US20150366466A1 - Posture induced changes to physiological parameters - Google Patents
Posture induced changes to physiological parameters Download PDFInfo
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- US20150366466A1 US20150366466A1 US14/696,984 US201514696984A US2015366466A1 US 20150366466 A1 US20150366466 A1 US 20150366466A1 US 201514696984 A US201514696984 A US 201514696984A US 2015366466 A1 US2015366466 A1 US 2015366466A1
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- A61B5/024—Detecting, measuring or recording pulse rate or heart rate
- A61B5/02438—Detecting, measuring or recording pulse rate or heart rate with portable devices, e.g. worn by the patient
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Abstract
Methods and devices for analyzing posture-induced changes to physiological parameters of a patient (e.g., ejection time, heart rate, etc.) to provide an assessment of one or more conditions of the patient.
Description
- This application is a continuation of U.S. patent application Ser. No. 12/915,780, filed Oct. 29, 2010 entitled “POSTURE-INDUCED CHANGES TO PHYSIOLOGICAL PARAMETERS”, herein incorporated by reference in its entirety.
- The disclosure herein relates to methods for assessing one or more conditions of a patient using posture-induced changes to one or more heart-related physiological parameters, and further to devices for performing such assessment. For example, the disclosure herein includes methods and devices for monitoring and analyzing posture-induced changes to a patient's ejection time of the left or right ventricle and/or heart rate.
- One or more conditions of a patient may be determined by analyzing physiological parameters of a patient such as heart rate, respiration rate, and blood pressure, etc. These physiological parameters may be different for a healthy individual versus one who is unhealthy or suffering from an affliction.
- Further, such, physiological parameters may be affected by posture changes. For instance, a patient changing posture from a lying position to a more upright position may affect the patient's venous return due to gravity. As such, the patient's heart rate may increase to compensate for the hemodynamic effect due to gravity.
- Hypervolemia, elevated tissue pressure, and increased venomotor tone in heart failure patients often tend to minimize the hemodynamic effects due to gravity. Such conditions may also be present in patients before dialysis. After dialysis, the physiologic effects of gravity on the patient's heart may be restored.
- The disclosure herein relates to methods for assessing one or more conditions of a patient using posture-induced changes to one or more heart-related physiological parameters, and further to devices for performing such assessment. Such methods may include monitoring one or more physiological heart-related parameters, e.g., left and/or right ventricular ejection time, and analyzing the change to the physiological heart-related parameters from before the patient undergoes a posture change (or pre-posture change) to after the posture change (or post-posture change). The posture change may be a change in a patient's posture from a lying position to a position more upright than the lying position.
- One exemplary implantable medical device disclosed herein for use in assessment of one or more conditions of a patient may include sensing apparatus to monitor physiological parameters of the patient, a sensing module coupled to the sensing apparatus and configured to receive the monitored physiological parameters, and a control module coupled to the sensing module. The physiological parameters monitored by the sensing apparatus may include the patient's posture and ejection time. The patient's ejection time may include at least one of the patient's left ventricular ejection time and right ventricular ejection time.
- The control module may be configured to detect a change in the patient's posture from a lying position to an upright position using the monitored physiological parameters and to determine a posture-induced change to the patient's ejection time using the monitored physiological parameters. The posture-induced change to the patient's ejection time may include a difference between the patient's ejection time before the detected change in the patient's posture and the patient's ejection time after the detected change in the patient's posture. The control module may be further configured to store the posture-induced change to the patient's ejection time and analyze the posture-induced change to the patient's ejection time to provide an assessment of one or more conditions of the patient (e.g., fluid overload).
- In one or more embodiments of the exemplary methods and devices disclosed herein, the posture-induced change to the patient's ejection time may be a difference between the patient's average ejection time over a first plurality of heart beats before the detected change in the patient's posture and the patient's average ejection time over a second plurality of heart beats after the detected change in the patient's posture and/or a difference between the patient's average ejection time over a first predetermined period of time before the detected change in the patient's posture and the patient's average ejection time over a second predetermined period of time after the detected change in the patient's posture.
- Further, in one or more embodiments of the exemplary devices disclosed herein, the control module may be further configured to analyze the posture-induced change to the patient's ejection time by comparing the posture-induced change to the patient's ejection time to a baseline value and/or by comparing the posture-induced change to the patient's ejection time to a plurality of previous posture-induced changes to the patient's ejection time prior to the posture-induced change to the patient's ejection time to provide one or more trends to be used in the assessment of one or more conditions of the patient.
- Yet still further, in one or more embodiments of the exemplary devices disclosed herein, the exemplary devices further include at least one of a therapy delivery module coupled to the control module and a notification module coupled to the control module. The therapy delivery module may be configured to deliver cardiac therapy to the patient and the control module may be further configured to initiate or adjust cardiac therapy using the therapy delivery module based on the assessment of one or more conditions of the patient. The notification module may be configured to alert the patient and the control module may be further configured to initiate an alert using the notification module based on the assessment of one or more conditions of the patient.
- One exemplary method disclosed herein for use in assessment of one or more conditions of a patient may include monitoring physiological parameters of the patient. The physiological parameters may include the patient's posture and ejection time (e.g., at least one of the patient's left ventricular ejection time and right ventricular ejection time). The exemplary method may further include detecting a change in the patient's posture from a lying position to an upright position using the monitored physiological parameters and determining a posture-induced change to the patient's ejection time using the monitored physiological parameters. The posture-induced change to the patient's ejection time may be a difference between the patient's ejection time before the detected change in the patient's posture and the patient's ejection time after the detected change in the patient's posture. The exemplary method may further include storing the posture-induced change to the patient's ejection time and analyzing the posture-induced change to the patient's ejection time to provide an assessment of one or more conditions of the patient (e.g., fluid overload).
- In one or more embodiments of the exemplary methods described herein, analyzing the posture-induced change to the patient's ejection time may include comparing the posture-induced change to the patient's ejection time to a baseline value and/or comparing the posture-induced change to the patient's ejection time to a plurality of previous posture-induced changes to the patient's ejection time prior to the posture-induced change to the patient's ejection time to provide one or more trends to be used in the assessment of one or more conditions of the patient.
- Further, in one or more embodiments of the exemplary methods described herein, the exemplary methods include at least one of initiating or adjusting cardiac therapy to the patient based on the assessment of one or more conditions of the patient and/or alerting the patient based on the assessment of one or more conditions of the patient.
- In one or more embodiments of the exemplary methods described herein, analyzing the one or more trends in the plurality of posture-induced changes to the patient's ejection time over time may include determining whether the posture-induced changes to the patient's ejection time have been decreasing over time and providing an assessment that indicates that the patient's heart is progressing towards heart failure if the posture-induced changes to the patient's ejection time have been decreasing over time.
