTsdT	antis

2117-2136	10901	CUCUGUGACUUUGGAAGUG	12901	cucuGuGAcuuuGGAAGuGdTsdT	sense

2117-2136	10902	CACUUCCAAAGUCACAGAG	12902	cACUUCcAAAGUcAcAGAGdTsdT	antis

2118-2137	10903	UCUGUGACUUUGGAAGUGC	12903	ucuGuGAcuuuGGAAGuGcdTsdT	sense

2118-2137	10904	GCACUUCCAAAGUCACAGA	12904	GcACUUCcAAAGUcAcAGAdTsdT	antis

2148-2167	10905	UCCGAGGAGAGCCCAAUGU	12905	uccGAGGAGAGcccAAuGudTsdT	sense

2148-2167	10906	ACAUUGGGCUCUCCUCGGA	12906	AcAUUGGGCUCUCCUCGGAdTsdT	antis

2202-2221	10907	AGUUGAUCUUUGGAGCCAC	12907	AGuuGAucuuuGGAGccAcdTsdT	sense

2202-2221	10908	GUGGCUCCAAAGAUCAACU	12908	GUGGCUCcAAAGAUcAACUdTsdT	antis

2203-2222	10909	GUUGAUCUUUGGAGCCACU	12909	GuuGAucuuuGGAGccAcudTsdT	sense

2203-2222	10910	AGUGGCUCCAAAGAUCAAC	12910	AGUGGCUCcAAAGAUcAACdTsdT	antis

2204-2223	10911	UUGAUCUUUGGAGCCACUG	12911	uuGAucuuuGGAGccAcuGdTsdT	sense

2204-2223	10912	CAGUGGCUCCAAAGAUCAA	12912	cAGUGGCUCcAAAGAUcAAdTsdT	antis

2206-2225	10913	GAUCUUUGGAGCCACUGAU	12913	GAucuuuGGAGccAcuGAudTsdT	sense

2206-2225	10914	AUCAGUGGCUCCAAAGAUC	12914	AUcAGUGGCUCcAAAGAUCdTsdT	antis

2245-2264	10915	AUGGUCUGCAGGCUGUGUG	12915	AuGGucuGcAGGcuGuGuGdTsdT	sense

2245-2264	10916	CACACAGCCUGCAGACCAU	12916	cAcAcAGCCUGcAGACcAUdTsdT	antis

2252-2271	10917	GCAGGCUGUGUGUUGGCUG	12917	GcAGGcuGuGuGuuGGcuGdTsdT	sense

2252-2271	10918	CAGCCAACACACAGCCUGC	12918	cAGCcAAcAcAcAGCCUGCdTsdT	antis

2266-2285	10919	GGCUGAAUUGUUGCUAGGA	12919	GGcuGAAuuGuuGcuAGGAdTsdT	sense

2266-2285	10920	UCCUAGCAACAAUUCAGCC	12920	UCCuAGcAAcAAUUcAGCCdTsdT	antis

2294-2313	10921	UUUCCUGGGGACAGUGGUG	12921	uuuccuGGGGAcAGuGGuGdTsdT	sense

2294-2313	10922	CACCACUGUCCCCAGGAAA	12922	cACcACUGUCCCcAGGAAAdTsdT	antis

2295-2314	10923	UUCCUGGGGACAGUGGUGU	12923	uuccuGGGGAcAGuGGuGudTsdT	sense

2295-2314	10924	ACACCACUGUCCCCAGGAA	12924	AcACcACUGUCCCcAGGAAdTsdT	antis

2350-2369	10925	ACCAACAAGGGAGCAAAUU	12925	AccAAcAAGGGAGcAAAuudTsdT	sense

