US20140291888A1 - Inhalation therapy device with a nozzle nebuliser - Google Patents
Inhalation therapy device with a nozzle nebuliser Download PDFInfo
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- US20140291888A1 US20140291888A1 US14/266,145 US201414266145A US2014291888A1 US 20140291888 A1 US20140291888 A1 US 20140291888A1 US 201414266145 A US201414266145 A US 201414266145A US 2014291888 A1 US2014291888 A1 US 2014291888A1
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- Prior art keywords
- nozzle
- nozzle element
- forming
- aerosol
- outlet
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/0012—Apparatus for achieving spraying before discharge from the apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/24—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas with means, e.g. a container, for supplying liquid or other fluent material to a discharge device
- B05B7/2402—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device
- B05B7/2405—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle
- B05B7/2435—Apparatus to be carried on or by a person, e.g. by hand; Apparatus comprising containers fixed to the discharge device using an atomising fluid as carrying fluid for feeding, e.g. by suction or pressure, a carried liquid from the container to the nozzle the carried liquid and the main stream of atomising fluid being brought together by parallel conduits placed one inside the other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B15/00—Details of spraying plant or spraying apparatus not otherwise provided for; Accessories
- B05B15/50—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter
- B05B15/52—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter for removal of clogging particles
- B05B15/528—Arrangements for cleaning; Arrangements for preventing deposits, drying-out or blockage; Arrangements for detecting improper discharge caused by the presence of foreign matter for removal of clogging particles by resilient deformation of the nozzle
Definitions
- the invention relates to an inhalation therapy device with a nozzle nebuliser, in particular with a nozzle nebuliser having a nozzle element which is easy to clean and is thereby simple and reliable to handle.
- Inhalation therapy devices are used to administer suitable medicaments in the form of an aerosol to patients suffering from disorders of the respiratory tract.
- By adjusting the droplet size owing to a corresponding design of a nebuliser it is possible to control those sites (pharynx, bronchi, lungs) at which the medicament is supposed to be deposited.
- the patient inhales the nebulised medicament through his mouth via a mouthpiece in order to adapt the inhalation therapy device to the patient to an optimum extent.
- the geometry of the nozzle element has an essential role in this regard, the nozzle element being part of the aerosol generator.
- the aerosol generator and the nozzle are normally exposed to contamination caused by residual medicament, sputum (saliva) and exhalation condensate.
- the components of the nebuliser must therefore be cleaned regularly in order to free them of residual medicament, exhalation condensate and sputum residue.
- the components of the nebuliser should be designed so that they can be cleaned thoroughly in a simple manner.
- An inhalation therapy device is normally configured such that it can be cleaned and sterilised in order to remove residual medicament, sputum residue or other such contaminations.
- the inhalation therapy device can normally be opened or dismantled in such a manner that cleaning and/or sterilisation is possible without any problems.
- the nozzle of a nebuliser or an aerosol generator often comprises sharp, precisely manufactured edges, which are necessary to achieve a reproducible droplet spectrum and a good yield, i.e. efficiency of the nebuliser.
- These geometries of the edges are very sensitive, particularly during cleaning of the nozzle, and they can thus only be cleaned with great care and effort. Finally, it is virtually impossible to prevent damage to the geometry of the nozzle in the medium to long term.
- Inhalation therapy devices having nebulisers or aerosol generators are known from the prior art, for example from EP 0 786 263, which can be dismantled such that they can be cleaned, for instance, under running water or sterilised in an autoclave.
- the inhalation therapy device can be opened such that the nozzle of the aerosol generator is freely accessible and can thus be reached by a cleaning fluid.
- a cleaning fluid for example a brush or cloth.
- the object of the present invention is to eliminate the disadvantages of the inhalation therapy devices of the prior art and to provide an inhalation therapy device having an aerosol generator with a nozzle that is easy to clean owing to its construction and is thereby simple and reliable to handle so that the nozzle is not damaged and the geometry of the nozzle is not affected during cleaning.
- an inhalation therapy device having a nebulising chamber and an aerosol generator which is arranged such that it releases an aerosol into the nebulising chamber, said aerosol generator comprising a nozzle element, with the nozzle consisting of at least a first part and a second part, said first part of the nozzle element being made of a more resilient material than the second part of the nozzle element, and the first part of the nozzle element being attached to the second part of the nozzle element.