- Further, in one or more embodiments of the exemplary methods described herein, the exemplary methods may include determining a posture-induced change to the patient's heart rate using the monitored physiological parameters. The posture-induced change to the patient's heart rate may include a difference between the patient's heart rate before the detected change in the patient's posture and the patient's heart rate after the detected change in the patient's posture. The exemplary methods may further include storing the posture-induced change to the patient's heart rate and analyzing the posture-induced change to the patient's heart rate to verify the assessment of one or more conditions of the patient.
- Still further, in one or more embodiments of the exemplary methods described herein, analyzing one or more trends in the plurality of posture-induced changes to the patient's ejection time over time may include analyzing one or more trends in the plurality of posture-induced changes to the patient's ejection time that occur at the same time of the day.
- The above summary is not intended to describe each embodiment or every implementation of the present disclosure. A more complete understanding will become apparent and appreciated by referring to the following detailed description and claims taken in conjunction with the accompanying drawings.
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FIG. 1 is a diagram of an exemplary system including an exemplary implantable medical device (IMD). -
FIG. 2 is a diagram of the exemplary IMD ofFIG. 1 . -
FIG. 3 is a block diagram of an exemplary IMD, e.g., the IMD ofFIGS. 1-2 . -
FIG. 4 is a flow chart of an exemplary method for use in assessment of one or more conditions of a patient, e.g., using the IMDs ofFIGS. 1-3 . -
FIGS. 5A-5B are exemplary graphical depictions of posture-induced changes to a physiological parameter. -
FIG. 6 is an exemplary graphical depiction of posture-induced changes to a physiological parameter over a time period. - In the following detailed description of illustrative embodiments, reference is made to the accompanying figures of the drawing which form a part hereof, and in which are shown, by way of illustration, specific embodiments which may be practiced. It is to be understood that other embodiments may be utilized and structural changes may be made without departing from (e.g., still falling within) the scope of the disclosure presented hereby.
- Exemplary methods, devices, and systems shall be described with reference to
FIGS. 1-6 . It will be apparent to one skilled in the art that elements or processes from one embodiment may be used in combination with elements or processes of the other embodiments, and that the possible embodiments of such methods, devices, and systems using combinations of features set forth herein is not limited to the specific embodiments shown in the Figures and/or described herein. Further, it will be recognized that the embodiments described herein may include many elements that are not necessarily shown to scale. Still further, it will be recognized that timing of the processes and the size and shape of various elements herein may be modified but still fall within the scope of the present disclosure, although certain timings, one or more shapes and/or sizes, or types of elements, may be advantageous over others. -
FIG. 1 is a conceptual diagram illustrating anexemplary therapy system 10 that may be used in assessment of one or more conditions of apatient 14.Patient 12 may, but not necessarily, be a human. Thetherapy system 10 may include an implantable medical device 16 (IMD), which may be coupled to leads 18, 20, 22 and aprogrammer 24. The IMD 16 may be, e.g., an implantable pacemaker, cardioverter, and/or defibrillator, that provides electrical signals to theheart 12 of thepatient 14 via electrodes coupled to one or more of theleads - The leads 18, 20, 22 extend into the
heart 12 of thepatient 14 to sense electrical activity of theheart 12 and/or deliver electrical stimulation to theheart 12. In the example shown inFIG. 1 , the right ventricular (RV)lead 18 extends through one or more veins (not shown), the superior vena cava (not shown), and theright atrium 26, and into theright ventricle 28. The left ventricular (LV)coronary sinus lead 20 extends through one or more veins, the vena cava, theright atrium 26, and into thecoronary sinus 30 to a region adjacent to the free wall of theleft ventricle 32 of theheart 12. The right atrial (RA) lead 22 extends through one or more veins and the vena cava, and into theright atrium 26 of theheart 12. - The
IMD 16 may sense, among other things, electrical signals attendant to the depolarization and repolarization of theheart 12 via electrodes (not shown inFIG. 1 ) coupled to at least one of theleads IMD 16 provides pacing pulses to theheart 12 based on the electrical signals sensed within theheart 12. The configurations of electrodes used by theIMD 16 for sensing and pacing may be unipolar or bipolar. TheIMD 16 may also provide defibrillation therapy and/or cardioversion therapy via electrodes located on at least one of theleads IMD 16 may detect arrhythmia of theheart 12, such as fibrillation of theventricles heart 12 in the form of electrical pulses. - In some examples, the
programmer 24 may be a handheld computing device or a computer workstation, which a user, such as a physician, technician, other clinician, and/or patient may use to communicate with theIMD 16. For example, the user may interact with theprogrammer 24 to retrieve physiological and/or diagnostic information (e.g., posture-induced changes to one or more physiological parameters, assessments of one or more conditions of thepatient 14, etc.) from theIMD 16. - The
IMD 16 and theprogrammer 24 may communicate via wireless communication using any techniques known in the art. Examples of communication techniques may include, e.g., low frequency or radiofrequency (RF) telemetry, but other techniques are also contemplated. -
FIG. 2 is a conceptual diagram illustrating theIMD 16 and theleads therapy system 10 ofFIG. 1 in more detail. The leads 18, 20, 22 may be electrically coupled to a therapy delivery module, a sensing module, and/or any other modules of theIMD 16 via aconnector block 34. In some examples, the proximal ends of theleads connector block 34 of theIMD 16. In addition, in some examples, theleads connector block 34 with the aid of set screws, connection pins, or another suitable mechanical coupling mechanism. - Each of the
leads pressure sensor 38 andbipolar electrodes lead 18. In addition, thebipolar electrodes lead 20 and thebipolar electrodes lead 22. As shown inFIG. 2 , thepressure sensor 38 is disposed in theright ventricle 28 of the patient'sheart 12. Thepressure sensor 38 may respond to an absolute pressure inside theright ventricle 28, and may be, e.g., a capacitive and/or piezoelectric pressure sensor. In other examples, thepressure sensor 38 may be positioned within other regions of the heart 12 (e.g., the left ventricle) and may monitor pressure within one or more of the other regions of theheart 12, or may be positioned elsewhere within or proximate to the cardiovascular system of the patient 14 to monitor cardiovascular pressure associated with mechanical contraction of the heart. - The
electrodes electrodes electrodes lead leads - The
electrodes heart 12. The electrical signals are conducted to theIMD 16 via the respective leads 18, 20, 22. In some examples, theIMD 16 may also deliver pacing pulses via theelectrodes heart 12. In some examples, as illustrated inFIG. 2 , theIMD 16 includes one or more housing electrodes, such ashousing electrode 58, which may be formed integrally with an outer surface of a housing 60 (e.g., hermetically-sealed housing) of theIMD 16 or otherwise coupled to thehousing 60. - The leads 18, 20, 22 may also include
elongated electrodes IMD 16 may deliver defibrillation shocks to theheart 12 via any combination of theelongated electrodes housing electrode 58. Theelectrodes heart 12. Further, theelectrodes - The
