US20140034847A1 - Photoluminescent oxygen probe tack - Google Patents
Photoluminescent oxygen probe tack Download PDFInfo
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- US20140034847A1 US20140034847A1 US13/567,362 US201213567362A US2014034847A1 US 20140034847 A1 US20140034847 A1 US 20140034847A1 US 201213567362 A US201213567362 A US 201213567362A US 2014034847 A1 US2014034847 A1 US 2014034847A1
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- oxygen
- probe
- head
- sensitive
- underside
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N21/643—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
- G01N21/85—Investigating moving fluids or granular solids
- G01N21/8507—Probe photometers, i.e. with optical measuring part dipped into fluid sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/207497—Molecular oxygen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/207497—Molecular oxygen
- Y10T436/209163—Dissolved or trace oxygen or oxygen content of a sealed environment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25875—Gaseous sample or with change of physical state
Definitions
- Solid-state polymeric materials based on oxygen-sensitive photoluminescent dyes are widely used as optical oxygen probes. See, for example United States Published Patent Applications 2009/0029402, 2008/8242870, 2008/215254, 2008/199360, 2008/190172, 2008/148817, 2008/146460, 2008/117418, 2008/0051646, 2006/0002822 and U.S. Pat. Nos. 7,569,395, 7,534,615, 7,368,153, 7,138,270, 6,689,438, 5,718,842, 4,810,655, and 4,476,870.
- Such optical probes are available from a number of suppliers, including Presens Precision Sensing, GmbH of Regensburg, Germany, Oxysense of Dallas, Tex., United States, and Luxcel Biosciences, Ltd of Cork, Ireland.
- Such probes may be interrogated through many common packaging materials and therefore allow nondestructive measurement of the oxygen concentration within an enclosure by simply incorporating a probe within the packaging, typically adhered to the inside surface of the cover.
- a probe within the packaging
- Such a probe into the packaging is not acceptable—such as packages made from materials that interfere with interrogation of the probe (e.g., opaque and metalized films), packages in which the presence of such a probe inside the packaging may be mistakenly perceived by consumers as an undesired contamination of the packaged product, or packages whose per package value or profit margin cannot accommodate the cost of incorporating a probe into every package or tracking those containing a probe when only select packages include a probe.
- a first aspect of the invention is a photoluminescent oxygen probe comprising (a) a tack with a head and a shank extending longitudinally from an underside of the head, (b) a layer of a pressure-sensitive adhesive on the underside of the head, and (c) an oxygen-sensitive photoluminescent element on the underside of the head.
- the oxygen-sensitive photoluminescent element is preferably comprised of a photoluminescent dye embedded within an oxygen-permeable hydrophobic polymer carrier.
- a second aspect of the invention is a method for measuring oxygen concentration within a space enclosed by a structure employing an oxygen-sensitive probe according to the first aspect of the invention.
- the method includes the steps of (A) obtaining a photoluminescent oxygen probe according to the first aspect of the invention, (B) puncturing the structure with the probe's shank, (C) adhering the underside of the probe's head to an exterior surface of the container so as to sealingly surround the puncture, thereby placing the oxygen-sensitive photoluminescent dye on the underside of the probe's head into sensible communication with the enclosed space through the puncture, (D) allowing the oxygen concentration in sensible communication with the layer of oxygen-sensitive photoluminescent dye to equilibrate with the oxygen concentration within the enclosed space, and (E) ascertaining an oxygen concentration within the enclosed space by: (i) exposing the oxygen-sensitive photoluminescent dye on the underside of the probe's head to excitation radiation through the probe's head, (ii) measuring radiation emitted by the excited oxygen-sensitive
- a third aspect of the invention is a method for monitoring changes in oxygen concentration within an enclosed space employing an oxygen-sensitive probe according to the first aspect of the invention.
- the method includes the steps of (A) obtaining a photoluminescent oxygen probe according to the first aspect of the invention, (B) puncturing the structure with the probe's shank, (C) adhering the underside of the probe's head to an exterior surface of the container so as to sealingly surround the puncture, thereby placing the oxygen-sensitive photoluminescent dye on the underside of the probe's head into sensible communication with the enclosed space through the puncture, (D) allowing the oxygen concentration in sensible communication with the layer of oxygen-sensitive photoluminescent dye to equilibrate with the oxygen concentration within the enclosed space, (E) ascertaining an oxygen concentration within the enclosed space over time by: (i) repeatedly exposing the equilibrated oxygen-sensitive photoluminescent dye on the underside of the probe's head to excitation radiation through the probe's head over time, (ii) measuring radiation emitted
- FIG. 1 is an exploded perspective view of one embodiment of the invention.
- FIG. 2 is a top view of the invention depicted in FIG. 1 .
- FIG. 3 is a side view of the invention depicted in FIG. 1 .
- FIG. 4 is a partial cross-sectional side view of the invention depicted in FIG. 1 taken along line 4 - 4 with the thickness of each layer grossly enlarged to facilitate viewing of the individual layers.
- FIG. 5 is a microscopically enlarged view of a portion of the oxygen-sensitive photoluminescent element depicted in FIG. 4 to facilitate viewing of the individual discrete strands of the element.
- FIG. 6 is a further microscopically enlarged cross-sectional view of one of the strands of the oxygen-sensitive photoluminescent element depicted in FIG. 5 to facilitate viewing of the individual discrete components of the element.
- FIG. 7 is a side view of the invention depicted in FIG. 1 applied to a package.
- FIG. 8 is a cross-sectional side view of a central portion of the invention depicted in FIG. 6 with the thickness of each layer grossly enlarged to facilitate viewing of the individual layers.
- the term “foodstuff” means any substance suitable for being eaten or drunk by animals, including humans, for nutrition or pleasure, or used as an ingredient in such a substance.