- the first part of the nozzle element advantageously has a cross-section which tapers further than that of the second part of the nozzle element.
- the first part of the nozzle is advantageously made of silicone rubber or a thermoplastic elastomer (TPE).
- TPE thermoplastic elastomer
- the first part of the nozzle element is advantageously produced together with the second part of the nozzle element in a two-component method, the first part of the nozzle element thereby being moulded on the second part of the nozzle element.
- the first part of the nozzle element advantageously contains the nozzle outlet.
- the nozzle advantageously comprises a third part, which contains the nozzle outlet.
- the third part of the nozzle element advantageously has a cross-section which tapers further than that of the first part of the nozzle element.
- the third part of the nozzle element is preferably produced together with the first part of the nozzle element in a two-component method.
- the third part of the nozzle element is advantageously made of a less resilient material than the first part of the nozzle element.
- the object of the present invention is furthermore solved by means of an inhalation therapy device having a nebulising chamber and an aerosol generator which is arranged such that it releases an aerosol into the nebulising chamber, said aerosol generator comprising a nozzle element, with the nozzle element consisting of at least a first part, said first part of the nozzle element being made of a more resilient material than a member of the inhalation therapy device on which the nozzle element is moulded or to which the nozzle element is attached.
- FIG. 1 shows an inhalation therapy device with an aerosol generator having a nozzle according to a first embodiment of the present invention
- FIG. 2 shows a nozzle element according to the first embodiment of the present invention
- FIG. 3 shows a nozzle element according to a second embodiment of the present invention
- FIG. 4 shows a nozzle element according to a third embodiment of the present invention.
- FIG. 5 shows a nozzle element according to a fourth embodiment of the present invention.
- FIG. 1 shows an inhalation therapy device 1 according to a first embodiment of the present invention.
- the inhalation therapy device comprises a nebulising chamber 2 , attached to which is, for example, a mouthpiece 21 via which the patient can inhale the nebulised medicament in the form of an aerosol 4 .
- the inhalation therapy device can furthermore be provided with inhalation and exhalation valves (not shown here) such that a flow of respiratory air can be guided so as to achieve the optimum supply of an aerosol 4 to the patient.
- An aerosol generator 3 is provided in the nebulising chamber 2 , which is able to generate an aerosol 4 .
- the aerosol generator 3 comprises a nozzle element 5 , through which compressed air is guided in the present embodiment.
- the aerosol generator 3 furthermore comprises one or more channels 32 , via which a medicament can be guided out of a storage container 6 and into the vicinity of the nozzle outlet 55 through which the compressed air guided by the nozzle element 5 escapes.
- the channels can, for example, be formed by means of a suitable member 31 , which is designed such that one or more channels 32 are formed between the nozzle element 5 or the nozzle parts 51 , 52 and the member 31 .
- the medicament is sucked through the channels 32 and entrained by the compressed air which flows out of the nozzle outlet 55 , such that a mixture of compressed air and medicament passes through the opening 35 of the member 31 and is released into the nebulising chamber 2 .
- an impact baffle 38 is disposed in front of the opening 35 of the aerosol generator 3 , said impact baffle having the object of controlling the air flow with the medicament such that when the medicament droplets collide with the impact baffle 38 , an aerosol 4 , 42 having a desired droplet spectrum is obtained.
- the aerosol 4 , 42 is entrained therewith and inhaled by the patient via the mouthpiece 21 .
- the nozzle body 5 of the aerosol generator 3 consists of a first part 51 and a second part 52 , with the first part 51 of the nozzle element 5 having a cross-section which tapers further than that of the second part 52 of the nozzle element 5 .
- the cross-section of the nozzle body is tapered further by the first part 51 of the nozzle element so that the cross-section decreases in the direction of the nozzle tip.
- the first part 51 of the nozzle element 5 comprises the nozzle rim or nozzle edge having the nozzle outlet 55 .
- the first part 51 of the nozzle element 5 is made of a more resilient material than the second part 52 of the nozzle element 5 in this embodiment.
- resilience is to be understood as a material property which causes an element made from the material to resume its original shape of its own accord following deformation.
- This may, for example, be a silicone rubber or an elastomer that has this property, namely advantageously even in the case of a scratching stress, without incurring morphological damage, and resumes its original shape.
- a material is described as more resilient if, as compared to a less resilient material, it resumes its original form to a greater extent, virtually without any remaining deformation.