pressure sensor 38 may be coupled to one or more coiled conductors within thelead 18. InFIG. 2 , thepressure sensor 38 is located more distally on thelead 18 than theelongated electrode 62. In other examples, thepressure sensor 38 may be positioned more proximally than theelongated electrode 62, rather than distal to theelectrode 62. Further, thepressure sensor 38 may be coupled to another one of theleads leads pressure sensor 38 may be self-contained device that is implanted within theheart 12, such as within the septum separating theright ventricle 28 from theleft ventricle 32, or the septum separating theright atrium 26 from theleft atrium 33. In such an example, thepressure sensor 38 may wirelessly communicate with a sensing module of theIMD 16. - The configuration of the
therapy system 10 illustrated inFIGS. 1-2 is merely one example. In other examples, a therapy system may include epicardial leads and/or patch electrodes instead of or in addition to the transvenous leads 18, 20, 22 illustrated inFIG. 1 . Further, in one or more embodiments, theIMD 16 need not be implanted within thepatient 14. For example, theIMD 16 may deliver defibrillation shocks and other therapies to theheart 12 via percutaneous leads that extend through the skin of the patient 14 to a variety of positions within or outside of theheart 12. - In other examples of therapy systems that provide electrical stimulation therapy to the
heart 12, a therapy system may include any suitable number of leads coupled to theIMD 16, and each of the leads may extend to any location within or proximate to theheart 12. For example, other examples of therapy systems may include three transvenous leads located as illustrated inFIGS. 1-2 , and an additional lead located within or proximate to theleft atrium 33. Still further, other therapy systems may include a single lead that extends from theIMD 16 into theright atrium 26 or theright ventricle 28, or two leads that extend into a respective one of theright ventricle 26 and theright atrium 28. -
FIG. 3 is a functional block diagram of one example configuration ofIMD 16. As shown, theIMD 16 may include acontrol module 81, a therapy delivery module 84 (e.g., a stimulation generator), asensing module 86, and apower source 90. - The
control module 81 may include aprocessor 80,memory 82, and atelemetry module 88. Thememory 82 may include computer-readable instructions that, when executed, e.g., by theprocessor 80, cause theIMD 16 and thecontrol module 81 to perform various functions attributed to theIMD 16 and thecontrol module 81 described herein. Further, thememory 82 may include any volatile, non-volatile, magnetic, optical, or electrical media, such as a random access memory (RAM), read-only memory (ROM), non-volatile RAM (NVRAM), electrically-erasable programmable ROM (EEPROM), flash memory, or any other digital media. - The
processor 80 of thecontrol module 81 may include any one or more of a microprocessor, a controller, a digital signal processor (DSP), an application specific integrated circuit (ASIC), a field-programmable gate array (FPGA), or equivalent discrete or integrated logic circuitry. In some examples, theprocessor 80 may include multiple components, such as any combination of one or more microprocessors, one or more controllers, one or more DSPs, one or more ASICs, or one or more FPGAs, as well as other discrete or integrated logic circuitry. The functions attributed to theprocessor 80 herein may be embodied as software, firmware, hardware, or any combination thereof. - The
control module 81 controls thetherapy delivery module 84 to deliver therapy (e.g., electrical stimulation therapy) to theheart 12 according to a selected one or more of therapy programs, which may be stored in thememory 82. Specifically, theprocessor 80 of thecontrol module 81 may control thetherapy delivery module 84 to deliver electrical pulses with the amplitudes, pulse widths, frequency, and/or electrode polarities specified by the selected one or more therapy programs. - Although not shown, the
IMD 16 may further include a notification module that is configured to provide an alert (e.g., to the patient, a clinician, and/or hospital), such as an audio, somatosensory, visual alert, and/or telemetry to an external data collection server. In some cases, theIMD 16 may send the alert to another device, such as theprogrammer 24, either automatically or upon request. In at least one embodiment, thecontrol module 81 is configured to initiate an alert using the notification module based on an assessment of one or more conditions of the patient. - The
therapy delivery module 84 is coupled (e.g., electrically coupled) totherapy delivery apparatus 85. The therapy deliverapparatus 85 may include, among other therapy delivery devices, theelectrodes FIGS. 1-2 (e.g., via conductors of the respective leads 18, 20, 22) and/or thehousing electrode 58. Thetherapy delivery module 84 may be configured to generate and deliver electrical stimulation therapy to theheart 12. For example, the therapy delivermodule 84 may deliver defibrillation shocks to theheart 12 via at least two of the plurality of electrodes, e.g.,electrodes therapy delivery module 84 may deliver pacing pulses via thering electrodes leads helical electrodes leads therapy delivery module 84 delivers pacing, cardioversion, and/or defibrillation stimulation in the form of electrical pulses. - The
sensing module 86 is coupled (e.g., electrically coupled) tosensing apparatus 87, e.g., to monitors signals from thesensing apparatus 87. Thesensing apparatus 87 may include theelectrodes heart 12, e.g., impedance signals between two or more electrodes (e.g., right and/or left ventricle impedance, subcutaneous impedance, impedance waveform during ejection, impedance waveform during filling, etc.), electrocardiogram (ECG) signals, etc. The impedance signals may be used to monitor stroke volume (SV), ejection time (ET), etc. The ECG signals may be used to monitor heart rate (HR), heart rate variability (HRV), heart rate turbulence (HRT), deceleration/acceleration capacity, deceleration sequence incidence, T-wave alternans (TWA), P-wave to P-wave intervals (also referred to as the P-P intervals or A-A intervals), R-wave to R-wave intervals (also referred to as the R-R intervals or V-V intervals), P-wave to QRS complex intervals (also referred to as the P-R intervals, A-V intervals, or P-Q intervals), QRS-complex morphology, ST segment (i.e., the segment that connects the QRS complex and the T-wave), T-wave changes, QT intervals, electrical vectors, etc. Thesensing apparatus 87 may further include one or more pressure sensors, posture sensors (e.g., 2-D and/or 3-D accelerometers), heart sound sensors, activity sensors, perfusion sensors, etc. to monitor one or more heart-related physiological parameters such as, e.g., patient posture, ejection time, stroke volume, cardiac output, pre-ejection time, filling time, normalized ejection time % (ejection time divided by the R-R interval expressed as a percentage), etc. - The one or more posture sensors of the
sensing apparatus 87 may provide signals or values corresponding to the posture of thepatient 14, the activity level of thepatient 14, etc. Using such signals or values, the IMD 16 (e.g., the control module 81) may determine whether thepatient 14 has made a change in posture. For example, theIMD 16 may use one or more accelerometers to detect changes in the patient's posture from a lying position to an upright position or from an upright position to a lying position. As used herein, a lying position may be any position in which the patient's torso is less than completely vertical (e.g., perpendicular to a flat ground surface). In other words, a patient's torso may be less than completely vertical when it forms less than a 90 degree angle with the ground surface. The lying position may be include supine, prone, right lateral decubitus (e.g., the patient lying on their right side), and left lateral decubitus (e.g., the patient lying on their left side) positions. Further, the patient may be in a lying position while resting in a reclined chair (e.g., having their torso forming less than a 90 degree angle with the ground surface). - Further, as used herein, an upright position may be simply a more upright position than the patient's lying position. For example, if the patient's lying position is resting in a recliner with their torso at a 45 degree angle (e.g., to the ground surface), an upright position may be sitting with their torso at a 70 degree angle. Further, for example, the upright position may simply be a standing posture (e.g., the patient standing on their two feet on a ground surface or floor such that they are substantially vertical).