2350-2369	10926	AAUUUGCUCCCUUGUUGGU	12926	AAUUUGCUCCCUUGUUGGUdTsdT	antis

2382-2401	10927	CAAAUUAUACAGAAUUCAA	12927	cAAAuuAuAcAGAAuucAAdTsdT	sense

2382-2401	10928	UUGAAUUCUGUAUAAUUUG	12928	UUGAAUUCUGuAuAAUUUGdTsdT	antis

1543-1562	10929	AACCACCUCCUUUGCGGAG	12929	AAccAccuccuuuGcGGAGdTsdT	sense

1543-1562	10930	CUCCGCAAAGGAGGUGGUU	12930	CUCCGcAAAGGAGGUGGUUdTsdT	antis

1544-1563	10931	ACCACCUCCUUUGCGGAGA	12931	AccAccuccuuuGcGGAGAdTsdT	sense

1544-1563	10932	UCUCCGCAAAGGAGGUGGU	12932	UCUCCGcAAAGGAGGUGGUdTsdT	antis

1545-1564	10933	CCACCUCCUUUGCGGAGAG	12933	ccAccuccuuuGcGGAGAGdTsdT	sense

1545-1564	10934	CUCUCCGCAAAGGAGGUGG	12934	CUCUCCGcAAAGGAGGUGGdTsdT	antis

1712-1731	10935	GGAAAUGGAUCAUUUGGUG	12935	GGAAAuGGAucAuuuGGuGdTsdT	sense

1712-1731	10936	CACCAAAUGAUCCAUUUCC	12936	cACcAAAUGAUCcAUUUCCdTsdT	antis

1879-1898	10937	GAGUGGUGAGAAGAAAGAU	12937	GAGuGGuGAGAAGAAAGAudTsdT	sense

1879-1898	10938	AUCUUUCUUCUCACCACUC	12938	AUCUUUCUUCUcACcACUCdTsdT	antis

2060-2079	10939	CAUCGAGACAUUAAACCAC	12939	cAucGAGAcAuuAAAccAcdTsdT	sense

2060-2079	10940	GUGGUUUAAUGUCUCGAUG	12940	GUGGUUuAAUGUCUCGAUGdTsdT	antis

2062-2081	10941	UCGAGACAUUAAACCACAG	12941	ucGAGAcAuuAAAccAcAGdTsdT	sense

2062-2081	10942	CUGUGGUUUAAUGUCUCGA	12942	CUGUGGUUuAAUGUCUCGAdTsdT	antis

2061-2080	10943	AUCGAGACAUUAAACCACA	12943	AucGAGAcAuuAAAccAcAdTsdT	sense

2061-2080	10944	UGUGGUUUAAUGUCUCGAU	12944	UGUGGUUuAAUGUCUCGAUdTsdT	antis

2058-2077	10945	GCCAUCGAGACAUUAAACC	12945	GccAucGAGAcAuuAAAccdTsdT	sense

2058-2077	10946	GGUUUAAUGUCUCGAUGGC	12946	GGUUuAAUGUCUCGAUGGCdTsdT	antis

2059-2078	10947	CCAUCGAGACAUUAAACCA	12947	ccAucGAGAcAuuAAAccAdTsdT	sense

2059-2078	10948	UGGUUUAAUGUCUCGAUGG	12948	UGGUUuAAUGUCUCGAUGGdTsdT	antis

1639-1658	10949	CACAGUAGUGGCAACUCCU	12949	cAcAGuAGuGGcAAcuccudTsdT	sense

1639-1658	10950	AGGAGUUGCCACUACUGUG	12950	AGGAGUUGCcACuACUGUGdTsdT	antis

2064-2083	10951	GAGACAUUAAACCACAGAA	12951	GAGAcAuuAAAccAcAGAAdTsdT	sense