- the member 31 can generally be removed so that the channels 32 for supplying the medicament are exposed, which improves the possibility for cleaning. Furthermore, the removal of the member 31 exposes the nozzle body such that it can be cleaned by a rinsing or cleaning liquid. Owing to the fact that the first part 51 of the nozzle element 5 is configured so as to be more resilient than the second part 52 of the nozzle element 5 , the upper, first part 51 of the nozzle element 5 can deform in a resilient manner during cleaning.
- the resilient deformation of part 52 of the nozzle element 5 is a virtually completely reversible deformation, the first part 51 of the nozzle element 5 resumes the original shape following cleaning such that the original geometry of the nozzle is maintained, without damage occurring to the nozzle geometry.
- the first part 51 of the nozzle element 5 is attached to or moulded on the second part 52 of the nozzle element 5 .
- the at least two nozzle parts 51 , 52 are fixedly connected to one another, as can be seen in the embodiment shown in FIG. 1 , in order to prevent them from becoming detached from one another and to ensure a low friction or friction-free and low turbulence or turbulence-free transition.
- the so-called two-component method two-component injection moulding method
- two or more suitable, albeit different materials, from which parts of an assembly are made to be produced in injection moulding as a single part in an assembly.
- the parts of the assembly are then fixedly connected together and the transitions between one another can be connected almost without steps or indentations and essentially also without gaps. This ensures a low friction or friction-free and low turbulence or turbulence-free transition in the present case.
- the second part 52 of the nozzle element 5 is made of a less resilient material than the first part 51 of the nozzle element 5 , such that the deformability of the first part ensures a yielding during mechanical cleaning of the nozzle element 5 , which essentially lowers the risk of damaging the nozzle element.
- the resilient material can thereby be a silicone rubber or a thermoplastic elastomer (TPE).
- TPE thermoplastic elastomer
- the latter can be readily processed with less resilient materials, such as polyethylene (PE) or polypropylene (PP), in the two-component injection moulding method, such that the TPE parts and the PE or PP parts are fixedly connected together.
- FIG. 2 shows an embodiment of the present invention in which the nozzle element 5 consists of a first part 51 and a second part 52 .
- the first part 51 contains the nozzle outlet 55 .
- the nozzle outlet 55 or the nozzle edge is reversibly deformable such that in the case of cleaning and a resulting deformation, part 51 of the nozzle element 5 can resume its original shape again as soon as the mechanical effect of cleaning no longer exists.
- the part 51 of the nozzle element 5 can be designed such that by selecting a corresponding resilient material, the nozzle outlet 55 is widened in dependence on the flow of compressed air through said nozzle outlet 55 , such that a stable state between the air flowing through and the medicament sucked through the channels 32 can be established in the aerosol generator 3 .
- This embodiment is particularly advantageous if particles, which may possibly block the outlet 55 , are already added to the compressed air during supply, so that the nozzle outlet is widened by the accumulated compressed air such that blocking of the nozzle outlet can be prevented.
- a further advantage of a part 51 designed in a resilient manner, which contains the nozzle outlet 55 is the simplified possibility of removing solid contaminating particles tightly adhering to or in the nozzle tip, which become detached when the resilient material is deformed. An improved cleaning is thus ensured. Owing to a resilient deformation of the nozzle outlet 55 , solid particles blocking the nozzle outlet 55 can thus also be removed, without the geometry of the nozzle suffering lasting damage.
- FIG. 3 shows an embodiment in which the nozzle body 5 comprises a third part 53 .
- the third part 53 is again less resilient than the first part 51 of the nozzle element 5 .
- the third part 53 of the nozzle element 5 contains the nozzle outlet 55 .
- the advantage of such an embodiment is that the nozzle outlet 55 , or the rim surrounding the nozzle outlet, can be produced from a more dimensionally stable material, however owing to the more resilient part 51 , can yield under pressure or as a result of other mechanical influences such that damage cannot occur to the upper part, in this case the third part 53 , of the nozzle element 5 .
- the resilient part 51 of the nozzle element 5 deforms in the shown embodiment and, once the mechanical influence no longer exists, resumes the original shape again such that the dimensional stability of the nozzle is retained.
- the boundary between the first part 51 of the nozzle element 5 and the second part of the nozzle element does not necessarily have to be in the top part of the nozzle element 5 , as is shown in FIG. 4 .