- One example of a posture sensor capable of detecting patient posture, motion, and activity is an accelerometer, such as a multi-axis accelerometer. A three-axis accelerometer, e.g., may be able to detect motion and posture by detecting acceleration along three axes. An exemplary accelerometer that may be used with the methods and devices disclosure herein may be described in U.S. Pat. No. 5,425,750 to Moberg, which is incorporated by reference in its entirety.
- The
sensing apparatus 87 is further capable to measure and/or monitor the ejection time of the right and/or left ventricle. For example, thesensing apparatus 87 may utilize two or more electrodes and/or one or more pressure sensors (e.g., pressure sensors 38) located within the right and/or left ventricle to measure and/or monitor the ejection time of the right and/or left ventricle. Further, thecontrol module 81 may use the data collected using thesensing apparatus 87 to calculate the ejection time of the right and/or left ventricle. - With respect to the electrodes, the
sensing module 86 may also include a switch module to select which of the available electrodes are used to sense heart activity. In some examples, thecontrol module 81 may select the electrodes that function as sensing electrodes via the switch module within thesensing module 86, e.g., by providing signals via a data/address bus. In some examples, thesensing module 86 may include one or more sensing channels, each of which may include an amplifier. In response to the signals from thecontrol module 81, the switch module of thesensing module 86 may couple the outputs from the selected electrodes to one or more of the sensing channels. - The
telemetry module 88 of thecontrol module 81 may include any suitable hardware, firmware, software, or any combination thereof for communicating with another device, such as the programmer 24 (FIG. 1 ). For example, under the control of theprocessor 80, thetelemetry module 88 may receive downlink telemetry from and send uplink telemetry to theprogrammer 24 with the aid of an antenna, which may be internal and/or external. Theprocessor 80 may provide the data to be uplinked to theprogrammer 24 and the control signals for the telemetry circuit within thetelemetry module 88, e.g., via an address/data bus. In some examples, thetelemetry module 88 may provide received data to theprocessor 80 via a multiplexer. - The various components of the
IMD 16 are further coupled to apower source 90, which may include a rechargeable or non-rechargeable battery. A non-rechargeable battery may be selected to last for several years, while a rechargeable battery may be inductively charged from an external device, e.g., on a daily or weekly basis. - Further, although the
IMD 16 as described herein may include a therapy delivery module coupled 84 andtherapy delivery apparatus 85, and may be used to deliver therapy (e.g., in view of an assessment of one or more conditions) using such items, in one or more embodiments, theIMD 16 and/or any other device may utilize the methods and/or techniques described herein without delivering therapy. For example, an exemplary device may not include a therapy delivermodule 84 and/ortherapy delivery apparatus 85 and, as such, may not deliver therapy, but such exemplary device may still be configured to assess one or more conditions of a patient using posture-induced changes to one or more heart-related physiological parameters. - As described herein, a patient changing posture from a lying position to a more upright position may affect the patient's venous return due to gravity, and as a result, the patient's stroke volume and/or ejection time may decrease and heart rate may increase to compensate for the hemodynamic effect due to gravity. One or more conditions (e.g., congestive heart failure, fluid overload, etc.) may inhibit the hemodynamic effects of one or more physiological parameters due to gravity.
- Stroke volume may be estimated through the measurement of ejection time. For instance, stroke volume and ejection time may be substantially linearly related (e.g., as stroke volume increases, ejection time increases and vice versa). As described herein, ejection time may be measured using right ventricular pressure, right ventricular impedance, heart sounds, subcutaneous impedance, subcutaneous perfusion, etc. For example, an impedance waveform may be monitored using an RV lead immediately after RV pacing or a sensed RV activity (e.g., R-wave, contraction, etc.) for at least 300 milliseconds (ms). The start of ejection time can be determined through the morphologic analysis of the impedance waveform within a first time window of 150 ms starting from RV pacing or a sensed RV activity. The end of ejection time can be determined through the morphologic analysis of the impedance waveform within a second time window of 150 ms centered on T-wave sensing. Further, for example, the impedance waveform may simply be monitored in a time window of about 350 ms from RV pacing or a sensed RV activity to determine ejection time. Still further, for example, detection of the first heart sound (FHS), an indicator of the onset of the ejection, and the second heart sound (SHS), an indicator of the offset of ejection, may be used to determine ejection time. Although described separately, each of these exemplary techniques may be used alone or in combination for a more precise estimation of ejection time. Further, right ventricular ejection time and left ventricular ejection time may have parallel trends, and as such, either or both of them may be used to estimate stroke volume.