2064-2083	10952	UUCUGUGGUUUAAUGUCUC	12952	UUCUGUGGUUuAAUGUCUCdTsdT	antis

1641-1660	10953	CAGUAGUGGCAACUCCUGG	12953	cAGuAGuGGcAAcuccuGGdTsdT	sense

1641-1660	10954	CCAGGAGUUGCCACUACUG	12954	CcAGGAGUUGCcACuACUGdTsdT	antis

1812-1831	10955	GAGAGCUCCAGAUCAUGAG	12955	GAGAGcuccAGAucAuGAGdTsdT	sense

1812-1831	10956	CUCAUGAUCUGGAGCUCUC	12956	CUcAUGAUCUGGAGCUCUCdTsdT	antis

2063-2082	10957	CGAGACAUUAAACCACAGA	12957	cGAGAcAuuAAAccAcAGAdTsdT	sense

2063-2082	10958	UCUGUGGUUUAAUGUCUCG	12958	UCUGUGGUUuAAUGUCUCGdTsdT	antis

2065-2084	10959	AGACAUUAAACCACAGAAC	12959	AGAcAuuAAAccAcAGAAcdTsdT	sense

2065-2084	10960	GUUCUGUGGUUUAAUGUCU	12960	GUUCUGUGGUUuAAUGUCUdTsdT	antis

2112-2131	10961	UAAAACUCUGUGACUUUGG	12961	uAAAAcucuGuGAcuuuGGdTsdT	sense

2112-2131	10962	CCAAAGUCACAGAGUUUUA	12962	CcAAAGUcAcAGAGUUUuAdTsdT	antis

2119-2138	10963	CUGUGACUUUGGAAGUGCA	12963	cuGuGAcuuuGGAAGuGcAdTsdT	sense

2119-2138	10964	UGCACUUCCAAAGUCACAG	12964	UGcACUUCcAAAGUcAcAGdTsdT	antis

2123-2142	10965	GACUUUGGAAGUGCAAAGC	12965	GAcuuuGGAAGuGcAAAGcdTsdT	sense

2123-2142	10966	GCUUUGCACUUCCAAAGUC	12966	GCUUUGcACUUCcAAAGUCdTsdT	antis

2131-2150	10967	AAGUGCAAAGCAGCUGGUC	12967	AAGuGcAAAGcAGcuGGucdTsdT	sense

2131-2150	10968	GACCAGCUGCUUUGCACUU	12968	GACcAGCUGCUUUGcACUUdTsdT	antis

1715-1734	10969	AAUGGAUCAUUUGGUGUGG	12969	AAuGGAucAuuuGGuGuGGdTsdT	sense

1715-1734	10970	CCACACCAAAUGAUCCAUU	12970	CcAcACcAAAUGAUCcAUUdTsdT	antis

2482-2501	10971	UCUGCUGGAGUACACACCU	12971	ucuGcuGGAGuAcAcAccudTsdT	sense

2482-2501	10972	AGGUGUGUACUCCAGCAGA	12972	AGGUGUGuACUCcAGcAGAdTsdT	antis

1714-1733	10973	AAAUGGAUCAUUUGGUGUG	12973	AAAuGGAucAuuuGGuGuGdTsdT	sense

1714-1733	10974	CACACCAAAUGAUCCAUUU	12974	cAcACcAAAUGAUCcAUUUdTsdT	antis

1884-1903	10975	GUGAGAAGAAAGAUGAGGU	12975	GuGAGAAGAAAGAuGAGGudTsdT	sense

1884-1903	10976	ACCUCAUCUUUCUUCUCAC	12976	ACCUcAUCUUUCUUCUcACdTsdT	antis