- oxygen impermeable means a material that has an oxygen transmission rate of less than 0.1 cm 3 /m 2 day when measured in accordance with ASTM D 3985.
- the invention is an oxygen-sensitive probe or sensor 10 useful for optically measuring oxygen concentration within an enclosed space S, such as the retention chamber S of a hermetically sealed package P containing a foodstuff F.
- the probe 10 includes a tack 20 , oxygen-sensitive photoluminescent element 30 and layer of a pressure-sensitive adhesive 40 .
- the tack 20 has a head 21 and a shank 22 .
- the head 21 should be transparent or translucent to radiation at the excitation and emission wavelengths of the photoluminescent element 30 . Suitable materials include specifically, but not exclusively, glass and various polymers such as poly(methyl methacrylate) and clear vinyl.
- the shank 22 extends longitudinally from the underside 21 b of the head 21 .
- the distal end 22 b of the shank 22 forms a sharp suitable for piercing typical packaging materials such as mylar films, polyethylene and polypropylene containers, polyvinyl chloride bottles, etc.
- the head 21 preferably has a diameter of about 6 to 20 mm, most preferably about 10 to 15 mm
- the shank 22 preferably has a longitudinal length of about 6 to 20 mm, most preferably about 10 to 15 mm.
- a head 21 with a diameter smaller than about 6 mm is difficult to manufacture and awkward to use, while a diameter greater than about 20 mm increases the expense of the tack 20 without a concomitant improvement in handling or performance.
- a shank 22 with a length smaller than about 6 mm hinders the ability of the tack 20 to effectively penetrate and pierce through packages or containers P, while a length greater than about 20 mm increases the expense of the tack 20 without a concomitant improvement in handling or performance.
- both the oxygen-sensitive photoluminescent element 30 and the layer of pressure-sensitive adhesive 40 are positioned on the underside 21 b of the head 21 of the tack 20 .
- the oxygen-sensitive photoluminescent element 30 includes an oxygen-sensitive photoluminescent dye 33 , preferably embedded within an oxygen-permeable polymer carrier 32 , and coated onto a support structure 31 .
- the oxygen-sensitive photoluminescent dye 33 may be selected from any of the well-known oxygen sensitive photoluminescent dyes 33 .
- One of routine skill in the art is capable of selecting a suitable dye 33 based upon the intended use of the probe 10 .
- a nonexhaustive list of suitable oxygen sensitive photoluminescent dyes 33 includes specifically, but not exclusively, ruthenium(II)-bipyridyl and ruthenium(II)-diphenylphenanothroline complexes, porphyrin-ketones such as platinum(II)-octaethylporphine-ketone, platinum(II)-porphyrin such as platinum(II)-tetrakis(pentafluorophenyl)porphine, palladium(II)-porphyrin such as palladium(II)-tetrakis(pentafluorophenyl)porphine, phosphorescent metallocomplexes of
- the oxygen-sensitive photoluminescent dye 33 is compounded with a suitable oxygen-permeable and hydrophobic polymeric carrier 32 .
- a suitable oxygen-permeable and hydrophobic polymeric carrier 32 is capable of selecting a suitable carrier 32 based upon the intended use of the probe 10 and the selected dye 33 .
- suitable polymers for use as the oxygen-permeable hydrophobic carrier 32 includes specifically, but not exclusively, polystryrene, polycarbonate, polysulfone, polyvinyl chloride and some co-polymers.
- the support structure 31 should be constructed from a material capable of providing sufficient structural integrity to the oxygen-sensitive photoluminescent element 30 .
- the material should also be transparent or translucent to radiation at the excitation and emission wavelengths of the dye 33 in the photoluminescent element 30 .
- Suitable materials include specifically, but not exclusively, glass, spunbond glass fibers and polymeric films such as PET, Nylon, PVDC (Saran), etc.
- the probe 10 includes a layer of a pressure sensitive adhesive 40 on underside 21 b of the head 21 of the tack 20 —the same side as the photoluminescent element 30 —for adhering the probe 10 to the surface (unnumbered) of a container or package P defining an enclosed space or retention chamber S whose oxygen concentration is to be measured.
- the adhesive 40 may but preferably does not cover the photoluminescent element 30 .
- the probe 10 can be placed into sensing communication with the retention chamber S of a container or package P by pushing the shank 22 of the tack 20 through the lid or sidewall of the container or package P and pressing the adhesive layer 40 on the underside 21 b of the head 21 of the tack 20 into sealing engagement with the container or package P. Once the probe 10 is adhered to the container or package P, oxygen is exchanged between the photoluminescent element 30 and the content of the retention chamber S of the container or package P through the opening (unnumbered) in the container or package P created by the shank 22 of the tack 20 .
- the thickness of the pressure-sensitive adhesive layer 40 should be limited (e.g., about 1 to 2 mm) so as to minimize the surface area exposed to the surrounding environment, and a sizable margin 50 provided from the edge(s) 49 of the adhesive layer 40 to the edge(s) 39 of the photoluminescent element 30 (e.g., about 1 to 10 mm) to maximize the width of the adhesive between the surrounding environment and the photoluminescent element 30 .
- the desired effect can generally be achieved with a peripheral margin 50 of between about 1 to 10 mm, most preferably about 2 to 5 mm.
- a peripheral margin 50 less than about 1 mm does not provide a sufficient delay nor reduction in radial oxygen diffusion through the adhesive layer 40 and into sensing contact with the photoluminescent element 30 , while a peripheral margin 50 of greater than about 10 mm increases the expense of the tack 20 without a concomitant improvement in performance.
- a release liner 60 is preferably employed over the exposed surface of the adhesive layer 40 to prevent contamination and premature adhesion of probe 10 during storage and handling.