- the connecting region between the first part 51 of the nozzle element 5 and the second part 52 of the nozzle element 5 can rather also be in the bottom region of the nozzle element, which is attached, for example, to a housing part 11 , without departing from the application area of the invention.
- the nozzle element can also be completely produced from a more resilient material than a component 11 of the inhalation therapy device on which the nozzle element 5 is formed or to which the nozzle element is attached.
- the nozzle element can, for example, be configured as a plug-in type element which is inserted into a provided opening 15 during production. Production is thereby simplified and the nozzle element 5 can possibly be exchanged in the case of damage.
- the nozzle element 5 can take on sealing functions, for example in case of an attached tube supply 18 .
- the nozzle element 5 can thereby advantageously be made of a resilient material such as, for example, silicone rubber or a thermoplastic elastomer (TPE).
- TPE thermoplastic elastomer
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Abstract
The invention relates to an inhalation therapy device with a nozzle nebuliser, in particular with a nozzle nebuliser having a nozzle element which is easy to clean and is thereby simple and reliable to handle so that the nozzle is not damaged and the geometry of the nozzle is not affected during cleaning. The aerosol generator comprises a nozzle element, said nozzle consisting of at least a first part and a second part, said first part of the nozzle element being made of a more resilient material than said second part of the nozzle element, and said first part of the nozzle element being attached to said second part of the nozzle element. Owing to the resilient material, the nozzle can deform during cleaning and can return to the original shape without altering its initial geometry.
Description
- This application is a continuation of U.S. application Ser. No. 10/575,933, filed 15 Nov. 2006, which is a national stage application of PCT/EP2004/010140, filed 10 Sep. 2004, which claims benefit of Ser. No. 103 48 237.7, filed 16 Oct. 2003 in Germany, and which applications are incorporated herein by reference. To the extent appropriate, a claim of priority is made to each of the above disclosed applications.
- The invention relates to an inhalation therapy device with a nozzle nebuliser, in particular with a nozzle nebuliser having a nozzle element which is easy to clean and is thereby simple and reliable to handle.
- Inhalation therapy devices are used to administer suitable medicaments in the form of an aerosol to patients suffering from disorders of the respiratory tract. By adjusting the droplet size owing to a corresponding design of a nebuliser, it is possible to control those sites (pharynx, bronchi, lungs) at which the medicament is supposed to be deposited. The patient inhales the nebulised medicament through his mouth via a mouthpiece in order to adapt the inhalation therapy device to the patient to an optimum extent.
- In order to generate the aerosol with a desired droplet spectrum, it is necessary to precisely realise the geometry of the nebuliser or aerosol generator in order to avoid deviations and modifications over the lifespan of the inhalation therapy device. The geometry of the nozzle element has an essential role in this regard, the nozzle element being part of the aerosol generator. By manufacturing the nozzle element in a precise manner, it is thus ensured that the aerosol has a reproducible droplet spectrum.
- In an inhalation therapy device, the aerosol generator and the nozzle are normally exposed to contamination caused by residual medicament, sputum (saliva) and exhalation condensate. To comply with hygiene requirements, especially if the inhalation therapy device is being used by several patients, the components of the nebuliser must therefore be cleaned regularly in order to free them of residual medicament, exhalation condensate and sputum residue. For this purpose, the components of the nebuliser should be designed so that they can be cleaned thoroughly in a simple manner. An inhalation therapy device is normally configured such that it can be cleaned and sterilised in order to remove residual medicament, sputum residue or other such contaminations. For this purpose, the inhalation therapy device can normally be opened or dismantled in such a manner that cleaning and/or sterilisation is possible without any problems.
- The nozzle of a nebuliser or an aerosol generator often comprises sharp, precisely manufactured edges, which are necessary to achieve a reproducible droplet spectrum and a good yield, i.e. efficiency of the nebuliser. These geometries of the edges are very sensitive, particularly during cleaning of the nozzle, and they can thus only be cleaned with great care and effort. Finally, it is virtually impossible to prevent damage to the geometry of the nozzle in the medium to long term.
- Cleaning of the nebuliser components or the nozzle must, however, be made possible for the reasons already cited above. It must be possible for a patient who is generally unaware of the problem of the sensitive geometry of the nozzle to nevertheless carry out this cleaning without any problems, in particular patients suffering from physical impairments as a consequence of their respiratory disease.