- A
generalized method 200 for use in assessment of one or more conditions of a patient's heart is diagrammatically depicted inFIG. 4 .Method 200 is intended to illustrate the general functional operation of the devices and/or systems described herein, and should not be construed as reflective of a specific form of software or hardware necessary to practice all of the methods described herein. It is believed that the particular form of software will be determined primarily by the particular system architecture employed in the device (e.g., IMD 16) and by the particular detection and therapy delivery methodologies employed by the device and/or system. Providing software and/or hardware to accomplish the described methods in the context of any modern IMD, given the disclosure herein, is within the abilities of one of skill in the art. - The
method 200 ofFIG. 4 includesdata collection 202.Data collection 202 may include monitoring one or more physiological parameters of a patient (e.g., at least one physiological parameter) such as, for example, the patient's posture, the electrical activity of the patient's heart, the ejection time of the patients' left and/or right ventricle, etc. - The data collected 202 may be analyzed to detect and/or determine a change in the patient's
posture 204. For example, the monitored physiological parameters with respect to a patient's posture may indicate that the patient has moved from a lying position to an upright position, from an upright position to a lying position, from a lying position to a more upright position, from an upright position to a less upright position, from a sitting position to a standing position, from a standing position to a sitting position, from a reclined sitting/laying position to a less reclined sitting/laying position, from a reclined sitting/laying position to a more reclined sitting/laying position, etc. - Although an arrow is shown in
FIG. 4 extending fromdata collection 202 to posture change detection/determination 204, thedata collection 202 and the posture change detection/determination 204, as well as other processes described herein, may be executed concurrently as opposed to sequentially or periodically. - If a posture change is detected 204 (e.g., if the physiological parameters of the patient indicate that the patient's posture has changed), the
method 200 proceeds to determine the posture-induced changes to one or more physiological parameters of the patient 206., e.g., changes to the patient's ejection time, changes to the patient's heart rate, etc., due, in part, to the posture change. In at least one embodiment, the change to the patient's ejection time may be the difference or variation between the patient's ejection time before the change in the patient's posture and the patient's ejection time after the change in the patient's posture. In at least another embodiment, the change to the patient's heart rate may be the difference or variation between the patient's heart rate before the change in the patient's posture and the patient's heart rate after the change in the patient's posture. In other words, a posture-induced change to a physiological parameter may simply be the difference or variation between a physiological parameter pre-posture change to post-posture change. Such posture-induced change to a physiological parameter may be represented as a percentage of change from the value of the physiological parameter prior to the posture change. - For example, as shown in
FIGS. 5A-5B , aphysiological parameter 232 of a patient is plotted over a time period within which aposture change 238 occurs. Thephysiological parameter 232 depicted inFIG. 5A is of a healthy patient while thephysiological parameter 232 depicted inFIG. 5B is of an unhealthy patient (e.g., a patient progressing towards heart failure, a patient that is undergoing fluid overload, etc.). - During the
time period 234 prior to theposture change 238, thephysiological parameter 232 may be at a first value or level. During thetime period 236 after theposture change 238, thephysiological parameter 232 may be at a different or second value or level. In one embodiment, the posture-induced physiological parameter may be thedifference time period 234 prior to the posture change 238) from the second value of the physiological parameter 232 (i.e., from thetime period 236 after to the posture change 238). - Although, as depicted, the physiological parameter 232 (e.g., ejection time, stroke volume, etc.) decreases after the
posture change 238, thephysiological parameter 232 may actually increase, e.g., depending on thephysiological parameter 232 being monitored. For example, a posture change from a lying position to an upright position should induce an increase in a patient's heart rate. Also, the opposite behavior may be observed during the opposite posture change, e.g., from an upright position to a lying position. For example, a posture change from an upright position to a lying position should induce an increase in the ejection time/stroke volume of a patient's heart and a decrease in the patient's heart rate. - The posture-induced changes to ejection time, heart rate, and/or any other of the one or more physiological parameters may be sampled for a period before and after the posture change. For example, the posture-induced change may be a difference between the average of the physiological parameter over a first selected plurality of heart beats (e.g., more or less than 4 beats, more or less than 8 beats, more or less than 16 beats, more or less than 32 beats, and/or more or less than 64 beats) before the detected change in the patient's posture and the average of the physiological parameter over a second selected plurality of heart beats (e.g., more or less than 4 beats, more or less than 8 beats, more or less than 16 beats, more or less than 32 beats, and/or more or less than 64 beats) after the detected change in the patient's posture. In at least one embodiment, the posture-induced change to one or more physiological parameters of a patient may be a difference between the patient's average ejection time over a first plurality of heart beats (e.g., about 4 beats to about 64 beats) before the detected change in the patient's posture and the patient's average ejection time over a second plurality of heart beats (e.g., about 4 beats to about 64 beats) after the detected change in the patient's posture.
- Further, for example, the posture-induced change may be a difference between the average of the physiological parameter over a first predetermined period of time (e.g., more or less than 60 seconds, more or less than 30 seconds, more or less than 20 seconds, more or less than 10 seconds, and/or more or less than 5 seconds) before the detected change in the patient's posture and the average of the physiological parameter over a second predetermined period of time (e.g., more or less than 60 seconds, more or less than 30 seconds, more or less than 20 seconds, more or less than 10 seconds, and/or more or less than 5 seconds) after the detected change in the patient's posture. In at least one embodiment, the posture-induced change to one or more physiological parameters of a patient may be a difference between the patient's average ejection time over a first predetermined period of time (e.g., about 5 seconds to about 60 seconds) before the detected change in the patient's posture and the patient's average ejection time over a second predetermined period of time (e.g., about 5 seconds to about 60 seconds) after the detected change in the patient's posture.
- As described herein, one of the physiological parameters that may be monitored for a posture-induced change is the left and/or right ventricular ejection time. The posture-induced changes to left and/or right ventricular ejection time may be indicative (e.g., a marker) of fluid overload because, e.g., variations in ejection time during postural changes may decrease as fluid overload increases and may be restored to a normal value when fluid balance has been restored.
- After determining the posture-induced
change 206, themethod 200 proceeds to store the posture-induced change 208 (e.g., in thememory 81 of the IMD 16) and analyze the posture-induced change to provide an assessment of one or more conditions of apatient heart 210. - As shown, e.g., in
FIGS. 5A-5B , the difference 240 (e.g., the magnitude or absolute value) of thephysiological parameter 232 of the healthy patient is greater than thedifference 242 of the unhealthy patient. As such, the magnitude or absolute value of the difference between a physiological parameter monitored before a posture change and after a posture change may be indicative of one or more conditions of a patient (e.g., fluid overload, heart failure). In other words, the magnitude or absolute value of the difference of a physiological parameter pre-posture change to post-posture change may be indicative of one or more conditions of a patient. Such difference may be referred to as a posture-induced change to a physiological parameter. The posture-induced change may then be compared, e.g., to a min/max limit, baseline values, historical values, pre-set values, etc., to determine whether the posture-induced change may indicate one or more conditions of a patient. In at least one embodiment, the posture-induced change may be calculated, stored, and/or used as a percentage difference, e.g., the absolute value of the pre-posture change value subtracted from the post-posture change value, then divided by the pre-posture change value, and provided as a percentage. - For example, the ejection time of the left and/or right ventricle of a patient may be monitored and posture-induced changes to the patient's ejection time may be determined and compared to a baseline value (e.g., selected by a clinician, automatically calculated by an IMD itself, etc). The baseline value may be the an acceptable percentage difference between an acceptable value representative of the physiological parameter prior to the posture change, and an acceptable value representative of the physiological parameter after the posture change. In other words, the baseline value may be the percentage change in the physiological parameter from pre-posture change to post-posture change that may be indicative of a healthy patient.
- In at least one embodiment, if a posture-induced change to ejection time or heart rate, calculated as a percentage difference relative to a pre-posture change level, is greater than about a 20 percent change (or, e.g., greater than about a 5 percent change, greater than about a 10 percent change, greater than about a 15 percent change, or greater than about a 25 percent change), it may indicate that the patient is healthy. In other words, for example, in a normal healthy patient, without fluid overload, the amount of change in ejection time or heart rate due to the posture change should not be decreased (e.g., it is still greater than a 20 percent change just as it should be in a healthy patient). Likewise, if a posture-induced change to ejection time or heart rate, also calculated as a percentage difference relative to a pre-posture change level, is less than about a 20 percent change (or, e.g., less than about a 5 percent change, less than about a 10 percent change, less than about a 15 percent change, or less than about a 25 percent change), it may indicate that the patient is unhealthy (e.g., the patient is at risk for heart failure, the patient may be undergoing fluid overload to at least some degree, etc.). In other words, the fluid overload decreases the amount of change (e.g., an unhealthy patient may have a less than about a 10 percent change due to the particular posture change) when that particular change in posture should be causing a larger change in the physiological parameter (e.g., the person when healthy would have a change greater than 20 percent). As such, an indication of fluid overload is indicated.