- a radially extending tab 61 can be provided on the release liner 60 to facilitate removal.
- a label 70 can be adhered to the topside 21 a of the head 21 of the tack 20 for provided relevant information about the probe 10 such as source, type, phone number for ordering additional probes 10 or obtaining technical support, website address where purchasing and performance details can be obtained, etc.
- relevant information about the probe 10 such as source, type, phone number for ordering additional probes 10 or obtaining technical support, website address where purchasing and performance details can be obtained, etc.
- the label 70 needs to be transparent or translucent to radiation at the excitation and emission wavelengths of the photoluminescent element 30 , or (2) that portion of the label 70 which would overlay the photoluminescent element 30 needs to be removed (e.g., an annular label).
- the probe 10 can be conveniently manufactured by (1) obtaining a suitable tack 20 , (2) spindling a photoluminescent element 30 (with or without a prepunched hole) onto the underside 21 b of the head 21 of the tack 20 , (3) applying a layer of pressure-sensitive adhesive 40 onto the underside 21 b of the head 21 of the tack 20 before or after the photoluminescent element 30 is spindled onto the tack 20 using conventional coating techniques, (4) spindling a release liner 60 (with or without a prepunched hole) over the exposed surface (unnumbered) of the adhesive layer 40 , and (5) optionally applying a label 70 to the topside 21 a of the head 21 of the tack 20 .
- the photoluminescent element 30 can be manufactured by the traditional methods employed for manufacturing such elements 30 .
- the element 30 can be conveniently manufactured by (A) preparing a coating cocktail (not shown) which contains the photoluminescent oxygen-sensitive dye 33 and an oxygen-permeable carrier polymer 32 in an organic solvent (not shown) such as ethylacetate, (B) applying the cocktail to the support structure 31 , and (C) allowing the cocktail (not shown) to dry, whereby a solid-state thin film oxygen-sensitive photoluminescent element 30 is formed on the support structure 31 .
- a coating cocktail not shown
- an oxygen-permeable carrier polymer 32 such as ethylacetate
- the concentration of the carrier polymer 32 in the organic solvent should be in the range of 0.1 to 20% w/w, with the ratio of dye 33 to polymer 32 in the range of 1:20 to 1:10,000 w/w, preferably 1:50 to 1:5,000 w/w.
- the probe 10 can be used to quickly, easily, accurately and reliably measure oxygen concentration within an enclosed space S.
- the probe 10 is used to measure oxygen concentration within an enclosed space S by (A) pushing the shank 22 of the tack 20 through the lid or sidewall of a container or package P defining the enclosed space S until the adhesive layer 40 on the underside 21 b of the head 21 of the tack 20 sealingly engages the container or package P, thereby placing the photoluminescent element 30 in sensible communication with the enclosed space S through the opening (unnumbered) in the container or package P created by the shank 22 of the tack 20 , (B) allowing the concentration of oxygen in sensible communication with the oxygen-sensitive photoluminescent element 30 to equilibrate with the oxygen concentration in the enclosed space S, and (C) ascertaining oxygen concentration within the enclosed space S by (i) exposing the oxygen-sensitive photoluminescent element 30 to excitation radiation through the head 21 of the tack 20 , (ii) measuring radiation emitted by the excited oxygen-sensitive photolumin
- the probe 10 can be used to quickly, easily, accurately and reliably monitor changes in oxygen concentration within an enclosed space S.
- the probe 10 is used to monitor changes in oxygen concentration within an enclosed space S by (A) pushing the shank 22 of the tack 20 through the lid or sidewall of a container or package P defining the enclosed space S until the adhesive layer 40 on the underside 21 b of the head 21 of the tack 20 sealingly engages the container or package P, thereby placing the photoluminescent element 30 in sensible communication with the enclosed space S through the opening (unnumbered) in the container or package P created by the shank 22 of the tack 20 , (B) allowing the concentration of oxygen in sensible communication with the oxygen-sensitive photoluminescent element 30 to equilibrate with the oxygen concentration in the enclosed space S, (C) ascertaining oxygen concentration within the enclosed space S by (i) repeatedly exposing the oxygen-sensitive photoluminescent element 30 to excitation radiation through the head 21 of the tack 20 over time, (ii) measuring radiation
- the radiation emitted by the excited probe 10 can be measured in terms of intensity and/or lifetime (rate of decay, phase shift or anisotropy), with measurement of lifetime generally preferred as a more accurate and reliable measurement technique when seeking to establish oxygen concentration via measurement of the extent to which the dye 33 in the photoluminescent element 30 has been quenched by oxygen.
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Abstract
Description
- Solid-state polymeric materials based on oxygen-sensitive photoluminescent dyes are widely used as optical oxygen probes. See, for example United States Published Patent Applications 2009/0029402, 2008/8242870, 2008/215254, 2008/199360, 2008/190172, 2008/148817, 2008/146460, 2008/117418, 2008/0051646, 2006/0002822 and U.S. Pat. Nos. 7,569,395, 7,534,615, 7,368,153, 7,138,270, 6,689,438, 5,718,842, 4,810,655, and 4,476,870. Such optical probes are available from a number of suppliers, including Presens Precision Sensing, GmbH of Regensburg, Germany, Oxysense of Dallas, Tex., United States, and Luxcel Biosciences, Ltd of Cork, Ireland.
- Such probes may be interrogated through many common packaging materials and therefore allow nondestructive measurement of the oxygen concentration within an enclosure by simply incorporating a probe within the packaging, typically adhered to the inside surface of the cover. Unfortunately, there are certain applications where incorporation of such a probe into the packaging is not acceptable—such as packages made from materials that interfere with interrogation of the probe (e.g., opaque and metalized films), packages in which the presence of such a probe inside the packaging may be mistakenly perceived by consumers as an undesired contamination of the packaged product, or packages whose per package value or profit margin cannot accommodate the cost of incorporating a probe into every package or tracking those containing a probe when only select packages include a probe.