- Inhalation therapy devices having nebulisers or aerosol generators are known from the prior art, for example from EP 0 786 263, which can be dismantled such that they can be cleaned, for instance, under running water or sterilised in an autoclave. For this purpose, the inhalation therapy device can be opened such that the nozzle of the aerosol generator is freely accessible and can thus be reached by a cleaning fluid. However, in the case of tightly adhering particles, rinsing with a cleaning fluid is generally not sufficient and therefore mechanical cleaning of the nozzle possibly has to be carried out. This inevitably leads to the use of a cleaning tool, for example a brush or cloth. This considerably increases the risk of damaging the sensitive geometry of the edges of the nozzle and of consequently modifying the desired droplet spectrum of the aerosol generator of the inhalation therapy device. The inhalation therapy device having a nebuliser or an aerosol generator would become ineffective in many cases since the droplet spectrum is essential for the type of therapy.
- The object of the present invention is to eliminate the disadvantages of the inhalation therapy devices of the prior art and to provide an inhalation therapy device having an aerosol generator with a nozzle that is easy to clean owing to its construction and is thereby simple and reliable to handle so that the nozzle is not damaged and the geometry of the nozzle is not affected during cleaning.
- This object is solved by means of an inhalation therapy device having a nebulising chamber and an aerosol generator which is arranged such that it releases an aerosol into the nebulising chamber, said aerosol generator comprising a nozzle element, with the nozzle consisting of at least a first part and a second part, said first part of the nozzle element being made of a more resilient material than the second part of the nozzle element, and the first part of the nozzle element being attached to the second part of the nozzle element.
- The first part of the nozzle element advantageously has a cross-section which tapers further than that of the second part of the nozzle element.
- The first part of the nozzle is advantageously made of silicone rubber or a thermoplastic elastomer (TPE). The first part of the nozzle element is advantageously produced together with the second part of the nozzle element in a two-component method, the first part of the nozzle element thereby being moulded on the second part of the nozzle element.
- The first part of the nozzle element advantageously contains the nozzle outlet.
- According to a further embodiment, the nozzle advantageously comprises a third part, which contains the nozzle outlet.
- The third part of the nozzle element advantageously has a cross-section which tapers further than that of the first part of the nozzle element.
- The third part of the nozzle element is preferably produced together with the first part of the nozzle element in a two-component method.
- The third part of the nozzle element is advantageously made of a less resilient material than the first part of the nozzle element.
- The object of the present invention is furthermore solved by means of an inhalation therapy device having a nebulising chamber and an aerosol generator which is arranged such that it releases an aerosol into the nebulising chamber, said aerosol generator comprising a nozzle element, with the nozzle element consisting of at least a first part, said first part of the nozzle element being made of a more resilient material than a member of the inhalation therapy device on which the nozzle element is moulded or to which the nozzle element is attached.
- The invention will be described in more detail below by means of embodiments and with reference to the drawings. In the drawings:
-
FIG. 1 shows an inhalation therapy device with an aerosol generator having a nozzle according to a first embodiment of the present invention; -
FIG. 2 shows a nozzle element according to the first embodiment of the present invention; -
FIG. 3 shows a nozzle element according to a second embodiment of the present invention; -
FIG. 4 shows a nozzle element according to a third embodiment of the present invention; and -
FIG. 5 shows a nozzle element according to a fourth embodiment of the present invention. -
FIG. 1 shows an inhalation therapy device 1 according to a first embodiment of the present invention. The inhalation therapy device comprises anebulising chamber 2, attached to which is, for example, amouthpiece 21 via which the patient can inhale the nebulised medicament in the form of an aerosol 4. - The inhalation therapy device can furthermore be provided with inhalation and exhalation valves (not shown here) such that a flow of respiratory air can be guided so as to achieve the optimum supply of an aerosol 4 to the patient. An