2039-2058	10977	AUCCAUUCCUUUGGAAUCU	12977	AuccAuuccuuuGGAAucudTsdT	sense

2039-2058	10978	AGAUUCCAAAGGAAUGGAU	12978	AGAUUCcAAAGGAAUGGAUdTsdT	antis

2113-2132	10979	AAAACUCUGUGACUUUGGA	12979	AAAAcucuGuGAcuuuGGAdTsdT	sense

2113-2132	10980	UCCAAAGUCACAGAGUUUU	12980	UCcAAAGUcAcAGAGUUUUdTsdT	antis

2246-2265	10981	UGGUCUGCAGGCUGUGUGU	12981	uGGucuGcAGGcuGuGuGudTsdT	sense

2246-2265	10982	ACACACAGCCUGCAGACCA	12982	AcAcAcAGCCUGcAGACcAdTsdT	antis

1713-1732	10983	GAAAUGGAUCAUUUGGUGU	12983	GAAAuGGAucAuuuGGuGudTsdT	sense

1713-1732	10984	ACACCAAAUGAUCCAUUUC	12984	AcACcAAAUGAUCcAUUUCdTsdT	antis

TABLE 4

Sequences of duplexes targeting Mouse GSK3-alpha
Target sequence start identifies first nucleotide in target
sequence in mouse GSK3-alpha mRNA NM_001031667.1. Unmodified
sense strand is identical to target sequence. Unmodified
antisense strand is complementary to target sequence.

	Target	SEQ		SEQ
	sequence	ID		ID
Duplex	start	NO:		NO:

			unmodified		unmodified
			sense strand		antisense strand
			5′ to 3′		5′ to 3′
AD-18821	670	12985	AACUGCAGAUUAUGCGUAA	12996	UUACGCAUAAUCUGCAGUU

AD-18823	330	12986	GGCGGCGGGAAAGCGUCAG	12997	CUGACGCUUUCCCGCCGCC

AD-18824	239	12987	GGCGCGGACCAGCUCGUUC	12998	GAACGAGCUGGUCCGCGCC

AD-18825	1340	12988	CCUACUGGAGUACACGCCA	12999	UGGCGUGUACUCCAGUAGG

AD-18826	1342	12989	UACUGGAGUACACGCCAUC	13000	GAUGGCGUGUACUCCAGUA

AD-18827	1073	12990	CACAGAUUACACCUCGUCC	13001	GGACGAGGUGUAAUCUGUG

AD-18828	1236	12991	CCUAACUAUACGGAGUUCA	13002	UGAACUCCGUAUAGUUAGG

AD-18829	435	12992	GCGGGCACUAGCUUCCCGC	13003	GCGGGAAGCUAGUGCCCGC

AD-18830	1231	12993	UGAACCCUAACUAUACGGA	13004	UCCGUAUAGUUAGGGUUCA

AD-18831	1234	12994	ACCCUAACUAUACGGAGUU	13005	AACUCCGUAUAGUUAGGGU

AD-18832	1235	12995	CCCUAACUAUACGGAGUUC	13006	GAACUCCGUAUAGUUAGGG

			modified		modified
			sense strand		antisense strand
			5′ to 3′		5′ to 3′
AD-18821-b1	670	13007	AAcuGcAGAuuAuGcGuAAdTsdT	13018	UuACGcAuAAUCUGcAGUUdTsdT