- As such, the
analysis 210 may include comparing the determined posture-induced changes to one or more of the physiological parameters of the patient to a selected value (e.g., a baseline percentage of change, such as when the person is healthy). In at least one embodiment, the selected value may be established as being indicative of healthy heart function in response to posture changes (and, in turn, gravity effects). For example, as described herein, a posture-induced change to the patient's ejection time (e.g., the absolute vale of the pre-posture change value subtracted from the post-posture change value, divided by the pre-posture change value, and provided in percentage form) less than a 10 percent change may indicate heart failure and/or is in a fluid overload condition. As such, if the posture-induced change to a patient's ejection time is less than 10 percent, then the analysis may provide an assessment that indicates that the patient is at risk of heart failure and/or fluid overload. - Further, the
analysis 210 may include comparing a present posture-induced change of one or more physiological parameters of the patient (e.g., a currently detected change, such as the most recently detected change) to a plurality of previous posture-induced changes of the one or more physiological parameters of the patient detected prior to the present posture-induced change. For example, a plurality of posture-induced changes may have been stored 208 over a selected time period, and an average of the plurality of posture-induced changes may establish an acceptable baseline value to compare with the present posture-induced change. However, the present posture-induced change to the physiological parameter detected by the system may be compared to any suitable limit (e.g., max/min), and such comparison is not limited to only a baseline determined based on prior detected measurements. For example, such limits may be limits based on test data from a plurality of patients or limits based on test data from the same patient. - Although analyzing a single posture-induced change may provide an assessment of one or more conditions of a patient (e.g., by comparison to a baseline or other threshold limit), the trend of posture-induced changes to one or more physiological parameters of a patient over time may also provide further assessment of one or more conditions of the patient. For example, the
analysis 210 may include analyzing a trend in a plurality of posture-induced changes to one or more physiological parameters of a patient (e.g., right and/or left ejection time, heart rate, etc.) over time, or, in other words, determining a trend in the data through such analysis. - A plurality of posture-induced changes to
ejection time 272 of a patient over time are depicted inFIG. 6 . Thex-axis 274 represents time in days. As shown, the posture-induced changes toejection time 272 decrease, or trend downwardly, afterday 1 untilday 5, at which time an acute exacerbation ofheart failure 282 occurs. Afterwards, the posture-induced changes toejection time 272 increase or trend upwardly. In other words, prior to the acute exacerbation ofheart failure 282, the patient may have progressed 280 towards fluid overload and/or heart failure, e.g., as correlated with the downward trend of the posture-induced changes toejection time 272. In other words, for example, due to fluid overload, the change in ejection time caused by a particular type of posture change (e.g., transitioning from a lying state to a more upright position) decreased each day for several days. After theacute exacerbation 282, the patient progressed towards recovery, e.g., as correlated with the upward trend of the posture-induced changes toejection time 272. - As such, one or more trends of posture-induced changes to one or more physiological parameters of a patient (e.g., a pattern in a plurality of posture-induced changes over time, such as changes occurring for the same posture change such as from the same lying position to the same upright position) may be useful to analyze to provide an assessment of one or more conditions of a patient. In at least one embodiment, the
analysis 210 may include determining whether the posture-induced changes to one or more of the physiological parameters of the patient (e.g., ejection time) have been increasing, decreasing, or constant over time. For example, if the trend of posture-induced changes to the patient's ejection time and/or heart rate has been decreasing, the assessment provided by the analysis may indicate a progression towards fluid overload and/or heart failure. Further, for example, if the trend of posture-induced changes to the patient's ejection time and/or heart rate has been constant, the assessment provided by the analysis may indicate that the patient is healthy. - A trend that indicates that one or more conditions of a patient are worsening may trigger or initiate additional monitoring of the patient. In at least one embodiment, the methods and/or devices described herein may include an extra verification or validation process to confirm the findings indicated by a trend that indicates that one or more conditions of the patient are worsening. For example, if the posture-induced changes to one or more physiological parameters indicate that one or more conditions of the patient are worsening (e.g., the trend in posture-induced changes to the patient's ejection time shows a decrease), then analysis of posture-induced changes to one or more physiological parameters (e.g., the patient's heart rate) may be used to verify the assessment of one or more conditions of the patient. In at least one embodiment, the posture-induced changes to the patient's heart rate may be compared to a baseline value to confirm, validate, or verify a finding (e.g., based on ejection time changes) that one or more conditions of the patient are worsening.
- In at least another embodiment, if the posture-induced changes to one or more physiological parameters indicate that one or more conditions of the patient are worsening (e.g., the trend in posture-induced changes to the patient's ejection shows a decrease), then the methods and/or devices described herein may increase the monitoring of one or more parameters associated with one or more conditions of the patient. For example, the frequency at which various parameters may be monitored may be increased beyond normal operating parameters (e.g., instead of monitoring various physiological parameters once a day, the devices and/or methods may monitor various physiological parameters multiple times a day). Further, for example, additional monitoring may be triggered or initiated that may not normally occur.
- Further, the posture-induced changes to one or more physiological parameters of a patient may fluctuate depending on multiple factors such as, e.g., the specific type of posture change, the time of day, the excitement and/or activity level of the patient, etc. As such, an analysis of a single posture-induced change or a trend of posture-induced changes to one or more physiological parameters of a patient may take into consideration such factors, such as the specific type of posture change. For example, a posture-induced change to a physiological parameter, e.g., ejection time, in response to a patient moving from a horizontal, lying position to a vertical, standing upright position may be different than a posture-induced change in response to the same patient moving from a sitting position to a vertical, standing upright position.
- Further, for example, a posture-induced change to a physiological parameter, e.g., ejection time, that occurs immediately after a patient wakes up (e.g., getting out of bed) when the patient's activity level is low may be different than a posture-induced change that occurs later in the day after the patient's activity level may have been elevated.
- As such, the methods described herein may take into consideration one or more of the factors that may affect the posture-induced changes to one or more physiological parameters (e.g., such as the particular type of posture change, the time of day, etc.) such that the analysis of posture-induced changes may be more predictable and/or consistent. More specifically, the methods may only record/store, analyze, and/or compare posture-induced changes (e.g., compared to base line values, within a trend, compared to each other, etc.) that occur in the same or similar circumstances and/or factors.
- For example, in at least one embodiment, the posture-induced changes to one or more physiological parameters of a patient that are to be used in analysis may be only collected at the same time of the day, e.g., once a day in the morning after the patient wakes up and makes their first posture change from a lying position to a more upright position. Further, for example, the posture-induced changes to one or more physiological parameters of a patient may be collected in the afternoon (after rest) or at night when a patient makes a posture change from an upright position to lying position. Although described separately, in at least one embodiment, the posture-induced changes collected in the morning, evening, or afternoon may be analyzed in conjunction with one another (e.g., the absolute values of posture-induced changes may be similar).