aerosol generator 3 is provided in thenebulising chamber 2, which is able to generate an aerosol 4. - The
aerosol generator 3 comprises anozzle element 5, through which compressed air is guided in the present embodiment. Theaerosol generator 3 furthermore comprises one ormore channels 32, via which a medicament can be guided out of astorage container 6 and into the vicinity of thenozzle outlet 55 through which the compressed air guided by thenozzle element 5 escapes. The channels can, for example, be formed by means of asuitable member 31, which is designed such that one ormore channels 32 are formed between thenozzle element 5 or thenozzle parts member 31. Owing to an injection or venturi effect, the medicament is sucked through thechannels 32 and entrained by the compressed air which flows out of thenozzle outlet 55, such that a mixture of compressed air and medicament passes through the opening 35 of themember 31 and is released into thenebulising chamber 2. - In this embodiment, an
impact baffle 38 is disposed in front of theopening 35 of theaerosol generator 3, said impact baffle having the object of controlling the air flow with the medicament such that when the medicament droplets collide with theimpact baffle 38, anaerosol 4, 42 having a desired droplet spectrum is obtained. The droplets of themedicament 4, 41 exiting theaerosol generator 3 collide with thebaffle 38, thereby resulting in a splitting of the aerosol droplets and making it possible to providesmaller aerosol droplets 4, 42. As a result of a corresponding air flow, which is generated by means of respiratory air supplied from the outside through a possibly present inhalation valve, theaerosol 4, 42 is entrained therewith and inhaled by the patient via themouthpiece 21. - In the embodiment shown here, the
nozzle body 5 of theaerosol generator 3 consists of afirst part 51 and asecond part 52, with thefirst part 51 of thenozzle element 5 having a cross-section which tapers further than that of thesecond part 52 of thenozzle element 5. The cross-section of the nozzle body is tapered further by thefirst part 51 of the nozzle element so that the cross-section decreases in the direction of the nozzle tip. In the embodiment shown here, thefirst part 51 of thenozzle element 5 comprises the nozzle rim or nozzle edge having thenozzle outlet 55. Thefirst part 51 of thenozzle element 5 is made of a more resilient material than thesecond part 52 of thenozzle element 5 in this embodiment. - Within the meaning of the invention, resilience is to be understood as a material property which causes an element made from the material to resume its original shape of its own accord following deformation. This may, for example, be a silicone rubber or an elastomer that has this property, namely advantageously even in the case of a scratching stress, without incurring morphological damage, and resumes its original shape. A material is described as more resilient if, as compared to a less resilient material, it resumes its original form to a greater extent, virtually without any remaining deformation.
- For cleaning of the
aerosol generator 3, themember 31 can generally be removed so that thechannels 32 for supplying the medicament are exposed, which improves the possibility for cleaning. Furthermore, the removal of themember 31 exposes the nozzle body such that it can be cleaned by a rinsing or cleaning liquid. Owing to the fact that thefirst part 51 of thenozzle element 5 is configured so as to be more resilient than thesecond part 52 of thenozzle element 5, the upper,first part 51 of thenozzle element 5 can deform in a resilient manner during cleaning. - Since the resilient deformation of
part 52 of thenozzle element 5 is a virtually completely reversible deformation, thefirst part 51 of thenozzle element 5 resumes the original shape following cleaning such that the original geometry of the nozzle is maintained, without damage occurring to the nozzle geometry. Thefirst part 51 of thenozzle element 5 is attached to or moulded on thesecond part 52 of thenozzle element 5. - The at least two
nozzle parts FIG. 1 , in order to prevent them from becoming detached from one another and to ensure a low friction or friction-free and low turbulence or turbulence-free transition. - In terms of production, the so-called two-component method (two-component injection moulding method), for example, is available for this purpose, with which it is possible for two or more suitable, albeit different materials, from which parts of an assembly are made, to be produced in injection moulding as a single part in an assembly. The parts of the assembly are then fixedly connected together and the transitions between one another can be connected almost without steps or indentations and essentially also without gaps. This ensures a low friction or friction-free and low turbulence or turbulence-free transition in the present case.