- Hence, a need exists for an inexpensive disposable probe that can be systematically employed in accordance with a quality control program to quickly and accurately inspect the oxygen concentration within indiscriminately selected packages.
- A first aspect of the invention is a photoluminescent oxygen probe comprising (a) a tack with a head and a shank extending longitudinally from an underside of the head, (b) a layer of a pressure-sensitive adhesive on the underside of the head, and (c) an oxygen-sensitive photoluminescent element on the underside of the head. The oxygen-sensitive photoluminescent element is preferably comprised of a photoluminescent dye embedded within an oxygen-permeable hydrophobic polymer carrier.
- A second aspect of the invention is a method for measuring oxygen concentration within a space enclosed by a structure employing an oxygen-sensitive probe according to the first aspect of the invention. The method includes the steps of (A) obtaining a photoluminescent oxygen probe according to the first aspect of the invention, (B) puncturing the structure with the probe's shank, (C) adhering the underside of the probe's head to an exterior surface of the container so as to sealingly surround the puncture, thereby placing the oxygen-sensitive photoluminescent dye on the underside of the probe's head into sensible communication with the enclosed space through the puncture, (D) allowing the oxygen concentration in sensible communication with the layer of oxygen-sensitive photoluminescent dye to equilibrate with the oxygen concentration within the enclosed space, and (E) ascertaining an oxygen concentration within the enclosed space by: (i) exposing the oxygen-sensitive photoluminescent dye on the underside of the probe's head to excitation radiation through the probe's head, (ii) measuring radiation emitted by the excited oxygen-sensitive photoluminescent dye, and (iii) converting the measured emission to an oxygen concentration based upon a known conversion algorithm.
- A third aspect of the invention is a method for monitoring changes in oxygen concentration within an enclosed space employing an oxygen-sensitive probe according to the first aspect of the invention. The method includes the steps of (A) obtaining a photoluminescent oxygen probe according to the first aspect of the invention, (B) puncturing the structure with the probe's shank, (C) adhering the underside of the probe's head to an exterior surface of the container so as to sealingly surround the puncture, thereby placing the oxygen-sensitive photoluminescent dye on the underside of the probe's head into sensible communication with the enclosed space through the puncture, (D) allowing the oxygen concentration in sensible communication with the layer of oxygen-sensitive photoluminescent dye to equilibrate with the oxygen concentration within the enclosed space, (E) ascertaining an oxygen concentration within the enclosed space over time by: (i) repeatedly exposing the equilibrated oxygen-sensitive photoluminescent dye on the underside of the probe's head to excitation radiation through the probe's head over time, (ii) measuring radiation emitted by the excited equilibrated oxygen-sensitive photoluminescent dye after at least some of the exposures, (iii) measuring passage of time during the repeated excitation exposures and emission measurements, and (iv) converting at least some of the measured emissions to an oxygen concentration based upon a known conversion algorithm, and (F) reporting at least one of (i) at least two ascertained oxygen concentrations and the time interval between those reported concentrations, and (ii) a rate of change in oxygen concentration within the enclosed space calculated from data obtained in step (E).
-
FIG. 1 is an exploded perspective view of one embodiment of the invention. -
FIG. 2 is a top view of the invention depicted inFIG. 1 . -
FIG. 3 is a side view of the invention depicted inFIG. 1 . -
FIG. 4 is a partial cross-sectional side view of the invention depicted inFIG. 1 taken along line 4-4 with the thickness of each layer grossly enlarged to facilitate viewing of the individual layers. -
FIG. 5 is a microscopically enlarged view of a portion of the oxygen-sensitive photoluminescent element depicted inFIG. 4 to facilitate viewing of the individual discrete strands of the element. -
FIG. 6 is a further microscopically enlarged cross-sectional view of one of the strands of the oxygen-sensitive photoluminescent element depicted inFIG. 5 to facilitate viewing of the individual discrete components of the element. -
FIG. 7 is a side view of the invention depicted inFIG. 1 applied to a package. -
FIG. 8 is a cross-sectional side view of a central portion of the invention depicted inFIG. 6 with the thickness of each layer grossly enlarged to facilitate viewing of the individual layers. - As used herein, including the claims, the term “foodstuff” means any substance suitable for being eaten or drunk by animals, including humans, for nutrition or pleasure, or used as an ingredient in such a substance.
- As used herein, including the claims, the phrase “oxygen impermeable” means a material that has an oxygen transmission rate of less than 0.1 cm3/m2 day when measured in accordance with ASTM D 3985.