AD-18823-b1	330	13008	GGcGGcGGGAAAGcGucAGdTsdT	13019	CUGACGCUUUCCCGCCGCCdTsdT

AD-18824-b1	239	13009	GGcGcGGAccAGcucGuucdTsdT	13020	GAACGAGCUGGUCCGCGCCdTsdT

AD-18825-b1	1340	13010	ccuAcuGGAGuAcAcGccAdTsdT	13021	UGGCGUGuACUCcAGuAGGdTsdT

AD-18826-b1	1342	13011	uAcuGGAGuAcAcGccAucdTsdT	13022	GAUGGCGUGuACUCcAGuAdTsdT

AD-18827-b1	1073	13012	cAcAGAuuAcAccucGuccdTsdT	13023	GGACGAGGUGuAAUCUGUGdTsdT

AD-18828-b1	1236	13013	ccuAAcuAuAcGGAGuucAdTsdT	13024	UGAACUCCGuAuAGUuAGGdTsdT

AD-18829-b1	435	13014	GcGGGcAcuAGcuucccGcdTsdT	13025	GCGGGAAGCuAGUGCCCGCdTsdT

AD-18830-b1	1231	13015	uGAAcccuAAcuAuAcGGAdTsdT	13026	UCCGuAuAGUuAGGGUUcAdTsdT

AD-18831-b1	1234	13016	AcccuAAcuAuAcGGAGuudTsdT	13027	AACUCCGuAuAGUuAGGGUdTsdT

AD-18832-b1	1235	13017	cccuAAcuAuAcGGAGuucdTsdT	13028	GAACUCCGuAuAGUuAGGGdTsdT

TABLE 5

Sequences of duplexes targeting Mouse GSK3-beta
Target sequence start identifies first nucleotide in target
sequence in mouse GSK3-beta mRNA NM_019827.6. Unmodified
sense strand is identical to target sequence. Unmodified
antisense strand is complementary to target sequence.

	Target	SEQ		SEQ
	sequence	ID		ID
Duplex	start	NO:		NO:

			unmodified		unmodified
			sense strand		antisense strand
			5′ to 3′		5′ to 3′
AD-18833	1842	13029	ACUGUAACAUAGUCCGACU	13040	AGUCGGACUAUGUUACAGU

AD-18834	1843	13030	CUGUAACAUAGUCCGACUG	13041	CAGUCGGACUAUGUUACAG

AD-18835	1952	13031	GCCAGACACUAUAGUCGAG	13042	CUCGACUAUAGUGUCUGGC

AD-18836	1847	13032	AACAUAGUCCGACUGCGGU	13043	ACCGCAGUCGGACUAUGUU

AD-18837	1838	13033	GACCACUGUAACAUAGUCC	13044	GGACUAUGUUACAGUGGUC

AD-18838	1846	13034	UAACAUAGUCCGACUGCGG	13045	CCGCAGUCGGACUAUGUUA

AD-18839	1849	13035	CAUAGUCCGACUGCGGUAU	13046	AUACCGCAGUCGGACUAUG

AD-18841	1957	13036	ACACUAUAGUCGAGCCAAG	13047	CUUGGCUCGACUAUAGUGU

AD-18842	2169	13037	CAUAUAUCUGUUCUCGGUA	13048	UACCGAGAACAGAUAUAUG

AD-18843	1788	13038	UACAGGACAAGCGAUUUAA	13049	UUAAAUCGCUUGUCCUGUA

AD-18844	1862	13039	ACUGUAACAUAGUCCGACU	13050	UCGAGUAGAAGAAAUACCG

			modified		modified
			sense strand		antisense strand
			5′ to 3′		5′ to 3′
AD-18833-b1	1842	13051	AcuGuAAcAuAGuccGAcudTsdT	13062	AGUCGGACuAUGUuAcAGUdTsdT

AD-18834-b1	1843	13052	cuGuAAcAuAGuccGAcuGdTsdT	13063	cAGUCGGACuAUGUuAcAGdTsdT

AD-18835-b1	1952	13053	GccAGAcAcuAuAGucGAGdTsdT	13064	CUCGACuAuAGUGUCUGGCdTsdT

AD-18836-b1	1847	13054	AAcAuAGuccGAcuGcGGudTsdT	13065	ACCGcAGUCGGACuAUGUUdTsdT

AD-18837-b1	1838	13055	GAccAcuGuAAcAuAGuccdTsdT	13066	GGACuAUGUuAcAGUGGUCdTsdT

AD-18838-b1	1846	13056	uAAcAuAGuccGAcuGcGGdTsdT	13067	CCGcAGUCGGACuAUGUuAdTsdT

AD-18839-b1	1849	13057	cAuAGuccGAcuGcGGuAudTsdT	13068	AuACCGcAGUCGGACuAUGdTsdT

AD-18841-b1	1957	13058	AcAcuAuAGucGAGccAAGdTsdT	13069	CUUGGCUCGACuAuAGUGUdTsdT

AD-18842-b1	2169	13059	cAuAuAucuGuucucGGuAdTsdT	13070	uACCGAGAAcAGAuAuAUGdTsdT

AD-18843-b1	1788	13060	uAcAGGAcAAGcGAuuuAAdTsdT	13071	UuAAAUCGCUUGUCCUGuAdTsdT

AD-18844-b1	1862	13061	cGGuAuuucuucuAcucGAdTsdT	13072	UCGAGuAGAAGAAAuACCGdTsdT

TABLE 6

Sequences of duplexes targeting Human GSK3-alpha
Target sequence start identifies first nucleotide in target
sequence in human GSK3-alpha mRNA NM_002093. Unmodified
sense strand is identical to target sequence. Unmodified
antisense strand is complementary to target sequence.