- The
second part 52 of thenozzle element 5 is made of a less resilient material than thefirst part 51 of thenozzle element 5, such that the deformability of the first part ensures a yielding during mechanical cleaning of thenozzle element 5, which essentially lowers the risk of damaging the nozzle element. The resilient material can thereby be a silicone rubber or a thermoplastic elastomer (TPE). The latter can be readily processed with less resilient materials, such as polyethylene (PE) or polypropylene (PP), in the two-component injection moulding method, such that the TPE parts and the PE or PP parts are fixedly connected together. -
FIG. 2 shows an embodiment of the present invention in which thenozzle element 5 consists of afirst part 51 and asecond part 52. In this embodiment, thefirst part 51 contains thenozzle outlet 55. On account of the moreresilient part 51 of thenozzle element 5 as compared to the lessresilient part 52 of thenozzle element 5, thenozzle outlet 55 or the nozzle edge is reversibly deformable such that in the case of cleaning and a resulting deformation,part 51 of thenozzle element 5 can resume its original shape again as soon as the mechanical effect of cleaning no longer exists. - In a further advantageous embodiment, the
part 51 of thenozzle element 5 can be designed such that by selecting a corresponding resilient material, thenozzle outlet 55 is widened in dependence on the flow of compressed air through saidnozzle outlet 55, such that a stable state between the air flowing through and the medicament sucked through thechannels 32 can be established in theaerosol generator 3. This embodiment is particularly advantageous if particles, which may possibly block theoutlet 55, are already added to the compressed air during supply, so that the nozzle outlet is widened by the accumulated compressed air such that blocking of the nozzle outlet can be prevented. A further advantage of apart 51 designed in a resilient manner, which contains thenozzle outlet 55, is the simplified possibility of removing solid contaminating particles tightly adhering to or in the nozzle tip, which become detached when the resilient material is deformed. An improved cleaning is thus ensured. Owing to a resilient deformation of thenozzle outlet 55, solid particles blocking thenozzle outlet 55 can thus also be removed, without the geometry of the nozzle suffering lasting damage. -
FIG. 3 shows an embodiment in which thenozzle body 5 comprises athird part 53. Thethird part 53 is again less resilient than thefirst part 51 of thenozzle element 5. In this embodiment, thethird part 53 of thenozzle element 5 contains thenozzle outlet 55. The advantage of such an embodiment is that thenozzle outlet 55, or the rim surrounding the nozzle outlet, can be produced from a more dimensionally stable material, however owing to the moreresilient part 51, can yield under pressure or as a result of other mechanical influences such that damage cannot occur to the upper part, in this case thethird part 53, of thenozzle element 5. When cleaning the nozzle, theresilient part 51 of thenozzle element 5 deforms in the shown embodiment and, once the mechanical influence no longer exists, resumes the original shape again such that the dimensional stability of the nozzle is retained. - The demands on handlability, the mechanical effects to be endured and the stresses to be expected determine the selection of the material for the
respective parts - In the present invention, the boundary between the
first part 51 of thenozzle element 5 and the second part of the nozzle element does not necessarily have to be in the top part of thenozzle element 5, as is shown inFIG. 4 . The connecting region between thefirst part 51 of thenozzle element 5 and thesecond part 52 of thenozzle element 5 can rather also be in the bottom region of the nozzle element, which is attached, for example, to ahousing part 11, without departing from the application area of the invention. - According to a further embodiment, the nozzle element can also be completely produced from a more resilient material than a
component 11 of the inhalation therapy device on which thenozzle element 5 is formed or to which the nozzle element is attached. As shown inFIG. 5 , the nozzle element can, for example, be configured as a plug-in type element which is inserted into a providedopening 15 during production. Production is thereby simplified and thenozzle element 5 can possibly be exchanged in the case of damage. Furthermore, thenozzle element 5 can take on sealing functions, for example in case of an attachedtube supply 18. - The
nozzle element 5 can thereby advantageously be made of a resilient material such as, for example, silicone rubber or a thermoplastic elastomer (TPE). The dimensional stability when in use is ensured by themember 31. When themember 31 is removed, thenozzle element 5 is exposed and, owing to its resilience, is not greatly exposed to a risk of damage during cleaning.
Claims (13)
1. A method for making an inhalation therapy device, the method comprising:
forming a nebulizing chamber;
forming an aerosol generator arranged to release an aerosol into the nebulizing chamber with a medicament, the aerosol generator comprising a nozzle and an outer member;
forming the nozzle from a first part and a second part, said first part of the nozzle comprising a resilient deformable material, and including a deformable tip having a nozzle outlet with a nozzle edge configured to deliver a reproducible droplet spectrum of said aerosol through the nozzle outlet;
forming the second part of the nozzle;
molding the first part of the nozzle on the second part of the nozzle; the first part of the nozzle tapering from the second part with a cross-section of the first part converging to the deformable nozzle tip; and
placing a removable outer member in the nebulizing chamber to define at least one medicament channel extending between the nozzle and an outer member and in fluid communication with the nozzle outlet.