- 10 Oxygen Probe
- 20 Tack
- 21 Head of Tack
- 21 a Topside of Head
- 21 b Underside of Head
- 22 Shank of Tack
- 22 b Distal End of Shank
- 30 Oxygen-Sensitive Photoluminescent Element
- 31 Support Structure
- 32 Polymer Carrier
- 33 Oxygen-Sensitive Photoluminescent Dye
- 34 Coated Individual Strand of Support Structure
- 39 Peripheral Edge of Oxygen-Sensitive Photoluminescent Element
- 40 Pressure Sensitive Adhesive Layer
- 49 Peripheral Edge of Pressure Sensitive Adhesive Layer
- 50 Peripheral Margin
- 60 Release Liner
- 61 Tab on Release Liner
- 70 Label
- F Foodstuff
- P Hermetically Sealed Packaging
- S Retention Chamber or Space
- Construction and Theory of Operation
- Referring generally to
FIG. 7 , the invention is an oxygen-sensitive probe orsensor 10 useful for optically measuring oxygen concentration within an enclosed space S, such as the retention chamber S of a hermetically sealed package P containing a foodstuff F. Referring generally toFIGS. 1 , 2 and 3, theprobe 10 includes atack 20, oxygen-sensitivephotoluminescent element 30 and layer of a pressure-sensitive adhesive 40. - The
tack 20 has ahead 21 and ashank 22. Thehead 21 should be transparent or translucent to radiation at the excitation and emission wavelengths of thephotoluminescent element 30. Suitable materials include specifically, but not exclusively, glass and various polymers such as poly(methyl methacrylate) and clear vinyl. Theshank 22 extends longitudinally from theunderside 21 b of thehead 21. Thedistal end 22 b of theshank 22 forms a sharp suitable for piercing typical packaging materials such as mylar films, polyethylene and polypropylene containers, polyvinyl chloride bottles, etc. - For typical applications, the
head 21 preferably has a diameter of about 6 to 20 mm, most preferably about 10 to 15 mm, and theshank 22 preferably has a longitudinal length of about 6 to 20 mm, most preferably about 10 to 15 mm. Ahead 21 with a diameter smaller than about 6 mm is difficult to manufacture and awkward to use, while a diameter greater than about 20 mm increases the expense of thetack 20 without a concomitant improvement in handling or performance. Ashank 22 with a length smaller than about 6 mm hinders the ability of thetack 20 to effectively penetrate and pierce through packages or containers P, while a length greater than about 20 mm increases the expense of thetack 20 without a concomitant improvement in handling or performance. - Referring to
FIG. 4 , both the oxygen-sensitivephotoluminescent element 30 and the layer of pressure-sensitive adhesive 40 are positioned on theunderside 21 b of thehead 21 of thetack 20. - Referring to
FIGS. 5 and 6 , the oxygen-sensitivephotoluminescent element 30 includes an oxygen-sensitivephotoluminescent dye 33, preferably embedded within an oxygen-permeable polymer carrier 32, and coated onto asupport structure 31. - The oxygen-sensitive
photoluminescent dye 33 may be selected from any of the well-known oxygen sensitivephotoluminescent dyes 33. One of routine skill in the art is capable of selecting asuitable dye 33 based upon the intended use of theprobe 10. A nonexhaustive list of suitable oxygensensitive photoluminescent dyes 33 includes specifically, but not exclusively, ruthenium(II)-bipyridyl and ruthenium(II)-diphenylphenanothroline complexes, porphyrin-ketones such as platinum(II)-octaethylporphine-ketone, platinum(II)-porphyrin such as platinum(II)-tetrakis(pentafluorophenyl)porphine, palladium(II)-porphyrin such as palladium(II)-tetrakis(pentafluorophenyl)porphine, phosphorescent metallocomplexes of tetrabenzoporphyrins, chlorins, azaporphyrins, and long-decay luminescent complexes of iridium(III) or osmium(II). - Typically and preferably, the oxygen-
sensitive photoluminescent dye 33 is compounded with a suitable oxygen-permeable andhydrophobic polymeric carrier 32. Again, one of routine skill in the art is capable of selecting asuitable carrier 32 based upon the intended use of theprobe 10 and the selecteddye 33. A nonexhaustive list of suitable polymers for use as the oxygen-permeablehydrophobic carrier 32 includes specifically, but not exclusively, polystryrene, polycarbonate, polysulfone, polyvinyl chloride and some co-polymers. - The
support structure 31 should be constructed from a material capable of providing sufficient structural integrity to the oxygen-sensitive photoluminescent element 30. The material should also be transparent or translucent to radiation at the excitation and emission wavelengths of thedye 33 in thephotoluminescent element 30. Suitable materials include specifically, but not exclusively, glass, spunbond glass fibers and polymeric films such as PET, Nylon, PVDC (Saran), etc. - Referring generally to
FIGS. 1 and 4 , theprobe 10 includes a layer of a pressuresensitive adhesive 40 onunderside 21 b of thehead 21 of thetack 20—the same side as thephotoluminescent element 30—for adhering theprobe 10 to the surface (unnumbered) of a container or package P defining an enclosed space or retention chamber S whose oxygen concentration is to be measured. The adhesive 40 may but preferably does not cover thephotoluminescent element 30. - Referring to
FIGS. 7 and 8 , theprobe 10 can be placed into sensing communication with the retention chamber S of a container or package P by pushing theshank 22 of thetack 20 through the lid or sidewall of the container or package P and pressing theadhesive layer 40 on theunderside 21 b of thehead 21 of thetack 20 into sealing engagement with the container or package P. Once theprobe 10 is adhered to the container or package P, oxygen is exchanged between thephotoluminescent element 30 and the content of the retention chamber S of the container or package P through the opening (unnumbered) in the container or package P created by theshank 22 of thetack 20. Unless theprobe 10 is read for several days after being applied to a container or package P, diffusion of oxygen across thehead 21 of thetack 20 is statistically insignificant. In those situations where diffusion of oxygen across thehead 21 of thetack 20 may become an issue, diffusion can be minimized by constructing thetack 20 from an oxygen impermeable material (i.e., an extremely low oxygen transmission rate (OTR)) or applying a coating of an oxygen impermeable material to thehead 21 of thetack 20. Unfortunately, this same option is not available for minimizing diffusion across the layer of pressure-sensitive adhesive 40 as pressure-sensitive adhesives have a fairly high OTR. Hence, in order to minimize diffusion from the sides of theprobe 10, the thickness of the pressure-sensitive adhesive layer 40 should be limited (e.g., about 1 to 2 mm) so as to minimize the surface area exposed to the surrounding environment, and asizable margin 50 provided from the edge(s) 49 of theadhesive layer 40 to the edge(s) 39 of the photoluminescent element 30 (e.g., about 1 to 10 mm) to maximize the width of the adhesive between the surrounding environment and thephotoluminescent element 30. The desired effect can generally be achieved with aperipheral margin 50 of between about 1 to 10 mm, most preferably about 2 to 5 mm. Aperipheral margin 50 less than about 1 mm does not provide a sufficient delay nor reduction in radial oxygen diffusion through theadhesive layer 40 and into sensing contact with thephotoluminescent element 30, while aperipheral margin 50 of greater than about 10 mm increases the expense of thetack 20 without a concomitant improvement in performance. - A