- As described, one of the factors that may affect the posture-induced changes to one or more physiological parameters is the specific type of posture change. As a result, the methods and devices described herein may only store/record, analyze, and/or compare postured-induced changes to physiological parameters that correspond to the same specific type of posture change. For example, only posture-induced changes to one or more physiological parameters induced by posture changes from a horizontal, lying position to a vertical, upright position may be monitored and analyzed.
- Further, physiological parameter data may be collected for a plurality of postures, e.g., lying positions and upright positions, and such data may be compared to each other to establish baseline values (of one or more physiological parameters) for a plurality of posture changes. In other words, the methods described herein may determine what lying and upright positions are common enough to provide reliable trends. For example, posture-induced changes to one or more physiological parameters of a patient may be monitored for a selected period of time (e.g., over the course of a week) and baselines values (of a posture-induced changes) may be established for each, specific common lying position and each, specific upright position. In effect, baseline values may be established for a plurality of posture changes, each posture change being a different combination of common lying positions and common upright positions (e.g., by subtracting the baseline values for each specific common lying position and each specific upright position). As a result, each of the plurality of posture changes may have specific baseline values for use in analysis.
- As depicted in
FIG. 4 , themethod 200 may return todata collection 202 or proceed to provide an alert 212 and/or deliver/adjusttherapy 214. If it is determined that the posture-induced changes may indicate that the patient is not healthy, themethod 200 may return todata collection 202. If it is determined that the posture-induced changes indicate that the patient is unhealthy, then themethod 200 may provide an alert 212 and/or deliver/adjusttherapy 214. After the alert has been provided 212, and/or cardiac therapy has been delivered/adjusted 214, themethod 200 may return todata collection 202. - Providing an alert 212 may include delivering an alert to the patient or a caregiver. The alert may include one or more of an audible signal, a text message, and/or some other signal to draw attention to the patient's worsening condition. For example, the alert may be wirelessly transmitted to the
programmer 24. Further, in one or more embodiments, the alert may be transmitted to an external device that is connected to the Internet such that the alert may also be transmitted to a clinician overseeing the patient. - The
method 200 may utilize one or more therapies (e.g., cardiac therapy, fluid removal therapies, medication, drug delivery therapy, etc.) to the patient described herein. Depending on the assessment of the one or more conditions of the patient, such therapies may be delivered and/or adjusted 214 to treat the one or more conditions. For example, if theassessment 210 indicates that the patient is likely undergoing fluid overload that may lead to heart failure, themethod 200 may deliver pacing therapy to the patient's heart, therapy to remove fluid, etc. Further, for example, if theassessment 210 indicates that the patient is likely undergoing fluid overload that may lead to heart failure and the patient's heart rate is less than 70 beats per minute, the rate at which the patient's heart is being paced may be increased to 80 beats per minute to increase the cardiac output to, e.g., facilitate fluid removal. - The techniques described in this disclosure, including those attributed to the
IMD 16, theprogrammer 24, or various constituent components, may be implemented, at least in part, in hardware, software, firmware, or any combination thereof. For example, various aspects of the techniques may be implemented within one or more processors, including one or more microprocessors, DSPs, ASICs, FPGAs, or any other equivalent integrated or discrete logic circuitry, as well as any combinations of such components, embodied in programmers, such as physician or patient programmers, stimulators, image processing devices, or other devices. The term “module,” “processor,” or “processing circuitry” may generally refer to any of the foregoing logic circuitry, alone or in combination with other logic circuitry, or any other equivalent circuitry. - Such hardware, software, and/or firmware may be implemented within the same device or within separate devices to support the various operations and functions described in this disclosure. In addition, any of the described units, modules, or components may be implemented together or separately as discrete but interoperable logic devices. Depiction of different features as modules or units is intended to highlight different functional aspects and does not necessarily imply that such modules or units must be realized by separate hardware or software components. Rather, functionality associated with one or more modules or units may be performed by separate hardware or software components, or integrated within common or separate hardware or software components.
- When implemented in software, the functionality ascribed to the systems, devices and techniques described in this disclosure may be embodied as instructions on a computer-readable medium such as RAM, ROM, NVRAM, EEPROM, FLASH memory, magnetic data storage media, optical data storage media, or the like. The instructions may be executed by one or more processors to support one or more aspects of the functionality described in this disclosure.
- All patents, patent documents, and references cited herein are incorporated in their entirety as if each were incorporated separately. This disclosure has been provided with reference to illustrative embodiments and is not meant to be construed in a limiting sense. As described previously, one skilled in the art will recognize that other various illustrative applications may use the techniques as described herein to take advantage of the beneficial characteristics of the apparatus and methods described herein. Various modifications of the illustrative embodiments, as well as additional embodiments of the disclosure, will be apparent upon reference to this description.
Claims (22)
1. An implantable medical device for use in assessment of one or more conditions of a patient comprising:
sensing apparatus to monitor physiological parameters of the patient, wherein the physiological parameters comprise the patient's posture and ejection time, wherein the patient's ejection time comprises at least one of the patient's left ventricular ejection time and right ventricular ejection time;
a sensing module coupled to the sensing apparatus and configured to receive the monitored physiological parameters; and
a control module coupled to the sensing module and configured to:
detect a change in the patient's posture between a lying position and an upright position using the monitored physiological parameters,
determine a posture-induced change to the patient's ejection time using the monitored physiological parameters, wherein the posture-induced change to the patient's ejection time comprises a difference between the patient's ejection time before the detected change in the patient's posture and the patient's ejection time after the detected change in the patient's posture,
store the posture-induced change to the patient's ejection time, and
analyze the posture-induced change to the patient's ejection time to provide an assessment of one or more conditions of the patient, wherein the one or more conditions of the patient comprise fluid overload.
2. The device of claim 1 , wherein the posture-induced change to the patient's ejection time further comprises a difference between the patient's average ejection time over a first plurality of heart beats before the detected change in the patient's posture and the patient's average ejection time over a second plurality of heart beats after the detected change in the patient's posture.
3. The device of claim 1 , wherein the posture-induced change to the patient's ejection time further comprises a difference between the patient's average ejection time over a first predetermined period of time before the detected change in the patient's posture and the patient's average ejection time over a second predetermined period of time after the detected change in the patient's posture.
4. The device of claim 1 , wherein the control module is configured to analyze the posture-induced change to the patient's ejection time by comparing the posture-induced change to the patient's ejection time to a baseline value.
5. The device of claim 1 , wherein the control module is configured to analyze the posture-induced change to the patient's ejection time by comparing the posture-induced change to the patient's ejection time to a plurality of previous posture-induced changes to the patient's ejection time prior to the posture-induced change to the patient's ejection time to provide one or more trends to be used in the assessment of one or more conditions of the patient.
6. The device of claim 1 , wherein the analysis of the posture-induced change to the patient's ejection time provides an assessment that indicates that the patient is afflicted with fluid overload if the posture-induced change to the patient's ejection time is less than a 10 percent change.