2. The method according to claim 1 , comprising forming the first part of the nozzle of a reversible deformable material, wherein the nozzle outlet widens in dependence on flow through the nozzle outlet so that a stable state is established between flow and medicament sucked into the flow.
3. The method according to claim 1 , wherein the first part of the nozzle is produced with the second part of the nozzle in a two-component method, comprising molding the first part of the nozzle on the second part of the nozzle.
4. The method according to claim 3 , comprising making said first part of the nozzle from a more resilient material than the second part.
5. The method according to claim 1 , comprising making said first part of the nozzle from a more resilient material than the second part.
6. The method according to claim 1 , comprising molding the first part and the second part from two different materials.
7. The method according to claim 1 , wherein the forming of the nozzle comprises injection molding the first part and attaching to the second part to form a nozzle assembly.
8. The method according to claim 7 , comprising fixedly connecting the first and second parts so that the transitions between the first part and the second part are free of steps, indentations or gaps.
9. The method according to claim 1 , wherein the first part of the nozzle is silicone rubber or a thermoplastic elastomer (TPE).
10. The method according to claim 1 , wherein the second part of the nozzle comprises polyethylene or polypropylene.
11. The method according to claim 1 , comprising making the first part of the nozzle with a cross-section which tapers further than a cross-section of the second part of said nozzle.
12. The method according to claim 1 , wherein the first part of the nozzle consists of a resilient material resuming original geometry following deformation.
13. The method according to claim 1 , comprising molding the nozzle edge so as to be reversibly deformable.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/266,145 US20140291888A1 (en) | 2003-10-16 | 2014-04-30 | Inhalation therapy device with a nozzle nebuliser |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10348237.7 | 2003-10-16 | ||
DE10348237A DE10348237A1 (en) | 2003-10-16 | 2003-10-16 | Inhalation therapy device with a jet nebulizer |
PCT/EP2004/010140 WO2005042075A1 (en) | 2003-10-16 | 2004-09-10 | Inhalation therapy device with a nozzle atomizer |
US57593306A | 2006-11-15 | 2006-11-15 | |
US14/266,145 US20140291888A1 (en) | 2003-10-16 | 2014-04-30 | Inhalation therapy device with a nozzle nebuliser |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
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US10/575,933 Continuation US8739777B2 (en) | 2003-10-16 | 2004-09-10 | Inhalation therapy device with a nozzle nebuliser |
PCT/EP2004/010140 Continuation WO2005042075A1 (en) | 2003-10-16 | 2004-09-10 | Inhalation therapy device with a nozzle atomizer |
Publications (1)
Publication Number | Publication Date |
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US20140291888A1 true US20140291888A1 (en) | 2014-10-02 |
Family
ID=34442023
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US10/575,933 Active 2027-04-21 US8739777B2 (en) | 2003-10-16 | 2004-09-10 | Inhalation therapy device with a nozzle nebuliser |
US14/266,145 Abandoned US20140291888A1 (en) | 2003-10-16 | 2014-04-30 | Inhalation therapy device with a nozzle nebuliser |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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US10/575,933 Active 2027-04-21 US8739777B2 (en) | 2003-10-16 | 2004-09-10 | Inhalation therapy device with a nozzle nebuliser |
Country Status (5)
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US (2) | US8739777B2 (en) |
EP (1) | EP1673124B1 (en) |
JP (1) | JP4580933B2 (en) |
DE (2) | DE10348237A1 (en) |
WO (1) | WO2005042075A1 (en) |
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MX2022012360A (en) | 2020-04-01 | 2022-10-21 | Union Therapeutics As | Treatment. |
US11045434B1 (en) | 2020-04-01 | 2021-06-29 | UNION therapeutics A/S | Niclosamide formulations for treating disease |
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Also Published As
Publication number | Publication date |
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JP4580933B2 (en) | 2010-11-17 |
EP1673124B1 (en) | 2008-02-13 |
DE10348237A1 (en) | 2005-05-19 |
WO2005042075A1 (en) | 2005-05-12 |
US8739777B2 (en) | 2014-06-03 |
JP2007508078A (en) | 2007-04-05 |
EP1673124A1 (en) | 2006-06-28 |
DE502004006208D1 (en) | 2008-03-27 |
US20070068513A1 (en) | 2007-03-29 |
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