release liner 60 is preferably employed over the exposed surface of theadhesive layer 40 to prevent contamination and premature adhesion ofprobe 10 during storage and handling. Aradially extending tab 61 can be provided on therelease liner 60 to facilitate removal. - A
label 70 can be adhered to the topside 21 a of thehead 21 of thetack 20 for provided relevant information about theprobe 10 such as source, type, phone number for orderingadditional probes 10 or obtaining technical support, website address where purchasing and performance details can be obtained, etc. When employed, either (1) Thelabel 70 needs to be transparent or translucent to radiation at the excitation and emission wavelengths of thephotoluminescent element 30, or (2) that portion of thelabel 70 which would overlay thephotoluminescent element 30 needs to be removed (e.g., an annular label). - Manufacture
- The
probe 10 can be conveniently manufactured by (1) obtaining asuitable tack 20, (2) spindling a photoluminescent element 30 (with or without a prepunched hole) onto theunderside 21 b of thehead 21 of thetack 20, (3) applying a layer of pressure-sensitive adhesive 40 onto theunderside 21 b of thehead 21 of thetack 20 before or after thephotoluminescent element 30 is spindled onto thetack 20 using conventional coating techniques, (4) spindling a release liner 60 (with or without a prepunched hole) over the exposed surface (unnumbered) of theadhesive layer 40, and (5) optionally applying alabel 70 to the topside 21 a of thehead 21 of thetack 20. - The
photoluminescent element 30 can be manufactured by the traditional methods employed for manufacturingsuch elements 30. Briefly, theelement 30 can be conveniently manufactured by (A) preparing a coating cocktail (not shown) which contains the photoluminescent oxygen-sensitive dye 33 and an oxygen-permeable carrier polymer 32 in an organic solvent (not shown) such as ethylacetate, (B) applying the cocktail to thesupport structure 31, and (C) allowing the cocktail (not shown) to dry, whereby a solid-state thin film oxygen-sensitive photoluminescent element 30 is formed on thesupport structure 31. - Generally, the concentration of the
carrier polymer 32 in the organic solvent (not shown) should be in the range of 0.1 to 20% w/w, with the ratio ofdye 33 topolymer 32 in the range of 1:20 to 1:10,000 w/w, preferably 1:50 to 1:5,000 w/w. - Use
- The
probe 10 can be used to quickly, easily, accurately and reliably measure oxygen concentration within an enclosed space S. Briefly, theprobe 10 is used to measure oxygen concentration within an enclosed space S by (A) pushing theshank 22 of thetack 20 through the lid or sidewall of a container or package P defining the enclosed space S until theadhesive layer 40 on theunderside 21 b of thehead 21 of thetack 20 sealingly engages the container or package P, thereby placing thephotoluminescent element 30 in sensible communication with the enclosed space S through the opening (unnumbered) in the container or package P created by theshank 22 of thetack 20, (B) allowing the concentration of oxygen in sensible communication with the oxygen-sensitive photoluminescent element 30 to equilibrate with the oxygen concentration in the enclosed space S, and (C) ascertaining oxygen concentration within the enclosed space S by (i) exposing the oxygen-sensitive photoluminescent element 30 to excitation radiation through thehead 21 of thetack 20, (ii) measuring radiation emitted by the excited oxygen-sensitive photoluminescent element 30 through thehead 21 of thetack 20, and (iii) converting the measured emission to an oxygen concentration based upon a known conversion algorithm. Such conversion algorithms are well know to and readily developable by those with routine skill in the art. - In a similar fashion, the probe 10 can be used to quickly, easily, accurately and reliably monitor changes in oxygen concentration within an enclosed space S. Briefly, the probe 10 is used to monitor changes in oxygen concentration within an enclosed space S by (A) pushing the shank 22 of the tack 20 through the lid or sidewall of a container or package P defining the enclosed space S until the adhesive layer 40 on the underside 21 b of the head 21 of the tack 20 sealingly engages the container or package P, thereby placing the photoluminescent element 30 in sensible communication with the enclosed space S through the opening (unnumbered) in the container or package P created by the shank 22 of the tack 20, (B) allowing the concentration of oxygen in sensible communication with the oxygen-sensitive photoluminescent element 30 to equilibrate with the oxygen concentration in the enclosed space S, (C) ascertaining oxygen concentration within the enclosed space S by (i) repeatedly exposing the oxygen-sensitive photoluminescent element 30 to excitation radiation through the head 21 of the tack 20 over time, (ii) measuring radiation emitted by the excited oxygen-sensitive photoluminescent element 30 through the head 21 of the tack 20 after at least some of the exposures, (iii) measuring passage of time during the repeated excitation exposures and emission measurements, and (iv) converting at least some of the measured emission to an oxygen concentration based upon a known conversion algorithm, and (D) reporting at least one of (i) at least two ascertained oxygen concentrations and the time interval between those reported concentrations, or (ii) a rate of change in oxygen concentration within the enclosed space S calculated from data obtained in step (C). Again, conversion algorithms used to convert the measured emissions to an oxygen concentration are well know to and readily developable by those with routine skill in the art.