7. The device of claim 1 further comprising at least one of:
a therapy delivery module coupled to the control module and configured to deliver cardiac therapy to the patient, wherein the control module is further configured to initiate or adjust cardiac therapy using the therapy delivery module based on the assessment of one or more conditions of the patient, and
a notification module coupled to the control module and configured to alert the patient, wherein the control module is configured to initiate an alert using the notification module based on the assessment of one or more conditions of the patient.
8. An implantable medical device for use in assessment of one or more conditions of a patient comprising:
sensing apparatus to monitor physiological parameters of the patient, wherein the physiological parameters comprise the patient's posture and ejection time, wherein the patient's ejection time comprises at least one of the patient's left ventricular ejection time and right ventricular ejection time;
a sensing module coupled to the sensing apparatus and configured to receive the monitored physiological parameters; and
a control module coupled to the sensing module and configured to:
detect changes in the patient's posture between a lying position and an upright position using the monitored physiological parameters,
determine a plurality of posture-induced changes to the patient's ejection time over time using the monitored physiological parameters, wherein each of the plurality of posture-induced changes to the patient's ejection time comprise a difference between the patient's ejection time before a detected change in the patient's posture and the patient's ejection time after the detected change in the patient's posture,
store each of the plurality posture-induced changes to the patient's ejection time, and
analyze the plurality of posture-induced changes to the patient's ejection time over time to provide one or more trends to be used in an assessment of one or more conditions of the patient, wherein the one or more conditions of the patient comprises fluid overload.
9. The device of claim 8 , wherein each of the plurality of posture-induced changes to the patient's ejection time comprise a difference between the patient's average ejection time over a first plurality of heart beats before the detected change in the patient's posture and the patient's average ejection time over a second plurality of heart beats after the detected change in the patient's posture.
10. The device of claim 8 , wherein the control module is configured to analyze the one or more trends in the plurality of posture-induced changes to the patient's ejection time over time by determining whether the posture-induced changes to the patient's ejection time have been decreasing over time, wherein the control module is further configure to provide an assessment that indicates that the patient's heart is progressing towards heart failure if the posture-induced changes to the patient's ejection time have been decreasing over time.
11. The device of claim 8 , wherein the physiological parameters further comprise the patient's heart rate, wherein the control module is further configured to:
determine a posture-induced change to the patient's heart rate using the monitored physiological parameters, wherein the posture-induced change to the patient's heart rate comprises a difference between the patient's heart rate before the detected change in the patient's posture and the patient's heart rate after the detected change in the patient's posture,
store the posture-induced change to the patient's heart rate, and
analyze the posture-induced change to the patient's heart rate to verify the assessment of one or more conditions of the patient.
12. A method for use in assessing one or more conditions of a patient comprising:
monitoring physiological parameters of the patient, wherein the physiological parameters comprise the patient's posture and ejection time, wherein the patient's ejection time comprises at least one of the patient's left ventricular ejection time and right ventricular ejection time;
detecting a change in the patient's posture between a lying position and an upright position using the monitored physiological parameters;
determining a posture-induced change to the patient's ejection time using the monitored physiological parameters, wherein the posture-induced change to the patient's ejection time comprises a difference between the patient's ejection time before the detected change in the patient's posture and the patient's ejection time after the detected change in the patient's posture;
storing the posture-induced change to the patient's ejection time; and
analyzing the posture-induced change to the patient's ejection time to provide an assessment of one or more conditions of the patient, wherein the one or more conditions of the patient comprise fluid overload.
13. The method of claim 12 , wherein the posture-induced change to the patient's ejection time further comprises a difference between the patient's average ejection time over a first plurality of heart beats before the detected change in the patient's posture and the patient's average ejection time over a second plurality of heart beats after the detected change in the patient's posture.
14. The method of claim 12 , wherein the posture-induced change to the patient's ejection time further comprises a difference between the patient's average ejection time over a first predetermined period of time before the detected change in the patient's posture and the patient's average ejection time over a second predetermined period of time after the detected change in the patient's posture.
15. The method of claim 12 , wherein analyzing the posture-induced change to the patient's ejection time comprises comparing the posture-induced change to the patient's ejection time to a baseline value.
16. The method of claim 12 , wherein analyzing the posture-induced change to the patient's ejection time comprises comparing the posture-induced change to the patient's ejection time to a plurality of previous posture-induced changes to the patient's ejection time prior to the posture-induced change to the patient's ejection time to provide one or more trends to be used in the assessment of one or more conditions of the patient.
17. The method of claim 12 further comprising at least one of:
initiating or adjusting cardiac therapy to the patient based on the assessment of one or more conditions of the patient; and
alerting the patient based on the assessment of one or more conditions of the patient.
18. A method for use in assessment of one or more conditions of a patient comprising:
monitoring physiological parameters of the patient, wherein the physiological parameters comprise the patient's posture and ejection time, wherein the patient's ejection time comprises at least one of the patient's left ventricular ejection time and right ventricular ejection time;
detecting changes in the patient's posture between a lying position and an upright position using the monitored physiological parameters,
determining a plurality of posture-induced changes to the patient's ejection time over time using the monitored physiological parameters, wherein each of the plurality of posture-induced changes to the patient's ejection time comprise a difference between the patient's ejection time before a detected change in the patient's posture and the patient's ejection time after the detected change in the patient's posture,
storing each of the plurality posture-induced changes to the patient's ejection time, and
analyzing one or more trends in the plurality of posture-induced changes to the patient's ejection time over time to provide an assessment of one or more conditions of the patient, wherein the one or more conditions of the patient comprises fluid overload.
19. The method of claim 18 , wherein each of the plurality of posture-induced changes to the patient's ejection time comprise a difference between the patient's average ejection time over a first plurality of heart beats before the detected change in the patient's posture and the patient's average ejection time over a second plurality of heart beats after the detected change in the patient's posture.
20. The method of claim 18 , wherein analyzing the one or more trends in the plurality of posture-induced changes to the patient's ejection time over time comprises:
determining whether the posture-induced changes to the patient's ejection time have been decreasing over time, and
providing an assessment that indicates that the patient's heart is progressing towards heart failure if the posture-induced changes to the patient's ejection time have been decreasing over time.
21. The method of claim 18 further comprising:
determining a posture-induced change to the patient's heart rate time using the monitored physiological parameters, wherein the posture-induced change to the patient's heart rate comprises a difference between the patient's heart rate before the detected change in the patient's posture and the patient's heart rate after the detected change in the patient's posture,
storing the posture-induced change to the patient's heart rate, and
analyzing the posture-induced change to the patient's heart rate to verify the assessment of one or more conditions of the patient.
22. The method of claim 18 , wherein analyzing one or more trends in the plurality of posture-induced changes to the patient's ejection time over time comprises analyzing one or more trends in the plurality of posture-induced changes to the patient's ejection time that occur at the same time of the day.
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