	Target	SEQ	unmodified	SEQ	unmodified
	sequence	ID	sense strand	ID	antisense strand
Duplex	start	NO:	5′ to 3′	NO:	5′ to 3′

huGSKA-1	1273	13073	AGCUCCAGAUCAUGAGAAA	13081	UUUCUCAUGAUCUGGAGCU

huGSKA-2	1979	13074	UCUGCUGGAGUAUACACCA	13082	UGGUGUAUACUCCAGCAGA

huGSKA-3	1981	13075	UGCUGGAGUAUACACCAAC	13083	GUUGGUGUAUACUCCAGCA

huGSKA-4	1676	13076	CACUGAUUAUACCUCUAGU	13084	ACUAGAGGUAUAAUCAGUG

huGSKA-5	1839	13077	CCAAACUACACAGAAUUUA	13085	UAAAUUCUGUGUAGUUUGG

huGSKA-6	1834	13078	UGAACCCAAACUACACAGA	13086	UCUGUGUAGUUUGGGUUCA

huGSKA-7	1837	13079	ACCCAAACUACACAGAAUU	13087	AAUUCUGUGUAGUUUGGGU

huGSKA-8	1838	13080	CCCAAACUACACAGAAUUU	13088	AAAUUCUGUGUAGUUUGGG

Human GSK alpha duplexes correspond to the mouse GSK alpha duplexes as follows:


	Mouse duplex	Human duplex

	AD-18821	huGSKA-1
	AD-18825	huGSKA-2
	AD-18826	huGSKA-3
	AD-18827	huGSKA-4
	AD-18828	huGSKA-5
	AD-18830	huGSKA-6
	AD-18831	huGSKA-7
	AD-18832	huGSKA-8

TABLE 7

Sequences of duplexes targeting Human GSK3-beta
Target sequence start identifies first nucleotide in target
sequence in human GSK3-beta mRNA NM_019884. Unmodified
sense strand is identical to target sequence. Unmodified
antisense strand is complementary to target sequence.

	Target	SEQ	unmodified	SEQ	unmodified
	sequence	ID	antisense strand	ID	sense strand
Duplex	start	NO:	5′ to 3′	NO:	5′ to 3′

huGSKB-1	625	13088	ACUGCAAUAUUGUGAGGCU	13099	AGCCUCACAAUAUUGCAGU

huGSKB-2	626	13089	CUGCAAUAUUGUGAGGCUG	13100	CAGCCUCACAAUAUUGCAG

huGSKB-3	735	13090	GCCCGCCACUUCACCAAGG	13101	CCUUGGUGAAGUGGCGGGC

huGSKB-4	630	13091	AAUAUUGUGAGGCUGAGAU	13102	AUCUCAGCCUCACAAUAUU

huGSKB-5	621	13092	GACCACUGCAAUAUUGUGA	13103	UCACAAUAUUGCAGUGGUC

huGSKB-6	629	13093	CAAUAUUGUGAGGCUGAGA	13104	UCUCAGCCUCACAAUAUUG

huGSKB-7	632	13094	UAUUGUGAGGCUGAGAUAC	13105	GUAUCUCAGCCUCACAAUA

huGSKB-8	740	13095	CCACUUCACCAAGGCCAAG	13106	CUUGGCCUUGGUGAAGUGG

huGSKB-9	952	13096	CCUACAUCUGUUCUCGCUA	13107	UAGCGAGAACAGAUGUAGG

huGSKB-10	571	13097	UCCAGGACAAGAGGUUCAA	13108	UUGAACCUCUUGUCCUGGA

huGSKB-11	645	13098	AGAUACUUUUUCUACUCCA	13109	UGGAGUAGAAAAAGUAUCU

Human GSK beta duplexes correspond to the mouse GSK beta duplexes as follows:


	Mouse Duplex	Human Duplex

	AD-18833	huGSKB-1
	AD-18834	huGSKB-2
	AD-18835	huGSKB-3
	AD-18836	huGSKB-4
	AD-18837	huGSKB-5
	AD-18838	huGSKB-6
	AD-18839	huGSKB-7
	AD-18841	huGSKB-8
	AD-18842	huGSKB-9
	AD-18843	huGSKB-10
	AD-18844	huGSKB-11

Claims

1. A double-stranded ribonucleic acid (dsRNA), comprising a sense strand and an antisense strand, the sense strand comprising a first sequence and the antisense strand comprising a second sequence, the second sequence comprising a region complementary to an mRNA encoding a GSK-3, and wherein said region of complementarity is less than 30 nucleotides in length.

2. The dsRNA of claim 1, the second sequence comprising a region complementary to NM_—019884, NM_—00103166, :NM_—002093, or NM_—019827.

3-10. (canceled)

11. The dsRNA of claim 1, the sense strand comprising at least 15 nucleotides of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 and the antisense strand comprising at least 15 nucleotides of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.

12-15. (canceled)

16. The dsRNA of claim 1, wherein said dsRNA comprises at least one modified nucleotide.

17. The dsRNA of claim 16, wherein at least one of said modified nucleotides is chosen from the group of: a 2′-O-methyl modified nucleotide, a nucleotide comprising a 5′-phosphorothioate group, and a terminal nucleotide linked to a cholesteryl derivative or dodecanoic acid bisdecylamide group.

18. The dsRNA of claim 16, wherein said modified nucleotide is chosen from the group of: a 2′-deoxy-2′-fluoro modified nucleotide, a 2′-deoxy-modified nucleotide, a locked nucleotide, an abasic nucleotide, 2′-amino-modified nucleotide, 2′-alkyl-modified nucleotide, morpholino nucleotide, a phosphoramidate, and a non-natural base comprising nucleotide.

19. The dsRNA of claim 16, comprising at least one 2′-O-methyl modified nucleotide and at least one nucleotide comprising a 5′-phosphorothioate group.

20. The dsRNA of claim 1, wherein the region of complementary is at least 15 nucleotides in length.

21. The dsRNA of claim 1, wherein the region of complementarity is between 19 and 21 nucleotides in length.

22. The dsRNA of claim 1, wherein the region of complementarity is 19 nucleotides in length.

23. The dsRNA of claim 1, wherein administration of the dsRNA inhibits expression of GSK3 by more than 40%.

24. The dsRNA of claim 1, wherein the dsRNA exhibits an 1050 of less than or equal to 10 nM in suppressing GSK3.

25. The dsRNA of claim 1, wherein the dsRNA exhibits an 1050 of less than or equal to 1.0 nM in suppressing GSK3.

26. A cell comprising the dsRNA of claim 1.

27. A vector comprising at least one strand of the dsRNA of claim 1.

28. A cell comprising the vector of claim 27.

29. A pharmaceutical composition for inhibiting expression of an GSK-3 gene comprising the dsRNA of claim 1.

30. A method of inhibiting GSK-3 expression in a cell, the method comprising:

(a) introducing into the cell the dsRNA of claim 1; and

(b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of a GSK-3 gene, thereby inhibiting expression of a GSK-3 gene in the cell.

31. A method of treating a disorder mediated by GSK-3 expression comprising administering to a human in need of such treatment a therapeutically effective amount of the dsRNA of claim 1.

32. The method of claim 31, wherein the human has manic depression.