- The radiation emitted by the
excited probe 10 can be measured in terms of intensity and/or lifetime (rate of decay, phase shift or anisotropy), with measurement of lifetime generally preferred as a more accurate and reliable measurement technique when seeking to establish oxygen concentration via measurement of the extent to which thedye 33 in thephotoluminescent element 30 has been quenched by oxygen.
Claims (15)
Priority Applications (3)
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US13/567,362 US8658429B1 (en) | 2012-08-06 | 2012-08-06 | Photoluminescent oxygen probe tack |
EP13174127.4A EP2696194A1 (en) | 2012-08-06 | 2013-06-27 | Photoluminescent oxygen probe tack |
JP2013145232A JP5897508B2 (en) | 2012-08-06 | 2013-07-11 | Photoluminescence oxygen probe tack |
Applications Claiming Priority (1)
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US13/567,362 US8658429B1 (en) | 2012-08-06 | 2012-08-06 | Photoluminescent oxygen probe tack |
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US20140034847A1 true US20140034847A1 (en) | 2014-02-06 |
US8658429B1 US8658429B1 (en) | 2014-02-25 |
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US13/567,362 Active 2032-09-06 US8658429B1 (en) | 2012-08-06 | 2012-08-06 | Photoluminescent oxygen probe tack |
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US (1) | US8658429B1 (en) |
EP (1) | EP2696194A1 (en) |
JP (1) | JP5897508B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20200093439A1 (en) * | 2017-04-28 | 2020-03-26 | Nitto Denko Corporation | Sheet for biosensor |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7085773B2 (en) * | 2001-01-05 | 2006-08-01 | Symyx Technologies, Inc. | Laboratory database system and methods for combinatorial materials research |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3138937A (en) | 1961-03-10 | 1964-06-30 | Virtis Company Inc | Method of producing a gas-tight seal between a pair of adjacent sections of a freeze-drying container |
US4476870A (en) | 1982-03-30 | 1984-10-16 | The United States Of America As Represented By The Department Of Health And Human Services | Fiber optic PO.sbsb.2 probe |
US4784811A (en) | 1982-09-30 | 1988-11-15 | The Regents Of The University Of California | Method of constructing improved pressure-sensitive optrode |
US4810655A (en) | 1985-07-03 | 1989-03-07 | Abbott Laboratories | Method for measuring oxygen concentration |
US5190729A (en) | 1986-09-08 | 1993-03-02 | C. R. Bard, Inc. | Luminescent oxygen sensor based on a lanthanide complex |
US4947850A (en) | 1988-03-11 | 1990-08-14 | Trustees Of The University Of Pennsylvania | Method and apparatus for imaging an internal body portion of a host animal |
US5407829A (en) | 1990-03-27 | 1995-04-18 | Avl Medical Instruments Ag | Method for quality control of packaged organic substances and packaging material for use with this method |
WO1992019150A1 (en) | 1991-05-03 | 1992-11-12 | Innerspace, Inc. | Direct insertable tissue probe |
US6362175B1 (en) | 1991-09-20 | 2002-03-26 | The Trustees Of The University Of Pennsylvania | Porphyrin compounds for imaging tissue oxygen |
US5333609A (en) | 1992-05-19 | 1994-08-02 | Minnesota Mining And Manufacturing Company | Catheter and probe-catheter assembly |
US5382163A (en) | 1992-07-20 | 1995-01-17 | Putnam; David L. | Method and apparatus for detecting the presence of dental plaque or calculus |
US5328823A (en) | 1992-11-27 | 1994-07-12 | American Air Liquide | Enzyme-based biosensors for detecting noble gases |
US5837865A (en) | 1993-10-15 | 1998-11-17 | Trustees Of The University Of Pennsylvania | Phosphorescent dendritic macromolecular compounds for imaging tissue oxygen |
JPH07238181A (en) | 1994-01-21 | 1995-09-12 | Minnesota Mining & Mfg Co <3M> | Hydrophilic porous article |
US5718842A (en) | 1994-10-07 | 1998-02-17 | Joanneum Reserach Forschungsgesellschaft Mbh | Luminescent dye comprising metallocomplex of a oxoporphyrin |
US5863460A (en) | 1996-04-01 | 1999-01-26 | Chiron Diagnostics Corporation | Oxygen sensing membranes and methods of making same |
AU5079698A (en) * | 1996-10-08 | 1998-05-05 | Photonics Biosystems | Microbiological assessment method and device utilizing oxygen gradient sensing |
JP3686188B2 (en) * | 1996-10-30 | 2005-08-24 | 株式会社オートマチック・システムリサーチ | Oxygen concentration measuring sensor and manufacturing method thereof |
US6328932B1 (en) | 1997-05-08 | 2001-12-11 | Eltron Research, Inc. | Devices and methods for the detection of basic gases |
US6165741A (en) | 1997-05-30 | 2000-12-26 | The Trustees Of The University Of Pennsylvania | Method for rapid detection of bacterial growth in cultures |
US6266211B1 (en) | 1997-09-26 | 2001-07-24 | Iomega Corporation | Latent illuminance discrimination marker for data storage cartridges |
US6153701A (en) | 1998-11-20 | 2000-11-28 | International Paper Company | Wettable polypropylene composition and related method of manufacture |
US6410255B1 (en) | 1999-05-05 | 2002-06-25 | Aurora Biosciences Corporation | Optical probes and assays |
US6395555B1 (en) | 1999-10-14 | 2002-05-28 | David F. Wilson | Method and apparatus for determining the effect of a drug on cells |
AT409451B (en) | 1999-12-14 | 2002-08-26 | Hoffmann La Roche | DEVICE FOR DETERMINING THE LOCAL DISTRIBUTION OF A MEASURED VALUE |
US6379969B1 (en) | 2000-03-02 | 2002-04-30 | Agilent Technologies, Inc. | Optical sensor for sensing multiple analytes |
US6689438B2 (en) | 2001-06-06 | 2004-02-10 | Cryovac, Inc. | Oxygen detection system for a solid article |
ATE500894T1 (en) | 2002-01-17 | 2011-03-15 | Univ College Cork Nat Univ Ie | TEST DEVICE AND METHOD FOR CHEMICAL OR BIOLOGICAL SCREENING |
JP2004075155A (en) * | 2002-08-21 | 2004-03-11 | Toppan Printing Co Ltd | Container or packaging body |
US7368153B2 (en) | 2002-12-06 | 2008-05-06 | Cryovac, Inc. | Oxygen detection system for a rigid container |
JP2006522329A (en) | 2003-03-07 | 2006-09-28 | ラクセル・バイオサイエンシズ・リミテッド | Oxygen sensitive probe |
US7384988B2 (en) | 2003-08-26 | 2008-06-10 | Union College | Method and device for fabricating aerogels and aerogel monoliths obtained thereby |
US7787923B2 (en) * | 2003-11-26 | 2010-08-31 | Becton, Dickinson And Company | Fiber optic device for sensing analytes and method of making same |
US7534615B2 (en) | 2004-12-03 | 2009-05-19 | Cryovac, Inc. | Process for detecting leaks in sealed packages |
US20060201830A1 (en) * | 2005-03-09 | 2006-09-14 | Flexplay Technologies, Inc. | Packaging system with oxygen sensor for limited life optical media |
GB0505036D0 (en) | 2005-03-11 | 2005-04-20 | Oxford Optronix Ltd | An optical measurement sensor |
EP1869433A1 (en) | 2005-04-15 | 2007-12-26 | Luxcel Biosciences Limited | Assessment of biological or chemical samples |
JP4358785B2 (en) * | 2005-05-27 | 2009-11-04 | 麒麟麦酒株式会社 | Method for measuring oxygen content in sealed container and piercing device for sealed container used therefor |
CA2609430A1 (en) | 2005-06-02 | 2006-12-07 | Glaxo Group Limited | Inductively powered remote oxygen sensor |
EP1742038A1 (en) | 2005-07-06 | 2007-01-10 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Device and method for determining the concentration of a substance |
EP1742039A1 (en) | 2005-07-07 | 2007-01-10 | F. Hoffmann-La Roche Ltd. | Method for the determination of the concentration of a non-volatile analyte |
US7310142B2 (en) | 2005-08-22 | 2007-12-18 | Sandia National Laboratories | Fast time-correlated multi-element photon detector and method |
JP2009510083A (en) | 2005-09-28 | 2009-03-12 | イノテック ファーマシューティカルズ コーポレイション | N-benzyl-substituted pyridylporphyrin compound and method of using the same |
US7569395B2 (en) | 2006-03-13 | 2009-08-04 | Cryovac, Inc. | Method and apparatus for measuring oxygen concentration |
US7749768B2 (en) | 2006-03-13 | 2010-07-06 | Cryovac, Inc. | Non-invasive method of determining oxygen concentration in a sealed package |
US20070243618A1 (en) | 2006-04-11 | 2007-10-18 | Oxysense, Inc. | Device and method for non-invasive oxygen sensing of sealed packages |
WO2008012785A2 (en) | 2006-07-24 | 2008-01-31 | University College Cork - National University Of Ireland, Cork | A probe for cellular oxygen |
US7679745B2 (en) | 2006-11-21 | 2010-03-16 | Neptec Optical Solutions | Time-resolved fluorescence spectrometer for multiple-species analysis |
US8242162B2 (en) | 2006-12-15 | 2012-08-14 | Ohio Aerospace Institute | Fluorescent aromatic sensors and their methods of use |
US7849729B2 (en) | 2006-12-22 | 2010-12-14 | The Boeing Company | Leak detection in vacuum bags |
US20080199360A1 (en) | 2007-02-16 | 2008-08-21 | Ocean Optics, Inc. | Method and composition for a platinum embedded sol gel optical chemical sensor with improved sensitivity and chemical stability |
US7862770B2 (en) | 2007-07-27 | 2011-01-04 | Ocean Optics, Inc. | Patches for non-intrusive monitoring of oxygen in packages |
WO2010053888A1 (en) * | 2008-11-07 | 2010-05-14 | Mocon, Inc | Calibration card for oxygen optical sensors |
US20100209693A1 (en) | 2009-02-18 | 2010-08-19 | 3M Innovative Properties Company | Hydrophilic porous substrates |
US20110136247A1 (en) * | 2009-12-07 | 2011-06-09 | Dmitri Boris Papkovsky | Photoluminescent oxygen probe with reduced cross-sensitivity to humidity |
US20120129268A1 (en) * | 2010-11-19 | 2012-05-24 | Mayer Daniel W | Photoluminescent oxygen probe with reduced cross-sensitivity to humidity |
-
2012
- 2012-08-06 US US13/567,362 patent/US8658429B1/en active Active
-
2013
- 2013-06-27 EP EP13174127.4A patent/EP2696194A1/en not_active Withdrawn
- 2013-07-11 JP JP2013145232A patent/JP5897508B2/en active Active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20200093439A1 (en) * | 2017-04-28 | 2020-03-26 | Nitto Denko Corporation | Sheet for biosensor |
US11717220B2 (en) * | 2017-04-28 | 2023-08-08 | Nitto Denko Corporation | Sheet for biosensor |
Also Published As
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JP2014032185A (en) | 2014-02-20 |
US8658429B1 (en) | 2014-02-25 |
JP5897508B2 (en) | 2016-03-30 |
EP2696194A1 (en) | 2014-02-12 |
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